{"hash":"1043067353068068690","title":"Receptor trafficking and lysosomal localization","description":"The top GO terms point to receptor signaling at the cell surface (cell surface receptor signaling, integrin-related signaling, regulation of cell motility) together with intracellular trafficking that routes receptors via endosomes to lysosomes (receptor internalization, endosome-to-melanosome transport, protein localization to lysosome, lysosomal degradation). This suggests a coherent theme of receptors coordinating signaling with endocytic trafficking and lysosomal targeting, with migration-related processes linked to adhesion signaling. High","confidence":"","size":21,"edges":183,"triangles":940,"max_degree":20,"top_function":null,"members":[{"accession":"XP_787272.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_003725684.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_794304.3","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030839880.1","go_terms":["GO:1903169","GO:0060005","GO:0060117","GO:0050910","GO:1902041","GO:0055069","GO:0032460"]},{"accession":"XP_030845092.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030837716.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030844774.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030845232.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030845233.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030845883.1","go_terms":[]},{"accession":"XP_782194.1","go_terms":["GO:0035151","GO:0019991","GO:0070588","GO:0070296","GO:0060857","GO:0045671","GO:0034765","GO:0060088","GO:0050910"]},{"accession":"XP_787025.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_787729.3","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_798693.2","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_003728524.2","go_terms":["GO:2001212","GO:0019226","GO:0019227","GO:0070830","GO:0016338","GO:0050806","GO:0051899","GO:0061772","GO:0061436","GO:0001765","GO:0031174","GO:0009253","GO:0060081","GO:0008219","GO:0097202","GO:0016049","GO:0071805","GO:0071847","GO:0003093","GO:0034394","GO:0045022","GO:0035725","GO:0032060","GO:0060992","GO:2000311","GO:0010226","GO:2001205","GO:0097186","GO:0019076","GO:0035235","GO:2001046","GO:1903348","GO:0051291","GO:0007528","GO:0043534","GO:0098943","GO:0060079","GO:1903545","GO:0070252","GO:0045779","GO:0007566","GO:0001954","GO:0070588","GO:0099590","GO:0001913","GO:0098970","GO:0051966","GO:0043297","GO:0016998","GO:0060088","GO:0050910"]},{"accession":"XP_003729276.1","go_terms":[]},{"accession":"XP_030845406.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030856195.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_011664079.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_030851019.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]},{"accession":"XP_788310.1","go_terms":["GO:0030886","GO:1901223","GO:0007166","GO:0030913","GO:0046813","GO:0045747","GO:0043128","GO:0014005","GO:0035646","GO:2001046","GO:0007601","GO:1904352","GO:0061462","GO:0060219","GO:2000680","GO:0061298","GO:0031623","GO:0071404","GO:0090528","GO:2000145","GO:1900746"]}],"graph":[["XP_030839880.1","XP_030844774.1",0.576],["XP_030839880.1","XP_030851019.1",0.507],["XP_030839880.1","XP_030856195.1",0.591],["XP_030839880.1","XP_782194.1",0.573],["XP_030839880.1","XP_787272.1",0.672],["XP_030839880.1","XP_787729.3",0.536],["XP_030839880.1","XP_788310.1",0.755],["XP_030839880.1","XP_794304.3",0.65],["XP_030839880.1","XP_798693.2",0.558],["XP_030839880.1","XP_003725684.1",0.502],["XP_030839880.1","XP_003729276.1",0.521],["XP_030839880.1","XP_011664079.1",0.629],["XP_030839880.1","XP_030837716.1",0.52],["XP_798693.2","XP_030837716.1",0.776],["XP_798693.2","XP_030844774.1",0.782],["XP_798693.2","XP_030845092.1",0.788],["XP_798693.2","XP_030845232.1",0.805],["XP_798693.2","XP_030845233.1",0.801],["XP_798693.2","XP_030845406.1",0.797],["XP_798