{"hash":"2028306625837286966","title":"P53-Mediated DNA Damage Response and Translation Regulation","description":"This cluster centers on gene expression control under DNA damage/UV stress, combining translation regulation (and ribosome biogenesis) with transcription elongation and p53-mediated DNA damage response signals. The presence of GO terms for translation, transcription elongation, ribosome biogenesis, and p53-driven apoptotic signaling suggests proteins in this cluster coordinate transcription and translation to manage stress-induced cell fate.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"members":[{"accession":"NP_036183.1","go_terms":["GO:0002181","GO:1990090","GO:0032543"]},{"accession":"NP_001392894.1","go_terms":["GO:0042255","GO:0046677","GO:0000448","GO:0006412"]},{"accession":"NP_033106.1","go_terms":["GO:0042273","GO:0071480","GO:1902167","GO:0042256","GO:0006977","GO:0034644","GO:0045727","GO:1902164","GO:0006412","GO:1904803","GO:0032784","GO:0031564","GO:0006354","GO:0006353"]},{"accession":"NP_033107.1","go_terms":["GO:1903955","GO:0000463","GO:0000466","GO:0006412","GO:1903146"]},{"accession":"NP_062621.2","go_terms":["GO:0006412"]},{"accession":"NP_081035.1","go_terms":["GO:1901194","GO:0006412"]},{"accession":"NP_666072.3","go_terms":["GO:0070126","GO:0006412"]},{"accession":"NP_780583.1","go_terms":["GO:0070126","GO:0006412"]},{"accession":"NP_035419.1","go_terms":["GO:1902164","GO:1902167","GO:0032784","GO:0006977","GO:1904803","GO:0042273","GO:0031564","GO:0071480","GO:0006354","GO:0006353","GO:0045727","GO:0006412"]}],"graph":[["NP_001392894.1","NP_036183.1",0.892],["NP_001392894.1","NP_035419.1",0.834],["NP_001392894.1","NP_033106.1",0.899],["NP_001392894.1","NP_033107.1",0.96],["NP_001392894.1","NP_081035.1",0.897],["NP_001392894.1","NP_062621.2",0.88],["NP_001392894.1","NP_780583.1",0.95],["NP_001392894.1","NP_666072.3",0.949],["NP_666072.3","NP_033106.1",0.96],["NP_666072.3","NP_033107.1",0.965],["NP_666072.3","NP_035419.1",0.961],["NP_666072.3","NP_036183.1",0.948],["NP_666072.3","NP_062621.2",0.963],["NP_666072.3","NP_081035.1",0.971],["NP_666072.3","NP_780583.1",0.986],["NP_033106.1","NP_033107.1",0.825],["NP_033106.1","NP_035419.1",0.606],["NP_033106.1","NP_036183.1",0.691],["NP_033106.1","NP_081035.1",0.673],["NP_033106.1","NP_062621.2",0.729],["NP_033106.1","NP_780583.1",0.957],["NP_780583.1","NP_033107.1",0.962],["NP_780583.1","NP_035419.1",0.953],["NP_780583.1","NP_036183.1",0.926],["NP_780583.1","NP_062621.2",0.956],["NP_780583.1","NP_081035.1",0.955],["NP_062621.2","NP_033107.1",0.863],["NP_062621.2","NP_035419.1",0.64],["NP_062621.2","NP_036183.1",0.848],["NP_062621.2","NP_081035.1",0.78],["NP_035419.1","NP_033107.1",0.77],["NP_035419.1","NP_036183.1",0.693],["NP_035419.1","NP_081035.1",0.698],["NP_036183.1","NP_033107.1",0.871],["NP_036183.1","NP_081035.1",0.554],["NP_033107.1","NP_081035.1",0.845]],"all_go_terms":{"GO:0032543":1,"GO:1990090":1,"GO:0002181":1,"GO:0000448":1,"GO:0046677":1,"GO:0042255":1,"GO:0006412":8,"GO:1904803":2,"GO:0006977":2,"GO:1902164":2,"GO:0031564":2,"GO:0006354":2,"GO:0034644":1,"GO:0042273":2,"GO:0032784":2,"GO:0045727":2,"GO:1902167":2,"GO:0071480":2,"GO:0006353":2,"GO:0042256":1,"GO:1903955":1,"GO:0000463":1,"GO:0000466":1,"GO:1903146":1,"GO:1901194":1,"GO:0070126":2},"recipe_readded":[]}