{"hash":"1621743520527421648","title":"Ubiquitin-Mediated Protein Degradation","description":"Dominant theme is ubiquitin-related protein regulation: protein autoubiquitination and K48-linked ubiquitination are present, along with a ubiquitin-dependent ERAD pathway term (noting it is listed as obsolete in the dataset). This points to a cluster centered on marking proteins for degradation. Some secondary terms (Wnt receptor catabolic process, negative regulation of organ growth, peroxisome matrix import) suggest broader links to protein turnover and cellular quality control, while transport terms for methotrexate/folate are less central. Overall, aligns with ubiquitin-mediated protein degradation.","confidence":"High","size":19,"edges":27,"triangles":0,"max_degree":17,"top_function":null,"members":[{"accession":"XP_001682294.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936"]},{"accession":"XP_001683991.1","go_terms":["GO:0006311","GO:0070534","GO:0006915","GO:0060028","GO:1903343","GO:1902187","GO:0043045","GO:0045869","GO:1901536","GO:1904262","GO:0090309","GO:0016925","GO:0010508","GO:0051026","GO:0060669","GO:0034198","GO:0070936","GO:0001825","GO:2000653","GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0060544","GO:0000122","GO:0034121","GO:0043066","GO:0000209","GO:0071157","GO:0033151","GO:0033209","GO:0009048","GO:0036205","GO:0046328","GO:2000620","GO:0042981","GO:0007250","GO:0070512","GO:0085020","GO:0070535","GO:1903265","GO:1903762","GO:1903721","GO:1901253","GO:0090073","GO:0031648","GO:0048147","GO:0006513","GO:0007112","GO:0007285","GO:0010381","GO:0000038","GO:0009640","GO:0048137"]},{"accession":"XP_001681366.1","go_terms":["GO:0015885","GO:0051958"]},{"accession":"XP_001681367.1","go_terms":["GO:0015885","GO:0051958"]},{"accession":"XP_001681368.1","go_terms":["GO:0015885","GO:0051958"]},{"accession":"XP_001682782.1","go_terms":[]},{"accession":"XP_001684421.1","go_terms":[]},{"accession":"XP_001684422.1","go_terms":[]},{"accession":"XP_001684628.1","go_terms":[]},{"accession":"XP_001684781.1","go_terms":["GO:0042073","GO:0060271","GO:0007224"]},{"accession":"XP_001685916.1","go_terms":[]},{"accession":"XP_001686335.1","go_terms":[]},{"accession":"XP_001684122.1","go_terms":[]},{"accession":"XP_003722507.1","go_terms":["GO:0006516","GO:0043687","GO:0043686","GO:0045232","GO:0018279"]},{"accession":"XP_001686604.1","go_terms":["GO:0031118","GO:0031120","GO:0042254","GO:1904874","GO:0000469","GO:0007004"]},{"accession":"XP_001685638.1","go_terms":["GO:0000747","GO:0042274","GO:0000055","GO:0042254","GO:1901001","GO:0002181","GO:1903833","GO:0051301","GO:0006400","GO:0090529","GO:0007049"]},{"accession":"XP_001683703.1","go_terms":[]},{"accession":"XP_001681656.1","go_terms":[]},{"accession":"XP_001685011.1","go_terms":[]}],"graph":[["XP_001686335.1","XP_001683991.1",0.881],["XP_001686335.1","XP_001686604.1",0.775],["XP_001685916.1","XP_001683991.1",0.579],["XP_001685916.1","XP_001686604.1",0.507],["XP_001684421.1","XP_001683991.1",0.712],["XP_001684421.1","XP_001686604.1",0.789],["XP_001683991.1","XP_001681366.1",0.659],["XP_001683991.1","XP_001681367.1",0.714],["XP_001683991.1","XP_001681368.1",0.564],["XP_001683991.1","XP_001682294.1",0.63],["XP_001683991.1","XP_001682782.1",0.738],["XP_001683991.1","XP_001683703.1",0.695],["XP_001683991.1","XP_001684628.1",0.691],["XP_001684781.1","XP_001686604.1",0.838],["XP_001684122.1","XP_001686604.1",0.681],["XP_001685011.1","XP_001686604.1",0.632],["XP_001682782.1","XP_001686604.1",0.684],["XP_001681656.1","XP_001686604.1",0.534],["XP_001681366.1","XP_001686604.1",0.565],["XP_003722507.1","XP_001686604.1",0.533],["XP_001681368.1","XP_001686604.1",0.554],["XP_001685638.1","XP_001686604.1",0.631],["XP_001686604.1","XP_001681367.1",0.617],["XP_001686604.1","XP_001682294.1",0.555],["XP_001686604.1","XP_001683703.1",0.732],["XP_001686604.1","XP_001684422.1",0.513],["XP_001686604.1","XP_001684628.1",0.853]],"all_go_terms":{"GO:1900095":2,"GO:0046621":2,"GO:0030433":2,"GO:0060816":2,"GO:0038018":2,"GO:0051865":2,"GO:0016558":2,"GO:0070936":2,"GO:0042787":2,"GO:0036205":1,"GO:0042981":1,"GO:0006513":1,"GO:0071157":1,"GO:0090073":1,"GO:0007112":1,"GO:0000122":1,"GO:0016925":1,"GO:0000209":1,"GO:0090309":1,"GO:0045869":1,"GO:0043045":1,"GO:0009640":1,"GO:0000038":1,"GO:1903343":1,"GO:0010381":1,"GO:2000653":1,"GO:0007285":1,"GO:0001825":1,"GO:0046328":1,"GO:0033209":1,"GO:0060028":1,"GO:0006311":1,"GO:0060669":1,"GO:0034198":1,"GO:0043066":1,"GO:0007250":1,"GO:1903265":1,"GO:0070535":1,"GO:1901536":1,"GO:1901253":1,"GO:2000620":1,"GO:0033151":1,"GO:1903721":1,"GO:0070512":1,"GO:0031648":1,"GO:0060544":1,"GO:1903762":1,"GO:0009048":1,"GO:0051026":1,"GO:0010508":1,"GO:0048137":1,"GO:0006915":1,"GO:1902187":1,"GO:0048147":1,"GO:0085020":1,"GO:0034121":1,"GO:1904262":1,"GO:0070534":1,"GO:0051958":3,"GO:0015885":3,"GO:0007224":1,"GO:0060271":1,"GO:0042073":1,"GO:0006516":1,"GO:0045232":1,"GO:0043687":1,"GO:0043686":1,"GO:0018279":1,"GO:0042254":2,"GO:1904874":1,"GO:0000469":1,"GO:0031120":1,"GO:0031118":1,"GO:0007004":1,"GO:1901001":1,"GO:0006400":1,"GO:0090529":1,"GO:0002181":1,"GO:1903833":1,"GO:0042274":1,"GO:0007049":1,"GO:0000055":1,"GO:0051301":1,"GO:0000747":1},"recipe_readded":[]}