{"hash":"156830877387358054","title":"Redox homeostasis and transcription regulation","description":"These proteins show strong enrichment for oxidation-reduction and redox homeostasis terms, plus cellular oxidant detoxification and protein repair, suggesting a core role in maintaining redox balance and repairing oxidative damage. The presence of DNA-templated transcription and transcription regulation terms indicates nuclear regulatory functions that may be modulated by redox state. Together, the cluster appears to couple redox maintenance with transcriptional control and protein maintenance activities.","confidence":"Medium","size":22,"edges":154,"triangles":609,"max_degree":21,"top_function":"DNA-templated transcription","members":[{"accession":"XP_790088.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0007601","GO:2000059","GO:1902605","GO:0001938","GO:0061084","GO:0007329","GO:0008616"]},{"accession":"XP_799253.2","go_terms":["GO:0007601","GO:2000059","GO:1902605","GO:0001938","GO:0061084","GO:0007329","GO:0008616"]},{"accession":"XP_011677706.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0000245","GO:0000398","GO:0051301","GO:0000278"]},{"accession":"XP_030854630.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]},{"accession":"XP_782876.3","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]},{"accession":"XP_030829735.1","go_terms":["GO:0007601","GO:2000059","GO:1902605","GO:0001938","GO:0061084","GO:0007329","GO:0008616"]},{"accession":"XP_030853449.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0006879","GO:0045041","GO:0016242"]},{"accession":"XP_789080.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]},{"accession":"XP_786407.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:1902376","GO:0036129","GO:0017004","GO:0072358","GO:0045494","GO:0010196"]},{"accession":"XP_791945.2","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:2001238","GO:0006621","GO:0051258","GO:0002027","GO:0007029","GO:0071313","GO:0060306","GO:1901017","GO:0014894","GO:0060315","GO:0045214","GO:0051208","GO:0010881","GO:0010649","GO:0060048","GO:0014809"]},{"accession":"XP_030847860.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0006878","GO:0008535","GO:0006825","GO:0007308","GO:0017004","GO:0072358","GO:0045494","GO:0010196","GO:0042158","GO:0008584","GO:0042744","GO:0007252","GO:0034101","GO:0018171","GO:0070301","GO:2000255","GO:0032872","GO:0007283","GO:0030416","GO:0042345","GO:0042267","GO:0019471","GO:0022417","GO:0019430","GO:0030198"]},{"accession":"XP_030847839.1","go_terms":["GO:0006885","GO:0045454","GO:0030420","GO:0071236","GO:0009411","GO:1901170","GO:0006749","GO:0030855","GO:0055114"]},{"accession":"XP_787642.1","go_terms":["GO:0098869","GO:0033209"]},{"accession":"XP_003725885.1","go_terms":["GO:0006885","GO:0045454","GO:0030420","GO:0071236","GO:0009411","GO:1901170","GO:0006749","GO:0030855","GO:0055114"]},{"accession":"XP_003731415.2","go_terms":["GO:0006885","GO:0045454","GO:0030420","GO:0071236","GO:0009411","GO:1901170","GO:0006749","GO:0030855","GO:0055114"]},{"accession":"XP_030831960.1","go_terms":["GO:1990355","GO:0070301","GO:0006464","GO:0055114","GO:0030091"]},{"accession":"XP_030844733.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0017004"]},{"accession":"XP_030831454.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:2001238","GO:0006621"]},{"accession":"XP_030846980.1","go_terms":["GO:0006885","GO:0045454","GO:0030420","GO:0071236","GO:0009411","GO:1901170","GO:0006749","GO:0030855","GO:0055114"]},{"accession":"XP_030847161.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0017004","GO:0042775","GO:0072358","GO:0045494","GO:0010196","GO:0042158","GO:0008584","GO:0042744","GO:0007252","GO:0034101","GO:0018171","GO:0070301","GO:2000255","GO:0032872","GO:0007283","GO:0030416","GO:0042345","GO:0042267","GO:0019471","GO:0022417","GO:0019430","GO:0030198"]},{"accession":"XP_781174.