[{"hash":"508105691427258263","title":"Neural development and cell-cycle regulation","description":"Top terms indicate neural development (axonogenesis, excitatory postsynaptic potential, visual perception, Schwann cell development) and mitotic control (mitotic cell cycle, G2/M transition), with additional developmental signals (heart development; apoptosis regulation). This suggests proteins that coordinate neural differentiation with cell proliferation and survival cues.","confidence":"Medium","size":29,"edges":65,"triangles":26,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":16},{"id":"GO:0060079","count":16},{"id":"GO:0007507","count":15},{"id":"GO:0043065","count":15},{"id":"GO:0007601","count":15}]},{"hash":"1996712932391987718","title":"Growth factor\u2013mediated signaling with Ca2+ regulation","description":"This cluster is enriched for GO terms tied to responses to growth factors and cytokines (TGF-beta, M-CSF, insulin), alongside core signaling activities such as calcium release into the cytosol, calcium-mediated signaling, STAT phosphorylation, and PI3K-related signaling. The presence of cell-cell signaling and neutrophil chemotaxis, plus developmental branching in mammary gland morphogenesis, suggests a cohesive signaling network that governs proliferation, migration, and differentiation in response to extracellular cues, with calcium signaling serving as a central mediator. ","confidence":"High","size":29,"edges":148,"triangles":464,"max_degree":18,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071560","count":20},{"id":"GO:0036006","count":20},{"id":"GO:0051281","count":20},{"id":"GO:0060444","count":20},{"id":"GO:0042531","count":20}]},{"hash":"988103446705136863","title":"Retinal cGMP signaling and cone development","description":"This cluster shows strong enrichment for GO terms linked to cGMP signaling and retinal development, notably cellular response to cGMP and retinal cone cell development, along with regulation of guanylyl cyclase signaling. While some terms pertain to broader stimuli or cytokine responses, the dominant theme is cGMP-mediated signaling in retinal cells, aligning with phototransduction and cone maturation. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007608","count":16},{"id":"GO:0010754","count":16},{"id":"GO:0071321","count":16},{"id":"GO:0071560","count":14},{"id":"GO:0097011","count":14}]},{"hash":"1611008642237306028","title":"Developmental neurogenesis and organogenesis","description":"The cluster contains terms spanning neural development (visceral motor neuron differentiation, lateral motor column neuron migration), organ formation (female gonad development, nephric duct elongation), and supporting processes like muscle stretch detection and transcriptional regulation, suggesting a broad developmental/organogenesis theme rather than a single pathway.","confidence":"Medium","size":29,"edges":26,"triangles":29,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030579","count":16},{"id":"GO:0008585","count":15},{"id":"GO:2000637","count":15},{"id":"GO:0097067","count":15},{"id":"GO:0030835","count":15}]},{"hash":"2109774026352412673","title":"Neural cell adhesion and axon junction organization","description":"Top terms indicate a strong emphasis on neural cell adhesion and axon organization: heterophilic and homophilic adhesion, paranodal junction assembly, protein localization to the juxtaparanode region, and positive regulation of synapse assembly, plus nerve structural organization. These features together point to a cluster enriched for neural cell adhesion molecules and roles in axon-paranode/synapse assembly.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0030913","count":12},{"id":"GO:0043931","count":12},{"id":"GO:0007156","count":11},{"id":"GO:0071205","count":11}]},{"hash":"1353654979061656765","title":"Neural cell adhesion and synapse assembly","description":"The cluster is strongly enriched for neural-related GO terms: high representation of heterophilic and homophilic cell-cell adhesion, nervous system development, and positive regulation of synapse assembly, plus paranodal junction assembly. While some immune terms appear, the prevailing signals point to roles in neuronal cell adhesion and synapse formation, suggesting these proteins cooperate in neural connectivity and maturation.","confidence":"High","size":29,"edges":6,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":24},{"id":"GO:0007156","count":21},{"id":"GO:0043931","count":20},{"id":"GO:0051965","count":18},{"id":"GO:0007399","count":17}]},{"hash":"485581368204231148","title":"Actin-Driven Cell Migration and Polarity","description":"The cluster centers on actin cytoskeleton dynamics\u2014filament assembly and polymerization\u2014together with cell migration and establishment of polarity (epithelial), as well as signaling pathways like ephrin receptor and T cell receptor signaling. The inclusion of dendritic spine morphogenesis likewise points to actin-driven remodeling in neural contexts, suggesting a unifying theme of cytoskeletal remodeling that enables movement and polarized signaling across cell types, including immune and neuronal cells.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:0090162","count":6},{"id":"GO:0051017","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0050798","count":6}]},{"hash":"1211728956628463743","title":"Neural development and potassium ion transport","description":"The top GO terms cluster around neural-related morphogenesis and signaling (dendrite morphogenesis, sensory perception of pain, chemotaxis) alongside potassium ion transport, suggesting a group of proteins involved in neural development and ion homeostasis. While there are also broad terms for development and gene expression (DNA replication, transcription, nuclear export), the neural and ion transport themes are prominent, supporting a cohesive label focused on neural differentiation with ion-channel activity.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006813","count":20},{"id":"GO:0048701","count":20},{"id":"GO:0006260","count":20},{"id":"GO:0007275","count":19},{"id":"GO:0048813","count":19}]},{"hash":"1573864381145979118","title":"Bacterial Surface Biosynthesis and Adhesion","description":"The cluster\u2019s top GO terms point to biosynthetic processes for surface-related molecules (lipopolysaccharide and poly-hydroxybutyrate) and to cell-surface interactions (receptor clustering, homophilic and heterophilic adhesion). This suggests a theme around bacterial surface component production and adhesion-related functions. Some neuronal morphogenesis terms appear in the list but are less representative of the dominant surface/biosynthesis pattern, so the core signal supports a bacterial surface biogenesis and adhesion label.","confidence":"Medium","size":29,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009103","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0043113","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0007157","count":6}]},{"hash":"431761300464140394","title":"Cardiovascular development and cell cycle","description":"The prominent GO terms show DNA replication and mitotic cell cycle, indicating proliferative activity, while several terms relate to embryonic development of the cranial skeleton and, notably, cardiac neural crest cell development and angiogenesis, which point to heart and vascular formation. Although some immune/response terms appear, the dominant theme is cell proliferation coupled with embryonic cardiovascular development, suggesting proteins involved in growth and heart/vasculature formation.","confidence":"Medium","size":29,"edges":97,"triangles":136,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":29},{"id":"GO:0048701","count":27},{"id":"GO:0000278","count":27},{"id":"GO:0033129","count":26},{"id":"GO:0090606","count":26}]},{"hash":"567845883341625706","title":"RNA Processing and Translational Control","description":"The cluster is strongly enriched for post-transcriptional processes: mRNA splicing via the spliceosome, mRNA export and stabilization, formation of the translation preinitiation complex, translation reinitiation, and miRNA-mediated silencing, indicating a cohesive group of proteins coordinating RNA processing with translational regulation.","confidence":"High","size":29,"edges":396,"triangles":3394,"max_degree":28,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":19},{"id":"GO:0048026","count":15},{"id":"GO:0031047","count":15},{"id":"GO:0001731","count":14},{"id":"GO:0002188","count":14}]},{"hash":"1324513352356513172","title":"Spliceosome-Mediated Splicing Regulation and mRNA Stability","description":"The top GO terms cluster around regulation of mRNA splicing via the spliceosome (positive and negative), alternative splicing, splice site recognition, and also include mRNA export and stabilization, with a stress-related mRNA stability term. This points to a cohesive module of proteins involved in RNA processing and post-transcriptional control of mRNA fate, centered on spliceosome function and mRNA stability. ","confidence":"High","size":29,"edges":170,"triangles":534,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":16},{"id":"GO:0048025","count":13},{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:0006378","count":12}]},{"hash":"731778112254470069","title":"Ribosome biogenesis and nucleocytoplasmic transport","description":"Dominant GO terms point to ribosome assembly and export of ribosomal subunits from the nucleus, plus related nucleocytoplasmic transport (nuclear import/export, mRNA export). The cluster also includes related cell-cycle related localization, suggesting coordination with mitosis, but the strongest signal is ribosome biogenesis and ribosomal subunit export. ","confidence":"High","size":29,"edges":371,"triangles":3059,"max_degree":28,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0000056","count":4},{"id":"GO:0006656","count":4},{"id":"GO:0000122","count":4}]},{"hash":"554155567667078070","title":"Oxidative Stress and Adipogenesis Regulation","description":"The top GO terms cluster around cellular oxidant detoxification and redox homeostasis, paired with triglyceride metabolism and fat cell differentiation, as well as PI3K/AKT signaling modulation and myotube differentiation. This suggests a theme of redox-regulated metabolic control and differentiation programs in adipose and muscle tissues. Some terms, like sensory perception of sound, appear as noise and do not fit the core theme.","confidence":"Medium","size":29,"edges":400,"triangles":3502,"max_degree":28,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":20},{"id":"GO:0045454","count":12},{"id":"GO:0006641","count":9},{"id":"GO:0030416","count":9},{"id":"GO:0033194","count":8}]},{"hash":"1008950998595317834","title":"DNA replication and repair with transcription regulation","description":"Most of the top GO terms center on DNA-templated processes (transcription and replication) and genome maintenance (DNA replication, DNA repair, replication-born DSB repair via SCE, and telomere chromosome localization). A few terms point to development or metabolism that seem less connected (egg chamber stalk formation, ossification, dATP catabolism, fibroblast apoptotic regulation), likely noise. Overall, the cluster is best described by DNA replication/repair with transcription-related activity. ","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:2000271","count":5},{"id":"GO:0006355","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0006351","count":3},{"id":"GO:1990414","count":3}]},{"hash":"484564263764766503","title":"Rho-regulated angiogenesis and cell migration","description":"This cluster is dominated by GO terms for regulation of Rho signaling, angiogenesis, and cell migration, pointing to a core theme of cytoskeletal control driving vascular development and tissue movement. Additional terms related to JUN phosphorylation, GM-CSF\u2013mediated signaling, apoptosis execution, and NK T cell differentiation suggest broader signaling and immune-related connections, but the strongest shared thread is guidance of cell movement and vessel formation via Rho-pathway regulation. The diverse signals present make the cluster cohesive but not tightly co-regulated, hence a Medium confidence.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0060709","count":3},{"id":"GO:2001275","count":3}]},{"hash":"960054961064766541","title":"Developmental Epigenetic Regulation","description":"Genes in this cluster highlight histone modifications (H3K27me3, H3K4me3), DNA methylation-related regulation, and development-related processes such as male gonad development, distal tubule morphogenesis, and pro-T cell differentiation, suggesting epigenetic control of development.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0008584","count":8},{"id":"GO:1900477","count":7},{"id":"GO:0010216","count":6},{"id":"GO:0098532","count":5},{"id":"GO:0051225","count":5}]},{"hash":"2006708256927017653","title":"Telomere Maintenance and PARP Regulation","description":"The top GO terms cluster around telomere maintenance (including telomerase regulation, telomere capping, and general telomere maintenance regulation) and ADP-ribosylation/PARP activity, pointing to roles in telomere stability and DNA damage response. While some terms touch on spindle assembly, Wnt signaling, or synaptic regulation, these are less represented, making telomere-PARP biology the most representative theme for this cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":7},{"id":"GO:0051225","count":7},{"id":"GO:0032212","count":6},{"id":"GO:0070212","count":6},{"id":"GO:1904355","count":6}]},{"hash":"452639480018912987","title":"Multisystem Development and Morphogenesis","description":"The top GO terms span development and morphogenesis across multiple tissues\u2014midbrain morphogenesis, myelination in the peripheral nervous system, hair follicle maturation, heart development, and sensory perception\u2014plus related cytoskeletal dynamics like filopodium assembly. This suggests a cluster centered on developmental processes across organs rather than a single pathway, hence a multisystem development label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0051489","count":3},{"id":"GO:0070493","count":3},{"id":"GO:0048820","count":3},{"id":"GO:0001812","count":3}]},{"hash":"182598401026912429","title":"Rho/Ras signaling and lamellipodium formation","description":"The proteins are enriched for regulation of Rho and Ras signaling, lamellipodium assembly, and cell migration, with supporting terms in innate immune response and insulin signaling. This points to a core theme of cytoskeletal signaling driving cell movement, making 'Rho/Ras signaling and lamellipodium formation' a representative label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0046580","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0006886","count":4},{"id":"GO:0007507","count":3}]},{"hash":"231272406922197198","title":"Axon guidance and myelination with innate signaling","description":"The cluster is enriched for neural development terms: axon guidance, axonogenesis, and myelination, plus Roundabout signaling, aligning with neural pathway development. Immune-related terms (innate immune response, Fc-epsilon receptor signaling) and ubiquitination suggest concurrent signaling and protein regulation, indicating a mix of neural development with immune/ regulatory connections rather than a single narrow function. Confidence in this label is medium due to the mixed signal and lack of a tight, unified function.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":11},{"id":"GO:0016567","count":8},{"id":"GO:0051092","count":7},{"id":"GO:0038095","count":7},{"id":"GO:0007411","count":7}]},{"hash":"785809241251956693","title":"Developmental organogenesis and transcription regulation","description":"This cluster centers on broad developmental and organogenesis processes across multiple tissues (retina, pituitary, pancreas, lung, bone, neural crest, ureteric branching) and on regulation of gene expression by RNA polymerase II, suggesting coordinated developmental programs and transcriptional control during organ formation.","confidence":"High","size":29,"edges":403,"triangles":3575,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":15},{"id":"GO:0002087","count":12},{"id":"GO:0060041","count":12},{"id":"GO:0002076","count":11},{"id":"GO:0031018","count":10}]},{"hash":"708003125052716917","title":"Dendritic Spine Morphogenesis and Synapse Assembly","description":"This cluster is dominated by neuronal development processes: dendritic spine morphogenesis, ephrin receptor signaling, regulation of Rho signaling, and positive regulation of synapse assembly. These terms point to cytoskeletal remodeling and synaptic connectivity in neurons, with ubiquitination indicating broader signaling regulation. Though a few terms relate to other lineages, the strongest signal is neuronal spine formation and synapse wiring.","confidence":"High","size":29,"edges":249,"triangles":1324,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060997","count":7},{"id":"GO:0048013","count":7},{"id":"GO:0071260","count":6},{"id":"GO:0045648","count":6},{"id":"GO:0034446","count":6}]},{"hash":"1542189384607611725","title":"Immune-vascular signaling and angiogenesis","description":"Prominent terms show adaptive immune response, complement activation, and responses to fungal origin, alongside vascular and endothelial processes such as angiogenesis, endothelial cell migration, and PDGF receptor signaling, all connected through ERK pathway and receptor tyrosine kinase activation. This points to a cohesive cluster where immune signaling interfaces with vascular remodeling and endothelial signaling. CNS development and mechanical stimulus responses add developmental and tissue-dynamics context but align with the vascular-immune theme.","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002250","count":14},{"id":"GO:0070374","count":14},{"id":"GO:0001525","count":13},{"id":"GO:0001867","count":13},{"id":"GO:0043536","count":13}]},{"hash":"1307517695197032421","title":"Mitotic Regulation and Spindle Assembly","description":"This cluster centers on mitotic cell cycle and cell division, with strong representation for mitotic spindle assembly and APC/C-dependent proteolysis (K11-linked ubiquitination), indicating coordinated control of chromosome segregation during mitosis. Transcription-related GO term presence may reflect nuclear-phase co-functions but is secondary. Overall, the set likely represents a mitosis-focused module.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0090307","count":4}]},{"hash":"338485017721007674","title":"Redox Homeostasis and Nucleotide Metabolism","description":"The top GO terms point to cellular redox balance (oxidation-reduction and redox homeostasis) along with multiple nucleotide/nucleobase metabolic processes (cytidine, guanine, uridine, cytosine) and related biosynthesis. This suggests a cluster of proteins involved in maintaining redox state and supporting nucleotide metabolism, with some noise from unrelated terms. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:1903206","count":8},{"id":"GO:0045454","count":8},{"id":"GO:0009972","count":7},{"id":"GO:0030091","count":6}]},{"hash":"1147925425261410103","title":"Synapse Organization and Rho Signaling","description":"This cluster centers on synaptic components and organization, including receptor localization/clustering, spine morphogenesis, and synapse maintenance, powered by Rho signaling and cytoskeletal dynamics. A few terms about behavior or barrier function likely reflect broader neuronal roles rather than a dedicated module.","confidence":"High","size":29,"edges":16,"triangles":0,"max_degree":6,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007266","count":26},{"id":"GO:0070433","count":26},{"id":"GO:0060997","count":26},{"id":"GO:0071625","count":26},{"id":"GO:0008285","count":26}]},{"hash":"1900175025319291103","title":"Steroid and Prostaglandin Biosynthesis with Growth Signaling","description":"These GO terms point to biosynthesis of lipid signaling molecules\u2014prostaglandins and androgens (testosterone)\u2014along with growth and regeneration processes (regulation of growth, organ regeneration). The involvement of immune-related regulation (neutrophil aggregation) and muscle/calcium signaling further supports a theme where lipid hormone signaling modulates inflammation, tissue remodeling, and muscle function. Overall, the cluster seems centered on steroid/prostaglandin biosynthesis and its downstream growth/repair signaling pathways.","confidence":"Medium","size":29,"edges":31,"triangles":8,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001516","count":4},{"id":"GO:0008209","count":4},{"id":"GO:0061370","count":4},{"id":"GO:0035726","count":3},{"id":"GO:0043200","count":3}]},{"hash":"865371194683878862","title":"Cerebellar development and MAPK signaling","description":"The top GO terms cluster around cerebellar development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) and signaling pathway regulation (notably ERK/MAPK cascade and insulin signaling), suggesting a module of neural development in the cerebellum with modulation of MAPK signaling. An immune signaling term is less central but the dominant theme is neural development tied to MAPK pathway regulation.","confidence":"Medium","size":29,"edges":403,"triangles":3576,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":25},{"id":"GO:0000200","count":25},{"id":"GO:0070373","count":25},{"id":"GO:0008286","count":17},{"id":"GO:0021697","count":17}]},{"hash":"1515797558168806427","title":"Neuronal gene expression and ribosome biogenesis","description":"The cluster combines core nuclear processes (DNA-templated transcription, mRNA splicing, and rRNA maturation) with neural-context terms (forebrain development, cellular response to dopamine, and regulation of postsynaptic potential). These items together point to a group involved in fundamental gene expression machinery, with a notable emphasis on neuronal development and signaling. Confidence: Medium","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0050830","count":5},{"id":"GO:0090394","count":4},{"id":"GO:0000398","count":4}]},{"hash":"1069579447984871243","title":"Adaptive immune activation and antibody production","description":"This cluster is dominated by adaptive immune functions: immunoglobulin production, T and B cell activation and proliferation (including costimulation and IL-2 signaling), and classical complement activation, with additional roles in immune cell adhesion and NK cell regulation. Taken together, the proteins mainly reflect humoral and cellular adaptive immunity rather than other processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0002377","count":6},{"id":"GO:0042102","count":6},{"id":"GO:0031295","count":6}]},{"hash":"1830774384964988167","title":"Immune activation and cytokine signaling","description":"Top terms indicate immune cell activation (T and B cells), cytokine production (IL-2), and pathogen sensing (peptidoglycan), suggesting proteins involved in immune response regulation. A few terms relate to proteolysis or host\u2013symbiont interactions and ion channel/cardiac functions, which may be ancillary. Overall, the cluster appears driven by immune signaling activities.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:2000649","count":7},{"id":"GO:0042102","count":6},{"id":"GO:0006508","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0002859","count":4}]},{"hash":"1178684320632115953","title":"Cell growth and division regulation","description":"The top GO terms cluster around growth signaling (growth hormone receptor signaling, Wnt pathway), mitotic/spindle processes, and actin cytoskeleton dynamics, all pointing to regulation of cell growth and division. Additional terms touch on development, telomere maintenance, and chromatin-related regulation (ubiquitination, histone methylation), suggesting a broader theme of coordinating growth, division, and genome integrity. Overall, this cluster seems to represent proteins involved in growth control, cell cycle progression, and cytoskeletal remodeling, with ancillary chromatin regulation roles.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060396","count":6},{"id":"GO:0051225","count":6},{"id":"GO:0008585","count":5},{"id":"GO:0030042","count":5},{"id":"GO:0051017","count":5}]},{"hash":"1896058932649489673","title":"Mesodermal and cardiovascular development","description":"The cluster is enriched for mesoderm- and heart-related processes (notochord morphogenesis, heart development, paraxial mesoderm, coronary vasculature development) with supporting embryonic-development terms like neural tube closure and mesodermal differentiation, suggesting a cohesive role in mesoderm-derived organogenesis; a single outlier term may reflect annotation noise.","confidence":"High","size":29,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048570","count":5},{"id":"GO:0007507","count":4},{"id":"GO:0009234","count":4},{"id":"GO:2000324","count":4},{"id":"GO:0048333","count":4}]},{"hash":"27338184310610146","title":"Unknown","description":"The top GO terms show a mix of chromatin/chromosome-related processes, developmental pathways (muscle and brain regions), cytoskeleton, metabolism, and mitochondrial inheritance, with no single cohesive function linking the proteins. Some terms are obsolete, suggesting annotation noise. ","confidence":"","size":29,"edges":52,"triangles":32,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0006348","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0019433","count":4}]},{"hash":"146854317039391765","title":"Embryonic Development and Morphogenesis","description":"The terms point to broad embryonic development and tissue morphogenesis (palate, placenta, mesoderm, EMT-related transitions, cartilage), suggesting these proteins collaborate in early patterning and morphogenetic processes.","confidence":"High","size":29,"edges":41,"triangles":0,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":16},{"id":"GO:0060972","count":16},{"id":"GO:0060707","count":16},{"id":"GO:0060806","count":16},{"id":"GO:0035270","count":16}]},{"hash":"87363544378491824","title":"Vertebrate embryonic organogenesis and neural development","description":"The cluster's GO terms center on developmental processes across multiple tissues (pituitary, pancreas, midbrain, habenula, mouth roof, outflow tract, cartilage, PNS neurons), indicating a shared theme of vertebrate embryogenesis and organogenesis with neural development involvement.","confidence":"High","size":29,"edges":24,"triangles":1,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":10},{"id":"GO:0000122","count":9},{"id":"GO:0031018","count":7},{"id":"GO:0021986","count":7},{"id":"GO:0060021","count":7}]},{"hash":"711223306554872054","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":5},{"id":"GO:0006261","count":5},{"id":"GO:0000467","count":4},{"id":"GO:0000289","count":4},{"id":"GO:0034415","count":4}]},{"hash":"569196410890005624","title":"Endothelial barrier regulation and innate immunity","description":"The cluster\u2019s top GO terms point to inflammatory signaling and vascular permeability (positive regulation of endothelial barrier establishment, response to LPS, IL-1\u03b2 production, IL-8 regulation), along with innate immune actions (neutrophil-mediated killing of gram-positive bacteria) and tissue remodeling (elastin catabolic process). While a term like amelogenesis is less directly linked, the overall pattern centers on inflammation, barrier regulation, and innate immune responses.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:1903142","count":13},{"id":"GO:0032496","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0097186","count":10},{"id":"GO:0060309","count":10}]},{"hash":"2168093266297550463","title":"Developmental Morphogenesis","description":"This cluster centers on morphogenesis across tissues (lens fiber, hair follicle, neural axon fasciculation) and developmental processes (multicellular organism development, EMT in heart formation). Signaling terms like Rac and MAPK point to regulatory pathways that shape these morphogenetic events, suggesting a cohesive theme of tissue/organ morphogenesis during development.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0000161","count":3},{"id":"GO:0070309","count":3},{"id":"GO:0071372","count":3}]},{"hash":"1439772551475832466","title":"Innate Immune Signaling and Defense","description":"This cluster is dominated by GO terms for innate immune response, macrophage activation, TLR signaling, response to dsRNA, and defense against Gram-positive bacteria, indicating proteins functioning in innate immune sensing and antimicrobial defense. A few terms related to collagen/meristem/brassinosteroid are present but appear as non-core annotations, so the main theme remains immune-related rather than structural or plant-specific.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0060348","count":4},{"id":"GO:0030199","count":3},{"id":"GO:0009934","count":3},{"id":"GO:0090141","count":3}]},{"hash":"972989375684468798","title":"Neural myelination and sensory signaling with cardiac/immune links","description":"This cluster is dominated by neural-related terms (myelination, sensory perception of sound, dopamine signaling) but also includes cardiac electrophysiology (regulation of ventricular repolarization, heart rate) and immune-related terms (innate immune response, T cell costimulation), suggesting a neural-centric cluster with secondary cardiac and immune associations.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0007605","count":3},{"id":"GO:0009636","count":3},{"id":"GO:2000649","count":2},{"id":"GO:0060307","count":2}]},{"hash":"1287704505565457851","title":"Developmental cell adhesion and immune processes","description":"The top GO terms show a strong focus on cell-cell adhesion (heterophilic, homophilic, general adhesion) together with development-related processes (nervous system development, synapse assembly, salivary gland branching, ossification). Additional terms point to innate immunity and complement activation, and a host\u2013cell interaction term (symbiont entry into host cell), suggesting a cluster of adhesion-related proteins that participate in tissue development and immune interfaces. Overall, the functions cohere around adhesion-driven development with immune/interfacial roles.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0043931","count":15},{"id":"GO:0006958","count":13},{"id":"GO:0007399","count":11},{"id":"GO:0007155","count":11}]},{"hash":"2024854062463772333","title":"Embryonic heart, neural, and vascular development","description":"The cluster is enriched in developmental and morphogenesis terms spanning heart development, retina layer formation, myoblast fusion, angiogenesis, vascular branching, and bone maturation, plus neural signaling processes like neurotransmitter secretion and regulation of synaptic vesicle endocytosis. This points to a cohesive theme of embryonic tissue development and morphogenesis across heart, muscle, vasculature, and neural tissues, with some neural signaling components. Therefore, a label capturing broad embryonic development across these tissues fits well.","confidence":"High","size":28,"edges":19,"triangles":2,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0010842","count":10},{"id":"GO:0007520","count":10},{"id":"GO:1900242","count":10},{"id":"GO:0001525","count":9}]},{"hash":"2093362708018564126","title":"Neuronal GPCR-Dopaminergic Signaling","description":"The cluster centers on neuronal signaling pathways: membrane potential regulation, adenylate cyclase-coupled GPCR signaling, and neuropeptide signaling, with substantial representation of dopaminergic synaptic transmission and ERK cascade modulation. Additional terms related to temperature/pain perception and brain renin-angiotensin signaling reinforce a CNS-focused signaling module governing neuronal excitability and sensory processing.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":16},{"id":"GO:0010579","count":15},{"id":"GO:0007218","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0002024","count":15}]},{"hash":"793757464688265535","title":"Connective Tissue Development","description":"Based on the GO terms, the dominant themes are extracellular matrix organization and development of connective tissues and organs (collagen fibril organization, cartilage condensation, lung connective tissue development, metanephric glomerulus development, nipple morphogenesis). Immune-related terms are present but secondary. This suggests a developmental, connective-tissue\u2013focused cluster.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0001502","count":6},{"id":"GO:0043330","count":5},{"id":"GO:0050830","count":5},{"id":"GO:1903351","count":5}]},{"hash":"518879348380019075","title":"Transcription-Driven Differentiation and Metabolic Signaling","description":"This cluster centers on transcriptional regulation (DNA-templated transcription and nuclear receptor signaling) linked to differentiation programs across fat cells, chondroblasts, and macrophages, with metabolic signaling in insulin-responsive pathways. The GO terms point to a theme where transcriptional control mediates both differentiation and metabolic responses.","confidence":"Medium","size":28,"edges":155,"triangles":217,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":17},{"id":"GO:0045444","count":16},{"id":"GO:2001275","count":16},{"id":"GO:0010745","count":16},{"id":"GO:0006351","count":16}]},{"hash":"1843651945915802072","title":"COPI-mediated ER-Golgi trafficking","description":"The terms strongly point to ER-to-Golgi transport and COPI vesicle dynamics (COPI-coated vesicles, vesicle budding, positive regulation of protein exit from ER, ER lumen retention) and related secretion processes (Wnt protein secretion), with some axis specification terms reflecting downstream developmental signaling. This indicates a cohesive theme centered on the secretory pathway and vesicle trafficking.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0002121","count":6},{"id":"GO:0007311","count":6},{"id":"GO:0032525","count":6},{"id":"GO:0006888","count":6},{"id":"GO:1902003","count":6}]},{"hash":"31392500387977568","title":"Unknown","description":"The GO terms cover a wide range of processes\u2014from DNA replication regulation and chemotherapy response to intracellular transport, mitochondrial inheritance, signaling pathways (Rap and NF-kappaB), immune cell aggregation, neural development, and cell fusion\u2014showing no single cohesive function. Therefore no concise, representative label can be assigned.","confidence":"","size":28,"edges":88,"triangles":22,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045740","count":13},{"id":"GO:0097327","count":12},{"id":"GO:0048227","count":12},{"id":"GO:0000001","count":12},{"id":"GO:0045859","count":12}]},{"hash":"892398378296629316","title":"Vertebrate Development and Immune Defense","description":"The cluster centers on developmental processes\u2014midbrain and pituitary development, multicellular organism development, and growth\u2014with supporting signaling (Wnt pathway) and broad transcription regulation, plus immune-related processes (response to lipopolysaccharide, defense against Gram-positive bacteria, complement activation, and blood coagulation). This suggests a broad vertebrate developmental program intertwined with innate immune and coagulation functions, rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0016055","count":8},{"id":"GO:0032496","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0021983","count":7}]},{"hash":"1599563078061691377","title":"Neuronal Signaling and Synaptic Plasticity","description":"The cluster is dominated by GO terms related to neural communication and plasticity: excitatory and inhibitory synaptic signaling (EPSP and GABA pathway), ion transport through sodium/potassium channels, receptor internalization, and regulation of long-term synaptic plasticity, plus behavior-linked terms like locomotion and conditioned taste aversion, all pointing to a cohesive theme of neuronal signaling and experience-dependent plasticity, including responses to ethanol.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":26},{"id":"GO:0001661","count":25},{"id":"GO:0071805","count":25},{"id":"GO:0007626","count":25},{"id":"GO:0007214","count":25}]},{"hash":"810821168991457588","title":"Unknown","description":"The top GO terms span redox processes, platelet aggregation, neuron migration, plant morphogenesis, miRNA silencing, actin regulation, and various developmental and signaling pathways, across different species. There isn\u2019t a single coherent function or theme tying these proteins together, so no meaningful label can be assigned beyond Unknown.","confidence":"","size":28,"edges":36,"triangles":11,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":12},{"id":"GO:0070527","count":8},{"id":"GO:0097477","count":8},{"id":"GO:0042619","count":8},{"id":"GO:2000637","count":7}]},{"hash":"1175469371645755880","title":"Embryonic Morphogenesis and Organogenesis","description":"This cluster is enriched for GO terms describing embryonic development, including palate formation, left/right patterning, endocardial cushion EMT, cartilage morphogenesis, placenta and endocrine organ development, and specific tissue lineages such as pancreatic beta cells. The presence of transcriptional regulation terms (RNA polymerase II activity and its negative regulation) suggests coordinated gene expression control during organogenesis.","confidence":"High","size":28,"edges":92,"triangles":37,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":27},{"id":"GO:0000122","count":24},{"id":"GO:0006366","count":20},{"id":"GO:0060972","count":17},{"id":"GO:0003198","count":17}]},{"hash":"1305990739296497465","title":"Hemostasis, fibrinolysis, and vascular remodeling","description":"The top GO terms cluster around blood coagulation and fibrinolysis, along with regulatory effects on angiogenesis, platelet aggregation, and collagen/ECM remodeling, plus associated proteolysis. This combination points to a program of hemostasis coupled with vascular remodeling rather than a single isolated function, making this a coherent label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":7},{"id":"GO:0045766","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0014068","count":5},{"id":"GO:0006508","count":5}]},{"hash":"507899438887460724","title":"Dopaminergic neural signaling and appetite regulation","description":"The cluster shows strong enrichment for dopaminergic synaptic transmission, GPCR-activated cAMP signaling, and regulation of feeding behavior and appetite, suggesting a brain-centered module of neural signaling and behavioral control. Sensory processing terms (pain and vision) along with grooming behavior further support a neural circuitry theme, while the electron transport chain and heart-related terms may reflect neuronal energy needs or broader systemic associations. Overall, the dominant signal points to dopaminergic signaling and behavioral regulation in the brain.","confidence":"Medium","size":28,"edges":51,"triangles":2,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":21},{"id":"GO:0045777","count":21},{"id":"GO:0001963","count":20},{"id":"GO:0007507","count":20},{"id":"GO:0007601","count":20}]},{"hash":"895193390332726628","title":"Intracellular Transport and Signaling","description":"This cluster is dominated by GO terms for intracellular protein transport and various signaling/regulatory processes (e.g., GTPase activity regulation, phosphatidylinositol signaling, SMAD signaling). These points suggest proteins involved in trafficking within the cell and modulation of signal transduction, rather than a single tissue-specific function. A few terms touch on muscle development or visual perception, indicating broader roles, but the core theme appears to be transport plus signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0035690","count":3}]},{"hash":"1335929744998885748","title":"Developmental fate specification and chromatin regulation","description":"The top GO terms cluster around developmental processes and cell fate decisions (hair follicle placode formation, glial cell fate determination, maintenance of organ identity) and are supported by chromatin-related regulation (transcription initiation-coupled chromatin remodeling). While a few terms touch on general cellular processes (vacuole inheritance, apoptosis), the overall signal points to proteins coordinating developmental specification through chromatin-mediated gene regulation.","confidence":"Medium","size":28,"edges":14,"triangles":3,"max_degree":6,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0071681","count":12},{"id":"GO:0048496","count":12},{"id":"GO:0060789","count":12},{"id":"GO:0007403","count":12},{"id":"GO:0051561","count":12}]},{"hash":"409878586520960094","title":"ECM Collagen Assembly and Integrin-BMP Signaling","description":"The cluster is dominated by terms for collagen fibril organization, collagen biosynthesis, and ECM-related signaling, including integrin-mediated and BMP-responsive pathways, plus VEGF signaling and chondrocyte differentiation regulation. This points to connective tissue remodeling, cartilage/bone development, and associated angiogenic signaling, with calcium- and PI3K/AKT\u2013related signaling interplays. A few terms like neuron migration regulation are peripheral but do not override the core ECM/development theme.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070886","count":6},{"id":"GO:0030199","count":6},{"id":"GO:0007229","count":6},{"id":"GO:0071773","count":6},{"id":"GO:0032331","count":6}]},{"hash":"1165959493032931670","title":"Intestinal brush border cytoskeleton and tight junctions","description":"The top terms cluster around the brush border and epithelial junctions: microvillus length regulation, actomyosin organization, terminal web assembly, and bicellular tight junction assembly, along with intestinal glucose absorption. This points to a cohesive module governing cytoskeletal structure and barrier function in intestinal enterocytes, despite a few unrelated terms like translation initiation appearing in the mix. ","confidence":"High","size":28,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1902896","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0001951","count":4},{"id":"GO:0070830","count":4},{"id":"GO:0032532","count":4}]},{"hash":"92409140343378262","title":"Ion transport and membrane potential regulation","description":"This cluster centers on establishing or maintaining transmembrane electrochemical gradients and ion transport (sodium/potassium), along with general transmembrane transport and membrane potential regulation. While a few terms touch on neuronal or hepatic contexts, the dominant GO terms point to ion movement and electroneutral/excitable membrane function, suggesting a cohesive theme of membrane potential control.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010248","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0097284","count":2}]},{"hash":"1329005109701130669","title":"RNA processing and post-transcriptional regulation","description":"The top GO terms point to a tight cluster of post-transcriptional control mechanisms: mRNA splicing and spliceosome activity, mRNA stability and export, regulation of alternative splicing, polyadenylation, and RNA silencing via miRNA, plus components of translation initiation. This coherent set indicates a module focused on RNA-level processing and gene expression control after transcription, hence the label.","confidence":"High","size":28,"edges":282,"triangles":1552,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":18},{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0000381","count":16},{"id":"GO:0006378","count":15}]},{"hash":"1777587248365191262","title":"Transmembrane Solute Transporters","description":"The top GO terms all point to transport across membranes for various substrates\u2014ions, sugars, xenobiotics, and related neurotransmitter loading. The diversity of substrates suggests these proteins act as transporters rather than signaling or metabolic enzymes, capturing a general transporter function across multiple substrates.","confidence":"High","size":28,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":13},{"id":"GO:0015751","count":13},{"id":"GO:0006855","count":13},{"id":"GO:0042891","count":13},{"id":"GO:0015706","count":13}]},{"hash":"677412175457152980","title":"GPCR-GTPase Signaling and Cytoskeletal Remodeling","description":"The cluster centers on signaling pathways that regulate cytoskeletal dynamics and vesicle exocytosis, highlighted by GPCR signaling and GTPase activity terms, calcium-dependent exocytosis, and filopodium-related processes. The presence of GABAergic synaptic transmission, acrosome reaction, and heart development suggests these signals act across diverse contexts (neuronal, reproductive, and developmental) to control cell movement, adhesion, and secretion. This cohesive theme makes a specific, intuitive label appropriate, though some terms reflect specialized contexts.","confidence":"Medium","size":28,"edges":6,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0007205","count":5},{"id":"GO:0051932","count":5},{"id":"GO:0045956","count":5}]},{"hash":"1544346240399316871","title":"GPCR-cAMP signaling in nervous and cardiovascular biology","description":"The top GO terms point to GPCR signaling that activates adenylate cyclase, with downstream effects on cAMP, plus dopaminergic synaptic transmission, and sensory processes (vision and pain) as well as cardiovascular-related development and blood pressure. Prostaglandin response and energy-related terms (electron transport chain) suggest broader cellular signaling and metabolism, but the dominant theme is GPCR-cAMP signaling linked to neural sensory functions and cardiovascular regulation. Confidence: High","confidence":"","size":28,"edges":23,"triangles":1,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0007190","count":14},{"id":"GO:0071380","count":12}]},{"hash":"138170247262863803","title":"Redox Homeostasis and Metabolic Biosynthesis","description":"The top GO terms cluster around maintaining redox balance (cell redox homeostasis, oxidation-reduction) and basic metabolic biosynthesis (L-glutamate and guanine metabolism, camphor catabolism), suggesting a group of proteins involved in core metabolic and redox-related functions. Some terms are obsolete or less clearly connected (e.g., neural precursor proliferation), which may reflect cross-species annotations or pleiotropic roles, but the central theme appears to be redox regulation coupled with metabolic processes.","confidence":"Medium","size":28,"edges":197,"triangles":636,"max_degree":25,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":18},{"id":"GO:0055114","count":16},{"id":"GO:0043046","count":16},{"id":"GO:0045793","count":16},{"id":"GO:0051572","count":15}]},{"hash":"2275397400173243785","title":"Immune signaling and cytoskeletal remodeling","description":"This cluster is enriched for innate and adaptive immune response terms, plus processes tied to cytoskeleton and membrane dynamics (Rho signaling, actin cortical patch assembly, endocytosis) and cell adhesion, which together suggest a group of proteins involved in immune cell activation, trafficking, and interactions. The presence of IL-2 production and apoptotic processes further supports immune-related signaling with dynamic cytoskeletal remodeling. A few terms like heart development are less directly tied but may reflect shared developmental pathways or annotations. Overall, the common theme is immune signaling intertwined with cytoskeletal dynamics.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0002250","count":8},{"id":"GO:0006915","count":7},{"id":"GO:0000147","count":7}]},{"hash":"2063704552325380056","title":"Post-transcriptional mRNA processing and regulation","description":"The proteins cluster around multiple post-transcriptional steps: splicing and splice-site recognition, mRNA export, polyadenylation, mRNA stability control, and miRNA/regulatory ncRNA\u2013mediated silencing, plus translation initiation complex formation. This points to a coherent role in mRNA maturation and regulation of translation, rather than transcriptional control.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":25},{"id":"GO:0006378","count":19},{"id":"GO:0045292","count":18},{"id":"GO:0006376","count":17},{"id":"GO:0006406","count":17}]},{"hash":"682142956487326184","title":"Neuronal signaling and cytoskeletal remodeling","description":"The top GO terms emphasize Rho-regulated signaling, phosphatidylinositol signaling, actin cytoskeleton dynamics, and synaptic plasticity (LTP/LTD), along with substantia nigra development, suggesting a neuronal-focused module centered on signaling plus cytoskeletal remodeling. Some terms (heart development, sperm capacitation) are less consistent but do not override the dominant neural theme. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0048015","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0031532","count":3},{"id":"GO:0007507","count":3}]},{"hash":"412718211252005434","title":"Developmental signaling and vesicle trafficking","description":"The cluster includes terms tied to developmental signaling (kidney and nervous system development; Hedgehog via Smoothened; Roundabout/axon guidance) alongside vesicle trafficking processes (endocytosis, synaptic vesicle exocytosis, multivesicular body-related regulation). This suggests a cohesive theme of signaling regulation tightly linked to membrane trafficking across developmental and neural contexts, with some immune signaling context as well. ","confidence":"Medium","size":28,"edges":169,"triangles":284,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":8},{"id":"GO:0007224","count":7},{"id":"GO:0035385","count":6},{"id":"GO:0050852","count":6},{"id":"GO:2000300","count":6}]},{"hash":"1094269615358354690","title":"Cell cycle control and transcription regulation","description":"The top GO terms cluster around the G1/S transition of the mitotic cell cycle, regulation of the cell cycle, CDK activity, and DNA-templated transcription, indicating proteins involved in cell-cycle control and transcriptional regulation. Some development-related terms (mammary gland alveolus development, Leydig cell differentiation) may reflect broader differentiation roles, but the dominant signal is cell-cycle regulation and transcriptional control.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":13},{"id":"GO:0071157","count":11},{"id":"GO:0033327","count":11},{"id":"GO:0045737","count":11},{"id":"GO:0006351","count":11}]},{"hash":"1191191544018894613","title":"Broad developmental differentiation across tissues","description":"The top GO terms cluster around tissue- and organ-specific development (labyrinthine layer, spongiotrophoblast, wing and cone cell fate, spermatid differentiation) along with related proliferation and signaling (EGFR regulation). This pattern suggests a broad theme of development and cell fate specification across diverse tissues rather than a single, cohesive pathway. Confidence: Medium","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060711","count":2},{"id":"GO:0060712","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0035311","count":2},{"id":"GO:0042058","count":2}]},{"hash":"408973947494338696","title":"Developmental patterning and organogenesis regulators","description":"The cluster shows a broad enrichment for embryonic development across multiple tissues, with neural patterning (floor plate, subpallium neuron fate, spinal cord motor neuron fate), somitogenesis, and various organogenesis processes (pancreas, bronchiole/lung vasculature, skeletal muscle). The repeated appearance of transcription-related GO term (transcription by RNA polymerase II) suggests these proteins act as transcriptional regulators coordinating fate decisions during development, making this a coherent theme. ","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":23},{"id":"GO:0031018","count":15},{"id":"GO:0001756","count":15},{"id":"GO:0060163","count":14},{"id":"GO:0033504","count":14}]},{"hash":"701491828877490123","title":"Ciliogenesis and GTPase-regulated cytoskeleton remodeling","description":"This cluster links ciliogenesis and multi-ciliated epithelial differentiation with GTPase-driven remodeling of the actin cytoskeleton. The top GO terms emphasize small GTPase signaling, regulation of GTPase activity, actin cytoskeleton organization, and de novo centriole assembly\u2014processes central to cilium formation and basal body\u2013driven epithelial differentiation, with secondary connections to insulin signaling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0048009","count":2},{"id":"GO:0060313","count":2}]},{"hash":"2297482807544590618","title":"Integrin-mediated adhesion and cytoskeleton signaling","description":"The top GO terms converge on regulation of integrin-mediated cell adhesion and Rho\u2013cytoskeleton signaling (including stress fiber assembly), indicating a module focused on adhesion dynamics and cytoskeletal remodeling. Additional terms touch on neuronal synaptic plasticity, angiogenesis, and specialized sensory cell development, which can be linked to adhesion and signaling roles in diverse tissues. Overall, the cluster appears to center on how cells adhere and reorganize their cytoskeleton to modulate signaling during development and tissue remodeling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0033628","count":9},{"id":"GO:0035023","count":8},{"id":"GO:0051497","count":8},{"id":"GO:0051000","count":8},{"id":"GO:0050957","count":8}]},{"hash":"913572229594465314","title":"Neural development and fate specification","description":"Most enriched GO terms describe neural development and diverse neuron/glia fate specification (interneurons, motor neurons, oligodendrocytes) and related transcriptional programs, indicating a cohesive neural differentiation cluster; a second, less dominant term for endocrine pancreas development probably reflects broad developmental roles rather than a primary function here.","confidence":"High","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":23},{"id":"GO:0031018","count":22},{"id":"GO:0060163","count":22},{"id":"GO:0021530","count":22},{"id":"GO:0060435","count":22}]},{"hash":"1827790144875575593","title":"Neural signaling and sensory perception","description":"Based on the top GO terms, the cluster centers on neural signaling, sensory processing, and behavioral responses: dopaminergic synaptic transmission, visual perception/learning, cocaine-related behavioral response, and ERK pathway regulation, which are hallmark brain signaling processes. The presence of terms like heart development and macrophage chemotaxis suggests some cross-talk or pleiotropy, but the dominant theme remains neural signaling and sensory processing. ","confidence":"Medium","size":28,"edges":368,"triangles":3025,"max_degree":27,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":21},{"id":"GO:0019233","count":21},{"id":"GO:0001963","count":20},{"id":"GO:0007601","count":20},{"id":"GO:0006468","count":20}]},{"hash":"698779568761675338","title":"Cytoskeletal remodeling and adhesion signaling","description":"The most represented terms point to cytoskeletal dynamics and cell-matrix interactions: regulation of Rho and ARF signaling, filopodium assembly, and integrin activation, all central to cell movement and adhesion; additional vascular and neutrophil regulation terms are context-dependent but fit within motility/adhesion programs.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":23},{"id":"GO:0046847","count":23},{"id":"GO:0043314","count":22},{"id":"GO:0032012","count":22},{"id":"GO:0033622","count":22}]},{"hash":"576081964277324363","title":"Atrial Electrophysiology and Ion Transport","description":"This cluster is dominated by GO terms related to atrial cardiac muscle cell action potentials, regulation of membrane depolarization, and regulation of heart rate by cardiac conduction, all pointing to proteins involved in atrial electrical activity and ion transport, especially sodium channel regulation. While there are some adhesion and immune-related terms, the core theme centers on atrial electrophysiology and ion transport.","confidence":"High","size":28,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2000649","count":10},{"id":"GO:0007156","count":9},{"id":"GO:0007157","count":9},{"id":"GO:0086091","count":9},{"id":"GO:0086014","count":9}]},{"hash":"1827604539711352008","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":30,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006450","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0090502","count":1}]},{"hash":"463173038558822644","title":"Cell Cycle and Antiviral Innate Responses","description":"Top GO terms emphasize cell division and the mitotic cell cycle (9 hits), suggesting a core theme of cell-cycle\u2013related proteins in this cluster. Additional strong signals for innate immune processes (innate immune response, defense response to virus, cellular response to exogenous dsRNA, interferon-alpha signaling) indicate antiviral roles and possible regulatory cross-talk between cell-cycle control and immune signaling. The presence of non-motile cilium assembly and photoreceptor outer segment localization hints at auxiliary roles in ciliary/retinal biology, potentially as secondary annotations. Overall, the cluster seems to combine cell-cycle machinery with antiviral response components, though the exact functional linkage may be context-dependent.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0000278","count":9},{"id":"GO:0006478","count":8},{"id":"GO:0071360","count":8},{"id":"GO:0045087","count":8}]},{"hash":"2270887852210592568","title":"Macrophage inflammatory signaling and lipid remodeling","description":"The cluster centers on macrophage activation and inflammatory signaling, with frequent GO terms for defense against Gram-positive bacteria, IL-1 production, and leukotriene biosynthesis, plus ERK1/2 cascade involvement. The presence of phospholipid acyl-chain remodeling and phospholipase activity regulation suggests concurrent membrane lipid remodeling tied to immune signaling, pointing to macrophage-driven inflammatory responses and lipid mediator production.","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010744","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0045740","count":4},{"id":"GO:0019370","count":4},{"id":"GO:0070374","count":4}]},{"hash":"1883283361693881106","title":"Motor neuron axon guidance and migration","description":"This cluster is dominated by GO terms related to motor neuron development, including motor neuron axon guidance, peripheral nervous system axonogenesis, lateral motor column neuron migration, and cell-matrix adhesion, all of which point to neuronal pathfinding and wiring. Additional terms like detection of muscle stretch and actin filament regulation support neuromuscular connectivity. Some unrelated terms are present, but the neural development signal is the strongest overall.","confidence":"High","size":28,"edges":104,"triangles":62,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007160","count":23},{"id":"GO:0008045","count":23},{"id":"GO:0048936","count":23},{"id":"GO:0097477","count":22},{"id":"GO:0070527","count":22}]},{"hash":"2164244449899773747","title":"Immune signaling and angiogenesis","description":"Based on the top GO terms, the proteins are enriched for defense responses to Gram-positive bacteria, pyroptotic inflammatory response, regulation of NF-kappaB and ERK signaling, and endothelial cell migration/angiogenesis. This points to a theme of immune/inflammatory signaling coupled with vascular remodeling. Some terms (e.g., spermatid development) seem unrelated or misannotated, but the core pattern supports immune signaling linked to angiogenesis.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0050718","count":3},{"id":"GO:0070269","count":3}]},{"hash":"774707231684349706","title":"Mitochondria-driven apoptosis and neural stress response","description":"The top GO terms center on both extrinsic and intrinsic apoptotic signaling and mitochondrial dynamics (MMP regulation and MOMP), plus stress responses (oxidative, salt). Neural-context terms like synaptic vesicle transport and CNS myelin maintenance suggest this cluster reflects mitochondria-mediated apoptosis and neural homeostasis under stress.","confidence":"High","size":28,"edges":27,"triangles":0,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0008625","count":2},{"id":"GO:0010917","count":2},{"id":"GO:0008631","count":2},{"id":"GO:0009651","count":2},{"id":"GO:0002479","count":2}]},{"hash":"2103770654936188061","title":"Cardiac calcium signaling and conduction","description":"The strongest cluster signal centers on calcium handling in cardiac muscle, including release of Ca2+ from the sarcoplasmic reticulum, regulation of ryanodine-sensitive Ca2+ channels, and regulation of cardiac muscle membrane potential and electrical conduction. While a few terms relate to development or immunity, the overarching theme ties to excitation-contraction coupling and cardiac electrical signaling.","confidence":"High","size":28,"edges":7,"triangles":0,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0050832","count":6},{"id":"GO:0006355","count":6},{"id":"GO:0014808","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0010880","count":4}]},{"hash":"2180011462437745196","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006890","count":7},{"id":"GO:0006888","count":7},{"id":"GO:0051301","count":6},{"id":"GO:0038202","count":6},{"id":"GO:0070262","count":6}]},{"hash":"921326652522878548","title":"Adaptive Immune Activation and Iron Transport","description":"The cluster is dominated by GO terms tied to adaptive immunity\u2014positive regulation of T cell activation and cytotoxicity, B cell activation, and T cell cytokine production\u2014alongside iron ion transport/import, suggesting a link between immune activation and iron metabolism within this protein set.","confidence":"High","size":28,"edges":165,"triangles":472,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0010977","count":24},{"id":"GO:0001916","count":24},{"id":"GO:0098711","count":24},{"id":"GO:0050690","count":24},{"id":"GO:0050871","count":24}]},{"hash":"2296613548789431158","title":"Steroid and lipid biosynthesis","description":"This cluster is dominated by GO terms tied to biosynthesis and metabolism of lipids and steroid hormones\u2014glucocorticoids, androgens (testosterone, C21-steroid hormones), sphingolipids, fatty acids, and retinol\u2014suggesting a cohesive function in lipid and steroid production. While a term like PHB biosynthesis appears, the core pattern centers on steroids and lipid pathways, supporting a focused label despite some diverse terms. ","confidence":"Medium","size":28,"edges":185,"triangles":728,"max_degree":23,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":17},{"id":"GO:0055114","count":17},{"id":"GO:0017000","count":16},{"id":"GO:0006704","count":16},{"id":"GO:0008209","count":16}]},{"hash":"1166832258726894066","title":"Cardiovascular Development and Metabolic Regulation","description":"The strongest signals come from cardiovascular-related terms (regulation of blood pressure, heart development) and a metabolic signal (glucose import in response to insulin stimulus), suggesting the cluster centers on heart-related development and insulin-responsive metabolism. Other terms like adhesion and basic nuclear processes appear as weaker, supporting a broad functional mix, but the core theme appears cardiovascular and metabolic. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008217","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0044381","count":2},{"id":"GO:0070267","count":1},{"id":"GO:0007157","count":1}]},{"hash":"274311156430243593","title":"Dopaminergic neural signaling and sensory perception","description":"This cluster is dominated by GO terms related to neural signaling and sensory processing: pain perception, dopaminergic synaptic transmission, cocaine response, visual perception and learning, and temperature/prostglandin/ERK signaling responses. These collectively point to neural signaling roles with sensory integration, even though heart development appears less central. Overall, the core theme is neural signaling and sensory processing.","confidence":"Medium","size":28,"edges":127,"triangles":80,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":21},{"id":"GO:0001963","count":18},{"id":"GO:0007507","count":18},{"id":"GO:0007601","count":18},{"id":"GO:0002024","count":18}]},{"hash":"871549821516580914","title":"Muscle stress\u2013induced transcription and chromatin regulation","description":"The top GO terms point to gene expression control and muscle adaptation under stress\u2014DNA-templated transcription, chromatin binding regulation, and cardiac hypertrophy in response to stress\u2014along with muscle fiber type transitions. Additional terms about deubiquitination and cell-cycle regulation suggest broader control of protein turnover and growth signals during stress. Overall, the cluster seems centered on transcriptional regulation in muscle under stress, despite some noisy or obsolete terms.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0035562","count":4},{"id":"GO:0014883","count":4},{"id":"GO:1904378","count":4},{"id":"GO:0035523","count":4}]},{"hash":"807427402887679736","title":"Unknown","description":"The cluster contains a mix of transcriptional regulation terms, a pancreatic cell development term, and several unrelated metabolic and signaling processes, with no evident shared function linking all proteins (and no edges between them). This lack of cohesive theme supports labeling as Unknown.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0006351","count":3},{"id":"GO:1903026","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060168","count":3}]},{"hash":"1570672914476439941","title":"Ubiquitin-Proteasome Regulation and Signaling","description":"This cluster is dominated by ubiquitin-related functions: ubiquitin-dependent protein catabolic processes, polyubiquitination, SCF-proteasome pathways, and various forms of ubiquitination, plus links to NF-kappaB/TNF signaling and circadian rhythm regulation. Together these terms point to a coherent theme of ubiquitin-mediated protein turnover and signaling regulation, including connections to neuronal stress responses and synaptic organization. Confidence in this label is High.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":21},{"id":"GO:0042752","count":12},{"id":"GO:0000209","count":10},{"id":"GO:0070534","count":9},{"id":"GO:1903378","count":9}]},{"hash":"866907298462327354","title":"Ectodermal epithelial morphogenesis and differentiation","description":"The dominant GO terms point to morphogenesis and differentiation of ectoderm-derived epithelia, notably polarized epithelial differentiation, skin morphogenesis, and eye morphogenesis, with integrin activation linking cell adhesion to tissue shaping. Although other terms (e.g., blood circulation, xenobiotic response) are present, the core signal is ectodermal epithelial development and organization.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008015","count":3},{"id":"GO:0035690","count":2},{"id":"GO:0030859","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0033622","count":2}]},{"hash":"1016223200564054208","title":"Neurite outgrowth and microtubule dynamics","description":"The cluster is dominated by GO terms tied to neuronal process formation (neuron projection development, dendrite morphogenesis) and microtubule dynamics (polymerization, sliding, bundle formation), with additional terms on mitochondrial distribution along microtubules. This points to a cohesive function in neurite extension and cytoskeletal organization, making the label a good fit across the proteins in the set.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0031116","count":4},{"id":"GO:1903748","count":3},{"id":"GO:0048312","count":3},{"id":"GO:0051012","count":3}]},{"hash":"1499313501778846645","title":"Unknown","description":"The top GO terms span unrelated processes\u2014GPCR signaling, cardiac action potential regulation, epithelial polarity, cell migration, multiple apoptotic processes, telomere maintenance, endothelial delamination, NOD2 signaling, and IL-12 regulation\u2014showing no single shared function or theme across the cluster. Therefore there is no coherent label to uniquely capture its biology.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":11},{"id":"GO:0098907","count":11},{"id":"GO:0090162","count":10},{"id":"GO:0016477","count":10},{"id":"GO:0033028","count":10}]},{"hash":"6950068924360599","title":"Neuronal adrenergic and dopaminergic signaling","description":"The top terms center on brain-related signaling pathways: adrenergic receptor signaling, dopaminergic synaptic transmission, brain renin-angiotensin systems, and blood pressure regulation, all pointing to neural neurotransmitter signaling involving adrenergic and dopaminergic systems. Some immune terms appear as collateral signals but the dominant theme is neural catecholaminergic signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":28},{"id":"GO:0001963","count":28},{"id":"GO:1900453","count":28},{"id":"GO:0001994","count":28},{"id":"GO:0071883","count":28}]},{"hash":"734281412111506929","title":"Sensory Perception and Temperature Response","description":"Several top GO terms converge on sensory modalities and temperature sensing, including diet-induced thermogenesis and cellular response to temperature stimulus, as well as visual perception and regulation of opsin-mediated signaling. Calcium release and Rho signaling point to underlying signaling cascades in sensory transduction. Some terms (defense response to bacterium, peptidoglycan/cell wall catabolic processes) are outliers, possibly reflecting multifunctional proteins or annotation noise. Overall, the cluster seems to group proteins involved in sensory perception and temperature-related signaling.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0035025","count":8},{"id":"GO:0042742","count":8}]},{"hash":"113801634583782444","title":"Developmental signaling and cytoskeletal regulation","description":"The cluster shows enrichment for signaling-related GO terms (positive regulation of GTPase activity; positive regulation of protein serine/threonine kinase activity and autophosphorylation), cytoskeletal control (negative regulation of Arp2/3 actin nucleation), and development-associated processes (multicellular organism development, skin development), along with cell cycle and stress response (mitotic cell cycle, cellular response to hypoxia) and mRNA transport. This pattern suggests a coordinated module governing signaling, growth/division, and cytoskeletal remodeling during development. ","confidence":"Medium","size":27,"edges":62,"triangles":71,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0030433","count":8},{"id":"GO:0000278","count":7},{"id":"GO:0007275","count":6},{"id":"GO:0051028","count":6}]},{"hash":"598051886610198713","title":"RNA Pol II Transcription Regulation and Muscle/Heart Differentiation","description":"The cluster is dominated by RNA polymerase II\u2013related transcription terms (DNA-templated transcription, initiation, preinitiation complex assembly) with differentiation signals for heart and skeletal muscle lineages, plus ubiquitin-dependent protein degradation indicating turnover of transcriptional regulators. This suggests a transcription-regulatory module linked to muscle/heart differentiation.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0006352","count":4},{"id":"GO:0006511","count":3},{"id":"GO:0051123","count":3}]},{"hash":"6206977942479507","title":"ERAD/Ubiquitin-Proteostasis and Aggrephagy","description":"This cluster is dominated by GO terms tied to ubiquitin-dependent ERAD, protein deubiquitination, and autophagy-related processes like aggrephagy, indicating a core role in proteostasis through ubiquitin-mediated degradation and selective autophagy of protein aggregates. The presence of related terms such as regulation of endocytosis and autophagosome maturation supports a broader network of protein quality control and turnover at the ER and cytosol.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":11},{"id":"GO:0016579","count":10},{"id":"GO:0034140","count":10},{"id":"GO:1904378","count":9},{"id":"GO:1901340","count":9}]},{"hash":"2017667597570393710","title":"Mitosis and Protein Quality Control","description":"The cluster centers on cell cycle-related processes: mitotic progression, cell division, and APC-dependent degradation, along with protein folding/isomerization and unfolded protein response, indicating coordination of chromosome segregation with protein quality control during mitosis.","confidence":"High","size":27,"edges":189,"triangles":523,"max_degree":24,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":7},{"id":"GO:0000413","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0051301","count":7},{"id":"GO:2000324","count":7}]},{"hash":"62080440710701941","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":349,"triangles":2876,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":12},{"id":"GO:0019878","count":9},{"id":"GO:0006096","count":8},{"id":"GO:0006103","count":6},{"id":"GO:0033512","count":5}]},{"hash":"985084461361317574","title":"ECM remodeling and angiogenesis","description":"The top GO terms cluster around collagen fibril organization, integrin-mediated adhesion, and endothelial tube morphogenesis, with VEGF signaling regulation pointing to angiogenic activity and extracellular matrix (ECM) remodeling. Additional terms related to keratinocyte differentiation and Notch processing suggest epithelial development context, while TNF and manganese responses hint at broader signaling. Taken together, the suite centers on ECM- and vascular-development processes with epithelial interactions.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":14},{"id":"GO:0030216","count":14},{"id":"GO:0010042","count":14},{"id":"GO:0007220","count":14},{"id":"GO:0034612","count":14}]},{"hash":"480710675872355187","title":"Budding yeast mitosis and cell polarity","description":"Most of the top GO terms are about mitotic division and cytokinesis, mitotic cell cycle, bud neck localization, and maintenance of cell polarity, pointing to a group of proteins coordinating cell division in budding yeast; ribosome biogenesis and embryonic cell shape regulation suggest growth and morphology links, while neuron projection development likely reflects broader cytoskeletal roles.","confidence":"High","size":27,"edges":131,"triangles":233,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0000278","count":7},{"id":"GO:0031175","count":7},{"id":"GO:0042254","count":7},{"id":"GO:0000747","count":6}]},{"hash":"410302049382606105","title":"Developmental fate specification and cell-cycle regulation","description":"These terms point to roles in developmental processes (hair follicle placode formation, glial fate, organ identity maintenance) and in controlling cell proliferation and apoptosis (regulation of cell cycle, positive regulation of apoptotic process). Together they suggest proteins that coordinate development with cell-cycle decisions, rather than a single specialized pathway, hence the label.","confidence":"High","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":26},{"id":"GO:0071681","count":25},{"id":"GO:0048496","count":25},{"id":"GO:0060789","count":25},{"id":"GO:0007403","count":25}]},{"hash":"851980509535117508","title":"Keratinocyte\u2013Endothelial Inflammation Signaling","description":"This cluster centers on keratinocyte biology (migration and differentiation) and endothelial morphogenesis with signaling pathways (integrin and PKC) that drive vascular and tissue remodeling. It also includes immune-related processes (TNF response, monocyte activation) and VEGF production, suggesting coordinated signaling between skin cells, endothelium, and immune cells during inflammation. The peripheral nervous system myelination term is less connected, but overall the terms point to inflammatory signaling and epidermal-vascular crosstalk.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051549","count":9},{"id":"GO:1901509","count":9},{"id":"GO:0022011","count":9},{"id":"GO:0007229","count":9},{"id":"GO:0070528","count":9}]},{"hash":"1857585966748448039","title":"Embryonic organogenesis and neural development","description":"The proteins are tied to diverse embryonic morphogenesis processes across several tissues (heart, pancreas, digestive tract, neural crest/midbrain) and neural development, plus regulatory transcription control, indicating a broad developmental theme rather than a single pathway.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":15},{"id":"GO:0030901","count":14},{"id":"GO:0007626","count":11},{"id":"GO:0031018","count":10},{"id":"GO:0007507","count":10}]},{"hash":"267109278854942915","title":"mRNA maturation, splicing, and translation initiation","description":"The terms cluster around mRNA processing steps\u2014splicing via the spliceosome, splice-site recognition, polyadenylation, export and stabilization\u2014and extend to translation initiation/reinitiation, indicating a cohesive module linking mRNA maturation to translation control.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":16},{"id":"GO:0002188","count":11},{"id":"GO:0001731","count":11},{"id":"GO:0045292","count":11},{"id":"GO:0031047","count":11}]},{"hash":"2056821893918429605","title":"Developmental transcriptional regulators","description":"The cluster's top GO terms cluster around transcriptional control (negative regulation of transcription by RNA polymerase II and DNA-templated transcription) and various developmental processes (left/right patterning, placental/endocrine development, EMT in heart cushion formation, cartilage morphogenesis, pancreatic cell development). This suggests a coherent set of genes governing embryogenesis by regulating gene expression.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":14},{"id":"GO:0006351","count":14},{"id":"GO:0060972","count":13},{"id":"GO:0060806","count":13},{"id":"GO:0035270","count":13}]},{"hash":"1770715281406193391","title":"Immune signaling and phagocytosis regulation","description":"The cluster is strongly enriched for immune-related signaling terms: integrin-mediated signaling, B cell receptor signaling and follicular B cell differentiation, and positive regulation of B cell signaling, suggesting adaptive immune activation. Additional terms like regulation of phagocytosis, Rho/Ras signaling modulation, and IP3 biosynthesis point to cytoskeletal and intracellular signaling control in leukocytes. The lone fungal-origin response term fits with immune recognition. Together these imply a cohesive theme of immune receptor signaling coupled with phagocytic and cytoskeletal regulation.","confidence":"High","size":27,"edges":17,"triangles":5,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071226","count":13},{"id":"GO:0007229","count":11},{"id":"GO:0038028","count":11},{"id":"GO:0050764","count":11},{"id":"GO:0035023","count":11}]},{"hash":"1216792610791684693","title":"Developmental processes and spindle dynamics","description":"The top GO terms cluster around tissue development (spinal cord, skin, heart, prostate-associated developmental regulation) and mitotic/spindle functions (microtubule-based movement, spindle orientation and assembly), suggesting a theme of developmental growth coordinated with cell division machinery. Occasional terms about nutrient response and hypoxia are secondary noise but do not outweigh the central developmental/spindle pattern.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":5},{"id":"GO:0007018","count":4},{"id":"GO:0000132","count":4},{"id":"GO:0007584","count":3},{"id":"GO:0090307","count":3}]},{"hash":"97607367392134881","title":"Neurovascular development","description":"The top GO terms are dominated by nervous system development (neuron development, neural tube closure, telencephalon development) and angiogenesis, suggesting a cluster involved in coordinated neural and vascular formation. Additional terms like insulin receptor signaling, CDK activity regulation, chromatin remodeling and acetylation reflect broader growth regulation and gene expression control common in developmental processes.","confidence":"High","size":27,"edges":7,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001525","count":15},{"id":"GO:0048666","count":11},{"id":"GO:0045736","count":9},{"id":"GO:0008286","count":9},{"id":"GO:0001843","count":9}]},{"hash":"2211990101858575051","title":"Neural development and auditory synapse formation","description":"This cluster shows multiple GO terms tied to neural development and wiring\u2014neuron projection development, axon guidance, synapse assembly, and sensory perception of sound, plus inner ear stereocilium organization\u2014pointing to functions in neural connectivity of the auditory system. While somite specification and transcription regulation reflect broader development programs, the prevailing signal is neural/auditory connectivity.","confidence":"High","size":27,"edges":89,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":3},{"id":"GO:0001757","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0060122","count":3}]},{"hash":"1430987072364774462","title":"Unknown","description":"The top GO terms span skin/epithelial differentiation (keratinocyte differentiation, body hair orientation), Notch signaling, inflammatory and neural development signals, plus unrelated processes like fertilization and chondrocyte differentiation, indicating no single cohesive function for the cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":15},{"id":"GO:0030216","count":13},{"id":"GO:0098869","count":13},{"id":"GO:0010042","count":12},{"id":"GO:0007220","count":12}]},{"hash":"1734244717605917649","title":"Neural development and synaptic adhesion","description":"This cluster is dominated by neural-related terms: cell-cell and cell-matrix adhesion, nervous system development, synapse assembly and GABAergic transmission, plus sensory perception of sound and oligodendrocyte progenitor regulation. Together they point to neural development, synapse formation/maintenance, and myelination processes, with adhesion as a key organizing factor.","confidence":"High","size":27,"edges":69,"triangles":36,"max_degree":21,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0007156","count":24},{"id":"GO:0007399","count":24},{"id":"GO:0007157","count":24},{"id":"GO:0043931","count":23},{"id":"GO:0051965","count":23}]},{"hash":"836211847852759161","title":"RNA Methylation and Small-Molecule Biosynthesis","description":"The cluster centers on RNA guanine-N7 methylation and related RNA modification terms, paired with several biosynthetic processes (polyamines, cobalamin, antibiotics), suggesting a theme around RNA modification within a metabolic/synthetic context; the presence of diverse signaling/stress terms reduces confidence slightly.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006596","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0042391","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0017000","count":2}]},{"hash":"2280341676359333779","title":"Adrenergic-Dopaminergic Neurotransmission and Vascular Regulation","description":"This cluster is dominated by GO terms for adrenergic and dopaminergic signaling, neuronal excitability (regulation of membrane potential), and brain-ward vascular effects (vasoconstriction and blood pressure regulation), with related MAPK signaling pathways. While a few terms touch on immune differentiation, the strongest shared theme is catecholaminergic neurotransmission in the brain and its influence on vascular function. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":25},{"id":"GO:0002035","count":24},{"id":"GO:0001963","count":24},{"id":"GO:1900453","count":24},{"id":"GO:0001994","count":24}]},{"hash":"1647754691205203891","title":"Neural signaling and sensory perception","description":"This cluster is dominated by nervous-system related terms: sensory perception of pain, visual perception, visual learning, dopaminergic synaptic transmission, and cocaine-related behavioral responses, all pointing to neuronal signaling and sensory processing. ERK1/2 cascade regulation supports activity-dependent neural signaling, while prostaglandin response suggests neuromodulation. Peripheral terms like heart development and macrophage chemotaxis are broader, but the core pattern supports neural signaling and sensory processing.","confidence":"Medium","size":27,"edges":213,"triangles":562,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0007507","count":20},{"id":"GO:0070374","count":20},{"id":"GO:0001963","count":19},{"id":"GO:0007601","count":19}]},{"hash":"1226082252926133215","title":"Mammary Gland Morphogenesis Signaling","description":"The top terms include DNA-templated transcription, Wnt signaling, Rho GTPase signaling, integrin signaling, TGF-beta response, and branching involved in mammary gland duct morphogenesis, pointing to a cohesive theme of signaling pathways coordinating transcriptional programs during mammary development and duct morphogenesis. While innate immune and metal-response terms appear, the strongest signal centers on developmental signaling and morphogenesis, making this label both specific and representative.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:0090263","count":6},{"id":"GO:0007266","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0060124","count":6}]},{"hash":"172509019357445682","title":"Innate Immune and Defense Signaling","description":"The top GO terms cluster around innate immune and antimicrobial defense pathways: LPS response, TLR signaling, macrophage activation, defense against Gram-positive bacteria, dsRNA response, and antibacterial peptide biosynthesis. Some terms like collagen fibril organization and meristem regulation are less directly related and may reflect broader stress or ECM remodeling, but the strongest signal is host defense signaling.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030199","count":11},{"id":"GO:0071222","count":10},{"id":"GO:0009934","count":9},{"id":"GO:0090141","count":9},{"id":"GO:0034166","count":9}]},{"hash":"1038253610599720341","title":"Developmental signaling and transcription regulation","description":"Based on the Top Terms, the proteins appear involved in developmental processes across tissues (CNS development, hair follicle morphogenesis, Bergmann glial differentiation) and hormone signaling (estrogen receptor pathway), together with general signaling and transcription initiation machinery (Rho signaling, calcium transport, RNA Pol II initiation and preinitiation complex assembly). The mix points to a broad developmental and transcriptional regulatory role rather than a single specific pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007417","count":3},{"id":"GO:0070588","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0031069","count":2}]},{"hash":"1442419532890212484","title":"Innate Antiviral Interferon Response","description":"The Top Terms include innate immune response, cellular response to type I interferon, cellular response to exogenous dsRNA, and general antiviral defense, pointing to an antiviral innate immunity function. Other terms related to development and hormone signaling appear less central and may reflect broader, non-specific annotations.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":15},{"id":"GO:0071357","count":13},{"id":"GO:0045087","count":13},{"id":"GO:0030850","count":13},{"id":"GO:0071360","count":13}]},{"hash":"1600702548424514591","title":"Organogenesis Signaling and Proliferation","description":"The terms are dominated by positive regulation of signaling pathways (GTPase activity, PI signaling, ERK cascade, Wnt signaling) along with developmental and morphogenesis processes across multiple organs (kidney metanephros, hair follicles, substantia nigra, lung morphogenesis). This points to a cohesive theme of signaling-driven organ development and associated cell proliferation.","confidence":"High","size":27,"edges":5,"triangles":0,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0048015","count":7},{"id":"GO:0070374","count":6},{"id":"GO:0001656","count":6},{"id":"GO:0071338","count":5}]},{"hash":"493508211095593750","title":"Vesicle trafficking and PI signaling","description":"The cluster\u2019s GO terms cluster around intracellular vesicle transport (endosome-lysosome, melanosome, retrograde synaptic vesicle) and phosphatidylinositol-mediated signaling, with additional links to rhabdomere development and angiogenesis. This points to a cohesive theme of membrane trafficking and signaling, with context in neural and vascular development.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008333","count":3},{"id":"GO:0042052","count":2},{"id":"GO:0032402","count":2},{"id":"GO:0048491","count":2},{"id":"GO:0032094","count":2}]},{"hash":"2300274191792930634","title":"Neural development and signaling","description":"The top terms cluster around nervous system development and neural signaling, including brain development, nervous system development, and Roundabout (Robo) axon guidance as well as Hedgehog (Smoothened) signaling and regulation of synaptic vesicle exocytosis, which together point to neural patterning and synaptic communication. While there are a few terms related to other systems (e.g., T cell receptor signaling, kidney development, spermatid development), the dominant theme is neural development and signaling, justifying a neural-focused label.","confidence":"Medium","size":27,"edges":234,"triangles":908,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":8},{"id":"GO:0035385","count":7},{"id":"GO:0050852","count":7},{"id":"GO:0007224","count":7},{"id":"GO:0007399","count":7}]},{"hash":"255163517538200230","title":"Rho GTPase\u2013driven cell migration and lamellipodium assembly","description":"The cluster is dominated by GO terms tied to actin cytoskeleton dynamics and motility (cell migration, lamellipodium assembly, Rho and small GTPase signaling, endocytosis linked to actin remodeling). This suggests proteins here function together in actin-based movement and cytoskeletal regulation, despite a few unrelated terms present.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0030032","count":4},{"id":"GO:0006348","count":4},{"id":"GO:0006897","count":4}]},{"hash":"2100912327327273390","title":"Immune Signaling and Phagocytosis","description":"The cluster centers on immune signaling and phagocytic activity: innate immune response, B cell receptor signaling, T cell costimulation, phagocytosis, and regulation of TNF/IL-6 production, with NK cell regulation and a note on mitochondrial activity linked to activated immune cells.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0006911","count":2},{"id":"GO:0031295","count":2}]},{"hash":"844019447068578632","title":"DNA Damage Response and Cell Cycle Regulation","description":"The top GO terms point to genome maintenance: base-excision repair, DNA recombination, apoptotic processes, and regulation of G1/S transition, all hallmarks of DNA damage response and checkpoint control. A xenobiotic/stress response term supports a general stress signaling context. Some older/obsolete terms and a few unrelated terms (renal water transport, glycogen regulation, hemolysis) likely reflect annotation noise rather than a shared function. Overall, the dominant theme is DNA damage response coupled with cell cycle regulation.","confidence":"Medium","size":27,"edges":37,"triangles":17,"max_degree":8,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006284","count":11},{"id":"GO:0007568","count":10},{"id":"GO:0006310","count":8},{"id":"GO:0042493","count":8},{"id":"GO:0006915","count":7}]},{"hash":"2123559059708789494","title":"Brain GPCR signaling in thermoregulation and pain","description":"The cluster centers on neuronal GPCR signaling pathways, with strong representation of adenylate cyclase activation, G protein-coupled receptor signaling, and ERK cascade, alongside terms related to temperature response, diet-induced thermogenesis, and pain perception. It also includes brain-specific aspects like the brain renin-angiotensin system and blood pressure regulation, plus energy metabolism as indicated by the electron transport chain term. Together, these terms suggest a coherent theme of GPCR-driven signaling in the brain that modulates thermoregulation, pain perception, and cardiovascular/metabolic regulation.","confidence":"High","size":27,"edges":8,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0002024","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0007190","count":15}]},{"hash":"1276057301632290360","title":"Antiviral Immune Response and Cytokine Regulation","description":"The proteins are enriched for adaptive, humoral, and innate immune responses, with strong signals for antiviral defense (dsRNA sensing and response), and regulation of cytokines (IL-5 and IL-13) and STAT signaling. The dexamethasone response also points to glucocorticoid modulation of immune signaling. Together, they suggest a coherent antiviral immune signaling and cytokine-regulation theme.","confidence":"High","size":27,"edges":341,"triangles":2686,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":13},{"id":"GO:0006959","count":12},{"id":"GO:2000663","count":12},{"id":"GO:0045087","count":12},{"id":"GO:0033141","count":12}]},{"hash":"1741525705241300601","title":"Developmental vascular remodeling and morphogenesis","description":"This cluster shows terms tied to tissue and vessel development and remodeling (negative regulation of blood vessel remodeling, regulation of vascular permeability) plus broader morphogenesis processes (imaginal leg morphogenesis, endocardial cushion EMT, neuron migration). The common theme is developmental remodeling of tissues, especially vascular and structural morphogenesis, rather than a single canonical pathway. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060313","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0060268","count":3},{"id":"GO:0002692","count":3}]},{"hash":"357827578414219348","title":"Unknown","description":"The top GO terms span several unrelated processes (antibiotic biosynthesis and response, various biosynthetic pathways like biotin and poly-hydroxybutyrate, mitochondrial electron transport, ribosome assembly and translation, and transcription regulation). There is no clear, cohesive function linking these terms, and the cluster has no edges or interactions, so a single descriptive label is not justifiable.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0017000","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0042619","count":2},{"id":"GO:0006355","count":2}]},{"hash":"2158559079802844604","title":"Membrane transporter proteins (xenobiotic/nutrient)","description":"Top GO terms point to transmembrane transport activities across membranes for xenobiotics, vitamins, sugars and ions, plus vesicular neurotransmitter loading. This pattern is characteristic of transporter proteins that move substrates across membranes, rather than enzymes, suggesting the cluster represents membrane transporters involved in xenobiotic and nutrient transport plus related vesicular processes.","confidence":"High","size":27,"edges":15,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":24},{"id":"GO:0035461","count":24},{"id":"GO:0042891","count":17},{"id":"GO:0071805","count":16},{"id":"GO:0042908","count":15}]},{"hash":"640758121196580580","title":"Ribosome biogenesis and translation","description":"The cluster is clearly centered on ribosome production and protein synthesis, with multiple terms for ribosome biogenesis, cytoplasmic translation, ribosomal subunit biogenesis and export, and tRNA modification. These together point to a cohesive group of proteins involved in ribosome assembly and function. Some signaling terms (ERK cascade) and cell-cycle term appear as ancillary associations, but do not override the core ribosome/translation theme.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":6},{"id":"GO:0002181","count":5},{"id":"GO:1903833","count":4},{"id":"GO:0070371","count":4},{"id":"GO:0007049","count":3}]},{"hash":"1799998958104897241","title":"Clathrin-mediated endocytosis and GPCR trafficking","description":"This cluster is dominated by GO terms for receptor internalization via clathrin pathways and GPCR endocytosis, along with activation of small GTPases and actin remodeling processes like lamellipodium assembly, suggesting a core function in receptor trafficking and related signaling. While other terms (fatty acid metabolism, morphogenesis) appear, they are less central to the principal theme. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0072583","count":9},{"id":"GO:0002031","count":9},{"id":"GO:0032000","count":7},{"id":"GO:0008286","count":7},{"id":"GO:0007264","count":7}]},{"hash":"1961368764216744857","title":"Ubiquitin-Dependent Proteolysis and ERAD","description":"The cluster is dominated by ubiquitin-dependent proteolysis signals (ubiquitin-dependent protein catabolic process) with ERAD involvement and protein polyubiquitination, pointing to a group of proteins centered on ubiquitin-mediated degradation. Additional terms suggest neuronal/synaptic and immune signaling contexts, but the strongest theme is proteostasis via ubiquitination and ERAD.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0030433","count":9},{"id":"GO:0060386","count":9},{"id":"GO:0042752","count":8},{"id":"GO:0045087","count":7}]},{"hash":"1038372281691557624","title":"Macromolecule processing and trafficking","description":"The top GO terms cluster around protein processing and assembly (protein processing, protein homooligomerization, mitochondrial respiratory chain complex III assembly) and intracellular handling and export (inter-Golgi vesicle-mediated transport, mRNA export from nucleus). There are also broader replication-related terms present, which suggests the proteins participate in general cellular biosynthesis and maintenance rather than a single focused pathway. This makes the label \u201cmacromolecule processing and trafficking\u201d a concise, representative description, albeit with some heterogeneity in function. ","confidence":"Medium","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0019079","count":3},{"id":"GO:2000984","count":2},{"id":"GO:0048219","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0016485","count":2}]},{"hash":"956779551714794628","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":3},{"id":"GO:1903259","count":2},{"id":"GO:1900153","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0006620","count":1}]},{"hash":"751831179772317892","title":"Diverse Substrate Membrane Transporters","description":"These proteins are strongly associated with transmembrane transport across a wide range of substrates\u2014xenobiotics, vitamins, sugars (arabinose, galactose), nitrate/nitrite, and potassium ions\u2014with an additional term for neurotransmitter loading into vesicles. This points to a cluster of membrane transporter proteins with broad substrate specificity, rather than enzymes or receptors. ","confidence":"High","size":27,"edges":46,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":26},{"id":"GO:0035461","count":26},{"id":"GO:0042891","count":20},{"id":"GO:0071805","count":19},{"id":"GO:0042908","count":18}]},{"hash":"835066224284986260","title":"Oxidative Detoxification and Immune Signaling","description":"The terms show strong enrichment for detoxification of cellular oxidants and glutathione metabolism, toxin catabolism, and responses to toxic substances, pointing to oxidative stress management. Additional terms related to prostaglandin biosynthesis and immune/hematopoietic processes (growth regulation, myeloid progenitor proliferation, neutrophil regulation) suggest coordinated metabolic and inflammatory signaling. Together, these indicate a cluster focused on oxidative detoxification coupled with immune and metabolic/regulatory signaling.","confidence":"High","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":27},{"id":"GO:0040008","count":26},{"id":"GO:0006749","count":26},{"id":"GO:0042594","count":26},{"id":"GO:0009407","count":26}]},{"hash":"195167906868497575","title":"Mitotic Cell Cycle and DNA Replication","description":"The cluster is dominated by mitotic cell cycle and DNA replication terms (GO:0000278 and GO:0006260 with 27 occurrences each), pointing to proteins involved in cell division and genome duplication. While there are other terms related to development and immune responses, the strongest, most representative signal is cell-cycle progression and DNA synthesis. Occasional other annotations may reflect broader roles or cross-species annotations, but they do not override the core theme.","confidence":"High","size":27,"edges":7,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":27},{"id":"GO:0006260","count":27},{"id":"GO:0033129","count":26},{"id":"GO:0090606","count":26},{"id":"GO:0061308","count":26}]},{"hash":"1950919689046417123","title":"Chromatin Regulation and Histone Modification","description":"These terms cluster around chromatin state control: heterochromatin formation/maintenance, heterochromatin boundary formation, and histone acetylation. The presence of rDNA heterochromatin formation and pericentric heterochromatin maintenance points to heterochromatin regulation, while histone acetylation terms (even if obsolete) and chromatin remodeling steps indicate epigenetic modification. A supplementary signal is regulation of cell cycle and a cellular response to estradiol, which can involve chromatin remodeling. Overall, the proteins likely function in chromatin regulation and epigenetic control.","confidence":"Medium","size":27,"edges":151,"triangles":424,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0071392","count":11},{"id":"GO:0000183","count":10},{"id":"GO:0051726","count":10},{"id":"GO:0018003","count":10},{"id":"GO:0032703","count":9}]},{"hash":"2275909820028714646","title":"Neuroendocrine Thermogenesis and Blood Pressure Signaling","description":"The cluster combines thermogenesis and temperature-response terms with energy metabolism (electron transport chain) and neuroendocrine GPCR-cAMP signaling that regulate blood pressure via brain renin\u2013angiotensin system, membrane potential, and xenobiotic response, suggesting coordinated thermogenic energy regulation and cardiovascular signaling in a neuroendocrine context.","confidence":"High","size":27,"edges":17,"triangles":1,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0022900","count":16},{"id":"GO:0010579","count":16}]},{"hash":"1384164422005073140","title":"GPCR signaling and thermogenesis","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, activation of adenylate cyclase, and thermogenesis/temperature response, plus related processes like membrane potential regulation and autonomic outputs (saliva secretion, blood pressure regulation). This points to a set of proteins involved in GPCR-mediated signaling that links energy metabolism and thermogenic responses, with possible neuroendocrine control of cardiovascular and salivary functions. ","confidence":"High","size":27,"edges":7,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":21},{"id":"GO:0022900","count":21},{"id":"GO:0002024","count":21},{"id":"GO:0071502","count":21},{"id":"GO:0019233","count":21}]},{"hash":"1906563545355520536","title":"Amino acid salvage and phospholipid biosynthesis","description":"Based on the top GO terms, there are multiple occurrences of L-methionine salvage (from SAM and from MTA) and L-threonine biosynthesis, as well as choline/ethanolamine metabolism and phosphatidylethanolamine biosynthesis. This pattern indicates a cluster enriched for amino acid metabolism and phospholipid biosynthesis, with some auxiliary terms (RNA silencing and stress responses) likely reflecting broader cellular context rather than a shared specific function. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019284","count":5},{"id":"GO:0009088","count":5},{"id":"GO:0019509","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0016310","count":5}]},{"hash":"865069384828155338","title":"Neural development and gene expression regulation","description":"Top GO terms indicate a focus on neural differentiation (neuron projection development; neuron apoptotic process; glial apoptotic process) alongside transcription/splicing control (mRNA splicing via spliceosome; DNA-templated transcription; imprinting regulation) and cell cycle modulation. This suggests a cluster of proteins involved in neural development with broad regulation of gene expression and apoptosis, rather than a single pathway. Medium","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0001501","count":2},{"id":"GO:0034349","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0051402","count":2}]},{"hash":"1699088762359042833","title":"Rho-dependent cytoskeleton remodeling and vesicle trafficking","description":"This cluster is enriched for GO terms involving Rho-mediated signal transduction, actin cytoskeleton organization, exocytosis, and Golgi localization, pointing to a coordinated role in reorganizing the cytoskeleton and directing vesicle trafficking to the cell surface and Golgi, with links to junction assembly and signaling cascades such as JNK.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0030036","count":5},{"id":"GO:0051683","count":5},{"id":"GO:0006887","count":5},{"id":"GO:0007266","count":5}]},{"hash":"1955251594271010865","title":"Cytoskeletal remodeling and cell-matrix adhesion","description":"The terms emphasize actin-based protrusions (filopodium, ruffle), adhesion complexes (focal adhesion, integrin activation), and Rho signaling, with endomembrane system organization hinting at trafficking for adhesion machinery. Glycosylation-related processes likely support membrane/adhesion proteins, pointing to a coordinated theme of cytoskeletal dynamics with cell\u2013matrix interactions.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010256","count":3},{"id":"GO:0032288","count":3},{"id":"GO:0048041","count":3},{"id":"GO:0006011","count":2},{"id":"GO:0052573","count":2}]},{"hash":"286378659295007121","title":"Vascular inflammation and vasomotor signaling","description":"These proteins cluster around inflammatory and vascular regulatory processes: inflammatory response, response to lipopolysaccharide, blood coagulation, and pain; along with vasomotor control terms like blood pressure regulation, vasoconstriction, and smooth muscle contraction. GPCR- and Rho-signaling terms further tie to signaling cascades that modulate vascular tone. The electron transport chain term appears but the shared theme centers on inflammation coupled with vascular signaling and constriction, making \"Vascular inflammation and vasomotor signaling\" a concise, representative label.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":26},{"id":"GO:0035025","count":26},{"id":"GO:0010579","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0045986","count":26}]},{"hash":"1442697876131013350","title":"Phosphoinositide signaling and membrane localization","description":"These proteins predominantly show GO terms tied to phosphatidylinositol phosphate metabolism (biosynthetic and dephosphorylation steps) and targeted localization to membranes (plasma membrane, stress granule). While other terms touch diverse processes (TGF-beta signaling, JNK regulation, myelination, ion transport), the strongest common theme is phosphoinositide-mediated signaling and membrane association, implying roles in membrane signaling/trafficking rather than a single linear pathway. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":3},{"id":"GO:0046329","count":3},{"id":"GO:0046854","count":2},{"id":"GO:0090002","count":2},{"id":"GO:0042552","count":2}]},{"hash":"510541836072696534","title":"Immune cell apoptosis and TNF signaling","description":"Top GO terms indicate a strong focus on regulation of apoptotic pathways (extrinsic and intrinsic), TNF production, and B cell\u2013specific processes, suggesting a cluster of proteins involved in apoptotic signaling within the immune system (including lymphocytes and endothelial contexts). The coherence around immune-related apoptosis supports a concise label that differentiates this cluster from general stress responses.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":4},{"id":"GO:0097202","count":3},{"id":"GO:0070230","count":3},{"id":"GO:0002377","count":3},{"id":"GO:0001783","count":3}]},{"hash":"1852968587433346136","title":"EGF-ERK signaling and cytoskeletal remodeling in development","description":"The cluster centers on the ERK1/2 cascade and cellular response to epidermal growth factor, with supporting terms for actin filament severing, vesicle-mediated transport, and ECM secretion, plus development-related terms for kidney and retina. This pattern points to a module where signal transduction via EGF/ERK modulates the cytoskeleton, trafficking, and extracellular interactions in developmental contexts.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070371","count":3},{"id":"GO:0051014","count":2},{"id":"GO:1902896","count":2},{"id":"GO:0071364","count":2},{"id":"GO:0035584","count":2}]},{"hash":"1551005074685376651","title":"DNA replication and cell cycle machinery","description":"The top GO terms cluster around DNA-templated transcription, DNA replication, and cell division, with SOS response supporting a DNA maintenance theme. While other terms (insulin response, vitamin and fatty acid biosynthesis) appear, they likely reflect broader metabolic roles or annotation noise. Overall, the dominant signal points to genome replication/expression and proliferation functions, justifying a DNA-replication/cell-cycle label.","confidence":"Medium","size":26,"edges":300,"triangles":2079,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0051260","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0032869","count":7},{"id":"GO:0009236","count":6}]},{"hash":"439528567146620296","title":"Transmembrane metabolite transport and mitochondrial dynamics","description":"The cluster is dominated by GO terms for transmembrane transport of various metabolites (NAD, ornithine, glycine, thiamine pyrophosphate, deoxynucleotides) and mitochondrial processes (membrane fission and permeability regulation). Together, these point to a coherent theme of moving metabolites across membranes and maintaining mitochondrial function, with amino acid starvation responses supporting metabolic adaptation; the liver regeneration term may reflect tissue metabolic context but is less central to the core theme.","confidence":"High","size":26,"edges":41,"triangles":4,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035352","count":14},{"id":"GO:0034198","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0097421","count":14},{"id":"GO:0036233","count":14}]},{"hash":"1710993190603146181","title":"Unknown","description":"The listed GO terms span several distinct themes\u2014mitosis and cell cycle, ER-to-Golgi vesicle trafficking, ERAD-related quality control, and TORC1 signaling\u2014plus less related terms like brain development and defense against Gram-positive bacteria. With no observed edges or coherent functional cluster connecting these terms, there isn\u2019t a single unifying function to label the cluster. Therefore this cluster is best named Unknown with no confidence in a representative function.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0051301","count":11},{"id":"GO:0006888","count":11},{"id":"GO:0051260","count":10},{"id":"GO:0007420","count":10}]},{"hash":"2036450970705451064","title":"Broad stress-response signaling","description":"The top GO terms collectively point to a mix of stress-related responses (heat, pain, muscle stretch) and signaling pathways (GPCR, NOD2) along with regulatory processes (IL-12 production, telomere maintenance, mRNA processing, cell growth). This suggests proteins in the cluster participate broadly in cellular signaling and stress response rather than a single, cohesive function. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":8},{"id":"GO:0007205","count":8},{"id":"GO:0009408","count":8},{"id":"GO:0006397","count":7},{"id":"GO:0097497","count":6}]},{"hash":"112229752201892343","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":13},{"id":"GO:0071456","count":13},{"id":"GO:0000278","count":12},{"id":"GO:0051028","count":12},{"id":"GO:2000601","count":12}]},{"hash":"2270236823691915662","title":"Innate Immunity and Synaptic Remodeling","description":"This cluster is dominated by innate immune terms (defense response to Gram-positive bacteria; innate immune response) but also shows clear neuronal/synaptic organization signals (protein localization to synapse; dendritic spine morphogenesis; receptor clustering), with cytoskeletal remodeling (Rho signaling) and developmental processes (angiogenesis, labyrinthine vascular development) that can tie immune and neural functions together. This suggests a theme of innate immune activity linked with synaptic remodeling and development.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0050830","count":23},{"id":"GO:0035418","count":21},{"id":"GO:0008285","count":21},{"id":"GO:0045766","count":21},{"id":"GO:0002062","count":21}]},{"hash":"284667840373545329","title":"Growth signaling and developmental regulation with stress responses","description":"The top GO terms point to regulatory signaling (positive regulation of GTPase activity; TORC1 signaling), cell cycle processes (mitotic cell cycle, chromatid cohesion), development (neural tube closure, multicellular organism development), and various stress/defense responses (cadmium ion response, defense against Gram-positive bacteria), with additional regulation via mRNA transport and serine dephosphorylation. This suggests a broad theme of growth and developmental regulation intertwined with stress responses, rather than a single, tightly defined pathway. The absence of edges in the cluster also indicates functional diversity or incomplete connectivity. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0050830","count":6},{"id":"GO:0051754","count":6},{"id":"GO:0000278","count":5},{"id":"GO:0038202","count":5}]},{"hash":"1527601296148193947","title":"ECM Remodeling and Angiogenesis","description":"This cluster is dominated by GO terms tied to extracellular matrix disassembly, collagen catabolic processes, vasculature development, and positive regulation of angiogenesis, all pointing to tissue remodeling and new blood vessel formation. Amelogenesis and multicellular growth further support a theme of developmental matrix dynamics. A few terms (defense response to Gram-positive bacterium, RNA guanine-N7 methylation, mechanical stimulus response) are less directly connected and may reflect broader annotation or multifunctionality, but do not override the central theme. Overall, the cluster likely represents proteins involved in extracellular matrix remodeling and angiogenic processes, with supporting roles in tooth enamel formation and growth.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0036265","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0001944","count":2}]},{"hash":"1007983222568002399","title":"Nuclear Transport and Mitosis Machinery","description":"Top GO terms indicate a focus on nuclear import mechanisms (NLS-bearing and ribosomal protein import into nucleus), nuclear pore complex assembly, and mitotic nuclear membrane reassembly, with related cell-cycle processes like chromatid cohesion. While a couple of terms are less directly related (vacuole inheritance, organ identity maintenance), the strongest signal is nuclear transport and mitotic envelope dynamics.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0006607","count":9},{"id":"GO:0048496","count":7},{"id":"GO:0000011","count":7},{"id":"GO:0006610","count":7}]},{"hash":"1960749942518938262","title":"Neural development and differentiation","description":"The top GO terms point to brain-related processes, notably substantia nigra development and memory, suggesting a neural development/differentiation theme. Additional terms like epithelial-to-mesenchymal transition and regulation of cell shape reflect developmental transitions that can occur in neural lineages. Some terms about transcriptional regulation and protein complex formation are general but compatible with neural differentiation programs, while methylmercury response and complement activation can relate to neural stress and brain immune interactions. Overall, the cluster seems best described as neural development with related differentiation and neuroimmune signals.","confidence":"Medium","size":26,"edges":54,"triangles":26,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0051290","count":10},{"id":"GO:0007613","count":9},{"id":"GO:0021762","count":8},{"id":"GO:0006919","count":8}]},{"hash":"2240848334863415197","title":"Nervous System Development and Axon Guidance","description":"This cluster\u2019s prominent GO terms center on nervous system development and axon guidance (axon extension, trigeminal nerve structure, paranodal junction assembly, semaphorin-plexin signaling), pointing to a neural pathfinding/structural role. A few terms reference metabolic or stress responses, but they are secondary to the neural development theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070542","count":6},{"id":"GO:0048846","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0034198","count":5},{"id":"GO:0043065","count":5}]},{"hash":"68040076084072419","title":"Tissue development and differentiation","description":"Several top GO terms cluster around development across multiple tissues\u2014fat cell differentiation, heart development, chondroblast differentiation, and various morphogenesis terms\u2014along with DNA-templated transcription and nuclear receptor signaling. This suggests a shared theme of coordinated development and differentiation, supported by transcriptional regulation and signaling pathways rather than a single specific function. ","confidence":"Medium","size":26,"edges":67,"triangles":50,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045444","count":19},{"id":"GO:0007507","count":17},{"id":"GO:0006351","count":17},{"id":"GO:0038185","count":15},{"id":"GO:0060591","count":15}]},{"hash":"698136467318954902","title":"Embryonic organ development","description":"Top GO terms reflect embryonic development across multiple organ systems (nervous system patterning: metencephalon and telencephalon; spinal cord neuron differentiation; heart and pancreas development; digit morphogenesis; kidney ureteric bud formation). This points to a shared role in broad embryonic organogenesis rather than a single, specific function.","confidence":"High","size":26,"edges":52,"triangles":31,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":26},{"id":"GO:1902870","count":26},{"id":"GO:0042663","count":26},{"id":"GO:0002087","count":26},{"id":"GO:0021978","count":26}]},{"hash":"1164614718567785397","title":"Developmental signaling and cell adhesion","description":"This cluster includes development-related terms (lens morphogenesis, heart development, spermatid development) alongside signaling and adhesion terms (actin cytoskeleton regulation by cell\u2013cell adhesion, Rho signaling, B cell receptor signaling, innate immune response, NK cell regulation). The common thread appears to be signaling and adhesion processes operating across development and immune contexts, rather than a single canonical pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0002089","count":14},{"id":"GO:0010765","count":14},{"id":"GO:0007286","count":11},{"id":"GO:0050853","count":11},{"id":"GO:0002859","count":10}]},{"hash":"680534148869871392","title":"Retina Development and Visual Signaling","description":"The cluster is dominated by GO terms related to retina and visual processes: retina development in camera-type eye, regulation of opsin-mediated signaling pathway, visual perception, and dopaminergic synaptic transmission. It also includes the adenylate cyclase-activating GPCR signaling pathway and electron transport chain, which align with photoreceptor signaling and energy metabolism. Some terms like heart development and eating behavior reflect broader dopamine-related roles but do not override the retina-centric theme. Therefore, the proteins likely constitute a retina/visual system module.","confidence":"High","size":26,"edges":33,"triangles":1,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":19},{"id":"GO:0022900","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0001963","count":18}]},{"hash":"1209609991083402177","title":"Neuronal synaptic vesicle trafficking and mitochondrial dynamics","description":"The top GO terms cluster around synaptic function and neuronal development (regulation of synaptic vesicle exocytosis, regulation of synaptic vesicle endocytosis, excitatory postsynaptic potential, substantia nigra development), complemented by mitochondrial dynamics (mitochondrial membrane fission, mitochondrial maintenance). While a few terms are immune or xenobiotic-related, the dominant signal is neuronal synaptic activity supported by mitochondrial dynamics, justifying this label.","confidence":"Medium","size":26,"edges":24,"triangles":2,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042832","count":8},{"id":"GO:2000300","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0035690","count":7}]},{"hash":"1769085811366347040","title":"Post-transcriptional RNA processing and translation regulation","description":"This cluster is enriched for GO terms covering splicing (via spliceosome), mRNA export, stabilization, poly(A) tail regulation, and ncRNA/miRNA-mediated gene silencing, as well as formation of translation preinitiation complexes. The common theme is coordinated control of gene expression after transcription, through RNA processing, transport, stability, and initiation of translation.","confidence":"High","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":23},{"id":"GO:0048026","count":17},{"id":"GO:0031047","count":17},{"id":"GO:0006376","count":15},{"id":"GO:0006406","count":15}]},{"hash":"2017235873906021922","title":"Mitotic Regulation and Heart Valve Morphogenesis","description":"This cluster is enriched for mitosis/cell cycle processes (mitotic cell cycle, APC/C-dependent catabolic process, cell division, DNA damage response) and ubiquitination (K11-linked), suggesting a core role in mitotic control. The presence of heart development terms (endocardial cushion morphogenesis, atrioventricular valve morphogenesis) points to a subset of these proteins functioning during heart valve morphogenesis, indicating the cluster may reflect regulation of cell division in cardiac development alongside broader developmental processes.","confidence":"High","size":26,"edges":28,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0006977","count":3},{"id":"GO:0003203","count":3},{"id":"GO:0003181","count":3},{"id":"GO:0000381","count":3}]},{"hash":"234784592888234693","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000472","count":4}]},{"hash":"212330006194985963","title":"Neural development and signaling","description":"This cluster is dominated by GO terms related to nervous system development, learning, and dopamine-responsive signaling, including Roundabout and Smoothened pathways, ERK activation, and calcium-dependent exocytosis, which together point to neuronal differentiation, signaling, and synaptic activity. Golgi-to-plasma membrane transport and nuclear envelope organization support neuronal vesicle trafficking and nuclear dynamics, reinforcing a neural development/synaptic function theme.","confidence":"High","size":26,"edges":170,"triangles":297,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":8},{"id":"GO:0035385","count":7},{"id":"GO:0043001","count":6},{"id":"GO:0001822","count":6},{"id":"GO:0007224","count":6}]},{"hash":"1404958253937255610","title":"Unknown","description":"These GO terms cover adipocyte differentiation, pain perception, innate immune signaling (NOD2, IL-12 regulation), telomere maintenance, endothelial remodeling, and even cardiac electrophysiology. There is no single unifying theme across the cluster; the terms reflect multiple unrelated processes rather than a coherent functional module.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":10},{"id":"GO:0007205","count":10},{"id":"GO:0010745","count":10},{"id":"GO:0098907","count":10},{"id":"GO:0048265","count":10}]},{"hash":"412543392550664155","title":"Angiogenesis and inflammatory response cluster","description":"Based on top GO terms, this cluster centers on positive regulation of angiogenesis and acute-phase inflammatory response, with additional terms related to hypoxia, xenobiotic response, and remodeling of cell adhesion and protease activity. The inclusion of eye and gonad development terms suggests broader developmental roles, but the dominant themes point to vascular remodeling and inflammation, consistent across tissues.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0006953","count":5},{"id":"GO:2001027","count":4},{"id":"GO:0033629","count":4},{"id":"GO:0010951","count":4}]},{"hash":"2172348328758941942","title":"Diverse transmembrane solute transporters","description":"These proteins cluster around a broad set of GO terms for transporting various solutes across membranes, including xenobiotics, vitamins, ions, and neurotransmitter-related vesicle loading. The common theme is membrane transporter activity with diverse substrates, rather than a single substrate-specific function.","confidence":"High","size":26,"edges":288,"triangles":1817,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":26},{"id":"GO:0035461","count":26},{"id":"GO:0071805","count":24},{"id":"GO:0042908","count":24},{"id":"GO:0098700","count":19}]},{"hash":"1762058120548243819","title":"Embryogenesis and organ morphogenesis","description":"The GO terms cluster around developmental processes across multiple tissues: left/right pattern formation; placenta development; endocrine system development; trophoblast differentiation; pancreatic cell development; epithelial-mesenchymal transition in cardiac cushion; cartilage morphogenesis; mesoderm development; hair follicle morphogenesis; palate/roof of mouth development. This indicates a general theme of embryonic patterning and tissue morphogenesis rather than a single tissue, so the label fits.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":21},{"id":"GO:0060806","count":21},{"id":"GO:0035270","count":21},{"id":"GO:0060707","count":21},{"id":"GO:0003323","count":21}]},{"hash":"1101566707500874626","title":"Embryonic Development and Organogenesis","description":"This cluster centers on developmental processes across multiple tissues: in utero embryonic development and various organ morphogenesis events (pancreas, fat, semicircular canal) plus nervous system maturation (neuron maturation, habenula development) and transcriptional regulation, suggesting a cohesive theme of embryonic patterning and tissue differentiation. The lipopolysaccharide response is a secondary signal, but the dominant pattern is developmental organization and organogenesis.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0042551","count":6},{"id":"GO:0001701","count":6},{"id":"GO:0032496","count":5},{"id":"GO:0021986","count":5}]},{"hash":"498950523300870307","title":"Adaptive immune signaling and lymphoid development","description":"The top GO terms cluster around innate/adaptive immune responses, immunological synapse formation, B cell receptor signaling, and thymus development, suggesting proteins involved in immune activation and lymphoid organ maturation. Although a few developmental terms appear, the dominant theme is immune signaling in adaptive immunity.","confidence":"Medium","size":26,"edges":26,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0001771","count":5},{"id":"GO:0006958","count":5},{"id":"GO:1900042","count":4},{"id":"GO:0050853","count":4}]},{"hash":"1234333167056538873","title":"B cell activation and antibody production","description":"The top GO terms are dominated by adaptive immune functions: immunoglobulin production, positive regulation of B cell activation, and interleukin-2 production, complemented by cell\u2013cell adhesion and actin cytoskeleton regulation that underpin immune synapse formation. While NK/T cell regulation terms appear, the overall theme centers on B cell\u2013driven humoral immunity and immune cell interactions.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007156","count":11},{"id":"GO:0007157","count":11},{"id":"GO:0002859","count":10},{"id":"GO:0043318","count":10},{"id":"GO:0090138","count":10}]},{"hash":"181912645502903449","title":"Multilineage development and differentiation","description":"The top GO terms point to differentiation and developmental programs across several tissues (muscle, glial/neuronal lineages, inner ear, nephron), with transcription by RNA polymerase II as a core activity, suggesting these proteins act in broad developmental regulation. Some terms about immune or drug response appear as less central context, but the dominant theme is lineage specification and transcriptional control across multiple tissues.","confidence":"Medium","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":24},{"id":"GO:2001038","count":23},{"id":"GO:0048712","count":23},{"id":"GO:0007518","count":22},{"id":"GO:0006959","count":22}]},{"hash":"1426290528669489759","title":"Lipid and Steroid Biosynthesis","description":"The top GO terms point to biosynthesis of lipids and steroid-related metabolites (fatty acid elongation, sphingolipid biosynthesis, retinol metabolism, C21-steroid hormone metabolism, testosterone and glucocorticoid biosynthesis) as well as related polymer biosynthesis (poly-hydroxybutyrate) and antibiotic biosynthetic processes, suggesting a cohesive theme of production/metabolism of hydrophobic small molecules and steroids. Confidence: Medium","confidence":"","size":26,"edges":241,"triangles":1173,"max_degree":24,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":24},{"id":"GO:0055114","count":24},{"id":"GO:0017000","count":23},{"id":"GO:0006704","count":23},{"id":"GO:0008207","count":23}]},{"hash":"1068810435632381691","title":"Developmental angiogenesis and neural signaling","description":"Top GO terms point to vascular development (angiogenesis), EMT, and kidney development, together with neural signaling events (long-term synaptic potentiation, neurotransmitter secretion) and signaling inputs (calcium response, GPCR signaling, NF-kappaB regulation). The mix suggests proteins involved in broad developmental processes coordinating vascular, renal, and neural signaling, rather than a single cohesive pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0071277","count":3},{"id":"GO:0001837","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0043388","count":2}]},{"hash":"1226309094546399261","title":"Epithelial polarity and junction assembly","description":"The top GO terms cluster around apical/basal polarity establishment, adherens junction localization and assembly, and polarized epithelial differentiation, with related organ morphogenesis (lung/renal) processes, indicating proteins jointly support epithelial polarity and junction formation during development.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":12},{"id":"GO:0045197","count":12},{"id":"GO:0072205","count":12},{"id":"GO:0030901","count":12},{"id":"GO:0071896","count":12}]},{"hash":"403111821385103889","title":"Vascular development signaling","description":"The top GO terms cluster around angiogenesis and vascular development, including regulation of angiogenesis, angiogenesis itself, kidney development (vasculature-related), and signaling pathways (ERK, Rho) and mechanical stimulus response, all characteristic of endothelial cell remodeling; some immune terms appear but are less central to the core vascular theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045765","count":3},{"id":"GO:0045404","count":3},{"id":"GO:0045590","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0035023","count":3}]},{"hash":"203393515721195750","title":"Embryonic organ morphogenesis and developmental transcription","description":"The top GO terms emphasize DNA-templated transcription alongside a wide range of organ morphogenesis processes (hindlimb, eye, outflow tract, prostate, gonad, habenula) and hormonal signaling (estrogen receptor pathway). This points to a cohesive theme where transcriptional regulation drives embryonic organ development and morphogenesis, sometimes modulated by hormone signaling. ","confidence":"High","size":26,"edges":34,"triangles":5,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":14},{"id":"GO:0060527","count":13},{"id":"GO:2000288","count":13},{"id":"GO:0035116","count":13},{"id":"GO:0048048","count":13}]},{"hash":"987020592645693139","title":"Ribosome biogenesis and translation machinery","description":"Based on the enrichment of translation-related GO terms, including translation (GO:0006412), ribosome biogenesis (GO:0042254), tRNA modification (GO:0006400), and translational initiation/elongation (GO:0006413, GO:0051301, GO:0055114), the cluster appears to group proteins involved in the protein synthesis apparatus and ribosome assembly. Additional terms for cell cycle and transcription regulation are present but secondary to the core translation-centric theme.","confidence":"High","size":26,"edges":4,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0046677","count":4},{"id":"GO:0006400","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0007049","count":4}]},{"hash":"1128839998223056070","title":"NF-kappaB-driven T cell activation and dendritic cell differentiation","description":"The top GO terms cluster around immune signaling and antigen-presenting cell dynamics, notably canonical NF-kappaB signaling, T cell costimulation, monocyte chemotaxis, and positive regulation of dendritic cell differentiation. This pattern points to an immune activation program where T cells engage with dendritic cells and monocytes, with NF-kappaB as a central mediator. A few terms (e.g., positive regulation of viral entry into host cell) are less directly aligned but do not overturn the core theme of NF-kappaB\u2013driven immune activation.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0002548","count":3},{"id":"GO:2001200","count":3},{"id":"GO:0046598","count":3}]},{"hash":"680393798959046020","title":"Neural signaling and plasticity via ERK pathways","description":"This cluster is dominated by neural-related processes: dopaminergic synaptic transmission, visual perception and learning, pain perception, and cocaine response, with protein phosphorylation and positive regulation of the ERK1/2 cascade highlighting ERK signaling as a central mechanism. Prostaglandin signaling and macrophage chemotaxis suggest broader signal transduction, but the strongest theme is neural signaling and synaptic plasticity modulated by ERK pathways.","confidence":"High","size":26,"edges":317,"triangles":2418,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":16},{"id":"GO:0001963","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0006468","count":15},{"id":"GO:0048148","count":15}]},{"hash":"966507014458369086","title":"Neural Development and Synaptic Signaling","description":"The cluster is enriched for neural-related terms (visual perception, Schwann cell development, axonogenesis, excitatory postsynaptic potential), indicating roles in nervous system development and synaptic signaling; other terms reflect general proliferation but do not define a different primary function.","confidence":"Medium","size":26,"edges":11,"triangles":10,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":12},{"id":"GO:0009636","count":12},{"id":"GO:0014044","count":11},{"id":"GO:0000278","count":11},{"id":"GO:0060079","count":11}]},{"hash":"955685483883602219","title":"Neutrophil chemotaxis and cytokine signaling","description":"This cluster is dominated by GO terms related to innate immune responses to fungal origin, neutrophil chemotaxis, and various cytokine signaling pathways (TGF-beta, M-CSF), plus calcium signaling and STAT phosphorylation, all pointing to neutrophil-driven immune signaling and calcium-dependent signal transduction in response to fungal cues.","confidence":"High","size":26,"edges":315,"triangles":2375,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":23},{"id":"GO:0071560","count":14},{"id":"GO:0036006","count":14},{"id":"GO:0051281","count":14},{"id":"GO:0060444","count":14}]},{"hash":"2251662414191078565","title":"Inflammatory signaling and steroid response","description":"The cluster is dominated by GO terms related to inflammatory signaling and cytokine production (interleukin-1\u03b2 production, TNF-mediated signaling, pyroptotic inflammatory response) and cellular responses to glucocorticoids (dexamethasone stimulus). A couple of terms point to plant cell wall biosynthesis, which appear as minor outliers and may reflect annotation noise. Overall, the shared theme is immune/inflammatory signaling and steroid-responsive pathways.","confidence":"Medium","size":26,"edges":19,"triangles":3,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0009834","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0050718","count":2},{"id":"GO:0070269","count":2}]},{"hash":"138163760305537931","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by GO terms related to translation and ribosome assembly/biogenesis, including cytoplasmic translation, ribosomal small/large subunit assembly, and mitochondrial translation-related processes, plus SRP-dependent targeting and mitochondrial matrix import, indicating a core function in ribosome production and protein synthesis across compartments. An IL-4 response term appears incidental. ","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0000027","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006414","count":2},{"id":"GO:0030150","count":2}]},{"hash":"1561980960848669029","title":"Neural development and synapse assembly","description":"Dominant GO terms center on nervous system development, synapse assembly, and cell adhesion, with transmission of nerve impulse and actin cytoskeleton regulation through cell-cell adhesion supporting synaptic connectivity. The combination of homophilic/heterophilic adhesion and synapse-related regulation points to a cohesive neural development and synaptic wiring theme. A bone ossification term appears less representative of the cluster's main function.","confidence":"High","size":26,"edges":23,"triangles":1,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":16},{"id":"GO:0007399","count":15},{"id":"GO:0007157","count":15},{"id":"GO:0007156","count":14},{"id":"GO:0051965","count":13}]},{"hash":"2081757382132765013","title":"Glycosylation and glycan metabolism","description":"The top GO terms cluster around glycan processing and glycoprotein modification (N-glycan processing, protein sialylation, oligosaccharide metabolic process, glycosylceramide metabolism, and N-acetylneuraminate metabolism). A few terms reference development in olfactory and pollen contexts, which can be linked to glycoprotein roles in these processes, but the dominant theme is glycosylation and carbohydrate metabolism pathways. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006054","count":3},{"id":"GO:0071699","count":3},{"id":"GO:0006491","count":3},{"id":"GO:0021628","count":3},{"id":"GO:1990743","count":3}]},{"hash":"1960580972596714341","title":"Neural signaling and neuromuscular activation","description":"The cluster combines neural communication signals (GABA pathway, EPSP, conditioned taste aversion, locomotory behavior) with ion transport and skeletal muscle processes (Na+/K+ transport, skeletal muscle contraction/growth) and autonomic heart rate modulation, pointing to coordinated neuronal control of muscle activity.","confidence":"Medium","size":26,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":15},{"id":"GO:0071805","count":15},{"id":"GO:0007626","count":15},{"id":"GO:0060079","count":15},{"id":"GO:0007214","count":15}]},{"hash":"1613503341465560776","title":"RNA processing and stress-responsive metabolism","description":"Top GO terms emphasize RNA metabolism (deadenylation-independent decapping of nuclear-transcribed mRNA; translation; methylation) alongside nucleotide and folate metabolism (nicotinamide nucleotide metabolic process; tetrahydrofolate interconversion) and stress-related responses (response to ethanol; response to xenobiotic stimulus; response to glucocorticoid). This combination suggests a cohesive role in post-transcriptional regulation and metabolic adaptation under chemical or hormonal stress. ","confidence":"Medium","size":26,"edges":283,"triangles":1725,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0031087","count":4},{"id":"GO:0046496","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0045471","count":2}]},{"hash":"908177005554652269","title":"Chromatin regulation and transcription control","description":"Proteins here are linked to chromatin dynamics and transcription: negative regulation of RNA polymerase II transcription, chromatin remodeling linked to transcription initiation, heterochromatin formation, and histone methylation regulation, plus maintenance of sister chromatid cohesion. The cluster also includes nuclear mRNA decay and a note on protein localization to chromatin, supporting a nucleus-centric chromatin regulation theme, with some structural association via heterotetramerization. Overall, the dominant signal points to chromatin state control and transcriptional regulation.","confidence":"High","size":26,"edges":305,"triangles":2174,"max_degree":25,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0000122","count":22},{"id":"GO:0051290","count":19},{"id":"GO:0071169","count":15},{"id":"GO:0051572","count":14},{"id":"GO:0034184","count":14}]},{"hash":"451539325117167425","title":"Dopaminergic synaptic signaling and metabolic regulation","description":"This cluster is dominated by GO terms tied to dopamine signaling and uptake, including dopaminergic synaptic transmission and dopamine uptake, plus GPCR signaling and PI biosynthesis linked to dopamine receptors. Additional terms point to temperature/thermogenesis and blood pressure regulation, suggesting a neuronal module where dopamine signaling interfaces with metabolic and thermogenic regulation. The inclusion of energy-related processes (electron transport chain) likely reflects the energetic requirements of active dopaminergic signaling rather than a separate pathway. Overall, the terms align around dopamine receptor\u2013mediated signaling and its metabolic context.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":15},{"id":"GO:0035025","count":15},{"id":"GO:0045777","count":15},{"id":"GO:0001963","count":13}]},{"hash":"1219671696450343820","title":"Brain Adrenergic and Dopaminergic Signaling","description":"This cluster's top GO terms cluster around neural catecholamine signaling: dopaminergic synaptic transmission, adrenergic receptor signaling pathways, MAPK-activating adrenergic signaling, and related vascular regulation terms such as the brain renin-angiotensin system and norepinephrine-epinephrine\u2013mediated vasoconstriction. Together they point to central nervous system signaling by dopamine and norepinephrine/epinephrine, with implications for synaptic plasticity (long-term synaptic depression) and blood pressure regulation. A few terms about thymocyte differentiation or NADPH oxidase regulation appear less related and may reflect annotation noise.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":26},{"id":"GO:0001963","count":26},{"id":"GO:1900453","count":26},{"id":"GO:0001994","count":26},{"id":"GO:0071883","count":26}]},{"hash":"1267166206150799049","title":"Ribosome Biogenesis and Antiviral Response","description":"This cluster is dominated by GO terms for translation, cytoplasmic translation, ribosome biogenesis, and small subunit biogenesis, with additional terms linking RNA editing and antiviral regulation (interferon response, viral transcription, and genome replication). Together these suggest a group of proteins involved in ribosome assembly and protein synthesis, with an ancillary connection to RNA editing and innate antiviral defense.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0006364","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0042274","count":5},{"id":"GO:0035455","count":5}]},{"hash":"2032443671575625767","title":"Neural signaling and sensory perception","description":"This cluster\u2019s top GO terms are centered on neural communication and sensory functions: neuromuscular synaptic transmission, sensory perception of taste, and carotid body\u2013related hypoxic signaling, along with calcium-mediated signaling and smooth muscle contraction. Lipid-related terms (ether lipid metabolism, phospholipid transfer to membrane) suggest membrane-association aspects common to signaling proteins. While immune-related signaling is present, the dominant theme appears to be neural signaling and sensory processes, with lipid dynamics as a supporting facet. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":2},{"id":"GO:0001916","count":2},{"id":"GO:0007274","count":2},{"id":"GO:0003029","count":2},{"id":"GO:0050850","count":2}]},{"hash":"1905460272592062194","title":"Neural Development and GTPase Signaling","description":"In this cluster, the strongest GO terms center on neural development (neural tube closure, spinal cord development) and small GTPase signaling (positive regulation of GTPase activity, Rap protein signaling). This points to proteins involved in neural tissue formation and regulation of GTPase-driven signaling pathways. Additional terms like intracellular transport, proteolysis, and cell cycle regulation may reflect related cellular processes but do not override the core neural development and GTPase theme.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0008283","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0035948","count":3}]},{"hash":"1351879993752720815","title":"Ubiquitin-Proteasome Degradation & Circadian Regulation","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation, plus a notable term for regulation of circadian rhythm. These repeatedly point to regulated protein turnover as the core theme, with circadian control being a central functional context. Some neural development and proliferation-associated terms appear, likely reflecting broader roles of ubiquitin signaling in development, but the strongest signal is proteolysis linked to circadian regulation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042787","count":18},{"id":"GO:0042752","count":11},{"id":"GO:0031146","count":11},{"id":"GO:0021678","count":11},{"id":"GO:0051436","count":10}]},{"hash":"1919926149746207705","title":"Meiosis and Mitosis Regulation","description":"The top terms point to meiotic processes (meiotic spindle elongation, meiotic cell cycle regulation in oocyte maturation) and mitotic events (mitotic nuclear membrane reassembly), with supporting terms on nuclear import and signaling regulation (GTPase activity, MAPK/STAT pathways). This pattern suggests a cluster focused on cell division control across meiosis and mitosis, rather than a single specialized pathway.