[{"hash":"47349523948557113","title":"DNA replication and mitotic regulation","description":"The cluster is dominated by GO terms for DNA replication, DNA repair, kinetochore localization, spindle assembly, and regulation of CDK activity, indicating a core cell cycle and mitotic control theme. While there are developmental and inflammatory signaling terms present, they are secondary to the prominent replication/mitosis-related functions. ","confidence":"High","size":29,"edges":16,"triangles":2,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":28},{"id":"GO:0034501","count":27},{"id":"GO:0045736","count":27},{"id":"GO:0048701","count":27},{"id":"GO:0060258","count":26}]},{"hash":"694846583217674249","title":"Cell cycle and vesicle trafficking","description":"Top GO terms reveal a blend of cell division cues (cell cycle, mitotic chromosome condensation, cell division) and endomembrane trafficking (intralumenal vesicle formation, protein retention in Golgi). This suggests a cluster enriched for proteins involved in coordinating mitosis with vesicle trafficking, despite some outlier terms relating to development or stress responses.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070676","count":5},{"id":"GO:0045053","count":5},{"id":"GO:0051301","count":5},{"id":"GO:1902902","count":4},{"id":"GO:0071454","count":4}]},{"hash":"2083644749277232529","title":"Ribosome biogenesis and translation initiation","description":"The top GO terms are dominated by ribosome-related processes (ribosomal large subunit biogenesis, maturation of SSU-rRNA, cytoplasmic translation, regulation of translational initiation, formation of translation preinitiation complex), indicating a core function in assembling ribosomes and initiating protein synthesis. A few terms on apoptosis and cell migration may reflect contextual roles or broader cellular stress responses, but the primary signal is ribosome biogenesis and translation control.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042273","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0033028","count":2}]},{"hash":"1176255160945814775","title":"Developmental gene regulation and signaling","description":"The cluster shows strong representation of multicellular development terms (skin and skeletal system development) and transcription-related processes (DNA-templated transcription, RNA methylation, imprinting regulation), along with signaling and cell-cycle elements (GTPase activity regulation, protein autophosphorylation, ER-stress\u2013related apoptosis). This suggests a cohesive theme of developmental regulation supported by transcriptional control and signaling pathways, rather than a single specific pathway. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0036265","count":9},{"id":"GO:0006351","count":9}]},{"hash":"1063782501566598391","title":"Genome maintenance and protein quality control.","description":"Dominant signals are DNA replication, chromatin assembly (CENP-A), and base-excision repair, pointing to genome maintenance. The presence of aggresome and inclusion body assembly terms suggests concurrent protein quality control, with other terms on transport and respiration being supportive rather than central. ","confidence":"Medium","size":27,"edges":110,"triangles":152,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0006284","count":3},{"id":"GO:0070842","count":3},{"id":"GO:0061641","count":3},{"id":"GO:0006888","count":3}]},{"hash":"139057986704755420","title":"Ribosome Biogenesis","description":"The cluster is enriched for ribosomal large subunit biogenesis and LSU rRNA maturation, suggesting it predominantly contains proteins involved in ribosome assembly and RNA processing. Some transport and signaling terms appear as well, but the strongest signal is ribosome-related, supporting a ribosome biogenesis label.","confidence":"Medium","size":26,"edges":4,"triangles":0,"max_degree":2,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042273","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0000463","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0009432","count":3}]},{"hash":"1338001358228121423","title":"Translation Machinery and Ribosome Biogenesis","description":"Most of the top GO terms are directly about protein synthesis: translation, initiation/elongation/termination, cytoplasmic translation, and ribosome biogenesis, with selenocysteine incorporation\u2014all core components of the translation apparatus. Additional terms like mRNA decay tie into post-transcriptional regulation of translation. A few terms (glial cell proliferation, antibiotic response) are less central but do not alter the dominant theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0042254","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0045901","count":2},{"id":"GO:0006415","count":2}]},{"hash":"484302104950429350","title":"Cell stress and differentiation signals","description":"This cluster includes GO terms spanning fat cell differentiation, response to heat, cell migration, apoptotic processes, and mechanotransduction (response to muscle stretch), along with more general RNA processing and telomere maintenance functions. The common thread is cellular responses to stimuli and differentiation cues, plus some housekeeping/aging related processes, suggesting a loose theme of stress- and differentiation-related signaling rather than a single specific pathway. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045444","count":6},{"id":"GO:0035994","count":6},{"id":"GO:0045736","count":6},{"id":"GO:0006397","count":6},{"id":"GO:1904355","count":6}]},{"hash":"1029434997717488387","title":"Heat stress signaling and ubiquitination in tissues","description":"The top GO terms show a strong emphasis on heat response and temperature detection, paired with ubiquitination and intracellular signaling. This suggests a theme of heat-induced post-translational modification driving signaling pathways that influence tissue-level processes such as endothelial differentiation, adipose tissue regulation, epithelial polarity, and hormonal/secretory responses, rather than a single, tightly focused pathway. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":14},{"id":"GO:0009408","count":13},{"id":"GO:0050960","count":13},{"id":"GO:1903444","count":13},{"id":"GO:0030103","count":13}]},{"hash":"914474467981873251","title":"Heat-stress proteostasis and microtubule organization","description":"The top GO terms cluster around protein quality control, folding, and chaperone activity (ubiquitin-proteasome\u2013related quality control, protein folding, chaperone-mediated assembly) together with tubulin/microtubule assembly and organization, and a heat-response signal (response to heat, thermoception). This points to a function network that maintains protein homeostasis while remodeling the cytoskeleton under heat stress. Some endocrine-related terms appear less central to the core theme but may reflect broader stress signaling. ","confidence":"High","size":26,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071629","count":2},{"id":"GO:0032968","count":2},{"id":"GO:0051131","count":2},{"id":"GO:0006457","count":2},{"id":"GO:0007021","count":2}]},{"hash":"1810698400667479264","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0046677","count":2},{"id":"GO:0090503","count":2},{"id":"GO:0034247","count":2}]},{"hash":"1658348753288546196","title":"Energy Metabolism and Stress Response","description":"The top GO terms cluster around core energy pathways (glycolysis, TCA cycle, carbohydrate phosphorylation) alongside stress-related responses (innate immune response, cellular response to cadmium and hydrogen peroxide). Transcription and cell cycle terms add a growth/maintenance dimension, and photosynthesis hints at broader metabolic context. Together, they suggest a module focused on energy production with concurrent cellular stress signaling and basic gene regulation. ","confidence":"Medium","size":25,"edges":14,"triangles":9,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0061621","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0000278","count":2}]},{"hash":"72623314471238540","title":"RNA Splicing and Translation Regulation","description":"The proteins are enriched for spliceosome-related RNA processing (mRNA splicing, polyadenylation) and multiple facets of translation initiation and reinitiation (including IRES-dependent viral translation, preinitiation complex formation, and regulation of translational initiation), plus ncRNA-mediated gene silencing and stress-related mRNA stability\u2014pointing to a cohesive RNA metabolism and translation-control theme.","confidence":"High","size":25,"edges":106,"triangles":214,"max_degree":21,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0006378","count":10},{"id":"GO:0002188","count":9},{"id":"GO:0045292","count":9}]},{"hash":"2218480651055846711","title":"DNA replication, chromatin assembly, and cell division","description":"This cluster is dominated by core nuclear processes: DNA replication, cell division, and CENP-A\u2013containing chromatin assembly, indicating a cohesive set of proteins involved in genome maintenance and mitosis. The presence of related terms such as viral genome replication and transcription elongation regulation suggests additional linked roles in replication and gene expression. The other terms point to supporting cellular processes like protein quality control (aggresome/inclusion body assembly) and vesicle trafficking (ER to Golgi transport), as well as metabolic remodeling (mitochondrial DNA replication and aerobic respiration) that often accompany cell cycle progression.","confidence":"High","size":24,"edges":149,"triangles":435,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":14},{"id":"GO:0019079","count":13},{"id":"GO:0006260","count":12},{"id":"GO:0070842","count":12},{"id":"GO:0061641","count":12}]},{"hash":"656807747969555146","title":"Methylation and RNA Modification","description":"The cluster is dominated by GO terms tied to methylation across RNA and proteins: tRNA wobble uridine modification, rRNA methylation, histone H4-R3 methylation, and peptidyl-arginine methylation. This points to a common theme around methylation machinery affecting both RNA processing and epigenetic/post-translational regulation. A few other terms (lipid biosynthesis and cell growth) appear less central to this core theme, so the label focuses on the clearest shared function. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0002098","count":2},{"id":"GO:0019919","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0016126","count":2}]},{"hash":"794389426040940774","title":"ER-Golgi Secretory Pathway in Development","description":"This cluster is dominated by terms related to ER to Golgi transport, COPI vesicle coating/budding, and ER lumen protein retention, pointing to secretory pathway components. The presence of maternal development terms (egg-laying, dorsal/ventral axis specification, placenta development) suggests these proteins may be involved in maternal provisioning during oogenesis and early embryogenesis, aligning with secretory trafficking functions. Some terms (behavioral/obsolete) are less informative, but the core theme is consistent.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0048042","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006621","count":2}]},{"hash":"1508186408663009087","title":"Ribosome Biogenesis and Cell Division","description":"The top GO terms cluster around protein synthesis (cytoplasmic translation) and ribosome biogenesis, along with cell division and CENP-A chromatin assembly, suggesting a theme centered on ribosome-related production and the machinery required for mitosis. While a few lineage-specific apoptotic and stress-related terms appear, the dominant signal is the assembly and function of ribosomes and mitotic components.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0051301","count":2},{"id":"GO:2000384","count":1}]},{"hash":"631327394878403352","title":"Ribosome Biogenesis and Translation","description":"The dominating GO terms are rRNA maturation (LSU/5.8S), ribosomal subunit export from the nucleus, mRNA export, translation, and translational initiation, indicating proteins involved in ribosome assembly/processing and the translation machinery; a few trafficking terms may reflect related transport processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0000466","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1066725522308300368","title":"Ubiquitination and Heat Response","description":"The top GO terms show a strong enrichment for ubiquitin-mediated protein modification and degradation (protein ubiquitination and ubiquitin-dependent protein catabolic process), indicating a cluster centered on regulated protein turnover. The presence of thermosensation and heat-response terms (response to heat, detection of temperature stimulus) suggests an additional thermo-regulatory or stress component. Other terms point to broader signaling roles (vitamin D response, vasopressin secretion, endothelial differentiation), but the dominant signal appears to be ubiquitin-mediated regulation with a secondary link to temperature-related stress signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":8},{"id":"GO:0042787","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0009408","count":6},{"id":"GO:0050960","count":6}]},{"hash":"56084535308700855","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000472","count":2}]},{"hash":"269266056499806227","title":"Bacterial lipid catabolism and redox metabolism","description":"The top GO terms revolve around lipid breakdown (phosphatidylserine, monoacylglycerol, triglyceride catabolic processes) and redox-related activities (oxidant detoxification, oxidation-reduction process), suggesting a core theme of lipid metabolism and redox balance. Additional terms for biotin and antibiotic biosynthesis point to broader bacterial metabolic capabilities, with a few regulatory terms (transcription regulation, cell cycle) that may reflect context-dependent regulation. Overall, the cluster appears to center on lipid catabolism and redox metabolism, with ancillary biosynthetic and regulatory associations.