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0017004","GO:0072358","GO:0045494","GO:0010196","GO:0042158","GO:0008584","GO:0042744","GO:0007252","GO:0034101","GO:0018171","GO:0070301","GO:2000255","GO:0032872","GO:0007283","GO:0030416","GO:0042345","GO:0042267","GO:0019471","GO:0022417","GO:0019430","GO:0030198"]},{"accession":"XP_030847277.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091"]}],"graph":[["XP_799253.2","XP_030829735.1",0.53],["XP_799253.2","XP_030831454.1",0.673],["XP_799253.2","XP_030844733.1",0.62],["XP_799253.2","XP_030847161.1",0.772],["XP_799253.2","XP_030847277.1",0.546],["XP_799253.2","XP_030847839.1",0.52],["XP_799253.2","XP_030847860.1",0.726],["XP_799253.2","XP_030854630.1",0.821],["XP_799253.2","XP_781174.1",0.716],["XP_799253.2","XP_782876.3",0.75],["XP_799253.2","XP_786407.1",0.533],["XP_799253.2","XP_787642.1",0.627],["XP_799253.2","XP_789080.1",0.765],["XP_799253.2","XP_790088.1",0.769],["XP_799253.2","XP_791945.2",0.663],["XP_799253.2","XP_003725885.1",0.521],["XP_799253.2","XP_003731415.2",0.523],["XP_799253.2","XP_011677706.1",0.712],["XP_789080.1","XP_030829735.1",0.657],["XP_789080.1","XP_030831454.1",0.724],["XP_789080.1","XP_030844733.1",0.627],["XP_789080.1","XP_030846980.1",0.61],["XP_789080.1","XP_030847161.1",0.723],["XP_789080.1","XP_030847839.1",0.614],["XP_789080.1","XP_030847860.1",0.79],["XP_789080.1","XP_030853449.1",0.686],["XP_789080.1","XP_030854630.1",0.535],["XP_789080.1","XP_781174.1",0.556],["XP_789080.1","XP_782876.3",0.696],["XP_789080.1","XP_786407.1",0.581],["XP_789080.1","XP_787642.1",0.676],["XP_789080.1","XP_790088.1",0.613],["XP_789080.1","XP_791945.2",0.728],["XP_789080.1","XP_003725885.1",0.521],["XP_789080.1","XP_003731415.2",0.52],["XP_789080.1","XP_011677706.1",0.634],["XP_030846980.1","XP_030844733.1",0.576],["XP_030846980.1","XP_030847161.1",0.549],["XP_030846980.1","XP_030847860.1",0.587],["XP_030846980.1","XP_781174.1",0.505],["XP_030846980.1","XP_782876.3",0.553],["XP_786407.1","XP_030829735.1",0.694],["XP_786407.1","XP_030831454.1",0.668],["XP_786407.1","XP_030831960.1",0.572],["XP_786407.1","XP_030844733.1",0.512],["XP_786407.1","XP_030847161.1",0.785],["XP_786407.1","XP_030847860.1",0.614],["XP_786407.1","XP_030853449.1",0.689],["XP_786407.1","XP_030854630.1",0.862],["XP_786407.1","XP_781174.1",0.59],["XP_786407.1","XP_782876.3",0.638],["XP_786407.1","XP_787642.1",0.696],["XP_786407.1","XP_790088.1",0.55],["XP_786407.1","XP_791945.2",0.606],["XP_786407.1","XP_011677706.1",0.734],["XP_030847161.1","XP_030844733.1",0.719],["XP_030847161.1","XP_030847860.1",0.795],["XP_030847161.1","XP_791945.2",0.814],["XP_030847161.1","XP_787642.1",0.608],["XP_030847161.1","XP_790088.1",0.681],["XP_030847161.1","XP_781174.1",0.769],["XP_030847161.1","XP_782876.3",0.734],["XP_030847161.1","XP_030854630.1",0.613],["XP_030847161.1","XP_030853449.1",0.72],["XP_030847161.1","XP_003725885.1",0.568],["XP_030847161.1","XP_003731415.2",0.509],["XP_030847161.1","XP_011677706.1",0.63],["XP_030847161.1","XP_030829735.1",0.677],["XP_030847161.1","XP_030831454.1",0.792],["XP_030847161.1","XP_030831960.1",0.57],["XP_782876.3","XP_030829735.1",0.741],["XP_782876.3","XP_030831454.1",0.684],["XP_782876.3","XP_030844733.1",0.833],["XP_782876.3","XP_030847277.1",0.547],["XP_782876.3","XP_030847839.1",0.608],["XP_782876.3","XP_030847860.1",0.736],["XP_782876.3","XP_030853449.1",0.705],["XP_782876.3","XP_030854630.1",0.677],["XP_782876.3","XP_791945.2",0.64],["XP_782876.3","XP_787642.1",0.881],["XP_782876.3","XP_790088.1",0.734],["XP_782876.3","XP_781174.1",0.729],["XP_782876.3","XP_003725885.1",0.587],["XP_782876.3","XP_003731415.2",0.675],["XP_782876.3","XP_011677706.1",0.744],["XP_011677706.1","XP_030829735.1",0.663],["XP_011677706.1","XP_030831454.1",0.625],["XP_011677706.1","XP_030844733.1",0.504],["XP_011677706.1","XP_030847860.1",0.673],["XP_011677706.1","XP_030853