{"hash":"1971160609041870249","title":"Redox-Regulated Transcription and ER Stress","description":"This cluster shows a common theme of transcriptional regulation (DNA-templated transcription, RNA Pol II regulation and DNA binding) intertwined with redox biology (deglyutathionylation, cellular oxidant detoxification, and redox homeostasis) and an ER stress response. Together these terms suggest proteins that modulate gene expression in response to oxidative and ER stress, rather than a single metabolic pathway. The presence of both positive/negative transcription regulation terms further supports a regulatory rather than purely catalytic role under stress conditions.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"members":[{"accession":"XP_001685757.1","go_terms":[]},{"accession":"XP_001680891.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]},{"accession":"XP_001686458.1","go_terms":["GO:0046329","GO:0035269","GO:0060049"]},{"accession":"XP_001687720.1","go_terms":["GO:0006659"]},{"accession":"XP_001682359.1","go_terms":[]}],"graph":[["XP_001682359.1","XP_001686458.1",0.782],["XP_001680891.1","XP_001686458.1",0.507],["XP_001685757.1","XP_001686458.1",0.694],["XP_001687720.1","XP_001686458.1",0.832]],"all_go_terms":{"GO:0080058":1,"GO:1903026":1,"GO:0043388":1,"GO:0098869":1,"GO:0045454":1,"GO:0006351":1,"GO:0016032":1,"GO:0000122":1,"GO:0018401":1,"GO:0034976":1,"GO:0030091":1,"GO:0034975":1,"GO:0006662":1,"GO:0034599":1,"GO:0046826":1,"GO:1903206":1,"GO:0055114":1,"GO:0033158":1,"GO:0060049":1,"GO:0035269":1,"GO:0046329":1,"GO:0006659":1},"recipe_readded":[]}