{"hash":"1501344489463623096","title":"Deubiquitination-Regulated Immune Signaling","description":"The proteins appear to function as deubiquitinases with linkage-specific activity (K27, K48, K29) and influence histone ubiquitination, which can modulate gene expression and signaling. The GO terms point to immune regulation (negative IL-2 production, CD40 signaling, mucosal immune response, LPS tolerance) and responses to bacterial components (muramyl dipeptide). Together, this suggests a theme of ubiquitin editing shaping immune signaling and mucosal tolerance rather than classic effector responses.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"members":[{"accession":"NP_033438.1","go_terms":[]},{"accession":"NP_001156663.1","go_terms":["GO:0006281","GO:0071347","GO:0071108","GO:0035871","GO:2000780","GO:0002250","GO:1901315","GO:0070536","GO:1902042","GO:2000347","GO:2000349","GO:0071947","GO:1990167","GO:0032495","GO:1990168","GO:0002385","GO:0002677","GO:0070433","GO:0032691","GO:0043124","GO:0032703","GO:2000352","GO:0001922","GO:0002634","GO:0034140","GO:0035523","GO:0034148","GO:0072573","GO:0044313","GO:0070429","GO:0032717","GO:0016567"]},{"accession":"NP_001033703.1","go_terms":["GO:0014032","GO:0007399","GO:0010718","GO:0007275","GO:0051152","GO:0060317","GO:0023041","GO:0003190","GO:0030516","GO:2001223","GO:1902430"]},{"accession":"NP_083568.2","go_terms":[]}],"graph":[["NP_033438.1","NP_001033703.1",0.592],["NP_001156663.1","NP_001033703.1",0.758],["NP_001033703.1","NP_083568.2",0.695]],"all_go_terms":{"GO:0032703":1,"GO:1990167":1,"GO:1901315":1,"GO:0002385":1,"GO:0071108":1,"GO:0032495":1,"GO:0035523":1,"GO:1902042":1,"GO:2000349":1,"GO:0072573":1,"GO:0032691":1,"GO:0071347":1,"GO:0032717":1,"GO:0044313":1,"GO:2000780":1,"GO:0070433":1,"GO:0043124":1,"GO:0070536":1,"GO:0001922":1,"GO:0002634":1,"GO:0034148":1,"GO:0002250":1,"GO:0071947":1,"GO:0035871":1,"GO:2000347":1,"GO:0002677":1,"GO:0016567":1,"GO:1990168":1,"GO:0070429":1,"GO:0034140":1,"GO:0006281":1,"GO:2000352":1,"GO:0023041":1,"GO:0007275":1,"GO:0060317":1,"GO:2001223":1,"GO:0010718":1,"GO:0051152":1,"GO:0014032":1,"GO:0007399":1,"GO:0030516":1,"GO:0003190":1,"GO:1902430":1},"recipe_readded":[]}