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0009102","count":4},{"id":"GO:2000124","count":3},{"id":"GO:0006660","count":3}]},{"hash":"1718901144343774661","title":"Ribosome biogenesis and translation machinery","description":"The cluster centers on translation and ribosome biogenesis, with supporting signals from rRNA maturation/modification and preinitiation complex formation, pointing to proteins involved in assembling and functioning the ribosome and ensuring accurate translation.","confidence":"High","size":22,"edges":217,"triangles":1292,"max_degree":21,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0042254","count":4},{"id":"GO:0006407","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0000462","count":3}]},{"hash":"1148073118611575132","title":"Ribosome Biogenesis and Translation","description":"Label reflects strong signals for cytoplasmic translation, SRP-dependent targeting to membranes, and ribosome biogenesis/assembly, pointing to a group of proteins involved in ribosome production and protein synthesis.","confidence":"High","size":22,"edges":30,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0046632","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0006614","count":1},{"id":"GO:0071353","count":1}]},{"hash":"1744168802839007114","title":"DNA Replication and Cell Cycle","description":"The cluster is dominated by core DNA replication, repair, and mitotic cell cycle terms (including spindle regulation), suggesting proteins involved in DNA maintenance and cell division rather than signaling or development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":20},{"id":"GO:0006281","count":19},{"id":"GO:0000278","count":19},{"id":"GO:0060258","count":18},{"id":"GO:0090169","count":18}]},{"hash":"1219338278030669115","title":"Ubiquitin-Dependent Protein Modification and NF-\u03baB Regulation","description":"The top terms are dominated by ubiquitination processes (K48, K6, K63-linked), protein ubiquitination, and the ERAD pathway, with several items tied to regulation of NF-\u03baB signaling. A peroxisome import term and vitamin D response appear but are less central. Overall, the cluster centers on ubiquitin-mediated protein modification and its connection to NF-\u03baB activity, making this an appropriate, cohesive label.","confidence":"High","size":22,"edges":33,"triangles":22,"max_degree":16,"top_function":"autophagy","top_go_terms":[{"id":"GO:0070936","count":10},{"id":"GO:0030433","count":10},{"id":"GO:0051865","count":9},{"id":"GO:0016567","count":8},{"id":"GO:0085020","count":8}]},{"hash":"644374544159469910","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by terms for ribosome biogenesis and function\u2014small subunit assembly, maturation of SSU rRNA, and translation\u2014suggesting a core role in making and using ribosomes. The presence of deubiquitination and unfolded protein maintenance terms hints at protein quality control linked to ribosome biogenesis and ERAD. A few terms relate to signaling and immune processes, but they appear peripheral to the main ribosome/translation theme.","confidence":"High","size":22,"edges":229,"triangles":1501,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":13},{"id":"GO:0000028","count":7},{"id":"GO:0002109","count":7},{"id":"GO:0006412","count":7},{"id":"GO:1904378","count":7}]},{"hash":"430727450100108386","title":"Organelle biogenesis and vesicle trafficking","description":"This cluster centers on intracellular membrane processes, including melanosome assembly, autophagy, ER-to-Golgi vesicle transport, and exocyst localization, with additional terms for phagosome maturation and organelle inheritance. These shared functions point to a common theme of organelle biogenesis and vesicle trafficking, with related signaling contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903232","count":2},{"id":"GO:0006914","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0042832","count":1},{"id":"GO:0050885","count":1}]},{"hash":"2174940809475092477","title":"Cell growth, transport, and division machinery","description":"This cluster shows prominence of ribosome biogenesis and transcription-related terms alongside vesicle trafficking (ER-Golgi and Golgi-ER), mitotic processes (cell cycle, spindle assembly), and actin remodeling with endocytosis. The mix points to core cellular growth and intracellular transport/mitotic machinery rather than a single specialized pathway, with a couple of terms (e.g., pigmentation) being less central. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1293009707870530440","title":"Spermatogenesis and transcriptional regulation","description":"Top GO terms center on spermatogenesis and male gonad development, accompanied by regulation of transcription by RNA polymerase II, suggesting a germline development program driven by transcriptional control. Other terms (heat response, redox) are present but less cohesive with the main theme.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0006355","count":2}]},{"hash":"1038652849525406064","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":129,"triangles":422,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071277","count":5},{"id":"GO:0000742","count":4},{"id":"GO:0038128","count":4},{"id":"GO:1903861","count":4},{"id":"GO:0090332","count":4}]},{"hash":"1267708517890551295","title":"Cardiovascular development and Wnt signaling","description":"Top terms indicate strong involvement in aorta and coronary vasculature development, i.e., cardiovascular development, along with regulation of canonical Wnt signaling. Additional terms related to mesenchymal stem cell proliferation, cell-matrix adhesion, and embryonic morphogenesis support a broader embryonic development module in which Wnt signaling modulates heart-associated vascular formation. Overall, the cluster centers on cardiovascular development with Wnt pathway regulation.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035904","count":2},{"id":"GO:0060976","count":2},{"id":"GO:0060346","count":1},{"id":"GO:0060828","count":1},{"id":"GO:1902462","count":1}]},{"hash":"2187206851669129062","title":"O-linked glycosylation and cell wall polysaccharide biosynthesis","description":"It is dominated by protein O-linked glycosylation terms (Ser/Thr and GalNAc linkages) and cell-wall polysaccharide biosynthesis (teichoic acid, hyaluronan) with UDP-glucose metabolism; the ER-Golgi transport term appears as an outlier and likely reflects annotation noise.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070940","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0018242","count":1},{"id":"GO:0036108","count":1},{"id":"GO:0006011","count":1}]},{"hash":"194556630089760359","title":"Amino acid catabolism and central metabolism","description":"This cluster mainly features amino acid catabolic processes (e.g., L-alanine, L-kynurenine, glutamate) and central carbon metabolism (oxaloacetate), with supporting biosynthetic pathways, while Notch signaling and insulin response appear as regulatory signals rather than core functions.","confidence":"Medium","size":18,"edges":122,"triangles":443,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042853","count":8},{"id":"GO:0007219","count":7},{"id":"GO:0097053","count":7},{"id":"GO:0009102","count":5},{"id":"GO:0006107","count":5}]},{"hash":"491367063895979915","title":"Nuclear transcription and chromatin remodeling in development","description":"The cluster centers on nuclear gene expression: GO terms for DNA-templated transcription and rDNA heterochromatin formation suggest chromatin-level regulation, while development-related terms like ventricular cardiac morphogenesis and male sex differentiation, plus TGF-beta signaling, point to broader developmental regulatory roles; ancillary terms about protein folding and amyloid formation may reflect stress contexts or chaperone involvement accompanying active transcription and development.","confidence":"Medium","size":18,"edges":116,"triangles":370,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000183","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0055010","count":4},{"id":"GO:0046661","count":4}]},{"hash":"2138321909590255592","title":"Ribosome Biogenesis and Translation Initiation","description":"This cluster is dominated by GO terms tied to ribosome assembly and function, including ribosomal large subunit biogenesis, translational initiation, and SSU-rRNA maturation, along with RNA processing steps like guanine-N7 methylation and mRNA capping, pointing to a core theme of ribosome biogenesis and translation. Extra terms such as antibiotic response and xenobiotic transport suggest stress-related roles that accompany this core function but do not redefine the main theme. ","confidence":"High","size":18,"edges":87,"triangles":170,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0006413","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0006370","count":2}]},{"hash":"628003462195956745","title":"Integrin-mediated adhesion and neural development","description":"The top GO terms cluster around adhesion-related processes (hemidesmosome assembly, integrin-mediated cell adhesion, substrate adhesion-dependent spreading), indicating a cell-adhesion module. Additional terms such as ganglioside metabolism, peripheral nervous system axon regeneration, and associative learning point to neural membrane biology and neural development contexts, with lipid transport regulation suggesting membrane remodeling. Overall, it seems to group proteins involved in adhesion with neural/membrane-related functions.","confidence":"Medium","size":18,"edges":5,"triangles":2,"max_degree":3,"top_function":"wound healing","top_go_terms":[{"id":"GO:0031581","count":8},{"id":"GO:0034446","count":8},{"id":"GO:0010888","count":7},{"id":"GO:0033631","count":7},{"id":"GO:0032369","count":7}]},{"hash":"1539024270680142298","title":"Ribosome Biogenesis and Translation","description":"The cluster's top GO terms center on translation, ribosome biogenesis, rRNA processing, and export of ribosomal subunits, pointing to a coherent role in making and using ribosomes for protein synthesis. Some terms about cell cycle or septum assembly appear but are ancillary to the main ribosome-related function.","confidence":"High","size":18,"edges":26,"triangles":7,"max_degree":9,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0006400","count":6},{"id":"GO:0042274","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0000463","count":4}]},{"hash":"2043762119587311201","title":"Vacuolar amino acid transporters","description":"The top GO terms show multiple transmembrane transport activities for amino acids (arginine, lysine, alanine, proline, glutamine) into and out of the vacuole, which strongly indicates a cluster of vacuolar amino acid transport proteins. A couple of unrelated terms (root cap development, translation) may be incidental annotations, but they do not override the prevailing pattern of amino acid vacuolar transport. ","confidence":"High","size":18,"edges":57,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0090518","count":2},{"id":"GO:1990818","count":2},{"id":"GO:0090452","count":2},{"id":"GO:0090517","count":2}]},{"hash":"233033074532364127","title":"Nuclear export and mitotic regulation","description":"The strongest signals are nuclear export of ribosomal subunits and processes in the mitotic cell cycle, suggesting a cluster focused on coordinating ribosome export with cell division. Additional terms like ubiquitination and regulation of protein kinase activity point to broader regulatory control, but the core theme remains nuclear transport linked to mitosis.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0045859","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0000060","count":2}]},{"hash":"1643782963681668768","title":"Inhibitory Synaptic Transmission and Mitochondrial Dynamics","description":"The top GO terms show strong representation of GABAergic synaptic transmission and negative regulation of excitatory postsynaptic potentials, pointing to neuronal inhibitory signaling. Concurrent mentions of mitochondrial inheritance, distribution, and membrane organization suggest that mitochondrial dynamics accompany this synaptic function, consistent with the energy needs of synapses. Additional terms on endocytic recycling and ephrin signaling fit within neuronal receptor trafficking and signaling. Overall, the cluster appears to couple inhibitory synaptic activity with mitochondrial organization.","confidence":"Medium","size":17,"edges":36,"triangles":21,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0090394","count":3},{"id":"GO:0051932","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0060047","count":3},{"id":"GO:0032456","count":3}]},{"hash":"19658992247929116","title":"Developmental gene regulation and ER stress apoptosis","description":"The cluster is enriched for development-related GO terms (multicellular organism development, forebrain development, neural tube closure) and transcriptional regulation (DNA-templated transcription, regulation of gene expression). There is also a signal of cellular stress responses, notably intrinsic apoptotic signaling in response to ER stress, suggesting these proteins may coordinate developmental gene regulation with stress-induced apoptosis. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0006349","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0001843","count":4}]},{"hash":"2273319478896901583","title":"Neural Development and Immune Signaling","description":"The prominent terms include cerebellum development and fasciculation of motor neuron axons, indicating neural developmental processes, while Fc receptor signaling and interleukin-1\u2013mediated signaling point to immune signaling; KIT signaling and chemotaxis add broader signaling context. Together they suggest a cluster of proteins involved in neural development with associated immune and signaling pathways, with DNA repair and spindle regulation appearing as background cellular processes.","confidence":"Medium","size":17,"edges":91,"triangles":218,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":17},{"id":"GO:0038093","count":17},{"id":"GO:0006281","count":17},{"id":"GO:0090169","count":17},{"id":"GO:0038109","count":17}]},{"hash":"2125517275579481199","title":"Immune signaling and neuronal guidance","description":"The top GO terms point to signaling pathways tied to immune responses (Fc receptor signaling, interleukin-1 signaling, chemotaxis, peptide hormone response, Kit signaling) and neural development (fasciculation of motor neuron axons), suggesting a cluster of proteins involved in signaling in immune and neural contexts. Some other terms (DNA repair, spindle assembly) may reflect general cellular processes but do not contradict the central theme. ","confidence":"Medium","size":17,"edges":105,"triangles":309,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046827","count":17},{"id":"GO:0060258","count":16},{"id":"GO:0038093","count":16},{"id":"GO:0006281","count":16},{"id":"GO:0090169","count":16}]},{"hash":"2241719706603071034","title":"Unknown","description":"The top GO terms include DNA-templated transcription, mRNA transport, TORC1 signaling, negative regulation of Wnt signaling, regulation of focal adhesion, proton transmembrane transport, and vacuole inheritance, among others. The terms span transcription, signaling, transport, and development with no single cohesive function or pathway evident, suggesting a mixed cluster rather than a unified function.