[{"hash":"1022299463148930989","title":"Mitochondrial dynamics and metabolism","description":"The cluster is dominated by mitochondrial-related processes: mitochondrial ribosome assembly, stress-induced mitochondrial fusion, and positive regulation of cardiolipin metabolism, pointing to mitochondrial biogenesis and membrane lipid regulation. Other terms such as ethanol metabolic process and negative regulation of cholesterol biosynthesis fit into a broader energy and lipid metabolism context within mitochondria. A few immune or neuronal signaling terms are less central but may reflect broader cellular contexts. Overall, the data suggest a mitochondria-centered functional theme.","confidence":"Medium","size":29,"edges":334,"triangles":2451,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006067","count":3},{"id":"GO:0061668","count":3},{"id":"GO:0000122","count":2},{"id":"GO:0032226","count":2},{"id":"GO:0001302","count":2}]},{"hash":"1181594678532467918","title":"Mitochondrial translation and RNA methylation","description":"The cluster centers on mitochondrial gene expression: translation, mitochondrial matrix import, and RNA/protein modification (rRNA methylation and peptidyl-lysine dimethylation), with supporting signals from aerobic respiration. While broader metabolic processes like vitamin E biosynthesis and oligosaccharide biosynthesis appear, the strongest theme ties to mitochondria-associated translation and RNA modification machinery. ","confidence":"Medium","size":29,"edges":282,"triangles":1439,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0030150","count":2},{"id":"GO:0010189","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0035902","count":2}]},{"hash":"1670624866151018619","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning translation, immune regulation, olfactory perception, metal and chemical stress responses, multiple signaling pathways, and kinase regulation, with no dominant shared function. There isn\u2019t a clear, cohesive biological theme tying all proteins together, so the cluster is best labeled Unknown.","confidence":"","size":29,"edges":406,"triangles":3654,"max_degree":28,"top_function":null,"top_go_terms":[{"id":"GO:0002182","count":29},{"id":"GO:0071638","count":29},{"id":"GO:0007608","count":29},{"id":"GO:0010044","count":29},{"id":"GO:0071364","count":29}]},{"hash":"442861564830145211","title":"DNA replication and cell cycle regulation","description":"The cluster centers on core nuclear processes, with multiple terms for DNA replication (GO:0006260), DNA repair (GO:0006281), and G1/S transition of the mitotic cell cycle (GO:0000082), indicating a cell-cycle and genome-maintenance theme. Additional signals like mRNA processing (GO:0006397) and regulation of establishment of cell polarity (GO:2000114) suggest broader nuclear function and cellular organization supportive of division. Placenta development terms (GO:0001890, GO:0001892) likely reflect genes involved in proliferative tissue development, but they do not override the main cell-cycle/dna-repair signal.","confidence":"High","size":29,"edges":62,"triangles":27,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0001890","count":5},{"id":"GO:2000114","count":5},{"id":"GO:0006260","count":4},{"id":"GO:0000082","count":3}]},{"hash":"932154953425641503","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":158,"triangles":497,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":8},{"id":"GO:0001666","count":6},{"id":"GO:0007584","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0006189","count":6}]},{"hash":"1599101239728159201","title":"Neural development and oocyte meiosis with cell-cycle control","description":"Top GO terms cluster around neural development (third ventricle development, initiation of neural tube closure) and oocyte development (oocyte maturation, spindle assembly in female meiosis I), plus ubiquitin-proteasome\u2013dependent protein catabolism and microtubule dynamics, indicating a shared theme of developmental processes tied to cell-cycle control.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021678","count":7},{"id":"GO:0031146","count":7},{"id":"GO:0021993","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0070544","count":6}]},{"hash":"1450877880751335401","title":"Vertebrate Embryogenesis and Neuronal Migration","description":"The top terms emphasize broad vertebrate development across multiple organs (brain, heart, muscle, kidney morphogenesis, organ induction) plus specific neural processes (neuron migration, motor neuron axon guidance, neural crest migration). This points to a cohesive theme of embryonic development with a strong focus on neural and organogenesis rather than a single molecular function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":8},{"id":"GO:0001759","count":8},{"id":"GO:0007519","count":8},{"id":"GO:0001764","count":8},{"id":"GO:0007275","count":8}]},{"hash":"2273465189648738295","title":"Neural development and synaptic plasticity","description":"This cluster centers on nervous-system development and activity-dependent synaptic remodeling, with GO terms for eye morphogenesis, sympathetic nervous system development, corticospinal tract morphogenesis, ephrin signaling, and long-term synaptic plasticity, along with Rac signaling regulation. While a vascular-related term appears, the dominant theme is neural morphogenesis and synaptic regulation.