{"hash":"230353826515894678","title":"SCF ubiquitin ligase in mitosis","description":"The cluster shows strong enrichment for SCF complex\u2013related ubiquitin-dependent proteolysis and mitotic control terms (G2/M transition, exit from mitosis, chromosome segregation), suggesting a cohesive role of SCF-mediated protein degradation in regulating mitosis. Additional signals for ubiquitin-dependent catabolism and DNA repair point to a broader genome maintenance theme, but the dominant pattern centers on SCF-driven regulation of mitotic progression.","confidence":"High","size":16,"edges":110,"triangles":444,"max_degree":15,"top_function":"chromosome segregation","members":[{"accession":"NP_566694.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_189869.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0006295","GO:0006294","GO:0006296","GO:0045116","GO:0010265","GO:0043162","GO:0000717","GO:0006293","GO:0000715","GO:0016567","GO:1902104","GO:0042769","GO:0016032","GO:0051759","GO:0031146","GO:0070911","GO:0070979","GO:0031145","GO:0051301","GO:0033151","GO:0033209","GO:0009048","GO:0036205","GO:0046328","GO:2000620","GO:0042981","GO:0007250","GO:0070512","GO:0085020","GO:0070535","GO:1903265","GO:1903762","GO:1903721","GO:1901253","GO:0090073"]},{"accession":"NP_566692.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_001185364.1","go_terms":["GO:0003283","GO:0010378","GO:0071947","GO:1990168","GO:0000381","GO:0003203","GO:0000122","GO:0043066","GO:1904404","GO:0046832","GO:0071600","GO:0008380","GO:0070536","GO:0006977","GO:0033132","GO:0035523","GO:1900871","GO:0045023","GO:0090526","GO:0036292","GO:0071301","GO:0016567","GO:0003181","GO:0071157","GO:1901487","GO:0032020","GO:0042138","GO:0010390","GO:0043951","GO:0090089","GO:0030509","GO:0043524","GO:0051569","GO:0031058","GO:0070936","GO:0006303","GO:0000086","GO:0035666","GO:0070534","GO:0043123","GO:1903955","GO:0010976","GO:0007288","GO:0031505","GO:0070423","GO:0070987","GO:0051865","GO:0016562","GO:0031497","GO:0051026","GO:0070911","GO:1902426","GO:0010620","GO:1990920","GO:0045116","GO:0031571","GO:0070459","GO:0071455","GO:0071596","GO:0033128","GO:0006348","GO:0007059","GO:0042276","GO:0038095","GO:0070193","GO:1901694","GO:0051443","GO:0071347","GO:0016558","GO:0085020","GO:0051965","GO:0045739","GO:0030466","GO:0031939","GO:0010845","GO:0006344","GO:0000722","GO:0007254","GO:0001701","GO:0042275","GO:0000724","GO:0070979","GO:0000729","GO:0060340","GO:1902916","GO:1904153","GO:1901044","GO:0010994","GO:0002223","GO:0031146","GO:0031145","GO:0045141","GO:0051092","GO:0044314","GO:0070076","GO:0070059","GO:0061186","GO:0071894","GO:0035519","GO:1903755","GO:0035458","GO:0000022","GO:0051301","GO:0009737","GO:0071629","GO:0050852","GO:0000278","GO:0006915","GO:0030