{"hash":"281067579443454044","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms point to ubiquitination and proteasome-mediated turnover (K48-linked ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination) with additional links to receptor turnover (Wnt receptor catabolic process) and peroxisomal protein import, which can involve ubiquitin signaling. A few terms are more peripheral (iron response, X inactivation) but can be connected to broader regulatory roles of ubiquitination. Overall, the cluster seems to group proteins involved in tagging and degrading other proteins, especially in signaling and growth contexts.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"NP_573247.2","go_terms":["GO:0038018","GO:0016558","GO:0030433","GO:0060816","GO:0051865","GO:0042787","GO:0046621","GO:1900095","GO:0070936"]},{"accession":"NP_651004.1","go_terms":[]},{"accession":"NP_001188683.1","go_terms":[]},{"accession":"NP_001189128.1","go_terms":["GO:0007413","GO:1990809","GO:0051292","GO:0060317","GO:0071788","GO:2000172","GO:0030517","GO:0071787","GO:0032581","GO:0021801","GO:0006694"]},{"accession":"NP_609249.1","go_terms":[]},{"accession":"NP_001246438.1","go_terms":[]},{"accession":"NP_610664.1","go_terms":[]},{"accession":"NP_608465.1","go_terms":[]},{"accession":"NP_722622.1","go_terms":[]},{"accession":"NP_608716.1","go_terms":["GO:0032504"]},{"accession":"NP_001163464.1","go_terms":[]},{"accession":"NP_001097245.1","go_terms":["GO:0039021"]},{"accession":"NP_001286958.1","go_terms":[]},{"accession":"NP_649102.3","go_terms":[]},{"accession":"NP_570039.1","go_terms":["GO:0055114","GO:0010039"]},{"accession":"NP_609986.1","go_terms":["GO:0055114","GO:0010039"]},{"accession":"NP_572375.1","go_terms":["GO:0051390","GO:0010496","GO:0050718","GO:0050717","GO:0072347","GO:0030727","GO:0002931","GO:0034214","GO:2000746","GO:0007440","GO:0035545","GO:0006811","GO:0072375","GO:0036098","GO:0055085"]}],"graph":[],"all_go_terms":{"GO:0060816":1,"GO:0070936":1,"GO:0038018":1,"GO:0051865":1,"GO:0016558":1,"GO:0042787":1,"GO:1900095":1,"GO:0046621":1,"GO:0030433":1,"GO:0071788":1,"GO:0060317":1,"GO:0007413":1,"GO:0032581":1,"GO:2000172":1,"GO:0021801":1,"GO:0006694":1,"GO:0030517":1,"GO:0051292":1,"GO:1990809":1,"GO:0071787":1,"GO:0032504":1,"GO:0039021":1,"GO:0010039":2,"GO:0055114":2,"GO:0006811":1,"GO:0036098":1,"GO:0050717":1,"GO:0050718":1,"GO:0034214":1,"GO:0002931":1,"GO:0007440":1,"GO:0072375":1,"GO:0051390":1,"GO:0072347":1,"GO:0010496":1,"GO:0030727":1,"GO:0055085":1,"GO:0035545":1,"GO:2000746":1},"recipe_readded":["NP_648293.1","NP_648399.2","NP_573257.1","NP_652444.1","NP_652642.2","NP_609438.1","NP_001034051.1","NP_001163331.1","NP_001286301.1","NP_523654.2","NP_477280.1","NP_652383.1","NP_609202.1","NP_728741.1","NP_610322.1","NP_650172.1","NP_650762.1","NP_001188967.1","NP_001245677.1","NP_001097945.1"]}