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0035167","count":1},{"id":"GO:0042518","count":1},{"id":"GO:0006607","count":1}]},{"hash":"1219329104781973922","title":"Neurodevelopment and Sensory Signaling","description":"The terms cluster around neural development and sensory function (spinal cord development, sensory perception of sound) with related neurotransmitter secretion and cytoskeletal/motility processes (microtubule-based movement). Signaling pathways like GPCR signaling and GTPase activation are also prominent, alongside occasional heart development and hypoxia responses, suggesting a broader developmental and sensory-signaling program rather than a single tissue-specific function.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0021510","count":4}]},{"hash":"1879651752541626487","title":"Unknown","description":"The top GO terms cover transcriptional regulation, neuronal development, protein ubiquitination, stress responses (cold), vitamin D response, glycerol metabolism, guard cell morphogenesis, phosphatidylglycerol catabolism, phosphate homeostasis, and DNA-templated transcription. These terms span diverse tissues and processes and do not point to a single cohesive functional theme for the protein cluster. Without a clear shared function, the cluster cannot be assigned a more informative label.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0031175","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0009409","count":3},{"id":"GO:0033280","count":3}]},{"hash":"589114861208561911","title":"Immune cell adhesion and cytoskeletal remodeling","description":"The top GO terms cluster around actin-driven processes (lamellipodium and filopodium assembly, cell spreading, GTPase activation) and adhesion, along with immune signaling (T cell activation via TCR-MHC interaction) and extracellular matrix involvement (hyaluronan metabolism). This suggests a cohesive theme of cytoskeletal remodeling and adhesion in immune cells, enabling movement and activation, despite one developmental term (midbrain morphogenesis) that is less directly connected. Overall, a plausible label is Immune cell adhesion and cytoskeletal remodeling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030212","count":19},{"id":"GO:0002291","count":19},{"id":"GO:1904693","count":15},{"id":"GO:0060313","count":15},{"id":"GO:0090630","count":15}]},{"hash":"811547642236213665","title":"Ubiquitination and Telomere Regulation Signaling","description":"This cluster centers on post-translational modification processes (ubiquitination and poly-ADP-ribosylation) and their connection to telomere maintenance regulation (via telomerase and telomere length control), suggesting a core theme of PTM-driven signaling influencing telomere biology. Additional terms indicate broader intracellular signaling, including mechanotransduction and synaptic plasticity, but the strongest cohesive signal is PTM-mediated signaling coupled with telomere regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":6},{"id":"GO:0007205","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0035556","count":5},{"id":"GO:0032212","count":5}]},{"hash":"1406103767892984553","title":"Unknown","description":"This cluster's GO terms cover cytoskeletal remodeling (lamellipodium assembly), mitochondrial dynamics (fusion, cristae formation), mRNA decay and processing, and immune signaling (ERK cascade, T cell proliferation). The diverse functions do not reveal a single cohesive biological theme, so a concise, representative label could not be determined.","confidence":"","size":25,"edges":23,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0010446","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0008053","count":2},{"id":"GO:0042407","count":2},{"id":"GO:1900153","count":2}]},{"hash":"1658557090614546975","title":"Cell adhesion and planar polarity in morphogenesis","description":"This cluster is enriched for cell-cell adhesion (heterophilic and homophilic), hemidesmosome assembly, and substrate adhesion-dependent spreading, along with terms related to planar polarity establishment and axon guidance. The convergence of adhesion and polarity signals points to a shared role in organizing tissue architecture and directional growth during development and morphogenesis. Some related terms about satellite cell activation and brown fat differentiation suggest broader tissue remodeling contexts but do not override the core adhesion/polarity theme.","confidence":"High","size":25,"edges":282,"triangles":1932,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":19},{"id":"GO:0031581","count":18},{"id":"GO:0034446","count":18},{"id":"GO:0014719","count":17},{"id":"GO:1904938","count":17}]},{"hash":"358241709966361092","title":"Developmental signaling and organogenesis","description":"The proteins show enrichment across multiple developmental and morphogen signaling pathways (Rho signaling, SHH/smoothened, ROBO/Roundabout, T cell receptor signaling) and processes such as myoblast fusion/differentiation, nervous system development, angiogenesis, and kidney development. This suggests a common theme of signaling-driven tissue development and organogenesis rather than a single specialized function, justifying a label centered on developmental signaling and organogenesis.","confidence":"Medium","size":25,"edges":188,"triangles":675,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":17},{"id":"GO:0007520","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0007224","count":16},{"id":"GO:0007399","count":16}]},{"hash":"1493765589027106851","title":"Post-transcriptional mRNA processing and translation control","description":"This cluster is enriched for splicing (spliceosome), polyadenylation, and mRNA stability regulation under stress, together with translation initiation/ preinitiation complex formation and IRES-dependent translation features, indicating a cohesive role in post-transcriptional gene expression regulation.","confidence":"High","size":25,"edges":218,"triangles":966,"max_degree":23,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":18},{"id":"GO:0045292","count":16},{"id":"GO:0010610","count":14},{"id":"GO:0002188","count":12},{"id":"GO:0075522","count":12}]},{"hash":"1672382207053718168","title":"Immune-vascular-bone development","description":"The top terms cluster around immune signaling (NF-kappaB regulation, cytokine production, mast cell degranulation, NK cell regulation), vascular biology (angiogenesis, endothelial cell-matrix adhesion), and skeletal/muscle development (ossification, myoblast fusion). This pattern suggests proteins coordinating immune responses with vascular remodeling and skeletal tissue formation, hence the label.","confidence":"Medium","size":25,"edges":38,"triangles":13,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0032516","count":9},{"id":"GO:0051092","count":9},{"id":"GO:0043303","count":9},{"id":"GO:0043931","count":9},{"id":"GO:0001525","count":8}]},{"hash":"2118358218056941323","title":"Neuronal synaptic plasticity and calcium signaling","description":"Top GO terms include long-term potentiation and long-term depression, synapse organization, excitatory postsynaptic potential, calcium ion import, mitochondrial calcium homeostasis, potassium ion transport, and receptor guanylyl cyclase signaling. These together point to proteins involved in neuronal synaptic signaling and plasticity, with calcium and ion regulation driving changes in synaptic strength. The presence of a behavior-related term supports neural circuit involvement. Overall, these terms define a cohesive neuronal synaptic plasticity module.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0050808","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0035641","count":3}]},{"hash":"2039717326921153216","title":"Ubiquitination and Histone Modification Signaling","description":"The top terms emphasize ubiquitination (autoubiquitination, K6-linked ubiquitination) and histone-related processes (histone catabolic process, H4-K16 acetylation), along with signaling pathways (JNK cascade, TNF-mediated signaling). This suggests a cluster of proteins involved in post-translational modification and chromatin regulation linked to immune signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":3},{"id":"GO:1901253","count":3},{"id":"GO:1903762","count":3},{"id":"GO:0085020","count":2},{"id":"GO:0036205","count":2}]},{"hash":"1743293394588653455","title":"Signaling and Cell Cycle Regulation","description":"The proteins in this cluster prominently feature GO terms tied to regulation of signaling pathways and cell cycle processes: positive regulation of kinase activity, regulation of MAPK and tyrosine phosphorylation, GTPase regulation, and meiotic cell cycle and spindle dynamics. Additional terms point to nuclear import and ciliary docking, suggesting roles in coordinating signaling with cellular architecture. Together these terms suggest a theme of regulatory proteins involved in signaling control and cell division/ciliogenesis-related processes, justifying a concise label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033674","count":7},{"id":"GO:0042518","count":6},{"id":"GO:0006607","count":6},{"id":"GO:0000188","count":6},{"id":"GO:0007084","count":6}]},{"hash":"1787908265570166668","title":"ER\u2013Golgi Trafficking and Wnt Secretion in Development","description":"The top GO terms cluster around ER-to-Golgi vesicle transport, COPI coating, regulation of ER exit, and retention in the ER lumen, together with positive regulation of Wnt protein secretion. These point to a cohesive secretory pathway function, particularly in processing and secreting signaling molecules like Wnt that drive developmental processes such as eye morphogenesis and axis specification. Some terms (e.g., amyloid-beta regulation, aggressive behavior) are less central and may reflect broader annotations, but the dominant theme is ER\u2013Golgi trafficking linked to developmental signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0048593","count":3},{"id":"GO:0002121","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0032525","count":2}]},{"hash":"281076048081534861","title":"Developmental signaling and immune regulation","description":"These proteins appear tied to signaling pathways that govern development (Notch signaling, dendrite development, cell migration) and immune responses (macrophage regulation, inflammatory protein production), with supporting transcriptional control (DNA-templated transcription, histone H3 acetylation) and membrane signaling components (calcium import, lipid metabolism). The combination points to a broad developmental-immune signaling module rather than a single, narrow function.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0050966","count":5},{"id":"GO:0010745","count":5},{"id":"GO:0043966","count":5},{"id":"GO:2000171","count":4}]},{"hash":"15420991037810090","title":"TORC1-Driven Translation and Development Signaling","description":"The top GO terms cluster around TORC1 signaling and regulation of translation initiation (formation of the preinitiation complex, translation reinitiation) and mRNA transport, plus GTPase activity regulation and dephosphorylation. This points to a cohesive theme of growth and cellular control coordinated by TORC1 and translation machinery, further echoed by mitotic cell cycle and developmental processes such as neural tube closure and multicellular development. While there are peripheral terms like defense response, the dominant signal is TORC1-linked control of translation and development.","confidence":"High","size":25,"edges":8,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":8},{"id":"GO:0038202","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0051028","count":7},{"id":"GO:0070262","count":7}]},{"hash":"1884326105889743893","title":"Hormone-regulated brain development and glycinergic signaling","description":"Most terms point to brain development and hormone signaling (thalamus and striatum development; male differentiation and prostate development; steroid receptor complex assembly). The glycine transport and glycinergic synaptic regulation indicate a neural signaling component, complemented by glial-related growth, suggesting a hormone-regulated neural development program with emphasis on inhibitory glycinergic neurotransmission.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0006463","count":7},{"id":"GO:0046661","count":7},{"id":"GO:0030850","count":7},{"id":"GO:0021794","count":6}]},{"hash":"945753669743704519","title":"Developmental and immune signaling cluster","description":"These proteins show a mix of developmental processes (angiogenesis, cardiac neural crest cell development) and cell-cycle/signaling roles (spindle assembly, MAPKK-related activity, histone phosphorylation regulation), along with innate immune responses (response to dsRNA, response to muramyl dipeptide). The convergence of developmental, signaling, and immune terms suggests a broad signaling hub rather than a single pathway. ","confidence":"Medium","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":25},{"id":"GO:0090606","count":25},{"id":"GO:0000186","count":25},{"id":"GO:0061308","count":25},{"id":"GO:0001525","count":25}]},{"hash":"507304234661823649","title":"Cytoskeletal dynamics and cell migration signaling","description":"Top terms converge on actin remodeling and signaling pathways that govern movement and polarity (lamellipodium and actin bundle assembly, Rho/GTPase signaling, epithelial polarity), with supporting pathways like Wnt and ephrin signaling and receptor-mediated regulation of synaptic plasticity. Together, these indicate a cluster centered on cytoskeletal dynamics driving migration and cell polarity.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:1900383","count":5},{"id":"GO:1901187","count":5},{"id":"GO:0016477","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0016055","count":5}]},{"hash":"1936412591444502881","title":"Cardiovascular signaling and cytoskeletal dynamics","description":"The proteins are enriched for GO terms linking heart development, blood vessel remodeling, insulin signaling, and cytoskeletal regulation (Rho/Ras, stress fibers, spindle assembly). This suggests a theme around cardiovascular signaling coupled with cytoskeletal organization and metabolic signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0043552","count":6},{"id":"GO:0007507","count":5},{"id":"GO:0046580","count":5},{"id":"GO:0008286","count":4}]},{"hash":"1888334933791052065","title":"Developmental signaling and actin cytoskeleton remodeling","description":"This cluster shows enrichment for developmental and signaling processes (e.g., TGF-beta response, insulin receptor signaling, interferon signaling, small GTPase signaling) alongside cytoskeletal dynamics (actin filament branching) and cell junction localization, with a note on heart development. Together, these terms suggest a theme of coordinated signaling governing cell adhesion, movement, and developmental processes, rather than a single specific pathway.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006915","count":10},{"id":"GO:0071896","count":7},{"id":"GO:1900042","count":7},{"id":"GO:0071560","count":7},{"id":"GO:0090135","count":7}]},{"hash":"1442997438611395425","title":"Cytoskeletal remodeling in vessels and leukocytes","description":"The top GO terms emphasize cytoskeletal assembly processes (stress fibers, microspikes, spindle organization) and regulatory roles in endothelial and leukocyte functions (vascular permeability, cellular extravasation, neutrophil degranulation, respiratory burst). This points to a shared theme of cytoskeleton-driven control of cell movement, barrier dynamics, and immune cell activity in vascular contexts, with additional terms reflecting broader developmental and cellular organization roles that can relate to cytoskeletal regulation. While some terms are broader or pleiotropic, the strongest common thread is actin- and microtubule-associated remodeling governing vascular-immune interactions. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060313","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0060268","count":3},{"id":"GO:0002692","count":3}]},{"hash":"619297065935971255","title":"Epithelial junctions and actin remodeling","description":"The top GO terms cluster around epithelial cell-cell adhesion, apical junction assembly, and lamellipodium assembly, which point to junction formation and actin cytoskeleton remodeling in epithelial cells. Additional terms on Rho signaling regulation and exocytosis-related processes fit with coordinated junctional complexes and membrane trafficking. This suggests a cohesive role in epithelial adhesion structures coupled with cytoskeletal dynamics.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":4},{"id":"GO:0035994","count":3},{"id":"GO:0043297","count":3},{"id":"GO:0030032","count":3},{"id":"GO:0090136","count":3}]},{"hash":"59600995245929798","title":"Glutamatergic Synaptic Signaling and Plasticity Regulation","description":"This cluster is dominated by GO terms related to glutamatergic synaptic transmission and neurotransmitter secretion, with entries indicating regulation of synaptic plasticity and apoptosis in neural contexts. While a few terms (e.g., myoblast fusion, plant ABA signaling) appear less connected to neurons, the strongest signals point to neuronal communication and modulation of plasticity and cell survival, suggesting a cohesive theme around glutamatergic signaling and its control of synaptic function and apoptosis.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035249","count":10},{"id":"GO:0043065","count":9},{"id":"GO:0016525","count":9},{"id":"GO:0007269","count":9},{"id":"GO:0034351","count":9}]},{"hash":"144715249184811425","title":"Embryonic Development and Transcription Regulation","description":"This cluster centers on embryonic development and organogenesis, evidenced by pancreas, hypothalamus, neural crest migration, digestive tract morphogenesis, and ureteric bud branching terms. Coupled with GO terms for transcriptional control (RNA Pol II repression, chromatin remodeling, DNA-templated transcription), it points to coordinated regulation of gene expression driving development.","confidence":"High","size":25,"edges":203,"triangles":813,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":19},{"id":"GO:0031018","count":14},{"id":"GO:0001755","count":13},{"id":"GO:0090190","count":13},{"id":"GO:0048557","count":13}]},{"hash":"558603119841879019","title":"Cardiac contraction and calcium signaling","description":"This cluster\u2019s top terms are dominated by heart development and regulation of cardiac muscle contraction via calcium release (e.g., GO:0010881), along with related cytoskeletal and electrical activity aspects such as actin crosslinking and clustering of voltage-gated potassium channels. While there are a few immune signaling references, the strongest, recurring themes knit around cardiomyocyte function, calcium-dependent contraction, and related signaling pathways, suggesting a coherent cardiac-centric function for this set. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0038095","count":4},{"id":"GO:0051764","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0010881","count":3}]},{"hash":"892855770037305755","title":"Neural cell adhesion and synapse formation","description":"Top terms cluster around neuronal cell adhesion and synapse organization, including heterophilic/homophilic CAMs, paranodal junction assembly, and transmission of nerve impulses. Immune-related terms appear as ancillary signals (immunoglobulin production, NK cell regulation, complement activation), suggesting a neural-immune interaction context alongside synaptic connectivity. Thus, Neural cell adhesion and synapse formation is a reasonable label.","confidence":"Medium","size":25,"edges":5,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":6},{"id":"GO:0030913","count":6},{"id":"GO:0019226","count":6},{"id":"GO:0002859","count":5}]},{"hash":"1425761094925394379","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms center on developmental processes across multiple tissues: left-right pattern formation; placental and trophoblast differentiation; endocrine system development; cartilage morphogenesis; and EMT in heart development. This points to a broad but coherent theme of embryonic patterning and tissue morphogenesis, with additional splicing and transcription regulation terms likely reflecting general gene expression control during development.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":22},{"id":"GO:0060806","count":22},{"id":"GO:0060707","count":22},{"id":"GO:0035270","count":22},{"id":"GO:0003323","count":22}]},{"hash":"1426805406547260032","title":"DNA replication and transcription regulation cluster","description":"Dominant terms center on DNA replication, G1/S cell-cycle transition, and DNA-templated transcription, with negative regulation of RNA Pol II\u2014pointing to genome maintenance and transcription control during the cell cycle. A few terms reflect unrelated processes (X-ray response, tissue-specific growth) adding noise, but the core theme remains replication/transcription regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0000082","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0010165","count":3},{"id":"GO:0006351","count":3}]},{"hash":"644429505983626518","title":"Steroid and Prostaglandin Biosynthesis","description":"This cluster is dominated by GO terms for prostaglandin biosynthesis, steroid hormone metabolism (androgen, progesterone, aldosterone), and related P450 omega-hydroxylase pathways, pointing to lipid mediator and steroid biosynthesis. Additional terms touch on female gonad development, endothelial adhesion, and stress responses, which fit with hormonal regulation and tissue remodeling, but the central theme is lipid-derived signaling and hormone production.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":17},{"id":"GO:0097267","count":17},{"id":"GO:0033076","count":17},{"id":"GO:0008585","count":17},{"id":"GO:0035902","count":17}]},{"hash":"2144689159766140676","title":"Mitochondrial translation and respiration assembly","description":"Most terms point to mitochondria-focused processes: mitochondrial translation and general translation, alongside components of the respiratory chain (electron transport, ubiquinone biosynthesis, complex IV assembly) and protein import into the intermembrane space. This suggests a cluster representing mitochondrial protein synthesis, maturation, and assembly of the respiratory machinery.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":2},{"id":"GO:0006412","count":2},{"id":"GO:1904808","count":2},{"id":"GO:0006744","count":2},{"id":"GO:0090503","count":2}]},{"hash":"300134767796693323","title":"Ribosome Biogenesis and Translation","description":"This cluster is enriched for GO terms tied to making ribosomes and synthesizing proteins (ribosome biogenesis, cytoplasmic translation, translation, ribosomal subunit export, tRNA modification). While there are related terms about cell cycle and stress responses, the strongest common theme across proteins is involvement in ribosome assembly and the protein synthesis machinery, indicating a cohesive group.","confidence":"Medium","size":25,"edges":37,"triangles":65,"max_degree":9,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0007049","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0006412","count":5},{"id":"GO:0046677","count":4},{"id":"GO:1903833","count":3}]},{"hash":"1185930856831358662","title":"Innate Immune\u2013Vascular Remodeling","description":"This cluster spans innate immune processes (innate immune response, immunological synapse formation, receptor-mediated endocytosis, acute inflammatory response) along with endothelial migration, sprouting angiogenesis, collagen fibril organization, and tricellular tight junction assembly, suggesting inflammation-driven vascular remodeling with macrophage activity and apoptotic cell clearance.","confidence":"Medium","size":25,"edges":26,"triangles":6,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":10},{"id":"GO:0043277","count":10},{"id":"GO:0030199","count":8},{"id":"GO:0010744","count":8},{"id":"GO:0043542","count":8}]},{"hash":"618369912502264900","title":"Glycan biosynthesis and processing","description":"The top GO terms cluster around glycosylation and glycan metabolism, including N-glycan processing, N-linked glycosylation via asparagine, protein sialylation, oligosaccharide metabolism, glycosylceramide metabolism, and N-acetylneuraminate metabolism. This points to a cohesive theme of glycan synthesis and post-translational modification of proteins and lipids. Some Plant/Development terms (pollen-related) may reflect broader roles of glycoproteins or annotation noise, but the central signal is glycan-related pathways.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006054","count":5},{"id":"GO:0071699","count":5},{"id":"GO:0006491","count":5},{"id":"GO:0021628","count":5},{"id":"GO:1990743","count":5}]},{"hash":"1729133399705970153","title":"Renal Hormone and Metabolic Pathways","description":"The cluster is strongly enriched for kidney-related terms, notably inner medullary collecting duct development and renal water homeostasis, and also shows broad metabolic/hormonal activity including prostaglandin, androgen, and progesterone biosynthesis/metabolism, glutathione biosynthesis, and doxorubicin metabolism, suggesting a kidney-centered set of proteins involved in both metabolism and hormone processing.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":25},{"id":"GO:0001516","count":25},{"id":"GO:0006750","count":25},{"id":"GO:0072061","count":25},{"id":"GO:0044598","count":25}]},{"hash":"1311198790739938036","title":"Neuroinflammatory signaling and sphingolipid metabolism","description":"The terms converge on inflammatory signaling (NF-kappaB canonical and non-canonical, IL-1\u03b2 production) and sphingolipid metabolism (sphingosine biosynthesis and catabolism), with kinase regulation implied by peptidyl-threonine phosphorylation. Brain development and fibroblast proliferation hints place this in a neural-growth/inflammatory signaling context, consistent with a cohesive module involving neuroinflammation and lipid signaling. Overall, the cluster seems to reflect a specific, biologically plausible theme rather than random term aggregation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010800","count":6},{"id":"GO:0046521","count":6},{"id":"GO:0046512","count":6},{"id":"GO:0051092","count":6},{"id":"GO:2000182","count":6}]},{"hash":"1355764550320105377","title":"Cell Cycle and Lipid Metabolism Regulation","description":"The top GO terms cluster around nuclear organization and transcriptional control (nucleus organization; positive regulation of transcription by RNA polymerase II; lamin depolymerization), alongside signals governing cell cycle progression (positive regulation of G1/S transition) and cytoskeletal/nuclear dynamics (Rho signaling, lamin changes). There is also a strong lipid metabolism theme (lipid droplet organization; fatty acid catabolic process; triglyceride biosynthesis; ER organization), suggesting coordinated regulation of cell cycle progression with lipid/ER/nuclear infrastructure. This points to a module that links nuclear/cell-cycle control with lipid metabolism and organelle organization.","confidence":"Medium","size":25,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006997","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0071320","count":3},{"id":"GO:0035023","count":3},{"id":"GO:1900087","count":3}]},{"hash":"2260613983658345904","title":"Unknown","description":"The top GO terms span neuronal functions (learning, synapse organization, receptor internalization) but also include plant-specific metabolism (gibberellic acid signaling, raffinose biosynthetic process, cellulose catabolic process), lipid and xenobiotic responses, and other unrelated processes. This mix suggests there is no single cohesive function or pathway tying all 25 proteins together, so a specific, representative label cannot be confidently assigned.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0007612","count":8},{"id":"GO:0031623","count":8},{"id":"GO:0050808","count":8},{"id":"GO:0050783","count":8},{"id":"GO:0009740","count":8}]},{"hash":"204031712627359989","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":7},{"id":"GO:0019243","count":5},{"id":"GO:0031126","count":5},{"id":"GO:0034414","count":5},{"id":"GO:0046929","count":5}]},{"hash":"1146535677081627203","title":"Ubiquitin-Dependent Protein Degradation & Antiviral Immunity","description":"The cluster is dominated by ubiquitination-related GO terms (ubiquitin-dependent proteolysis, autoubiquitination, K63- and K48-linked ubiquitination) and degradation pathways (including ERAD), with concurrent innate immune and antiviral defense terms and regulation of JNK signaling, suggesting a cohesive role in ubiquitin-mediated protein turnover linked to antiviral responses.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0051865","count":14},{"id":"GO:0070534","count":11},{"id":"GO:1903762","count":11},{"id":"GO:1901253","count":11}]},{"hash":"1866786401287674596","title":"P450-Mediated Hormone and Xenobiotic Metabolism","description":"This cluster centers on metabolic processes involving hormones (androgen, progesterone, prostaglandin) and xenobiotics (carbazole, isoquinoline alkaloids) with prominent omega-hydroxylase P450 pathway activity, suggesting cytochrome P450\u2013driven metabolism as a unifying theme. Some other terms like endothelial adhesion or stress responses are present but less central to the dominant pathway signal.","confidence":"High","size":25,"edges":261,"triangles":1540,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0046232","count":21},{"id":"GO:0001516","count":20},{"id":"GO:0097267","count":20},{"id":"GO:0033076","count":20},{"id":"GO:0008585","count":20}]},{"hash":"239355132540297618","title":"Coagulation and ECM remodeling","description":"The top terms cluster around blood coagulation, regulation of fibrinolysis, and ECM-related processes such as collagen fibril organization and secretion of ECM components, with supporting hints from epithelial morphogenesis and kidney development. This pattern indicates a cohesive module linking coagulation/hemostasis to extracellular matrix remodeling during tissue morphogenesis. ","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0051918","count":7},{"id":"GO:0010757","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0003331","count":7},{"id":"GO:0042730","count":7}]},{"hash":"1595037506887152211","title":"Embryonic development and morphogenesis","description":"The terms cluster around embryogenesis, including craniofacial and mesoderm patterning, EMT in heart cushion formation, placenta-related differentiation, cartilage morphogenesis, and broader organ system development, indicating a cohesive theme of early development and tissue morphogenesis.","confidence":"High","size":25,"edges":24,"triangles":0,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":23},{"id":"GO:0060972","count":22},{"id":"GO:0003198","count":22},{"id":"GO:0035270","count":22},{"id":"GO:0003323","count":22}]},{"hash":"1991691734050267896","title":"Meiotic Chromosome Cohesion & Synaptonemal Complex","description":"Based on the top GO terms, the cluster is dominated by meiotic chromosome organization processes: centromeric sister chromatid cohesion, chromosome condensation, and synaptonemal complex assembly. Other signals like TORC1 and SREBP pathways are present but less central, suggesting these proteins mainly function in meiotic chromosome cohesion and synapsis rather than broader signaling or development roles. ","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":3},{"id":"GO:0032933","count":3},{"id":"GO:0038202","count":2},{"id":"GO:0010032","count":2},{"id":"GO:0007130","count":2}]},{"hash":"1578096855193491238","title":"Electrical signaling and mechanosensation in excitable cells","description":"This cluster centers on terms related to electrical activity regulation (SA node action potential, positive regulation of electrical coupling) and mechanosensory processes (response to muscle stretch, cellular response to mechanical stimulus, detection of mechanical stimulus involved in pain), with supporting hints from synaptic receptor localization. Together, they point to signaling pathways in excitable cells that integrate electrical and mechanical cues. A few immune-related terms appear but do not dominate the theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":8},{"id":"GO:0045083","count":7},{"id":"GO:0035994","count":7},{"id":"GO:0072660","count":7},{"id":"GO:1900383","count":7}]},{"hash":"219579194877300135","title":"Vascular Inflammation and Coagulation Signaling","description":"The top GO terms are dominated by blood coagulation and inflammatory response, with concurrent signs of vascular tone control (vasoconstriction, smooth muscle contraction) and GPCR-mediated signaling and pain perception. This suggests a functional cluster centered on vascular inflammatory/coagulation pathways and associated signaling; the developmental terms present may reflect broader roles or annotation spillover but do not override the core theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":20},{"id":"GO:0006954","count":20},{"id":"GO:0045986","count":19},{"id":"GO:0060658","count":19},{"id":"GO:0045745","count":19}]},{"hash":"332689229951674583","title":"TLR-driven innate immune signaling","description":"The top GO terms are dominated by toll-like receptor pathways (TLR2/4), LPS signaling, neutrophil chemotaxis, and TNF production, all pointing to innate immune activation and inflammatory responses. A few terms (DNA replication, prospore assembly) are unrelated noise, but the strongest shared function across the cluster is innate immune signaling via TLRs and downstream inflammatory processes.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030593","count":3},{"id":"GO:0010596","count":3},{"id":"GO:0045060","count":3},{"id":"GO:0031321","count":3},{"id":"GO:0006260","count":3}]},{"hash":"804133526390032592","title":"Wnt signaling and PARP-telomere regulation","description":"This cluster shows a clear signal for the Wnt pathway, with concurrent enrichment for PARP-related ADP-ribosylation and several telomere-related terms (telomerase maintenance, telomere capping, telomere length regulation). The presence of synaptic plasticity and mechanical response terms suggests broader signaling roles, but the combination of Wnt signaling with telomere maintenance and PARP activity provides a cohesive theme centered on signaling connected to telomere regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":5},{"id":"GO:0032212","count":3},{"id":"GO:0070212","count":3},{"id":"GO:1904355","count":3},{"id":"GO:1900383","count":3}]},{"hash":"1507629672912986698","title":"Embryonic Development and Organogenesis","description":"The terms cluster around developmental processes across multiple tissues (pancreas, placenta, heart, cartilage) including patterning, EMT, and angiogenesis, with transcriptional regulation\u2014pointing to a cohesive theme of embryogenesis and organ formation.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060972","count":7},{"id":"GO:0060806","count":7},{"id":"GO:0060707","count":7}]},{"hash":"1391059766148527661","title":"Embryogenesis and Tissue Morphogenesis","description":"This cluster is dominated by GO terms spanning broad embryonic development and tissue morphogenesis across multiple tissues (mesoderm, pancreas, cartilage, hair follicles, palate, placenta/t trophoblast), plus patterning and EMT events, suggesting a general developmental/morphogenetic program rather than a single pathway.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":25},{"id":"GO:0060806","count":25},{"id":"GO:0035270","count":25},{"id":"GO:0060707","count":25},{"id":"GO:0003323","count":25}]},{"hash":"1674483432559919253","title":"Unknown","description":"The top GO terms cover a mix of cell wall breakdown, pathogen defense, viral release, energy production, signaling, and even locomotion, with no single unifying function emerging. Because the terms point to diverse, non-overlapping processes rather than a coherent biological theme, a concise, meaningful label cannot be assigned beyond Unknown.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0016998","count":11},{"id":"GO:0009253","count":11},{"id":"GO:0019076","count":11},{"id":"GO:0022900","count":11},{"id":"GO:0007626","count":11}]},{"hash":"219730661899838863","title":"Adrenergic signaling and calcium mobilization in brain","description":"The top GO terms cluster around adrenergic receptor signaling (MAPK-activating and phospholipase C-activating pathways), calcium release into the cytosol, dopaminergic synaptic transmission, brain renin-angiotensin system, and vasoconstriction related to blood pressure regulation. Taken together, these points highlight neuronal signaling and intracellular calcium dynamics driven by adrenergic input. A few immune-related terms appear but are less central to the main theme. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":23},{"id":"GO:0002035","count":22},{"id":"GO:0001963","count":22},{"id":"GO:1900453","count":22},{"id":"GO:0001994","count":22}]},{"hash":"673926323892229744","title":"Cytoskeletal dynamics and signaling","description":"This cluster\u2019s top terms largely relate to cytoskeleton remodeling and signaling\u2014positive regulation of GTPase activity, actin filament depolymerization, mitotic spindle assembly, and neuron projection development\u2014pointing to cytoskeletal dynamics influencing cell shape, division, and neural development. While several terms touch on development, transcriptional regulation, or immunity, the strongest and most cohesive thread is cytoskeletal regulation alongside signaling pathways (e.g., TGF-beta). ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0008584","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0071560","count":5},{"id":"GO:0043966","count":5}]},{"hash":"1525212785587495345","title":"Glutamatergic Synaptic Transmission","description":"The cluster is dominated by GO terms related to neuronal communication and excitatory signaling, including neuron projection development, transmission of nerve impulse, ionotropic glutamate receptor signaling, and excitatory postsynaptic potentials, with potassium ion transport supporting neuronal excitability. A couple of outlier terms exist, but the overall theme aligns with glutamatergic synaptic signaling.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":2},{"id":"GO:0019226","count":2},{"id":"GO:0050806","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0016998","count":2}]},{"hash":"477553162940798307","title":"Glycolysis and central carbon metabolism with redox stress","description":"This cluster is dominated by core energy-producing pathways (glycolysis, oxaloacetate metabolism, glyoxylate cycle) and redox/oxidative stress responses (NADH-related processes, hydrogen peroxide response, hypoxia), with additional nutrient-response signals, indicating a cohesive module of energy metabolism tied to oxidative stress adaptation.","confidence":"High","size":24,"edges":271,"triangles":1920,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006107","count":9},{"id":"GO:0007584","count":8},{"id":"GO:0006096","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0019878","count":7}]},{"hash":"813982187897815149","title":"Neuronal Ion Channels and Synaptic Signaling","description":"The cluster is strongly enriched for neuronal-related processes: sodium and potassium ion transmembrane transport, GABA signaling, excitatory postsynaptic potentials, and receptor internalization, all pointing to ion-channel\u2013driven synaptic transmission and plasticity. Additional terms on cellular responses to electrical stimuli and regulation of long-term synaptic plasticity reinforce a neural signaling theme, while locomotory behavior and sensory system development (posterior lateral line) suggest involvement in neural circuits governing movement and sensory processing. This combination supports a cohesive label centered on neuronal signaling and ion transport.","confidence":"High","size":24,"edges":13,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":23},{"id":"GO:0001661","count":22},{"id":"GO:0071805","count":22},{"id":"GO:0007626","count":22},{"id":"GO:0060079","count":22}]},{"hash":"1040803820616607603","title":"NLRP3 inflammasome activation and pyroptosis","description":"The cluster is dominated by GO terms tied to the NLRP3 inflammasome complex assembly and downstream inflammatory processes, including IL-1\u03b2 and IL-18 production and pyroptotic inflammatory responses, all part of innate immune activation. A few terms about Th17 differentiation and general innate immunity further support a cohesive inflammatory signaling module, despite one spurious term related to mitotic spindle assembly. Confidence is high that this label captures the core function of the cluster. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0044546","count":13},{"id":"GO:0032611","count":13},{"id":"GO:2000321","count":13},{"id":"GO:0050718","count":13},{"id":"GO:1990001","count":13}]},{"hash":"1620448232874464251","title":"Germline and hematopoietic differentiation","description":"The top GO terms cluster around differentiation and development across germline and blood/immune lineages, including germline cyst encapsulation and egg chamber follicle structures, embryonic cell-cycle regulation, and differentiation of granulocytes, macrophages, erythrocytes, and megakaryocytes. This suggests a shared theme of lineage-specific developmental regulation rather than a single pathway, making Germline and hematopoietic differentiation a concise and representative label.","confidence":"Medium","size":24,"edges":5,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":6},{"id":"GO:0048706","count":5},{"id":"GO:0007347","count":5},{"id":"GO:0030713","count":5},{"id":"GO:0030851","count":5}]},{"hash":"261844773362132891","title":"Actin Patch Assembly and Endocytosis","description":"The cluster is strongly enriched for GO terms related to actin cytoskeleton dynamics (actin cortical patch assembly, actin filament polymerization, patch localization) and endocytic processes (regulation of endocytosis, phagocytosis), indicating a set of proteins involved in actin-driven endocytosis and patch formation. Peripheral terms about development and fungal structures are likely incidental; the dominant theme is actin-mediated endocytosis machinery.","confidence":"High","size":24,"edges":27,"triangles":27,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000147","count":4},{"id":"GO:0006348","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0021762","count":4},{"id":"GO:0030041","count":3}]},{"hash":"2056616578764883144","title":"ECM remodeling and tissue development","description":"The cluster prominently features processes tied to extracellular matrix remodeling (basement membrane disassembly, bone resorption, proteolysis) and extracellular signaling (Wnt localization to extracellular region), alongside developmental contexts (lung branching, decidualization). Immune and neuropeptide catabolic terms are present as well, suggesting a broad ECM-remodeling and development-associated theme across tissues.","confidence":"Medium","size":24,"edges":271,"triangles":1921,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":22},{"id":"GO:0035593","count":22},{"id":"GO:0051603","count":22},{"id":"GO:0034769","count":22},{"id":"GO:0097067","count":22}]},{"hash":"1176046778861750265","title":"Transmembrane Transporters","description":"This cluster is characterized by GO terms for transmembrane transport of ions and small molecules (e.g., sodium, nitrate, nitrite, phosphate) and substrates like sugars and xenobiotics, plus neurotransmitter loading into vesicles, indicating a cohesive set of membrane transporter proteins.","confidence":"High","size":24,"edges":87,"triangles":48,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":6},{"id":"GO:0015707","count":6},{"id":"GO:0015751","count":6},{"id":"GO:0015739","count":6},{"id":"GO:0035435","count":6}]},{"hash":"720748997573965956","title":"Bacterial sugar catabolism network","description":"Based on the top GO terms, the majority describe catabolic and biosynthetic processes for various carbohydrates (rhamnose, arabinose, glycerol, xylulose, gluconate, glucuronate) and related phosphorylation, pointing to a cluster centered on sugar metabolism. The quorum sensing term reinforces a bacterial context; an immune-response term (interleukin-13) may be incidental. Overall, the cluster appears to reflect diverse bacterial carbohydrate catabolism pathways rather than a single specific pathway.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046835","count":11},{"id":"GO:0019301","count":8},{"id":"GO:0046167","count":8},{"id":"GO:0019563","count":8},{"id":"GO:0005998","count":8}]},{"hash":"1473569897408147554","title":"Hair follicle development and skin patterning","description":"The set is dominated by terms related to hair follicle placode formation, maintenance of organ identity, and Wnt signaling regulation, all central to follicle development and epidermal patterning. Additional terms about cell cycle control, apoptosis, and cell migration reflect morphogenetic remodeling during this developmental process. Thus, the strongest thematic thread is hair follicle development with associated skin patterning.","confidence":"High","size":24,"edges":271,"triangles":1918,"max_degree":23,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":13},{"id":"GO:0043065","count":12},{"id":"GO:0016477","count":12},{"id":"GO:0008285","count":12},{"id":"GO:0090090","count":12}]},{"hash":"1452844143837884654","title":"Ribosome Biogenesis and rRNA Processing","description":"This cluster is enriched for ribosome biogenesis, rRNA maturation/processing (LSU/ITS1 cleavage), rRNA base methylation, and translation, pointing to a coherent function in ribosome assembly and protein synthesis; occasional cell-division related terms may reflect growth coordination with ribosome production.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":9},{"id":"GO:0000463","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0035948","count":3},{"id":"GO:0070475","count":3}]},{"hash":"537521315686494943","title":"Calcium-NFAT signaling in muscle and heart","description":"The cluster is dominated by calcium handling and signaling terms tied to muscle and heart biology: calcium ion transport, ryanodine receptor activity, skeletal muscle fiber development, and cardiac muscle hypertrophy in response to stress, plus regulation of the calcineurin-NFAT signaling cascade. These together point to a cohesive module where Ca2+ signals activate NFAT-driven transcription to promote muscle growth and stress responses. A few terms relate to other processes (neural development, mitosis) but the core pattern remains calcium-dependent muscle/heart signaling. ","confidence":"High","size":24,"edges":10,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048741","count":16},{"id":"GO:0021762","count":16},{"id":"GO:0060316","count":15},{"id":"GO:0000272","count":14},{"id":"GO:0014898","count":14}]},{"hash":"1844077752995117381","title":"Neural morphogenesis and cytoskeletal signaling","description":"The Top Terms cluster around actin cytoskeleton reorganization, axon extension and axonogenesis regulation, dendrite morphogenesis, and signaling cascades such as ERK and Wnt, all pointing to neuronal development and cytoskeletal remodeling driven signaling. While a few immune-related terms (T cell receptor signaling, mast cell degranulation) appear, the dominant theme is neural morphogenesis and cytoskeletal dynamics, with some related phosphorylation and cell-cycle terms likely reflecting shared signaling networks rather than core function. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031532","count":17},{"id":"GO:0045773","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0090263","count":16}]},{"hash":"1722782095053667136","title":"Neuronal RNA processing and translation regulation with antiviral response","description":"The cluster is enriched for translation, mRNA processing, rRNA catabolic processes, and regulation of translation initiation (including eIF2\u03b1 phosphorylation), indicating RNA-level control of gene expression. It also includes neuronal development terms (motor neuron apoptosis, motor behavior, spinal cord morphogenesis) and innate immune/antiviral terms (innate immune response, negative regulation of viral genome replication, siRNA processing), suggesting a cohesive theme of RNA processing/translation control in neurons with antiviral defense functions.","confidence":"Medium","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0097049","count":10},{"id":"GO:0061744","count":10},{"id":"GO:0006397","count":10},{"id":"GO:0045087","count":10}]},{"hash":"2118453096088472472","title":"Diverse signaling and developmental processes","description":"This cluster shows a mix of GO terms spanning signaling pathways (MAPKK-related, spindle assembly regulation, general signal transduction), developmental contexts (angiogenesis, cardiac neural crest cell development in heart development), and stress/immunity responses (response to dsRNA, response to muramyl dipeptide) plus apoptosis regulation. There isn\u2019t a single cohesive function, but a broad theme around signaling and developmental/stress-related processes.","confidence":"Medium","size":24,"edges":267,"triangles":1832,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":24},{"id":"GO:0090606","count":24},{"id":"GO:0000186","count":24},{"id":"GO:0061308","count":24},{"id":"GO:0001525","count":24}]},{"hash":"2232988316089166351","title":"Cardiac morphogenesis and endothelial differentiation","description":"The cluster prominently includes GO terms tied to heart development and vascular differentiation, such as cardiac right atrium morphogenesis, venous endothelial cell differentiation, and Notch signaling in heart-field regulation, with supporting cell adhesion terms. While inflammatory and grooming-behavior terms appear, the core signal centers on cardiac morphogenesis and endothelial specification.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043113","count":12},{"id":"GO:2000821","count":12},{"id":"GO:0071260","count":10},{"id":"GO:0006954","count":9},{"id":"GO:0032496","count":9}]},{"hash":"1284677193689352494","title":"Cell Adhesion and Development","description":"Most top GO terms point to cell-cell adhesion (heterophilic and homophilic) and developmental processes such as bone ossification, multicellular organism development, sprouting angiogenesis, and synapse assembly. A few terms relate to defense and ion transport, but the dominant pattern is proteins involved in establishing tissue interfaces and guiding tissue morphogenesis.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0043931","count":10},{"id":"GO:0000187","count":9},{"id":"GO:0042742","count":9},{"id":"GO:0002042","count":8}]},{"hash":"1314195304523639438","title":"Cellular energy, gene expression, and proteostasis","description":"This cluster links mitochondrial redox balance and electron transport with nuclear gene expression (translation, transcription) and protein quality control (ubiquitin-proteasome, ERAD, chaperones, heat response), indicating cellular homeostasis through energy, expression, and proteostasis.","confidence":"Medium","size":24,"edges":265,"triangles":1813,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006120","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1960794265701368471","title":"Neuronal GTPase signaling and synaptic trafficking","description":"This cluster is dominated by GO terms about regulation of GTPase activity (Rho/Rac/Ras) and neuronal processes such as synaptic vesicle budding and neurotransmitter receptor transport, pointing to a shared theme of GTPase-driven signaling shaping synaptic function and neuronal behavior.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0035023","count":5},{"id":"GO:0008344","count":4},{"id":"GO:0016185","count":4},{"id":"GO:0046580","count":4}]},{"hash":"2125838179213586487","title":"Neuronal mitochondrial respiration and axonogenesis","description":"These terms cluster on mitochondrial functions (complex IV assembly, proton transport, electron transport) indicating energy production within mitochondria. Additional terms show responses to hypoxia and nitric oxide, erythropoietin signaling, and neuronal development processes (axonogenesis/axon extension), suggesting a neuronal context where mitochondrial activity supports axon growth and neuroprotection.","confidence":"High","size":24,"edges":123,"triangles":282,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":8},{"id":"GO:0071456","count":7},{"id":"GO:1902600","count":7},{"id":"GO:0036018","count":6},{"id":"GO:0043524","count":6}]},{"hash":"2228445386876718349","title":"Nervous system development and axon guidance","description":"This cluster is dominated by neural-focused terms: nervous system development, axon guidance (including semaphorin-plexin signaling, branchiomotor neuron guidance, and trigeminal nerve organization) and positive regulation of synapse assembly, suggesting a coherent theme of neural development and connectivity. Some adhesion and signaling terms are present, but the strongest signal is neural patterning and networking.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":13},{"id":"GO:0043931","count":12},{"id":"GO:0051965","count":11},{"id":"GO:0006958","count":11},{"id":"GO:0000187","count":10}]},{"hash":"2152263248012717484","title":"Developmental signaling and tissue morphogenesis","description":"The top GO terms point to developmental growth, signaling pathways (notably Wnt), tissue remodeling and ECM dynamics (angiogenesis, ECM disassembly, amelogenesis), and specific developmental contexts (midbrain development), suggesting a coherent theme of developmental signaling driving morphogenesis; a few terms like defense response may be background noise.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0050830","count":9},{"id":"GO:0035264","count":9},{"id":"GO:0030901","count":9},{"id":"GO:0001878","count":8}]},{"hash":"1960710796107340523","title":"Cardiac calcium signaling and conduction","description":"The top terms cluster around calcium release from the sarcoplasmic reticulum, regulation of calcium channels and store-operated entry, and regulation of cardiac muscle membrane potential and electrical coupling in cardiac conduction, indicating a theme of cardiac calcium handling and excitation-contraction coupling. Some craniofacial terms may reflect broader developmental roles or annotation noise.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":4},{"id":"GO:0060021","count":4},{"id":"GO:0014808","count":3},{"id":"GO:1901846","count":3},{"id":"GO:0010880","count":3}]},{"hash":"314817393679541344","title":"Cytoskeletal dynamics in cell division and migration","description":"The GO terms cluster around actin filament organization, filopodium assembly, and cell migration, with links to mitotic division and intracellular transport (e.g., organelle inheritance and pigment granule transport). This points to cytoskeletal regulation driving division, polarity, and movement as the core theme.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045769","count":2},{"id":"GO:0009826","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0031585","count":2},{"id":"GO:0051904","count":2}]},{"hash":"1418542174107366827","title":"ECM Remodeling and PKC Signaling","description":"The cluster shows strong signals for extracellular matrix disassembly and protein kinase C signaling, with supporting mentions of GTPase regulation, lipid localization, and podocyte development. This points to a module centered on ECM\u2013cytoskeletal dynamics and PKC-driven signaling that influences cell shape, adhesion, and specialized kidney cell (podocyte) function.","confidence":"Medium","size":24,"edges":100,"triangles":267,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0010918","count":5},{"id":"GO:0000001","count":5}]},{"hash":"1442686087138008541","title":"Growth factor\u2013driven immune signaling and calcium flux","description":"The top GO terms show responses to growth factors like TGF-\u03b2 and M-CSF, regulation of calcium signaling and calcium release, STAT phosphorylation, and neutrophil chemotaxis, all pointing to a signaling network that coordinates immune cell recruitment and calcium-dependent signaling, with some developmental cues (retinoic acid response and mammary gland branching). This cohesive theme justifies labeling the cluster as growth factor\u2013driven immune signaling with calcium flux.","confidence":"Medium","size":24,"edges":133,"triangles":258,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071560","count":19},{"id":"GO:0036006","count":19},{"id":"GO:0051281","count":19},{"id":"GO:0060444","count":19},{"id":"GO:0042531","count":19}]},{"hash":"1566475714733601961","title":"Neural development and gene expression control","description":"Proteins in this cluster tie neural development signals (brain development, neural tube closure) with core gene expression machinery (DNA-templated transcription, translational elongation and fidelity) and basic cellular processes (mitotic cell cycle, protein oligomerization, cytoskeletal regulation). The combination suggests a theme focused on neural development supported by gene expression and protein synthesis, with some cytoskeletal remodeling involved.","confidence":"Medium","size":24,"edges":159,"triangles":469,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071479","count":3},{"id":"GO:1990145","count":3},{"id":"GO:0006414","count":3},{"id":"GO:0032232","count":3},{"id":"GO:0006351","count":3}]},{"hash":"49642383372213603","title":"Developmental and Immune Signaling","description":"The top GO terms span developmental processes (heart, placenta, vagina development) together with signaling pathways in metabolism and immunity (insulin signaling, platelet activation, Rho signaling, TLR9 signaling, LPS response, and NF-kappaB regulation). This suggests a cluster of proteins involved in broad signaling networks that coordinate development, metabolism, and innate immune responses.","confidence":"Medium","size":24,"edges":15,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":11},{"id":"GO:0001893","count":9},{"id":"GO:2001275","count":9},{"id":"GO:0071222","count":8},{"id":"GO:0034162","count":7}]},{"hash":"1185780259341801568","title":"Glomerular ECM and basement membrane development","description":"The top terms cluster around collagen biosynthesis/organization and glomerular basement membrane development, with associated podocyte development and VEGF signaling modulation, pointing to extracellular matrix remodeling in the kidney glomerulus. While some terms touch on pregnancy, dexamethasone response, and antiviral defense, the dominant signal is renal ECM/BM formation and vascular remodeling. This makes the label representative of the main functional theme of the cluster.","confidence":"High","size":24,"edges":154,"triangles":394,"max_degree":21,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0032964","count":4},{"id":"GO:0030948","count":4},{"id":"GO:0071549","count":3}]},{"hash":"1874659305928569282","title":"Mitotic spindle and kinetochore regulation","description":"This cluster centers on mitosis-associated processes: localization of proteins to kinetochores, chromosome passenger complex targeting to the spindle midzone, and regulation of the cell cycle and CDK activity, plus related phosphatase activity. Although immune signaling terms appear, the dominant pattern is mitotic spindle organization and chromosome segregation control.","confidence":"High","size":24,"edges":243,"triangles":1453,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":24},{"id":"GO:0045736","count":24},{"id":"GO:0039502","count":15},{"id":"GO:0039563","count":15},{"id":"GO:0050860","count":15}]},{"hash":"2126918186907108824","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":20},{"id":"GO:0042254","count":9},{"id":"GO:0000462","count":6},{"id":"GO:0031120","count":5},{"id":"GO:0031118","count":5}]},{"hash":"60135587911409530","title":"Mitotic entry and chromosome condensation","description":"Based on the top GO terms, this cluster centers on mitosis and cell cycle control, including G1/S and G2/M transitions, spindle pole separation, and entry into mitosis, as well as chromatin dynamics like histone H3-S10 phosphorylation linked to chromosome condensation. A growth signaling context (insulin signaling, epithelial proliferation) is present but secondary to the core mitotic progression theme.","confidence":"High","size":24,"edges":6,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031532","count":20},{"id":"GO:0010696","count":20},{"id":"GO:0000320","count":20},{"id":"GO:0006351","count":20},{"id":"GO:2000775","count":20}]},{"hash":"1785492770199807141","title":"ERAD and Ubiquitin-Proteasome Proteostasis","description":"The top terms point to ubiquitin-dependent ERAD, deubiquitination, and proteasome regulation, with supporting hints from protein modification (sumoylation) and unfolded protein handling in the ER. This cluster likely contains proteins involved in tagging, processing, and degrading misfolded or surplus proteins via the ubiquitin-proteasome system and ERAD, i.e., proteostasis management.","confidence":"High","size":24,"edges":267,"triangles":1840,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":11},{"id":"GO:0016579","count":8},{"id":"GO:0000028","count":8},{"id":"GO:0016925","count":8},{"id":"GO:0051572","count":8}]},{"hash":"1643486250193517705","title":"Ubiquitin-Mediated Proteolysis in Mitosis","description":"The cluster is strongly enriched for ubiquitin-dependent proteolysis (SCF, K11-linked ubiquitination, autoubiquitination, ERAD) and cell cycle regulation (G2/M transition, mitosis, APC/C- and SCF-driven catabolic processes, cell division), suggesting a cohesive role in targeted protein degradation to control mitosis; some viral process and DNA repair terms may be linked as secondary associations.","confidence":"High","size":24,"edges":261,"triangles":1718,"max_degree":23,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031146","count":18},{"id":"GO:0070979","count":17},{"id":"GO:0000086","count":16},{"id":"GO:0016032","count":16},{"id":"GO:0070911","count":16}]},{"hash":"1212157258605597825","title":"Motor neuron axon guidance and neural development","description":"The top GO terms indicate strong enrichment for nervous system development and axon navigation, including lateral motor column neuron migration, peripheral nervous system neuron axonogenesis, motor neuron axon guidance, and cell-matrix adhesion, which together point to growth-cone\u2013mediated axon pathfinding and ECM interactions. Additional terms related to actin cytoskeleton regulation and detection of muscle stretch further support a motor neuron wiring context. A couple of terms (platelet aggregation, female gonad development) appear less central and may reflect pleiotropy, but the dominant signal is neural development and axon guidance.","confidence":"High","size":24,"edges":240,"triangles":1404,"max_degree":23,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070527","count":18},{"id":"GO:0097477","count":18},{"id":"GO:0048936","count":17},{"id":"GO:0007160","count":17},{"id":"GO:0008045","count":17}]},{"hash":"1336485126468847889","title":"Spinal Cord Motor Neuron Development","description":"The top GO terms are dominated by neural differentiation and motor neuron specification in the spinal cord and brainstem (visceral motor neuron differentiation, medial motor column neuron differentiation, ventral spinal cord interneuron specification, facial nucleus development, Purkinje/granule signaling), with ectoderm formation and nephric duct elongation reflecting broader embryonic development. Overall, the cluster points to neural development focusing on motor neuron generation and spinal cord patterning, making this a specific, coherent label.","confidence":"Medium","size":24,"edges":11,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":7},{"id":"GO:0021524","count":7},{"id":"GO:0035849","count":7},{"id":"GO:0001705","count":7},{"id":"GO:0021526","count":7}]},{"hash":"1226339075079556353","title":"Steroid Hormone Biosynthesis and Gonadal Development","description":"The top GO terms are dominated by steroid hormone biosynthesis (androgen, testosterone, progesterone) and female gonad development, with omega-hydroxylase P450 pathway also involved in steroid metabolism. This suggests the proteins cluster around hormone production and gonadal function, with a few other terms reflecting broader stress or vascular processes as secondary signals.","confidence":"High","size":24,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":21},{"id":"GO:0061370","count":21},{"id":"GO:0001516","count":20},{"id":"GO:0097267","count":19},{"id":"GO:0033076","count":19}]},{"hash":"1572838092224894149","title":"Pain and Temperature Sensory with Dopaminergic Signaling","description":"This cluster is dominated by GO terms related to sensory processing (pain, temperature, visual perception) and dopaminergic synaptic transmission, plus behavioral responses to cocaine, which together point to neural/SNS processing and dopamine-mediated signaling. Some terms involve signaling cascades (ERK, GTPase) and inflammatory stimuli (LPS, prostaglandin), which may reflect broader cellular responsiveness but do not outweigh the core neural-sensory theme. Confidence: Medium","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0007601","count":7},{"id":"GO:0070374","count":7}]},{"hash":"850532708528284698","title":"Steroid Hormone Metabolism","description":"The proteins are strongly linked to steroid-related pathways: androgen and progesterone metabolism and aldosterone biosynthesis, along with prostaglandin biosynthesis and omega-hydroxylase P450 activity. This points to CYP-mediated lipid/hormone metabolism as the core function, with ancillary links to reproductive and vascular biology (e.g., female gonad development and endothelial adhesion). ","confidence":"High","size":24,"edges":86,"triangles":110,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":21},{"id":"GO:0097267","count":21},{"id":"GO:0033076","count":21},{"id":"GO:0008585","count":21},{"id":"GO:0035902","count":21}]},{"hash":"831883739006471300","title":"Ubiquitin-Driven Protein Turnover and TNF/JNK Signaling","description":"The cluster is dominated by ubiquitin-related processes: ubiquitin-dependent proteolysis, autoubiquitination, and specific ubiquitin linkages (K6, K48), plus ERAD and histone catabolic activity. Additionally, links to TNF- and JNK-signaling regulation suggest these proteins modulate inflammatory/stress signaling through ubiquitin-mediated proteostasis, indicating a cohesive theme of ubiquitin-driven protein degradation with signaling implications.","confidence":"High","size":24,"edges":2,"triangles":0,"max_degree":2,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0051865","count":14},{"id":"GO:0085020","count":12},{"id":"GO:0070936","count":12},{"id":"GO:1903265","count":11}]},{"hash":"2134291321428938208","title":"Stress-Responsive Apoptosis Regulation","description":"The top GO terms cluster around regulation of apoptotic signaling in response to cellular stress, including ER stress\u2013induced intrinsic apoptosis, regulation of mitochondrial depolarization, and oxidative stress\u2013driven neuronal apoptosis, with additional terms touching on general cellular stress responses and immune development. This suggests the proteins function together in stress-related control of cell death, with some peripheral links to immune processes.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":4},{"id":"GO:0051902","count":3},{"id":"GO:1902042","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0035234","count":3}]},{"hash":"1266617590558264297","title":"Inner ear development and auditory signaling","description":"The top GO terms include sensory perception of sound and labyrinthine layer blood vessel development, which point to inner ear structure and auditory function as a core theme. While other terms (Rho signaling, thrombin receptor signaling, insulin signaling, glucose transport, immune-related terms) are more general or tissue-wide, the strong auditory-related signals provide the best cohesive theme for this cluster. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0070493","count":4},{"id":"GO:0007605","count":4},{"id":"GO:0060716","count":4},{"id":"GO:0008286","count":4}]},{"hash":"843284124772825860","title":"Skeletal development and wound healing","description":"The terms mostly reflect embryonic skeletal morphogenesis (endochondral ossification, embryonic cranial skeleton morphogenesis, anterior lateral line development) and wound healing (fibroblast proliferation), with signaling roles such as integrin activation and receptor internalization; a few metabolic terms (biotin and antibiotic biosynthesis) appear as outliers.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048146","count":4},{"id":"GO:0042060","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0031623","count":3}]},{"hash":"2039064927139222069","title":"Brain Adrenergic-Dopaminergic Signaling","description":"These GO terms cluster around brain-specific catecholaminergic signaling: dopaminergic synaptic transmission, adrenergic receptor\u2013mediated pathways (MAPK and PLC activation), and norepinephrine/epinephrine\u2013driven vasoconstriction, with brain renin-angiotensin system involvement; one thymocyte differentiation term appears as an incidental annotation but does not define the cluster.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":23},{"id":"GO:0001963","count":23},{"id":"GO:1900453","count":23},{"id":"GO:0001994","count":23},{"id":"GO:0071883","count":23}]},{"hash":"2114765661346064246","title":"Unknown","description":"The top GO terms span very different biology (heart development, cell adhesion and signaling, immune cell homeostasis, cell-cycle regulation, muscle sarcomere organization, glycosylation, plant chlorophyll metabolism, and detoxification), with no single coherent function linking the proteins, so a representative label cannot be assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0003342","count":4},{"id":"GO:0007155","count":4},{"id":"GO:0071364","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0001782","count":4}]},{"hash":"2056913526221948816","title":"Intracellular trafficking and ribosome biogenesis","description":"This cluster shows enrichment for vesicle transport between the Golgi and endoplasmic reticulum (retrograde and ER-to-Golgi), ribosomal subunit export from the nucleus, and ribosome biogenesis, along with RNA processing (mRNA splicing). Together, these terms point to core cellular logistics and the production and handling of ribosomes and RNA, suggesting a cohesive theme of intracellular trafficking plus ribosome/RNA processing rather than immune signaling or developmental processes. Confidence: Medium","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0038095","count":3},{"id":"GO:0000055","count":3},{"id":"GO:0051301","count":2}]},{"hash":"1981509383922113025","title":"Chemosensory perception and pheromone response","description":"The cluster is dominated by GO terms for detecting chemical stimuli and pheromone response (sensory perception of chemical stimulus, response to pheromone, bitter taste), indicating a shared chemosensory function. While some terms relate to vascular development or organ morphogenesis, the prevailing signal is chemical sensing, supporting a label centered on chemosensation and pheromone signaling. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":9},{"id":"GO:0007606","count":9},{"id":"GO:0045766","count":4},{"id":"GO:0050909","count":3},{"id":"GO:0001580","count":3}]},{"hash":"1456718252109277756","title":"Coagulation and Fibrinolysis Regulation","description":"The Top Terms are dominated by coagulation and fibrinolysis-related processes (blood coagulation, fibrinolysis, negative regulation of plasminogen activation, and negative regulation of fibrinolysis), suggesting the proteins cluster around clot formation and breakdown and associated extracellular matrix remodeling. Some terms like insulin processing and deglutamylation are less central but may reflect related secretory or post-translational regulatory roles of these proteins. Overall, the cluster appears centered on coagulation/fibrinolysis regulation with possible ancillary remodeling links.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030070","count":5},{"id":"GO:0051918","count":5},{"id":"GO:0010757","count":5},{"id":"GO:0035609","count":5},{"id":"GO:0007596","count":5}]},{"hash":"923530255867540538","title":"Host immune signaling and cell interactions","description":"The terms point to signaling pathways (STAT phosphorylation, NF-kappaB), immune defense (defense against Gram-positive bacteria), and host-cell interfaces (cell adhesion, symbiont entry into host cell, mechanosensing). Developmental terms are present but the converging theme is signaling coordinating host defense, cell communication, and pathogen\u2013host interactions, justifying this label.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042511","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0007157","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0051092","count":4}]},{"hash":"1683321967940804453","title":"Ubiquitination and Cytoskeletal Regulation","description":"The top GO terms are heavily focused on ubiquitination (ubiquitin-dependent protein catabolic process, protein ubiquitination, autoubiquitination) and cytoskeletal dynamics (actin filament bundle assembly, cell migration), with supporting signals like NOD2 and NF-kappaB-related regulation. This suggests a cohesive theme around protein turnover via ubiquitination coupled with changes in the cytoskeleton and cell movement, making the label representative of the cluster\u2019s function.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0016567","count":7},{"id":"GO:0033280","count":7},{"id":"GO:0051865","count":6},{"id":"GO:0070431","count":6}]},{"hash":"1272777563306521808","title":"Cytokine Regulation and Extrinsic Apoptosis","description":"The cluster is enriched for cytokine production regulation (GM-CSF, IL-13, TNF) and immune signaling, along with extrinsic apoptotic signaling and general apoptosis, indicating a theme around inflammatory cytokine control and programmed cell death. Additional terms for stress responses (response to xenobiotic stimulus, hydrogen peroxide) are present, with some development-related terms (epidermis, eye development) that may reflect pleiotropy or annotation overlap.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032725","count":3},{"id":"GO:0030307","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0070301","count":2},{"id":"GO:2000667","count":2}]},{"hash":"969380375418271337","title":"Brain Adrenergic GPCR Signaling and Dopaminergic Transmission","description":"The top GO terms cluster around neuronal GPCR signaling, especially adrenergic pathways (MAPK-activating and PLC-activating adrenergic receptor signaling), along with dopaminergic synaptic transmission and brain-regulated blood pressure. This suggests a cohesive neuronal signaling module focused on adrenergic/dopaminergic neurotransmission and cardiovascular regulation, despite a few outlier or obsolete terms.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0035625","count":16},{"id":"GO:0002035","count":13},{"id":"GO:0001963","count":13},{"id":"GO:1900453","count":13},{"id":"GO:0001994","count":13}]},{"hash":"155237071060651517","title":"Immune signaling and cytoskeletal remodeling","description":"The cluster is characterized by strong enrichment for immune-related processes: innate immune response, B cell receptor signaling, defense against virus, and cytokine/IFN signaling (IL-2 production, type II interferon signaling). In parallel, several terms highlight actin cytoskeleton dynamics and cell polarity (actin crosslink formation, actin cortical patch localization, maintenance of cell shape), suggesting these proteins coordinate signaling with cytoskeletal rearrangements during immune activation. Although bone development and insulin receptor signaling appear among the terms, the predominant theme points to immune signaling coupled with cytoskeletal remodeling.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0050853","count":5},{"id":"GO:0060348","count":5},{"id":"GO:0008286","count":4},{"id":"GO:0051607","count":4}]},{"hash":"2128921157900657364","title":"Developmental signaling and cell cycle regulation","description":"This cluster is dominated by GO terms tied to development and cell growth, including mitotic cell cycle, multicellular organism development, skin development, and positive regulation of cell proliferation. It also shows emphasis on signaling control (GTPase activity, serine/threonine kinase activity, autophosphorylation) and stress-related response (hypoxia), with supporting post-transcriptional and assembly processes (mRNA transport, protein homooligomerization). Together these suggest a cohesive theme of developmentally coordinated signaling and cell cycle regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0051028","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0031954","count":8}]},{"hash":"936222502705697025","title":"Ubiquitination and cell cycle regulation","description":"This cluster is dominated by GO terms for protein ubiquitination and the cell cycle, with many proteins also tied to mechanotransduction, suggesting a core theme of regulated protein turnover influencing cell cycle progression in response to mechanical cues. While there are additional terms related to immune signaling and vascular processes, the strongest shared signals point to ubiquitination-driven control of cell cycle and mechanotransduction.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":11},{"id":"GO:0007049","count":11},{"id":"GO:0071260","count":11},{"id":"GO:0007205","count":11},{"id":"GO:0048549","count":11}]},{"hash":"606495486170416583","title":"Ubiquitin-dependent NF-kappaB signaling and innate immunity","description":"This cluster centers on ubiquitination-related processes (ERAD, protein autoubiquitination, regulation of deubiquitination) and NF-kappaB signaling, with associated innate immune roles and suppression of viral transcription, suggesting a coherent theme of ubiquitin-mediated regulation of immune responses.","confidence":"High","size":23,"edges":171,"triangles":682,"max_degree":22,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":15},{"id":"GO:0051092","count":15},{"id":"GO:0043123","count":15},{"id":"GO:0051865","count":14},{"id":"GO:0090086","count":14}]},{"hash":"2032610102852997912","title":"Antiviral Response and RNA Processing","description":"Reasoning: The top GO terms include response to interferon-alpha and negative regulation of viral genome replication, pointing to antiviral defense. Additional terms for translation and mRNA processing indicate regulation of gene expression, which supports antiviral responses, while terms for cell migration and filopodium assembly suggest cytoskeletal changes accompanying immune responses. Some unrelated terms may reflect broader roles of the proteins, but the core signal centers on antiviral defense and RNA metabolism.","confidence":"Medium","size":23,"edges":51,"triangles":23,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0045071","count":4},{"id":"GO:0035455","count":4},{"id":"GO:0016477","count":3},{"id":"GO:0006397","count":3}]},{"hash":"1521460190001412039","title":"DNA repair and RNA decay in development","description":"The cluster prominently features nucleic acid processing terms: nonsense-mediated decay, nucleotide-excision repair, DNA topology changes, and DNA methylation, alongside development-related terms like embryonic organ development and hair cell differentiation. This points to a cohesive theme of genome maintenance and RNA quality control active during development. The MDA-5 signaling term adds an immune-response dimension, but the dominant pattern remains DNA/RNA maintenance linked to developmental processes.","confidence":"Medium","size":23,"edges":27,"triangles":18,"max_degree":8,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":14},{"id":"GO:0035315","count":13},{"id":"GO:0033683","count":13},{"id":"GO:0000717","count":13},{"id":"GO:0048568","count":13}]},{"hash":"106297263123954738","title":"Vertebrate Developmental Signaling","description":"The cluster\u2019s top GO terms cluster around vertebrate development and signaling processes, notably midbrain development, Wnt signaling, and tissue/angiogenesis-related growth. While there are some peripheral terms (e.g., digestion, coagulation), the dominant theme is developmental signaling and tissue formation in vertebrates, justifying a label centered on developmental signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":8},{"id":"GO:0030194","count":7},{"id":"GO:0031214","count":7},{"id":"GO:0035264","count":6}]},{"hash":"402581899171003034","title":"Hepatic gluconeogenesis and ketone body synthesis","description":"The cluster is enriched for gluconeogenesis, response to starvation, and ketone body biosynthesis, all core to liver energy metabolism under nutrient stress. The presence of liver development and Notch signaling terms suggests a hepatic development context, while multiple amino acid catabolic processes indicate protein-derived energy flux. These together point to hepatic energy metabolism with a developmental/ signaling component.","confidence":"High","size":23,"edges":252,"triangles":1750,"max_degree":22,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006094","count":8},{"id":"GO:0042594","count":5},{"id":"GO:0001889","count":5},{"id":"GO:0009436","count":5},{"id":"GO:0006552","count":5}]},{"hash":"2014114920667689142","title":"Osteoblast differentiation and bone development","description":"The cluster shows strong representation of bone biology terms, especially bone development and osteoblast fate commitment, indicating a primary role in osteoblast differentiation and bone formation. The accompanying membrane/cytoskeleton terms (podosome assembly, membrane tubulation, positive regulation of GTPase activity) suggest dynamic cell shape and adhesion changes typical of osteogenic cells.","confidence":"Medium","size":23,"edges":36,"triangles":0,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060348","count":8},{"id":"GO:0043547","count":6},{"id":"GO:0097320","count":6},{"id":"GO:0051044","count":6},{"id":"GO:0002051","count":6}]},{"hash":"1577923027251484547","title":"Signaling and Ion Transport","description":"The cluster includes multiple signaling pathways (integrin signaling, STAT tyrosine phosphorylation, and IL-2/IL-5/IL-7 cascades) along with ion transport and membrane excitability terms (K+ and Na+ transport, membrane depolarization, excitatory postsynaptic potential), indicating a mix of signal transduction and membrane dynamics proteins.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001046","count":5},{"id":"GO:0042511","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0035725","count":4}]},{"hash":"618243428650114786","title":"Mechanotransduction and growth signaling","description":"The highest-frequency GO term is cellular response to mechanical stimulus, suggesting mechanosensing as a core theme. Several other terms point to signaling and regulatory processes connected to growth, immune signaling, and genome maintenance, including protein ubiquitination, telomere maintenance via telomerase, NOD2 signaling, IL-12 regulation, nociception, and cell growth. While the terms span varied pathways, they collectively reflect a cluster enriched in stress-responsive signaling and growth-related processes, anchored by mechanotransduction.","confidence":"Medium","size":23,"edges":22,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":19},{"id":"GO:0000083","count":19},{"id":"GO:2001275","count":19},{"id":"GO:0016567","count":19},{"id":"GO:0032212","count":18}]},{"hash":"2000439933295932860","title":"Neuronal development and synaptic signaling","description":"The cluster shows strong representation of neural development and synaptic function terms, including hippocampus development, dendrite morphogenesis, excitatory postsynaptic potential, axon extension, calcium-dependent exocytosis, and dopamine response, suggesting proteins involved in neuronal differentiation and synaptic transmission. Some cell-cycle-related terms (mitotic cell cycle, DNA replication) appear as well, which may reflect shared domains or multifunctional proteins, but the dominant pattern is neural development and synaptic activity.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0006260","count":18},{"id":"GO:0045773","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0033138","count":16}]},{"hash":"1995535517958390777","title":"Mitotic cell cycle and chromosome segregation","description":"The top GO terms are dominated by cell cycle and chromosome dynamics: G1/S transition, meiotic/meiosis-related cell cycles, centromeric cohesin, kinetochore localization, and mitotic checkpoint signaling. These point to a core function in mitosis/meiotic progression and chromosome segregation. Terms like apoptotic process, angiogenesis, and LPS response appear as ancillary stress or signaling connections but do not define the primary theme of the cluster. ","confidence":"Medium","size":23,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016477","count":6},{"id":"GO:0071222","count":5},{"id":"GO:0000082","count":5},{"id":"GO:0051754","count":4},{"id":"GO:0034501","count":4}]},{"hash":"1814520468648604206","title":"Cell growth, autophagy, and proteostasis","description":"This cluster centers on core processes that govern cell growth and maintenance: cell cycle, transcription regulation, translation, and ubiquitination, along with regulation of autophagy and apoptosis. The presence of actin remodeling factors suggests cytoskeletal dynamics linked to these processes, and mitochondrial inheritance ties into organelle distribution during growth and division. Overall, the terms point to a cohesive module around proteostasis and cellular stress responses that coordinate growth, protein turnover, and survival.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0031663","count":2},{"id":"GO:0006355","count":2}]},{"hash":"900670836075151030","title":"Post-transcriptional RNA Processing and Translation Control","description":"The cluster\u2019s top GO terms center on mRNA processing and regulation: splicing and spliceosome activity, mRNA export and stabilization, and poly(A) tail regulation, alongside translation initiation/ reinitiation and RNA silencing by ncRNA/miRNA. This points to a cohesive role in post-transcriptional gene expression control, balancing RNA maturation with translational repression mechanisms.","confidence":"High","size":23,"edges":5,"triangles":2,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":10},{"id":"GO:0001731","count":10},{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0045292","count":9}]},{"hash":"113621430482415755","title":"Neuronal development and actin remodeling","description":"These proteins cluster around neural development and cytoskeletal regulation: GO terms emphasize neuron projection development, neural tube closure, and olfactory nerve organization, pointing to roles in neural morphogenesis. The prominent actin cytoskeleton terms (Arp2/3-mediated actin nucleation, actin filament depolymerization, GTPase activity regulation) suggest coordinated remodeling of the cytoskeleton, which is essential for neuron outgrowth and connectivity. Ubiquitination may reflect regulation of signaling components during development. Together, these terms indicate a group involved in shaping neural structures via actin dynamics and signaling.","confidence":"High","size":23,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0031175","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0000209","count":3},{"id":"GO:2000601","count":3}]},{"hash":"1825980367292599909","title":"Neural development and synaptic plasticity","description":"Most terms describe neuronal differentiation and function: long-term potentiation, excitatory postsynaptic potential, axonogenesis, memory (short and long term), calcium ion transport, and actin crosslink formation, which underlie synaptic plasticity and neural development. EMT and heart development appear as broader developmental processes but do not define this cluster; the neural signals dominate, suggesting the proteins co-function in neural development and synaptic signaling.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001837","count":7},{"id":"GO:0060291","count":7},{"id":"GO:0000278","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0051764","count":6}]},{"hash":"1070100516525387281","title":"Mitochondrial Translation and Respiratory Assembly","description":"The top GO terms are dominated by mitochondrial translation, mitochondrial electron transport, and mitochondrial respiratory chain complex II assembly, indicating a mitochondria-centered program of protein synthesis and respiratory complex assembly. While there are also general translation and chromatin/transcription terms, the strongest signal ties to mitochondrial translation and respiration. ","confidence":"High","size":23,"edges":235,"triangles":1546,"max_degree":22,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0034396","count":3},{"id":"GO:0034724","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0035551","count":3}]},{"hash":"207047252916852738","title":"Embryonic development and morphogenesis","description":"The top GO terms point to diverse embryonic tissue development and patterning (pancreatic development, mesoderm formation, placenta/trophoblast differentiation, left-right patterning, palate development, hair follicle morphogenesis), indicating a cohesive theme of embryo development and tissue morphogenesis; a couple of terms like splicing are peripheral rather than conflicting.","confidence":"High","size":23,"edges":10,"triangles":1,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003323","count":7},{"id":"GO:0032298","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0060972","count":6},{"id":"GO:0007498","count":6}]},{"hash":"2020742869537222355","title":"Retrotransposons and Proviral Integration","description":"The top GO terms cluster around reverse transcription and transposition (RNA-templated DNA biosynthesis, DNA transposition, retrotransposition) plus proviral latency and viral entry, suggesting activity of mobile genetic elements and integrated viral genomes. Some terms imply virus\u2013host interactions and apoptosis activation by symbionts, reinforcing a theme of viral/mobile element life cycles rather than a single cellular pathway.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0090502","count":6},{"id":"GO:0006278","count":6},{"id":"GO:0075732","count":6},{"id":"GO:0006310","count":6},{"id":"GO:0039651","count":6}]},{"hash":"499121211954794420","title":"Neuronal signaling and synaptic plasticity","description":"The cluster is enriched for neural-related processes: GABA signaling, excitatory postsynaptic potentials, long-term synaptic plasticity regulation, receptor internalization, and cellular responses to electrical stimuli. It also includes ion transport and sensory visual perception terms, which together point to synaptic transmission and plasticity across neural circuits involved in behavior and sensory processing (e.g., locomotion, conditioned taste aversion). This makes a cohesive label focusing on neuronal signaling and plasticity.","confidence":"High","size":23,"edges":221,"triangles":1241,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":22},{"id":"GO:0071805","count":22},{"id":"GO:0007626","count":22},{"id":"GO:0060079","count":22},{"id":"GO:0007214","count":22}]},{"hash":"1380892175033530420","title":"Cholesterol and Lipid Transport Regulation","description":"The top GO terms cluster around cholesterol transport and lipoprotein clearance (cholesterol/phospholipid efflux, chylomicron/remnant clearance, and negative regulation of lipoprotein uptake), indicating a unifying theme of lipid homeostasis and trafficking; additional terms on endocytosis and signaling likely reflect related regulatory layers.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902436","count":6},{"id":"GO:0045925","count":6},{"id":"GO:0046069","count":6},{"id":"GO:0034382","count":2},{"id":"GO:0032375","count":2}]},{"hash":"1525827279693483901","title":"B cell signaling and lymphocyte development","description":"The most frequent GO terms describe B cell receptor signaling, B cell affinity maturation, IL-4 production, NK T cell differentiation, and hematopoiesis, indicating a lymphocyte-focused immune cluster. A couple of terms refer to insulin/PI3K regulation but are labeled obsolete and likely noise. Overall, this cluster maps to immune activation and development, particularly B cell\u2013mediated signaling and blood cell formation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0050853","count":5},{"id":"GO:0001865","count":5},{"id":"GO:0032633","count":5}]},{"hash":"877803463169348255","title":"Neuronal signaling and brain development","description":"This cluster is dominated by GO terms tied to neural function: phosphatidylinositol-mediated signaling, regulation of synaptic vesicle exocytosis, dopamine secretion, nervous system development, and brain development. While a few terms relate to ribophagy or immune defense, the core signal is coordinated neuronal signaling and brain growth. Confidence reflects a strong, representative theme despite a few outliers.","confidence":"High","size":23,"edges":223,"triangles":1242,"max_degree":22,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048015","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0031384","count":6},{"id":"GO:2000300","count":6},{"id":"GO:0007399","count":6}]},{"hash":"189201158267138886","title":"Innate immune signaling and inflammation","description":"The proteins cluster around innate immune recognition and inflammatory signaling, with emphasis on dsRNA and lipoteichoic acid responses, NF-kappaB and JNK pathway regulation, nitric oxide production, and cytokine/IL-1\u03b2 production, all aligning with defense against Gram-positive bacteria and viral components.","confidence":"High","size":23,"edges":19,"triangles":2,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045429","count":10},{"id":"GO:0051092","count":9},{"id":"GO:0043330","count":8},{"id":"GO:0071223","count":8},{"id":"GO:0046330","count":8}]},{"hash":"1829417199684366167","title":"Nervous system development and MAPK signaling","description":"This cluster centers on neural development (nervous system development; regulation of neuron survival) and signaling pathways, notably the ERK1/ERK2 cascade (MAPK signaling). It also notes GTPase activity regulation, which underpins cytoskeletal dynamics relevant to neurons and development, plus responses to mechanical stimuli and ion transport linked to neuronal function. While there are also terms touching angiogenesis and muscle/hair follicle development, the dominant themes converge on nervous system development and MAPK-driven signaling. ","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0010765","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0001525","count":3}]},{"hash":"889924957280698477","title":"Unknown","description":"The top GO terms cover a broad mix across signaling regulation (GTPase activity, NF-kappaB), muscle physiology, development, chromatin organization, and innate immunity. There isn\u2019t a single unifying function that ties these proteins together in this cluster, so a specific label isn\u2019t clearly representative.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0043123","count":3},{"id":"GO:0035994","count":3},{"id":"GO:0010881","count":3},{"id":"GO:0006348","count":3}]},{"hash":"1927631502291591721","title":"Neuronal vesicle trafficking and cytoskeleton remodeling","description":"The cluster's top GO terms center on exocytosis and endocytosis (calcium-regulated exocytosis, endocytosis, neurotransmitter receptor transport), plus cell polarity and actin cytoskeleton remodeling (cell polarity establishment, actin reorganization) and neural development. This combination strongly suggests processes involved in synaptic vesicle cycling and cytoskeletal dynamics in neurons, despite a few outlier terms. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0031532","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0045956","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0043547","count":4}]},{"hash":"629823037210265779","title":"H2S biosynthesis and transsulfuration","description":"The cluster is enriched for hydrogen sulfide biosynthetic process, transsulfuration, and homocysteine and cysteine metabolism, pointing to sulfur amino acid metabolism as the core theme. Additional GO terms for fatty acid and carbohydrate metabolism suggest a broader metabolic context, while activation of protein kinase activity hints at regulatory signaling. Overall, the common thread is sulfur metabolism and H2S production.","confidence":"High","size":23,"edges":118,"triangles":321,"max_degree":21,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070814","count":9},{"id":"GO:0055114","count":9},{"id":"GO:0043418","count":9},{"id":"GO:0019346","count":9},{"id":"GO:0006535","count":9}]},{"hash":"243329969956272345","title":"Neuronal synaptic plasticity and signaling","description":"The top GO terms converge on synaptic modulation and signaling in neurons\u2014long-term synaptic depression, regulation of long-term plasticity, intracellular signal transduction, receptor internalization, and electrical stimulus responses\u2014along with neural development (cerebellar granule cells) and related behaviors. This suggests a cluster of proteins involved in adjusting synaptic strength and neural circuit signaling, with supporting roles in development and behavior. ","confidence":"High","size":23,"edges":44,"triangles":40,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0060292","count":10},{"id":"GO:0035556","count":7},{"id":"GO:0001967","count":7},{"id":"GO:0021707","count":7},{"id":"GO:0007274","count":6}]},{"hash":"1937670825778228360","title":"Unknown","description":"The GO terms span neural and reproductive development, transcription initiation, and metabolic signaling, with no single cohesive function linking them. This mix suggests the proteins do not share a common, interpretable pathway or process, making a precise, single-label theme unlikely. ","confidence":"","size":23,"edges":49,"triangles":33,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0008286","count":5},{"id":"GO:0035948","count":5},{"id":"GO:0006367","count":4},{"id":"GO:0022037","count":4},{"id":"GO:0061038","count":4}]},{"hash":"1121817962895065246","title":"CNS Adrenergic and Dopaminergic Signaling","description":"The cluster is dominated by terms tied to brain adrenergic signaling and dopaminergic synaptic transmission, including MAPK-activating and PLC-activating adrenergic pathways, brain renin-angiotensin involvement, and norepinephrine/epinephrine\u2013driven vasoconstriction that modulates systemic blood pressure. Together these indicate a cohesive theme of central neuromodulatory signaling with vascular regulation, with a few outliers referencing immune processes but not defining the cluster.","confidence":"High","size":23,"edges":101,"triangles":120,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"1137696656769212688","title":"Neuronal signaling and cytoskeletal dynamics","description":"This cluster combines neural-related terms (adult locomotory behavior, myelination in peripheral nervous system, cellular response to retinoic acid) with cytoskeletal regulation (regulation of Rho signaling, actin cortical patch assembly, TORC2 signaling), suggesting a module focused on neuronal signaling and cytoskeletal remodeling important for neural development and function. Some terms are obsolete or peripheral, but the core theme centers on nervous system processes and cytoskeletal dynamics.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035066","count":2},{"id":"GO:0001878","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0035023","count":2}]},{"hash":"945140138302865568","title":"ER stress-driven transcription in development and immunity","description":"The top GO terms center on PERK-mediated unfolded protein response and transcription by RNA polymerase II, signaling ER stress\u2013driven transcription. Coupled terms like macrophage differentiation and IL-4 response point to immune signaling, while pituitary development, brain segmentation, and rhombomere development indicate developmental processes. Together they suggest a cohesive theme of ER stress\u2013induced transcriptional regulation across development and immune contexts.","confidence":"High","size":23,"edges":249,"triangles":1691,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0036499","count":10},{"id":"GO:0030225","count":9},{"id":"GO:1990440","count":9},{"id":"GO:0021983","count":9}]},{"hash":"752480756454867338","title":"Cell-Cell Adhesion and Neural Development","description":"The strongest signal in this cluster is cell-cell adhesion (both heterophilic and homophilic), with related terms for nervous system development, synapse assembly, and specialized adhesion in cardiac conduction, suggesting a group of adhesion molecules guiding neural connectivity and tissue communication. Immune regulation and bone ossification appear as additional associations but are less central than adhesion and neural development.","confidence":"High","size":23,"edges":167,"triangles":495,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0007156","count":12},{"id":"GO:0043931","count":10},{"id":"GO:0002859","count":10},{"id":"GO:0086072","count":10}]},{"hash":"2116454722699393861","title":"Skin and vascular development via PI3K-AKT signaling","description":"The cluster is dominated by terms tied to skin/epidermal differentiation (keratinocyte differentiation), skeletal development, fibroblast proliferation, and blood vessel lumenization, all connected by PI3K/AKT signaling. A few other terms (immune response to muramyl dipeptide, receptor clustering) appear less central but do not override the main developmental/angiogenic theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":5},{"id":"GO:0030216","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0048146","count":5},{"id":"GO:0051965","count":5}]},{"hash":"1746642044808008393","title":"Embryonic Development and Tissue Morphogenesis","description":"The top GO terms cluster around embryogenesis, patterning, placental development, EMT, and tissue morphogenesis (cartilage formation, pancreatic development), indicating a group of proteins tied to early development and lineage differentiation rather than a single pathway.","confidence":"Medium","size":23,"edges":27,"triangles":0,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":18},{"id":"GO:0060972","count":18},{"id":"GO:0060806","count":18},{"id":"GO:0035270","count":18},{"id":"GO:0060707","count":18}]},{"hash":"1477862750261724519","title":"Dopaminergic signaling and sensory perception","description":"The cluster is dominated by terms tied to dopaminergic synaptic transmission, cocaine-related behavioral responses, and various sensory processes (visual perception/learning, pain perception). Coupled with signaling pathway terms (ERK1/2 cascade regulation, GTPase activity) this points to neuronal signaling and plasticity underlying reward, perception, and behavior. A few terms (heart development, macrophage chemotaxis) may reflect pleiotropy or shared signaling components, but the core theme remains neural signaling and sensory processing.","confidence":"High","size":23,"edges":192,"triangles":757,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":15},{"id":"GO:0007507","count":15},{"id":"GO:0007601","count":15},{"id":"GO:0048148","count":15},{"id":"GO:0043547","count":15}]},{"hash":"1070991422134261826","title":"Unknown","description":"The top GO terms span bacterial biofilm formation, vertebrate development (angiogenesis and cardiac neural crest\u2013derived heart development), innate immune responses (dsRNA and muramyl dipeptide), and general signaling processes (MAPKK activation, spindle assembly, histone phosphorylation). These diverse contexts do not reveal a single coherent function linking all proteins, so a precise label cannot be assigned.","confidence":"","size":23,"edges":20,"triangles":5,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":22},{"id":"GO:0090606","count":22},{"id":"GO:0000186","count":22},{"id":"GO:0061308","count":22},{"id":"GO:0001525","count":22}]},{"hash":"1927869464690173080","title":"GTPase-regulated ER-Golgi trafficking and ribosome biogenesis","description":"The top terms cluster around regulated GTPase activity, TORC1 signaling, ER-Golgi vesicle transport, mRNA transport, and ribosome biogenesis-related processes (mitotic cell cycle and rRNA processing). This pattern suggests a cohesive role in coordinating growth-related signaling, vesicle trafficking, and ribosome production during cell division. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0051301","count":6},{"id":"GO:0038202","count":6},{"id":"GO:0070262","count":6},{"id":"GO:0051028","count":6}]},{"hash":"1401710506980526926","title":"Nucleolar ribosome biogenesis","description":"Top terms center on ribosome biogenesis and nuclear export, notably ribosomal small subunit biogenesis and large subunit export, along with RNA processing activities like tRNA modification. While cell cycle and cohesion terms appear, the prevailing signal is ribosome production in the nucleolus, making this the most representative label for the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0042274","count":4},{"id":"GO:1990022","count":3},{"id":"GO:0007064","count":3},{"id":"GO:0034087","count":3},{"id":"GO:0044376","count":3}]},{"hash":"1659846624833021780","title":"Unknown","description":"These proteins are associated with a wide range of processes, including transcription regulation, immune defense, signaling, and various developmental and tissue-remodeling events, with no single dominant function across the cluster. Because the GO terms point to disparate biological contexts rather than a unifying theme, there isn't a reliable concise label.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0050830","count":7},{"id":"GO:0001878","count":7},{"id":"GO:0006958","count":7},{"id":"GO:0016055","count":7}]},{"hash":"807578778848824576","title":"Complement activation and coagulation factors","description":"This cluster shows strong enrichment for complement activation (lectin and classical pathways) and blood coagulation, indicating a group of proteins involved in innate immune defense and hemostasis. While other terms like collagen catabolic process, Wnt signaling, and growth-related terms appear, the dominant theme is immune/coagulation.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":10},{"id":"GO:0030574","count":10},{"id":"GO:0007596","count":10},{"id":"GO:0006958","count":10},{"id":"GO:0016055","count":9}]},{"hash":"1897721111292546010","title":"Midbrain development and transcriptional regulation","description":"Most representative GO terms point to transcriptional regulation by RNA polymerase II (both positive and negative) and midbrain development, suggesting a neural development program governed at the transcriptional level. Other terms (biomineral/tissue development, digestion, endothelial barrier) are less central and may reflect broader annotations, but do not override the main theme. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0030194","count":4},{"id":"GO:0031214","count":4}]},{"hash":"1011111137794771528","title":"Endothelial signaling and remodeling","description":"The cluster\u2019s top GO terms emphasize ephrin receptor signaling, endothelial cell delamination, and actin filament bundle assembly, which together point to vascular signaling and cytoskeletal remodeling during endothelial morphogenesis and angiogenesis. While other terms (like adipogenesis or immune signaling) are present, the vascular remodeling theme best integrates the core functions observed.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045444","count":4},{"id":"GO:1902953","count":4},{"id":"GO:0048013","count":4},{"id":"GO:0051017","count":4},{"id":"GO:0032212","count":3}]},{"hash":"335126795036752328","title":"Brain Adrenergic and Dopaminergic Signaling","description":"Based on the GO terms, the cluster centers on neural signaling in the brain, especially dopaminergic synaptic transmission and adrenergic receptor\u2013mediated pathways (MAPK-activating, phospholipase C\u2013activating), along with related modulation of synaptic plasticity and brain-associated renin-angiotensin signaling. A single immune-related term appears but the dominant theme is neurochemical signaling in the brain, justifying this label.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":23},{"id":"GO:0001963","count":23},{"id":"GO:1900453","count":23},{"id":"GO:0001994","count":23},{"id":"GO:0071883","count":23}]},{"hash":"1354529254183151831","title":"Cell polarity and Rac GTPase regulation","description":"Based on the dominant GO terms, this cluster centers on regulation of cell polarity, Rac GTPase signaling, and related trafficking processes (endocytic recycling and cell size control). These together point to a module coordinating cell polarity with cytoskeletal and membrane trafficking dynamics. A few terms (e.g., apoptotic signaling and osteoclast differentiation) seem ancillary or context-specific noise rather than core cluster themes.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000114","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0008625","count":2},{"id":"GO:0035021","count":2}]},{"hash":"1152380499895207523","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0034316","count":9},{"id":"GO:0035264","count":9},{"id":"GO:0000398","count":8},{"id":"GO:0000480","count":8},{"id":"GO:0000447","count":8}]},{"hash":"426757752465009132","title":"Cell Polarity and Cytoskeletal Remodeling","description":"The cluster centers on terms tied to cell polarity and cytoskeletal dynamics (epithelial apical/basal polarity, microvillus assembly, Rho signaling, GTPase activation) and morphogenesis (convergent extension, cochlea morphogenesis), plus regulation by dephosphorylation. Some terms like social behavior and dendritic cell apoptotic process appear less connected and may reflect annotation noise.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006470","count":5},{"id":"GO:0035176","count":5},{"id":"GO:0019933","count":5},{"id":"GO:0030033","count":5},{"id":"GO:0045198","count":5}]},{"hash":"138698362868031232","title":"RNA processing and translational control","description":"The cluster centers on post-transcriptional RNA metabolism and regulation of gene expression, including mRNA splicing, nuclear export, stabilization, poly(A) tail regulation, and both translational initiation (including IRES-dependent initiation) and RNA silencing pathways (miRNA and regulatory ncRNA\u2013mediated silencing). This combination of GO terms points to a cohesive theme around RNA handling and control of translation. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0000002","count":3},{"id":"GO:0006376","count":2}]},{"hash":"2129858973301785651","title":"Mitochondrial import, cristae formation, and Ca2+ homeostasis","description":"This cluster is dominated by mitochondrial-focused terms: import into the intermembrane space, cristae formation, and Ca2+ homeostasis, indicating a core theme around mitochondrial structure and function. The presence of hypoxia response and NOS activity suggests mitochondrial signaling in stress and energy regulation, which can relate to cardiac stress responses like hypertrophy. Some broader terms (transcription, splicing, xenobiotic response, polysaccharide catabolism) may reflect general cellular processes but do not override the mitochondrial-centric pattern.","confidence":"High","size":22,"edges":20,"triangles":0,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045041","count":4},{"id":"GO:0051560","count":4},{"id":"GO:0042407","count":4},{"id":"GO:0051000","count":3},{"id":"GO:0071456","count":3}]},{"hash":"401587375953944280","title":"Neuromuscular development and locomotion","description":"The cluster is dominated by GO terms related to neural development and neuromuscular function, including dendrite development, synaptic assembly at neuromuscular junctions, neuromuscular control of balance, and adult locomotory behavior, with supporting signals for learning and general growth. While a couple terms (ecdysis/cuticle, vasculature development) are broader or less central, the strongest and most frequent signals point to nervous system development and movement, justifying this label.","confidence":"Medium","size":22,"edges":18,"triangles":0,"max_degree":6,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0040014","count":4},{"id":"GO:0016358","count":4},{"id":"GO:0010971","count":4},{"id":"GO:0042395","count":4},{"id":"GO:0050885","count":4}]},{"hash":"215367267484173046","title":"Cytoskeletal remodeling and EMT","description":"The top GO terms cluster around actin cytoskeleton dynamics and epithelial-to-mesenchymal transition (EMT): podosome assembly, astral microtubule organization, terminal web assembly, regulation of Rho signaling, and cellular response to TGF-beta, which is a key EMT driver. Positive regulation of nitric-oxide synthase activity can intersect with signaling pathways that influence cytoskeletal changes. Some terms like mating plug formation or intestinal glucose absorption are less related and represent background noise, but the dominant theme is cytoskeletal remodeling and EMT-associated signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0051000","count":6},{"id":"GO:1902896","count":6},{"id":"GO:0001837","count":6},{"id":"GO:0071800","count":6},{"id":"GO:0035023","count":6}]},{"hash":"787166784109410770","title":"Vision and dopaminergic signaling","description":"Most GO terms cluster around vision-related signaling (visual perception, opsin signaling, visual learning) and dopaminergic synaptic activity with ERK pathway modulation and cocaine-related behavioral responses, pointing to neural signaling in visual and reward circuits. A couple of terms like heart development and macrophage chemotaxis are broader annotations that likely reflect shared pathways rather than core theme.","confidence":"High","size":22,"edges":210,"triangles":1159,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0001963","count":16},{"id":"GO:0048148","count":16},{"id":"GO:0071380","count":16}]},{"hash":"435964171520472647","title":"Developmental and Immune Differentiation Regulators","description":"The top GO terms point to transcriptional regulation (RNA polymerase II) coupled with immune signaling (interleukin-4 response, MHC II biosynthesis, macrophage differentiation) and diverse developmental processes (ring gland, pancreas, placenta, hepatocyte proliferation). This suggests a set of proteins that modulate transcription during both development and immune cell differentiation, hence the combined developmental-immune regulator theme.","confidence":"Medium","size":22,"edges":230,"triangles":1520,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0071353","count":10},{"id":"GO:0045348","count":9},{"id":"GO:1900100","count":8},{"id":"GO:0072574","count":8}]},{"hash":"1695250504250804493","title":"Embryonic eye and neural development","description":"The cluster is enriched for eye morphogenesis and camera-type eye development terms, along with neural development signals (neuron development, axon guidance, PNS) and related embryonic processes (primitive streak formation, hypothalamus/pituitary differentiation), suggesting a coordinated role in early eye and nervous system formation.","confidence":"High","size":22,"edges":21,"triangles":1,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0090009","count":8},{"id":"GO:0048048","count":8},{"id":"GO:0043010","count":8}]},{"hash":"532899184821748116","title":"Dopaminergic and Vision-Related Neural Signaling","description":"This cluster is dominated by GO terms about neural signaling and sensory processing, including visual perception and learning, dopaminergic synaptic transmission, motor/drug-response behavior (cocaine), and ERK signaling. While metabolic and non-neural terms appear, the strongest signals point to neural signal transduction and sensory/modulatory pathways, especially involving dopamine and vision-related processes.","confidence":"Medium","size":22,"edges":38,"triangles":11,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0001963","count":16},{"id":"GO:0048148","count":16},{"id":"GO:0071380","count":16}]},{"hash":"24870742380206900","title":"Transcriptional Regulation and Cell Proliferation","description":"This cluster centers on transcriptional control (regulation of transcription by RNA polymerase II, regulation of DNA-templated transcription) and cell growth/division (cell population proliferation, mitotic cell cycle). While there are a few more divergent terms (development, metal ion response, etc.), the dominant theme ties gene expression regulation to proliferative processes.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008283","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3}]},{"hash":"1017101443097352125","title":"Cochlear development and synaptic maturation","description":"The top GO terms cluster around inner ear development (cochlea morphogenesis, sensory perception of sound), neuronal and synaptic maturation (dendrite development, receptor localization to synapse, ephrin receptor signaling), and learning-related processes, suggesting these proteins coordinately drive cochlear morphogenesis and maturation of auditory synapses, with some terms reflecting general cellular organization (Golgi localization, tight junction assembly) that support specialized ear cells.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":5},{"id":"GO:0007605","count":3},{"id":"GO:0051835","count":3},{"id":"GO:0051683","count":3},{"id":"GO:0016358","count":3}]},{"hash":"1577181395177156418","title":"Mitotic progression and ER-Golgi trafficking","description":"Top GO terms show strong enrichment for mitotic processes (mitotic cell cycle, mitotic spindle assembly, cell division, multicellular organism growth, cell population proliferation) alongside vesicle transport between the ER and Golgi (COPII-coated vesicle budding; ER\u2013Golgi and Golgi-to-ER retrograde transport). This pattern suggests a cluster of proteins that function in both cell division and the secretory pathway, coordinating mitosis with intracellular trafficking rather than a single narrow role.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035264","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0050830","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0090307","count":7}]},{"hash":"1869858843688686775","title":"mRNA processing and translation regulation","description":"Top terms show signals for translation initiation control (translation reinitiation, preinitiation complex) alongside RNA processing steps (spliceosome-mediated splicing, splice site recognition) and mRNA metabolism (export, stabilization, poly(A) tail regulation, and miRNA-mediated silencing). This convergence indicates a cohesive cluster focused on post-transcriptional gene expression regulation, from splicing to translation.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":13},{"id":"GO:0001731","count":13},{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":12},{"id":"GO:1900363","count":11}]},{"hash":"81259310772615177","title":"Multifunctional regulators of signaling and transcription","description":"The top GO terms point to regulatory roles in signaling (GTPase activity, autophosphorylation), transcription control (RNA polymerase II), and broader cellular processes (innate immune response, actin remodeling, proliferation). The terms are diverse and do not converge on a single pathway, suggesting these proteins act as general regulatory connectors across signaling and gene expression rather than a specific function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0007205","count":2}]},{"hash":"542728976089027467","title":"Cardiac calcium signaling and electrical conduction","description":"The cluster is dominated by GO terms tied to calcium handling in muscle, especially release of sequestered Ca2+ from the sarcoplasmic reticulum, regulation of Ca2+ release, activation of store-operated calcium channels, and regulation of cardiac muscle cell membrane potential, along with a term on electrical coupling in cardiac conduction. These collectively point to excitation-contraction coupling and electrical signaling in cardiac tissue, with a few developmental terms that are less central to the core theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014808","count":3},{"id":"GO:0060021","count":3},{"id":"GO:1901846","count":3},{"id":"GO:0010880","count":3},{"id":"GO:0031585","count":3}]},{"hash":"1424187578586635712","title":"Blood coagulation and fibrinolysis regulation","description":"Based on the top GO terms, the cluster is enriched for processes related to blood coagulation, fibrinolysis, plasminogen activation, and extracellular matrix (ECM) secretion/remodeling. This points to a cohesive theme around hemostasis and ECM dynamics. Some terms (e.g., regulation of GTPase activity, insulin processing, deglutamylation) may reflect broader regulatory interactions or polypeptide processing present in the cluster, but the strongest shared function appears to be coagulation and fibrinolysis.","confidence":"High","size":22,"edges":44,"triangles":25,"max_degree":19,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0001302","count":6},{"id":"GO:0043087","count":6},{"id":"GO:0030070","count":6},{"id":"GO:0051918","count":6},{"id":"GO:0010757","count":6}]},{"hash":"262139561952749288","title":"Rho GTPase-driven actin remodeling and endocytosis","description":"The top GO terms cluster around Rho GTPase signaling and actin dynamics (regulation of Rho protein signal transduction, small GTPase-mediated signal transduction, actin filament branching, filopodium assembly, and cell spreading) and vesicular trafficking (endocytosis, Golgi-to-ER transport), indicating a cohesive theme of cytoskeletal remodeling coordinated with membrane trafficking and adhesion, with a possible link to heart development.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0046847","count":6},{"id":"GO:1900026","count":6},{"id":"GO:0006897","count":6}]},{"hash":"1335515412646261550","title":"Cell cycle regulation and ubiquitination","description":"The top GO terms cluster around cell cycle, cell division, and protein ubiquitination, indicating roles in regulation of cell proliferation and ubiquitin-mediated protein turnover. While there are additional signals of immune response and hormone-related processes, the dominant theme across the terms is cell cycle control and protein turnover.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0071357","count":2},{"id":"GO:0061077","count":2}]},{"hash":"1148470703789961660","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":85,"triangles":112,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":11},{"id":"GO:0048026","count":11},{"id":"GO:0001731","count":10},{"id":"GO:0002188","count":9},{"id":"GO:0006378","count":9}]},{"hash":"2134963789541041125","title":"Dopaminergic Visual Processing and Reward Behavior","description":"The top GO terms cluster around vision and neural signaling: visual perception, visual learning, opsin-mediated signaling, and dopaminergic synaptic transmission, alongside behavioral responses to cocaine and sensory pain. This suggests the proteins co-function in visual processing alongside reward/eye-brain signaling pathways. Some terms like heart development and diet-induced thermogenesis appear as outliers or pleiotropic annotations, but do not define the core theme. ","confidence":"High","size":22,"edges":194,"triangles":940,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":17},{"id":"GO:0001963","count":16},{"id":"GO:0007507","count":16},{"id":"GO:0022400","count":16},{"id":"GO:0007601","count":16}]},{"hash":"412941945130120170","title":"Rab/Rap Signaling and Vesicle Trafficking","description":"The top GO terms point to Rab and Rap small GTPase\u2013mediated signal transduction and a suite of membrane trafficking processes, including Golgi to plasma membrane and plasma membrane to endosome transport. This suggests a cohesive theme of vesicle trafficking coupled with signaling, with a few peripheral terms (e.g., axonogenesis regulation, immune cell aggregation) reflecting broader roles in development and immune contexts.","confidence":"High","size":22,"edges":199,"triangles":1023,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0032482","count":21},{"id":"GO:0050771","count":21},{"id":"GO:0097327","count":14},{"id":"GO:0048227","count":14},{"id":"GO:0000001","count":14}]},{"hash":"1884013859864623339","title":"Developmental transcription regulation and brain development","description":"The top GO terms are centered on development (multicellular organism development, brain development, growth) and regulation of transcription, especially DNA-templated transcription. While there are additional terms related to signaling (TGF-beta), protein interactions, immune defense, and general cellular processes (translation reinitiation, chromosome segregation), the dominant theme is development with gene expression control, notably in the brain. Confidence: Medium","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0006355","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0030433","count":3}]},{"hash":"39572499886902742","title":"Neuronal Synaptic Signaling and Plasticity","description":"This cluster is dominated by terms related to synaptic function and neural signaling: GABAergic transmission, excitatory postsynaptic potential, and regulation of neurotransmitter release, along with positive regulation of the ERK/MAPK cascade, which is a key pathway for activity-dependent synaptic plasticity. The presence of mitochondrial fission aligns with the energetic and structural needs of active synapses. A term related to oligodendrocyte differentiation appears less central but may reflect broader neural development contexts or glia\u2013neuron interactions. Overall, the cluster centers on neuronal communication and plasticity mechanisms.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035641","count":5},{"id":"GO:0048714","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0051932","count":4},{"id":"GO:0033138","count":4}]},{"hash":"2119674266595830580","title":"Developmental Signaling and Immune Response","description":"The GO terms point to involvement in development (spinal cord development, transcription regulation) and broad signaling pathways (PI3K/AKT, I-kappaB phosphorylation, IL-1 signaling, LPS response) with cytoskeleton dynamics (microtubule-based movement). This combination suggests a cluster of proteins coordinating signaling with transcriptional regulation during development and immune responses, rather than a single pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:2000811","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0007018","count":3},{"id":"GO:0043491","count":3}]},{"hash":"1114648403927547887","title":"Steroid Hormone Metabolism and Gonadal Development","description":"The top GO terms point to steroid biosynthesis and gonadal function: female gonad development; androgen, progesterone, and aldosterone metabolic processes; prostaglandin biosynthesis; and omega-hydroxylase P450 pathway. These together suggest a cluster centered on steroid hormone production and gonadal development. A few terms like endothelial adhesion and stress/ion responses appear ancillary, but do not override the core steroid-related theme.","confidence":"High","size":22,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":17},{"id":"GO:0001516","count":16},{"id":"GO:0097267","count":16},{"id":"GO:0033076","count":16},{"id":"GO:0035902","count":16}]},{"hash":"413549857837630480","title":"Ubiquitin-Proteasome System and NF-\u03baB Signaling","description":"Enrichment for deubiquitination, proteasome assembly and degradation pathways (SCF-dependent and ubiquitin-dependent/independent), and non-canonical TNF/NF-\u03baB signaling, plus antigen processing/presentation via MHC I. This points to a coherent module centered on ubiquitin-proteasome\u2013driven protein turnover with immune signaling connections and stress responses.","confidence":"High","size":22,"edges":218,"triangles":1309,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":10},{"id":"GO:0046686","count":6},{"id":"GO:0033209","count":6},{"id":"GO:0010499","count":6},{"id":"GO:0006521","count":6}]},{"hash":"726752917146951303","title":"GPCR signaling and energy metabolism","description":"Top GO terms indicate strong GPCR signaling (adenylate cyclase activation) co-occurring with energy/metabolic processes (electron transport chain, diet-induced thermogenesis, temperature response), plus physiological regulation (blood pressure, saliva secretion, membrane potential). This suggests proteins function together in GPCR-driven signaling that governs energy homeostasis and related physiological outputs.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":15},{"id":"GO:0022900","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0007190","count":13},{"id":"GO:0002024","count":13}]},{"hash":"674205645127159830","title":"Mitotic and meiotic chromosome condensation and cohesion","description":"The top GO terms cluster around chromosome condensation during mitosis and meiosis, plus cohesin loading and sister chromatid cohesion, as well as DNA replication. This suggests a shared function in chromosome organization and duplication during cell division, with a few peripheral terms related to broader developmental processes or stress responses.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0070550","count":2},{"id":"GO:0007076","count":2},{"id":"GO:1903342","count":2}]},{"hash":"1199197595856676076","title":"Cytoskeletal remodeling and signaling regulation","description":"This cluster centers on signaling and cytoskeletal dynamics: GO terms for ERK cascade regulation, small GTPase signaling, actin-based structures (stress fibers, filopodia), and cell spreading suggest coordinated signaling with cytoskeletal remodeling; additional terms on ubiquitination and serine phosphorylation imply regulation of signaling components, while mitochondrial fission and synaptic transmission indicate broader cellular communication and organization. Overall, the proteins seem linked by signaling control coupled to cytoskeletal and organelle remodeling, hence this label. ","confidence":"Medium","size":22,"edges":23,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0043149","count":4},{"id":"GO:0051932","count":4},{"id":"GO:0033138","count":4}]},{"hash":"470953334197370515","title":"Developmental Morphogenesis and Innate Immunity","description":"The cluster prominently features morphogenesis terms for kidney tubules and lymphatic vessels, suggesting developmental processes, along with innate immune response and defense to virus terms, indicating immune signaling involvement. There are also terms about signaling regulation (negative regulation of protein kinase activity) and proteostasis (ERAD and chaperone activity), which can tie signaling, development, and immune responses together. Overall, the data point to a theme around signaling-modulated development with immune-defense roles.","confidence":"Medium","size":22,"edges":20,"triangles":4,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006469","count":7},{"id":"GO:0072287","count":6},{"id":"GO:0036303","count":6},{"id":"GO:0072237","count":6},{"id":"GO:0045087","count":5}]},{"hash":"2183870348493432376","title":"Steroid hormone and lipid biosynthesis","description":"The top GO terms point to steroid biosynthesis (testosterone, glucocorticoids, C21-steroid metabolism) and lipid biosynthesis (sphingolipids, PHB), suggesting a core theme of steroid and lipid biosynthetic pathways. Antibiotic-related terms and transcription regulation appear less central to this cluster. Therefore, the label reflects the predominant function of these proteins. ","confidence":"Medium","size":22,"edges":28,"triangles":2,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0061370","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0006355","count":5},{"id":"GO:0016310","count":4}]},{"hash":"395164221032378958","title":"Inner ear morphogenesis and auditory neuron development","description":"The cluster\u2019s top GO terms cluster around inner ear morphogenesis and sensory perception of sound, with supporting terms for neuronal morphogenesis (dendrite and dendritic spine morphogenesis) and epithelial tight junction assembly, which are all relevant to the development and function of the auditory organ and its neural connections. Notch pathway regulation fits into developmental patterning in the ear epithelium. A couple of plant-related terms appear as noise but do not override the ear-centric theme.","confidence":"High","size":22,"edges":42,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0016358","count":2},{"id":"GO:0070830","count":2},{"id":"GO:0042472","count":2},{"id":"GO:0045746","count":2}]},{"hash":"1915121861727531242","title":"Neural cell adhesion and synapse formation","description":"The cluster is enriched for GO terms on cell adhesion (heterophilic/homophilic) and regulation of actin cytoskeleton by cell-cell adhesion, plus axon guidance and synapse assembly, pointing to neural connectivity and synapse development. Some terms (bone ossification, NK cell regulation) are more peripheral, but the dominant theme is neuronal adhesion and synaptic organization.","confidence":"Medium","size":22,"edges":74,"triangles":61,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":15},{"id":"GO:0007156","count":13},{"id":"GO:0002859","count":11},{"id":"GO:0021637","count":11},{"id":"GO:0090138","count":11}]},{"hash":"1951697537046854099","title":"Phospholipid remodeling and endocytosis","description":"This cluster centers on remodeling various phospholipids (phosphatidylserine, phosphatidylinositol, phosphatidylcholine, phosphatidylethanolamine) and on receptor-mediated endocytosis and internalization, with Rho signaling likely coordinating cytoskeletal changes during these processes. The presence of paranodal junction assembly and myoblast fusion hints at membrane organization and cell-cell interfaces, all linked through lipid signaling and trafficking pathways. Overall, the terms point to a membrane-dynamics and lipid-metabolism module affecting endocytosis and cell junctions.","confidence":"Medium","size":22,"edges":76,"triangles":18,"max_degree":12,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0030913","count":8},{"id":"GO:0048260","count":8},{"id":"GO:0035023","count":7},{"id":"GO:0031623","count":7},{"id":"GO:0007520","count":7}]},{"hash":"2252126271111058347","title":"Embryonic development and vascular remodeling","description":"This cluster centers on developmental processes such as in utero embryonic development, sprouting angiogenesis, EMT, and bone formation, suggesting a coordinated program of tissue growth and vascular remodeling during development. The presence of smooth muscle proliferation and estradiol response supports a hormone-influenced developmental context. Some terms (heme biosynthesis, LPS response) are peripheral or ancillary, reflecting auxiliary metabolic or immune aspects rather than core functions. Overall, the dominant theme is developmental progression with vascular and tissue remodeling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006783","count":4},{"id":"GO:0032496","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0043154","count":2}]},{"hash":"153074612397591105","title":"Neural development and sensory synapse formation","description":"These proteins are enriched for terms related to nervous system development, axon fasciculation, synapse assembly, and myelination, as well as sensory functions like detecting mechanical stimuli involved in hearing and otolith morphogenesis. This combination points to a cluster involved in neural connectivity and maturation of sensory pathways (including auditory structures), with cell\u2013cell adhesion supporting synapse formation. An outlier innate immune term may reflect annotation noise rather than a primary function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":7},{"id":"GO:0007413","count":6},{"id":"GO:0050910","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0007275","count":5}]},{"hash":"2204989649818376738","title":"Vertebrate Eye Development and Neural Patterning","description":"The cluster is dominated by GO terms for retina development, camera-type eye development, and embryonic eye morphogenesis, with additional terms for brain segmentation and rhombomere development, pointing to vertebrate eye formation and hindbrain patterning as the core theme. Transcription by RNA polymerase II terms suggest regulation of these developmental programs. Some outliers (heart/osteoblast development) are broader but do not override the eye/neural signal. ","confidence":"High","size":22,"edges":197,"triangles":976,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0006366","count":10},{"id":"GO:0002087","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0002076","count":9}]},{"hash":"132199155291276597","title":"Adrenergic signaling and neurovascular regulation","description":"This cluster is dominated by GO terms for adrenergic receptor signaling (MAPK-activating and PLC-activating), norepinephrine-epinephrine\u2013mediated vasoconstriction, and blood pressure regulation, with additional signals related to dopaminergic synaptic transmission. Together they point to a coherent theme of sympathetic signaling affecting neural and vascular function, with some immune/coagulation associations likely reflecting shared signaling cross-talk.","confidence":"High","size":22,"edges":144,"triangles":381,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":17},{"id":"GO:0002035","count":16},{"id":"GO:0001963","count":16},{"id":"GO:1900453","count":16},{"id":"GO:0001994","count":16}]},{"hash":"1537467658721271464","title":"Mitochondrial aminoacyl-tRNA synthetases","description":"The terms are dominated by mitochondrial tRNA aminoacylation for multiple amino acids (glycyl-, alanyl-, histidyl-, threonyl-, seryl-tRNA) along with a translation-related process (translation and regulation of translational fidelity). This points to a cohesive mitochondrial protein synthesis module centered on aminoacyl-tRNA synthetases that charge mitochondrial tRNAs, consistent with a functional cluster rather than unrelated processes.","confidence":"High","size":22,"edges":73,"triangles":122,"max_degree":17,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0070150","count":7},{"id":"GO:0097056","count":7},{"id":"GO:0070143","count":7},{"id":"GO:0006450","count":7}]},{"hash":"607661334293351027","title":"GPCR-cAMP signaling in cardiovascular function","description":"The top GO terms point to adenylate cyclase-activating GPCR signaling pathways (dopamine, adrenergic receptors) and cAMP-mediated signaling, with clear cardiovascular relevance (heart development, blood pressure regulation). While a few terms touch on phototransduction and energy metabolism, the central, shared theme is GPCR-triggered cAMP signaling pertinent to heart and vascular function.","confidence":"High","size":22,"edges":13,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0045777","count":20},{"id":"GO:0007507","count":19},{"id":"GO:0007603","count":19}]},{"hash":"199862178622686976","title":"Visual-Dopaminergic Neural Signaling","description":"This cluster is dominated by GO terms tied to neural processing: visual perception, visual learning, and dopaminergic synaptic transmission, along with a behavioral response to cocaine and ERK1/2 cascade regulation, which are characteristic of CNS signaling and reward pathways. The convergence on visual and dopaminergic signaling and cocaine-related responses suggests proteins involved in sensory processing and reward-related neural activity. Some terms like prostaglandin response, pain, heart development, brain renin-angiotensin system, and macrophage chemotaxis are more peripheral, possibly reflecting broader neuro-immune or developmental contexts, but the core theme remains visual/dopaminergic neural signaling. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":22},{"id":"GO:0070374","count":22},{"id":"GO:0001963","count":22},{"id":"GO:0048148","count":22},{"id":"GO:0071380","count":22}]},{"hash":"1065351654451214518","title":"Innate Antiviral Defense","description":"The cluster is strongly characterized by innate immune and antiviral terms (innate immune response, defense response to virus, negative regulation of viral genome replication, cytokine-mediated signaling). A subset of terms about DNA repair and chromatin localization suggests nuclear processes that can intersect antiviral responses, but the clearest theme across the top terms is antiviral innate immunity.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0071479","count":2},{"id":"GO:0006281","count":2}]},{"hash":"832343665124657183","title":"Ubiquitin-Proteasome ERAD and protein quality control","description":"The top GO terms are dominated by ubiquitin-dependent proteolysis, ERAD, and polyubiquitination, pointing to a central role in tagging misfolded or regulated proteins for degradation via the ubiquitin-proteasome system. The unfolded protein response reinforces a protein quality-control theme. Immune and development terms appear as secondary associations, but the strongest signal is ubiquitin-mediated degradation and ERAD, making this a coherent cluster for protein quality control functions.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0045087","count":3}]},{"hash":"288456295991438955","title":"Wnt-driven neural development and axon guidance","description":"This cluster features several neural-development\u2013related terms: axonal fasciculation, cortical radial glia-guided migration, and negative regulation of axon extension, alongside the involvement of the Wnt signaling pathway. These repeatedly point to roles in neural patterning, axon pathfinding, and cortical development. Other terms about ER structure, peroxisome organization, steroid biosynthesis, and nuclear pore assembly likely reflect general cellular maintenance rather than core function of the cluster, so the dominant theme remains neural development and axon guidance.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0060317","count":2},{"id":"GO:0071787","count":2},{"id":"GO:0032581","count":2}]},{"hash":"289465681130442941","title":"Embryonic patterning and organ development","description":"The cluster shows enrichment for embryonic development themes, including left/right pattern formation, endocrine system development, placental differentiation, and pancreatic cell development, suggesting a coherent role in embryonic axis specification and organogenesis. While basic cellular processes like splicing and DNA repair appear, the developmental terms provide the main theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0060972","count":1},{"id":"GO:1903026","count":1},{"id":"GO:0060707","count":1}]},{"hash":"127121315946766211","title":"Neuronal Adrenergic-Dopaminergic Signaling","description":"The top GO terms point to signaling pathways driven by adrenergic receptors (MAPK, PLC, adenylyl cyclase) and dopaminergic synaptic transmission, all within a brain/neuronal context and linked to vascular regulation (vasoconstriction, blood pressure) and synaptic plasticity. A few items (e.g., thymocyte differentiation) are peripheral outliers, but the dominant theme is CNS adrenergic and dopaminergic signaling influencing synaptic function and cardiovascular control.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"1127545431453035797","title":"Taste and Vision GPCR Signaling","description":"This cluster is dominated by sensory perception terms (taste, bitter taste, visual perception) and regulation of opsin signaling, plus a GPCR signaling context (adenylate cyclase-activating pathway). This suggests GPCR-driven signaling in vision and gustation as the core theme, with some cardiovascular and metabolic terms as peripheral context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":5},{"id":"GO:0022900","count":5},{"id":"GO:0035025","count":5},{"id":"GO:0045777","count":5},{"id":"GO:0050909","count":4}]},{"hash":"1348441589716762422","title":"Ubiquitin-Dependent Antiviral Immune Signaling","description":"The cluster combines ubiquitin-mediated protein catabolism and ERAD with innate immune defense and antiviral signaling (including TNF/JNK pathways and K63-linked ubiquitination), indicating a cohesive function in ubiquitin-regulated antiviral immune responses.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0030433","count":7},{"id":"GO:0051865","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":7}]},{"hash":"2163459790643963648","title":"Neural sphingolipid signaling and NF-\u03baB regulation","description":"The cluster shows a strong mix of sphingolipid metabolism terms (sphingosine biosynthetic and catabolic processes) alongside brain development and NF-\u03baB\u2013related regulatory pathways, plus inflammatory signaling (IL-1\u03b2 production) and proliferation signals. This suggests a common theme where sphingolipid mediators influence NF-\u03baB\u2013driven signaling in neural development and related inflammatory responses, making a cohesive label appropriate.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007420","count":9},{"id":"GO:0010800","count":8},{"id":"GO:0046521","count":8},{"id":"GO:0046512","count":8},{"id":"GO:0051092","count":8}]},{"hash":"680968763562688092","title":"Embryonic development and morphogenesis","description":"The proteins are enriched across many development-related processes, including left/right patterning, mesoderm and organ development, and tissue morphogenesis (cartilage, hair follicles, palate, etc.), indicating a broad role in embryogenesis rather than a single pathway.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":22},{"id":"GO:0060806","count":22},{"id":"GO:0060707","count":22},{"id":"GO:0035270","count":22},{"id":"GO:0003323","count":22}]},{"hash":"1481209933023525857","title":"Dermal and connective tissue development","description":"These terms cluster around tissue development and remodeling, notably skin morphogenesis, collagen fibril organization, and differentiation of vascular and cartilage-related lineages, with Wnt signaling and cell\u2013substrate adhesion indicating coordinated extracellular matrix\u2013mediated development. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043589","count":4},{"id":"GO:0048662","count":3},{"id":"GO:0016055","count":3},{"id":"GO:0010906","count":3},{"id":"GO:0030199","count":3}]},{"hash":"441872758095514952","title":"Placental and embryonic development","description":"The top GO terms cluster around embryonic development and placentation\u2014trophoblast giant cell differentiation, placental development, left-right pattern formation, EMT in endocardial cushion formation, and cartilage morphogenesis\u2014supported by endocrine system development and transcriptional regulation during development. Immune-related terms (complement activation, defense against Gram-positive bacteria) are present but seem less central to the main theme. Overall, the proteins appear to be involved in placental and broader embryonic development with related morphogenetic processes.