433","GO:0033182","GO:0010458","GO:0016032"]},{"accession":"NP_174005.1","go_terms":["GO:0035518","GO:0031286","GO:0000086","GO:0048825","GO:0030154","GO:0000082","GO:0007295","GO:0051759","GO:2000819","GO:0044346","GO:0010100","GO:0001701","GO:0070979","GO:0048575","GO:0051232","GO:1903467","GO:0030853","GO:0042787","GO:0043149","GO:0000278","GO:0008283","GO:0031146","GO:0035019","GO:0050775","GO:0072576","GO:0007399","GO:0040016","GO:0001831","GO:0045773","GO:0031915","GO:1902104","GO:2000001","GO:0030097","GO:1900087","GO:0035024","GO:0019102","GO:0009640","GO:0017145"]},{"accession":"NP_564049.1","go_terms":["GO:1902564"]},{"accession":"NP_564105.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_565123.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_565604.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_566693.1","go_terms":["GO:0010458","GO:0060542","GO:0070911","GO:0007035","GO:0000086","GO:2000766","GO:0009734","GO:0031146","GO:0042787","GO:0016032","GO:0009873","GO:0007059","GO:0045910","GO:0007275"]},{"accession":"NP_001154726.1","go_terms":["GO:0006295","GO:0006294","GO:0006296","GO:0045116","GO:0010265","GO:0043162","GO:0000717","GO:0006293","GO:0000715","GO:0016567","GO:1902104","GO:0042769","GO:0016032","GO:0051759","GO:0031146","GO:0070911","GO:0070979","GO:0042787","GO:0031145","GO:0051301"]},{"accession":"NP_001154725.1","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936","GO:0006295","GO:0006294","GO:0006296","GO:0045116","GO:0010265","GO:0043162","GO:0000717","GO:0006293","GO:0000715","GO:0016567","GO:1902104","GO:0042769","GO:0016032","GO:0051759","GO:0031146","GO:0070911","GO:0070979","GO:0031145","GO:0051301"]},{"accession":"NP_190664.1","go_terms":["GO:0006260","GO:0006270","GO:0051301","GO:2001235","GO:0030154","GO:0034352","GO:0046672","GO:0002921","GO:0007291","GO:0035006","GO:0021556","GO:0001666","GO:0007275","GO:0000160","GO:0035070","GO:0051260","GO:0033353","GO:0001843","GO:0070328","GO:0035071","GO:0034349","GO:0007584","GO:0051402","GO:0010659","GO:0007568","GO:1902510","GO:0008635","GO:0072432","GO:0007420","GO:0007399","GO:0070059","GO:0070050","GO:0009626","GO:0071560","GO:0048813","GO:0030900","GO:1901053"]},{"accession":"NP_563864.2","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_567090.1","go_terms":["GO:0035518","GO:0000086","GO:0000226","GO:0051457","GO:0007275","GO:0009734","GO:0000921","GO:0042787","GO:0046686","GO:2000766","GO:0060542","GO:0031146","GO:0007059","GO:0010458","GO:0045910","GO:0010265","GO:0007035","GO:0016032","GO:0009873","GO:0070911"]},{"accession":"NP_850218.1","go_terms":["GO:1901487","GO:0032020","GO:0042138","GO:0010390","GO:0043951","GO:0090089","GO:0030509","GO:0043524","GO:0051569","GO:0031058","GO:0070936","GO:0006303","GO:0000086","GO:0035