{"hash":"1818319610361715386","title":"Ubiquitin-Driven TNF/NF-\u03baB Signaling and Endocytosis","description":"The cluster centers on ubiquitination processes (protein ubiquitination, autoubiquitination, K48-linked ubiquitination) and TNF-mediated signaling with I-kappaB phosphorylation, pointing to NF-\u03baB\u2013related regulation. It also includes receptor-mediated endocytosis, suggesting roles in trafficking; some terms touch cell cycle/checkpoint components, which can be linked to ubiquitin regulation. Overall, the group seems defined by ubiquitin-dependent signaling and endocytic regulation rather than a single, narrow function.","confidence":"Medium","size":21,"edges":99,"triangles":196,"max_degree":17,"top_function":null,"members":[{"accession":"XP_001198150.3","go_terms":["GO:0034501","GO:0051382","GO:0051315","GO:0051301","GO:0000278"]},{"accession":"XP_001200580.3","go_terms":["GO:1902306","GO:0033209","GO:0032088","GO:0048227","GO:1902072","GO:2000009"]},{"accession":"XP_030837655.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0031030","GO:0032186","GO:1902364","GO:0000921","GO:0031578","GO:0097271","GO:0044810","GO:0090337","GO:0016567","GO:0039536","GO:0002250","GO:0033151","GO:0033209","GO:0009048","GO:0036205","GO:0046328","GO:2000620","GO:0042981","GO:0007250","GO:0070512","GO:0085020","GO:0070535","GO:1903265","GO:1903762","GO:1903721","GO:1901253","GO:0090073","GO:0007039","GO:0006879","GO:1904382","GO:0006898","GO:0042135","GO:0035609","GO:0098707","GO:0045830","GO:0033572","GO:0031293","GO:0010103","GO:0006760"]},{"accession":"XP_030837657.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0031030","GO:0032186","GO:1902364","GO:0000921","GO:0031578","GO:0097271","GO:0044810","GO:0090337","GO:0016567","GO:0039536","GO:0002250","GO:0033151","GO:0033209","GO:0009048","GO:0036205","GO:0046328","GO:2000620","GO:0042981","GO:0007250","GO:0070512","GO:0085020","GO:0070535","GO:1903265","GO:1903762","GO:1903721","GO:1901253","GO:0090073","GO:0007039","GO:0006879","GO:1904382","GO:0006898","GO:0042135","GO:0035609","GO:0098707","GO:0045830","GO:0033572","GO:0031293","GO:0010103","GO:0006760"]},{"accession":"XP_030838613.1","go_terms":["GO:0099515","GO:0031115","GO:1990735","GO:0003025","GO:2001137","GO:0035023","GO:0009652","GO:1902896","GO:0043087","GO:0071963","GO:0021692","GO:0070649","GO:0090286","GO:1900024","GO:0051693","GO:1903033","GO:0051695","GO:0048633","GO:0016203","GO:1901018","GO:0021564","GO:0051661","GO:0014732","GO:0045214","GO:0051666","GO:0021563","GO:0030042","GO:1904825","GO:1902396","GO:0016055","GO:0001951","GO:0021873","GO:0010735","GO:1901078","GO:0086097","GO:1903475","GO:1904025","GO:1903478","GO:0032532","GO:0048734","GO:2000009","GO:0055013","GO:0030989","GO:0021629","GO:0030035","GO:0051639","GO:0090307","GO:0048041","GO:0014728","GO:0045769","GO:0000743","GO:0007