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0060707","count":5},{"id":"GO:0003323","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0060972","count":4}]},{"hash":"1391974781720864822","title":"Taste and pheromone chemosensation","description":"The top GO terms cluster around detection and perception of chemical stimuli, especially taste and pheromones, including bitter taste detection. This points to chemosensory receptors and signaling components as the core function, with some secondary signals (dopamine pathway, prostaglandin response) and transport processes accompanying them. Overall, the theme is chemosensory perception and related signaling.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":6},{"id":"GO:0007606","count":6},{"id":"GO:0050909","count":5},{"id":"GO:0001580","count":5},{"id":"GO:0008283","count":3}]},{"hash":"2105726789720034809","title":"Germline meiosis and DNA repair","description":"The top GO terms cluster around germ cell development, meiotic gene conversion and mating-type locus recombination, and DNA damage response pathways (including p53-mediated apoptosis and cell cycle regulation), indicating a theme of germline/meiotic processes coordinated with DNA damage repair. Energy metabolism terms are present but appear secondary to the central germline/meiosis-dna repair pattern.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007281","count":5},{"id":"GO:0042771","count":5},{"id":"GO:0007050","count":5},{"id":"GO:0045190","count":4},{"id":"GO:0031573","count":4}]},{"hash":"346400712099942367","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0051865","count":9},{"id":"GO:0002635","count":8},{"id":"GO:0061158","count":8},{"id":"GO:0043029","count":8}]},{"hash":"839281173561467391","title":"Mitochondrial Transport and Membrane Dynamics","description":"The cluster is enriched for transmembrane transport of a variety of cofactors and metabolites (NAD, thiamine pyrophosphate, deoxynucleotides, ornithine, glycine) and includes terms for mitochondrial membrane fission and regulation of membrane permeability. This points to a cohesive theme of mitochondrial transport and membrane remodeling rather than dispersed functions. The liver regeneration term may reflect mitochondrial involvement in hepatocyte recovery, reinforcing a mitochondria-centric interpretation.","confidence":"High","size":21,"edges":68,"triangles":88,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0035352","count":16},{"id":"GO:0034198","count":16},{"id":"GO:0000066","count":16},{"id":"GO:0097421","count":16},{"id":"GO:0036233","count":16}]},{"hash":"483282480381235605","title":"Neural differentiation and dendrite morphogenesis","description":"The cluster\u2019s terms are dominated by neural development and dendrite formation, including regulation of dendrite morphogenesis and cerebellar granule cell differentiation, with supporting signals from Wnt pathway activity; a few terms touch on other tissues, but neural differentiation appears to be the main theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048814","count":2},{"id":"GO:0055002","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0045444","count":2}]},{"hash":"1803380017202039693","title":"Embryonic morphogenesis and mesodermal development","description":"These proteins appear linked to embryo development and tissue formation, especially mesoderm-derived tissues and craniofacial remodeling. Top terms include pericardium morphogenesis, mesodermal cell differentiation, palatal shelf morphogenesis, and collagen fibril organization, along with transcription and chromatin remodeling. Collectively, this suggests a developmental and morphogenetic module rather than a single metabolic pathway.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0003344","count":4},{"id":"GO:0048333","count":4},{"id":"GO:1990134","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1159610150174955176","title":"Unknown","description":"This cluster includes GO terms spanning immune response, apoptosis, muscle contraction and assembly, kidney filtration, mitotic spindle and cell division, organelle inheritance, and even a yeast-specific actin transport process, indicating no single cohesive function. The lack of interconnections among terms and the diversity suggest a heterogeneous collection rather than a unified biological module. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0071963","count":7},{"id":"GO:0055003","count":7},{"id":"GO:0090307","count":7}]},{"hash":"2118587576208365520","title":"Embryonic skeletal and heart development with proliferation","description":"The cluster\u2019s top GO terms center on embryonic cranial skeletal morphogenesis, cardiac neural crest\u2013driven heart development, and angiogenesis, alongside DNA replication and centrosome cycle processes. This points to a shared theme of embryonic development that involves craniofacial skeleton formation, heart development, and concurrent cell proliferation, even though a few terms (e.g., biofilm formation, dsRNA response) appear unrelated and may reflect annotation noise.","confidence":"Medium","size":21,"edges":114,"triangles":277,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":21},{"id":"GO:0007098","count":21},{"id":"GO:0010571","count":21},{"id":"GO:0006260","count":21},{"id":"GO:0033129","count":20}]},{"hash":"2021844486525572161","title":"Diverse membrane transporters","description":"The top GO terms cluster around transmembrane transport of a wide range of substrates\u2014xenobiotics, potassium ions, vitamins, sugars (arabinose, galactose), nitrate/nitrite, and sialic acid\u2014with an additional role in neurotransmitter loading into synaptic vesicles. This pattern points to a set of membrane transporter proteins that mediate uptake and release of diverse solutes, including neurotransmitters in neurons, rather than a single specific substrate pathway.","confidence":"High","size":21,"edges":58,"triangles":49,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":17},{"id":"GO:0071805","count":17},{"id":"GO:0035461","count":17},{"id":"GO:0098700","count":16},{"id":"GO:0015751","count":16}]},{"hash":"849926717921377805","title":"DNA replication, repair, and meiotic development","description":"The cluster is dominated by GO terms for DNA replication, replication-born double-strand break repair via sister chromatid exchange, meiosis I, and spermatid development, with additional signals of DNA damage responses to xenobiotics and chemotherapeutics. This supports a core theme of genomic maintenance during replication and germline meiosis, with some peripheral associations to brain development and xenobiotic stress. ","confidence":"High","size":21,"edges":186,"triangles":987,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051260","count":6},{"id":"GO:0006260","count":6},{"id":"GO:0007420","count":6},{"id":"GO:0042493","count":5},{"id":"GO:0009636","count":5}]},{"hash":"935342723204191810","title":"Mammary gland development and lactation","description":"The cluster is enriched for terms like lactose biosynthetic process and mammary gland development, alongside glycosphingolipid and proteoglycan biosynthesis and wound-healing\u2013related angiogenesis, all pointing to functions in mammary tissue development, lactation, and extracellular matrix remodeling. Some reproduction-related terms appear but are less representative of the core theme.","confidence":"Medium","size":21,"edges":130,"triangles":369,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0006688","count":3},{"id":"GO:0060046","count":3},{"id":"GO:0005989","count":3}]},{"hash":"828486865277215506","title":"SRP-Dependent ER Targeting and Secretory Pathway","description":"The top GO terms cluster around SRP-dependent cotranslational targeting to the endoplasmic reticulum membrane, post-translational targeting to ER membrane, and membrane protein targeting, plus vesicle formation and ERAD. This points to a cohesive set of proteins involved in directing nascent and mature polypeptides into the ER and through the secretory pathway, including quality control processes.","confidence":"High","size":21,"edges":176,"triangles":853,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0070676","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0000902","count":3}]},{"hash":"1198260759522350334","title":"Signaling and cell cycle regulation","description":"This cluster\u2019s top GO terms span several signaling pathways (Wnt, NOD2, NF-kappaB regulation), along with cell growth, cell cycle, telomere maintenance, and vascular development, indicating a broad collection of proteins involved in signaling networks that regulate proliferation, fate decisions, and growth rather than a single canonical pathway. The diversity suggests a general role in coordinating signaling and growth-related processes. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032088","count":9},{"id":"GO:0016055","count":8},{"id":"GO:0097284","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0032212","count":7}]},{"hash":"639471422188385994","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000398","count":5},{"id":"GO:0071456","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0000480","count":4},{"id":"GO:0000462","count":4}]},{"hash":"1086474913533895490","title":"Neural tube and cranial morphogenesis","description":"This cluster centers on neural development and head formation, with GO terms like neural tube closure, forebrain development, embryonic cranial skeleton morphogenesis, and general multicellular development, plus transcriptional regulation via DNA-templated transcription. While there are broader processes such as mitotic cell cycle and histone acetylation, the dominant theme is neural patterning and cranial morphogenesis, suggesting these proteins function together in early brain and skull development. An immune-related term appears incidental. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0006349","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0001843","count":4},{"id":"GO:0030900","count":4}]},{"hash":"914157380579256112","title":"mRNA Splicing and Post-Transcriptional Regulation","description":"These proteins are enriched for GO terms related to mRNA processing and regulating mature mRNA: splicing via the spliceosome, splice site recognition, mRNA polyadenylation, export from the nucleus, stabilization, and ncRNA/miRNA-mediated silencing of translation, plus translation preinitiation complex formation. Together they define a cohesive module centered on post-transcriptional control of gene expression rather than transcriptional processes, justifying the label.","confidence":"High","size":21,"edges":21,"triangles":8,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":17},{"id":"GO:0045292","count":17},{"id":"GO:0006376","count":13},{"id":"GO:0006406","count":13},{"id":"GO:0048255","count":13}]},{"hash":"1633974965851025673","title":"Sound perception and neural development","description":"Based on GO terms such as sensory perception of sound, detection of mechanical stimulus involved in sensory perception of sound, nervous system development, optic nerve morphogenesis, corticospinal tract morphogenesis, and positive regulation of synapse assembly, the cluster most strongly points to proteins involved in auditory sensing and broader neural morphogenesis/synapse formation. Some terms like mast cell degranulation and potassium transport are less central, but the dominant theme is neural development and sensory processing.","confidence":"High","size":21,"edges":30,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0050910","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0007626","count":2}]},{"hash":"927294241602650942","title":"Craniofacial Bone Formation and ECM Remodeling","description":"The top terms indicate strong involvement in extracellular matrix organization and remodeling (collagen fibril organization, ECM disassembly), skeletal development including cranial skeleton morphogenesis and endochondral ossification, and mineralization processes such as bone mineralization and amelogenesis. This points to a coherent function in craniofacial skeletal development with ECM remodeling supporting mineral deposition and tooth enamel formation, with some supporting terms like substrate adhesion and phosphate homeostasis reinforcing the mineralization context.","confidence":"High","size":21,"edges":19,"triangles":0,"max_degree":19,"top_function":"wound healing","top_go_terms":[{"id":"GO:0030199","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0001958","count":5},{"id":"GO:0022617","count":4},{"id":"GO:0030643","count":4}]},{"hash":"1662145734441189347","title":"Post-transcriptional mRNA processing and regulation","description":"This cluster is dominated by GO terms tied to mRNA splicing regulation, splice site recognition, mRNA export, stability, poly(A) tail regulation, and miRNA-mediated silencing, plus translation initiation assembly. Together they point to a cohesive group of proteins governing mRNA fate after transcription\u2014processing, export, stability, and translational control\u2014especially in stress and regulatory ncRNA contexts.","confidence":"High","size":21,"edges":127,"triangles":330,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0031047","count":13},{"id":"GO:0048025","count":13},{"id":"GO:0006376","count":12},{"id":"GO:0006406","count":12}]},{"hash":"360993730676038419","title":"Neuronal synaptic plasticity and spine morphogenesis","description":"The set of GO terms centers on synaptic function and structure: actin filament organization, dendritic spine morphogenesis, postsynaptic density assembly, and long-term synaptic depression, along with positive regulation of glutamatergic transmission and vocalization behavior. Regulation of transcription and a MyD88-dependent TLR4 signaling pathway term suggest transcriptional modulation and innate signaling in neurons that can influence synaptic remodeling. Together, these imply a neuron-focused program of synaptic plasticity and spine dynamics.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":5},{"id":"GO:0007527","count":5},{"id":"GO:0035660","count":5},{"id":"GO:0097107","count":2},{"id":"GO:0050894","count":2}]},{"hash":"1586646910601576884","title":"Adherens junction localization and cytoskeleton remodeling","description":"The top GO terms point to proteins localized to adherens junctions and to Rho-mediated cytoskeletal dynamics (Rho signaling, its regulation, lamellipodium assembly), as well as related processes such as vascular permeability and tissue morphogenesis. Although there are no reported edges linking the proteins in this cluster, the recurring theme across tissues (epithelial/endothelial junctions, neurons, gut morphogenesis) is junction-associated cytoskeleton remodeling governed by Rho GTPases. This supports a cohesive label focusing on junction localization and actin dynamics.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071896","count":4},{"id":"GO:0032930","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0043114","count":3},{"id":"GO:0007266","count":3}]},{"hash":"108948190655840802","title":"Host-Pathogen Interaction and Immune Modulation","description":"Top GO terms cluster around immune signaling and pathogen interaction (interleukin-2 production, symbiont- and virus-mediated host RNA and ubiquitin-like protein modifications, ISG15 conjugation suppression, and viral replication) alongside mitochondrial energy processes and transcription. This suggests a theme where host immune pathways and pathogen strategies converge, with some linkage to cellular energy and gene expression. Confidence: Medium","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042775","count":3},{"id":"GO:0070970","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0039595","count":2}]},{"hash":"1698355521563100384","title":"Endothelial cytoskeletal remodeling and angiogenesis signaling","description":"The terms point to actin cytoskeleton reorganization, Rho GTPase signaling, and ERK cascades, combined with endothelial lumen formation and vesicle trafficking between ER-Golgi and endosomes. Together these reflect cytoskeletal dynamics and membrane trafficking driving endothelial cell migration and sprouting angiogenesis; the circadian term is less connected but does not override the main theme.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0042747","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0035621","count":3},{"id":"GO:0097498","count":3}]},{"hash":"81223028814361192","title":"Endocytosis and Slit-Robo Signaling in Development","description":"This cluster is driven by endocytosis-related terms and Roundabout signaling (Slit-Robo), with strong associations to nervous system development and membrane transport, plus related developmental processes (kidney development) and immune cell movement. The combination suggests a theme of endocytosis-linked guidance/signaling pathways affecting development, particularly neural development, with possible immune interactions. Confidence: Medium","confidence":"","size":21,"edges":37,"triangles":10,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0048227","count":3},{"id":"GO:0001822","count":3},{"id":"GO:1903125","count":3}]},{"hash":"1150864128947047875","title":"Rho-mediated cytoskeletal remodeling and vascular permeability regulation","description":"The cluster centers on Rho signaling and lamellipodium assembly, indicating actin cytoskeleton remodeling and cell migration. It also includes terms related to vascular permeability, extravasation, and neutrophil function, suggesting a cohesive theme of leukocyte movement and vessel barrier regulation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":4},{"id":"GO:0030032","count":4},{"id":"GO:0060313","count":4},{"id":"GO:0043314","count":4},{"id":"GO:0002692","count":4}]},{"hash":"609812253622436240","title":"Neuroinflammation and Cortical Development","description":"This cluster centers on brain development and neural signaling, with strong signals for cerebral cortex development and glutamatergic synaptic transmission, plus inflammatory and immune-related pathways (IL-1 signaling, T cell receptor signaling) and apoptosis/JNK regulation. The convergence of neuronal maturation, synaptic activity, glial apoptotic control, and neuroimmune signaling supports a theme of neurodevelopment coupled with neuroinflammation.","confidence":"Medium","size":21,"edges":27,"triangles":3,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070498","count":4},{"id":"GO:0021987","count":4},{"id":"GO:0046330","count":3},{"id":"GO:0097194","count":3},{"id":"GO:0010467","count":3}]},{"hash":"1346095483862541337","title":"Epithelial junctions and vesicle trafficking","description":"This cluster centers on epithelial cell organization: tight junction assembly and apical/basal polarity maintenance, coupled with vesicle trafficking components (endosome localization and exosome secretion) and even ciliogenesis, suggesting a cohesive role in epithelial junctions and vesicle trafficking/exosome pathways. Confidence: High","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":3},{"id":"GO:1903553","count":2},{"id":"GO:0036010","count":2},{"id":"GO:0002775","count":2},{"id":"GO:1900198","count":2}]},{"hash":"1648517438924369410","title":"Neural development and morphogenesis","description":"Top GO terms show neurite guidance, neural crest migration, motor neuron differentiation, cerebral cortex regionalization, and limb morphogenesis, all pointing to neurodevelopmental patterning and associated morphogenetic processes. This cohesive theme justifies a label focused on neural development and morphogenesis across CNS and PNS contexts.","confidence":"High","size":21,"edges":21,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0050884","count":2},{"id":"GO:0042733","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0001755","count":2}]},{"hash":"186976900238568054","title":"Immune signaling and lymphocyte activation","description":"The top GO terms are strongly centered on immune processes: innate signaling via MyD88-dependent TLR4, cellular responses to lipoteichoic acid, cytokine production, immunoglobulin production, and B cell activation. Although there are some developmental and transcription-regulation terms present, the dominant theme across the cluster is immune response signaling and lymphocyte activation, supporting a cohesive immune function label.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":6},{"id":"GO:0007527","count":6},{"id":"GO:0035660","count":6},{"id":"GO:0048820","count":3},{"id":"GO:0030900","count":2}]},{"hash":"874942884401255228","title":"ER-Golgi and endosomal vesicle trafficking","description":"The top terms cluster around intracellular transport and vesicle movement, especially COPII-mediated ER-to-Golgi traffic, endosome-to-Golgi/lysosome targeting, and endosome recycling, indicating a cohesive vesicle trafficking function.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":3},{"id":"GO:0090110","count":3},{"id":"GO:0045737","count":3},{"id":"GO:0006622","count":2},{"id":"GO:0048227","count":2}]},{"hash":"1702401455141839085","title":"Signaling Pathways and Receptor Localization","description":"The prominent GO term is GO:0050852 - T cell receptor signaling pathway (14 proteins), indicating a core theme of receptor-mediated signal transduction. Other top terms point to GPCR/cGMP signaling, receptor trafficking to synapses, and responses to TGF-beta, suggesting involvement of signaling cascades and how receptors are localized within cells. There are additional terms about epithelial polarity and nucleotide biosynthesis that are less central but can intersect with signaling networks in certain contexts. Taken together, the cluster seems enriched for proteins involved in signaling and receptor localization rather than a single metabolic or structural function, hence the label.","confidence":"Medium","size":21,"edges":21,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":14},{"id":"GO:0007608","count":9},{"id":"GO:0071321","count":9},{"id":"GO:0010754","count":9},{"id":"GO:0071560","count":8}]},{"hash":"1090769667457482449","title":"Phosphatase Signaling in Neural and Muscle Development","description":"Based on the prominent GO terms, the cluster centers on phosphatase activity (tyrosine and PI/inositol phosphate dephosphorylation) and associated signaling that influences neural development (neuron development, myelination) and skeletal muscle growth, with supporting roles in proteasomal regulation and GTPase activity. This suggests a cohesive theme of phosphatase-driven signaling coordinating neural and muscle development and cellular homeostasis.","confidence":"Medium","size":21,"edges":134,"triangles":415,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0035335","count":11},{"id":"GO:0032435","count":9},{"id":"GO:0048666","count":9},{"id":"GO:0031642","count":9},{"id":"GO:0046856","count":9}]},{"hash":"1692138567647842940","title":"Unknown","description":"The top GO terms span bone ossification, neural signaling (sodium channel clustering and mechanosensation), immune regulation (cytokine production, NK cell activity, hypersensitivity), synapse organization, and angiogenesis, with no single unifying function that ties them together, suggesting multifunctional proteins without a cohesive cluster-level theme.","confidence":"","size":21,"edges":156,"triangles":595,"max_degree":20,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043931","count":16},{"id":"GO:0045162","count":16},{"id":"GO:0002859","count":15},{"id":"GO:0002720","count":15},{"id":"GO:0050808","count":15}]},{"hash":"1926279638393868514","title":"Unknown","description":"The GO terms are highly diverse: epoxygenase P450 pathway, phospholipid dephosphorylation, stilbene catabolic process, tryptophan biosynthesis, general dephosphorylation, lipopolysaccharide biosynthesis, metal ion transport (cadmium, copper), and calcium homeostasis. This mixture lacks a single cohesive function or pathway that links the proteins, suggesting the cluster represents a heterogeneous set of metabolic and transport roles rather than a focused biological process. ","confidence":"","size":21,"edges":170,"triangles":821,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0097755","count":5},{"id":"GO:0019373","count":5},{"id":"GO:0046839","count":5},{"id":"GO:0046272","count":5},{"id":"GO:0000162","count":4}]},{"hash":"348287611270296966","title":"Embryonic heart morphogenesis and left-right patterning","description":"This cluster shows strong enrichment for ventricular cardiac muscle tissue morphogenesis, left/right pattern formation, and embryonic development, coupled with transcription by RNA polymerase II and transcriptional regulation, suggesting a core role in heart development and developmental gene control.","confidence":"High","size":21,"edges":85,"triangles":87,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0055010","count":5},{"id":"GO:0060972","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0001701","count":5}]},{"hash":"225530569308206197","title":"Hematopoietic differentiation and transcriptional regulation","description":"This cluster centers on hematopoietic lineage differentiation (granulocyte, megakaryocyte, erythrocyte) with accompanying transcriptional control signals (RNA Pol II regulation and chromatin modifications). While there are additional embryonic development terms and a few non-hematopoietic hints, the strongest, recurrent terms point to blood cell lineage specification governed by transcriptional and epigenetic regulation.","confidence":"Medium","size":21,"edges":62,"triangles":57,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0001701","count":9},{"id":"GO:0043046","count":8},{"id":"GO:0045654","count":8},{"id":"GO:0034720","count":8}]},{"hash":"1931012231312308316","title":"Ubiquitin-Dependent Proteolysis in Neural Development","description":"The cluster is dominated by ubiquitin-related processes (ubiquitin-dependent proteolysis, protein polyubiquitination) with supporting neural development terms (synapse assembly, neural tube closure) and DNA replication/cell-cycle signaling, suggesting proteins tied together by ubiquitination affecting neural development and related pathways.","confidence":"High","size":21,"edges":10,"triangles":0,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:1903378","count":10},{"id":"GO:0071406","count":9},{"id":"GO:0060386","count":9},{"id":"GO:1902916","count":9}]},{"hash":"1932309726034830545","title":"Unknown","description":"The GO terms span both nuclear chromatin remodeling/transcription regulation and extracellular/hemostatic processes, with no clear single function linking them. The lack of edges and cohesive theme suggests these proteins do not share a common, interpretable function in this cluster. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0035066","count":6},{"id":"GO:0000183","count":6},{"id":"GO:0043044","count":6},{"id":"GO:0030574","count":5}]},{"hash":"781394500575226485","title":"Neuroimmune Catecholamine Signaling","description":"Top GO terms indicate neural and immune signaling linked to catecholamines: dopaminergic synaptic transmission, adrenergic receptor\u2013mediated pathways (MAPK and PLC activation), brain renin-angiotensin system, norepinephrine-epinephrine\u2013driven vasoconstriction, and immune modulation (negative regulation of TNF production and neutrophil chemotaxis). The shared theme is signaling cascades driven by catecholamines that influence both neural communication and inflammatory responses. The absence of physical interaction edges suggests this cluster groups functional signaling processes rather than a single multimeric complex.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0032720","count":20},{"id":"GO:0002035","count":19},{"id":"GO:0001963","count":19},{"id":"GO:1900453","count":19},{"id":"GO:0001994","count":19}]},{"hash":"1320405173805194627","title":"Actin cytoskeleton remodeling and cell migration","description":"The top terms cluster around cytoskeletal dynamics and motility: Rho signaling, lamellipodium assembly, sarcomere organization, and cell adhesion, all pointing to actin-driven rearrangements that enable movement and contact with other cells. Developmental terms are present but secondary, suggesting the core theme is actin-based remodeling and migration.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:1900042","count":3},{"id":"GO:0045214","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0045765","count":3}]},{"hash":"430647102038945396","title":"Development and ECM Remodeling","description":"The cluster is enriched for developmental cues (midbrain development, multicellular organism growth, amelogenesis) and for extracellular matrix remodeling (ECM disassembly, tissue remodeling). The inclusion of transcriptional-regulation terms also fits a developmental program. While some terms are more general or immune-related, the overarching pattern points to a group of proteins involved in tissue morphogenesis and remodeling during growth.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":8},{"id":"GO:0044130","count":7},{"id":"GO:0007586","count":6},{"id":"GO:0035264","count":6}]},{"hash":"558005007430524743","title":"Neuronal GPCR Signaling and Sensory Processing","description":"The proteins in this cluster are enriched for neuron-related signaling functions, especially G protein-coupled receptor pathways (adenylate cyclase-activating GPCR signaling), neuropeptide signaling, and sensory/pain processing (sensory perception of pain, regulation of sensory perception of pain). Behavioral and perceptual associations such as prepulse inhibition and response to amphetamine further support a neural processing theme, with a secondary indication of neuronal energy needs from the electron transport chain. This combination best fits a cohesive label around neuronal signaling and sensory/pain processing.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0035025","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0008542","count":11}]},{"hash":"2292094919207891776","title":"Brain adrenergic and dopaminergic signaling","description":"The GO terms point to neural signaling in the brain, including dopaminergic synaptic transmission, brain renin-angiotensin system, and adrenergic receptor\u2013driven pathways (MAPK, PLC, and cAMP modulation) involved in vasoregulation and blood pressure control, suggesting a cohesive theme of brain adrenergic/dopaminergic signaling; a few terms may be ancillary, but the dominant pattern is clear.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":21},{"id":"GO:0001963","count":21},{"id":"GO:1900453","count":21},{"id":"GO:0001994","count":21},{"id":"GO:0071883","count":21}]},{"hash":"642629181761171736","title":"Axon guidance and synapse development in CNS","description":"The cluster is dominated by neural development and synaptic organization terms, including corpus callosum development, axonal fasciculation, retinal ganglion cell axon guidance, postsynaptic density assembly, dendritic spine morphogenesis, and synaptic plasticity. This suggests proteins work together to establish neural circuits, guide axons, and assemble/remodel synapses.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":6},{"id":"GO:0007413","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0097107","count":5},{"id":"GO:0007605","count":5}]},{"hash":"147335143776101156","title":"Epidermal Differentiation and Keratinization","description":"The cluster is dominated by GO terms for keratinocyte differentiation, keratinization, and epidermis development, with peptide cross-linking supporting keratin network formation. While other developmental terms appear, the strongest and most frequent signals point to epidermal maturation and keratinization as the core function of this protein group.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030216","count":7},{"id":"GO:0031424","count":7},{"id":"GO:0018149","count":7},{"id":"GO:0008544","count":7},{"id":"GO:0060972","count":6}]},{"hash":"978137391186944916","title":"Rho-actin cytoskeleton remodeling and cell junctions","description":"Based on the top GO terms, the cluster is dominated by regulation of Rho signaling, actin cytoskeleton organization, and microvillus assembly, pointing to dynamic cytoskeletal remodeling and maintenance of barrier/junctional structures in epithelial and other cells. Additional terms like activation of GTPase activity and Golgi localization support trafficking and signaling integration. A few terms reference neuronal processes, but the core theme remains actin dynamics and cell\u2013cell interfaces.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:0090557","count":7},{"id":"GO:0030036","count":6},{"id":"GO:0090630","count":5},{"id":"GO:0019933","count":5}]},{"hash":"2244276048978780739","title":"Inflammation, coagulation, and angiogenesis cluster","description":"This set is dominated by GO terms for acute-phase inflammatory response, blood coagulation, and fibrinolysis, with an additional signal for angiogenesis regulation, suggesting a shared theme of inflammatory and hemostatic processes and vascular remodeling. Other terms like digestion, transcription, and ubiquitin processes appear less central to the cluster\u2019s core function. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006953","count":5},{"id":"GO:0007586","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0002018","count":3},{"id":"GO:0042730","count":3}]},{"hash":"425977340576636742","title":"Rho-GTPase-driven synaptic plasticity","description":"The top GO terms center on regulation of Rho signaling and GTPase activity, along with synaptic plasticity and excitatory signaling (positive regulation of synapse structure, excitatory postsynaptic potential, and long-term depression), all of which point to neuronal signaling and activity-dependent modulation. A few ribosomal RNA maturation terms and a mitotic spindle orientation term are less directly connected, but the dominant theme is Rho/GTPase-mediated regulation of synaptic function and plasticity in neurons.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000132","count":3},{"id":"GO:0000466","count":3}]},{"hash":"1448054857808658291","title":"Methylation-driven chromatin regulation","description":"The top GO terms are dominated by various methylation processes (rRNA, lysine, arginine, N-terminal methylation) and by chromatin-related outcomes (rDNA heterochromatin formation, transcriptional regulation). This suggests a cohesive theme where methylation events modulate chromatin structure and gene expression.","confidence":"High","size":20,"edges":93,"triangles":174,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031167","count":13},{"id":"GO:0018027","count":11},{"id":"GO:0018013","count":9},{"id":"GO:0000183","count":9},{"id":"GO:0001300","count":7}]},{"hash":"1532791134632268487","title":"Vertebrate Development and Proteostasis","description":"Top terms point to development across multiple tissues (neuron projection, skeletal, lens differentiation) with concurrent protein regulation and turnover (ubiquitination, proteasome activity, histone acetylation, ribosome maturation). The cluster thus reflects a general developmental program coupled with proteostatic control, rather than a single precise pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0031175","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0050909","count":3}]},{"hash":"2097227835562370514","title":"Rho/GTPase\u2013Mediated Actin Remodeling in Heart Development","description":"This cluster centers on Rho signaling and GTPase activity, with lamellipodium and actin cortex assembly, linking cytoskeletal remodeling to cell migration and heart development; the Wnt pathway term adds a broader developmental context, but the dominant theme is actin dynamics regulated by Rho/GTPases.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0016055","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0032516","count":4},{"id":"GO:0007205","count":4}]},{"hash":"302167986815051763","title":"Developmental signaling and chromatin regulation","description":"This cluster centers on signaling responses (notably TGF-beta stimulus, phosphorylation, GTPase activity) coupled with developmental processes (brain and male gonad development) and chromatin organization, suggesting proteins that coordinate developmental signaling with transcriptional/chromatin regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071560","count":7},{"id":"GO:0051260","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0008584","count":7}]},{"hash":"834277528698167459","title":"Axon pathfinding and retina morphogenesis","description":"Most terms point to neural development and connectivity: axonal fasciculation/defasciculation, synapse assembly, cell adhesion, and retina morphogenesis, with multicellular development suggesting tissue patterning. Together these imply a cluster of proteins involved in axon guidance and retinal neurodevelopment. A single odd term about symbiont entry is likely an annotation artifact rather than a core function of the cluster.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":16},{"id":"GO:0046718","count":12},{"id":"GO:0032516","count":11},{"id":"GO:0043931","count":11},{"id":"GO:0002042","count":10}]},{"hash":"1030809380604305346","title":"Chromatin Regulation and Mitotic Cytoskeletal Machinery","description":"The top GO terms show histone acetylation (epigenetic regulation) alongside mitotic events (sister chromatid segregation, spindle assembly) and cytoskeletal processes (actin organization, cilium assembly). This suggests a shared theme around chromatin dynamics during cell division and the cytoskeleton, with a possible secondary link to RNA splicing and metal response. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":5},{"id":"GO:0043982","count":5},{"id":"GO:0060271","count":5},{"id":"GO:0043981","count":5},{"id":"GO:0051260","count":4}]},{"hash":"564433114487195402","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0003203","count":5},{"id":"GO:0003181","count":4},{"id":"GO:0003281","count":4},{"id":"GO:0003007","count":3},{"id":"GO:0006337","count":3}]},{"hash":"486109237277965759","title":"Thermogenesis and GPCR-Mediated Signaling","description":"The cluster centers on temperature-related functions (diet-induced thermogenesis, cellular response to temperature stimulus) and GPCR-activated signaling (adenylate cyclase pathways), with supporting energy production via the electron transport chain. Additional terms like pain perception, saliva secretion, and blood pressure regulation suggest broader autonomic and sensory links that can accompany thermogenic and metabolic signaling. Overall, these proteins appear to coordinate heat-induced metabolism with GPCR-driven signaling pathways.","confidence":"High","size":20,"edges":93,"triangles":128,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0042391","count":13},{"id":"GO:0010579","count":12}]},{"hash":"296656418712872391","title":"DNA replication and genome stability","description":"The top GO terms cluster around DNA replication, telomere maintenance via recombination, replication-associated repair, and DNA damage responses (cisplatin, camptothecin) along with mitotic checkpoint processes, indicating a coherent theme of replication, repair, and chromosome stability.","confidence":"High","size":20,"edges":121,"triangles":383,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0000722","count":5},{"id":"GO:0071897","count":5},{"id":"GO:0072719","count":4},{"id":"GO:1990414","count":4}]},{"hash":"137283461829297413","title":"Metanephric morphogenesis and NF-\u03baB signaling","description":"The top terms cluster around kidney tubule morphogenesis (metanephric distal/proximal tubule development), vascular/lymphatic morphogenesis and angiogenesis regulation, and robust NF-\u03baB signaling components (I-kappaB phosphorylation, NF-\u03baB activity). Additional terms point to endocytic recycling and NOD2-mediated immune signaling, suggesting a theme of developmental signaling in kidney/vasculature with concurrent immune-regulatory pathways. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072287","count":2},{"id":"GO:2001137","count":2},{"id":"GO:0036303","count":2},{"id":"GO:0072237","count":2},{"id":"GO:0070431","count":2}]},{"hash":"2276812122358299720","title":"Chloroplast energy metabolism and membrane transport","description":"These terms point to plastid/chloroplast processes: chlorophyll biosynthesis and proton-motive-force\u2013driven ATP synthesis, along with proton and ion transport and vacuolar targeting. The common thread is energy production and membrane transport within plastids and related compartments, justifying a chloroplast-focused energy/transport label.","confidence":"High","size":20,"edges":70,"triangles":60,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0015995","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0015986","count":2},{"id":"GO:0099132","count":2},{"id":"GO:0007035","count":2}]},{"hash":"319293009177535378","title":"Steroid hormone biosynthesis and P450 metabolism","description":"Most top GO terms point to steroid and lipid hormone production: androgen metabolic process, testosterone biosynthetic process, progesterone metabolic process, and prostaglandin biosynthetic process, plus omega-hydroxylase P450 pathway. This suggests proteins clustered here are enriched for steroid hormone biosynthesis and related P450-mediated metabolism. A few terms like endothelial cell\u2013cell adhesion and response to immobilization stress appear less central and may reflect broader cellular roles or annotation noise, but do not dominate the cluster.","confidence":"Medium","size":20,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":13},{"id":"GO:0061370","count":13},{"id":"GO:0001516","count":12},{"id":"GO:0097267","count":12},{"id":"GO:0033076","count":12}]},{"hash":"1605774899662608694","title":"Neuronal vesicle trafficking and synaptic plasticity","description":"The terms cluster around intracellular transport (ER-to-Golgi and endosome-to-Golgi) and neural processes (brain development, neuron projection development, long-term potentiation), suggesting proteins that mediate vesicular trafficking essential for neural maturation and synaptic function. Some motifs like ribophagy and acrosome reaction are less central but do not negate the main theme.","confidence":"Medium","size":20,"edges":152,"triangles":591,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0006886","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0045943","count":3},{"id":"GO:0034517","count":3}]},{"hash":"1920191147100256353","title":"Cardiac development and calcium signaling","description":"The enriched terms point to heart development, vascular morphogenesis, and calcium/NFAT signaling regulation, along with calcium transport, protein dephosphorylation, and exocytosis, suggesting a cohesive set of proteins involved in cardiac development and calcium-dependent signaling pathways.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0006919","count":4},{"id":"GO:0014898","count":3},{"id":"GO:0051531","count":3},{"id":"GO:0070588","count":3}]},{"hash":"1857894353883208357","title":"Rho/Rac GTPase Signaling and Cytoskeletal Dynamics","description":"These proteins are enriched for GO terms centered on small GTPase signaling (Rho/Rac), cytoskeletal remodeling (lamellipodium assembly, cell spreading), and downstream pathways (JNK regulation, apoptosis). The insulin receptor pathway and heart development terms appear as broader roles for these signaling networks, but the core unifying theme is GTPase-driven control of actin dynamics and cell adhesion, which links many of the terms in the cluster.","confidence":"High","size":20,"edges":3,"triangles":1,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":19},{"id":"GO:0008286","count":19},{"id":"GO:0007264","count":19},{"id":"GO:0032287","count":19},{"id":"GO:0035023","count":19}]},{"hash":"268677883708569291","title":"Neural development and axon guidance","description":"The dominant GO terms point to nervous system development, synapse assembly, and axonal fasciculation, with supporting roles for cell adhesion and signaling that guide neural connectivity. While there are some terms related to bone morphogenesis and ambient immune response, the strongest signal centers on neural development and synaptic/axon organization, making this label representative of the cluster\u2019s main function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0043931","count":7},{"id":"GO:0007413","count":7},{"id":"GO:0042742","count":6}]},{"hash":"2160954028828201887","title":"Mammary Epithelial Proliferation and Cell Cycle Regulation","description":"The cluster shows strong enrichment for DNA-templated transcription and multiple mitotic cell cycle transitions (G1/S, G2/M, re-entry) along with mammary gland epithelial cell proliferation, indicating a shared role in transcriptional control and cell cycle progression in mammary epithelium, with supporting signals from intracellular signal transduction and insulin signaling regulation.","confidence":"High","size":20,"edges":49,"triangles":33,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":12},{"id":"GO:0035556","count":11},{"id":"GO:0000082","count":11},{"id":"GO:0033598","count":11},{"id":"GO:0000320","count":11}]},{"hash":"684858569112837220","title":"Secretory vesicle trafficking and neurotransmitter release","description":"This cluster centers on secretory vesicle trafficking and exocytosis, with terms like presynaptic dense core vesicle exocytosis, synaptic vesicle maturation, and neurotransmitter secretion, plus SNARE regulation. Insulin secretion and glucose transport terms broaden it to endocrine secretory processes, possibly including megakaryocyte-related secretory activity.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035544","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0035855","count":3},{"id":"GO:0015758","count":3},{"id":"GO:0030073","count":3}]},{"hash":"1809550564552916473","title":"Rac GTPase signaling and cytoskeletal remodeling","description":"Based on the top GO terms, the proteins are enriched for Rac-related signaling and cytoskeletal regulation (positive regulation of GTPase activity, Rac signal transduction, stress fiber assembly, and enhanced cell spreading/adhesion). Additional terms point to membrane trafficking and stress responses, but the strongest signal is Rac-driven actin remodeling, supporting a label of Rac GTPase signaling and cytoskeletal remodeling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0016601","count":3},{"id":"GO:0043001","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0045792","count":3}]},{"hash":"1758266935554363903","title":"Cell Polarity and Actin-Mediated Trafficking","description":"This cluster centers on cell polarity, actin cytoskeleton organization, and vesicle trafficking (endocytosis and synaptic vesicle dynamics), with regulation of Rho GTPase signaling reinforcing cytoskeletal control. Although a minority of terms relate to chromatin organization, the dominant signals point to cytoskeleton-driven membrane trafficking.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071963","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006348","count":5},{"id":"GO:0006897","count":5},{"id":"GO:0051666","count":4}]},{"hash":"1378126088031872205","title":"GPCR-driven MAPK/AKT Development Signaling","description":"This cluster shows enrichment for GPCR internalization and intracellular signaling components, including positive regulation of GTPase activity and regulation of MAP kinase and protein kinase B (AKT) pathways, together with developmental processes like heart rudiment formation and intramembranous ossification, suggesting a role for GPCR-mediated signaling in developmental contexts and cell survival. The mix of signaling and developmental GO terms indicates a thematic focus on GPCR-driven signal transduction guiding development.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0001957","count":4},{"id":"GO:0043407","count":3},{"id":"GO:0032148","count":3},{"id":"GO:0043524","count":3}]},{"hash":"1072232511384765217","title":"Neural development and myelination","description":"The terms point to neural development and maturation: corpus callosum development, axonogenesis, myelination, collagen organization, and synapse assembly, plus dopamine-responsive signaling via receptor tyrosine kinases. Some immune-related terms (LPS response, dsRNA response) may reflect neural-immune interactions, but the main pattern is neural development and connectivity.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0022038","count":9},{"id":"GO:1903351","count":9},{"id":"GO:0030199","count":8},{"id":"GO:0007169","count":8},{"id":"GO:0042552","count":8}]},{"hash":"2058454420543797927","title":"GTPase-Driven Epithelial Polarity and Cytoskeleton","description":"The top terms cluster around small GTPase signaling and regulation, actin cytoskeleton remodeling (ruffles, actin branching), establishment/maintenance of epithelial polarity and tight junctions, and related signaling (ephrin). This points to a cohesive module where GTPases control epithelial polarity and dynamic cytoskeletal rearrangements.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090135","count":11},{"id":"GO:0007264","count":11},{"id":"GO:0090162","count":11},{"id":"GO:0034260","count":11},{"id":"GO:0071963","count":11}]},{"hash":"2114389807881340748","title":"Transcriptional Regulation and Chromatin Remodeling in Development","description":"The cluster is enriched for transcription-related processes (negative regulation of RNA Pol II transcription, DNA-templated transcription) and chromatin remodeling, indicating a core module of transcriptional control; the additional developmental GO terms suggest these proteins influence transcription during tissue development.","confidence":"High","size":20,"edges":110,"triangles":270,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0006351","count":10},{"id":"GO:0043044","count":10},{"id":"GO:0017055","count":9},{"id":"GO:0060534","count":9}]},{"hash":"902533652471296500","title":"Neural development and cell cycle regulation","description":"The cluster shows strong representation of neural development terms (cerebellar cortex formation, Bergmann glial cell differentiation, regulation of axon regeneration) alongside cell cycle control terms (negative regulation of cyclin-dependent protein serine/threonine kinase activity, negative regulation of cell population proliferation) and signaling pathways (insulin receptor signaling, T cell receptor signaling). This pattern suggests proteins involved in coordinating neural development with proliferative and signaling processes, hence the label.","confidence":"Medium","size":20,"edges":162,"triangles":750,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":20},{"id":"GO:0050852","count":20},{"id":"GO:2001275","count":20},{"id":"GO:0008285","count":20},{"id":"GO:0045736","count":20}]},{"hash":"999206194948738731","title":"Ubiquitin-Dependent Immune Signaling","description":"This cluster is enriched in ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, histone ubiquitination) and immune signaling pathways (TNF-mediated signaling, JNK cascade, innate immune response), suggesting a shared function in regulating immune responses through ubiquitination.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0051865","count":10},{"id":"GO:1903265","count":10},{"id":"GO:1903762","count":10},{"id":"GO:1901253","count":10}]},{"hash":"2063308524220682887","title":"Rho/Ras GTPase Signaling and Cell Migration","description":"The cluster is driven by strong signals for small GTPase pathways (Rho/Ras), cytoskeletal dynamics (lamellipodium assembly), and cell migration, suggesting a shared function in signal-regulated movement. Additional terms span developmental, immune, and neural contexts (heart development, insulin signaling, IL-4 production, B cell maturation, myelin maintenance), indicating broader tissue-wide signaling roles, but the core theme remains GTPase-mediated signaling controlling cell motility.","confidence":"Medium","size":20,"edges":20,"triangles":1,"max_degree":19,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0008286","count":13},{"id":"GO:0007264","count":13},{"id":"GO:0016477","count":13},{"id":"GO:0032287","count":13}]},{"hash":"2078518298913951065","title":"Immune Defense and Hormone Response","description":"The top GO terms show strong signals for immune functions (defense response to bacterium, inflammatory response, antimicrobial humoral response) along with steroid hormone\u2013related responses (response to 11-deoxycorticosterone, response to dehydroepiandrosterone). Although a few terms appear tangential (retina homeostasis, fertilization, lactose biosynthetic process), the dominant themes point to immune defense and hormone signaling, suggesting proteins in this cluster are connected to host defense potentially modulated by steroids.","confidence":"Medium","size":20,"edges":100,"triangles":280,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1903496","count":5},{"id":"GO:0042742","count":5},{"id":"GO:0005989","count":5},{"id":"GO:0016998","count":5},{"id":"GO:0051672","count":5}]},{"hash":"475806948980549776","title":"mRNA processing and translation initiation","description":"This cluster is dominated by GO terms related to translation initiation and formation of preinitiation complexes, as well as spliceosome-mediated mRNA processing (splicing and polyadenylation). The presence of regulatory RNA-mediated gene silencing and IRES-dependent viral translation initiation suggests broad RNA-level regulation of gene expression, combining both RNA processing/splicing and translational control. Overall, the proteins likely coordinate mRNA maturation with initiation/reinitiation of translation, including viral contexts.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":10},{"id":"GO:0001731","count":10},{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0000398","count":7}]},{"hash":"1011244023580746287","title":"Neuronal dendrite morphogenesis and Eph signaling","description":"The cluster shows a strong enrichment for neuronal development terms: dendrite development, positive regulation of dendrite morphogenesis, neuronal stem cell population maintenance, and ephrin receptor signaling pathway, all pointing to neuron differentiation and dendrite formation. Cytoskeletal regulation (pointed-end actin filament capping) further supports neurite outgrowth. A few plant-specific terms (leaf development, adaxial/abaxial pattern) appear as noise or cross-annotations, but the core signal centers on neuronal dendrite morphogenesis.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:1902213","count":6},{"id":"GO:0048366","count":6},{"id":"GO:0009955","count":6},{"id":"GO:0016358","count":6},{"id":"GO:0050775","count":6}]},{"hash":"795448885633604626","title":"Epithelial morphogenesis with inflammation and angiogenesis","description":"This cluster's GO terms point to epithelial development and remodeling (epithelial morphogenesis, negative regulation of epithelial proliferation in prostate gland development, collagen fibril organization) alongside inflammatory and vascular processes (acute-phase response, IL-8 production, nitric oxide biosynthesis, angiogenesis, regulation of platelet aggregation). The combination suggests proteins coordinating epithelial tissue remodeling with inflammatory signaling and new blood vessel formation, rather than a single, narrow pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060770","count":3},{"id":"GO:0030308","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0006953","count":3},{"id":"GO:0032757","count":3}]},{"hash":"891055037774300223","title":"Membrane remodeling and signaling in development","description":"The top GO terms cluster around membrane-related processes\u2014prospore membrane formation, phosphatidylinositol dephosphorylation, and autophagosome assembly\u2014suggesting membrane dynamics and signaling as a core theme. Developmental context is also hinted by neuron development, myelination, egg activation, and pronucleus assembly, reflecting broader roles in cellular differentiation. Thus, a label emphasizing membrane remodeling intertwined with developmental signaling seems most representative, albeit with some terms spanning different systems.","confidence":"Medium","size":20,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048666","count":3},{"id":"GO:0032366","count":3},{"id":"GO:0046716","count":3},{"id":"GO:0031642","count":2},{"id":"GO:0032120","count":2}]},{"hash":"913851926660352232","title":"Unknown","description":"The top GO terms cover immune signaling (stimulatory C-type lectin receptor signaling, Fc-gamma receptor signaling, NK cell chemotaxis), RNA processing and regulation (mRNA processing, regulation of mRNA stability, poly-ADP-ribosylation), cell cycle regulation, and various developmental processes (cerebellar granule cell differentiation, mesonephric duct development, metanephric distal tubule morphogenesis). There is no single cohesive biological theme connecting these functions, so the cluster appears to span disparate processes rather than a defined pathway or function.","confidence":"","size":20,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0002223","count":4},{"id":"GO:0070212","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0045736","count":3},{"id":"GO:0043488","count":3}]},{"hash":"2114933088110613408","title":"Cytokine repression and T cell regulation","description":"The top GO terms point to negative regulation of cytokine production (IFN, IL-4, IL-5), regulation of inflammatory response, and inhibition of T cell proliferation, with additional links to transcriptional and post-transcriptional control (RNA polymerase II activity, mRNA stability). The presence of androgen receptor signaling and environmental-stress responses (silicon dioxide, ozone) suggests broader regulatory roles in gene expression and immune modulation. Overall, these proteins likely participate in dampening immune signaling and controlling immune cell activity, hence the label.","confidence":"Medium","size":20,"edges":55,"triangles":17,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0032689","count":3},{"id":"GO:0030521","count":3},{"id":"GO:0050727","count":3},{"id":"GO:0043488","count":3},{"id":"GO:0032714","count":3}]},{"hash":"1735875397525566117","title":"Embryonic Development and Morphogenesis","description":"The top GO terms cluster around developmental processes across tissues\u2014roof of mouth development, left/right pattern formation, placenta and endocrine system development, pancreatic islet development, cartilage morphogenesis, and EMT in heart cushions\u2014pointing to a common theme of embryonic tissue formation and patterning. Despite lack of direct interactions (no edges), the annotated functions strongly align with broad developmental morphogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":9},{"id":"GO:0007275","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0060972","count":7},{"id":"GO:0060806","count":7}]},{"hash":"2087001476045883458","title":"Embryonic development and tissue morphogenesis","description":"This cluster is best described as developmental and morphogenetic because the top GO terms center on left-right patterning, placental and pancreatic development, cartilage formation, EMT in heart development, endocrine system development, and general organogenesis, with one incidental immune term. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0032496","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1346844212447993536","title":"TGF-\u03b2/BMP signaling regulation","description":"The strongest recurring terms are negative regulation of TGF-\u03b2 receptor signaling and BMP signaling, SMAD-related assembly and cellular response to TGF-\u03b2, indicating a cohesive theme of modulating TGF-\u03b2/BMP pathways. Supporting terms like peptidyl-threonine dephosphorylation reflect regulatory control of phosphorylation, and mentions of meristem identity and germ-line masculinization suggest broader developmental roles that these regulators may influence.","confidence":"High","size":20,"edges":132,"triangles":474,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0030512","count":16},{"id":"GO:0046827","count":14},{"id":"GO:0042006","count":13},{"id":"GO:0071560","count":13},{"id":"GO:0010991","count":13}]},{"hash":"1808751452955111618","title":"Developmental Signaling and Cellular Regulation","description":"This cluster highlights proteins involved in signaling and regulation across development (angiogenesis, cardiac neural crest\u2013driven heart development, visual perception) and general cellular regulation (signal transduction, spindle assembly, apoptotic signaling), with additional immune response terms (dsRNA, muramyl dipeptide). The mix suggests a core theme of development-related signaling and cell fate regulation, with supporting regulatory processes.","confidence":"Medium","size":20,"edges":134,"triangles":451,"max_degree":19,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":20},{"id":"GO:0090606","count":20},{"id":"GO:0061308","count":20},{"id":"GO:0001525","count":20},{"id":"GO:0043330","count":20}]},{"hash":"157814412266147368","title":"Embryonic patterning and organ morphogenesis","description":"The cluster centers on embryonic patterning and the morphogenesis of multiple tissues (placenta, pancreas, heart, cartilage, palate). Although some terms pertain to general gene expression (transcription/splicing), the dominant enrichment is developmental patterning and organogenesis, supporting this cohesive label.","confidence":"High","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":13},{"id":"GO:0060806","count":13},{"id":"GO:0035270","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0003323","count":13}]},{"hash":"112921206116171117","title":"Neural perception and dopaminergic reward signaling","description":"This cluster primarily centers on brain-related functions: visual and pain perception, visual learning, dopaminergic synaptic transmission, and behavioral responses to drugs like cocaine and morphine, alongside ERK1/2 signaling. These themes point to neural processing, sensation, and reward learning, with dopaminergic pathways and ERK signaling as key mechanisms, justifying the label.","confidence":"High","size":20,"edges":93,"triangles":121,"max_degree":15,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":18},{"id":"GO:0019233","count":18},{"id":"GO:0002035","count":17},{"id":"GO:0001963","count":17},{"id":"GO:0007507","count":17}]},{"hash":"145429157430699476","title":"Brain Adrenergic Signaling and Blood Pressure Regulation","description":"The top GO terms cluster around dopaminergic synaptic transmission, norepinephrine-epinephrine\u2013mediated vasoconstriction, MAPK-activating adrenergic receptor signaling, and the brain renin-angiotensin system, indicating a coherent theme of central nervous system control of cardiovascular function. Temperature-related and xenobiotic response terms may reflect broader sympathetic regulation of metabolism and stress, but the core appears to be brain adrenergic signaling governing vascular tone and blood pressure.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0042493","count":11},{"id":"GO:0007596","count":11}]},{"hash":"629612417411430768","title":"Angiogenesis and ECM remodeling during development","description":"This cluster is dominated by GO terms linked to vascular development and matrix dynamics, including angiogenesis, endothelial barrier establishment, blood coagulation, and extracellular matrix disassembly. Developmental themes are further supported by multicellular growth and amelogenesis, while digestion and neutrophil-mediated activities may reflect broader tissue remodeling and immune aspects in development. Overall, the prevailing signal points to vascular development and ECM remodeling, so this label is representative though not exclusively specific. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":10},{"id":"GO:1903142","count":10},{"id":"GO:0014068","count":10},{"id":"GO:0007596","count":10},{"id":"GO:0000122","count":10}]},{"hash":"558813760351257832","title":"Neuronal signaling and synaptic plasticity","description":"The top GO terms cluster around neural communication and sensory processing: ion transport through K+ and Na+ channels, excitatory postsynaptic potentials, GABA signaling, receptor internalization, and regulation of long-term synaptic plasticity. Additional terms reference sensory perception and neural responsiveness to electrical stimuli, supporting a theme of neuronal signaling and activity-dependent plasticity in sensory systems.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0007214","count":3},{"id":"GO:0035725","count":3}]},{"hash":"1457044055448803152","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":4},{"id":"GO:0051290","count":3},{"id":"GO:0033209","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0051092","count":2}]},{"hash":"532888396802831878","title":"Dopaminergic/Glutamatergic synaptic regulation","description":"The cluster centers on neural signaling: regulation of membrane potential, GPCR signaling, and synaptic transmission specifically involving dopamine and glutamate, with related sensory/pain modulation and sensorimotor gating (prepulse inhibition). Brain-specific pathways (renin-angiotensin system in the brain) and a neuroinflammatory signal further support a brain/neural context, all pointing to coordinated synaptic regulation in neural circuits.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":4},{"id":"GO:0045745","count":4},{"id":"GO:0006954","count":4},{"id":"GO:0051930","count":4},{"id":"GO:0060134","count":4}]},{"hash":"1226974996690432031","title":"Immune and vascular development regulation","description":"Most terms describe regulation of differentiation and morphogenesis in immune and vascular systems: plasma cell differentiation; immunoglobulin production; negative regulation of endothelial proliferation; endothelial cell morphogenesis; angiogenesis. A few terms touch neuronal/amyloid processes (negative regulation of amyloid precursor protein biosynthetic process; negative regulation of neuron projection development), but the dominant signal is modulation of immune and vascular development. With 20 proteins, the spread across immune and vascular processes suggests a cluster centered on development/regulation rather than a single pathway.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042985","count":2},{"id":"GO:0010977","count":1},{"id":"GO:0016525","count":1},{"id":"GO:0007585","count":1},{"id":"GO:0001937","count":1}]},{"hash":"843765690903860418","title":"Mitotic Cell Cycle with Transcription and Splicing","description":"The top GO terms cluster around DNA-templated transcription, mitotic cell cycle and cell division, APC/C-dependent catabolic processes, and mRNA splicing via the spliceosome, suggesting proteins involved in cell-cycle\u2013coupled transcription and RNA processing. Additional terms like cilium assembly and chromatin-related methylation hint at broader regulatory layers during division, though a few terms relate to development or stress responses, which are likely secondary associations. Overall, the core theme ties cell-cycle progression with transcriptional and splicing regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0031145","count":2}]},{"hash":"281628386516569227","title":"Ubiquitin-Mediated TNF-JNK Signaling","description":"This cluster is dominated by GO terms for ubiquitination (ubiquitin-dependent proteolysis, autoubiquitination, and specific linkage types like K63 and K6) and for signaling pathways such as TNF-mediated signaling and the JNK cascade, suggesting a cohesive role in ubiquitin-regulated signaling and protein turnover that modulates inflammatory pathways.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0046328","count":8},{"id":"GO:0033209","count":8},{"id":"GO:0051865","count":8},{"id":"GO:1903265","count":8}]},{"hash":"1835387284930314481","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2}]},{"hash":"713262076776467440","title":"Adrenergic receptor signaling and blood pressure regulation","description":"These proteins cluster around adrenergic signal transduction, with GO terms emphasizing adrenergic receptor\u2013mediated pathways (MAPK-activating and PLC-activating), and physiological effects on vasoconstriction and blood pressure, plus neural/brain components such as dopaminergic synaptic transmission and brain renin-angiotensin system. A few terms on thymocyte differentiation and neutrophil chemotaxis seem peripheral, but the dominant pattern points to catecholamine signaling and cardiovascular/brain regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":20},{"id":"GO:0001963","count":20},{"id":"GO:1900453","count":20},{"id":"GO:0001994","count":20},{"id":"GO:0071883","count":20}]},{"hash":"2143318578639458360","title":"Embryogenesis Epigenetic Regulation","description":"Dominant terms show DNA methylation-dependent heterochromatin formation, imprinting, and histone modification, all key epigenetic controls of gene expression during embryonic development. Related terms about in utero development and fertilization support a developmental context, with a few immune-related terms likely representing maternal-embryo interactions. Overall, the cluster is best described by epigenetic regulation in embryogenesis.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006346","count":4},{"id":"GO:0043966","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0070562","count":4},{"id":"GO:0045959","count":3}]},{"hash":"675355480932648619","title":"Brain adrenergic\u2013dopaminergic signaling","description":"The cluster is dominated by neural signaling terms, including brain renin-angiotensin system, dopaminergic synaptic transmission, and adrenergic receptor\u2013mediated pathways (MAPK activation, PLC signaling, and adenylate cyclase\u2013inhibiting). This points to a cohesive role in brain neurotransmission and GPCR signaling, with a few immune-related annotations likely reflecting shared components rather than a separate immune function.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"1453719248080376672","title":"Adrenergic-Dopaminergic Brain Signaling","description":"The terms cluster around neuronal signaling in the brain, notably dopaminergic synaptic transmission and adrenergic receptor\u2013mediated pathways (MAPK and PLC activation), plus norepinephrine/epinephrine\u2013driven vasoconstriction and modulation of synaptic plasticity. These together point to a coherent theme of brain adrenergic-dopaminergic signaling affecting neural communication and vascular regulation.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"634080162635672102","title":"Collagen ECM and Bone Development","description":"The top GO terms cluster around collagen fibril organization and biosynthesis, plus bone-related processes like intramembranous ossification, bone development, and cartilage condensation, indicating a collagen-rich extracellular matrix role in skeletal/tissue development. Additional terms related to skin development and angiogenesis remodeling fit the connective tissue remodeling theme. Overall, these proteins likely function together in ECM production and skeletal tissue formation, with related connective tissue processes reflected.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":6},{"id":"GO:0016525","count":5},{"id":"GO:0051965","count":4},{"id":"GO:0032964","count":4},{"id":"GO:0051901","count":3}]},{"hash":"1888622741040497561","title":"Inflammation and vascular regulation","description":"Top GO terms point to inflammatory processes (inflammatory response, response to lipopolysaccharide) and immune signaling, along with regulation of vascular tone (vasoconstriction, blood pressure, smooth muscle contraction) and related GPCR/Rho signaling. While energy metabolism (electron transport chain) appears, the dominant theme across the cluster is inflammation-linked cardiovascular regulation, suggesting a set of proteins involved in immune-vascular cross-talk.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0022900","count":18},{"id":"GO:0006954","count":18},{"id":"GO:0045986","count":18},{"id":"GO:0010579","count":18}]},{"hash":"897762556316970588","title":"Cardiovascular Integrin\u2013Rho\u2013PI3K signaling","description":"The enriched terms point to integrin activation, Rho signaling, and PI3K/AKT pathways together with heart development and platelet activation, suggesting a signaling module governing adhesion, cytoskeletal remodeling, and cardiovascular/platelet function.","confidence":"High","size":19,"edges":27,"triangles":6,"max_degree":16,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0008344","count":15},{"id":"GO:0090630","count":15},{"id":"GO:0033622","count":15},{"id":"GO:0043491","count":15},{"id":"GO:0010765","count":15}]},{"hash":"1400438004898464456","title":"Nucleotide catabolism and pollen development","description":"The cluster is dominated by several nucleotide catabolic processes (UDP, ADP, GDP, CDP catabolic) suggesting a shared role in nucleotide turnover/metabolism. At the same time, GO terms for pollen exine formation and anther dehiscence indicate a plant-reproductive development theme, with supporting cellular-process terms like actin filament dynamics and mitochondrial inheritance. This combination points to a cluster that links nucleotide metabolism with pollen development functions, hence the label.","confidence":"Medium","size":19,"edges":155,"triangles":733,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006256","count":10},{"id":"GO:0071405","count":10},{"id":"GO:0010584","count":10},{"id":"GO:0006487","count":10},{"id":"GO:0046032","count":10}]},{"hash":"877631877930958618","title":"COPII vesicle trafficking and mitotic development","description":"The cluster is dominated by GO terms for COPII-coated vesicle budding and ER-Golgi transport, alongside mitotic cell cycle, cell division, and spindle assembly, with additional signals for growth and brain development. This points to proteins that coordinate secretory pathway trafficking with cell division processes during development, including neural tissues. ","confidence":"Medium","size":19,"edges":28,"triangles":3,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090114","count":13},{"id":"GO:0000278","count":12},{"id":"GO:0051301","count":12},{"id":"GO:0006890","count":12},{"id":"GO:0090307","count":12}]},{"hash":"750352921156033333","title":"Embryonic organ development and tissue differentiation","description":"The terms cluster around broad embryonic development across multiple organs (neural crest, pancreas, kidney, digestive tract, pituitary, hypothalamus, inner ear, habenula) and related differentiation processes, with one regulatory term (negative regulation of transcription) that fits into developmental control. This pattern points to a general developmental program rather than a single pathway.","confidence":"High","size":19,"edges":9,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":8},{"id":"GO:0031018","count":7},{"id":"GO:0001755","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0048557","count":7}]},{"hash":"202076558629450419","title":"Mitochondrial Transport and Membrane Remodeling","description":"The dominant GO terms point to transport of diverse metabolites across membranes (NAD, glycine, ornithine, deoxynucleotides, thiamine pyrophosphate) and to mitochondrial membrane dynamics (fission and permeability regulation). Together, these imply a cohesive role for this cluster in mitochondrial metabolite import and in maintaining mitochondrial membrane integrity, with auxiliary links to nutrient stress responses and tissue regeneration contexts.","confidence":"High","size":19,"edges":24,"triangles":1,"max_degree":7,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0034198","count":9},{"id":"GO:0035352","count":7},{"id":"GO:0000066","count":7},{"id":"GO:0097421","count":7},{"id":"GO:0036233","count":7}]},{"hash":"1977375685398508638","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":149,"triangles":672,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0034476","count":11},{"id":"GO:1903608","count":11},{"id":"GO:0006306","count":11}]},{"hash":"1713277071878633125","title":"Ribosome biogenesis and translation machinery","description":"The top GO terms are dominated by translation processes (initiation, elongation, termination, cytoplasmic translation) and ribosome biogenesis, with selenocysteine incorporation linking to the translation system; these point to a core theme of ribosome production and protein synthesis. Some outliers like response to antibiotic and glial cell proliferation exist, but the strong, central signal is translation machinery. ","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0045901","count":5},{"id":"GO:0006413","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0014009","count":5}]},{"hash":"1894927595394688148","title":"Cardiac morphogenesis and mechanotransduction","description":"The cluster is dominated by GO terms tied to heart development and morphogenesis (heart development, cardiac right atrium morphogenesis, Notch signaling in heart field regulation, animal organ development) and cellular responses to mechanical stimuli, suggesting a core theme of cardiac formation and mechano-sensing. The presence of spermatid nucleus differentiation and spindle assembly terms likely reflects shared cell-cycle components or annotation noise rather than a unifying function, but does not override the cardiac-focused signal.","confidence":"Medium","size":19,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007289","count":6},{"id":"GO:0051225","count":6},{"id":"GO:0097190","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0009408","count":5}]},{"hash":"831759001017966206","title":"Embryonic Development and Organogenesis","description":"The top GO terms indicate broad developmental roles across multiple tissues (mammary gland, thymus, heart, floor plate, lung, retina) and embryonic processes (in utero development, somitogenesis, organ formation), with general transcriptional regulation also highlighted. This suggests the cluster is centered on embryonic development and organogenesis rather than a single tissue-specific function.","confidence":"High","size":19,"edges":148,"triangles":693,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0061030","count":16},{"id":"GO:0033092","count":16},{"id":"GO:0001701","count":16},{"id":"GO:0042593","count":15},{"id":"GO:0003208","count":15}]},{"hash":"48889907236135034","title":"Wnt-Polarity Signaling and Ubiquitination","description":"The cluster centers on epithelial cell polarity and Wnt signaling, with strong hints of protein ubiquitination/ERAD, and includes signatures of ER stress\u2013mediated apoptosis, growth/development signals, telomere maintenance, and immune signaling. This combination suggests a theme around signaling pathways that govern polarity, development, and cellular stress responses, rather than a single narrow function. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0090162","count":6},{"id":"GO:0016055","count":6},{"id":"GO:0016567","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0050830","count":6}]},{"hash":"1062228866885080052","title":"Mitotic Progression and Ubiquitin-Proteasome Degradation","description":"The cluster is dominated by mitosis- and cell-cycle-related GO terms: exit from mitosis, G2/M transition, mitotic cell cycle, and chromosome segregation, plus heavy involvement of ubiquitin-proteasome\u2013mediated processes (SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein autoubiquitination, ERAD). Additional terms for chromatin organization and nucleotide-excision repair align with chromosomal remodeling and genome maintenance during division. The viral process term may reflect incidental associations but does not override the core theme of mitotic regulation via ubiquitin-proteasome pathways.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0010458","count":19},{"id":"GO:0031146","count":19},{"id":"GO:0070911","count":19},{"id":"GO:0000086","count":19},{"id":"GO:0007059","count":19}]},{"hash":"699754886835821756","title":"Developmental cell fate specification","description":"The top GO terms cluster around specifying cell fates during development across multiple tissues (neural lineages, pancreas, bronchioles), all tied together by transcriptional regulation, suggesting a group of proteins involved in embryonic differentiation programs.","confidence":"High","size":19,"edges":162,"triangles":833,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0031018","count":14},{"id":"GO:0060163","count":14},{"id":"GO:0021530","count":14},{"id":"GO:0060435","count":14},{"id":"GO:0006366","count":14}]},{"hash":"1452751955032082026","title":"Neural and sensory development","description":"This cluster is dominated by neural- and sensory-related terms: midbrain development, brain development, inner ear development, and visual perception appear with several proteins, indicating a core theme of nervous system and sensory maturation. While there are a few non-neural terms (e.g., regulation of transcription and immune response) they are less central to the majority of terms, supporting the neural/sensory development framing.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:1903142","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0050830","count":4},{"id":"GO:0044130","count":4}]},{"hash":"2066847538211230166","title":"Angiogenesis and ECM remodeling","description":"This cluster is dominated by GO terms related to blood vessel formation (positive regulation of angiogenesis, endothelial barrier establishment) and extracellular matrix remodeling (extracellular matrix disassembly), along with broader tissue growth terms. While there are a couple of immune defense terms and digestion-related terms present, the core signal points to vascular development and matrix remodeling during tissue growth or repair. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":5},{"id":"GO:0050830","count":5},{"id":"GO:1903142","count":5},{"id":"GO:0071333","count":5},{"id":"GO:0014068","count":5}]},{"hash":"2221604731944826789","title":"Diverse metabolite biosynthesis","description":"This cluster contains several biosynthetic processes (menaquinone, biotin, antibiotic, strigolactone), suggesting a theme around small-molecule production. However, there are also catabolic and degradative terms (phenylpropionate and 1,2-dichloroethane catabolism) and proteolysis, indicating broader metabolic roles. The strongest, cohesive signal is biosynthesis of diverse metabolites.","confidence":"Medium","size":19,"edges":32,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":5},{"id":"GO:0017000","count":4},{"id":"GO:0006508","count":3},{"id":"GO:0019380","count":3},{"id":"GO:0055114","count":3}]},{"hash":"1978910179375214644","title":"Keratinocyte differentiation and growth signaling","description":"The top GO terms center on epidermal differentiation (keratinocytes) and core growth-regulatory pathways (Hippo signaling and canonical Wnt signaling), with related processes in apoptosis and DNA replication indicating coordinated control of cell proliferation and fate in skin tissue. Some obsolete terms appear, but the dominant theme is epidermal differentiation coupled with growth regulation.","confidence":"High","size":19,"edges":129,"triangles":438,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030216","count":18},{"id":"GO:0060044","count":18},{"id":"GO:0035329","count":18},{"id":"GO:0006915","count":18},{"id":"GO:0090263","count":18}]},{"hash":"1964322948083315583","title":"Adrenergic and dopaminergic neural signaling","description":"The cluster is dominated by GO terms for dopaminergic synaptic transmission, adrenergic receptor\u2013mediated signaling, and related autonomic functions (vasoconstriction, blood pressure regulation, MAPK pathway activation). Additional terms about membrane potential regulation and temperature-related responses fit with sympathetic/metabolic control. The DN2 thymocyte differentiation term is an outlier, but the core pattern points to neural/autonomic signaling and thermoregulation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":17},{"id":"GO:0002024","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0002035","count":16}]},{"hash":"1041799233097359077","title":"Neural development and synaptic signaling","description":"This cluster shows several neural-focused GO terms: calcium ion transmembrane transport, long-term synaptic potentiation, positive regulation of dendritic spine morphogenesis, cellular responses related to neural activity (exploration behavior), and GPCR catabolic processes, suggesting a theme around neuronal development and synaptic signaling. Some terms (heart development, eye morphogenesis) are developmental but not obviously neural, so the dominant signal points to neural processes overall.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006470","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1810091016998202641","title":"Unknown","description":"The top GO terms cover very diverse processes (mRNA splicing, calcium signaling, protein self-assembly, taste perception, mitotic cell cycle, immune defense, and phagolysosome assembly) with no clear shared function or pathway, and there are no edges linking the proteins, suggesting no cohesive theme. Obsolete acetylation terms further indicate noisy or reconciled annotations rather than a single module. Consequently, there is no reliable single function characterizing this cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0051209","count":3},{"id":"GO:0098703","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0050909","count":2}]},{"hash":"628604920523164162","title":"MAPK Signaling in Neuronal Morphogenesis","description":"MAPK signaling terms dominate (ERK cascade, positive regulation of axon extension, dendrite morphogenesis) with supporting cytoskeletal and PI3K activity terms, pointing to proteins coordinating neurite growth and structural remodeling. A few immune signaling terms appear, but the core theme is neuronal morphogenesis governed by MAPK/related pathways. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045773","count":16},{"id":"GO:0050852","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0000278","count":16},{"id":"GO:0033138","count":16}]},{"hash":"1576009475475286225","title":"Ribosome biogenesis and RNA processing","description":"The top terms show a clear enrichment for RNA processing (mRNA splicing via spliceosome, regulatory ncRNA-mediated gene silencing, mRNA polyadenylation) and RNA maturation, together with ribosome biogenesis (formation and maturation of rRNA, ribosomal subunit biogenesis) and translation initiation/reinitiation. This suggests a cluster of proteins involved in nuclear RNA processing and ribosome assembly/translation initiation. High","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":7},{"id":"GO:0000398","count":7},{"id":"GO:0001731","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7}]},{"hash":"1838665470252350315","title":"Immune Signaling and Phagocytosis","description":"The top GO terms point to coordinated innate and adaptive immune functions: phagocytosis recognition and engulfment, innate immune response, complement activation, B cell activation and BCR signaling, T cell costimulation, NK cell regulation, and interleukin-2 production. This pattern suggests a cluster of proteins involved in immune cell communication, activation, and phagocytic processes across multiple immune lineages. ","confidence":"High","size":19,"edges":135,"triangles":475,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006910","count":10},{"id":"GO:0050871","count":9},{"id":"GO:0045087","count":9},{"id":"GO:0006958","count":9},{"id":"GO:0050853","count":9}]},{"hash":"2201872730483699912","title":"Bacterial lipid metabolism and menaquinone biosynthesis","description":"The top GO terms cluster around biosynthesis and metabolism of lipids and quinones: menaquinone biosynthetic process, lipoteichoic acid biosynthesis, fatty acid biosynthetic and long-chain fatty acid metabolic processes, and fatty acid import. These point to a cohesive theme of lipid assembly and energy-related cofactors in bacteria (with lipoteichoic acid reflecting Gram-positive envelope components). A few catabolic terms appear but do not override the lipid-centric pattern, though bioluminescence is an outlier term present in the set. Overall, the cluster is best described by lipid biosynthesis and related energy metabolism in bacteria.","confidence":"High","size":19,"edges":86,"triangles":144,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":9},{"id":"GO:0070395","count":8},{"id":"GO:0090410","count":7},{"id":"GO:0006633","count":7},{"id":"GO:0001676","count":7}]},{"hash":"485531715918530588","title":"Neural development and axon growth","description":"The cluster is dominated by GO terms related to neural and nervous system development, including neuron development, nervous system development, peripheral nervous system development, and positive regulation of axon extension, along with signals like the smoothened (hedgehog) pathway and dendritic spine development. While organ-development terms (lung, kidney) appear, the strongest and most frequent terms point to neural development and axon growth as the core theme, suggesting these proteins function together in neural development signaling and axon guidance.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060999","count":4},{"id":"GO:0048666","count":3},{"id":"GO:0007422","count":3},{"id":"GO:0042503","count":3},{"id":"GO:0030324","count":3}]},{"hash":"60465629546273956","title":"Neural development and inflammatory signaling","description":"The cluster shows strong representation of nervous system development terms (nervous system development, cerebral cortex development, neuron projection development) alongside inflammatory signaling terms (positive regulation of cytokine production in inflammatory response, interleukin-1 beta production, NF-kappaB transcription factor activity). This combination suggests proteins involved in neural development that also participate in inflammatory pathways, with some broader developmental roles such as morphogenesis terms. Overall, the neural development theme with inflammatory signaling best captures the core pattern in the Top Terms.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900017","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0051260","count":2},{"id":"GO:0050702","count":2},{"id":"GO:0001783","count":2}]},{"hash":"1800295241627981365","title":"Dopaminergic signaling and drug-response neural functions","description":"The cluster is dominated by GO terms for dopaminergic synaptic transmission, addiction-related behavioral responses (cocaine, morphine), and ERK-mediated plasticity, with supporting visual perception and learning terms. This suggests a neural signaling module centered on dopamine pathways and drug-induced plasticity; a few terms like heart development may be outliers.","confidence":"High","size":19,"edges":142,"triangles":593,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":17},{"id":"GO:0007601","count":16},{"id":"GO:0070374","count":16},{"id":"GO:0001963","count":16},{"id":"GO:0048148","count":16}]},{"hash":"924046495796038046","title":"Immune and apoptotic stress response","description":"Most enriched terms cluster around innate immune and stress responses and apoptosis (cellular response to lipopolysaccharide, response to virus, apoptotic processes, extrinsic apoptotic signaling), with oxidative stress and xenobiotic response also represented. ER-Golgi transport can be involved in stress-related protein handling, and circadian regulation can intersect immune responses. Eye/epidermis development terms are less central, possibly reflecting tissue contexts rather than core function. Overall, the cluster appears to represent immune- and apoptosis-related stress responses.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0001654","count":3},{"id":"GO:0008544","count":3}]},{"hash":"1903460015857949000","title":"Growth signaling and genome maintenance","description":"The top terms revolve around TORC1 signaling and nutrient response, which tie to growth control, and are complemented by cell cycle regulation, DNA repair, and chromatin-related transcription factors. Developmental growth terms and multicellular growth hint at tissue-level regulation, but the common thread is coordinating growth signals with transcriptional and genome integrity pathways. Confidence: Medium","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0038202","count":4},{"id":"GO:0021510","count":4},{"id":"GO:0007584","count":4},{"id":"GO:0051567","count":4},{"id":"GO:0000724","count":4}]},{"hash":"475584544593018556","title":"Immune cell adhesion and cytotoxic regulation","description":"This cluster is driven by GO terms describing cell-cell adhesion (homophilic/heterophilic), synapse organization, and actin cytoskeleton regulation by adhesion, plus immune-regulatory processes such as negative regulation of NK and cytotoxic T cell activities and phagocytosis recognition, indicating a cohesive theme of immune cell interactions and cytoskeletal\u2013adhesion dynamics.","confidence":"High","size":19,"edges":97,"triangles":163,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":10},{"id":"GO:0090138","count":10},{"id":"GO:0086072","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0043031","count":10}]},{"hash":"812557953998562470","title":"Mitochondrial energy metabolism","description":"Based on GO terms for glycolysis, pyruvate decarboxylation to acetyl-CoA, the TCA cycle, and assembly of the mitochondrial respiratory chain, the cluster is best described as proteins involved in mitochondrial energy production and central carbon metabolism. A translation term appears but is not the dominant theme.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0055114","count":2},{"id":"GO:0032981","count":2},{"id":"GO:0033512","count":1},{"id":"GO:0043617","count":1}]},{"hash":"794952486360972530","title":"Unknown","description":"The Top Terms cover metabolic biosynthesis (thiamine, PQQ) and nucleotide modification (tRNA methylation) alongside diverse signaling and development terms (NF-kappaB, corticosterone response, heart development) and cell cycle regulation. This broad mix lacks a single cohesive biological theme, so a precise, intuitive label isn\u2019t justifiable.","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0018189","count":3},{"id":"GO:0009228","count":3},{"id":"GO:0030488","count":3}]},{"hash":"1904100442985784959","title":"Organelle Translation and Energy Metabolism","description":"The dominant GO terms cluster around translation-related processes (translation, ribosomal subunit assembly, mitochondrial translation) and energy metabolism pathways (mitochondrial electron transport NADH to ubiquinone, proton motive force-driven ATP synthesis, photosynthesis light reaction), plus membrane transport and targeting. This combination suggests a cohesive theme of organelle-level protein synthesis coordinated with energy production in chloroplasts and mitochondria, with transport-related processes supporting these functions.","confidence":"High","size":19,"edges":125,"triangles":502,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0042777","count":3},{"id":"GO:0099132","count":3},{"id":"GO:0071353","count":2},{"id":"GO:0000027","count":2}]},{"hash":"1086614363951231812","title":"Keratinization and cytoskeletal remodeling","description":"The dominant GO term is keratinization (12), pointing to epidermal differentiation and keratin filament involvement. Additionally, actin crosslink formation and positive regulation of GTPase activity indicate cytoskeletal remodeling, supporting a theme of structural cellular organization. Some terms (heart development, hepatocyte dedifferentiation, synaptic potentiation) seem less connected and may reflect broader or pleiotropic annotations, but the strongest signal is keratinization with cytoskeletal dynamics.","confidence":"Medium","size":19,"edges":51,"triangles":69,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":12},{"id":"GO:0071732","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1716580298128626075","title":"Triglyceride Catabolism and Lipid Remodeling","description":"This cluster is dominated by triglyceride-related GO terms (triglyceride catabolic process, triglyceride mobilization, positive/negative regulation of triglyceride catabolic process, triglyceride acyl-chain remodeling) and phospholipid catabolism (phosphatidylethanolamine and phosphatidylcholine). These point to a cohesive lipid metabolism role, with a few auxiliary terms touching signaling and immune processes, but the lipid catabolism/remodeling theme is strongest. ","confidence":"High","size":19,"edges":76,"triangles":47,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":7},{"id":"GO:0010898","count":7},{"id":"GO:0036153","count":7},{"id":"GO:2000480","count":7},{"id":"GO:0046338","count":7}]},{"hash":"1813324224252872312","title":"Embryonic organ morphogenesis (kidney, cartilage, lymphatics)","description":"The top GO terms point to organogenesis across multiple tissues (kidney development, cartilage condensation, lymph vessel morphogenesis), indicating a cluster of proteins involved in embryonic tissue patterning. Immune signaling terms appear but are less central to a single pathway, so the core theme is developmental morphogenesis across organs.","confidence":"Medium","size":19,"edges":160,"triangles":808,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":19},{"id":"GO:0001867","count":19},{"id":"GO:0060355","count":19},{"id":"GO:0051873","count":19},{"id":"GO:0072177","count":18}]},{"hash":"682708599758240447","title":"Bacterial quinone and fatty acid metabolism","description":"The cluster shows strong enrichment for quinone biosynthesis (menaquinone, phylloquinone) and fatty acid beta-oxidation, with supporting catabolic processes for valine and phenylacetate and some antibiotic biosynthesis signals. This points to a cohesive bacterial metabolic module centered on lipid-derived cofactor production and energy-yielding pathways, with minor hints of secondary metabolism; peroxisome-related terms are less dominant. ","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":19},{"id":"GO:0006574","count":19},{"id":"GO:0010124","count":19},{"id":"GO:0006635","count":19},{"id":"GO:0009234","count":19}]},{"hash":"1115477937331033351","title":"Cholinergic Neuromuscular Signaling and Locomotion","description":"This cluster is driven by neuromuscular and movement-related GO terms, notably neuromuscular process controlling posture, cholinergic synaptic transmission, and locomotory behavior, indicating proteins involved in neuromuscular signaling that regulate movement. Some terms are regulatory or unrelated, but the strongest cohesive signal points to cholinergic neuromuscular signaling and locomotion control.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":5},{"id":"GO:0035634","count":4},{"id":"GO:0032429","count":4},{"id":"GO:0030336","count":4},{"id":"GO:2001268","count":4}]},{"hash":"1693510694853933245","title":"Immune signaling and cytokine regulation","description":"This cluster is enriched for immune-related processes: NK cell regulation, B cell activation, IL-2 production, cytokine production, NK cell tolerance, T cell activation regulation, and interferon production, plus innate sensing of peptidoglycan. These together point to a coherent theme of immune activation and cytokine signaling, with a couple outliers (neuronal axon guidance and cardiac depolarization) that are less represented. Confidence: High","confidence":"","size":19,"edges":29,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":3},{"id":"GO:0050871","count":3},{"id":"GO:1900042","count":3},{"id":"GO:0032499","count":3},{"id":"GO:0060371","count":3}]},{"hash":"973342384859334676","title":"Negative Regulation of Signaling Pathways","description":"The cluster is enriched for GO terms describing negative regulation of signaling cascades (e.g., ERK/MAPK, T cell receptor, interferon signaling), suggesting these proteins tend to dampen signaling. Additional terms point to neural development and cell-adhesion contexts (vestibular receptor morphogenesis, Slit diaphragm assembly, oligodendrocyte progenitor proliferation, integrin-mediated adhesion), supporting a broader theme of downregulation in immune and neural development pathways.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":18},{"id":"GO:0070373","count":18},{"id":"GO:0050860","count":18},{"id":"GO:0060116","count":13},{"id":"GO:0060336","count":13}]},{"hash":"2159622200205783691","title":"Vertebrate Development and Organogenesis","description":"The cluster centers on multiple tissue- and organ-specific developmental processes (retina, osteoblast, palate, brain segmentation, rhombomere development, endocrine pancreas) and a general transcriptional framework, indicating these proteins collectively participate in vertebrate embryonic development and organ formation rather than a single specific pathway.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":10},{"id":"GO:0002087","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0002076","count":9},{"id":"GO:0060021","count":6}]},{"hash":"1038333069477169261","title":"Ubiquitin-Proteasome Degradation and Cell Cycle Control","description":"The cluster is dominated by ubiquitin-dependent protein catabolic processes (GO:0042787; GO:0031146) indicating proteasomal degradation via the ubiquitin pathway. Several terms point to cell cycle regulation and DNA replication initiation (regulation of circadian rhythm, mitotic G1 DNA damage checkpoint signaling, regulation of DNA-templated DNA replication initiation), suggesting a theme of coordinated protein turnover with cell cycle control. Additional terms related to stress responses and neural development appear as secondary associations. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0031146","count":6},{"id":"GO:0042752","count":5},{"id":"GO:0000083","count":4},{"id":"GO:1903378","count":4}]},{"hash":"1800329700896624731","title":"Ubiquitin-Dependent Regulation of Tissue Development","description":"The majority of terms point to ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process; negative regulation of ubiquitination; specific ubiquitin linkage) with additional links to development in skeletal muscle and immune tissues (muscle development, germinal center formation, B cell signaling). This suggests a cohesive theme around ubiquitin-regulated signaling affecting tissue development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":14},{"id":"GO:0042752","count":11},{"id":"GO:0048741","count":8},{"id":"GO:2000312","count":7},{"id":"GO:0007519","count":7}]},{"hash":"1750251815860673371","title":"Cytoskeleton Remodeling and Cell Migration","description":"The top GO terms point to cytoskeletal dynamics\u2014cell migration, actin filament bundle assembly, spindle assembly, and centrosome cycle\u2014indicating a focus on cytoskeleton remodeling and movement; other terms may reflect ancillary signaling or maintenance roles.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":3},{"id":"GO:0007098","count":3},{"id":"GO:0007205","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0051225","count":3}]},{"hash":"2098028925130403361","title":"Blood coagulation and complement activation with ECM remodeling","description":"The cluster shows strong enrichment for blood coagulation and complement activation terms (classical and lectin pathways), indicating a hemostasis/innate immunity theme. Additional terms point to extracellular matrix remodeling (collagen catabolic process, biomineral tissue development) and developmental signaling (Wnt pathway, midbrain development), suggesting these proteins may participate in coordinated coagulation, immune response, and tissue remodeling or development. The transcription regulation term appears less connected to the core theme, possibly reflecting regulatory proteins within the set. Overall, coagulation plus ECM remodeling provides the most coherent label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":8},{"id":"GO:0006958","count":8},{"id":"GO:0000122","count":8},{"id":"GO:0001867","count":7},{"id":"GO:0030574","count":7}]},{"hash":"1744708833981170900","title":"Multi-tissue differentiation","description":"The top GO terms cover differentiation across many tissues (lens fiber cells, fat, cartilage/chondroblasts, pancreatic cells, mesoderm, roof of the mouth) and developmental growth/regulation, suggesting these proteins participate in broad developmental differentiation programs rather than a single pathway.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070306","count":6},{"id":"GO:0050680","count":5},{"id":"GO:0000122","count":5},{"id":"GO:0035264","count":5},{"id":"GO:0007498","count":4}]},{"hash":"2204826780735359671","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0000472","count":3},{"id":"GO:1903546","count":2},{"id":"GO:0001843","count":2}]},{"hash":"524476372178766993","title":"Embryonic organogenesis and patterning","description":"This cluster aggregates genes tied to developmental patterning and organogenesis across several lineages (heart development, pancreatic endocrine cell development, placenta/trophoblast differentiation, and left-right patterning). The inclusion of neurotransmitter secretion and spliceosome/transcription regulation terms suggests these proteins include tissue-specific differentiation factors and general gene-expression controls active during development. Overall, the common theme is embryonic organogenesis and patterning.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007269","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0014898","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0000398","count":3}]},{"hash":"1519033326063166950","title":"Adrenergic GPCR Signaling and Calcium Release","description":"The top GO terms point to adrenergic receptor signaling activated via GPCRs, including calcium release into the cytosol and PLC/MAPK pathways, with links to dopaminergic synaptic transmission and blood pressure regulation. This suggests a cohesive theme of GPCR-driven signaling governing neuronal and vascular responses, centered on calcium mobilization and MAPK signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051209","count":17},{"id":"GO:0035625","count":17},{"id":"GO:0002035","count":16},{"id":"GO:0001963","count":16},{"id":"GO:1900453","count":16}]},{"hash":"706346420422835308","title":"RNAP II transcription regulation and chromatin localization","description":"The top GO terms cluster around RNA polymerase II\u2013mediated transcription, including preinitiation complex assembly and both positive and negative regulation of transcription, as well as establishment of protein localization to chromatin. This points to a core function in nuclear transcription control and chromatin-associated processes, with supporting signals from related development and replication terms. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":3},{"id":"GO:0051123","count":2},{"id":"GO:0001649","count":2},{"id":"GO:0071169","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1209402325995660113","title":"Adrenergic and Dopaminergic Neuronal Signaling","description":"The cluster centers on brain adrenergic signaling and dopaminergic synaptic transmission, including norepinephrine/epinephrine\u2013driven vasoconstriction, MAPK- and PLC-mediated adrenergic pathways, and dopaminergic signaling. While a couple terms touch immune differentiation or chemotaxis, the dominant pattern is neuronal adrenergic/dopaminergic signaling, suggesting a cohesive functional theme.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":19},{"id":"GO:0001963","count":19},{"id":"GO:1900453","count":19},{"id":"GO:0001994","count":19},{"id":"GO:0071883","count":19}]},{"hash":"1913881463667055000","title":"Embryogenesis and organ morphogenesis","description":"The top GO terms cluster around embryonic development and tissue/organ morphogenesis\u2014left-right patterning, mesoderm formation, palate development, hair follicle morphogenesis, cartilage development, endocrine system development, and placental differentiation. The broad, cross-tissue developmental theme without specific pathway signals supports a label centered on embryogenesis and organ morphogenesis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":19},{"id":"GO:0060707","count":19},{"id":"GO:0060806","count":19},{"id":"GO:0035270","count":19},{"id":"GO:0003323","count":19}]},{"hash":"1134277657252064530","title":"Actin-driven muscle and heart development","description":"The terms show a clear emphasis on actin cytoskeleton organization, including muscle thin filament assembly and actin filament branching, plus heart development and postsynaptic density assembly. This points to actin-based structural remodeling underlying muscle formation and cardiac development, with supporting terms in synaptic assembly and developmental signaling (e.g., TGFB). Other items (IL-2 production, yeast response) are more peripheral and likely reflect broader signaling contexts rather than a single cohesive function. Overall, the cluster appears to center on actin-driven structural processes in muscle/heart and related cellular architectures.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071689","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0071560","count":2},{"id":"GO:1904424","count":2},{"id":"GO:0035156","count":2}]},{"hash":"1111992762929183045","title":"ER-Golgi Trafficking and Cell Cycle Control","description":"This cluster centers on ER-to-Golgi vesicle transport and protein quality control (ERAD), plus serine dephosphorylation and cell cycle regulation (mitotic cell cycle, checkpoint). Chromatin organization and histone acetylation terms add a nuclear layer that can connect to cell cycle\u2013linked chromatin remodeling, suggesting a broader role in coordinated protein processing and cell proliferation. Some terms (e.g., taste perception, obsolete annotations) may be noise. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0070262","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0030433","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0071560","count":3}]},{"hash":"165283610306396251","title":"Unknown","description":"The top terms are scattered across skin keratinization, ear nerve function (sound perception, myelination, axon growth), mitochondrial protein trafficking, transcription, immune signaling, and muscle assembly, with no clear common biological process linking them. Therefore there is no cohesive label that accurately represents the cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0045773","count":2}]},{"hash":"1107693371028587556","title":"GPCR-Driven Neurovascular Signaling and Inflammation","description":"The prominent GO terms center on GPCR signaling that activates adenylate cyclase, neuropeptide signaling, vascular tone control (vasoconstriction, smooth muscle regulation, blood pressure), and inflammatory responses (coagulation, LPS response, pain). This suggests a cohesive GPCR-mediated neurovascular/inflammatory module, with metabolic context hinted by the electron transport chain.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0019233","count":17},{"id":"GO:0035025","count":17},{"id":"GO:0045777","count":17}]},{"hash":"2058681927866485368","title":"Unknown","description":"The proteins map to a broad mix of GO terms (mitotic cell cycle, ubiquitin regulation, transcription, innate immunity, host interaction, and trafficking) with no dominant shared function, and no edges connecting them, so there is no clear functional theme to name the cluster.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:1904667","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045087","count":2}]},{"hash":"1968034019822600861","title":"Drosophila planar polarity and wing morphogenesis","description":"Several dominant GO terms point to planar polarity and wing development in Drosophila: establishment of imaginal disc-derived wing hair orientation, protein localization involved in planar polarity, and head morphogenesis, together with Wnt signaling. While terms like phototaxis and memory appear, the cohesive thread is polarity-directed development focusing on wing morphogenesis and related embryonic patterning. This suggests a cluster centered on planar polarity and wing morphogenesis in fruit flies.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042331","count":1},{"id":"GO:0001737","count":1},{"id":"GO:0002003","count":1},{"id":"GO:0048069","count":1},{"id":"GO:0007614","count":1}]},{"hash":"1652021348013237683","title":"Neuronal development and synapse formation","description":"The top terms are dominated by neural processes\u2014neuron projection development, axonal fasciculation, and positive regulation of synapse assembly\u2014suggesting this cluster centers on shaping neuronal connections and synapse formation. While a few terms refer to immune or non-neural development, the neural signals are clearly predominant.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048671","count":5},{"id":"GO:0007413","count":5},{"id":"GO:0051965","count":5},{"id":"GO:0050830","count":3},{"id":"GO:0031175","count":3}]},{"hash":"931143856689280374","title":"Neural development and signaling","description":"The GO terms show a clear emphasis on nervous system-related processes\u2014axonogenesis, Schwann cell development, visual perception, and excitatory synaptic activity\u2014suggesting proteins functioning in neural development and neuronal signaling. While terms like mitotic cell cycle and heart development are broader, they do not override the dominant neural theme across the cluster.","confidence":"Medium","size":18,"edges":135,"triangles":651,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":16},{"id":"GO:0007507","count":16},{"id":"GO:0043065","count":16},{"id":"GO:0007601","count":16},{"id":"GO:0000086","count":16}]},{"hash":"1246338888379976805","title":"GPCR Endocytosis and Cell Migration","description":"The top GO terms point to clathrin-dependent endocytosis and GPCR internalization, alongside cell migration, indicating a cluster of proteins involved in GPCR trafficking at the membrane and regulation of cell movement. Some additional terms touch on muscle signaling and metabolism, likely reflecting connected signaling pathways in muscle or migratory cells, but the core theme is membrane trafficking and migration. ","confidence":"Medium","size":18,"edges":18,"triangles":1,"max_degree":17,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0060048","count":16},{"id":"GO:0016477","count":15},{"id":"GO:0072583","count":15},{"id":"GO:0007205","count":15},{"id":"GO:2001275","count":15}]},{"hash":"2143964560019120730","title":"Unknown","description":"The terms span liver apoptosis, ubiquitination, axonal transport, neural and glial development, and hair follicle morphogenesis, with no single dominant pathway or tissue context tying the proteins together. This lack of a coherent, shared function makes it inappropriate to assign a specific label beyond Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":5},{"id":"GO:0016567","count":4},{"id":"GO:0035871","count":3},{"id":"GO:0019896","count":3},{"id":"GO:0008090","count":3}]},{"hash":"524707251286761077","title":"Neuronal Synaptic Transmission and Plasticity","description":"The cluster is dominated by terms tied to neuronal signaling and plasticity: ion channels and transport (Na+/K+), excitatory postsynaptic potentials, GABA signaling, receptor internalization, and regulation of long-term synaptic plasticity, along with related behaviors and sensory system development, pointing to synaptic communication and learning mechanisms.","confidence":"High","size":18,"edges":27,"triangles":4,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":18},{"id":"GO:0071805","count":18},{"id":"GO:0007626","count":18},{"id":"GO:0060079","count":18},{"id":"GO:0007214","count":18}]},{"hash":"2253840407200210584","title":"Unknown","description":"The top GO terms cover a very broad and diverse set of functions\u2014from cell cycle and telomere maintenance to immune signaling, pain perception, and mechanotransduction\u2014without a single dominant theme tying the proteins together. Therefore, there isn\u2019t a concise, informative label that accurately represents the cluster as a coherent functional group.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0098907","count":8},{"id":"GO:0007049","count":7},{"id":"GO:0032212","count":6},{"id":"GO:0097497","count":6}]},{"hash":"270009216979416735","title":"Unknown","description":"The top GO terms are very diverse, spanning ubiquitin-dependent protein catabolic process and proteasome assembly (proteostasis), plant-specific processes (chlorophyll biosynthetic process, stamen formation), and broad developmental/immune signaling (brain development, NOD2 signaling, innate immune response, integrin signaling), plus mitotic spindle assembly. With no clear unifying function and no edges connecting proteins, there isn\u2019t a cohesive theme that ties all members together. Therefore this cluster is labeled Unknown.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006511","count":5},{"id":"GO:0015995","count":5},{"id":"GO:0043248","count":5},{"id":"GO:0048455","count":5},{"id":"GO:0007229","count":5}]},{"hash":"1625625933759233094","title":"Mitochondrial dynamics and muscle development","description":"The terms strongly point to mitochondrion-centered processes: distribution and inheritance of mitochondria, intracellular mitochondrial distribution, and regulation of cytochrome c release (apoptosis). Coupled with muscle-related terms (myoblast fusion and adult locomotory behavior) and the involvement of protein oligomerization, the cluster appears to capture proteins coordinating mitochondrial function with muscle development and apoptotic signaling, possibly affecting neuromuscular activity.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051260","count":9},{"id":"GO:0051262","count":6},{"id":"GO:0006915","count":5},{"id":"GO:1901741","count":5},{"id":"GO:0000001","count":5}]},{"hash":"1325180963459895233","title":"Immune signaling and cytoskeletal remodeling","description":"These proteins cluster around immune-related signaling events (B cell affinity maturation, IL-4 production, NK T cell differentiation) and cytoskeletal remodeling (small GTPase signaling, Rho and Ras regulation, lamellipodium assembly, and cell migration). While heart development and insulin signaling appear, the dominant theme is immune signal transduction coupled with cytoskeletal dynamics essential for immune cell activation and migration.","confidence":"High","size":18,"edges":32,"triangles":17,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":15},{"id":"GO:0008286","count":15},{"id":"GO:0007264","count":15},{"id":"GO:0016477","count":15},{"id":"GO:0002344","count":15}]},{"hash":"2238406848057725176","title":"Mitochondrial regulation of neuronal signaling and plasticity","description":"The cluster is enriched for mitochondrial-related processes (protein import into the mitochondrial matrix; mitochondrial membrane organization) together with neuronal signaling/plasticity terms (excitatory postsynaptic potential; regulation of long-term synaptic plasticity; adult locomotory behavior). Receptor internalization and apoptotic process hints reflect broader cellular trafficking and fate pathways linked to mitochondria in neurons. Taken together, the proteins seem to tie mitochondrial function to neuronal signaling and plasticity.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":5},{"id":"GO:0000002","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0031623","count":3},{"id":"GO:0048169","count":3}]},{"hash":"853880065832741983","title":"Developmental transcriptional regulation and morphogenesis","description":"This cluster centers on regulation of transcription by RNA polymerase II and several development-related processes across multiple tissues (midbrain, palate roof, enamel formation, pancreatic cells), along with extracellular matrix remodeling, suggesting a coherent role in developmental gene control and tissue morphogenesis.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":7},{"id":"GO:0045944","count":7},{"id":"GO:0060021","count":6},{"id":"GO:0003323","count":6}]},{"hash":"233917001858188400","title":"Unknown","description":"The terms span bacterial metabolic processes (antibiotic and PHB biosynthesis), lipid catabolism (triglyceride and sphingoid), and neural signaling and learning-related processes (PKC signaling, excitatory postsynaptic potential, habituation, and phosphorylation regulation), with no clear unifying function across the cluster. Given this mix and no interaction data to tie them together, there isn\u2019t a coherent single label to assign.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0042619","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0019433","count":5},{"id":"GO:0070528","count":4}]},{"hash":"783956504173032368","title":"mRNA Splicing Regulation and Processing","description":"The cluster\u2019s top GO terms center on spliceosome-mediated mRNA splicing with both positive and negative regulation, plus core processing steps like splice site recognition, export from the nucleus, and mRNA stabilization, indicating a shared role in mRNA maturation and fate. The presence of translation initiation/reinitiation terms suggests a link between splicing regulation and early translation control, pointing to a coherent module coordinating post-transcriptional gene expression.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":10},{"id":"GO:0031047","count":10},{"id":"GO:1901407","count":10},{"id":"GO:0045292","count":9},{"id":"GO:0001731","count":8}]},{"hash":"274583901503629521","title":"Ubiquitin-Dependent Degradation and TNF/JNK Signaling","description":"The top GO terms are dominated by ubiquitination-related processes (ubiquitin-dependent protein catabolic process, protein polyubiquitination, ERAD, autoubiquitination) and by regulation of TNF- and JNK-mediated signaling. This suggests proteins in this cluster function together in ubiquitin-mediated proteostasis and inflammatory signaling pathways, particularly TNF/JNK signaling, with some peripheral terms likely reflecting broader ubiquitin-related roles.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0030433","count":7},{"id":"GO:0000209","count":7},{"id":"GO:0046328","count":7},{"id":"GO:0033209","count":7}]},{"hash":"1050115813762762026","title":"Ribosome Biogenesis and Mitosis","description":"The strongest signals are ribosome biogenesis and mitotic cell cycle/cell division terms, suggesting a module focused on preparing protein synthesis for cell proliferation and division. Additional terms like ER-Golgi transport and GTPase regulation exist but are secondary, indicating broader cellular logistics rather than a single unified pathway. Overall, the cluster seems centered on growth-related machinery and mitosis, justifying the label.","confidence":"Medium","size":18,"edges":86,"triangles":197,"max_degree":16,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0000070","count":3},{"id":"GO:0001845","count":3}]},{"hash":"384311047964551990","title":"Dopamine/Adrenergic GPCR Signaling","description":"The cluster is dominated by GPCR-mediated signaling terms involving dopamine and adrenergic receptors, including adenylate cyclase-activating pathways and PLC activation, plus cAMP regulation. The presence of heart development and phototransduction terms suggests tissue contexts (heart/retina) where these GPCR pathways are active, supporting a focus on dopamine/adrenergic GPCR signaling.","confidence":"High","size":18,"edges":20,"triangles":9,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":17},{"id":"GO:0007507","count":16},{"id":"GO:0007603","count":16},{"id":"GO:0010513","count":16},{"id":"GO:0071880","count":16}]},{"hash":"1937336526004599252","title":"Unknown","description":"The top terms cover a broad mix of signaling (GPCR, NOD), immune regulation (IL-12), vascular/endothelial processes, telomere maintenance, mechanosensitive and muscle-related responses, and adipocyte differentiation, with no single unifying pathway or function clearly prevailing. This heterogeneity makes a cohesive, intuitive label difficult, so Unknown is appropriate.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007205","count":12},{"id":"GO:0098907","count":12},{"id":"GO:0032212","count":10},{"id":"GO:0097497","count":10},{"id":"GO:0070431","count":10}]},{"hash":"1407443496636451932","title":"mRNA processing and translational regulation","description":"This cluster centers on mRNA processing (splicing and polyadenylation) and the regulation of translation (initiation, reinitiation, IRES-driven translation, and mRNA stability), plus regulatory ncRNA\u2013mediated gene silencing, indicating a cohesive role in RNA maturation and translational control.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0045292","count":8},{"id":"GO:0002188","count":7},{"id":"GO:0075522","count":7},{"id":"GO:0075525","count":7}]},{"hash":"402989512428074661","title":"Epithelial Polarity and Tubulogenesis","description":"The GO terms are dominated by apical localization, establishment/maintenance of epithelial polarity, adherens junction components/assembly, and epithelial tube morphogenesis (lung and kidney collecting duct). This points to a cohesive theme of epithelial cell organization and tubulogenesis, with a few outliers in broader developmental contexts. ","confidence":"Medium","size":18,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":5},{"id":"GO:0045197","count":5},{"id":"GO:0072205","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0071896","count":4}]},{"hash":"376152091238936157","title":"Rho/Rac GTPase signaling and actin remodeling","description":"The top GO terms point to small GTPase-mediated signaling (Rho, Rac) with downstream effects on the cytoskeleton (lamellipodium assembly, cell spreading) and adhesion, plus associated signaling via insulin receptors and AMPA receptor clustering. This suggests a cohesive theme of signaling pathways that regulate actin dynamics and cell movement/adhesion, with neuronal and heart-development contexts reflecting broader roles in development and signaling. Confidence: High","confidence":"","size":18,"edges":15,"triangles":0,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":15},{"id":"GO:0008286","count":15},{"id":"GO:0032287","count":14},{"id":"GO:0097113","count":14},{"id":"GO:0035023","count":14}]},{"hash":"947605987475467434","title":"Bacterial polysaccharide and capsule biosynthesis","description":"The top GO terms point to multiple polysaccharide biosynthesis pathways (lipopolysaccharide, O antigen, colanic acid, sugar nucleotide donors like dTDP-rhamnose and ADP-L-glycero-beta-D-manno-heptose) and PHB biosynthesis, suggesting the cluster groups proteins involved in assembling bacterial surface polysaccharides and related carbon storage. Despite a couple of obsolete terms, the recurring theme is glycan/envelope biosynthesis and related metabolism.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":3},{"id":"GO:0009242","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0009103","count":3},{"id":"GO:0006541","count":3}]},{"hash":"1974520111415501302","title":"mRNA processing and post-transcriptional regulation","description":"This cluster centers on RNA maturation and regulation after transcription, tying together splice site recognition, mRNA export, stabilization, and poly(A) tail regulation, plus translation initiation and ncRNA-mediated gene silencing. While one term touches ribosome assembly, the dominant theme is control of gene expression at the RNA level, i.e., post-transcriptional processing and silencing pathways.","confidence":"High","size":18,"edges":58,"triangles":94,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":6},{"id":"GO:0006406","count":6},{"id":"GO:0048255","count":6},{"id":"GO:0035278","count":6},{"id":"GO:0031047","count":6}]},{"hash":"1776570239121241205","title":"Inflammation-driven Rac-dependent cytoskeletal remodeling","description":"This cluster is enriched for inflammatory signaling (interleukin-1 and TNF responses) and oxidative stress responses, combined with Rac-mediated actin dynamics (Rac signaling, ruffle assembly, and dendritic spine morphogenesis). The co-occurrence of cytokine responses with cytoskeletal remodeling terms suggests a theme of inflammation-related control of cell shape and motility, possibly linking signaling pathways like insulin receptor signaling to broader cytoskeletal regulation.","confidence":"Medium","size":18,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071347","count":5},{"id":"GO:0071356","count":5},{"id":"GO:0070301","count":5},{"id":"GO:0055091","count":4},{"id":"GO:0010628","count":4}]},{"hash":"857009964370802031","title":"Multi-tissue developmental lineage specification","description":"This cluster centers on diverse lineage-specific differentiation programs (myoblast/fetal muscle development, branchiomeric muscle, oligodendrocyte and inner ear sensory cell differentiation, osteoblast regulation, nephron morphogenesis) and regulatory processes (negative regulation of signaling and proliferation), plus immune-related development. The common thread is broad developmental fate specification across multiple tissues rather than a single pathway, justifying a multi-tissue developmental label.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045668","count":18},{"id":"GO:0060766","count":18},{"id":"GO:0007518","count":17},{"id":"GO:0006959","count":17},{"id":"GO:0042491","count":17}]},{"hash":"1505684263079211710","title":"Ubiquitin-Proteasome and ERAD Regulation","description":"The cluster centers on ubiquitination-related processes (protein ubiquitination, deubiquitination, autoubiquitination), sumoylation, and ER-associated degradation (ERAD), with proteasomal regulation as a common thread. Additional signals related to TNF signaling and erythrocyte differentiation appear as downstream or contextual associations, but the dominant theme is protein quality control and turnover via ubiquitin/ERAD pathways.","confidence":"High","size":18,"edges":144,"triangles":683,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0016579","count":5},{"id":"GO:0051865","count":5},{"id":"GO:1903265","count":5},{"id":"GO:0045648","count":5}]},{"hash":"2294957975911977997","title":"Rho-regulated Exocytosis and Exocyst-Mediated Trafficking","description":"Top GO terms cluster Rho protein signal transduction with vesicle trafficking steps central to exocytosis\u2014vesicle tethering, exocyst assembly/localization, Golgi-to-plasma membrane transport, and general protein transport\u2014together indicating a coherent role in Rho-dependent vesicle delivery and secretion at the plasma membrane.","confidence":"High","size":18,"edges":16,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":3},{"id":"GO:0032781","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0090522","count":2},{"id":"GO:2000535","count":2}]},{"hash":"1636155365740275085","title":"Mesodermal skeletal and cardiac morphogenesis","description":"This cluster is dominated by GO terms tied to mesoderm-based development and skeletal/heart formation: bone development, chondrocyte differentiation, embryonic cranial skeleton morphogenesis, left ventricular tissue morphogenesis, and mesoderm formation, plus axis specification. SMAD phosphorylation hints at TGF-beta signaling involved in these developmental processes, while DNA replication reflects proliferative phases during morphogenesis. Taken together, the terms point to embryonic development of mesoderm-derived skeletal and cardiac structures, justifying a label like \u201cMesodermal skeletal and cardiac morphogenesis.\u201d","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060348","count":4},{"id":"GO:0010614","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0007352","count":3},{"id":"GO:0048701","count":3}]},{"hash":"409505363138801114","title":"Golgi-ER Vesicle Trafficking","description":"The top GO terms cluster around Golgi localization, ER-to-Golgi vesicle transport, and vesicle budding, all pointing to intracellular trafficking and membrane dynamics centered on the Golgi. While there are some more general terms (e.g., mitotic cell cycle, dendrite development), the dominant signal is Golgi-associated vesicle transport and related GTPase regulation, justifying a trafficking-focused label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0000042","count":4},{"id":"GO:0000278","count":3},{"id":"GO:2000171","count":3},{"id":"GO:0033028","count":3}]},{"hash":"1351511754763246529","title":"Vertebrate Neurodevelopment and Organogenesis Signaling","description":"This cluster centers on developmental processes across the nervous system and multiple organs (kidney, heart, retina) with key signaling pathways (ROBO, SHH/Smo) guiding neural guidance and organogenesis, plus associated angiogenesis and neurite localization. The common theme is vertebrate developmental signaling driving neurodevelopment and organ formation.","confidence":"High","size":18,"edges":10,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007399","count":12},{"id":"GO:0001822","count":10},{"id":"GO:0035385","count":10},{"id":"GO:0022008","count":10},{"id":"GO:0007224","count":10}]},{"hash":"1687948917422825114","title":"Neurodevelopment and Organogenesis","description":"The top GO terms cluster around developmental processes across multiple organ systems\u2014nervous system development (including peripheral nervous system and axon guidance), heart and kidney morphogenesis, retina and sensory organ development, and angiogenesis\u2014along with related signaling and protein localization in neural regions. This points to a shared theme of developmental programs shaping neural and organogenesis functions.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0043330","count":11},{"id":"GO:0071206","count":11}]},{"hash":"1928850628529595901","title":"Developmental signaling and cell migration","description":"These proteins span multiple developmental processes (heart, parathyroid gland, osteoblast fate) and key signaling pathways (insulin receptor signaling, small GTPase signaling) as well as cytoskeletal and migratory processes (podosome assembly, cell migration) and signaling responses (nitric oxide, cholecystokinin). The common theme appears to be networks coordinating organogenesis with cell movement rather than a single tissue-specific function. ","confidence":"Medium","size":18,"edges":17,"triangles":0,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":14},{"id":"GO:0008286","count":14},{"id":"GO:0007264","count":14},{"id":"GO:0071800","count":14},{"id":"GO:0016477","count":14}]},{"hash":"1815159151483437192","title":"SNARE-regulated vesicle trafficking","description":"This cluster is driven by GO terms pointing to intracellular transport and membrane fusion, including Golgi-to-endosome transport, protein targeting to vacuoles, and synaptic vesicle maturation with SNARE complex regulation. The immune/platelet-related terms likely reflect secretory/granule processes tied to vesicle trafficking across cell types, supporting a unified vesicle transport function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006895","count":3},{"id":"GO:0001780","count":2},{"id":"GO:0030593","count":2},{"id":"GO:0030220","count":2},{"id":"GO:0006623","count":2}]},{"hash":"1653520116574742703","title":"Immune Activation and Cytokine Signaling Regulators","description":"The top GO terms point to immune-related activities (neutrophil chemotaxis; activated T cell proliferation; IL-2 production) and regulation of key signaling pathways (MAPK, STAT phosphorylation, insulin signaling). This suggests a cluster of proteins that modulate immune responses and intracellular signaling. Confidence is moderate because some terms are more general regulatory pathways rather than strictly immune-specific, but the immune activation theme is clear.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048661","count":3},{"id":"GO:0008285","count":2},{"id":"GO:0046627","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0030593","count":2}]},{"hash":"1085459092301014595","title":"Mitochondrial Translation and tRNA Aminoacylation","description":"The dominant terms are mitochondrial tRNA aminoacylation (aspartyl, asparaginyl, lysyl) and translation, indicating enrichment for mitochondrial protein synthesis. Telomere-related terms appear but are less represented, suggesting a secondary role elements rather than the primary function. High","confidence":"","size":18,"edges":40,"triangles":31,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0072581","count":8},{"id":"GO:0071915","count":8},{"id":"GO:0006412","count":8},{"id":"GO:0070146","count":8},{"id":"GO:0070145","count":8}]},{"hash":"98344247058548965","title":"Lateral line neuron signaling and development","description":"The cluster combines ion transport (K+/Na+), intracellular signaling, synaptic transmission and plasticity, receptor internalization, and developmental terms for the anterior/posterior lateral line, plus olfactory learning, indicating a set of proteins involved in neuronal signaling within the lateral-line sensory system and related sensory development.","confidence":"High","size":18,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0035725","count":5},{"id":"GO:0031623","count":4},{"id":"GO:0048169","count":4},{"id":"GO:0048915","count":4}]},{"hash":"785765571618601447","title":"Rho-GTPase signaling in neuronal development","description":"These GO terms cluster around signaling pathways in neurons: regulation of Rho protein signal transduction, phosphatidylinositol-mediated signaling, calcium response, and regulation of GTPase activity point to intracellular signaling; brain development and neurotransmitter secretion indicate neuronal function, while apoptotic regulation and glial cell apoptosis relate to neural tissue homeostasis. The combination supports a cohesive theme of Rho/GTPase\u2013mediated neuronal signaling during development.","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0043065","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0016525","count":4},{"id":"GO:0007269","count":4}]},{"hash":"8147409926516885","title":"Neural development and brain regionalization","description":"The top GO terms center on nervous system development and brain region specification (telencephalon, metencephalon, globus pallidus, spinal cord neuron differentiation), indicating a neural-focused cluster. While there are a few organogenesis terms (heart, pancreas), the predominant theme is neural development and regionalization.","confidence":"High","size":18,"edges":59,"triangles":41,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":16},{"id":"GO:0021759","count":15},{"id":"GO:0022037","count":13},{"id":"GO:1902870","count":13},{"id":"GO:0042663","count":13}]},{"hash":"1334198083516241093","title":"Budding yeast mitosis and bud-neck cytokinesis","description":"The cluster shows strong enrichment for mitosis-related terms (mitotic cytokinesis, exit from mitosis, mitotic cell cycle, cell division) and bud-neck localization, plus polarity maintenance, pointing to a cohesive module of cytokinesis and cell-cycle control in budding yeast.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007283","count":5},{"id":"GO:0000281","count":4},{"id":"GO:0006897","count":3},{"id":"GO:0010458","count":3},{"id":"GO:1901001","count":3}]},{"hash":"156522035678364890","title":"Nuclear RNA processing and genome maintenance","description":"The cluster shows enrichment for RNA processing and ribosome biogenesis (mRNA splicing, rRNA maturation) alongside proteostasis (ubiquitin-proteasome\u2013mediated protein degradation, protein polyubiquitination) and genome maintenance activities (DNA repair via SSA, DNA replication initiation) as well as mitotic spindle organization, suggesting a cohesive nuclear module focused on gene expression, RNA processing, and genome stability.","confidence":"Medium","size":18,"edges":133,"triangles":547,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0007052","count":2},{"id":"GO:0045071","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1172689431793648593","title":"Mitochondrial lipid biosynthesis and energy metabolism","description":"Top GO terms cluster around lipid biosynthesis and remodeling (cardiolipin, phosphatidylcholine, triglyceride, ether lipids) and mitochondrial energy production (mitochondrial ATP synthesis coupled electron transport). This suggests the proteins function together in mitochondrial lipid metabolism feeding oxidative phosphorylation, with a minor immune signaling note from one term. Confidence: High","confidence":"","size":18,"edges":81,"triangles":186,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":8},{"id":"GO:0010143","count":8},{"id":"GO:2001246","count":8},{"id":"GO:0035965","count":8},{"id":"GO:0036151","count":8}]},{"hash":"808030619153075093","title":"Adaptive immune response and endocytosis","description":"The cluster is dominated by adaptive immunity terms: complement activation (classical pathway), immunoglobulin production, and adaptive immune response, plus phagocytosis recognition, indicating immune activation and antigen handling. Several terms point to endocytic processes (endosome localization, recycling), suggesting shared trafficking machinery alongside immune functions. A placental morphogenesis term is less central but may reflect related epithelial signaling features; overall the theme is adaptive immunity with endocytic processing.","confidence":"High","size":18,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":4},{"id":"GO:0060672","count":3},{"id":"GO:0002377","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0006910","count":3}]},{"hash":"2277707109908446732","title":"Neuronal Ion Transport and Synaptic Vesicle Loading","description":"The GO terms point to membrane transport of multiple ions and metabolites, together with neuronal-specific processes like neurotransmitter loading into synaptic vesicles, and components of growth cone dynamics (actin nucleation and axon guidance), implying a cluster centered on neuronal transport and vesicle handling with cytoskeletal/guidance support.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0045010","count":4},{"id":"GO:0007411","count":4},{"id":"GO:0098700","count":4},{"id":"GO:0015707","count":4}]},{"hash":"1001301623474762852","title":"Neuronal synapse organization and signaling","description":"The cluster centers on neuronal synapses and associated signaling. GO terms include synapse organization, receptor localization to synapse, and dendrite development, plus Rho-mediated signal transduction and protein dephosphorylation, all of which support synaptic assembly and modulation. Additional terms like cellular response to morphine and paranodal junction maintenance point to mature neuronal connectivity, while sensory perception of light and sound reflect sensory neuron function integrated at synapses.","confidence":"High","size":18,"edges":139,"triangles":629,"max_degree":17,"top_function":"vesicle-mediated transport","top_go_terms":[{"id":"GO:0050821","count":10},{"id":"GO:0050808","count":8},{"id":"GO:0097120","count":8},{"id":"GO:0016358","count":8},{"id":"GO:0050953","count":8}]},{"hash":"1981396118903362013","title":"Signaling pathways and neural development regulators","description":"The cluster is enriched for receptor signaling terms (T cell receptor signaling and insulin receptor signaling) alongside neural development cues (cerebellar cortex formation, Bergmann glial cell differentiation, and axon regeneration). There are also cell-cycle related terms (negative regulation of CDK activity, negative regulation of cell population proliferation) and kinetochore localization, suggesting a broader theme of signaling that coordinates proliferation with neural development across contexts. Confidence in this cohesive theme is medium.","confidence":"Medium","size":18,"edges":114,"triangles":422,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":15},{"id":"GO:2001275","count":15},{"id":"GO:0008285","count":15},{"id":"GO:0048679","count":15},{"id":"GO:0008286","count":15}]},{"hash":"1346428887290700399","title":"mRNA processing and post-transcriptional regulation","description":"The top terms center on mRNA splicing (spliceosome), mRNA stability, export from nucleus, and regulatory silencing via miRNA, plus components of the translation initiation machinery. Together they point to coordinated post-transcriptional control of gene expression, involving splicing, mRNA fate, and translation regulation. ","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":14},{"id":"GO:0045292","count":11},{"id":"GO:0031047","count":11},{"id":"GO:1901407","count":11},{"id":"GO:0048026","count":11}]},{"hash":"451172814979395947","title":"Neuronal signaling, perception, and plasticity","description":"The top GO terms are dominated by neural processes\u2014sensory perception of pain, visual perception and learning, dopaminergic synaptic transmission, cocaine response\u2014and associated signaling pathways (ERK/MAPK cascade, protein phosphorylation), suggesting a cluster centered on neuronal signaling and plasticity, with a few outliers that may reflect broader signaling roles. ","confidence":"Medium","size":18,"edges":152,"triangles":800,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0001963","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0007601","count":12},{"id":"GO:0048148","count":12}]},{"hash":"1105330985218741557","title":"RNA processing linked to muscle and neural development","description":"This cluster is dominated by RNA processing terms (RNA splicing, mRNA processing, polyadenylation) suggesting a core theme of RNA metabolism. The other top GO terms point to developmental programs in muscle (skeletal and cardiac muscle development, regulation of muscle differentiation), neural development (dendrite morphogenesis, Purkinje cell migration), and broader differentiation contexts (erythrocyte differentiation, estrogen signaling). Together they imply a group of proteins coordinating RNA processing with diverse differentiation pathways, particularly in muscle and neural lineages.","confidence":"Medium","size":18,"edges":23,"triangles":20,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0008380","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0050885","count":6},{"id":"GO:0021942","count":6},{"id":"GO:2001014","count":6}]},{"hash":"870358458103829789","title":"DNA repair and xenobiotic response","description":"This cluster is dominated by GO terms for DNA repair and genome maintenance (DNA recombination, base-excision repair, alkylation repair, DNA damage response) along with cellular responses to xenobiotic stress ( xenobiotic stimulus, ethanol, cadmium). The combination suggests a cohesive module that links DNA damage repair with toxin/stress response pathways.","confidence":"High","size":18,"edges":39,"triangles":35,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":4},{"id":"GO:0042493","count":4},{"id":"GO:0006284","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0043966","count":3}]},{"hash":"420104119315035695","title":"Adhesion and Junction Signaling Across Tissues","description":"Top GO terms indicate a theme of intercellular contacts and junctions across diverse tissues (homophilic cell-cell adhesion, intermicrovillar adhesion, endothelial barrier formation, Purkinje\u2013myocyte adhesion, microvillus regulation) with supporting signals related to neuronal PSD-95 clustering and tissue-specific adhesion contexts. While some terms are more peripheral (melanosome transport, B cell differentiation), the core pattern supports a cluster anchored in adhesion and junctional communication. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":18},{"id":"GO:0032912","count":18},{"id":"GO:0086073","count":18},{"id":"GO:1903142","count":18},{"id":"GO:0007156","count":18}]},{"hash":"1184528834714416499","title":"Kidney and related embryonic morphogenesis","description":"The top GO terms clearly point to kidney/urinary tract development (metanephric distal/proximal tubule morphogenesis and mesonephric duct development), with cartilage condensation and lymph vessel morphogenesis suggesting broader embryonic organ morphogenesis. Some immune signaling and stress-related terms may be incidental annotations, but the dominant theme is organ morphogenesis with emphasis on nephron/urinary tract formation. ","confidence":"Medium","size":18,"edges":23,"triangles":10,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0072287","count":8},{"id":"GO:0001502","count":8},{"id":"GO:0036303","count":8},{"id":"GO:0072237","count":8},{"id":"GO:0072177","count":6}]},{"hash":"303057315606734162","title":"Polyamine metabolism and acetylation","description":"The strong enrichment for acetylation of polyamines (putrescine, spermidine, spermine) along with the L-arginine biosynthetic process points to a cohesive cluster centered on polyamine biosynthesis and their acetylation/turnover. While some terms like angiogenesis and melatonin biosynthesis surface, the dominant theme is polyamine metabolism and related acetylation modifications. ","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0032920","count":18},{"id":"GO:0018002","count":18},{"id":"GO:0006526","count":18},{"id":"GO:0032919","count":18},{"id":"GO:0060358","count":18}]},{"hash":"1686035324764167750","title":"Embryonic organogenesis","description":"The top GO terms point to development and morphogenesis across many organs (habenula, heart, retina/eye, hindlimb, gonads, prostate, osteoblasts), suggesting a broad program of organ formation rather than a single pathway. This cluster likely groups proteins involved in general organ development and tissue morphogenesis.","confidence":"High","size":18,"edges":121,"triangles":416,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021986","count":10},{"id":"GO:0002087","count":9},{"id":"GO:0007507","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0060527","count":9}]},{"hash":"661155134297998087","title":"Immune receptor signaling and activation","description":"The cluster is dominated by GO terms for B cell receptor signaling, T cell receptor signaling regulation, ERK cascade promotion, IL-2 production, adaptive immune response, and NK cell cytotoxicity, pointing to a cohesive theme of immune cell signaling and activation; additional terms on angiogenesis and cytoskeletal regulation (Rho, stress fibers) fit inflammatory contexts where immune cells interact with vasculature and remodel cytoskeleton.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0050853","count":11},{"id":"GO:0050860","count":11},{"id":"GO:0043552","count":10},{"id":"GO:0035023","count":10},{"id":"GO:0070374","count":9}]},{"hash":"2048033326497704937","title":"Developmental Proteostasis","description":"This cluster pairs protein homeostasis processes (SCF-dependent proteasomal degradation, ubiquitin pathways, ERAD, ribosome biogenesis) with development-related terms (multicellular organism development, skin development) and neural-related terms (sensory perception of sound, synaptic vesicle targeting), suggesting proteins involved in proteostasis during development across tissues. ","confidence":"Medium","size":18,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0016080","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1737138289335969535","title":"Developmental morphogenesis and signaling","description":"Multiple top GO terms point to developmental processes across organs: pancreatic beta-cell development, osteoblast differentiation, and branching morphogenesis in the ureteric bud. Additional terms reflect signaling mechanisms (Wnt, integrin) and epithelial-mesenchymal communication, all characteristic of organogenesis and tissue differentiation. The presence of negative regulation of cell growth and EMT-related signaling further supports a morphogenetic context rather than a single pathway.","confidence":"Medium","size":18,"edges":29,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0090263","count":3},{"id":"GO:0001649","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0050680","count":2}]},{"hash":"1584135337522689620","title":"Embryonic Development Across Organs","description":"The top GO terms point to development across multiple vertebrate organs (inner ear, midbrain, telencephalon, pituitary, digestive tract, ureteric bud, joints) and general multicellular development. A regulatory term (negative regulation of transcription by RNA Pol II) suggests transcriptional control during embryogenesis, indicating these proteins are likely involved in broad embryonic organogenesis rather than a single pathway.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0048839","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0048565","count":7},{"id":"GO:0021983","count":7}]},{"hash":"1468195821016574525","title":"Embryonic Organ Morphogenesis and Immune Signaling","description":"The cluster is enriched for developmental morphogenesis terms (mesonephric duct and metanephric tubule development, cartilage condensation, lymph vessel morphogenesis) and immune pathways (complement activation lectin pathway, Fc-gamma receptor signaling, response to fungal origin), implying proteins with roles in organ development that also engage immune signaling.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":18},{"id":"GO:0038094","count":18},{"id":"GO:0072287","count":18},{"id":"GO:2000502","count":18},{"id":"GO:0071226","count":18}]},{"hash":"1218847266726333939","title":"Neuronal Vision and Drug-Response Signaling","description":"The cluster is densely enriched for neural/visual and dopaminergic signaling terms: visual perception, opsin-mediated signaling, visual learning, dopaminergic synaptic transmission, and behavioral response to cocaine, all pointing to brain pathways involved in vision and reward. Positive regulation of ERK1/ERK2 cascade further supports MAPK-mediated neuronal signaling. Some other terms (heart development, macrophage chemotaxis, prostaglandin response) are broader but do not override the dominant neural/vision theme.","confidence":"High","size":18,"edges":129,"triangles":488,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":15},{"id":"GO:0070374","count":15},{"id":"GO:0001963","count":15},{"id":"GO:0048148","count":15},{"id":"GO:0071380","count":15}]},{"hash":"1655532208500411186","title":"Thermogenic Neural Autonomic Signaling","description":"Top GO terms cluster around temperature regulation and thermogenesis (diet-induced thermogenesis; cellular response to temperature stimulus) with concurrent neural and autonomic functions (dopaminergic synaptic transmission; brain renin-angiotensin system; blood pressure regulation; saliva secretion; GPCR signaling). This suggests a shared theme of neuroendocrine/autonomic control of body temperature and related physiological outputs, despite some metabolic terms like the electron transport chain being present. Therefore, the label reflects the dominant functional axis of the cluster.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0010579","count":9},{"id":"GO:0022900","count":9}]},{"hash":"207716201929966220","title":"Unknown","description":"The GO terms are highly diverse, including responses to chemicals (cocaine, dsRNA), developmental processes (angiogenesis, cardiac neural crest/heart development, organ regeneration), RNA processing (methylation and mRNA capping), signaling (MAPKK), and even biofilm formation. There isn\u2019t a single coherent function or pathway that ties these terms together across the proteins, so a unified, intuitive label isn\u2019t supported.","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042220","count":6},{"id":"GO:0031100","count":6},{"id":"GO:0036265","count":5},{"id":"GO:0006370","count":5},{"id":"GO:0033129","count":4}]},{"hash":"891205758151214726","title":"Brain adrenergic and dopaminergic signaling","description":"The top GO terms point to neuromodulatory signaling in the brain, including dopaminergic synaptic transmission and adrenergic receptor\u2013mediated pathways (MAPK and PLC activation) plus related vasoconstrictive/norepinephrine-epinephrine regulation of blood pressure. Although a few terms are peripheral, the dominant theme is brain adrenergic/dopaminergic signaling. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":17},{"id":"GO:0001963","count":17},{"id":"GO:1900453","count":17},{"id":"GO:0001994","count":17},{"id":"GO:0071883","count":17}]},{"hash":"2197656194494969539","title":"Brain Adrenergic-Dopaminergic Signaling","description":"The top GO terms cluster around brain neuromodulation: dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK- and PLC-activating), brain renin-angiotensin system, and regulation of synaptic plasticity. These point to a cohesive theme of brain-wide adrenergic/dopaminergic signaling and associated synaptic regulation, with a couple of outliers likely reflecting shared gene membership rather than core function. Confidence in this label is High.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"1908444868136347284","title":"Prenylated Protein Processing and Turnover","description":"Based on the Top Terms, the most specific and recurrent signals are CAAX-box protein processing and prenylated protein catabolic process, pointing to maturation and degradation of prenylated proteins. While other terms are more general housekeeping processes, these prenylation-related terms suggest the cluster centers on the processing and turnover of prenylated proteins, with some companion roles in proteostasis and organelle maintenance. ","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009820","count":2},{"id":"GO:0030327","count":2},{"id":"GO:0071586","count":2},{"id":"GO:0061077","count":2},{"id":"GO:0010637","count":2}]},{"hash":"986069154708233199","title":"Unknown","description":"The top GO terms span transcriptional regulation, development, immune response, digestion, extracellular matrix remodeling, and barrier formation, with no single cohesive theme tying them together, so there isn\u2019t a clear common function for the cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0030901","count":9},{"id":"GO:0032496","count":7},{"id":"GO:0045944","count":7},{"id":"GO:0007586","count":6}]},{"hash":"2026549892414910548","title":"Podosome assembly and cytoskeletal signaling","description":"Cluster centers on actin-rich adhesion structures (podosomes) and their regulation by Rho/integrin pathways, with associated cytoskeletal remodeling and morphogenesis signals. The prominent presence of podosome assembly, integrin signaling, and Rho-regulated cytoskeletal terms suggests a cohesive role in adhesion-mediated cytoskeletal dynamics and related morphogenetic processes.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0035023","count":10},{"id":"GO:0007229","count":8},{"id":"GO:0031532","count":8},{"id":"GO:0071803","count":8},{"id":"GO:0071560","count":7}]},{"hash":"612027039802480940","title":"Chromatin maintenance and genome stability","description":"This cluster gathers GO terms centered on chromatin state and genome integrity: histone deacetylation and subtelomeric heterochromatin formation, G-quadruplex DNA, and regulation of double-strand break repair via homologous recombination, plus protection from non-homologous end joining at telomeres. Ubiquitin-dependent protein catabolic processes (including via the multivesicular body pathway) suggest coordinated proteostasis linked to these chromatin- and DNA repair-related functions. While some terms (e.g., rRNA processing, centrosome localization, development) are less directly connected, the dominant theme is maintenance of chromatin structure and genome stability, with supporting roles for protein turnover. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016575","count":3},{"id":"GO:0035390","count":2},{"id":"GO:0071919","count":2},{"id":"GO:0010569","count":2},{"id":"GO:0031848","count":2}]},{"hash":"1280153168790532184","title":"Telomere maintenance and telomerase regulation","description":"This cluster is dominated by GO terms related to telomere assembly, telomere maintenance via telomerase, telomere capping, and protein localization to telomeres, along with components involved in telomeric DNA elongation and D-loop dynamics. The common theme is telomere biology and telomerase-driven maintenance of chromosome ends, with associated RNP localization. Confidence reflects a coherent, high-level telomere-centric theme across the terms.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032202","count":4},{"id":"GO:0032212","count":2},{"id":"GO:0016233","count":2},{"id":"GO:0051973","count":2},{"id":"GO:1905776","count":2}]},{"hash":"1895178687285318953","title":"Neurotransmission and autonomic vascular regulation","description":"The cluster is enriched for neural signaling terms, including dopaminergic synaptic transmission, brain renin-angiotensin system, and norepinephrine-epinephrine\u2013mediated vasoconstriction, which point to neural and autonomic control of vascular function. Additional terms related to temperature regulation and diet-induced thermogenesis support metabolic-neural connections, while immune/platelet terms are less central. Thus, the core theme is neural signaling coupled with autonomic vascular regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009253","count":6},{"id":"GO:0006955","count":6},{"id":"GO:0030168","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6}]},{"hash":"571878537775632704","title":"Cell cycle control and proteasomal degradation","description":"The cluster\u2019s top terms center on mitotic cell cycle and cell division, plus SCF-dependent ubiquitin-proteasomal degradation, which together suggest coordination of progression through division with targeted protein turnover. Additional terms indicate signaling and cytoskeletal regulation (GTPase activity, tyrosine phosphorylation, and actin filament capping) and a developmental context (male gonad development), pointing to a broader network that ties cell-cycle control to signaling and cytoskeletal dynamics during development.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0071560","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3}]},{"hash":"943680124360138945","title":"Unknown","description":"Top GO terms cover diverse processes (immune receptor signaling, muscle and organ morphogenesis, insect eye development, epithelial polarity, infection structure formation, and synaptic vesicle trafficking), with no common theme linking all proteins. With no edges and a broad mix of functions, there is no cohesive function to label the cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0050853","count":4},{"id":"GO:0048741","count":4},{"id":"GO:0001744","count":3},{"id":"GO:0042248","count":3},{"id":"GO:0075015","count":3}]},{"hash":"1578065361602868861","title":"GPCR-Mediated Immune Signaling","description":"The top GO terms cluster around GPCR signaling (adenylate cyclase-activating GPCR pathway), positive regulation of Rho GTPase activity, ERK/MAPK cascade activation, and neutrophil chemotaxis, along with defense responses to bacteria. These together point to GPCR-driven signal transduction that promotes immune cell recruitment and inflammatory signaling; a coherent theme despite some metabolic or sensory terms present. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":13},{"id":"GO:0035025","count":13},{"id":"GO:0010579","count":13},{"id":"GO:0045777","count":13},{"id":"GO:0007601","count":11}]},{"hash":"1225911094803712087","title":"Neural adrenergic and dopaminergic signaling","description":"This cluster is dominated by GO terms tied to brain-specific signaling and neurotransmission, including the brain renin-angiotensin system, dopaminergic synaptic transmission, and adrenergic receptor\u2013mediated pathways (MAPK- and PLC-activated). These consistently point to neural communication and regulation of vascular tone, suggesting a cohesive theme around neural adrenergic and dopaminergic signaling, with a few outlier immune-related terms that do not redefine the main function.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"1891488024087275746","title":"Embryogenesis and morphogenesis","description":"The terms cluster around early development and tissue formation: left/right patterning, endocardial cushion EMT, endocrine/pancreatic development, trophoblast and cartilage morphogenesis, and extracellular matrix remodeling. Together they point to broad embryonic patterning and morphogenesis across multiple tissues, with regulatory transcription control sometimes involved.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0003198","count":7},{"id":"GO:0035270","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0060806","count":7}]},{"hash":"2074155725296506077","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The terms reveal a core theme of ubiquitination pathways (ubiquitin-dependent proteolysis, autoubiquitination, K6 and K63 linkages) coupled with innate immune defense against viruses and TNF signaling. Additional hints include histone catabolic/chromatin turnover and circadian rhythm regulation, suggesting a broader link between protein turnover and immune/circadian processes.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0051865","count":6},{"id":"GO:1903265","count":6}]},{"hash":"488795472215359715","title":"Ubiquitin-Driven Proteolysis and TNF Signaling","description":"Most top GO terms point to ubiquitin-dependent protein catabolic processes and polyubiquitination, including SCF-dependent proteasomal degradation and autoubiquitination, indicating a cluster enriched for ubiquitin-proteasome system components. Several terms also highlight TNF-mediated signaling and innate immune responses, suggesting a link between protein turnover and inflammatory signaling. A few terms (e.g., synapse assembly) appear tangential, and one outlier (dosage compensation) is not central to the core theme. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0000209","count":8},{"id":"GO:0060386","count":6},{"id":"GO:0031146","count":6},{"id":"GO:0033209","count":5}]},{"hash":"302878588233894900","title":"Brain adrenergic and dopaminergic signaling","description":"This cluster is dominated by GO terms related to brain neurochemical signaling, especially adrenergic receptor pathways (MAPK-activating and phospholipase C-activating) and dopaminergic synaptic transmission, with related regulation of synaptic plasticity and vascular effects; a few immune-related terms appear but do not define the main theme. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":18},{"id":"GO:0001963","count":18},{"id":"GO:1900453","count":18},{"id":"GO:0001994","count":18},{"id":"GO:0071883","count":18}]},{"hash":"2195037689229042930","title":"Neuroimmune signaling and axon guidance","description":"The cluster combines neural development and axon-associated terms (nervous system development, paranode localization, roundabout/ROBO signaling, Smoothened/Hedgehog) with multiple immune signaling pathways (T cell receptor signaling, Th2 cytokine production, IL-27 signaling, type II interferon production) and common signal transduction routes (PI3K-AKT). This pattern suggests a cohesive theme of signaling cross-talk between nervous system development/maintenance and immune responses, i.e., neuroimmune signaling with axon guidance components.","confidence":"Medium","size":17,"edges":128,"triangles":572,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042517","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0050852","count":8},{"id":"GO:0035745","count":7},{"id":"GO:0035385","count":7}]},{"hash":"1332862551108576669","title":"Mitochondrial metabolite transport and membrane dynamics","description":"The top GO terms point to transmembrane transport of various mitochondrial cofactors and metabolites (NAD, thiamine pyrophosphate, glycine, deoxynucleotides, ornithine) and to mitochondrial membrane processes (fission and permeability regulation). This pattern suggests the proteins function together in mitochondrial transport and membrane remodeling.","confidence":"High","size":17,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035352","count":7},{"id":"GO:0034198","count":7},{"id":"GO:0000066","count":7},{"id":"GO:0097421","count":7},{"id":"GO:0036233","count":7}]},{"hash":"442480014161862255","title":"Early embryonic morphogenesis and heart development","description":"This cluster centers on embryonic tissue patterning and organ formation, especially gastrulation (primitive streak), heart field specification and outflow tract morphogenesis, and craniofacial/roof-of-mouth development, with supporting signals in osteoblast differentiation and transcription. A plant-specific term likely represents annotation cross-talk, but the dominant theme is vertebrate embryogenesis and cardiac morphogenesis, so the label is representative.","confidence":"Medium","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090009","count":12},{"id":"GO:0010076","count":11},{"id":"GO:0048703","count":11},{"id":"GO:0060021","count":11},{"id":"GO:0071277","count":10}]},{"hash":"611801319072476241","title":"Plant cell wall biosynthesis and sugar metabolism","description":"The cluster is dominated by GO terms tied to plant carbohydrate metabolism and cell wall formation, including GDP-mannose biosynthesis (a key donor for polysaccharides), cell wall organization, and glucose-1-phosphate/galactose catabolic processes. The gravity detection and post-embryonic development terms align with plant growth and tissue expansion processes that depend on cell wall remodeling. Together, these terms suggest a cohesive theme of plant-specific carbohydrate metabolism fueling cell wall biosynthesis and growth.","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":7},{"id":"GO:0009791","count":5},{"id":"GO:0071555","count":5},{"id":"GO:0042594","count":4},{"id":"GO:0019388","count":4}]},{"hash":"2156235004492988617","title":"Angiogenesis and immune-endothelial interactions","description":"This cluster centers on vascular development and remodeling, with strong signals for angiogenesis, endothelial cell migration, and extracellular matrix interactions (cell-matrix adhesion, hyaluronan metabolism), along with regulators of ERK signaling and Rho pathways, plus adaptive immune response components, pointing to coordinated angiogenesis with immune and matrix regulation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007160","count":9},{"id":"GO:0001525","count":9},{"id":"GO:0002250","count":9},{"id":"GO:0070374","count":9},{"id":"GO:0045907","count":8}]},{"hash":"298020637357341201","title":"Ribosome Biogenesis and Cell Division","description":"This cluster is dominated by terms for ribosome assembly and export (ribosome biogenesis, ribosomal subunit export, tRNA modification) alongside cell cycle/division processes (cell cycle, cell division, cell septum assembly). The co-occurrence of these core growth-related processes suggests a cohesive theme tying protein synthesis capacity to cytokinesis. Some stress-response regulation terms appear, likely reflecting growth-state modulation of translation, but the central pattern connects ribosome biogenesis with cell division.","confidence":"High","size":17,"edges":36,"triangles":5,"max_degree":10,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0007049","count":12},{"id":"GO:0000055","count":12},{"id":"GO:0051301","count":12},{"id":"GO:1901001","count":11},{"id":"GO:0042274","count":11}]},{"hash":"2112318412903326112","title":"ER Stress Response and Protein Folding","description":"These terms cluster around the endoplasmic reticulum quality-control network: unfolded protein response, ER-associated translation regulation, ER protein folding, and redox/homeostasis processes, including chaperone-assisted refolding and deglutathionylation. This makes the label both concise and representative of the cluster\u2019s function.","confidence":"High","size":17,"edges":43,"triangles":34,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":10},{"id":"GO:0034975","count":8},{"id":"GO:0070389","count":7},{"id":"GO:0055114","count":6},{"id":"GO:0098869","count":6}]},{"hash":"1275525143714571664","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0072715","count":15},{"id":"GO:0018144","count":15},{"id":"GO:0000716","count":15},{"id":"GO:0034476","count":15}]},{"hash":"1438676355948324193","title":"Axonal transport and cytoskeleton organization","description":"The set of terms centers on neural and glial development processes linked to intracellular transport and microtubule dynamics: axonal transport of mitochondria and retrograde axonal transport point to cargo movement along axons, while establishment or maintenance of microtubule cytoskeleton polarity highlights cytoskeletal organization essential for neural extension and cell signaling. Additional terms like astrocyte and Schwann cell development and related morphogenesis support a broader neurodevelopmental context, but the strongest recurring theme remains transport coupled to cytoskeletal organization.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:0019896","count":2},{"id":"GO:0008090","count":2},{"id":"GO:0097284","count":2},{"id":"GO:0014002","count":2}]},{"hash":"1216441978945039369","title":"Neural Sensory Perception and Dopaminergic Signaling","description":"This cluster is dominated by GO terms related to sensory perception (pain and vision), visual learning, and neural signaling, including dopaminergic synaptic transmission, morphine response, and ERK cascade regulation. The presence of brain-specific terms (brain renin-angiotensin system) alongside temperature- and diet-related sensory responses suggests a brain-centric network integrating sensory processing with neuromodulatory signaling pathways.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0008542","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0002024","count":6},{"id":"GO:0007601","count":5}]},{"hash":"1944763257448994857","title":"Developmental transcription and chromatin regulation","description":"These terms point to a group involved in regulating gene expression and chromatin structure during development, including DNA-templated transcription, chromatin organization, and cell-cycle control. Additional terms like TGF-beta response and fertilization reflect developmental signaling contexts, while ERAD and oligomerization contribute to general protein quality control and assembly. Overall, the cluster seems to center on transcriptional regulation and chromatin dynamics in development and cell-cycle processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0007275","count":8},{"id":"GO:0007338","count":8},{"id":"GO:0030433","count":7},{"id":"GO:1901976","count":7}]},{"hash":"1523863428274354381","title":"Bacterial fatty acid biosynthesis and envelope components","description":"The cluster is centered on lipid metabolism and cell envelope biosynthesis in bacteria: fatty acid biosynthesis and long-chain fatty acid metabolism, plus biosynthetic processes for lipopolysaccharide and lipoteichoic acid, and fatty acid transport. These together point to a cohesive module for membrane lipid production and envelope assembly, though one bioluminescence term is an outlier. ","confidence":"High","size":17,"edges":31,"triangles":11,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":8},{"id":"GO:0009103","count":6},{"id":"GO:0090410","count":5},{"id":"GO:0006633","count":5},{"id":"GO:0001676","count":5}]},{"hash":"701030377612129704","title":"Calcium signaling and calcineurin\u2013NFAT regulation","description":"The cluster\u2019s top GO terms cluster around calcium signaling: release of sequestered calcium into the cytosol, calcium transmembrane transport, and calcium-modulated Wnt signaling, along with regulation of the calcineurin\u2013NFAT pathway. This suggests a cohesive calcium-dependent signaling module involved in stress responses and transcriptional regulation, with a few unrelated terms likely representing incidental associations.","confidence":"High","size":17,"edges":16,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0051281","count":3},{"id":"GO:0007223","count":3},{"id":"GO:0000272","count":2},{"id":"GO:0014898","count":2},{"id":"GO:0051531","count":2}]},{"hash":"992559342529792019","title":"Cell Cycle and Transcription Regulation","description":"Top terms indicate strong signals for mitotic cell cycle, cell division, and G2/M transition, together with DNA-templated transcription and RNA polymerase II preinitiation complex assembly, pointing to a module centered on coordinating proliferation with gene expression. While a few terms relate to development in specific tissues and a couple to cytoskeletal assembly (microspike) or myelination, the dominant theme remains nuclear regulation of cell cycle and transcription.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0045498","count":2},{"id":"GO:0072205","count":2},{"id":"GO:0051301","count":2}]},{"hash":"549221239412262674","title":"Integrin signaling and immune receptor regulation","description":"These proteins are enriched for integrin signaling, NK cell cytotoxic pathways, and regulation of lymphocyte receptor signaling, together with Rho/cytoskeleton dynamics, indicating a cluster of integrin- and immune-receptor\u2013driven signaling with cytoskeletal regulation.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007229","count":14},{"id":"GO:0042267","count":14},{"id":"GO:0060337","count":14},{"id":"GO:0038063","count":13},{"id":"GO:0051492","count":13}]},{"hash":"1966801213891524371","title":"Histone Modification and Chromatin Regulation","description":"The top GO terms are dominated by histone modifications and chromatin-related regulation (H3-K27 trimethylation, H3-K4 demethylation, H3-K23 acetylation, and regulation of heterochromatin via DNA methylation), indicating a cluster centered on epigenetic control of chromatin state. There are some unrelated terms like spindle assembly and spermatid differentiation, but the shared theme across most terms points to chromatin remodeling and histone modification. Confidence reflects that epigenetic regulation is the primary signal, with minor noise from ancillary terms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":4},{"id":"GO:0045869","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0090308","count":3},{"id":"GO:0034720","count":3}]},{"hash":"677169830234092703","title":"Multi-lineage cell fate specification","description":"These GO terms cluster around differentiation and cell fate decisions across multiple tissues (neuronal subtypes, oligodendrocytes, skeletal muscle, melanocytes, pancreas, bronchioles), suggesting a shared theme of lineage specification rather than a single tissue-specific function.","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0031018","count":12},{"id":"GO:0060163","count":11},{"id":"GO:0021530","count":11},{"id":"GO:0060435","count":11}]},{"hash":"1293537077633898649","title":"Chondrogenesis and Osteogenesis","description":"The cluster is dominated by terms related to cartilage and bone development, including chondrocyte differentiation, BMP signaling regulation, and osteoblast differentiation, suggesting a focus on skeletal formation and craniofacial morphogenesis (e.g., roof of mouth development and related morphogenesis). Some terms are broader developmental or immune signals, but the core pattern points to cartilage formation and bone growth.","confidence":"High","size":17,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":5},{"id":"GO:0032331","count":4},{"id":"GO:0010763","count":4},{"id":"GO:0030513","count":4},{"id":"GO:0045669","count":4}]},{"hash":"1025474539863634110","title":"Synaptic vesicle exocytosis and Golgi-ER trafficking","description":"The top GO terms cluster around neurotransmitter release and vesicle trafficking: SNARE complex assembly, exocytic insertion of receptors, calcium-regulated exocytosis, and synaptic vesicle fusion to the presynaptic membrane. Additional terms describe ER-Golgi transport and Golgi ribbon formation, plus retrograde transport and long-term potentiation, all tied to vesicle cycling and synaptic maintenance. This makes a cohesive label for a vesicle trafficking/exocytosis focused cluster relevant to synaptic function.","confidence":"High","size":17,"edges":29,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035493","count":8},{"id":"GO:0098967","count":8},{"id":"GO:0006888","count":5},{"id":"GO:0031629","count":5},{"id":"GO:0048791","count":5}]},{"hash":"1471661038757262396","title":"T Cell Signaling and Cytoskeletal Remodeling","description":"This cluster centers on immune signaling via the T cell receptor pathway and extensive actin cytoskeleton dynamics (actin polymerization and branching, GTPase regulation), all converging on cell shape, polarity, and synapse-like interfaces. The inclusion of tight junction assembly and apoptotic cell engulfment suggests broader roles in cell-cell contact and phagocytic engagement, while Wnt pathway regulation hints at upstream signaling crosstalk that can tune these remodeling processes. Overall, the proteins appear to coordinate immune signaling with cytoskeletal rearrangements and interface formation.","confidence":"Medium","size":17,"edges":9,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0050852","count":6},{"id":"GO:0051835","count":6},{"id":"GO:0030838","count":6}]},{"hash":"905722727080193718","title":"Embryonic and Neural Development with Stress Signaling","description":"The cluster is dominated by developmental GO terms (neural tube closure, forebrain and skeletal development, multicellular organism development) and cell cycle activity, with additional stress/defense signals (ER stress\u2013related apoptosis, cadmium response, Gram-positive defense). This suggests proteins involved in developmental programs that also engage cellular stress pathways, indicating a coherent theme of development linked to stress signaling.","confidence":"Medium","size":17,"edges":35,"triangles":33,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":17},{"id":"GO:0050830","count":17},{"id":"GO:0001843","count":17},{"id":"GO:0007275","count":17},{"id":"GO:0071276","count":17}]},{"hash":"1217117129405964960","title":"Skeletal muscle autophagy and mitophagy","description":"Based on the top GO terms, autophagy-related processes dominate (autophagosome assembly, autophagy of mitochondrion, glycophagy, and regulation of autophagy in response to ER overload), with concurrent signals for skeletal muscle fiber development, suggesting a cluster of proteins involved in muscle-specific autophagy and turnover of mitochondria and glycogen rather than a single, isolated pathway.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0006612","count":2},{"id":"GO:0043653","count":2},{"id":"GO:0034263","count":2}]},{"hash":"1099187759241896242","title":"Neuronal cytoskeleton dynamics and myelination","description":"GO terms point to endocytosis, actin-based filopodium assembly, and Rac signaling, all tied to cytoskeletal remodeling in neural cells. The inclusion of peripheral myelination (PNS) and Rac pathway regulation suggests a unifying role in nervous system development and Schwann cell\u2013mediated myelination.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0016601","count":2},{"id":"GO:1904424","count":2}]},{"hash":"1922461628571986772","title":"Cytoskeleton dynamics and cell adhesion","description":"The top GO terms cluster around cytoskeletal organization and cell\u2013cell interfaces: cell adhesion, establishment/maintenance of cell polarity affecting cell shape, mitotic spindle assembly, regulation of microtubule depolymerization, actin cytoskeleton reorganization, and dynein-driven movement. Together these point to a cohesive function in cytoskeleton dynamics and adhesion/motility. Some terms (e.g., cuticle development, IL-2 production, intestinal glucose absorption) appear peripheral and do not alter the main theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":4},{"id":"GO:0071963","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0007026","count":3},{"id":"GO:0031532","count":3}]},{"hash":"1697213605019389805","title":"Cardiovascular development and vascular function","description":"The cluster is enriched for heart development and blood vessel maintenance, with nitric oxide biosynthesis regulation pointing to vascular tone control. Additional signals related to erythrocyte differentiation and oxidative stress handling further tie to blood and endothelial contexts, while receptor-mediated endocytosis and protein interactions are common in vascular cells. Overall, the dominant theme is cardiovascular development and vascular regulation, with some blood-related processes included.","confidence":"High","size":17,"edges":60,"triangles":90,"max_degree":14,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0045429","count":5},{"id":"GO:0043353","count":5},{"id":"GO:0042744","count":5},{"id":"GO:0010764","count":5},{"id":"GO:0006898","count":5}]},{"hash":"2003597883698569991","title":"Rho/Rac GTPase signaling and cell migration","description":"The cluster is dominated by GO terms related to Rho-family GTPase signaling (Rho, Rac), small GTPase-mediated pathways, and actin cytoskeleton dynamics (cell migration, podosome assembly, membrane tubulation) with associated polarization processes (epithelial polarity) and developmental context (heart development). This points to a cohesive module centered on GTPase-driven cytoskeletal remodeling and motility.","confidence":"High","size":17,"edges":27,"triangles":0,"max_degree":13,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":9},{"id":"GO:0006355","count":6},{"id":"GO:0007264","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0071803","count":6}]},{"hash":"1924621562289598908","title":"Neural circuit formation and heart/muscle development","description":"The GO terms point to neural connectivity processes (axonal fasciculation, myelination, positive regulation of synapse assembly) alongside cardiac/muscle morphogenesis (heart development, sarcomere organization) and cell adhesion, with Rho signaling-related regulation as a cytoskeletal facilitator. While some terms like otolith morphogenesis and innate immune response are less central, the dominant theme ties neural wiring to cardiac/muscular tissue development, justifying this label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0032474","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0007413","count":4}]},{"hash":"2170659807858014491","title":"Embryonic transcriptional regulation and morphogenesis","description":"The GO terms cluster around transcriptional control and chromatin remodeling, with multiple embryonic development processes (pancreas and gonad development, neural crest migration, ureteric bud branching, digestive tract morphogenesis, and overall multicellular development). This suggests a group of proteins involved in regulating gene expression during embryogenesis and tissue morphogenesis.","confidence":"Medium","size":17,"edges":17,"triangles":4,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0006351","count":9},{"id":"GO:0031018","count":8},{"id":"GO:0008584","count":7},{"id":"GO:0071560","count":7}]},{"hash":"480288317702246505","title":"Actin Cytoskeleton Remodeling and Mitotic Machinery","description":"Most frequent GO terms cluster around actin cytoskeleton dynamics (microspike assembly, actin filament bundle assembly, vesicle transport along actin filament, regulation of Rho signaling). Additional terms reflect mitotic processes (centrosome cycle, spindle assembly), suggesting a link between cytoskeletal remodeling and cell division. A few signaling terms (PI3K/AKT modulation, IL-2 production) may reflect broader signaling contexts accompanying actin remodeling in immune or proliferating cells. Overall, the cluster seems dominated by actin-related remodeling and mitotic machinery, justifying the label.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030035","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007098","count":2},{"id":"GO:0051225","count":2},{"id":"GO:1900042","count":2}]},{"hash":"183300562936492204","title":"Gene Expression and Translation Regulation","description":"The top terms cluster around core gene expression processes: transcription (DNA-templated transcription, transcription termination) and chromatin organization, along with translation-related terms (translation, cytoplasmic translational termination). The presence of related stress response terms (response to antibiotic/cycloheximide) and energy metabolism (mitochondrial ATP synthesis) suggests a broader theme of coordinating gene expression with cellular energy and stress, justifying a label focused on gene expression and translation regulation.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0046677","count":2},{"id":"GO:0046898","count":2},{"id":"GO:0002184","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2234067191389556049","title":"Cell signaling in migration, development, and immunity","description":"The GO terms cluster around signaling pathways (e.g., insulin signaling, small GTPase and Rho regulation) that control cell movement, development, immune responses, and related processes, suggesting a unifying theme of signaling guiding diverse cell behaviors.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007340","count":3},{"id":"GO:0090051","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1344190889981627136","title":"Organogenesis and Tissue Differentiation","description":"These proteins show enrichment for keratinization and multiple developmental processes across tissues (brain regionalization, spinal cord, heart, pancreas, and endocrine differentiation). The common thread is broad developmental differentiation and organogenesis rather than a single, specific function, so a cross-tissue development label fits best.","confidence":"Medium","size":17,"edges":48,"triangles":121,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":10},{"id":"GO:0007275","count":4},{"id":"GO:0022037","count":3},{"id":"GO:1902870","count":3},{"id":"GO:0042663","count":3}]},{"hash":"2151963269885613581","title":"ERK-regulated development and morphogenesis","description":"This cluster centers on ERK1/2 cascade activation and its regulation, with accompanying developmental and morphogenetic processes such as midbrain-hindbrain boundary development, endothelial tube morphogenesis, digestive tract development, and integrin activation. The recurring ERK-related terms and associated developmental functions suggest a cohesive theme of ERK-mediated developmental signaling and tissue morphogenesis.","confidence":"Medium","size":17,"edges":37,"triangles":26,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0034605","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0070371","count":2},{"id":"GO:0048566","count":2},{"id":"GO:1901509","count":2}]},{"hash":"435446118079178654","title":"Mitochondrial respiration and protein import","description":"Dominant terms describe mitochondrial inner-membrane processes and energy metabolism\u2014proton transport, protein import into the matrix, inner-membrane insertion, and respirasome assembly\u2014consistent with aerobic respiration. Occasional terms for chloroplast import and CNS development are peripheral to the core mitochondrial theme, but do not negate the primary signal. Overall, the cluster likely represents mitochondrial respiration and protein import machinery.","confidence":"High","size":17,"edges":124,"triangles":516,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":5},{"id":"GO:0007417","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0045039","count":2}]},{"hash":"277120109089604379","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":69,"triangles":131,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":16},{"id":"GO:0007601","count":16},{"id":"GO:0043547","count":14},{"id":"GO:0010224","count":13},{"id":"GO:1905869","count":13}]},{"hash":"1729641715113770468","title":"RNA granules and translational regulation","description":"The cluster is dominated by GO terms tied to mRNA metabolism and local translational control, including P-body and stress granule assembly, translational initiation regulation, miRNA-mediated silencing control, and decapping/decay pathways, as well as circadian and synaptic regulation that are influenced by translation. This suggests a functional cluster centered on RNA granules coordinating translation and mRNA turnover, with some signaling links.","confidence":"High","size":17,"edges":120,"triangles":500,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045947","count":11},{"id":"GO:0033962","count":10},{"id":"GO:0090328","count":9},{"id":"GO:0060965","count":9},{"id":"GO:0034063","count":9}]},{"hash":"1168825732655537333","title":"Macrophage activation and lipid remodeling","description":"This cluster converges on immune activation in macrophages (regulation of macrophage activation; IL-1 and IL-8 production) and concurrent lipid handling (lipid storage regulation, lipid catabolic processes, and phospholipid acyl-chain remodeling), including foam-cell differentiation. This points to a coordinated inflammatory response in macrophages paired with lipid metabolism, a pattern relevant to atherosclerosis-related processes.","confidence":"Medium","size":17,"edges":17,"triangles":1,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0043030","count":2},{"id":"GO:0032612","count":2},{"id":"GO:0010744","count":2},{"id":"GO:0036148","count":2},{"id":"GO:0036152","count":2}]},{"hash":"1168045388797943894","title":"Mitotic regulation and signaling","description":"Proteins in this cluster touch on several signaling pathways (Notch, T cell receptor, MAPK/JNK) and mitotic controls (spindle elongation, chromatid biorientation, chromosome passenger complex localization). The combination suggests a set of regulators coordinating cell cycle progression with signaling cascades; one term about postsynaptic density assembly is less aligned, but overall pattern is signaling and mitosis regulation.","confidence":"Medium","size":17,"edges":22,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":4},{"id":"GO:0050860","count":4},{"id":"GO:0035853","count":3},{"id":"GO:0097107","count":3},{"id":"GO:0035970","count":3}]},{"hash":"905328084438933088","title":"Developmental and immune signaling regulators","description":"This cluster shows enrichment for regulatory processes across development (cornea and heart development, stem cell maintenance), immune signaling (IL-1\u03b2 and interferon-\u03b1 production), and pathways responding to TGF-\u03b2, with supporting epigenetic and post-translational regulation (acetylation, sumoylation, DNA methylation). Taken together, it suggests proteins that modulate signaling and gene regulation in development and immunity, hence the label Developmental and Immune Signaling Regulators.","confidence":"Medium","size":17,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050718","count":3},{"id":"GO:0061303","count":3},{"id":"GO:2000761","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0033234","count":2}]},{"hash":"652314070660100653","title":"Neural development and synaptic adhesion","description":"The top GO terms are dominated by cellular adhesion (homophilic and heterophilic) and neural-related processes, including positive regulation of synapse assembly and nervous system development, suggesting these proteins function together in neural connectivity and tissue interactions. While there are a few terms related to bone maturation and pigment cell processes, the strongest, most coherent theme is neural development and synaptic adhesion.","confidence":"High","size":17,"edges":72,"triangles":136,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":13},{"id":"GO:0051965","count":13},{"id":"GO:0007399","count":13},{"id":"GO:0007157","count":13},{"id":"GO:0043931","count":13}]},{"hash":"1967090708799946081","title":"Inflammation and Coagulation with Angiogenesis","description":"This cluster shows strong signals for acute-phase response, fibrinolysis, blood coagulation, cytokine production, and angiogenesis, with additional links to Wnt signaling. Together these terms point to a set of proteins involved in inflammatory responses that couple to vascular remodeling and coagulation processes, rather than a single narrow function. While some terms (like lactation) are less directly connected, the dominant theme is immune-vascular interplay.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006953","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0045766","count":4}]},{"hash":"1155567680027478635","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019673","count":2},{"id":"GO:0009244","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0080110","count":2},{"id":"GO:0009242","count":2}]},{"hash":"1581186231548597113","title":"Proteostasis and Innate Immune Stress Response","description":"The cluster is driven by innate immune and stress-related processes: several terms point to innate immune response and response to dsRNA, while others emphasize proteostasis via chaperone-mediated folding and peptidyl-prolyl isomerization. The presence of non-motile cilium assembly and mitotic cycle suggests broader cell signaling and division context, but the dominant theme appears to be cellular stress responses linking protein folding with immune signaling.","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0043278","count":5},{"id":"GO:0006478","count":4},{"id":"GO:1903646","count":4},{"id":"GO:0071360","count":4},{"id":"GO:0070389","count":4}]},{"hash":"2238184535511413602","title":"Embryonic Morphogenesis and Neural Crest Development","description":"GO terms are dominated by embryogenesis and tissue morphogenesis, including neural crest migration, cranial skeleton morphogenesis, inner ear development, heart development, and brain regionalization. This points to a cluster of proteins involved in embryonic development and patterning, particularly neural crest\u2013driven craniofacial morphogenesis.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0048565","count":7},{"id":"GO:0090009","count":7},{"id":"GO:0048839","count":7},{"id":"GO:0007507","count":6}]},{"hash":"853059220221066199","title":"Vertebrate embryogenesis: transcriptional regulation and organ morphogenesis","description":"This cluster shows strong signals for transcription by RNA polymerase II and its negative regulation, alongside diverse organogenesis terms (brain segmentation, hindbrain rhombomere development, eye, heart, lung, pancreas morphogenesis). The common thread appears to be vertebrate embryonic development governed by transcriptional regulatory networks affecting multiple organs, rather than a single pathway.","confidence":"High","size":17,"edges":63,"triangles":57,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0000122","count":10},{"id":"GO:0035284","count":9},{"id":"GO:0021571","count":9},{"id":"GO:0002087","count":9}]},{"hash":"1434863211217364133","title":"Thermogenic Metabolism and GPCR Signaling","description":"The top GO terms cluster around energy metabolism and temperature-driven processes (diet-induced thermogenesis, cellular response to temperature), along with signaling pathways that regulate metabolism (adenylate cyclase-activating GPCR signaling) and core energy production (electron transport chain). There are also related vascular, immune, and xenobiotic response processes that often accompany metabolic adaptation. This points to a coherent theme of thermogenic energy metabolism with associated signaling rather than unrelated functions.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0019233","count":7},{"id":"GO:0010579","count":6},{"id":"GO:0022900","count":6}]},{"hash":"1556177788854640129","title":"Synaptic signaling and plasticity in sensory neurons","description":"This cluster centers on neural communication and learning, with strong representation of GABA and excitatory signaling, ion transport, receptor internalization, and regulation of long-term synaptic plasticity. The terms also connect to neuronal responsiveness to electrical stimuli and sensory system development (e.g., posterior lateral line), as well as behaviors like conditioned taste aversion and locomotion, all pointing to a cohesive theme of synaptic signaling and plasticity in sensory contexts.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001661","count":17},{"id":"GO:0071805","count":17},{"id":"GO:0007626","count":17},{"id":"GO:0060079","count":17},{"id":"GO:0007214","count":17}]},{"hash":"1629553186951484634","title":"Extrinsic and Mitochondrial Apoptosis Signaling","description":"The top GO terms are dominated by extrinsic apoptotic signaling via death domain receptors and related pathways, along with regulation of cytochrome c release from mitochondria, indicating apoptosis signaling with both extrinsic and mitochondrial involvement. A few terms (miRNA catabolic process, Rap signaling, intracellular transport) are less central to the cluster, but do not override the clear apoptosis theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010587","count":2},{"id":"GO:0032486","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0048149","count":2},{"id":"GO:0090200","count":1}]},{"hash":"2224759025865853522","title":"Neural Development and Synaptic Signaling","description":"The cluster is dominated by terms tied to neural development and neuron function, including heart development and Purkinje cell layer morphogenesis, as well as synaptic vesicle maturation and locomotion behavior. Regulatory processes like phosphorylation and transcription elongation control suggest developmental gene expression regulation, with a few metabolic terms being less central. Overall, it points to neural development and synaptic signaling.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0016188","count":2},{"id":"GO:0035641","count":2},{"id":"GO:0016310","count":2},{"id":"GO:2000134","count":2}]},{"hash":"1010349417090055526","title":"Unknown","description":"The terms show a mix of nucleotide metabolism, histone mRNA turnover, DNA-binding regulation, and signaling pathway regulation, with no clear single function linking them; plus some obsolete terms and small counts suggest noise rather than a cohesive theme.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0070584","count":2},{"id":"GO:0016310","count":2},{"id":"GO:1904251","count":2},{"id":"GO:0043388","count":2}]},{"hash":"1724269811687202845","title":"Proteoglycan biosynthesis and Hedgehog signaling","description":"Most terms point to glycosaminoglycan/proteoglycan biosynthesis (heparan sulfate, dermatan sulfate) and sulfation, and to Hedgehog signaling and segmentation (smoothened pathway, segment polarity). Together these imply extracellular matrix\u2013dependent modulation of developmental signaling and epithelial morphogenesis, with possible kidney-related contexts. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":2},{"id":"GO:0070294","count":2},{"id":"GO:0030205","count":1},{"id":"GO:0015015","count":1},{"id":"GO:0015012","count":1}]},{"hash":"2093788175497260863","title":"Environmental stimulus response and development","description":"This cluster centers on organismal responses to environmental cues\u2014pain perception, temperature and circadian responses, startle\u2014along with developmental processes (multicellular development, ossification) and related calcium signaling. The combination suggests a theme of environmental stimulus processing tied to developmental/metabolic functions, despite the diverse specific terms.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0043029","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0098703","count":3}]},{"hash":"1782534237408340073","title":"Metabolic biosynthesis and degradation of small molecules","description":"The top GO terms include diverse biosynthetic (biotin, PHB, strigolactone, antibiotic) and catabolic/redox processes (beta-ketoadipate, 3-phenylpropionate, chlorophyll catabolic, detoxification), suggesting a broad theme of small-molecule metabolism rather than a single specific pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0098869","count":9},{"id":"GO:0042952","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0015996","count":8},{"id":"GO:0055114","count":7}]},{"hash":"1423149017063359791","title":"Dendritic spine morphogenesis and actin remodeling","description":"The cluster is enriched for dendritic spine morphogenesis, actin cytoskeleton organization and polymerization, lamellipodium/ruffle assembly, and postsynaptic signaling (including BDNF response and excitatory postsynaptic potential regulation), pointing to neuronal spine development and actin-driven remodeling at synapses. A few terms relate to neuronal excitability, but the shared theme is spine- and actin-focused synaptic maturation.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":4},{"id":"GO:0030036","count":4},{"id":"GO:0035725","count":4},{"id":"GO:2000463","count":3},{"id":"GO:0070830","count":3}]},{"hash":"2215693127692905135","title":"Developmental ECM and connective tissue formation","description":"This cluster is enriched for terms related to extracellular matrix organization and tissue morphogenesis across multiple tissues (cartilage condensation, collagen fibril organization, endochondral ossification, skin development, glomerular basement membrane development, oviduct morphogenesis, and lymphangiogenesis), indicating a common theme of ECM-mediated developmental processes in connective tissues.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001502","count":5},{"id":"GO:0043588","count":5},{"id":"GO:0030199","count":4},{"id":"GO:2000478","count":4},{"id":"GO:0032836","count":4}]},{"hash":"508754853136243900","title":"Transmembrane Transporters","description":"The top GO terms are dominated by transmembrane transport across membranes for diverse substrates (sodium, nitrite/nitrate, phosphate, sialic acid, arabinose, xenobiotics, etc.), plus a term about neurotransmitter loading into synaptic vesicles. This points to a group of proteins primarily functioning as membrane transporters or transport-related components, possibly including vesicle-associated transport processes. Confidence: High","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0098700","count":3},{"id":"GO:0015707","count":3},{"id":"GO:0015751","count":3}]},{"hash":"452543713990966847","title":"Chemical Sensing and Taste Perception","description":"The top GO terms are dominated by chemosensory functions: pheromone response, chemical stimulus perception, taste and bitter taste detection, indicating a cluster centered on chemical sensing and taste perception. Other terms (development, thermogenesis, ERK signaling) are less central but do not outweigh the chemosensory theme.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":6},{"id":"GO:0007606","count":6},{"id":"GO:0050909","count":5},{"id":"GO:0001580","count":5},{"id":"GO:0007275","count":3}]},{"hash":"745153237864433130","title":"Brain Adrenergic-Dopaminergic Signaling","description":"The GO terms are dominated by brain-specific signaling related to adrenergic and dopaminergic neurotransmission, including MAPK- and phospholipase C-mediated pathways, regulation of synaptic plasticity (LTD), and brain renin-angiotensin involvement in blood pressure. This points to neuromodulatory signaling in the brain, centered on adrenergic/dopaminergic pathways, with some noise from unrelated immune-related terms. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":17},{"id":"GO:0001963","count":17},{"id":"GO:1900453","count":17},{"id":"GO:0001994","count":17},{"id":"GO:0071883","count":17}]},{"hash":"626061728500955477","title":"Transcription Regulators with Immune Modulation","description":"The cluster\u2019s terms cluster around transcription regulation (negative regulation of transcription by RNA polymerase II; DNA-templated transcription) and immune signaling (negative regulation of T cell apoptotic process; positive regulation of T cell tolerance induction; IL-12 production), with additional hormone-responsive and protein stabilization terms (lactation; response to dehydroepiandrosterone and 11-deoxycorticosterone; protein stabilization). This suggests proteins that function as transcriptional regulators intertwined with immune modulation and hormonal responsiveness, rather than a single narrow function. The lack of edges implies diversity, but the shared emphasis on transcription control and immune/hormonal signaling provides a plausible organizing theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007595","count":1},{"id":"GO:1903494","count":1},{"id":"GO:0050821","count":1}]},{"hash":"457438290078380558","title":"Unknown","description":"The GO terms span diverse processes from RNA processing and transcription to spermatogenesis, signaling, genome maintenance, viral assembly, and host-symbiont interactions, with no clear shared function tying the proteins together. Therefore no cohesive theme; label Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0090286","count":2},{"id":"GO:0090342","count":1}]},{"hash":"1624038571030098427","title":"Epigenetic and Transcriptional Regulation in Development","description":"This cluster centers on transcriptional control (DNA-templated transcription and regulation of transcription by RNA Pol II) and chromatin/epigenetic modifiers (DNA methylation, histone H3-K36 dimethylation), alongside development-related processes (uterus development, uterine gland development, embryonic hematopoiesis, T cell differentiation). The convergence of transcriptional regulation with epigenetic marks and developmental processes suggests a cohesive role in controlling gene expression during development.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0010216","count":3},{"id":"GO:0045582","count":2},{"id":"GO:0060065","count":2}]},{"hash":"2193909814575271928","title":"Ribosome Biogenesis and Cell Division","description":"The cluster is dominated by GO terms tied to ribosome assembly and function (ribosomal subunit export, ribosomal small subunit biogenesis, cytoplasmic translation, tRNA modification) and cell division (cell cycle, cell septum assembly), suggesting a cohesive role in coordinating ribosome production with bacterial cell division. A few terms for stress responses and conjugation are present but less central to the core theme.","confidence":"High","size":16,"edges":31,"triangles":6,"max_degree":8,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":16},{"id":"GO:0000055","count":15},{"id":"GO:0007049","count":14},{"id":"GO:1901001","count":11},{"id":"GO:0090529","count":11}]},{"hash":"468393838321335209","title":"Neural development and cell fate specification","description":"The top GO terms point to transcriptional control (RNA polymerase II) and multiple neural lineage outcomes, including spinal cord motor neuron specification, GABAergic interneuron differentiation in the cortex, and oligodendrocyte fate, with supportive signals from calcium signaling and broader developmental contexts like subpallium/cortex patterning and organogenesis. This suggests a cohesive theme of CNS neural development and cell fate specification, despite some peripheral developmental terms.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0071277","count":7},{"id":"GO:0035470","count":7},{"id":"GO:0036091","count":7},{"id":"GO:0031018","count":6}]},{"hash":"913508692563280454","title":"Signaling and Developmental Cues","description":"The cluster includes GO terms tied to development (angiogenesis, cardiac neural crest\u2013related heart development) and core signaling processes (MAPKK activity, spindle assembly regulation, apoptotic signaling), suggesting a broad theme of signaling pathways guiding growth and cell fate. Some outliers (biofilm formation, dsRNA/muramyl peptide responses) are present but don\u2019t dominate the theme, so a developmental-signaling label fits best overall.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":16},{"id":"GO:0090606","count":16},{"id":"GO:0000186","count":16},{"id":"GO:0061308","count":16},{"id":"GO:0001525","count":16}]},{"hash":"1113899972857463053","title":"TLR-NF-\u03baB Innate Immune Signaling","description":"The cluster centers on TLR pathways (TLR4, TLR9), LPS response, and NF-\u03baB signaling regulation (both positive and negative), with neutrophil chemotaxis, pointing to a cohesive innate immune/inflammatory program. While there are outliers related to fat cell and foam cell differentiation, the dominant theme is toll-like receptor\u2013driven NF-\u03baB\u2013mediated inflammatory signaling and neutrophil recruitment.","confidence":"High","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045598","count":4},{"id":"GO:0030593","count":3},{"id":"GO:0010745","count":3},{"id":"GO:0043124","count":3},{"id":"GO:0034162","count":3}]},{"hash":"264509200950114288","title":"Telomere maintenance regulation and PARP signaling","description":"This cluster is dominated by GO terms about telomere maintenance, capping, and telomeric DNA binding, including positive/negative regulation via telomerase and telomere lengthening, along with protein poly-ADP-ribosylation and auto-ADP-ribosylation. These points suggest a cohesive theme around telomere biology and PARP-related post-translational modifications, with a broader signaling backdrop (e.g., Wnt/synaptic terms) that is secondary to the core telomere-PARP relationship.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0070212","count":3},{"id":"GO:1904355","count":3},{"id":"GO:1900383","count":3},{"id":"GO:1904357","count":3}]},{"hash":"1704802747279494000","title":"Cardiac electrophysiology and calcium signaling","description":"The strongest signals are about cardiac muscle electrical activity and ion transport, including regulation of atrial depolarization, Purkinje-to-ventricular signaling, and calcium ion import. Additional terms touch on cardiovascular-related processes (aldosterone biosynthesis, endothelial remodeling), while temperature/pain terms are more peripheral noise. Overall, the cluster centers on heart electrophysiology and calcium homeostasis.","confidence":"Medium","size":16,"edges":19,"triangles":5,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0006828","count":8},{"id":"GO:0098703","count":8}]},{"hash":"2009336581215060838","title":"Ribosome Biogenesis and Cell Growth","description":"The top GO terms cluster tightly around ribosome assembly and function (ribosome biogenesis, cytoplasmic translation, ribosomal subunit export from nucleus, tRNA modification) along with cell cycle processes (cell division, cell cycle, cell septum assembly). This indicates a coherent theme of producing and employing ribosomes to support cell growth and division, with only a background layer of stress-response terms. Therefore, the label reflects the dominant function of the cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0051301","count":12},{"id":"GO:0000055","count":11},{"id":"GO:1901001","count":10},{"id":"GO:0090529","count":10},{"id":"GO:0042274","count":10}]},{"hash":"1568925790669881524","title":"Unknown","description":"The terms span DNA repair, nervous system and heart development, angiogenesis, exocytosis regulation, focal adhesion assembly, dsRNA response, and other processes, with no single dominant function tying them together. This heterogeneity makes a cohesive, specific label unsupported.","confidence":"","size":16,"edges":9,"triangles":3,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":13},{"id":"GO:0045956","count":12},{"id":"GO:0007399","count":12},{"id":"GO:0051893","count":12},{"id":"GO:0033129","count":11}]},{"hash":"1364828279571834858","title":"Mitochondrial Metabolite Transport and Membrane Dynamics","description":"The cluster centers on transport of multiple metabolites across membranes (NAD, ornithine, glycine, thiamine pyrophosphate, deoxynucleotides) and on mitochondrial membrane processes (fission, permeability regulation), with supporting signals related to amino acid starvation and cell-survival pathways. This points to a cohesive theme of mitochondrial metabolite transport coupled with membrane remodeling and integrity.","confidence":"High","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035352","count":14},{"id":"GO:0034198","count":14},{"id":"GO:0000066","count":14},{"id":"GO:0097421","count":14},{"id":"GO:0036233","count":14}]},{"hash":"1956964933118516047","title":"Developmental Angiogenesis and Immune-Apoptotic Signaling","description":"The terms cluster around multicellular development and sprouting angiogenesis, plus immune/inflammatory responses (LPS response, inflammatory response, B cell immunity) and apoptosis pathways (extrinsic apoptosis, AICD, motor neuron apoptosis). This pattern suggests a developmental program where vascular remodeling is coordinated with immunity and programmed cell death, with mechanosensing involvement.","confidence":"High","size":16,"edges":22,"triangles":8,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007275","count":14},{"id":"GO:1903588","count":14},{"id":"GO:0071260","count":14},{"id":"GO:0032496","count":14},{"id":"GO:0006954","count":14}]},{"hash":"1220873263844190129","title":"Cerebellar development and Bergmann glia differentiation","description":"This cluster shows strong enrichment for neural development terms, notably cerebellar cortex formation and Bergmann glial cell differentiation, with supporting terms such as axon regeneration, indicating a coherent theme of cerebellar neural development and glial maturation. Some terms (e.g., insulin receptor signaling and T cell receptor signaling) are general signaling pathways that can appear in many tissues, but they do not override the neural-development emphasis.","confidence":"Medium","size":16,"edges":90,"triangles":259,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":15},{"id":"GO:0050852","count":15},{"id":"GO:2001275","count":15},{"id":"GO:0008285","count":15},{"id":"GO:0045736","count":15}]},{"hash":"1190907786196037875","title":"Developmental remodeling and angiogenesis","description":"This cluster is enriched for terms tied to tissue remodeling, extracellular matrix disassembly, and angiogenesis, including endothelial barrier establishment and general development processes, suggesting a theme of development-associated matrix remodeling and vascular formation rather than a single pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":5},{"id":"GO:0045766","count":5},{"id":"GO:0007586","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0022617","count":4}]},{"hash":"1204716784919673370","title":"Golgi-ER Vesicle Trafficking","description":"This cluster is dominated by GO terms for ER-to-Golgi and intra-Golgi vesicle transport, ER and Golgi membrane fusion, Golgi ribbon formation, and related vesicle fusion processes, indicating a core function in Golgi-ER trafficking and Golgi organization. A synaptic potentiation term appears less central and may reflect neuron-specific vesicle dynamics, but the main theme is ER\u2013Golgi transport and fusion.","confidence":"High","size":16,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048280","count":5},{"id":"GO:0060291","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0016320","count":3},{"id":"GO:0006891","count":3}]},{"hash":"618080992501870424","title":"Ubiquitin-Driven Protein Degradation and Antiviral Signaling","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolism (ERAD, ubiquitination, autoubiquitination, sumoylation) and immune-related pathways (innate immune response, defense against virus, TNF signaling). The common thread is proteins involved in tagging and degrading other proteins while coordinating innate immune and antiviral signaling, making this a coherent degradation- and signaling-focused module.","confidence":"High","size":16,"edges":32,"triangles":42,"max_degree":9,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":10},{"id":"GO:0042787","count":10},{"id":"GO:0045087","count":8},{"id":"GO:0051607","count":8},{"id":"GO:0051865","count":7}]},{"hash":"971174911453486768","title":"GPCR-driven cAMP/cGMP signaling","description":"This cluster centers on GPCR-mediated signaling leading to the biosynthesis of cyclic nucleotides: adenylate cyclase activation and subsequent cAMP production, as well as cGMP biosynthesis. The top GO terms include adenylate cyclase-activating receptor signaling, GPCR adenosine receptor signaling, and cAMP/cGMP biosynthetic processes, along with intracellular signal transduction and downstream responses such as blue light signaling and cellular responses to forskolin. The convergence on these second messenger pathways, plus contextual cues from light and hypoxia sensing, supports a cohesive GPCR-cAMP/cGMP signaling theme. ","confidence":"High","size":16,"edges":17,"triangles":7,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0071880","count":13},{"id":"GO:0035556","count":12},{"id":"GO:0006171","count":12},{"id":"GO:0070483","count":12},{"id":"GO:1904322","count":12}]},{"hash":"702235037327438217","title":"Chromatin-Linked Developmental Regulation","description":"This cluster combines chromatin-related processes (nucleosome assembly, transcriptional regulation, histone marks) with diverse developmental programs (neural retina, left-right patterning, placenta/embryo differentiation, endocrine and pancreatic development), suggesting proteins that coordinate gene expression during development via chromatin regulation.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0006334","count":3},{"id":"GO:0031397","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0003407","count":2}]},{"hash":"1200589860874965723","title":"Unknown","description":"The cluster\u2019s GO terms show a broad mix: innate immune response and signaling terms appear, but also apoptosis, memory, various metabolic and structural processes. No single cohesive function ties all proteins together, so there isn\u2019t a reliable, interpretable label beyond Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0007613","count":2},{"id":"GO:0060168","count":2}]},{"hash":"2214390560205000658","title":"Glutamatergic Synapse Assembly and Regulation","description":"The terms point to synapse formation and function in excitatory neurons: organization of synapses, NMDA receptor activity regulation, postsynaptic density (PSD95) clustering, presynaptic membrane assembly, and enhanced glutamatergic transmission. Receptor recycling and diacylglycerol signaling further modulate synaptic strength, with amyloid precursor protein metabolism linked to neuronal signaling. The retina development term may reflect neural development contexts but the dominant theme is glutamatergic synapse structure and signaling.","confidence":"High","size":16,"edges":116,"triangles":506,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":6},{"id":"GO:0050808","count":4},{"id":"GO:0002087","count":4},{"id":"GO:0042982","count":4},{"id":"GO:2000310","count":4}]},{"hash":"572993389799012868","title":"Craniofacial bone and cartilage development","description":"This cluster\u2019s top GO terms cluster around craniofacial and skeletal tissue differentiation: osteoblast differentiation, palatal roof development, neural crest differentiation, skeletal muscle differentiation, and cartilage development (trachea), along with transcriptional regulation. This points to coordinated programs driving craniofacial bone/cartilage formation and related skeletal differentiation.","confidence":"High","size":16,"edges":100,"triangles":337,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0045669","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0006366","count":6},{"id":"GO:2001016","count":5}]},{"hash":"1122881186598264200","title":"Neuronal endosome trafficking and signaling","description":"The top terms emphasize nervous system development and axon guidance (Roundabout pathway) alongside endocytosis, multivesicular body assembly, and endosome-to-lysosome transport, plus protein localization to endosomes and phospholipid homeostasis. This combination points to a cohesive role for endosome-mediated receptor trafficking in neuronal signaling and development (e.g., ROBO-dependent guidance), with broader signaling components also captured by shared terms like T cell receptor signaling. Overall, the core theme is neuronal development governed by endosomal trafficking and vesicle maturation.","confidence":"High","size":16,"edges":100,"triangles":327,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0035385","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0006897","count":4},{"id":"GO:0010796","count":3}]},{"hash":"307737682993514353","title":"Developmental morphogenesis: synapse and ECM organization","description":"The cluster is enriched for neural development and synapse-related terms (dendritic spine morphogenesis, vestibular receptor morphogenesis, synapse organization) along with extracellular matrix and tissue structuring processes (collagen fibril organization, slit diaphragm assembly, angiogenesis). This suggests a cohesive developmental program coordinating morphogenesis across tissues with synaptic formation and ECM remodeling as central themes.","confidence":"High","size":16,"edges":113,"triangles":469,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060997","count":9},{"id":"GO:0030199","count":8},{"id":"GO:0060116","count":8},{"id":"GO:1904237","count":8},{"id":"GO:0055072","count":8}]},{"hash":"1029751119214425119","title":"Neurodevelopment and Membrane Signaling","description":"This cluster is enriched for nervous system and brain development terms (nervous system development, brain development) and organogenesis processes (angiogenesis, kidney development), suggesting a broader developmental role. The accompanying membrane-related terms (plasma membrane repair, phosphatidylinositol-mediated signaling, regulation of synaptic vesicle exocytosis, Smoothened signaling pathway) indicate coupling of membrane signaling and trafficking with developmental processes, supporting a cohesive theme of developmental signaling with neural/vascular emphasis.","confidence":"Medium","size":16,"edges":111,"triangles":444,"max_degree":15,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0001778","count":5},{"id":"GO:0001525","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0010796","count":4}]},{"hash":"1495706833253714373","title":"Immune regulation and cytokine signaling","description":"The cluster is dominated by GO terms describing immune system modulation and cytokine production, including negative regulation of NK cell cytotoxicity, positive regulation of B cell activation, IL-2 production, cytokine production in immune response, NK cell tolerance, T cell activation regulation, and type II interferon production. Detection of peptidoglycan suggests innate sensing. While a couple of terms relate to neurons and cardiac depolarization as outliers, the overall theme is immune signaling and regulation, so this label fits well.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":16},{"id":"GO:0050871","count":16},{"id":"GO:1900042","count":16},{"id":"GO:0032499","count":16},{"id":"GO:0060371","count":16}]},{"hash":"1635873184938634949","title":"Actin Dynamics in Muscle and Lymphocytes","description":"This cluster is dominated by GO terms for actin filament dynamics (severing, polymerization, movement) and Arp2/3-mediated nucleation, with supporting terms on skeletal muscle fiber development and lymphocyte migration/antigen presentation. The common thread is actin cytoskeleton remodeling in both muscle cells and immune cells, uniting these functions under a single theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":2},{"id":"GO:0051014","count":2},{"id":"GO:0030041","count":2},{"id":"GO:0002625","count":2},{"id":"GO:2000402","count":2}]},{"hash":"697568595856240668","title":"Lipid metabolism and cholesterol homeostasis","description":"Most top GO terms cluster around lipid handling: triglyceride homeostasis, triglyceride catabolic process, HDL particle remodeling, and cholesterol homeostasis, indicating the proteins function in lipid metabolism and lipoprotein management. A few non-lipid terms appear but are minority, suggesting peripheral roles or annotation noise.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086091","count":2},{"id":"GO:0070328","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0034375","count":2},{"id":"GO:0042632","count":2}]},{"hash":"990505397903781555","title":"Immune signaling and cell cycle regulation","description":"The GO terms cluster around immune processes (neutrophil chemotaxis, defense response to virus, T cell receptor signaling, responses to cytokines CSF stimuli) and also include mitotic cell cycle and cell division, suggesting proteins involved in both immune signaling and cell cycle control rather than a single pathway. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030593","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0071560","count":2}]},{"hash":"1781162182789327575","title":"Rho GTPase signaling in synaptic trafficking","description":"Top GO terms indicate coordination between Rho-family GTPase regulation and synaptic vesicle dynamics (docking, LTP, EPSP), with supporting intracellular transport roles (ER\u2013Golgi, vesicle transport). This suggests a cluster of proteins that regulate GTPase signaling to control vesicle trafficking and synaptic plasticity.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0016081","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0032258","count":3}]},{"hash":"816828978849833947","title":"Immune-regulatory signaling with glucocorticoid response","description":"This cluster centers on immune modulation and anti-inflammatory signaling, highlighted by defense response to protozoan, negative regulation of IL-6 and IFN production, and a glucocorticoid response. It also includes PI3K/AKT pathway regulation and endothelial survival, suggesting coordinated signaling that ties immune control to vascular and neural contexts.  ","confidence":"Medium","size":16,"edges":108,"triangles":407,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0042832","count":4},{"id":"GO:0032715","count":3},{"id":"GO:0032689","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0034115","count":3}]},{"hash":"826736366019138260","title":"Cartilage and Skeletal Development","description":"The cluster is enriched for GO terms related to skeletal system development, cartilage condensation, collagen fibril organization, and hyaluronan catabolic process, indicating a shared role in cartilage/bone formation and extracellular matrix remodeling. Additional terms like establishment of the blood-nerve barrier and hippocampus development appear less central but may reflect broader developmental contexts. Overall, the dominant pattern points to cartilage and skeletal development.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021766","count":10},{"id":"GO:0050728","count":10},{"id":"GO:0030199","count":9},{"id":"GO:1900625","count":9},{"id":"GO:0001502","count":9}]},{"hash":"1736723954101130897","title":"Cell Signaling and Developmental Processes","description":"The top GO terms span neural signaling (synaptic vesicle maturation, axon extension), metabolic signaling (insulin response, phosphatidylinositol dephosphorylation, GTPase regulation), and immune/hematopoietic processes (neutrophil chemotaxis, hemopoiesis, somatic stem cell maintenance). This broad mix points to a general theme of signaling and developmental regulation across different tissues rather than a single, cohesive pathway, so a broad \u201ccell signaling and developmental processes\u201d label is most appropriate.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016188","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0007343","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0043087","count":2}]},{"hash":"897002910768162459","title":"Axon Guidance and Neural Development","description":"The top GO terms point to neural development and axon pathfinding, notably semaphorin-plexin signaling, chemorepulsion of branchiomotor axons, facial nerve structure, and anterior commissure morphogenesis, suggesting a common theme of neural patterning and connectivity; regulatory transcription-related terms and a few broader developmental terms (like adipose development) are likely supporting or indirect annotations.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:1902287","count":1},{"id":"GO:2000305","count":1},{"id":"GO:2000535","count":1},{"id":"GO:0001709","count":1}]},{"hash":"1945847177595958287","title":"Multi-tissue regulatory signaling and remodeling","description":"GO terms indicate modulation across bone, extracellular matrix, neural, immune, and vascular processes (e.g., osteoclast regulation, collagen organization, neuronal plasticity, apoptotic signaling, complement, and angiogenesis). The common thread is broad regulatory signaling that governs tissue remodeling and cross-talk between pathways, rather than a single specific function.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045671","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0048169","count":2},{"id":"GO:1902042","count":2}]},{"hash":"284725294455775449","title":"Growth factor signaling and cytoskeleton regulation","description":"This cluster is enriched for GO terms tied to growth factor signaling pathways (insulin-like growth factor receptor signaling; BMP signaling) and to cytoskeletal dynamics (actin cytoskeleton organization; small GTPase\u2013mediated signaling; regulation of GTPase activity). Together, these suggest a functional module centered on receptor-driven signaling that orchestrates cytoskeletal remodeling, influencing cell behavior; some immune-related terms are present but do not define the core theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048009","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0043314","count":2}]},{"hash":"1734814947451063799","title":"Cardiovascular development and Rho/Rac-mediated actin remodeling","description":"The cluster shows strong representation of heart and blood vessel development terms, along with Rho/Rac signaling and actin cytoskeleton dynamics (lamellipodium assembly, cell spreading, cytoskeleton organization), suggesting a coordinated program linking cardiovascular development to cytoskeletal remodeling and cell migration.","confidence":"High","size":16,"edges":24,"triangles":1,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0008286","count":13},{"id":"GO:0007264","count":13},{"id":"GO:0032287","count":13},{"id":"GO:0035023","count":13}]},{"hash":"53467460382580400","title":"Ubiquitin-dependent mitotic regulation","description":"It centers on ubiquitin-related processes and cell cycle control, with multiple terms for ubiquitination and mitotic cell cycle, suggesting proteins that modulate protein turnover during division. The presence of signaling terms (small GTPase signaling, GPCR pathways, growth hormone signaling) and apoptotic regulation indicates broader regulation of cell fate via ubiquitin-dependent pathways.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0030845","count":4},{"id":"GO:0030433","count":3}]},{"hash":"241835343594597168","title":"Wnt-driven developmental transcription regulation","description":"This cluster centers on Wnt signaling and its role in regulating transcription during development (GO:0016055, GO:0030177, GO:0006355), with supporting signals from Rho pathway regulation (GO:0035023) and development-related processes (GO:0007275, GO:0051321, GO:0007276). The combination suggests coordinated control of gene expression and signaling guiding multicellular development, possibly including germline-related processes, with occasional chromatin/transcription machinery hints (GO:0016569, GO:0009303). Confidence reflects a coherent, if broad, developmental regulatory theme.","confidence":"Medium","size":16,"edges":10,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030177","count":4},{"id":"GO:0006355","count":4},{"id":"GO:0045087","count":3},{"id":"GO:0051321","count":3}]},{"hash":"1584576580625045212","title":"Histone methylation and chromatin silencing","description":"This cluster centers on histone methylation marks (H3K4, H3K9, H3K27, H4K20) and heterochromatin formation (e.g., rDNA heterochromatin), indicating a cohesive theme of chromatin modification and transcriptional silencing. Obsolete GO terms appear but do not alter the core function represented. ","confidence":"High","size":16,"edges":45,"triangles":20,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":2},{"id":"GO:1900477","count":2},{"id":"GO:1902231","count":2},{"id":"GO:0034773","count":2},{"id":"GO:0098532","count":2}]},{"hash":"812976743687684126","title":"RNA processing and translation regulation","description":"The cluster centers on mRNA maturation (splicing via the spliceosome, mRNA export, polyadenylation) and translation control (formation of the translation preinitiation complex, translation initiation/reinitiation, ribosome biogenesis). These GO terms together point to proteins involved in RNA lifecycle from processing to the start of translation, justifying a label that spans RNA processing and translation regulation.","confidence":"High","size":16,"edges":17,"triangles":11,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0001731","count":3}]},{"hash":"190398776067824466","title":"BMP and Integrin Signaling in ECM Remodeling and Immunity","description":"The top GO terms cluster around integrin-mediated signaling, collagen fibril organization, BMP-responsive signaling, and immune-related processes (T cell chemotaxis, macrophage fusion), suggesting a module where extracellular matrix interactions and growth-factor\u2013driven signaling regulate tissue remodeling and immune cell coordination. While terms like ovulation and myelination appear, the prevailing theme is signaling at ECM interfaces that modulates immune responses and remodeling activities, rather than a single isolated function. Therefore, this name captures the core shared function of the cluster: BMP- and integrin-mediated signaling in ECM remodeling and immunity.","confidence":"Medium","size":16,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001542","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0071773","count":2}]},{"hash":"195372538020338281","title":"Renal morphogenesis with innate immune signaling","description":"Dominant kidney development terms (mesonephric duct and proximal/distal tubule morphogenesis) point to renal morphogenesis, while several immune-related terms (Fc-gamma receptor signaling, complement lectin pathway, NK cell chemotaxis regulation) and vascular morphogenesis terms suggest concurrent involvement of immune signaling in organogenesis. Overall, the cluster centers on nephrogenesis with immune signaling connections.","confidence":"Medium","size":16,"edges":114,"triangles":481,"max_degree":15,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0072177","count":16},{"id":"GO:0038094","count":16},{"id":"GO:0072287","count":16},{"id":"GO:2000502","count":16},{"id":"GO:0071226","count":16}]},{"hash":"1949893588285496222","title":"T-cell development and immune signaling","description":"The GO terms point to thymus development, adaptive immune response, and IL-2 production, all hallmarks of T-cell\u2013related biology. Additionally, regulators of JNK and Wnt signaling, GTPase activity, and TGF-beta\u2013responsive processes align with signaling events driving T-cell development and activation. The cluster\u2019s theme is best captured as T-cell development and immune signaling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0050731","count":3}]},{"hash":"956268669211697125","title":"Lipid Metabolism and Adipogenesis","description":"The main signals are lipid-centric: monounsaturated fatty acid biosynthesis, sphingosine biosynthetic process, response to fatty acid, cholesterol esterification, and white fat cell differentiation, suggesting a cluster focused on lipid production and adipocyte formation. Some terms are historical or less central (obsolete GO entries, photoinhibition or tarsal gland development), but the dominant theme remains lipid metabolism and adipogenesis across species.","confidence":"High","size":16,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:1903966","count":3},{"id":"GO:0044130","count":3},{"id":"GO:0070542","count":3},{"id":"GO:0046512","count":3}]},{"hash":"393239141665746333","title":"Sperm maturation and energy metabolism","description":"The cluster shows strong signals for glycolytic process and TCA cycle, indicating central energy metabolism, along with a sperm capacitation term, which links to germ cell maturation. Additional amino acid catabolism terms (L-alanine and L-leucine) support energy supply, while immune/xenobiotic response terms appear secondary. Overall, the cohesive theme is energy production related to germ cell maturation, hence this label. ","confidence":"Medium","size":16,"edges":101,"triangles":340,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:2000648","count":7},{"id":"GO:0006096","count":6},{"id":"GO:0032496","count":6},{"id":"GO:0042853","count":5}]},{"hash":"1964292171304577742","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around ribosome production and protein synthesis, including translation, ribosome biogenesis (overall and small subunit), translational initiation, rRNA maturation, and tRNA modification. A few cell-cycle terms may reflect growth coordination with ribosome assembly, but the dominant signal is ribosome assembly and active translation.","confidence":"High","size":16,"edges":34,"triangles":30,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0042254","count":4},{"id":"GO:0006413","count":3},{"id":"GO:0000082","count":2},{"id":"GO:1901001","count":2}]},{"hash":"2106833187725899107","title":"Ribosome biogenesis and mRNA export","description":"The cluster is dominated by terms tied to translation and ribosome assembly (GO:0006412; GO:0000027; GO:0000028) and to mRNA processing/export (GO:0016973; GO:0006406), with additional signals of mRNA stabilization and miRNA-mediated translational control. This suggests a cohesive set of proteins involved in ribosome biogenesis, translation, and post-transcriptional mRNA handling/export pathways.","confidence":"High","size":16,"edges":34,"triangles":66,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000027","count":4},{"id":"GO:0016973","count":3},{"id":"GO:0051096","count":3},{"id":"GO:0032781","count":3}]},{"hash":"750206351225909283","title":"Neurodevelopment and Immune Signaling","description":"The top GO terms point to neural development and synaptic function (multicellular organism development, nervous system development, transmission of nerve impulse, synapse organization, sensory perception of sound), suggesting a core theme of neural development. At the same time, immune-related terms (cytokine production, interleukin-2 production, NK cell cytotoxicity regulation, hypersensitivity) indicate immune signaling components co-occurring in the cluster. Together, the proteins seem to participate in neural development with accompanying immune modulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0050910","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0019226","count":5}]},{"hash":"1683641109962497938","title":"Adaptive immune activation and regulation","description":"This cluster is dominated by immune-related GO terms: complement activation (classical pathway), immunoglobulin production, B cell activation, cytokine production (e.g., IL-2), and NK cell regulation, indicating an adaptive immune response and its modulation. Some non-immune terms appear (neuronal guidance, cardiac depolarization) but are likely incidental.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":9},{"id":"GO:0002377","count":8},{"id":"GO:0007157","count":8},{"id":"GO:0002859","count":7},{"id":"GO:0050871","count":7}]},{"hash":"999186589209188871","title":"Endothelial Mechanotransduction and Vascular Signaling","description":"The top GO terms center on endothelial and vascular biology: cellular response to mechanical stimulus, nitric oxide biosynthesis, regulation of endothelial cell apoptosis, blood coagulation, and TGF-beta production, all pointing to endothelial signaling and responses to mechanical cues. Some outliers (antibiotic-related processes and PHB biosynthesis) may reflect annotation noise or cross-species annotations, but the dominant theme supports a vascular/mechanotransduction cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0045429","count":3},{"id":"GO:1902219","count":3},{"id":"GO:2000352","count":3}]},{"hash":"1679406494518684297","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":40,"triangles":40,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0030205","count":8},{"id":"GO:0015015","count":8},{"id":"GO:0015012","count":8},{"id":"GO:0006477","count":8},{"id":"GO:0030206","count":8}]},{"hash":"2300147750399379844","title":"Thermal and Pain Response with Tissue Development","description":"Reasoning: The top GO terms show strong enrichment for temperature-related responses (diet-induced thermogenesis, cellular response to temperature stimulus) and pain perception, indicating a thermo-sensory theme. Additional terms related to tissue development and secretion (skin, retina, saliva) and other physiological processes (blood coagulation, xenobiotic response) suggest broader tissue/organismal contexts. The combination supports a label centered on thermal/pain responsiveness with developmental tissue associations.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0019233","count":11},{"id":"GO:0046541","count":8},{"id":"GO:0042493","count":7}]},{"hash":"2092770239540472171","title":"Developmental transcription regulators","description":"The cluster is centered on RNA polymerase II\u2013mediated transcription and its positive regulation, with multiple genes linked to embryonic organ development (eye morphogenesis, heart development) and hindbrain patterning (brain segmentation, rhombomere development). These consistent transcriptional control terms, plus related stress-response transcription (PERK-mediated UPR), suggest a coherent group of transcription regulators driving developmental programs.","confidence":"High","size":16,"edges":105,"triangles":386,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0045944","count":7},{"id":"GO:0006366","count":7},{"id":"GO:0045872","count":6},{"id":"GO:0048048","count":6}]},{"hash":"1036407156724753995","title":"Inflammation, complement activation, and coagulation","description":"These proteins are enriched for GO terms tied to innate immune signaling (response to lipopolysaccharide) and innate defense pathways (classical and lectin complement activation), along with coagulation and remodeling of the extracellular matrix (collagen catabolic process, biomineral tissue development). The combination of inflammatory signaling, complement cascades, and coagulation, plus ECM remodeling, suggests a cohesive theme of inflammation-associated coagulation and tissue remodeling, even though the network edges are not connected. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":5},{"id":"GO:0006915","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1212326911274716677","title":"Ubiquitin-regulated TNF/NF-kappaB Immune Signaling","description":"The cluster is dominated by ubiquitination-related terms (K63- and K6-linked ubiquitination, autoubiquitination, ubiquitin-dependent ERAD) and by regulation of NF-kappaB and TNF signaling, along with adaptive immune response. This points to a cohesive module where ubiquitin modifications control inflammatory and immune signaling pathways.","confidence":"High","size":16,"edges":17,"triangles":0,"max_degree":9,"top_function":"autophagy","top_go_terms":[{"id":"GO:0030433","count":10},{"id":"GO:0051865","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0085020","count":10},{"id":"GO:0070534","count":10}]},{"hash":"148315379005757612","title":"Vertebrate Eye Development and Retinal Morphogenesis","description":"The top GO terms cluster around eye formation and retina development (embryonic eye morphogenesis, camera-type eye development, retina development, neural crest involvement) with broader development terms and transcription by RNA polymerase II, suggesting a cohesive set of proteins coordinating vertebrate eye/retina formation and its transcriptional regulation.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0006366","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0060441","count":5}]},{"hash":"1020977703957456839","title":"ECM Remodeling and Development","description":"The cluster is driven by terms like extracellular matrix disassembly, tissue remodeling, and multicellular growth, with supporting processes in amelogenesis and endothelial barrier establishment, plus midbrain development. Immune-related responses and digestion appear but do not override the core theme; overall these proteins seem to participate in tissue shaping and barrier formation during development, rather than a single specific pathway.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0030901","count":12},{"id":"GO:0032496","count":10},{"id":"GO:0007586","count":9},{"id":"GO:0035264","count":9}]},{"hash":"1501377735357579494","title":"GPCR-cAMP Neuropeptide Signaling and Thermogenesis","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling, neuropeptide signaling, and ERK cascade, with links to thermogenesis and metabolic regulation (diet-induced thermogenesis, cellular response to temperature, blood pressure). This points to a cohesive theme of GPCR-mediated signaling that modulates energy metabolism, vascular function, and neuropeptide pathways. Confidence: High","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0035025","count":11},{"id":"GO:0007218","count":9}]},{"hash":"159980354200057940","title":"Brain Adrenergic Signaling and Thermogenesis","description":"This cluster is dominated by terms related to adrenergic signaling and temperature-driven processes, including diet-induced thermogenesis, cellular responses to temperature, and norepinephrine-epinephrine\u2013mediated vasoconstriction. The presence of dopaminergic synaptic transmission and MAPK-activating adrenergic receptor signaling supports a brain-wide theme of sympathetic signaling influencing thermogenesis, blood pressure regulation, and neural communication. One outlier (thymocyte differentiation) is not aligned with this theme, but the core signal is still coherent. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0019233","count":8},{"id":"GO:0002035","count":6},{"id":"GO:0001963","count":6}]},{"hash":"441719093344539896","title":"Hair Keratinization and Hair Cycle","description":"Top GO terms show strong representation for keratinization and hair cycle, each with 16 proteins, implying a cluster of hair shaft structural proteins and hair follicle biology involved in keratin-based barrier formation and hair cycling.","confidence":"High","size":16,"edges":118,"triangles":533,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":16},{"id":"GO:0042633","count":16}]},{"hash":"120717448551988673","title":"Dopaminergic Visual and Sensory Neural Signaling","description":"Many top GO terms converge on neural signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, and modulation of signaling pathways (ERK cascade) linked to plasticity. Although a few terms touch on development or non-neural systems (heart development, brain RAS), the core cluster centers on neural response to stimuli and reward-related signaling, including responses to cocaine and prostaglandin stimuli, and pain perception.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":8},{"id":"GO:0070374","count":8},{"id":"GO:0001963","count":8},{"id":"GO:0048148","count":8},{"id":"GO:0071380","count":8}]},{"hash":"1825828035216934229","title":"Hair Keratinization and Hair Cycle","description":"The cluster is strongly enriched for keratinization and hair cycle terms, suggesting proteins involved in hair follicle structure and epidermal differentiation; the few secondary terms (spliceosome changes and lithium response) are much less represented and likely incidental.","confidence":"High","size":16,"edges":108,"triangles":426,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":7},{"id":"GO:0042633","count":7},{"id":"GO:0010226","count":1},{"id":"GO:0000388","count":1}]},{"hash":"654798014697111589","title":"B cell signaling and immune activation","description":"Most of the top GO terms are immune-related: B cell receptor signaling, adaptive and innate immune responses, and positive regulation of IL-2 production. These indicate a cluster of proteins involved in immune activation and signaling, particularly B cell\u2013mediated pathways. Some non-immune terms appear but are much less represented, so the core theme remains immune system signaling.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050853","count":14},{"id":"GO:0010765","count":14},{"id":"GO:0045087","count":14},{"id":"GO:0043552","count":13},{"id":"GO:1900042","count":12}]},{"hash":"806926094617589209","title":"Wnt signaling and ECM remodeling in development","description":"This cluster centers on developmental processes and extracellular matrix dynamics: midbrain and post-embryonic development, Wnt signaling, ECM disassembly, elastin and tissue remodeling, and amelogenesis. These terms together suggest coordinated signaling and ECM turnover during morphogenesis and tissue formation, with a few outliers (transcriptional repression and defense response) that are less central to the core theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":6},{"id":"GO:0044130","count":5},{"id":"GO:0016055","count":5},{"id":"GO:0022617","count":4}]},{"hash":"2171370422734899117","title":"Developmental patterning and organ morphogenesis","description":"This cluster centers on embryonic development and tissue patterning across multiple organs (palate, heart endocardial cushion EMT, midbrain, left/right axis, placenta, trophoblasts, endocrine organs, pancreas, cartilage). The GO terms point to broad developmental programs and morphogenetic processes rather than a single molecular function, suggesting a cohesive theme of developmental patterning and organogenesis. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0060021","count":5},{"id":"GO:0003198","count":5},{"id":"GO:0030901","count":5},{"id":"GO:0060972","count":4}]},{"hash":"1462136219514292796","title":"Ubiquitin-Dependent Mechanotransduction and Cell Signaling","description":"This cluster centers on processes tied to ubiquitin-mediated protein turnover and mechanotransduction signaling, including ubiquitination, cellular response to mechanical stimuli, and cell migration, supported by intracellular signaling terms. Peripheral terms like vitamin D response and telomere maintenance are less central, but do not override the main theme. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0016477","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0000083","count":5},{"id":"GO:0035556","count":5}]},{"hash":"932481712259245970","title":"Embryonic development and organogenesis","description":"The Top Terms point to broad developmental processes across embryogenesis, including left-right patterning, mesoderm/placental differentiation, trophoblast and pancreatic lineage development, and tissue morphogenesis (cartilage, roof of the mouth, EMT). Together they indicate a cluster focused on early developmental patterning and organ formation rather than a single tissue function. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003323","count":4}]},{"hash":"1821928005864250724","title":"Embryonic patterning and tissue morphogenesis","description":"Most top GO terms describe early development and organ/tissue formation (left/right patterning, placental/trophoblast differentiation, endocrine and pancreatic development, EMT in endocardial cushion formation, cartilage morphogenesis). A minority relate to innate immunity (innate immune response, defense against virus, TLR signaling), but the dominant signal is embryonic morphogenesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0060806","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0035270","count":6},{"id":"GO:0003323","count":6}]},{"hash":"2159463698145103518","title":"Gametogenesis with meiotic RNA silencing","description":"The terms cluster around spermatid development and male meiotic processes (centrosome localization, meiotic division) and together with RNA-guided gene silencing (miRNA-mediated translation inhibition, mRNA cleavage) and poly(A) tail regulation point to germline development with post-transcriptional control. Some outlier/obsolete terms reduce coherence slightly, so the label is plausible but not definitive.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:0051660","count":3},{"id":"GO:0007286","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0000335","count":2}]},{"hash":"606593680337855969","title":"Ubiquitin-Dependent Antiviral Innate Immunity","description":"The cluster shows enrichment for ubiquitin-dependent protein catabolic processes and protein ubiquitination together with innate immune response and defense against virus, suggesting a module centered on ubiquitin-mediated regulation of antiviral innate defenses.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":9},{"id":"GO:0045087","count":5},{"id":"GO:0051607","count":5},{"id":"GO:0016567","count":5},{"id":"GO:0098907","count":4}]},{"hash":"1208734743243912323","title":"Innate immune signaling and ubiquitin regulation","description":"This cluster is dominated by GO terms for innate immune response and defense against viruses, coupled with ubiquitin-dependent proteolysis and TNF signaling (including autoubiquitination and ERAD). While vitamin D response and T follicular helper cell differentiation are present, the core theme ties to innate antiviral defense and regulation via ubiquitin pathways and TNF signaling, justifying a combined label that highlights immunity and ubiquitin-mediated control.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":11},{"id":"GO:0051607","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0033280","count":10},{"id":"GO:0030433","count":9}]},{"hash":"325153209395702563","title":"Immune Cell Chemotaxis and Inflammatory Signaling","description":"The top GO terms center on chemotaxis of neutrophils, T cells, and monocytes, plus immune response and prostaglandin- and calcium-mediated signaling, with platelet activation. This points to a coordinated inflammatory response involving immune cell recruitment and signaling rather than a single pathway, justifying a label focused on chemotaxis and inflammation.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090023","count":7},{"id":"GO:0045986","count":7},{"id":"GO:0051281","count":7},{"id":"GO:0006955","count":7},{"id":"GO:0010818","count":7}]},{"hash":"1419264878951132912","title":"Neural crest development and axon guidance","description":"This cluster is enriched for GO terms related to neural crest cell migration, axon guidance and fasciculation, CNS development, semaphorin-plexin signaling, and related adhesion processes, suggesting a coordinated neural crest\u2013driven program for nervous system wiring and heart-associated development. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":4},{"id":"GO:0007413","count":4},{"id":"GO:0032836","count":3},{"id":"GO:0007417","count":3},{"id":"GO:0003198","count":3}]},{"hash":"912951443242115241","title":"Neuroadrenergic and dopaminergic signaling","description":"The top GO terms cluster around adrenergic receptor signaling (MAPK-activating and PLC-activating), norepinephrine-epinephrine\u2013driven vasoconstriction, and dopaminergic synaptic transmission, with a brain renin-angiotensin system signal also tying into neural regulation. This points to a neuroendocrine/neurotransmitter signaling module centered on adrenergic and dopaminergic pathways, despite a few peripheral or immune-related terms. ","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":14},{"id":"GO:0001963","count":14},{"id":"GO:1900453","count":14},{"id":"GO:0001994","count":14},{"id":"GO:0071883","count":14}]},{"hash":"99915887097406282","title":"Actin Cytoskeleton Remodeling in Mitosis","description":"These proteins are strongly linked to actin dynamics, including actin filament polymerization and mitotic actomyosin contractile ring assembly, plus mitotic cytokinesis and related cytoskeletal organization. The presence of endocytosis regulation and mitochondrial localization/inheritance terms suggests coordination between cytoskeletal remodeling, membrane trafficking, and organelle inheritance during cell division. Confidence: High","confidence":"","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":14},{"id":"GO:0000001","count":14},{"id":"GO:0043486","count":14},{"id":"GO:0016344","count":14},{"id":"GO:0098974","count":14}]},{"hash":"1914298141862227035","title":"Neuronal synapse development and plasticity","description":"The top GO terms converge on synaptic remodeling: long-term synaptic depression, dendritic spine morphogenesis, and positive regulation of synapse structural plasticity point to changes at excitatory synapses. Behavioral terms such as vocalization and social behavior reflect neural circuits governing communication and social interactions. Regulation of Rho signaling ties to cytoskeletal rearrangements driving spine formation and synapse maturation, while junctional and myelin-associated localizations support structural connectivity and neuron-glia interactions that underpin synaptic function. Overall, the cluster centers on neuronal connectivity and synaptic plasticity.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060292","count":14},{"id":"GO:0060997","count":14},{"id":"GO:0071625","count":14},{"id":"GO:0070830","count":14},{"id":"GO:0035176","count":14}]},{"hash":"1904236667676760029","title":"Transcription Regulation and mRNA Processing","description":"The top GO terms cluster around DNA-templated transcription, its regulation, and mRNA processing (including deadenylation), suggesting the proteins collectively function in gene expression control. Some terms related to reproduction or hematopoietic processes appear but do not define the core theme; the dominant signal is transcriptional regulation and RNA maturation.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0007620","count":2},{"id":"GO:0061484","count":2}]},{"hash":"1258170913956358494","title":"Mitotic spindle assembly and microtubule dynamics","description":"The cluster shows strong enrichment for GO terms related to microtubule dynamics and mitotic spindle functions, including plus- and minus-end directed microtubule sliding, end-directed depolymerization, spindle assembly and elongation, centrosome separation, kinetochore attachment, and maintenance of microtubule polarity. These collectively point to a cohesive role in mitotic spindle organization and microtubule regulation, with a couple of tissue-specific terms (cerebellar structure and epidermal homeostasis) that are likely context-dependent rather than core functions.","confidence":"High","size":15,"edges":32,"triangles":33,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070462","count":15},{"id":"GO:0021685","count":15},{"id":"GO:0031535","count":15},{"id":"GO:0099607","count":15},{"id":"GO:0000022","count":15}]},{"hash":"623435398689642683","title":"Neural crest and brain development","description":"These terms cluster around early embryogenesis with emphasis on neural crest\u2013driven peripheral nervous system development, brain region specification (midbrain, telencephalon), and craniofacial morphogenesis, plus cranial skeleton development. A few outliers related to branching morphogenesis in other organs appear, but the dominant theme is neural crest\u2013associated neural and craniofacial development.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0090009","count":5},{"id":"GO:0030901","count":4},{"id":"GO:0048935","count":4},{"id":"GO:0021978","count":3}]},{"hash":"63426340810595317","title":"Calcineurin-NFAT\u2013driven cardiac hypertrophy and calcium signaling","description":"The top GO terms cluster around calcium ion transport and regulation, the calcineurin-NFAT signaling cascade involved in stress-induced cardiac hypertrophy, oxidative stress, and vascular branching, suggesting a cohesive theme of calcium-dependent signaling driving cardiac hypertrophy and related vessel remodeling. Some cell cycle terms are present but do not overshadow the dominant hypertrophy-calcium\u2013oxidative stress pattern.","confidence":"Medium","size":15,"edges":95,"triangles":346,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000272","count":15},{"id":"GO:0014898","count":15},{"id":"GO:0051531","count":15},{"id":"GO:0042554","count":15},{"id":"GO:0000278","count":15}]},{"hash":"614789989058836782","title":"Rac/Rho-driven actin remodeling in neurons","description":"This cluster centers on actin cytoskeleton dynamics driven by Rac and Rho signaling, including lamellipodium assembly and actin-based movement, which align with neuron projection development and paranode axon localization. Despite a few peripheral terms (ATP export, foregut morphogenesis), the dominant pattern reflects Rac/Rho-regulated actin remodeling in neuronal processes.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904669","count":2},{"id":"GO:0016601","count":2},{"id":"GO:0030048","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0030032","count":2}]},{"hash":"1293841272848154908","title":"Immune and neural signaling pathways","description":"The top GO terms show strong enrichment for immune-related signaling (T cell receptor signaling, LPS response, GM-CSF stimulus) along with receptor tyrosine kinase pathways (ephrin signaling) and neuronal development cues (axon extension, visual perception). This points to a cluster of proteins involved in broad signal transduction and transcriptional regulation that connects immune responses with neural signaling and guidance, including cell migration. ","confidence":"Medium","size":15,"edges":58,"triangles":96,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0050852","count":11},{"id":"GO:0006351","count":10},{"id":"GO:0097011","count":10},{"id":"GO:0071222","count":9},{"id":"GO:0000278","count":7}]},{"hash":"762367227667552855","title":"Spliceosome and Viral-Host Interaction Factors","description":"The cluster shows strong representation of mRNA splicing and spliceosome-related processes, alongside virion-related terms (virion assembly, viral budding, viral release) and host-pathogen interaction terms. This pattern suggests proteins connected to RNA processing that also participate in viral life cycle stages and host responses, indicating a bridge between host RNA machinery and viral interactions.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000387","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2}]},{"hash":"2010747963116168377","title":"Vesicle trafficking and endocytosis","description":"The proteins show strong enrichment for GO terms related to intracellular membrane trafficking, especially ER-Golgi and Golgi-ER transport, endocytosis, endosome transport, and delivery to vacuoles/melanosomes, indicating a core function in vesicle-mediated transport and membrane trafficking. Some terms like mitochondrial inheritance and kinase regulation appear ancillary rather than central.","confidence":"High","size":15,"edges":11,"triangles":1,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006890","count":14},{"id":"GO:0006897","count":14},{"id":"GO:0006623","count":14},{"id":"GO:0035646","count":14},{"id":"GO:0006888","count":14}]},{"hash":"649380767090848096","title":"mRNA Splicing and Post-transcriptional Regulation","description":"This cluster is dominated by GO terms related to mRNA processing, including splicing (GO:0006376), export (GO:0006406), and stabilization (GO:0048255), as well as regulation by ncRNA and miRNA silencing (GO:0035278, GO:0031047). Additional terms point to spliceosome assembly and translation preinitiation complex formation (GO:0034462, GO:0001731), indicating a broader RNA-processing and post-transcriptional regulatory role. The combination suggests a cohesive function in mRNA maturation and gene expression control at the RNA level.","confidence":"High","size":15,"edges":90,"triangles":300,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":12},{"id":"GO:0006406","count":12},{"id":"GO:0048255","count":12},{"id":"GO:0035278","count":12},{"id":"GO:0031047","count":12}]},{"hash":"1539433066851732631","title":"Upregulated signal transduction via PI3K/AKT/MAPK","description":"It is enriched for positive regulation of PI3K/AKT signaling, GTPase activity, and tyrosine phosphorylation (including STAT), as well as MAPK-related activity and nitric oxide biosynthesis, indicating coordinated activation of kinase signaling pathways involved in growth and vascular/immune responses. ","confidence":"High","size":15,"edges":37,"triangles":29,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048661","count":4},{"id":"GO:0051897","count":4},{"id":"GO:0034605","count":4},{"id":"GO:0007275","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1062706076465968033","title":"Unknown","description":"The top GO terms span very diverse biological contexts (gonad development, miRNA silencing, thyroid hormone response, actin regulation, muscle stretch detection, Pol II transcription, motor neuron differentiation/migration, nephric duct elongation, and plant ovule morphogenesis). They do not point to a single coherent functional theme, so a concise, representative label cannot be confidently assigned beyond Unknown.","confidence":"","size":15,"edges":16,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":14},{"id":"GO:2000637","count":14},{"id":"GO:0097067","count":14},{"id":"GO:0030835","count":14},{"id":"GO:0035995","count":14}]},{"hash":"1344353344189397289","title":"Gram-positive fatty acid biosynthesis and lipoteichoic acid synthesis","description":"Top GO terms cluster around fatty acid biosynthesis, long-chain/very long-chain fatty acid metabolism, fatty acid import, and lipoteichoic acid biosynthesis, with ancillary catabolic processes. This paints a cohesive picture of lipid metabolism coupled to cell-envelope component production in Gram-positive bacteria. An occasional bioluminescence term appears but does not alter the primary lipid-enrichment theme.","confidence":"High","size":15,"edges":102,"triangles":419,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":8},{"id":"GO:0090410","count":6},{"id":"GO:0001676","count":6},{"id":"GO:0070395","count":6},{"id":"GO:0008218","count":6}]},{"hash":"1593455124980451504","title":"Cardiac developmental signaling and proteoglycan biosynthesis","description":"The top GO terms center on heart development and developmental signaling (e.g., smoothened pathway), with several entries related to extracellular matrix proteoglycan biosynthesis (heparan and chondroitin sulfate). Although the cluster has no edges, these terms together suggest a theme of signaling processes involved in cardiac development and ECM components. Confidence: Medium","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0043950","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0015015","count":3},{"id":"GO:0030206","count":3}]},{"hash":"2115416855378585216","title":"Developmental morphogenesis and cell migration","description":"Top terms indicate ECM remodeling (collagen fibril organization), tissue-specific morphogenesis (vestibular receptor cell morphogenesis, salivary gland boundary specification, forebrain cell migration), and related processes (slit diaphragm assembly, synapse organization, angiogenesis, and substrate-dependent cell migration/adhesion), pointing to a cohesive theme of developmental tissue morphogenesis guided by ECM\u2013cell interactions and cell migration.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030199","count":11},{"id":"GO:0060116","count":11},{"id":"GO:1904237","count":11},{"id":"GO:0055072","count":11},{"id":"GO:0050808","count":11}]},{"hash":"1757118582723216519","title":"Neuronal Morphogenesis & Cytoskeletal Regulation","description":"The cluster is dominated by GO terms tied to neural development and cytoskeletal dynamics: dendritic spine morphogenesis and nervous system development are prominent (6 each), with supporting signals from regulation of Rho-mediated and actin cytoskeleton processes, plus structural organization like sarcomere and collagen fibril arrangement. Vestibular receptor cell morphogenesis reinforces a sensory-neural theme. Some signaling terms (STAT phosphorylation, IL-27\u2013mediated signaling) suggest broader regulatory networks that intersect these processes. Overall, the set points to neuronal morphogenesis coupled with cytoskeletal remodeling.","confidence":"High","size":15,"edges":86,"triangles":263,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060997","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0042517","count":6},{"id":"GO:0070106","count":6},{"id":"GO:0035023","count":5}]},{"hash":"286509887091862649","title":"Transcription Regulators of Insulin Signaling","description":"The top GO terms include regulation of insulin receptor signaling pathway and transcription-related processes (negative regulation of transcription by RNA polymerase II and DNA-templated transcription), suggesting proteins that modulate gene expression in metabolic signaling contexts.","confidence":"","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046626","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0009409","count":3},{"id":"GO:0016477","count":3}]},{"hash":"1169492667005402573","title":"Actin dynamics and MAPK signaling","description":"This cluster centers on actin cytoskeleton remodeling (lamellipodium/ruffle assembly, actin polymerization, barbed-end capping) and regulation of signaling pathways (GTPase activity, p38 and JNK cascades). Together these terms point to a cohesive theme of cytoskeleton-driven signaling and its role in processes like barrier formation and development.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903753","count":3},{"id":"GO:0090557","count":3},{"id":"GO:0043547","count":3},{"id":"GO:1904888","count":3},{"id":"GO:0046328","count":3}]},{"hash":"1416252795168141432","title":"Cardiac GPCR signaling and catecholamine secretion","description":"This cluster centers on G protein-coupled receptor signaling, including GPCR internalization and acetylcholine receptor signaling, plus related intracellular signal transduction and regulation of catecholamine release. The inclusion of heart-related terms like heart rudiment formation and regulation of heart contraction by chemical signals supports a cardiac context, suggesting a theme of GPCR-driven signaling in heart development and neuroendocrine control. Some terms (e.g., zygote division, mismatch repair, symbiont-NF-kappaB activation) appear peripheral, but they do not overturn the core GPCR/cardiac signaling theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003315","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0003108","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0002031","count":2}]},{"hash":"775887595504241367","title":"Transcriptional control of development and regeneration","description":"The cluster is dominated by transcription by RNA polymerase II, with many GO terms tied to differentiation and tissue regeneration across multiple lineages (bone, blood cells, liver, plasma cells), wound healing, circadian rhythm, and axis/patterning specification, suggesting a cohesive role in regulating developmental and regenerative programs through transcriptional control.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0035470","count":10},{"id":"GO:0045669","count":9},{"id":"GO:2000016","count":9},{"id":"GO:0043353","count":9}]},{"hash":"1463570063037808205","title":"Golgi- and synaptic vesicle trafficking","description":"This cluster is dominated by GO terms for intra-Golgi vesicle transport, ER-to-Golgi transport, Golgi ribbon formation, vesicle fusion with the Golgi, SNARE complex assembly, and exocytic insertion of neurotransmitter receptors at the postsynaptic membrane, plus long-term potentiation and mucus secretion. Together these indicate a shared role in vesicle trafficking and SNARE-mediated membrane fusion, spanning Golgi network processes and synaptic exocytosis. A concise label reflecting SNARE-driven vesicle transport in Golgi and at synapses captures the core function.","confidence":"High","size":15,"edges":52,"triangles":96,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006891","count":9},{"id":"GO:0090161","count":9},{"id":"GO:0006888","count":9},{"id":"GO:0048280","count":9},{"id":"GO:0035493","count":8}]},{"hash":"557869363979373629","title":"Nuclear RNA processing and translation initiation","description":"The top GO terms center on post-transcriptional RNA handling and export (nuclear mRNA export, nuclear mRNA surveillance, tethering of RNA Pol II at the nuclear periphery) together with translation initiation and reinitiation (formation of translation preinitiation complex, translation reinitiation). This suggests a coherent theme of coordinating RNA maturation and export with the initiation of translation, with broader references to cell cycle and differentiation that reflect general developmental and proliferative contexts. Confidence in this label is Medium.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030182","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0000973","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1920687980638897742","title":"Vesicle Trafficking and Organelle Biogenesis","description":"The GO terms point to vesicle-mediated transport and organelle formation/maintenance (ER\u2013Golgi transport, vesicle docking, vacuolar targeting, melanosome assembly, spermatid/acrosome-related processes) as the core theme, with autophagy supporting the degradative trafficking aspect. While development-related terms appear, the common thread is intracellular trafficking and organelle biogenesis rather than a single tissue- or process-specific function.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007286","count":3},{"id":"GO:1903232","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0006914","count":3}]},{"hash":"225015938241303106","title":"Broad-range solute transporters","description":"Top GO terms indicate transmembrane transport for a diverse set of substrates (nitrate, nitrite, arabinose, sialic acid, phosphate, organic acids, xenobiotics, sodium, etc.), with an additional vesicular transport-related term. This pattern supports a cohesive group of membrane transport proteins with broad substrate specificity, including vesicle-associated transport. ","confidence":"Medium","size":15,"edges":23,"triangles":3,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0098700","count":3},{"id":"GO:0015751","count":3},{"id":"GO:0015739","count":3}]},{"hash":"1080758693435525621","title":"SMAD/TGF-\u03b2 developmental signaling","description":"The cluster centers on SMAD-mediated signal transduction with a broad set of developmental GO terms across multiple tissues (endocardial cushion EMT, midbrain, osteoblast and cartilage development, lens fiber differentiation, salivary gland cavitation) and includes miRNA transcription regulation, suggesting a general role in developmental signaling rather than a single tissue-specific function.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060395","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0060038","count":3},{"id":"GO:0060662","count":3}]},{"hash":"1652879304697965567","title":"Mitotic Cell Cycle Regulation","description":"This cluster centers on transitions and control of mitosis\u2014G1/S and G2/M transitions, re-entry into the mitotic cycle, and spindle pole separation\u2014as well as regulation of cyclin-dependent kinase activity and transcription, indicating a cohesive theme of cell-cycle progression and growth signaling. Peripheral terms such as insulin receptor signaling, mammary-gland proliferation, and stomatal opening appear but do not redefine the core mitotic focus.","confidence":"High","size":15,"edges":30,"triangles":22,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0046626","count":7},{"id":"GO:0000082","count":5},{"id":"GO:0033598","count":5},{"id":"GO:0000320","count":5},{"id":"GO:1990069","count":5}]},{"hash":"2138680917401561238","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":15},{"id":"GO:0000278","count":15},{"id":"GO:0010224","count":13},{"id":"GO:1905869","count":13},{"id":"GO:0043547","count":13}]},{"hash":"1926993118209498395","title":"Epigenetic DNA methylation and heterochromatin regulation","description":"This cluster is dominated by GO terms related to DNA methylation and heterochromatin formation (including CG methylation, histone H3-K9 methylation, and methylation-dependent chromatin states), suggesting a core role in epigenetic regulation. A few terms reference Rho signaling and mechanosensation, but these are less represented and do not define the cluster\u2019s main function.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007266","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0010069","count":4},{"id":"GO:0043046","count":4}]},{"hash":"2154846797716441870","title":"Spliceosome Assembly and RNA Processing","description":"Dominant GO terms relate to mRNA splicing via the spliceosome, spliceosomal snRNP and complex assembly, and nuclear RNA processing, suggesting a cohesive spliceosome/RNA processing cluster.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":11},{"id":"GO:1901407","count":7},{"id":"GO:0000245","count":7},{"id":"GO:0030490","count":6},{"id":"GO:0070317","count":6}]},{"hash":"1267954315596268022","title":"Immune Signaling and Ubiquitin-Proteasome Regulation","description":"GO terms show strong representation of immune signaling (T cell receptor signaling, TNF-mediated signaling) alongside ubiquitin-related processes (deubiquitination, proteasomal degradation) and regulatory control of ubiquitin ligase activity, plus Wnt signaling modulation and development. This suggests a cohesive cluster of proteins involved in immune signaling intertwined with ubiquitin-proteasome\u2013mediated regulation of protein turnover and signaling crosstalk.","confidence":"Medium","size":15,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":3},{"id":"GO:0051436","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0090090","count":3},{"id":"GO:0007275","count":2}]},{"hash":"2179815968495059127","title":"Neuronal signaling and mitochondrial import","description":"This cluster is dominated by nervous-system related terms (learning, behavioral fear response, neuron-neuron synaptic transmission, ciliogenesis) suggesting a neuronal function. It also includes terms for mitochondrial protein import and ion transport, indicating a link to mitochondrial processes and cellular ion homeostasis within neurons. The combination points to proteins involved in neuronal signaling with mitochondrial involvement. Confidence: Medium","confidence":"","size":15,"edges":21,"triangles":16,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":5},{"id":"GO:0031101","count":5},{"id":"GO:0030150","count":5},{"id":"GO:1903959","count":5},{"id":"GO:2000378","count":5}]},{"hash":"1820876407058711379","title":"Chromatin Regulation and Development","description":"The top GO terms cluster around nuclear processes that regulate chromatin state and transcription (histone mRNA catabolic process, apoptotic chromosome condensation, protein sumoylation, regulatory ncRNA-mediated gene silencing, DNA damage response to X-ray), complemented by developmental and differentiation terms (forebrain development, ductus arteriosus closure, negative regulation of muscle differentiation). This suggests a broad theme of chromatin- and transcription-level control engaged in developmental contexts, rather than a single, cohesive pathway.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071044","count":4},{"id":"GO:0030900","count":3},{"id":"GO:0097070","count":3},{"id":"GO:0016925","count":3},{"id":"GO:2001015","count":3}]},{"hash":"1019670848588211217","title":"Immune adhesion, activation, and phagocytosis","description":"The cluster is dominated by immune system functions: cell adhesion terms that facilitate immune cell interactions, B cell activation and BCR signaling, T cell proliferation, innate immune response, phagocytosis, and complement activation. The ossification term seems incidental. So a label emphasizing immune activation and phagocytic processes best represents the cluster.","confidence":"High","size":15,"edges":66,"triangles":90,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0043931","count":7},{"id":"GO:0050871","count":7},{"id":"GO:0045087","count":7}]},{"hash":"1428477705766628987","title":"Long-chain fatty acid biosynthesis and metabolism","description":"The top GO terms are dominated by fatty acid biosynthetic and metabolic processes, including long-chain and very long-chain fatty acid metabolism, fatty acid import, and lipoteichoic acid biosynthesis (a lipid component of the bacterial cell envelope). This points to a protein cluster focused on lipid biosynthesis and fatty acid utilization, with some ancillary catabolic pathways (malonate, phenylacetate) present but secondary. Overall, the cluster appears to represent long-chain fatty acid metabolism and related lipid biosynthesis in bacteria.","confidence":"High","size":15,"edges":75,"triangles":181,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902987","count":9},{"id":"GO:0090410","count":7},{"id":"GO:0006633","count":7},{"id":"GO:0001676","count":7},{"id":"GO:0070395","count":7}]},{"hash":"1863365373507257121","title":"Eye development and morphogenesis","description":"This cluster is dominated by eye-related developmental terms: embryonic eye morphogenesis, camera-type eye development, left/right pattern formation, and positive regulation of lens epithelial cell proliferation, suggesting a cohesive role in ocular formation and patterning. Some transcriptional regulation and broader morphogenesis terms appear but are likely secondary to the core eye-development theme.","confidence":"High","size":15,"edges":68,"triangles":113,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0043010","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0060972","count":4}]},{"hash":"1958468557427879007","title":"Inflammatory redox signaling and gasotransmitter production","description":"This cluster centers on inflammatory and redox-related processes, including response to toxic substances, nitrosative stress, and production of signaling molecules like IL-8, nitric oxide, hydrogen sulfide, and prostaglandins. The presence of both inflammatory mediators and redox-related biosynthetic processes (NO, H2S, ROS-related terms) suggests a cohesive theme of redox-regulated inflammation with vascular remodeling implications.","confidence":"High","size":15,"edges":53,"triangles":86,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":13},{"id":"GO:0055114","count":12},{"id":"GO:0071500","count":12},{"id":"GO:0072606","count":12},{"id":"GO:0045429","count":12}]},{"hash":"451446823565148181","title":"Unknown","description":"The top GO terms span plant defense signaling (salicylic acid\u2013mediated response) and a mix of unrelated metabolic and signaling processes (oxaloacetate, sphinganine, porphyrin biosynthesis, fatty acid transport, Notch signaling, kynurenine, biotin biosynthesis), with no clear, single theme tying them together. Therefore, a specific, intuitive label cannot be reliably assigned.","confidence":"","size":15,"edges":27,"triangles":17,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009862","count":4},{"id":"GO:0006107","count":4},{"id":"GO:0046511","count":4},{"id":"GO:0006782","count":4},{"id":"GO:0019550","count":4}]},{"hash":"1022543656874192325","title":"Redox Detoxification and Osmotic Stress Response","description":"The cluster's GO terms highlight oxidative stress detoxification (cellular oxidant detoxification) and multiple osmotic stress responses (response to mannitol, water deprivation, sucrose), with bacillithiol biosynthesis supporting redox protection in bacteria. A few divergent or obsolete annotations (e.g., starch biosynthetic process) exist, but the dominant theme is redox homeostasis tied to osmotic stress adaptation.","confidence":"Medium","size":15,"edges":14,"triangles":0,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0019252","count":1},{"id":"GO:0010555","count":1},{"id":"GO:0009405","count":1}]},{"hash":"1638088265226677194","title":"Dopaminergic Signaling and Cocaine Response","description":"This cluster centers on brain-related signaling and sensory processing, highlighted by dopaminergic synaptic transmission, visual perception and learning, ERK cascade modulation, and behavioral responses to cocaine. While a couple of terms like heart development and macrophage chemotaxis appear, the dominant pattern is neuronal signaling and cocaine-associated behavioral responses.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":12},{"id":"GO:0070374","count":12},{"id":"GO:0001963","count":12},{"id":"GO:0048148","count":12},{"id":"GO:0071380","count":12}]},{"hash":"680092191765531761","title":"Steroid and Prostaglandin Lipid Metabolism","description":"The cluster\u2019s top GO terms point to biosynthesis and metabolism of lipid signaling molecules, notably prostaglandins and several steroid hormones (androgen, progesterone, aldosterone), with the omega-hydroxylase P450 pathway supporting lipid modification. This suggests a cohesive theme around lipid/hormone production and regulation, potentially linked to vascular and stress-related biology, so a label emphasizing steroid and prostaglandin lipid metabolism fits well.","confidence":"High","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":13},{"id":"GO:0097267","count":12},{"id":"GO:0033076","count":12},{"id":"GO:0008585","count":12},{"id":"GO:0035902","count":12}]},{"hash":"2101001865544928242","title":"Unknown","description":"The top GO terms span several distinct areas: TORC2 signaling, negative regulation of Ras signaling, GPCR-related signaling, transcription initiation and repression by RNA Pol II, insulin processing, and regulation of fibrinolysis/plasminogen activation, plus sensory perception of sound. There is no clear, cohesive biological theme tying all proteins together, suggesting a mix of unrelated regulatory roles rather than a single functional cluster. ","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038203","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0051262","count":2},{"id":"GO:0007205","count":2}]},{"hash":"2039788792684924278","title":"Cardiovascular inflammation and neural signaling","description":"This cluster is dominated by terms related to cardiovascular biology (heart development, blood coagulation, vasoconstriction) and inflammatory responses (inflammatory response, LPS response), with additional signals relating to dopaminergic synaptic transmission and brain renin-angiotensin system. The combination suggests a theme of cardiovascular inflammatory processes alongside neural signaling components.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":10},{"id":"GO:0045986","count":10},{"id":"GO:0045907","count":10},{"id":"GO:0007596","count":10},{"id":"GO:0019233","count":10}]},{"hash":"210655821839092420","title":"Pain and Temperature Sensory Signaling with Inflammation","description":"This cluster centers on pain perception and temperature-related responses (sensory pain, thermogenesis, cellular response to temperature, prepulse inhibition, drug response) and also touches vascular regulation and immune/inflammatory signaling (vasoconstriction, coagulation, LPS response). Together, these terms suggest a module of proteins involved in nociception/thermosensation tied to vascular and inflammatory responses. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0045986","count":7},{"id":"GO:0060134","count":7}]},{"hash":"626722377535904186","title":"Adrenergic and Dopaminergic Neurotransmission","description":"This cluster is dominated by GO terms related to dopaminergic synaptic transmission, morphine response, and adrenergic receptor signaling pathways, indicating a core theme of neuronal signaling. Additional terms point to brain renin-angiotensin system, vasoconstriction and blood pressure regulation, and MAPK-activating PLC signaling, suggesting a broader neurovascular signaling network modulated by adrenergic/dopaminergic activities. A minority of terms touch immune cell processes, which may reflect broader signaling cross-talk. Overall, the label reflects the central theme of neurotransmission and adrenergic signaling.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043278","count":12},{"id":"GO:0002035","count":11},{"id":"GO:0001963","count":11},{"id":"GO:1900453","count":11},{"id":"GO:0001994","count":11}]},{"hash":"910331619218151391","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":2},{"id":"GO:0000381","count":2},{"id":"GO:0007175","count":1},{"id":"GO:0000494","count":1},{"id":"GO:1904876","count":1}]},{"hash":"2019339768043465471","title":"Development and cell\u2013cell adhesion signaling","description":"This cluster is dominated by terms for developmental processes (angiogenesis, heart development, ossification, multicellular organism development) and cell\u2013cell adhesion with actin cytoskeleton regulation, suggesting a cohesive role in tissue development and intercellular interactions. Some immune signaling and potassium channel clustering terms are present but do not override the core developmental/adhesion theme.","confidence":"High","size":15,"edges":11,"triangles":0,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":11},{"id":"GO:0043931","count":11},{"id":"GO:0032516","count":11},{"id":"GO:0007507","count":10},{"id":"GO:0007275","count":10}]},{"hash":"1698186959947405366","title":"Neuronal ion transport and synaptic signaling","description":"The cluster is dominated by GO terms for potassium and sodium ion transmembrane transport and various synaptic signaling processes (excitatory postsynaptic potential, GABA signaling, positive regulation of synaptic transmission), plus behavioral associations like locomotory behavior and conditioned taste aversion. These together point to a core theme of neuronal excitability and synaptic communication, likely involving ion channels/transporters that regulate synaptic transmission. A couple of outlier terms about cell wall catabolic processes are present but do not redefine the main theme.","confidence":"High","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":15},{"id":"GO:0060079","count":15},{"id":"GO:0035725","count":15},{"id":"GO:0001661","count":14},{"id":"GO:0007626","count":14}]},{"hash":"1319357723731546963","title":"Embryonic Development and Axis Patterning","description":"The top GO terms cluster around developmental processes across germ layers and axis specification (endoderm, mesoderm, somite patterning, maternal effects) and tissue/organ differentiation (lens, palate, pancreas), suggesting a cohesive theme of embryogenesis and patterning.