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048593","count":4},{"id":"GO:0048485","count":4},{"id":"GO:0021957","count":4},{"id":"GO:0051835","count":4},{"id":"GO:0048013","count":4}]},{"hash":"1201032696323993611","title":"Calcium signaling in cardiac and neural development","description":"The top GO terms cluster around calcium handling and signaling: regulation of ryanodine receptor activity and release of calcium from the sarcoplasmic reticulum, which underpin muscle contraction and intracellular signaling. Additional terms point to heart development (ventricular cardiac muscle morphogenesis) and neural growth (axonogenesis), with downstream pathways like GTPase activity and adenylate cyclase activation. The combination suggests a theme of calcium-dependent signaling shaping cardiac and neural development, with calcium involvement also linked to insulin secretion regulation.","confidence":"High","size":29,"edges":16,"triangles":3,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0061179","count":7},{"id":"GO:0097274","count":6},{"id":"GO:0007565","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0055010","count":5}]},{"hash":"323790715228389157","title":"Developmental signaling and cytoskeletal remodeling","description":"The proteins show enrichment in neural tube closure, forebrain and skeletal muscle development, and germinal center/B cell signaling, suggesting broad developmental roles across tissues. Additionally, Rho signaling and actin cytoskeleton reorganization, along with ubiquitin-dependent proteolysis and CDK activity regulation, point to coordinated signaling and cytoskeletal dynamics during development and cell cycle control.","confidence":"Medium","size":29,"edges":149,"triangles":286,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001843","count":6},{"id":"GO:0045736","count":6},{"id":"GO:0007519","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0042787","count":5}]},{"hash":"645113440141627972","title":"Inflammation and complement activation","description":"Most frequent GO terms center on inflammatory mediator production, chemokine production, and classical complement activation with activation of the membrane attack complex, pointing to an innate immune/inflammatory cluster. Metabolic terms appear ancillary, while angiogenesis and embryonic development terms may reflect broader links to inflammation and vascular biology. ","confidence":"High","size":29,"edges":2,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002532","count":15},{"id":"GO:0005975","count":15},{"id":"GO:0090197","count":15},{"id":"GO:0006032","count":15},{"id":"GO:0006958","count":10}]},{"hash":"2064481361010030772","title":"Unknown","description":"Top GO terms are a mix of immune defense and reproductive processes (bacterial/fungal defense, egg activation, eggshell formation, acrosome regulation, male germ cell proliferation) with no evident shared function or interactions, making a single cohesive label inappropriate.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":1},{"id":"GO:0019732","count":1},{"id":"GO:0019731","count":1},{"id":"GO:0050829","count":1},{"id":"GO:0007275","count":1}]},{"hash":"484303852398967477","title":"Insect chemosensory perception and pheromone detection","description":"This cluster centers on insect chemical sensing and related behaviors: multiple GO terms point to chemosensory processes (carbon dioxide and bitter taste detection, chemosensory behavior) and pheromone/ Courtship-related detection (male courtship tapping for pheromones), with supporting terms like negative phototaxis and general sensory perception, suggesting a cohesive group of proteins involved in olfactory/taste signaling and pheromone communication.","confidence":"High","size":29,"edges":9,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0003031","count":6},{"id":"GO:0031000","count":6},{"id":"GO:0017085","count":6},{"id":"GO:1901354","count":6},{"id":"GO:0050913","count":6}]},{"hash":"1059352860094310893","title":"Membrane transporters for ions and nutrients","description":"The top GO terms show a strong focus on transmembrane transport across diverse substrates (nitrate, nitrite, potassium, phosphate, arabinose, vitamins, xenobiotics, etc.), plus related metabolic context (nitrate assimilation, fucose metabolism). This pattern strongly indicates a cluster of membrane transporter proteins that mediate uptake and efflux of ions and various nutrients, rather than a single, narrow function. Confidence in this labeling is High.","confidence":"","size":29,"edges":41,"triangles":19,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":25},{"id":"GO:0071805","count":25},{"id":"GO:0035435","count":25},{"id":"GO:0015751","count":25},{"id":"GO:0006855","count":25}]},{"hash":"250510615709534827","title":"Olfactory System Development and Neural Signaling","description":"The cluster\u2019s top GO terms center on olfactory system formation (olfactory nerve formation, olfactory placode morphogenesis) and related neuronal signaling processes (presynaptic membrane organization, ERK signaling, adenosine receptor signaling). While there are also terms related to membrane modification (palmitoylation) and vacuole fusion, the olfactory development and synaptic signaling themes are most prominent, suggesting a group of proteins involved in olfactory system development and associated neuronal signaling pathways.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0018230","count":5},{"id":"GO:0042144","count":5},{"id":"GO:0048733","count":5},{"id":"GO:0021628","count":4},{"id":"GO:0071699","count":4}]},{"hash":"186306696537586352","title":"Chemosensory detection and cue-driven behavior","description":"This cluster is dominated by GO terms related to chemical sensing (CO2 detection, bitter taste, chemosensory behavior) and responses to various chemical cues (caffeine, insecticide, canavanine), plus pheromone-influenced courtship behavior. The common theme is chemosensory perception guiding behavioral responses, with a bit of related sensory navigation (negative phototaxis). Therefore, labeling as chemosensory detection and cue-driven behavior is representative.","confidence":"Medium","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003031","count":8},{"id":"GO:0031000","count":8},{"id":"GO:0017085","count":8},{"id":"GO:1901354","count":8},{"id":"GO:0050913","count":8}]},{"hash":"583067819968541620","title":"Mitochondrial Transporters and Metabolic Signaling","description":"The cluster is strongly tied to mitochondrial membrane transport and mitochondrial metabolism, with multiple terms about transmembrane transport of CoA, ornithine, magnesium, and nucleotides, plus regulatory signaling related to insulin/IGF and liver regeneration. This points to a cohesive module of mitochondrial transport activities linked to broader metabolic signaling and liver metabolic functions.","confidence":"High","size":29,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":29},{"id":"GO:0097274","count":28},{"id":"GO:0060546","count":28},{"id":"GO:0035349","count":28},{"id":"GO:0000066","count":28}]},{"hash":"1815154512249575208","title":"Chromatin Regulation and Telomere Maintenance","description":"The cluster\u2019s top GO terms mainly point to chromatin state control and genome stability, including subtelomeric heterochromatin formation, telomere maintenance via recombination, histone H2B ubiquitination, and ubiquitin chain polymerization. While other terms (development, antiviral signaling) appear, the recurrent theme is chromatin modification and telomere/genome integrity.","confidence":"High","size":28,"edges":193,"triangles":542,"max_degree":22,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0006348","count":14},{"id":"GO:0071894","count":14},{"id":"GO:0009737","count":13},{"id":"GO:0016032","count":13},{"id":"GO:0010994","count":13}]},{"hash":"536820061737578493","title":"GTPase-driven migration and transcription regulation","description":"This cluster shows strong signals for small GTPase signaling and cell migration (GO:0007264, GO:0043547) and related membrane remodeling/podosome assembly, exocytosis, and polarity (GO:0045956, GO:1903527, GO:0090162, GO:0071803), suggesting cytoskeletal remodeling during migration. It also includes DNA-templated transcription regulation (GO:0006351, GO:0006355), indicating concurrent transcriptional control. The combination points to coordinated signaling for migration and cytoskeletal dynamics with transcriptional regulation, hence this label. Confidence: Medium.","confidence":"","size":28,"edges":29,"triangles":12,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0016477","count":6},{"id":"GO:0043547","count":6},{"id":"GO:0007264","count":5},{"id":"GO:0045956","count":4}]},{"hash":"1252750926583906660","title":"Cell cycle and mitosis machinery","description":"This cluster is enriched for core cell-cycle processes and mitotic chromosome dynamics, including DNA replication (GO:0006260), mitotic chromosome condensation (GO:0007076), and microtubule severing (GO:0051013), as well as cellular processes tied to division (GO:0051301). Additional GO terms related to mRNA export and RNA Pol II transcription elongation/preinitiation complex assembly suggest coordinated gene expression during the cell cycle. Taken together, the proteins appear to function as a cohesive set governing cell division and chromosome management during mitosis.","confidence":"High","size":28,"edges":130,"triangles":165,"max_degree":17,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006406","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006368","count":2}]},{"hash":"684197038871951186","title":"Drosophila antennal and eye photoreceptor development","description":"The top GO terms point to sensory organ development in Drosophila, especially antennal and photoreceptor (eye) lineages, with additional signals of transcriptional and chromatin regulation that commonly accompany developmental programs.","confidence":"Medium","size":28,"edges":9,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007469","count":3},{"id":"GO:0045316","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0042795","count":1}]},{"hash":"326507444857721728","title":"Phospho-Signaling Regulation","description":"Most terms converge on regulation of signaling pathways and phosphorylation: regulation of protein kinase activity, peptidyl-threonine phosphorylation, and Wnt signaling, plus SMAD phosphorylation control. These suggest proteins in this cluster commonly participate in controlling signal transduction through phosphorylation events. A couple of terms (sperm DNA condensation, response to testosterone) are more specific, but can reflect broader regulatory roles or annotation noise; overall the set points to a phosphorylation-mediated signaling theme.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035092","count":1},{"id":"GO:0035093","count":1},{"id":"GO:0033574","count":1},{"id":"GO:0010862","count":1},{"id":"GO:0097421","count":1}]},{"hash":"1083168903328698138","title":"Neural projection development and cytoskeletal remodeling","description":"The top GO terms cluster around neuronal development (spinal cord development, neuron projection development) and cytoskeletal dynamics (Rho signaling, actin filament depolymerization, microtubule severing, microtubule-based movement, mitotic spindle assembly, cell division), suggesting proteins involved in shaping neural processes via coordinated actin and microtubule remodeling and signaling. While some terms are related to general cell division, the emphasis on neural development and cytoskeletal regulation indicates a cohesive neural-projection/remodeling function.","confidence":"High","size":28,"edges":4,"triangles":0,"max_degree":2,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0021510","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0030042","count":4},{"id":"GO:0071320","count":4},{"id":"GO:0070493","count":4}]},{"hash":"1110760983224841258","title":"Unknown","description":"The top GO terms cover chromatin regulation, plant development, diverse metabolic pathways, and various post-translational modifications, with no single cohesive function tying the proteins together.","confidence":"","size":28,"edges":250,"triangles":1246,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":16},{"id":"GO:0030187","count":15},{"id":"GO:0019491","count":15},{"id":"GO:2000025","count":15},{"id":"GO:0009447","count":15}]},{"hash":"435507231176991522","title":"Growth signaling and genome maintenance","description":"The top GO terms span development and growth (angiogenesis, skeletal system development), signaling (PI3K/AKT pathway), protein synthesis and processing (translation, mRNA processing, eIF2\u03b1-regulated translation), and core genome maintenance activities (DNA replication, DNA