026","GO:0031532","GO:0006887","GO:0048549","GO:0070493","GO:1900042","GO:0007182","GO:1902405","GO:1904706","GO:1900159","GO:1904519","GO:0014809","GO:1903477","GO:0061171","GO:0030437","GO:0007155","GO:0051764","GO:0030048","GO:0000742","GO:0019417","GO:0031448","GO:0014894","GO:0021869","GO:0071670","GO:0032458"]},{"accession":"XP_030838744.1","go_terms":[]},{"accession":"XP_030844318.1","go_terms":[]},{"accession":"XP_003723527.1","go_terms":[]},{"accession":"NP_001138966.1","go_terms":["GO:0048749","GO:0030324","GO:0008101","GO:0048085","GO:0001658","GO:0072138","GO:0045880","GO:0060976","GO:0046326","GO:0030282","GO:0009948","GO:0040037","GO:0072203","GO:0030200","GO:2001261","GO:0090090","GO:0048190","GO:2000096","GO:0030316","GO:0045879","GO:0060030","GO:0035116","GO:0008052","GO:0048132","GO:0010171","GO:0030513","GO:0016055","GO:0003379","GO:0045570","GO:0072180","GO:1902726","GO:1902724"]},{"accession":"XP_030847811.1","go_terms":["GO:0060544","GO:0000122","GO:0034121","GO:0043066","GO:0000209","GO:0071157","GO:0050689","GO:0030308","GO:0000266","GO:0051898","GO:1903861","GO:0090141","GO:1901028","GO:0033235","GO:0043123","GO:1904215","GO:0006919","GO:1904925","GO:0007257","GO:0051646","GO:0060339","GO:0010637","GO:0031648","GO:0051881","GO:0071360","GO:0071650"]},{"accession":"XP_030840469.1","go_terms":["GO:0046007","GO:0034276","GO:0070233","GO:0002830","GO:0036269","GO:0032496","GO:0002534","GO:0002666","GO:0032693","GO:0034354","GO:0019441","GO:0002678","GO:0070234","GO:0006954","GO:0055114","GO:0007565","GO:0002376","GO:0033555","GO:0032735"]},{"accession":"XP_030830270.1","go_terms":["GO:0016310","GO:0015937"]},{"accession":"XP_030837656.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0031030","GO:0032186","GO:1902364","GO:0000921","GO:0031578","GO:0097271","GO:0044810","GO:0090337","GO:0016567","GO:0039536","GO:0002250","GO:0033151","GO:0033209","GO:0009048","GO:0036205","GO:0046328","GO:2000620","GO:0042981","GO:0007250","GO:0070512","GO:0085020","GO:0070535","GO:1903265","GO:1903762","GO:1903721","GO:1901253","GO:0090073","GO:0007039","GO:0006879","GO:1904382","GO:0006898","GO:0042135","GO:0035609","GO:0098707","GO:0045830","GO:0033572","GO:0031293","GO:0010103","GO:0006760"]},{"accession":"XP_030846748.1","go_terms":[]},{"accession":"XP_003726875.2","go_terms":["GO:0035621","GO:0009751","GO:0009816","GO:0072488","GO:0046836","GO:0015695","GO:0006687","GO:1902389","GO:0015791"]},{"accession":"XP_030839426.1","go_terms":[]},{"accession":"XP_030844321.1","go_terms":[]},{"accession":"XP_030833099.1","go_terms":["GO:0061577","GO:0048060","GO:0009454","GO:0019228","GO:0086043","GO:0086045","GO:0086047","GO:0086048","GO:0060081","GO:0006828","GO:0060083","GO:0048266","GO:0010961","GO:0048265","GO:0003151","GO:0021590","GO:0007216","GO:0098907","GO:1903444","GO:1902303","GO:0021633","GO:0051592","