449.1",0.569],["XP_011677706.1","XP_781174.1",0.61],["XP_011677706.1","XP_790088.1",0.623],["XP_011677706.1","XP_791945.2",0.645],["XP_030853449.1","XP_030831454.1",0.747],["XP_030853449.1","XP_030844733.1",0.621],["XP_030853449.1","XP_030847277.1",0.538],["XP_030853449.1","XP_030847860.1",0.764],["XP_030853449.1","XP_030854630.1",0.656],["XP_030853449.1","XP_781174.1",0.551],["XP_030853449.1","XP_787642.1",0.665],["XP_030853449.1","XP_790088.1",0.644],["XP_030853449.1","XP_791945.2",0.765],["XP_030847277.1","XP_030847860.1",0.58],["XP_030847277.1","XP_787642.1",0.611],["XP_030847277.1","XP_030854630.1",0.511],["XP_030847277.1","XP_030831454.1",0.557],["XP_030847860.1","XP_030844733.1",0.63],["XP_030847860.1","XP_030847839.1",0.534],["XP_030847860.1","XP_030854630.1",0.705],["XP_030847860.1","XP_781174.1",0.673],["XP_030847860.1","XP_787642.1",0.831],["XP_030847860.1","XP_790088.1",0.602],["XP_030847860.1","XP_791945.2",0.781],["XP_030847860.1","XP_003725885.1",0.504],["XP_030847860.1","XP_003731415.2",0.535],["XP_030847860.1","XP_030829735.1",0.701],["XP_030847860.1","XP_030831454.1",0.797],["XP_030847860.1","XP_030831960.1",0.546],["XP_030831454.1","XP_791945.2",0.761],["XP_030831454.1","XP_787642.1",0.75],["XP_030831454.1","XP_790088.1",0.691],["XP_030831454.1","XP_781174.1",0.684],["XP_030831454.1","XP_030854630.1",0.729],["XP_030831454.1","XP_003731415.2",0.531],["XP_030831454.1","XP_030829735.1",0.767],["XP_030831454.1","XP_030844733.1",0.698],["XP_781174.1","XP_030829735.1",0.681],["XP_781174.1","XP_030844733.1",0.56],["XP_781174.1","XP_030847839.1",0.584],["XP_781174.1","XP_791945.2",0.703],["XP_781174.1","XP_787642.1",0.695],["XP_781174.1","XP_790088.1",0.69],["XP_781174.1","XP_003725885.1",0.509],["XP_781174.1","XP_003731415.2",0.555],["XP_030844733.1","XP_030854630.1",0.665],["XP_030844733.1","XP_787642.1",0.726],["XP_030844733.1","XP_790088.1",0.748],["XP_030844733.1","XP_791945.2",0.803],["XP_030844733.1","XP_003731415.2",0.511],["XP_030844733.1","XP_030829735.1",0.528],["XP_787642.1","XP_030829735.1",0.741],["XP_787642.1","XP_030854630.1",0.828],["XP_787642.1","XP_790088.1",0.743],["XP_787642.1","XP_791945.2",0.67],["XP_791945.2","XP_030829735.1",0.687],["XP_791945.2","XP_030854630.1",0.769],["XP_791945.2","XP_790088.1",0.577],["XP_003725885.1","XP_030847839.1",0.513],["XP_003725885.1","XP_790088.1",0.511],["XP_790088.1","XP_030829735.1",0.633],["XP_790088.1","XP_030847839.1",0.515],["XP_790088.1","XP_030854630.1",0.707],["XP_790088.1","XP_003731415.2",0.562],["XP_030829735.1","XP_030854630.1",0.744]],"all_go_terms":{"GO:0006351":14,"GO:2000059":3,"GO:0018401":14,"GO:0043388":14,"GO:0000122":14,"GO:0046826":14,"GO:0006662":14,"GO:0033158":14,"GO:0034976":14,"GO:0055114":19,"GO:0061084":3,"GO:0034599":14,"GO:1903206":14,"GO:0098869":15,"GO:0034975":14,"GO:0001938":3,"GO:0030091":15,"GO:0008616":3,"GO:0080058":14,"GO:0016032":14,"GO:1902605":3,"GO:0007329":3,"GO:0045454":18,"GO:0007601":3,"GO:1903026":14,"GO:0000278":1,"GO:0000398":1,"GO:0051301":1,"GO:0000245":1,"GO:0045041":1,"GO:0016242":1,"GO:0006879":1,"GO:0072358":4,"GO:1902376":1,"GO:0017004":5,"GO:0010196":4,"GO:0036129":1,"GO:0045494":4,"GO:0071313":1,"GO:0060048":1,"GO:0002027":1,"GO:0051258":1,"GO:1901017":1,"GO:0045214":1,"GO:2001238":2,"GO:0010649":1,"GO:0060306":1,"GO:0006621":2,"GO:0010881":1,"GO:0060315":1,"GO:0014894":1,"GO:0014809":1,"GO:0007029":1,"GO:0051208":1,"GO:0032872":3,"GO:0008584":3,"GO:0008535":1,"GO:0007308":1,"GO:0030416":3,"GO:0042267":3,"GO:0007283":3,"GO:0019471":3,"GO:0042158":3,"GO:0018171":3,"GO:0006878":1,"GO:2000255":3,"GO:0042345":3,"GO:0034101":3,"GO:0030198":3,"GO:0006825":1,"GO:0070301":4,"GO:0042744":3,"GO:0022417":3,"GO:0019430":3,"GO:0007252":3,"GO:1901170":4,"GO:0006885":4,"GO:0006749":4,"GO:0030855":4,"GO:0071236":4,"GO:0030420":4,"GO:0009411":4,"GO:0033209":1,"GO:0006464":1,"GO:1990355":1,"GO:0042775":1},"recipe_readded":[]}