repair, chromosome separation), plus innate immune response. This pattern suggests a cluster centered on coordinating growth and development with genome maintenance and translational control, rather than a narrow, single-pathway group.","confidence":"Medium","size":28,"edges":127,"triangles":360,"max_degree":23,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001525","count":10},{"id":"GO:0006260","count":9},{"id":"GO:0006281","count":9},{"id":"GO:0006412","count":8},{"id":"GO:0051304","count":7}]},{"hash":"1382956227453872553","title":"Membrane-Targeted Protein Folding and Quality Control","description":"The cluster is dominated by GO terms related to post-translational targeting to membranes, chaperone-assisted protein refolding/maturation, and ATP-dependent activity, all core to protein quality control at membranes/mitochondria. While a couple terms refer to broader developmental processes or older annotations, the strongest signals point to membrane-associated protein folding and proteome maintenance.","confidence":"Medium","size":28,"edges":347,"triangles":2623,"max_degree":27,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031204","count":27},{"id":"GO:0090084","count":27},{"id":"GO:0070389","count":27},{"id":"GO:1900035","count":27},{"id":"GO:0006260","count":27}]},{"hash":"568982445336856248","title":"Ubiquitin-regulated development and muscle differentiation","description":"This cluster centers on ubiquitination-related processes (negative regulation of ubiquitination, ubiquitin-dependent protein catabolic process, K33-linked ubiquitination) alongside developmental terms such as smooth muscle tissue development, skeletal muscle fiber development, and distal tubule morphogenesis. The combination suggests a theme of ubiquitin-mediated regulation of development and tissue differentiation, particularly in muscle and organ morphogenesis, with some secondary signals related to circadian or immune regulation. Confidence: Medium","confidence":"","size":28,"edges":30,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0097211","count":2},{"id":"GO:0048745","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0072156","count":2}]},{"hash":"852655652253683032","title":"Cytoplasmic Translation and SRP-Dependent Targeting","description":"The top GO terms are dominated by cytoplasmic translation and SRP-dependent cotranslational protein targeting to the membrane, including signal sequence recognition, which together point to components of the translation machinery and their co-translational targeting to the endoplasmic reticulum. Additional terms like positive regulation of TOR signaling and GTPase activity align with nutrient-sensing and membrane-associated processes that influence translation, supporting a cohesive theme around protein synthesis and nascent-chain targeting. Some peripheral terms (e.g., intraciliary transport, mushroom body development) may reflect broader functional annotations but do not override the central translation/ER-targeting signal.","confidence":"High","size":28,"edges":225,"triangles":851,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0035735","count":1},{"id":"GO:0016319","count":1},{"id":"GO:0043547","count":1}]},{"hash":"2160440832882434383","title":"Innate Immune and Angiogenic Signaling","description":"The cluster\u2019s top GO terms center on innate immune response and growth-related processes, including angiogenesis, PDGF receptor signaling regulation, and developmental growth regulation, suggesting a shared theme of immune signaling interacting with vascular and growth pathways. The presence of mitotic cell cycle terms also hints at proliferation tied to immune or developmental processes, but the connections are broad rather than a single, tightly defined pathway, so the label captures the dominant theme while acknowledging complexity.","confidence":"Medium","size":28,"edges":18,"triangles":1,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":28},{"id":"GO:0000278","count":27},{"id":"GO:0071276","count":27},{"id":"GO:0000186","count":26},{"id":"GO:0010641","count":26}]},{"hash":"194703467499647561","title":"Transcriptional Regulation of Development","description":"Proteins in this cluster are enriched for transcription-related GO terms (RNA polymerase II\u2013mediated transcription, DNA-templated transcription) and a broad array of developmental differentiation processes (dendritic cell differentiation, gonad development, heart valve formation, hemangioblast differentiation, eye morphogenesis, and PNS neuron development). The common thread is transcriptional control of diverse developmental programs across multiple lineages, rather than a single pathway, justifying this label.","confidence":"High","size":28,"edges":358,"triangles":2946,"max_degree":27,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0006351","count":7},{"id":"GO:0043433","count":7},{"id":"GO:0032922","count":7},{"id":"GO:0043011","count":6}]},{"hash":"1434435465739720026","title":"Adaptive Immune Activation and T Cell Signaling","description":"This cluster is dominated by GO terms tied to adaptive immune responses and T cell activity, including T cell costimulation, interleukin-2 production, CD8+ T cell apoptosis, mast cell degranulation, and classical complement activation. Peripheral themes like nervous system development and lens morphogenesis are present but secondary to the clear immune activation signal.