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000011","count":2},{"id":"GO:0048496","count":2},{"id":"GO:0015991","count":2},{"id":"GO:0000060","count":2}]},{"hash":"1528293029562059044","title":"Unknown","description":"The GO terms are highly diverse, covering DNA repair, spindle assembly regulation, inflammatory signaling, hormone response, chemotaxis, and several development-related processes (cerebellum and labyrinthine layer vascular development). There isn\u2019t a single cohesive biological theme that clearly unites these terms, so a concise, reliable cluster label cannot be confidently assigned.","confidence":"","size":17,"edges":26,"triangles":5,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":17},{"id":"GO:0006281","count":17},{"id":"GO:0090169","count":17},{"id":"GO:0006935","count":17},{"id":"GO:0070498","count":17}]},{"hash":"1350469961279411056","title":"Lung branching morphogenesis and ECM remodeling","description":"This cluster is dominated by terms tied to extracellular matrix (ECM) remodeling and lung development, including collagen catabolic process and basement membrane disassembly, as well as epithelial tube branching and lung morphogenesis terms. The presence of proteolysis-related terms (bradykinin and neuropeptide catabolic processes) supports a theme of proteolytic regulation during morphogenesis, with a broader nod to developmental remodeling (e.g., intramembranous ossification). Overall, the strongest signal points to lung morphogenesis coupled with ECM turnover. ","confidence":"Medium","size":17,"edges":114,"triangles":414,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0051603","count":6},{"id":"GO:0010815","count":6},{"id":"GO:0030574","count":6},{"id":"GO:2000179","count":6},{"id":"GO:0060448","count":6}]},{"hash":"1129706218837175043","title":"Developmental Kinase Signaling","description":"The top GO terms emphasize regulation of signaling enzymes\u2014such as positive regulation of GTPase activity and protein serine/threonine kinase activity\u2014alongside developmental processes (multicellular organism development and skin development). This points to a cluster of proteins involved in signaling control during development, including kinase- and autophosphorylation-related regulation. While some terms also indicate stress responses, the core theme appears to be developmental kinase signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0031954","count":7},{"id":"GO:0071902","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0043588","count":6}]},{"hash":"1014955277760865868","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":34,"triangles":31,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0000480","count":8},{"id":"GO:0000462","count":8},{"id":"GO:0000463","count":8},{"id":"GO:0042273","count":8}]},{"hash":"918675048870602585","title":"DNA replication and repair cluster","description":"The top GO terms are dominated by DNA replication, DNA unwinding, and nucleotide-excision repair, with SOS-like damage response and transcription initiation terms, suggesting a network of genome maintenance and stress response functions. Some terms like nonsense-mediated decay and viral genome replication appear as additional contextual signals but do not override the core theme. Overall, this cluster aligns with DNA replication/repair and damage response pathways.","confidence":"Medium","size":16,"edges":14,"triangles":1,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":10},{"id":"GO:0000184","count":8},{"id":"GO:0009432","count":7},{"id":"GO:0006268","count":7},{"id":"GO:0019079","count":7}]},{"hash":"926052666592975566","title":"Developmental Signaling and Cell Cycle","description":"These proteins show both core cell-cycle processes (DNA replication, DNA repair, spindle assembly) and diverse signaling/developmental roles (KIT signaling, Fc receptor signaling, IL-1\u2013mediated signaling, chemotaxis, and neural crest-related morphogenesis). The cluster seems to integrate cell division with developmental and immune/neuronal signaling, though the connection is broad rather than a single pathway. ","confidence":"Medium","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":16},{"id":"GO:0048701","count":16},{"id":"GO:0060258","count":15},{"id":"GO:0038093","count":15},{"id":"GO:0006281","count":15}]},{"hash":"2060268228615892229","title":"Core cellular biosynthesis and quality control","description":"This cluster centers on fundamental cellular processes: DNA replication, cell division, ribosome large subunit assembly, chaperone-assisted refolding, and proteasome/ERAD\u2013related quality control, i.e., core biosynthesis and proteostasis. The vesicle transport and motility terms appear as related cellular logistics but do not define the main theme.","confidence":"Medium","size":16,"edges":48,"triangles":62,"max_degree":14,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0015979","count":5},{"id":"GO:0000027","count":4},{"id":"GO:0003341","count":4}]},{"hash":"1169252996081389533","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":117,"triangles":519,"max_degree":15,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":5},{"id":"GO:0006351","count":3},{"id":"GO:2000623","count":3},{"id":"GO:1904571","count":3}]},{"hash":"677510980745118659","title":"Plant secondary metabolism and detoxification","description":"This cluster shows links to plant secondary metabolite biosynthesis (strigolactone, alkaloid) and detoxification/metabolism of xenobiotics (glucuronoside catabolic process, response to toxic substance, beta-ketoadipate pathway, antibiotic biosynthetic process). Together they suggest a metabolic module focused on small-molecule production and degradation rather than a single unified pathway; some terms (e.g., endocannabinoid signaling regulation) may reflect broader annotations but do not override the overarching theme. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":3},{"id":"GO:0046839","count":2},{"id":"GO:1990577","count":2},{"id":"GO:1901601","count":2},{"id":"GO:0042952","count":2}]},{"hash":"1657169254151629299","title":"Vesicle trafficking and secretory pathway regulation","description":"The cluster centers on endocytosis, phagosome maturation, and regulation of secretory pathways, indicating a shared role in vesicle trafficking and intracellular transport. Several development-related terms (keratinocyte development, osteoblast proliferation, interneuron migration) suggest these trafficking processes are important across diverse tissues during development, making a cohesive theme of vesicle trafficking and regulated secretion in developing cells. ","confidence":"Medium","size":16,"edges":47,"triangles":32,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0090382","count":2},{"id":"GO:0003334","count":2},{"id":"GO:0045859","count":2}]},{"hash":"1020581295828763960","title":"Cytoskeleton Assembly and Proteostasis","description":"The strongest signals are tubulin complex assembly and cortical microtubule organization, suggesting a cytoskeletal focus. Protein folding and chaperone-mediated assembly along with ubiquitin-proteasome\u2013dependent quality control point to proteostasis that supports cytoskeletal maintenance. Development-related terms (nervous system, keratinocyte development) likely reflect cytoskeletal roles in cell differentiation and tissue formation, with other terms like phagosome maturation hinting at cytoskeleton-\u2013driven trafficking. Overall, the cluster seems centered on cytoskeletal assembly coupled with proteostasis during development and remodeling.","confidence":"Medium","size":16,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007021","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0071629","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0051131","count":1}]},{"hash":"1143594301500550096","title":"RNA processing and mRNA metabolism","description":"This cluster is dominated by GO terms tied to RNA maturation and turnover: RNA polymerase II transcription termination, histone mRNA metabolism, spliceosomal assembly and mRNA splicing, deadenylation-dependent decapping, and P-body assembly. These signal strong involvement in RNA processing and mRNA decay pathways, suggesting a cohesive group of factors coordinating RNA maturation and turnover, with additional hints toward chromatin maintenance and cell-cycle-related processes.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006369","count":12},{"id":"GO:0008334","count":8},{"id":"GO:0009737","count":8},{"id":"GO:0000245","count":8},{"id":"GO:0045292","count":8}]},{"hash":"870112911530893391","title":"ECM proteolysis in organ morphogenesis","description":"The cluster is dominated by proteolysis-related GO terms (proteolysis, bradykinin catabolic, collagen catabolic, neuropeptide catabolic) and basement membrane disassembly, alongside morphogenetic processes such as lung epithelial tube branching and branching morphogenesis. This pattern points to extracellular matrix remodeling and controlled protein degradation driving developmental tissue morphogenesis, including lung and bone-related remodeling contexts (e.g., intramembranous ossification). Confidence in this thematic link is moderate to high given the recurring emphasis on matrix degradation and organ morphogenesis.","confidence":"Medium","size":15,"edges":40,"triangles":28,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0051603","count":4},{"id":"GO:0010815","count":4},{"id":"GO:0030574","count":4},{"id":"GO:2000179","count":4},{"id":"GO:0060448","count":4}]},{"hash":"1668438510742885478","title":"Mitotic spindle assembly and cytokinesis","description":"Top terms cluster around cell division and microtubule-based spindle functions, including mitotic spindle assembly, cytokinesis, and spindle pole duplication. A neuron migration term is occasionally linked to microtubule dynamics, but the dominant signal here is mitotic machinery. This label captures the core function of the cluster.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0031122","count":3},{"id":"GO:0043093","count":3},{"id":"GO:0051256","count":3}]},{"hash":"2072568412425619474","title":"Ribosome biogenesis and translation","description":"Dominant terms are ribosome-related: ribosomal large subunit assembly, biogenesis, export from nucleus, and cytoplasmic translation, plus overall translation. This points to a cluster of proteins involved in ribosome production and core protein synthesis, with a few drug-response terms appearing as secondary associations. ","confidence":"High","size":15,"edges":101,"triangles":407,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0000027","count":4},{"id":"GO:0042273","count":3},{"id":"GO:0000055","count":2},{"id":"GO:0002181","count":2}]},{"hash":"1837638884433772772","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":11,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0050830","count":2}]},{"hash":"313284620941714079","title":"Unknown","description":"Top GO terms cover diverse domains: epithelial polarity, hepatocyte and myeloid apoptosis, cell migration, heat response/thermoception, adipocyte differentiation regulation, vasopressin secretion, venous endothelial differentiation, and general multicellular processes. The breadth of functions implies no single cohesive function or pathway ties these proteins together. Because of this lack of a unifying theme, a specific, high-confidence label cannot be assigned.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0097284","count":3},{"id":"GO:0033028","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0009408","count":2}]},{"hash":"1686179986151784903","title":"Unknown","description":"The terms span transcription, chromatin assembly, translation initiation, protein degradation, and various cell cycle/apoptosis processes, with no single cohesive function linking all proteins. The lack of edges and the heterogeneous GO terms support labeling as Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0061641","count":1},{"id":"GO:0051402","count":1},{"id":"GO:0010659","count":1}]},{"hash":"1867855959118274216","title":"Heat response and thermoregulation","description":"The most prominent terms are heat response and detection of temperature stimulus (thermoception), pointing to a thermal stress/thermoregulatory theme. Additional terms touch on adipose (brown fat) differentiation, vasopressin secretion, and vascular/epithelial processes, suggesting a broader physiological network around maintaining homeostasis in response to temperature, with regulatory layers like ubiquitination and intracellular signaling. Overall, the cluster centers on how cells and tissues respond to heat and regulate temperature-driven physiology.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0009408","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0030103","count":2}]},{"hash":"1434924468650194950","title":"Immune receptor signaling and chemotaxis","description":"The top GO terms cluster around receptor-mediated signaling pathways (Fc receptor signaling, interleukin-1 signaling, Kit signaling, cellular response to peptide hormone stimulus) and processes like chemotaxis and axon fasciculation, suggesting a shared theme of signaling that directs immune-related responses and cell movement; a few terms (DNA repair, spindle assembly) are less connected to this theme but do not override the overall pattern.","confidence":"Medium","size":14,"edges":72,"triangles":193,"max_degree":13,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":11},{"id":"GO:0046827","count":11},{"id":"GO:0060258","count":10},{"id":"GO:0038093","count":10},{"id":"GO:0090169","count":10}]},{"hash":"1177614998821715049","title":"Cardiac and Venous Endothelial Development","description":"Based on several GO terms centered on heart morphogenesis and venous endothelial differentiation (e.g., cardiac right atrium morphogenesis, Notch signaling in heart field cardioblast proliferation, venous endothelial cell differentiation), the cluster appears to group proteins involved in cardiovascular development and endothelial differentiation. A few lipid biosynthesis terms are present, but the strongest signal points to heart/vascular development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060843","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0003213","count":2},{"id":"GO:0003270","count":2},{"id":"GO:0010923","count":1}]},{"hash":"435240445936612341","title":"Integrin-mediated adhesion and hemidesmosome assembly","description":"The cluster is dominated by adhesion-related terms (integrin-mediated cell adhesion, hemidesmosome assembly, substrate adhesion-dependent spreading), pointing to a core function in cell\u2013ECM interactions and tissue remodeling; several other terms (lipid regulation, associative learning, T cell migration) appear less central to this theme.","confidence":"Medium","size":13,"edges":17,"triangles":3,"max_degree":6,"top_function":"wound healing","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0071318","count":8},{"id":"GO:0010888","count":7},{"id":"GO:0033631","count":7},{"id":"GO:0031581","count":7}]},{"hash":"2164342192007924761","title":"Meiosis and Kinetochore Localization Proteins","description":"The cluster shows strong enrichment for meiotic cell cycle and kinetochore localization terms (GO:0051321, GO:0034501), suggesting involvement in chromosome segregation during meiosis. While other terms (neuron differentiation, morphine response, brassinosteroid signaling) are heterogeneous, the dominant theme is meiosis-associated cell-cycle control and kinetochore functions.","confidence":"Medium","size":13,"edges":71,"triangles":217,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034501","count":8},{"id":"GO:0030182","count":8},{"id":"GO:0006685","count":7},{"id":"GO:0001915","count":7},{"id":"GO:0006196","count":7}]},{"hash":"242214414029923600","title":"Unknown","description":"The top GO terms are diverse, including immune signaling (Fc receptor signaling, interleukin-1 signaling), neuronal development (cerebellum development, motor neuron axon fasciculation), DNA repair, and various signaling pathways (Kit, peptide hormone signaling, chemotaxis). There is no clear, cohesive biological theme linking all these functions, so a single descriptive label cannot be confidently assigned.","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":12},{"id":"GO:0038093","count":12},{"id":"GO:0006281","count":12},{"id":"GO:0090169","count":12},{"id":"GO:0038109","count":12}]},{"hash":"52059720521445480","title":"Vacuolar amino acid transport","description":"The GO terms show multiple amino acid transmembrane transport processes into and out of the vacuole (arginine, lysine, proline, alanine, glutamine), plus a general transporter/ion transport term (lithium). This points to a coordinated set of proteins functioning in vacuolar amino acid homeostasis, with root cap development possibly reflecting plant-specific vacuolar roles in root cells. The wybutosine biosynthetic process is an outlier, but the dominant theme is clear: vacuolar transport of amino acids.