{"hash":"257589080300292623","title":"Protein homeostasis and sphingolipid metabolism","description":"The cluster emphasizes protein turnover and quality control, with GO terms for translation initiation regulation, preinitiation complex formation, COP9 signalosome assembly, deneddylation, and proteasome-mediated degradation, suggesting coordinated control of protein synthesis and degradation. It also includes ceramide transport and glycosphingolipid metabolism, indicating sphingolipid trafficking/metabolism, and a salicylic acid response hinting at stress signaling. Together these themes point to a combined role in maintaining proteome and membrane lipid homeostasis under stress.","confidence":"Medium","size":23,"edges":127,"triangles":303,"max_degree":21,"top_function":null,"members":[{"accession":"XP_030844831.1","go_terms":[]},{"accession":"XP_030855331.1","go_terms":["GO:0007250","GO:0000338","GO:0043161","GO:0006446","GO:0060625","GO:1903955","GO:0010387","GO:0043248","GO:0001731"]},{"accession":"XP_030830150.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"XP_030832266.1","go_terms":[]},{"accession":"XP_030832311.1","go_terms":[]},{"accession":"XP_030850115.1","go_terms":["GO:0090305","GO:0006313"]},{"accession":"XP_784137.3","go_terms":["GO:0035621","GO:0009751","GO:0009816","GO:0072488","GO:0046836","GO:0015695","GO:0006687","GO:1902389","GO:0015791"]},{"accession":"XP_003729809.2","go_terms":["GO:0070230","GO:0070236","GO:0048262","GO:0002268","GO:0050728","GO:1905206","GO:0048297","GO:0098907","GO:0051798","GO:0071316","GO:0043123","GO:0060545","GO:0060546","GO:0009682","GO:0048536","GO:0046330","GO:0071285","GO:0036371","GO:0031663","GO:0002377","GO:0071447","GO:0010881","GO:0045651","GO:1903140","GO:2000630","GO:0006925","GO:0006924","GO:0071260","GO:0003283","GO:1902895","GO:0036462","GO:1902622","GO:0032494","GO:0090557","GO:0046784","GO:0044130","GO:0035994","GO:0007432","GO:0071359","GO:0071354","GO:2000310","GO:0098910","GO:0032760","GO:2000002","GO:0042489","GO:0051092","GO:2000338","GO:0006954","GO:0002755","GO:0031642","GO:0032088","GO:0006693","GO:1902042","GO:1902043","GO:0048148","GO:0072661","GO:0072660","GO:0030889","GO:0036289","GO:0086005","GO:0016064","GO:0033564","GO:2000663","GO:2000666","GO:0001783","GO:2001241","GO:0032675","GO:2001180","GO:0032747","GO:0032740","GO:0010936","GO:0034122","GO:0006977","GO:0021859","GO:0061057","GO:0086014","GO:0045351","GO:0002467","GO:0045060","GO:0038061","GO:0007249","GO:2001240","GO:0097527","GO:1900127","GO:0097252","GO:0002238","GO:2000341","GO:0060340","GO:0097192","GO:0070498","GO:0032496","GO:0097202","GO:0097049","GO:0042511","GO:0010467","GO:1901026","GO:0071550","GO:1903588","GO:0032464","GO:0097284","GO:0006919","GO:0010933","GO:0045080","GO:0045083","GO:0070926","GO:1990000","GO:0086070","GO:0010956","GO:0071356","GO:0097296","GO:0032757","GO:0070555","GO:2000454"]},{"accession":"XP_030839580.1","go_terms":[]},{"accession":"XP_030855981.1","go_terms":["GO:1905606","GO:0030307","GO:2000507","GO:0031053","GO:0000184","GO:0010801","GO:0048026","GO:1905696","GO:1900363","GO:0048820","GO:0030422","GO:0098789","GO:0006406","GO:1905612","GO:0048574","GO:0006446","GO:1905618","GO:0031047","GO:0048136","GO:0031442","GO:0045292","GO:1905537","GO:0006370","GO:0008315"]},{"accession":"XP_003726650.1","go_terms":[]},{"accession":"XP_030854167.1","go_terms":[]},{"accession":"XP_798633.1","go_terms":["GO:0035621","GO:0009751","GO:0009816","GO:0072488","GO:0046836","GO:0015695","GO:0006687","GO:1902389","GO:0015791"]},{"accession":"XP_030840759.1","go_terms":["GO:0032147","GO:0006351"]},{"accession":"XP_793312.2","go_terms":["GO:0009658","GO:0009644"]},{"accession":"XP_030828442.1","go_terms":["GO:0006435","GO:0006450","GO:0070143"]},{"accession":"XP_030840816.1","go_terms":["GO:0044655"]},{"accession":"XP_030845940.1","go_terms":[]},{"accession":"XP_030854105.1","go_terms":[]},{"accession":"XP_030855941.1","go_terms":["GO:0050966","GO:0019228","GO:0035024","GO:1900454","GO:0060081","GO:0071435","GO:1902260","GO:0051260","GO:0043149","GO:0050976","GO:0021759","GO:0021633","GO:0060372","GO:0045188","GO:0044335","GO:0071286","GO:0098914","GO:0086091"]},{"accession":"XP_030839311.1","go_terms":["GO:0090502","GO:0007565"]},{"accession":"XP_011679442.1","go_terms":["GO:0070230","GO:0070236","GO:0048262","GO:0002268","GO:0050728","GO:1905206","GO:0048297","GO:0098907","GO:0051798","GO:0071316","GO:0043123","GO:0060545","GO:0060546","GO:0009682","GO:0048536","GO:0046330","GO:0071285","GO:0036371","GO:0031663","GO:0002377","GO:0071447","GO:0010881","GO:0045651","GO:1903140","GO:2000630","GO:0006925","GO:0006924","GO:0071260","GO:0003283","GO:1902895","GO:0036462","GO:1902622","GO:0032494","GO:0090557","GO:0046784","GO:0044130","GO:0035994","GO:0007432","GO:0071359","GO:0071354","GO:2000310","GO:0098910","GO:0032760","GO:2000002","GO:0042489","GO:0051092","GO:2000338","GO:0006954","GO:0002755","GO:0031642","GO:0032088","GO:0006693","GO:1902042","GO:1902043","GO:0048148","GO:0072661","GO:0072660","GO:0030889","GO:0036289","GO:0086005","GO:0016064","GO:0033564","GO:2000663","GO:2000666","GO:0001783","GO:2001241","GO:0032675","GO:2001180","GO:0032747","GO:0032740","GO:0010936","GO:0034122","GO:0006977","GO:0021859","GO:0061057","GO:0086014","GO:0045351","GO:0002467","GO:0045060","GO:0038061","GO:0007249","GO:2001240","GO:0097527","GO:1900127","GO:0097252","GO:0002238","GO:2000341","GO:0060340","GO:0097192","GO:0070498","GO:0032496","GO:0097202","GO:0097049","GO:0042511","GO:0010467","GO:1901026","GO:0071550","GO:1903588","GO:0032464","GO:0097284","GO:0006919","GO:0010933","GO:0045080","GO:0045083","GO:0070926","GO:1990000","GO:0086070","GO:0010956","GO:0071356","GO:0097296","GO:0032757","GO:0070555","GO:2000454"]},{"accession":"XP_030844378.1","go_terms":["GO:0048313","GO:0006623","GO:0048490","GO:0042147","GO:0006888","GO:0051645","GO:1901998","GO:0006896","GO:0043473","GO:0006890","GO:0006897","GO:0016185","GO:0009615","GO:0008344","GO:0021691"]}],"graph":[["XP_030854105.1","XP_030830150.1",0.679],["XP_030854105.1","XP_030839580.1",0.512],["XP_030854105.1","XP_030855331.1",0.593],["XP_030854105.1","XP_030855981.1",0.597],["XP_030854105.1","XP_003726650.1",0.663],["XP_030855331.1","XP_030830150.1",0.691],["XP_030855331.1","XP_030832266.1",0.693],["XP_030855331.1","XP_030832311.1",0.759],["XP_030855331.1","XP_030839311.1",0.676],["XP_030855331.1","XP_030839580.1",0.795],["XP_030855331.1","XP_030840759.1",0.584],["XP_030855331.1","XP_030840816.1",0.62],["XP_030855331.1","XP_030844378.1",0.546],["XP_030855331.1","XP_030845940.1",0.753],["XP_030855331.1","XP_030850115.1",0.533],["XP_030855331.1","XP_798633.1",0.766],["XP_030855331.1","XP_793312.2",0.732],["XP_030855331.1","XP_784137.3",0.806],["XP_030855331.1","XP_030854167.1",0.824],["XP_030855331.1","XP_030855941.1",0.75],["XP_030855331.1","XP_030855981.1",0.53],["XP_030855331.1","XP_003726650.1",0.636],["XP_030855331.1","XP_003729809.2",0.696],["XP_030855331.1","XP_011679442.1",0.757],["XP_030855331.1","XP_030828442.1",0.568],["XP_030840759.1","XP_030839580.1",0.62],["XP_030840759.1","XP_030850115.1",0.636],["XP_030840759.1","XP_030855981.1",0.603],["XP_030840759.1","XP_784137.3",0.68],["XP_030840759.1","XP_793312.2",0.632],["XP_030840759.1","XP_003726650.1",0.513],["XP_030840759.1","XP_003729809.2",0.535],["XP_030840759.1","XP_011679442.1",0.542],["XP_030840759.1","XP_030830150.1",0.672],["XP_030840759.1","XP_030832266.1",0.67],["XP_793312.2","XP_030830150.1",0.637],["XP_793312.2","XP_030832266.1",0.759],["XP_793312.2","XP_030832311.1",0.799],["XP_793312.2","XP_030839311.1",0.583],["XP_793312.2","XP_030840816.1",0.652],["XP_793312.2","XP_030844378.1",0.545],["XP_793312.2","XP_030845940.1",0.511],["XP_793312.2","XP_030850115.1",0.695],["XP_793312.2","XP_030854167.1",0.579],["XP_793312.2","XP_030855941.1",0.572],["XP_793312.2","XP_784137.3",0.763],["XP_793312.2","XP_798633.1",0.714],["XP_793312.2","XP_003729809.2",0.511],["XP_030855941.1","XP_030830150.1",0.657],["XP_030855941.1","XP_030839580.1",0.531],["XP_030855941.1","XP_030844831.1",0.704],["XP_030855941.1","XP_798633.1",0.626],["XP_030855941.1","XP_003729809.2",0.51],["XP_030855941.1","XP_011679442.1",0.631],["XP_030855941.1","XP_030828442.1",0.508],["XP_798633.1","XP_030830150.1",0.726],["XP_798633.1","XP_030844831.1",0.568],["XP_798633.1","XP_030845940.1",0.782],["XP_798633.1","XP_030850115.1",0.757],["XP_798633.1","XP_030854167.1",0.744],["XP_798633.1","XP_784137.3",0.517],["XP_798633.1","XP_011679442.1",0.595],["XP_030839311.1","XP_030840816.1",0.569],["XP_030839311.1","XP_030850115.1",0.788],["XP_030839311.1","XP_030854167.1",0.559],["XP_030839311.1","XP_030855981.1",0.536],["XP_030839311