{"hash":"90493822622846229","title":"Bone Formation and Remodeling","description":"The cluster shows strong enrichment for bone-related processes: intramembranous ossification and bone resorption directly point to skeletal remodeling, while Wnt signaling regulation is a central driver of osteogenesis. Additional terms like thyroid hormone response and regulation of catalytic activity can modulate bone metabolism, supporting a cohesive theme around bone development and remodeling. Some terms (e.g., decidualization, T cell cytotoxicity) are more peripheral but do not outweigh the dominant bone biology signal.","confidence":"High","size":18,"edges":133,"triangles":570,"max_degree":17,"top_function":null,"members":[{"accession":"NP_563648.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"NP_567686.2","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_195406.2","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"NP_565649.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"NP_564497.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_566633.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_566867.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_567983.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_680113.3","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_563647.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"NP_563764.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"NP_563855.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"NP_566901.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]},{"accession":"NP_567010.5","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_567215.1","go_terms":["GO:0097067","GO:0050790","GO:0030574","GO:0006508","GO:0046697","GO:0051603","GO:0001957","GO:0010815","GO:0010813","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0045453","GO:0035593"]},{"accession":"NP_567376.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_568052.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593"]},{"accession":"NP_568722.1","go_terms":["GO:0007614","GO:0034769","GO:0097067","GO:0071888","GO:0043129","GO:0060448","GO:0010813","GO:0010815","GO:1903955","GO:0045453","GO:0010839","GO:0051603","GO:0001957","GO:0030574","GO:0001913","GO:1903146","GO:0050790","GO:2000179","GO:0060441","GO:0046697","GO:0035593","GO:0009636","GO:0042493","GO:1990236","GO:1990237","GO:0043418","GO:0006508"]}],"graph":[["NP_568722.1","NP_195406.2",0.736],["NP_568722.1","NP_563647.1",0.561],["NP_568722.1","NP_563764.1",0.745],["NP_568722.1","NP_563855.1",0.654],["NP_568722.1","NP_564497.1",0.734],["NP_568722.1","NP_565649.1",0.728],["NP_568722.1","NP_566633.1",0.548],["NP_568722.1","NP_566867.1",0.731],["NP_568722.1","NP_566901.1",0.546],["NP_568722.1","NP_567010.5",0.846],["NP_568722.1","NP_567215.1",0.511],["NP_568722.1","NP_567376.1",0.68],["NP_568722.1","NP_567686.2",0.795],["NP_568722.1","NP_567983.1",0.718],["NP_568722.1","NP_568052.1",0.68],["NP_568722.1","NP_680113.3",0.717],["NP_680113.3","NP_195406.2",0.836],["NP_680113.3","NP_563647.1",0.656],["NP_680113.3","NP_563648.1",0.698],["NP_680113.3","NP_563764.1",0.728],["NP_680113.3","NP_563855.1",0.719],["NP_680113.3","NP_564497.1",0.778],["NP_680113.3","NP_565649.1",0.676],["NP_680113.3","NP_566633.1",0.773],["NP_680113.3","NP_566867.1",0.732],["NP_680113.3","NP_566901.1",0.629],["NP_680113.3","NP_567010.5",0.789],["NP_680113.3","NP_567215.1",0.717],["NP_680113.3","NP_567376.1",0.8],["NP_680113.3","NP_567686.2",0.793],["NP_680113.3","NP_567983.1",0.885],["NP_680113.3","NP_568052.1",0.824],["NP_563647.1","NP_563764.1",0.596],["NP_563647.1","NP_568052.1",0.645],["NP_563647.1","NP_567376.1",0.56],["NP_563647.1","NP_567686.2",0.558],["NP_563647.1","NP_567010.5",0.736],["NP_563647.1","NP_565649.1",0.501],["NP_567983.1","NP_195406.2",0.765],["NP_567983.1","NP_563648.1",0.603],["NP_567983.1","NP_563764.1",0.74],["NP_567983.1","NP_563855.1",0.696],["NP_567983.1","NP_564497.1",0.772],["NP_567983.1","NP_565649.1",0.745],["NP_567983.1","NP_566633.1",0.693],["NP_567983.1","NP_566867.1",0.639],["NP_567983.1","NP_566901.1",0.652],["NP_567983.1","NP_567010.5",0.776],["NP_567983.1","NP_567215.1",0.631],["NP_567983.1","NP_567376.1",0.76],["NP_567983.1","NP_567686.2",0.809],["NP_567983.1","NP_568052.1",0.724],["NP_563764.1","NP_195406.2",0.574],["NP_563764.1","NP_563855.1",0.705],["NP_563764.1","NP_568052.1",0.737],["NP_563764.1","NP_567215.1",0.584],["NP_563764.1","NP_567376.1",0.728],["NP_563764.1","NP_567686.2",0.737],["NP_563764.1","NP_566633.1",0.646],["NP_563764.1","NP_566867.1",0.661],["NP_563764.1","NP_566901.1",0.551],["NP_563764.1","NP_567010.5",0.706],["NP_563764.1","NP_565649.1",0.609],["NP_563764.1","NP_564497.1",0.678],["NP_567215.1","NP_195406.2",0.719],["NP_567215.1","NP_563855.1",0.716],["NP_567215.1","NP_564497.1",0.685],["NP_567215.1","NP_565649.1",0.515],["NP_567215.1","NP_566867.1",0.599],["NP_567215.1","NP_566901.1",0.573],["NP_567215.1","NP_567010.5",0.808],["NP_567215.1","NP_567376.1",0.663],["NP_567215.1","NP_567686.2",0.633],["NP_567215.1","NP_568052.1",0.582],["NP_566867.1","NP_195406.2",0.62],["NP_566867.1","NP_563855.1",0.658],["NP_566867.1","NP_564497.1",0.641],["NP_566867.1","NP_565649.1",0.623],["NP_566867.1","NP_568052.1",0.68],["NP_566867.1","NP_566633.1",0.542],["NP_566867.1","NP_566901.1",0.536],["NP_566867.1","NP_567010.5",0.526],["NP_566867.1","NP_567376.1",0.557],["NP_566867.1","NP_567686.2",0.641],["NP_567376.1","NP_195406.2",0.668],["NP_567376.1","NP_563648.1",0.637],["NP_567376.1","NP_563855.1",0.576],["NP_567376.1","NP_564497.1",0.801],["NP_567376.1","NP_565649.1",0.706],["NP_567376.1","NP_566633.1",0.742],["NP_567376.1","NP_566901.1",0.644],["NP_567376.1","NP_567010.5",0.731],["NP_567376.1","NP_567686.2",0.833],["NP_567376.1","NP_568052.1",0.681],["NP_566633.1","NP_195406.2",0.652],["NP_566633.1","NP_563648.1",0.593],["NP_566633.1","NP_563855.1",0.658],["NP_566633.1","NP_564497.1",0.683],["NP_566633.1","NP_565649.1",0.505],["NP_566633.1","NP_568052.1",0.524],["NP_566633.1","NP_567010.5",0.781],["NP_566633.1","NP_567686.2",0.669],["NP_563648.1","NP_195406.2",0.528],["NP_563648.1","NP_563855.1",0.504],["NP_563648.1","NP_568052.1",0.619],["NP_563648.1","NP_567686.2",0.616],["NP_563648.1","NP_567010.5",0.595],["NP_195406.2","NP_563855.1",0.707],["NP_195406.2","NP_568052.1",0.775],["NP_195406.2","NP_567686.2",0.763],["NP_195406.2","NP_566901.1",0.653],["NP_195406.2","NP_567010.5",0.75],["NP_195406.2","NP_565649.1",0.696],["NP_195406.2","NP_564497.1",0.785],["NP_567686.2","NP_563855.1",0.816],["NP_567686.2","NP_564497.1",0.665],["NP_567686.2","NP_565649.1",0.829],["NP_567686.2","NP_566901.1",0.644],["NP_567686.2","NP_567010.5",0.706],["NP_567686.2","NP_568052.1",0.836],["NP_564497.1","NP_563855.1",0.685],["NP_564497.1","NP_565649.1",0.63],["NP_564497.1","NP_566901.1",0.596],["NP_564497.1","NP_567010.5",0.743],["NP_564497.1","NP_568052.1",0.636],["NP_567010.5","NP_563855.1",0.788],["NP_567010.5","NP_568052.1",0.531],["NP_567010.5","NP_566901.1",0.739],["NP_568052.1","NP_563855.1",0.702],["NP_568052.1","NP_565649.1",0.59],["NP_568052.1","NP_566901.1",0.633],["NP_563855.1","NP_565649.1",0.586],["NP_563855.1","NP_566901.1",0.75]],"all_go_terms":{"GO:0046697":18,"GO:0035593":18,"GO:0050790":18,"GO:0001913":18,"GO:0097067":18,"GO:2000179":18,"GO:0010815":18,"GO:0001957":18,"GO:0045453":18,"GO:0051603":18,"GO:0006508":9,"GO:0030574":18,"GO:0010813":18,"GO:0034769":18,"GO:0060448":18,"GO:0060441":18,"GO:1903955":15,"GO:0007614":15,"GO:0010839":15,"GO:0071888":15,"GO:1903146":15,"GO:0043129":15,"GO:1990236":6,"GO:0009636":6,"GO:0042493":6,"GO:0043418":6,"GO:1990237":6},"recipe_readded":[]}