{"hash":"1866249441557538897","title":"Ubiquitin-ERAD proteostasis and aggrephagy","description":"The cluster is dominated by ubiquitin-related processes (deubiquitination, sumoylation, autoubiquitination) and ERAD pathways, plus an autophagy angle (aggrephagy) for clear protein quality-control function. Together these terms point to a module coordinating ubiquitin signaling, ER-associated degradation, and selective autophagic clearance of misfolded proteins, hence the label. Some terms are obsolete, but the core theme remains proteostasis via ubiquitin/SUMO modification and ERAD- and aggrephagy-related processes.","confidence":"High","size":22,"edges":226,"triangles":1442,"max_degree":21,"top_function":null,"members":[{"accession":"XP_024380927.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_024363104.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"XP_024369015.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"XP_024379810.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_024399890.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0007023","GO:0031117","GO:0014889","GO:0031122","GO:0048936"]},{"accession":"XP_024363411.1","go_terms":["GO:0045190","GO:0009688","GO:0044810","GO:0090282","GO:0090419","GO:0009190","GO:0033624","GO:0021693","GO:1903468","GO:0034244","GO:1990705","GO:0032487","GO:0051237","GO:0070535","GO:0035196","GO:0072383","GO:0007249","GO:0090055","GO:0021685","GO:1905150"]},{"accession":"XP_024390718.1","go_terms":["GO:0046902","GO:0070940","GO:0030150","GO:1903740","GO:2000134","GO:0010867","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"XP_024370637.1","go_terms":["GO:0032020","GO:0034126","GO:0021766","GO:0021764","GO:0016925","GO:0060996","GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0002143","GO:0032447","GO:0045116","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0045892","GO:0061504","GO:0007113","GO:0000422","GO:0051726","GO:0016567"]},{"accession":"XP_024392167.1","go_terms":["GO:0032020","GO:0034126","GO:0021766","GO:0021764","GO:0016925","GO:0060996","GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0002143","GO:0032447","GO:0045116","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0045892","GO:0061504","GO:0007113","GO:0000422","GO:0051726","GO:0016567"]},{"accession":"XP_024394045.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"XP_024359974.1","go_terms":["GO:0007113","GO:0045116","GO:0051726","GO:0038061","GO:0045892","GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0021764","GO:0002143","GO:0032447","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0061504","GO:0016925","GO:0000422"]},{"accession":"XP_024398305.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","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