GO:0045188","GO:0071321","GO:0071320","GO:0098914","GO:0098911","GO:0098910","GO:1902259","GO:0060307","GO:1900454","GO:0042310","GO:0097497","GO:0040040","GO:0034767","GO:0016340","GO:0080141","GO:0086029","GO:0043029","GO:0001964","GO:0019233","GO:0050955","GO:0014808","GO:0060372","GO:1901594","GO:0060371","GO:0098912","GO:0034651","GO:0048016","GO:0097623","GO:0071502","GO:0034465","GO:0050960","GO:0050966","GO:0050968","GO:0001666","GO:0003220","GO:0008627","GO:0086002","GO:0071642","GO:0002024","GO:1903244","GO:0050976","GO:0030317","GO:0098703","GO:0021679","GO:0009409","GO:0086016","GO:0032342","GO:0071651","GO:0086091","GO:0060453","GO:1990573","GO:2000340","GO:0098719","GO:0043931","GO:0014051","GO:0002724","GO:1903759","GO:0007275","GO:0003031","GO:0051260","GO:0051262","GO:0071313","GO:0043588","GO:0050856","GO:0021750","GO:0030103","GO:0051928","GO:0097050","GO:0010754"]},{"accession":"XP_030838738.1","go_terms":[]},{"accession":"XP_794367.2","go_terms":[]},{"accession":"XP_030850245.1","go_terms":["GO:1904938","GO:0060347","GO:0099558","GO:0048105","GO:0061743","GO:0032792","GO:0060732","GO:0019933","GO:0072520","GO:0001525","GO:0060133","GO:0060490","GO:0006171","GO:0007189","GO:0043129","GO:2001223","GO:0021796","GO:0048496","GO:0036515","GO:0036514","GO:0021819","GO:0090210","GO:0048469","GO:0090251","GO:0060488","GO:0060489","GO:0030252","GO:0060124","GO:0007156","GO:0022900","GO:0071329","GO:0010579","GO:0045777","GO:0007200","GO:1901223","GO:0010573","GO:0007204","GO:0051867","GO:0070528","GO:0051458","GO:1900747","GO:0016525","GO:0051965","GO:2000852","GO:0001764","GO:0043031","GO:0002076","GO:0022011","GO:0035025","GO:0007413","GO:0031987","GO:0045176","GO:0042220","GO:0007266","GO:0042249","GO:0090179","GO:0021801"]}],"graph":[["XP_003723527.1","XP_001198150.3",0.558],["XP_003723527.1","XP_001200580.3",0.676],["XP_003723527.1","XP_003726875.2",0.791],["XP_003723527.1","XP_030838744.1",0.602],["XP_003723527.1","XP_030833099.1",0.518],["XP_003723527.1","XP_030847811.1",0.64],["XP_003723527.1","XP_030846748.1",0.593],["XP_003723527.1","XP_030844318.1",0.859],["XP_003723527.1","XP_030844321.1",0.657],["XP_030847811.1","XP_030837656.1",0.541],["XP_030847811.1","XP_030837657.1",0.541],["XP_030847811.1","XP_030844318.1",0.546],["XP_030847811.1","XP_001198150.3",0.575],["XP_030847811.1","XP_001200580.3",0.507],["XP_030847811.1","XP_030830270.1",0.502],["XP_030847811.1","XP_030833099.1",0.508],["XP_001198150.3","XP_001200580.3",0.564],["XP_001198150.3","XP_003726875.2",0.631],["XP_001198150.3","XP_030839426.1",0.709],["XP_001198150.3","XP_030838738.1",0.672],["XP_001198150.3","XP_030838744.1",0.691],["XP_001198150.3","XP_030850245.1",0.629],["XP_001198150.3","XP_030846748.1",0.534],["XP_001198150.3","XP_030844318.1",0.668],["XP_001198150.3","XP_030844321.1",0.692],["XP_001198150.3","XP_794367.2",0.828