{"hash":"1849806257147218136","title":"ER quality control and ER-to-Golgi trafficking","description":"This cluster shows GO terms centered on the secretory pathway: endoplasmic reticulum to Golgi vesicle-mediated transport, ubiquitin-dependent ERAD, and ER-associated protein quality control. Additional terms touch on post-translational targeting and protein folding/refolding, reinforcing a proteostasis/trafficking theme. A couple of terms (splicing, heat response) are peripheral given the small cluster size. Overall, the proteins are best characterized by roles in managing misfolded proteins and directing them through the ER-Golgi pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_080829.1","go_terms":["GO:0006888"]},{"accession":"NP_084322.2","go_terms":["GO:0000055","GO:0032298","GO:0000398","GO:1903026","GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"NP_082657.1","go_terms":["GO:0000349","GO:0000387"]}],"graph":[],"all_go_terms":{"GO:0006888":1,"GO:0071630":1,"GO:0030433":1,"GO:0006452":1,"GO:0070389":1,"GO:0000398":1,"GO:0009408":1,"GO:0046825":1,"GO:1901621":1,"GO:0031204":1,"GO:0006626":1,"GO:0036494":1,"GO:0090084":1,"GO:1900035":1,"GO:0001707":1,"GO:0045454":1,"GO:0006986":1,"GO:0006469":1,"GO:0071374":1,"GO:0006458":1,"GO:0006260":1,"GO:0051259":1,"GO:1903026":1,"GO:0032298":1,"GO:0097428":1,"GO:0032781":1,"GO:0035719":1,"GO:0034975":1,"GO:0000055":1,"GO:0070843":1,"GO:0000387":1,"GO:0000349":1},"recipe_readded":["NP_001365454.1","NP_871788.1","NP_033306.2","NP_659171.1","NP_001154841.1","XP_006526011.1","NP_001074574.1","NP_001409039.1","NP_001154842.1","XP_030102161.1","NP_001154843.1","XP_036009809.1","NP_001033030.2","NP_081703.1","XP_030106329.1","NP_031509.1","NP_058082.2","XP_036008843.1","NP_083342.1","NP_663600.2"]}