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0003323","count":4},{"id":"GO:0007492","count":3},{"id":"GO:2000249","count":3},{"id":"GO:0032092","count":3}]},{"hash":"1884807545001572060","title":"Immune cell signaling and metabolic regulation","description":"These proteins show GO terms centered on immune-related processes (positive regulation of mononuclear cell migration; regulation of activated T cell proliferation), alongside general signal transduction and metabolic responses (cellular response to glucose; regulation of lipid catabolic process). While a couple terms are less connected (neuron projection development, Lewis a epitope biosynthesis), the dominant theme is signaling pathways that regulate immune cell behavior in the context of metabolic cues, suggesting a cluster of immune signaling linked to metabolism.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0010977","count":2},{"id":"GO:0071407","count":2},{"id":"GO:0010493","count":2}]},{"hash":"879188387663769672","title":"Unknown","description":"The terms span neuromuscular functions (cardiac contraction, GABAergic synaptic transmission, hearing) along with signaling and developmental/metabolic processes, but there is no single coherent biological theme tying all 15 proteins together; the mix of muscle, neural, signaling, and developmental terms makes a precise, representative label unreliable.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060048","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0014065","count":3}]},{"hash":"1615033916599057253","title":"Temperature and pain sensing with immune chemotaxis","description":"This cluster is driven by temperature-related and nociception terms (diet-induced thermogenesis, cellular response to temperature stimulus, sensory perception of pain) and includes immune cell recruitment signals (neutrophil/monocyte chemotaxis) alongside neural processing terms (prepulse inhibition, response to amphetamine) and inflammatory regulation. The common theme appears to be the integration of thermal/pain sensing with neuroimmune signaling and immune cell trafficking.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0019233","count":5},{"id":"GO:0090023","count":4},{"id":"GO:0060134","count":4}]},{"hash":"1977482957183796178","title":"Developmental regulation of muscle, heart, and eye morphogenesis","description":"The top GO terms point to coordinated developmental processes across muscle differentiation, cardiac/vascular morphogenesis, and eye development (e.g., muscle differentiation regulation; ductus arteriosus closure; optic fissure closure; enteric nervous system development), all reflecting tissue morphogenesis and lineage differentiation in vertebrates. This suggests a theme of developmental regulation across multiple tissues rather than a single pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043388","count":4},{"id":"GO:2001015","count":4},{"id":"GO:0061386","count":3},{"id":"GO:0097070","count":3},{"id":"GO:0010832","count":3}]},{"hash":"167082591105433537","title":"Cardiovascular morphogenesis signaling","description":"The dominant terms point to morphogenesis of heart outflow tract and blood vessels, multicellular development, and signaling pathways (Wnt, calcium-modulating, phosphorylation regulation) that govern cell proliferation and differentiation. Although there is also insulin secretion and glucose response signals, the core common thread is developmental signaling controlling cardiovascular structure formation, with kinase activity modulation being a recurring mechanism.","confidence":"Medium","size":15,"edges":21,"triangles":6,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048143","count":5},{"id":"GO:0001569","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0010800","count":4},{"id":"GO:0003151","count":4}]},{"hash":"1894570868723596253","title":"Lymphoid development and cytokine signaling","description":"This cluster centers on lymphoid development and cytokine signaling, with terms for B cell affinity maturation, IL-4 production, NK T cell differentiation, and hematopoiesis, plus PI3K/AKT signaling and cellular responses to IL-7. A few MAPKK terms are obsolete, but the dominant theme is adaptive immune cell development and cytokine-driven signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002344","count":2},{"id":"GO:0032633","count":2},{"id":"GO:0001865","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0098761","count":2}]},{"hash":"2206312082559229630","title":"Drosophila imaginal disc development and cytoskeleton dynamics","description":"This set includes GO terms tied to imaginal disc development and growth (eye-antennal disc development; positive regulation of imaginal disc growth) along with cytoskeletal and cellular organization processes (formin-nucleated actin cable assembly; actin cytoskeleton reorganization; nucleolus organization; ER polarization). There are also meiosis-related terms (polar body extrusion after meiosis; homologous chromosome movement during meiosis I), suggesting a broader context of developmental patterning and cytoskeletal control in Drosophila. Overall, the common theme is developmental regulation in the fly with a emphasis on cytoskeleton dynamics and cellular organization, spanning imaginal disc biology and meiosis-related processes.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007000","count":1},{"id":"GO:0035214","count":1},{"id":"GO:0045572","count":1},{"id":"GO:0061164","count":1},{"id":"GO:0040038","count":1}]},{"hash":"321864490920326540","title":"Brain energy metabolism and development","description":"This cluster is driven by brain-related GO terms (brain development, substantia nigra development) and energy-buffering pathways (phosphocreatine biosynthetic process, creatine metabolic process), suggesting a focus on neuronal development paired with rapid energy supply via creatine in the brain. Some endocytosis and stress/xenobiotic terms are present but don\u2019t define the main function as strongly as the brain development and creatine metabolism signals.","confidence":"High","size":14,"edges":15,"triangles":7,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0097421","count":2},{"id":"GO:0070542","count":2},{"id":"GO:0006898","count":2},{"id":"GO:0016311","count":2}]},{"hash":"1155922249921850550","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":81,"triangles":264,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":14},{"id":"GO:0048701","count":14},{"id":"GO:0072715","count":10},{"id":"GO:2000616","count":10},{"id":"GO:0018144","count":10}]},{"hash":"1125191397729528529","title":"Plant transcription and genome maintenance","description":"These GO terms cluster around transcription-related processes (DNA-templated transcription, snRNA transcription, mRNA splicing) and genome maintenance activities (telomere loop formation, replication-born double-strand break repair via sister chromatid exchange), with supporting roles for protein ubiquitination and plant-specific signaling (response to jasmonic acid, regulation of secondary cell wall biogenesis). This pattern suggests a group of plant proteins involved in transcription/RNA processing that also participate in maintaining genome stability, potentially modulated by hormone signaling.","confidence":"Medium","size":14,"edges":10,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000209","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0009301","count":2},{"id":"GO:1901347","count":2}]},{"hash":"129623769398201325","title":"Central carbon metabolism and biosynthesis","description":"This cluster centers on core energy metabolism and biosynthetic pathways, as indicated by GO terms for glycolysis, the TCA cycle, 2-oxoglutarate metabolism, and various biosynthetic processes (biotin, beta-alanine, antibiotic, porphyrin). The cerebellar cortex development term is likely an outlier/misannotation, so the dominant theme is metabolism and biosynthesis. ","confidence":"High","size":14,"edges":57,"triangles":112,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":7},{"id":"GO:0006096","count":5},{"id":"GO:0006782","count":4},{"id":"GO:0019878","count":4},{"id":"GO:0055114","count":4}]},{"hash":"2079195919319389640","title":"Post-transcriptional mRNA decay and ERK signaling","description":"The top GO terms point to mRNA turnover (deadenylation-dependent/independent decay) and altered cytoplasmic translation, together with ERK cascade and responses to epidermal growth factor, suggesting a cohesive theme of post-transcriptional regulation linked to growth-factor signaling, even though a few terms relate to development or immune processes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:1900153","count":3},{"id":"GO:0042129","count":3},{"id":"GO:0098789","count":3},{"id":"GO:0002635","count":3},{"id":"GO:0070371","count":3}]},{"hash":"919009721791096940","title":"mRNA processing and translation regulation","description":"This cluster is enriched for splicing, export, stabilization, poly(A) tail regulation, miRNA/ncRNA\u2013mediated silencing, and translation preinitiation complex formation, indicating proteins involved in post-transcriptional RNA maturation and control of translation.","confidence":"High","size":14,"edges":37,"triangles":20,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":10},{"id":"GO:0045292","count":10},{"id":"GO:0006376","count":8},{"id":"GO:0006406","count":8},{"id":"GO:0048255","count":8}]},{"hash":"114937691965769845","title":"Neuronal calcium signaling and angiogenesis","description":"This cluster centers on calcium handling and signaling, with links to endothelial cell migration and angiogenesis as well as neural signaling and memory, indicating a shared Ca2+-dependent signaling theme across neural and vascular contexts.","confidence":"High","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0010595","count":4},{"id":"GO:0001525","count":3},{"id":"GO:0070588","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0060079","count":3}]},{"hash":"938176675575651466","title":"Amino acid biosynthesis and transcription regulation","description":"The cluster\u2019s top GO terms are dominated by amino acid biosynthesis and related metabolic processes (D-serine, L-threonine, L-tryptophan biosynthesis; hydrogen sulfide and homocysteine metabolism; coenzyme M biosynthesis) alongside regulation of DNA-templated transcription, suggesting a link between amino acid metabolism and transcriptional control.","confidence":"Medium","size":14,"edges":28,"triangles":15,"max_degree":7,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0009310","count":3},{"id":"GO:0070179","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0000162","count":3}]},{"hash":"1047563226089021811","title":"Cytokine-driven immune activation and lymphocyte regulation","description":"Proteins in this cluster are enriched for immune-related processes: cytokine production, positive regulation of B cell activation, IL-2 production, NK cell regulation and tolerance, and negative regulation of T cell activation, alongside innate immune sensing (peptidoglycan detection). Angiogenesis also appears, consistent with inflammation-associated vascular remodeling. Together, these terms suggest a cohesive theme of immune signaling and lymphocyte regulation, with some vascular/intermediate processes.","confidence":"High","size":14,"edges":16,"triangles":5,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0002859","count":4},{"id":"GO:0050871","count":4},{"id":"GO:1900042","count":4},{"id":"GO:0032499","count":4}]},{"hash":"180388522681937232","title":"Nuclear import and chromosome dynamics","description":"Top GO terms emphasize NLS-bearing protein import into the nucleus, ribosomal protein import, and nuclear pore complex assembly, alongside mitotic chromosome condensation and general cell division. This pattern points to a cohesive group of proteins functioning in nuclear transport and chromosome handling during cell division, justifying the label.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006607","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0006610","count":5},{"id":"GO:0060188","count":5},{"id":"GO:0000060","count":5}]},{"hash":"160015604515417038","title":"Unknown","description":"The terms span mitochondrial electron transport, calcium signaling, neural processes (pain perception, locomotion, prepulse inhibition, synaptic regulation) and bacterial cell wall catabolism/defense, showing no single, coherent function across all proteins.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":6},{"id":"GO:0051482","count":6},{"id":"GO:0051930","count":6},{"id":"GO:0007626","count":6},{"id":"GO:0016998","count":6}]},{"hash":"1004769664347809244","title":"Vascular and skeletal morphogenesis","description":"The top GO terms cluster around regulation and development of blood vessels and bones (angiogenesis, endothelial proliferation, coronary artery morphogenesis, ossification, limb development), with additional signals of general morphogenesis such as cell-substrate adhesion and axon guidance. This suggests a cohesive developmental program governing vascular and skeletal patterning, hence the chosen label. ","confidence":"High","size":14,"edges":45,"triangles":57,"max_degree":12,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0016525","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0001937","count":7},{"id":"GO:0060173","count":7},{"id":"GO:0050731","count":7}]},{"hash":"1811056141764217712","title":"Unknown","description":"The set includes diverse GO terms ranging from telomere maintenance, vascular and developmental processes, immune signaling, pain detection, cell growth, locomotor rhythms, and muscle stretch responses, with no single unifying function tying the proteins together. This suggests there is no coherent cluster theme to name beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":2},{"id":"GO:0097497","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0045083","count":2},{"id":"GO:0050968","count":2}]},{"hash":"1917153869178853041","title":"RNA processing and ribosome biogenesis","description":"This cluster centers on RNA-level processing and ribosome assembly: multiple terms point to mRNA splicing via spliceosome, regulation of splicing, and maturation of rRNA components (SSU/LSU/5.8S) with ribosomal large subunit biogenesis and initiation complex formation. The presence of regulatory ncRNA-mediated silencing and translation initiation suggests a broader RNA-processing/translation module. Cold response and chromatin remodeling appear ancillary but do not override the core RNA/ribosome themes.","confidence":"High","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0000398","count":6},{"id":"GO:0000463","count":6},{"id":"GO:0000462","count":6}]},{"hash":"2090113988877294068","title":"Nuclear ribosome biogenesis and mRNA processing","description":"These proteins are mainly tied to nuclear processes that build ribosomes and manage RNA metabolism (ribosome biogenesis, translation, mRNA export, and spliceosome-related regulation), with links to cell division (kinetochore localization, nuclear import). A few terms are peripheral, but the core theme is coherent: nuclear RNA processing and ribosome production coordinated with the cell cycle.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0006412","count":2}]},{"hash":"1323577128563600427","title":"Developmental differentiation and morphogenesis","description":"The cluster centers on developmental processes across multiple tissues: neurogenesis, myoblast differentiation, vestibular and reproductive tissue morphogenesis, and collagen-mediated extracellular matrix remodeling. Associated signaling pathways (PI3K-AKT, NF-kappaB) and processes like apoptosis and cell proliferation further support a theme of growth, survival, and coordinated differentiation during development. This combination suggests a cohesive label focusing on developmental differentiation and tissue morphogenesis rather than a single tissue-specific function.","confidence":"Medium","size":14,"edges":77,"triangles":234,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0060068","count":8},{"id":"GO:0006915","count":8},{"id":"GO:0022008","count":8},{"id":"GO:0045663","count":7},{"id":"GO:0043491","count":7}]},{"hash":"385804269125760404","title":"Neuronal Ion Transport and Synaptic Signaling","description":"This cluster is dominated by terms for sodium and potassium ion transport across membranes, excitatory postsynaptic potentials, and regulation of glutamatergic and GABAergic signaling, pointing to neuronal communication and synaptic plasticity. Behavioral terms like locomotory behavior and conditioned taste aversion reinforce a neural function theme, while bacterial cell wall catabolic terms appear as outliers. Overall, it reflects neuronal signaling and ion channel\u2013driven communication.","confidence":"High","size":14,"edges":51,"triangles":74,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":8},{"id":"GO:0060079","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0007626","count":7},{"id":"GO:0001661","count":6}]},{"hash":"503377281354523500","title":"Developmental Signaling and Organogenesis","description":"This cluster centers on developmental processes across tissues (angiogenesis, heart development, boundary specification) and neural wiring (synapse organization, dendrite self-avoidance, axon localization), with key signaling pathways (BMP, Hedgehog/Smoothened, STAT). The common theme is proteins coordinating signaling to drive organogenesis and neural development.","confidence":"Medium","size":14,"edges":89,"triangles":341,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0042517","count":8},{"id":"GO:0050808","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0007432","count":7},{"id":"GO:0007507","count":7}]},{"hash":"1594336882769178797","title":"T Cell Signaling and Cytokine Response","description":"This cluster centers on immune signaling: T cell receptor signaling, STAT tyrosine phosphorylation, IL-27 signaling, and Th2 cytokine production, all pointing to T cell activation and cytokine-mediated responses. While terms like roundabout signaling and neural development-related processes are present, the dominant pattern is adaptive immune signaling pathways. ","confidence":"Medium","size":14,"edges":16,"triangles":4,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":9},{"id":"GO:0042517","count":8},{"id":"GO:0035745","count":8},{"id":"GO:0070106","count":8},{"id":"GO:0007169","count":8}]},{"hash":"101257024361366903","title":"Muscle differentiation and transcriptional regulation","description":"The cluster is dominated by GO terms tied to transcription (DNA-templated transcription, RNA polymerase II transcription) and skeletal muscle cell differentiation (myoblast fate determination, positive regulation of skeletal muscle differentiation, skeletal muscle differentiation). This suggests a cohesive module where transcriptional control drives muscle development, with some peripheral terms related to other lineage regulations (osteoblast and androgen receptor signaling) and a few unrelated processes (endocrine pancreas development, humoral immune response) that are likely secondary associations. ","confidence":"High","size":14,"edges":84,"triangles":290,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0045668","count":9},{"id":"GO:0060766","count":9},{"id":"GO:0031018","count":8},{"id":"GO:0035914","count":8}]},{"hash":"1977451841660994046","title":"Translation machinery and tRNA charging","description":"This cluster is dominated by GO terms for translation, ribosome-related assembly/disassembly, and multiple aminoacyl-tRNA synthetase activities, pointing to a core protein synthesis/ribosome function cluster. The presence of translation initiation and preinitiation complex formation terms reinforces this; a few outlier terms like blood vessel morphogenesis do not detract from the central theme. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0032790","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0006431","count":2}]},{"hash":"223449008268518785","title":"Steroid and Prostaglandin Biosynthesis","description":"Based on GO terms such as prostaglandin biosynthetic process and multiple steroid hormone metabolic processes (androgen, progesterone, aldosterone) along with the omega-hydroxylase P450 pathway, this cluster likely groups enzymes involved in lipid mediator and steroid metabolism via cytochrome P450 activity; endothelial cell\u2013cell adhesion and female gonad development terms reflect contextual roles but do not override the core lipid biosynthesis theme.","confidence":"Medium","size":14,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":8},{"id":"GO:0097267","count":8},{"id":"GO:0033076","count":8},{"id":"GO:0008585","count":8},{"id":"GO:0035902","count":8}]},{"hash":"1338158442981778609","title":"Developmental transcription regulation and chromatin remodeling","description":"The cluster is enriched for GO terms centered on DNA-templated transcription and chromatin remodeling (e.g., transcription, regulation of transcription preinitiation complex assembly) and includes several development-related differentiation terms across tissues, suggesting proteins involved in regulating gene expression during development and associated chromatin state changes.","confidence":"High","size":14,"edges":45,"triangles":56,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0017055","count":6},{"id":"GO:0060534","count":6},{"id":"GO:2000020","count":6},{"id":"GO:0070384","count":6}]},{"hash":"423680747681808957","title":"TGF-\u03b2/SMAD signaling in mesodermal and skeletal development","description":"Primarily driven by TGF-\u03b2 receptor signaling and SMAD complex assembly, with links to mesoderm formation and embryonic cranial skeleton morphogenesis, indicating a developmental program for mesodermal and skeletal tissues. Transcriptional regulation is suggested by DNA-templated transcription terms, and muscle-related terms reflect downstream differentiation in mesoderm-derived tissues. A few terms (antibiotic and polyamine biosynthesis) are peripheral but do not override the core developmental theme.","confidence":"High","size":14,"edges":61,"triangles":131,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006939","count":6},{"id":"GO:0048680","count":6},{"id":"GO:0006351","count":5},{"id":"GO:0010614","count":4},{"id":"GO:0001707","count":4}]},{"hash":"1575712067126475896","title":"Embryonic Organogenesis","description":"The cluster shows GO terms centered on embryonic development and organ formation, including heart and pulmonary myocardium development, organ induction, cranial skeleton morphogenesis, otolith morphogenesis, neuron migration, and myelination, alongside broader multicellular organism development and a mechanical stimulus response. This pattern points to a cohesive theme of embryonic organogenesis across multiple tissues in vertebrates.","confidence":"High","size":14,"edges":15,"triangles":2,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0048701","count":5},{"id":"GO:0001759","count":5},{"id":"GO:0003350","count":5}]},{"hash":"2260704127491245715","title":"Immune Cell Signaling and Adhesion Regulation","description":"The cluster centers on immune modulation and intercellular interactions, with GO terms pointing to regulation of NK and T cell cytotoxicity, macrophage activation, and mast cell degranulation, alongside synapse assembly and cell-cell adhesion, and STAT-related signaling. This combination indicates a cohesive theme of how immune cells communicate and regulate each other\u2019s activity through adhesion and signaling pathways.","confidence":"Medium","size":14,"edges":3,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0002859","count":12},{"id":"GO:0043318","count":12},{"id":"GO:0051963","count":11},{"id":"GO:0086072","count":11},{"id":"GO:0007157","count":11}]},{"hash":"2104103755768481489","title":"Lipid Mediator and Hormone Metabolism","description":"The top GO terms cluster around lipid-derived signals and hormone metabolism: prostaglandin biosynthesis (a lipid mediator), omega-hydroxylase P450 pathway (lipid metabolism), and androgen/female gonad\u2013related processes. These point to lipid mediator and hormone biosynthesis as a common theme. Other terms like protein autophosphorylation, endothelial adhesion, and stress responses are more general and don\u2019t strongly tighten the cluster\u2019s function, so the linkage to lipid/hormone processes is present but not tightly cohesive.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046777","count":3},{"id":"GO:0018105","count":3},{"id":"GO:0001516","count":3},{"id":"GO:0097267","count":3},{"id":"GO:0033076","count":3}]},{"hash":"112126257689010485","title":"Neural development and synapse organization","description":"The dominant GO terms cluster around neural development and synapse formation (trigeminal nerve organization, paranodal junction assembly, neural crest\u2013driven sympathetic development) with sensory perception and synaptic activity; a few broader terms like angiogenesis and STAT signaling are present but secondary, making neural development/synapse organization the best overall thematic label.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050910","count":7},{"id":"GO:0002859","count":6},{"id":"GO:0050808","count":6},{"id":"GO:0001798","count":6},{"id":"GO:0001525","count":6}]},{"hash":"1044732267742529788","title":"GABAergic neuronal signaling and microglial regulation","description":"This cluster shows neuronal signaling features (GABAergic synaptic transmission, auditory perception) alongside CNS immune aspects (GM-CSF\u2013driven responses, regulation of microglial migration, and related signaling pathways), suggesting a brain function theme with inhibitory synaptic activity and microglial regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0097011","count":8},{"id":"GO:0090630","count":8},{"id":"GO:0010925","count":7},{"id":"GO:1904140","count":7},{"id":"GO:1904261","count":7}]},{"hash":"2161161143302825197","title":"Post-transcriptional mRNA processing and regulation","description":"These proteins share strong links to RNA processing and control after transcription: spliceosome components and splicing regulation, mRNA export and poly(A) tail regulation, mRNA stabilization, and RNA silencing pathways (miRNA and regulatory ncRNA), plus aspects of translation initiation. This suggests a cohesive role in coordinating splicing, export, stability, and translation of mRNAs.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0048025","count":8},{"id":"GO:0045292","count":7},{"id":"GO:0006376","count":6},{"id":"GO:0006406","count":6}]},{"hash":"1108620945430721278","title":"RNA processing and post-transcriptional gene regulation","description":"This cluster is dominated by GO terms for mRNA maturation and regulation: export from the nucleus, splice-site recognition, translation preinitiation complex formation, mRNA stabilization, poly(A) tail regulation, and miRNA/ncRNA-mediated gene silencing. These collectively point to a group of proteins involved in post-transcriptional control of gene expression, with a couple of incidental terms that are less clearly related.","confidence":"High","size":14,"edges":23,"triangles":0,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":4},{"id":"GO:0009405","count":3},{"id":"GO:1900116","count":3},{"id":"GO:0044179","count":3},{"id":"GO:0006376","count":3}]},{"hash":"873564288930322236","title":"Ubiquitin-mediated NF-\u03baB signaling and cell cycle regulation","description":"These proteins show strong signals for NF-\u03baB pathway regulation (positive regulation of NF-\u03baB activity and canonical NF-\u03baB signaling) and ubiquitin-related processes (K63-linked ubiquitination, autoubiquitination, histone ubiquitination) alongside chromatin organization and mitotic cell cycle entries. This suggests a cohesive module where ubiquitin signaling modulates NF-\u03baB-driven transcription in the context of chromatin remodeling and cell division. ","confidence":"Medium","size":14,"edges":43,"triangles":76,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051092","count":9},{"id":"GO:0051965","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0043123","count":7},{"id":"GO:0070534","count":7}]},{"hash":"1444201416029005044","title":"Synaptic transmission and ion transport","description":"Most top GO terms describe neuronal signaling and membrane excitability: transmission of nerve impulse, sodium/potassium ion transmembrane transport, membrane depolarization, and excitatory postsynaptic potential, which collectively indicate a cluster centered on synaptic transmission and neural excitability. Some terms like cell adhesion, amelogenesis, and complement activation are present but less dominant, likely reflecting shared membrane proteins or multi-function components.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":5},{"id":"GO:0071805","count":4},{"id":"GO:0060079","count":4},{"id":"GO:2001046","count":4},{"id":"GO:0035725","count":4}]},{"hash":"474781419107089097","title":"Retinoid and carbohydrate metabolism cluster","description":"The proteins show strong annotations for retinol metabolism and fructose biosynthesis, with supportive signals from related metabolic pathways (lipid and PPP-related processes). Immune/stress responses appear but are secondary to core metabolism terms, suggesting the cluster mainly reflects metabolic activity with ancillary stimulation signals.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":13},{"id":"GO:0046370","count":11},{"id":"GO:0006069","count":10},{"id":"GO:0006068","count":10},{"id":"GO:0097327","count":8}]},{"hash":"802262530293308287","title":"Innate immune and inflammatory signaling","description":"The dominant GO terms are innate immune response, inflammatory response, and IL-1\u03b2 production, indicating a primary link to immune/inflammatory signaling; other terms like development and DNA-related processes appear as secondary associations.","confidence":"Medium","size":14,"edges":19,"triangles":7,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009245","count":3},{"id":"GO:0035753","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0048741","count":3},{"id":"GO:0007498","count":3}]},{"hash":"484786519175375723","title":"Embryonic development and organ morphogenesis","description":"This cluster\u2019s top GO terms point to development and morphogenesis across multiple tissues and organs during embryogenesis (palate, left/right patterning, mesoderm, placenta, heart cushion, hair follicles, pancreas, endocrine system). The inclusion of an mRNA splicing term is a general cellular process and does not override the overarching developmental theme. Overall, the proteins appear related to embryonic tissue formation and organogenesis, justifying this label.","confidence":"High","size":14,"edges":13,"triangles":0,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":12},{"id":"GO:0060972","count":10},{"id":"GO:0007498","count":10},{"id":"GO:0060806","count":10},{"id":"GO:0000398","count":10}]},{"hash":"989566486913753563","title":"Mitotic Control via Ubiquitin-Proteasome Regulation","description":"This cluster is dominated by GO terms tied to mitosis and cell-cycle progression (G2/M transition, chromosome segregation, exit from mitosis, mitotic cell cycle) plus ubiquitin-proteasome\u2013related processes (SCF-dependent degradation, autoubiquitination, ERAD) and chromatin organization, with additional links to DNA repair. The strong co-occurrence of these themes suggests proteins function together to regulate mitosis through targeted proteolysis and chromatin dynamics, occasionally intersecting viral manipulation of ubiquitin systems.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0000086","count":14},{"id":"GO:0007059","count":14},{"id":"GO:0016032","count":14},{"id":"GO:0031146","count":14},{"id":"GO:0070911","count":14}]},{"hash":"1167559973728691364","title":"Embryonic neural and organ morphogenesis","description":"This cluster centers on GO terms related to broad embryonic development and organogenesis, including neural development (midbrain/metencephalon, neural crest migration, amacrine cell differentiation) and morphogenesis of various organs (pancreas, digestive tract, cartilage, ureteric bud). The common theme is developmental processes shaping tissues and organs, with a notable emphasis on neural-related development, hence the label Embryonic neural and organ morphogenesis.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":7},{"id":"GO:0031018","count":6},{"id":"GO:0001755","count":6},{"id":"GO:0090190","count":6}]},{"hash":"221019675193202543","title":"Unknown","description":"The top GO terms are highly diverse, spanning ion transport regulation, cell cycle regulation, multiple lipid/bacterial metabolite biosynthesis processes, and various immune-related responses, many of which are obsolete. There is no coherent, shared biological function linking these terms, suggesting either heterogeneous functions or annotation noise rather than a single cluster theme.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002028","count":3},{"id":"GO:0070317","count":2},{"id":"GO:0019746","count":2},{"id":"GO:0034097","count":2},{"id":"GO:0010035","count":2}]},{"hash":"229051280196216786","title":"Enteric nervous system and gut-brain signaling","description":"This cluster shows GO terms tied to the enteric nervous system (enteric nervous system development, peristalsis, saliva secretion) and neural signaling (dopaminergic synaptic transmission, brain renin-angiotensin system). Additional terms related to metabolic/thermal responses (diet-induced thermogenesis, cellular response to temperature stimulus) further suggest a gut\u2013brain axis theme and neural control of GI function. Overall, the common thread is nervous system regulation of GI motility and related feeding/metabolic signaling.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0030432","count":7},{"id":"GO:0042493","count":7},{"id":"GO:0002024","count":7},{"id":"GO:0048484","count":7},{"id":"GO:0071502","count":7}]},{"hash":"1154895620600416704","title":"Adrenergic and Dopaminergic Neural Signaling","description":"The terms cluster around brain/neural signaling, especially dopaminergic synaptic transmission and adrenergic receptor signaling pathways (MAPK and phospholipase C activation), plus norepinephrine-epinephrine\u2013related vascular effects and brain renin-angiotensin system activity, suggesting a cohesive theme of neural GPCR-mediated signaling. A few outliers (thymocyte differentiation) are present but do not strongly counter the main neural signaling pattern.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"2085801660665230820","title":"Cell Cycle Regulation and DNA Replication","description":"The GO terms cluster around G1/S transcriptional regulation, initiation of DNA replication, G1 DNA damage checkpoint signaling, and spindle assembly, all central to cell cycle control and chromosome segregation. Proteasomal ubiquitin-dependent protein catabolic process supports regulated protein turnover driving these processes, with some stress-response annotations appearing as secondary associations. Confidence: High.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000083","count":9},{"id":"GO:1903378","count":9},{"id":"GO:0021993","count":9},{"id":"GO:0030174","count":9},{"id":"GO:0031571","count":9}]},{"hash":"1615927454710643871","title":"Innate immune signaling and ECM remodeling","description":"This cluster is enriched for innate immune terms: defense response to Gram-positive bacterium, antibacterial humoral response, innate immune response, and MyD88-dependent TLR signaling pathway, suggesting a core module of host defense. The presence of collagen fibril organization and integrin-mediated signaling indicates concurrent extracellular matrix remodeling and cell adhesion contexts, which often accompany immune cell activation and mechanotransduction (cellular response to mechanical stimulus). The protein homotrimerization term may reflect assembly of immune complexes or signaling complexes; positive regulation of inflammatory response aligns with the immune theme. Overall, the dominant signal is innate immune activation with supportive ECM/mechanical coupling signals.","confidence":"High","size":14,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":4},{"id":"GO:0070207","count":3},{"id":"GO:2001046","count":3},{"id":"GO:0019731","count":3},{"id":"GO:0051965","count":2}]},{"hash":"2105703137473680926","title":"ECM Remodeling and Immune Signaling","description":"The GO terms cluster around extracellular matrix-related processes (angiogenesis; glomerular basement membrane development) and immune activities (complement activation; phagocytosis; regulation of T cell signaling). Additional terms point to Golgi/localization and membrane trafficking, suggesting secretory pathways for ECM components and membrane organization that support both ECM remodeling and immune responses. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:1903077","count":2},{"id":"GO:0051645","count":2},{"id":"GO:0000187","count":2},{"id":"GO:0006911","count":2}]},{"hash":"519866463643679751","title":"Craniofacial skeletal development and ECM organization","description":"The proteins show a coherent emphasis on developmental processes\u2014especially embryonic cranial skeleton morphogenesis, ossification, and heart and nervous system development\u2014along with collagen fibril organization and cell adhesion. This pattern points to coordinated craniofacial skeletal morphogenesis and extracellular matrix (ECM) remodeling, with collagen organization underpinning bone formation, making the label specific and representative. Some terms like innate immune response and STAT signaling appear tangential, but do not override the dominant skeletal/ECM theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0048701","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0042511","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2021107635551024533","title":"Cell adhesion and signaling","description":"The cluster centers on adhesion-related processes and cell\u2013cell/matrix interactions: cell adhesion, regulation of integrin-mediated cell-cell adhesion, and endothelial cell migration\u2014all of which depend on adhesion to the extracellular matrix and coordinated signaling. Proteolysis can remodel the ECM to permit adhesion and migration, and diacylglycerol catabolic processes fit into lipid signaling pathways that drive adhesion-related signaling. Additional terms like T cell costimulation and regulation of insulin secretion reflect broader cell\u2013cell communication contexts. There is an outlier term (cellulose catabolic process) that doesn\u2019t fit the core theme, but the dominant pattern supports an adhesion-and-signaling focus.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030245","count":8},{"id":"GO:0098869","count":8},{"id":"GO:0043542","count":6},{"id":"GO:0035641","count":6},{"id":"GO:0050796","count":6}]},{"hash":"1641752152900925115","title":"Unknown","description":"The terms span several unrelated processes, including intracellular transport, rRNA processing, metabolism, sporulation, pattern formation, and isotype switching, with no single unifying function across the proteins. Because there isn\u2019t a cohesive theme tying these GO terms together, there isn\u2019t a reliable, specific label to assign beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000232","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0006886","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0006541","count":1}]},{"hash":"779235407665178988","title":"Ribosome biogenesis and cell growth","description":"This cluster\u2019s top terms center on ribosome biogenesis, cell division/growth, and nuclear pore localization, suggesting a shared role in protein synthesis machinery and proliferation, with immune-related terms being less represented.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0031081","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0042254","count":2}]},{"hash":"1430199268049968111","title":"Plant glycoprotein and cell wall polysaccharide biosynthesis","description":"This cluster is dominated by GO terms related to glycosylation and glycan metabolism (arabinogalactan protein metabolic process, O-linked glycosylation via hydroxyproline, Lewis a epitope biosynthesis) and seed coat/mucilage biosynthesis, pointing to plant cell wall glycoprotein and polysaccharide biosynthesis as the core function. Some terms may be broader or noisy annotations, but the glycosylation/glycan theme is clear and representative.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0075015","count":3},{"id":"GO:0006688","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0061014","count":2},{"id":"GO:0001744","count":2}]},{"hash":"2116024149583061240","title":"Neural adrenergic signaling and thermogenesis","description":"The top terms cluster around dopaminergic synaptic transmission, adrenergic receptor signaling, and temperature-related responses (diet-induced thermogenesis, cellular response to temperature stimulus). This points to neural regulatory pathways controlling thermogenesis and associated cardiovascular/brain signaling, with a few outliers like thymocyte differentiation not altering the overall theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0002035","count":13},{"id":"GO:0001963","count":13}]},{"hash":"730750370742570893","title":"Brain adrenergic-dopaminergic GPCR signaling","description":"The top GO terms center on brain-specific signaling involving dopaminergic synaptic transmission, adrenergic receptor pathways, and MAPK activation, along with brain renin-angiotensin system activity and vasoconstriction\u2014pointing to a neuro GPCR signaling module governing adrenergic/dopaminergic communication and associated vascular regulation. Some immune-related terms appear as peripheral associations to GPCR signaling, but the core theme is neuronal GPCR signaling in the brain.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":14},{"id":"GO:0001963","count":14},{"id":"GO:1900453","count":14},{"id":"GO:0001994","count":14},{"id":"GO:0071883","count":14}]},{"hash":"13437800447206984","title":"Brain adrenergic and dopaminergic signaling","description":"This cluster centers on GPCR-mediated neural signaling, especially adrenergic receptor pathways (MAPK and PLC activation) and dopaminergic synaptic transmission, plus brain-related cardiovascular regulation such as norepinephrine/epinephrine\u2013driven vasoconstriction and the brain renin-angiotensin system. Some terms about immune development appear as noise, but the dominant theme is neural signaling in the brain linked to cardiovascular regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":14},{"id":"GO:0001963","count":14},{"id":"GO:1900453","count":14},{"id":"GO:0001994","count":14},{"id":"GO:0071883","count":14}]},{"hash":"183847333565623326","title":"Ubiquitin-Dependent Proteolysis & Signaling","description":"The cluster is dominated by GO terms related to ubiquitination and ubiquitin-linked degradation (ubiquitin-dependent protein catabolic process, ERAD, autoubiquitination, and various ubiquitin linkages like K6 and K63), along with regulatory signaling terms (JNK cascade and TNF-mediated signaling). This suggests a cohesive function in ubiquitin-mediated proteolysis coupled to signaling pathways. Some terms are listed as obsolete, but the core theme remains ubiquitin-driven processes.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":4},{"id":"GO:0046328","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0051865","count":3}]},{"hash":"279663694746651049","title":"Innate Antiviral Immunity and RNA Regulation","description":"The top GO terms point to innate immune signaling, interferon regulation, antiviral control of viral RNA replication, MHC class I biosynthesis, RNA silencing, and stress granule localization, suggesting a cohesive theme of antiviral defense combined with RNA processing/regulation. Some terms are obsolete, but the overall pattern supports a defense-oriented, RNA-centric cluster.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0032479","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0045345","count":1},{"id":"GO:0045869","count":1}]},{"hash":"332874393638069680","title":"Chemosensory and Neuropeptide Signaling","description":"Top terms include sensory perception of chemical stimuli (pheromone and taste/bitter), neuropeptide signaling, and dopamine receptor signaling, indicating a cluster centered on neural chemosensory perception and neuropeptide-mediated signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":4},{"id":"GO:0007606","count":4},{"id":"GO:0032720","count":3},{"id":"GO:0007218","count":3},{"id":"GO:0008283","count":3}]},{"hash":"1481769908351614647","title":"Coagulation and Collagen/ECM Regulation","description":"The top GO terms point to coagulation, collagen fibril organization and biosynthesis, and regulation of fibrinolysis/plasminogen activation, suggesting a shared role in extracellular matrix remodeling and blood clotting. Some neural terms (short-term memory, synapse assembly) appear, but the stronger signals are ECM/hemostasis related, so the cluster likely reflects connective tissue and clotting pathways rather than neural function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":3},{"id":"GO:1902430","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0007614","count":3}]},{"hash":"57280541620748106","title":"Embryonic patterning and organogenesis","description":"The top GO terms cluster around left-right pattern formation, embryonic placenta development, endocrine system development, trophoblast giant cell and pancreatic cell differentiation, EMT in heart development, and cartilage morphogenesis, indicating a cohesive theme of developmental patterning and tissue morphogenesis across multiple organ systems.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":13},{"id":"GO:0060806","count":13},{"id":"GO:0035270","count":13},{"id":"GO:0060707","count":13},{"id":"GO:0003323","count":13}]},{"hash":"552826337662483656","title":"Cell division and membrane trafficking regulators","description":"The GO terms cluster around mitotic control and membrane/cytoskeletal dynamics (metaphase/anaphase transition, centrosome maintenance, Rho signaling, endocytic recycling, membrane tubulation, thrombin receptor signaling), suggesting a common theme of coordinating cell division with trafficking and signaling. Some terms (bone mineralization, B cell activation, mRNA processing) are less directly linked, but appear as peripheral associations in this dataset.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0007091","count":2},{"id":"GO:2001137","count":2},{"id":"GO:0051661","count":2},{"id":"GO:0070493","count":2}]},{"hash":"2280588253248642357","title":"Unknown","description":"The GO terms span neural development, sensory regulation, fertilization, folate transport, growth factor signaling, and protein lipidation, with no evident shared function or connection among the proteins (no edges/triangles). Therefore a cohesive label cannot be assigned; Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050884","count":2},{"id":"GO:0010839","count":2},{"id":"GO:0071231","count":2},{"id":"GO:1904657","count":2},{"id":"GO:0003147","count":2}]},{"hash":"2005132503969617869","title":"DNA Damage Response and Cell Fate Signaling","description":"Top GO terms point to DDR/mitosis (homologous recombination repair and spindle assembly) together with programmed cell death (apoptosis, pyroptosis) and immune signaling (innate response, ubiquitination). This suggests a cohesive theme around maintaining genomic stability and relaying stress signals to decide cell fate, including inflammatory outcomes. Some terms are broad or obsolete, but the core linkage remains DDR-associated pathways and cell fate regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090307","count":6},{"id":"GO:0000724","count":5},{"id":"GO:0048568","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0045087","count":4}]},{"hash":"1812528488270592815","title":"Ubiquitin-Proteasome Regulation and ERAD Control","description":"The cluster centers on ubiquitin-related processes, including ER-associated degradation (ERAD) and deubiquitination regulation, with multiple terms pointing to negative regulation of ERAD and ubiquitin-associated activities. Additional terms touch on related proteostasis and cell-cycle-related functions (nuclear membrane reassembly, cell death), suggesting a cohesive theme around ubiquitin-mediated protein quality control rather than a single isolated pathway. Some terms are obsolete, but the core signal remains proteostasis and ERAD-centric. ","confidence":"Medium","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0034389","count":4},{"id":"GO:2000157","count":4},{"id":"GO:0031468","count":4},{"id":"GO:0031134","count":4}]},{"hash":"465556374955022471","title":"Brain adrenergic and dopaminergic signaling","description":"This cluster is dominated by GO terms related to adrenergic and dopaminergic neurotransmission in the brain, including adrenergic receptor signaling pathways (MAPK-activating and phospholipase C-activating), dopaminergic synaptic transmission, and brain-specific processes like the brain renin-angiotensin system and blood pressure regulation, suggesting a cohesive theme of neurochemical GPCR signaling and synaptic modulation. While a few immune-related terms appear, the central pattern centers on neural signaling pathways.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":4},{"id":"GO:0001963","count":4},{"id":"GO:1900453","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0071883","count":4}]},{"hash":"1207592110376075408","title":"RNA Processing and Stress Response","description":"This cluster centers on RNA metabolism and transcription-linked processes, including ncRNA-mediated gene silencing, spliceosome-driven splicing, and regulation of mRNA stability under stress, plus localization to cytoplasmic stress granules and transcription-associated repair. The convergence on RNA processing and stress-related regulation justifies the label.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0000398","count":7},{"id":"GO:0010610","count":7},{"id":"GO:1903608","count":7}]},{"hash":"1089876619819919863","title":"Transsulfuration and H2S biosynthesis","description":"The cluster prominently features GO terms for hydrogen sulfide biosynthesis, transsulfuration, and homocysteine catabolism, which together point to sulfur amino acid metabolism and H2S production. While other terms like fatty acid and carbohydrate biosynthesis or protein kinase activation appear, the strongest coherent signal is sulfur metabolism related to cysteine/homocysteine pathways, supporting a focused label on transsulfuration and H2S biosynthesis.","confidence":"Medium","size":13,"edges":6,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070814","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0043418","count":5},{"id":"GO:0019346","count":5},{"id":"GO:0006535","count":5}]},{"hash":"1346178140758956882","title":"Unknown","description":"These proteins have a highly heterogeneous set of GO terms, including developmental processes (angiogenesis, cardiac neural crest development), immune responses (dsRNA and muramyl dipeptide sensing), biofilm formation, apoptotic signaling, filamentous growth signaling, and spindle assembly regulation. There's no single cohesive function or pathway tying these terms together, and some terms are obsolete, suggesting annotation noise. Therefore no specific, representative label can be assigned. ","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":12},{"id":"GO:0090606","count":12},{"id":"GO:0000186","count":12},{"id":"GO:0061308","count":12},{"id":"GO:0001525","count":12}]},{"hash":"203177756966098827","title":"Mitotic Chromosome Maintenance and Ribosome Biogenesis","description":"This cluster is enriched for mitosis- and chromosome-maintenance processes: cell division, CENP-A chromatin assembly, mitotic sister chromatid cohesion, and homologous recombination repair. The presence of ribosome biogenesis terms alongside these suggests a coordinated role in growth and protein synthesis during cell division. Overall, the proteins appear to support accurate chromosome segregation together with ribosome biogenesis.","confidence":"High","size":13,"edges":33,"triangles":64,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0042254","count":9},{"id":"GO:0030433","count":8},{"id":"GO:0051260","count":8},{"id":"GO:0061641","count":8}]},{"hash":"2094499034767406580","title":"Cardiovascular Development and Angiogenesis","description":"The strongest common thread among the top terms is angiogenesis and heart development (angiogenesis; cardiac neural crest cell development involved in heart development), indicating a cardiovascular development module. While there are other terms spanning signaling, cell cycle, and immune responses, those appear less central to the cluster\u2019s core theme. This makes the label Cardiovascular Development and Angiogenesis a concise and representative description, with some annotation noise from unrelated terms.","confidence":"Medium","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":13},{"id":"GO:0090606","count":13},{"id":"GO:0000186","count":13},{"id":"GO:0061308","count":13},{"id":"GO:0001525","count":13}]},{"hash":"1876016127634041022","title":"Neural development and mechanosensory signaling","description":"This cluster centers on neuronal development and mechanosensory functions, with multiple terms for neuron differentiation, neuron migration, and mechanosensory detection/behavior, supported by cytoskeletal processes like microtubule nucleation and spindle midzone assembly, suggesting a module focused on neural development coordinated with cytoskeletal dynamics.","confidence":"Medium","size":13,"edges":73,"triangles":237,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0007049","count":5},{"id":"GO:0001764","count":5},{"id":"GO:1905789","count":5},{"id":"GO:0030182","count":5}]},{"hash":"214146255624016834","title":"Germline development and meiotic DNA repair","description":"The cluster centers on germ cell development (spermatid development; germarium-derived oocyte fate) and meiotic DNA repair (double-strand break repair in meiotic recombination; replication-born DSB repair via SCE), with related transcriptional activity and apoptotic regulation and several DNA-damage responses to cisplatin and camptothecin. This combination strongly suggests a module linking germline differentiation to meiotic DNA repair pathways, with some associated stress responses.","confidence":"High","size":13,"edges":38,"triangles":47,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0007286","count":4},{"id":"GO:0009636","count":4},{"id":"GO:0007294","count":3},{"id":"GO:0072719","count":3}]},{"hash":"1624264837421277848","title":"Neuronal morphogenesis and synapse assembly","description":"The cluster\u2019s top GO terms center on neuronal development and synaptic formation (neuron projection morphogenesis, synapse assembly) with supporting cytoskeletal remodeling (podosome assembly, actin crosslink formation) and signaling (insulin receptor signaling, small GTPase signaling). Translation initiation regulation hints at local protein synthesis at neurons/synapses, reinforcing a neuronal growth and connectivity theme. Some terms are peripheral (Golgi glycosylation, fatty acid oxidation) but do not alter the core neuronal morphogenesis signal.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0008286","count":7},{"id":"GO:0007264","count":7},{"id":"GO:0071800","count":7},{"id":"GO:0051764","count":7},{"id":"GO:0007416","count":7}]},{"hash":"1527430323947163510","title":"Mitochondrial transport and membrane dynamics","description":"The cluster shows multiple transmembrane transport activities for mitochondrial and cellular metabolites (NAD, ornithine, glycine, thiamine pyrophosphate, deoxynucleotides) and processes that regulate mitochondrial membrane permeability and fission, along with related survival signals such as necroptosis regulation. This combination suggests a cohesive role in mitochondrial transport and membrane maintenance, justifying the label.","confidence":"Medium","size":13,"edges":13,"triangles":2,"max_degree":5,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0035352","count":5},{"id":"GO:0034198","count":5},{"id":"GO:0000066","count":5},{"id":"GO:0097421","count":5},{"id":"GO:0036233","count":5}]},{"hash":"1231616810329353581","title":"Actin Cytoskeleton Remodeling and Lamellipodium Formation","description":"The top GO terms cluster around actin dynamics and lamellipodium biology (lamellipodium assembly, actin filament bundle assembly, actin filament polymerization, positive regulation of actin nucleation, barbed-end capping, and lamellipodium morphogenesis), indicating a focus on actin-driven protrusions and cytoskeletal remodeling. The presence of COPII-coated vesicle cargo loading and neutrophil degranulation regulation suggests coupling between actin remodeling and vesicle trafficking/secretion, common in motile or secretory cells. Overall, this cluster likely represents proteins coordinating actin-based lamellipodia with vesicle trafficking functions.","confidence":"High","size":13,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0090110","count":3},{"id":"GO:2000394","count":3},{"id":"GO:0030041","count":2}]},{"hash":"2247529903608450573","title":"Endocytosis and apoptosis regulation","description":"This cluster centers on vesicle trafficking and endocytosis-related processes (clathrin coat assembly, receptor-mediated endocytosis, protein targeting to vacuole) and links to apoptotic signaling (mitochondrial outer membrane permeabilization, amyloid-beta formation). The co-occurrence of these terms suggests a shared theme where vesicle trafficking and cytoskeletal regulation intersect with apoptosis and proteostasis, despite some terms being less directly connected (e.g., gastric acid secretion). ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060453","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0098711","count":3},{"id":"GO:0034316","count":3},{"id":"GO:0006623","count":3}]},{"hash":"543383464238019117","title":"RNA splicing and mRNA maturation","description":"The top terms cluster around post-transcriptional RNA processing: spliceosome-mediated mRNA splicing, mRNA polyadenylation (including mitochondrial), regulation of mRNA stability under stress, and links to miRNA-mediated gene silencing. This suggests a cohesive module of RNA maturation and post-transcriptional control, despite a few obsolete terms. ","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0000398","count":7},{"id":"GO:0006378","count":6},{"id":"GO:0045292","count":6},{"id":"GO:0033129","count":5}]},{"hash":"418209394493395462","title":"Redox Metabolism and Stress Response","description":"The cluster's top GO terms cluster around redox chemistry and metabolism: oxidation-reduction, TCA cycle, ferredoxin metabolism, and response to hydrogen peroxide. These indicate central metabolic activity and oxidative stress handling, typical of microbial or anaerobic metabolism. Some terms (lactation and negative regulation of VEGF signaling) appear as outliers, suggesting annotation noise or broader functional links rather than core theme.","confidence":"Medium","size":13,"edges":74,"triangles":246,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006099","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0009399","count":2},{"id":"GO:0006814","count":2}]},{"hash":"1289293792343445456","title":"Organelle fission and ribosome biogenesis","description":"The top terms cluster around organelle division (mitochondrial membrane fission, peroxisome fission) and ribosome assembly/export (ribosomal large subunit export from nucleus, ribosomal small subunit biogenesis), with some broader cell division references (cell division, cell septum assembly). This suggests a theme linking organelle dynamics to the protein synthesis machinery, even though the mix is broad. ","confidence":"Medium","size":13,"edges":10,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0022417","count":3},{"id":"GO:0090149","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0016559","count":2},{"id":"GO:1901001","count":2}]},{"hash":"131826738933304922","title":"Polyamine biosynthesis and transport","description":"The cluster is centered on polyamine metabolism: putrescine and spermidine biosynthesis, including related routes (from arginine via ornithine) and transport regulation. Some terms (kidney development, trans-Golgi network organization, L-lysine biosynthesis) may reflect broader cellular context or annotation noise, but the shared theme is polyamine synthesis and transport.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0098629","count":5},{"id":"GO:0009089","count":5},{"id":"GO:0008295","count":5},{"id":"GO:1902269","count":5}]},{"hash":"2264995685782771216","title":"Cytoplasmic translation and mRNA decay regulation","description":"The cluster is driven by strong enrichment in cytoplasmic translation and multiple mRNA decay pathways (deadenylation-dependent/independent), pointing to post-transcriptional control of gene expression. Additional terms reflect related signaling contexts (small GTPase signaling, ERK cascade) and epithelial polarity, suggesting a cohort of proteins involved in RNA metabolism with linked signaling roles rather than a single, cohesive pathway. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0002181","count":3},{"id":"GO:0007264","count":2},{"id":"GO:0090162","count":2},{"id":"GO:1900153","count":2},{"id":"GO:0042129","count":2}]},{"hash":"1026120064888251914","title":"Unknown","description":"The GO terms cover bone morphogenesis/mineralization, interferon responses, endosome-to-plasma membrane transport, insulin-stimulated glucose import, synaptic vesicle clustering, and neuromuscular control, plus host-symbiont interaction. They do not point to a single cohesive function or pathway for the cluster, making a specific label unreliable.","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009607","count":1},{"id":"GO:0060349","count":1},{"id":"GO:0035456","count":1},{"id":"GO:0099638","count":1},{"id":"GO:0035455","count":1}]},{"hash":"388798902090330988","title":"Synaptic vesicle fusion and neurotransmitter secretion","description":"This cluster is dominated by GO terms centered on vesicle fusion/exocytosis and modulation of synaptic transmission (e.g., synaptic vesicle fusion, positive regulation of excitatory postsynaptic potential, spontaneous neurotransmitter secretion), indicating a core theme of regulated secretion at neuronal synapses. The additional terms point to broader secretory/exocytotic processes in other cell types (acrosome reaction, eosinophil degranulation, Golgi vesicle transport), but the strongest signal is neuronal vesicle fusion and neurotransmitter release. ","confidence":"Medium","size":13,"edges":32,"triangles":23,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:2000463","count":10},{"id":"GO:0001916","count":9},{"id":"GO:0010811","count":9},{"id":"GO:0007340","count":9},{"id":"GO:0043311","count":9}]},{"hash":"1237601709457517939","title":"Cross-tissue organogenesis","description":"The top GO terms point to developmental specification and morphogenesis across multiple tissues (muscle, nerve, sensory organ, kidney), suggesting proteins involved in tissue differentiation and organ development rather than a single tissue function. A few immune-related terms appear but do not define the main theme.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007518","count":13},{"id":"GO:0006959","count":13},{"id":"GO:0042491","count":13},{"id":"GO:0072282","count":13},{"id":"GO:0014707","count":13}]},{"hash":"1881001215372146364","title":"Unknown","description":"The top GO terms span diverse processes including drug response, vesicle trafficking, mitochondrial inheritance, kinase signaling, Rap signaling, immune cell aggregation and chemotaxis, glial differentiation, cell fusion, and NF-kappaB regulation. This breadth suggests no single cohesive function defining the cluster, so a specific label cannot be confidently assigned.","confidence":"","size":13,"edges":49,"triangles":87,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097327","count":13},{"id":"GO:0048227","count":13},{"id":"GO:0000001","count":13},{"id":"GO:0045859","count":13},{"id":"GO:0032486","count":13}]},{"hash":"1922455927800780196","title":"Neural and Hair Follicle Development Signaling","description":"This cluster centers on developmental signaling across nervous system and epithelial tissues, with terms like nervous system development, hair follicle morphogenesis, salivary gland formation, and lung morphogenesis. The presence of positive regulation of Wnt signaling and ERK cascades suggests a shared developmental signaling program driving morphogenesis in neural and epithelial contexts, including hair follicles and glands.","confidence":"High","size":13,"edges":72,"triangles":231,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043524","count":9},{"id":"GO:0071338","count":9},{"id":"GO:0060661","count":9},{"id":"GO:0021762","count":9},{"id":"GO:0007399","count":9}]},{"hash":"193451102046083973","title":"Dopaminergic GPCR signaling and neural migration","description":"The cluster is dominated by GO terms for GPCR signaling and dopamine-related responses, including cellular response to dopamine and positive regulation of dopamine receptor signaling, along with tangential neural migration from the subventricular zone to the olfactory bulb. This points to a cohesive theme of dopaminergic signaling guiding neural development and neuronal migration, with some additional immune and mechanotransduction signals likely reflecting broader cross-talk. ","confidence":"High","size":13,"edges":17,"triangles":1,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":9},{"id":"GO:0042088","count":9},{"id":"GO:0022028","count":9},{"id":"GO:0007186","count":9},{"id":"GO:1903125","count":8}]},{"hash":"862928275780473909","title":"Ubiquitin-Proteasome\u2013Driven Stress Response","description":"Based on GO terms, the cluster centers on ubiquitin-dependent protein catabolism (including SCF-dependent proteasomal degradation) and cellular stress signaling (response to methylmercury/arsenic) with links to cell cycle and DNA replication regulation. Although a few terms touch development (neural tube closure) and circadian rhythm, the dominant signals point to protein turnover and stress-response pathways that govern proteostasis under challenging conditions. The label thus reflects the core function of protein quality control and stress adaptation represented in this cluster.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0000083","count":7},{"id":"GO:1903378","count":7},{"id":"GO:0021993","count":7},{"id":"GO:0030174","count":7}]},{"hash":"1168081412500310588","title":"Leukocyte Recruitment and Inflammatory Signaling","description":"This cluster shows strong representation of GO terms tied to innate immune activation and leukocyte trafficking\u2014neutrophil chemotaxis, leukocyte migration, leukocyte adhesive activation, and lipopolysaccharide/lipoteichoic acid signaling. Growth factor/hormone responses (FGF, estradiol) and angiogenesis are also present, suggesting inflammation-driven vascular remodeling. Overall, the theme is inflammatory signaling that promotes leukocyte recruitment.","confidence":"High","size":13,"edges":38,"triangles":59,"max_degree":11,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0044344","count":8},{"id":"GO:0071392","count":8},{"id":"GO:0090023","count":7},{"id":"GO:0071223","count":7},{"id":"GO:0002523","count":7}]},{"hash":"947790650622634211","title":"Mitotic spindle assembly and checkpoint","description":"The top GO terms cluster around mitosis: establishment of spindle orientation, activation of the spindle assembly checkpoint, and attachment of spindle microtubules to kinetochores, all core to mitotic progression. A general mitotic cell cycle term reinforces this theme. A few other terms (cell adhesion, development, oligomerization) are not central to this theme and may reflect multifunctional proteins, but the dominant signal is clearly mitotic spindle and checkpoint functions.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":2},{"id":"GO:0090268","count":2},{"id":"GO:0051315","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0007155","count":2}]},{"hash":"423996395884545519","title":"Transcription and Translation Regulation","description":"This cluster centers on gene expression control, with GO terms for DNA-templated transcription and transcription regulation (RNA Pol II) plus translation-related terms (translation and positive regulation of cytoplasmic translation). While some terms are obsolete, the dominant theme is regulation of transcription and translation, suggesting a cohesive expression-regulation function.","confidence":"Medium","size":13,"edges":18,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0010729","count":2},{"id":"GO:0046022","count":2},{"id":"GO:0007576","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1905198529649748742","title":"Transcription and MicroRNA Processing Cluster","description":"Dominant signals are transcription-related (DNA-templated transcription, transcription antitermination, termination regulation) and RNA processing (pre-miRNA processing, miRNA catabolic process, CRD-mediated mRNA stabilization). This points to a cluster of factors involved in transcription regulation and microRNA biogenesis/turnover, with ancillary links to translation initiation and broader gene-expression control. Therefore the label Transcription and MicroRNA Processing Cluster captures the core function.","confidence":"High","size":13,"edges":7,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1902219","count":5},{"id":"GO:0070934","count":5},{"id":"GO:0031564","count":5},{"id":"GO:1901724","count":5},{"id":"GO:0006351","count":5}]},{"hash":"889915487879067055","title":"Translation and protein folding machinery","description":"This cluster is strongly enriched for translation (protein synthesis) and protein folding, along with ATP-dependent activity and protein complex oligomerization, which together point to a core role in the synthesis and proper folding/assembly of proteins. The kidney development and odontogenesis terms appear peripheral or noisy in this context, but the central theme likely reflects basic cellular apparatus for producing and assembling proteins.","confidence":"Medium","size":13,"edges":7,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032781","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0042475","count":2},{"id":"GO:0097428","count":1}]},{"hash":"106647122583660022","title":"Lymphocyte signaling and mRNA decay regulation","description":"This cluster is dominated by terms related to T cell homeostasis, B cell homeostasis, and regulation of T cell proliferation, with ERK1/ERK2 cascade suggesting signaling roles in lymphocytes. In addition, multiple GO terms describe nuclear-transcribed mRNA decay pathways (deadenylation-dependent and -independent), implying coordinated post-transcriptional control of gene expression in immune cells. The heart development term is less directly connected and may reflect broader developmental functions, but the overall pattern points to immune signaling coupled with mRNA stability regulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0001782","count":3},{"id":"GO:1900153","count":2},{"id":"GO:0042129","count":2}]},{"hash":"1752399542279694166","title":"Rho/Ras GTPase signaling and cytoskeletal remodeling","description":"The cluster is dominated by small GTPase signaling terms (Rho, Ras) and processes tied to actin cytoskeleton dynamics (lamellipodium assembly, cell migration), plus endocytosis and regulation of GTPase pathways, indicating a cohesive theme of signaling-driven cytoskeletal remodeling and trafficking across diverse tissues. ","confidence":"High","size":13,"edges":16,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006897","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0016477","count":3}]},{"hash":"2184482119755645150","title":"Centromere chromatin assembly and mitotic progression","description":"The cluster shows a strong focus on CENP-A\u2013containing chromatin assembly, cell division, and microtubule-related processes, pointing to centromere function and mitotic spindle dynamics. Other terms like transcription regulation and vesicle transport appear ancillary but may reflect broader cellular activities in dividing cells.","confidence":"Medium","size":13,"edges":11,"triangles":0,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0061641","count":3}]},{"hash":"763929819399048104","title":"Neuronal RNA processing and antiviral response","description":"The cluster combines neural development signals (motor neuron apoptotic process, motor behavior, spinal cord morphogenesis) with RNA metabolism and immune signaling (mRNA processing, rRNA catabolic process, siRNA processing, eIF2\u03b1-regulated translation, interferon response, and antiviral genome regulation). This suggests proteins that function in neural development while coordinating RNA processing and innate antiviral defenses, making the label a concise reflection of the shared themes.","confidence":"Medium","size":13,"edges":50,"triangles":114,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0097049","count":7},{"id":"GO:0061744","count":7},{"id":"GO:0006397","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0010998","count":7}]},{"hash":"1101278668663142199","title":"Immune Cell Communication and Adhesion","description":"The top GO terms cluster around immune regulation and intercellular signaling: negative regulation of NK cell and macrophage activities, negative regulation of cytotoxic T cell degranulation, and positive regulation of T cell proliferation, all pointing to immune cell communication. Additional terms about cell-cell adhesion and synapse assembly reinforce a theme of immune synapse formation and cell adhesion. Some terms (mechanosensory detection, symbiont entry, AV node adhesion) are peripheral but may reflect broader adhesion or signaling roles. Overall, the cluster appears to represent immune regulation and intercellular communication via cell adhesion.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":5},{"id":"GO:0050910","count":5},{"id":"GO:0090138","count":5},{"id":"GO:0051963","count":5},{"id":"GO:0086072","count":5}]},{"hash":"676365824822650613","title":"Membrane Nutrient Transporters","description":"The top GO terms are dominated by transmembrane transport of multiple nutrients and ions (glucose, pantothenate, myo-inositol, biotin, and sodium ions), indicating a cluster of membrane transporter proteins that mediate uptake/export of diverse metabolites. While a few signaling-related terms appear, the common theme is substrate transport across the plasma membrane.","confidence":"Medium","size":13,"edges":18,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":7},{"id":"GO:0015887","count":5},{"id":"GO:0071436","count":5},{"id":"GO:0015798","count":5},{"id":"GO:0015878","count":5}]},{"hash":"703773165657690759","title":"Heart and craniofacial morphogenesis","description":"Top GO terms cluster around development and morphogenesis of heart structures, atrial septum, cartilage/facial structures, and associated vasculature, indicating a shared theme of embryonic tissue morphogenesis with a focus on cardiovascular and craniofacial development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060716","count":4},{"id":"GO:0010754","count":4},{"id":"GO:0035754","count":3},{"id":"GO:0060591","count":3},{"id":"GO:0030823","count":3}]},{"hash":"306299891198662254","title":"Retinal phototransduction and calcium signaling","description":"The top GO terms point to vision- and photoreceptor-related signaling (visual perception, regulation of opsin-mediated signaling), with a strong emphasis on calcium ion\u2013responsive signaling and phosphorylation, which are core features of phototransduction and retinal signal transduction. While terms like heart development and xenobiotic response are broader, the dominant theme across the cluster is photoreceptor signaling with calcium regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0071277","count":3},{"id":"GO:0035690","count":3}]},{"hash":"1363697809659035849","title":"Embryonic Differentiation and Organ Morphogenesis","description":"The top GO terms cluster around differentiation and morphogenesis in embryonic tissues, including trophoblast giant cell differentiation, placental development, left/right patterning, EMT in heart development, cartilage morphogenesis, and pancreatic endocrine development. This points to proteins coordinating lineage specification and organ formation during embryogenesis, with accompanying transcriptional regulation and splicing activities that support these processes.","confidence":"High","size":13,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060707","count":10},{"id":"GO:0060972","count":8},{"id":"GO:0060806","count":8},{"id":"GO:0035270","count":8},{"id":"GO:0003323","count":8}]},{"hash":"1554484223392256532","title":"Detoxification and chemical-stress response","description":"The proteins show enrichment in responses to lipopolysaccharide and copper ions, along with multiple detox/catabolic processes (formaldehyde, ethanol, furaldehyde) and central carbon metabolism (D-xylulose 5-phosphate biosynthesis, non-phosphorylated glucose catabolism). This pattern points to a general theme of metabolic adaptation to chemical stress and detoxification rather than a single, cohesive pathway.","confidence":"Medium","size":13,"edges":13,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":2},{"id":"GO:0046688","count":1},{"id":"GO:0019518","count":1},{"id":"GO:0006069","count":1},{"id":"GO:1901159","count":1}]},{"hash":"1987867789682381910","title":"mRNA decay and translation regulation","description":"The cluster\u2019s top terms are dominated by translation and RNA turnover: translation (GO:0006412), cytoplasmic translation termination (GO:0002184), deadenylation-dependent decay and decapping (GO:1900153, GO:0031087), and P-body assembly (GO:0033962). These point to coordinated control of mRNA stability and protein synthesis. There are minor ties to DNA replication and DNA damage tolerance, and a hint of antiviral RNA sensing (RIG-I signaling and interferon pathways), but the strongest pattern is mRNA processing and translation regulation, especially P-body\u2013associated decay and translational control.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0006301","count":2},{"id":"GO:0060340","count":1},{"id":"GO:1900153","count":1}]},{"hash":"686687286152545513","title":"Neural development and brain regionalization","description":"The cluster is dominated by nervous system development terms: peripheral nervous system neuron development, dopaminergic neuron differentiation, telencephalon regionalization, and metencephalon development, suggesting a coherent theme of neural differentiation and brain patterning during embryogenesis. A few terms (e.g., regulation of transcription, endoderm fate, digestive tract development) may reflect broader regulatory roles of these proteins or pleiotropy, but the strongest signal points to neural development and brain regional specification.","confidence":"High","size":13,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0048935","count":11},{"id":"GO:0090009","count":11},{"id":"GO:0000122","count":11},{"id":"GO:0048565","count":10},{"id":"GO:0071542","count":10}]},{"hash":"862569498949465283","title":"Ubiquitination and NF-\u03baB signaling in innate immunity","description":"The terms point strongly to ubiquitin-dependent proteolysis (K48-linked ubiquitination, ERAD, autoubiquitination) together with innate immune defense and positive regulation of canonical NF-\u03baB signaling, indicating a group of proteins coordinating protein degradation with antiviral immune signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0030433","count":5},{"id":"GO:1903265","count":5},{"id":"GO:0070936","count":5},{"id":"GO:0045087","count":4}]},{"hash":"1007182509210904638","title":"Neurodevelopment and organogenesis","description":"The GO terms point to developmental processes across the nervous system (metencephalon development, telencephalon regionalization, spinal cord neuron differentiation) and various organs (heart, pancreas, digits, ureteric bud), indicating a broad embryonic development theme with emphasis on neural development and organ formation. Hence, a concise label capturing both neurodevelopment and organogenesis fits well.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":13},{"id":"GO:1902870","count":13},{"id":"GO:0042663","count":13},{"id":"GO:0002087","count":13},{"id":"GO:0021978","count":13}]},{"hash":"1713452136498238769","title":"Embryonic morphogenesis and cell adhesion regulation","description":"The top GO terms heavily point to developmental processes (axial mesoderm morphogenesis, embryonic foregut morphogenesis) and cell adhesion/ECM interactions (regulation of integrin activation, podosome assembly, paranodal junction assembly, membrane docking, TGF-beta\u2013stimulated signaling). While a few terms (glucose absorption, antibacterial peptide regulation) seem peripheral, the dominant theme is embryonic tissue morphogenesis and adhesion/migration. Therefore, a label emphasizing embryonic morphogenesis and adhesion is appropriate.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0048319","count":13},{"id":"GO:0048617","count":13},{"id":"GO:0001951","count":12},{"id":"GO:0071560","count":12},{"id":"GO:0022614","count":12}]},{"hash":"2139834930750840556","title":"Unknown","description":"The GO terms span membrane repair, innate immunity, interferon regulation, stress-granule localization, and various signaling (endocrine and cardiac) processes, with little overlap pointing to a single coherent function. Because the terms come from diverse biological contexts (cellular maintenance, immune response, endocrine signaling, and heart signaling) and only a few terms recur, there isn\u2019t a clear unifying theme to name the cluster more specifically. This suggests the proteins in this cluster do not cluster around a single dominant function based on the current annotations. Therefore, the cluster is best labeled Unknown.","confidence":"","size":13,"edges":11,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":2},{"id":"GO:0040015","count":1},{"id":"GO:0071107","count":1},{"id":"GO:2000828","count":1},{"id":"GO:0032479","count":1}]},{"hash":"619062651165750927","title":"Dopaminergic signaling and brain sensory processing","description":"The cluster\u2019s top GO terms point to neuronal signaling and sensory/behavioral functions, including dopaminergic synaptic transmission, GPCR signaling, cocaine-related behavioral response, visual perception, and visual learning. Brain renin-angiotensin activity and prostaglandin response reinforce a neuroendocrine signaling theme, while protein phosphorylation and electron transport reflect neuronal activity and metabolism. Taken together, these terms suggest a coherent focus on brain signaling, learning, and sensory processing, with a few broader or peripheral annotations.","confidence":"High","size":13,"edges":50,"triangles":75,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:0007507","count":12},{"id":"GO:0007601","count":12},{"id":"GO:0010579","count":12}]},{"hash":"1471499838759617036","title":"Adrenergic signaling and autonomic regulation","description":"This cluster centers on adrenergic receptor\u2013mediated pathways (MAPK-activating and PLC-activating) and physiological processes tied to autonomic control, such as vasoconstriction and saliva secretion, with supporting links to dopaminergic synaptic activity and immune modulation, suggesting a cohesive theme of adrenergic signaling influencing brain function, cardiovascular regulation, and immune responses.","confidence":"High","size":13,"edges":57,"triangles":109,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046541","count":9},{"id":"GO:0002035","count":8},{"id":"GO:0001963","count":8},{"id":"GO:1900453","count":8},{"id":"GO:0001994","count":8}]},{"hash":"567091273967378574","title":"Aminoacyl-tRNA Synthetases and Translation","description":"Dominant GO terms are all about protein synthesis: translation and aminoacyl-tRNA charging, including several cytosolic and mitochondrial tRNA synthetases (Met, His, Gly, Thr, Pro) and mitochondrial tRNA aminoacylation, which together point to a cohesive translation machinery cluster. Minor terms like diadenosine tetraphosphate biosynthesis and DNA biosynthesis appear as secondary associations but do not redefine the main theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006450","count":3},{"id":"GO:0006431","count":2},{"id":"GO:0070150","count":2},{"id":"GO:0006427","count":2}]},{"hash":"741808606093372738","title":"Developmental and Immune Signaling","description":"The cluster pools proteins involved in developmental signaling (angiogenesis, cardiac neural crest\u2013related heart development) alongside immune-responsive and stress-related pathways (response to dsRNA and muramyl dipeptide, apoptosis regulation) and general cell-cycle/epigenetic regulation (histone phosphorylation, spindle assembly). This suggests a broad, cross-cutting theme of signaling and regulation spanning development and immune/stress responses.","confidence":"Medium","size":13,"edges":31,"triangles":31,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":13},{"id":"GO:0090606","count":13},{"id":"GO:0000186","count":13},{"id":"GO:0061308","count":13},{"id":"GO:0001525","count":13}]},{"hash":"1660371945047813825","title":"Cranial Nerve Axon Guidance and Neural Crest Migration","description":"These proteins are tied to axon pathfinding and cranial neural crest\u2013derived nerve development, as shown by semaphorin-plexin signaling in axon guidance, trigeminal nerve organization, branchiomotor neuron axon guidance, axonal fasciculation, and neural crest migration terms. A lone term about complement activation appears unrelated, but the dominant theme is cranial nerve axon guidance; thus the label is representative with high confidence.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902287","count":6},{"id":"GO:0021637","count":6},{"id":"GO:0021785","count":6},{"id":"GO:0043552","count":6},{"id":"GO:0048843","count":5}]},{"hash":"1877631481811998918","title":"Unknown","description":"The proteins show a highly diverse set of functions, including signaling (JNK cascade), metabolism (UDP-glucose and glycogen biosynthesis), immune defense (dsRNA response, defense against Gram-positive bacteria, xenophagy), and development (neural tube closure, organism development), with no single dominant theme tying them together.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0006011","count":2},{"id":"GO:0005978","count":2},{"id":"GO:0043330","count":2},{"id":"GO:0050830","count":2}]},{"hash":"257910668139732861","title":"Developmental Signaling and Cell Cycle Control","description":"Based on the GO terms, the cluster shows signals in ERK cascade and protein tyrosine kinase activity (signaling), developmental processes like vitellogenesis and mammary gland development, and cell cycle events such as mitosis exit and cytokinesis, plus DNA repair. This suggests a broad theme where signaling pathways interface with development and cell division, though the terms are not tightly cohesive to a single specific process.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070371","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0030879","count":2},{"id":"GO:0061098","count":2},{"id":"GO:2001275","count":2}]},{"hash":"391410296035892821","title":"Brain Adrenergic-Dopaminergic Signaling","description":"These terms converge on neural GPCR signaling and synaptic transmission in the brain: dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK and PLC pathways), brain renin-angiotensin signaling, and regulation of synaptic plasticity. A few outlier terms (immune differentiation) may reflect annotation noise, but the dominant theme is brain neurotransmission and GPCR-mediated signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":13},{"id":"GO:0001963","count":13},{"id":"GO:1900453","count":13},{"id":"GO:0001994","count":13},{"id":"GO:0071883","count":13}]},{"hash":"2183992456413308067","title":"Ubiquitin-Dependent Proteolysis and TNF Signaling","description":"The top GO terms cluster around ubiquitin-dependent protein degradation (ERAD, autoubiquitination) and inflammatory signaling (TNF-mediated pathways), plus innate immune defense. This suggests a cohesive module where ubiquitin tagging and proteasomal turnover regulate TNF signaling and antiviral responses.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0090073","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0045087","count":5}]},{"hash":"970061973464642223","title":"Cell Cycle Control and Chromatin Dynamics","description":"Most frequent terms point to mitotic cell cycle, general cell division, and regulation of cell cycle checkpoints, with supporting hints of chromatin organization and histone modification. This suggests a cluster of proteins involved in controlling cell-cycle progression and chromatin state, rather than a single specific pathway. A couple terms (obsolete ERAD-related and taste perception) seem less relevant and may reflect annotation artifacts.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0072659","count":2},{"id":"GO:1901976","count":1}]},{"hash":"2029677324133385758","title":"Adrenergic GPCR signaling and BP regulation","description":"Based on the top GO terms, this cluster centers on adrenergic receptor signaling that activates adenylate cyclase and MAPK pathways, with downstream effects on blood pressure and vascular tone (norepinephrine/epinephrine\u2013mediated vasoconstriction). It also includes dopaminergic synaptic transmission and the brain renin-angiotensin system, suggesting catecholaminergic signaling in brain and vasculature. A metabolic term (electron transport chain) may reflect energy needs of neurons, but does not override the dominant signaling theme. Overall, the proteins appear to form a coherent group around adrenergic signaling and cardiovascular regulation. ","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":13},{"id":"GO:0022900","count":13},{"id":"GO:0007190","count":13},{"id":"GO:0035025","count":13},{"id":"GO:0045777","count":13}]},{"hash":"246848551823027248","title":"Brain Adrenergic Signaling and Dopaminergic Transmission","description":"The cluster is dominated by GO terms for brain renin-angiotensin system, dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK-activating and PLC-activating), and norepinephrine-epinephrine\u2013driven vasoconstriction regulating systemic arterial blood pressure. Together these define a neuronal signaling module centered on adrenergic/dopaminergic communication and vascular regulation. A couple of immune-related terms (DN2 thymocyte differentiation, neutrophil chemotaxis) are present but not central to the main theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":13},{"id":"GO:0001963","count":13},{"id":"GO:1900453","count":13},{"id":"GO:0001994","count":13},{"id":"GO:0071883","count":13}]},{"hash":"1668109757628380286","title":"Vision- and Heart-Related GPCR Signaling","description":"The top GO terms cluster around GPCR-mediated signaling and second messengers (Ca2+, cAMP), including opsin signaling and visual perception, with additional heart development and cell proliferation terms. This suggests a common theme of GPCR-driven signaling affecting both vision-related pathways and cardiac development, tied together by Ca2+/cAMP signaling and phosphorylation dynamics.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0051281","count":4},{"id":"GO:0022400","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0006468","count":4}]},{"hash":"1109022194130650704","title":"Unknown","description":"GO terms span antiviral/antibacterial defense, interferon signaling, neural development and dopamine response, and ECM/meristem processes, with no single unifying function or apparent interaction pattern; therefore Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043330","count":4},{"id":"GO:0050830","count":4},{"id":"GO:1903351","count":4},{"id":"GO:0045359","count":4},{"id":"GO:0007409","count":4}]},{"hash":"560248281524420797","title":"ECM-Driven Cell Adhesion and Development","description":"Top GO terms emphasize extracellular matrix interactions and adhesion (cell-matrix adhesion, cell-substrate adhesion) with notable links to mesenchymal stem cell proliferation and several developmental processes (endocardial development, bone trabecula formation, embryonic eye morphogenesis). Despite some obsolete terms, the common theme is ECM-mediated adhesion signaling guiding tissue development and mesenchymal cell behavior, justifying this label as representative of the cluster.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007160","count":11},{"id":"GO:1902462","count":10},{"id":"GO:0035583","count":10},{"id":"GO:0044332","count":10},{"id":"GO:0036363","count":10}]},{"hash":"1699264560304760474","title":"Calcium signaling and muscle contraction","description":"This cluster centers on Ca2+-related signaling and muscle function: calcium release into the cytosol, regulation of mitochondrial calcium, diaphragm contraction, and cardiac electrical coupling, all pointing to Ca2+-dependent control of muscle activity. Actin crosslinking aligns with cytoskeletal changes underlying contraction. A few terms (polysaccharide catabolism, ureteric bud development) seem less connected, representing noise or broader processes.","confidence":"Medium","size":12,"edges":36,"triangles":42,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000272","count":4},{"id":"GO:0042554","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051562","count":4},{"id":"GO:0051281","count":4}]},{"hash":"2071278721743761960","title":"Actin-driven cell polarity and migration","description":"This cluster is dominated by terms tied to actin cytoskeleton remodeling (bundle assembly, branching) and polarity establishment (epithelial polarity, cell migration), with postsynaptic density assembly reflecting cytoskeletal scaffolding at specialized junctions. The combination suggests coordinated actin-driven changes that establish cell polarity and enable movement, with some signaling and synaptic scaffolding context.","confidence":"High","size":12,"edges":9,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090162","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0051017","count":6},{"id":"GO:1900042","count":5},{"id":"GO:0071560","count":5}]},{"hash":"133086959681437497","title":"DNA replication and cell cycle with proteostasis","description":"The cluster centers on core cell-cycle and DNA replication processes (leading strand elongation, replication checkpoint signaling, and cell division) while also featuring protein quality control themes (misfolded protein response, ERAD, and protein processing) and gene expression/trafficking signals (mRNA export, vesicle transport). This combination suggests a module where genome duplication and mitosis are linked with proteostasis, though some terms (like general transport) broaden the scope beyond strictly replication-focused functions.","confidence":"Medium","size":12,"edges":10,"triangles":1,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006406","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0048219","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0016485","count":5}]},{"hash":"773737565722023008","title":"Developmental differentiation and morphogenesis","description":"This cluster\u2019s top GO terms cover gonadal, neuronal, nephric duct, and plant organ development, plus regulatory processes (miRNA silencing, actin dynamics, transcription, thyroid hormone response). The common thread is broad developmental differentiation and morphogenesis across diverse systems, suggesting a role in developmental regulation rather than a single pathway. ","confidence":"Medium","size":12,"edges":49,"triangles":95,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":10},{"id":"GO:2000637","count":10},{"id":"GO:0097067","count":10},{"id":"GO:0030835","count":10},{"id":"GO:0035995","count":10}]},{"hash":"1969971871127351111","title":"Lymphoid Immune Development and Cytokine Signaling","description":"Enriched terms cluster around lymphoid immune development and cytokine signaling: CD8-positive T cell differentiation, lymphoid lineage migration into thymus, positive regulation of IFN-\u03b1/IFN-\u03b3 production, and IL-12 production, plus lipopolysaccharide-mediated signaling. These indicate proteins involved in adaptive immune development and innate cytokine responses, with a few broader terms like keratinocyte proliferation and transcription that are less specific to the immune theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043616","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0032729","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0044130","count":4}]},{"hash":"137862541282989243","title":"Regulators of NF-kB signaling and apoptosis","description":"Enrichment centers on negative regulation of canonical NF-kappaB signaling and apoptosis, with related processes like ubiquitination and receptor internalization, supporting a theme of signaling control and cell fate decisions.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043124","count":2},{"id":"GO:0002091","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0071494","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1407566910512923533","title":"PARP-Driven neural development and telomere regulation","description":"The cluster is dominated by poly-ADP-ribosylation terms (GO:0070212, GO:0070213) and includes brain development, Wnt signaling, and synaptic plasticity regulation, all of which can be influenced by PARP activity. Telomere maintenance/capping terms (GO:0032212, GO:1904355, GO:1904357) further point to PARP-related roles in telomere biology. Together, these terms suggest a cohesive theme of PARP-mediated signaling affecting neural development and telomere regulation, making this a concise and representative label for the cluster.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0007368","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0070212","count":2},{"id":"GO:1904355","count":2}]},{"hash":"1152791827056945039","title":"RNA modification and ribosome biogenesis","description":"This cluster is dominated by RNA modification and ribosome-related terms: rRNA guanine-N7 methylation, tRNA wobble uridine modification, and ribosomal small subunit export from the nucleus, pointing to RNA processing and ribosome assembly as the core theme, with additional, looser associations to biosynthetic pathways and stress/response processes.","confidence":"Medium","size":12,"edges":15,"triangles":6,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0006596","count":4},{"id":"GO:0070476","count":4},{"id":"GO:0035902","count":4},{"id":"GO:0036265","count":4}]},{"hash":"377963789825938546","title":"Heart, Vessel, Muscle, and Eye Development","description":"This cluster centers on developmental processes across the heart and vasculature (vasculogenesis, ductus arteriosus closure, and regulation of cardiac muscle differentiation/apoptosis), plus skeletal/muscle differentiation and organ morphogenesis such as optic fissure closure and enteric nervous system development. Rho signaling ties these processes to cytoskeletal dynamics and cell migration critical for morphogenesis. The terms together point to a coherent theme of embryonic development spanning cardiac, vascular, muscular, and ocular lineages, with some transcriptional regulation involved as well.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003257","count":4},{"id":"GO:0001570","count":4},{"id":"GO:0061386","count":3},{"id":"GO:0097070","count":3},{"id":"GO:2001015","count":3}]},{"hash":"1161675456968018209","title":"Cardiovascular and neural crest morphogenesis","description":"The proteins are enriched for heart development and neural crest\u2013derived structures: endocardial cushion morphogenesis, atrial septum morphogenesis, neural crest cell migration, and enteric nervous system development, plus related branching morphogenesis and Wnt signaling in heart development. These terms point to a cohesive theme of embryonic development of cardiovascular and neural crest\u2013derived tissues, with a possible ancillary link to immune regulation that does not dominate the cluster. ","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:1902262","count":4},{"id":"GO:0001755","count":3},{"id":"GO:0090190","count":3},{"id":"GO:0048484","count":3}]},{"hash":"1213049092464354660","title":"Ubiquitin-mediated regulation and protein complex assembly","description":"The top GO terms center on ubiquitination and ubiquitin-dependent protein catabolic processes, alongside protein oligomerization (homooligomerization, tetramerization). Developmental processes (multicellular organism development, skin development) and cell cycle terms suggest the cluster reflects proteins involved in ubiquitin-regulated protein turnover and assembly of protein complexes that influence development and proliferation. A NOD2 signaling pathway term appears but is less central to the core theme. Overall, the cluster seems best described as ubiquitin-dependent regulation of protein abundance and complex assembly in development and cell cycle control.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0051262","count":4},{"id":"GO:0043588","count":4}]},{"hash":"1552111647030876121","title":"Rho-regulated migration and immune signaling","description":"This cluster is dominated by terms tied to Rho signal transduction and cell movement (myoblast fusion, forebrain migration, vestibular morphogenesis) along with processes in tissue remodeling and development (angiogenesis, cardiac depolarization) and immune regulation (NK cell activity, cytokine/IL-2 production), suggesting a cohesive role in coordinating cytoskeletal dynamics with signaling in development and immune modulation.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":12},{"id":"GO:0007520","count":10},{"id":"GO:0060116","count":9},{"id":"GO:0002859","count":9},{"id":"GO:0002720","count":9}]},{"hash":"1050945045820280925","title":"Cardiovascular development and endothelial differentiation","description":"The top GO terms center on heart and blood vessel formation: Notch signaling in regulation of secondary heart field cardioblast proliferation, cardiac right atrium morphogenesis, venous endothelial cell differentiation, and endothelial cell delamination. While there are some related immune and signaling terms in the mix (GPCR signaling, telomere maintenance, IL-12 regulation, pain detection), the strongest and most cohesive signals point to cardiovascular development and endothelial differentiation, suggesting this is the cluster\u2019s main function, with some annotation noise.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003270","count":6},{"id":"GO:0003213","count":6},{"id":"GO:0060843","count":6},{"id":"GO:0007205","count":6},{"id":"GO:0048549","count":6}]},{"hash":"414286917266975683","title":"Lateral line sensory neuron development and signaling","description":"The top GO terms point to lateral line system development (anterior/posterior), neuronal signaling and plasticity (synaptic plasticity, intracellular signal transduction, response to electrical stimulus), and receptor internalization, suggesting a cluster of proteins involved in sensory neuron development and signal processing in the lateral line system. A minor presence of electron transport-related terms may reflect general cellular energy needs but does not define the cluster's core function.","confidence":"Medium","size":12,"edges":13,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":10},{"id":"GO:0048169","count":10},{"id":"GO:0071257","count":10},{"id":"GO:0048915","count":10},{"id":"GO:0022900","count":10}]},{"hash":"1101319924429993417","title":"ER-Golgi trafficking and barrier formation","description":"The top GO terms are dominated by vesicle transport between the endoplasmic reticulum and Golgi (ER to Golgi and retrograde Golgi-ER transport) and general protein transport, alongside establishment of endothelial barriers and tight junction assembly. This suggests a core theme centered on intracellular trafficking machinery supporting membrane transport and barrier integrity, with a few peripheral terms related to neural development or immune signaling appearing as secondary associations.","confidence":"Medium","size":12,"edges":14,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0035208","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0061028","count":3}]},{"hash":"477090960960361526","title":"Drosophila Oogenesis and Developmental Signaling","description":"This cluster centers on developmental regulation with strong signals for ovarian follicle cell development and somatic stem cell maintenance, plus BMP and Hedgehog signaling (Smoothened), neuroblast proliferation, and transcriptional control, indicating a coordinated developmental module in Drosophila that ties oogenesis to broader tissue differentiation and metabolism.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030730","count":4},{"id":"GO:0030707","count":4},{"id":"GO:0035019","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0010667","count":2}]},{"hash":"958029192462097991","title":"Unknown","description":"The GO terms span disparate functions (osmotic stress response, vacuolar localization, IL-2 production, TGF-\u03b2 signaling, actin remodeling, postsynaptic density assembly, yeast response, and developmental cues) with no clear shared theme, so a single coherent label cannot be confidently assigned.","confidence":"","size":12,"edges":10,"triangles":0,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006970","count":5},{"id":"GO:1903778","count":4},{"id":"GO:1900042","count":4},{"id":"GO:0071560","count":4},{"id":"GO:1904424","count":4}]},{"hash":"1445899989790191568","title":"Proteostasis and Apoptosis Regulation","description":"The top GO terms cluster around cytoplasmic protein quality control by the ubiquitin-proteasome system, positive regulation of proteasomal degradation, and regulation of programmed cell death and apoptosis, pointing to a core theme of maintaining protein homeostasis and controlling cell fate. Additional terms like translation, DNA replication regulation, and nutrient response fit within broader stress/growth control, reinforcing a cohesive theme of cellular quality control and survival under stress.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045740","count":2},{"id":"GO:0071629","count":1},{"id":"GO:0032436","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0006915","count":1}]},{"hash":"100077850520516314","title":"Nucleotide Biosynthesis and Growth Signaling","description":"This cluster shows a concentration of nucleotide biosynthesis terms (CTP and UTP biosynthesis) alongside signaling-related terms (peptidyl-histidine phosphorylation, response to growth hormone, cellular responses to glucose) and various differentiation/regulation terms (neuron projection development, keratinocyte differentiation, leukocyte differentiation). The common thread appears to be metabolic readiness paired with growth and development signaling, even though several terms span different contexts. Therefore, a label reflecting nucleotide metabolism coupled with growth signaling is apt, with a medium level of confidence given the mixed terms.","confidence":"Medium","size":12,"edges":29,"triangles":37,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0018106","count":6},{"id":"GO:0006241","count":6},{"id":"GO:0071333","count":6},{"id":"GO:0061508","count":6},{"id":"GO:0045920","count":6}]},{"hash":"452541110413335210","title":"Neural development and synaptic signaling","description":"The top GO terms point to neural communication and synapse assembly (sensory perception of sound, GABAergic synaptic transmission, presynaptic active zone assembly), combined with neural development processes (oligodendrocyte progenitor proliferation, axon guidance, hair/lineage-related development). This suggests a cluster of proteins involved in nervous system development and synaptic signaling, with emphasis on sensory and axonal connectivity.","confidence":"Medium","size":12,"edges":19,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0071681","count":1},{"id":"GO:0051932","count":1},{"id":"GO:0070445","count":1},{"id":"GO:0060901","count":1}]},{"hash":"785469603270345732","title":"Ubiquitin-Driven Innate Immunity and NF-\u03baB Signaling","description":"The GO terms cluster around innate immune defense and antiviral responses, with a strong emphasis on ubiquitin-related regulation (autoubiquitination, K6-linked ubiquitination) and signaling pathways like NF-\u03baB and TNF, plus modulation of necroptosis and related protein quality control (aggresome assembly). This suggests a coherent theme of ubiquitin-mediated regulation of innate immunity and inflammatory signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":4},{"id":"GO:0042787","count":4},{"id":"GO:0090141","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":3}]},{"hash":"976246348389180778","title":"Embryonic organ morphogenesis","description":"The proteins cluster around diverse embryonic tissue development and morphogenesis processes (lung, eye, brain, neural crest, pancreas, ureteric bud, and digestive tract), along with transcriptional regulation, suggesting a cohesive developmental gene module governing embryogenesis across multiple organs.","confidence":"High","size":12,"edges":43,"triangles":63,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060441","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0021571","count":6},{"id":"GO:0035284","count":6},{"id":"GO:0006366","count":6}]},{"hash":"2030616648590674413","title":"Neuronal synaptic signaling and actin dynamics","description":"The cluster centers on neuronal synapse function and actin cytoskeleton remodeling: neurotransmitter loading into synaptic vesicles, long-term synaptic depression, and neuron projection development suggest synaptic plasticity and growth. The recurring actin-related terms (muscle thin filament assembly, actin cytoskeleton reorganization) and centrosome localization point to cytoskeletal organization, often coordinated during neuronal development. Some transport terms may be less directly connected. Therefore the dominant theme is neuronal synaptic activity with cytoskeletal dynamics.","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071689","count":2},{"id":"GO:0010976","count":2},{"id":"GO:0060292","count":2},{"id":"GO:0051660","count":2},{"id":"GO:2000251","count":2}]},{"hash":"1385797838642032084","title":"Signaling and Cytoskeleton Dynamics","description":"The Top Terms cluster around cellular signaling (B cell receptor signaling; extrinsic apoptotic signaling), endocytosis, calcium signaling, and actin cytoskeleton remodeling (actin cortical patch assembly). Translation and dephosphorylation indicate general regulatory processes, but the connecting theme appears to be broader signaling and structural regulation governing growth and responses to stimuli. Overall, the proteins seem to participate in signaling pathways and cytoskeletal dynamics rather than a single, cohesive pathway.","confidence":"Medium","size":12,"edges":10,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0007283","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0008625","count":2}]},{"hash":"337229814257501080","title":"Developmental signaling and ECM-mediated differentiation","description":"These terms cluster around developmental processes and signaling pathways (multicellular development; Hedgehog/SMO signaling; BMP sequestration in ECM) with a strong emphasis on extracellular matrix interactions (cell-substrate and cell-cell adhesion; hyaluronan biosynthesis) and tissue-specific differentiation (endothelial, mesangial, and inner ear sensory cells). An immune-related term is present but does not override the dominant developmental/ECM theme, supporting a label focused on developmental signaling and ECM-guided tissue formation.","confidence":"Medium","size":12,"edges":19,"triangles":6,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007275","count":11},{"id":"GO:0045880","count":10},{"id":"GO:0035582","count":9},{"id":"GO:0010811","count":9},{"id":"GO:0045602","count":9}]},{"hash":"1949685028192003434","title":"T cell immune signaling and ER protein trafficking","description":"The cluster shows enrichment for T cell cytokine production, T cell apoptotic process, and innate immune response-activating signaling, indicating a shared role in immune signaling. The co-occurring terms for protein transport and protein retention in the ER lumen suggest a link to ER-associated trafficking and processing of secreted immune proteins. A few bacterial biosynthesis terms appear but are likely peripheral noise relative to the dominant immune/ER trafficking theme. ","confidence":"Medium","size":12,"edges":14,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002369","count":2},{"id":"GO:0015031","count":2},{"id":"GO:0006621","count":2},{"id":"GO:0070231","count":2},{"id":"GO:0010204","count":2}]},{"hash":"1588957659272962925","title":"Kidney Morphogenesis and Immune Signaling","description":"The cluster shows a strong emphasis on metanephric tubule development (proximal/distal) and mesonephric duct development, pointing to kidney morphogenesis as the main theme. It also contains several immune-related terms (Fc-gamma receptor signaling, lectin pathway complement activation, NK cell chemotaxis regulation) and other developmental processes, suggesting some immune signaling cross-talk but the kidney development signal is most prominent. ","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":12},{"id":"GO:0038094","count":12},{"id":"GO:0072287","count":12},{"id":"GO:2000502","count":12},{"id":"GO:0071226","count":12}]},{"hash":"939087339407368096","title":"Adrenergic GPCR Signaling and Catecholamine Responses","description":"This cluster centers on adrenergic/catecholamine signaling through GPCR pathways, including MAPK-activating and PLC-activating adrenergic receptor signaling, norepinephrine-epinephrine\u2013mediated vasoconstriction, and dopaminergic synaptic transmission in the brain. The terms point to a cohesive theme of catecholamine signaling influencing neural communication, vascular regulation, and associated signaling cascades, with some immune-modulatory outputs as downstream effects.","confidence":"High","size":12,"edges":60,"triangles":168,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"2183977631729950509","title":"Brain adrenergic-dopaminergic signaling and BP regulation","description":"This cluster centers on neuronal signaling in the brain involving adrenergic and dopaminergic pathways, including dopaminergic synaptic transmission, adrenergic receptor signaling, MAPK activation, and vasoconstriction tied to blood pressure regulation. Terms like brain renin-angiotensin system and norepinephrine-epinephrine\u2013mediated vascular effects reinforce the theme of neural control of cardiovascular function and related synaptic modulation. A few terms related to immune cell differentiation appear as noise; the dominant pattern is brain neurotransmission linked to vascular regulation.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":10},{"id":"GO:0001963","count":10},{"id":"GO:1900453","count":10},{"id":"GO:0001994","count":10},{"id":"GO:0071883","count":10}]},{"hash":"1455000947076049033","title":"Adrenergic and Dopaminergic Neuronal Signaling for Blood Pressure","description":"The top GO terms point to GPCR-mediated signaling with adenylate cyclase activation, MAPK pathways, and dopaminergic synaptic transmission, alongside vascular blood pressure regulation (vasoconstriction and brain renin-angiotensin system). Electron transport chain appears as a secondary, non-core signal, but the dominant theme ties neuronal adrenergic/dopaminergic signaling to blood pressure control.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0045777","count":10},{"id":"GO:0007190","count":9},{"id":"GO:0002035","count":7}]},{"hash":"690668353744815107","title":"Immune signaling and cytoskeletal dynamics","description":"This cluster is enriched for immune signaling terms (B cell receptor signaling, T cell receptor signaling, innate immune response) and cytoskeletal/membrane trafficking processes (actin filament bundle assembly, caveolin-mediated endocytosis, cell migration), suggesting a theme of signaling-driven cytoskeletal remodeling and movement in immune contexts. The insulin receptor pathway term can reflect metabolic signaling cross-talk but does not override the dominant immune/cytoskeletal pattern.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0048011","count":3}]},{"hash":"957052005589174999","title":"Cardiometabolic Signaling and Development","description":"The top GO terms cluster around signaling pathways (PKC signaling, Rap signaling, integrin activation) and development/differentiation processes (heart development, fat cell differentiation, catecholamine secretion), suggesting a theme of signaling networks linked to cardiometabolic tissues. Some terms like ribosome biogenesis are more general, but the dominant pattern supports this label. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0033625","count":1},{"id":"GO:0010925","count":1},{"id":"GO:0070528","count":1}]},{"hash":"522717624857374085","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048814","count":2},{"id":"GO:0030717","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0051567","count":2},{"id":"GO:0000398","count":2}]},{"hash":"1908284628325366114","title":"Immune Signaling Regulators","description":"The top GO terms cluster around regulation of immune pathways, notably positive regulation of TLR3 signaling, regulation of MAPK/ERK cascades, and modulation of T cell receptor and interferon signaling, indicating these proteins primarily modulate immune signaling rather than a single structural process; a few terms touch on neural or stress-related processes but do not override the immune-focused theme.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0034141","count":10},{"id":"GO:0000200","count":9},{"id":"GO:0070373","count":9},{"id":"GO:0050860","count":9},{"id":"GO:0060116","count":8}]},{"hash":"34774721309202373","title":"Vertebrate organogenesis and neural development","description":"The GO terms cluster around developmental and morphogenetic processes across multiple tissues, including heart left/right asymmetry, skeletal morphogenesis, uterus morphogenesis, and metencephalon development, with a neural component indicated by motor neuron axon fasciculation. Additional terms on mRNA processing and transcription elongation regulation suggest gene-expression control during development. This points to a cohesive theme of vertebrate organogenesis and neural patterning.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051096","count":2},{"id":"GO:0061371","count":2},{"id":"GO:0048705","count":2},{"id":"GO:0097156","count":2},{"id":"GO:0000398","count":1}]},{"hash":"942459044048443619","title":"Dopaminergic and Adrenergic Synaptic Signaling","description":"The cluster shows strong representation of dopaminergic synaptic transmission, adrenergic receptor signaling, and morphine response, with related terms about norepinephrine-epinephrine\u2013driven vasoconstriction and MAPK-activating adrenergic signaling, pointing to catecholaminergic neurotransmission in CNS and peripheral adrenergic pathways. Some terms (thymocyte differentiation and obsolete NAD(P)H oxidase regulation) are less connected, but the dominant theme remains catecholamine signaling and dopaminergic transmission.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043278","count":12},{"id":"GO:0002035","count":11},{"id":"GO:0001963","count":11},{"id":"GO:1900453","count":11},{"id":"GO:0001994","count":11}]},{"hash":"1774950081857886754","title":"Brain Adrenergic and Dopaminergic GPCR Signaling","description":"The top GO terms point to neural signaling mediated by GPCRs, especially adrenergic and dopaminergic pathways, including dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK and PLC pathways), and systemic blood pressure regulation via norepinephrine/epinephrine. While a few terms touch immune processes, the dominant theme is brain-based GPCR signaling involved in neuromodulation and vascular regulation, centering on adrenergic and dopaminergic activity.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"1070081275975709147","title":"Brain adrenergic and dopaminergic signaling","description":"The top GO terms cluster around brain-specific catecholaminergic signaling: adrenergic receptor pathways (MAPK-activating and PLC-activating), dopaminergic synaptic transmission, and associated vascular regulation (norepinephrine/epinephrine\u2013mediated vasoconstriction and brain renin-angiotensin implications). While a few terms touch on immune differentiation, the dominant pattern is neural adrenergic/dopaminergic signaling tied to brain function and blood pressure control.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"1730552704555656674","title":"Adrenergic GPCR Signaling and Blood Pressure Regulation","description":"The top GO terms point to adrenergic GPCR signaling that activates adenylate cyclase, including MAPK-activating adrenergic receptor pathways, and to physiological processes governing vascular tone and blood pressure (norepinephrine/epinephrine vasoconstriction, brain RAAS, positive regulation of blood pressure). Dopaminergic synaptic transmission also supports a neuromodulatory brain context. Although energy metabolism (electron transport chain) appears, the dominant theme is neuromodulatory signaling linked to autonomic regulation of blood pressure, justifying this label.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":12},{"id":"GO:0022900","count":12},{"id":"GO:0007190","count":12},{"id":"GO:0035025","count":12},{"id":"GO:0045777","count":12}]},{"hash":"1386673044745321657","title":"Transmembrane Transport and Osmoregulation","description":"The top GO terms are dominated by various membrane transport activities (GABA, ammonium, carnitine, polyamine, amino acid transport) and related osmoregulatory processes (cell volume homeostasis, hypotonic response), suggesting a cluster centered on transmembrane transport and ionic/osmotic balance. Some terms appear tangential or obsolete, but the shared theme of membrane transport defines the core function.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0015812","count":3},{"id":"GO:0035826","count":3},{"id":"GO:0006884","count":3},{"id":"GO:0070634","count":3},{"id":"GO:0098713","count":3}]},{"hash":"1388589467289809850","title":"Organ Development Across Tissues","description":"This cluster\u2019s top GO terms are dominated by tissue- and organ-specific development (male gonad, skin, inner ear morphogenesis, collecting duct development, ductus arteriosus closure), suggesting a general theme of organogenesis across multiple tissues. A few other terms (RNA methylation, GTPase regulation) are more general/background signals, but the developmental signals prevail.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008584","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0051092","count":2},{"id":"GO:0046597","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1775756020774102527","title":"Small GTPase Signaling and Morphogenesis","description":"The cluster is dominated by GO terms linking Ras-family GTPase signaling (Rap, Rac, Ral) with pathways like nerve growth factor signaling and processes affecting cell morphology (cell junction assembly, microvillus assembly, dendrite morphogenesis). This suggests a shared theme of GTPase-driven signaling regulating cytoskeletal dynamics and morphogenesis, rather than a single narrow pathway. Some terms (immune signaling, cardiac apoptotic regulation) are less central but do not override the core GTPase-morphogenesis pattern.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902715","count":2},{"id":"GO:1901888","count":2},{"id":"GO:0032486","count":2},{"id":"GO:0038180","count":2},{"id":"GO:0035022","count":2}]},{"hash":"2095664374471265315","title":"Exocytosis and vesicle trafficking","description":"The cluster\u2019s top GO terms cluster around vesicle fusion and secretion: exocytosis, peptide hormone secretion, exocyst localization, and negative regulation of SNARE complex assembly, all pointing to trafficking of vesicles to membranes and fusion events. Rhabdomere membrane biogenesis also ties to membrane formation relevant to trafficking processes. A few terms (antibiotic biosynthetic and poly-hydroxybutyrate biosynthetic processes) seem less related and may be noise, but the dominant theme is exocytosis and membrane trafficking. Confidence: Medium","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006887","count":3},{"id":"GO:0030072","count":2},{"id":"GO:0045313","count":2},{"id":"GO:0035544","count":2},{"id":"GO:0051601","count":2}]},{"hash":"1262872322419834232","title":"Brain Adrenergic and Dopaminergic Signaling","description":"Most GO terms point to signaling in the brain involving adrenergic and dopaminergic transmission, including MAPK-activating adrenergic receptor signaling, phospholipase C\u2013activating adrenergic pathways, dopaminergic synaptic transmission, and norepinephrine-epinephrine\u2013mediated vasoconstriction affecting blood pressure. A few terms relate to immune cell differentiation and neutrophil chemotaxis, which appear as outliers or annotation noise relative to the core neuronal signaling theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":12},{"id":"GO:0001963","count":12},{"id":"GO:1900453","count":12},{"id":"GO:0001994","count":12},{"id":"GO:0071883","count":12}]},{"hash":"1092643403902729717","title":"Chemosensory perception and dopaminergic signaling","description":"Top terms cluster around chemosensory detection (pheromone, chemical stimulus, taste) and dopaminergic synaptic transmission, suggesting a group of proteins involved in chemical sensing and neural signaling. Some annotations touch on neuroendocrine and vascular regulation, but the dominant theme is chemosensory perception linked to brain neurotransmission. Therefore the label captures the main idea with moderate confidence.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":8},{"id":"GO:0007606","count":8},{"id":"GO:0050909","count":5},{"id":"GO:0001580","count":5},{"id":"GO:0090023","count":3}]},{"hash":"607611332983492766","title":"Cardiac apoptosis and action potential regulation","description":"This cluster is best described by the convergence of apoptotic processes (apoptotic process, extrinsic apoptotic signaling) and cardiac electrical activity terms (ventricular cardiac muscle cell action potential, positive regulation of membrane depolarization during cardiac muscle cell action potential), suggesting a theme of cardiac cell survival intertwined with electrical signaling. A mitochondrial assembly term and TOR signaling note a broader regulatory context, but the strongest signal centers on apoptosis and cardiac electrophysiology.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":1},{"id":"GO:0010738","count":1},{"id":"GO:1902261","count":1},{"id":"GO:0006915","count":1},{"id":"GO:1900827","count":1}]},{"hash":"1118426954789222962","title":"Intrinsic apoptosis and cellular stress response","description":"Top GO terms cluster around intrinsic apoptotic signaling (p53-mediated), regulation of mitochondrial outer membrane permeabilization, and cellular stress responses (temperature stimulus, inflammatory response), suggesting a theme of stress-induced apoptosis; although a couple of terms relate to gonad development or muscle differentiation, the dominant pattern points to apoptosis and stress signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071502","count":1},{"id":"GO:0048147","count":1},{"id":"GO:0008584","count":1},{"id":"GO:0035914","count":1},{"id":"GO:0002526","count":1}]},{"hash":"592390392109222574","title":"Rac/Cdc42-Driven Actin Remodeling and Motility","description":"This cluster is dominated by GO terms for Rac and Cdc42 signaling, and positive regulation of actin polymerization, lamellipodium and pseudopodium assembly, which together point to actin cytoskeleton remodeling and cell motility. Ubiquitination can regulate actin-regulatory proteins, reinforcing the theme. Some RNA processing terms appear, but the strongest signal centers on cytoskeletal dynamics and signaling related to movement.","confidence":"High","size":11,"edges":49,"triangles":117,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0016567","count":6},{"id":"GO:0030838","count":5},{"id":"GO:0010592","count":5},{"id":"GO:0016601","count":5},{"id":"GO:0032488","count":5}]},{"hash":"651183592138218349","title":"Chromatin Regulation and Cell Cycle Transcription","description":"Most terms relate to chromatin state and transcription control during the cell cycle (heterochromatin formation, nucleosome density, histone deacetylation, G1/S and G2/M regulation). This points to a functional cluster centered on chromatin remodeling and cell-cycle\u2013linked transcription. A few outliers involve muscle development or plant defense, likely due to broad annotation, but the central theme remains chromatin regulation.","confidence":"Medium","size":11,"edges":51,"triangles":132,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000083","count":10},{"id":"GO:0006346","count":10},{"id":"GO:0070845","count":10},{"id":"GO:1901300","count":10},{"id":"GO:0048742","count":10}]},{"hash":"143206827077605185","title":"Innate and adaptive immune signaling","description":"The dominant GO terms point to immune system activity: type II interferon production, innate immune response, ERK cascade regulation, NK cell and B cell activation regulation, and host\u2011mediated suppression of symbiont invasion. A lens morphogenesis term appears as an outlier, likely annotation noise, but overall the cluster centers on immune signaling and lymphocyte regulation, spanning both innate and adaptive immunity.","confidence":"Medium","size":11,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0072643","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0002089","count":3},{"id":"GO:0010765","count":3},{"id":"GO:0061000","count":3}]},{"hash":"1853453648422933616","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0035640","count":7},{"id":"GO:0001666","count":7},{"id":"GO:0034476","count":6},{"id":"GO:1903608","count":6},{"id":"GO:0006306","count":6}]},{"hash":"2280250969248974386","title":"Cell cycle control and DNA repair with developmental signaling","description":"The cluster\u2019s top GO terms cluster around cell cycle regulation (G1/S transition, intra-S checkpoint) and DNA repair (meiotic recombination, trinucleotide repeat maintenance), suggesting a core role in genome stability and mitotic control. Additional terms highlight signaling pathways (calcineurin-NFAT, glucocorticoid signaling) and developmental processes (neuron differentiation, vascular branching, cardiac hypertrophy), implying these proteins link cell cycle control to development and stress-response signaling. An outlier term (lipid A biosynthesis) may reflect annotation noise rather than a true functional theme.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000082","count":11},{"id":"GO:0014898","count":11},{"id":"GO:0009245","count":11},{"id":"GO:0031573","count":11},{"id":"GO:0051531","count":11}]},{"hash":"1522756414308444410","title":"Adrenergic GPCR signaling and BP regulation","description":"This cluster is dominated by GO terms tied to adrenergic receptor signaling, cAMP activation, and norepinephrine-epinephrine\u2013mediated vasoconstriction that regulate systemic blood pressure, along with dopaminergic synaptic transmission and brain renin-angiotensin system activity. A mitochondria-related term (electron transport chain) is present but does not define the core theme; the shared function appears to be GPCR-mediated signaling influencing cardiovascular and neural processes.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":10},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0007190","count":10},{"id":"GO:0045777","count":10}]},{"hash":"1782041744922392489","title":"Iron-Sulfur Biogenesis and DNA Replication","description":"Among the top terms, iron-sulfur cluster assembly and DNA replication are prominent, suggesting proteins involved in Fe-S maturation that support genome maintenance. Other terms point to broader protein maturation and stress-response processes (post-translational targeting to membranes, chaperone-related refolding, responses to heat and oxidative stress), which fit with a cluster of proteins functioning in genome integrity and cellular quality control under stress. Some terms are obsolete or species-specific, but the core theme centers on Fe-S biology linked to replication and stress management.","confidence":"Medium","size":11,"edges":31,"triangles":48,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031204","count":6},{"id":"GO:0016226","count":6},{"id":"GO:0006880","count":6},{"id":"GO:1902037","count":6},{"id":"GO:0000742","count":6}]},{"hash":"407459995007513913","title":"Mitotic spindle assembly and microtubule dynamics","description":"The top GO terms are dominated by mitotic spindle processes and microtubule dynamics, including plus- and minus-end-directed microtubule sliding, spindle assembly, centrosome separation, and spindle elongation, as well as maintenance of microtubule cytoskeleton polarity. A tissue-specific term (cerebellar granular layer organization) is present but the overarching theme is spindle/microtubule function, suggesting a cohesive role in mitosis and cytoskeletal organization.","confidence":"High","size":11,"edges":38,"triangles":85,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0070462","count":11},{"id":"GO:0021685","count":11},{"id":"GO:0031535","count":11},{"id":"GO:0099607","count":11},{"id":"GO:0000022","count":11}]},{"hash":"330651318941110721","title":"Embryonic development and organ morphogenesis","description":"This cluster aggregates GO terms focused on embryonic tissue formation and organogenesis across multiple systems (palatal development, mesoderm, placenta, hair follicles, pancreas, endocrine system, etc.), plus patterning and EMT events, indicating a broad developmental/morphogenetic program rather than a single pathway.","confidence":"High","size":11,"edges":12,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":11},{"id":"GO:0000122","count":8},{"id":"GO:0060972","count":7},{"id":"GO:0007498","count":7},{"id":"GO:0060806","count":7}]},{"hash":"2034445528916377889","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000480","count":6},{"id":"GO:0000472","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0000209","count":5},{"id":"GO:0016575","count":5}]},{"hash":"985720047606407311","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":33,"triangles":28,"max_degree":9,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0051973","count":5},{"id":"GO:0016311","count":5},{"id":"GO:0098506","count":5},{"id":"GO:0098504","count":5},{"id":"GO:1904355","count":5}]},{"hash":"1096995119539522179","title":"Bud neck\u2013localized mitosis and septin ring assembly","description":"These proteins are enriched for mitotic and cytokinesis functions, especially septin ring assembly and localization to the bud neck in budding yeast, with supporting terms for cell polarity and protein heterooligomerization, indicating a coherent role in bud neck\u2013associated cell division.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0010458","count":4},{"id":"GO:0097271","count":4},{"id":"GO:0000281","count":4}]},{"hash":"435688449301147562","title":"Neuronal development and signaling","description":"The cluster is enriched for terms related to neural development and signaling, including dendrite morphogenesis, sensory perception of pain, and Rho-mediated signaling, as well as ion transport that supports neuronal activity. While there is an outlier term related to immune defense, the dominant pattern across the top GO terms points to neuronal development and the signaling/cytoskeletal processes that shape it.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":9},{"id":"GO:0007275","count":7},{"id":"GO:0048813","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0046827","count":7}]},{"hash":"56367684527646210","title":"Retinoid metabolism and inner ear development","description":"The top GO terms cluster around retinol/retinal metabolic processes and inner ear morphogenesis, with supporting signals for balance, neural tube development, and broader embryonic development. This suggests a shared role for retinoid signaling in ear and neural development, making this label representative of the cluster.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":11},{"id":"GO:0042574","count":11},{"id":"GO:0015976","count":10},{"id":"GO:0042472","count":10},{"id":"GO:0032180","count":10}]},{"hash":"760203371016682856","title":"Unknown","description":"The GO terms are highly diverse, spanning vertebrate development (angiogenesis and neural crest\u2013driven heart development), cell-cycle signaling (spindle assembly, MAPKK activity), immune/stress responses (dsRNA and muramyl dipeptide), and biofilm formation, which together do not point to a single coherent function for the cluster.","confidence":"","size":11,"edges":28,"triangles":31,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":10},{"id":"GO:0090606","count":10},{"id":"GO:0000186","count":10},{"id":"GO:0061308","count":10},{"id":"GO:0001525","count":10}]},{"hash":"1732677647092150104","title":"Axon guidance and synapse formation","description":"Proteins in this cluster are enriched for neural development and synaptic organization terms, including axon guidance, nervous system development, synapse assembly, and synapse organization, which together point to neural connectivity and synaptogenesis. Immune-related terms are present but appear less central to the main theme. This supports a cohesive interpretation as a neural wiring/synapse-forming cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007411","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0051965","count":3},{"id":"GO:0002859","count":3},{"id":"GO:0002720","count":3}]},{"hash":"1788413015852820703","title":"Complement Regulation and Adhesive Signaling","description":"This cluster is dominated by GO terms for complement activation across lectin and classical pathways, along with negative regulation of complement activation, indicating a core immune-regulatory theme. The presence of cell adhesion terms (heterophilic and cell-matrix adhesion) and regulation of integrin activation, as well as PKC signaling modulation, suggests a broader link between immune regulation and adhesion signaling. An outlier term for thyroid hormone generation is present but does not outweigh the central theme.","confidence":"High","size":11,"edges":8,"triangles":2,"max_degree":5,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0001867","count":11},{"id":"GO:0006958","count":10},{"id":"GO:0007597","count":10},{"id":"GO:0007157","count":10},{"id":"GO:0006590","count":10}]},{"hash":"766825886224891951","title":"Synapse Organization and Signaling","description":"This cluster centers on terms tied to synaptic localization, dendritic spine morphogenesis, and actin-based cytoskeleton organization, plus receptor clustering and various receptor-mediated signaling pathways (neurotrophin/TRK, BCR, TCR). Together, these point to a module governing synapse structure and signal transduction, with Rho signaling integrating cytoskeletal dynamics. The presence of immune receptor terms likely reflects shared signaling components rather than a separate pathway, so the core theme remains neuronal synapse organization and signaling.","confidence":"Medium","size":11,"edges":18,"triangles":2,"max_degree":6,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0035418","count":8},{"id":"GO:0008285","count":8},{"id":"GO:0007266","count":8},{"id":"GO:0060997","count":8},{"id":"GO:0043113","count":8}]},{"hash":"569052598536048818","title":"Lipid homeostasis and insulin\u2013glucose signaling","description":"The top GO terms point to lipid management (phospholipid homeostasis; phosphatidylcholine biosynthesis regulation) and energy signaling (insulin receptor signaling and glucose transport), suggesting a core theme around lipid metabolism coupled with glucose signaling. Additional terms such as small GTPase signaling and stress responses (ethanol, xenobiotic) indicate broader signaling integration and cellular adaptation, but the central thread appears to be lipid metabolism linked to energy sensing. ","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055091","count":4},{"id":"GO:0010628","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0015758","count":4},{"id":"GO:0045471","count":4}]},{"hash":"1722649600390500743","title":"Neural development and regeneration","description":"This cluster centers on nervous system development and neural remodeling (collateral sprouting), with supporting developmental terms such as embryonic forelimb morphogenesis, suggesting a shared role in neural growth and patterning. A few immune-related terms appear but do not define the main theme, which is neural development/repair.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0019731","count":3},{"id":"GO:0035584","count":3},{"id":"GO:0050829","count":3},{"id":"GO:0050830","count":3}]},{"hash":"1759137449144474034","title":"Mitosis and cell cycle regulation in mammary epithelium","description":"The cluster is dominated by mitotic cell cycle terms (G1/S and G2/M transitions, re-entry into mitosis, spindle pole separation) indicating a cohesive focus on mitotic progression. Transcription-related terms (DNA-templated transcription, regulation of RNA Pol II) suggest coordinated transcriptional control during this cell cycle. The mammary gland epithelial proliferation term hints at tissue context but does not override the core mitotic/regulatory theme.","confidence":"High","size":11,"edges":40,"triangles":73,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000082","count":8},{"id":"GO:0033598","count":8},{"id":"GO:0000320","count":8},{"id":"GO:0000086","count":8},{"id":"GO:0000122","count":8}]},{"hash":"1842148256069639573","title":"Auditory neural signaling and CNS development","description":"The terms cluster around nerve impulse transmission, central nervous system development, and synapse organization, with an additional auditory sensory-detection reference. While immune regulation and angiogenesis terms appear, the dominant theme is nervous system signaling and sensory processing, especially related to hearing.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0019226","count":3},{"id":"GO:0007417","count":2},{"id":"GO:0002859","count":2},{"id":"GO:0002720","count":2},{"id":"GO:0050871","count":2}]},{"hash":"363826469418840846","title":"RNA Processing and Splicing Regulation","description":"The proteins are enriched for mRNA processing and splicing terms (splice site recognition, spliceosome activity, processing), plus mRNA export, stabilization, poly(A) tail regulation, translation initiation, and RNA silencing by miRNAs and regulatory ncRNAs, indicating a cohesive role in mRNA maturation and post-transcriptional control.