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031591","count":2},{"id":"GO:0090518","count":2},{"id":"GO:1990818","count":2},{"id":"GO:0090452","count":2},{"id":"GO:0090517","count":2}]},{"hash":"356922485391969530","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by translation-related GO terms (translation, cytoplasmic translation) and ribosome biogenesis/assembly (ribosome biogenesis, ribosomal large subunit biogenesis, ribosomal large subunit assembly, maturation of SSU-rRNA), indicating a shared function in making and utilizing ribosomes for protein synthesis. Minor hints of splicing regulation are present but not central. Confidence: High","confidence":"","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0046677","count":3},{"id":"GO:0002181","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0042273","count":2}]},{"hash":"2298368359224395413","title":"Unknown","description":"The top GO terms show a mix of temperature- and heat-related terms alongside diverse processes such as vascular/adipose differentiation, chemokine production, epithelial polarity, intracellular signaling, and chloroplast protein import. There is no single cohesive function linking all proteins, and the network has no edges or clusters to support a unified biological role. Therefore this cluster cannot be assigned a specific label with confidence.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0050960","count":4},{"id":"GO:1903444","count":4},{"id":"GO:0030103","count":4},{"id":"GO:0060843","count":4}]},{"hash":"1407660872631143492","title":"Cell signaling and tissue differentiation","description":"This cluster centers on intracellular signal transduction and processes related to tissue organization, such as epithelial polarity and endothelial differentiation, with supporting terms for hormone secretion and chemokine production. The mix of signaling and differentiation terms suggests a broad, coordinating role in cellular communication and tissue development rather than a single specific pathway. Confidence: Medium","confidence":"","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0009408","count":1},{"id":"GO:0050960","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0030103","count":1}]},{"hash":"1992693780215651911","title":"RNA methylation and ribosome maturation","description":"The top GO terms cluster around RNA modifications (rRNA and tRNA methylation, rRNA maturation, and related methyltransferase activity), suggesting a shared function in RNA processing and ribosome biogenesis. Some terms (ER targeting, signal peptide processing) are less coherent with this theme and may reflect annotation noise or multi-functionality; a hypoxia response term appears as an outlier. Overall, the dominant signal supports RNA modification and ribosome maturation as the cluster\u2019s theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900039","count":1},{"id":"GO:0035103","count":1},{"id":"GO:0070476","count":1},{"id":"GO:0000470","count":1},{"id":"GO:0030488","count":1}]},{"hash":"1865073586239101512","title":"Chromatin assembly and ribosome biogenesis","description":"The cluster is dominated by terms for ribosome biogenesis and ribosomal subunit assembly, along with DNA-templated transcription and chromatin-related processes such as histone methylation and CENP-A\u2013containing chromatin assembly. These together suggest a cohesive nuclear program coordinating chromatin organization with transcription and ribosome production; some apoptotic terms in neural and cardiac tissues appear as peripheral associations rather than core functions.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0034729","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0000027","count":2}]},{"hash":"2141351833315208985","title":"Cytoskeleton-driven mitosis and organelle movement","description":"This cluster centers on cytoskeletal organization and its roles in mitosis and organelle movement. The top GO terms converge on spindle assembly and separation, kinetochore-microtubule interactions, and actomyosin contractile ring formation, alongside processes like karyogamy and chloroplast movement, all of which are mediated by the cytoskeleton. Plant- and neuron-related terms (root development, neuron projection maintenance) can be linked through shared cytoskeletal dynamics and transport processes, suggesting a unifying theme of cytoskeletal control of cell division and intracellular trafficking across species.","confidence":"High","size":11,"edges":34,"triangles":48,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":10},{"id":"GO:0048364","count":9},{"id":"GO:1990535","count":9},{"id":"GO:0051255","count":9},{"id":"GO:0007100","count":9}]},{"hash":"1076974505196162384","title":"Golgi-Driven Vesicle Trafficking and Synaptic Exocytosis","description":"This cluster is dominated by GO terms for ER-to-Golgi and intra-Golgi transport, SNARE complex assembly, vesicle fusion with the Golgi, and exocytic insertion of neurotransmitter receptors, all pointing to proteins coordinating secretory pathway trafficking to the plasma membrane and synaptic receptor turnover, with links to synaptic potentiation.","confidence":"High","size":11,"edges":24,"triangles":21,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0035493","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0098967","count":3},{"id":"GO:0060291","count":3}]},{"hash":"2069575045247585110","title":"Nuclear DNA replication and mitosis cluster","description":"The top GO terms are dominated by nuclear processes: DNA replication, DNA repair, DNA-templated transcription, mitotic cell cycle, spindle assembly, and export from the nucleus. While there are a few signaling-related terms (Fc receptor, Kit signaling, chemotaxis), the core theme centers on genome maintenance and cell division in the nucleus, so the label reflects the predominant function of the cluster.","confidence":"High","size":11,"edges":12,"triangles":2,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006281","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0046827","count":7}]},{"hash":"818457154397537561","title":"Unknown","description":"The top GO terms span wound response, lipid metabolism, snoRNP assembly, immune signaling, DNA repair, heat response, spindle assembly regulation, and thermoception, showing no single shared function. With zero edges among the proteins, there is no cohesive theme to tie the proteins into a meaningful label.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009611","count":2},{"id":"GO:0016042","count":1},{"id":"GO:0000492","count":1},{"id":"GO:0060258","count":1},{"id":"GO:0038093","count":1}]},{"hash":"135058906436592048","title":"Thermogenic Heat-Response and Adipose Signaling","description":"The top GO terms center on heat response and temperature sensing (response to heat; detection of temperature stimulus) with brown fat cell differentiation suggesting thermogenic adipose function, plus related endocrine/vascular processes (vasopressin secretion, endothelial differentiation) and general signaling. This points to a cohesive theme of temperature-driven signaling linked to adipose tissue and related systems, despite some broader terms. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904357","count":4},{"id":"GO:0009408","count":3},{"id":"GO:0050960","count":3},{"id":"GO:1903444","count":3},{"id":"GO:0030103","count":3}]},{"hash":"100031326177452954","title":"ECM Remodeling in Branching Morphogenesis","description":"The GO terms point to proteolysis of extracellular matrix components (collagen, basement membrane) and general protease-mediated remodeling, coupled with branching morphogenesis in epithelia and lungs. This combination suggests a cluster of proteins involved in extracellular matrix remodeling that facilitates tissue branching. A broad developmental label like ECM remodeling in branching morphogenesis best captures the shared function without overreaching into unrelated processes.","confidence":"Medium","size":11,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051603","count":5},{"id":"GO:0010815","count":5},{"id":"GO:0030574","count":5},{"id":"GO:2000179","count":5},{"id":"GO:0060448","count":5}]},{"hash":"744612362620409399","title":"Immune signaling and keratinocyte differentiation","description":"This cluster is characterized by immune-related GO terms such as T cell receptor signaling, Fc receptor signaling, and neutrophil clearance, indicating proteins involved in immune cell signaling. The presence of keratinocyte differentiation suggests a link to epidermal cell biology, so the common theme appears to be signaling pathways that regulate immune responses and skin cell differentiation, with some Wnt pathway regulation terms adding to the signaling modulation theme. Some other terms (salt stress, actin cytoskeleton) seem less cohesive with the main theme and may reflect broader or overlapping roles in signaling.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090090","count":2},{"id":"GO:0050852","count":2},{"id":"GO:0051436","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0097350","count":2}]},{"hash":"909931053613489854","title":"Nuclear transport and genome organization","description":"The terms point to nuclear architecture and RNA trafficking: mRNA and tRNA export, nuclear pore complex assembly, and tethering of chromatin/genes at the nuclear periphery, including telomere organization. Additional terms reflect developmental signaling and hematopoiesis contexts where such nuclear processes are active, suggesting a cluster of proteins involved in maintaining nuclear organization and RNA transport during development and immune-related processes.","confidence":"Medium","size":10,"edges":19,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0034398","count":1},{"id":"GO:0035167","count":1},{"id":"GO:0000973","count":1},{"id":"GO:0009870","count":1},{"id":"GO:0051292","count":1}]},{"hash":"540595255547433190","title":"Unknown","description":"There are no GO terms listed (Top Terms is empty) and no edges or triangles, so there is no detectable functional signal connecting these proteins. Without functional terms or interaction data, a coherent thematic label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1403674851204096335","title":"Gene Expression and Chromatin Assembly","description":"The proteins are linked to transcription (DNA-templated transcription), transcription machinery, translation initiation complex formation, and CENP-A\u2013dependent chromatin assembly, with additional ties to meiotic nuclear division. This points to a shared role in nuclear gene expression control and chromatin dynamics; developmental and apoptotic terms appear as secondary contexts. ","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":3},{"id":"GO:0000920","count":3},{"id":"GO:0061641","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0010659","count":2}]},{"hash":"32627025571652235","title":"Bacterial cell cycle and peptidoglycan biosynthesis","description":"This cluster is enriched for GO terms tied to the bacterial cell cycle and cell division (cell cycle, DNA-templated DNA replication initiation, cell division) alongside terms for peptidoglycan biosynthesis and Gram-negative cell wall biogenesis (peptidoglycan biosynthetic process, cell wall organization, Gram-negative-bacterium-type cell wall biogenesis). This co-occurrence suggests proteins that coordinate DNA replication and division with wall synthesis, a hallmark of bacterial cytokinesis and cell wall assembly, supporting a label focused on bacterial cell cycle\u2013coupled cell wall biosynthesis. Some terms are obsolete, but the dominant theme remains cell cycle with wall production.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0008360","count":1},{"id":"GO:0009252","count":1},{"id":"GO:0006486","count":1}]},{"hash":"960075972078725553","title":"DNA replication, repair, and mitosis regulation","description":"The top GO terms point to DNA replication, DNA repair, and regulation of spindle assembly, indicating a core theme of genome maintenance during cell division. Ionizing radiation response also supports a DNA damage response connection, with other signals (developmental pathways, receptor signaling) likely secondary. Overall, the cluster seems driven by processes tied to cell cycle and genome integrity.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901621","count":2},{"id":"GO:0071479","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0071374","count":2},{"id":"GO:0001707","count":2}]},{"hash":"1620982023202657380","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000398","count":8},{"id":"GO:0000480","count":8},{"id":"GO:0000462","count":8},{"id":"GO:0000463","count":8},{"id":"GO:0042273","count":8}]},{"hash":"1184999053052998485","title":"Chromatin and Proteostasis","description":"Top GO terms converge on nuclear processes such as DNA-templated transcription and CENP-A chromatin assembly, alongside proteostasis-related terms like proteasome regulatory particle assembly and aggresome assembly. Additional signals for phosphorylation, translational fidelity regulation, and various protein modifications suggest coordinated control of gene expression and proteome maintenance. Mitochondrial DNA replication and epithelial polarity appear more peripheral, indicating the core theme is genome-associated regulation coupled with protein quality control rather than a single, focused pathway.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0070682","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0006450","count":1}]},{"hash":"661740193540239022","title":"Heat Sensing and Thermoregulation","description":"Dominant GO terms are heat response and temperature detection (thermoception), suggesting a heat-sensing and thermoregulatory function. The presence of brown fat differentiation and vasopressin secretion aligns with metabolism and hormonal control of temperature. Other terms are broad or cross-species annotations, but the core theme remains thermal response and temperature signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":1},{"id":"GO:0050960","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0030103","count":1},{"id":"GO:0060843","count":1}]},{"hash":"2229642700434049667","title":"Thermal response and tissue differentiation signaling","description":"The terms cluster around heat/temperature sensing (response to heat, detection of temperature stimulus) with supporting processes in cytoskeletal remodeling, vascular/endothelial differentiation, epithelial polarity, vasopressin secretion, and chemokine production, pointing to coordinated thermoregulation linked to tissue remodeling and signaling. The inclusion of brown fat differentiation regulation reinforces a thermogenic context, though the terms span multiple tissues, so this is a broader thermal-response/tissue-signaling cluster rather than a single specific function. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051017","count":5},{"id":"GO:0009408","count":4},{"id":"GO:0050960","count":4},{"id":"GO:1903444","count":4},{"id":"GO:0030103","count":4}]},{"hash":"599132731153927759","title":"Unknown","description":"This cluster has no GO terms, no edges or triangles, and no enriched functional signal, so there is no clear shared function to name. The 3 proteins re-added by ReCIPE do not provide enough context to assign a meaningful theme.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"946434899882410830","title":"Heat- and immune-stress response","description":"This cluster shows a clear enrichment for temperature/heat-related terms (response to heat, detection of temperature stimulus, heat-stress transcriptional regulation) alongside immune signaling terms (defense response to Gram-positive bacteria, Fc receptor signaling, Kit signaling). A few terms like skeletal development and DNA repair are peripheral, suggesting some multifunctionality but the dominant theme is heat-induced and immune signaling. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0061408","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0060258","count":1},{"id":"GO:0038093","count":1}]},{"hash":"1205264382591312042","title":"ER\u2013Golgi Secretory Pathway Components","description":"Top GO terms point to processes in the early secretory pathway: ER-to-Golgi transport, COPI-coated vesicles, ER lumen protein retention, and related organelle acidification, with a few developmental-role terms that may reflect secreted factors or broader annotations. Overall, the cluster seems to group proteins involved in the secretory pathway and vesicle-mediated trafficking between ER and Golgi.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":1},{"id":"GO:0000032","count":1},{"id":"GO:0016049","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0048042","count":1}]},{"hash":"114551375299135180","title":"Unknown","description":"The top GO terms span diverse processes\u2014protein autophosphorylation, tetrapyrrole linkage, DNA replication, chemotaxis, various signaling pathways, and immune-related regulation. With only single, scattered annotations among 9 proteins, there is no clear shared function tying the cluster together. As a result, the cluster cannot be assigned a specific, cohesive biological theme (Unknown).","confidence":"","size":9,"edges":13,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0018298","count":1},{"id":"GO:1903660","count":1},{"id":"GO:0046777","count":1},{"id":"GO:0017006","count":1},{"id":"GO:0006261","count":1}]},{"hash":"598339674944494710","title":"Unknown","description":"The GO terms are highly diverse with no obvious shared function tying the nine proteins together (e.g., DNA repair, heat response, spindle regulation, multiple signaling pathways, chemotaxis, axon guidance). Because there is no cohesive theme, a single, representative label cannot be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060258","count":1},{"id":"GO:0038093","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0090169","count":1}]},{"hash":"642685841132329140","title":"Ubiquitin-Dependent Proteolysis and ER Stress Response","description":"The top terms are dominated by ubiquitin-mediated protein degradation and ERAD, plus a translation initiation response under ER stress, pointing to a proteostasis/quality-control focus. There are additional signals related to trafficking to membranes (photoreceptor outer segment localization) and defense pathways (innate immunity and antiviral responses), suggesting stress signaling intersecting with proteostasis. Overall, this cluster best represents proteostasis and ER-stress\u2013linked responses, with possible membrane targeting and defense connections.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0030433","count":2},{"id":"GO:1903546","count":1},{"id":"GO:0036494","count":1}]},{"hash":"2249456720935591303","title":"Unknown","description":"The GO terms include lipid catabolism, immune regulation, plant hormone signaling, morphine response, cell migration/EMT, meiosis, and DNA damage control, which do not converge on a single shared function. Because of this diversity, there isn't a clear, cohesive theme to label the cluster with a specific biological function.","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006685","count":8},{"id":"GO:0001915","count":8},{"id":"GO:0006196","count":8},{"id":"GO:0009742","count":8},{"id":"GO:0031987","count":8}]},{"hash":"2092809182275248496","title":"Brown Fat Differentiation and Heat Response","description":"The terms show a focus on adipose tissue biology\u2014fat cell differentiation and specifically brown fat differentiation\u2014along with thermogenesis and temperature sensing (response to heat and detection of temperature stimulus). Additional signals related to endocrine and intracellular signaling are present, which supports a broader context of brown fat\u2013associated thermogenic regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":3},{"id":"GO:0009408","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0030103","count":2}]},{"hash":"1738684652440035294","title":"SRP-dependent cotranslational membrane targeting","description":"This cluster is defined by GO terms describing SRP-dependent cotranslational protein targeting to the membrane and translocation, indicating components of the SRP pathway that direct nascent polypeptides to the membrane. With no other shared functions observed, the label succinctly captures the common function of these proteins.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006614","count":1},{"id":"GO:0006616","count":1}]},{"hash":"192211077132065184","title":"Cell Cycle and Mitosis Regulation","description":"The cluster is dominated by GO terms tied to cell cycle progression and mitosis, including G1/S and G2/M transitions, mitotic spindle pole separation, and chromosome condensation via histone modification. Additional terms reference DNA-templated transcription and growth signaling (insulin receptor pathway, mammary gland cell proliferation), suggesting a cohesive theme around proliferative regulation and mitotic control. This supports labeling as Cell Cycle and Mitosis Regulation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046626","count":4},{"id":"GO:0006351","count":4},{"id":"GO:2000775","count":4},{"id":"GO:0000320","count":4},{"id":"GO:0033598","count":4}]},{"hash":"638523147390015568","title":"RNA Processing and Transcription Regulation","description":"These GO terms cluster around RNA maturation (splicing, spliceosome assembly, snRNP assembly, mRNA decay pathways) and transcription termination, pointing to RNA processing and transcription maintenance as the core theme, with a few chromatin-related terms that are less central. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006450","count":2},{"id":"GO:0008334","count":1},{"id":"GO:0009737","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0045292","count":1}]},{"hash":"457078753111089474","title":"Mitotic cell cycle progression and kinetochore localization","description":"The top GO terms are dominated by mitosis-related processes (G1/S and G2/M transitions, meiotic cell cycle, re-entry into mitotic cell cycle) and kinetochore localization, pointing to a shared function in cell division and chromosome segregation. Although a few terms, such as response to cocaine or excitatory postsynaptic potential, appear, the strongest signal centers on mitotic machinery, justifying this label.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000082","count":5},{"id":"GO:0042220","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0051321","count":4},{"id":"GO:0014044","count":4}]},{"hash":"444578113982535858","title":"Ribosome biogenesis and translation","description":"The strongest signals are ribosome biogenesis (GO:0042254) and cytoplasmic translation (GO:0002181), with tRNA modification (GO:0006400) also supporting a protein-synthesis theme. The other terms (exocytosis, phagosome maturation, TORC2 signaling, and related trafficking/immune processes) appear less central and may reflect additional regulatory roles, but the core cluster is tied to ribosome production and translation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0002181","count":4},{"id":"GO:0006400","count":3},{"id":"GO:0042832","count":3},{"id":"GO:0050885","count":3}]},{"hash":"1442717213323683603","title":"Unknown","description":"The terms are highly heterogeneous (lipid metabolism, xenobiotic processing via P450, various catabolic processes, detoxification, cold response, and cerebral cortex development) with no clear shared pathway or protein interactions, so there is no coherent theme to label the cluster. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046839","count":2},{"id":"GO:0097755","count":2},{"id":"GO:0046272","count":2},{"id":"GO:0019373","count":2},{"id":"GO:0009636","count":2}]},{"hash":"1249815678315282574","title":"Unknown","description":"The GO terms span transcription regulation, chromatin remodeling, protein ADP-ribosylation, unfolded protein response, insulin signaling, biofilm adhesion, mating type switching, and gland/uterus development, which are diverse and not clearly connected. There is no single cohesive function or pathway that ties the proteins together, so a specific, intuitive label isn't supported.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010835","count":1},{"id":"GO:0006337","count":1},{"id":"GO:0051039","count":1},{"id":"GO:0008286","count":1},{"id":"GO:0006990","count":1}]},{"hash":"1893956728789545996","title":"Unknown","description":"The GO terms across the eight proteins include heat response and temperature sensing, but also development (endothelial and epithelial differentiation), hormone secretion, chemokine production, intracellular signaling, and chloroplast protein import. This wide mix shows no single coherent biological function tying the cluster together, so a specific functional label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0050960","count":4},{"id":"GO:1903444","count":4},{"id":"GO:0030103","count":4},{"id":"GO:0060843","count":4}]},{"hash":"1265360042268139084","title":"Mitotic spindle and cytoskeleton dynamics","description":"The top GO terms cluster around mitotic spindle assembly, centrosome separation, kinetochore\u2013microtubule interactions, and actomyosin contractile ring formation, all hallmark processes of cell division and cytoskeletal organization. Additional terms like nuclear migration and chloroplast movement fit within microtubule/actin-based transport and positioning, supporting a cohesive theme of spindle- and cytoskeleton-related functions rather than a broad developmental or signaling category.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":7},{"id":"GO:1990535","count":7},{"id":"GO:0051255","count":7},{"id":"GO:0007100","count":7},{"id":"GO:0032487","count":7}]},{"hash":"170985746739432610","title":"Unknown","description":"The top terms span protein quality control (negative regulation of protein modification, ubiquitination, unfolded protein response, isomerization) as well as broad signaling and immune-related processes, including plant cytokinin signaling and animal innate defense. The mix across species and distinct biological contexts makes it unclear to assign a single cohesive function or theme to this cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031400","count":2},{"id":"GO:0046661","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0009736","count":2},{"id":"GO:0070979","count":2}]},{"hash":"200015076789423836","title":"Proteostasis and ER Stress Response","description":"The cluster includes GO terms related to unfolded protein response, protein refolding, heat shock response, and ubiquitin-mediated degradation, all core components of cellular proteostasis and stress management. A few terms touch nuclear envelope processes and nuclear transport, but the dominant theme is maintaining protein quality and responding to ER stress, making this label representative.","confidence":"Medium","size":7,"edges":11,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0000740","count":2},{"id":"GO:0090084","count":2},{"id":"GO:0009408","count":2}]},{"hash":"1336799111693356985","title":"Neural adhesion and axon guidance","description":"Based on GO terms, the cluster is enriched for neural development and cell adhesion processes: serotonergic neuron axon guidance, associative learning, and integrin-mediated cell adhesion with hemidesmosomes. The presence of hemidesmosome assembly and integrin-related adhesion suggests structural connectivity, while axon guidance and learning terms point to neuronal connectivity and function. Although there are oxidative stress and lipid metabolism signals, the neural adhesion/axon guidance theme best accounts for the combined terms.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":"wound healing","top_go_terms":[{"id":"GO:0071318","count":4},{"id":"GO:0006979","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0010888","count":3},{"id":"GO:0033631","count":3}]},{"hash":"1200391300133774276","title":"Nucleotide biosynthesis and salvage","description":"Most top GO terms cluster around nucleotide metabolism\u2014ADP biosynthesis, AMP salvage, purine ribonucleotide interconversion, CDP and ITP metabolism\u2014pointing to shared roles in nucleotide synthesis and phosphate handling. Some tissue-development terms and NK cell cytotoxicity are present but seem less central to the core function. Therefore the label reflects the predominant theme of nucleotide metabolism in this cluster.","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001889","count":3},{"id":"GO:0006172","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0046940","count":3},{"id":"GO:0046939","count":3}]},{"hash":"1445580299001189038","title":"Unknown","description":"The terms include several nuclear processes (rRNA processing, DNA replication, mitotic chromosome condensation) alongside diverse transport and metabolic processes (xenobiotic export/transmembrane transport, molybdate transport, cytochrome assembly, phytosterol absorption regulation) with no single unifying function. This lack of a coherent theme across the cluster supports labeling it Unknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0009432","count":1},{"id":"GO:0046618","count":1},{"id":"GO:0006855","count":1}]},{"hash":"99813965489581087","title":"Temperature-Responsive Signaling","description":"The top GO terms cluster around heat-related processes: response to heat and thermoception, plus brown fat differentiation linked to thermogenesis and temperature adaptation. Other terms like vasopressin secretion, endothelial differentiation, and intracellular signaling fit into broader organismal response pathways, suggesting a temperature-driven signaling theme despite some outliers (e.g., chloroplast thylakoid import). Overall, a temperature-responsive signaling label best captures the common thread among these terms.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":4},{"id":"GO:0050960","count":4},{"id":"GO:1903444","count":4},{"id":"GO:0030103","count":4},{"id":"GO:0060843","count":4}]},{"hash":"320364400480483572","title":"Neural development and axon guidance","description":"The top GO terms are dominated by neuronal development and connectivity processes: retinal ganglion cell axon guidance, commissural neuron axon guidance, corpus callosum development, fasciculation of motor neuron axon, branching morphogenesis of a nerve, dendritic spine development, and trans-synaptic signaling that modulates synaptic transmission, all pointing to neural circuit formation and synaptic maturation. An aromatic amino acid biosynthetic process term appears incidental to these neuronal functions, suggesting a secondary metabolic annotation. Overall, the cluster appears to represent neural development and axon pathfinding activities.