693.2","XP_030851019.1",0.822],["XP_798693.2","XP_030856195.1",0.82],["XP_798693.2","XP_782194.1",0.556],["XP_798693.2","XP_787025.1",0.781],["XP_798693.2","XP_787272.1",0.803],["XP_798693.2","XP_787729.3",0.745],["XP_798693.2","XP_788310.1",0.797],["XP_798693.2","XP_794304.3",0.823],["XP_798693.2","XP_003725684.1",0.834],["XP_798693.2","XP_003728524.2",0.791],["XP_798693.2","XP_011664079.1",0.814],["XP_030845232.1","XP_030837716.1",0.802],["XP_030845232.1","XP_030844774.1",0.814],["XP_030845232.1","XP_030845092.1",0.782],["XP_030845232.1","XP_030845233.1",0.838],["XP_030845232.1","XP_030845406.1",0.797],["XP_030845232.1","XP_030845883.1",0.507],["XP_030845232.1","XP_030851019.1",0.823],["XP_030845232.1","XP_030856195.1",0.851],["XP_030845232.1","XP_782194.1",0.677],["XP_030845232.1","XP_787025.1",0.788],["XP_030845232.1","XP_787272.1",0.829],["XP_030845232.1","XP_787729.3",0.763],["XP_030845232.1","XP_788310.1",0.82],["XP_030845232.1","XP_794304.3",0.836],["XP_030845232.1","XP_003725684.1",0.861],["XP_030845232.1","XP_003728524.2",0.732],["XP_030845232.1","XP_003729276.1",0.69],["XP_030845232.1","XP_011664079.1",0.762],["XP_030845406.1","XP_030837716.1",0.797],["XP_030845406.1","XP_030844774.1",0.803],["XP_030845406.1","XP_030845092.1",0.778],["XP_030845406.1","XP_030845233.1",0.805],["XP_030845406.1","XP_030851019.1",0.816],["XP_030845406.1","XP_030856195.1",0.742],["XP_030845406.1","XP_782194.1",0.584],["XP_030845406.1","XP_787025.1",0.713],["XP_030845406.1","XP_787272.1",0.819],["XP_030845406.1","XP_787729.3",0.812],["XP_030845406.1","XP_788310.1",0.774],["XP_030845406.1","XP_794304.3",0.824],["XP_030845406.1","XP_003725684.1",0.828],["XP_030845406.1","XP_003728524.2",0.646],["XP_030845406.1","XP_011664079.1",0.768],["XP_794304.3","XP_030837716.1",0.802],["XP_794304.3","XP_030844774.1",0.834],["XP_794304.3","XP_030845092.1",0.758],["XP_794304.3","XP_030845233.1",0.834],["XP_794304.3","XP_030851019.1",0.836],["XP_794304.3","XP_030856195.1",0.775],["XP_794304.3","XP_782194.1",0.633],["XP_794304.3","XP_787025.1",0.803],["XP_794304.3","XP_787272.1",0.866],["XP_794304.3","XP_787729.3",0.809],["XP_794304.3","XP_788310.1",0.833],["XP_794304.3","XP_003725684.1",0.853],["XP_794304.3","XP_003728524.2",0.57],["XP_794304.3","XP_003729276.1",0.536],["XP_794304.3","XP_011664079.1",0.79],["XP_030856195.1","XP_030837716.1",0.845],["XP_030856195.1","XP_030844774.1",0.859],["XP_030856195.1","XP_030845092.1",0.77],["XP_030856195.1","XP_030845233.1",0.861],["XP_030856195.1","XP_030851019.1",0.858],["XP_030856195.1","XP_787025.1",0.836],["XP_030856195.1","XP_787272.1",0.77],["XP_030856195.1","XP_787729.3",0.805],["XP_030856195.1","XP_788310.1",0.807],["XP_030856195.1","XP_003725684.1",0.868],["XP_030856195.1","XP_003728524.2",0.63],["XP_030856195.1","XP_011664079.1",0.836],["XP_787025.1","XP_030837716.1",0.793],["XP_787025.1","XP_030844774.1",0.832],["XP_787025.1","XP_030845092.1",0.802],["XP_787025.1","XP_030845233.1",0.81],["XP_787025.1","XP_030845883.1",0.559],["XP_787025.1","XP_030851019.1",0.784],["XP_787025.1","XP_782194.1",0.661],["XP_787025.1","XP_787272.1",0.788],["XP_787025.1","XP_787729.3",0.771],["XP_787025.1","XP_788310.1",0.776],["XP_787025.1","XP_003725684.1",0.829],["XP_787025.1","XP_003728524.2",0.633],["XP_787025.1","XP_003729276.1",0.528],["XP_787025.1","XP_011664079.1",0.748],["XP_011664079.1","XP_003725684.1",0.792],["XP_011664079.1","XP_003728524.2",0.776],["XP_011664079.1","XP_003729276.1",0.663],["XP_011664079.1","XP_030837716.1",0.814],["XP_011664079.1","XP_030844774.1",0.814],["XP_011664079.1","XP_030845092.1",0.716],["XP_011664079.1","XP_030845233.1",0.77],["XP_011664079.1","XP_030845883.1",0.553],["XP_011664079.1","XP_030851019.1",0.793],["XP_011664079.1","XP_782194.1",0.623],["XP_011664079.1","XP_787272.1",0.792],["XP_011664079.1","XP_787729.3",0.811],["XP_011664079.1","XP_788310.1",0.817],["XP_003728524.2","XP_003725684.