.1","XP_784137.3",0.686],["XP_030839311.1","XP_003726650.1",0.574],["XP_030839311.1","XP_030832266.1",0.795],["XP_030839311.1","XP_030832311.1",0.564],["XP_030839311.1","XP_030839580.1",0.526],["XP_030844831.1","XP_030854167.1",0.593],["XP_030844831.1","XP_030828442.1",0.645],["XP_030844831.1","XP_030830150.1",0.914],["XP_030845940.1","XP_784137.3",0.663],["XP_030845940.1","XP_011679442.1",0.703],["XP_030845940.1","XP_030830150.1",0.522],["XP_030845940.1","XP_030832266.1",0.752],["XP_030832266.1","XP_030854167.1",0.705],["XP_030832266.1","XP_784137.3",0.819],["XP_030832266.1","XP_003726650.1",0.638],["XP_030832266.1","XP_003729809.2",0.722],["XP_030832266.1","XP_030828442.1",0.715],["XP_030832266.1","XP_030830150.1",0.577],["XP_030832266.1","XP_030832311.1",0.803],["XP_030832266.1","XP_030839580.1",0.601],["XP_030832266.1","XP_030840816.1",0.784],["XP_030832266.1","XP_030844378.1",0.779],["XP_030832266.1","XP_030850115.1",0.674],["XP_030854167.1","XP_030830150.1",0.791],["XP_030854167.1","XP_030832311.1",0.731],["XP_030854167.1","XP_030840816.1",0.525],["XP_030854167.1","XP_030844378.1",0.651],["XP_030854167.1","XP_784137.3",0.558],["XP_003729809.2","XP_011679442.1",0.604],["XP_003729809.2","XP_030839580.1",0.676],["XP_003729809.2","XP_030832311.1",0.542],["XP_003729809.2","XP_030830150.1",0.546],["XP_003729809.2","XP_784137.3",0.668],["XP_003729809.2","XP_030855981.1",0.505],["XP_030830150.1","XP_784137.3",0.761],["XP_030830150.1","XP_003726650.1",0.793],["XP_030830150.1","XP_011679442.1",0.665],["XP_030830150.1","XP_030828442.1",0.688],["XP_030830150.1","XP_030832311.1",0.569],["XP_030830150.1","XP_030850115.1",0.564],["XP_030828442.1","XP_030832311.1",0.645],["XP_030828442.1","XP_030840816.1",0.633],["XP_030840816.1","XP_030844378.1",0.624],["XP_030840816.1","XP_030850115.1",0.596],["XP_030840816.1","XP_784137.3",0.737],["XP_030840816.1","XP_030832311.1",0.531],["XP_011679442.1","XP_030839580.1",0.693],["XP_011679442.1","XP_784137.3",0.703],["XP_003726650.1","XP_030839580.1",0.802],["XP_003726650.1","XP_030855981.1",0.556],["XP_003726650.1","XP_784137.3",0.521],["XP_030844378.1","XP_030850115.1",0.572],["XP_030844378.1","XP_784137.3",0.526],["XP_030839580.1","XP_030850115.1",0.518],["XP_030839580.1","XP_030855981.1",0.761],["XP_030839580.1","XP_784137.3",0.672],["XP_030839580.1","XP_030832311.1",0.724],["XP_030850115.1","XP_784137.3",0.721],["XP_030850115.1","XP_030832311.1",0.634],["XP_784137.3","XP_030832311.1",0.638],["XP_784137.3","XP_030855981.1",0.563]],"all_go_terms":{"GO:0006446":3,"GO:1903955":1,"GO:0060625":1,"GO:0001731":2,"GO:0007250":1,"GO:0010387":2,"GO:0043161":2,"GO:0043248":1,"GO:0000338":2,"GO:0051726":1,"GO:0006281":1,"GO:1903894":1,"GO:0034286":1,"GO:0010950":1,"GO:1990182":1,"GO:0070452":1,"GO:0000266":1,"GO:0000398":1,"GO:0045471":1,"GO:1902906":1,"GO:0000393":1,"GO:0014067":1,"GO:0035871":1,"GO:0048140":1,"GO:0070537":1,"GO:0016559