666","GO:0070534","GO:0043123","GO:1903955","GO:0010976","GO:0007288","GO:0031505","GO:0070423","GO:0070987","GO:0051865","GO:0016562","GO:0031497","GO:0051026","GO:0070911","GO:1902426","GO:0010620","GO:1990920","GO:0045116","GO:0031571","GO:0070459","GO:0071455","GO:0071596","GO:0033128","GO:0006348","GO:0007059","GO:0042276","GO:0038095","GO:0070193","GO:1901694","GO:0051443","GO:0071347","GO:0016558","GO:0085020","GO:0051965","GO:0045739","GO:0030466","GO:0031939","GO:0010845","GO:0006344","GO:0000722","GO:0007254","GO:0001701","GO:0042275","GO:0000724","GO:0070979","GO:0000729","GO:0060340","GO:1902916","GO:1904153","GO:1901044","GO:0010994","GO:0002223","GO:0031146","GO:0031145","GO:0045141","GO:0051092","GO:0044314","GO:0070076","GO:0070059","GO:0061186","GO:0071894","GO:0035519","GO:1903755","GO:0035458","GO:0000022","GO:0051301","GO:0009737","GO:0071629","GO:0050852","GO:0000278","GO:0006915","GO:0030433","GO:0033182","GO:0010458","GO:0016032"]}],"graph":[["NP_566692.1","NP_189869.1",0.932],["NP_566692.1","NP_190664.1",0.938],["NP_566692.1","NP_563864.2",0.96],["NP_566692.1","NP_564049.1",0.865],["NP_566692.1","NP_564105.1",0.96],["NP_566692.1","NP_565123.1",0.96],["NP_566692.1","NP_565604.1",0.96],["NP_566692.1","NP_850218.1",0.938],["NP_566692.1","NP_566693.1",0.958],["NP_566692.1","NP_566694.1",0.959],["NP_566692.1","NP_567090.1",0.96],["NP_566692.1","NP_001154725.1",0.821],["NP_566692.1","NP_001154726.1",0.959],["NP_566692.1","NP_001185364.1",0.94],["NP_189869.1","NP_174005.1",0.913],["NP_189869.1","NP_190664.1",0.973],["NP_189869.1","NP_563864.2",0.933],["NP_189869.1","NP_564049.1",0.977],["NP_189869.1","NP_564105.1",0.933],["NP_189869.1","NP_565604.1",0.733],["NP_189869.1","NP_566693.1",0.931],["NP_189869.1","NP_566694.1",0.817],["NP_189869.1","NP_850218.1",0.922],["NP_189869.1","NP_001154725.1",0.736],["NP_189869.1","NP_001154726.1",0.957],["NP_189869.1","NP_001185364.1",0.972],["NP_564049.1","NP_174005.1",0.896],["NP_564049.1","NP_190664.1",0.987],["NP_564049.1","NP_563864.2",0.959],["NP_564049.1","NP_564105.1",0.969],["NP_564049.1","NP_565123.1",0.978],["NP_564049.1","NP_565604.1",0.969],["NP_564049.1","NP_566693.1",0.967],["NP_564049.1","NP_566694.1",0.961],["NP_564049.1","NP_567090.1",0.984],["NP_564049.1","NP_850218.1",0.981],["NP_564049.1","NP_001154725.1",0.987],["NP_564049.1","NP_001154726.1",0.971],["NP_564049.1","NP_001185364.1",0.972],["NP_564105.1","NP_190664.1",0.958],["NP_564105.1","NP_563864.2",0.679],["NP_564105.1","NP_565123.1",0.671],["NP_564105.1","NP_566693.1",0.959],["NP_564105.1","NP_566694.1",0.67],["NP_564105.1","NP_567090.1",0.851],["NP_564105.1","NP_850218.1",0.659],["NP_564105.1","NP_001154725.1",0.855],["NP_564105.1","NP_001154726.1",0.96],["NP_564105.1","NP_001185364.1",0.576],["NP_566693.