{"hash":"670445249768873918","title":"Bone Remodeling and Matrix Degradation","description":"The top GO terms cluster around bone and extracellular matrix turnover: collagen catabolic process, bone resorption, and intramembranous ossification point to matrix remodeling and bone turnover. Additional terms related to proteolysis, proteasome storage granule assembly, and autophagy regulation suggest cellular protein turnover accompanying remodeling. Some terms like decidualization and xenobiotic response are less directly related but may reflect broader proteolytic and stress-response activities that accompany matrix remodeling. Overall, the cluster appears to group proteins involved in bone remodeling and extracellular matrix degradation.","confidence":"Medium","size":8,"edges":22,"triangles":30,"max_degree":6,"top_function":null,"members":[{"accession":"XP_001681132.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_001681130.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_001682730.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"XP_001683743.1","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667","GO:0001949","GO:0032286","GO:0006636","GO:0000001","GO:0032443","GO:0006675","GO:0042128","GO:0006809"]},{"accession":"XP_001687650.1","go_terms":["GO:0010205","GO:0070542","GO:0050872","GO:1903699","GO:0034435","GO:1903966","GO:0010873","GO:0046512","GO:0033561","GO:0044130","GO:0006667","GO:0001949","GO:0032286","GO:0006636","GO:0000001","GO:0032443","GO:0006675","GO:0042128","GO:0006809"]},{"accession":"XP_001686023.1","go_terms":["GO:0046718","GO:0051289","GO:1902600","GO:0044257","GO:0009060","GO:0071432","GO:1901143","GO:0032461","GO:0010992","GO:0008286","GO:0051291","GO:0006627","GO:0010815","GO:0042447","GO:0008340","GO:0018189","GO:0006122","GO:0016032","GO:0045861"]},{"accession":"XP_003721587.1","go_terms":["GO:0046718","GO:0051289","GO:1902600","GO:0044257","GO:0009060","GO:0071432","GO:1901143","GO:0032461","GO:0010992","GO:0008286","GO:0051291","GO:0006627","GO:0010815","GO:0042447","GO:0008340","GO:0018189","GO:0006122","GO:0016032","GO:0045861"]},{"accession":"XP_001683476.1","go_terms":["GO:0006633","GO:0001949","GO:0032286","GO:0035754","GO:0080064","GO:0080065","GO:0033490","GO:0006696","GO:0046485","GO:0006675"]}],"graph":[["XP_001687650.1","XP_001681130.1",0.701],["XP_001687650.1","XP_001681132.1",0.685],["XP_001687650.1","XP_001682730.1",0.786],["XP_001687650.1","XP_001683743.1",0.749],["XP_001687650.1","XP_001686023.1",0.61],["XP_001687650.1","XP_003721587.1",0.639],["XP_001681130.1","XP_001681132.1",0.576],["XP_001681130.1","XP_001682730.1",0.635],["XP_001681130.1","XP_001683743.1",0.695],["XP_001681130.1","XP_001686023.1",0.782],["XP_001681130.1","XP_003721587.1",0.76],["XP_001686023.1","XP_001681132.1",0.53],["XP_001686023.1","XP_001683476.1",0.542],["XP_001686023.1","XP_001683743.1",0.684],["XP_001686023.1","XP_003721587.1",0.599],["XP_001682730.1","XP_001681132.1",0.588],["XP_001682730.1","XP_001683476.1",0.589],["XP_001682730.1","XP_001683743.1",0.699],["XP_001682730.1","XP_003721587.1",0.657],["XP_003721587.1","XP_001681132.1",0.612],["XP_003721587.1","XP_001683743.1",0.778],["XP_001681132.1","XP_001683743.1",0.641]],"all_go_terms":{"GO:0046697":3,"GO:0001957":3,"GO:1990237":3,"GO:0042493":3,"GO:0051603":3,"GO:0030574":3,"GO:1903146":3,"GO:0045453":3,"GO:0035593":3,"GO:0060448":3,"GO:0001913":3,"GO:0043129":3,"GO:0009636":3,"GO:0097067":3,"GO:0007614":3,"GO:0050790":3,"GO:0043418":3,"GO:0010813":3,"GO:0071888":3,"GO:0010839":3,"GO:0034769":3,"GO:1903955":3,"GO:2000179":3,"GO:0060441":3,"GO:0006508":3,"GO:1990236":3,"GO:0010815":5,"GO:1903699":2,"GO:0046512":2,"GO:0010205":2,"GO:0001949":3,"GO:0006636":2,"GO:0033561":2,"GO:0034435":2,"GO:1903966":2,"GO:0032286":3,"GO:0042128":2,"GO:0070542":2,"GO:0006809":2,"GO:0044130":2,"GO:0010873":2,"GO:0006667":2,"GO:0006675":3,"GO:0050872":2,"GO:0032443":2,"GO:0000001":2,"GO:0044257":2,"GO:0042447":2,"GO:0051289":2,"GO:0051291":2,"GO:0045861":2,"GO:0008340":2,"GO:0018189":2,"GO:0032461":2,"GO:0016032":2,"GO:0071432":2,"GO:0010992":2,"GO:1901143":2,"GO:0006122":2,"GO:0046718":2,"GO:1902600":2,"GO:0008286":2,"GO:0006627":2,"GO:0009060":2,"GO:0006633":1,"GO:0080064":1,"GO:0006696":1,"GO:0046485":1,"GO:0035754":1,"GO:0033490":1,"GO:0080065":1},"recipe_readded":[]}