{"hash":"601565921240543938","title":"Macrophage lipid remodeling and foam cell formation","description":"These proteins appear to participate in lipid remodeling and lipid biosynthesis/catabolism (LDL particle remodeling; phosphatidic acid, phosphatidylcholine, and phosphatidylglycerol acyl-chain remodeling) together with innate immune functions, including regulation of macrophage activation and foam cell differentiation, and leukotriene synthesis with ERK signaling. This suggests a theme of macrophage lipid metabolism linked to innate immune responses and inflammatory signaling.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"members":[{"accession":"XP_030843287.1","go_terms":[]},{"accession":"XP_030837293.1","go_terms":[]},{"accession":"XP_030839075.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"XP_030839079.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"XP_001197510.2","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"XP_001197473.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]}],"graph":[["XP_001197473.1","XP_001197510.2",0.528],["XP_001197473.1","XP_030839075.1",0.576],["XP_001197473.1","XP_030839079.1",0.596],["XP_030837293.1","XP_030839075.1",0.557],["XP_030837293.1","XP_030839079.1",0.674],["XP_001197510.2","XP_030839075.1",0.556],["XP_001197510.2","XP_030839079.1",0.537],["XP_030843287.1","XP_030839075.1",0.571],["XP_030843287.1","XP_030839079.1",0.64],["XP_030839075.1","XP_030839079.1",0.584]],"all_go_terms":{"GO:0034374":4,"GO:0019370":4,"GO:0044240":4,"GO:0070374":4,"GO:0002227":4,"GO:0036148":4,"GO:0043030":4,"GO:0006654":4,"GO:0010744":4,"GO:0036151":4,"GO:0036150":4,"GO:0050482":4,"GO:0090238":4,"GO:0050830":4,"GO:0010884":4,"GO:0019731":4,"GO:0010518":4,"GO:0032637":4,"GO:0042130":4,"GO:0002446":4,"GO:0036152":4,"GO:0002361":4,"GO:0032308":4,"GO:0051977":4,"GO:0036149":4,"GO:0090370":4,"GO:0032612":4,"GO:0045740":4},"recipe_readded":[]}