],["XP_030833099.1","NP_001138966.1",0.655],["XP_030833099.1","XP_030850245.1",0.53],["XP_030833099.1","XP_030844318.1",0.589],["XP_030833099.1","XP_030844321.1",0.607],["XP_030833099.1","XP_030840469.1",0.531],["XP_030837655.1","XP_030840469.1",0.612],["XP_030837655.1","XP_030844318.1",0.701],["XP_030837655.1","XP_030844321.1",0.67],["XP_030837655.1","XP_030846748.1",0.687],["XP_030837655.1","XP_030850245.1",0.696],["XP_030837655.1","NP_001138966.1",0.584],["XP_030837655.1","XP_001200580.3",0.552],["XP_030837655.1","XP_030830270.1",0.556],["XP_030837655.1","XP_030839426.1",0.54],["XP_030837655.1","XP_030837656.1",0.619],["XP_030837655.1","XP_030837657.1",0.591],["XP_030837655.1","XP_030838613.1",0.623],["XP_030837655.1","XP_030838744.1",0.519],["XP_030846748.1","XP_030837656.1",0.703],["XP_030846748.1","XP_030837657.1",0.594],["XP_030846748.1","XP_030838744.1",0.524],["XP_030846748.1","XP_030844318.1",0.624],["XP_030846748.1","XP_030844321.1",0.645],["XP_030846748.1","NP_001138966.1",0.63],["XP_030846748.1","XP_001200580.3",0.575],["XP_030846748.1","XP_003726875.2",0.507],["XP_001200580.3","XP_030838744.1",0.687],["XP_001200580.3","XP_030837656.1",0.533],["XP_001200580.3","XP_030830270.1",0.525],["XP_001200580.3","XP_030844318.1",0.67],["XP_001200580.3","XP_030844321.1",0.598],["XP_001200580.3","XP_794367.2",0.526],["XP_030844321.1","XP_030837656.1",0.673],["XP_030844321.1","XP_030837657.1",0.669],["XP_030844321.1","XP_030838738.1",0.612],["XP_030844321.1","XP_030838744.1",0.72],["XP_030844321.1","XP_030839426.1",0.513],["XP_030844321.1","XP_030840469.1",0.52],["XP_030844321.1","XP_030844318.1",0.695],["XP_030844321.1","XP_030850245.1",0.617],["XP_030844321.1","XP_794367.2",0.636],["XP_030844321.1","NP_001138966.1",0.733],["XP_030844321.1","XP_003726875.2",0.567],["XP_030839426.1","NP_001138966.1",0.561],["XP_030839426.1","XP_030837656.1",0.548],["XP_030839426.1","XP_030837657.1",0.514],["XP_030839426.1","XP_030838738.1",0.556],["XP_030840469.1","XP_030837656.1",0.581],["XP_030840469.1","XP_030837657.1",0.553],["XP_030840469.1","XP_030844318.1",0.539],["XP_030840469.1","NP_001138966.1",0.615],["XP_003726875.2","XP_030838744.1",0.509],["XP_003726875.2","XP_794367.2",0.607],["XP_030830270.1","XP_030837656.1",0.597],["XP_030838738.1","XP_030844318.1",0.533],["XP_030838738.1","XP_794367.2",0.552],["XP_030837656.1","XP_030844318.1",0.664],["XP_030837656.1","XP_030850245.1",0.679],["XP_030837656.1","NP_001138966.1",0.587],["XP_030837656.1","XP_030837657.1",0.581],["XP_030837656.1","XP_030838613.1",0.593],["XP_030837656.1","XP_030838744.1",0.521],["NP_001138966.1","XP_030837657.1",0.595],["NP_001138966.1","XP_030838744.1",0.713],["NP_001138966.1","XP_030844318.1",0.714],["NP_001138966.1","XP_030850245.1",0.556],["NP_001138966.1","XP_794367.2",0.568],["XP_030837657.1","XP_030844318.1",0.654],["XP_030837657.1","XP_030850245