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":4},{"id":"GO:0045162","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0007399","count":4},{"id":"GO:0043303","count":4}]},{"hash":"2209565882828494948","title":"Iron transport and homeostasis","description":"The dominant GO terms point to iron handling: import of iron ions across the plasma membrane, intracellular iron ion homeostasis, and transferrin transport, alongside receptor-mediated endocytosis, suggesting a core role in iron uptake and intracellular trafficking. Some other terms reflect general cellular metabolism or trafficking and are less central to this theme, but the iron-related terms provide a coherent functional cluster. ","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007039","count":4},{"id":"GO:0006760","count":4},{"id":"GO:0042135","count":4},{"id":"GO:0010081","count":4},{"id":"GO:0006898","count":4}]},{"hash":"1307706445826581841","title":"Embryonic development and patterning","description":"The proteins are enriched for GO terms tied to developmental processes and patterning across tissues and organisms (left/right pattern formation, axis specification, placenta/trophoblast differentiation, cartilage morphogenesis, EMT in heart cushion, etc.). While the specific tissue contexts vary widely, the common thread is embryonic development and differentiation, suggesting a cluster of proteins involved in developmental patterning rather than a single tissue-specific function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0007311","count":3},{"id":"GO:0045998","count":3}]},{"hash":"625908688191674666","title":"Zinc ion transport and homeostasis","description":"The top GO terms cluster around zinc handling: detoxification of zinc, zinc ion import across membranes, cellular response to zinc starvation, and intracellular zinc ion homeostasis, indicating a cohesive module of zinc uptake, distribution, and regulation. Some related terms like cadmium transport appear, but the dominant theme remains zinc homeostasis, suggesting the proteins are zinc transporters/regulators. ","confidence":"High","size":28,"edges":135,"triangles":293,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":8},{"id":"GO:0044749","count":8},{"id":"GO:0034224","count":8},{"id":"GO:0006830","count":8},{"id":"GO:0006882","count":8}]},{"hash":"496896104756373551","title":"Cytokine signaling and chitin-based molting","description":"The cluster prominently features cytokine-related processes (response to interleukin-6, cellular response to interleukin-1, IL-8 production) alongside chitin-related terms (chitin catabolic process, ecdysis, chitin-based cuticle) and a general apoptotic signal, suggesting a theme of immune signaling intertwined with molting/exoskeleton remodeling, typical of arthropod biology. Some developmental terms may be broader GO annotations but do not detract from the main pattern.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070741","count":4},{"id":"GO:0030324","count":4},{"id":"GO:0009612","count":4},{"id":"GO:0000272","count":4},{"id":"GO:0071347","count":4}]},{"hash":"1293333380306171146","title":"Small-molecule catabolism and detox","description":"The top GO terms cluster around catabolic metabolism of diverse small molecules (triglycerides, uracil, alkaloids, xenobiotics like 1,2-dichloroethane) and a related detox response, with additional biosynthetic processes. This points to a shared role in broad metabolite processing and detoxification rather than a single substrate, hence the label focused on small-molecule catabolism and detox. ","confidence":"Medium","size":28,"edges":156,"triangles":260,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":24},{"id":"GO:0097755","count":15},{"id":"GO:2000124","count":15},{"id":"GO:0019260","count":15},{"id":"GO:0006212","count":15}]},{"hash":"1191636490860384835","title":"Neural development and synaptic signaling","description":"The cluster is dominated by terms tied to nervous system development and neuronal function: nervous system development, axon midline guidance, ionotropic glutamate receptor signaling, and regulation of synapse structure/activity, plus collateral sprouting. While a few terms touch on non-neural processes (placental branching morphogenesis, ER Ca2+ homeostasis), the prevailing theme is neurodevelopment and synaptic signaling, making this label representative and specific. ","confidence":"Medium","size":28,"edges":8,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":9},{"id":"GO:1990000","count":7},{"id":"GO:0048669","count":7},{"id":"GO:0035235","count":7},{"id":"GO:0060670","count":7}]},{"hash":"1987597289210946025","title":"Unknown","description":"The GO terms span immune responses (lipopolysaccharide and xenobiotic response, complement activation) and metabolic processes (brown fat differentiation, long-chain fatty acid import, insulin response), plus a mix of neural, sensory, and epithelial maintenance terms, with no clear, single shared function tying all proteins together.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0050873","count":2},{"id":"GO:0032868","count":1},{"id":"GO:0044539","count":1}]},{"hash":"2166768327662367230","title":"Insect Sleep and Cholinergic Neural Signaling","description":"The cluster shows enriched terms for sleep, circadian regulation, rhythmic processes, and regulation of cholinergic synaptic transmission, along with ion-channel activity related to acetylcholine-gated and voltage-gated potassium channels. Together, these point to a cohesive theme of neural signaling linked to insect sleep and circadian control, with a few development-related terms that may be incidental. ","confidence":"Medium","size":28,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903049","count":5},{"id":"GO:1903818","count":5},{"id":"GO:0008362","count":5},{"id":"GO:0035158","count":5},{"id":"GO:0030431","count":5}]},{"hash":"566565378017242934","title":"Cardiac potassium transport and action potentials","description":"Most GO terms are about potassium ion transport, import/export regulation, and cardiac electrical activity, including regulation of heart rate by conduction and various cardiac action potentials (AV node and atrial/ventricular). A minor outlier relates to osmotic-stress-induced apoptosis, but the dominant theme is potassium handling in cardiac electrophysiology, justifying this label as representative. ","confidence":"High","size":28,"edges":12,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":5},{"id":"GO:0086091","count":4},{"id":"GO:0086002","count":4},{"id":"GO:0098914","count":4},{"id":"GO:1990573","count":4}]},{"hash":"1651023766072640609","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":114,"triangles":197,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0051083","count":2},{"id":"GO:0006620","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0000381","count":2}]},{"hash":"2264830354682140356","title":"Mitosis