1","NP_174005.1",0.963],["NP_566693.1","NP_190664.1",0.973],["NP_566693.1","NP_563864.2",0.959],["NP_566693.1","NP_565123.1",0.959],["NP_566693.1","NP_565604.1",0.959],["NP_566693.1","NP_850218.1",0.858],["NP_566693.1","NP_566694.1",0.958],["NP_566693.1","NP_567090.1",0.959],["NP_566693.1","NP_001154725.1",0.853],["NP_566693.1","NP_001154726.1",0.958],["NP_566693.1","NP_001185364.1",0.962],["NP_001154726.1","NP_001154725.1",0.933],["NP_001154726.1","NP_001185364.1",0.988],["NP_001154726.1","NP_190664.1",0.979],["NP_001154726.1","NP_563864.2",0.959],["NP_001154726.1","NP_850218.1",0.981],["NP_001154726.1","NP_567090.1",0.959],["NP_001154726.1","NP_566694.1",0.959],["NP_001154726.1","NP_565123.1",0.959],["NP_001154726.1","NP_565604.1",0.96],["NP_850218.1","NP_190664.1",0.945],["NP_850218.1","NP_563864.2",0.974],["NP_850218.1","NP_565123.1",0.745],["NP_850218.1","NP_565604.1",0.859],["NP_850218.1","NP_566694.1",0.824],["NP_850218.1","NP_567090.1",0.618],["NP_850218.1","NP_001154725.1",0.938],["NP_850218.1","NP_001185364.1",0.769],["NP_001185364.1","NP_001154725.1",0.985],["NP_001185364.1","NP_190664.1",0.982],["NP_001185364.1","NP_563864.2",0.761],["NP_001185364.1","NP_567090.1",0.503],["NP_001185364.1","NP_566694.1",0.879],["NP_001185364.1","NP_565123.1",0.746],["NP_001185364.1","NP_565604.1",0.805],["NP_565123.1","NP_174005.1",0.686],["NP_565123.1","NP_190664.1",0.973],["NP_565123.1","NP_563864.2",0.96],["NP_565123.1","NP_567090.1",0.851],["NP_565123.1","NP_566694.1",0.96],["NP_565123.1","NP_565604.1",0.96],["NP_565123.1","NP_001154725.1",0.855],["NP_567090.1","NP_190664.1",0.947],["NP_567090.1","NP_563864.2",0.851],["NP_567090.1","NP_565604.1",0.853],["NP_567090.1","NP_566694.1",0.849],["NP_567090.1","NP_001154725.1",0.855],["NP_174005.1","NP_190664.1",0.734],["NP_174005.1","NP_563864.2",0.859],["NP_174005.1","NP_566694.1",0.6],["NP_174005.1","NP_001154725.1",0.732],["NP_190664.1","NP_563864.2",0.987],["NP_190664.1","NP_565604.1",0.968],["NP_190664.1","NP_566694.1",0.941],["NP_190664.1","NP_001154725.1",0.982],["NP_566694.1","NP_563864.2",0.85],["NP_566694.1","NP_565604.1",0.96],["NP_566694.1","NP_001154725.1",0.934],["NP_563864.2","NP_565604.1",0.679],["NP_563864.2","NP_001154725.1",0.934],["NP_001154725.1","NP_565604.1",0.855]],"all_go_terms":{"GO:0045910":8,"GO:0010458":10,"GO:0000921":7,"GO:0009734":8,"GO:0016032":13,"GO:0009873":8,"GO:0007035":8,"GO:0000226":7,"GO:0046686":7,"GO:0070911":13,"GO:0035518":8,"GO:0007275":9,"GO:0010265":10,"GO:0031146":14,"GO:0060542":8,"GO:0007059":10,"GO:2000766":8,"GO:0042787":12,"GO:0051457":7,"GO:0000086":11,"GO:0006293":3,"GO:0070936":4,"GO:0051301":6,"GO:0042981":1,"GO:0033151":1,"GO:0045116":5,"GO:0043162":3,"GO:0070535":1,"GO:1901253":1,"GO:0000717":3,"GO:0038018":2,"GO:0007250":1,"GO:1903265