":1,"GO:0035522":1,"GO:0075522":1,"GO:0090305":1,"GO:0006313":1,"GO:1902389":2,"GO:0035621":2,"GO:0015791":2,"GO:0006687":2,"GO:0009751":2,"GO:0015695":2,"GO:0009816":2,"GO:0046836":2,"GO:0072488":2,"GO:0051092":2,"GO:0042489":2,"GO:0051798":2,"GO:2000341":2,"GO:0071285":2,"GO:0036462":2,"GO:0070926":2,"GO:0045083":2,"GO:0045080":2,"GO:0046784":2,"GO:0071316":2,"GO:0006925":2,"GO:0048297":2,"GO:0010933":2,"GO:0070555":2,"GO:2001240":2,"GO:0010881":2,"GO:0042511":2,"GO:0010956":2,"GO:1900127":2,"GO:1905206":2,"GO:0002755":2,"GO:0071359":2,"GO:0032747":2,"GO:0003283":2,"GO:0006924":2,"GO:0043123":2,"GO:0071447":2,"GO:1903140":2,"GO:0061057":2,"GO:0032464":2,"GO:0002268":2,"GO:0034122":2,"GO:0070230":2,"GO:0098907":2,"GO:0002377":2,"GO:0010467":2,"GO:2000663":2,"GO:0048148":2,"GO:0001783":2,"GO:0032494":2,"GO:0097202":2,"GO:1901026":2,"GO:2001180":2,"GO:0060340":2,"GO:1902042":2,"GO:0071354":2,"GO:0050728":2,"GO:0060545":2,"GO:0045651":2,"GO:0021859":2,"GO:1990000":2,"GO:0032757":2,"GO:0070498":2,"GO:0032740":2,"GO:0071356":2,"GO:0007432":2,"GO:0072661":2,"GO:0006919":2,"GO:0090557":2,"GO:1902043":2,"GO:0045060":2,"GO:2000310":2,"GO:0036289":2,"GO:0048536":2,"GO:0006977":2,"GO:0044130":2,"GO:0098910":2,"GO:0002467":2,"GO:0086014":2,"GO:0097296":2,"GO:2000666":2,"GO:0071550":2,"GO:1903588":2,"GO:0031663":2,"GO:0002238":2,"GO:0097252":2,"GO:0097284":2,"GO:0046330":2,"GO:0032675":2,"GO:0086070":2,"GO:0048262":2,"GO:0006954":2,"GO:1902622":2,"GO:0032760":2,"GO:0031642":2,"GO:0071260":2,"GO:0070236":2,"GO:2000338":2,"GO:2001241":2,"GO:0016064":2,"GO:0097049":2,"GO:0060546":2,"GO:0009682":2,"GO:2000454":2,"GO:0045351":2,"GO:2000002":2,"GO:0097527":2,"GO:0033564":2,"GO:0036371":2,"GO:0072660":2,"GO:0032496":2,"GO:0010936":2,"GO:0007249":2,"GO:1902895":2,"GO:2000630":2,"GO:0097192":2,"GO:0006693":2,"GO:0030889":2,"GO:0086005":2,"GO:0032088":2,"GO:0038061":2,"GO:0035994":2,"GO:1905618":1,"GO:0031053":1,"GO:2000507":1,"GO:0031047":1,"GO:0030422":1,"GO:1900363":1,"GO:0006370":1,"GO:0030307":1,"GO:0010801":1,"GO:0006406":1,"GO:0048026":1,"GO:0048574":1,"GO:1905606":1,"GO:0098789":1,"GO:0031442":1,"GO:1905696":1,"GO:1905537":1,"GO:0000184":1,"GO:0008315":1,"GO:0048136":1,"GO:1905612":1,"GO:0048820":1,"GO:0045292":1,"GO:0006351":1,"GO:0032147":1,"GO:0009644":1,"GO:0009658":1,"GO:0070143":1,"GO:0006450":1,"GO:0006435":1,"GO:0044655":1,"GO:1902260":1,"GO:0045188":1,"GO:0044335":1,"GO:1900454":1,"GO:0098914":1,"GO:0019228":1,"GO:0050966":1,"GO:0043149":1,"GO:0035024":1,"GO:0060372":1,"GO:0071286":1,"GO:0071435":1,"GO:0060081":1,"GO:0086091":1,"GO:0021759":1,"GO:0050976":1,"GO:0021633":1,"GO:0051260":1,"GO:0090502":1,"GO:0007565":1,"GO:0042147":1,"GO:0006897":1,"GO:0043473":1,"GO:0008344":1,"GO:0006888":1,"GO:0051645":1,"GO:0048490":1,"GO:0016185":1,"GO:0009615":1,"GO:0021691":1,"GO:0006623":1,"GO:1901998":1,"GO:0006896":1,"GO:0006890":1,"GO:0048313":1},"recipe_readded":[]}