and Centromere Assembly","description":"The top GO terms cluster around cell division and mitosis, including mitotic cell cycle, DNA-templated transcription (likely active transcription during division), and CENP-A containing chromatin assembly, plus microtubule severing\u2014pointing to chromosome condensation/segregation and centromere function. Additional terms about ribosomal RNA maturation and ER-Golgi transport may reflect broader nuclear biogenesis and trafficking roles, but the dominant signal is mitotic chromosome segregation and centromere assembly.","confidence":"Medium","size":27,"edges":350,"triangles":2900,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0000278","count":8},{"id":"GO:0051013","count":8},{"id":"GO:0000463","count":7}]},{"hash":"617216441729825664","title":"Protein Tyrosine Phosphatases Attenuating Signaling","description":"This cluster is dominated by GO terms for dephosphorylation of tyrosine residues and the negative regulation of major signaling pathways (TCR signaling, ERK/MAPK, and PI3K/AKT), pointing to protein tyrosine phosphatases as key regulators that dampen signaling. Additional terms related to synaptic organization suggest neuronal regulation of signaling as well, but the unifying theme is phosphatase-mediated attenuation of signaling networks.","confidence":"High","size":27,"edges":195,"triangles":817,"max_degree":22,"top_function":"autophagy","top_go_terms":[{"id":"GO:0050860","count":15},{"id":"GO:0070373","count":15},{"id":"GO:0000200","count":15},{"id":"GO:0035335","count":15},{"id":"GO:0051898","count":14}]},{"hash":"230761139380733286","title":"Yeast DNA damage response and telomere maintenance","description":"The cluster is best described by yeast-specific stress and DNA maintenance activities. Top GO terms include cellular response to toxic substances and to DNA-damaging agents like hydroxyurea and cisplatin, along with DNA-templated transcription and protein phosphorylation regulation, and notably telomere maintenance via recombination and mating type switching, which are hallmark processes in Saccharomyces species. Together these terms indicate a functional theme around DNA damage response, transcriptional control, and telomere maintenance in yeast.","confidence":"Medium","size":27,"edges":249,"triangles":1265,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0009636","count":5},{"id":"GO:0072711","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0001932","count":5},{"id":"GO:0072719","count":5}]},{"hash":"1142987811104994028","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":344,"triangles":2758,"max_degree":26,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090307","count":9},{"id":"GO:0000462","count":8},{"id":"GO:0006351","count":8},{"id":"GO:0000472","count":8},{"id":"GO:0000480","count":8}]},{"hash":"542186298202588262","title":"Insect olfaction and pheromone detection","description":"These terms cluster around chemosensory perception in insects\u2014odor/pheromone detection, olfactory behavior, CO2 sensing, and related chemical-stimulus responses. The proteins likely participate in insect chemosensation and pheromone signaling, so the label reflects the dominant function. ","confidence":"High","size":27,"edges":172,"triangles":770,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":8},{"id":"GO:0042048","count":8},{"id":"GO:0050911","count":8},{"id":"GO:0043695","count":8},{"id":"GO:0007608","count":8}]},{"hash":"997986010930664411","title":"Spliceosome-driven mRNA splicing and stability regulation","description":"The terms cluster around mRNA processing via the spliceosome, including cis- and alternative splicing, splicing regulation, and mRNA stabilization, plus processome assembly and ncRNA-mediated gene silencing, indicating a cohesive post-transcriptional regulation module.","confidence":"High","size":27,"edges":110,"triangles":203,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":9},{"id":"GO:0010610","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0031047","count":8},{"id":"GO:1901407","count":8}]},{"hash":"1839972018130254055","title":"Embryogenesis: patterning and morphogenesis","description":"This cluster shows a concentration of GO terms related to early development and tissue formation, including left-right patterning, dorsal/ventral axis specification, EMT, cartilage morphogenesis, and placental/trophoblast differentiation, along with some proliferation-related terms (DNA replication, mitotic cell cycle). The common thread appears to be developmental patterning and morphogenesis across tissues, with species-spanning processes. Confidence: Medium","confidence":"","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0007311","count":3},{"id":"GO:0045998","count":3}]},{"hash":"1981823637201017652","title":"Neuron Axon Guidance and Cell Migration","description":"Based on the top GO terms, the proteins cluster around migratory processes, especially neuron/axonal guidance (motor neuron axon guidance) and general cell migration (fibroblast migration, cell migration), with supporting roles in actin cytoskeleton dynamics and signaling that regulate movement and transcriptional programs. This suggests a coherent migratory/axonal guidance module rather than a purely metabolic or transcriptional category.","confidence":"High","size":27,"edges":14,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016477","count":7},{"id":"GO:0031532","count":7},{"id":"GO:0006351","count":7},{"id":"GO:0033138","count":7},{"id":"GO:0008045","count":6}]},{"hash":"319029716030983654","title":"Ribosome biogenesis and translation machinery","description":"This cluster centers on ribosome production and function: strong signals for ribosome biogenesis, rRNA transcription by RNA Pol I, tRNA transcription by RNA Pol III, Pol II transcription, RNA-templated transcription, nucleologenesis, and translation, all pointing to the