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0006406","count":3},{"id":"GO:0048255","count":3}]},{"hash":"1813926109169586352","title":"Cell adhesion and nervous system development","description":"This cluster is dominated by GO terms for heterophilic cell-cell adhesion, regulation of actin cytoskeleton organization by adhesion, and regulation of synapse assembly, along with nervous system development. While there are some immune regulation and host interaction terms present, the core signal ties to adhesion-driven neural connectivity and synapse formation (including AV node/His bundle adhesion contexts). ","confidence":"High","size":11,"edges":24,"triangles":11,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0002859","count":8},{"id":"GO:0090138","count":8},{"id":"GO:0086072","count":8},{"id":"GO:0043031","count":8}]},{"hash":"2119039424549302626","title":"Neuronal synaptic trafficking and spine morphogenesis","description":"The top GO terms cluster around synaptic function: regulation of synaptic vesicle exocytosis, excitatory postsynaptic potential, and dendritic spine morphogenesis, complemented by mitochondrial distribution in neurons and neuron survival. Golgi-to-plasma membrane transport also supports membrane trafficking relevant to synaptic vesicle cycling, making the neuronal synapse/trafficking theme the best unifying label, despite a few generic terms. ","confidence":"High","size":11,"edges":13,"triangles":1,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0043001","count":2},{"id":"GO:0061001","count":2},{"id":"GO:1903206","count":2},{"id":"GO:0048312","count":2}]},{"hash":"1496672710841717312","title":"Ubiquitin-Proteasome Degradation","description":"This cluster is heavily enriched for ubiquitin-dependent protein catabolism, including SCF-dependent proteasomal degradation and autoubiquitination, pointing to a core role in the ubiquitin-proteasome system and targeted protein turnover. Additional terms touching peroxisomal protein import and cell cycle/stress signaling can be linked to how ubiquitination regulates protein levels during cycle progression and stress responses, supporting a cohesive theme around protein quality control and regulation via ubiquitin-mediated degradation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0031146","count":5},{"id":"GO:0016558","count":5},{"id":"GO:0051865","count":4},{"id":"GO:0000083","count":3}]},{"hash":"1096157007429094494","title":"Exocytosis and vesicle trafficking","description":"This cluster centers on regulated exocytosis and secretory vesicle processes across cell types: synaptic vesicle fusion and neurotransmitter release, cytotoxic granule release, eosinophil degranulation, acrosome reaction, intra-Golgi vesicle transport, and related secretory pathways like cornified envelope assembly. The shared theme is vesicle-mediated secretion and trafficking in diverse contexts.","confidence":"High","size":11,"edges":21,"triangles":14,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2000463","count":5},{"id":"GO:0001916","count":4},{"id":"GO:0010811","count":4},{"id":"GO:0007340","count":4},{"id":"GO:0043311","count":4}]},{"hash":"255027941576536262","title":"Vesicle trafficking and exocytosis","description":"The top GO terms point to secretory and vesicle trafficking processes: exocytosis and vesicle fusion (synaptic vesicle fusion, acrosome reaction, spontaneous neurotransmitter secretion, intra-Golgi vesicle transport), secretory-related skin formation (cornified envelope assembly), and related regulation of adhesion and immune cell degranulation. This suggests a cohesive theme of regulated vesicle trafficking and membrane fusion across diverse cellular contexts.","confidence":"High","size":11,"edges":11,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001916","count":2},{"id":"GO:0010811","count":2},{"id":"GO:0007340","count":2},{"id":"GO:0043311","count":2},{"id":"GO:2000463","count":2}]},{"hash":"852891589327280494","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000447","count":2}]},{"hash":"1875333355400115946","title":"Innate Immunity and Cardiac Signaling","description":"This cluster is dominated by innate immune response terms (GO:0045087) and several cardiac muscle-related processes (muscle contraction, Purkinje to ventricular signaling, cellular response to TGF-beta), suggesting a theme of immune signaling interacting with cardiomyocyte signaling. A few terms (e.g., uterus development, stress granule localization, ubiquitin-related pathways) appear as outliers, but the core signal ties immunity to cardiac muscle signaling.","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0010667","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0006936","count":3},{"id":"GO:0060065","count":3}]},{"hash":"2147294108922393815","title":"Auditory transduction and inner-ear signaling","description":"The cluster includes terms for sensory perception of sound, inner ear development, chemical synaptic transmission, and excitatory postsynaptic potentials, plus Na+/K+ ion transport and membrane depolarization, pointing to proteins involved in converting acoustic signals into neural activity and transmitting them across synapses in the auditory pathway, with supporting general neuronal signaling components.","confidence":"High","size":11,"edges":38,"triangles":53,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":7},{"id":"GO:0007626","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0035725","count":6}]},{"hash":"1373007336522267887","title":"Kidney development and morphogenesis","description":"This cluster is dominated by GO terms for mesonephric duct development and metanephric tubule morphogenesis, indicating involvement in kidney organogenesis; additional terms touch on related developmental processes (cartilage condensation, vascular morphogenesis) and some immune signaling, but the kidney development terms are the strongest signal.","confidence":"High","size":11,"edges":42,"triangles":94,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":11},{"id":"GO:0038094","count":11},{"id":"GO:0072287","count":11},{"id":"GO:2000502","count":11},{"id":"GO:0071226","count":11}]},{"hash":"598036487394622706","title":"Adaptive Immune Activation and Cytokine Production","description":"This cluster centers on adaptive immunity and cytokine signaling. Recurrent terms include positive regulation of T cell proliferation, adaptive immune response, positive regulation of B cell activation, cytokine production, and interleukin-2 production, indicating activation and communication among immune cells. A few terms related to innate sensing (peptidoglycan detection) and other non-immune processes are present, but the dominant pattern points to immune activation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":3},{"id":"GO:0002250","count":3},{"id":"GO:0002859","count":2},{"id":"GO:0050871","count":2},{"id":"GO:1900042","count":2}]},{"hash":"85853288474544002","title":"Lipid metabolism and chemical stress responses","description":"The top GO terms point to lipid-related processes (fatty acid biosynthesis, prostaglandin and retinol metabolism) as core functions, with additional signals of chemical and immune stress (ethanol oxidation/catabolism, response to copper ion, response to lipopolysaccharide) and xenobiotic/drug response (antineoplastic agent). The mix suggests a broad but coherent cluster centered on lipid metabolism together with general chemical stress/immune responses rather than a single precise pathway.","confidence":"Medium","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006069","count":7},{"id":"GO:0042572","count":7},{"id":"GO:0006068","count":7},{"id":"GO:0006633","count":6},{"id":"GO:0097327","count":5}]},{"hash":"245190882170019267","title":"Ubiquitin-Driven Chromatin Regulation and Cell Cycle","description":"The Top Terms cluster around ubiquitination-related processes (ubiquitin-dependent ERAD pathway, histone monoubiquitination, protein autoubiquitination) and chromatin organization, plus cell cycle/meiosis terms (mitotic cell cycle, cell division, synaptonemal complex organization). This suggests the proteins operate in ubiquitin-mediated regulation of chromatin and chromosome dynamics during cell division, with additional pleiotropic roles in immune signaling and neuronal development observed in GO annotations.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030433","count":11},{"id":"GO:0031497","count":11},{"id":"GO:0000278","count":11},{"id":"GO:0051865","count":11},{"id":"GO:0010390","count":11}]},{"hash":"1267314777110433289","title":"Unknown","description":"The top GO terms span transcriptional regulation, several developmental processes (midbrain development, amelogenesis), extracellular matrix remodeling (elastin catabolic process), and various immune-related activities (response to yeast, neutrophil-mediated killing, cytokine production regulation). There isn\u2019t a single coherent function that unifies these terms, suggesting a heterogeneous set of roles among the proteins rather than a distinct, shared pathway.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":8},{"id":"GO:0030901","count":8},{"id":"GO:0097186","count":6},{"id":"GO:0060309","count":6},{"id":"GO:0001878","count":6}]},{"hash":"568037359471845194","title":"Cardiac conduction and heart development","description":"Two of the top GO terms point directly to cardiac function: electrical coupling in cardiac conduction and heart trabecula formation, suggesting the cluster centers on heart development and signaling. Other terms (nitrite and glucose transport, protein folding, sumoylation, amyloid formation, T cell proliferation, cell division) reflect broader cellular processes and protein quality control, which may accompany heart-related proteins but are less defining. Overall, the cardiac-related terms provide a coherent theme for this cluster.","confidence":"Medium","size":11,"edges":12,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015707","count":3},{"id":"GO:1904659","count":3},{"id":"GO:0086064","count":2},{"id":"GO:0033197","count":2},{"id":"GO:0022417","count":2}]},{"hash":"77344017916417145","title":"Developmental transcriptional regulators","description":"Top GO terms reveal transcriptional regulation by RNA Pol II alongside diverse developmental processes (palate, mesoderm, placenta, hair follicles, pancreas, left-right patterning). This points to a cluster of transcriptional regulators governing embryonic development and organogenesis.","confidence":"Medium","size":11,"edges":15,"triangles":0,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":11},{"id":"GO:0000122","count":10},{"id":"GO:0006366","count":7},{"id":"GO:0060972","count":6},{"id":"GO:0007498","count":6}]},{"hash":"233720651712644276","title":"Steroid Hormone and Prostaglandin Metabolism","description":"The cluster is dominated by GO terms for prostaglandin biosynthesis and multiple steroid hormone metabolisms (androgen, progesterone, aldosterone), with supporting involvement of omega-hydroxylase P450 pathways. This points to a core theme of lipid-based signaling molecule production and steroid metabolism, even if a few other terms are peripheral. ","confidence":"High","size":11,"edges":14,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":3},{"id":"GO:0097267","count":3},{"id":"GO:0033076","count":3},{"id":"GO:0008585","count":3},{"id":"GO:0035902","count":3}]},{"hash":"77875866741547828","title":"Ubiquitin-Proteasome Degradation and Metal Stress Response","description":"The cluster shows strong enrichment for ubiquitin-dependent protein catabolic processes, including SCF-dependent proteasomal degradation and protein polyubiquitination, indicating proteasome-mediated turnover as a core function. It also includes terms related to circadian rhythm regulation and responses to metals/oxidative stress (methylmercury, arsenic, cadmium), suggesting a role in stress-modulated protein turnover and possibly circadian control. While there are no interactions shown, the GO profile points to a proteostasis-and-stress-response theme.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0031146","count":7},{"id":"GO:0000209","count":6},{"id":"GO:0042752","count":6},{"id":"GO:0071406","count":5}]},{"hash":"1835416422721138164","title":"Isoprenoid and terpenoid biosynthesis","description":"The top GO terms point to biosynthesis of terpenoids and isoprenoids (monoterpenes, FPP, GPP, GGPP) and related cholesterol/quinone pathways, suggesting a common theme of lipid/isoprenoid biosynthesis. Transport-related terms appear less central to the core pattern, but do not override the strong terpenoid/isoprenoid signal.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1901663","count":4},{"id":"GO:0015031","count":4},{"id":"GO:0006695","count":4},{"id":"GO:0043693","count":4},{"id":"GO:0045337","count":4}]},{"hash":"665283750698698683","title":"Unknown","description":"The top GO terms span divergent processes (keratinization, apoptosis, DNA recombination, xenobiotic response, cell cycle regulation, hormone/cAMP signaling, renal water transport, glycogen metabolism, and more), showing no single coherent functional theme. This heterogeneity suggests the proteins do not share a unified biological role that can be succinctly named, so the cluster should be labeled Unknown.","confidence":"","size":11,"edges":13,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0080111","count":2},{"id":"GO:2001153","count":2},{"id":"GO:1900087","count":2}]},{"hash":"29418930327336751","title":"Neural and sensory organ development","description":"The top GO terms cluster around development of neural structures and sensory organs (metencephalon, dorsal spinal cord, globus pallidus, olfactory placode, inner ear, amacrine cell differentiation) as well as related craniofacial development (roof of mouth). This suggests proteins functioning in neural and sensory organ formation, justifying the label.","confidence":"High","size":11,"edges":19,"triangles":2,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":8},{"id":"GO:0030910","count":8},{"id":"GO:0021759","count":8},{"id":"GO:0048839","count":8},{"id":"GO:0021516","count":8}]},{"hash":"111244321513291305","title":"Placental development with ECM remodeling and coagulation","description":"The cluster is dominated by placental/embryonic development terms, especially trophoblast giant cell differentiation and placenta development, plus left-right patterning. Collagen catabolic process points to extracellular matrix remodeling, while blood coagulation and complement activation reflect hemostatic and immune processes tied to placentation. Endocrine system and pancreatic cell development terms suggest broader developmental programs linked to placental biology. Overall, the proteins appear tied to placental development with matrix remodeling and coagulation/immune activity.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0030574","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1797627231703767403","title":"Unknown","description":"The top GO terms cover a wide range of processes across different tissues (bone development, gonad development, pigmentation, B cell differentiation/signaling, PKC signaling regulation, myelination, neuronal plasticity, transcytosis) with no clear single pathway or functional theme binding them together. Because there is no cohesive, interpretable common function or interaction pattern (no edges or connectivity), this cluster cannot be confidently labeled with a specific biological process.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001649","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0035208","count":1},{"id":"GO:0002337","count":1}]},{"hash":"858372277302518766","title":"Neural development and synaptic signaling","description":"Primarily driven by nervous system development, synapse assembly/transmission (including GABAergic signaling), and sensory perception of sound, with supporting terms for neural cell adhesion and oligodendrocyte progenitor regulation. The dominant GO terms suggest a cohesive theme around neural development and synaptic communication; bone ossification appears incidental rather than core to the cluster.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0043931","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0007157","count":7},{"id":"GO:0007156","count":6},{"id":"GO:0051965","count":6}]},{"hash":"513486626534936883","title":"Membrane Transporters and Mitochondrial Import","description":"The top GO terms cluster around transmembrane transport of small molecules (glucose, pantothenate, inositol, biotin) and proteins destined for the mitochondrial inner membrane, suggesting a theme of membrane transport paired with mitochondrial trafficking.","confidence":"High","size":11,"edges":15,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":3},{"id":"GO:0045039","count":2},{"id":"GO:0072321","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0015887","count":2}]},{"hash":"1892804645226890556","title":"Mitochondrial Apoptotic Regulation","description":"The top GO terms point to mitochondrial processes linked to apoptosis, such as maintaining mitochondrial polarization, inhibiting extrinsic apoptotic signaling, and release of cytochrome c. Also includes mitochondrial protein import, supporting a mitochondrial-centric function; a few terms are incidental. This supports a cohesive theme of mitochondrial apoptotic control.","confidence":"High","size":11,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051902","count":5},{"id":"GO:2001240","count":5},{"id":"GO:0001836","count":5},{"id":"GO:0043154","count":5},{"id":"GO:0030150","count":1}]},{"hash":"1820722836314579862","title":"Brain Adrenergic-Dopaminergic Signaling","description":"The terms cluster around neural signaling and neuroendocrine GPCR pathways in the brain, notably dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK and PLC pathways), brain renin-angiotensin involvement, and blood pressure regulation, suggesting a cohesive theme of brain-specific adrenergic/dopaminergic signaling. A few immune-related terms appear but are less representative of the main pattern.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":11},{"id":"GO:0001963","count":11},{"id":"GO:1900453","count":11},{"id":"GO:0001994","count":11},{"id":"GO:0071883","count":11}]},{"hash":"149712225066833498","title":"Growth Hormone and Glucagon Secretion Regulation","description":"This cluster is driven by GO terms for positive regulation of growth hormone secretion and glucagon secretion, plus endocrine pancreas development and overall organism growth, pointing to a shared theme of endocrine hormone secretion control. Some terms (like mRNA stabilization and a few obsolete terms) are ancillary, but the dominant signal is regulation of hormone release, especially GH and glucagon.","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060124","count":3},{"id":"GO:0010737","count":2},{"id":"GO:0035640","count":2},{"id":"GO:0070094","count":2},{"id":"GO:0040018","count":2}]},{"hash":"596049724915788944","title":"Ubiquitin-regulated TORC1 metabolic signaling","description":"The cluster\u2019s top GO terms point to protein polyubiquitination and positive regulation of TORC1 signaling, along with glucose-mediated signaling, suggesting a cohesive theme of ubiquitin-dependent control of nutrient-sensing growth pathways. While some terms are obsolete or immune-related, the strongest signal centers on post-translational modification guiding metabolic signaling through TORC1. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":2},{"id":"GO:0035948","count":2},{"id":"GO:1902661","count":2},{"id":"GO:1904263","count":2},{"id":"GO:0043981","count":2}]},{"hash":"1585086627656791946","title":"Actin cytoskeleton organization and cell adhesion","description":"The top terms cluster around actin dynamics and signaling that regulate cell shape and interactions\u2014microspike assembly, actin crosslinking, cortical patch localization, and Rho pathway control\u2014along with cell adhesion and polarity. Tissue-development terms appear less central to the core function, suggesting the primary theme is actin-driven cytoskeleton remodeling and cell\u2013cell/matrix adhesion.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900042","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0030035","count":5},{"id":"GO:0071260","count":4},{"id":"GO:0060065","count":4}]},{"hash":"1007583367632551084","title":"Brain energy metabolism","description":"The cluster is best described by brain development and energy metabolism, as it includes terms for brain structures (substantia nigra, cerebellum, brain development) and energy-related processes (phosphocreatine biosynthesis, creatine metabolic process). A few outliers (podosome assembly, maltose metabolism) are present but do not negate the main theme of neural development linked to energy buffering. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071800","count":2},{"id":"GO:0046314","count":1},{"id":"GO:0007420","count":1},{"id":"GO:0021762","count":1},{"id":"GO:0006950","count":1}]},{"hash":"718002618682361104","title":"ER Stress and Protein Quality Control","description":"The terms cluster around ubiquitin-proteasome\u2013mediated quality control, ER-associated degradation, and stress-responsive translation initiation, along with heat response and protein targeting/refolding. This points to a cohesive theme of cellular proteostasis management under ER stress, including degradation and regulated translation to cope with misfolded proteins.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071630","count":10},{"id":"GO:0030433","count":10},{"id":"GO:0006452","count":10},{"id":"GO:0070389","count":10},{"id":"GO:0009408","count":10}]},{"hash":"327017392400723692","title":"Unknown","description":"The Top Terms span cell cycle processes (centrosome cycle, DNA replication), viral genome replication, stress responses (misfolded protein response, nutrient/starvation responses), and vacuolar amino acid transport (proline, alanine, tyrosine). This mix lacks a single cohesive theme tying all proteins together, so a concise, representative label is not evident.","confidence":"","size":10,"edges":11,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0007098","count":2},{"id":"GO:0060669","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0019079","count":2},{"id":"GO:0071218","count":2}]},{"hash":"116059682040158433","title":"DNA replication and signaling pathway regulators","description":"This cluster centers on DNA-related processes (DNA replication and DNA-templated transcription) but also features multiple signaling pathways (T cell receptor signaling, Wnt signaling regulation, TNF signaling). The proteins appear to be involved in coordinating nuclear DNA processes with diverse signaling cascades, suggesting a regulatory role at the crossroads of cell cycle and cellular signaling. Confidence: Medium","confidence":"","size":10,"edges":37,"triangles":72,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0050852","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0051436","count":5},{"id":"GO:0090090","count":5}]},{"hash":"1073512651346164397","title":"Development and extracellular matrix remodeling","description":"The terms cluster around tissue remodeling and developmental processes: basement membrane disassembly and collagen catabolic process point to ECM turnover, while intramembranous ossification and neural precursor cell proliferation suggest developmental signaling. Wnt localization to extracellular region reinforces a signaling/developmental theme, with other terms (thyroid hormone response, neuropeptide catabolic process, T cell cytotoxicity) representing broader regulatory contexts. Overall, the dominant signal is ECM remodeling coupled with development/signaling pathways.","confidence":"Medium","size":10,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":3},{"id":"GO:0001913","count":3},{"id":"GO:0001957","count":3},{"id":"GO:0035593","count":3},{"id":"GO:0051603","count":3}]},{"hash":"2279744521126235437","title":"RNA processing and translation regulation","description":"Most top terms cluster around mRNA splicing, export, stabilization, poly(A) tail regulation, and translation initiation/miRNA-mediated silencing, with only a few immune signaling terms, suggesting the proteins primarily share RNA metabolism and gene expression control functions. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0046580","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0006376","count":2},{"id":"GO:0006406","count":2}]},{"hash":"698305491816262005","title":"Innate Immune Activation and Antigen Presentation","description":"The cluster centers on innate immune signaling and antigen presentation, with terms for NLRP3 inflammasome assembly, innate immune response, TNF and type II IFN pathways, dendritic cell antigen processing and MHC class I biosynthesis. Cytoskeletal remodeling terms (actin network formation and barbed-end capping) support immune cell movement and antigen processing, while cornea development appears less central. Overall, the dominant theme is immune activation and antigen presentation. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0032760","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0060335","count":6},{"id":"GO:0051639","count":6}]},{"hash":"166574662316067467","title":"Vertebrate Neural and Skeletal Development with Stress Response","description":"This cluster's top GO terms point to vertebrate development (neural tube closure, forebrain development, skeletal system development, multicellular organism development) and associated stress signaling (ER stress\u2013induced apoptosis, cellular response to cadmium), suggesting a cohesive theme of developmental programs modulated by cellular stress.","confidence":"Medium","size":10,"edges":30,"triangles":41,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071276","count":10},{"id":"GO:0000278","count":9},{"id":"GO:0050830","count":9},{"id":"GO:0001843","count":9},{"id":"GO:0007275","count":9}]},{"hash":"1973436870288384303","title":"Interferon-Driven Innate Immune Response","description":"The top GO terms are dominated by innate immune responses, including defense against protozoa and Gram-negative bacteria, and cellular responses to interferon-beta, pointing to an interferon-mediated innate immunity module. A few translation- and ribosome-related terms may reflect stress or antiviral translation control but do not override the immune-centric theme.","confidence":"Medium","size":10,"edges":14,"triangles":0,"max_degree":5,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:1903833","count":3},{"id":"GO:0006400","count":3},{"id":"GO:1901001","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1596086511928403264","title":"Collagen ECM Remodeling and Angiogenesis","description":"This cluster centers on collagen fibril organization and biosynthesis, pointing to extracellular matrix (ECM) remodeling. The presence of angiogenesis and regulation of endothelial processes, along with fibrinolysis, suggests a vascular remodeling/maintenance theme. Additional terms for exosomal secretion and transcription likely reflect shared regulatory activities in ECM dynamics and cell communication. Overall, a cohesive function in ECM remodeling coupled with angiogenic regulation best fits the data.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:2000352","count":3},{"id":"GO:1903543","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0001525","count":2}]},{"hash":"853967799244319047","title":"Potassium and Calcium Ion Transport","description":"The GO terms cluster around membrane transport of divalent/monovalent cations\u2014potassium import, intracellular potassium homeostasis, and calcium ion transport\u2014suggesting a core function in ion transport and membrane homeostasis. Other terms like inner ear receptor cell development and involuntary muscle contraction reflect related excitable-cell physiology that depends on these ions, while a couple of outliers (lipopolysaccharide biosynthesis) may be annotation noise or reflect mixed-origin proteins. Overall, the dominant signal is ion transport.","confidence":"Medium","size":10,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009636","count":3},{"id":"GO:0003011","count":2},{"id":"GO:0010107","count":2},{"id":"GO:0032534","count":2},{"id":"GO:0030007","count":2}]},{"hash":"1868305508516748523","title":"Glutamatergic Synapse Formation and Plasticity","description":"The cluster is strongest in terms related to excitatory synapses: dendritic spine morphogenesis, postsynaptic density assembly, and positive regulation of glutamatergic transmission, along with long-term synaptic depression, all pointing to formation and modulation of glutamatergic synapses. Immune-related GO terms and apoptotic process are present but less central, suggesting some cross-talk or multifunctionality rather than a primarily immune role. Thus, the label reflects the core neuronal synapse development and plasticity theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0071560","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0097107","count":2}]},{"hash":"2211445922276367955","title":"Gene expression regulation and protein homeostasis","description":"The top GO terms center on translation initiation/reinitiation, protein ubiquitination/ERAD, and mRNA splicing, with accompanying signals from GTPase regulation and growth factor\u2013related responses. This suggests a broad theme of coordinating gene expression at multiple levels (translational control, RNA processing) while maintaining proteome quality, rather than a single specific pathway. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":5},{"id":"GO:0002188","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0034260","count":4}]},{"hash":"1212531657635724742","title":"Cell Cycle Control and Golgi-to-ER Trafficking","description":"This cluster combines signals of cell cycle regulation (mitotic cycle, G0\u2192G1 transition, cell cycle checkpoints) with vesicle trafficking between the Golgi and ER, supported by GTPase activity and TGF-beta\u2013related responses, suggesting coordinated control of division and intracellular transport; a few chromatin-related terms may reflect broader nuclear regulation, but the dominant theme appears to be cell cycle and trafficking.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006890","count":3},{"id":"GO:0070317","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2}]},{"hash":"2282337173325119632","title":"Protein processing and trafficking","description":"The top GO terms point to protein handling and transport processes (Golgi vesicle transport, ERAD-related ubiquitin pathways, general protein processing and oligomerization, and ubiquitin regulation) with mRNA export adding a related macromolecule processing angle. While a couple terms (leading strand elongation, Complex III assembly) are broader cellular maintenance roles, the dominant signal is protein processing/trafficking and quality control.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048219","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0016485","count":3},{"id":"GO:0006272","count":3},{"id":"GO:0051260","count":3}]},{"hash":"433112627977342906","title":"Hematopoietic development and signaling","description":"This cluster prominently features GO terms tied to blood cell formation and stem cell maintenance (somatic stem cell population maintenance; erythrocyte differentiation), along with signaling-related processes (cellular response to nitric oxide; regulation of GTPase activity) and nuclear organization (PML body organization). Although there are also terms related to translational initiation, the strongest, recurrent themes are hematopoietic development and associated signaling, suggesting a label centered on blood cell formation and regulation.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0035019","count":3},{"id":"GO:0030578","count":3},{"id":"GO:0045648","count":3}]},{"hash":"1098175444924230156","title":"Unknown","description":"The terms are scattered across ubiquitin-mediated proteolysis, protein oligomerization, various development and cell-cycle processes, and disparate tissue contexts (plant, kidney, immune, neuron). With no shared pathway or strong functional theme and no edges linking proteins, there isn\u2019t a cohesive function to name this cluster beyond Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":5},{"id":"GO:0042787","count":5},{"id":"GO:0051865","count":3},{"id":"GO:2000176","count":3},{"id":"GO:0019762","count":3}]},{"hash":"537709459659129521","title":"Neural development signaling pathways","description":"This cluster is enriched for GO terms tied to nervous system and brain development, including axon guidance and morphogen signaling (Roundabout and Smoothened pathways), pointing to a cohesive theme of neural development and signaling; other terms reflect neuronal function (synaptic vesicle exocytosis) or shared signaling components, but the neural development focus is strongest.","confidence":"Medium","size":10,"edges":34,"triangles":57,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001822","count":9},{"id":"GO:0035385","count":9},{"id":"GO:0050852","count":9},{"id":"GO:2000300","count":9},{"id":"GO:0010796","count":9}]},{"hash":"1543593284149169597","title":"Ubiquitin-Dependent Proteolysis","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein catabolic processes and polyubiquitination, pointing to components of the ubiquitin\u2011proteasome system and ERAD; additional terms touch on cell-cycle regulation, DNA replication initiation, circadian rhythm, and stress responses, which are often regulated via targeted proteolysis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0000209","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0000083","count":4},{"id":"GO:1903378","count":4}]},{"hash":"1959590238175530771","title":"Cardiovascular and neural development with cytoskeleton dynamics","description":"This cluster is enriched for heart-related terms (heart development, SA node regulation, angiogenesis) and neural development (CNS development, axon extension regulation), suggesting coordinated cardiac and neural/vascular morphogenesis. It also includes cytoskeletal remodeling signals (actin cytoskeleton organization, podosome assembly), intracellular trafficking (COPI coating of Golgi vesicles), and PI3K/AKT signaling, all of which support tissue morphogenesis and cell migration during development. Placental development is also represented, indicating broader embryonic growth programs. Therefore the label Cardiovascular and neural development with cytoskeleton dynamics captures the main themes.","confidence":"Medium","size":10,"edges":13,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":2},{"id":"GO:0032956","count":2},{"id":"GO:0071803","count":2},{"id":"GO:0048205","count":2},{"id":"GO:0001893","count":2}]},{"hash":"2075328968673684485","title":"Immune and Developmental Signaling","description":"The top GO terms emphasize immune responses (adaptive/innate) and signaling regulation (NF-kappaB, EGFR, Rho, PLC), with developmental processes like CNS and heart development, suggesting a cohesive theme around immune signaling intersecting with development.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":3},{"id":"GO:0007417","count":2},{"id":"GO:0097324","count":2},{"id":"GO:0042058","count":2},{"id":"GO:1900042","count":2}]},{"hash":"892841515989898629","title":"p53-Mediated DNA Damage Response","description":"A strong signal in the term set is p53-dependent anti-apoptotic signaling in response to DNA damage, plus DNA repair processes like replication-born double-strand break repair and regulation of meiotic recombination, which together suggest a theme of cellular response to DNA damage and genome maintenance. Some terms point to transcriptional/epigenetic regulation and broader cellular processes, but the core appears to be DNA damage response coordinated with chromatin-related regulation. Confidence is based on the coherence of the DNA damage response and repair terms, tempered by a few outliers and obsolete terms that may reflect annotation noise.","confidence":"Medium","size":10,"edges":20,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1902166","count":3},{"id":"GO:2000179","count":3},{"id":"GO:0043046","count":2},{"id":"GO:0010520","count":2},{"id":"GO:1990414","count":2}]},{"hash":"2137616750290712695","title":"Cardiac signaling and heart development","description":"The terms cluster around heart formation and function (heart rudiment formation, cardiac muscle contraction, and regulation of heart contraction by chemical signals) as well as signaling processes (positive regulation of GTPase activity, GPCR internalization, and intracellular signal transduction) and catecholamine secretion, which together point to a cardiac signaling network. Some terms like intramembranous ossification and zygote asymmetric division are broader developmental processes and less specific to the heart, but the dominant pattern supports a cardiac signaling/development theme.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0001957","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0003315","count":2},{"id":"GO:0035556","count":2}]},{"hash":"236038376902790848","title":"Meiosis and cell cycle regulators","description":"This cluster centers on processes linked to cell division, particularly meiosis and mitosis (meiotic spindle elongation; regulation of meiotic cell cycle; mitotic nuclear membrane reassembly), with entries related to nuclear import and centrosome/ciliary docking that tie to cell cycle machinery. Additional terms on GTPase activity, mRNA transport, and signaling modulation (STAT/MAPK) fit into broader regulatory roles that support these core processes. Overall, the dominant pattern is meiotic and mitotic regulation with connected cellular transport and signaling functions.","confidence":"Medium","size":10,"edges":11,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042518","count":1},{"id":"GO:0006607","count":1},{"id":"GO:0000188","count":1},{"id":"GO:0007084","count":1},{"id":"GO:0043547","count":1}]},{"hash":"588815005462979921","title":"TGF-beta signaling regulation","description":"The top GO terms cluster around transforming growth factor beta stimulus and regulation of TGF-beta receptor signaling (including SMAD-related assembly), indicating a central theme of modulation of the TGF-beta pathway. While a few outlier terms touch other processes (photosystem, meristem maintenance, coronary morphogenesis), the dominant signal is TGF-beta signaling control, justifying the label. ","confidence":"Medium","size":10,"edges":13,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:1900116","count":3},{"id":"GO:0044179","count":3},{"id":"GO:0009405","count":3},{"id":"GO:0060982","count":2}]},{"hash":"1512435112899096217","title":"Sterol and Cofactor Biosynthesis","description":"The top GO term is ergosterol biosynthetic process, indicating a core function in sterol synthesis. Coexistence of porphyrin-containing compound biosynthesis and cobalamin biosynthesis suggests a broader biosynthetic focus on cofactors and tetrapyrroles, with ethanolamine metabolism linking to phospholipid biosynthesis. A few immune-related and DNA repair terms are present but appear sparse, so the dominant signal points to metabolic biosynthetic pathways rather than immune or repair functions.","confidence":"Medium","size":10,"edges":28,"triangles":24,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006696","count":2},{"id":"GO:0009236","count":1},{"id":"GO:0006779","count":1},{"id":"GO:0006580","count":1},{"id":"GO:0000738","count":1}]},{"hash":"1634544111435223960","title":"Synapse Assembly and Spine Morphogenesis","description":"Based on the GO terms, the cluster is dominated by neuronal synapse-related processes: localization of proteins to the synapse, dendritic spine morphogenesis, receptor clustering, and Rho signaling linked to cytoskeletal remodeling of spines. While a few terms pertain to broader development (angiogenesis, cardiac neural crest development), the core theme is synapse assembly and spine remodeling.","confidence":"High","size":10,"edges":16,"triangles":13,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035418","count":10},{"id":"GO:0008285","count":10},{"id":"GO:0007266","count":10},{"id":"GO:0060997","count":10},{"id":"GO:0043113","count":10}]},{"hash":"1941697856051986716","title":"Unknown","description":"The top GO terms cover a broad, unrelated mix: obsolete DNA methylation in gamete generation, obsolete regulation of histone methylation, guanine metabolism, camphor catabolism, capsule polysaccharide biosynthesis, aluminum ion response, glutamate biosynthesis, and various developmental processes. There is no coherent shared function or pathway linking these proteins, and several terms are obsolete; with no clear theme or connections, a reliable label cannot be inferred.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043046","count":10},{"id":"GO:0051572","count":10},{"id":"GO:0046098","count":10},{"id":"GO:0019383","count":10},{"id":"GO:0045227","count":10}]},{"hash":"804617665519296369","title":"Developmental morphogenesis and cytoskeleton regulation","description":"The terms cluster around morphogenesis across diverse tissues (plant ovule morphogenesis; metanephric S-shaped body morphogenesis; cervical development; spinal cord neuron differentiation; cerebellar precursor signaling) and cytoskeletal organization (actin, actomyosin). Other terms touch on gene regulation and signaling, but the dominant theme is development intertwined with cytoskeletal dynamics across species.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000637","count":7},{"id":"GO:0030835","count":7},{"id":"GO:0048482","count":7},{"id":"GO:0090334","count":7},{"id":"GO:0072284","count":7}]},{"hash":"770590592324491893","title":"Ribosome biogenesis and mitochondrial gene expression","description":"This cluster is dominated by GO terms for ribosome assembly (ribosome biogenesis, translation, rRNA and tRNA methylation, SSU-rRNA maturation) and mitochondrial transcription regulation, pointing to a module of ribosome production and mitochondrial translation. A few development terms (gastrulation, placenta development) are present but less representative; overall theme is ribosome biogenesis and mitochondrial gene expression.","confidence":"High","size":10,"edges":30,"triangles":56,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000462","count":7},{"id":"GO:0006412","count":7},{"id":"GO:0031167","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0007369","count":3}]},{"hash":"1887129463643018509","title":"Developmental signaling and RNA processing","description":"The cluster includes GO terms tied to developmental processes (angiogenesis, peripheral nervous system development, dendritic cell differentiation, neutrophil clearance) and to signaling pathway regulation (negative regulation of Wnt and Hedgehog signaling). In addition, it features several RNA metabolism terms (mRNA splice site recognition, export, stabilization, and miRNA-mediated silencing), suggesting proteins involved in both developmental signaling modulation and post-transcriptional gene regulation. Overall, the proteins seem connected to developmental signaling with coordinated regulation at the RNA level.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":2},{"id":"GO:0007422","count":2},{"id":"GO:0097350","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0045879","count":2}]},{"hash":"280843799918930303","title":"Developmental growth signaling regulators","description":"These proteins sit at the crossroads of multiple growth and differentiation pathways (Hippo, Wnt, ERK) and processes (keratinocyte differentiation, forebrain development, apoptosis), with both positive and negative regulation, and also tie into immune signaling (T cell receptor, GM-CSF) and TGF-\u03b2 regulation. The common theme is regulation of core signaling pathways that control development, tissue homeostasis, and cell fate decisions across contexts, rather than a single tissue-specific function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030216","count":8},{"id":"GO:0060044","count":8},{"id":"GO:0035329","count":8},{"id":"GO:0006915","count":8},{"id":"GO:0090263","count":8}]},{"hash":"1184636383093262257","title":"ER stress, protein folding, and redox homeostasis","description":"Proteins here cluster around the ER-centric quality-control program: unfolded protein response, ER-specific protein folding, chaperone-assisted refolding, and maintenance of redox balance. The inclusion of translation regulation under ER stress and protein repair further supports a cohesive ER stress response and maintenance of proteostasis.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":3},{"id":"GO:0006986","count":3},{"id":"GO:0034975","count":3},{"id":"GO:0070389","count":2},{"id":"GO:0036494","count":2}]},{"hash":"582730024512516619","title":"Energy metabolism and substrate catabolism","description":"The cluster is dominated by multiple substrate catabolic processes and core energy pathways, including adenine, D-galactonate, mandelate, and amino acid catabolism, as well as canonical glycolysis and gluconeogenesis. While a couple terms relate to vacuole regulation and apoptotic signaling, the strongest signal is general energy metabolism and degradation of diverse substrates, supporting a label focused on metabolism. ","confidence":"Medium","size":10,"edges":19,"triangles":14,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006146","count":4},{"id":"GO:0034194","count":3},{"id":"GO:0019596","count":3},{"id":"GO:0009405","count":3},{"id":"GO:0061621","count":3}]},{"hash":"963961487120996833","title":"Embryonic Organ Morphogenesis","description":"The GO terms show developmental and morphogenetic processes across multiple tissues: pancreatic development, left-right patterning, trophoblast differentiation, endocrine system development, and various heart and cartilage morphogenesis events. This points to a shared role in embryonic tissue patterning and organ formation rather than a single pathway, justifying a label centered on embryonic organ morphogenesis.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003323","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3}]},{"hash":"2288541725921456374","title":"Cardiac and muscle development","description":"The top GO terms cluster around heart and muscle formation and function (cardiac muscle cell development, vascular smooth muscle development, general muscle cell development, cardiac muscle tissue development, and heart contraction). The presence of swim bladder inflation aligns with muscle-organ development in a vertebrate context, while a couple of outlier terms (receptor internalization and obsolete biosynthetic processes) appear noise. Overall, the dominant signal is cardiac/muscle development and heart-related activity.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0055013","count":2},{"id":"GO:0097084","count":2},{"id":"GO:0048747","count":2},{"id":"GO:0048798","count":2},{"id":"GO:0007517","count":2}]},{"hash":"977314038588366601","title":"RNA transcription machinery and ribosome biogenesis","description":"The proteins are enriched for transcription-related GO terms across RNA polymerases I, II, and III, including transcription, elongation, termination, and RNA-templated transcription, along with ribosome biogenesis. This suggests a cohesive role in core transcriptional machinery and ribosome assembly, with some developmental terms appearing incidental.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":2},{"id":"GO:0006366","count":1},{"id":"GO:0042797","count":1},{"id":"GO:0006360","count":1},{"id":"GO:0001172","count":1}]},{"hash":"1248997215985950950","title":"Cellular stress response and growth regulation","description":"The cluster includes terms for defense against viruses, apoptosis, amino acid starvation response, and negative regulation of TORC1 signaling, plus protein homeostasis processes like ERAD and regulation of APP biosynthesis, suggesting a broad stress-response and metabolic growth control theme rather than a single pathway.","confidence":"Medium","size":10,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":2},{"id":"GO:0000462","count":2},{"id":"GO:0040016","count":2},{"id":"GO:0032929","count":2},{"id":"GO:0042985","count":2}]},{"hash":"95826182363316061","title":"Cardiovascular development and vascular formation","description":"This cluster is dominated by heart development, vasculogenesis, and angiogenesis terms, pointing to a module involved in cardiovascular tissue formation and blood vessel development. Additional terms on epithelial polarity and translation support the broader cellular machinery needed in developing tissues, while dephosphorylation and IL-2 related terms may reflect regulatory cross-talk. Overall, the primary theme appears to be cardiovascular development and vascularization.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0016311","count":2},{"id":"GO:0001570","count":2},{"id":"GO:0070183","count":2},{"id":"GO:0070184","count":2}]},{"hash":"782798974016975307","title":"Dopaminergic signaling and sensory processing","description":"This cluster is dominated by terms related to dopaminergic synaptic transmission, cocaine-related behavioral responses, and visual perception/learning, pointing to neural signaling and sensory processing as the core theme. Additional terms indicate modulation by inflammatory, prostaglandin, xenobiotic, and neurovascular signals, but the central function seems to be brain signaling and sensory/reward processing.","confidence":"Medium","size":10,"edges":34,"triangles":47,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001963","count":6},{"id":"GO:0002035","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0050728","count":5},{"id":"GO:0007601","count":5}]},{"hash":"1864036291866418767","title":"Brain Development and Neural Plasticity","description":"The top GO terms cluster around neural development and brain function (axonogenesis, substantia nigra development, astrocyte activation, and regulation of synaptic plasticity), with a few terms tied to EMT, hypoxia, and muscle/heart differentiation, but neural-related terms are dominant, supporting a brain-focused developmental/functional theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001015","count":4},{"id":"GO:0007409","count":3},{"id":"GO:0008016","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0051597","count":3}]},{"hash":"1303591535133966089","title":"Embryonic development and organogenesis","description":"This cluster centers on GO terms related to embryonic development, such as left/right patterning, placenta and pancreatic cell development, EMT during heart formation, and cartilage morphogenesis, indicating a unifying theme of developmental differentiation and organogenesis.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0060806","count":4},{"id":"GO:0035270","count":4},{"id":"GO:0003323","count":4}]},{"hash":"1224722329268980834","title":"RNA Pol II Transcription Regulation and Phosphorylation","description":"The strongest signals are for transcriptional control by RNA polymerase II (negative regulation, DNA-templated transcription) and phosphorylation, suggesting a core module around transcription regulation modulated by phosphorylation. The inclusion of insulin receptor signaling points to signaling pathways that can feed into transcriptional regulation, while the additional metabolic terms are broad cellular processes that accompany many regulatory networks. Overall, the dominant theme appears to be transcription regulation coupled with phosphorylation signaling.","confidence":"Medium","size":10,"edges":13,"triangles":2,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0016310","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0010729","count":3},{"id":"GO:0046022","count":3}]},{"hash":"1450505620904397110","title":"LPS-triggered Innate Immune and Inflammatory Signaling","description":"The cluster centers on lipopolysaccharide signaling and responses (lipopolysaccharide-mediated signaling, cellular response to lipopolysaccharide) and inflammatory regulation, including NF-kappaB pathways (notably non-canonical), GPCR signaling, and defense against viruses. Additional terms point to angiogenesis modulation, chemokine signaling feedback, and mechanotransduction, suggesting a coordinated innate immune/inflammatory program with vascular and chemokine regulation. Overall, these proteins appear to participate in LPS-driven innate immune activation and inflammatory signaling, with regulatory cross-talk.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0031663","count":6},{"id":"GO:0071260","count":5},{"id":"GO:0016525","count":4},{"id":"GO:0050729","count":4},{"id":"GO:0042346","count":4}]},{"hash":"444497864120718679","title":"Cytoskeletal Dynamics and Cell-adhesion Regulation","description":"The top terms include podosome assembly, actomyosin structure organization, and regulation of integrin activation, which together point to cytoskeletal remodeling and cell adhesion/junction processes. Paranjonal junction assembly and related adhesion terms further support this theme, while signaling-related terms (e.g., TGF-beta and testosterone responses) may regulate these structural components. The cluster therefore seems centered on cytoskeletal dynamics and cell-adhesion regulation rather than a single metabolic process. Confidence: Medium","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0001951","count":9},{"id":"GO:0071560","count":9},{"id":"GO:0022614","count":9},{"id":"GO:0045571","count":9},{"id":"GO:0033623","count":9}]},{"hash":"81771591846727001","title":"RNA processing and ribosome maturation","description":"This cluster is dominated by RNA-related terms: RNA splicing, mRNA processing, spliceosomal complex assembly, and maturation of rRNA (LSU and 5.8S) along with guanine-N7 methylation, indicating a cohesive theme of RNA processing and ribosome biogenesis; the other terms (spinal cord development, flight behavior, cohesion) are less central to the core theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008380","count":2},{"id":"GO:0007064","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0000463","count":2}]},{"hash":"1479126801616573925","title":"Brain adrenergic signaling and dopaminergic synapse","description":"This cluster is dominated by terms related to brain GPCR signaling, especially adrenergic receptor pathways (MAPK-activating and PLC-activating) and dopaminergic synaptic transmission, along with related vascular regulation terms. While a couple terms touch on immune differentiation, the core theme points to neuronal adrenergic/dopaminergic signaling and associated downstream cascades.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":10},{"id":"GO:0001963","count":10},{"id":"GO:1900453","count":10},{"id":"GO:0001994","count":10},{"id":"GO:0071883","count":10}]},{"hash":"859290215191241577","title":"Golgi-ER vesicle trafficking and immune degranulation","description":"This cluster's top GO terms center on ER-to-Golgi and Golgi-to-ER transport, endosome-to-Golgi routing, SNARE-mediated vesicle fusion, and general protein transport, plus degranulation in neutrophils, NK cells, and eosinophils. Together they point to a common function: secretory vesicle trafficking and granule exocytosis in immune cells.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0006890","count":5},{"id":"GO:0042147","count":5},{"id":"GO:0043312","count":5},{"id":"GO:0048280","count":5}]},{"hash":"670811044362677952","title":"Brain adrenergic and dopaminergic signaling","description":"This cluster is dominated by terms tied to neuronal signaling and autonomic regulation, especially dopaminergic synaptic transmission, brain renin-angiotensin signaling, and adrenergic receptor\u2013mediated pathways (MAPK and PLC signaling) that influence blood pressure. A few immune-related terms appear, but the central theme is brain/neuronal adrenergic-dopaminergic signaling.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":4},{"id":"GO:0001963","count":4},{"id":"GO:1900453","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0071883","count":4}]},{"hash":"255328386607481866","title":"Axon Guidance and Neurite Morphogenesis","description":"Dominant GO terms point to semaphorin-plexin signaling, axon guidance, dendrite self-avoidance, axonal fasciculation, projection extension, and regulation of synapse assembly, all core to neural connectivity and neurite morphogenesis. A few terms about morphogenesis in other tissues appear, but the prevalent pattern strongly supports neural development and cell-adhesion\u2013mediated wiring of circuits.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1902287","count":4},{"id":"GO:1900220","count":4},{"id":"GO:0051963","count":4},{"id":"GO:0010693","count":4},{"id":"GO:0001886","count":4}]},{"hash":"1963459046801035698","title":"Neurodevelopment and cell cycle regulation","description":"The top GO terms cluster around developmental processes, with neural-related terms such as axonogenesis, Schwann cell development, and visual perception, alongside cell cycle control terms like mitotic cell cycle and G2/M transition. This pattern suggests proteins involved in coordinating growth/differentiation with cell division, common in neural development and tissue morphogenesis. Some terms (e.g., heart development) reflect broader developmental roles, and one plant-specific term (abscisic acid-activated signaling) may be annotation noise, but it does not overwhelm the neural/developmental signal.","confidence":"Medium","size":9,"edges":31,"triangles":54,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0043065","count":5},{"id":"GO:0007601","count":5},{"id":"GO:0000086","count":5}]},{"hash":"1770765570513834984","title":"Mitotic spindle and cytokinesis proteins","description":"This cluster is dominated by mitosis- and cell division-related terms (mitotic cell cycle, spindle assembly, chromosome alignment, centrosome separation, and cytokinesis/contractile ring activity). While there are a few peripheral terms about intraciliary transport and ribosomal export, the core signal points to proteins involved in mitotic progression and cytokinesis.","confidence":"High","size":9,"edges":31,"triangles":55,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0035735","count":3},{"id":"GO:0000056","count":2},{"id":"GO:0007100","count":2}]},{"hash":"1109800879166487132","title":"Unknown","description":"The Top Terms are highly diverse, including placenta development, drug response, nuclear import regulation, proteasome regulation, cell size, telomerase activity, DNA topology, integrin signaling, and ion transport. There is no clear, cohesive functional theme linking these terms, so a single informative label cannot be reliably assigned.","confidence":"","size":9,"edges":23,"triangles":33,"max_degree":7,"top_function":"protein folding","top_go_terms":[{"id":"GO:0001890","count":4},{"id":"GO:0042220","count":4},{"id":"GO:0032092","count":4},{"id":"GO:0033160","count":4},{"id":"GO:0032435","count":4}]},{"hash":"1960201432037663794","title":"Unknown","description":"The top GO terms include sperm capacitation, ion transport and membrane potential regulation, RNA decay, DNA replication, development, and sporulation, spanning reproductive and basic cellular processes with no single cohesive theme. The lack of edges and the diverse functions suggest these proteins do not share a clear common role in this cluster, so an Unknown label is appropriate.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048240","count":3},{"id":"GO:0006813","count":3},{"id":"GO:0000184","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0009791","count":2}]},{"hash":"327863413848518873","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034476","count":9},{"id":"GO:1903608","count":9},{"id":"GO:0006306","count":9},{"id":"GO:1903241","count":9},{"id":"GO:0009432","count":9}]},{"hash":"1072641762295874072","title":"Cell Adhesion and Migration","description":"The GO terms point to a shared theme of cells sticking to each other or to the extracellular matrix and then moving or being guided (heterophilic adhesion, receptor clustering, cell-matrix adhesion, leukocyte tethering/rolling, and sprouting angiogenesis). Cytoskeletal regulation (negative regulation of Rho signaling) and negative chemotaxis further support a focus on dynamic cell movement and navigation across different cell types, including immune and endothelial contexts. This combination best matches a cohesive label of adhesion-driven cell migration rather than a single, narrower pathway.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":4},{"id":"GO:0043113","count":4},{"id":"GO:0050901","count":4},{"id":"GO:0035024","count":3},{"id":"GO:0032516","count":3}]},{"hash":"77723479104695373","title":"Neural development and balance","description":"Most of the top GO terms cluster around nervous system development and balance-related functions (neural tube development, inner ear morphogenesis, neuromuscular processes controlling balance, GABA shunt). While there are a few metabolic or miscellaneous embryonic terms present, the dominant pattern is neural development with vestibular/motor guidance, suggesting these proteins participate in CNS formation and balance control.","confidence":"High","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0015976","count":9},{"id":"GO:0042472","count":9},{"id":"GO:0032180","count":9},{"id":"GO:0006540","count":9},{"id":"GO:0050885","count":9}]},{"hash":"969395369456635554","title":"Purkinje Cell Development and Brain Morphogenesis","description":"The top GO terms point to neural development and brain structure formation, including Purkinje cell migration, radial glia-guided neuronal movement, brain morphogenesis, and epithelial morphogenesis with apical junction assembly. Rho signaling and broader regulatory processes (estrogen response, protein heterooligomerization) appear as supporting layers rather than central themes, reinforcing a neural-development focus. This cluster is best described as Purkinje cell development intertwined with brain morphogenesis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086073","count":2},{"id":"GO:0071681","count":2},{"id":"GO:0048854","count":2},{"id":"GO:0002009","count":2},{"id":"GO:0043297","count":2}]},{"hash":"751326640682397436","title":"Mitotic division and ER-Golgi vesicle trafficking","description":"The top GO terms cluster around mitosis (mitotic cell cycle, cell division, mitotic spindle assembly) and vesicle trafficking between the ER and Golgi (COPII-coated vesicle budding, ER\u2013Golgi transport). This points to proteins that participate in cell proliferation while also coordinating membrane trafficking, a combination often seen in dividing or developing cells. Developmental terms like brain development and multicellular growth support this broader context, but the core signal is mitosis paired with secretory pathway transport.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":8},{"id":"GO:0051301","count":8},{"id":"GO:0006890","count":8},{"id":"GO:0007420","count":8},{"id":"GO:0090307","count":8}]},{"hash":"1544743746970615684","title":"Diverse membrane solute transporters","description":"The GO terms mainly describe transmembrane transport of various solutes (fructose, aspartate, bicarbonate, sulfate, oxalate) and related membrane potential regulation, with a few terms pointing to broader membrane-associated processes (gastric acid secretion, sperm capacitation, sporulation). The common thread is membrane transport activity across different substrates, so this label is representative.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051000","count":2},{"id":"GO:0015755","count":2},{"id":"GO:0042391","count":2},{"id":"GO:0030435","count":2},{"id":"GO:0089712","count":2}]},{"hash":"948641517564389885","title":"Regulation of vesicle trafficking and signaling","description":"This cluster repeatedly shows terms tied to how cells regulate signaling pathways (Rho, Ras) and to vesicle-related steps (synaptic vesicle priming, acrosome reaction, phagocytic vesicle localization). Although some terms involve unrelated contexts (blood vessel remodeling, neutrophil degranulation, stomatal closure, cortical neuron migration), the unifying theme is modulation of vesicle trafficking and signal transduction.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0060313","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0043314","count":8},{"id":"GO:0046580","count":8},{"id":"GO:0016082","count":8}]},{"hash":"358450110949363183","title":"Ubiquitin-regulated adaptive immune signaling","description":"This cluster centers on ubiquitin-mediated regulation (ubiquitin-dependent catabolic process and protein ubiquitination) alongside robust adaptive immune signaling, including T cell homeostasis, B cell receptor signaling, and defense against virus, plus TNF signaling/NF-kB-related pathways. These together suggest a coherent theme: ubiquitin-controlled modulation of immune signaling and antiviral responses. The miRNA silencing term is secondary to the dominant immune-ubiquitin axis.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0016567","count":4},{"id":"GO:2000637","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0051092","count":3}]},{"hash":"1011595663821585150","title":"Unknown","description":"The GO terms span potassium transport, light-response signaling, endothelial and epithelial morphogenesis, dendrite development, transcription regulation depending on carbon source, histidine phosphorylation, protein homooligomerization, and cardiac muscle depolarization. They do not point to a single cohesive function or pathway, so a specific, representative label cannot be confidently assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0006813","count":9},{"id":"GO:0010201","count":8},{"id":"GO:0097497","count":8},{"id":"GO:0061415","count":8},{"id":"GO:0061414","count":8}]},{"hash":"1261776270033040856","title":"Spliceosome and RNA processing","description":"The top GO terms cluster around mRNA splicing via the spliceosome, spliceosomal snRNP and complex assembly, and related RNA maturation/processing processes (including SSU-rRNA maturation, histone mRNA metabolism, and nuclear import). P-body assembly also ties to RNA regulation. A few terms touch on cell cycle or stress, but the dominant theme is RNA splicing and RNA metabolism.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0030490","count":8},{"id":"GO:0070317","count":8},{"id":"GO:0000387","count":8},{"id":"GO:0042633","count":8}]},{"hash":"1218035731234347624","title":"Epithelial Polarity and Adherens Junction Assembly","description":"Most terms point to epithelial cell polarity and junction biology\u2014apical protein localization, establishment of epithelial polarity, zonula adherens assembly, and polarized differentiation\u2014with supporting trafficking terms (intra-Golgi transport, SNARE complex assembly) and related organ morphogenesis (lung tubulogenesis, kidney collecting duct development). This implies a cluster whose proteins work to establish and maintain epithelial polarity and adherens junctions.","confidence":"High","size":9,"edges":12,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045176","count":4},{"id":"GO:0045197","count":4},{"id":"GO:0072205","count":4},{"id":"GO:0030901","count":4},{"id":"GO:0071896","count":4}]},{"hash":"1572405497514125906","title":"ECM remodeling and cell junction assembly","description":"Based on GO terms with high representation: collagen fibril organization, slit diaphragm assembly, synapse organization, and angiogenesis, the proteins point to extracellular matrix remodeling and intercellular junction formation. Additional signals for PI3K-Akt pathway and substrate-dependent cell migration support adhesion and morphogenesis; some terms like NK differentiation or vestibular morphogenesis are broader annotations but do not override the central theme of ECM/adhesion and junction dynamics.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001779","count":7},{"id":"GO:0043491","count":7},{"id":"GO:0030199","count":6},{"id":"GO:0060116","count":6},{"id":"GO:1904237","count":6}]},{"hash":"810873757784203808","title":"ECM-Driven Tissue Morphogenesis","description":"The cluster includes collagen fibril organization, cell migration/adhesion, angiogenesis, synapse organization, and barrier-related structures (slit diaphragm), all tied together by PI3K/AKT signaling. These terms collectively point to development and tissue organization guided by extracellular matrix remodeling and signaling across multiple organs (vasculature, nervous system, epithelia). So, the label reflects a common theme of ECM-mediated morphogenesis.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001779","count":8},{"id":"GO:0043491","count":8},{"id":"GO:0030199","count":7},{"id":"GO:0060116","count":7},{"id":"GO:1904237","count":7}]},{"hash":"969721048168699564","title":"Cardiac development and GPCR signaling","description":"The top GO terms strongly point to heart development and heart rudiment formation, with concurrent GPCR-related signaling (acetylcholine receptor signaling, GPCR internalization) and catecholamine secretion, suggesting a cohesive theme of cardiac development tied to GPCR-mediated pathways. Some peripheral terms (NF-kappaB activation by symbionts, zygote division) appear less central, but the dominant pattern supports a cardiac development plus GPCR signaling cluster.","confidence":"High","size":9,"edges":9,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0003315","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0003108","count":2},{"id":"GO:0043547","count":2}]},{"hash":"396419890016017133","title":"NF-kB-driven inflammatory and cell-survival signaling","description":"This cluster is dominated by GO terms tied to NF-kappaB signaling (canonical and general transcription factor activity), inflammatory responses (LPS signaling), and anti-apoptotic/pro-survival processes, with contributions from autophagy regulation and PI3K/Akt signaling. While some terms touch on angiogenesis and tight junctions, the core theme appears to be NF-kB\u2013mediated inflammation and cell survival pathways.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010446","count":2},{"id":"GO:0010508","count":2},{"id":"GO:0051897","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1161439713779364863","title":"Neuronal synapse formation and signaling","description":"Dominant GO terms point to synapse biology: synapse organization, receptor localization to the synapse, dendrite development, and short-term synaptic potentiation, with phosphatidylinositol-mediated signaling supporting neuronal signaling. The presence of cortex-related migration and development terms further supports a neuronal/cortical synaptic theme. A couple of outlier terms (mismatch repair, phagocytic vesicle protein localization) are less consistent with this theme.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048015","count":9},{"id":"GO:0050808","count":8},{"id":"GO:0021814","count":8},{"id":"GO:0097120","count":8},{"id":"GO:0016358","count":8}]},{"hash":"1795170911785017122","title":"Cytokine signaling and inflammatory response","description":"The cluster is centered on immune signaling and cytokine production, with frequent terms for LPS response, positive regulation of IL-6 and GM-CSF, STAT phosphorylation, and PI3K/AKT pathway activity, indicating coordinated inflammatory signaling; other terms like insulin/ethanol response may reflect broader stress signaling linked to these pathways.","confidence":"High","size":9,"edges":33,"triangles":64,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032868","count":4},{"id":"GO:0045471","count":4},{"id":"GO:0042517","count":4},{"id":"GO:0055091","count":4},{"id":"GO:0010628","count":4}]},{"hash":"78096388886922523","title":"Epigenetic Transcription and Cell Cycle Regulation","description":"The cluster centers on nuclear processes: DNA-templated transcription and chromatin organization, with signals of epigenetic control (histone acetylation) and cell cycle regulation (mitotic cycle, cell cycle checkpoint). TGF-beta response suggests growth-factor\u2013driven transcriptional changes, reinforcing a theme of transcriptional regulation linked to proliferation. Some terms, like sensory perception of taste, may reflect annotation noise rather than core function. ","confidence":"Medium","size":9,"edges":16,"triangles":13,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0072137","count":2},{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0071560","count":2}]},{"hash":"2093233154618878335","title":"Metabolic signaling and cardiovascular development","description":"The top GO terms point to insulin-stimulated glucose import, nitric oxide biosynthesis (a cardiovascular vascular function), brown fat differentiation, and heart development, suggesting a theme centered on energy metabolism linked to cardiovascular development. Additional terms like receptor-mediated endocytosis and hydrogen peroxide catabolism support general metabolic regulation and cellular signaling roles, reinforcing a cohesive metabolic-CV development emphasis rather than a single narrow function.","confidence":"Medium","size":9,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0044381","count":2},{"id":"GO:0045429","count":1},{"id":"GO:0043353","count":1},{"id":"GO:0042744","count":1},{"id":"GO:0010764","count":1}]},{"hash":"1250089189556072702","title":"Cytokine signaling and immune cell migration","description":"This cluster is dominated by immune-related functions: IL-4 production, B cell affinity maturation, NK T cell differentiation, and cellular responses to IL-7, pointing to lymphocyte activation and cytokine signaling. Supporting terms like regulation of Rho and small GTPase-mediated signal transduction, as well as GPCR desensitization, align with cytoskeletal changes and signaling in migrating immune cells. Some terms (heart development, insulin receptor signaling) appear less central and may reflect broader signaling cross-talk, but the prevailing theme is cytokine-driven immune signaling and cell movement.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0002344","count":4},{"id":"GO:0035023","count":4}]},{"hash":"2267906456994602409","title":"Neurodevelopment and sensory function","description":"This cluster is enriched with neural development processes (Notch signaling, myelination, astrocyte migration) and sensory system activities (sound perception, balance), plus calcium homeostasis critical for neurons. The inclusion of extracellular matrix remodeling (hyaluronan and CSPG catabolism) supports neural tissue remodeling, pointing to nervous system development and function rather than a single pathway.","confidence":"High","size":9,"edges":12,"triangles":4,"max_degree":7,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0006874","count":4},{"id":"GO:0042552","count":4},{"id":"GO:0030214","count":4},{"id":"GO:0001501","count":4},{"id":"GO:0007219","count":3}]},{"hash":"198442835409137216","title":"STAT Tyrosine Phosphorylation Regulators","description":"This cluster is strongestly tied to regulation of tyrosine phosphorylation of STAT proteins (JAK-STAT signaling), with two GO terms explicitly indicating positive regulation of STAT phosphorylation. Additional terms hint at roles in differentiation, proliferation, apoptosis, xenobiotic response, and behavior, suggesting these proteins participate in signaling networks that control development and stress responses, but the STAT regulation signal provides the most coherent core functional theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042523","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0042517","count":3},{"id":"GO:0008344","count":2},{"id":"GO:1901998","count":2}]},{"hash":"1820428570650294732","title":"Podocyte and glomerular basement membrane development","description":"The cluster is clearly enriched for kidney-related processes, especially podocyte development (positive regulation of metanephric podocyte development), glomerular basement membrane development, and renal albumin handling, supported by collagen fibril organization in the extracellular matrix. While there are a few other terms pointing to broader development and stress responses, the dominant theme is glomerular filtration structure formation and maturation, suggesting these proteins function together in podocyte- and basement membrane\u2013associated renal development. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":2},{"id":"GO:0030199","count":1},{"id":"GO:2000478","count":1},{"id":"GO:0032836","count":1},{"id":"GO:0070994","count":1}]},{"hash":"2005108431452539223","title":"Neural development and vesicle priming","description":"The Top Terms cluster around brain/spinal cord and retina development, plus processes tied to vesicle priming and exocytosis (synaptic vesicle priming and acrosome reaction). Microtubule-based movement supports neuronal transport, and regulation of Rho/Ras signaling fits developmental and cytoskeletal control. While a few terms relate to blood vessel/immune regulation, the dominant theme is neural development together with vesicle priming/exocytosis.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0060313","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0043314","count":4},{"id":"GO:0046580","count":4},{"id":"GO:0016082","count":4}]},{"hash":"58326201426350114","title":"Innate immune signaling with endothelial activation","description":"Top terms cluster around innate immune response, NK cell regulation, cytokine production, and key signaling pathways (NF-kappaB, STAT), plus endothelial cell adhesion/morphogenesis and hypersensitivity regulation. This pattern suggests a coordinated immune-vascular activation during inflammation and allergic responses, rather than a neural or purely structural role. Myelination appears to be an outlier in this set. ","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0002859","count":3},{"id":"GO:0002720","count":3},{"id":"GO:0090673","count":3},{"id":"GO:0001798","count":3}]},{"hash":"344392996962336611","title":"Diverse Stimulus Response Signaling","description":"The proteins appear connected through a broad theme of signaling in response to various stimuli, including immune-like responses to dsRNA and bacterial components, plus growth/development signals (angiogenesis, cardiac neural crest development, filamentous growth). The mix spans stress, immune, and developmental signaling rather than a single, cohesive function, so a broad label capturing stimulus-responsive signaling fits best.","confidence":"Medium","size":9,"edges":22,"triangles":30,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":9},{"id":"GO:0090606","count":9},{"id":"GO:0000186","count":9},{"id":"GO:0061308","count":9},{"id":"GO:0001525","count":9}]},{"hash":"373309125402818280","title":"Unknown","description":"The top GO terms cover a wide range of processes from biofilm formation and dsRNA response to angiogenesis, apoptosis regulation, spindle assembly, and specific developmental processes. This diversity suggests there is no single, cohesive function tying these proteins together in this cluster, and annotations may reflect broad signaling or cross-species differences rather than a unified biological theme.","confidence":"","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":9},{"id":"GO:0090606","count":9},{"id":"GO:0000186","count":9},{"id":"GO:0061308","count":9},{"id":"GO:0001525","count":9}]},{"hash":"1728786833764277974","title":"ER Membrane Targeting and Cotranslational Translocation","description":"The top GO terms cluster around translation initiation and preinitiation complex formation, plus several terms for targeting proteins to membranes, especially the ER membrane, via SRP-dependent cotranslational pathways and Sec-dependent transport. This points to a cohesive theme of proteins involved in translating and efficiently delivering nascent polypeptides to the endoplasmic reticulum membrane for proper processing, with some developmental terms possibly reflecting tissue-specific expression. ","confidence":"Medium","size":9,"edges":23,"triangles":29,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0031204","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007275","count":2}]},{"hash":"2028306625837286966","title":"P53-Mediated DNA Damage Response and Translation Regulation","description":"This cluster centers on gene expression control under DNA damage/UV stress, combining translation regulation (and ribosome biogenesis) with transcription elongation and p53-mediated DNA damage response signals. The presence of GO terms for translation, transcription elongation, ribosome biogenesis, and p53-driven apoptotic signaling suggests proteins in this cluster coordinate transcription and translation to manage stress-induced cell fate.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:1904803","count":2},{"id":"GO:0006977","count":2},{"id":"GO:1902164","count":2},{"id":"GO:0031564","count":2}]},{"hash":"1727786086533646120","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":26,"triangles":45,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":2},{"id":"GO:0071353","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0046677","count":2}]},{"hash":"280195433897044995","title":"RNA Splicing and Circadian Regulation","description":"The top GO terms prominently point to RNA processing and splicing (regulation of alternative mRNA splicing, RNA splicing), with an additional circadian-related term (temperature compensation of the circadian clock), suggesting a cluster centered on RNA maturation linked to circadian control. Other terms hint at broader RNA metabolism and post-translational regulation, but the splicing/circadian theme is strongest.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":4},{"id":"GO:0071600","count":3},{"id":"GO:0008380","count":3},{"id":"GO:0010378","count":3},{"id":"GO:0036292","count":3}]},{"hash":"1540039407350487594","title":"Embryonic development and tissue remodeling","description":"The top GO terms span developmental signaling (Wnt pathway, embryonic skeletal development, follicle cell formation, germarium-derived cyst encapsulation) and extracellular remodeling processes (plasminogen activation, fibrinolysis, angiogenesis), suggesting a theme of embryogenesis/morphogenesis with tissue remodeling. The presence of immune-related terms is ancillary, not defining a single cohesive function, hence a moderate confidence. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031639","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0045766","count":2},{"id":"GO:0042730","count":2}]},{"hash":"1534580238720663897","title":"Calcineurin-NFAT Signaling Regulation and Membrane Proteolysis","description":"The dominant GO terms point to regulation of the calcineurin-NFAT signaling cascade, with additional related processes like membrane protein ectodomain/intracellular domain proteolysis. Some terms (thyroid hormone metabolism, cardiac hypertrophy, oxidative stress) further support NFAT-linked signaling and stress responses, giving a coherent theme around NFAT pathway modulation and receptor proteolysis, despite a few outliers.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070886","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0051533","count":2},{"id":"GO:0006509","count":2},{"id":"GO:0031293","count":2}]},{"hash":"229906362073791667","title":"Unknown","description":"The GO terms shown cover immune system processes (B cell homeostasis, T cell proliferation, T cell costimulation) and nervous/visual functions (paranodal junction assembly, visual perception, transmission of nerve impulse), plus general signaling-related terms. This mix suggests no single cohesive function or pathway tying all proteins together, making a concise, specific label unreliable.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001782","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0007601","count":2},{"id":"GO:2001046","count":2},{"id":"GO:0042102","count":2}]},{"hash":"105693437855209786","title":"Unknown","description":"The top GO terms cover a wide, seemingly unrelated mix: plant nitrate metabolism and transport, plant hormone signaling (auxin, gibberellin), animal development processes (embryo implantation, blood vessel maturation, fibroblast proliferation), and immunity (antibacterial humoral response) plus herbicide response. There is no clear, single functional theme tying these terms together, so a specific, representative cluster label isn\u2019t apparent.","confidence":"","size":9,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0048146","count":2},{"id":"GO:0001955","count":2},{"id":"GO:0007566","count":2}]},{"hash":"2010665810763388053","title":"Central carbon metabolism and amino acid catabolism","description":"The top GO terms are dominated by glycolysis, the TCA cycle, gluconeogenesis, and pathways feeding acetyl-CoA from amino acids (leucine, lysine), indicating core energy production and carbon metabolism. Minor terms like cellular response to cAMP or sodium ion transport exist but do not define the cluster\u2019s main function. Confident this reflects a central metabolism theme. ","confidence":"High","size":9,"edges":10,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006099","count":4},{"id":"GO:0019878","count":3},{"id":"GO:0006552","count":2},{"id":"GO:0006096","count":2}]},{"hash":"1854884876941753363","title":"Bacterial cell wall synthesis and central metabolism","description":"The cluster is dominated by terms related to peptidoglycan biosynthesis, cell wall organization, and regulation of cell shape, which point to bacterial envelope construction and morphology. In addition, glycolytic process and oxaloacetate metabolic process indicate core metabolic pathways feeding these activities. While some terms (e.g., systemic acquired resistance) seem tangential or misannotated, the core theme ties strongly to bacterial cell wall synthesis and central metabolism.","confidence":"High","size":9,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0033512","count":3},{"id":"GO:0006552","count":2},{"id":"GO:0006096","count":2},{"id":"GO:0071320","count":2}]},{"hash":"1791864840115696188","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0006808","count":2},{"id":"GO:0006203","count":2},{"id":"GO:0042245","count":2},{"id":"GO:0015970","count":2}]},{"hash":"325988977840886638","title":"Steroid Hormone Biosynthesis and Metabolism","description":"This cluster shows multiple GO terms tied to steroid hormone production and metabolism (glucocorticoid biosynthesis, C21-steroid hormone metabolic process, testosterone biosynthetic process, androgen metabolic process) and related lipid biosynthesis (sphingolipid biosynthetic process). While an inflammatory response term appears, the dominant signal is steroid hormone and lipid biosynthesis, suggesting the proteins collectively participate in steroid hormone biosynthesis and related metabolic pathways.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0017000","count":1},{"id":"GO:0042619","count":1},{"id":"GO:0006704","count":1},{"id":"GO:0008209","count":1}]},{"hash":"84019718561561352","title":"Innate immune signaling and extracellular matrix remodeling","description":"The top terms include macrophage activation, defense response to Gram-positive bacteria, and Toll-like receptor signaling, pointing to innate immune activity. Simultaneously, collagen fibril organization, chondroitin sulfate cross-linking, and bone development suggest extracellular matrix (ECM) remodeling. Together, they imply a cluster focused on immune-driven tissue remodeling rather than a single pure pathway. Some terms may reflect annotation noise (plant-specific or obsolete terms), but the dominant theme appears to be immune-associated ECM remodeling.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019800","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0030199","count":2},{"id":"GO:0009934","count":2},{"id":"GO:0090141","count":2}]},{"hash":"1546929783095008871","title":"Immune and Reproductive Development Signaling","description":"The top GO terms cluster around immune functions (B cell differentiation and proliferation, IL-12 production) alongside reproductive processes (acrosome reaction, egg activation) and developmental signaling (angiogenesis, IGF receptor signaling, GPCR pathways). This suggests a broad set of signaling roles connecting immune and reproductive development rather than a single cohesive pathway, so the label reflects a general developmental signaling theme across these domains.","confidence":"Medium","size":9,"edges":8,"triangles":2,"max_degree":3,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0002337","count":8},{"id":"GO:0048009","count":8},{"id":"GO:0007340","count":8},{"id":"GO:0032237","count":8},{"id":"GO:0035477","count":8}]},{"hash":"64497380176874958","title":"B cell activation and antigen presentation","description":"These proteins cluster around B cell\u2013centric adaptive immunity: multiple terms highlight B cell receptor signaling, promotion of B cell activation, antigen processing and presentation via MHC II, and T cell co-stimulation, with supporting innate processes such as phagocytosis and complement activation.","confidence":"High","size":9,"edges":16,"triangles":9,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":7},{"id":"GO:0006911","count":7},{"id":"GO:0050871","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0006958","count":6}]},{"hash":"429414712127240861","title":"Centrosome cycle and meiotic spindle regulation","description":"GO terms are dominated by centrosome cycle, spindle assembly, and regulation of meiotic nuclear division, suggesting a coherent cluster of proteins involved in centrosome dynamics and chromosome segregation during meiosis. Other terms touch on nuclear transport and DNA damage response but do not override the core theme.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007098","count":2},{"id":"GO:0051225","count":2},{"id":"GO:0035041","count":1},{"id":"GO:0010825","count":1},{"id":"GO:0000056","count":1}]},{"hash":"2025248456364973199","title":"Translational Initiation and Reinitiation","description":"Based on the dominant GO terms, this cluster centers on translation initiation and reinitiation, including translation reinitiation, formation of the translation preinitiation complex, and regulation of translational initiation, with supporting signal from IRES-dependent viral translational initiation. The presence of these terms across the proteins indicates a functional grouping around the control points of initiating protein synthesis, rather than other processes like splicing or ER-associated degradation, which are less central here.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0048025","count":3},{"id":"GO:0075522","count":3},{"id":"GO:0006446","count":3}]},{"hash":"1459921962244375934","title":"Olfactory and Thermosensory Perception","description":"The set of top GO terms is dominated by sensory perception and responses to chemical/temperature cues (smell, olfactory behavior, thermotaxis, CO2 detection). Terms about membrane potential regulation align with neuronal signaling, supporting a sensory neuron\u2013focused cluster. A few outlier terms about sarcomere organization and spicule insertion may reflect multifunctional annotations but do not override the overall sensory theme.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0043052","count":8},{"id":"GO:0003031","count":8},{"id":"GO:0060298","count":8},{"id":"GO:0007608","count":8},{"id":"GO:0042391","count":8}]},{"hash":"1086316369527543103","title":"Neuronal adrenergic and dopaminergic signaling","description":"This cluster is dominated by GO terms for brain-centered adrenergic receptor signaling (MAPK- and PLC-activated pathways) and dopaminergic synaptic transmission, with supporting terms on vasoconstriction and brain renin-angiotensin signaling. Together, these indicate a cohesive theme of neuronal catecholamine signaling, despite a few outliers related to immune cells.","confidence":"High","size":9,"edges":29,"triangles":42,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":8},{"id":"GO:0001963","count":8},{"id":"GO:1900453","count":8},{"id":"GO:0001994","count":8},{"id":"GO:0071883","count":8}]},{"hash":"2279156481294450477","title":"Brain GPCR signaling: adrenergic and dopaminergic","description":"This cluster is dominated by GO terms related to neural GPCR signaling, including adrenergic receptor pathways (MAPK-activating and PLC-activating), dopaminergic synaptic transmission, and related neuromodulatory processes (e.g., norepinephrine/epinephrine effects on blood pressure). The presence of brain renin-angiotensin system terms further supports a brain-centered neuroendocrine signaling theme. Some immune-related terms and an obsolete term appear, likely reflecting annotation noise, but the core signal points to neural GPCR-mediated signaling and neurotransmission.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":6},{"id":"GO:0001963","count":6},{"id":"GO:1900453","count":6},{"id":"GO:0001994","count":6},{"id":"GO:0071883","count":6}]},{"hash":"965603610733234276","title":"Vascular inflammation and angiogenesis","description":"The top GO terms point to endothelial behavior (migration, sprouting, tight junctions) and ECM remodeling (collagen fibril organization), combined with immune-related processes (innate immune response, acute inflammatory response, immunological synapse formation, phagocytic clearance, endocytosis). This pattern suggests a module focused on endothelial-driven vascular remodeling during inflammation, coordinating immune interactions and angiogenic processes.","confidence":"High","size":9,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0010744","count":3},{"id":"GO:0043542","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0001771","count":3}]},{"hash":"1121793433867187257","title":"Brain adrenergic-dopaminergic signaling","description":"This cluster is dominated by GO terms linking brain-related signaling: dopaminergic synaptic transmission, brain renin-angiotensin system, and adrenergic receptor\u2013coupled pathways (MAPK, PLC, and cAMP signaling), all pointing to neural modulation of synaptic activity and vascular regulation. Some terms (thymocyte differentiation, neutrophil chemotaxis) seem peripheral or noisy, but the core theme is neural adrenergic/dopaminergic signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":4},{"id":"GO:0001963","count":4},{"id":"GO:1900453","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0071883","count":4}]},{"hash":"999133919690979712","title":"Synaptic and junctional protein localization","description":"The top GO terms cluster around localization of proteins to neural membrane domains and junctions, including protein/receptor localization to synapses, adherens junctions, and myelin sheath regions, suggesting a focus on spatial organization of proteins in neural cells. Phosphorylation and signaling terms are supportive rather than defining. ","confidence":"Medium","size":9,"edges":15,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":4},{"id":"GO:0046711","count":3},{"id":"GO:0045197","count":3},{"id":"GO:0006015","count":3},{"id":"GO:0097120","count":3}]},{"hash":"936920984995570542","title":"UV Damage Response and NER Repair","description":"GO terms show strong enrichment for UV response (UV-B/UV-C) and nucleotide-excision repair (pyrimidine dimer repair, transcription-coupled NER), indicating a DNA damage response pathway activated by UV exposure. Other terms like vacuolar acidification and proton transport appear peripheral, so the core theme is UV-induced DNA repair.","confidence":"High","size":9,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0007035","count":2},{"id":"GO:0010224","count":1},{"id":"GO:0040034","count":1},{"id":"GO:0000720","count":1}]},{"hash":"632429943048185547","title":"Ergothioneine and selenoneine biosynthesis","description":"The top GO terms are dominated by ergothioneine and selenoneine biosynthetic processes (e.g., ergothioneine biosynthesis from histidine via gamma-glutamyl-hercynylcysteine sulfoxide and selenoneine biosynthesis), suggesting the cluster centers on this biosynthetic pathway. Some other terms appear to be obsolete or unrelated, but the recurring biosynthesis terms provide a coherent theme.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:1903257","count":1},{"id":"GO:1903255","count":1},{"id":"GO:0052704","count":1},{"id":"GO:0052707","count":1}]},{"hash":"557280005230939096","title":"Hypoxia-driven angiogenesis and stress signaling","description":"This cluster's top GO terms cluster around hypoxia response and angiogenesis, with supporting signals from insulin/nutrient sensing (insulin stimulus, amino acid response), mitochondrial regulation (membrane potential) and survival-related processes (apoptosis, epithelial proliferation). The pattern suggests proteins involved in adapting to low oxygen while promoting growth and cellular survival, linking metabolic stress responses to angiogenic signaling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0032869","count":2}]},{"hash":"1646087108434515816","title":"Innate Immunity and Complement Activation","description":"Based on the most represented GO terms\u2014innate immune response and complement activation (classical pathway)\u2014the cluster appears to group proteins involved in innate immunity and immune signaling. Additional terms indicate cytokine regulation and B cell activation, supporting an immune-focused set. Some neural-related terms (synapse organization, axon guidance) and glomerular filtration appear, but these seem less central to the cluster\u2019s core function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":3},{"id":"GO:0097067","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0008045","count":3}]},{"hash":"723411692164185092","title":"Unknown","description":"The GO terms are heterogeneous, including membrane targeting/insertion, bitter taste detection, endosomal transport, telomere maintenance, development, dsRNA response, and DNA repair. There\u2019s no single cohesive function linking all nine proteins, so a unified label isn\u2019t apparent.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006612","count":2},{"id":"GO:0051205","count":2},{"id":"GO:0001580","count":2},{"id":"GO:2000009","count":1},{"id":"GO:0060400","count":1}]},{"hash":"923144099393873873","title":"Protein quality control and stress signaling","description":"The top GO terms cluster around protein modification and turnover (sumoylation, ubiquitin-dependent ERAD), autophagic/nuclear turnover (piecemeal microautophagy of the nucleus), and stress-responsive signaling (regulation of calcineurin-NFAT signaling; cardiac muscle hypertrophy in response to stress), along with cell-cycle control points (G1/S transition and DNA damage checkpoint). This pattern points to mechanisms that maintain proteome integrity and coordinate responses to cellular stress via degradation, modification, and signaling. A few terms (ascospore formation, lipid A biosynthetic process) are less clearly connected and may reflect cross-species annotations or noise. Overall, a cohesive theme is plausible, hence Medium confidence. ","confidence":"Medium","size":8,"edges":18,"triangles":16,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030437","count":3},{"id":"GO:0050774","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0034727","count":2},{"id":"GO:0016925","count":2}]},{"hash":"1186961865714386039","title":"Cell Cycle and DNA Replication","description":"The top GO terms point mainly to mitotic transitions (G1/S and G2/M), DNA replication, and mitotic checkpoint signaling, which together define a core cell cycle machinery theme. Peripheral terms related to development and signaling are present but less central, so a label centered on cell cycle processes best represents the cluster.","confidence":"High","size":8,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0000742","count":2},{"id":"GO:0000272","count":1}]},{"hash":"359097872572643312","title":"Cardiac muscle morphogenesis and contraction","description":"The top GO terms are dominated by heart-related processes: ventricular cardiac muscle tissue morphogenesis, cardiac muscle contraction, and regulation of muscle filament sliding speed, with additional terms about fiber-type transitions. This suggests the proteins cluster around cardiac muscle development and contractile regulation rather than a single other function. Some general terms (e.g., mitotic cell cycle, nuclear envelope organization) may reflect shared cellular machinery, but the principal theme is cardiac muscle differentiation and contraction.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0006998","count":3},{"id":"GO:0044319","count":3}]},{"hash":"831871976062170857","title":"Unknown","description":"The GO terms cover a wide range of disparate processes (protein ubiquitination, cell cycle, vitamin D response, telomere maintenance, endothelial changes, NOD2 signaling, IL-12 regulation, pain detection, growth, and muscle stretch response), with no clear shared function or theme linking the cluster members. This heterogeneity suggests no single, coherent biological function for the group. ","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":7},{"id":"GO:0007049","count":6},{"id":"GO:0033280","count":6},{"id":"GO:0032212","count":4},{"id":"GO:0097497","count":4}]},{"hash":"1082250390858232953","title":"Cell-cycle signaling and cytoskeletal regulation","description":"The top GO terms cluster around signaling and cytoskeletal dynamics (cellular response to TGF-beta, positive regulation of GTPase activity, barbed-end actin filament capping, and positive regulation of peptidyl-tyrosine phosphorylation) and also include mitotic cell cycle and regulation of cell cycle checkpoint, suggesting a functional theme of coordinating signaling with cytoskeletal changes and cell-cycle control. A few terms (chromatin organization, ubiquitin-dependent ERAD) point to broader nuclear regulation, and a taste perception term likely reflects annotation noise. Overall, this set appears to reflect proteins involved in signaling that governs cytoskeleton and cell-cycle processes rather than a single narrow function. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0050731","count":2},{"id":"GO:0030433","count":1}]},{"hash":"982096607695344651","title":"Calcium-dependent exocytosis and Rho signaling in development","description":"This cluster centers on GO terms for calcium ion-dependent exocytosis and Rho GTPase signaling, with multiple development-related terms across heart, nervous system, brain, and skeletal system development, suggesting a cohesive role in vesicle trafficking and signaling during development. The presence of vesicle fusion and GTPase activity reinforces a shared mechanism linking signaling to exocytosis in developing tissues.","confidence":"High","size":8,"edges":18,"triangles":17,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0045956","count":7},{"id":"GO:0007266","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0007420","count":7}]},{"hash":"1311784694201190147","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":7,"triangles":3,"max_degree":4,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0072715","count":7},{"id":"GO:2000616","count":7},{"id":"GO:0018144","count":7}]},{"hash":"258978664261214814","title":"ECM Remodeling and Developmental Cell Migration","description":"Top GO terms cluster around collagen fibril organization, slit diaphragm assembly, and angiogenesis, with additional signals for cell migration and synapse organization, including forebrain migration and vestibular morphogenesis. This pattern suggests a developmental program centered on extracellular matrix remodeling and cell adhesion guiding tissue morphogenesis and neural/vascular patterning.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":7},{"id":"GO:0060116","count":7},{"id":"GO:1904237","count":7},{"id":"GO:0055072","count":7},{"id":"GO:0050808","count":7}]},{"hash":"28541217819506423","title":"Chromatin and Cell Cycle Regulation","description":"The cluster centers on chromatin organization and mitotic/cell cycle processes (e.g., mitotic cell cycle, regulation of cell cycle checkpoint, chromatin organization, histone modification), with translation initiation and GTPase regulation providing broader regulatory context; a few terms appear as noise (taste perception, obsolete annotations).","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0030433","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0071560","count":3}]},{"hash":"1179897884685646224","title":"Embryonic Organ Morphogenesis","description":"Dominant theme is embryonic morphogenesis across multiple tissues (kidney development, lymphatic/vascular morphogenesis, cartilage condensation). Some immune and stress-related terms may reflect developmental context, but the core signals point to organogenesis processes rather than a single pathway.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":2},{"id":"GO:0038094","count":2},{"id":"GO:0072287","count":2},{"id":"GO:2000502","count":2},{"id":"GO:0071226","count":2}]},{"hash":"1889658414337617420","title":"Unknown","description":"The top GO terms cover a wide range of processes including immune signaling (response to lipopolysaccharide, T cell receptor signaling), development (kidney and vagina development), neurogenesis, circadian regulation, apoptosis, and broad gene expression regulation, with no single dominant function tying the proteins together. This diffuse mix suggests there isn\u2019t a cohesive, interpretable theme for this cluster.","confidence":"","size":8,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010628","count":6},{"id":"GO:0055091","count":5},{"id":"GO:0045187","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0060068","count":4}]},{"hash":"706069113771789901","title":"Cardiac valve development and cell adhesion","description":"The dominant GO terms are cell\u2013cell and cell\u2013matrix adhesion, plus cardiac development signals such as mitral valve formation and endocardial cushion formation, indicating a cohesive role in cardiac morphogenesis driven by adhesion processes. A few terms related to ossification and nephron differentiation appear but are peripheral to the primary heart-related theme. Thus the cluster represents cardiac valve morphogenesis coordinated by adhesion.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":5},{"id":"GO:0043931","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0034392","count":4},{"id":"GO:0007156","count":3}]},{"hash":"77077586762176489","title":"Neuronal signaling and dendrite morphogenesis","description":"The top GO terms point to neural-related processes (visual perception and dendrite morphogenesis) alongside signaling and phosphorylation pathways (ERK cascade, GTPase activity, peptidyl-serine phosphorylation). Although some terms are less informative, the cluster appears to group proteins involved in neuronal signaling and dendritic development, with overlaps in apoptosis as part of cell fate during remodeling. Confidence: Medium","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0032092","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0048813","count":3}]},{"hash":"1680727304527835834","title":"Developmental morphogenesis and cell migration","description":"Many terms point to developmental patterning and tissue formation (collagen fibril organization, forebrain cell migration, vestibular receptor morphogenesis, salivary gland boundary specification, slit diaphragm assembly, angiogenesis) and to ECM-mediated cell adhesion and movement (positive regulation of substrate-dependent cell migration, synapse organization). These collectively suggest a theme of developmental tissue morphogenesis governed by ECM remodeling and cell migration. Obsolete terms related to iron homeostasis and tau kinase were ignored in forming the label.","confidence":"Medium","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":5},{"id":"GO:0060116","count":5},{"id":"GO:1904237","count":5},{"id":"GO:0055072","count":5},{"id":"GO:0050808","count":5}]},{"hash":"1840034212805400515","title":"Diverse tissue development and differentiation","description":"The top GO terms point to multiple tissue-specific developmental processes (myoblast fate, branchiomeric muscle development, oligodendrocyte and nerve development, inner ear differentiation, kidney morphogenesis, mast cell migration) along with general transcription by RNA polymerase II, suggesting a broad theme of transcriptional programs driving diverse tissue specification rather than a single pathway. Some terms (humoral immune response) are peripheral or potentially annotation noise, but do not define a single cohesive function. Confidence: Medium","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0007518","count":5},{"id":"GO:0006959","count":5},{"id":"GO:0042491","count":5},{"id":"GO:0072282","count":5}]},{"hash":"1708734216436294266","title":"Unknown","description":"The Top Terms are highly diverse, spanning neural/behavioral processes (prepulse inhibition, startle response, ethanol response) and metabolic/immune/developmental terms (insulin signaling, triglyceride catabolism, T cell migration, genital morphogenesis), with no clear single theme tying them together. This lack of a coherent functional edge suggests no specific, representative cluster function can be assigned.","confidence":"","size":8,"edges":8,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0060134","count":3},{"id":"GO:0045471","count":3},{"id":"GO:0001964","count":3},{"id":"GO:0006915","count":3}]},{"hash":"813676084075504263","title":"ER-Golgi vesicle trafficking","description":"This cluster is enriched for vesicle fusion and trafficking terms between the ER and Golgi (GO:0048279, GO:0016320, GO:0048280), indicating involvement in the intracellular secretory pathway. Additional terms on lipoprotein metabolism and lipid transport align with secretory/endocrine roles that rely on vesicle trafficking, while some differentiation and receptor internalization terms suggest broader trafficking involvement across cell types. Overall, the dominant theme is ER-Golgi vesicle trafficking with supporting secretory and lipid-handling functions.","confidence":"Medium","size":8,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048279","count":2},{"id":"GO:0016320","count":2},{"id":"GO:0048280","count":2},{"id":"GO:0035987","count":1},{"id":"GO:0042157","count":1}]},{"hash":"1142104009803271619","title":"Drosophila Oogenesis Ub-Dependent Trafficking","description":"Top GO terms strongly point to egg chamber formation and follicle cell dynamics in the Drosophila germarium, indicating an oogenesis-related function. Several terms also highlight ubiquitin-dependent endocytosis and MVB-mediated protein sorting, suggesting a role for ubiquitin-dependent trafficking during oogenesis. This combination supports a coherent theme of Drosophila egg chamber development coupled with Ub-mediated protein sorting and degradation.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0032147","count":1},{"id":"GO:0006612","count":1},{"id":"GO:0030713","count":1},{"id":"GO:0044130","count":1}]},{"hash":"1340714181611306028","title":"Steroid hormone and prostaglandin lipid metabolism","description":"The top GO terms cluster around steroid hormone biosynthesis/metabolism (androgen, progesterone, aldosterone) and prostaglandin biosynthesis, with additional indication of omega-hydroxylase P450 pathways. This points to a lipid-derived hormone metabolism theme. Some terms relate to vascular development and stress responses, but the dominant signal is lipid hormone metabolism, supporting a cohesive interpretation as a steroid and prostaglandin lipid metabolism module.","confidence":"Medium","size":8,"edges":8,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":2},{"id":"GO:0097267","count":2},{"id":"GO:0033076","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0035902","count":2}]},{"hash":"1038549633710952032","title":"ECM Remodeling and Adhesion Signaling","description":"The top GO terms cluster around extracellular matrix disassembly and cadherin-mediated cell adhesion, with associated signaling via PKC and broader membrane/lipid localization. Podocyte development hints kidney-specific contexts where ECM interactions and adhesion are crucial. While other terms touch on mitochondria or innate immunity, the core theme points to ECM remodeling coupled with adhesion signaling. Confidence: Medium","confidence":"","size":8,"edges":10,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0010918","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0010876","count":2}]},{"hash":"2285891248770173874","title":"Ubiquitin-dependent proteolysis and TNF/JNK signaling","description":"The top terms cluster around ubiquitin-dependent protein catabolic processes (ERAD, autoubiquitination) and signaling pathways initiated by TNF, including regulation of the JNK cascade. This suggests a shared theme of protein turnover via ubiquitination linked to inflammatory signaling, with some receptor-related catabolic processes, justifying the label.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0033209","count":3},{"id":"GO:0051865","count":3}]},{"hash":"1634752077822862171","title":"Lipid metabolism and neuromuscular signaling","description":"The cluster shows enrichment for lipid droplet organization and adipose tissue development, suggesting a lipometabolic emphasis. It also includes neuromuscular process and negative regulation of synaptic assembly at the neuromuscular junction, pointing to neuromuscular signaling involvement. Additional terms touching mitochondrial membrane potential and peroxisome inheritance imply broader organelle dynamics linked to metabolism, though a few terms (e.g., BMP signaling, abscission) are less central to the core theme.","confidence":"Medium","size":8,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0009838","count":2},{"id":"GO:0034389","count":2},{"id":"GO:0030514","count":2},{"id":"GO:0051881","count":2},{"id":"GO:0045033","count":2}]},{"hash":"602061004814586093","title":"Regulation of intracellular signaling and apoptosis","description":"This cluster mixes GO terms tied to modulation of key signaling pathways (Rho, Ras, PI signaling) and apoptotic regulation, with additional terms on neural activity (glutamatergic transmission, synaptic plasticity) and immune/vascular processes (hemopoiesis, blood vessel remodeling, neutrophil degranulation). The common thread is regulation of signaling and cell survival across diverse cell types, though the context is broad rather than single-taceted, so a Medium confidence is appropriate.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0030097","count":3},{"id":"GO:0060304","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0034351","count":2}]},{"hash":"54921386082779784","title":"RNA processing and protein translation","description":"This cluster is strongly enriched for translation-related terms (cytoplasmic and mitochondrial translation, translation processes) and rRNA maturation, plus RNA folding and splicing regulation, pointing to a coordinated set of proteins involved in RNA processing and protein synthesis. Minor signals like response to antibiotic or nerve growth factor are less central. Overall, the core theme is RNA maturation alongside protein synthesis machinery.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":2},{"id":"GO:0033120","count":1},{"id":"GO:0000372","count":1},{"id":"GO:0006450","count":1}]},{"hash":"1014980057107249407","title":"Neuronal axon guidance and signaling","description":"Top terms cluster around axon extension and guidance (corticospinal and retinal neurons) with related signaling and extracellular matrix interactions, plus stress- and environment-responsive signals (cortisol, mechanical stimulus, NF-kappaB) that collectively point to neural connectivity formation and axon pathfinding.","confidence":"High","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048846","count":6},{"id":"GO:0019800","count":5},{"id":"GO:0050929","count":5},{"id":"GO:0090260","count":5},{"id":"GO:0051414","count":5}]},{"hash":"1508937798510684918","title":"Neurovascular development and signaling","description":"This cluster groups proteins tied to neural signaling (neurotransmitter secretion, receptor clustering, cerebellar granule cell precursor proliferation) and vascular differentiation (Notch signaling in arterial endothelial fate, endothelial tip cell fate), suggesting a neurovascular development theme. Some terms like bone mineralization and grooming behavior are less directly linked, indicating possible annotation noise or pleiotropy, but the core signal points to neural-vascular development.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007269","count":6},{"id":"GO:0043113","count":6},{"id":"GO:2000821","count":6},{"id":"GO:0030282","count":5},{"id":"GO:0032495","count":5}]},{"hash":"867373364322578522","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster\u2019s top terms are dominated by ubiquitination-related processes (autoubiquitination, K48-linked ubiquitination, ubiquitin-dependent protein catabolic process), indicating proteins involved in tagging substrates for proteasomal degradation. A histone catabolic process term also appears, suggesting turnover of chromatin components via ubiquitin pathways. Overall, this cluster seems focused on ubiquitin-mediated protein turnover.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":6},{"id":"GO:1903265","count":4},{"id":"GO:0085020","count":4},{"id":"GO:0036205","count":4},{"id":"GO:0042787","count":4}]},{"hash":"1531774371845852933","title":"Ribosome biogenesis and translation","description":"The top GO terms are dominated by ribosome-related processes: translation, ribosomal large subunit assembly and biogenesis, cytoplasmic translation, translational termination, and export of the large subunit from the nucleus. A single mitochondrial translation term is present but not central. Together these indicate a cluster of proteins involved in ribosome construction and protein synthesis, justifying this label.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0000027","count":3},{"id":"GO:0015968","count":2},{"id":"GO:0006415","count":2},{"id":"GO:0070126","count":1}]},{"hash":"1757669117436989543","title":"Vertebrate morphogenesis and adhesion","description":"The terms cluster around tissue development and morphogenesis: cartilage condensation, mesonephric duct development, and distal tubule morphogenesis, plus cell-matrix adhesion. While some items relate to signaling or immune pathways and behavior, the dominant theme is vertebrate development and tissue organization, so this label reflects the core function of the cluster.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":3,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0007160","count":4},{"id":"GO:0051006","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0001502","count":4},{"id":"GO:0071625","count":4}]},{"hash":"1809643953513509940","title":"LPS core and exopolysaccharide biosynthesis","description":"The top GO terms cluster around lipopolysaccharide core region biosynthesis, LPS biosynthesis, colanic acid, and sugar precursor pathways (ADP-L-glycero-manno-heptose, dTDP-rhamnose), indicating proteins mainly participate in bacterial cell envelope polysaccharide assembly; a minor PHB biosynthesis signal is present but secondary.","confidence":"High","size":8,"edges":8,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0009244","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0009242","count":2},{"id":"GO:0009103","count":2}]},{"hash":"1653065300884985811","title":"Immune signaling and antiviral responses","description":"The proteins are enriched for immune-related GO terms, including innate immune response, cellular response to virus, B cell receptor signaling, and negative regulation of viral genome replication, suggesting a core theme of immune signaling and antiviral defense. Additional terms such as regulation of translational initiation, mRNA processing, and response to toxic substances may reflect stress responses in immune cells. The absence of detected edges indicates these proteins may participate in multiple immune-related functions rather than a single cohesive module.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042997","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0008285","count":2}]},{"hash":"1668141933103616904","title":"Unknown","description":"The top GO terms span animal muscle development, plant cell wall biogenesis, starch biosynthesis, and various stress responses, with several obsolete terms. This mixture provides no single coherent function or pathway across the proteins, so a meaningful, specific label cannot be assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":2},{"id":"GO:0009832","count":1},{"id":"GO:0019252","count":1},{"id":"GO:0010555","count":1},{"id":"GO:0009405","count":1}]},{"hash":"266465610740562025","title":"Cytokine-driven immune signaling and transcription","description":"This cluster predominantly features GO terms tied to immune responses and signaling triggered by cytokines and stimuli (TGF-beta, LPS, GM-CSF) and pathways like T cell receptor signaling, along with DNA-templated transcription, suggesting coordinated immune signaling and stimulus-induced gene expression. Some terms (mitotic cell cycle, visual perception, cell wall organization) appear tangential, likely reflecting broader annotations of the proteins rather than core functions.","confidence":"Medium","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0046827","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0071222","count":4},{"id":"GO:0006351","count":4}]},{"hash":"1175236322731599699","title":"Unknown","description":"The GO terms are highly diverse, spanning surfactant homeostasis, memory, basement membrane remodeling, thyroid hormone response, bone resorption, ossification, lung branching, and T cell cytotoxicity, with several obsolete terms. There is no clear shared function or pathway tying these proteins together, and the cluster has no edges or cohesive connectivity to suggest a common theme. Therefore a single cohesive label cannot be assigned; Unknown is appropriate.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043129","count":1},{"id":"GO:0007614","count":1},{"id":"GO:0034769","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0097067","count":1}]},{"hash":"748158648949283122","title":"Epigenetic Regulation and Differentiation","description":"The top GO terms point to epigenetic control (histone deacetylation, methylation) and various differentiation processes (granulocyte and erythrocyte differentiation, gastrulation), as well as proliferation regulation. While there are some outliers (xenobiotic response, tRNA modification, aging), the strongest shared theme is epigenetic regulation guiding cell fate and development, making this label representative for the cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016575","count":2},{"id":"GO:0030851","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0002098","count":2}]},{"hash":"341723611640192892","title":"Leukocyte chemotaxis and integrin activation","description":"The cluster shows enrichment for leukocyte/macrophage chemotaxis, positive regulation of protein tyrosine kinase activity, and integrin activation, pointing to a module governing immune cell recruitment and adhesion through tyrosine kinase\u2013driven signaling. Additional terms such as T cell chemotaxis, TNF production regulation, and lipid stimulus responses support an inflammation-related migration/adhesion program.","confidence":"High","size":8,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0050918","count":2},{"id":"GO:0061098","count":2},{"id":"GO:0048246","count":2},{"id":"GO:0050902","count":1},{"id":"GO:0033625","count":1}]},{"hash":"1247428757852722518","title":"Mitosis and Protein Folding","description":"The cluster shows a strong enrichment for mitosis-related terms (mitotic cell cycle, cell division, anaphase-promoting complex\u2013dependent catabolic process), indicating a core involvement in cell cycle progression. It also includes protein folding and proteostasis-related terms (peptidyl-prolyl isomerization, response to unfolded protein), suggesting a coupling of protein quality control with mitosis. Some terms (interferon response, chlorophyll biosynthesis, fat pad development) appear less related and may reflect annotation noise. Overall, the dominant theme is mitotic progression with proteostasis.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:1903646","count":3},{"id":"GO:0000413","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:2000324","count":3}]},{"hash":"1389232556217524727","title":"Proteostasis via ubiquitin-proteasome system","description":"The dominant GO terms are proteasome regulatory particle assembly and protein ubiquitination, with related ubiquitin-dependent ERAD and protein processing terms, pointing to protein quality control and degradation as the core function of this cluster. Other terms like mRNA export, vesicle transport, cilium movement, and replication-related processes are present but appear secondary, likely reflecting broader cellular context rather than the main theme.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070682","count":6},{"id":"GO:0016567","count":5},{"id":"GO:0048219","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0016485","count":4}]},{"hash":"264537347800631525","title":"Hair Keratinization","description":"The top GO terms are keratinization and hair cycle, which together point to proteins involved in hair follicle structure and the keratinization process during hair growth. This cluster likely represents a keratin/structural filament module specific to hair, reflecting hair follicle biology rather than general cellular processes.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":8},{"id":"GO:0042633","count":8}]},{"hash":"2061396034308187417","title":"Glutamine/glutamate and folate metabolism with proteolysis","description":"The cluster shows enrichment for amino acid metabolism (L-glutamine, L-glutamate) and folate metabolism (tetrahydrofolylpolyglutamate), plus proteolysis, suggesting roles in core metabolic pathways and protein turnover. Additional terms like response to zinc ion, ethanol, and insulin imply environmental and hormonal regulation of these processes, supporting a cohesive theme of metabolism-linked proteolysis and stress signaling.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0046900","count":2},{"id":"GO:0006541","count":2},{"id":"GO:0010043","count":2},{"id":"GO:0045471","count":2}]},{"hash":"862040934822521997","title":"Unknown","description":"The GO terms are highly diverse, including immune signaling (T cell proliferation and costimulation), muscle differentiation, apoptosis (cytochrome c release), DNA repair, sex-determination in germ lines, TGF-beta signaling, and photosystem adjustment. There is no clear, single biological function tying these proteins together, so a cohesive label is not apparent.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042102","count":2},{"id":"GO:0010693","count":2},{"id":"GO:0045663","count":2},{"id":"GO:0031295","count":2},{"id":"GO:0090200","count":2}]},{"hash":"578619634434089292","title":"Cell-surface glycosylation and glycoprotein biosynthesis","description":"The cluster is dominated by GO terms related to glycosylation, including carbohydrate metabolism, glycosphingolipid biosynthesis, and arabinogalactan protein metabolism, all pointing to formation and modification of cell-surface glycans and glycoproteins. A few terms touch on related processes like epithelial polarity and insect development, but the core theme centers on glycosylation pathways that decorate the cell surface.","confidence":"Medium","size":8,"edges":9,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0033580","count":2},{"id":"GO:0005975","count":2},{"id":"GO:0030259","count":2},{"id":"GO:0006688","count":2},{"id":"GO:0001744","count":1}]},{"hash":"204998018080242701","title":"Unknown","description":"The Top Terms include both core protein synthesis (ribosome biogenesis and translation) and a broad mix of signaling, development, and immune-related processes (thymic T cell selection, cell-substrate adhesion, osteoblast differentiation, neutrophil chemotaxis, pancreatic cell proliferation, smooth muscle proliferation, hair follicle development). There is no coherent single function linking all terms, so a specific, representative label cannot be determined.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0045060","count":1},{"id":"GO:0010811","count":1},{"id":"GO:0001649","count":1}]},{"hash":"1063616510175008202","title":"Cholesterol Transport and Lipid Homeostasis","description":"The cluster\u2019s top GO terms cluster around lipid metabolism and cholesterol handling: reverse cholesterol transport, triglyceride homeostasis, LDL particle\u2013mediated signaling, phospholipid catabolism, and macrophage foam cell differentiation. While a couple of terms reflect stress responses (xenobiotic/toxic stimuli), the dominant theme is cholesterol transport and lipid homeostasis, suggesting the proteins work together in lipid processing and lipoprotein signaling. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0044179","count":2}]},{"hash":"1073969984288882333","title":"Acrosome formation and spermatid differentiation","description":"The cluster is dominated by terms related to sperm development, notably acrosome assembly and spermatid nucleus differentiation, plus exocytosis and cytoskeleton-regulating GTPase/Rac signaling, which together point to spermatogenesis and acrosome-related processes. A single outlier term about mammary gland epithelial cell proliferation is likely incidental. ","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030037","count":4},{"id":"GO:0033601","count":4},{"id":"GO:0001675","count":4},{"id":"GO:1902647","count":4},{"id":"GO:0043547","count":4}]},{"hash":"789120973480620444","title":"Cardiac hypertrophy signaling and calcium handling","description":"The top GO terms cluster around cardiac muscle hypertrophy in response to stress, including positive regulation of hypertrophy and regulation of the calcineurin-NFAT signaling cascade, as well as calcium ion transport and mitochondrial calcium regulation. This points to a shared function in cardiac stress signaling and calcium-dependent remodeling. Some terms (e.g., mitotic cell cycle, polysaccharide catabolic process) appear less central to cardiac stress, likely representing secondary associations within the protein set. Overall, the dominant theme is hypertrophy signaling in the heart with calcium signaling involvement.","confidence":"Medium","size":7,"edges":15,"triangles":12,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903244","count":6},{"id":"GO:0000272","count":5},{"id":"GO:0014898","count":5},{"id":"GO:0051531","count":5},{"id":"GO:0042554","count":5}]},{"hash":"1477962271847422571","title":"Actin Dynamics in Mitosis and Mitochondrial Inheritance","description":"The cluster shows strong representation of actin-related processes (actin polymerization, postsynaptic actin organization, actomyosin ring assembly) and mitotic events (mitotic cytokinesis), plus terms for mitochondrion localization and inheritance, suggesting coordinated actin remodeling during cell division and mitochondrial distribution.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":5},{"id":"GO:0000001","count":5},{"id":"GO:0043486","count":5},{"id":"GO:0016344","count":5},{"id":"GO:0098974","count":5}]},{"hash":"1057212875763312613","title":"Hearing-related neural signaling and heart development","description":"The top GO terms point to neural signaling and sensory function, especially GABAergic synaptic transmission and sensory perception of sound, suggesting a cluster centered on neural/auditory processes. Additional terms indicate developmental and adhesion roles (integrin activation and heart development), implying a link between neural signaling and morphogenesis. Some metabolic/ion transport terms are present but do not define the core theme, so the label emphasizes hearing-related neural activity plus heart development as the main common thread.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0010765","count":7},{"id":"GO:0010925","count":6},{"id":"GO:1904140","count":6},{"id":"GO:1904261","count":6},{"id":"GO:0032000","count":6}]},{"hash":"210638951749993064","title":"Ubiquitin-mediated proteostasis and autophagy","description":"This cluster is dominated by GO terms tied to ubiquitin-dependent ERAD, and protein autoubiquitination, highlighting a core role in protein quality control. The presence of mitophagy reinforces a theme of selective degradation and turnover, while additional terms related to signaling and transcription may reflect broader regulatory roles. Overall, the strongest common thread is ubiquitin-mediated proteostasis and autophagy.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0051865","count":6},{"id":"GO:1903265","count":6},{"id":"GO:1901340","count":6},{"id":"GO:1904049","count":6}]},{"hash":"1182918687679039174","title":"Telomere maintenance and PARP signaling","description":"The top GO terms are dominated by telomere maintenance and regulation (telomerase regulation, telomere capping, telomere length regulation) and ADP-ribosylation processes (poly- and auto-ADP-ribosylation). This points to a shared function in telomere biology and PARP-mediated modification; other terms like Wnt signaling or synaptic regulation are present but less central, making the telomere/PARP theme the strongest signal.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":4},{"id":"GO:0070212","count":4},{"id":"GO:1904355","count":4},{"id":"GO:1900383","count":4},{"id":"GO:1904357","count":4}]},{"hash":"625234848900360589","title":"Angiogenesis and vascular remodeling","description":"This cluster centers on vascular development processes: angiogenesis and epithelium/morphogenesis, reinforced by extracellular matrix (collagen fibril organization) and signaling that governs smooth muscle proliferation, nitric oxide production, calcium signaling, and platelet regulation. These together point to coordinated vascular formation and remodeling rather than a single isolated function.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014067","count":3},{"id":"GO:0000338","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0002009","count":2}]},{"hash":"654001988304443110","title":"Imaginal Disc Growth and Cell Cycle","description":"The terms point to development and proliferation in insect imaginal discs (eye-antennal disc development; positive regulation of imaginal disc growth; cell cycle; cell division; cell population proliferation) alongside core nuclear processes (nucleolus organization; DNA-templated transcription). This suggests a cluster of proteins involved in disc development and concomitant cell-cycle regulation during organogenesis, with some ancillary terms like sepal formation reflecting broader developmental themes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007000","count":2},{"id":"GO:0035214","count":2},{"id":"GO:0045572","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0008283","count":2}]},{"hash":"1806563734914723894","title":"Immune Activation and dsRNA Response","description":"This cluster is driven by GO terms tied to immune signaling and antiviral/antibacterial responses, including response to exogenous dsRNA, interferon production, LPS signaling, and immunoglobulin-mediated response, as well as ubiquitin-dependent protein catabolic processes and proteasome-related roles that underpin antigen processing. A couple of outlier terms (e.g., chlorophyll biosynthesis) are likely noise, but the dominant themes point to immune activation and signaling.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006511","count":2},{"id":"GO:0043330","count":2},{"id":"GO:0032729","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0016064","count":2}]},{"hash":"2253190881667199666","title":"Unknown","description":"The terms are highly diverse (membrane transport, cytoskeletal assembly, nuclear import, neural development, centriole cohesion, plant hormone response, obsolete Wnt-related EMT, organ identity maintenance, chromatin transcription maintenance, and GTPase regulation) with no clear shared function or pathway linking all proteins, so there isn\u2019t a coherent theme to name the cluster beyond Unknown.","confidence":"","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":4},{"id":"GO:0045110","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0061380","count":3},{"id":"GO:0030997","count":3}]},{"hash":"1545561537984445191","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034476","count":5},{"id":"GO:0006306","count":5},{"id":"GO:1903241","count":5},{"id":"GO:0009432","count":5},{"id":"GO:0010501","count":5}]},{"hash":"2140423801999019425","title":"Actin-driven protrusions and adhesion","description":"The top GO terms center on actin-based membrane protrusions (filopodium and microspike assembly), regulation of Rho signaling, membrane invagination, and cell adhesion, pointing to coordinated cytoskeletal remodeling and cell\u2013substrate or cell\u2013cell interactions. Some obsolete terms appear but the dominant signal reflects actin dynamics and adhesion processes.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0010324","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1026678189436655319","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning proteostasis (proteasome assembly, ubiquitin-dependent protein catabolic process) as well as plant-specific development (chlorophyll biosynthetic process, stamen formation) and animal adhesion/immune signaling (cell-cell adhesion, integrin signaling, extravasation, T cell activation). This lack of a cohesive, single biological theme makes it hard to assign a precise, representative function to the cluster. Confidence: None","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":6},{"id":"GO:0015995","count":6},{"id":"GO:0006511","count":6},{"id":"GO:0048455","count":6},{"id":"GO:0003429","count":4}]},{"hash":"1219718734287432800","title":"Multiorgan morphogenesis and development","description":"The top GO terms cluster around developmental morphogenesis and organ formation across multiple tissues (brain, kidney, skin/hair, endoderm), with supporting terms like extracellular matrix disassembly and apoptotic cell clearance, indicating a general role in tissue remodeling during development rather than a single tissue-specific function.","confidence":"High","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":3},{"id":"GO:0043652","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0048854","count":3},{"id":"GO:0048496","count":3}]},{"hash":"1196898785248973571","title":"Plant cell wall glycosylation and biosynthesis","description":"The top GO terms are dominated by plant-specific cell wall biosynthetic processes (mucilage, glucuronoxylan, homogalacturonan, plant-type secondary cell wall biogenesis) and protein O-linked glycosylation, pointing to roles in assembling and glycosylating cell wall polysaccharides in plants; a few outliers (e.g., skeletal muscle regeneration) are likely noise. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016266","count":4},{"id":"GO:0071555","count":4},{"id":"GO:0010192","count":3},{"id":"GO:0006012","count":3},{"id":"GO:0035269","count":3}]},{"hash":"1768539944988476627","title":"Developmental signaling and vesicle trafficking","description":"The cluster shows multiple development-related GO terms spanning nervous/brain, heart, and skeletal development, plus processes related to vesicle fusion and regulation of GTPases. This points to a common theme of developmental signaling intertwined with vesicle trafficking and Rho/GTPase activity, rather than a single tissue-specific function.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045956","count":7},{"id":"GO:0007266","count":7},{"id":"GO:0007507","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0007420","count":7}]},{"hash":"1510324019365612262","title":"Cytoskeletal remodeling and cell migration","description":"The top GO terms are dominated by cytoskeletal and migratory processes: filopodium assembly, stress fiber assembly, neutrophil chemotaxis, positive regulation of cell spreading, and fibroblast migration. These indicate dynamic actin reorganization and adhesion changes that drive cell movement and shape changes. Some terms also relate to broader development and morphogenesis (pericardium morphogenesis, epiboly) and neural differentiation (myelination in PNS), which can involve substantial cytoskeletal remodeling. Together, these suggest a cluster of proteins involved in cytoskeletal dynamics enabling migration and morphogenesis across contexts.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0003344","count":5},{"id":"GO:0030593","count":5},{"id":"GO:1900026","count":5},{"id":"GO:0022011","count":4},{"id":"GO:0055113","count":4}]},{"hash":"93714955084616872","title":"ER Proteostasis and Protein Quality Control","description":"This cluster centers on ubiquitin-proteasome\u2013mediated protein quality control, ER-associated degradation, and translation regulation in response to ER stress and heat, indicating a coordinated proteostasis program in the secretory pathway.","confidence":"High","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071630","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0006452","count":6},{"id":"GO:0070389","count":6},{"id":"GO:0009408","count":6}]},{"hash":"644688990970936338","title":"Ubiquitination and ERAD-Mediated Proteostasis","description":"The GO terms are dominated by ubiquitin-related processes (protein ubiquitination, deubiquitination, sumoylation, autoubiquitination) and ER-associated degradation, along with regulation of proteasomal protein catabolic activity. This points to a core role in protein quality control and proteostasis via the ubiquitin-proteasome system and ERAD; a ribosomal subunit assembly term appears incidental. Overall, the cluster seems centered on ubiquitin-driven proteostasis mechanisms.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":7},{"id":"GO:0016579","count":7},{"id":"GO:0000028","count":7},{"id":"GO:0016925","count":7},{"id":"GO:1901799","count":7}]},{"hash":"1620677102058741827","title":"Integrin Signaling and Cytoskeletal Regulation","description":"Based on the enrichment of GO terms related to integrin-mediated signaling, actin filament capping, GTPase activity regulation, and cellular junction assembly, the cluster appears to center on adhesion-related signal transduction coupled to cytoskeletal remodeling. While some terms touch on broader or distinct processes (TGF-beta response, IL-2 production, vacuolar localization), the strongest cohesive theme is adhesion signaling intersecting with cytoskeletal dynamics and small GTPase regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0051016","count":3},{"id":"GO:0050731","count":3}]},{"hash":"767307551845901231","title":"Translation initiation and mRNA transport cluster","description":"The dominant GO terms point to translation initiation steps (formation of the preinitiation complex, translation reinitiation) and mRNA transport, suggesting a module centered on RNA handling and the start of protein synthesis. Additional signals reference kinase signaling and hypoxia response, which can influence translational control and cell growth, but the core theme is translation initiation and mRNA trafficking.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0031954","count":4}]},{"hash":"361385877835797030","title":"DNA Repair and Translesion Synthesis","description":"The GO terms cluster around DNA damage repair (NER, gap filling), UV-C\u2013induced damage response, DNA-templated replication, and both error-free and error-prone translesion synthesis, with supporting DNA biosynthesis. This combines genome maintenance, damage signaling, and lesion bypass during replication\u2014i.e., a DNA repair and damage-response module.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006281","count":3},{"id":"GO:0006261","count":3},{"id":"GO:0071494","count":2},{"id":"GO:0006297","count":2},{"id":"GO:0070987","count":2}]},{"hash":"1031830789133927198","title":"Ubiquitin-Dependent Protein Processing and Peroxisome Import","description":"The cluster is driven by strong signals for ubiquitination and ubiquitin-mediated processes (protein ubiquitination; ubiquitin-dependent ERAD pathway; deubiquitination) and peroxisome matrix import, suggesting a common theme of ubiquitin-regulated protein fate and peroxisomal targeting. Other terms like RNA splicing and circadian clock regulation may reflect broader roles of ubiquitin signaling but are less central. Overall, the strongest link is ubiquitin cycling and peroxisome protein import.","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0016558","count":3},{"id":"GO:0071600","count":2}]},{"hash":"1180564045123051808","title":"RNA Pol II Transcription Regulation","description":"These terms cluster around transcription by RNA polymerase II\u2014initiation, elongation, promoter clearance, start-site selection, and mRNA capping\u2014indicating a group of proteins involved in RNAP II transcription machinery or its regulation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010467","count":1},{"id":"GO:0060261","count":1},{"id":"GO:0042795","count":1},{"id":"GO:0050434","count":1},{"id":"GO:0032968","count":1}]},{"hash":"1720235839944519861","title":"Cell adhesion and intercellular signaling","description":"This cluster is enriched for GO terms related to cell-cell adhesion (homophilic adhesion, intermicrovillar adhesion) and barrier/ junctional functions (endothelial barrier establishment), as well as signaling at specialized junctions (PSD-95 clustering, synaptic-like organization). While some terms touch on tissue-specific processes (melanosome transport, B cell differentiation), the common theme appears to be intercellular communication and maintenance of cell junctions across various tissues, justifying a label focused on adhesion and signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":3},{"id":"GO:0032912","count":3},{"id":"GO:0086073","count":3},{"id":"GO:1903142","count":3},{"id":"GO:0007156","count":3}]},{"hash":"465305595667571097","title":"Unknown","description":"The top terms are highly diverse, spanning vertebrate development (angiogenesis, cardiac neural crest\u2013related heart development, visual perception) and non-developmental processes (biofilm formation, filamentous growth, dsRNA and muramyl dipeptide responses, spindle assembly, apoptosis regulation). There isn\u2019t a single cohesive function or pathway that ties these proteins together, so a clear, intuitive cluster label isn\u2019t supported.","confidence":"","size":7,"edges":5,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":7},{"id":"GO:0090606","count":7},{"id":"GO:0061308","count":7},{"id":"GO:0001525","count":7},{"id":"GO:0043330","count":7}]},{"hash":"1460449430572762618","title":"Epithelial Polarity and Cytoskeletal Dynamics","description":"This cluster is dominated by GO terms for establishing epithelial cell polarity, cell migration, and actin filament bundle assembly, pointing to coordinated polarity and cytoskeleton-driven motility. Endothelial delamination and vascular-related terms support tissue remodeling contexts, while several other terms appear less central and may reflect pleiotropy; overall the core signal centers on polarity and cytoskeleton dynamics.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090162","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0051017","count":3},{"id":"GO:0032212","count":2},{"id":"GO:0097497","count":2}]},{"hash":"1006765397866431790","title":"Skeletal muscle Ca2+ handling and T-tubule organization","description":"The top GO terms show clear muscle-specific functions: T-tubule organization, involuntary skeletal muscle contraction, and calcium ion import into the sarcoplasmic reticulum, all pointing to excitation-contraction coupling and Ca2+ handling in skeletal muscle. Additional membrane transport terms (potassium and proton transport) support the idea of coordinated ion movement across muscle cell membranes, while tRNA/rRNA processing likely reflects general cellular maintenance. Overall, these terms converge on muscle calcium handling and structural organization. ","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":2},{"id":"GO:0006364","count":2},{"id":"GO:1903416","count":2},{"id":"GO:0016311","count":2},{"id":"GO:0033292","count":2}]},{"hash":"2101070192216898491","title":"Cell adhesion and tissue organization","description":"The leading GO terms emphasize cell-cell adhesion and junctions (homophilic adhesion, intermicrovillar adhesion, endothelial barrier establishment, and myocyte adhesion), with supporting signals related to microvilli/tissue organization. While a few terms (melanosome transport, germinal center B cell differentiation, PSD95 clustering) seem peripheral, the core pattern points to adhesion and maintenance of tissue integrity across cell types.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":2},{"id":"GO:0032912","count":2},{"id":"GO:0086073","count":2},{"id":"GO:1903142","count":2},{"id":"GO:0007156","count":2}]},{"hash":"879975092269769476","title":"Cell Cycle and Chromatin Regulation","description":"The top GO terms cluster around growth signaling and cell division (TORC1 signaling, regulation of cell cycle checkpoints, mitotic cell cycle) together with chromatin-related processes (chromatin organization, histone acetylation). This suggests a group of proteins coordinating nutrient/growth signals with replication/mitosis and transcriptional control. Some terms appear less relevant or obsolete (e.g., ERAD pathway, taste perception), but the dominant theme points to cell-cycle progression linked to chromatin regulation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":3},{"id":"GO:0031954","count":3},{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0071560","count":2}]},{"hash":"1252939715245406951","title":"Unknown","description":"The top GO terms span ribosome biogenesis, immune signaling, sensory perception, neural development, synaptic assembly, stress and yeast responses, and TORC1 signaling, with no clear shared function linking these terms. The cluster appears functionally heterogeneous rather than cohesive, so a single interpretive label is not warranted.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0090594","count":1},{"id":"GO:1900042","count":1},{"id":"GO:0050909","count":1},{"id":"GO:0035156","count":1}]},{"hash":"1621739883915983759","title":"ECM remodeling and fibroblast migration","description":"The strongest signals are cell migration and fibroblast migration, plus hyaluronan metabolic process, which point to extracellular matrix (ECM) remodeling guiding cell movement. Additional terms like VEGF response and GM-CSF stimulus suggest tissue remodeling and signaling contexts (angiogenesis/immune signaling) that accompany migration. Lesser terms (apoptosis, sodium transport, NK T differentiation) are less defining. Thus, the cluster appears to represent ECM remodeling linked to fibroblast migration.