{"hash":"1222934015367588608","title":"ER Protein Processing and Unfolded Protein Response","description":"The cluster\u2019s prominent GO terms center on secretory pathway protein maturation and ER stress responses, including ER-to-cytosol proteolysis (ERAD), ER and unfolded protein response, EGFR ligand maturation, and MHC-II antigen processing, with additional developmental fate specification terms that can be tied to signaling via secretory routes. This suggests a shared theme around proteins\u2019 processing and quality control in the secretory/ER pathway, plus related signaling. ","confidence":"Medium","size":22,"edges":17,"triangles":1,"max_degree":4,"top_function":null,"members":[{"accession":"XP_001348741.1","go_terms":[]},{"accession":"XP_001349695.2","go_terms":["GO:0030968"]},{"accession":"XP_002585413.1","go_terms":[]},{"accession":"XP_002585437.1","go_terms":[]},{"accession":"XP_001348248.1","go_terms":["GO:0009627","GO:0030163","GO:0045493","GO:0006508","GO:0002803","GO:0007586","GO:0019886","GO:0002018","GO:0016540","GO:0001823","GO:0002003","GO:0033619","GO:0070305","GO:0042985","GO:0042756","GO:0002016","GO:0050435"]},{"accession":"XP_001348925.1","go_terms":[]},{"accession":"XP_001350052.1","go_terms":[]},{"accession":"XP_001350458.1","go_terms":[]},{"accession":"XP_001352043.1","go_terms":[]},{"accession":"XP_001351311.1","go_terms":[]},{"accession":"XP_002808784.1","go_terms":[]},{"accession":"XP_001347820.2","go_terms":["GO:1904211","GO:0032815","GO:0038005","GO:0042676","GO:0048515","GO:0035311","GO:0034620"]},{"accession":"XP_001348505.1","go_terms":["GO:0006784"]},{"accession":"XP_002808884.1","go_terms":["GO:1904211","GO:0032815","GO:0038005","GO:0042676","GO:0048515","GO:0035311","GO:0034620"]},{"accession":"XP_001348845.2","go_terms":["GO:0035774","GO:1902361","GO:0061732"]},{"accession":"XP_001350313.1","go_terms":["GO:0032469","GO:0034975"]},{"accession":"XP_002808970.1","go_terms":[]},{"accession":"XP_024329126.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_966171.2","go_terms":["GO:0006890","GO:1904211","GO:0032815","GO:0038005","GO:0042676","GO:0048515","GO:0035311","GO:0034620"]},{"accession":"XP_001348034.1","go_terms":[]},{"accession":"XP_966002.1","go_terms":[]},{"accession":"XP_024328950.1","go_terms":["GO:1902600","GO:0009060","GO:0006122","GO:0034551"]}],"graph":[["XP_001348034.1","XP_001347820.2",0.528],["XP_001348034.1","XP_001350458.1",0.642],["XP_001349695.2","XP_001348248.1",0.6],["XP_001349695.2","XP_024329126.1",0.524],["XP_966171.2","XP_001352043.1",0.62],["XP_966171.2","XP_002808884.1",0.573],["XP_002808784.1","XP_001348925.1",0.542],["XP_002808784.1","XP_001350052.1",0.624],["XP_001348925.1","XP_001348845.2",0.605],["XP_002585437.1","XP_024329126.1",0.831],["XP_002585437.1","XP_002585413.1",0.84],["XP_966002.1","XP_001352043.1",0.573],["XP_002585413.1","XP_024329126.1",0.76],["XP_001348845.2","XP_001352043.1",0.705],["XP_024329126.1","XP_001351311.1",0.57],["XP_001348248.1","XP_002808884.1",0.722],["XP_001350052.1","XP_002808970.1",0.523]],"all_go_terms":{"GO:0030968":1,"GO:0019886":1,"GO:0042985":1,"GO:0030163":1,"GO:0042756":1,"GO:0002803":1,"GO:0002018":1,"GO:0006508":1,"GO:0002003":1,"GO:0016540":1,"GO:0002016":1,"GO:0050435":1,"GO:0033619":1,"GO:0070305":1,"GO:0001823":1,"GO:0007586":1,"GO:0045493":1,"GO:0009627":1,"GO:0035311":3,"GO:0048515":3,"GO:0038005":3,"GO:0042676":3,"GO:1904211":3,"GO:0032815":3,"GO:0034620":3,"GO:0006784":1,"GO:1902361":1,"GO:0035774":1,"GO:0061732":1,"GO:0032469":1,"GO:0034975":1,"GO:0002109":1,"GO:0030433":1,"GO:0045648":1,"GO:0010636":1,"GO:0030474":1,"GO:0010216":1,"GO:1902236":1,"GO:0016579":1,"GO:0021888":1,"GO:0034140":1,"GO:1901340":1,"GO:0000028":1,"GO:0000423":1,"GO:0010637":1,"GO:1904049":1,"GO:0071816":1,"GO:1901097":1,"GO:0033132":1,"GO:1900186":1,"GO:1905366":1,"GO:0017085":1,"GO:1901799":1,"GO:0006412":1,"GO:0006289":1,"GO:1902283":1,"GO:0000753":1,"GO:0014070":1,"GO:1904021":1,"GO:0016925":1,"GO:0070842":1,"GO:0006517":1,"GO:0035973":1,"GO:0097237":1,"GO:0006357":1,"GO:1903265":1,"GO:1903071":1,"GO:1904378":1,"GO:0051865":1,"GO:0006890":1,"GO:0006122":1,"GO:0009060":1,"GO:0034551":1,"GO:1902600":1},"recipe_readded":[]}