framework of ribosome assembly and protein synthesis. The angiogenesis and cell size terms are less central but may reflect broader regulatory connections; overall the theme is the ribosome/translation apparatus.","confidence":"High","size":27,"edges":60,"triangles":46,"max_degree":10,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0042254","count":5},{"id":"GO:0042790","count":3},{"id":"GO:0006366","count":3},{"id":"GO:0042797","count":3}]},{"hash":"356928909604444948","title":"Microtubule Assembly and Protein Quality Control","description":"This cluster centers on cytoskeletal dynamics and protein homeostasis, with enrichment for tubulin complex assembly and cortical microtubule organization, along with chaperone-mediated assembly and ubiquitin-proteasome\u2013based quality control. Trafficking-related terms (anterograde synaptic vesicle transport, lysosome localization) further support a theme of cytoskeletal\u2013driven intracellular transport and proteostasis. While some transcription-related terms appear, the dominant pattern ties microtubule establishment to protein folding and degradation processes.","confidence":"Medium","size":27,"edges":263,"triangles":1408,"max_degree":26,"top_function":"protein folding","top_go_terms":[{"id":"GO:0007021","count":5},{"id":"GO:0006457","count":4},{"id":"GO:0032968","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0043622","count":3}]},{"hash":"891011023411755215","title":"Metal Ion Transport and Heme Biosynthesis","description":"This cluster centers on metal ion transport terms (zinc, copper, cadmium) and calcium ion homeostasis, along with protoporphyrinogen IX biosynthetic process, which together point to metal handling and heme metabolism. A few other terms (testosterone response; negative regulation of smoothened signaling) appear peripheral to this core theme.","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006782","count":4},{"id":"GO:0016311","count":3},{"id":"GO:0045879","count":3},{"id":"GO:0097755","count":3},{"id":"GO:0006874","count":3}]},{"hash":"506349707438351464","title":"Golgi Trafficking and Cell Polarity in Mitosis","description":"The cluster centers on Golgi-related processes (Golgi vesicle budding, Golgi localization) and cytoskeletal/polarity dynamics (actin/cytoskeleton remodeling, cell polarity maintenance), alongside mitotic functions (spindle assembly, mitotic cell cycle). This pattern suggests a cohesive role in coordinating Golgi-dependent trafficking with polarity and division, with some members linked to vascular morphogenesis and synaptic plasticity as broader cellular contexts.","confidence":"Medium","size":27,"edges":46,"triangles":57,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048194","count":5},{"id":"GO:0031532","count":5},{"id":"GO:0051291","count":5},{"id":"GO:0090307","count":5},{"id":"GO:0097498","count":5}]},{"hash":"1247480341902169143","title":"Plant development and light-response signaling","description":"Most terms point to plant-specific processes such as maintenance of meristem identity and photosystem stoichiometry adjustment, complemented by signaling regulation (peptidyl-threonine dephosphorylation, nuclear export) and cross-kingdom growth signaling terms. The cluster appears to group proteins involved in growth regulation and environmental response via signaling networks in plants.","confidence":"Medium","size":27,"edges":228,"triangles":1204,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0035970","count":12},{"id":"GO:0080005","count":12},{"id":"GO:0010074","count":12},{"id":"GO:0071560","count":12},{"id":"GO:0000173","count":12}]},{"hash":"1768522305918584106","title":"Wnt-Ephrin Synaptic Signaling","description":"The top GO terms center on receptor-mediated signaling related to neural function: Wnt signaling (GO:0016055), regulation of ephrin receptor signaling (GO:1901187), and regulation of synaptic plasticity via receptor localization to the synapse (GO:1900383), with calcium release into the cytosol (GO:0051209) fitting into synaptic signaling cascades. Some terms reflect broader sensory or cell-cycle processes, but the core theme appears to be neuronal signaling and development through Wnt/ephrin pathways, with potential secondary developmental context. Overall, the cluster represents synaptic signaling pathways influenced by receptor localization and calcium dynamics.","confidence":"Medium","size":27,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":4},{"id":"GO:0060743","count":4},{"id":"GO:0016055","count":4},{"id":"GO:1901187","count":4},{"id":"GO:0051209","count":3}]},{"hash":"1911664956014534538","title":"RNA Splicing and Deubiquitination","description":"The top GO terms center on mRNA splicing via the spliceosome and mRNA decay, with notable coverage of protein deubiquitination (including K27- and K11-linked), indicating a cluster tied to RNA processing and ubiquitin-mediated regulation. There are additional terms for apoptosis and transcriptional regulation, but the strongest signals point to splicing and deubiquitination processes as the core theme.","confidence":"High","size":27,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000288","count":2},{"id":"GO:0031086","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0016579","count":2}]},{"hash":"1577516421221895591","title":"Embryogenesis and organ morphogenesis with transcriptional regulation","description":"The cluster is enriched for DNA-templated transcription and circadian regulation of gene expression, alongside multiple embryonic and organ development terms (in utero embryonic development, embryonic eye morphogenesis, cardiac muscle cell proliferation, trachea cartilage development, Harderian gland development). This points to a cohesive theme of developmental gene-expression programs governing organogenesis, supported by transcriptional regulation. ","confidence":"High","size":27,"edges":202,"triangles":713,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043433","count":9},{"id":"GO:0006351","count":9},{"id":"GO:0032922","count":9},{"id":"GO:0060534","count":8},{"id":"GO:2000020","count":8}]},{"hash":"1452539801516195026","title":"Sphingolipid