{"hash":"2203060549482147797","title":"GPCR-Driven Cyclic Nucleotide Signaling","description":"These proteins are enriched for GPCR-related signaling, including adenylate cyclase-activating dopamine receptor signaling and receptor guanylyl cyclase signaling, with downstream cAMP and cGMP processes. They also relate to vasopressin-induced water homeostasis and neuromuscular balance, suggesting regulatory signaling roles in kidney and muscle function; a minor GPI anchor biosynthesis term is present but not central. Overall, the cluster maps to GPCR-driven cyclic nucleotide signaling.","confidence":"High","size":19,"edges":82,"triangles":113,"max_degree":12,"top_function":null,"members":[{"accession":"XP_030829913.1","go_terms":["GO:1904322","GO:0007616","GO:0071380","GO:0007591","GO:0034199","GO:0035556","GO:0010353","GO:0090328","GO:0008355","GO:0007340","GO:0050885","GO:0003091","GO:0001582","GO:0035811","GO:0006171","GO:0007608","GO:0001661","GO:0071870","GO:0061178","GO:0006182","GO:0071361","GO:0071377","GO:0016199","GO:0001973","GO:1904117","GO:0007191","GO:0007190","GO:0007195","GO:0052565","GO:0009785","GO:0007168","GO:0070483","GO:1900194","GO:0030828","GO:0006355","GO:0071880"]},{"accession":"XP_030845916.1","go_terms":[]},{"accession":"XP_003724629.1","go_terms":["GO:1904103","GO:0006506"]},{"accession":"XP_030829095.1","go_terms":["GO:1904721","GO:1990441","GO:1902065","GO:1902045","GO:0060702","GO:1902236","GO:1902042","GO:1903298","GO:0032469","GO:0051025","GO:0090005","GO:0021681","GO:0021702","GO:0010523"]},{"accession":"XP_030839280.1","go_terms":["GO:0042552","GO:0043652","GO:0031133","GO:0048741","GO:0070782","GO:0010961"]},{"accession":"XP_003724911.2","go_terms":[]},{"accession":"XP_030833295.1","go_terms":["GO:0034633","GO:0051180"]},{"accession":"XP_030843141.1","go_terms":[]},{"accession":"XP_011673371.2","go_terms":[]},{"accession":"XP_784211.2","go_terms":[]},{"accession":"XP_030839753.1","go_terms":["GO:0006506"]},{"accession":"XP_030842089.1","go_terms":["GO:0006888","GO:0006486","GO:0031505","GO:0045053"]},{"accession":"XP_030854185.1","go_terms":["GO:0071586"]},{"accession":"XP_796799.1","go_terms":["GO:0030148","GO:0007254","GO:0071529","GO:0007249","GO:0045070","GO:0030497","GO:0046726","GO:0007266","GO:0042761"]},{"accession":"XP_003727917.2","go_terms":["GO:0007186","GO:0019236"]},{"accession":"XP_003728461.1","go_terms":[]},{"accession":"XP_030840006.1","go_terms":["GO:0009306","GO:0016192"]},{"accession":"XP_030848105.1","go_terms":["GO:0010224","GO:0009926"]},{"accession":"XP_030848857.1","go_terms":[]}],"graph":[["XP_030829095.1","XP_003727917.2",0.513],["XP_030829095.1","XP_030829913.1",0.512],["XP_030829095.1","XP_030833295.1",0.523],["XP_030829095.1","XP_030840006.1",0.589],["XP_030829095.1","XP_030843141.1",0.563],["XP_030829095.1","XP_030845916.1",0.533],["XP_030829095.1","XP_030848105.1",0.565],["XP_030829095.1","XP_030848857.1",0.5],["XP_030829095.1","XP_784211.2",0.576],["XP_030829095.1","XP_796799.1",0.536],["XP_030845916.1","XP_030839753.1",0.552],["XP_030845916.1","XP_030840006.1",0.503],["XP_030845916.1","XP_030842089.1",0.577],["XP_030845916.1","XP_030843141.1",0.514],["XP_030845916.1","XP_030848105.1",0.526],["XP_030845916.1","XP_784211.2",0.517],["XP_030845916.1","XP_003724629.1",0.509],["XP_030845916.1","XP_003728461.1",0.588],["XP_030845916.1","XP_011673371.2",0.508],["XP_030845916.1","XP_030829913.1",0.57],["XP_030845916.1","XP_030833295.1",0.522],["XP_030839280.1","XP_030843141.1",0.503],["XP_030839280.1","XP_030854185.1",0.556],["XP_030839280.1","XP_784211.2",0.562],["XP_030839280.1","XP_796799.1",0.523],["XP_030839280.1","XP_003724629.1",0.508],["XP_030839280.1","XP_003724911.2",0.503],["XP_030839280.1","XP_003727917.2",0.504],["XP_030839280.1","XP_003728461.1",0.501],["XP_030839280.1","XP_030829913.1",0.544],["XP_011673371.2","XP_003724911.2",0.538],["XP_011673371.2","XP_030839753.1",0.533],["XP_011673371.2","XP_030833295.1",0.546],["XP_011673371.2","XP_030848105.1",0.563],["XP_011673371.2","XP_030840006.1",0.5],["XP_003724911.2","XP_030833295.1",0.529],["XP_003724911.2","XP_030848857.1",0.518],["XP_003724911.2","XP_796799.1",0.505],["XP_030848105.1","XP_030843141.1",0.502],["XP_030848105.1","XP_030848857.1",0.507],["XP_030848105.1","XP_796799.1",0.5],["XP_030848105.1","XP_003727917.2",0.527],["XP_030848105.1","XP_003728461.1",0.543],["XP_030848105.1","XP_030829913.1",0.55],["XP_030848105.1","XP_030833295.1",0.518],["XP_784211.2","XP_030833295.1",0.561],["XP_784211.2","XP_030839753.1",0.569],["XP_784211.2","XP_030840006.1",0.543],["XP_784211.2","XP_030843141.1",0.541],["XP_784211.2","XP_030854185.1",0.572],["XP_784211.2","XP_796799.1",0.563],["XP_784211.2","XP_003727917.2",0.527],["XP_784211.2","XP_003728461.1",0.582],["XP_030839753.1","XP_030854185.1",0.522],["XP_030839753.1","XP_003728461.1",0.571],["XP_030839753.1","XP_030829913.1",0.509],["XP_030839753.1","XP_030833295.1",0.507],["XP_030843141.1","XP_030854185.1",0.501],["XP_030843141.1","XP_003724629.1",0.517],["XP_030843141.1","XP_030829913.1",0.525],["XP_030848857.1","XP_030842089.1",0.561],["XP_030848857.1","XP_796799.1",0.527],["XP_030848857.1","XP_003724629.1",0.536],["XP_030848857.1","XP_003728461.1",0.527],["XP_003724629.1","XP_030842089.1",0.533],["XP_003724629.1","XP_796799.1",0.604],["XP_003724629.1","XP_030854185.1",0.507],["XP_030833295.1","XP_796799.1",0.521],["XP_030833295.1","XP_030854185.1",0.54],["XP_030833295.1","XP_003727917.2",0.532],["XP_030833295.1","XP_030829913.1",0.522],["XP_030829913.1","XP_003727917.2",0.521],["XP_030829913.1","XP_0037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