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009073","count":2},{"id":"GO:0060021","count":1},{"id":"GO:0097156","count":1},{"id":"GO:0060996","count":1},{"id":"GO:0048170","count":1}]},{"hash":"1150012824360925937","title":"Skin-immune signaling and ECM remodeling","description":"The proteins cluster around skin epithelium functions (keratinocyte differentiation), extracellular matrix remodeling (collagen fibril organization), and immune responses (neutrophil clearance, IL-8 regulation, TH1 differentiation), with additional hints of cytoskeletal dynamics and surface signaling. This suggests a theme of coordinated epithelial-immune interactions and ECM remodeling rather than a single tight function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0032088","count":2},{"id":"GO:2000483","count":1}]},{"hash":"418431182046840455","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006747","count":1},{"id":"GO:0034628","count":1},{"id":"GO:1990966","count":1},{"id":"GO:0009611","count":1},{"id":"GO:0046444","count":1}]},{"hash":"345004139718275312","title":"Ubiquitin-Proteasome\u2013Mediated Degradation","description":"Most terms point to ubiquitination and proteasome-dependent protein catabolic processes (SCF complex\u2013dependent degradation, ubiquitin transferase activity, K6-linked ubiquitination, autoubiquitination, and ERAD/proteasomal pathways). A couple of terms touch peroxisome import and interferon signaling, but the dominant theme is ubiquitin-mediated proteolysis, supporting a label around ubiquitin\u2013proteasome\u2013driven degradation.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0060340","count":7},{"id":"GO:0071596","count":7},{"id":"GO:0051443","count":7},{"id":"GO:0033128","count":7},{"id":"GO:0085020","count":7}]},{"hash":"1346712298309609720","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0032443","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0032286","count":3}]},{"hash":"187291639944297205","title":"Unknown","description":"The GO terms are highly diverse\u2014from brain development and neuron apoptosis to cobalamin biosynthesis, chromatin assembly, transcription, translation initiation, and cell fusion\u2014showing no clear shared function. With no edges connecting the proteins, there isn\u2019t a cohesive theme to name, so Unknown with None confidence is appropriate.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0061641","count":1},{"id":"GO:0051402","count":1},{"id":"GO:0010659","count":1}]},{"hash":"1850154627044164852","title":"Retrotransposon activity and proviral latency","description":"The top terms cluster around DNA integration, transposition, and RNA-templated DNA biosynthesis, which are characteristic of retrotransposons and proviruses. Additional terms on viral entry and proviral latency reinforce a theme of mobile genetic elements interacting with host genomes and latency states. This combination points to a cohesive label focusing on retroelement activity and proviral integration/latency.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0032196","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0075732","count":1}]},{"hash":"1097668603431284417","title":"Unknown","description":"The seven proteins show highly heterogeneous GO terms (dephosphorylation, chemotaxis, bone remodeling, GPI-anchor biosynthesis, sphingomyelin catabolic process, etc.) with only single-term associations and no edges linking them. Because there is no clear common function or pathway uniting the set, a specific, representative label cannot be assigned.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":1},{"id":"GO:0046325","count":1},{"id":"GO:0006935","count":1},{"id":"GO:1903165","count":1},{"id":"GO:0046849","count":1}]},{"hash":"1149172393926659089","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010098","count":1},{"id":"GO:0002143","count":1},{"id":"GO:0032447","count":1},{"id":"GO:0002136","count":1},{"id":"GO:0031664","count":1}]},{"hash":"1863578749540622039","title":"Unknown","description":"There is no clear shared function linking these GO terms; they span antiviral/antibacterial defense and cytokine signaling as well as neural signaling and reflex/pain responses, suggesting no cohesive theme for the cluster.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":1},{"id":"GO:1903351","count":1},{"id":"GO:0050829","count":1},{"id":"GO:1904887","count":1},{"id":"GO:0045078","count":1}]},{"hash":"1286481253466286459","title":"Unknown","description":"The GO terms span diverse, unrelated processes (protein homooligomerization; wybutosine biosynthesis; renal sodium absorption; nervous system and skeletal muscle development; swimming; ubiquitin-dependent protein degradation; brassinosteroid signaling; circadian rhythm regulation; germinal center formation), indicating no single cohesive function or pathway tying these proteins together. ","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0031591","count":1},{"id":"GO:0070294","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0036268","count":1}]},{"hash":"963407937529337438","title":"Cell Cycle and Neural Development Signals","description":"The cluster\u2019s GO terms cluster around two themes: core cell-cycle processes (meiotic cell cycle, DNA replication, G1/S transition of the mitotic cell cycle, kinetochore localization) and neural development/neuronal signaling (Schwann cell development, axon regeneration, excitatory postsynaptic potential). This mix suggests the proteins may participate in both cell division machinery and neural development or maintenance, indicating a multi-functional cluster rather than a single, cohesive function.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051321","count":2},{"id":"GO:0034501","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0006260","count":2}]},{"hash":"235322475122500233","title":"Telomere regulation and differentiation signals","description":"The top GO terms separately highlight telomere maintenance/capping, while other terms point to fat cell differentiation, cell migration, and muscle stretch response, plus mRNA processing and CDK activity regulation. This mix suggests a broader growth/differentiation regulatory module with a telomere regulation component, rather than a single, cohesive pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0045444","count":2},{"id":"GO:0045736","count":2}]},{"hash":"1513857406808512309","title":"Unknown","description":"The GO terms are a mix of heat/thermoception-related processes and diverse roles (vasopressin secretion, endothelial and epithelial development, chemokine production, chloroplast import), with no single shared function across all six proteins and no reported interactions between them, making a coherent label unlikely.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":1},{"id":"GO:0050960","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0030103","count":1},{"id":"GO:0060843","count":1}]},{"hash":"119648637858121892","title":"N-terminal protein acetylation","description":"The dominant GO terms describe various N-terminal acetylation events (N-terminal methionine/protein acetylation, N-terminal serine/proline-related acetylation, and histone acetylation), pointing to a shared function in modifying protein N-termini. A few other terms (arginine/ectoine biosynthesis, angiogenesis, mitotic cohesion) appear unrelated or represent annotation noise, but do not override the clear acetylation theme.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0017196","count":6},{"id":"GO:0043967","count":6},{"id":"GO:0006526","count":6},{"id":"GO:0061606","count":6},{"id":"GO:0032920","count":6}]},{"hash":"1754116726401559795","title":"Actin Bundle Assembly and Organelle Inheritance","description":"The dominant signal is actin-related: actin filament bundle assembly is the top term, with several entries pointing to actin localization and muscle-related actin processes, alongside a few terms about mitochondrial and vacuolar inheritance. This suggests a functional theme around actin cytoskeleton organization coupled with organelle inheritance pathways, even though some terms are obsolete or peripheral.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":2},{"id":"GO:1904623","count":1},{"id":"GO:0043981","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0000001","count":1}]},{"hash":"1815252358583088320","title":"Insulin signaling and proteasome degradation","description":"The top terms show a clear link between insulin receptor signaling and proteasomal ubiquitin-dependent protein catabolic processes, implying a functional module where signaling controls protein turnover. The other terms are sparse or unrelated (e.g., nucleosome disassembly, obsolete transcription-related terms), which may reflect broad or incidental annotations. Overall, the dominant theme is coupling insulin signaling to proteasome-mediated degradation, justifying this label.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0010835","count":1},{"id":"GO:0006337","count":1},{"id":"GO:0051039","count":1}]},{"hash":"1167982538948893968","title":"Calcium Homeostasis and Ion Transport","description":"This cluster is dominated by GO terms related to intracellular calcium management (calcium homeostasis and transport to the ER) and to general ion transport, with supporting notes on dephosphorylation and energy processes. The strongest signals point to calcium signaling and ionic balance as the core theme, which can influence muscle contraction and broader signaling pathways.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046839","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0045988","count":1},{"id":"GO:0051599","count":1},{"id":"GO:0033574","count":1}]},{"hash":"1038208018846995274","title":"MAPK-linked Hormone and Stress Responses","description":"The GO terms cluster around signaling and cellular responses to a variety of stimuli (ethanol, estradiol, nutrients, oxidative stress) with an emphasis on ERK/MAPK pathway regulation, suggesting a role in hormone- and stress-responsive signaling rather than a single, narrow function. Some terms like memory and aging are less directly linked but may reflect broader cellular state contexts within signaling networks.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":1},{"id":"GO:0043086","count":1},{"id":"GO:0032355","count":1},{"id":"GO:0006813","count":1},{"id":"GO:0006979","count":1}]},{"hash":"512198516406082200","title":"Unknown","description":"The top GO terms cover heat response, temperature sensing, vascular/endothelial differentiation, hormone secretion, epithelial polarity, intracellular signaling, and even chloroplast protein import\u2014spread across plants, animals, and multicellular processes. With no edges and only a few proteins, there is no cohesive, singular function tying the cluster together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":3},{"id":"GO:0050960","count":3},{"id":"GO:1903444","count":3},{"id":"GO:0030103","count":3},{"id":"GO:0060843","count":3}]},{"hash":"2070265739374481430","title":"Calcium signaling and secretion regulation","description":"The GO terms cluster around calcium ion transport and regulation of calcium release channels (presynaptic calcium concentration and ryanodine receptor activity), which ties to calcium-triggered secretion (e.g., insulin release). A few terms relate to muscle development and cytoskeletal transport, but the common thread is calcium signaling and controlled exocytosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035774","count":1},{"id":"GO:0051281","count":1},{"id":"GO:0035502","count":1},{"id":"GO:0019749","count":1},{"id":"GO:0055003","count":1}]},{"hash":"1707185124214775867","title":"Unknown","description":"The terms span development (prostate gland, fat pad, male differentiation), immune defense (innate response, defense against virus), photoreceptor localization, ER-stress\u2013related translation regulation, and ubiquitination, with no clear shared function. This cluster lacks a cohesive biological theme, so a single descriptive label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030850","count":2},{"id":"GO:1903546","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0031400","count":1},{"id":"GO:0046661","count":1}]},{"hash":"2269150935850748032","title":"ER-Golgi trafficking and ER stress signaling","description":"The top terms emphasize vesicle transport between the endoplasmic reticulum and Golgi, including retrograde transport, alongside the intrinsic apoptotic pathway activated by ER stress, pointing to a shared role in ER quality control and stress signaling. Development-related terms are present but seem less cohesive with the trafficking/apoptosis theme, so the core function is ER trafficking and ER stress response.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0070262","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006351","count":2}]},{"hash":"288595788032114040","title":"Unknown","description":"The top terms are a mix of heat response, temperature sensing, fat and endocrine processes, vascular differentiation, general cell signaling, chemokine production, epithelial polarity, and even plant chloroplast protein import. This scattered combination does not suggest a single cohesive function or pathway for the cluster, so a generic Unknown label with no confident representation is appropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":1},{"id":"GO:0050960","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0030103","count":1},{"id":"GO:0060843","count":1}]},{"hash":"250708095581265040","title":"Unknown","description":"The terms span ribophagy, ubiquitin recycling, CENP-A chromatin assembly, various apoptotic processes, growth hormone response, meiotic nuclear division, translation preinitiation complex formation, DNA-templated transcription, and cellular fusion. With no edges and little thematic overlap, there is no clear shared function tying these proteins together to justify a more specific label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034517","count":1},{"id":"GO:0010992","count":1},{"id":"GO:0061641","count":1},{"id":"GO:0051402","count":1},{"id":"GO:0010659","count":1}]},{"hash":"344179988521796654","title":"Secretory trafficking and actin dynamics","description":"This cluster combines ER-to-Golgi vesicle transport and COPII regulation with multiple actin cytoskeleton regulators (actin nucleation, filament capping, podosome assembly), suggesting a coordinated module for vesicle trafficking coupled to cytoskeletal remodeling. The presence of ER organization and lumen-related terms further supports a secretory pathway\u2013cytoskeleton nexus.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003400","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0080119","count":1},{"id":"GO:0071801","count":1},{"id":"GO:0032532","count":1}]},{"hash":"1283868354561522984","title":"Cell Cycle Regulation with Heat and Endocrine Signaling","description":"Dominant terms are cell cycle and regulation of cell cycle (2 and 1 proteins), pointing to core cell cycle control. Other terms (heat response, thermoception, vasopressin secretion, chemokine production, endothelial differentiation) suggest related signaling and physiological contexts, but they appear secondary to the central cell cycle theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0009408","count":1},{"id":"GO:0050960","count":1},{"id":"GO:1903444","count":1},{"id":"GO:0071157","count":1}]},{"hash":"1979993878639255040","title":"Heat Response Signaling","description":"Based on GO terms, the cluster is enriched for heat-related terms: GO:0009408 response to heat and GO:0050960 detection of temperature stimulus involved in thermoception, indicating a focus on how cells detect and respond to heat. Additional terms such as intracellular signal transduction and multicellular organismal process suggest downstream signaling in a multicellular context. While other terms like vasopressin secretion and endothelial differentiation are broader, the dominant theme is temperature sensing and heat-induced signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0030103","count":2},{"id":"GO:0060843","count":2}]},{"hash":"1785292469490913772","title":"Unknown","description":"This cluster shows a mix of diverse and sometimes obsolete GO terms (DNA repair/meiotic recombination, telomere shelterin, plant signaling, seed growth, viral processes, histone modification) with no clear shared function or pathway connecting all proteins, so a coherent, specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010520","count":1},{"id":"GO:0070933","count":1},{"id":"GO:0009736","count":1},{"id":"GO:0035522","count":1},{"id":"GO:0016032","count":1}]},{"hash":"1329957539261243969","title":"Gene Expression and Protein Turnover","description":"The cluster centers on core gene expression and protein maintenance processes: ribosome biogenesis, formation of the translation preinitiation complex, and DNA-templated transcription, with chromatin assembly and proteasomal degradation also represented. Although there are some context-specific terms (apoptosis in neuron and heart), the dominant signals point to fundamental cellular expression and protein turnover mechanisms that tie these proteins together.