{"hash":"1115311795066877563","title":"ER Proteostasis and Ubiquitin Pathways","description":"Top GO terms are dominated by protein modification and turnover: protein sumoylation, deubiquitination, and ubiquitin-dependent protein catabolic processes, plus signals relating to ER-associated degradation and insertion of tail-anchored membrane proteins into the ER. Translation and ribosome maturation terms appear but are secondary. Taken together, these terms point to a cluster centered on proteostasis in the secretory pathway, i.e., how cells modify, fold, and dispose of proteins via the ER and ubiquitin system. Immune signaling term is incidental.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"members":[{"accession":"NP_573129.1","go_terms":["GO:0006310","GO:0046718","GO:0019076","GO:0075713","GO:0075732","GO:0015074","GO:0006508","GO:0039651","GO:0039657","GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0006289","GO:0034140","GO:0035523","GO:0030433","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:0016567","GO:1904021","GO:0006517","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"NP_001246412.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"NP_524756.2","go_terms":["GO:0032020","GO:0034126","GO:0021766","GO:0021764","GO:0016925","GO:0060996","GO:0032259","GO:0071805","GO:0009236","GO:0019354","GO:0009086","GO:0000103","GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0002143","GO:0032447","GO:0045116","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0045892","GO:0061504","GO:0007113","GO:0000422","GO:0051726","GO:0043085"]},{"accession":"NP_572722.2","go_terms":["GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0021764","GO:0002143","GO:0032447","GO:0045116","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0045892","GO:0061504","GO:0016925","GO:0007113","GO:0000422","GO:0051726"]},{"accession":"NP_609377.1","go_terms":["GO:0000289","GO:0010606","GO:0006397","GO:0034729","GO:0000245","GO:0048149","GO:1990108","GO:0071108","GO:0021551","GO:0051568","GO:0001662","GO:0035871","GO:0008583","GO:1904667","GO:0010995","GO:0070537","GO:0010992","GO:1904378","GO:0060013","GO:1903070","GO:0035520","GO:0035523","GO:0008343","GO:0044313","GO:1900425","GO:1901026","GO:0035192","GO:0006355","GO:0006511","GO:0006351","GO:0035616"]},{"accession":"NP_651134.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759"]},{"accession":"NP_651212.1","go_terms":["GO:0032434","GO:0006289","GO:0042177","GO:0030433","GO:0000122","GO:0045070","GO:0000715","GO:0016567","GO:0006517","GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0034140","GO:0035523","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:1904021","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"NP_610239.1","go_terms":["GO:0007023","GO:0031117","GO:0034126","GO:0014889","GO:0031122","GO:0048936"]},{"accession":"NP_610913.1","go_terms":["GO:0007113","GO:0045116","GO:0051726","GO:0038061","GO:0045892","GO:0006777","GO:0016236","GO:0034727","GO:1990592","GO:0021764","GO:0002143","GO:0032447","GO:0018192","GO:0006501","GO:0032258","GO:0009229","GO:0009228","GO:0050832","GO:2000220","GO:0044805","GO:0061504","GO:0016925","GO:0000422"]},{"accession":"NP_650922.1","go_terms":["GO:0019731","GO:0002227","GO:0006412"]},{"accession":"NP_611425.1","go_terms":["GO:0016330","GO:0031115","GO:1990108","GO:0010803","GO:0050862","GO:0018230","GO:0007023","GO:0000743","GO:0051081","GO:0043369","GO:0044091","GO:0034454","GO:0014889","GO:0031122","GO:0048491","GO:0044861","GO:0072321","GO:0042347","GO:0072383","GO:1901026","GO:0010457","GO:0048936","GO:0090063","GO:0045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