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010763","count":5},{"id":"GO:0030212","count":5},{"id":"GO:0016477","count":4},{"id":"GO:0060709","count":4},{"id":"GO:2001275","count":4}]},{"hash":"412830959112149946","title":"Unknown","description":"The GO terms span muscle development, lipid signaling, metabolism, protein modification, dsRNA response, and cell cycle, with no single coherent shared function. Therefore the cluster cannot be confidently labeled.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":2},{"id":"GO:0046856","count":2},{"id":"GO:0005977","count":1},{"id":"GO:0000272","count":1},{"id":"GO:0006478","count":1}]},{"hash":"1715965253747440829","title":"Developmental and Stress-Response Genes","description":"This set is dominated by embryonic/organogenesis terms such as neural tube closure, forebrain and skeletal system development, and multicellular organism development, suggesting a core developmental program. The presence of terms about cellular responses to cadmium, ER stress\u2013induced apoptotic signaling, and defense responses indicates concurrent stress signaling and apoptosis pathways. Overall, the cluster seems to group genes involved in development with associated cellular stress responses, hence Developmental and Stress-Response Genes as a concise label.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0071276","count":4}]},{"hash":"1561952623016179240","title":"Neural development and apoptosis signaling","description":"The top GO terms center on apoptotic processes, especially neuron-specific apoptosis, and on regulation of signaling pathways such as JNK cascade and canonical Wnt signaling, with involvement of small GTPases. These relate to neural development, cell migration, and peripheral nervous system myelin maintenance, suggesting a neural-survival and development-oriented module. Terms like heart development and insulin signaling appear less central to the cluster\u2019s core theme, but reflect broader developmental signaling contexts. Overall, the cluster appears to represent neural development and apoptotic signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0043525","count":5}]},{"hash":"808015462565763849","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016260","count":3},{"id":"GO:0006541","count":3},{"id":"GO:0009228","count":3},{"id":"GO:0006189","count":3},{"id":"GO:0046892","count":3}]},{"hash":"1420423988734204897","title":"Mitosis and chromatin remodeling","description":"Based on the top GO terms, the cluster is mainly associated with mitotic cell cycle processes, spindle assembly, and chromatin organization, suggesting a core function in cell division and genome regulation. Other terms point to supporting roles in RNA methylation and actin cytoskeleton dynamics, which can be involved in mitotic processes. A distant taste perception term appears to be noise. Overall, the cluster likely represents proteins involved in cell-cycle progression and chromatin organization.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0030042","count":2}]},{"hash":"176018191491049145","title":"Neural development and migration","description":"Based on the presence of brain-development terms (thalamus and striatum development) and a migration term (tangential migration from the subventricular zone to the olfactory bulb), the cluster appears to be centered on neural development and neuronal movement. Other terms (metabolic and stress-response) are present but less cohesive, suggesting noise rather than a unifying metabolic theme.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0021794","count":3},{"id":"GO:0022028","count":2},{"id":"GO:0016114","count":2},{"id":"GO:0072756","count":2}]},{"hash":"53453649951773720","title":"Vacuolar ion transport and acidification","description":"These terms cluster around vacuole biology: acidification, organization, protein trafficking to the vacuole, and membrane transport of Na+ and H+ with copper homeostasis; together suggesting a role in vacuolar ion homeostasis and pH regulation. The energy-related terms hint at coupling of transport to proton motive force, reinforcing this theme.","confidence":"High","size":7,"edges":12,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":3},{"id":"GO:0006814","count":3},{"id":"GO:0015991","count":3},{"id":"GO:0006623","count":3},{"id":"GO:0042777","count":3}]},{"hash":"347945046327276293","title":"Post-transcriptional RNA processing and silencing","description":"The cluster centers on post-transcriptional control: splicing (spliceosome, splice-site recognition, processome assembly), RNA export and stabilization, poly(A) tail regulation, and ncRNA/miRNA-mediated silencing, plus translation initiation components. This suggests a cohesive group of proteins involved in RNA maturation and regulation of gene expression after transcription.","confidence":"High","size":7,"edges":19,"triangles":26,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:1901407","count":5},{"id":"GO:0006376","count":4},{"id":"GO:0006406","count":4}]},{"hash":"1889998046824620177","title":"Neural development and ECM remodeling","description":"This cluster centers on neural development (dendritic spine morphogenesis, synapse organization) and extracellular matrix interactions (collagen fibril organization, slit diaphragm assembly), with broader developmental roles including angiogenesis and vestibular receptor morphogenesis. The shared theme points to ECM-guided tissue development and neural connectivity.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":6},{"id":"GO:0030199","count":5},{"id":"GO:0060116","count":5},{"id":"GO:1904237","count":5},{"id":"GO:0055072","count":5}]},{"hash":"611131626415074362","title":"Morphogenesis and Intracellular Transport","description":"The cluster combines developmental morphogenesis terms (spermatogenesis, spermatid elongation, wing morphogenesis, chaeta morphogenesis) with intracellular transport and cytoskeletal organization (ER-to-Golgi transport, centrosome microtubule anchoring, intraflagellar retrograde transport), suggesting a theme of development shaped by trafficking and cytoskeletal dynamics. An outlier immune-related term exists but does not dominate the signal.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"autophagy","top_go_terms":[{"id":"GO:0006888","count":4},{"id":"GO:0006915","count":3},{"id":"GO:0007290","count":3},{"id":"GO:0034454","count":3},{"id":"GO:0019886","count":3}]},{"hash":"817902972271216419","title":"Membrane Transport and Signaling Regulation","description":"The terms cluster around regulatory controls of membrane-associated processes, including negative regulation of sodium transport across the plasma membrane, plasma membrane to endosome transport, and protein localization to the cell surface, as well as signaling pathways such as TNF and NF-kappaB and related metabolic processes (iron import, heme catabolism, APP biosynthesis). Although the GO terms are diverse and each appears once, the common thread is modulation of membrane trafficking and signaling rather than a single dedicated pathway, suggesting a regulatory rather than effector role at the cell surface. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902306","count":1},{"id":"GO:0048227","count":1},{"id":"GO:1902072","count":1},{"id":"GO:0033209","count":1},{"id":"GO:2000009","count":1}]},{"hash":"895365270190591823","title":"Ubiquitin-dependent proteolysis and TNF signaling","description":"The GO terms center on ubiquitin-dependent protein catabolic processes and sumoylation, with accompanying TNF-mediated signaling, JNK pathway regulation, and apoptosis, plus regulatory effects on muscle and vascular smooth muscle differentiation. This points to a cohesive theme of ubiquitin/SUMO-mediated protein regulation coordinating stress signaling and developmental processes in muscle/vascular contexts.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:1904753","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0097070","count":4},{"id":"GO:0016925","count":4}]},{"hash":"1821349096749340233","title":"Unknown","description":"The GO terms are heterogeneous, including complement pathway regulation (alternative, classical, lectin), PKC signaling regulation, thyroid hormone generation, integrin activation and cell-matrix adhesion, lipoprotein lipase activity, smooth muscle cell apoptotic regulation, and synapse maturation. This mix lacks a single cohesive function across the cluster, so a precise label is not warranted.","confidence":"","size":7,"edges":8,"triangles":0,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0090036","count":3},{"id":"GO:0045957","count":3},{"id":"GO:0006590","count":3},{"id":"GO:0045959","count":3},{"id":"GO:0033623","count":3}]},{"hash":"1185768424622290339","title":"Developmental Differentiation and Organogenesis","description":"GO terms point to neural and organ development, EMT, and epigenetic regulation of gene expression, suggesting a role in coordinated developmental programs across tissues rather than a single pathway. Immune-related terms appear less central to the core theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0061085","count":6},{"id":"GO:0032703","count":6},{"id":"GO:0042421","count":6},{"id":"GO:0035898","count":6},{"id":"GO:0072107","count":6}]},{"hash":"1335995855185452043","title":"Arp2/3-Driven Actin Dynamics in Immune Cells","description":"The cluster focuses on actin cytoskeleton remodeling, with multiple terms for actin polymerization, nucleation, and Arp2/3-mediated processes, plus regulation of actin-based movement and spine morphogenesis. Immune-related GO terms (regulation of T cell antigen processing/presentation and negative regulation of lymphocyte migration) suggest these actin dynamics are tied to immune cell signaling and trafficking, justifying a combined actin remodeling/immune context label.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":3},{"id":"GO:0002625","count":3},{"id":"GO:2000402","count":3},{"id":"GO:0030048","count":3},{"id":"GO:0044397","count":3}]},{"hash":"1332861678932656564","title":"Developmental signaling and vesicle trafficking","description":"The top GO terms cluster around calcium-dependent exocytosis and vesicle fusion, with Rho signaling linking to cytoskeletal dynamics, supporting morphogenesis; plus development-related terms (nervous system, heart, skeletal system) indicating a developmental signaling role. Some terms reflect stress responses that are less central to the core function, but the vesicle trafficking and signaling pattern is evident.","confidence":"Medium","size":7,"edges":17,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":5},{"id":"GO:0001501","count":5},{"id":"GO:0045956","count":5},{"id":"GO:0007266","count":5},{"id":"GO:0007399","count":5}]},{"hash":"132804801785757430","title":"Nuclear receptor signaling and transcription in development","description":"The cluster shows strong representation of DNA-templated transcription and nuclear receptor-mediated signaling (e.g., bile acid signaling) along with transcriptional regulation from RNA polymerase II. The presence of estrogen response and development-related morphogenesis terms (chondroblast differentiation, anterior commissure morphogenesis, spermathecum morphogenesis) suggests a theme of hormone-driven transcriptional control guiding development. Some outliers (like pancreatic juice secretion) exist, but the dominant pattern points to nuclear receptor\u2013dependent transcription in developmental contexts.","confidence":"Medium","size":7,"edges":11,"triangles":3,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0038185","count":3},{"id":"GO:0060591","count":3},{"id":"GO:0045872","count":3},{"id":"GO:0060336","count":3}]},{"hash":"718758310101690687","title":"Male gonad development and miRNA regulation","description":"The top GO terms point to male reproductive development (gonad and seminiferous tubule development) and strong miRNA-mediated post-transcriptional gene silencing signals, with a note of actin filament depolymerization suggesting morphogenesis-related cytoskeleton remodeling. Together, these indicate a cluster of proteins involved in male gonad development with coordinated regulation by miRNA pathways.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0030579","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0035195","count":3}]},{"hash":"1949014860855353350","title":"JNK-Driven Immune Signaling and Oxidative Stress","description":"The top GO terms point to both innate and adaptive immune responses, regulation of the JNK signaling cascade, and cellular responses to hydrogen peroxide, suggesting a cohesive module where stress-activated signaling intersects with immune signaling. Some transcriptional regulation terms are present, but the central theme appears to be JNK-mediated immune/stress responses.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0035186","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0046328","count":3},{"id":"GO:0030890","count":3}]},{"hash":"1195842525701308485","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071033","count":1},{"id":"GO:0034476","count":1},{"id":"GO:0000973","count":1},{"id":"GO:0071039","count":1},{"id":"GO:0071035","count":1}]},{"hash":"484509856027343633","title":"Embryonic organ morphogenesis and immune signaling","description":"The top GO terms point to tissue and organ development processes (mesonephric duct and distal tubule morphogenesis, cartilage condensation, lymph vessel morphogenesis, cell budding) with additional immune-related pathways (complement activation lectin pathway, Fc-gamma receptor signaling, response to fungal origin). This suggests a broad theme of developmental morphogenesis with some immune signaling interplay, hence the chosen label. ","confidence":"Medium","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":3},{"id":"GO:0034394","count":2},{"id":"GO:0007114","count":2},{"id":"GO:0072177","count":2},{"id":"GO:0038094","count":2}]},{"hash":"1225104911419249100","title":"Angiogenic ERK/PI3K signaling","description":"The cluster shows enrichment for angiogenesis and its positive regulation, the ERK1/ERK2 cascade, and PI3K signaling, plus related processes like cell differentiation and protein turnover. This suggests a common theme of growth-factor\u2013driven signaling driving angiogenesis and tissue remodeling, with ERK/PI3K pathways as central hubs. Some terms (e.g., fungal response, LTP) are more divergent, but the dominant theme points to signaling pathways coordinating angiogenesis and differentiation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0032436","count":4},{"id":"GO:0071226","count":4},{"id":"GO:0070371","count":3}]},{"hash":"97367306461845993","title":"Innate immune defense and antimicrobial response","description":"Most of the top GO terms cluster around innate immunity and antimicrobial defense, including macrophage activation, defense response to Gram-positive bacteria, antibacterial peptide biosynthetic process, TLR signaling, and response to dsRNA. While a few terms reference ECM remodeling or plant-specific processes, the immune-related terms dominate, supporting a coherent theme of immune sensing and antimicrobial defense. Therefore, the cluster is best described as an innate immune/antimicrobial response group. ","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0009934","count":4},{"id":"GO:0090141","count":4},{"id":"GO:0034166","count":4}]},{"hash":"542436580068187981","title":"Dendritic Cell Activation and Interferon Signaling","description":"The top terms include plasmacytoid dendritic cell activation and positive regulation of interferon-alpha production, pointing to an immune/innate signaling theme. Although other terms touch on development and signaling pathways, the immune-related terms best represent the cluster's core function. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000761","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0033234","count":2},{"id":"GO:0003308","count":2},{"id":"GO:0071560","count":2}]},{"hash":"137393743654601269","title":"Ubiquitin-Proteasome System and NF-\u03baB Signaling","description":"The proteins are enriched for proteasome-related processes (core assembly, ubiquitin-independent proteolysis, deubiquitination) and immune signaling pathways (non-canonical NF-\u03baB, TNF signaling, antigen presentation via MHC I), indicating a coordinated role in protein turnover linked to immune activation.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010950","count":5},{"id":"GO:0016579","count":4},{"id":"GO:0046686","count":4},{"id":"GO:0033209","count":4},{"id":"GO:0010499","count":4}]},{"hash":"1272010488617083528","title":"Immune Activation and Cytokine Signaling","description":"The cluster\u2019s top GO terms concentrate on innate and adaptive immune responses and cytokine signaling, including IL-2 production regulation, innate immune response, B cell activation, and cytokine production in the immune response. A few terms reference neuronal axon guidance and cardiac depolarization, but the predominant signal is immune-related, indicating proteins that participate in immune activation and cytokine-mediated communication.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900042","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0031532","count":2},{"id":"GO:0002859","count":1}]},{"hash":"1438314359422056757","title":"Translational Machinery and Regulation","description":"The dominant GO terms revolve around translation at multiple stages (initiation, elongation, termination, cytoplasmic translation) and its positive regulation, indicating a cluster centered on protein synthesis and its control. A few outliers involving RNA silencing\u2013related chromatin regulation, antibiotic response, and glial proliferation are present but less representative of the core function.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006415","count":3},{"id":"GO:0045901","count":2},{"id":"GO:0045903","count":2},{"id":"GO:1902802","count":2}]},{"hash":"1175585491788962230","title":"Cell cycle regulation and transcription control","description":"This cluster centers on cell cycle progression (cell cycle, mitotic phase transitions, meiosis I, cell proliferation) and transcriptional control (regulation of transcription by RNA Pol II, activation/positive regulation of transcription and kinase activity including CDKs), suggesting proteins that coordinate division with gene expression. The histoblast morphogenesis term hints development-related context but the dominant signal is cell cycle and transcription regulation.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0007127","count":2},{"id":"GO:0060303","count":2},{"id":"GO:0006357","count":2},{"id":"GO:0044772","count":2}]},{"hash":"2280537062121945951","title":"mRNA processing and post-transcriptional regulation","description":"The cluster includes terms tied to mRNA export, splicing regulation, splice site recognition, mRNA stabilization, poly(A) tail regulation, and ncRNA/miRNA-mediated silencing that affects translation, plus translation preinitiation complex formation. Collectively, these reflect coordinated post-transcriptional control of gene expression at the level of RNA processing and translation initiation, rather than transcriptional regulation or protein degradation.","confidence":"High","size":7,"edges":18,"triangles":20,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":6},{"id":"GO:0000381","count":6},{"id":"GO:0006376","count":5},{"id":"GO:0048255","count":5},{"id":"GO:0035278","count":5}]},{"hash":"1480003122947535869","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030388","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0006094","count":2},{"id":"GO:0061621","count":2},{"id":"GO:0051289","count":2}]},{"hash":"1630802612254733758","title":"Post-transcriptional mRNA regulation","description":"These terms collectively define post-transcriptional control of mRNA\u2014splicing and spliceosome activity, nuclear export, polyadenylation regulation, mRNA stability, and initiation/translation control, including miRNA-mediated silencing. The cluster appears to group proteins involved in shaping mRNA fate after transcription.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006406","count":7},{"id":"GO:0031047","count":7},{"id":"GO:0048026","count":7},{"id":"GO:1900363","count":7},{"id":"GO:0006446","count":7}]},{"hash":"696374695237718871","title":"Unknown","description":"The GO terms are diverse and largely unrelated (ubiquitin-dependent ERAD, cell cycle regulation, TGF-beta response, chromatin organization, histone acetylation, osteoblast differentiation, immune defense), with no single enriched function connecting most proteins, and no edges to indicate a coherent module.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0031497","count":1}]},{"hash":"125291615837911208","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms cluster around ubiquitination and proteolysis, including ubiquitin-dependent protein catabolic process, ubiquitination (K6-linked), and protein autoubiquitination, plus histone catabolic process. Some immune signaling terms (TNF signaling, JNK regulation) are frequently controlled by ubiquitin chains, reinforcing a unifying theme of protein turnover and regulation via ubiquitination.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0085020","count":6},{"id":"GO:0051865","count":6},{"id":"GO:0036205","count":6},{"id":"GO:1901253","count":6}]},{"hash":"1052214312836731005","title":"T cell apoptosis and adhesion signaling","description":"The top GO terms center on activation-induced T cell death and regulation of extrinsic apoptotic signaling, with additional signals for cell-matrix adhesion and integrin activation, suggesting a cluster of proteins that couple immune cell apoptosis with cell-ECM adhesion/modulation. Other terms like negative regulation of complement activation and thyroid hormone generation are present but less central, so the main theme appears to be apoptotic/immune regulation linked to adhesion signaling.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0006924","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0090036","count":1},{"id":"GO:0045957","count":1}]},{"hash":"976433852842696769","title":"Amino acid and energy metabolism","description":"Based on the GO terms, the cluster is enriched for amino acid metabolism (leucine catabolic process, arginine biosynthesis, glutamine metabolism) and core energy pathways (glycolysis, regulation of fatty acid beta-oxidation), with additional signals of general metabolic/ stress responses (response to dexamethasone, response to amine). Although a couple of terms (DNA replication, viral RNA genome packaging) are unrelated noise, the dominant theme is metabolic processes centered on amino acid turnover and energy production, so the label reflects the shared function reasonably well.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0043200","count":1},{"id":"GO:0006552","count":1},{"id":"GO:0071548","count":1},{"id":"GO:0019074","count":1}]},{"hash":"1032519392097792628","title":"Regulated Translation Machinery","description":"Most top GO terms point to various aspects of protein synthesis and its control\u2014translation in general, initiation, elongation, fidelity, cytoplasmic translation, and selenocysteine incorporation\u2014indicating a core function in regulating translation. A few terms (antibiotic response, glial proliferation, and RNAi-related chromatin regulation) appear incidental to the main theme. Therefore, the cluster is best described as proteins involved in regulated translation.","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":4},{"id":"GO:0045901","count":3},{"id":"GO:0045903","count":3},{"id":"GO:1902802","count":3}]},{"hash":"496272228924264607","title":"Ubiquitination and proteostasis regulation","description":"The top terms cluster around protein ubiquitination (ubiquitin-dependent ERAD, autoubiquitination, K63-linked ubiquitination) and related protein quality control processes, with supporting hints from phosphorylation and chaperone complex assembly. Although a few terms touch on DNA replication termination or photomorphogenesis, the strongest theme is ubiquitin signaling governing protein degradation and quality control.","confidence":"Medium","size":7,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0051865","count":1},{"id":"GO:0071171","count":1},{"id":"GO:0090035","count":1}]},{"hash":"1871413553092454534","title":"Neural Lipid Biosynthesis and Myelination","description":"The cluster includes GO terms for brain development, neuronal signal transduction, and CNS myelin maintenance, alongside lipid metabolism processes such as unsaturated fatty acid biosynthesis, ether lipid metabolism, and sterol/ergosterol-related biosynthesis. This points to a cohesive theme where lipid production supports neural development and myelin integrity, with other terms (mitochondrion inheritance, B cell chemotaxis) likely representing peripheral or noisy associations. ","confidence":"Medium","size":7,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0023041","count":2},{"id":"GO:0032286","count":1},{"id":"GO:0000001","count":1},{"id":"GO:0006636","count":1}]},{"hash":"442926156675734430","title":"Renin\u2013angiotensin signaling and kidney development","description":"The cluster's top terms center on hormone-mediated signaling, renin-angiotensin regulation of aldosterone production, and angiotensin maturation, along with mesonephros development, which together suggest a renal endocrine theme. While other terms such as digestion and antigen processing appear, they are less aligned with the dominant renal/hormonal pattern.","confidence":"Medium","size":7,"edges":10,"triangles":4,"max_degree":5,"top_function":"autophagy","top_go_terms":[{"id":"GO:0007586","count":3},{"id":"GO:0009755","count":3},{"id":"GO:0035902","count":3},{"id":"GO:0002018","count":3},{"id":"GO:0001823","count":3}]},{"hash":"81264949071817056","title":"Regulatory Signaling in Growth and Neural Development","description":"This cluster's top GO terms center on regulation and signaling affecting growth (insulin receptor signaling, T cell receptor signaling, CDK activity, proliferation) as well as neural development (cerebellar cortex formation, Bergmann glial differentiation). The presence of kinetochore localization also ties to cell division control, suggesting a broad theme of signaling pathways that govern growth and development across tissues. Therefore, this label captures the overarching regulatory signaling theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0050852","count":6},{"id":"GO:2001275","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0045736","count":6}]},{"hash":"320422713083814838","title":"Transmembrane transporters","description":"The GO terms are dominated by transmembrane transport activities across diverse substrates, including neurotransmitter loading into vesicles, sugars (arabinose, galactose), ions (potassium, phosphate), and various small molecules (nitrate, nitrite, sialic acid, xenobiotics). This pattern points to a cluster of membrane transporter proteins with broad substrate specificity, rather than a single enzyme or non-transport function. The neuron-specific term coexists with general transporter terms, but the unifying theme remains transport across membranes.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":2},{"id":"GO:0015751","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0015706","count":2}]},{"hash":"308743614333566940","title":"TGF-beta/BMP Signaling Regulation","description":"Most terms point to regulation and response of TGF-beta/BMP signaling and SMAD complex activity (negative regulation of BMP signaling, cellular response to TGF-beta stimulus, and SMAD-related assembly/dephosphorylation), suggesting a cohesive theme of signaling modulation. A couple of terms (meristem maintenance, photosystem stoichiometry adjustment) seem less connected, likely noise or broad annotations, but the core cluster appears centered on TGF-beta/BMP pathway regulation.","confidence":"Medium","size":7,"edges":10,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042006","count":2},{"id":"GO:0030512","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0080005","count":2},{"id":"GO:0010991","count":2}]},{"hash":"1481232148831928942","title":"Unknown","description":"The top GO terms are a mix of inflammatory responses, mechanical stimulus response, tissue remodeling (collagen fibril organization, hair follicle development), and assorted unrelated processes (response to metals, intestinal glucose absorption, plant meristem organization). There\u2019s no clear, cohesive theme or shared function linking these proteins, and there are no edges among them, so a specific, representative label isn\u2019t supported.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:0006954","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0071285","count":2}]},{"hash":"542401143117904108","title":"Unknown","description":"The top terms show a mix of immune defense (defense against Gram-positive bacteria; antibacterial humoral response) and neural/transport roles (dopaminergic synaptic transmission; neurotransmitter loading into vesicles; various metabolite/ion transports) with no clear, single cohesive function. Because there isn\u2019t a unifying theme, a specific label isn\u2019t justifiable.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0001963","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0019731","count":2},{"id":"GO:0098700","count":1}]},{"hash":"443290138678246289","title":"Chromatin-Driven Transcription Regulation","description":"The cluster's frequent GO terms center on transcriptional control and chromatin processes (DNA-templated transcription, its positive regulation, and histone-related activity such as RITS complex assembly and histone deubiquitination). Neuronal development terms appear but are compatible with transcriptional regulation guiding neural differentiation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904802","count":2},{"id":"GO:0016578","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045893","count":2},{"id":"GO:0043569","count":2}]},{"hash":"111997353336111798","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000480","count":1},{"id":"GO:0000447","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0070236","count":1},{"id":"GO:0048642","count":1}]},{"hash":"2236646477659124429","title":"Secretory vesicle trafficking and exocytosis","description":"The cluster is characterized by GO terms tied to vesicle trafficking and secretion, including intra-Golgi and Golgi-to-plasma membrane transport, exocytosis, SNARE complex assembly, exocyst localization, and mucus secretion, indicating a shared role in secretory pathway machinery and regulated vesicle fusion.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090190","count":2},{"id":"GO:0070254","count":1},{"id":"GO:0006891","count":1},{"id":"GO:0043312","count":1},{"id":"GO:0006887","count":1}]},{"hash":"2001443702883227833","title":"Developmental cell migration and cytoskeleton remodeling","description":"The top GO terms cluster around cell movement and cytoskeletal dynamics (dendritic cell migration, radial glia-guided migration of Purkinje cells), Rac-mediated signaling, and actin remodeling, with supporting roles from adherens junction organization and vesicle trafficking. The inclusion of cell cycle exit and growth terms suggests coordination of proliferation and developmental timing with migration; overall, the cluster points to proteins involved in developmental cell migration and structural remodeling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0036336","count":2},{"id":"GO:0016601","count":2},{"id":"GO:0021942","count":2},{"id":"GO:0010458","count":2}]},{"hash":"1468405244243267637","title":"Unknown","description":"The GO terms are highly diverse, spanning muscle development and sarcomere organization, cell division (mitotic spindle assembly, chromosome passenger complex localization to spindle midzone), immune signaling, circadian rhythm regulation, and even plant metabolism, with no single coherent function linking them all. This lack of a unifying theme suggests no reliable, representative label for the cluster. ","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":4},{"id":"GO:0045214","count":3},{"id":"GO:0006919","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0019762","count":2}]},{"hash":"1308781195161026194","title":"Chromatin regulation and transcription control","description":"The top GO terms emphasize chromatin state regulation (DNA methylation\u2013dependent heterochromatin formation, nucleosome density, histone modifications) and transcriptional control, suggesting a cohesive theme around how chromatin structure governs gene expression, with some additional, less central terms related to development and stress responses.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000083","count":6},{"id":"GO:0006346","count":6},{"id":"GO:0070845","count":6},{"id":"GO:1901300","count":6},{"id":"GO:0048742","count":6}]},{"hash":"1164553586328249784","title":"Mitotic spindle assembly and microtubule dynamics","description":"This cluster is dominated by GO terms for plus/minus end microtubule movement, spindle assembly, centrosome separation, and kinetochore attachment, indicating proteins that organize and regulate the mitotic spindle and microtubule polarity during cell division. Tissue-context terms hint broader roles but do not override the central mitotic motif.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0070462","count":6},{"id":"GO:0021685","count":6},{"id":"GO:0031535","count":6},{"id":"GO:0099607","count":6},{"id":"GO:0000022","count":6}]},{"hash":"689477011957563261","title":"ER Stress and Innate Immune Signaling","description":"This cluster centers on ER-associated stress responses (unfolded protein response and protein folding) coupled with innate immune signaling (non-canonical NF-\u03baB pathway, innate immune activation) and regulation of phagocytosis, suggesting a coordinated stress-immune function. Some terms like development and senescence may reflect secondary responses to cellular stress. Overall, it represents stress-related immune and phagocytic activity.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"protein folding","top_go_terms":[{"id":"GO:0048488","count":3},{"id":"GO:0006457","count":3},{"id":"GO:1901224","count":3},{"id":"GO:0010204","count":3},{"id":"GO:0033144","count":3}]},{"hash":"38186722384880887","title":"Mitotic spindle assembly and microtubule dynamics","description":"This cluster centers on microtubule-based spindle formation and dynamics, given GO terms for plus/minus-end microtubule sliding, end depolymerization, spindle assembly/elongation, centrosome separation, kinetochore attachment, and maintenance of microtubule polarity. A few terms touch on tissue-specific structures, but the dominant theme is mitotic spindle organization and cytoskeletal dynamics.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070462","count":2},{"id":"GO:0021685","count":2},{"id":"GO:0031535","count":2},{"id":"GO:0099607","count":2},{"id":"GO:0000022","count":2}]},{"hash":"1507058171764244947","title":"DNA replication and proteostasis","description":"Based on the top GO terms, this cluster is centered on core DNA replication activities (leading strand elongation, replication processes, and checkpoint signaling) suggesting involvement in S-phase/cell cycle progression. It also shows protein quality control themes (response to misfolded proteins, ERAD, and chaperone-related refolding), implying co-regulation of replication with proteostasis. A vesicle transport term is present but appears secondary to these core functions.","confidence":"Medium","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0048219","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0016485","count":4},{"id":"GO:0006272","count":4}]},{"hash":"1131576637468324077","title":"Transmembrane transport and metabolism","description":"This cluster centers on membrane transport of small molecules (xenobiotics, pantothenate, thyroid hormone) and a set of metabolic processes (retinol, purine, allantoin, urate), with additional peripheral signals related to extracellular matrix and immune activity. The shared theme appears to be transporter-associated metabolism rather than a single pathway, giving a coherent but somewhat broad label.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0030198","count":1},{"id":"GO:0019428","count":1},{"id":"GO:0006144","count":1},{"id":"GO:0001560","count":1}]},{"hash":"1053547090478042917","title":"Ubiquitin-Dependent Protein Degradation and ERAD","description":"Top GO terms indicate a strong focus on ubiquitin-mediated proteolysis, including ubiquitin-dependent protein catabolic processes, ERAD, and K48-linked ubiquitination, with autoubiquitination also represented. While some terms touch on circadian regulation, Wnt receptor turnover, and X chromosome dosage effects, the dominant pattern ties to ubiquitin-driven protein degradation and turnover. This cluster most likely reflects components of the ubiquitin-proteasome/ERAD proteolysis axis.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0030433","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0042752","count":2},{"id":"GO:0038018","count":2}]},{"hash":"1494133766203386480","title":"Mitochondrial apoptosis","description":"The two top GO terms are apoptotic process and mitochondrial translation, pointing to mitochondria as a central context. This suggests the proteins may function in mitochondrial protein synthesis and/or regulation of apoptosis, consistent with a mitochondria-associated apoptotic pathway. Therefore, labeling the cluster as mitochondrial apoptosis is a concise, representative summary.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":6},{"id":"GO:0032543","count":6}]},{"hash":"432735538629220416","title":"Metal-responsive neuronal ubiquitin-proteasome regulation","description":"This cluster centers on ubiquitin-mediated protein turnover (polyubiquitination and SCF-dependent proteasomal degradation) and its regulation, with additional signals of neuronal context (synapse assembly, neural tube closure initiation) and metal-stress responses (cadmium and methylmercury). Together, they suggest proteins involved in ubiquitin-dependent proteostasis in neurons under metal-induced stress, potentially impacting neural development or synaptic maturation in such conditions.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0071276","count":5},{"id":"GO:1903378","count":4},{"id":"GO:0071406","count":4}]},{"hash":"280615765759207441","title":"Ubiquitin-Regulated Mitosis and Antiviral Defense","description":"This cluster highlights ubiquitin-mediated regulation of mitosis (APC-dependent processes, K11-linked ubiquitination) alongside innate immune and antiviral responses, suggesting a set of proteins coordinating cell cycle control with defense signaling.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0045842","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0070979","count":3}]},{"hash":"1935649891769162830","title":"LPS and O-antigen Biosynthesis with Sugar Metabolism","description":"The strongest signals are lipopolysaccharide biosynthesis and O-antigen biosynthesis, along with GDP-mannose and UDP-N-acetylglucosamine biosynthesis, plus glucose-1-phosphate metabolism. Together these point to a cluster focused on building the bacterial cell envelope and related sugar building blocks. Some terms (gravity detection, nucleoside catabolism) are peripheral outliers, but do not negate the central theme.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":3},{"id":"GO:0006564","count":3},{"id":"GO:0019388","count":2},{"id":"GO:0009590","count":2},{"id":"GO:0019255","count":2}]},{"hash":"1178101759621041678","title":"Mitotic cell cycle and transcription regulation","description":"The top GO terms are dominated by mitosis-related processes (mitotic cell cycle, cell division, regulation of cell cycle checkpoint) and transcription (DNA-templated transcription), with supporting signals for GTPase activity regulation and ER-Golgi transport, pointing to a cluster of proteins involved in cell-cycle control and coordination of gene expression. Some chromatin modification terms appear as obsolete entries, and a brain development term appears infrequently, suggesting broader regulatory roles rather than a single specialized pathway. Overall, the cluster centers on mitotic regulation with linked transcriptional and trafficking activities.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0051568","count":3}]},{"hash":"1856191203613102272","title":"Integrin signaling and ECM-mediated cell adhesion","description":"The cluster is dominated by GO terms related to integrin signaling, cell-matrix adhesion, substrate-dependent migration, and cell-cell adhesion, pointing to a coherent theme of extracellular matrix interactions guiding cell adhesion and movement. A few terms reference developmental processes or plant-specific pathways, which may reflect cross-species annotations or broader functional annotations in the set, but the strongest signal centers on adhesion and ECM signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0015995","count":3},{"id":"GO:0003429","count":3},{"id":"GO:0070208","count":3}]},{"hash":"2076758346522360484","title":"Ubiquitin-Dependent Proteostasis and Stress Signaling","description":"These proteins cluster around ubiquitin-mediated quality control (ubiquitin-dependent ERAD, protein autoubiquitination) and degradation/autophagy (mitophagy), with additional involvement in regulating key signaling pathways (TNF and Toll-like receptor signaling) and gene expression processes (RNA Pol II transcription, ribosomal assembly). The common theme is proteostasis and stress response regulation via ubiquitin tagging and turnover, coupled to broader control of signaling and transcription. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:1903265","count":4},{"id":"GO:0051865","count":4},{"id":"GO:1901340","count":4},{"id":"GO:1904049","count":4}]},{"hash":"1143878707723139746","title":"Unknown","description":"The terms cover a broad mix of stress responses, metabolism, signaling, and development with no single dominant function linking them, and there are no connecting edges among the proteins. This makes it hard to assign a concise, cohesive label, so Unknown with no confidence is appropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0071375","count":2},{"id":"GO:0070266","count":2},{"id":"GO:0030980","count":2},{"id":"GO:0005980","count":2}]},{"hash":"980340438074481928","title":"Lipid Transport and Metabolism","description":"The cluster\u2019s terms center on lipid handling (very long-chain fatty acid catabolism, ceramide translocation, fenofibrate response) and membrane-associated transport across organelles (cytosol-to-ER transport, xenobiotic transmembrane transport, cobalt ion transport, membrane hyperpolarization). While some terms relate to mitochondrial/ER processes and transport rather than a single enzyme activity, the overarching theme is intracellular lipid trafficking and lipid-mediated transport/metabolism. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042760","count":6},{"id":"GO:0090374","count":6},{"id":"GO:0099040","count":6},{"id":"GO:0006824","count":6},{"id":"GO:0017004","count":6}]},{"hash":"587929733195076602","title":"Polysaccharide and LPS Biosynthesis","description":"The top GO terms cluster around biosynthesis of polysaccharides and related surface components, including lipopolysaccharide, colanic acid, extracellular polysaccharide, and sugar precursors like UDP-L-arabinose and galacturonate, pointing to a shared role in constructing cell envelope polysaccharides and exopolysaccharides.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":3},{"id":"GO:0009244","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0009242","count":2},{"id":"GO:0045226","count":2}]},{"hash":"1615003288508889078","title":"Gonadal and skeletal development","description":"Reasoning: The top GO terms are dominated by developmental processes, notably spermatid development, male gonad development, and osteoblast differentiation, with a general signal for multicellular organism growth. This points to a cohesive theme around gonadal and bone development and tissue differentiation. A few terms (plasminogen activation, non-stop decay, histone methylation regulation, defense response) are more divergent and may reflect broader regulatory roles or annotation overlap, but the central theme remains developmental differentiation in reproductive and skeletal tissues.","confidence":"Medium","size":6,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":5},{"id":"GO:0007286","count":5},{"id":"GO:0051572","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0001649","count":5}]},{"hash":"2011622983989918726","title":"DNA replication and transcription/splicing regulation in development","description":"The cluster is dominated by nuclear processes: DNA replication, DNA-templated transcription, cell cycle, and RNA processing/splicing, with peptidyl-tyrosine phosphorylation hinting at signaling regulation. The embryonic cranial skeleton morphogenesis term suggests a developmental context, tying these gene expression and genome-maintenance activities to development. A few terms (obsolete or peripheral) likely reflect annotation noise or broader regulatory themes.","confidence":"High","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0018108","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0018144","count":2}]},{"hash":"300368187914681070","title":"Developmental Signaling and Adhesion","description":"The top GO terms cluster around receptor trafficking and signaling (receptor internalization; cellular response to TGF-beta), cell\u2013cell/matrix interactions (regulation of integrin activation; paranodal junction assembly), and developmental patterning (somite axis specification; imaginal disc growth) suggesting a theme of signaling and adhesion processes driving development. Some terms (oxidation-reduction; intestinal glucose absorption) appear peripheral and may reflect noise. Overall, the cluster seems to represent developmental signaling and adhesion.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":2},{"id":"GO:0008285","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0001951","count":1}]},{"hash":"1740375677678300830","title":"Ubiquitination and SUMOylation in Proteostasis","description":"The cluster revolves around post-translational modification and protein quality control, with GO terms for ubiquitination, deubiquitination, sumoylation, and proteasome regulation (and ERAD involvement), indicating a proteostasis-focused module, though ribosome assembly is a weaker linking feature.","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0016579","count":4},{"id":"GO:0000028","count":4},{"id":"GO:1901799","count":4}]},{"hash":"1399986728114080662","title":"Muscle calcium handling and fiber-type transition","description":"The top GO terms cluster around calcium transport, calcium import into the sarcoplasmic reticulum, and T-tubule organization, all central to muscle excitation-contraction coupling. The inclusion of a fast/slow fiber transition term reinforces a muscle-focused theme. A few terms (mammary gland involution, methylmercury/glycoside responses) appear unrelated noise, but do not override the dominant muscle calcium signaling signal.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070588","count":3},{"id":"GO:0014883","count":3},{"id":"GO:0060056","count":2},{"id":"GO:0051597","count":2},{"id":"GO:1903416","count":2}]},{"hash":"415569185464555750","title":"Transmembrane Solute Transport","description":"Dominant GO terms describe transmembrane transport of diverse solutes (fructose, aspartate, bicarbonate, sulfate, oxalate) and regulation of membrane potential, with some membrane-related processes (gastric acid secretion, sperm capacitation, sporulation). Overall, the cohesive theme is solute transport across membranes, implying the cluster consists mainly of transporters or regulators of transport. The absence of interactions (Edges 0) limits deeper functional linking.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0015755","count":4},{"id":"GO:0042391","count":4},{"id":"GO:0030435","count":4},{"id":"GO:0089712","count":4},{"id":"GO:0048240","count":4}]},{"hash":"2209307230760338561","title":"Unknown","description":"The top GO terms are broad and span development, apoptosis, stress responses, sensory perception, and general cellular processes with no clear, single theme tying all six proteins together, so a specific label cannot be supported.","confidence":"","size":6,"edges":8,"triangles":1,"max_degree":4,"top_function":"wound healing","top_go_terms":[{"id":"GO:0016485","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0016241","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0046677","count":3}]},{"hash":"1180131239505441382","title":"DNA damage response and RNA processing","description":"The cluster features clear signals of genome maintenance (DNA damage checkpoint signaling, cellular response to ionizing radiation, meiotic recombination checkpoint signaling) alongside RNA processing and regulation activities (mRNA splicing, nuclear export, stabilization, and miRNA-mediated silencing). The shared theme centers on nucleic acid metabolism coupled with genome integrity surveillance, though one term (substantia nigra development) is an outlier. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0000077","count":1},{"id":"GO:0071479","count":1},{"id":"GO:0021762","count":1},{"id":"GO:0051598","count":1}]},{"hash":"1004296594303636102","title":"Cell Cycle and Vesicle Trafficking","description":"The cluster is dominated by the cell cycle term (GO:0007049) and includes several vesicle trafficking processes (Golgi to plasma membrane, and plasma membrane to endosome, plus vacuolar membrane localization), along with related signaling (Rap, kinase activity regulation). This suggests a coordinated role in cell division with intracellular transport and signaling, rather than a single, specialized pathway. Some peripheral terms (immune and drug response) appear less central to the core theme. ","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007049","count":6},{"id":"GO:0097327","count":5},{"id":"GO:0048227","count":5},{"id":"GO:1903778","count":5},{"id":"GO:0000001","count":5}]},{"hash":"2091092908764143248","title":"Broad cell signaling and vesicle trafficking","description":"The GO terms here point to diverse signaling pathways (NF-kappaB, phosphatidylinositol signaling, calcium response, VEGF receptor signaling, Fc-epsilon receptor signaling) and vesicle-related processes (neurotransmitter secretion, regulation of synaptic vesicle exocytosis), suggesting a cluster of proteins involved in signal transduction and vesicle dynamics. A couple of mitosis-related terms appear but do not define a single cohesive function; overall the group seems to-center on signaling and vesicle function across contexts.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0038095","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0043065","count":2}]},{"hash":"1404802154870131554","title":"DNA Damage Response and Apoptosis Signaling","description":"This cluster is dominated by GO terms for DNA-templated transcription, DNA damage checkpoint signaling, and apoptosis-related processes (death-inducing signaling complex assembly and execution phase of apoptosis), suggesting a core theme of DNA damage response leading to programmed cell death. Other terms hint at additional stress responses but do not override the central mechanism.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000077","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0071550","count":2},{"id":"GO:0048538","count":2}]},{"hash":"1901875250231592834","title":"TNF/NF-\u03baB immune signaling and ubiquitination","description":"The terms cluster around TNF-mediated signaling and NF-kappaB activation, with multiple mentions of ubiquitination processes (autoubiquitination, polyubiquitination, ERAD). Additional terms point to innate immune response and adaptive immunity aspects (T follicular helper cell differentiation, lymph node development). This suggests a cohesive functional theme of NF-\u03baB\u2013driven immune signaling modulated by ubiquitin pathways across innate and adaptive responses, hence the proposed label.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051092","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0033209","count":5},{"id":"GO:0051865","count":5},{"id":"GO:1903265","count":5}]},{"hash":"1297712040545516126","title":"Skeletal muscle contraction and sarcomere organization","description":"The cluster\u2019s top GO terms are dominated by muscle-related processes such as muscle filament sliding, skeletal muscle contraction, slow-twitch fiber contraction, and sarcomere organization, with both positive and negative regulation of ATP-dependent activity; vascular terms like vasculogenesis and blood pressure regulation may reflect broader muscle physiology, but the dominant signal is skeletal muscle contraction and sarcomere structure.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030049","count":1},{"id":"GO:0001570","count":1},{"id":"GO:0032780","count":1},{"id":"GO:0003009","count":1},{"id":"GO:0045932","count":1}]},{"hash":"175487565426849938","title":"T cell\u2013mediated apoptosis and immune signaling","description":"This cluster centers on apoptotic processes and T cell\u2013related immune functions, with GO terms for extrinsic apoptotic signaling, DNA damage checkpoints, cytotoxic T-cell activity, TNF production, and thymic T cell differentiation, suggesting coordinated regulation of programmed cell death within immune cells. Some terms like spleen development or response to cocaine appear tangential but do not override the core theme.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097049","count":1},{"id":"GO:0001916","count":1},{"id":"GO:0030262","count":1},{"id":"GO:0032760","count":1},{"id":"GO:0000077","count":1}]},{"hash":"1389991482041950882","title":"Unknown","description":"The terms are a mix of diverse/broad processes (sterol and polyamine and antibiotic biosynthesis), RNA modification (guanine-N7 methylation and tRNA wobble), ribosomal export, and various stress/response terms (immobilization, amine, cocaine). There isn\u2019t a single coherent function tying these together, so a specific, intuitive label isn\u2019t supported. ","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0006596","count":2},{"id":"GO:0070476","count":2},{"id":"GO:0035902","count":2}]},{"hash":"1258702720617177351","title":"Antigen processing and immune signaling with proteasome regulation","description":"The terms center on antigen processing and presentation, immune signaling (IL-2 production, TGF-beta response), and proteasome/ proteolysis (regulation of proteasomal protein catabolic process, endopeptidase activity) with lysosomal/vacuolar localization, which together suggest a cluster focused on immune antigen processing and proteostasis. Some other terms (cell cycle, actin branching) seem less directly related and may be incidental. Confidence: Medium","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019884","count":1},{"id":"GO:2000045","count":1},{"id":"GO:0061136","count":1},{"id":"GO:0010950","count":1},{"id":"GO:1903778","count":1}]},{"hash":"988575074307678833","title":"GPCR Signaling in Heart and Nervous System","description":"The cluster is dominated by GO terms related to G protein-coupled receptor signaling, GPCR internalization, and regulation of GTPase activity, plus terms tied to heart development and catecholamine secretion. This points to a coherent theme of GPCR-mediated signaling in cardiac and neural functions, with supplementary terms reflecting broader signal transduction and regulation. Some outlier terms exist, but they don\u2019t override the central GPCR/heart-neural axis.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031914","count":2},{"id":"GO:0003315","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0003108","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1714147297966929687","title":"Unknown","description":"The terms are too diverse to reveal a single functional theme: transcriptional repression, stem cell maintenance, angiogenesis-related apoptosis, vitellogenesis, taste perception, fatty acid oxidation, phosphatidylcholine biosynthesis, insulin signaling, T cell migration regulation, and triglyceride catabolism. With no interactions among proteins, there\u2019s no cohesive pathway tying them together, so there is no reliable label beyond Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0035019","count":2},{"id":"GO:1902262","count":2},{"id":"GO:0007296","count":2},{"id":"GO:0050909","count":1}]},{"hash":"2179337834704268725","title":"RNA splicing and mRNA processing cluster","description":"These terms cluster around mRNA splicing, export, stabilization, and translation initiation, plus regulation of poly(A) tail shortening, pointing to an RNA maturation and post-transcriptional processing module. The miRNA- and regulatory ncRNA-mediated silencing terms indicate additional layers of gene expression control connected to this RNA processing machinery.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0048255","count":2},{"id":"GO:0035278","count":2},{"id":"GO:0031047","count":2}]},{"hash":"452739747023190523","title":"Mitochondrial metabolism and proliferation signals","description":"Dominant terms point to mitochondrial energy production (electron transport; complex II assembly) and proliferation-related processes (G1/S transition; mammary gland and liver regeneration), suggesting a link between mitochondrial function and cell proliferation. Several other terms appear unrelated or noisy (response to vitamin E, early viral transcription, obsolete terms), which lowers the overall confidence. ","confidence":"Medium","size":6,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1},{"id":"GO:0034553","count":1},{"id":"GO:0000082","count":1},{"id":"GO:0033197","count":1},{"id":"GO:0010673","count":1}]},{"hash":"1543171882892373109","title":"Integrin signaling and focal adhesion in osteoblasts","description":"Top GO terms suggest a module of proteins involved in integrin-mediated signaling and regulation of focal adhesions, including cell adhesion via integrins and osteoblast differentiation, with additional connections to TNF/NF-kappaB and ephrin signaling. This pattern points to a signaling/adherence network at focal contacts that also interfaces with inflammatory pathways, potentially linking adhesion dynamics to osteoblast function. Confidence reflects a coherent theme but some immune-related terms introduce broader signaling context. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0007229","count":2},{"id":"GO:0033628","count":2}]},{"hash":"2114593983817450105","title":"JAK-STAT Cytokine Signaling in T Helper Cells","description":"The most frequent terms describe positive regulation of STAT tyrosine phosphorylation and IL-2/IL-27 signaling, together with T helper 2 cytokine production, pointing to JAK-STAT\u2013driven cytokine signaling in T cells. A few non-immune terms exist but are weaker signals.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042523","count":5},{"id":"GO:0035745","count":5},{"id":"GO:0042517","count":5},{"id":"GO:0070106","count":5},{"id":"GO:0038110","count":4}]},{"hash":"1555336677567647724","title":"Glycan processing and protein glycosylation","description":"This cluster is driven by GO terms related to glycan metabolism and protein glycosylation (N-glycan processing, N-linked glycosylation via asparagine, protein sialylation, glycosylceramide and oligosaccharide metabolism), with a few terms touching on olfactory and pollen development likely reflecting glycoprotein roles in development. The strongest shared theme is carbohydrate modification pathways.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006054","count":2},{"id":"GO:0071699","count":2},{"id":"GO:0006491","count":2},{"id":"GO:0021628","count":2},{"id":"GO:1990743","count":2}]},{"hash":"1532561630099425272","title":"Mitochondrial Import and Cell Cycle Regulation","description":"This cluster centers on mitochondrial-related processes (protein import into the mitochondrial matrix and regulation of mitochondrial membrane permeability) alongside various regulators of cell growth and division (regulation of the cell cycle, mitotic transition regulation, and mediator complex assembly). The mix suggests a theme of mitochondria-associated control of cell proliferation and cellular metabolism, hence the label focused on both aspects.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":1},{"id":"GO:0070940","count":1},{"id":"GO:2000134","count":1},{"id":"GO:0046902","count":1},{"id":"GO:0010867","count":1}]},{"hash":"99914025530461072","title":"Plant gravitropism and plastid dynamics","description":"The cluster is characterized by GO terms related to gravity sensing and plastid organization (negative gravitropism, detection of gravity, amyloplast organization, plastid-related), along with regulation of mitochondrial fission, pointing to a cohesive theme of plant organelle dynamics underlying gravity response. Lipid droplet organization and triglyceride catabolic process suggest energy storage and mobilization associated with these organellar processes, while occasional immune-related terms appear more general rather than defining the cluster's function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090141","count":3},{"id":"GO:0009959","count":2},{"id":"GO:0034389","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0009590","count":2}]},{"hash":"1713917792444991068","title":"Cell signaling and cytoskeletal regulation","description":"The proteins cluster around diverse GO terms tied to signaling pathways (Rho/Ral, integrin, GH receptor, IGF receptor) and cytoskeletal processes (stress fiber assembly), with additional immune signaling (T cell receptor). Despite one outlier term (sensory perception of sound), the dominant theme is broad cell signaling and cytoskeletal dynamics, justifying the label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0048009","count":3},{"id":"GO:0007605","count":2},{"id":"GO:0032485","count":2},{"id":"GO:0051492","count":2}]},{"hash":"42825157819674135","title":"Innate Immune Signaling and Cytokine Production","description":"The top GO terms are dominated by innate immune pathways and cytokine production, including NOD2 signaling, cytokine and chemokine production, and immune response, suggesting the cluster reflects innate immune activation and inflammatory signaling. Other terms touch on endocytosis, Rho signaling, mechanical response, and myoblast fusion, but the strongest signal is immune-related, supporting a label of innate immune signaling with cytokine output.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":3},{"id":"GO:0048260","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0070431","count":2}]},{"hash":"1690760749919259354","title":"Immune signaling and inflammatory mediator production","description":"The GO terms show enrichment for regulation of lymphocyte activity (interleukin-2 production, T and B cell receptor signaling) and inflammatory mediator biosynthesis (leukotriene production, GM-CSF production), plus angiogenesis and cell\u2013cell adhesion linked to immune cell interactions. This points to a cohesive theme of immune signaling and production of inflammatory mediators, despite no reported edges among proteins.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900042","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0016337","count":2},{"id":"GO:0050860","count":2},{"id":"GO:0051092","count":2}]},{"hash":"2105643748053659119","title":"Unknown","description":"The GO terms are highly diverse, ranging from RNA processing and chromatin-related processes to lipid droplets, plant organ formation, protein folding, and host\u2013virus interactions, with several entries marked obsolete. There is no clear, shared function or pathway linking the proteins, and only a single low-degree edge, so a coherent label cannot be assigned.","confidence":"","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":2},{"id":"GO:0070481","count":2},{"id":"GO:0030466","count":2},{"id":"GO:0034389","count":1},{"id":"GO:0048453","count":1}]},{"hash":"2202356114157918843","title":"Amino acid and cofactor biosynthesis","description":"These proteins are enriched for biosynthetic processes of several amino acids (serine, threonine/alanine, lysine) and cofactors such as biotin, as well as a porphyrin precursor (protoporphyrinogen IX). The top GO terms cluster around amino acid biosynthesis and cofactor/porphyrin biosynthesis, indicating a metabolic synthesis role for the cluster. A few terms related to transport or structural organization appear weaker and do not define the core theme.","confidence":"High","size":6,"edges":10,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006564","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0019518","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0042853","count":2}]},{"hash":"2280840317014256931","title":"Retinal neuron guidance and synapse formation","description":"These proteins cluster around neuronal development and connectivity: axon guidance, axonal fasciculation, paranodal junction assembly, and synapse assembly. The retina-specific term camera-type eye photoreceptor cell differentiation further anchors the theme to retinal neuron development. Additional signaling terms (Notch signaling, receptor internalization) reflect regulation of these developmental processes, supporting a label focused on retinal neuron guidance and synapse formation.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":2},{"id":"GO:0007166","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007413","count":2}]},{"hash":"794607140167757658","title":"Cell adhesion and intercellular signaling","description":"This cluster\u2019s GO terms are dominated by adhesion and intercellular communication concepts (homophilic adhesion, intermicrovillar adhesion, endothelial barrier establishment, and Purkinje-cardiomyocyte adhesion), with supporting signals related to synaptic scaffolding and microvillus regulation. While some terms touch on pigment transport or immune differentiation, the common thread appears to be proteins involved in cell\u2013cell contacts and communication across tissues.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":6},{"id":"GO:0032912","count":6},{"id":"GO:0086073","count":6},{"id":"GO:1903142","count":6},{"id":"GO:0007156","count":6}]},{"hash":"736289073482046388","title":"Planar polarity and axon guidance with cell adhesion","description":"The cluster\u2019s GO terms cluster around planar polarity processes (establishment of planar polarity, receptor clustering, body hair orientation), axon guidance (serotonergic neuron axon guidance; planar polarity pathway involved in axon guidance), and cell\u2013cell adhesion (homophilic/heterophilic adhesion, leukocyte tethering or rolling). This points to a module coordinating tissue organization, neuronal wiring, and cell\u2013cell interactions during development, so the label Planar polarity and axon guidance with cell adhesion captures the main theme.","confidence":"High","size":6,"edges":7,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0050901","count":4},{"id":"GO:1904938","count":3},{"id":"GO:0036515","count":3},{"id":"GO:0060490","count":3},{"id":"GO:0007156","count":3}]},{"hash":"1901808940982991692","title":"Embryonic organogenesis across tissues","description":"The top GO terms point to broad embryonic development and organ formation across multiple tissues, including neural structures (metencephalon development, telencephalon regionalization, spinal cord neuron differentiation), heart development, endocrine pancreas development, and limb digit morphogenesis. Some terms relate to regulatory steps in development, reinforcing a cohesive theme of organismal formation during embryogenesis rather than a single pathway. This supports a label of embryonic organogenesis spanning multiple tissues. ","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":5},{"id":"GO:1902870","count":5},{"id":"GO:0042663","count":5},{"id":"GO:0002087","count":5},{"id":"GO:0021978","count":5}]},{"hash":"1877958849669155394","title":"Neuronal signaling and sensory development","description":"This cluster centers on neural signaling and sensory system formation, highlighted by GO terms for sodium ion transport, cellular response to electrical stimulus, receptor internalization, and development of anterior/posterior lateral line systems. While electron transport chain terms hint at metabolism, the dominant signal is neuronal excitability and sensory development.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0031623","count":5},{"id":"GO:0048169","count":5},{"id":"GO:0071257","count":5},{"id":"GO:0048915","count":5}]},{"hash":"1975311068311358417","title":"Developmental regulation and morphogenesis","description":"The top GO terms span development and morphogenesis across multiple tissues (gonads, nervous system, nephric duct, plant ovules) and include gene-expression control (miRNA silencing, RNA polymerase II transcription) and cytoskeletal remodeling (actin dynamics), suggesting a cohesive theme of how cells differentiate and shape tissues during development.","confidence":"High","size":6,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":6},{"id":"GO:2000637","count":6},{"id":"GO:0097067","count":6},{"id":"GO:0030835","count":6},{"id":"GO:0035995","count":6}]},{"hash":"329851759168526171","title":"Amino acid and fatty acid catabolism","description":"The dominant GO terms are L-leucine, L-valine, and L-alanine catabolic processes and fatty acid beta-oxidation, pointing to enzymes involved in breaking down amino acids and long-chain fatty acids. Redox homeostasis aligns with oxidative metabolism. Although two terms are obsolete, the core theme is amino acid and fatty acid degradation.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006552","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0051573","count":2},{"id":"GO:0042853","count":2}]},{"hash":"2039969833406293884","title":"Bacterial cell wall biosynthesis and division","description":"The terms focus on synthesis of cell wall components (peptidoglycan, lipoteichoic acid, dolichol-linked oligosaccharides), carbohydrate metabolism, and processes linked to cell cycle/division and cell shape, indicating a cohesive theme of cell wall biosynthesis coupled with cell division in bacteria.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009252","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0009247","count":2},{"id":"GO:0070395","count":2},{"id":"GO:0016999","count":2}]},{"hash":"1350178119854255794","title":"Bacterial lipid metabolism and amino acid catabolism","description":"This cluster centers on lipid-related metabolism: lipopolysaccharide biosynthesis, long-chain fatty acid catabolism, and beta-oxidation, plus leucine catabolic (amino acid) pathways. The presence of dephosphorylation and a cadmium transport term suggests additional general regulatory and membrane-associated processes, but the dominant theme tying the terms together is lipid metabolism and related catabolic pathways in bacteria. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:1904070","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0006552","count":1},{"id":"GO:0033539","count":1}]},{"hash":"1066753692169354757","title":"Unknown","description":"Top GO terms are a mix of immune signaling (pro-T cell differentiation, B cell receptor signaling, isotype switching regulation, mast cell cytokine production) and plant/kidney development terms (phototropism, gravitropism, distal tubule morphogenesis), with no clear shared function. The lack of connections (edges) among proteins further suggests there is no cohesive molecular theme linking them. This cluster cannot be confidently assigned a specific biological function.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000176","count":2},{"id":"GO:0072156","count":2},{"id":"GO:1900477","count":2},{"id":"GO:0045496","count":2},{"id":"GO:0050853","count":2}]},{"hash":"192761951431441557","title":"Ubiquitin-Proteasome Degradation","description":"The cluster is dominated by GO terms for ubiquitination and proteasome-dependent protein catabolic processes (SCF-dependent ubiquitin tagging, ubiquitin-dependent degradation, and protein ubiquitination), suggesting the proteins function in tagging substrates for proteasomal turnover. Some non-core terms appear, but the central theme is ubiquitin-mediated protein degradation and turnover.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":2},{"id":"GO:0000083","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0046328","count":2}]},{"hash":"1613930080041184131","title":"Embryonic development and morphogenesis","description":"The terms cluster around broad developmental and morphogenetic processes across multiple tissues (mesoderm, palate, hair follicle, pancreas, placenta) and EMT-related events, suggesting a general role in embryogenesis and tissue differentiation rather than a single pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0007498","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3}]},{"hash":"537981555756994062","title":"Lipid and sterol biosynthesis","description":"The top GO terms are dominated by lipid/sterol metabolism: unsaturated and monounsaturated fatty acid biosynthesis (GO:0006636, GO:1903966), ergosterol biosynthetic process and its regulation (GO:0032443, GO:0006675), and related lipid metabolic activity (GO:0006809, GO:0000001). While there are a few outliers (mitochondrion inheritance, nitric oxide biosynthesis), the shared theme across the majority of terms points to lipid and sterol biosynthesis as the core function of this cluster.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000001","count":6},{"id":"GO:0006675","count":6},{"id":"GO:0006809","count":6},{"id":"GO:0032286","count":6},{"id":"GO:0006636","count":6}]},{"hash":"403881152959210853","title":"Sperm chemotaxis and acrosome signaling","description":"The top GO terms concentrate on chemical sensing and reproductive signaling (response to pheromone, sensory perception of chemical stimulus) and specifically on regulation of the acrosome reaction, with supporting pathways in calcium signaling and phosphorylation, suggesting a module tied to sperm chemotaxis and fertilization processes, despite a few outlier terms.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0019236","count":2},{"id":"GO:0007606","count":2},{"id":"GO:0001558","count":1},{"id":"GO:0060046","count":1}]},{"hash":"2243558991280693079","title":"Steroid Hormone and Prostaglandin Metabolism","description":"Based on the GO terms, the cluster is centered on lipid-derived hormone biosynthesis and metabolism, with strong signals for prostaglandin production and steroid hormone pathways (androgen, progesterone, aldosterone) and related P450 activity. The other terms (stress response, endothelial adhesion, alkaloid metabolism) are present but secondary, not defining the core function. ","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":1},{"id":"GO:0097267","count":1},{"id":"GO:0033076","count":1},{"id":"GO:0008585","count":1},{"id":"GO:0035902","count":1}]},{"hash":"188853378526711348","title":"Developmental Signaling and Cytoskeletal Remodeling","description":"The cluster is enriched for signaling pathways (positive regulation of IL-2 production, cellular response to TGF-beta stimulus, insulin receptor signaling) and developmental processes (heart development, fusion cell fate specification), along with cytoskeletal/synaptic components (actin filament branching, postsynaptic density assembly). This points to a module where signaling cues coordinate development with cytoskeletal and synaptic remodeling, rather than a single discrete function.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0071560","count":3},{"id":"GO:1904424","count":3},{"id":"GO:0035156","count":3},{"id":"GO:0090135","count":3}]},{"hash":"166383809705792524","title":"Developmental transcriptional regulation","description":"This cluster centers on negative regulation of transcription by RNA polymerase II along with a range of developmental processes across neural, facial, cardiac, pancreatic, and spinal tissues, suggesting proteins involved in controlling gene expression during embryonic development rather than a single pathway.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0060021","count":6},{"id":"GO:0022037","count":5},{"id":"GO:1902870","count":5},{"id":"GO:0042663","count":5}]},{"hash":"594171607420805280","title":"Unknown","description":"The Top Terms are diverse, spanning mRNA splicing, membrane transport, several signaling pathways, and ergothioneine/selenoneine biosynthesis, with no clear shared function. Because there is no coherent theme or interaction pattern linking these terms, this cluster cannot be confidently assigned a single biological role.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:1902306","count":1},{"id":"GO:0048227","count":1},{"id":"GO:1902072","count":1},{"id":"GO:0033209","count":1}]},{"hash":"1808817260571272237","title":"Insulin/IGF signaling and fatty acid metabolism","description":"The top GO terms cluster around insulin receptor signaling, IGF receptor signaling, glycogen biosynthesis, and regulation of fatty acid beta-oxidation and fatty acid import, suggesting a metabolic program controlled by insulin/IGF pathways with lipid and carbohydrate metabolism implications (and some heart-related terms).","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0032000","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0010748","count":4}]},{"hash":"1254823333786403531","title":"Neural signaling and brain behavior","description":"The top GO terms are dominated by neural processes: visual perception and learning, dopaminergic synaptic transmission, behavioral response to cocaine, and ERK1/2 signaling, all central to brain function. While a few terms touch on non-neural areas (heart development, macrophage chemotaxis, brain RAS), the core set points to neuronal signaling and brain-driven behavior.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0001963","count":6},{"id":"GO:0048148","count":6},{"id":"GO:0071380","count":6}]},{"hash":"296421955887828573","title":"Diverse solute transporters","description":"The top GO terms point to transmembrane transport of a variety of substrates\u2014nitrite, nitrate, sodium ions, sugars (arabinose), sialic acid, phosphate, 4-hydroxyphenylacetate, and xenobiotics\u2014as well as neurotransmitter loading into synaptic vesicles. This pattern indicates membrane transporter proteins with broad substrate specificity rather than a single substrate function. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0015751","count":1},{"id":"GO:0015739","count":1},{"id":"GO:0035435","count":1}]},{"hash":"2142621984347291916","title":"Cardiac and skeletal muscle development with Wnt signaling","description":"The set is dominated by terms tied to heart formation and skeletal muscle differentiation, with a notable emphasis on negative regulation of canonical Wnt signaling, suggesting roles in developmental patterning and tissue specification. Additional terms point to broad regulatory and nuclear processes (protein export from nucleus, nuclear envelope dynamics, angiogenesis), which commonly accompany organogenesis and muscle/heart development. Overall, these proteins likely participate in orchestrating cardiac and skeletal muscle development while modulating key signaling pathways.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":3},{"id":"GO:0045950","count":3},{"id":"GO:0046827","count":3},{"id":"GO:0051898","count":3},{"id":"GO:0060914","count":3}]},{"hash":"18401807084480647","title":"Embryonic endoderm and heart development signaling","description":"The terms clustered here center on embryonic development, with emphasis on endodermal fate specification, heart morphogenesis, and related signaling pathways (Notch and SMAD), plus placenta development. This suggests a cohesive theme of developmental signaling guiding endoderm and cardiac organogenesis.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001714","count":2},{"id":"GO:0060395","count":2},{"id":"GO:0003007","count":2},{"id":"GO:0032212","count":1},{"id":"GO:0001890","count":1}]},{"hash":"886510684024844393","title":"Neuronal signaling and lipid transport","description":"Dominant terms point to neural signaling and nervous system development, including dopaminergic synaptic transmission and GPCR opioid receptor signaling, with lipid transport supporting membrane processes. Some terms (ergosterol biosynthesis, digestion, stress-related glucocorticoid biosynthesis) appear less connected, indicating noise but not overturning the central theme of neural signaling and membrane lipid biology.","confidence":"Medium","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006869","count":3},{"id":"GO:0043523","count":3},{"id":"GO:0070207","count":3},{"id":"GO:0038003","count":3},{"id":"GO:0007399","count":3}]},{"hash":"2092848477785796662","title":"SNARE-Mediated Vesicle Trafficking","description":"The top GO terms cluster around vesicle transport and membrane fusion, especially SNARE complex assembly, ER-Golgi and Golgi-endosome/retrograde pathways, and general protein transport. This points to a shared role in vesicle docking/fusion and secretory traffic, with degranulation terms reflecting secretory granule release seen in immune cells. Positive regulation of dendrite morphogenesis appears less central to core trafficking, likely a peripheral annotation. ","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042144","count":2},{"id":"GO:0006890","count":1},{"id":"GO:0043320","count":1},{"id":"GO:0035493","count":1},{"id":"GO:0006888","count":1}]},{"hash":"1205685123797915897","title":"Keratinization and Hair Cycle","description":"The GO terms show keratinization and hair cycle as dominant themes, pointing to proteins involved in epidermal keratinization and hair follicle cycling. The cluster likely groups keratins and related structural or regulatory factors coordinating hair shaft formation and the hair growth phases.","confidence":"High","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":6},{"id":"GO:0042633","count":6}]},{"hash":"1402002727434762628","title":"Chromatin Organization and Nucleosome Assembly","description":"This cluster centers on chromatin-related processes, with dominant GO terms for nucleosome assembly, histone methylation, and heterochromatin organization, indicating proteins involved in chromatin packaging, modification, and nuclear localization to chromatin.","confidence":"High","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":5},{"id":"GO:0098532","count":5},{"id":"GO:0080182","count":5},{"id":"GO:0071169","count":5},{"id":"GO:0097298","count":5}]},{"hash":"309099951144858106","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001160","count":1},{"id":"GO:0010964","count":1},{"id":"GO:0051571","count":1},{"id":"GO:0009910","count":1},{"id":"GO:0031126","count":1}]},{"hash":"1235212453573737228","title":"Unknown","description":"The terms cover diverse processes\u2014from insect wing/eye development and signaling to protein processing, unfolded protein response, spermatid differentiation, immune regulation, and various transport activities\u2014without a single unifying function.","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035311","count":3},{"id":"GO:0042676","count":3},{"id":"GO:0038005","count":3},{"id":"GO:1904211","count":3},{"id":"GO:0034620","count":3}]},{"hash":"2145286443257346938","title":"Meiosis and gamete formation","description":"These proteins are annotated with multiple meiotic processes including sister chromatid cohesion, chromosome condensation, synaptonemal complex assembly, and oocyte maturation, as well as fertilization, which together point to meiotic gamete development.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010789","count":1},{"id":"GO:0001556","count":1},{"id":"GO:0003187","count":1},{"id":"GO:1990414","count":1},{"id":"GO:0045876","count":1}]},{"hash":"1463263648142345659","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":2},{"id":"GO:1903026","count":2},{"id":"GO:0009845","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0000387","count":2}]},{"hash":"1508232843416139335","title":"RNA processing and gene silencing","description":"This cluster is enriched for RNA metabolism and RNA-mediated silencing terms: splicing, export, stabilization, regulatory ncRNA- and miRNA-mediated silencing. Additional terms about translation initiation, ubiquitination, circadian regulation, and development are present but less dominant, so the core theme is post-transcriptional RNA regulation and gene silencing.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0075522","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0071600","count":1},{"id":"GO:0008380","count":1}]},{"hash":"1926978742030857665","title":"Mitochondrial lipid biosynthesis and remodeling","description":"This cluster is dominated by GO terms for lipid production and remodeling (phosphatidylcholine, cardiolipin, triglycerides, ether lipids, platelet activating factor) and by mitochondrial energy metabolism (mitochondrial ATP synthesis coupled electron transport), suggesting a cohesive module of lipid biosynthesis tied to mitochondrial membrane function.","confidence":"High","size":6,"edges":9,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":5},{"id":"GO:0010143","count":5},{"id":"GO:2001246","count":5},{"id":"GO:0035965","count":5},{"id":"GO:0036151","count":5}]},{"hash":"674733091212708437","title":"Craniofacial development and body patterning","description":"The top GO terms are dominated by developmental processes such as skeletal system development, roof of mouth development, olfactory bulb development, visceral motor neuron differentiation, and left-right pattern formation. These indicate a cluster centered on morphogenesis and craniofacial/body patterning, with additional signals related to endocrine regulation of development and other regulatory processes. This supports a coherent though not perfectly uniform theme around developmental patterning and craniofacial formation, hence the chosen label. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090334","count":2},{"id":"GO:0097067","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0021524","count":2},{"id":"GO:0060021","count":2}]},{"hash":"865015782669964588","title":"ER Stress, Protein Folding, and Innate Immunity","description":"The top GO terms cluster around unfolded protein response, ER-associated degradation, chaperone activity, and translation regulation in response to ER stress, plus innate immune and antiviral defense. This suggests a functional group focused on ER quality control and stress response with links to innate immunity. Some terms are obsolete, but the core theme remains ER-related protein folding and immune signaling.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0006986","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0045842","count":3},{"id":"GO:0051607","count":3}]},{"hash":"1640465773559502705","title":"Zinc ion transport and homeostasis","description":"The top terms cluster around zinc handling: import and intracellular homeostasis of zinc, response to zinc ion starvation, and detoxification, with a note of cadmium ion transport as related metal handling. A minor limb development signal appears but does not define the cluster\u2019s function. ","confidence":"High","size":6,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006882","count":3},{"id":"GO:0006830","count":3},{"id":"GO:0034224","count":3},{"id":"GO:0044749","count":3},{"id":"GO:1903615","count":3}]},{"hash":"2000943494377980154","title":"Zinc Ion Transport and Homeostasis","description":"The cluster\u2019s GO terms overwhelmingly center on zinc import across membranes, intracellular zinc ion homeostasis, detoxification of zinc, and cellular responses to zinc ion availability, with an additional related term for cadmium transport. While a couple of terms (nuclear membrane organization and limb development) are less directly connected, the dominant pattern clearly points to zinc ion transport and homeostasis as the shared function.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071763","count":1},{"id":"GO:0006882","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0034224","count":1},{"id":"GO:0044749","count":1}]},{"hash":"2226247177985258114","title":"Neuronal adrenergic and dopaminergic signaling","description":"The terms show a strong focus on brain GPCR signaling driven by adrenergic and dopaminergic pathways: brain renin-angiotensin system, dopaminergic synaptic transmission, adrenergic receptor\u2013mediated MAPK and phospholipase C signaling, and norepinephrine-epinephrine\u2013related vasoconstriction. Minor entries like thymocyte differentiation and opioid receptor signaling are less central but may reflect broader signaling roles. Overall, the cluster centers on neuronal adrenergic/dopaminergic signaling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":5},{"id":"GO:0001963","count":5},{"id":"GO:1900453","count":5},{"id":"GO:0001994","count":5},{"id":"GO:0071883","count":5}]},{"hash":"1715147016497723571","title":"Protein Localization and Stress Response Regulators","description":"The terms cluster around regulation and trafficking of proteins to specific compartments (mitochondrial intermembrane space, telomeres, Cajal bodies, host cytoplasm) and include stress/immune-related responses (heat, cadmium, cocaine, T cell\u2013mediated tumor response, IgG isotype switching), suggesting a shared theme of localization control intertwined with stress and immune signaling.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":5},{"id":"GO:0002842","count":5},{"id":"GO:0044053","count":5},{"id":"GO:0046686","count":5},{"id":"GO:0045041","count":5}]},{"hash":"435011658702448096","title":"Amino acid and ion transporters","description":"These proteins show enrichment for transmembrane transport of amino acids (GABA, L-ornithine, D-alanine, D-serine) and ions (ammonium, rubidium), plus related cell-volume and transepithelial transport terms, with a few macrophage activation and nitric oxide\u2013related inflammatory terms. The coherence lies in membrane transporter function, particularly amino acid/ion transport, with a possible secondary link to inflammation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043030","count":1},{"id":"GO:0015812","count":1},{"id":"GO:0097640","count":1},{"id":"GO:0042941","count":1},{"id":"GO:0035826","count":1}]},{"hash":"1648006878806289965","title":"Wound Healing and Immune Cell Trafficking","description":"The terms cluster around tissue repair and immune cell recruitment, including wound healing, regulation of NK and T cell chemotaxis, leukocyte adhesion, and integrin activation. Additional terms reflect inflammatory signaling (TNF, TGF-beta) and lipid-responsive responses, all pointing to coordinated immune involvement in wound repair and remodeling. This theme cohesively explains the GO terms shown.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0042060","count":3},{"id":"GO:2000502","count":3},{"id":"GO:0060325","count":2},{"id":"GO:0050902","count":2},{"id":"GO:0033625","count":2}]},{"hash":"1523007187452295114","title":"Unknown","description":"The GO terms are scattered across DNA replication, membrane targeting, iron-sulfur cluster assembly, and various negative regulatory processes, with several obsolete entries; there is no single unifying function linking these proteins, and the cluster has minimal connectivity, so a confident, specific label cannot be assigned.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070389","count":5},{"id":"GO:0006260","count":5},{"id":"GO:0031204","count":3},{"id":"GO:0016226","count":3},{"id":"GO:0006880","count":3}]},{"hash":"907876436246375766","title":"Cell Cycle and Division Proteins","description":"The top GO terms show strong enrichment for cell division and cell cycle-related processes (GO:0051301, GO:0007049, GO:0000278), indicating a core theme of proliferative/cell-cycle functions. Additional terms point to innate immune and dsRNA responses, suggesting possible multifunctionality, but the dominant signal aligns with cell-cycle progression. Overall, the cluster appears best described as cell cycle/division\u2013related proteins, with peripheral associations to other processes. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0045087","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0006478","count":2},{"id":"GO:1903646","count":2}]},{"hash":"1761615759588261870","title":"Fatty acid metabolism and adipose development","description":"This cluster is dominated by GO terms for fatty acid beta-oxidation, acetyl-CoA catabolic processes, propionyl-CoA biosynthesis, and adipose tissue development, pointing to a cohesive role in lipid metabolism and energy handling in adipose tissue. Additional signals for lipid transport and hormone response support a metabolic/adipose-specific theme, with protein homooligomerization as a common structural feature among metabolic enzymes.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":4},{"id":"GO:0032385","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0014070","count":4},{"id":"GO:0046356","count":4}]},{"hash":"720686397607866973","title":"Energy metabolism and redox homeostasis","description":"The top GO terms cluster around core energy pathways (glycolysis and TCA cycle) and redox balance (oxidation\u2013reduction, redox homeostasis), with related metabolic processes and xenobiotic response, suggesting a coherent theme of energy production and redox regulation rather than a single narrow function.","confidence":"High","size":5,"edges":8,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006099","count":3},{"id":"GO:0042493","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0006541","count":2}]},{"hash":"2158064982699110291","title":"Cardiovascular development and signaling","description":"The GO terms cluster around heart-related processes (Purkinje-to-ventricular signaling, regulation of atrial depolarization, endothelial cell delamination) and multicellular development with transcriptional activity, suggesting a developmental/cardiovascular function theme. Some terms like skin development and aldosterone biosynthesis are present but are less central to the core signal, so the label emphasizes cardiovascular development and signaling.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0097497","count":3}]},{"hash":"241897746208780290","title":"ECM Organization and Signaling Proteins","description":"Based on the top GO terms, this cluster centers on extracellular matrix organization and cell-matrix adhesion (collagen fibril organization, adhesion) but also includes signaling-related terms (TLR4 signaling, NF-kappaB regulation) and structural development processes (axon extension, sarcomere organization). The mix suggests proteins involved in ECM remodeling alongside diverse signaling and developmental roles rather than a single cohesive function. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0034142","count":2},{"id":"GO:0048675","count":2},{"id":"GO:0061097","count":2}]},{"hash":"1421381128337886883","title":"Growth signaling and cell cycle regulation","description":"The Top Terms show emphasis on TORC1 signaling (growth control) and cell cycle processes (mitosis, checkpoints), plus chromatin organization and differentiation (osteoblast differentiation, histone acetylation). This suggests a cluster tied to growth signaling and transcriptional programs governing cell cycle and differentiation, with chromatin regulation contributing to gene expression; occasional unrelated terms (taste perception) appear as noise. Confidence: Medium","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:1904263","count":5},{"id":"GO:0030433","count":4},{"id":"GO:1901976","count":4},{"id":"GO:0071560","count":4},{"id":"GO:0051260","count":4}]},{"hash":"486920824110840984","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002188","count":2},{"id":"GO:0000724","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0006293","count":2}]},{"hash":"1343522987489109885","title":"Mitochondrial Metabolite Transport","description":"The proteins cluster around transmembrane transport of various metabolites (NAD, glycine, ornithine, thiamine pyrophosphate, deoxynucleotides) and include functions related to mitochondrial membrane fission and permeability, which points to a core role in mitochondrial transport and membrane remodeling. The presence of broader context terms like amino acid starvation response and liver regeneration suggests these transport processes are linked to metabolic stress responses and energy metabolism in mitochondria, reinforcing the theme. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035352","count":3},{"id":"GO:0034198","count":3},{"id":"GO:0000066","count":3},{"id":"GO:0097421","count":3},{"id":"GO:0036233","count":3}]},{"hash":"2247417572340631699","title":"Unknown","description":"The top terms span very diverse processes (cell division, ribosome biogenesis, metal ion transport, small GTPase signaling, stress responses, and glial proliferation) with no clear, single function tying the proteins together. This makes it hard to assign a cohesive label that accurately represents the cluster\u2019s biology. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006777","count":2},{"id":"GO:1901001","count":2},{"id":"GO:0014009","count":2},{"id":"GO:0000288","count":2}]},{"hash":"538465813069727318","title":"Amino acid and small-molecule metabolism","description":"The GO terms point to a mix of catabolic and biosynthetic pathways across amino acids (valine, methionine, taurine) and other small molecules (thiamine, phylloquinone), plus fermentation processes like pyruvate to ethanol. This suggests a cluster tied to diverse metabolic transformations of small molecules rather than a single, cohesive pathway, focusing on broad metabolic capabilities.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000951","count":2},{"id":"GO:0000950","count":2},{"id":"GO:0019655","count":2},{"id":"GO:0090180","count":2},{"id":"GO:0019310","count":2}]},{"hash":"1546630457282826194","title":"NF-kappaB-Driven Immune Signaling","description":"The top terms center on positive regulation of NF-kappaB activity and NF-kappaB signaling, with a notable item on dendritic cell differentiation, pointing to an immune signaling theme. While a few terms pertain to neuronal or plant processes, the dominant immune-related terms suggest a shared function in NF-kappaB\u2013mediated immune signaling and dendritic cell biology.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0043123","count":2},{"id":"GO:2001200","count":2},{"id":"GO:0021814","count":1},{"id":"GO:0090332","count":1}]},{"hash":"296871164927975124","title":"Multifunctional signaling and differentiation","description":"This cluster spans a broad mix of GO terms, including telomere maintenance, vascular dynamics, innate immune signaling, cytokine regulation, sensory perception, cell growth, muscle stretch response, adipocyte differentiation, SNARE complex regulation, and PARP-mediated protein modification. There isn\u2019t a single cohesive function that dominates; the terms point to diverse signaling, growth, and differentiation roles across multiple tissues. Therefore the label reflects a general theme of multifunctional signaling and differentiation rather than a specific pathway. ","confidence":"Low","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":1},{"id":"GO:0097497","count":1},{"id":"GO:0070431","count":1},{"id":"GO:0045083","count":1},{"id":"GO:0050968","count":1}]},{"hash":"1137539525197083757","title":"Neural and Vascular Development","description":"This cluster is enriched for axon guidance (retinal ganglion, motor neuron) and angiogenesis-related terms (sprouting angiogenesis, endothelial cell migration, angiogenesis), suggesting a shared role in coordinated neural and vascular development and tissue remodeling. Additional terms on synapse assembly and integrin-mediated adhesion support neuronal connectivity and cell\u2013matrix interactions, while a few outliers like bone remodeling and mammary gland proliferation reflect broader developmental processes but do not override the central theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031290","count":3},{"id":"GO:0008045","count":3},{"id":"GO:0002042","count":3},{"id":"GO:0046849","count":3},{"id":"GO:0051965","count":3}]},{"hash":"1761388762133629161","title":"ER-Golgi Trafficking and Membrane Organization","description":"Based on the top GO terms, the cluster centers on processes related to membrane trafficking and organization of protein traffic through the ER and Golgi, including ER membrane fusion and Golgi organization, as well as protein localization to the plasma membrane. Additional terms touch on membrane-associated processes (synaptic assembly, cell adhesion) and, more broadly, immune signaling, suggesting a membrane/secretory context with some functional diversity rather than a single tight pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900025","count":1},{"id":"GO:0050860","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0016320","count":1},{"id":"GO:0071158","count":1}]},{"hash":"2194448155276324669","title":"Unknown","description":"The proteins show a highly diverse set of GO terms (ERAD-related, protein processing, vesicle transport, metabolism, metal ion transport, RNA export, DNA replication), with several terms obsolete. There isn\u2019t a clear overarching function linking these annotations, suggesting either heterogeneous roles or noisy clustering. ","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0071712","count":2},{"id":"GO:0042760","count":1},{"id":"GO:0048219","count":1},{"id":"GO:0030433","count":1}]},{"hash":"635974568063880936","title":"Innate Immunity and Translational Control","description":"These proteins show enrichment for innate immune response, antiviral regulation, and stress-linked translational control (eIF2\u03b1 phosphorylation) along with mRNA processing and regulatory aspects; together they suggest a host defense and stress response module. Some terms appear obsolete or noisy, but the core theme centers on immune defense and translation regulation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033160","count":3},{"id":"GO:0009636","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0010998","count":3}]},{"hash":"2169637041636267439","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070932","count":2},{"id":"GO:0034476","count":1},{"id":"GO:1990414","count":1},{"id":"GO:1903608","count":1},{"id":"GO:0006306","count":1}]},{"hash":"2204163577521468519","title":"Cell division and chromatin regulation","description":"Most terms point to mitosis and cell cycle control (cell division, mitotic cell cycle, regulation of cell cycle checkpoint) and to chromatin dynamics (chromatin organization, histone acetylation, protein homooligomerization), with some regulatory notes (ubiquitin-dependent ERAD pathway, TGF-beta response) and a few odd terms likely representing noise (taste perception). This supports a cohesive theme around cell-cycle progression and chromatin state.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0000920","count":5},{"id":"GO:0030433","count":4},{"id":"GO:1901976","count":4},{"id":"GO:0071560","count":4}]},{"hash":"751028877656960255","title":"Protein ubiquitination and ERAD quality control","description":"This cluster is dominated by GO terms for ubiquitination (polyubiquitination, K63-linked ubiquitination, autoubiquitination) and the ubiquitin-dependent ERAD pathway, plus chaperone-mediated assembly, pointing to a cohesive theme of protein quality control and degradation. A couple of terms related to apoptosis and heart morphogenesis appear incidental and do not undermine the central ubiquitination-focused signal.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0090035","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0003222","count":2}]},{"hash":"404279240828926967","title":"Nucleotide Metabolism and Salvage","description":"The top GO terms cluster around nucleotide phosphorylation and biosynthesis (nucleoside monophosphate phosphorylation, ADP/AMP/CDP biosynthesis, ITP metabolic process, AMP salvage, dephosphorylation), indicating a group of proteins involved in maintaining nucleotide pools and phosphate turnover. The presence of brain development among the annotations may reflect tissue-specific expression or annotation bias, but the dominant signal is nucleotide metabolism.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0046940","count":4},{"id":"GO:0016311","count":4},{"id":"GO:0015937","count":4},{"id":"GO:0046041","count":4}]},{"hash":"230112457489096966","title":"Membrane Trafficking and Rap Signaling","description":"The top GO terms cluster around transport between Golgi, plasma membrane, and endosomes, along with Rap protein\u2013mediated signal transduction and regulation of kinase activity, indicating a core function in vesicular trafficking tied to signaling pathways. Some peripheral terms reflect broader annotations, but the dominant theme points to trafficking plus signaling.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097327","count":5},{"id":"GO:0048227","count":5},{"id":"GO:0000001","count":5},{"id":"GO:0045859","count":5},{"id":"GO:0000186","count":5}]},{"hash":"1992469679160303184","title":"Mitochondrial energy metabolism and fatty acid oxidation","description":"The cluster shows strong signals for mitochondrial processes: electron transport (NADH to ubiquinone), Complex II assembly, mitochondrial translation, and multiple fatty acid pathways (long-chain/medium-chain fatty acid transport, carnitine metabolism, and beta-oxidation). Together these point to mitochondria-driven energy production and lipid catabolism; the ovarian follicle growth term appears ancillary. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":1},{"id":"GO:0034553","count":1},{"id":"GO:0001547","count":1},{"id":"GO:0015909","count":1},{"id":"GO:0051791","count":1}]},{"hash":"2119929006605863652","title":"Unknown","description":"The terms are too diverse to define a single cohesive function for the cluster. They include heart development, apoptosis regulation, mechanical stimulus response, IL-8 production, molybdenum cofactor biosynthesis, and clustering of GABA/glycine receptors, which do not point to a shared biological process or pathway among the proteins. This suggests the cluster does not represent a clear, unified function. ","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0032757","count":2},{"id":"GO:0006777","count":2}]},{"hash":"1211517311756039764","title":"Membrane trafficking and signaling","description":"This cluster shows enrichment for endomembrane transport terms (plasma membrane\u2013endosome, Golgi\u2013plasma membrane) and signaling-related terms (Rap signaling, regulation of protein kinase activity, MAPKK activity), suggesting a module of proteins involved in vesicle trafficking coupled to signal transduction. Some terms (mitochondrion inheritance, lymphocyte aggregation, oligodendrocyte differentiation) are more peripheral, but the core theme appears to be membrane trafficking with signaling. ","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097327","count":5},{"id":"GO:0048227","count":5},{"id":"GO:0000001","count":5},{"id":"GO:0045859","count":5},{"id":"GO:0000186","count":5}]},{"hash":"405381712133793100","title":"Innate immune response and xenophagy","description":"The top GO terms cluster around innate immunity, including innate immune response, response to dsRNA, defense against Gram-positive bacteria, and positive regulation of xenophagy, suggesting a group of proteins involved in pathogen recognition and autophagy-mediated defense. Supporting terms like NF-kappaB regulation reinforce a signaling role in immune activation, though some development-related terms appear incidental. Overall, the central theme is innate immune defense with autophagy involvement.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0043330","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0046641","count":3}]},{"hash":"985540000342801419","title":"Signaling and endomembrane transport","description":"The terms cluster around intracellular signaling (Rap signaling, regulation of kinase activity, MAPKK activity, NF-kappaB regulation) and membrane trafficking between the plasma membrane and endosomes, suggesting a theme of cellular signaling coupled with vesicle transport, despite a few outliers.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0097327","count":4},{"id":"GO:0048227","count":4},{"id":"GO:0000001","count":4},{"id":"GO:0045859","count":4},{"id":"GO:0000186","count":4}]},{"hash":"835702340466837232","title":"Mammary gland development and immune signaling","description":"The top GO terms point to mammary gland alveolus development and epithelial proliferation, alongside immune-related terms such as humoral response, IL-6 regulation, T cell chemotaxis, Gram-positive defense, and nitric oxide production, suggesting a functional module that links mammary tissue development with immune/inflammatory signaling. While both developmental and immune terms are present, there is no single dominant function, so this label emphasizes the dual aspects.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045994","count":3},{"id":"GO:0060749","count":3},{"id":"GO:0006959","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0045429","count":2}]},{"hash":"115816430503154918","title":"Wing disc morphogenesis and TOR signaling","description":"The term GO:0007472 (wing disc morphogenesis) together with GO:0007275 (multicellular organism development) and GO:0031929 (TOR signaling) point to a developmental program in Drosophila wing tissue that is integrated with growth regulation. Additional terms about signal transduction regulation and membrane localization support a theme of coordinated signaling and spatial organization during development, rather than a single biochemical activity. Confidence in this labeling is Medium.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0035308","count":1},{"id":"GO:0007472","count":1},{"id":"GO:0031929","count":1},{"id":"GO:0009966","count":1}]},{"hash":"2029869505090236610","title":"Actin dynamics in muscle and immune cells","description":"The top GO terms point to actin filament dynamics (polymerization, movement) and skeletal muscle contraction, with regulatory links to calcium signaling and immune cell functions (T cell antigen processing, lymphocyte migration). This suggests a theme of actin cytoskeleton remodeling coupled to calcium signaling in both muscle and immune contexts.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003009","count":1},{"id":"GO:0000188","count":1},{"id":"GO:0030041","count":1},{"id":"GO:0002625","count":1},{"id":"GO:1900028","count":1}]},{"hash":"58504227339437494","title":"Unknown","description":"The GO terms span diverse processes (intestinal glucose absorption, IL-2 production, synaptic inhibition, bone mineralization, dynein-driven meiotic movement, heart and vagus nerve development, vulval development, Wnt signaling, prepulse inhibition); no single shared function or pathway ties them together, and with only 5 proteins and no edges the cluster lacks a cohesive theme. Therefore a specific, meaningful label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001951","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0016201","count":2},{"id":"GO:0030282","count":2},{"id":"GO:0030989","count":2}]},{"hash":"650443785675409416","title":"Interferon-driven mucosal innate immunity","description":"The top GO terms cluster around innate immune response in mucosal tissues, antiviral defense, and type I interferon production, indicating a mucosal innate immune program with interferon signaling as a central theme. Some adhesion terms are present but the dominant function appears to be antiviral/mucosal immune activity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048873","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0007156","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0032733","count":1}]},{"hash":"1924979304468187938","title":"Immune activation and regulation (innate and adaptive)","description":"The top GO terms point to both innate and adaptive immune responses, including T and B cell regulation, IL-2 production, NK cell modulation, and peptidoglycan detection, suggesting a cluster of proteins involved in immune signaling and lymphocyte activation/modulation rather than a single specialized function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:2000649","count":2},{"id":"GO:0002250","count":2},{"id":"GO:0046007","count":2},{"id":"GO:0043066","count":1}]},{"hash":"87207938303395860","title":"Ribosome maturation and RNA modification","description":"The cluster is driven by translation and ribosomal RNA processing/modification terms (translation, maturation of SSU-rRNA, rRNA and tRNA methylation), indicating involvement in ribosome biogenesis and RNA modification. A few mitochondrial transcription terms suggest a mitochondria-related context but overall the common theme centers on ribosome function and RNA chemistry.","confidence":"Medium","size":5,"edges":8,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0031564","count":1},{"id":"GO:0006479","count":1},{"id":"GO:0006391","count":1}]},{"hash":"1280618970657577461","title":"Protein post-translational modifications and quality control","description":"The top terms cluster around diverse protein modification processes (sumoylation, ufmylation, urmylation, lipidation) and protein quality-control pathways (mitochondrial autophagy/nucleophagy, proteasomal regulation), with related functions in RNA modification and cell-cycle control. This suggests a cohesive theme of how cells modify proteins and manage their turnover to maintain proteostasis, hence the label focusing on PTMs and quality control.","confidence":"Medium","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000422","count":4},{"id":"GO:0016925","count":3},{"id":"GO:1901799","count":3},{"id":"GO:2000134","count":3},{"id":"GO:1990592","count":2}]},{"hash":"1055390809312276113","title":"RNA Processing in Drosophila Oogenesis","description":"Top terms show tRNA processing and mRNA processing as the strongest signals, with two proteins linked to each, suggesting a core RNA-maturation function. Several Drosophila oogenesis-related terms (egg chamber formation, germarium-derived development, and mRNA localization) imply the RNA-processing activities are connected to egg development. While ubiquitin-dependent pathways and endocytosis are also present, they are less represented; overall the RNA-processing theme is the dominant signal, giving a Medium confidence.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061587","count":2},{"id":"GO:0008033","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0030713","count":1},{"id":"GO:0048803","count":1}]},{"hash":"1746507407947951941","title":"Potassium Ion Homeostasis and Membrane Potential","description":"The terms cluster around maintaining intracellular potassium levels and transport across the plasma membrane, including import/export and stabilization of membrane potential, pointing to a function in potassium balance and electrical potential maintenance. A few ancillary terms (Wnt signaling, Rho regulation, endothelial delamination) are present but do not outweigh the potassium-focused theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":3},{"id":"GO:0097623","count":3},{"id":"GO:0030322","count":3},{"id":"GO:1990573","count":3},{"id":"GO:0097497","count":2}]},{"hash":"1749314674311954275","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by terms tied to ribosome function and assembly\u2014translation, ribosome biogenesis, and ribosomal subunit assembly, along with maintenance/positive regulation of translational fidelity\u2014suggesting proteins focus on ribosome production and accurate protein synthesis. A few terms point to secondary responses (antibiotic response, interleukin-4 signaling) but do not overshadow the ribosome-focused signal.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0046677","count":2},{"id":"GO:0000448","count":1},{"id":"GO:0042255","count":1},{"id":"GO:0071353","count":1}]},{"hash":"1886131919311398368","title":"Aminoacyl-tRNA charging and translation","description":"Most terms cluster around tRNA aminoacylation (glutamyl-, glutaminyl-, prolyl-tRNA) and translation, with additional but minor references to brain development and immune signaling. The core signal points to the protein synthesis machinery, particularly tRNA charging enzymes feeding translation, making this a concise descriptor of the cluster\u2019s primary function.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006424","count":1},{"id":"GO:0006400","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006425","count":1}]},{"hash":"1080024103523547852","title":"Proteostasis and ER quality control","description":"The top GO terms cluster around nuclear protein quality control via the ubiquitin-proteasome system, ubiquitin-dependent ERAD, ER stress\u2013driven translation regulation, heat response, and protein targeting/trafficking. Together they point to a coherent proteostasis program maintaining protein folding, degradation, and trafficking in the nucleus and ER, fitting a proteostasis-focused cluster.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071630","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006452","count":2},{"id":"GO:0070389","count":2},{"id":"GO:0009408","count":2}]},{"hash":"539736660245620536","title":"Ubiquitin-Dependent Degradation and TNF/JNK Signaling","description":"This cluster is dominated by GO terms tied to ubiquitin-mediated proteolysis (ubiquitin-dependent protein catabolic processes, autoubiquitination, ERAD) and modulation of inflammatory signaling pathways (regulation of JNK cascade, TNF-mediated signaling, and positive regulation of TNF signaling). A fewer-term note on receptor turnover (Wnt receptor catabolic process) also aligns with catabolic themes. Together, these terms suggest a cohesive function around protein turnover through ubiquitination with links to inflammatory signaling pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0030433","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0051865","count":2}]},{"hash":"487956140445036589","title":"Diverse Metabolic Pathways","description":"The GO terms indicate involvement in multiple metabolic routes, including antibiotic biosynthesis, menaquinone and fatty acid metabolism, amino acid and nucleotide catabolism, and general phosphorylation regulation. The proteins thus appear to be a loosely connected set of enzymes participating in broad metabolic processes rather than a single, cohesive pathway.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006195","count":2}]},{"hash":"342730560321095655","title":"Neurodevelopmental brain region patterning","description":"This cluster centers on neural development and brain regional formation, with terms for pituitary gland development, telencephalon and metencephalon development, and amacrine cell differentiation. Regulatory processes (transcriptional control by RNA Pol II, miRNA-mediated gene silencing) and cytoskeletal dynamics (actin filament regulation) further support neurodevelopment and morphogenesis. A few terms are less directly tied (e.g., light-response), but the dominant theme is neural development and brain patterning.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0010201","count":2},{"id":"GO:0022037","count":2},{"id":"GO:1902870","count":2}]},{"hash":"1114596681421829087","title":"Neural development and stem cell maintenance","description":"The top GO terms center on neural development and synaptic processes, with entries for peripheral nervous system neuron development, cell fate determination, and somatic stem cell maintenance. Additional terms span other tissue differentiations, indicating a broad developmental regulatory role with a notable emphasis on neural differentiation and stem cell maintenance.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007274","count":2},{"id":"GO:2000382","count":2},{"id":"GO:0001709","count":2},{"id":"GO:0060762","count":2},{"id":"GO:0050860","count":2}]},{"hash":"268768191076654202","title":"Bacterial cell wall biosynthesis and antibiotic metabolism","description":"Based on the top GO terms, the cluster is dominated by biosynthetic processes related to cell wall components (lipoteichoic acid biosynthesis, cell wall organization) and antibiotic biosynthesis/metabolism. Although a few terms reference plant secondary metabolism, the strongest recurring theme centers on bacterial cell wall assembly and related antibiotic pathways.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0071412","count":4},{"id":"GO:0052697","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0070395","count":4}]},{"hash":"1960124271966786797","title":"Neuronal development and synaptic morphogenesis","description":"The top terms cluster around neuronal signaling and structural organization: Rho-mediated signal transduction, dendritic spine morphogenesis, motor neuron axon guidance, protein localization to synapse, receptor clustering, and cell-matrix adhesion. These together point to processes governing neuronal connectivity, synapse formation, and axon guidance. Some outliers (heart development, DNA repair) exist but do not dominate the cluster\u2019s overall theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007266","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0008285","count":2}]},{"hash":"8610909609762925","title":"Unknown","description":"The top GO terms cover protein folding (peptidyl-prolyl isomerization), ubiquitin-dependent degradation and autophagy, plus cell cycle and neural differentiation/synapse organization. There isn\u2019t a clear, single biological theme linking all terms, suggesting the cluster mixes protein homeostasis with neural development signals. Therefore, a concise, representative label cannot be confidently assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000413","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0050808","count":2},{"id":"GO:0030182","count":2}]},{"hash":"209188117714563956","title":"Auditory system development and synapse formation","description":"Multiple GO terms point to brain/inner ear development, hearing (sensory perception of sound), and synapse assembly (presynaptic active zone) with GABAergic transmission, suggesting a cluster of proteins involved in auditory nervous system development and synaptic connectivity.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0071681","count":2},{"id":"GO:0051932","count":2}]},{"hash":"1837401281223497947","title":"Pentose phosphate pathway metabolism","description":"The cluster is strongly linked to pentose phosphate shunt (oxidative and non-oxidative branches), pentose catabolic processes, and carbon utilization, indicating a cohesive focus on pentose and carbohydrate metabolism; a few lipid-related terms appear peripheral. ","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009052","count":1},{"id":"GO:0044262","count":1},{"id":"GO:0006098","count":1},{"id":"GO:0019323","count":1},{"id":"GO:0015976","count":1}]},{"hash":"1033866507164616628","title":"Biosynthesis and cell wall metabolism","description":"The top GO terms are dominated by various biosynthetic processes (antibiotic biosynthesis/metabolic process, lipoteichoic acid biosynthesis, lignin and quercetin glucoside biosynthesis, carbohydrate metabolism) and a related cell wall organization/process term. This suggests the proteins group around biosynthetic pathways and cell wall-related functions, spanning organisms, with a few less cohesive terms (genistein response, obsolete xenobiotic processes) that don\u2019t overturn the central theme. Therefore, a label focusing on biosynthesis and cell wall metabolism fits best.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0071412","count":2},{"id":"GO:0052697","count":2},{"id":"GO:0070395","count":2}]},{"hash":"1549049566057956977","title":"Cardiac development and conduction","description":"The strongest signals are heart-related, including electrical coupling for cardiac conduction and heart trabecula formation, with related terms pointing to cardiac development. While there are also generic processes (protein folding, sumoylation) and some unrelated/obsolete terms, the cardiac terms dominate, suggesting a cardiac development/conduction theme for the cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0086064","count":3},{"id":"GO:0033197","count":3},{"id":"GO:0022417","count":3},{"id":"GO:0016925","count":3},{"id":"GO:1990000","count":3}]},{"hash":"805169569508093908","title":"Embryonic organogenesis across multiple organs","description":"The top GO terms point to development across a range of tissues (pituitary, telencephalon, spinal cord, pancreas, heart, ureteric bud) and regulation of cell fate, indicating a broad theme of embryonic organ development rather than a single specific pathway. This supports labeling the cluster as multi-organ developmental regulators. ","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021983","count":5},{"id":"GO:0022037","count":4},{"id":"GO:1902870","count":4},{"id":"GO:0042663","count":4},{"id":"GO:0002087","count":4}]},{"hash":"1630794454102127537","title":"Cytochrome c mediated mitochondrial apoptosis and ROS","description":"These proteins point to mitochondrial control of apoptosis, with cytochrome c\u2013related activation and links to electron transport chain steps (cytochrome c to oxygen; ubiquinol to cytochrome c) and hydrogen peroxide metabolism, indicating a cohesive theme of mitochondrial apoptotic signaling and redox/ROS regulation. Some terms (photosynthesis, CO response) are broader or context-dependent, but the core set supports a mitochondria-centered apoptotic/oxidative balance function.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0034465","count":3},{"id":"GO:0006470","count":3},{"id":"GO:0006123","count":3},{"id":"GO:0006122","count":3}]},{"hash":"633211210167840337","title":"Keratinocyte differentiation and epidermal proliferation","description":"The top terms cluster around skin biology, notably keratinocyte differentiation and regulation of epidermal cell division, plus related cell-cycle control and keratinocyte proliferation signals (with supporting glucocorticoid signaling). Some neural terms appear, but the dominant theme is epidermal/keratinocyte development and proliferation, justifying this label.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010482","count":5},{"id":"GO:0000079","count":5},{"id":"GO:0042921","count":5},{"id":"GO:0090168","count":5},{"id":"GO:0001764","count":5}]},{"hash":"528651869292315430","title":"Oocyte maturation and follicle signaling","description":"This cluster highlights reproductive biology terms: ovulation from ovarian follicle and positive regulation of oocyte maturation, plus involvement of hepatocyte growth factor receptor signaling, all pointing to follicle development and oocyte maturation. The other terms reflect broader cellular stress and chromatin regulation that can accompany rapidly changing cellular states but are less specific to reproduction; overall, the strongest signal is for oocyte maturation and follicle signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090400","count":1},{"id":"GO:1902237","count":1},{"id":"GO:0001542","count":1},{"id":"GO:1900113","count":1},{"id":"GO:0048012","count":1}]},{"hash":"776865255473039564","title":"Regulation of diverse cellular processes","description":"The top GO terms point to various regulatory roles across distinct biological contexts (e.g., regulation of dolichyl phosphate biosynthesis, T cell regulation, mRNA export, autophagosome activity, signaling, and migration). There is no single cohesive function tying all proteins together beyond broad regulation, so a general label for regulatory diversity is most appropriate. Note that one term is obsolete and does not inform function. ","confidence":"Medium","size":5,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010794","count":4},{"id":"GO:1901165","count":4},{"id":"GO:0002669","count":4},{"id":"GO:0010793","count":4},{"id":"GO:0061736","count":4}]},{"hash":"1733141756768041156","title":"Mitotic cycle and chromosome segregation","description":"The top GO terms point strongly to mitosis (mitotic cell cycle, exit from mitosis, mitotic sister chromatid separation) and DNA replication (DNA replication, leading strand elongation), indicating a cluster of proteins involved in cell division and genome duplication. While there are a few other terms related to vesicle transport and organelle movement, the dominant signal is cell-cycle\u2013related machinery.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0035099","count":3},{"id":"GO:0010458","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051306","count":3}]},{"hash":"923910030419952094","title":"Histone modification and chromatin remodeling","description":"The top GO terms are dominated by histone modifications (H3-K27 trimethylation, H3-K4 demethylation, H3-K23 acetylation) and chromatin-related processes, pointing to regulation of chromatin state. Additional terms for spermatid nucleus differentiation and spindle assembly suggest chromatin remodeling during gametogenesis and cell division. A few entries are obsolete or less directly related, but the core signal is clearly chromatin state regulation, supporting this label.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045869","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0090308","count":2},{"id":"GO:0034720","count":2},{"id":"GO:0043972","count":2}]},{"hash":"1244005080823425380","title":"Embryonic and placental development","description":"The top GO terms cluster around embryonic patterning, placental and endocrine development, and differentiation of trophoblasts, with related processes like EMT and cartilage morphogenesis, suggesting proteins involved in early development and placental formation; a few RNA-processing terms are ancillary.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":5},{"id":"GO:0060806","count":5},{"id":"GO:0035270","count":5},{"id":"GO:0060707","count":5},{"id":"GO:0003323","count":5}]},{"hash":"1183712881230939095","title":"Cell Cycle Regulation and Developmental Morphogenesis","description":"This cluster is anchored by strong representation of cell cycle control terms (G1/S transition, mitotic cell cycle, meiotic transitions) and mitotic spindle processes, suggesting involvement in cell division regulation. The presence of morphogenesis-related terms (trophectodermal morphogenesis, liver morphogenesis, egg chamber growth) indicates a broader developmental context where cell proliferation coordinates tissue formation. Taken together, the proteins likely participate in coordinating cell division with developmental morphogenesis across different tissues.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000082","count":3},{"id":"GO:0001831","count":3},{"id":"GO:0072576","count":3},{"id":"GO:0007295","count":3},{"id":"GO:0035019","count":3}]},{"hash":"976953093830448664","title":"Ubiquitin-mediated regulation of immune signaling","description":"This cluster centers on ubiquitination and proteasomal degradation (protein ubiquitination; ubiquitin-dependent protein catabolic process) coupled with immune pathway modulation (adaptive immune response; T cell receptor signaling regulation; JNK cascade regulation). While differentiation terms appear, the dominant theme ties protein turnover to immune signaling control.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034260","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0006511","count":2},{"id":"GO:0048863","count":2},{"id":"GO:0032436","count":2}]},{"hash":"236235314343425156","title":"Neural Development and Signaling","description":"Most terms point to neural biology, including cellular response to thyroid hormone stimulus (neural development influences), short-term memory, neuropeptide catabolic processes, and positive regulation of neural precursor cell proliferation, suggesting a cluster centered on neural development and signaling. Obsolete or less direct terms (collagen/ossification, keratinocyte proliferation) are present but do not dominate the functional theme. Confidence: Medium","confidence":"","size":5,"edges":5,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":2},{"id":"GO:0001913","count":2},{"id":"GO:0001957","count":2},{"id":"GO:0035593","count":2},{"id":"GO:0007614","count":2}]},{"hash":"1803537697987829780","title":"Nucleotide Salvage and Biosynthesis","description":"The top GO terms cluster around nucleotide metabolism (AMP salvage, nucleoside monophosphate phosphorylation, ADP/CDP biosynthesis, purine ribonucleotide interconversion, ITP metabolism), indicating a shared function in nucleotide salvage and synthesis; a few tissue development terms (brain and liver development) appear but are less central to the cluster's core activity.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0044209","count":5},{"id":"GO:0046940","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0046041","count":4},{"id":"GO:0046939","count":4}]},{"hash":"1257282966867377271","title":"TGF-beta signaling in embryonic morphogenesis","description":"The terms cluster around developmental signaling and morphogenesis, dominated by TGF-beta receptor signaling and SMAD complex assembly, plus gastrulation and morphogenesis-related processes such as commissural neuron axon guidance and organ development. This points to a coherent theme of developmental signaling guiding tissue patterning and morphogenesis across neural and organ contexts, with ancillary terms tied to specific developmental events.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007179","count":3},{"id":"GO:0001702","count":3},{"id":"GO:0007183","count":3},{"id":"GO:0070723","count":2},{"id":"GO:0034616","count":2}]},{"hash":"2297130341651875427","title":"Embryonic Development and Neurogenesis","description":"This set emphasizes developmental processes across nervous system formation (peripheral nervous system neuron development, telencephalon/metencephalon development) and broader embryogenesis (primitive streak formation) as well as organogenesis (pancreas and heart development). The lack of interactions suggests these proteins participate in diversified developmental programs rather than a single pathway, so a label that reflects broad embryonic/neurodevelopment is appropriate.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048935","count":4},{"id":"GO:0090009","count":4},{"id":"GO:0022037","count":2},{"id":"GO:1902870","count":2}]},{"hash":"1995742954235988156","title":"Embryonic development and organ morphogenesis","description":"This cluster's terms center on embryogenesis, left-right patterning, mesoderm and placenta-related development, and various morphogenetic processes (hair follicle, roof of the mouth, endocardial EMT), indicating a shared theme of embryonic development and tissue morphogenesis across multiple organs.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0007498","count":2},{"id":"GO:0060021","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0060707","count":2}]},{"hash":"101781583943098854","title":"Mesodermal Development and Hematopoietic Regulation","description":"The terms cluster around development of mesoderm-derived tissues and hematopoietic/immune lineages (megakaryocyte development, blood vessel morphogenesis, innate immune response, cell fate determination, and mesoderm-related regulation), with transcriptional regulation as a supporting mechanism. This pattern suggests a coherent theme of developmental and hematopoietic/immune differentiation rather than unrelated processes.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0035019","count":3},{"id":"GO:1902262","count":3},{"id":"GO:0045087","count":3},{"id":"GO:2000382","count":2}]},{"hash":"2064918014510370774","title":"Adrenergic and Dopaminergic GPCR Signaling","description":"The top GO terms point strongly to adrenergic receptor signaling (MAPK-activating and PLC-activating pathways, and adenylate cyclase interactions) along with dopaminergic synaptic transmission and related brain functions like blood pressure regulation and synaptic modulation. Together these suggest a cluster centered on GPCR-mediated neurotransmitter signaling in the brain, particularly adrenergic and dopaminergic pathways, with downstream effects on synaptic plasticity and vascular tone. Some immune-related terms appear but do not redefine the main theme. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":5},{"id":"GO:0001963","count":5},{"id":"GO:1900453","count":5},{"id":"GO:0001994","count":5},{"id":"GO:0071883","count":5}]},{"hash":"302368749042773499","title":"Tooth development and mineralization","description":"This cluster is dominated by GO terms related to the formation and mineralization of dental tissues (dentinogenesis, odontoblast differentiation, enamel mineralization, tooth eruption) and associated bone formation processes (osteoblast differentiation, bone mineralization), with regulatory signaling (FGFR pathway) that supports these developmental processes. A retinal/homeostasis term and a pain regulation term appear ancillary but do not negate the central theme of dental and skeletal mineralization. Overall, the terms point to a coherent function in dental tissue formation and mineralization, sometimes linked with bone formation.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051930","count":2},{"id":"GO:0001895","count":2},{"id":"GO:0044691","count":1},{"id":"GO:0097187","count":1},{"id":"GO:1903955","count":1}]},{"hash":"165342380492635879","title":"Plant Cell Wall Biosynthesis and ER Glycosylation","description":"This cluster shows enrichment for plant-type cell wall biogenesis and polysaccharide biosynthesis (glucuronoxylan, homogalacturonan, mucilage), along with galactose metabolism and protein O-linked glycosylation via mannose and via N-acetyl-galactosamine, plus ER targeting. The presence of ER-related processes together with cell wall polysaccharide biosynthesis suggests these proteins function in the secretory pathway to assemble and modify plant cell wall components, despite the small cluster size. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006465","count":1},{"id":"GO:0045047","count":1},{"id":"GO:0010192","count":1},{"id":"GO:0006012","count":1},{"id":"GO:0035269","count":1}]},{"hash":"586174920318484342","title":"Embryogenesis and organ differentiation","description":"The Top Terms are dominated by developmental processes and tissue specification: left/right pattern formation; placental development and trophoblast differentiation; endocrine system and pancreatic cell development; EMT events during endocardial cushion formation; cartilage morphogenesis. This cluster appears to group proteins involved in embryogenesis and subsequent organogenesis rather than a single tissue or pathway, so a concise label that captures broadly developmental differentiation is appropriate.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003323","count":3}]},{"hash":"934854532355712131","title":"RNA Pol II Transcriptional Repression","description":"The top GO terms are centered on negative regulation of transcription by RNA polymerase II and DNA-templated transcription, which suggests the cluster is largely about transcriptional repression. The remaining terms (pattern formation, nephron differentiation, stem cell maintenance, signaling) are more diverse and less directly tied to transcription, implying broader regulatory roles or annotation breadth rather than a single cohesive function. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:1903026","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0060972","count":3},{"id":"GO:0035019","count":3}]},{"hash":"1154092709727992761","title":"Neuronal ubiquitin-mediated turnover and synapse formation","description":"The terms cluster around ubiquitin-dependent protein catabolic processes and polyubiquitination, indicating a core function in ubiquitin-proteasome\u2013mediated proteostasis. Neural-development-related terms (synapse assembly in innervation, neural tube closure initiation) suggest this proteostasis activity is relevant to neural development and synaptogenesis, while oxidative stress\u2013 and methylmercury\u2013response terms reflect neuron-specific stress signaling converging on ubiquitin pathways.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0032088","count":3},{"id":"GO:1903378","count":3},{"id":"GO:0071406","count":3},{"id":"GO:0060386","count":3}]},{"hash":"1206405167220051841","title":"Glycolysis and carbohydrate metabolism","description":"The cluster shows strong signals for glycolytic process, fructose metabolism, carbohydrate phosphorylation, and related sugar-processing steps (GO:0006096, GO:0006000, GO:0046835, GO:0016311), with a link to serine biosynthesis (GO:0006564) via sugar carbon flux. While a couple of terms touch broader or peripheral processes (intestinal development, respiratory exchange, DNA damage signaling), the dominant theme ties to central carbon metabolism and glycolysis. ","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":1},{"id":"GO:0046835","count":1},{"id":"GO:0006000","count":1},{"id":"GO:0045730","count":1},{"id":"GO:0006096","count":1}]},{"hash":"163488036148873804","title":"Vascular ECM remodeling and growth factor signaling","description":"This cluster is dominated by GO terms linking collagen fibril organization, negative regulation of VEGF and HGF receptor signaling, and platelet aggregation\u2014points to extracellular matrix remodeling and vascular growth-factor\u2013mediated signaling control. While a few terms are less related (bacterial agglutination, MHC II antigen processing, pyramidal neuron differentiation), the shared thread appears to be ECM-associated processes that modulate angiogenesis and platelet function, suggesting a vascular/ECM regulatory theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0070528","count":2},{"id":"GO:0090331","count":2},{"id":"GO:1902203","count":2},{"id":"GO:1902548","count":2}]},{"hash":"1197780091510962377","title":"Neural crest development and PNS myelination","description":"The top GO terms point to neural crest cell development and peripheral nervous system myelination, indicating a neural-development module. Other terms relate to development and transcription regulation, but the core signal is neural crest\u2013derived development and Schwann-cell\u2013mediated myelination in the PNS.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0014032","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0045944","count":2}]},{"hash":"1147506317453272994","title":"RNA Pol II Transcription Regulation","description":"The strongest non-obsolete terms center on RNA polymerase II\u2013mediated transcription, including negative regulation of transcription by RNA Pol II and DNA-templated transcription, which suggests the cluster is mainly about transcriptional control. A few other terms (metabolic catabolic processes) are present but less representative, so the label reflects the primary theme with moderate confidence.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0010729","count":4},{"id":"GO:0046022","count":4},{"id":"GO:0007576","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0070895","count":4}]},{"hash":"1566830272385087677","title":"Neural synaptic transmission and plasticity","description":"The top terms cluster around neuronal communication and synaptic modulation\u2014learning, receptor internalization, synapse organization, regulation of excitatory postsynaptic potentials, and synaptic vesicle exocytosis\u2014suggesting a function in synaptic transmission and plasticity. A few terms related to plant hormones or alkaloids appear as outliers and do not fit the neural theme, likely noise. ","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":2},{"id":"GO:0031623","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0002087","count":2},{"id":"GO:2000302","count":2}]},{"hash":"695666127617249315","title":"Brain catecholamine signaling and dopaminergic transmission","description":"The top GO terms center on brain-specific signaling and neurotransmission, including brain renin-angiotensin system, dopaminergic synaptic transmission, adrenergic receptor signaling (MAPK-activating, phospholipase C-activating, and calcium signaling aspects), and norepinephrine-epinephrine\u2013related vasoconstriction. This points to a cohesive theme of catecholaminergic and GPCR-driven signaling in neural contexts. A few terms (immune differentiation and neutrophil chemotaxis) are less related and may reflect broader annotations, but they are outnumbered by neural signaling terms.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002035","count":4},{"id":"GO:0001963","count":4},{"id":"GO:1900453","count":4},{"id":"GO:0001994","count":4},{"id":"GO:0071883","count":4}]},{"hash":"2047283032831019374","title":"Olfactory system development","description":"The top GO terms cluster around olfactory development (olfactory placode morphogenesis, olfactory nerve formation) and neural signaling (nervous system development, GPCR signaling related to olfactory receptors). Other terms reflect general cellular processes that are less specific to this cluster, but the olfactory-related terms provide a coherent theme of olfactory neuron development and signaling. ","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006869","count":1},{"id":"GO:0043523","count":1},{"id":"GO:0070207","count":1},{"id":"GO:0038003","count":1},{"id":"GO:0007399","count":1}]},{"hash":"107876401812886276","title":"Unknown","description":"The GO terms span plant metabolism (glucosinolate catabolic process) and hormone signaling (brassinosteroid pathway), developmental processes (flower development, distal tubule morphogenesis, sarcomere organization), immune signaling (B cell receptor signaling), circadian rhythm regulation, and mitotic/ chromosome-related localization, indicating no single cohesive function linking the proteins. The terms are too diverse to assign a meaningful, specific common function to this cluster.","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019762","count":2},{"id":"GO:0072156","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0035853","count":2},{"id":"GO:0050853","count":2}]},{"hash":"1434395984152663652","title":"Collagen remodeling and bone formation","description":"The GO terms point strongly to extracellular matrix processes, especially collagen fibril organization, collagen biosynthesis and catabolism, and two pathways of bone formation (endochondral and intramembranous ossification). There are also signals related to mechanical stimulus responses and growth factor signaling, which fit ECM remodeling and mechanotransduction in bone development. This supports a cohesive label around collagen-driven ECM remodeling and ossification processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0001958","count":2},{"id":"GO:0035987","count":2},{"id":"GO:0001957","count":2},{"id":"GO:0030574","count":2}]},{"hash":"2012261101929540624","title":"Nuclear transport and mitosis","description":"This cluster is tied to nuclear transport processes (tRNA export, import into nucleus, NLS-bearing import) and mitotic choreography (mitotic nuclear membrane disassembly, chromosome attachment to the nuclear envelope). The presence of protein oligomerization terms also aligns with assembly steps common in nuclear transport complexes, supporting a cohesive theme around nuclear transport during mitosis.