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0061641","count":1},{"id":"GO:0051402","count":1},{"id":"GO:0010659","count":1},{"id":"GO:0060416","count":1}]},{"hash":"908768533040313888","title":"Ciliary and Flagellar Motility and Axoneme Assembly","description":"The proteins cluster around functions related to cilia and flagella, including cilium movement, axoneme assembly, and flagellated sperm motility, with links to left/right symmetry determination and brain development, all of which point to microtubule-based motility and ciliary structure.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003351","count":1},{"id":"GO:0007368","count":1},{"id":"GO:1904526","count":1},{"id":"GO:0007420","count":1},{"id":"GO:0030317","count":1}]},{"hash":"1622115189548898004","title":"Terpenoid and Isoprenoid Biosynthesis","description":"This cluster centers on biosynthetic processes for terpenoids and isoprenoids (farnesyl, geranyl, and geranylgeranyl diphosphate; monoterpene; cholesterol; quinone biosynthesis), indicating a cohesive role in assembling isoprenoid lipids and related molecules; the other terms are less central but may reflect ancillary associations.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":1},{"id":"GO:0033386","count":1},{"id":"GO:1901663","count":1},{"id":"GO:0043693","count":1},{"id":"GO:0045337","count":1}]},{"hash":"154010789128522794","title":"Nuclear transport of ribosomal and RNA-binding proteins","description":"The top GO terms repeatedly point to import into the nucleus (snRNP, hnRNP, transcription factors, ribosomal proteins) and export of ribosomal subunits, indicating a shared function in nuclear transport of RNA-processing and ribosome\u2013assembly components. Minor associated terms (desumoylation regulation, transcription regulation) support a broader nuclear RNA-processing theme, despite some obsolete annotations.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006608","count":1},{"id":"GO:0042991","count":1},{"id":"GO:0060188","count":1},{"id":"GO:0000056","count":1},{"id":"GO:0035735","count":1}]},{"hash":"848801809999225418","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0009089","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0042823","count":2}]},{"hash":"1220832507730307589","title":"Endosomal trafficking and secretory pathway","description":"The four proteins share GO terms centered on endosomal and secretory trafficking, including phagosome maturation, multivesicular body sorting, and the regulated secretory pathway. While other terms touch on differentiation processes (keratinocyte development, osteoblast proliferation), the dominant functional theme across the cluster is vesicle trafficking and sorting, with some signaling context (regulation of protein kinase activity). Hence an endosomal/secretory trafficking label best captures the common function.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090382","count":4},{"id":"GO:0003334","count":4},{"id":"GO:0045859","count":4},{"id":"GO:1903307","count":4},{"id":"GO:1902570","count":4}]},{"hash":"1927859303845955552","title":"Mitotic spindle assembly and cytokinesis","description":"This cluster\u2019s top GO terms are dominated by mitosis-related processes: spindle midzone assembly, centrosome separation, spindle pole body separation, and kinetochore-associated microtubule dynamics, plus actomyosin contractile ring assembly for cytokinesis. While a few terms (root development, neuron projection maintenance) are more general or outliers, the strongest and most frequent signals point to cell division machinery, specifically spindle organization and cytokinesis.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":1},{"id":"GO:1990535","count":1},{"id":"GO:0051255","count":1},{"id":"GO:0007100","count":1},{"id":"GO:0032487","count":1}]},{"hash":"795966966127450801","title":"Kinase Signaling and Proliferation Regulation","description":"The GO terms point to regulation of kinase activity (autophosphorylation, serine/threonine kinases), along with regulators of GTPase and guanylate cyclase activities, and processes tied to cell growth (mitotic cell cycle, proliferation) and metabolic signaling (hypoxia response, insulin secretion). This suggests a cluster of proteins that modulate signaling pathways through phosphorylation and second messengers, influencing proliferation and metabolic responses.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031954","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0071902","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1766143980842725721","title":"Signaling Regulation and Calcium Transport","description":"The top GO terms cluster around regulation of signaling activities (GTPase and guanylate cyclase) and calcium handling (calcium transport and import), plus modulation of insulin secretion in response to glucose. While a few terms are less coherent (digestion, lipid remodeling), the predominant theme is modulation of cellular signaling and calcium dynamics, so the label reflects this general function of the protein set.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0090151","count":1},{"id":"GO:0007586","count":1},{"id":"GO:0031284","count":1},{"id":"GO:0035774","count":1}]},{"hash":"313994069951170765","title":"Reactive Oxygen Species Detoxification","description":"The top GO terms point to removal of superoxide radicals and response to toxic substances, reflecting oxidative stress management and redox activity. Despite the obsolete term, the cluster appears to group proteins involved in detoxifying reactive oxygen species and responding to oxidative stress.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019430","count":1},{"id":"GO:0009636","count":1},{"id":"GO:0055114","count":1}]},{"hash":"487060839122499606","title":"Heat Response and Thermoregulation","description":"The top GO terms cluster around heat and temperature sensing (response to heat, detection of temperature stimulus) and thermogenesis-related regulation (e.g., brown fat differentiation), suggesting a shared function in responding to thermal stress and maintaining temperature homeostasis. The other terms point to broader cellular signaling and tissue processes but do not overshadow the thermal theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0030103","count":2},{"id":"GO:0060843","count":2}]},{"hash":"319440410950015319","title":"Spliceosome Assembly and RNA Splicing","description":"The strongest GO signals are about spliceosome assembly and mRNA splicing (spliceosomal complex/snRNP assembly, mRNA splicing via spliceosome, and related terms). Additional RNA-processing terms (rRNA maturation, histone mRNA metabolism, mRNA decay) suggest a broader nuclear RNA-processing role, but the central theme appears to be spliceosome-driven RNA maturation. ABA response and heterochromatin-related terms are secondary contextual associations rather than core functions.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":3},{"id":"GO:0008334","count":2},{"id":"GO:0009737","count":2},{"id":"GO:0000245","count":2},{"id":"GO:0045292","count":2}]},{"hash":"341654961997773927","title":"Meiotic DNA Repair and Recombination","description":"The terms cluster around meiotic double-strand break repair and recombination, including DSBR in meiosis, synaptonemal complex assembly, and joint molecule formation, plus replication-associated repair and the SOS response; together they point to meiosis-specific DNA repair and recombination mechanisms.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1990918","count":2},{"id":"GO:0009432","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0006260","count":2},{"id":"GO:1990426","count":2}]},{"hash":"880852197813152304","title":"Thermal Response and GPCR Signaling","description":"This cluster centers on responses to heat and detection of temperature, with supporting entries for GPCR-related signaling and intracellular signal transduction. The presence of terms like response to heat and detection of temperature stimulus suggests a thermosensory signaling theme, while kinases and GPCR pathway terms hint at the signaling mechanics. Other terms reflect metabolic and endocrine connections but do not overwhelm the core thermosensory signal. Given the small cluster and mixed signals, the label is plausible but not definitive.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0006469","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2}]},{"hash":"1465196346200720078","title":"Unknown","description":"Top terms are highly diverse (GTPase regulation, mechanical response, chromatin assembly, apoptosis, growth hormone response, translation initiation, transcription, meiotic division, cellular fusion) with no clear unifying function or connectivity, so a meaningful label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0061641","count":1},{"id":"GO:0051402","count":1},{"id":"GO:0010659","count":1}]},{"hash":"1006066373867068917","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905267","count":1},{"id":"GO:0000294","count":1},{"id":"GO:0016078","count":1},{"id":"GO:0034965","count":1},{"id":"GO:0001682","count":1}]},{"hash":"2008189258508704515","title":"Heat Response and Temperature Signaling","description":"This cluster centers on genes involved in responding to heat and detecting temperature changes (therm perception), pointing to thermoregulation and temperature-triggered signaling across tissues. Additional terms like brown fat differentiation, vasopressin secretion, and epithelial polarity suggest downstream systemic regulation and multicellular coordination in response to thermal stress, even though some annotations (e.g., chloroplast-related) may reflect dataset noise. Overall, the shared theme is temperature-driven signaling in organisms.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":2},{"id":"GO:0050960","count":2},{"id":"GO:1903444","count":2},{"id":"GO:0030103","count":2},{"id":"GO:0060843","count":2}]},{"hash":"1325550569750447399","title":"Unknown","description":"Top terms span immune signaling, neural development, growth factor signaling, hormone signaling, and DNA repair; there is no single cohesive function linking these proteins, so a specific label cannot be assigned.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":4},{"id":"GO:0038093","count":4},{"id":"GO:0006281","count":4},{"id":"GO:0090169","count":4},{"id":"GO:0038109","count":4}]},{"hash":"748823482648050947","title":"Plant meiosis and gametophyte development","description":"The Top Terms include double-strand break repair and reciprocal meiotic recombination, together with embryo sac development and pollen development, pointing to meiotic processes and male/female gametophyte formation in plants. This combines both meiotic DNA repair and reproductive development into a cohesive theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006302","count":1},{"id":"GO:0009553","count":1},{"id":"GO:0007131","count":1},{"id":"GO:0009555","count":1}]},{"hash":"1710827121884377428","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning translation, stress responses (cycloheximide and antibiotics), P granule assembly, chromosome localization and segregation, septin dynamics, and signal transduction. With no evident shared function or direct interactions among the four proteins, there is no cohesive theme to label the cluster, so Unknown with None confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046898","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0090219","count":1},{"id":"GO:1903863","count":1}]},{"hash":"57543602424571552","title":"Unknown","description":"The terms span immune signaling (Fc receptor, IL-1), heat/temperature response, DNA repair, spindle assembly, and neural processes (axon fasciculation, chemotaxis); there is no single cohesive function linking all four proteins.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060258","count":1},{"id":"GO:0038093","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0090169","count":1}]},{"hash":"1859079350180796249","title":"Neural development and cell adhesion","description":"This cluster features terms tied to nervous system processes (peripheral nervous system axon regeneration, associative learning) alongside adhesion-related processes (integrin-mediated cell adhesion, hemidesmosome assembly, substrate adhesion-dependent spreading). The combination suggests proteins that coordinate neuronal development/remodeling with cell\u2013matrix adhesion, potentially linked to membrane lipid context (ganglioside metabolism). Overall, a cohesive theme of neural development linked to adhesion, with some lipid-associated hints.","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010888","count":1},{"id":"GO:0033631","count":1},{"id":"GO:0031581","count":1},{"id":"GO:0032369","count":1},{"id":"GO:0008306","count":1}]},{"hash":"687920856105226580","title":"Amino acid and antibiotic biosynthesis","description":"The top GO terms show amino acid biosynthesis (glutamine, asparagine) and specific antibiotic biosynthesis (clavulanic acid and general antibiotic biosynthesis), suggesting the proteins cluster around biosynthetic metabolism. Supporting terms about lipid catabolism and xenobiotic transport hint at broader metabolic roles, but the primary signal is biosynthesis of amino acids and antibiotics.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":1},{"id":"GO:0033050","count":1},{"id":"GO:0070981","count":1},{"id":"GO:0017000","count":1},{"id":"GO:0043617","count":1}]},{"hash":"1873126605988219820","title":"Vacuolar amino acid transport","description":"The top GO terms are dominated by transmembrane transport of amino acids into the vacuole (and one export term), including arginine, lysine, histidine, proline, alanine, and glutamine. This strongly suggests a function as vacuolar amino acid transporters, with a common theme of amino acid movement across the vacuolar membrane. A lithium ion transport term appears but does not override the amino-acid/vacuolar transport signal; one term about root cap development seems unrelated noise. