{"hash":"1168825732655537333","title":"Macrophage activation and lipid remodeling","description":"This cluster converges on immune activation in macrophages (regulation of macrophage activation; IL-1 and IL-8 production) and concurrent lipid handling (lipid storage regulation, lipid catabolic processes, and phospholipid acyl-chain remodeling), including foam-cell differentiation. This points to a coordinated inflammatory response in macrophages paired with lipid metabolism, a pattern relevant to atherosclerosis-related processes.","confidence":"Medium","size":17,"edges":17,"triangles":1,"max_degree":16,"top_function":null,"members":[{"accession":"NP_077177.2","go_terms":["GO:0000055","GO:0032298","GO:0000398","GO:1903026"]},{"accession":"XP_036018660.1","go_terms":["GO:0046677","GO:0006412","GO:0046898"]},{"accession":"XP_017172476.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"NP_001078862.1","go_terms":["GO:0019835","GO:0005989","GO:0019730","GO:0007342","GO:0016998","GO:0009566","GO:0035036","GO:0042742","GO:0006954","GO:0001895","GO:1903496","GO:1903494","GO:0051672"]},{"accession":"NP_001364004.1","go_terms":["GO:0021814","GO:0038026","GO:0036324","GO:0007129","GO:0045141","GO:0070197"]},{"accession":"NP_065610.2","go_terms":["GO:0018230","GO:0043001","GO:0006612"]},{"accession":"NP_904330.1","go_terms":["GO:0015990","GO:0006123","GO:0019411","GO:0019646","GO:0006119"]},{"accession":"NP_035237.1","go_terms":["GO:0042130","GO:0006654","GO:0034374","GO:0019731","GO:0044240","GO:0036148","GO:0036149","GO:0032612","GO:0002361","GO:0002446","GO:0045740","GO:0010744","GO:0051977","GO:0019370","GO:0090238","GO:0032637","GO:0090370","GO:0050830","GO:0002227","GO:0036151","GO:0036150","GO:0036152","GO:0050482","GO:0010518","GO:0010884","GO:0043030","GO:0070374","GO:0032308"]},{"accession":"NP_001350246.1","go_terms":["GO:0097428","GO:0006879","GO:0009399","GO:0016226"]},{"accession":"NP_904328.1","go_terms":["GO:0019684","GO:0042773"]},{"accession":"NP_808212.2","go_terms":["GO:0032148","GO:0032431","GO:0006651","GO:0034332","GO:0030154","GO:0001666","GO:0007275","GO:0001525","GO:0007202","GO:0048662","GO:0009303","GO:0030041","GO:0001556","GO:0090502","GO:0050714","GO:0001938","GO:0017148","GO:0060474"]},{"accession":"NP_036197.1","go_terms":["GO:0000187","GO:0045745","GO:0045742","GO:0016056","GO:0007601"]},{"accession":"NP_001405108.1","go_terms":["GO:0042327","GO:0031031","GO:2000100","GO:0007118","GO:0000920"]},{"accession":"NP_001405283.1","go_terms":["GO:0046079"]},{"accession":"NP_001034087.1","go_terms":["GO:0031397","GO:0010596"]},{"accession":"NP_001243090.1","go_terms":[]},{"accession":"NP_001263279.1","go_terms":[]}],"graph":[["NP_065610.2","NP_035237.1",0.563],["XP_036018660.1","NP_035237.1",0.652],["NP_904330.1","NP_035237.1",0.628],["NP_904330.1","NP_904328.1",0.587],["NP_001350246.1","NP_035237.1",0.657],["NP_001078862.1","NP_035237.1",0.5],["XP_017172476.1","NP_035237.1",0.511],["NP_904328.1","NP_035237.1",0.63],["NP_001243090.1","NP_035237.1",0.787],["NP_001263279.1","NP_035237.1",0.589],["NP_036197.1","NP_035237.1",0.605],["NP_001034087.1","NP_035237.1",0.588],["NP_001405108.1","NP_035237.1",0.863],["NP_001364004.1","NP_035237.1",0.625],["NP_808212.2","NP_035237.1",0.519],["NP_001405283.1","NP_035237.1",0.547],["NP_077177.2","NP_035237.1",0.566]],"all_go_terms":{"GO:0000398":1,"GO:1903026":1,"GO:0000055":1,"GO:0032298":1,"GO:0046677":1,"GO:0046898":1,"GO:0006412":1,"GO:0043030":2,"GO:0032612":2,"GO:0010744":2,"GO:0036148":2,"GO:0036152":2,"GO:0010518":2,"GO:0050830":2,"GO:0010884":2,"GO:0032637":2,"GO:0044240":2,"GO:0045740":2,"GO:0002446":2,"GO:0036150":2,"GO:0006654":2,"GO:0032308":2,"GO:0036149":2,"GO:0019370":2,"GO:0002227":2,"GO:0051977":2,"GO:0050482":2,"GO:0090238":2,"GO:0090370":2,"GO:0002361":2,"GO:0019731":2,"GO:0036151":2,"GO:0034374":2,"GO:0042130":2,"GO:0070374":2,"GO:1903496":1,"GO:0042742":1,"GO:0005989":1,"GO:0016998":1,"GO:0051672":1,"GO:0009566":1,"GO:0001895":1,"GO:0006954":1,"GO:0019730":1,"GO:1903494":1,"GO:0007342":1,"GO:0035036":1,"GO:0019835":1,"GO:0045141":1,"GO:0021814":1,"GO:0070197":1,"GO:0038026":1,"GO:0007129":1,"GO:0036324":1,"GO:0006612":1,"GO:0018230":1,"GO:0043001":1,"GO:0006123":1,"GO:0015990":1,"GO:0006119":1,"GO:0019646":1,"GO:0019411":1,"GO:0097428":1,"GO:0009399":1,"GO:0016226":1,"GO:0006879":1,"GO:0042773":1,"GO:0019684":1,"GO:0001666":1,"GO:0032148":1,"GO:0034332":1,"GO:0007275":1,"GO:0007202":1,"GO:0001556":1,"GO:0050714":1,"GO:0030041":1,"GO:0090502":1,"GO:0032431":1,"GO:0001525":1,"GO:0017148":1,"GO:0001938":1,"GO:0030154":1,"GO:0048662":1,"GO:0009303":1,"GO:0060474":1,"GO:0006651":1,"GO:0000187":1,"GO:0016056":1,"GO:0045742":1,"GO:0045745":1,"GO:0007601":1,"GO:0031031":1,"GO:0007118":1,"GO:0042327":1,"GO:0000920":1,"GO:2000100":1,"GO:0046079":1,"GO:0010596":1,"GO:0031397":1},"recipe_readded":[]}