{"hash":"1169965148920176877","title":"ER stress response and protein folding","description":"The GO terms prominent in this cluster point to ER-associated protein handling and stress response, including cellular response to unfolded protein, SRP-dependent cotranslational targeting to the membrane and translocation to the ER, and negative regulation of ER-stress\u2013induced apoptotic signaling. While a few terms (DNA replication, karyogamy, iron-sulfur cluster assembly) are less clearly connected, the dominant theme is ER protein quality control and unfolded protein response.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_172631.2","go_terms":["GO:0000902","GO:0090084","GO:1903382","GO:1900035","GO:0000742","GO:0006880","GO:0016226","GO:1902037","GO:0070880","GO:0006260","GO:0034620","GO:0031204","GO:1903751","GO:0006616","GO:0070389"]},{"accession":"NP_195923.1","go_terms":[]},{"accession":"NP_173838.1","go_terms":["GO:0019322","GO:0043523","GO:0021762","GO:0010041","GO:1904879","GO:0014070","GO:0032094","GO:0006740","GO:2000378","GO:0045471","GO:0009051","GO:0061052","GO:0042542","GO:0010734","GO:0006098","GO:0006695","GO:0043249","GO:0006006"]},{"accession":"NP_177191.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0006260":1,"GO:0006616":1,"GO:0016226":1,"GO:1900035":1,"GO:0000902":1,"GO:1903382":1,"GO:1903751":1,"GO:0034620":1,"GO:0070389":1,"GO:0000742":1,"GO:0090084":1,"GO:0006880":1,"GO:1902037":1,"GO:0070880":1,"GO:0031204":1,"GO:2000378":1,"GO:0006740":1,"GO:0010734":1,"GO:0045471":1,"GO:0010041":1,"GO:0019322":1,"GO:0014070":1,"GO:0009051":1,"GO:0061052":1,"GO:0043523":1,"GO:0042542":1,"GO:0006695":1,"GO:0043249":1,"GO:0006006":1,"GO:1904879":1,"GO:0032094":1,"GO:0021762":1,"GO:0006098":1},"recipe_readded":["NP_173515.2","NP_001321065.1","NP_189282.1","NP_001330303.1","NP_193387.1","NP_564143.1","NP_174298.1","NP_199259.1","NP_192194.2","NP_179521.1","NP_001154497.1","NP_564322.1","NP_001319291.1","NP_199571.2","NP_566283.1","NP_181079.1","NP_566518.1","NP_192371.1","NP_189217.1","NP_001328470.1"]}