{"hash":"1936667457505912960","title":"DNA Repair and Cell Cycle Checkpoints","description":"This cluster is dominated by terms related to DNA damage response and genome integrity: nucleotide-excision repair, various DNA replication and checkpoint signaling (mitotic/meiosis), regulation of DNA replication, telomere maintenance, and protein phosphorylation as a regulatory mechanism. The presence of ionizing radiation response and meiotic checkpoints further supports a cohesive theme of detecting/repairing DNA damage and coordinating replication with cell cycle progression, including telomere maintenance. Embryo development-related terms appear less central but may reflect broader roles in genome integrity during development.","confidence":"High","size":25,"edges":275,"triangles":1826,"max_degree":24,"top_function":null,"members":[{"accession":"XP_011662813.2","go_terms":[]},{"accession":"XP_030828780.1","go_terms":["GO:0033314","GO:0006468","GO:0035038","GO:0006289","GO:0009790","GO:0008156","GO:0009411","GO:0044778","GO:0000722","GO:0071479","GO:0031573","GO:0000724","GO:0001932"]},{"accession":"XP_030834454.1","go_terms":[]},{"accession":"XP_030844432.1","go_terms":[]},{"accession":"XP_030833288.1","go_terms":[]},{"accession":"XP_786110.2","go_terms":["GO:0017183","GO:0050843"]},{"accession":"XP_003729462.2","go_terms":[]},{"accession":"XP_030837485.1","go_terms":["GO:0034472","GO:0090435","GO:0030317","GO:0080154","GO:0007052","GO:0051663","GO:0051642","GO:0046843"]},{"accession":"XP_030837603.1","go_terms":["GO:0046718","GO:0006310","GO:0006278","GO:0075713","GO:0075732","GO:0015074","GO:0006260","GO:0039651","GO:1903704"]},{"accession":"XP_786829.1","go_terms":["GO:0033314","GO:0006468","GO:0035038","GO:0006289","GO:0009790","GO:0008156","GO:0009411","GO:0044778","GO:0000722","GO:0071479","GO:0031573","GO:0000724","GO:0001932"]},{"accession":"XP_003727877.2","go_terms":[]},{"accession":"XP_030845176.1","go_terms":[]},{"accession":"XP_003724888.2","go_terms":[]},{"accession":"XP_030844115.1","go_terms":["GO:1902043","GO:0072661","GO:0072660","GO:0060307","GO:0003283","GO:0036309","GO:0086005","GO:0007432","GO:0001825","GO:0033564","GO:0098907","GO:0021859","GO:2001240","GO:0071230","GO:0035156","GO:0006915","GO:0034260","GO:0061462","GO:0036059","GO:0006977","GO:2001222","GO:0086070","GO:0010650","GO:0086014","GO:1900827","GO:0036371","GO:0098910","GO:0010881","GO:0032007","GO:0070230","GO:0070236","GO:0048262","GO:0002268","GO:0050728","GO:1905206","GO:0048297","GO:0051798","GO:0071316","GO:0043123","GO:0060545","GO:0060546","GO:0009682","GO:0048536","GO:0046330","GO:0071285","GO:0031663","GO:0002377","GO:0071447","GO:0045651","GO:1903140","GO:2000630","GO:0006925","GO:0006924","GO:0071260","GO:1902895","GO:0036462","GO:1902622","GO:0032494","GO:0090557","GO:0046784","GO:0044130","GO:0035994","GO:0071359","GO:0071354","GO:2000310","GO:0032760","GO:2000002","GO:0042489","GO:0051092","GO:2000338","GO:0006954","GO:0002755","GO:0031642","GO:0032088","GO:0006693","GO:1902042","GO:0048148","GO:0030889","GO:0036289","GO:0016064","GO:2000663","GO:2000666","GO:0001783","GO:2001241","GO:0032675","GO:2001180","GO:0032747","GO:0032740","GO:0010936","GO:0034122","GO:0061057","GO:0045351","GO:0002467","GO:0045060","GO:0038061","GO:0007249","GO:0097527","GO:1900127","GO:0097252","GO:0002238","GO:2000341","GO:0060340","GO:0097192","GO:0070498","GO:0032496","GO:0097202","GO:0097049","GO:0042511","GO:0010467","GO:1901026","GO:0071550","GO:1903588","GO:0032464","GO:0097284","GO:0006919","GO:0010933","GO:0045080","GO:0045083","GO:0070926","GO:1990000","GO:0010956","GO:0071356","GO:0097296","GO:0032757","GO:0070555","GO:2000454"]},{"accession":"XP_780589.4","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"XP_030839274.1","go_terms":[]},{"accession":"XP_030845178.1","go_terms":[]},{"accession":"XP_782072.2","go_terms":[]},{"accession":"XP_003730057.2","go_terms":["GO:0048767","GO:0071816"]},{"accession":"XP_011667114.1","go_terms":["GO:0006561","GO:0019877","GO:0016310","GO:1904262","GO:0009090","GO:0009089","GO:0009088","GO:1903577"]},{"accession":"XP_030829343.1","go_terms":[]},{"accession":"XP_030842356.1","go_terms":["GO:0000184"]},{"accession":"XP_030848279.1","go_terms":["GO:0042475","GO:0007420","GO:0007035","GO:0030097","GO:0022008"]},{"accession":"XP_003730337.1","go_terms":["GO:0002755","GO:0045410","GO:2000340","GO:0070671","GO:0090073","GO:0034137","GO:2000494","GO:0032738","GO:0034145","GO:0002781","GO:0071651","GO:0071650","GO:0035669","GO:0070935","GO:0035665","GO:0043123","GO:0006461","GO:0070262","GO:0050790","GO:1903538","GO:0042176","GO:0051754","GO:0007143","GO:0051306","GO:2001241","GO:0051232","GO:0008033","GO:0008612","GO:0033674","GO:0006610","GO:0000060","GO:0000188","GO:0051028","GO:0038202","GO:0097711","GO:0042518","GO:0007084","GO:0060561","GO:0071230","GO:0060188","GO:0006607","GO:0051292","GO:0043547","GO:0006335","GO:0006275","GO:0001938","GO:0045945","GO:0006672"]},{"accession":"XP_030834407.1","go_terms":[]}],"graph":[["XP_030834407.1","XP_780589.4",0.65],["XP_030834407.1","XP_782072.2",0.671],["XP_030834407.1","XP_786110.2",0.6],["XP_030834407.1","XP_786829.1",0.511],["XP_030834407.1","XP_003724888.2",0.616],["XP_030834407.1","XP_003729462.2",0.586],["XP_030834407.1","XP_003730337.1",0.628],["XP_030834407.1","XP_011662813.2",0.63],["XP_030834407.1","XP_011667114.1",0.592],["XP_030834407.1","XP_030829343.1",0.615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