":1,"GO:0070979":6,"GO:0006296":3,"GO:0016558":4,"GO:2000620":1,"GO:1900095":2,"GO:0009048":1,"GO:1902104":4,"GO:0036205":1,"GO:0031145":5,"GO:0006295":3,"GO:0000715":3,"GO:1903721":1,"GO:0030433":4,"GO:0033209":1,"GO:0046621":2,"GO:0060816":2,"GO:0042769":3,"GO:0006294":3,"GO:0051759":4,"GO:0085020":3,"GO:0090073":1,"GO:0051865":4,"GO:1903762":1,"GO:0016567":4,"GO:0070512":1,"GO:0046328":1,"GO:0006303":2,"GO:0006915":2,"GO:0042276":2,"GO:0043066":1,"GO:1904404":1,"GO:0035458":2,"GO:0071894":2,"GO:0010390":2,"GO:0008380":1,"GO:0042138":2,"GO:0070193":2,"GO:0051569":2,"GO:1901487":2,"GO:1903955":2,"GO:0002223":2,"GO:0070423":2,"GO:0035523":1,"GO:0071157":1,"GO:0051092":2,"GO:0001701":3,"GO:0003283":1,"GO:1900871":1,"GO:0000122":1,"GO:0071596":2,"GO:0043123":2,"GO:0071600":1,"GO:0045023":1,"GO:0006344":2,"GO:0010994":2,"GO:1901694":2,"GO:0070987":2,"GO:0033132":1,"GO:1990920":2,"GO:1903755":2,"GO:1902916":2,"GO:0000724":2,"GO:0070536":1,"GO:0070534":2,"GO:0007288":2,"GO:0090526":1,"GO:1901044":2,"GO:1990168":1,"GO:0061186":2,"GO:0051026":2,"GO:1904153":2,"GO:0000729":2,"GO:0060340":2,"GO:0033128":2,"GO:0031058":2,"GO:0070459":2,"GO:0007254":2,"GO:0071301":1,"GO:0071629":2,"GO:0051443":2,"GO:0010845":2,"GO:0010378":1,"GO:0043951":2,"GO:0032020":2,"GO:0090089":2,"GO:0003181":1,"GO:0071455":2,"GO:0035519":2,"GO:0045141":2,"GO:0031497":2,"GO:0031505":2,"GO:0042275":2,"GO:0000381":1,"GO:0006977":1,"GO:1902426":2,"GO:0030466":2,"GO:0070076":2,"GO:0050852":2,"GO:0043524":2,"GO:0031571":2,"GO:0038095":2,"GO:0070059":3,"GO:0033182":2,"GO:0045739":2,"GO:0010620":2,"GO:0010976":2,"GO:0044314":2,"GO:0031939":2,"GO:0071947":1,"GO:0003203":1,"GO:0000278":3,"GO:0036292":1,"GO:0009737":2,"GO:0046832":1,"GO:0006348":2,"GO:0000022":2,"GO:0016562":2,"GO:0051965":2,"GO:0035666":2,"GO:0030509":2,"GO:0071347":2,"GO:0000722":2,"GO:0048575":1,"GO:0031915":1,"GO:0009640":1,"GO:0008283":1,"GO:0030853":1,"GO:0040016":1,"GO:0050775":1,"GO:2000819":1,"GO:0019102":1,"GO:0030097":1,"GO:0017145":1,"GO:0007399":2,"GO:0010100":1,"GO:0001831":1,"GO:0035024":1,"GO:0072576":1,"GO:0000082":1,"GO:0051232":1,"GO:1903467":1,"GO:0031286":1,"GO:0030154":2,"GO:0035019":1,"GO:0007295":1,"GO:0045773":1,"GO:2000001":1,"GO:1900087":1,"GO:0048825":1,"GO:0043149":1,"GO:0044346":1,"GO:1902564":1,"GO:0007568":1,"GO:0033353":1,"GO:0048813":1,"GO:0034352":1,"GO:0030900":1,"GO:0021556":1,"GO:0034349":1,"GO:0001666":1,"GO:0035071":1,"GO:0070050":1,"GO:0072432":1,"GO:0009626":1,"GO:0010659":1,"GO:0071560":1,"GO:0035070":1,"GO:0035006":1,"GO:0070328":1,"GO:0046672":1,"GO:0007584":1,"GO:1902510":1,"GO:0002921":1,"GO:0008635":1,"GO:0007420":1,"GO:1901053":1,"GO:0051402":1,"GO:0006260":1,"GO:0051260":1,"GO:0001843":1,"GO:0007291":1,"GO:0000160":1,"GO:0006270":1,"GO:2001235":1},"recipe_readded":[]}