1",0.693],["XP_003728524.2","XP_003729276.1",0.695],["XP_003728524.2","XP_030837716.1",0.628],["XP_003728524.2","XP_030845883.1",0.65],["XP_003728524.2","XP_030844774.1",0.636],["XP_003728524.2","XP_030845092.1",0.534],["XP_003728524.2","XP_030845233.1",0.649],["XP_003728524.2","XP_787272.1",0.64],["XP_003728524.2","XP_787729.3",0.6],["XP_003728524.2","XP_788310.1",0.61],["XP_003728524.2","XP_782194.1",0.724],["XP_003728524.2","XP_030851019.1",0.601],["XP_003729276.1","XP_030837716.1",0.501],["XP_003729276.1","XP_030845883.1",0.567],["XP_003729276.1","XP_030845092.1",0.519],["XP_003729276.1","XP_030845233.1",0.629],["XP_003729276.1","XP_787272.1",0.742],["XP_003729276.1","XP_787729.3",0.502],["XP_003729276.1","XP_788310.1",0.557],["XP_003729276.1","XP_782194.1",0.504],["XP_003729276.1","XP_030851019.1",0.534],["XP_003725684.1","XP_030837716.1",0.836],["XP_003725684.1","XP_030844774.1",0.806],["XP_003725684.1","XP_030845092.1",0.784],["XP_003725684.1","XP_030845233.1",0.834],["XP_003725684.1","XP_030851019.1",0.829],["XP_003725684.1","XP_782194.1",0.592],["XP_003725684.1","XP_787272.1",0.799],["XP_003725684.1","XP_787729.3",0.76],["XP_003725684.1","XP_788310.1",0.833],["XP_788310.1","XP_030837716.1",0.802],["XP_788310.1","XP_030844774.1",0.787],["XP_788310.1","XP_030845092.1",0.768],["XP_788310.1","XP_030845233.1",0.765],["XP_788310.1","XP_030845883.1",0.623],["XP_788310.1","XP_030851019.1",0.826],["XP_788310.1","XP_782194.1",0.618],["XP_788310.1","XP_787272.1",0.837],["XP_788310.1","XP_787729.3",0.73],["XP_030845233.1","XP_030837716.1",0.831],["XP_030845233.1","XP_030844774.1",0.829],["XP_030845233.1","XP_030845092.1",0.76],["XP_030845233.1","XP_030851019.1",0.814],["XP_030845233.1","XP_782194.1",0.727],["XP_030845233.1","XP_787272.1",0.825],["XP_030845233.1","XP_787729.3",0.761],["XP_030845883.1","XP_787272.1",0.752],["XP_030851019.1","XP_030837716.1",0.782],["XP_030851019.1","XP_030844774.1",0.796],["XP_030851019.1","XP_030845092.1",0.79],["XP_030851019.1","XP_782194.1",0.676],["XP_030851019.1","XP_787272.1",0.822],["XP_030851019.1","XP_787729.3",0.798],["XP_782194.1","XP_030837716.1",0.506],["XP_782194.1","XP_030844774.1",0.669],["XP_782194.1","XP_787272.1",0.572],["XP_787272.1","XP_030837716.1",0.781],["XP_787272.1","XP_030844774.1",0.812],["XP_787272.1","XP_030845092.1",0.786],["XP_787272.1","XP_787729.3",0.721],["XP_030845092.1","XP_030837716.1",0.762],["XP_030845092.1","XP_030844774.1",0.813],["XP_030845092.1","XP_787729.3",0.735],["XP_787729.3","XP_030837716.1",0.781],["XP_787729.3","XP_030844774.1",0.779],["XP_030844774.1","XP_030837716.1",0.814]],"all_go_terms":{"GO:2000145":16,"GO:0030886":16,"GO:0030913":16,"GO:0035646":16,"GO:0043128":16,"GO:0031623":16,"GO:1904352":16,"GO:0061462":16,"GO:0007166":16,"GO:2000680":16,"GO:0090528":16,"GO:0060219":16,"GO:2001046":17,"GO:0014005":16,"GO:0061298":16,"GO:0045747":16,"GO:0046813":16,"GO:1901223":16,"GO:1900746":16,"GO:0007601":16,"GO:0071404":16,"GO:1902041":1,"GO:0060005":1,"GO:0055069":1,"GO:1903169":1,"GO:0032460":1,"GO:0060117":1,"GO:0050910":3,"GO:0060088":2,"GO:0060857":1,"GO:0034765":1,"GO:0035151":1,"GO:0070296":1,"GO:0045671":1,"GO:0070588":2,"GO:0019991":1,"GO:0031174":1,"GO:0034394":1,"GO:0010226":1,"GO:0097202":1,"GO:0060079":1,"GO:0016998":1,"GO:0016049":1,"GO:0019227":1,"GO:0071805":1,"GO:0043534":1,"GO:0051291":1,"GO:0060081":1,"GO:2001205":1,"GO:0097186":1,"GO:0060992":1,"GO:0019076":1,"GO:0035725":1,"GO:0001913":1,"GO:0007528":1,"GO:1903545":1,"GO:0032060":1,"GO:0003093":1,"GO:0050806":1,"GO:1903348":1,"GO:0001954":1,"GO:0008219":1,"GO:0098943":1,"GO:0099590":1,"GO:0070830":1,"GO:0035235":1,"GO:0019226":1,"GO:0071847":1,"GO:2001212":1,"GO:0051966":1,"GO:0061436":1,"GO:0045022":1,"GO:0045779":1,"GO:0001765":1,"GO:0070252":1,"GO:0009253":1,"GO:0098970":1,"GO:0007566":1,"GO:2000311":1,"GO:0061772":1,"GO:0043297":1,"GO:0016338":1,"GO:0051899":1},"recipe_readded":[]}