{"hash":"1263264254740229727","title":"ER stress-induced mitochondrial apoptosis","description":"The top GO terms cluster around mitochondrial function and stress- and apoptosis-related processes: intrinsic apoptotic signaling in response to ER stress, regulation of mitochondrial membrane potential and permeability, glutathione catabolism (redox balance), and ubiquinone biosynthesis (mitochondrial electron transport). A couple of terms about development (face morphogenesis, mammary duct growth) may be incidental. Overall, the dominant theme is mitochondria-mediated responses to cellular stress leading to apoptosis, justifying the name.","confidence":"Medium","size":14,"edges":17,"triangles":2,"max_degree":4,"top_function":null,"members":[{"accession":"XP_030830830.1","go_terms":[]},{"accession":"XP_030831963.1","go_terms":[]},{"accession":"XP_030842317.1","go_terms":[]},{"accession":"XP_030844028.1","go_terms":[]},{"accession":"XP_030853052.1","go_terms":["GO:0006744"]},{"accession":"XP_003728923.2","go_terms":["GO:0035794","GO:0010917","GO:0010940"]},{"accession":"XP_030851247.1","go_terms":[]},{"accession":"XP_781155.3","go_terms":["GO:0045746","GO:0006751","GO:0070059"]},{"accession":"XP_030853373.1","go_terms":["GO:0060325"]},{"accession":"XP_030855524.1","go_terms":["GO:0045746","GO:0006751","GO:0070059"]},{"accession":"XP_030835765.1","go_terms":["GO:0006796"]},{"accession":"XP_030841850.1","go_terms":["GO:1902042","GO:0007596","GO:0090201","GO:0048771","GO:0003383","GO:0045445","GO:0051450","GO:0052182","GO:0031639","GO:1901299","GO:0016476","GO:0022617","GO:0051918","GO:0051919","GO:0033601","GO:0060707","GO:1903133","GO:0007155","GO:0060665","GO:0060763","GO:0048012","GO:0042730","GO:0033137","GO:0071674","GO:0032715","GO:1902947","GO:0035729","GO:1900744","GO:0010758","GO:0032733","GO:0048544"]},{"accession":"XP_030845205.1","go_terms":["GO:0002853","GO:0032836","GO:0035889","GO:0090528","GO:0007160","GO:0007605"]},{"accession":"XP_030828191.1","go_terms":[]}],"graph":[["XP_030855524.1","XP_030835765.1",0.615],["XP_030855524.1","XP_030845205.1",0.6],["XP_030855524.1","XP_030853373.1",0.585],["XP_030855524.1","XP_781155.3",0.725],["XP_030831963.1","XP_030853373.1",0.507],["XP_030831963.1","XP_030842317.1",0.513],["XP_030845205.1","XP_781155.3",0.528],["XP_030845205.1","XP_030828191.1",0.6],["XP_030842317.1","XP_030844028.1",0.674],["XP_030842317.1","XP_030853052.1",0.597],["XP_030842317.1","XP_030830830.1",0.511],["XP_030844028.1","XP_030835765.1",0.512],["XP_030844028.1","XP_003728923.2",0.576],["XP_781155.3","XP_030835765.1",0.612],["XP_030841850.1","XP_030853052.1",0.55],["XP_030830830.1","XP_030828191.1",0.507],["XP_030853052.1","XP_030828191.1",0.728]],"all_go_terms":{"GO:0006744":1,"GO:0010940":1,"GO:0010917":1,"GO:0035794":1,"GO:0006751":2,"GO:0045746":2,"GO:0070059":2,"GO:0060325":1,"GO:0006796":1,"GO:0060763":1,"GO:0003383":1,"GO:0048012":1,"GO:0051919":1,"GO:0071674":1,"GO:0033137":1,"GO:1902947":1,"GO:1903133":1,"GO:0048544":1,"GO:0035729":1,"GO:0045445":1,"GO:1900744":1,"GO:0016476":1,"GO:1902042":1,"GO:0048771":1,"GO:0031639":1,"GO:0032733":1,"GO:0033601":1,"GO:0007155":1,"GO:0090201":1,"GO:0010758":1,"GO:0022617":1,"GO:0007596":1,"GO:0051450":1,"GO:0060665":1,"GO:0060707":1,"GO:0051918":1,"GO:0042730":1,"GO:0052182":1,"GO:0032715":1,"GO:1901299":1,"GO:0002853":1,"GO:0007160":1,"GO:0035889":1,"GO:0090528":1,"GO:0007605":1,"GO:0032836":1},"recipe_readded":[]}