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007077","count":3},{"id":"GO:0006409","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0075733","count":3},{"id":"GO:0010827","count":3}]},{"hash":"155847144242294924","title":"Lipid metabolism and adipose development","description":"The terms emphasize lipid metabolism (fatty acid beta-oxidation, acetyl-CoA/propionyl-CoA biosynthesis), cholesterol transport, and adipose tissue development, with a hormonal response signal; one term about poly-hydroxybutyrate biosynthesis may be an annotation anomaly, but the main signal is lipid-related functions.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":4},{"id":"GO:0032385","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0014070","count":4},{"id":"GO:0046356","count":4}]},{"hash":"30738687901819822","title":"Neurodevelopment and mitosis","description":"This cluster combines strong signals for brain development and neural tube closure with mitotic processes such as the cell cycle and spindle assembly, suggesting a theme where neural development is coordinated with cell division. Additional terms point to cytoskeletal dynamics and trafficking, but the dominant pattern centers on neurodevelopment linked to mitosis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0007275","count":2}]},{"hash":"581704120927198530","title":"Telomere maintenance and DNA repair","description":"The top GO terms point strongly to telomere biology (positive regulation of telomere maintenance via telomerase, protein localization to chromosome telomeric region) and various DNA repair processes (single-strand break repair, mitochondrial DNA repair, and related DNA damage responses). While a couple of terms touch on development or metabolism, the dominant theme across the cluster is genome maintenance and telomere-associated repair mechanisms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":2},{"id":"GO:0008585","count":2},{"id":"GO:0071696","count":2},{"id":"GO:0071360","count":2},{"id":"GO:1903518","count":2}]},{"hash":"1740308695922048916","title":"ECM Remodeling and Morphogenesis","description":"The proteins cluster around extracellular matrix (ECM) organization and remodeling, with terms like collagen fibril organization and elastic fiber assembly, plus integrin signaling and plasminogen activation regulation, indicating ECM-cell interactions and remodeling. Developmental and morphogenesis terms (ureteric bud branching, ovarian follicle ovulation, BMP response) suggest tissue remodeling during development. Together, these point to ECM remodeling as the core theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043569","count":2},{"id":"GO:0001542","count":1},{"id":"GO:0001658","count":1},{"id":"GO:0001558","count":1},{"id":"GO:0007229","count":1}]},{"hash":"1023436127333718906","title":"Podocyte Development and ECM/Adhesion Signaling","description":"The strongest signal is metanephric podocyte development, complemented by extracellular matrix disassembly and regulation of cadherin-mediated cell adhesion, together pointing to podocyte formation and ECM remodeling. PKC signaling and lipid localization provide supporting context for cytoskeletal and membrane dynamics in podocytes; some terms are distant or outdated, but the core theme remains podocyte development with ECM/adhesion processes.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0010918","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0010876","count":3}]},{"hash":"2108390789243687533","title":"Mitotic spindle dynamics","description":"The top GO terms are dominated by mitotic spindle/microtubule functions: plus-end specific depolymerization, plus-end directed sliding, spindle elongation, and kinetochore attachment. These collectively reflect core roles in spindle assembly and chromosome segregation during mitosis, which best explains the cluster's protein set. While a few terms touch on neuronal signaling or endosome transport, the shared theme across the most enriched terms is microtubule dynamics during cell division.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070462","count":2},{"id":"GO:0007274","count":2},{"id":"GO:0021685","count":2},{"id":"GO:0045190","count":2},{"id":"GO:0008333","count":2}]},{"hash":"1632346155128189439","title":"Keratinocyte differentiation and epidermal growth control","description":"This cluster prominently features GO terms related to keratinocyte differentiation and regulation of epidermal cell division (e.g., keratinocyte differentiation, regulation of epidermal cell division, negative regulation of keratinocyte proliferation), indicating a shared role in epidermal development and skin homeostasis. The inclusion of nuclear receptor\u2013mediated glucocorticoid signaling supports hormonal regulation of skin physiology, while GO terms related to cyclin-dependent kinase activity regulation and protein heterooligomerization point to cell-cycle control and protein complex formation within epidermal cells. Less-specific terms such as Golgi reassembly and neuron migration exist but do not override the epidermis-focused theme; overall, these proteins appear to participate in keratinocyte maturation and epidermal growth control.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":2},{"id":"GO:0010482","count":2},{"id":"GO:0000079","count":2},{"id":"GO:0042921","count":2},{"id":"GO:0090168","count":2}]},{"hash":"1930753185633128984","title":"DNA Replication, Repair, and Recombination","description":"Top GO terms point to core processes of DNA replication, DNA repair, and recombination, including replication-associated repair, meiosis/recombination, and damage-response pathways (e.g., SOS response and cellular responses to cisplatin and camptothecin). The presence of replication-born DSB repair via sister chromatid exchange and recombination-dependent replication fork processing supports a cohesive genome maintenance module. ","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0007131","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0072719","count":2},{"id":"GO:1990414","count":2}]},{"hash":"1880490269162099492","title":"DNA replication and chromatin silencing","description":"Based on GO terms dominated by chromatin regulation (heterochromatin formation, telomere silencing) and core DNA replication and cell-cycle processes (DNA replication, pre-replicative complex assembly, chromosome condensation, cell division), this cluster appears to group proteins involved in chromatin state maintenance during replication and early cell-cycle events.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030466","count":2},{"id":"GO:0007076","count":1},{"id":"GO:0046331","count":1},{"id":"GO:0006270","count":1},{"id":"GO:0031938","count":1}]},{"hash":"1934163838281219235","title":"Development and Chromatin Regulation","description":"This cluster is dominated by GO terms for development (multicellular organism development, forebrain development) along with cell cycle processes (mitotic cell cycle, regulation of cell cycle checkpoint) and chromatin organization, suggesting a group of proteins involved in developmental programs that are coordinated through chromatin remodeling and cell-cycle control. Additional terms like TGF-beta response and protein homooligomerization reinforce a signaling-regulated developmental module, while a few terms (e.g., taste perception) appear tangential, likely reflecting broad tissue expression. Overall, a coherent interpretation is developmentally oriented with chromatin-based gene regulation and cell-cycle coordination.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0060528","count":3},{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2}]},{"hash":"991074732247299496","title":"Unknown","description":"The top GO terms are heterogeneous, including neuronal signaling and dendrite development (short-term synaptic potentiation, presynapse to nucleus signaling, dendrite extension) but also plant stomatal closure, DNA repair regulation, lysosome exocytosis, and insulin secretion. There isn\u2019t a single coherent function tying all terms together, so a specific label isn\u2019t justifiable. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021814","count":2},{"id":"GO:0090332","count":2},{"id":"GO:0032425","count":2},{"id":"GO:1905171","count":2},{"id":"GO:1990926","count":2}]},{"hash":"48096805278206187","title":"Mitochondrial Membrane Transport and Dynamics","description":"The cluster\u2019s GO terms emphasize transmembrane transport across membranes (NAD, glycine, ornithine, deoxynucleotides, thiamine pyrophosphate) and mitochondrial membrane processes (fission, permeability), pointing to a core role in mitochondrial transport and membrane remodeling; notes of amino acid starvation response and liver regeneration may reflect broader metabolic stress contexts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035352","count":1},{"id":"GO:0034198","count":1},{"id":"GO:0000066","count":1},{"id":"GO:0097421","count":1},{"id":"GO:0036233","count":1}]},{"hash":"887344075929760997","title":"Chromatin Regulation and DNA Transcription","description":"The cluster centers on nuclear gene expression control, with terms for DNA-templated transcription, chromatin organization, and histone H3 acetylation, plus cell cycle and mitotic regulation, suggesting a cohesive theme of transcriptional regulation and chromatin remodeling. TGF-beta\u2013related response and osteoblast differentiation terms further support a developmental regulatory context, while a few outliers (e.g., taste perception) are likely noise.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0051260","count":2}]},{"hash":"171644509937894294","title":"RTK and BCR signaling network","description":"This cluster centers on receptor tyrosine kinase\u2013related signaling pathways, including ERBB2 signaling, PI3K/Ras/Rho downstream regulation, and IP3/phospholipid signaling, with GO terms also highlighting B cell receptor signaling and follicular B cell differentiation. Together, these terms point to RTK-driven signal transduction with immune cell (B cell) regulation as the shared theme, despite some broader signaling annotations present. Confidence: Medium","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0038028","count":4},{"id":"GO:0050764","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0046580","count":4},{"id":"GO:0032959","count":4}]},{"hash":"1419804174215080647","title":"Ciliary assembly and transport","description":"This cluster is driven by cilia-related terms such as cilium movement, intraciliary retrograde transport, and inner dynein arm assembly, pointing to a shared role in ciliary structure and function. Some non-ciliary terms appear in the list (ubiquitin-dependent processes, chlorophyll biosynthesis, stamen formation), likely representing annotation noise or multi-function proteins; however, the strongest signal is ciliary. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006511","count":1},{"id":"GO:0015995","count":1},{"id":"GO:0043248","count":1},{"id":"GO:0048455","count":1},{"id":"GO:0021670","count":1}]},{"hash":"1233404621501707065","title":"Chromatin Regulation and Cell Cycle Control","description":"The top GO terms are dominated by nuclear processes: chromatin organization, histone H3 acetylation, mitotic cell cycle, and regulation of cell cycle checkpoint, pointing to epigenetic regulation linked to cell division. Additional terms about TGF-beta signaling and osteoblast differentiation fit into differentiation contexts downstream of chromatin regulation. Some terms (taste perception, defense response) seem unrelated and may be annotation noise. Overall, the strongest coherent theme is chromatin regulation coupled with cell cycle control.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:1901976","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0031497","count":2}]},{"hash":"1100387588871604228","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0071031","count":2},{"id":"GO:1902219","count":2},{"id":"GO:0070934","count":2},{"id":"GO:0031564","count":2}]},{"hash":"1958148162830683846","title":"Vesicular and Membrane Transporters","description":"Proteins in this cluster share a prominent theme of membrane transport activities, including neurotransmitter loading into synaptic vesicles and various transmembrane transport processes (nitrite, nitrate, sodium, phosphate, sugars, xenobiotics). The convergence on transporter activity suggests these proteins function broadly as membrane transporters, with a possible emphasis on vesicular transport in neurons. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098700","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0015751","count":4},{"id":"GO:0015739","count":4},{"id":"GO:0035435","count":4}]},{"hash":"2109629757265115358","title":"Ubiquitin-Dependent Immune Signaling","description":"This cluster centers on ubiquitination and ubiquitin-dependent protein degradation (ERAD, autoubiquitination) and ties to immune pathways (innate immunity, TNF signaling, NF-kB, JNK) plus T cell proliferation. The common thread is how ubiquitin-mediated turnover modulates inflammatory signaling and immune responses, consistent with a ubiquitin-dependent immune signaling function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0033280","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0046328","count":2}]},{"hash":"610042352982552263","title":"Developmental morphogenesis and cell polarity","description":"The top GO terms cluster around developmental processes (nervous system development, spermatid development, dendrite development) and epithelial morphogenesis/polarity, suggesting a developmental/morphogenetic theme. A few terms (mitotic cycle, endosome transport) are broader or ancillary but do not override the central developmental signal.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0097327","count":1},{"id":"GO:0048227","count":1}]},{"hash":"1927998613926250727","title":"Unknown","description":"The GO terms associated with this cluster are scattered across muscle contraction, kidney filtration, pigment transport, mitochondrial inheritance, and organ identity, with each term represented by a single protein. There isn't a unifying function or pathway that links these proteins, making it hard to assign a cohesive label. Therefore Unknown.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045769","count":1},{"id":"GO:0003009","count":1},{"id":"GO:1903923","count":1},{"id":"GO:0003094","count":1},{"id":"GO:0009826","count":1}]},{"hash":"858819505192901744","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008615","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006096","count":1},{"id":"GO:0042823","count":1},{"id":"GO:0035606","count":1}]},{"hash":"2237137543438809521","title":"Unknown","description":"The GO terms span light sensing, vascular remodeling, neuronal development and transport, transcription regulation in metabolic contexts, phosphorylation, epithelial morphogenesis, and cardiac depolarization. With only 4 proteins and scattered terms (max degree 1, no triangles), there is no coherent shared function to name; the cluster appears heterogeneous or possibly artifactual. Therefore cannot assign a meaningful label.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010201","count":1},{"id":"GO:0097497","count":1},{"id":"GO:0061415","count":1},{"id":"GO:0019896","count":1},{"id":"GO:0061414","count":1}]},{"hash":"1563269741365314717","title":"Auditory hair cell development and ion transport","description":"This cluster centers on terms related to inner ear sensory biology, including response to auditory stimulus and inner ear receptor cell development, along with potassium and calcium ion transport and homeostasis, as well as microvillus assembly regulation. Together these point to proteins involved in cochlear hair cell function and the ion-channel\u2013driven signaling essential for hearing.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010996","count":3},{"id":"GO:0003011","count":2},{"id":"GO:0010107","count":2},{"id":"GO:0032534","count":2},{"id":"GO:0030007","count":2}]},{"hash":"628998876277343069","title":"Nucleocytoplasmic export of RNA and ribosomal subunits","description":"The top GO terms cluster around export/import processes across the nuclear envelope: mRNA export, ribosomal small and large subunit export, tRNA re-export, and import of NLS-bearing proteins, with a few regulatory terms overlapping transcription and centrosome control. This points to a shared function in nucleocytoplasmic transport of RNA and ribosome components, despite some ancillary regulatory terms. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0034501","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0000056","count":2},{"id":"GO:0042493","count":2}]},{"hash":"2009175558237245102","title":"Membrane Transport Proteins","description":"The top GO terms are dominated by transmembrane transport of various substrates (chloride, fructose, bicarbonate, sulfate, oxalate, aspartate) and by regulation of membrane potential; additional terms reflect transporter roles in processes like gastric acid secretion and sperm capacitation, which also depend on ion and solute movement across membranes. Taken together, they suggest a cluster of proteins that function primarily as membrane transporters with diverse substrates.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902476","count":2},{"id":"GO:0015755","count":1},{"id":"GO:0042391","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0089712","count":1}]},{"hash":"1947482583152639123","title":"Neural development and synaptic plasticity","description":"Dominant GO terms cluster around brain development and long-term synaptic potentiation, pointing to neural development and synaptic plasticity as the core function; sensory taste also supports a neural/sensory signaling theme, with a few general cellular process terms present but not overriding the neural signal.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007584","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0060770","count":2},{"id":"GO:0060291","count":2},{"id":"GO:0030433","count":1}]},{"hash":"37300461823104541","title":"Apoptosis and endomembrane trafficking","description":"Top GO terms show a mix of apoptotic signaling and vesicle/endosomal transport processes, suggesting a module that links cell death pathways with intracellular trafficking and vacuolar targeting. This combination provides a plausible, cohesive theme for a small cluster, though the exact functional connection is modestly supported by the limited term counts.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0098711","count":1},{"id":"GO:0034316","count":1},{"id":"GO:0006623","count":1},{"id":"GO:1901030","count":1}]},{"hash":"1494313415578721578","title":"Nervous system and cardiac development","description":"The top GO terms are dominated by nervous system development and cardiac neural crest cell development involved in heart development, with angiogenesis also prominent, pointing to a developmental program for neural and cardiovascular tissues. Additional terms reflect secretory processes (calcium-dependent exocytosis) and immune/apoptotic signaling, but the core signal centers on neurodevelopment and heart-associated vascular development.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045956","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0033129","count":3},{"id":"GO:0090606","count":3},{"id":"GO:0000186","count":3}]},{"hash":"2224325648849527303","title":"Developmental morphogenesis and cell migration","description":"The top GO terms cluster around tissue development, ECM remodeling and cell movement: collagen fibril organization, angiogenesis, forebrain cell migration, vestibular receptor cell morphogenesis, slit diaphragm assembly, and synapse organization. This suggests a general theme of how cells and extracellular matrix coordinate to shape tissues during development, rather than a single canonical pathway. Some terms are obsolete, but do not negate the overall developmental/morphogenetic trend.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0060116","count":3},{"id":"GO:1904237","count":3},{"id":"GO:0055072","count":3},{"id":"GO:0050808","count":3}]},{"hash":"172605751460692036","title":"Developmental Morphogenesis and ECM Organization","description":"Several terms point to extracellular matrix remodeling (collagen fibril organization) and development across tissues (forebrain cell migration, vestibular receptor morphogenesis, slit diaphragm assembly, angiogenesis, salivary gland boundary specification, synapse organization), suggesting a cohesive theme of morphogenesis guided by ECM interactions and cell migration.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0060116","count":2},{"id":"GO:1904237","count":2},{"id":"GO:0055072","count":2},{"id":"GO:0050808","count":2}]},{"hash":"1901386122501654376","title":"Tissue Morphogenesis and ECM Remodeling","description":"The GO terms point to tissue development and the organization of extracellular matrix and cell\u2013cell interfaces\u2014collagen fibril organization, slit diaphragm assembly, synapse organization, vestibular receptor morphogenesis, and angiogenesis\u2014suggesting a shared role in shaping and remodeling tissues. Some immune signaling and ER stress terms appear, but they are less central to the cluster\u2019s main theme. ","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060116","count":4},{"id":"GO:0030199","count":4},{"id":"GO:1904237","count":4},{"id":"GO:0055072","count":4},{"id":"GO:0050808","count":4}]},{"hash":"1111695772249344164","title":"Cell Adhesion and Junctions","description":"The top GO terms are dominated by adhesion and junction-related processes (homophilic cell-cell adhesion, intermicrovillar adhesion, endothelial barrier establishment), indicating a shared theme around cell\u2013cell contacts and communication across tissues. Some terms are more tissue-specific or auxiliary, but the adhesion-centric terms are the strongest common thread.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902910","count":2},{"id":"GO:0032912","count":2},{"id":"GO:0086073","count":2},{"id":"GO:1903142","count":2},{"id":"GO:0007156","count":2}]},{"hash":"2294595436237618197","title":"Cardiac electrophysiology and conduction","description":"This cluster is dominated by GO terms related to regulation of cardiac action potentials and membrane depolarization, including ventricular and atrial regulation and Purkinje signaling (e.g., GO:0098911, GO:0060371, GO:0086029), often with supporting ion transport (potassium export) terms. While there are some unrelated terms (bone ossification, aldosterone biosynthesis), the strongest and most frequent terms point to cardiac electrical activity and conduction as the core theme. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098911","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0097497","count":2},{"id":"GO:0071435","count":2},{"id":"GO:0051260","count":2}]},{"hash":"2162662119779749993","title":"Intracellular transport and organelle maintenance","description":"Relying GO terms show a core focus on intracellular trafficking and vesicle transport (plasma membrane to endosome, Golgi vesicle fusion, intracellular protein transport), plus organelle maintenance like mitochondrion inheritance. There are additional hints from ribosome biogenesis and JNK cascade regulation, suggesting a broader theme of cellular organization, maintenance, and stress signaling. The varied terms imply a general housekeeping cluster rather than a single, tightly defined pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0015971","count":1},{"id":"GO:0015970","count":1},{"id":"GO:0032781","count":1}]},{"hash":"1383714053989070000","title":"Nervous system development and axon guidance","description":"Top terms center on neuronal development, axon extension/guidance, and related signaling pathways (JNK cascade, serine phosphorylation), indicating a neuronal development theme for this cluster. A subset of terms (mitotic cell cycle, ossification, mast cell degranulation, spermatid development) appear as less central annotations, suggesting some functional diversity or annotation overlap within the cluster.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0033138","count":4},{"id":"GO:0045773","count":4},{"id":"GO:0050771","count":4},{"id":"GO:0043931","count":4}]},{"hash":"1878545133771427742","title":"Vesicle trafficking and membrane localization","description":"The GO terms cluster around transport between membranes (Golgi to plasma membrane, endosome transport, vacuolar membrane localization) and related localization processes, suggesting proteins involved in intracellular vesicle trafficking and membrane localization; a few outliers exist, but the dominant theme is membrane trafficking.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0097327","count":3},{"id":"GO:0048227","count":3},{"id":"GO:1903778","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0045859","count":3}]},{"hash":"2275880908671233924","title":"Neuronal development and synaptic signaling","description":"GO terms are dominated by nervous system development, dendrite morphogenesis, hippocampus development, excitatory postsynaptic potential, and calcium-dependent exocytosis, which together point to neuronal growth and synaptic function. A few terms (T cell receptor signaling pathway, mitotic cell cycle) are non-neuronal outliers, but the prevailing theme supports neuronal development and synaptic activity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045773","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0033138","count":4},{"id":"GO:1903351","count":4}]},{"hash":"2082519720262896768","title":"Inflammation and ECM remodeling with angiogenesis","description":"GO terms center on inflammatory regulation, collagen fibril organization, angiogenesis, nitric oxide production, epithelial morphogenesis, and xenobiotic response, suggesting a cluster of proteins involved in tissue remodeling and vascular/inflammatory signaling. Some terms seem peripheral (e.g., mating plug), but the core theme is inflammation-associated remodeling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042628","count":2},{"id":"GO:0045721","count":2},{"id":"GO:2000098","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0097192","count":2}]},{"hash":"67690695916549671","title":"Ubiquitin-Proteasome Regulation and NF-\u03baB Signaling","description":"The cluster centers on the ubiquitin-proteasome system and immune signaling: deubiquitination, SCF-dependent proteasomal degradation, and proteasome core assembly indicate active protein turnover; TNF-mediated and non-canonical NF-\u03baB signaling connect degradation to signaling. Antigen processing for MHC class I further ties to immune presentation. Stress-related terms (cadmium and salt) and regulation of amino acid metabolism may reflect broader proteostasis-adaptive responses. Overall, a coherent theme is proteostasis linked to immune signaling.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":2},{"id":"GO:0046686","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0010499","count":2},{"id":"GO:0006521","count":2}]},{"hash":"1730905818066800291","title":"Cytoskeleton Remodeling and Mechanotransduction","description":"The cluster's top GO terms point to responses to mechanical stimulus, ruffle and stress fiber assembly, and positive regulation of GTPase activity, all hallmarks of actin cytoskeleton remodeling driven by mechanotransduction. While there are also signals related to Wnt signaling and keratinocyte differentiation, the prevailing theme is cytoskeletal dynamics governing cell shape and movement in response to mechanical cues, with modulation of signaling pathways like ERK providing additional regulatory context.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0097178","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0090263","count":3},{"id":"GO:0000186","count":3}]},{"hash":"869359074657516651","title":"Cardiac and retinal GPCR signaling","description":"The top GO terms point to GPCR-related intracellular signaling and GTPase regulation, with clear emphasis on heart development and cardiac muscle contraction, alongside visual system terms such as opsin-mediated signaling and visual perception. This suggests a theme of GPCR-driven signaling pathways active in both cardiac and retinal contexts, including receptor internalization and downstream GTPase activity. While the heart-related terms are prominent, the inclusion of retinal signaling terms supports a shared GPCR signaling motif across tissues.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0022400","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0060048","count":2}]},{"hash":"1797203080324997668","title":"Nephrogenesis and kidney tubule morphogenesis","description":"The top GO terms cluster around kidney development, including mesonephric duct development and metanephric proximal/distal tubule morphogenesis, indicating a coherent theme of nephrogenesis. While there are immune-related terms present, the strongest signal is kidney organogenesis, justifying a name focused on nephrogenesis. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":4},{"id":"GO:0038094","count":4},{"id":"GO:0072287","count":4},{"id":"GO:2000502","count":4},{"id":"GO:0071226","count":4}]},{"hash":"236908760255181356","title":"Unknown","description":"The GO terms cover multiple, unrelated biological areas (development, neural growth, immune activation, metabolism) with no clear shared function among the four proteins, so there isn't a cohesive theme to name a specific cluster.","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060068","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0022008","count":4},{"id":"GO:0048672","count":3},{"id":"GO:0030277","count":3}]},{"hash":"1232387066652100632","title":"ER Localization and Protein Trafficking","description":"The terms cluster around intracellular localization and movement of proteins, especially toward the endoplasmic reticulum and related membranes (ER localization and ER membrane establishment), as well as ER-to-cytosol retrograde transport and endosome-associated localization. The presence of ribosomal large subunit export from the nucleus suggests a broader trafficking/assembly context for macromolecules. A few terms relate to development or immune signaling, which seem less connected to the core trafficking theme. Overall, the strongest signal is ER-associated localization and trafficking.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":1},{"id":"GO:0061101","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0036010","count":1},{"id":"GO:0010936","count":1}]},{"hash":"1531657188201579027","title":"Cardiac GPCR signaling and catecholamine secretion","description":"The terms point to G protein-coupled receptor signaling, including acetylcholine receptor pathways and regulation of catecholamine release, with a note on heart rudiment formation. This combination suggests a functional cluster centered on cardiac GPCR signaling that modulates heart contraction and catecholamine-driven responses, despite some terms that may reflect broader or noise-related processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003315","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0003108","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0002031","count":1}]},{"hash":"515729477782955105","title":"Neural development and synaptic signaling","description":"GO terms show brain and spinal cord development, neuron-specific transport, and GABAergic synaptic transmission, with sensory perception of sound, suggesting a cluster focused on neuronal development and neural signaling. Some terms are historical/obsolete but the core theme remains neural development and synaptic function.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0007018","count":2},{"id":"GO:0043547","count":2}]},{"hash":"892072082447428594","title":"Immune signaling and inflammatory response","description":"The terms cluster around immune cell signaling and inflammatory processes, including integrin- and calcium-mediated signaling, T cell activation, lymphocyte homeostasis, and mast cell degranulation, indicating a cohesive immune response theme.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0010467","count":2},{"id":"GO:0002260","count":2},{"id":"GO:0007265","count":2},{"id":"GO:0006954","count":2}]},{"hash":"2265157911031120558","title":"Neuronal synapse assembly and ubiquitin regulation","description":"The top terms cluster around neuronal connectivity (synapse assembly in innervation) and ubiquitin-mediated processes (polyubiquitination and ubiquitin-dependent protein catabolic process), indicating a module tied to neuron formation and protein turnover. Some less related terms (circadian regulation, DNA damage checkpoints) may reflect broader cellular roles, but the dominant pattern supports a link between synapse assembly and ubiquitin pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060386","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0000083","count":1},{"id":"GO:1903378","count":1}]},{"hash":"300553731834019529","title":"Neuronal signaling and locomotion","description":"The top GO terms are dominated by nervous system functions (sensory perception of sound, tachykinin receptor signaling, peripheral nervous system myelin maintenance), as well as processes tied to neural secretion and movement (dense core granule exocytosis, microtubule-based movement, adult locomotory behavior). While a few terms touch on other systems, the central theme points to neural signaling and motility. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:1904261","count":3},{"id":"GO:0007605","count":3},{"id":"GO:0051146","count":3},{"id":"GO:0007217","count":3},{"id":"GO:0016477","count":3}]},{"hash":"332922534315982067","title":"Unknown","description":"The GO terms are diverse and scattered across muscle development, intestinal glucose absorption, TGF-beta signaling, and microglial cell migration, with no clear shared function or cohesive pathway tying the proteins together (edges are also zero), so a precise, representative label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903526","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0001951","count":1},{"id":"GO:0010925","count":1},{"id":"GO:0071560","count":1}]},{"hash":"178716087364922293","title":"Unknown","description":"The top GO terms are scattered across nuclear/cell cycle processes (regulation of cell cycle, NLS import, telomere maintenance) and neural/synaptic functions (postsynaptic density assembly, sensory perception of sound, synaptic vesicle transport), with a few signaling terms. There is no clear single theme tying these proteins together, so a unified functional label isn\u2019t supported.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007050","count":2},{"id":"GO:0006607","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0032212","count":1},{"id":"GO:0043046","count":1}]},{"hash":"808994658478669644","title":"Ubiquitin\u2013proteasome proteolysis and stress response","description":"The top GO terms point strongly to ubiquitin-dependent proteolysis, including SCF-dependent proteasomal degradation and ERAD, indicating a core proteostasis function. Several terms also touch on cell-cycle control and DNA replication initiation, suggesting coupling between proteolysis and cell-cycle regulation. Additional terms reflect neuronal oxidative stress and heavy-metal responses (methylmercury, arsenic) and circadian regulation, implying broader stress signaling connections. Together these suggest a cluster centered on proteostasis with links to stress responses and cell-cycle control.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0000083","count":2},{"id":"GO:1903378","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0030174","count":2}]},{"hash":"1516963245816798962","title":"Steroid and lipid biosynthesis","description":"Based on the top GO terms, the cluster centers on biosynthetic processes for lipids and steroid-related compounds (mycolic acid, sphingolipid, C21-steroid hormones, glucocorticoids, testosterone, androgen metabolism). While a few terms (antibiotic biosynthesis, PHB, propylene catabolism) appear, the dominant signal is lipid and steroid biosynthesis, justifying the label. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0071768","count":2},{"id":"GO:0042619","count":1},{"id":"GO:0006704","count":1},{"id":"GO:0008209","count":1}]},{"hash":"2075735154473239630","title":"mRNA decay regulation and ERK signaling","description":"This cluster is driven by GO terms tied to post-transcriptional control of gene expression\u2014deadenylation-dependent and -independent mRNA decay and regulation of cytoplasmic translation\u2014paired with growth-factor signaling terms like the ERK cascade and cellular response to EGF. Immune-related terms appear but seem secondary to the RNA stability/translation theme, with signaling pathways likely coordinating these processes. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:1900153","count":3},{"id":"GO:0042129","count":3},{"id":"GO:0098789","count":3},{"id":"GO:0002635","count":3},{"id":"GO:0070371","count":3}]},{"hash":"1195510454271040886","title":"Cilium-associated kidney development and ion transport","description":"The GO terms cluster around cilium assembly and localization, coupled with pronephros development and renal filtration, indicating kidney-related functions tied to ciliary processes. Additional terms about sodium export and potassium homeostasis suggest epithelial ion transport roles, supporting a cohesive theme of ciliated kidney development with ion handling.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":1},{"id":"GO:0045444","count":1},{"id":"GO:0061512","count":1},{"id":"GO:0048793","count":1},{"id":"GO:0097205","count":1}]},{"hash":"513729189322674508","title":"Nuclear RNA Processing and Spliceosome Assembly","description":"The top GO terms cluster around spliceosome assembly and mRNA splicing (spliceosomal complex assembly, snRNP assembly, mRNA cis splicing via spliceosome) as well as maturation of SSU-rRNA, pointing to core nuclear RNA processing and ribosomal RNA maturation; additional terms for P-body assembly and import into nucleus support a broader RNA metabolism theme.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":3},{"id":"GO:0070317","count":3},{"id":"GO:0000387","count":3},{"id":"GO:0042633","count":3},{"id":"GO:0045292","count":3}]},{"hash":"630637707596357055","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043200","count":4},{"id":"GO:0044210","count":4},{"id":"GO:0071548","count":4},{"id":"GO:0006526","count":4},{"id":"GO:0014075","count":4}]},{"hash":"269954386034482604","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061158","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0071456","count":2}]},{"hash":"823580925503586047","title":"Transmembrane transporters for xenobiotics and ions","description":"This cluster is dominated by GO terms for transporting diverse substrates across membranes, including vitamins, xenobiotics, and various ions (potassium, cobalt, molybdate), with specific references to doxorubicin transport and antibiotic response. The coherence around membrane transport across multiple substrates suggests a set of transport-related proteins with broad substrate specificity and potential roles in drug handling and ion/nutrient uptake.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0071805","count":3},{"id":"GO:0042908","count":3},{"id":"GO:0042760","count":2}]},{"hash":"1373248935769032108","title":"Post-transcriptional RNA Processing and Silencing","description":"The terms converge on mRNA maturation and regulation: splicing and spliceosome assembly, mRNA export and stabilization, regulation of poly(A) tail, translation initiation, and ncRNA/miRNA-mediated silencing. This points to a coherent post-transcriptional control module governing mRNA processing and translational regulation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006376","count":1},{"id":"GO:0006406","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0035278","count":1},{"id":"GO:0031047","count":1}]},{"hash":"84510184460745731","title":"RNA processing and splicing machinery","description":"This cluster is dominated by GO terms related to mRNA processing, including spliceosome-mediated splicing, mRNA export and stabilization, poly(A) tail regulation, and regulatory ncRNA\u2013mediated silencing, with additional hints toward translation initiation. The shared theme is RNA maturation and regulation of gene expression at multiple RNA processing stages, from splicing to translation. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3}]},{"hash":"303837824892873646","title":"Unknown","description":"The GO terms are heterogeneous, listing innate immune and dsRNA response terms alongside posts-translational modification (tyrosine sulfation, prolyl isomerization), ciliogenesis, organ identity maintenance, lipid biosynthesis regulation, and cell cycle. This lack of a single coherent functional theme makes a confident, concise label difficult.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006478","count":2},{"id":"GO:1903646","count":2},{"id":"GO:0071360","count":2},{"id":"GO:0048496","count":2},{"id":"GO:0000413","count":2}]},{"hash":"469706284635298882","title":"Embryonic morphogenesis and cell migration","description":"The top GO terms point to embryonic development processes: gastrulation, axis elongation via convergent extension, organogenesis, and various forms of cell migration, with additional development terms for pancreas and gland growth. This suggests a cohesive program of tissue morphogenesis during development, with a minor metabolic note on proline transport co-occurring. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015824","count":2},{"id":"GO:0060028","count":1},{"id":"GO:0060029","count":1},{"id":"GO:0042074","count":1},{"id":"GO:0060770","count":1}]},{"hash":"996003624387052893","title":"Complement Regulation","description":"The dominant signal is regulation of the complement system, with multiple GO terms for negative regulation of complement activation (classical and alternative pathways) and one for complement activation (lectin pathway), pointing to a role in controlling complement activity. Additional terms on integrin regulation and cell-matrix adhesion suggest this regulation occurs in extracellular/immune contexts. Thus, labeling as Complement Regulation captures the main theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0090036","count":4},{"id":"GO:0045957","count":4},{"id":"GO:0006590","count":4},{"id":"GO:0045959","count":4},{"id":"GO:0033623","count":4}]},{"hash":"87037246346305714","title":"Polyamine and protein acetylation","description":"GO terms strongly point to acetylation events, including putrescine, spermidine, and spermine acetylation as well as N-terminal peptidyl-glutamic acid acetylation, suggesting a core theme of protein and polyamine modification. Other terms (sporulation, melatonin biosynthesis, angiogenesis, arginine biosynthesis, chromatid cohesion) are more peripheral or context-specific, potentially reflecting broader regulatory roles or annotation noise. Overall, the cluster centers on acetylation-related processes and polyamine metabolism.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030435","count":3},{"id":"GO:0032920","count":2},{"id":"GO:0018002","count":2},{"id":"GO:0006526","count":2},{"id":"GO:0032919","count":2}]},{"hash":"1342137054072135511","title":"Unknown","description":"The top GO terms span highly diverse processes from different biological contexts (antibiotic and xenobiotic metabolism, cell wall and lipoteichoic acid biosynthesis, lignin and flavonoid biosynthesis, general carbohydrate metabolism, and even cell division), with no clear unifying function or interaction pattern among the four proteins. The lack of a coherent theme and no edges linking proteins justify labeling this cluster Unknown with None confidence. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":1},{"id":"GO:0071412","count":1},{"id":"GO:0052697","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0070395","count":1}]},{"hash":"436247089437610671","title":"RNA Processing and Methylation","description":"This cluster is dominated by GO terms related to RNA maturation and nucleotide modification, including rRNA processing, tRNA wobble uridine modification, tRNA methylation, and protein methylation, suggesting a shared role in RNA maturation and methylation pathways. Several other terms (metabolic biosynthesis, growth hormone signaling, and hematopoietic differentiation) appear ancillary, indicating mixed functions in the set. Overall, the strongest coherent theme is RNA processing and methylation, hence this label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":2},{"id":"GO:0002098","count":2},{"id":"GO:0006479","count":2},{"id":"GO:0030488","count":2},{"id":"GO:0000122","count":2}]},{"hash":"228732101141043268","title":"Somite Development and Somitogenesis Regulation","description":"The top GO terms highlight somite specification and regulation of somitogenesis, pointing to proteins involved in embryonic segmentation; additional terms indicate broader organogenesis (liver, midbrain, bone). The presence of transcriptional regulation terms (negative regulation of RNA Pol II) suggests these are regulatory factors coordinating developmental programs. Overall, the core theme is somitogenesis and developmental regulation, hence the name.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001757","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0001889","count":3},{"id":"GO:0014807","count":3},{"id":"GO:0030901","count":3}]},{"hash":"1133465327633043990","title":"Diverse small-molecule biosynthesis","description":"The GO terms point to a broad set of biosynthetic activities, including antibiotic and secondary metabolite production, steroid hormone and vitamin (retinal, phylloquinone) metabolism, and polymer biosynthesis, indicating a general theme of diverse small-molecule biosynthesis rather than a single pathway.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0006704","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0008207","count":4}]},{"hash":"1806329621018015926","title":"RNA and Protein Methylation","description":"Top GO terms reveal a strong emphasis on methylation and RNA modification (guanine-N7 methylation, rRNA processing, tRNA wobble uridine modification) as well as various forms of protein methylation. The presence of related biosynthetic terms is secondary, suggesting the core function of this cluster is methyltransferase\u2013 or RNA-modification\u2013related machinery.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":3},{"id":"GO:0006596","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0006364","count":3},{"id":"GO:0002098","count":3}]},{"hash":"1397526650134658723","title":"Neural development and cell migration signaling","description":"The top GO terms point to neural development and function (positive regulation of oligodendrocyte differentiation; positive regulation of dendritic spine morphogenesis; positive regulation of glutamatergic synaptic transmission) along with broad cell movement and adhesion processes (heterotypic cell-cell adhesion; T cell and germ cell migration; germ-band extension), all tied by signaling regulation (protein tyrosine kinase activity). These together suggest a cluster of proteins involved in developmental signaling that governs neural differentiation and cellular migration. Metabolic terms appear less central to the core theme.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"wound healing","top_go_terms":[{"id":"GO:0050748","count":4},{"id":"GO:0048714","count":4},{"id":"GO:0034113","count":4},{"id":"GO:0008354","count":4},{"id":"GO:0061003","count":4}]},{"hash":"1029470962827859872","title":"Transcriptional Regulation and Defense Signaling","description":"These proteins show enrichment for DNA-templated transcription and defense-related signaling (SA-mediated systemic acquired resistance) along with several signaling and metabolic processes (Notch signaling, oxaloacetate and sphinganine biosynthesis, porphyrinogen IX biosynthesis, fatty acid transport). The combination suggests a transcription-centric cluster that bridges defense gene regulation with broader metabolic and signaling roles. ","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0009862","count":3},{"id":"GO:0006107","count":3},{"id":"GO:0046511","count":3},{"id":"GO:0006782","count":3}]},{"hash":"1583687106473119242","title":"Tissue Development and Polarity Signaling","description":"The top GO terms point to development and differentiation across multiple tissues (skeletal development, inner ear receptor differentiation, epithelial polarity, endothelial differentiation) with supporting signaling and homeostatic processes (PKC signaling, redox/NO, hyaluronan synthesis). This suggests a cohesive theme of developmental differentiation and tissue organization, rather than a single pathway, though the exact tissue focus is varied. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0090036","count":1},{"id":"GO:0045197","count":1},{"id":"GO:0045602","count":1},{"id":"GO:0042491","count":1}]},{"hash":"280989159918416198","title":"Developmental fate and cell fate regulation","description":"The proteins in this cluster are enriched for GO terms involving development and cell fate decisions (mesoderm development, cell fate determination, somatic stem cell maintenance, neuron development, megakaryocyte development, and organ morphogenesis), suggesting a shared theme of developmental regulation across lineages, even though there are no direct interactions shown.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000382","count":2},{"id":"GO:0001709","count":2},{"id":"GO:0060762","count":2},{"id":"GO:0050860","count":2},{"id":"GO:0035855","count":2}]},{"hash":"78342448792292886","title":"Plant Hormone Metabolism and Fruit Ripening","description":"The terms cluster around plant hormone biosynthesis and catabolism (gibberellin, auxin), fruit ripening, and related secondary metabolism (proanthocyanidins), with some stress-response processes (hydrogen peroxide signaling, stress granule assembly). This suggests the proteins are connected to hormone-regulated development and maturation in plants, especially fruit ripening.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0010023","count":1},{"id":"GO:0009686","count":1},{"id":"GO:0032364","count":1},{"id":"GO:0045487","count":1}]},{"hash":"40992747006729096","title":"Unknown","description":"The terms span signaling (Notch) and a broad mix of metabolic and biosynthetic processes, plus metal-sulfur cluster assembly, with no single coherent function tying the four proteins together. The annotations appear scattered rather than representing a shared pathway, so a specific, representative label cannot be inferred.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007219","count":1},{"id":"GO:0097053","count":1},{"id":"GO:0043420","count":1},{"id":"GO:0042866","count":1},{"id":"GO:0008615","count":1}]},{"hash":"1449985724714228769","title":"Embryonic and placental morphogenesis","description":"Top terms point to embryo development and reproductive tissue morphogenesis (placenta, blastocyst, uterus, spleen), with regulatory processes in gene expression suggesting developmental roles. This supports a coherent theme of embryonic organ morphogenesis, including placental contexts.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060669","count":2},{"id":"GO:0045869","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0048536","count":2},{"id":"GO:1900113","count":2}]},{"hash":"1049179915406258244","title":"Ubiquitin-Dependent Proteolysis and Cell Cycle Regulation","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process and autoubiquitination) and includes cell cycle regulation, indicating proteins likely involved in ubiquitin-mediated proteolysis and cell-cycle control. Minor terms related to autophagy and JNK signaling may reflect stress-response connections.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":2},{"id":"GO:0046328","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0000055","count":2}]},{"hash":"802457435705260871","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042273","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0000465","count":1},{"id":"GO:0035073","count":1}]},{"hash":"2076315623225257482","title":"RNA Processing and Translational Regulation","description":"Cluster appears dominated by RNA metabolism and control of protein synthesis, with ribosome biogenesis, rRNA catabolic process, mRNA processing, and translational initiation regulation by eIF2 alpha phosphorylation, plus siRNA processing. These terms suggest a cohesive theme around RNA processing and regulation of translation. A few neuronal development and innate immune terms are present but seem peripheral to the main function. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:0097049","count":1},{"id":"GO:0061744","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0045087","count":1}]},{"hash":"860889497321171227","title":"Ubiquitin-Proteasome ERAD Pathways","description":"The proteins cluster around ubiquitin- and SUMO-related protein turnover via ER-associated degradation (ERAD), deubiquitination, and proteasome regulation, including autoubiquitination and signaling links such as TNF. A ribosomal subunit assembly term appears, but the dominant theme is ubiquitin-proteasome\u2013mediated quality control and degradation, with sumoylation and related regulation supporting this core function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0016579","count":3},{"id":"GO:0000028","count":3},{"id":"GO:1901799","count":3},{"id":"GO:0016925","count":3}]},{"hash":"421132580032109705","title":"RNA splicing and transcription regulation","description":"The proteins cluster around RNA processing and transcription control, with terms for RNA splicing, regulation of alternative splicing, mRNA stabilization, and positive regulation of transcription initiation; circadian rhythm regulation also ties to transcriptional control. Some unrelated terms appear, but the dominant theme is post-transcriptional processing and transcription regulation, making this label representative.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014033","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0008380","count":1},{"id":"GO:2000144","count":1}]},{"hash":"696102647370287582","title":"Regulation of glutamatergic synaptic transmission","description":"The top GO terms cluster around excitatory synaptic function and plasticity: positive regulation of excitatory postsynaptic potential, glutamatergic synaptic transmission, AMPA receptor activity, and synaptic vesicle exocytosis, along with receptor internalization and synapse organization. This points to proteins that modulate glutamatergic signaling and AMPA receptor trafficking, consistent with learning-related synaptic plasticity. Some terms appear noisy (e.g., plant gibberellin signaling), but the core theme is excitatory synaptic regulation.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007612","count":3},{"id":"GO:2000463","count":3},{"id":"GO:0051968","count":3},{"id":"GO:2000969","count":3},{"id":"GO:0031623","count":2}]},{"hash":"2255855867996257804","title":"Redox Detoxification and Oxidative Homeostasis","description":"The cluster\u2019s top GO terms are dominated by cellular oxidant detoxification and redox homeostasis, indicating a core role in managing oxidative stress and maintaining cellular redox balance. There are additional, less central hints of xenobiotic metabolism and stress-responsive signaling (glucocorticoid response, NF-kappaB regulation), but the strongest signal centers on redox balance and detoxification. Overall, the cohesive theme is redox detoxification rather than developmental processes.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0045454","count":2},{"id":"GO:0001886","count":1},{"id":"GO:0014003","count":1},{"id":"GO:0009734","count":1}]},{"hash":"2034933748315211463","title":"Neural and Muscle Development with Synapse Assembly","description":"The cluster emphasizes developmental processes related to neural/sensory tissues and muscle lineage, including inhibitory synapse assembly, inner ear auditory receptor cell differentiation, branchiomeric skeletal muscle development, myoblast fate determination, and axonal transport of mitochondria. These terms point to a shared theme of neural/sensory and muscle development and synapse formation, with a few outliers (immune response, transcription regulation by carbon sources) that may reflect broader protein roles or annotation noise. Overall, the label captures the core functional theme observed in the cluster.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:1904862","count":4},{"id":"GO:0010201","count":3},{"id":"GO:0061415","count":3},{"id":"GO:0007518","count":3},{"id":"GO:0006959","count":3}]},{"hash":"615489490381039533","title":"Unknown","description":"The top GO terms span very diverse developmental processes across different kingdoms (animal inner ear development, plant light response, nephron and floral organ development, retinal neuron differentiation, hormone signaling like gibberellin and cytokinin, mucilage production). There\u2019s no coherent shared function or pathway linking these terms in a small cluster, so the label Unknown best reflects the lack of a unifying theme. ","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048839","count":3},{"id":"GO:0010201","count":3},{"id":"GO:0072272","count":3},{"id":"GO:0048457","count":3},{"id":"GO:0072498","count":3}]},{"hash":"1893668792811378216","title":"Developmental Patterning and Organogenesis","description":"Top GO terms indicate broad developmental and organ formation processes across neural tissues (dorsal spinal cord, midbrain), cardiovascular and pancreatic development, and ciliogenesis, with supporting general cellular processes like nucleosome disassembly and insulin regulation. This suggests a general developmental theme rather than a single, cohesive pathway, so the label captures a representative, though broad, function of the cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021914","count":2},{"id":"GO:0006337","count":2},{"id":"GO:0060982","count":1},{"id":"GO:0021516","count":1},{"id":"GO:0090104","count":1}]},{"hash":"767393929144003452","title":"Immune signaling and transcriptional regulation","description":"This cluster\u2019s top GO terms are dominated by immune-related processes (T cell receptor signaling, cellular response to GM-CSF, cellular response to LPS), suggesting a shared theme of immune activation. The presence of DNA-templated transcription (and DNA replication) terms points to concurrent transcriptional regulation in response to these signals, supporting a label centered on immune signaling with transcriptional output.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050852","count":2},{"id":"GO:0097011","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1501344489463623096","title":"Deubiquitination-Regulated Immune Signaling","description":"The proteins appear to function as deubiquitinases with linkage-specific activity (K27, K48, K29) and influence histone ubiquitination, which can modulate gene expression and signaling. The GO terms point to immune regulation (negative IL-2 production, CD40 signaling, mucosal immune response, LPS tolerance) and responses to bacterial components (muramyl dipeptide). Together, this suggests a theme of ubiquitin editing shaping immune signaling and mucosal tolerance rather than classic effector responses.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032703","count":1},{"id":"GO:1990167","count":1},{"id":"GO:1901315","count":1},{"id":"GO:0002385","count":1},{"id":"GO:0071108","count":1}]},{"hash":"159102262731679838","title":"Ubiquitin-dependent innate immune signaling","description":"The GO terms show strong signals for ubiquitination and proteasomal degradation, along with innate immune pathways (NLRP3 inflammasome assembly, TLR signaling, TNF production). This suggests a coherent theme where protein turnover via ubiquitin-proteasome interactions modulates inflammatory and innate immune responses, despite a couple of peripheral terms. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0045892","count":2},{"id":"GO:0030199","count":1},{"id":"GO:0032760","count":1}]},{"hash":"1496999111699146962","title":"ER Morphology and Neuronal Development","description":"The GO terms cluster around endoplasmic reticulum tubular network formation, maintenance, and membrane organization, with accompanying neuronal development terms such as axonal fasciculation and radial glia-guided migration. This suggests a shared focus on ER architecture that supports neuronal development, though a few terms (e.g., nuclear pore assembly, steroid biosynthesis) are less central to the main theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060317","count":1},{"id":"GO:0071787","count":1},{"id":"GO:0032581","count":1},{"id":"GO:0007413","count":1},{"id":"GO:0021801","count":1}]},{"hash":"894899768282998886","title":"GTPase Signaling and Cell Migration","description":"The top GO terms are dominated by small GTPase\u2013mediated signaling (Rho, Ras), cytoskeletal remodeling (lamellipodium assembly), and cell migration, with supporting signals from related pathways and immune/developmental processes. This points to a cohesive function where these proteins regulate signaling cascades that control movement and cytoskeletal dynamics, despite some broader terms present. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0008286","count":3},{"id":"GO:0007264","count":3},{"id":"GO:0016477","count":3},{"id":"GO:0032287","count":3}]},{"hash":"1321664807802125928","title":"Neuronal signaling and membrane excitability","description":"The cluster\u2019s top GO terms center on membrane potential regulation (resting potential, potassium import), neurotransmitter handling (glutamate reuptake), and responses related to neuronal stimuli (nicotine, glucose), all of which point to neuronal signaling and excitability. Additional terms like synaptic plasticity support this theme, while a couple of unrelated terms may reflect broader annotations or incidental associations. ","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048169","count":2},{"id":"GO:0010107","count":2},{"id":"GO:0043330","count":2},{"id":"GO:0051935","count":2},{"id":"GO:0051877","count":2}]},{"hash":"612640963599419517","title":"Unknown","description":"The GO terms are scattered across diverse processes (cellular response to nitric oxide, regulation of translation initiation, ethylene signaling, oligodendrocyte development, quinone biosynthesis, GTPase activity regulation) with two obsolete annotations, and no single cohesive function or pathway emerges to tie the proteins together.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071732","count":1},{"id":"GO:0019284","count":1},{"id":"GO:1903833","count":1},{"id":"GO:0019509","count":1},{"id":"GO:0043547","count":1}]},{"hash":"1754839431720108126","title":"Unknown","description":"There is no single, cohesive theme linking the top GO terms, which span histone modification, biofilm formation, MAPK activation, diverse developmental processes (cardiac neural crest, angiogenesis), immune response to dsRNA and muramyl dipeptide, apoptotic signaling, and spindle/projecting signaling. The presence of obsolete terms and broad, unrelated functions suggests the cluster does not reflect a specific shared function, so a precise label cannot be confidently assigned.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":4},{"id":"GO:0090606","count":4},{"id":"GO:0000186","count":4},{"id":"GO:0061308","count":4},{"id":"GO:0001525","count":4}]},{"hash":"1683808288330518744","title":"Hair Keratinization Proteins","description":"The top GO terms are keratinization and hair cycle, pointing to proteins involved in hair shaft formation and keratinocyte differentiation. The cluster likely comprises keratin family or structurally related proteins engaged in hair growth cycles, fitting a coherent hair/keratinization theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031424","count":4},{"id":"GO:0042633","count":4}]},{"hash":"1303365371980313713","title":"RNA Pol II Transcription Regulation","description":"The top GO terms are dominated by RNA polymerase II\u2013driven transcription processes, including initiation, promoter clearance, transcription elongation, promoter start-site selection, and overall gene expression regulation, indicating the cluster represents factors involved in RNA Pol II transcription control (with some terms mentioning viral transcription, which still relates to Pol II\u2013mediated transcription). ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080163","count":2},{"id":"GO:0010467","count":2},{"id":"GO:0042795","count":2},{"id":"GO:0050434","count":2},{"id":"GO:0032968","count":2}]},{"hash":"1434603487598659963","title":"Sterol and lipid biosynthesis with energy metabolism","description":"These four proteins show a clear enrichment in lipid and sterol biosynthetic processes (ergosterol, cholesterol, fatty acid, ether lipid synthesis) alongside terms for aerobic respiration and proton transport, pointing to a cluster focused on membrane lipid production coupled to cellular energy metabolism. A couple of tissue-specific terms (CNS myelin maintenance, B cell chemotaxis) appear less connected and may reflect broader annotation rather than core function.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0035754","count":2},{"id":"GO:0080065","count":2}]},{"hash":"503021995978839098","title":"Unknown","description":"The terms span metabolism, immunity, vascular biology, mechanotransduction, adipogenesis, telomere maintenance, and neurotransmission, with no single dominant function across the cluster. The diversity suggests no coherent, interpretable common function to label the group, so Unknown with None confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001275","count":3},{"id":"GO:0032212","count":2},{"id":"GO:0097497","count":2},{"id":"GO:0070431","count":2},{"id":"GO:0045083","count":2}]},{"hash":"1011399294732043199","title":"Neural development and signaling","description":"The GO terms heavily point to neural-related processes, including short-term memory, neuropeptide catabolic process, and positive regulation of neural precursor cell proliferation, suggesting a cluster centered on neural development and signaling. While there are a few ECM/tissue remodeling terms (collagen catabolic process, intramembranous ossification) and a couple unrelated terms, the neural terms appear most representative of the cluster\u2019s function. Confidence: Medium","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0097067","count":1},{"id":"GO:0001913","count":1},{"id":"GO:0001957","count":1},{"id":"GO:0035593","count":1},{"id":"GO:0007614","count":1}]},{"hash":"680973869083021496","title":"Neural development and sensory function","description":"The proteins are linked to nervous system activities such as astrocyte migration, myelination, neuromuscular balance, and sensory processes (sound perception, rhodopsin biosynthesis). The multiple glycan/oligosaccharide catabolic activities and ECM remodeling terms further point to neural tissue development and maintenance. Together, these terms suggest a cluster focused on neural development and sensory function rather than a single narrow pathway.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0043615","count":3},{"id":"GO:0030207","count":3},{"id":"GO:0050885","count":3},{"id":"GO:0009313","count":3},{"id":"GO:0007605","count":3}]},{"hash":"2044982261538536041","title":"Embryonic development and organ differentiation","description":"GO terms point to developmental processes such as left-right pattern formation, placental and pancreatic cell development, and endocrine system development, suggesting a theme of tissue- and organ-specific differentiation. The presence of terms tied to basic cellular machinery (transcription regulation, splicing, cell cycle) aligns with the infrastructure needed for development. Overall, the cluster seems to group proteins involved in embryonic development and subsequent organ differentiation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":2},{"id":"GO:0032298","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1016094182539519815","title":"Dopaminergic and Adrenergic Brain Signaling","description":"The proteins cluster around neuronal signaling: dopaminergic synaptic transmission, adrenergic receptor\u2013mediated pathways, and regulation of membrane potential, with links to brain-regulated blood pressure via the brain renin-angiotensin system. While a few terms (neutrophil chemotaxis, thymocyte differentiation) are less related, the dominant theme is neuromodulatory signaling in the brain through dopamine and adrenergic pathways, including vascular tone regulation.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042391","count":4},{"id":"GO:0002035","count":3},{"id":"GO:0001963","count":3},{"id":"GO:1900453","count":3},{"id":"GO:0001994","count":3}]},{"hash":"1645774206992154882","title":"Neural synapse organization and social behavior","description":"The top GO terms point to synapse organization and plasticity (GO:0050808, GO:0097120, GO:0051835) and to social/behavioral aspects (GO:0035176, GO:0035640, GO:0071625), with related vocalization and exploration behaviors, suggesting a neural connectivity theme affecting social behavior; a weaker immune signaling term (NOD2/MDP) is present but secondary. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070433","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0071625","count":3},{"id":"GO:0032495","count":2},{"id":"GO:0003016","count":2}]},{"hash":"1147603759569486748","title":"Cardiovascular and Inner Ear Development","description":"This label reflects the dominant GO terms pointing to development of the circulatory system and heart (multicellular organism development, circulatory system development, atrial depolarization regulation, Purkinje signaling) as well as inner ear development, suggesting a coordinated developmental program for heart/circulation and otic organogenesis; a couple of terms (pain perception, aldosterone biosynthesis) appear less directly related but do not overturn the main theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0006349","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0048839","count":4},{"id":"GO:0097497","count":3}]},{"hash":"1516285140264687660","title":"Cell cycle control and chromatin organization","description":"The GO terms that recur most strongly are related to the cell cycle (mitotic cell cycle, cell population proliferation, regulation of cell cycle checkpoint) and chromatin organization, pointing to a cohesive theme of cell-cycle regulation and chromatin dynamics. A few terms (retina development, taste perception, ubiquitin-dependent ERAD) are less aligned and could reflect pleiotropy or background noise, but the dominant signal supports the cell-cycle/chromatin theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060041","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0030433","count":1},{"id":"GO:1901976","count":1}]},{"hash":"1649252815691541491","title":"Septin-mediated cell division and chromosome segregation","description":"Based on the GO terms, the proteins cluster around septin organization at the bud neck (septin ring assembly/disassembly), cell division processes (mitotic spindle orientation, sister chromatid biorientation, cohesion), and chromosome localization, with additional notes on P granule assembly and meiotic aspects. This points to a functional module in cytokinesis and chromosome segregation regulated by septins and localization control.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090219","count":1},{"id":"GO:0032186","count":1},{"id":"GO:1903863","count":1},{"id":"GO:0006470","count":1},{"id":"GO:0031107","count":1}]},{"hash":"2127539815686848694","title":"Kidney development and renal water homeostasis","description":"The top GO terms cluster around metanephric development and glomerular structures (metanephric proximal tubule development, metanephric glomerulus vasculature development, glomerular filtration) and intracellular water homeostasis, suggesting a kidney/nephron-focused function. Supporting terms like cellular response to water deprivation and cAMP reflect signaling related to renal fluid balance, while other stress-related terms may reflect broader cellular responses. Overall, the terms point to kidney development and renal water regulation as the core theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003094","count":2},{"id":"GO:0046878","count":2},{"id":"GO:0071288","count":2},{"id":"GO:0042631","count":2},{"id":"GO:0072230","count":2}]},{"hash":"1712010727025474362","title":"Perinuclear RNA Transport and Telomere Tethering","description":"The top GO terms cluster around nucleocytoplasmic transport (tRNA export, mRNA transport, import of NLS-bearing proteins) and genome organization at the nuclear periphery (telomere tethering, periphery tethering of RNA Pol II DNA). This suggests a function focused on nuclear transport coupled with perinuclear chromatin organization. Some development- or signaling-related terms appear, but they do not override the core theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006409","count":3},{"id":"GO:0000973","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0071390","count":3},{"id":"GO:0009870","count":3}]},{"hash":"838262634753756065","title":"Actin-driven mitosis and mitochondrial inheritance","description":"This cluster\u2019s top GO terms cluster around actin cytoskeleton dynamics (actin filament polymerization; postsynaptic actin cytoskeleton organization) and mitotic processes (mitotic cytokinesis; mitotic actomyosin contractile ring assembly; chromosome movement toward spindle pole). The presence of mitochondrial localization/inheritance terms further suggests coordination of mitochondrial partitioning during cell division. Taken together, the proteins likely function together to remodel actin for mitosis while ensuring proper mitochondrial distribution to daughter cells. Some terms (endocytosis regulation, gene expression regulation) may be peripheral but do not override the dominant theme.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0043486","count":3},{"id":"GO:0016344","count":3},{"id":"GO:0098974","count":3}]},{"hash":"1468374265795023429","title":"Intracellular protein trafficking and localization","description":"The GO terms cluster around protein localization and movement within the cell, including localization to telomeres and Cajal bodies, import into the mitochondrial intermembrane space, and translocation into host cytoplasm. These suggest a shared theme of intracellular protein trafficking, with other terms related to stress or immune responses likely representing contextual regulation rather than core function.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":3},{"id":"GO:0002842","count":3},{"id":"GO:0044053","count":3},{"id":"GO:0046686","count":3},{"id":"GO:0045041","count":3}]},{"hash":"228958284084914393","title":"Unknown","description":"The top GO terms span wildly different processes (ERAD/ubiquitin-mediated quality control, cell cycle and chromatin-related regulation, TGF-beta response, protein oligomerization, chromatin modification, taste perception, osteoblast differentiation, and immune defense), with no clear shared function or pathway linking the proteins. Given the absence of connections and the heterogeneity of terms, there isn\u2019t a coherent label to assign beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:1901976","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0031497","count":2}]},{"hash":"896913444566584332","title":"DNA Repair and Cell Cycle Control","description":"The top GO terms center on genome stability: G1/S transition, mitotic intra-S DNA damage checkpoint signaling, double-strand break repair in meiosis, and maintenance of trinucleotide repeats, all pointing to DNA repair and cell cycle regulation. While other terms (neuron differentiation, vascular morphogenesis, NFAT and glucocorticoid signaling, lipid A biosynthesis) are diverse, they seem peripheral to the central theme. Overall, the strongest shared function across the cluster is DNA damage response and cell cycle control.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000082","count":3},{"id":"GO:0014898","count":3},{"id":"GO:0009245","count":3},{"id":"GO:0031573","count":3},{"id":"GO:0051531","count":3}]},{"hash":"381750638341874501","title":"Unknown","description":"The top GO terms span chromatin organization, histone acetylation, and cell cycle regulation, but also include differentiation (osteoblast), immune response, taste perception, and ERAD-related terms. The set shows a heterogeneous mix with no single, cohesive functional theme tying all proteins together, so a precise, representative label cannot be determined.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:1901976","count":3},{"id":"GO:0071560","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0031497","count":3}]},{"hash":"1357004906891193768","title":"Neuronal development and cytoskeletal remodeling","description":"The terms point to neural development processes (neuron differentiation, migration, mechanosensory behavior) and cytoskeletal/microtubule functions (microtubule nucleation, mitotic spindle midzone assembly, protein polymerization), suggesting a theme of cytoskeletal remodeling during neural development and sensory function. A few terms like IL-4 response and cell cycle appear but are less central to the core theme. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0001764","count":2},{"id":"GO:1905789","count":2},{"id":"GO:0030182","count":2}]},{"hash":"1280538105901989762","title":"Unknown","description":"The GO terms span very different biological realms (light response, transcriptional control under different carbon sources, neuronal mitochondrial transport, cell morphogenesis, angiogenesis, and ROS regulation), with no single dominant function tying the proteins together. Therefore there is no clear, cohesive theme to label this cluster.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010201","count":2},{"id":"GO:0070244","count":2},{"id":"GO:0061415","count":2},{"id":"GO:0019896","count":2},{"id":"GO:0061414","count":2}]},{"hash":"1668311197383125057","title":"Organogenesis Across Tissues","description":"These proteins are linked to a broad set of developmental GO terms spanning brain regions (metencephalon, telencephalon), sensory and inner ear structures (auditory receptor differentiation, sensory perception of sound), and organogenesis in heart and pancreas, suggesting a general theme of embryonic development and tissue differentiation rather than a single specific pathway. Confidence is Moderate because the terms are diverse but coherently point to developmental processes across multiple organs.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":3},{"id":"GO:1902870","count":3},{"id":"GO:0042491","count":3},{"id":"GO:0042663","count":3},{"id":"GO:0002087","count":3}]},{"hash":"1276161074356460125","title":"One-Carbon Metabolism and Nucleotide Biosynthesis","description":"The dominant GO terms are purine nucleobase/nucleotide biosynthesis and tetrahydrofolate\u2013related steps (10-formyltetrahydrofolate biosynthesis and THF interconversion), pointing to folate-dependent one-carbon metabolism feeding nucleotide production. Some terms (neutrophil homeostasis, embryonic neurocranium morphogenesis) are less connected, and a couple are obsolete, but the core theme reflects metabolic biosynthetic pathways centered on folate and nucleotide synthesis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006164","count":2},{"id":"GO:0009257","count":2},{"id":"GO:0001780","count":2},{"id":"GO:0000105","count":2},{"id":"GO:0035999","count":2}]},{"hash":"951319256721742266","title":"Muscle contraction and ion transport","description":"The term set centers on cardiac/skeletal muscle contraction, T-tubule organization, and ion transport (potassium and proton) across membranes, suggesting a muscle physiology and ion homeostasis theme. While a few terms relate to membrane structure or sensory cell development (e.g., inner ear receptor cell development, microvillus regulation), the strongest signals are muscle function and ion transport, justifying a muscle- and ion-focused cluster label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903416","count":1},{"id":"GO:0033292","count":1},{"id":"GO:0003011","count":1},{"id":"GO:0010107","count":1},{"id":"GO:0015991","count":1}]},{"hash":"2169649718797473241","title":"Ubiquitination and ERAD-mediated protein quality control","description":"The top terms cluster around ubiquitination processes (autoubiquitination, polyubiquitination, K63-linked) and ER-associated degradation, with a note of chaperone-mediated assembly, pointing to protein quality control; the remaining terms are peripheral to this core theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0090035","count":1},{"id":"GO:0070534","count":1}]},{"hash":"856917540668612738","title":"Lipid Transport and Lipoprotein Metabolism","description":"The GO terms strongly converge on lipoprotein metabolism, cholesterol/triglyceride handling, and VLDL particle dynamics (including efflux and endocytosis regulation), suggesting these proteins function together in lipid transport and lipoprotein processing.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007186","count":1},{"id":"GO:0048261","count":1},{"id":"GO:0070328","count":1},{"id":"GO:0010916","count":1},{"id":"GO:0042157","count":1}]},{"hash":"702697284569290862","title":"Actin cytoskeleton remodeling and cell fusion signaling","description":"Enrichment centers on actin cytoskeleton remodeling (podosome assembly, barbed-end capping) and GTPase signaling, with links to membrane remodeling and cell fusion; some terms touch osteoblast differentiation. The common thread is cytoskeletal dynamics driving adhesion and fusion-related processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0071560","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0051016","count":2}]},{"hash":"1224676126836361133","title":"ERAD-associated deubiquitination","description":"This cluster is dominated by GO terms related to deubiquitination across multiple ubiquitin linkages (K48, K29, K6, and monoubiquitinated proteins) and maintenance of unfolded proteins in the ER via ERAD, pointing to a core function in ubiquitin remodeling and endoplasmic reticulum\u2013associated protein quality control. Some neural development/behavior terms appear tangentially, but do not outweigh the central theme of deubiquitination and ERAD.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904378","count":2},{"id":"GO:0010995","count":2},{"id":"GO:0071108","count":2},{"id":"GO:0021551","count":2},{"id":"GO:0060013","count":2}]},{"hash":"1306091101741035800","title":"RNA splicing and mRNA processing","description":"Explanation: The terms cluster around mRNA maturation and post-transcriptional regulation, including splicing, spliceosome assembly, mRNA export and stability, and ncRNA-mediated gene silencing.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3}]},{"hash":"544898147852753135","title":"Neurodevelopment and Protein Trafficking","description":"The cluster is enriched for developmental and neuronal guidance/migration terms (e.g., lateral motor column neuron migration, radial glia-guided migration of Purkinje cells, angiogenesis, multicellular organism growth) and for protein localization/trafficking processes (Golgi localization, regulation of protein localization to the plasma membrane, receptor-mediated endocytosis). While translation initiation terms appear, the dominant signal points to neural development and associated protein trafficking.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0097477","count":1},{"id":"GO:0001525","count":1}]},{"hash":"1880097302871742238","title":"Skeletal muscle development and myoblast regulation","description":"The top GO terms point to muscle-related processes, including myoblast fate determination, branchiomeric skeletal muscle development, negative regulation of myoblast proliferation, and denervation-associated muscle adaptation, suggesting the proteins cluster around skeletal muscle development and regulation. While there are some broader developmental terms in the list (osteoblast, ear, oligodendrocyte, nephron), the strongest signal is muscle lineage and regulation, justifying the label. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":3},{"id":"GO:0060766","count":3},{"id":"GO:0014894","count":2},{"id":"GO:0007518","count":2},{"id":"GO:0006959","count":2}]},{"hash":"1763870582543342233","title":"Neural development and axon guidance","description":"The GO terms are dominated by neural development and axon guidance processes: semaphorin-plexin signaling, chemorepulsion of branchiomotor axons, facial nerve structural organization, and anterior commissure morphogenesis, suggesting a coherent theme around nervous system patterning and axon navigation. A general transcription term and an obsolete term are present but do not overturn this neural-focused cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032197","count":1},{"id":"GO:1902287","count":1},{"id":"GO:2000305","count":1},{"id":"GO:2000535","count":1}]},{"hash":"1272607974616803507","title":"Unknown","description":"The GO terms for this cluster are diverse, including development (multicellular organism growth, hair cell differentiation), chromatin organization, DNA damage response and telomere maintenance (nucleolar chromatin organization, negative regulation of telomere maintenance in response to DNA damage, telomeric loop disassembly, DNA-templated DNA replication fidelity), and even innate immune signaling (MDA-5 signaling pathway). There isn\u2019t a single coherent function that ties these proteins together, suggesting the terms reflect a heterogeneous set of roles rather than a defined cluster function.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":2},{"id":"GO:1990700","count":2},{"id":"GO:0035315","count":2},{"id":"GO:0072719","count":2},{"id":"GO:0070816","count":2}]},{"hash":"1616045042992464517","title":"Unknown","description":"The listed GO terms span diverse processes (ubiquitination, mitochondrial ribosome assembly, translation, phosphorylation regulation, xenobiotic response, and T cell differentiation) with no single unifying function linking the proteins. Given the lack of a cohesive theme and no observed connections between members, there is no clear label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":1},{"id":"GO:0061668","count":1},{"id":"GO:0042325","count":1},{"id":"GO:0035690","count":1},{"id":"GO:0046632","count":1}]},{"hash":"1283971888969761638","title":"Tissue morphogenesis and cell migration","description":"The top GO terms cluster around developmental processes: collagen fibril organization (ECM remodeling), cell migration and substrate attachment, boundary specification and forebrain/vestibular morphogenesis, angiogenesis, and synapse organization. These collectively point to coordinated tissue development and ECM-dependent cell movement rather than a single enzymatic function. Therefore, a label emphasizing development, morphogenesis, and migration fits best.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0060116","count":3},{"id":"GO:1904237","count":3},{"id":"GO:0055072","count":3},{"id":"GO:0050808","count":3}]},{"hash":"1845937659585060817","title":"Gland and hair morphogenesis","description":"The top GO terms cluster around morphogenesis of glands (salivary gland branching/cavitation) and hair follicles, with related vascular remodeling, suggesting a shared theme of epithelial tissue development and morphogenesis across appendages. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0060445","count":2},{"id":"GO:0006058","count":2},{"id":"GO:0001974","count":2}]},{"hash":"1918718499664253983","title":"Development and tissue differentiation","description":"The cluster is best described by a developmental theme, highlighted by terms like multicellular organism growth, spermatid development, male gonad development, and osteoblast differentiation, which point to growth and differentiation across tissues. Some other terms appear incidental to this broad theme (e.g., plasminogen activation, plasmid partitioning, non-stop decay), but they do not define a single cohesive function. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035264","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0051572","count":1},{"id":"GO:0031639","count":1},{"id":"GO:0001649","count":1}]},{"hash":"1143468706302306597","title":"Epidermal and Mammary Gland Development","description":"The top GO terms point to skin-related development, including skin development, hair follicle placode formation, and mammary gland epithelial cell proliferation, suggesting a theme of epidermal/tissue morphogenesis and gland formation. While immune-related terms appear, the strongest signals align with developmental processes in skin and associated glands rather than a single immune pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0006959","count":1},{"id":"GO:0032715","count":1},{"id":"GO:0045429","count":1}]},{"hash":"714200446886559728","title":"Innate immune signaling and ubiquitination","description":"Top terms point to innate immune response and regulation of NF-kappaB activity, with supporting signals in MHC class I biosynthesis and protein ubiquitination, implying a group of proteins involved in immune signaling and post-translational regulation. While a few terms relate to development or chromatin modification, the dominant theme is immune pathway regulation and ubiquitin-mediated control. This supports a concise label centered on innate immunity and ubiquitin-related regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0060444","count":3},{"id":"GO:0045345","count":2},{"id":"GO:0045869","count":2},{"id":"GO:2000637","count":2}]},{"hash":"688042277295389366","title":"Unknown","description":"The GO terms are very diverse and do not reveal a single shared function among the three proteins; they touch on apoptosis, autophagy, development, sensory perception, and various signaling processes, making a coherent theme unlikely.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043200","count":1},{"id":"GO:0030220","count":1},{"id":"GO:0016485","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0007605","count":1}]},{"hash":"1435633634805732759","title":"Leukocyte adhesion and migration","description":"This cluster's top GO terms center on leukocyte adhesion to vascular endothelium, leukocyte migration, and regulation of cellular extravasation, with inflammatory response terms also present. The dominant signal is immune cell trafficking and endothelial interactions, despite a few ancillary terms like membrane docking or ruffle assembly that are less central. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022614","count":2},{"id":"GO:1900027","count":2},{"id":"GO:0071333","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0002438","count":2}]},{"hash":"707405889598114386","title":"Neuronal differentiation and synapse organization","description":"The dominant GO terms point to neural development and connectivity: neuron differentiation, synapse organization, positive regulation of dendrite extension, and behavioral responses to ethanol, suggesting a cluster of proteins involved in neural development and synaptic maturation. While terms like autophagy and ubiquitination appear, they seem secondary to the central neural theme. Overall, the cluster appears to represent neuronal development and synaptic assembly processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048149","count":2},{"id":"GO:0050808","count":2},{"id":"GO:0030182","count":2},{"id":"GO:0000413","count":2},{"id":"GO:0000117","count":2}]},{"hash":"1872176121283567459","title":"Epithelial Polarity and Tight Junction Assembly","description":"Top GO terms cluster around epithelial cell polarity establishment/maintenance and bicellular tight junction assembly, indicating a theme of epithelial organization. A couple of related terms about cell cycle/division are present but less dominant, while a few outliers (learning, vacuolar targeting) may reflect broader trafficking roles. Overall, the proteins likely participate in establishing and maintaining epithelial polarity and junctions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045197","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0070830","count":2}]},{"hash":"1602337745628677747","title":"Immune activation and cytokine signaling","description":"This cluster\u2019s top GO terms cluster around immune processes: regulation of cytokine production, NK cell\u2013mediated cytotoxicity regulation, immune synapse organization, hypersensitivity regulation, and STAT signaling. While a couple terms touch on unrelated areas (cilium-related/ mechanosensation), the majority point to immune activation and signaling pathways, suggesting a coherent immune-focused function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000249","count":2},{"id":"GO:0060271","count":1},{"id":"GO:0002859","count":1},{"id":"GO:0002720","count":1},{"id":"GO:0050808","count":1}]},{"hash":"1921799279454460887","title":"H/ACA snoRNP assembly and telomerase RNA processing","description":"These terms cluster around RNA modification and RNP assembly: snoRNA-guided pseudouridylation, box H/ACA snoRNP assembly, telomerase RNA stabilization and holoenzyme assembly, and concurrent involvement in ribosome biogenesis. This points to a functional group focused on H/ACA snoRNP\u2013mediated RNA processing and telomerase RNA handling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000454","count":1},{"id":"GO:0090669","count":1},{"id":"GO:0031120","count":1},{"id":"GO:1905323","count":1},{"id":"GO:1904874","count":1}]},{"hash":"1792744594751137873","title":"Immune cell development and activation","description":"Dominant signals are hematopoiesis and immune regulation (hemopoiesis, erythrocyte differentiation, hemoglobin metabolism; NK cell cytotoxicity regulation, B cell activation, IL-2 production). The inclusion of protein folding/stabilization and synapse-related terms adds some noise, but the core theme centers on blood cell development and immune function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050821","count":1},{"id":"GO:0006457","count":1},{"id":"GO:0030097","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0020027","count":1}]},{"hash":"993916935574778927","title":"Ubiquitin-Dependent ERAD and Signaling","description":"The prominent terms point to ubiquitin cycling (deubiquitination and autoubiquitination) and ER-associated degradation, with downstream involvement in stress signaling (JNK, TNF) and regulation\u2014a coherent theme of ubiquitin-dependent protein quality control and signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904378","count":3},{"id":"GO:0035523","count":3},{"id":"GO:0044313","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0023051","count":2}]},{"hash":"566602502551568594","title":"Neuronal projection and dendrite development","description":"The GO terms cluster around neuronal growth and signaling: Rac-mediated signal transduction, lamellipodium assembly, neuron projection development, and dendrite development, with related roles in translation regulation and synaptic responsiveness. Together these suggest proteins driving neurite outgrowth and cytoskeletal remodeling in neurons, shaping projections and synaptic interfaces.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016601","count":1},{"id":"GO:0050890","count":1},{"id":"GO:1903422","count":1},{"id":"GO:0097202","count":1},{"id":"GO:0051388","count":1}]},{"hash":"2153155135446568751","title":"Interferon- and cytokine-mediated antiviral response","description":"The terms cluster around type I interferon production and signaling, cellular response to interferon-alpha, and defense against virus, along with regulation of cytokines such as IL-10 and IL-2, indicating a cohesive interferon/cytokine\u2013driven antiviral immune theme; a lone bone resorption term may reflect broader immune interactions but does not dominate the function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032733","count":1},{"id":"GO:0032703","count":1},{"id":"GO:0045351","count":1},{"id":"GO:0002437","count":1},{"id":"GO:0051607","count":1}]},{"hash":"835710306726253461","title":"Unknown","description":"The GO terms span diverse processes (nervous system development, regulation of synaptic vesicle endocytosis, muscle development and sarcomere organization, spindle midzone localization, and B cell receptor signaling), with no clear shared function or pathway and no observed edges connecting proteins, so a cohesive, specific label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0072156","count":2},{"id":"GO:0035853","count":2}]},{"hash":"1610873222234272481","title":"Cell adhesion and barrier integrity","description":"The top GO terms cluster around cell-cell adhesion (homophilic adhesion, intermicrovillar adhesion) and barrier maintenance (endothelial barrier establishment, tissue adhesion in cardiac and microvilli contexts). This suggests a shared role in sustaining tissue architecture and intercellular communication, despite a few terms that are less directly connected (e.g., brain development, B cell differentiation). Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:1902910","count":2},{"id":"GO:0032912","count":2},{"id":"GO:0086073","count":2},{"id":"GO:1903142","count":2}]},{"hash":"1963112972766174107","title":"Vesicle trafficking and secretory pathways","description":"The GO terms cluster around intracellular transport and secretion (endosome-lysosome and late endosome-Golgi trafficking, dense core granule maturation, and cilium localization) with support from GTPase regulation and membrane/microvillus-related terms. This suggests a cohesive theme of vesicle trafficking and secretory processes, hence the label. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022617","count":1},{"id":"GO:0032120","count":1},{"id":"GO:0008333","count":1},{"id":"GO:0034499","count":1},{"id":"GO:0032534","count":1}]},{"hash":"1159948218541204553","title":"Chromatin Regulation and Cell Cycle Control","description":"The top GO terms cluster around nuclear processes: chromatin organization, histone acetylation, and mitotic cell cycle/regulation of cell cycle checkpoints. This suggests a shared role in controlling gene expression through chromatin state and coordinating cell division. Other terms in the list appear more as noise or secondary associations (ERAD, TGF-beta response, osteoblast differentiation, taste, defense), but the core theme supports a chromatin\u2013cell cycle focus.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:1901976","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0031497","count":1}]},{"hash":"910842955327593519","title":"Cell adhesion and neural development","description":"The top GO terms cluster around cell adhesion (homophilic cell-cell and cell-matrix adhesion), axon guidance and neural connectivity (fasciculation of sensory neuron axon, chemorepulsion in interneuron migration, synapse assembly), and Hedgehog pathway regulation, suggesting a module coordinating adhesion with neural development and connectivity. Some terms (bone mineralization, muramyl dipeptide response) appear less central, but overall the theme links adhesive interactions to neural differentiation and wiring. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007156","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0071372","count":3},{"id":"GO:0045880","count":3},{"id":"GO:0030216","count":3}]},{"hash":"1843411353065947091","title":"Ubiquitin-Dependent Antiviral Immunity","description":"The GO terms cluster around ubiquitination (protein autoubiquitination), innate immune response, antigen presentation (MHC class I biosynthesis), restriction of viral material transport and replication, and RNA silencing regulation, together suggesting a coordinated role in host antiviral defense via ubiquitin signaling and immune regulation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":2},{"id":"GO:1903762","count":2},{"id":"GO:1901253","count":2},{"id":"GO:0045345","count":1},{"id":"GO:0045869","count":1}]},{"hash":"2231540563596715764","title":"Unknown","description":"The GO terms are a diverse mix including DNA damage response (localization to double-strand break and repair), chromatid cohesion regulation, mRNA processing and ubiquitin-related processes, and unrelated CNS development terms. Because there is no consistent functional theme tying these terms together and the proteins show no interactions, there isn't a coherent label to assign.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990166","count":1},{"id":"GO:2000781","count":1},{"id":"GO:0034184","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0006397","count":1}]},{"hash":"1447783482509794693","title":"Developmental ECM remodeling and cell migration","description":"The terms cluster around collagen fibril organization, angiogenesis, synapse organization, and forebrain/slit diaphragm-related migration and adhesion, suggesting a theme of extracellular matrix remodeling guiding development and cell movement, including neural development and specialized structures like slit diaphragms.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0060116","count":2},{"id":"GO:1904237","count":2},{"id":"GO:0055072","count":2},{"id":"GO:0050808","count":2}]},{"hash":"140549235581833971","title":"GPCR Signaling via cAMP and PI Pathways","description":"This cluster's GO terms are dominated by GPCR-mediated signaling events including adenylate cyclase activation (cAMP production) and phospholipase C\u2013linked PI signaling, notably in dopamine and adrenergic receptor pathways. The presence of related terms for GTPase regulation and tissue processes like phototransduction and heart development reflects broader GPCR roles in different tissues, but the common thread is GPCR-driven second messenger signaling.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0007603","count":2},{"id":"GO:0010513","count":2},{"id":"GO:0071880","count":2},{"id":"GO:0043950","count":2}]},{"hash":"120052240254402846","title":"Immune signaling and cell trafficking","description":"Based on GO terms, the cluster shows enrichment in signal transduction pathways (Rap protein signaling; regulation of protein kinase activity; negative/ NF-kappaB signaling) and immune cell behaviors (lymphocyte aggregation; mast cell chemotaxis), suggesting a theme of immune signaling and leukocyte movement. While a few terms are more general or unrelated (mitochondrial inheritance, oligodendrocyte differentiation, endosome transport), the dominant pattern points to immune signaling and cell trafficking.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097327","count":2},{"id":"GO:0048227","count":2},{"id":"GO:0000001","count":2},{"id":"GO:0045859","count":2},{"id":"GO:0032486","count":2}]},{"hash":"2016302751615529961","title":"Tissue morphogenesis and ECM organization","description":"These proteins share GO terms centered on development and structural organization, notably collagen fibril organization, angiogenesis, slit diaphragm assembly, and morphogenesis of neural and sensory tissues, plus related cell migration and synapse organization. This points to a cohesive theme of tissue morphogenesis and extracellular matrix remodeling, despite no direct edges among them.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0060116","count":3},{"id":"GO:1904237","count":3},{"id":"GO:0055072","count":3},{"id":"GO:0050808","count":3}]},{"hash":"1263311391744454247","title":"Unknown","description":"No shared GO terms or network connections are detectable for this small cluster (edges 0, triangles 0, empty Top Terms). Without a unifying function, there is no clear theme to name, so Unknown is appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2100857817704773255","title":"ER protein targeting and ER quality control","description":"Based on the GO terms, the cluster is centered on directing newly synthesized proteins to the endoplasmic reticulum (SRP- and Sec-mediated targeting) and on ER-associated degradation and retrograde transport from ER to cytosol, i.e., ER protein sorting and quality-control processes. This suggests a cohesive module of ER targeting and proteostasis, with a tertiary developmental term likely reflecting context-specific expression. ","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0031204","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0006605","count":1}]},{"hash":"1609354684799202882","title":"Ribosome Biogenesis and Translation Fidelity","description":"This cluster centers on ribosome assembly and function: terms for translation, ribosomal small subunit biogenesis/assembly, SSU-rRNA maturation, tyrosyl-tRNA aminoacylation, and maintenance/positive regulation of translational fidelity. Together they indicate proteins involved in ribosome production and ensuring accurate translation, with related mRNA turnover processes as supporting context.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0030490","count":1},{"id":"GO:0000028","count":1},{"id":"GO:1900153","count":1}]},{"hash":"1663150556118374212","title":"mRNA splicing and post-transcriptional regulation","description":"The GO terms indicate a focus on mRNA maturation and control, including spliceosome assembly and splicing, mRNA export and stabilization, poly(A) tail regulation, translation initiation, and RNA silencing\u2014together pointing to coordinated post-transcriptional regulation of gene expression.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":3},{"id":"GO:0006406","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0035278","count":3},{"id":"GO:0031047","count":3}]},{"hash":"10123138872315909","title":"RNA processing and spliceosome assembly","description":"The cluster is dominated by RNA biogenesis functions: tRNA processing, maturation of SSU-rRNA, spliceosomal snRNP assembly, and mRNA splicing via spliceosome, with supporting terms like nuclear import and P-body\u2013related mRNA metabolism. A couple of terms (hair cycle, response to water deprivation) appear as noise, but the core theme clearly centers on RNA maturation and splicing machinery.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008033","count":3},{"id":"GO:0030490","count":2},{"id":"GO:0070317","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0042633","count":2}]},{"hash":"1840469745317734076","title":"Cardiac ion transport and contraction regulation","description":"The terms cluster around cardiac muscle function: T-tubule organization, calcium import into the sarcoplasmic reticulum, potassium and proton transport, and regulation of heart contraction and related signaling. This points to excitation-contraction coupling and ion homeostasis in cardiac tissue.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903416","count":3},{"id":"GO:0033292","count":3},{"id":"GO:0010107","count":3},{"id":"GO:1990036","count":3},{"id":"GO:0015991","count":3}]},{"hash":"2249220794709324346","title":"Unknown","description":"The GO terms attached to this cluster are highly diverse (lipid droplet organization, sepal formation, RNA biosynthesis, protein isomerization, host-virus interactions, UV response, symbiont entry) and there is no shared pathway or clear functional theme; with zero edges and no cohesive signal, a reliable, specific label cannot be inferred from the data.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":1},{"id":"GO:0048453","count":1},{"id":"GO:0006278","count":1},{"id":"GO:0000413","count":1},{"id":"GO:0010849","count":1}]},{"hash":"1017565515870352332","title":"Cardiac Ca2+/K+ handling and T-tubule organization","description":"This cluster centers on ion transport relevant to heart function: calcium import into the sarcoplasmic reticulum, potassium import and homeostasis across membranes, and T-tubule organization, all key to cardiac excitation-contraction coupling. The presence of terms relating to negative regulation of heart contraction and hypertrophy further supports a cardiac regulatory module tied to ion handling and contractile signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903416","count":3},{"id":"GO:0033292","count":3},{"id":"GO:0010107","count":3},{"id":"GO:1990036","count":3},{"id":"GO:0015991","count":3}]},{"hash":"1835312992807578546","title":"Mitochondrial Translation Machinery","description":"The top GO terms cluster around translation with explicit mitochondrial context (mitochondrial translation and termination) and ribosomal subunit assembly, indicating proteins involved in mitochondrial protein synthesis and ribosome assembly rather than general cytosolic translation.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0032543","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0006415","count":1},{"id":"GO:0070126","count":1}]},{"hash":"1477911945959022011","title":"Unknown","description":"The GO terms span several unrelated biological areas (hemocyte differentiation, mRNA export, translation initiation, RNA silencing, energy homeostasis, meiotic cell cycle processes, flowering/photoperiodism, and general differentiation), with no clear common function or pathway tying them together. The scant connectivity (one edge, no triangles) supports this as a heterogeneous cluster without a single coherent theme.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042386","count":1},{"id":"GO:0006406","count":1},{"id":"GO:2000507","count":1},{"id":"GO:1905537","count":1},{"id":"GO:0098789","count":1}]},{"hash":"1346142280677116570","title":"Unknown","description":"The top GO terms show a broad, unrelated mix (lipid droplet organization, sepal formation, RNA-templated DNA biosynthesis, protein isomerization, host\u2013pathogen interactions, UV response), with no common biological process or molecular function across the three proteins or the added members. The lack of coherent theme and the presence of obsolete terms suggest this cluster does not represent a single functional group.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":1},{"id":"GO:0048453","count":1},{"id":"GO:0006278","count":1},{"id":"GO:0000413","count":1},{"id":"GO:0010849","count":1}]},{"hash":"1943927643314413427","title":"Cardiac Ion Transport and Contraction Regulation","description":"This cluster centers on ion transport (potassium, calcium, proton) across membranes, plus T-tubule organization and activity-related regulation of heart contraction and hypertrophy. The combination of membrane ion homeostasis and negative regulation of cardiac function points to cardiac excitation-contraction coupling mechanisms as the shared theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903416","count":2},{"id":"GO:0033292","count":2},{"id":"GO:0010107","count":2},{"id":"GO:1990036","count":2},{"id":"GO:0015991","count":2}]},{"hash":"1545998048716779808","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0034476","count":1},{"id":"GO:0032727","count":1},{"id":"GO:0006306","count":1}]},{"hash":"572086567170359030","title":"Cell-Cell Adhesion Molecules","description":"This cluster is dominated by GO terms on cell\u2013cell adhesion (both homophilic and heterophilic) and related junctional communication, with supporting signals from nervous system development and specific cardiac tissue adhesion terms. The strongest common thread is proteins that mediate intercellular contacts, i.e., adhesion molecules involved in neural and heart tissue contexts.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0007157","count":2},{"id":"GO:0043931","count":2},{"id":"GO:1902910","count":1},{"id":"GO:0032912","count":1}]},{"hash":"529119954312782774","title":"Metanephric Kidney Tubule Development","description":"The top GO terms are strongly centered on kidney morphogenesis, especially mesonephric duct development and metanephric proximal/distal tubule development, suggesting the proteins are linked to kidney tubule formation. Some immune-related and cellular stress terms appear, likely due to multifunctional annotations, but the dominant theme is kidney development. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":3},{"id":"GO:0038094","count":3},{"id":"GO:0072287","count":3},{"id":"GO:2000502","count":3},{"id":"GO:0071226","count":3}]},{"hash":"56388427934102505","title":"Embryonic organogenesis and neural development","description":"The Top Terms show broad developmental processes across nervous system structures (metencephalon, telencephalon, spinal cord) and various organs (heart, pancreas, digits, ureteric bud), indicating proteins participate in embryonic organogenesis and neural differentiation rather than a single pathway.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":3},{"id":"GO:1902870","count":3},{"id":"GO:0042663","count":3},{"id":"GO:0002087","count":3},{"id":"GO:0021978","count":3}]},{"hash":"184701033459353526","title":"Multi-tissue Development and Differentiation","description":"Top terms cluster around developmental differentiation across tissues (muscle, neural, sensory, kidney). Some terms (humoral immune response, light signaling, carbon-source transcription regulation) appear peripheral, suggesting the core theme is multi-tissue development.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0010201","count":3},{"id":"GO:0061415","count":3},{"id":"GO:0007518","count":3},{"id":"GO:0006959","count":3},{"id":"GO:0019896","count":3}]},{"hash":"1353188633516837694","title":"Unknown","description":"The top GO terms span spleen development, drug and LPS responses, prostaglandin and fatty acid metabolism, and copper ion/oxidation-related processes, many of which are disparate or obsolete. There is no clear, single functional theme linking these proteins, so a specific label isn\u2019t justifiable beyond Unknown.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0048536","count":2},{"id":"GO:0097327","count":1},{"id":"GO:0006693","count":1},{"id":"GO:0032496","count":1},{"id":"GO:0046688","count":1}]},{"hash":"1555491064006608933","title":"Unknown","description":"The GO terms span antibiotic biosynthesis, plant secondary metabolite biosynthesis (genistein, quercetin), xenobiotic metabolism, broad carbohydrate metabolism, and cell wall-related processes, covering bacteria and plants with little cohesive function. There isn\u2019t a single clear theme tying these terms together, so a specific label isn\u2019t justifiable.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0071412","count":2},{"id":"GO:0052697","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0070395","count":2}]},{"hash":"776486723008689058","title":"Unknown","description":"The listed GO terms are highly diverse, spanning xenobiotic metabolism and response to ethanol, along with potassium ion transport, cholinergic synaptic transmission, and nitric oxide biosynthesis. There is no clear, single biological process or function that unifies these terms for this cluster, so a cohesive label cannot be confidently assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046196","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0045471","count":1},{"id":"GO:0006805","count":1},{"id":"GO:0006813","count":1}]},{"hash":"1063509065620007304","title":"Plant hormone biosynthesis and fruit ripening","description":"This cluster centers on plant hormone production and metabolism (ethylene and gibberellin biosynthesis, auxin catabolic processes, and related hormone/secondary metabolite pathways) plus fruit ripening, suggesting a cohesive role in plant development and maturation. A single outlier term (penicillin biosynthetic process) does not overshadow the dominant plant-specific signals.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010023","count":1},{"id":"GO:0009686","count":1},{"id":"GO:0010421","count":1},{"id":"GO:0009852","count":1},{"id":"GO:0055114","count":1}]},{"hash":"2250556945943559854","title":"Amino acid biosynthesis and catabolism","description":"The GO terms are dominated by biosynthetic and catabolic processes for several amino acids (valine, alanine, methionine, isoleucine) and related metabolic pathways, with a few broader biosynthetic terms included. The small cluster size, absence of edges, and inclusion of obsolete terms suggest a general theme around amino-acid metabolism rather than a specific single function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009099","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0035635","count":1},{"id":"GO:0046392","count":1},{"id":"GO:0006656","count":1}]},{"hash":"2252639967671244409","title":"Skeletal development and muscle organization","description":"GO terms dominated by skeletal system development, ossification, and sarcomere organization indicate a musculoskeletal function cluster, with BMP signaling and cell adhesion providing supporting context.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048661","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0030513","count":3},{"id":"GO:0007156","count":3},{"id":"GO:0046718","count":3}]},{"hash":"1621255848908247599","title":"Oxidative stress and protein homeostasis","description":"This cluster centers on cellular stress responses, including stress granule assembly and regulation of translation during stress, alongside terms tied to protein folding/maturation and oxidative conditions (oxygen homeostasis and response to vitamin E). Although several terms are obsolete, the recurring theme is maintaining protein homeostasis under stress, particularly oxidative stress, so a label focusing on stress response and protein folding provides a coherent, high-level summary.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032364","count":1},{"id":"GO:0034063","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0019511","count":1},{"id":"GO:0018401","count":1}]},{"hash":"947445131359334195","title":"Purine nucleotide salvage and metabolism","description":"The cluster is dominated by GO terms tied to purine nucleotide metabolism and salvage, including GMP/IMP/guanine salvage, adenosine and hypoxanthine biosynthesis, and PRPP-derived biosynthetic processes, indicating a coherent purine nucleotide turnover function (one incidental term for organ regeneration does not alter the main theme).","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046085","count":1},{"id":"GO:0009158","count":1},{"id":"GO:0009117","count":1},{"id":"GO:1901069","count":1},{"id":"GO:0006015","count":1}]},{"hash":"292642163777597595","title":"Potassium Ion Transport and Homeostasis","description":"Based on the top GO terms, the cluster is dominated by potassium ion homeostasis and transport (intracellular potassium ion homeostasis and potassium ion import across the plasma membrane), suggesting a cohesive function in regulating cellular potassium levels. Some related terms also touch on inner ear receptor cell development and sensory pathways, which can be connected to potassium signaling in specialized cells, but the core signal remains potassium transport.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":2},{"id":"GO:1990573","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0003011","count":1}]},{"hash":"976315843389923852","title":"Glycogen metabolism and nervous system development","description":"The top GO terms center on glycogen metabolism (glycogen biosynthetic process, glycophagy, positive regulation of glycogen catabolic process) and cellular response to sucrose, with several neural development terms (metencephalon development, telencephalon regionalization, and neural differentiation) suggesting a metabolic cluster linked to nervous system processes. This combination points to a cohesive theme around carbohydrate metabolism intertwined with neural development contexts.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071329","count":1},{"id":"GO:0061723","count":1},{"id":"GO:0005978","count":1},{"id":"GO:0045819","count":1},{"id":"GO:0022037","count":1}]},{"hash":"606121816434283930","title":"Peptidoglycan recognition and Gram-positive defense","description":"This cluster centers on innate immune sensing of bacterial cell walls, especially peptidoglycan, and mounting defenses against Gram-positive bacteria. GO terms such as peptidoglycan recognition protein signaling pathway, detection of bacterium, defense response to Gram-positive bacterium, and innate immune response indicate a cohesive role in recognizing peptidoglycan and triggering antibacterial peptides. This makes the label representative of the cluster's function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032689","count":1},{"id":"GO:0006965","count":1},{"id":"GO:0009253","count":1},{"id":"GO:0016045","count":1},{"id":"GO:0009254","count":1}]},{"hash":"167730376738957610","title":"Embryonic nervous system and organ development","description":"GO terms are dominated by developmental processes related to nervous system and sensory organs (metencephalon, telencephalon regionalization, inner ear auditory receptor cell differentiation, sensory perception of sound), with additional entries for heart and pancreatic development and general endodermal fate regulation. This points to a common theme of embryonic organogenesis with a nervous system emphasis, though an outlier term about host-mediated suppression of viral transcription reduces cohesiveness.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022037","count":3},{"id":"GO:1902870","count":3},{"id":"GO:0042491","count":3},{"id":"GO:0042663","count":3},{"id":"GO:0002087","count":3}]},{"hash":"1138198687693728451","title":"Nucleotide Metabolism","description":"Most terms point to nucleotide phosphorylation and biosynthesis (ADP/AMP/CDP, GTP, NAD+), as well as cofactor biosynthetic processes, which unites these proteins under nucleotide metabolism. The brain development term seems incidental. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0046940","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0015937","count":3},{"id":"GO:0046041","count":3},{"id":"GO:0009435","count":3}]},{"hash":"1856019843238643815","title":"Steroid hormone and prostaglandin biosynthesis","description":"Based on the GO terms, the proteins cluster around lipid hormone metabolism, with multiple terms pointing to prostaglandin biosynthesis and steroid hormone processes (androgen, progesterone, aldosterone) via omega-hydroxylase P450 pathways. While other terms (stress response, endothelial adhesion) appear, the dominant theme is lipid mediator production and metabolism, justifying a label centered on steroid and prostaglandin biosynthesis.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":1},{"id":"GO:0097267","count":1},{"id":"GO:0033076","count":1},{"id":"GO:0008585","count":1},{"id":"GO:0035902","count":1}]},{"hash":"1919984661395080558","title":"Unknown","description":"The top GO terms are a mix of immune signaling, development, plant tropisms, and obsolete entries, with no clear shared function or pathway linking the proteins. There are no edges or coherent clustering signals to define a meaningful theme, so a reliable label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000176","count":2},{"id":"GO:1900477","count":2},{"id":"GO:0072156","count":2},{"id":"GO:0045496","count":2},{"id":"GO:0050853","count":2}]},{"hash":"1239127212440877970","title":"Developmental transcriptional regulation via ubiquitination","description":"The top GO terms cluster around developmental processes (sex comb development, ventral cord development, rostrocaudal neural tube patterning) and regulatory signaling (JNK cascade, TNF signaling) together with transcriptional control (negative regulation of transcription by RNA Pol II) and ubiquitination events (histone H2A-K119 monoubiquitination, protein autoubiquitination). This suggests a group of proteins that influence development through transcriptional regulation and ubiquitin-mediated signaling. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0045498","count":2},{"id":"GO:0036353","count":2},{"id":"GO:0007419","count":2},{"id":"GO:0046328","count":2}]},{"hash":"1802160652080842975","title":"Embryonic heart and kidney development","description":"The strongest recurring signals are developmental processes related to organ formation, including angiogenesis, cardiac neural crest\u2013driven heart development, and pronephric nephron differentiation, pointing to embryonic heart and kidney development as the core theme. The presence of unrelated immune and stress response terms appears incidental rather than defining the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":3},{"id":"GO:0090606","count":3},{"id":"GO:0000186","count":3},{"id":"GO:0035778","count":3},{"id":"GO:0001525","count":3}]},{"hash":"248845114048789514","title":"Ubiquitin-Dependent Proteolysis and Death Signaling","description":"The prominent GO terms center on ubiquitin-dependent protein catabolism, including autoubiquitination and ERAD, and on TNF-mediated signaling and necroptotic regulation. This points to a core function in ubiquitin-proteasome\u2013driven protein turnover coupled to death-related signaling pathways and growth regulation, justifying a label that highlights both degradation and stress-response signaling.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":2},{"id":"GO:0071157","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0051865","count":1}]},{"hash":"2014876790897570006","title":"Ubiquitin-dependent TNF signaling","description":"Top GO terms include ubiquitination (polyubiquitination, autoubiquitination) and TNF signaling (tumor necrosis factor-mediated signaling, its positive regulation), suggesting a cohesive theme around how ubiquitin modifications regulate TNF-driven immune responses. Although a couple of terms are less directly linked, the strongest shared signal is ubiquitin-dependent regulation of TNF signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0009896","count":2}]},{"hash":"2008954646603782519","title":"Unknown","description":"Top terms are broad and span development (angiogenesis, cardiac neural crest\u2013related heart development), immune/stress responses (dsRNA, muramyl dipeptide), signaling (MAPKK activity, filamentous growth), sensory processes (sound perception), and histone phosphorylation. The diversity and presence of obsolete terms prevent a cohesive, shared function for all proteins in this cluster, so a single specific label is not justified.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033129","count":3},{"id":"GO:0090606","count":3},{"id":"GO:0000186","count":3},{"id":"GO:0061308","count":3},{"id":"GO:0001525","count":3}]},{"hash":"2243550433402307035","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0014883","count":2},{"id":"GO:0051481","count":2},{"id":"GO:0014886","count":2},{"id":"GO:0000467","count":1}]},{"hash":"1059331834884524911","title":"Ubiquitin-dependent ERAD and TNF signaling","description":"The top terms center on ubiquitination and ER-associated degradation (including autoubiquitination and the ERAD pathway), with several terms linking to TNF-mediated signaling. Mannose trimming in ERAD and receptor-mediated endocytosis further tie into protein quality control and signaling regulation. While other terms touch on broader cellular processes (iron transport, cytoskeletal assembly, growth regulation), the dominant theme is ubiquitin-driven ERAD and TNF signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0033209","count":2},{"id":"GO:0051865","count":2},{"id":"GO:1903265","count":2},{"id":"GO:0006898","count":2}]},{"hash":"1210792273052863337","title":"Regulation of cellular signaling and adhesion","description":"The top GO terms converge on modulating signaling and cell interactions (negative regulation of phosphorylation and NO signaling; regulation of calcium entry; receptor clustering; integrin biosynthesis). Some terms touch on tissue-specific contexts like hair follicle development or acrosome reaction, but the common thread is regulation of signaling and adhesion processes across cell types.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051798","count":3},{"id":"GO:0001558","count":2},{"id":"GO:0060046","count":2},{"id":"GO:1905431","count":2},{"id":"GO:0010751","count":2}]},{"hash":"2081663223651720824","title":"Renal morphogenesis","description":"The GO terms strongly point to kidney development and tubule morphogenesis (mesonephric duct development; metanephric proximal/distal tubule morphogenesis), suggesting the proteins are linked to renal development; other terms may reflect broader or secondary roles but kidney-related terms dominate.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":2},{"id":"GO:0038094","count":2},{"id":"GO:0072287","count":2},{"id":"GO:2000502","count":2},{"id":"GO:0071226","count":2}]},{"hash":"569005147780577445","title":"Neuronal differentiation and synaptic organization","description":"The cluster is dominated by neuronal-related GO terms\u2014neuron differentiation, synapse organization, and positive regulation of dendrite extension\u2014with supporting trafficking processes (ubiquitin-dependent endocytosis, autophagy) and protein maturation, suggesting involvement in neuronal development and synaptic maturation.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0050808","count":3},{"id":"GO:0030182","count":3},{"id":"GO:0000413","count":3},{"id":"GO:0000117","count":3},{"id":"GO:0051865","count":3}]},{"hash":"626042050593872302","title":"Amino acid starvation response and autophagy","description":"The cluster\u2019s top GO terms cluster around cellular response to amino acid starvation, regulation of TORC1 signaling, and autophagy (aggrephagy), with apoptosis also present. This points to a nutrient-stress signaling module that modulates survival via autophagy and cell fate decisions, with a few additional terms reflecting broader stress-related or developmental processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":2},{"id":"GO:1903343","count":2},{"id":"GO:0006915","count":2},{"id":"GO:1904262","count":2},{"id":"GO:0035973","count":1}]},{"hash":"1849806257147218136","title":"ER quality control and ER-to-Golgi trafficking","description":"This cluster shows GO terms centered on the secretory pathway: endoplasmic reticulum to Golgi vesicle-mediated transport, ubiquitin-dependent ERAD, and ER-associated protein quality control. Additional terms touch on post-translational targeting and protein folding/refolding, reinforcing a proteostasis/trafficking theme. A couple of terms (splicing, heat response) are peripheral given the small cluster size. Overall, the proteins are best characterized by roles in managing misfolded proteins and directing them through the ER-Golgi pathway.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0006452","count":1},{"id":"GO:0070389","count":1}]},{"hash":"1630581009350539026","title":"Unknown","description":"The top GO terms span sensory perception (vision, smell), ion transport, cAMP signaling, transcription, and some organism-specific processes (bud neck localization, meiotic regulation), with no clear single function tying all proteins together. Therefore a confident, representative cluster name cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0097271","count":3},{"id":"GO:0046007","count":3},{"id":"GO:0051447","count":3},{"id":"GO:0006351","count":3}]},{"hash":"1524119784379393102","title":"Nucleosome Assembly","description":"The top terms point to nucleosome assembly and chromatin organization (GO:0006334, related chromatin assembly terms, and histone exchange). Although some terms are obsolete, the common theme is chromatin packaging/assembly, suggesting this cluster reflects nucleosome assembly activity.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":1},{"id":"GO:0010847","count":1},{"id":"GO:0006334","count":1}]},{"hash":"2305531592422145418","title":"Adrenergic Neurocardiovascular Signaling","description":"GO terms here converge on adrenergic receptor signaling, vascular tone, cardiac contraction, dopaminergic neurotransmission, brain renin-angiotensin system, and thermogenic regulation\u2014together reflecting sympathetic autonomic control of cardiovascular function and energy balance. This cohesive theme justifies a label focused on adrenergic neurocardiovascular signaling, with temperature and neural components as supportive aspects.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002024","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0055117","count":2},{"id":"GO:0002035","count":1}]},{"hash":"2143600061113904719","title":"Plant cell wall biosynthesis and glycosylation","description":"The top GO terms cluster around plant cell wall biogenesis and polysaccharide construction (mucilage, glucuronoxylan, homogalacturonan, plant-type secondary cell wall biogenesis) and wall-associated protein glycosylation (O-linked mannose and N-acetyl-galactosamine). This points to a coherent theme of cell wall formation and wall protein glycosylation in plants, with a lone muscle regeneration term likely an outlier. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010192","count":2},{"id":"GO:0006012","count":2},{"id":"GO:0035269","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0010289","count":2}]},{"hash":"65863398694451235","title":"Plant cell wall polysaccharide biosynthesis","description":"The terms cluster around plant cell wall biosynthesis and organization, especially glucuronoxylan/hemicellulose production and secondary cell wall biogenesis; pollen exine formation and glycosylation (N-linked) align with secreted wall proteins, supporting a cohesive plant cell wall biosynthesis module.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030204","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0015012","count":2},{"id":"GO:0010584","count":2},{"id":"GO:0050650","count":2}]},{"hash":"1211681158068728564","title":"Lipid droplet storage and triglyceride metabolism","description":"The cluster centers on triglyceride storage, lipid droplet organization, triglyceride mobilization, and regulation of lipase activity, with additional links to fatty acid oxidation control and triglyceride storage regulation. This combination of GO terms strongly indicates a cohesive theme of lipid droplet dynamics and triglyceride metabolic regulation, rather than unrelated processes.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030730","count":1},{"id":"GO:0060192","count":1},{"id":"GO:0034389","count":1},{"id":"GO:0006642","count":1},{"id":"GO:0010890","count":1}]},{"hash":"2016115287811554449","title":"Kidney development and renal function","description":"The top GO terms point to kidney-related biology, especially ureteric bud branching morphogenesis (kidney development) and renal sodium ion absorption (kidney function). The other terms (circadian regulation of gene expression, respiratory system process, female pregnancy) can be linked to broader systemic or rhythm-based physiology that interacts with renal processes, but the strongest signals are clearly kidney-focused. Therefore, a concise label around kidney development and renal function best represents this cluster.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032922","count":2},{"id":"GO:0003016","count":2},{"id":"GO:0070294","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0007565","count":2}]},{"hash":"424031373475990200","title":"Unknown","description":"The top GO terms are highly diverse (DNA replication, signaling, development, immune response, angiogenesis, synaptic organization) and lack a single coherent function, plus there are no edges connecting the proteins, so no reliable shared label can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0033129","count":2},{"id":"GO:1900042","count":2},{"id":"GO:0090606","count":2},{"id":"GO:0000186","count":2}]},{"hash":"1205586505530337589","title":"Unknown","description":"The GO terms show a highly diverse mix (snRNA transcription, chromatin modification, various cell cycle and DNA repair processes, telomere dynamics, plant hormone response, and neural development) with no clear, single functional theme tying all members together, so no coherent cluster label can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009301","count":1},{"id":"GO:1901347","count":1},{"id":"GO:0009753","count":1},{"id":"GO:0010520","count":1},{"id":"GO:1990414","count":1}]},{"hash":"1179934224836739354","title":"DNA replication and repair","description":"These proteins are predominantly associated with DNA metabolism: replication (DNA replication, primer synthesis), repair, recombination, and plasmid maintenance, with additional notes on helicase regulation and DNA transformation competence. This combination suggests a core function in genome maintenance and DNA processing. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006276","count":1},{"id":"GO:0006310","count":1},{"id":"GO:0070584","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0006260","count":1}]},{"hash":"1966475586268247250","title":"Nucleosome Assembly and Chromatin Organization","description":"The terms emphasize nucleosome assembly, chromatin localization to the nucleus, and heterochromatin organization, with related histone modification references and nuclear size regulation. This suggests proteins focused on chromatin packaging and organization within the nucleus.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0080182","count":3},{"id":"GO:0071169","count":3},{"id":"GO:0097298","count":3}]},{"hash":"1686046285523568182","title":"Epidermal development and membrane repair","description":"This cluster's top GO terms center on skin biology, notably plasma membrane repair and skin development, with pigment granule transport and innate immune activity also represented. The coherence suggests an epidermal module focused on membrane maintenance, differentiation, and defense.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0045769","count":1},{"id":"GO:0009826","count":1}]},{"hash":"334308029134200444","title":"Unknown","description":"The GO terms include prostaglandin biosynthesis, regulation of angiogenesis, immune response, endocytosis, and differentiation pathways, spanning lipid signaling, vascular/immune processes, and cellular trafficking. Such breadth suggests the proteins in this cluster do not share a single cohesive function, so \"Unknown\" is appropriate.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":1},{"id":"GO:0045670","count":1},{"id":"GO:0030505","count":1},{"id":"GO:0045719","count":1},{"id":"GO:0045765","count":1}]},{"hash":"103784915139246880","title":"Drosophila developmental differentiation and axis specification","description":"The GO terms point to cell fate decisions across multiple lineages (cardioblasts, chondroblasts, hemocytes, germ-line stem cells) and axis specification during embryonic/larval development, with transcriptional regulation playing a supporting role. This suggests a broad developmental differentiation theme rather than a single molecular function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0007313","count":2},{"id":"GO:0070244","count":1},{"id":"GO:0060591","count":1},{"id":"GO:0035168","count":1}]},{"hash":"1948035258597858468","title":"Neural development and TNF signaling regulators","description":"The top GO terms include central nervous system development and neural crest cell migration, suggesting a neural development theme, while several terms reference TNF signaling, T cell differentiation, and ubiquitination processes, implying broader regulatory signaling and protein turnover; due to the mixed terms and lack of interactions, the label is tentative but highlights the strongest shared themes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0045602","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0033081","count":1}]},{"hash":"1649988106481384398","title":"Developmental cell fate and lineage regulation","description":"Top GO terms indicate a broad theme of development and cell fate specification across multiple tissues (mesoderm, neurons, megakaryocytes, stem cell maintenance, branching morphogenesis). The absence of direct interactions suggests these proteins may participate in diverse developmental regulatory roles rather than a single pathway. Thus, the label captures a general developmental/regulatory theme for the cluster.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:2000382","count":3},{"id":"GO:0001709","count":3},{"id":"GO:0060762","count":3},{"id":"GO:0050860","count":3},{"id":"GO:0035855","count":3}]},{"hash":"1576803268337057381","title":"Unknown","description":"The top GO terms span several unrelated processes, including endothelial migration, various catabolic processes (nicotine, cellulose, formaldehyde, collagen), behavior, insulin secretion regulation, detoxification, T cell costimulation, and proteolysis. There isn't a single coherent function or pathway that ties these terms together, suggesting the cluster does not reflect a specific unified role.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043542","count":1},{"id":"GO:0019608","count":1},{"id":"GO:0010710","count":1},{"id":"GO:0035641","count":1},{"id":"GO:0030245","count":1}]},{"hash":"2140057570960789271","title":"Innate antiviral response and ERAD ubiquitination","description":"This cluster centers on innate immune response and defense against virus, with supporting roles for ubiquitin-dependent protein catabolic processes and TNF signaling, plus links to ERAD-related glycoprotein processing and autoubiquitination, suggesting a theme of antiviral signaling intertwined with ubiquitin-mediated degradation and ER-associated quality control. Although there are some trafficking-related terms, the dominant signal is antiviral innate immunity coupled with ubiquitin/ERAD mechanisms.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0033209","count":1}]},{"hash":"795748960881744608","title":"Immune activation and lymphocyte signaling","description":"Based on the GO terms, the proteins are enriched for regulation of NK cell activity, B cell activation, cytokine production (including IL-2), and immune synapse organization, indicating roles in immune cell communication and activation. While a couple of terms pertain to non-immune processes (sensory/mechanical detection, cardiac depolarization), the dominant signal points to immune activation and intercellular signaling among lymphocytes. Confidence is medium due to some signaling outliers but a coherent immune theme is evident.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002859","count":1},{"id":"GO:0002720","count":1},{"id":"GO:0050871","count":1},{"id":"GO:0050808","count":1},{"id":"GO:1900042","count":1}]},{"hash":"1755523916490296597","title":"Neural development and ubiquitination","description":"The top GO terms cluster around neural development (initiation of neural tube closure, synapse assembly) and protein ubiquitination (polyubiquitination and ubiquitin ligase activity regulation), with accompanying neuronal stress and cell-cycle signals. This suggests a theme of neural development coupled with ubiquitin-mediated regulation, rather than a single, narrow function. Confidence: Medium","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903378","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0071406","count":3},{"id":"GO:0060386","count":3},{"id":"GO:1902916","count":3}]},{"hash":"1856651516664438227","title":"Tissue development and immune signaling","description":"This cluster features GO terms tied to tissue formation and differentiation (angiogenesis, keratinocyte differentiation, cardiac neural crest development) alongside immune-related responses (neutrophil clearance, response to dsRNA, response to muramyl dipeptide) and cytoskeletal remodeling (actin organization) that support cell migration and signaling. The mix suggests a overarching theme of development and immune surveillance with remodeling, so the label is representative but the heterogeneity keeps confidence at a Medium level.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":2},{"id":"GO:0097350","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0033129","count":1},{"id":"GO:0090606","count":1}]},{"hash":"1093802077761587770","title":"Ubiquitin-Mediated Chromatin and Cell Cycle Regulation","description":"This cluster centers on ubiquitin-related processes (ubiquitin-dependent pathways, autoubiquitination, histone ubiquitination) together with chromatin organization and cell-cycle activities (mitotic cell cycle, cell division, synaptonemal complex organization), suggesting a shared function in ubiquitin signaling governing chromatin state and cell cycle progression. A few terms (TLR signaling, neuron projection development) appear unrelated, likely noise. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0031497","count":1},{"id":"GO:0000278","count":1},{"id":"GO:0051865","count":1},{"id":"GO:0010390","count":1}]},{"hash":"840994321245287753","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034628","count":1},{"id":"GO:0006747","count":1},{"id":"GO:0097171","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0046444","count":1}]},{"hash":"1937170449823396491","title":"Unknown","description":"Top terms span cell cycle regulation, meiosis/spindle assembly, neural development, circadian rhythm, and chemical stress responses, together forming a broad and heterogeneous set with no single cohesive function. Therefore, no clear cluster label can be confidently assigned.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000083","count":1},{"id":"GO:1903378","count":1},{"id":"GO:0021993","count":1},{"id":"GO:0030174","count":1},{"id":"GO:0031571","count":1}]},{"hash":"911630747737564018","title":"Unknown","description":"These proteins map to a mix of steroid/hormone-related processes, cholesterol transport, and diverse developmental and signaling terms spanning both animal and plant biology (e.g., progesterone biosynthesis, LH response, circadian rhythm, shoot apical meristem, and floral organ identity). There is no single cohesive function connecting all terms, suggesting no clear common theme; thus the cluster name is Unknown with no confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006701","count":1},{"id":"GO:0032367","count":1},{"id":"GO:0080060","count":1},{"id":"GO:0071373","count":1},{"id":"GO:0042747","count":1}]},{"hash":"1686971220221614040","title":"Cell Polarity and Actin Remodeling","description":"Most terms describe cell polarity and cytoskeletal remodeling at the plasma membrane\u2014Rho signaling, actin organization, microspike assembly, cell spreading, and tight junctions\u2014along with vesicle trafficking (exocytosis, membrane tubulation). An incidental immune term (interleukin-2 production) is present but does not define the cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900042","count":3},{"id":"GO:0071963","count":3},{"id":"GO:0051666","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0035023","count":3}]}]