{"hash":"118570586290063376","title":"Cellular stress response and secretory trafficking","description":"The GO terms point to engagement in ER-to-Golgi vesicle transport, oxidative stress\u2013related apoptotic signaling, and cellular detoxification, all, together with regulation of transcriptional activity and nuclear-cytoplasmic trafficking. This pattern suggests a coordinated response to cellular stress that involves both secretory pathway dynamics and stress-induced gene regulation. Prolyl hydroxylation also hints at stress-related post-translational modification activities. Overall, the cluster seems centered on stress response with links to trafficking and protein regulation rather than a single pathway, hence the name.","confidence":"Medium","size":18,"edges":32,"triangles":8,"max_degree":7,"top_function":null,"members":[{"accession":"NP_001321805.1","go_terms":["GO:0006929","GO:0007292","GO:0061164","GO:0051639","GO:0051758","GO:0070649","GO:0045010","GO:0071519","GO:2000251","GO:0010467","GO:1904171","GO:0072092","GO:0055003","GO:0051295","GO:0051660","GO:0008360","GO:0071420","GO:0060292","GO:0040038","GO:1904670"]},{"accession":"NP_683291.2","go_terms":[]},{"accession":"NP_568384.1","go_terms":[]},{"accession":"NP_180103.2","go_terms":[]},{"accession":"NP_198742.2","go_terms":["GO:0006949","GO:0019953","GO:0009828","GO:0050832"]},{"accession":"NP_566774.1","go_terms":[]},{"accession":"NP_567395.1","go_terms":["GO:0048147","GO:0042590","GO:1900426","GO:0019886"]},{"accession":"NP_177344.2","go_terms":["GO:0097150","GO:0006486","GO:0036071","GO:0042355","GO:0010493","GO:0021799","GO:0002361","GO:0002522"]},{"accession":"NP_201562.1","go_terms":[]},{"accession":"NP_850043.2","go_terms":[]},{"accession":"NP_567776.1","go_terms":["GO:0002037","GO:0006888","GO:0008631","GO:0010917"]},{"accession":"NP_567765.2","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0006888"]},{"accession":"NP_566664.1","go_terms":["GO:0033158","GO:0043388","GO:0045454","GO:0000122","GO:0098869","GO:1903206","GO:0006662","GO:0080058","GO:0034599","GO:0018401","GO:0055114","GO:0046826","GO:0006351","GO:0016032","GO:1903026","GO:0034976","GO:0034975","GO:0030091","GO:0006888"]},{"accession":"NP_173139.1","go_terms":[]},{"accession":"NP_680203.1","go_terms":[]},{"accession":"NP_973574.1","go_terms":[]},{"accession":"NP_001154191.1","go_terms":["GO:0002037","GO:0006888","GO:0008631","GO:0010917"]},{"accession":"NP_001078023.1","go_terms":[]}],"graph":[["NP_201562.1","NP_850043.2",0.521],["NP_201562.1","NP_001154191.1",0.538],["NP_567765.2","NP_567395.1",0.851],["NP_567765.2","NP_567776.1",0.926],["NP_567765.2","NP_683291.2",0.675],["NP_567765.2","NP_850043.2",0.804],["NP_567765.2","NP_001078023.1",0.6],["NP_567765.2","NP_001154191.1",0.812],["NP_567765.2","NP_001321805.1",0.913],["NP_566664.1","NP_180103.2",0.517],["NP_566664.1","NP_973574.1",0.823],["NP_566664.1","NP_850043.2",0.898],["NP_566664.1","NP_680203.1",0.634],["NP_566664.1","NP_567776.1",0.701],["NP_566664.1","NP_001078023.1",0.69],["NP_566664.1","NP_001154191.1",0.928],["NP_568384.1","NP_198742.2",0.702],["NP_568384.1","NP_973574.1",0.648],["NP_568384.1","NP_850043.2",0.591],["NP_568384.1","NP_683291.2",0.852],["NP_683291.2","NP_177344.2",0.92],["NP_683291.2","NP_567776.1",0.764],["NP_683291.2","NP_973574.1",0.765],["NP_177344.2","NP_973574.1",0.826],["NP_850043.2","NP_180103.2",0.773],["NP_850043.2","NP_566774.1",0.557],["NP_973574.1","NP_180103.2",0.731],["NP_973574.1","NP_680203.1",0.652],["NP_680203.1","NP_198742.2",0.559],["NP_680203.1","NP_001078023.1",0.637],["NP_001078023.1","NP_001321805.1",0.707],["NP_001078023.1","NP_566774.1",0.71]],"all_go_terms":{"GO:0051639":1,"GO:0071519":1,"GO:0070649":1,"GO:2000251":1,"GO:0071420":1,"GO:1904670":1,"GO:0051758":1,"GO:1904171":1,"GO:0008360":1,"GO:0007292":1,"GO:0006929":1,"GO:0055003":1,"GO:0060292":1,"GO:0051295":1,"GO:0040038":1,"GO:0051660":1,"GO:0072092":1,"GO:0061164":1,"GO:0045010":1,"GO:0010467":1,"GO:0006949":1,"GO:0019953":1,"GO:0009828":1,"GO:0050832":1,"GO:0019886":1,"GO:0048147":1,"GO:0042590":1,"GO:1900426":1,"GO:0002361":1,"GO:0010493":1,"GO:0042355":1,"GO:0021799":1,"GO:0036071":1,"GO:0097150":1,"GO:0006486":1,"GO:0002522":1,"GO:0006888":4,"GO:0010917":2,"GO:0008631":2,"GO:0002037":2,"GO:1903026":2,"GO:0018401":2,"GO:0098869":2,"GO:0016032":2,"GO:0043388":2,"GO:0046826":2,"GO:0034599":2,"GO:0006351":2,"GO:0080058":2,"GO:0055114":2,"GO:0034975":2,"GO:0006662":2,"GO:0034976":2,"GO:1903206":2,"GO:0000122":2,"GO:0030091":2,"GO:0045454":2,"GO:0033158":2},"recipe_readded":[]}