.1",0.668],["XP_030844318.1","XP_030838744.1",0.69],["XP_030844318.1","XP_030850245.1",0.622],["XP_030844318.1","XP_794367.2",0.655],["XP_794367.2","XP_030838744.1",0.537]],"all_go_terms":{"GO:0034501":1,"GO:0000278":1,"GO:0051382":1,"GO:0051301":1,"GO:0051315":1,"GO:1902306":1,"GO:0048227":1,"GO:0032088":1,"GO:1902072":1,"GO:2000009":2,"GO:0033209":4,"GO:2000620":3,"GO:0016567":3,"GO:1903721":3,"GO:0051865":3,"GO:1900095":3,"GO:0032186":3,"GO:0070936":3,"GO:0044810":3,"GO:0006898":3,"GO:0098707":3,"GO:0033572":3,"GO:1901253":3,"GO:0000921":3,"GO:0010103":3,"GO:1902364":3,"GO:0016558":3,"GO:0030433":3,"GO:0031293":3,"GO:0031578":3,"GO:0042135":3,"GO:0002250":3,"GO:1903265":3,"GO:0085020":3,"GO:1903762":3,"GO:0007039":3,"GO:0045830":3,"GO:0036205":3,"GO:0033151":3,"GO:0035609":3,"GO:0097271":3,"GO:0046621":3,"GO:0060816":3,"GO:0090337":3,"GO:0042981":3,"GO:0038018":3,"GO:0031030":3,"GO:0009048":3,"GO:0070535":3,"GO:0039536":3,"GO:0007250":3,"GO:0006760":3,"GO:0046328":3,"GO:0070512":3,"GO:0006879":3,"GO:0042787":3,"GO:1904382":3,"GO:0090073":3,"GO:0007182":1,"GO:0051764":1,"GO:0001951":1,"GO:1902896":1,"GO:0045769":1,"GO:0071963":1,"GO:0099515":1,"GO:0035023":1,"GO:0021629":1,"GO:0014732":1,"GO:0000742":1,"GO:0090286":1,"GO:0031115":1,"GO:0000743":1,"GO:1900159":1,"GO:0051666":1,"GO:0045214":1,"GO:0014728":1,"GO:0090307":1,"GO:0030437":1,"GO:0048633":1,"GO:0021873":1,"GO:1901078":1,"GO:0021869":1,"GO:0051693":1,"GO:0051661":1,"GO:1900024":1,"GO:1902396":1,"GO:0007026":1,"GO:1903477":1,"GO:0031448":1,"GO:1904706":1,"GO:0030042":1,"GO:0051695":1,"GO:0021563":1,"GO:0010735":1,"GO:0009652":1,"GO:0048734":1,"GO:2001137":1,"GO:0051639":1,"GO:0007155":1,"GO:1904519":1,"GO:0032458":1,"GO:0003025":1,"GO:1900042":1,"GO:1903475":1,"GO:0061171":1,"GO:0014894":1,"GO:0031532":1,"GO:0021564":1,"GO:1990735":1,"GO:0048041":1,"GO:0071670":1,"GO:1904825":1,"GO:1903478":1,"GO:0070649":1,"GO:0014809":1,"GO:0070493":1,"GO:1904025":1,"GO:0030989":1,"GO:0019417":1,"GO:0016203":1,"GO:0032532":1,"GO:0055013":1,"GO:0030035":1,"GO:0021692":1,"GO:1901018":1,"GO:0016055":2,"GO:0006887":1,"GO:1902405":1,"GO:0048549":1,"GO:0086097":1,"GO:0030048":1,"GO:0043087":1,"GO:1903033":1,"GO:0008101":1,"GO:2001261":1,"GO:0040037":1,"GO:0030513":1,"GO:0010171":1,"GO:0003379":1,"GO:0048749":1,"GO:0072203":1,"GO:0035116":1,"GO:0045570":1,"GO:0030324":1,"GO:0072138":1,"GO:0045879":1,"GO:2000096":1,"GO:0030316":1,"GO:0048190":1,"GO:0048085":1,"GO:0046326":1,"GO:0060976":1,"GO:0072180":1,"GO:0048132":1,"GO:0060030":1,"GO:0045880":1,"GO:0001658":1,"GO:0030200":1,"GO:0009948":1,"GO:0090090":1,"GO:1902726":1,"GO:0030282":1,"GO:0008052":1,"GO:1902724":1,"GO:0060544":1,"GO:1904215":1,"GO:0071650":1,"GO:0000122":1,"GO:0010637":1,"GO:0000266":1,"GO:0043066":1,"GO:0033235":1,"GO:0050689":1,"GO:0030308":1,"GO:0000209":1,"GO:1904925":1,"GO:0051881":1,"GO:0071360":1,"GO:0