{"hash":"426745332610303488","title":"Transcription Initiation and Protein Turnover","description":"The cluster\u2019s top terms cluster around RNA polymerase II preinitiation complex assembly and DNA-templated transcription initiation, including a note on Notch-target transcription, pointing to gene expression regulation. The presence of SCF-dependent proteasomal ubiquitin-dependent protein catabolic process suggests coordinated protein turnover, reinforcing a theme of gene expression control and protein quality management. Some GO terms like SRP-dependent cotranslational targeting to membrane are less cohesive with this core, but the dominant signals support this label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_001154576.1","go_terms":[]},{"accession":"NP_177416.1","go_terms":[]},{"accession":"NP_197619.1","go_terms":[]},{"accession":"NP_566231.1","go_terms":[]},{"accession":"NP_567444.1","go_terms":[]},{"accession":"NP_568947.1","go_terms":["GO:0006614","GO:0006616"]},{"accession":"NP_001154641.1","go_terms":["GO:0031146"]},{"accession":"NP_001185221.1","go_terms":["GO:0007221","GO:0051090","GO:0051123","GO:0043966","GO:0006352"]},{"accession":"NP_001328326.1","go_terms":["GO:0016311","GO:0032259","GO:0015937"]},{"accession":"NP_175525.1","go_terms":["GO:0006281"]},{"accession":"NP_175715.1","go_terms":["GO:0031640","GO:0050832","GO:0042742","GO:0002229"]},{"accession":"NP_187974.1","go_terms":["GO:1901599"]},{"accession":"NP_192109.1","go_terms":[]},{"accession":"NP_567623.2","go_terms":["GO:0010286","GO:0019295"]},{"accession":"NP_001154658.1","go_terms":[]},{"accession":"NP_001185424.1","go_terms":[]},{"accession":"NP_001323219.1","go_terms":[]},{"accession":"NP_001323749.1","go_terms":["GO:0031146"]},{"accession":"NP_172614.1","go_terms":[]},{"accession":"NP_190704.2","go_terms":["GO:0030163","GO:0006508","GO:0045493","GO:0009627","GO:0002803","GO:0007586","GO:0019886","GO:0002018","GO:0016540","GO:0001823","GO:0002003","GO:0033619","GO:0070305","GO:0042985","GO:0042756","GO:0002016","GO:0050435"]},{"accession":"NP_568576.2","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0006616":1,"GO:0006614":1,"GO:0031146":2,"GO:0043966":1,"GO:0051123":1,"GO:0051090":1,"GO:0006352":1,"GO:0007221":1,"GO:0015937":1,"GO:0016311":1,"GO:0032259":1,"GO:0006281":1,"GO:0042742":1,"GO:0031640":1,"GO:0050832":1,"GO:0002229":1,"GO:1901599":1,"GO:0010286":1,"GO:0019295":1,"GO:0030163":1,"GO:0002003":1,"GO:0001823":1,"GO:0070305":1,"GO:0042985":1,"GO:0050435":1,"GO:0045493":1,"GO:0002016":1,"GO:0002018":1,"GO:0042756":1,"GO:0006508":1,"GO:0002803":1,"GO:0019886":1,"GO:0033619":1,"GO:0016540":1,"GO:0007586":1,"GO:0009627":1},"recipe_readded":["NP_175945.1","NP_850203.1","NP_180367.1"]}