{"hash":"1016130341618392516","title":"ERAD and Ubiquitin Regulation","description":"The GO terms point to protein quality control via ubiquitin and ER-associated degradation (ERAD), including negative regulation of ERAD and ubiquitin-related deubiquitination, which suggests a proteostasis/stress-response focus. Additional terms touch on lipid droplet organization and redox homeostasis, implying a broader link between lipid metabolism, oxidative stress, and protein turnover. A few terms appear obsolete, and the small cluster size makes the signal tentative, but the strongest cohesive theme centers on ERAD/ubiquitin-regulated proteostasis and stress response.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"members":[{"accession":"NP_572784.1","go_terms":[]},{"accession":"NP_608891.1","go_terms":["GO:0034389","GO:0007253","GO:0031134","GO:1904293","GO:0031468","GO:0002814","GO:2000157","GO:0030433","GO:0061060","GO:0008219","GO:1903094","GO:0045454"]},{"accession":"NP_572346.1","go_terms":["GO:0042255","GO:0046677","GO:0000448","GO:0006412"]}],"graph":[["NP_572784.1","NP_608891.1",0.598]],"all_go_terms":{"GO:0034389":1,"GO:0007253":1,"GO:2000157":1,"GO:0030433":1,"GO:0008219":1,"GO:1903094":1,"GO:1904293":1,"GO:0031134":1,"GO:0045454":1,"GO:0002814":1,"GO:0061060":1,"GO:0031468":1,"GO:0000448":1,"GO:0042255":1,"GO:0006412":1,"GO:0046677":1},"recipe_readded":["NP_647928.1","NP_001188804.1","NP_650410.1","NP_608820.1","NP_001189206.1","NP_608981.1","NP_611094.1","NP_651460.2","NP_572504.1","NP_609286.1","NP_001189259.2","NP_722858.1","NP_476902.1","NP_001287449.2","NP_001097455.1","NP_001189261.2","NP_524466.1","NP_609583.1","NP_733433.1","NP_524463.2"]}