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090518","count":1},{"id":"GO:1990818","count":1},{"id":"GO:0090452","count":1},{"id":"GO:0090517","count":1},{"id":"GO:0061402","count":1}]},{"hash":"1955467455028245214","title":"Unknown","description":"Top GO terms span immune signaling (Fc receptor, IL-1), neuronal development (cerebellum development, axon fasciculation), KIT and peptide hormone signaling, chemotaxis, and DNA repair, with no single cohesive function connecting all four proteins. This diversity suggests multifunctional roles or heterogeneous annotations rather than a common pathway, so a specific label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":3},{"id":"GO:0038093","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0090169","count":3},{"id":"GO:0038109","count":3}]},{"hash":"1147843130010331527","title":"Unknown","description":"This cluster contains four proteins but has no edges, no triangles, and no GO terms assigned in the data, so there is no clear shared function or process to characterize. Without functional terms or interactions, a meaningful label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"666850279109757247","title":"Unknown","description":"There are no GO terms or interaction data linking these four proteins, so there is no clear shared function to name. Without a common theme, a meaningful label cannot be assigned; the only available note is that one protein was re-added by ReCIPE with a degree of 0.75, but that does not define a function for the cluster.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1371636392341912876","title":"Unknown","description":"The four proteins are associated with a wide and diverse set of GO terms (immune signaling, DNA repair, heat response, spindle/neuronal processes, chemotaxis, temperature sensing) with no clear, single shared function or pathway, making a coherent label difficult.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":3},{"id":"GO:0038093","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0090169","count":3}]},{"hash":"1488065074316176241","title":"Mitotic spindle organization and cytokinesis","description":"Based on the dominant set of GO terms relating to mitotic spindle assembly, centrosome separation, spindle pole dynamics, kinetochore-microtubule attachments, and actomyosin-based cytokinesis, this cluster appears to group proteins involved in cell division and spindle machinery. Some terms like root development or chloroplast movement are present but seem peripheral; the core signal points to mitosis/cytoskeleton functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":3},{"id":"GO:1990535","count":3},{"id":"GO:0051255","count":3},{"id":"GO:0007100","count":3},{"id":"GO:0032487","count":3}]},{"hash":"479091102814085833","title":"Heat Shock Response and Inflammation","description":"Based on the top GO terms, the cluster centers on a heat stress response with protein refolding and concurrent upregulation of inflammatory signaling (IL-6 production, inflammatory response, immune cell activity). While a few terms seem unrelated (telomerase RNA localization to Cajal bodies, sperm-zona pellucida binding), the predominant themes point to a stress-tolerance and immune-modulatory module.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009408","count":3},{"id":"GO:2000778","count":3},{"id":"GO:1904874","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0042026","count":3}]},{"hash":"1954478153774459573","title":"Calcium signaling and exocytosis regulation","description":"The top GO terms are dominated by calcium handling and exocytosis, including calcium ion transport, cellular response to calcium, and positive regulation of exocytosis, plus regulatory actions on calcium-release channels. This points to a theme of calcium-dependent signaling coordinating secretory processes (e.g., insulin secretion in response to glucose), hence a concise label around calcium signaling and exocytosis regulation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031284","count":1},{"id":"GO:0035774","count":1},{"id":"GO:0090281","count":1},{"id":"GO:0070588","count":1},{"id":"GO:0006816","count":1}]},{"hash":"2066077610127859574","title":"Fungal cell wall synthesis and mating","description":"This cluster shows strong representation of fungal-specific processes:GO:0070880 fungal-type cell wall beta-glucan biosynthetic process and GO:0000742 karyogamy involved in conjugation with cellular fusion, which point to fungal development and cell wall construction during mating. Additional terms like cell morphogenesis and unfolded protein response reflect cellular remodeling and stress handling in fungi. While some terms (DNA replication, SRP-dependent targeting) are universal, the fungal-centric terms dominate, justifying a label focused on fungal cell wall synthesis and mating.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":3},{"id":"GO:0070880","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0090084","count":2},{"id":"GO:0070389","count":2}]},{"hash":"1726705184954271192","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0009432","count":3},{"id":"GO:0006269","count":3},{"id":"GO:0006311","count":3},{"id":"GO:0000467","count":3}]},{"hash":"124611499376730085","title":"Unknown","description":"The top GO terms are highly heterogeneous with no shared function across the proteins: DNA repair, cell cycle/mitosis processes, neural development, exocytosis, chemotaxis, translation regulation, and dopamine response. With no reported interactions (edges/triangles) and only a scattered set of one-off terms, there isn\u2019t a coherent functional theme to unify the cluster. Therefore, the appropriate label is Unknown with no confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060258","count":1},{"id":"GO:0000751","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0021695","count":1},{"id":"GO:0090169","count":1}]},{"hash":"721842999262343403","title":"Vertebrate Developmental Gene Expression","description":"The top GO terms point to vertebrate development (multicellular organism development, skeletal system development, neural tube closure) and DNA-templated transcription, suggesting these proteins regulate gene expression during development. Additional terms for ER-stress\u2013related apoptosis and cadmium response imply linked stress-response roles, with ribosome biogenesis and general defense processes providing supporting cellular machinery. Overall, the cluster seems to group transcriptional regulation during development with associated stress-response pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0070059","count":2},{"id":"GO:0007275","count":2}]},{"hash":"981007045119116468","title":"Meiotic recombination and immunoglobulin diversification","description":"This cluster shows strong signals for DNA recombination and repair in meiosis (meiotic gene conversion, mismatch repair in recombination, double-strand break repair, germ cell development, gene conversion at mating-type locus) and also immune-related diversification (somatic hypermutation of immunoglobulin genes, isotype switching to IgA). Together, these terms point to a cluster of proteins involved in both meiotic recombination and antibody gene diversification, though the immune terms broaden the context beyond strictly meiosis. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006311","count":1},{"id":"GO:0010777","count":1},{"id":"GO:0048298","count":1},{"id":"GO:0007281","count":1},{"id":"GO:0007534","count":1}]},{"hash":"1413467140899264127","title":"Plant cell wall polysaccharide biosynthesis","description":"This cluster centers on carbohydrate metabolism and cell wall biosynthesis in plants, as indicated by GO terms for callose deposition and multiple UDP-sugar\u2013mediated biosynthetic pathways (UDP-galactose, UDP-L-arabinose, UDP-alpha-D-glucose) as well as glucan and glycogen-related processes, suggesting a theme of building and remodeling plant cell wall polysaccharides.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0052543","count":1},{"id":"GO:0052573","count":1},{"id":"GO:0046506","count":1},{"id":"GO:0016036","count":1},{"id":"GO:0033356","count":1}]},{"hash":"19572381233353614","title":"Unknown","description":"This cluster includes antiviral/innate immune terms (defense response to virus, innate immune response, positive regulation of interferon-beta production) alongside transcription by RNA polymerase III and several unrelated processes (CENP-A chromatin assembly, apoptosis in neurons and cardiac muscle, growth hormone response, meiotic division). The varied functions do not point to a single cohesive role for all members, so a specific, representative label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032728","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0051607","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0006359","count":1}]},{"hash":"1563540774541255979","title":"Membrane Transport of Xenobiotics and Metabolites","description":"This cluster is dominated by GO terms for membrane transport of various substrates, including xenobiotics, molybdate ions, cGMP, cutin, and phytosterols. While there are a few terms related to stress response or development, the strongest common thread across the terms is transmembrane transport, suggesting the proteins function in moving diverse molecules across membranes. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009432","count":1},{"id":"GO:0046618","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015689","count":1},{"id":"GO:0080051","count":1}]},{"hash":"826914403366243448","title":"Proteostasis and immune signaling regulators","description":"The cluster centers on protein quality control and folding (protein folding, chaperone-mediated assembly, regulation of proteasomal degradation) suggesting a role in proteostasis; it also includes terms linked to immune/stress signaling (complement regulation, interferon signaling), implying these proteins may regulate both proteostasis and immune response pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903660","count":1},{"id":"GO:0071157","count":1},{"id":"GO:0071318","count":1},{"id":"GO:0030511","count":1},{"id":"GO:0009651","count":1}]},{"hash":"798211476904437005","title":"Membrane Transporters for Xenobiotics and Nutrients","description":"The Top Terms are dominated by various membrane transport functions (xenobiotic, vitamin, carbohydrate, molybdate, lipoprotein) indicating a set of transporter proteins handling diverse substrates across membranes; a few terms (SOS response, stem cell proliferation, cytochrome complex assembly) are less aligned with this theme, but overall the transport-focused terms prevail.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009432","count":1},{"id":"GO:0046618","count":1},{"id":"GO:0006855","count":1},{"id":"GO:0015689","count":1},{"id":"GO:0072089","count":1}]},{"hash":"755288295255667927","title":"Detox and natural product metabolism","description":"This cluster\u2019s GO terms cluster around processing and responding to natural products and xenobiotics, including biosynthesis of secondary metabolites (strigolactone, alkaloids, antibiotics) and degradation/catabolism pathways (beta-ketoadipate, glucuronoside), as well as a general response to toxic substances. The combination points to a shared theme of detoxification and secondary metabolism rather than a single narrowly defined function, hence a broad label like this is appropriate. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":2},{"id":"GO:0046839","count":1},{"id":"GO:1990577","count":1},{"id":"GO:1901601","count":1},{"id":"GO:0042952","count":1}]},{"hash":"1748483996363661461","title":"Mitochondrial tRNA Synthetases","description":"The cluster centers on mitochondrial tRNA aminoacylation (tryptophanyl, valyl, tyrosyl) and translation, suggesting the proteins are mitochondrial aminoacyl-tRNA synthetases driving mitochondrial protein synthesis; the vascular terms are likely incidental noise. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070183","count":1},{"id":"GO:0006438","count":1},{"id":"GO:0070184","count":1},{"id":"GO:0001570","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1245635147470485870","title":"Ion Transport and Membrane Homeostasis","description":"The top GO terms cluster around ion transport across membranes (sodium, proton), vacuolar acidification, and ion homeostasis, with supporting terms on cell volume regulation; one outlier (BDNF receptor signaling) seems incidental. Overall, the proteins appear linked to membrane ion transport and homeostasis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":2},{"id":"GO:0036376","count":1},{"id":"GO:0031547","count":1},{"id":"GO:0006884","count":1},{"id":"GO:1902600","count":1}]},{"hash":"2033403105849444745","title":"DNA Transcription Regulation and Oxidative Stress","description":"The top GO terms point to transcriptional regulation (DNA-templated transcription, negative regulation of transcription by RNA polymerase II, positive regulation of DNA binding) and cellular responses to oxidative stress/redox homeostasis. This suggests a broad link between gene regulation and stress response, though several terms are obscure or peripheral (including some obsolete terms), and the small cluster size limits a confident, narrow assignment. Overall, the label reflects the most coherent theme across terms.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006662","count":1},{"id":"GO:0018401","count":1},{"id":"GO:0043388","count":1},{"id":"GO:0030091","count":1},{"id":"GO:1903206","count":1}]},{"hash":"2255253916646852778","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990180","count":1},{"id":"GO:0001680","count":1},{"id":"GO:0042245","count":1},{"id":"GO:0006378","count":1}]},{"hash":"1735161865822714799","title":"Unknown","description":"The top GO terms are highly diverse, spanning insulin secretion, symbiont entry, integrin-mediated adhesion, T cell activation, extracellular matrix regulation, cellulose catabolism, neural behavior, melanocyte proliferation, endothelial migration, and contact inhibition\u2014groups with little cohesive functional meaning across just three proteins. With no edges and such heterogeneity, there is no clear shared biology to label a specific cluster function. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050796","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0033632","count":1},{"id":"GO:0042110","count":1},{"id":"GO:0010716","count":1}]},{"hash":"1852329536157049511","title":"Unknown","description":"The top GO terms are highly heterogeneous, covering immune signaling, neural development, temperature response, DNA repair, and more, with no clear common function or pathway tying the proteins together. There are no edges or clusters to support a cohesive biological theme, so a specific label cannot be inferred.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060258","count":2},{"id":"GO:0038093","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0009408","count":2},{"id":"GO:0090169","count":2}]},{"hash":"6611103572864605","title":"Golgi-endosome-vacuole protein trafficking","description":"The GO terms indicate vesicle and protein transport within the endomembrane system, notably Golgi to vacuole transport, endocytic recycling, and retrograde transport from endosome to Golgi.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006896","count":1},{"id":"GO:1990126","count":1},{"id":"GO:0042147","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0009245","count":1}]},{"hash":"1408560535228547346","title":"Nucleotide catabolism and salvage","description":"The GO terms are dominated by nucleotide catabolic processes (guanosine, uridine, inosine, urate) and salvage pathways (UMP salvage, nicotinamide riboside/NAD salvage), indicating these proteins are likely involved in nucleotide turnover and salvage pathways rather than a single specific function. This cohesive theme supports a label of nucleotide catabolism and salvage for the cluster, despite the small size and limited interactions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046115","count":1},{"id":"GO:0006218","count":1},{"id":"GO:0009166","count":1},{"id":"GO:0034356","count":1},{"id":"GO:0034418","count":1}]}]