007257":1,"GO:0060339":1,"GO:0051646":1,"GO:1903861":1,"GO:0043123":1,"GO:0090141":1,"GO:0071157":1,"GO:0051898":1,"GO:0031648":1,"GO:0034121":1,"GO:1901028":1,"GO:0006919":1,"GO:0033555":1,"GO:0070234":1,"GO:0070233":1,"GO:0002534":1,"GO:0019441":1,"GO:0055114":1,"GO:0034354":1,"GO:0036269":1,"GO:0032496":1,"GO:0046007":1,"GO:0002666":1,"GO:0006954":1,"GO:0002376":1,"GO:0007565":1,"GO:0032693":1,"GO:0032735":1,"GO:0002678":1,"GO:0034276":1,"GO:0002830":1,"GO:0016310":1,"GO:0015937":1,"GO:1902389":1,"GO:0035621":1,"GO:0015791":1,"GO:0006687":1,"GO:0009751":1,"GO:0015695":1,"GO:0009816":1,"GO:0046836":1,"GO:0072488":1,"GO:1903244":1,"GO:1901594":1,"GO:0086045":1,"GO:0060453":1,"GO:0071313":1,"GO:0001666":1,"GO:0010961":1,"GO:0050966":1,"GO:0001964":1,"GO:0080141":1,"GO:0098703":1,"GO:0007216":1,"GO:0006828":1,"GO:0098719":1,"GO:0030103":1,"GO:0048016":1,"GO:0002724":1,"GO:0009454":1,"GO:0043588":1,"GO:1902259":1,"GO:0019233":1,"GO:0050960":1,"GO:0098907":1,"GO:0051260":1,"GO:0003031":1,"GO:0098911":1,"GO:0019228":1,"GO:0021590":1,"GO:0086043":1,"GO:0034465":1,"GO:0032342":1,"GO:0060081":1,"GO:0042310":1,"GO:0021750":1,"GO:0071642":1,"GO:0061577":1,"GO:0021633":1,"GO:0043931":1,"GO:0097050":1,"GO:0034651":1,"GO:0034767":1,"GO:0050955":1,"GO:0002024":1,"GO:0021679":1,"GO:0030317":1,"GO:0051262":1,"GO:0098910":1,"GO:1903444":1,"GO:0048265":1,"GO:0097623":1,"GO:1902303":1,"GO:0010754":1,"GO:0060307":1,"GO:2000340":1,"GO:0051928":1,"GO:0086091":1,"GO:0071502":1,"GO:0051592":1,"GO:0016340":1,"GO:0098914":1,"GO:0086029":1,"GO:0086016":1,"GO:0048060":1,"GO:0014051":1,"GO:0071321":1,"GO:0008627":1,"GO:0086048":1,"GO:0048266":1,"GO:0014808":1,"GO:0086002":1,"GO:0071320":1,"GO:0040040":1,"GO:0050976":1,"GO:0050856":1,"GO:0045188":1,"GO:1900454":1,"GO:0097497":1,"GO:0003151":1,"GO:0050968":1,"GO:0043029":1,"GO:1990573":1,"GO:0003220":1,"GO:0060083":1,"GO:0071651":1,"GO:0060371":1,"GO:0060372":1,"GO:0007275":1,"GO:0098912":1,"GO:0009409":1,"GO:1903759":1,"GO:0086047":1,"GO:0051867":1,"GO:0051458":1,"GO:0031987":1,"GO:0006171":1,"GO:0072520":1,"GO:0019933":1,"GO:0060490":1,"GO:0048496":1,"GO:0090210":1,"GO:0010579":1,"GO:0016525":1,"GO:2000852":1,"GO:0001764":1,"GO:0036515":1,"GO:0048105":1,"GO:0060732":1,"GO:0043129":1,"GO:0045176":1,"GO:0007189":1,"GO:0042249":1,"GO:0007413":1,"GO:0043031":1,"GO:0060347":1,"GO:0099558":1,"GO:0060133":1,"GO:0060124":1,"GO:0070528":1,"GO:0021796":1,"GO:0048469":1,"GO:0042220":1,"GO:0007204":1,"GO:0002076":1,"GO:0051965":1,"GO:1904938":1,"GO:0060488":1,"GO:0001525":1,"GO:1900747":1,"GO:0060489":1,"GO:0035025":1,"GO:0007266":1,"GO:0036514":1,"GO:0007156":1,"GO:0021801":1,"GO:2001223":1,"GO:0061743":1,"GO:0071329":1,"GO:0030252":1,"GO:0007200":1,"GO:0022011":1,"GO:0045777":1,"GO:0090179":1,"GO:0021819":1,"GO:0090251":1,"GO:1901223":1,"GO:0010573":1,"GO:0032792":1,"GO:0022900":1},"recipe_readded":[]}