{"hash":"2367778796385946","title":"Central carbon metabolism and fatty acid biosynthesis","description":"The proteins in this cluster are linked primarily to core energy and carbon-flow pathways: glycolysis, gluconeogenesis, pyruvate decarboxylation to acetyl-CoA, the TCA cycle, and subsequent steps leading to fatty acid biosynthesis and malonyl-CoA production. Some catabolic routes for amino acids (leucine, lysine) feeding into acetyl-CoA are present, which reinforces the acetyl-CoA\u2013driven metabolism theme. A couple of outlier terms (fruit ripening and sodium transport) and an obsolete GO term are present, but the dominant signal is central carbon metabolism funneling into lipid biosynthesis. ","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"members":[{"accession":"NP_197143.1","go_terms":["GO:0033512","GO:0006814","GO:0006099","GO:2001295","GO:0042759","GO:0006096","GO:0006086","GO:0006552","GO:0006213","GO:0006094"]},{"accession":"NP_191104.1","go_terms":["GO:0006642","GO:0032504","GO:0046166","GO:0009658","GO:0061621","GO:0006098","GO:0080022","GO:0019563","GO:0006094"]},{"accession":"NP_194091.1","go_terms":["GO:0034276","GO:0033512","GO:0042218","GO:0032869","GO:0000105","GO:0009102","GO:0019878","GO:0007219","GO:0006783","GO:0009862","GO:0019550","GO:0009236","GO:0006686","GO:0033585","GO:0015908","GO:0019441","GO:0006533","GO:0055089","GO:0006571","GO:0009835","GO:0019518","GO:0042853","GO:0097053","GO:0006523","GO:0006107","GO:0019551","GO:0006351","GO:0006532","GO:0006782","GO:0046511","GO:0033362"]},{"accession":"NP_181002.1","go_terms":["GO:0045487","GO:1902835","GO:0009686","GO:0042318","GO:0010023","GO:0009693","GO:0010421","GO:0046244","GO:0055114","GO:0009835","GO:0009852"]}],"graph":[["NP_197143.1","NP_191104.1",0.973],["NP_197143.1","NP_194091.1",0.969],["NP_191104.1","NP_194091.1",0.954]],"all_go_terms":{"GO:0006552":1,"GO:0006099":1,"GO:0042759":1,"GO:0006096":1,"GO:0006086":1,"GO:0006094":2,"GO:0033512":2,"GO:2001295":1,"GO:0006814":1,"GO:0006213":1,"GO:0019563":1,"GO:0009658":1,"GO:0080022":1,"GO:0061621":1,"GO:0046166":1,"GO:0032504":1,"GO:0006642":1,"GO:0006098":1,"GO:0015908":1,"GO:0042853":1,"GO:0033585":1,"GO:0006783":1,"GO:0019878":1,"GO:0046511":1,"GO:0006571":1,"GO:0009102":1,"GO:0019551":1,"GO:0000105":1,"GO:0097053":1,"GO:0006107":1,"GO:0006351":1,"GO:0006523":1,"GO:0009236":1,"GO:0032869":1,"GO:0033362":1,"GO:0019441":1,"GO:0006532":1,"GO:0006533":1,"GO:0019518":1,"GO:0009835":2,"GO:0009862":1,"GO:0019550":1,"GO:0006686":1,"GO:0006782":1,"GO:0055089":1,"GO:0042218":1,"GO:0007219":1,"GO:0034276":1,"GO:0009693":1,"GO:1902835":1,"GO:0042318":1,"GO:0055114":1,"GO:0009686":1,"GO:0045487":1,"GO:0009852":1,"GO:0010023":1,"GO:0010421":1,"GO:0046244":1},"recipe_readded":["NP_566685.1","NP_192787.1","NP_974614.1","NP_850613.1","NP_176294.1","NP_974407.1","NP_192894.1","NP_190692.1","NP_198709.1","NP_187068.1","NP_187069.1","NP_001331581.1","NP_172427.1","NP_001321632.1","NP_187244.1","NP_568981.2","NP_200170.2","NP_973858.1","NP_191153.1","NP_001323227.1"]}