and phospholipid metabolism","description":"This cluster is dominated by terms for sphingosine and sphinganine-1-phosphate metabolic processes, phospholipid catabolic and dephosphorylation activities, and phosphatidylglycerol biosynthesis, pointing to lipid metabolism as the core theme. Some non-lipid terms (e.g., transport and migration signaling) appear but do not outweigh the lipid-focused terms.","confidence":"High","size":27,"edges":38,"triangles":22,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0009395","count":6},{"id":"GO:0015760","count":5},{"id":"GO:0035233","count":5},{"id":"GO:0044328","count":5},{"id":"GO:0006655","count":5}]},{"hash":"938366983536851544","title":"Inflammation-Induced Transcription and Apoptosis","description":"This cluster shows enrichment for immune/stress signaling terms such as response to lipopolysaccharide, response to TNF, apoptotic process, and regulation of transcription, pointing to a module where inflammatory cues drive transcriptional programs and cell fate decisions. Some terms (dopamine biosynthetic process, heart rate regulation) appear peripheral or noise. ","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0043046","count":4},{"id":"GO:0034612","count":3},{"id":"GO:0045654","count":3},{"id":"GO:0006355","count":3}]},{"hash":"447109968511789910","title":"Mitotic Cell Division and Regulation","description":"The strongest signals are cell division, the mitotic cell cycle, and the metaphase/anaphase transition, plus K11-linked ubiquitination, all central to mitosis control. Secondary terms include stress responses and reproductive development, but the dominant theme aligns with mitotic processes.","confidence":"High","size":27,"edges":204,"triangles":804,"max_degree":24,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":12},{"id":"GO:0000278","count":10},{"id":"GO:0070979","count":10},{"id":"GO:0071276","count":9},{"id":"GO:0046661","count":8}]},{"hash":"2117542455778109470","title":"Cell signaling and apoptosis regulation","description":"The cluster centers on intracellular signal transduction and regulation of apoptosis (including GPCR signaling, execution phase of apoptosis, and caspase activation) with accompanying development/immune contexts (heart development, B cell homeostasis) and stimulus responses (glucose, nicotine). This suggests a cohesive theme of how signaling pathways govern cell fate decisions across tissues, rather than a single tissue-specific function.","confidence":"Medium","size":27,"edges":103,"triangles":146,"max_degree":24,"top_function":"wound healing","top_go_terms":[{"id":"GO:0007605","count":10},{"id":"GO:0045736","count":8},{"id":"GO:0001782","count":8},{"id":"GO:0007507","count":8},{"id":"GO:0097194","count":8}]},{"hash":"1117543269229833000","title":"Developmental Signaling and Morphogenesis","description":"The cluster is enriched for developmental and morphogenesis-related signaling terms: heart development; positive regulation of canonical Wnt signaling; ephrin receptor signaling; PDGF receptor signaling; dendritic spine morphogenesis; and cell migration. While immune terms like activated T cell proliferation and interleukin-4 production appear, the dominant theme is signaling pathways that drive tissue development, morphogenesis, and related cellular movements, suggesting a cohesive developmental signaling cluster.","confidence":"High","size":27,"edges":89,"triangles":135,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0090263","count":9},{"id":"GO:0006915","count":9},{"id":"GO:0060997","count":9},{"id":"GO:0016477","count":8}]},{"hash":"41376603496278181","title":"Phospholipid Biosynthesis","description":"The top GO terms cluster around biosynthetic processes for phospholipids (phosphatidylglycerol, phosphatidylserine, phosphatidylethanolamine, phosphatidylinositol) and related lipid production and regulation, suggesting a module centered on membrane phospholipid biosynthesis. Some terms like cytokine response and Leydig cell differentiation appear peripheral to the dominant lipid metabolism theme.","confidence":"Medium","size":27,"edges":251,"triangles":1517,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006655","count":5},{"id":"GO:0006663","count":5},{"id":"GO:1905711","count":5},{"id":"GO:0006659","count":5},{"id":"GO:0006646","count":5}]},{"hash":"2083684428422952662","title":"Blood Coagulation and Vascular Development","description":"This cluster is dominated by blood coagulation and fibrinolysis-related terms, with several developmental processes (pancreas, midbrain, post-embryonic development) and immune signaling events (leukocyte tethering/rolling, chemokine regulation) also prominent. Taken together, the proteins appear to participate in coagulation and vascular development pathways, sometimes with regulatory roles in transcription and immune processes, rather than forming a tightly connected interaction network (no edges). Therefore, a name reflecting coagulation coupled with vascular development best captures the shared function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":27},{"id":"GO:0045944","count":26},{"id":"GO:0031017","count":26},{"id":"GO:1903238","count":26},{"id":"GO:0051919","count":26}]},{"hash":"686890195393008634","title":"Lipid and Carbohydrate Metabolic Pathways","description":"The top GO terms point to diverse metabolic activities, notably lipid-related ones (phospholipid dephosphorylation and epoxygenase P450 pathway) alongside carbohydrate biosynthesis (N-acetylglucosamine, glycolate, and N-acetylneuraminate). There is also a hormone-related signal (response to testosterone). Taken together, these suggest a cluster of metabolic pathways with a potential hormone-responsive angle, rather than a single tightly connected function. Medium","confidence":"","size":27,"edges":3,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0097755","count":5},{"id":"GO:0046839","count":5},{"id":"GO:0019373","count":5},{"id":"GO:0046272","count":5},{"id":"GO:0055114","count":5}]},{"hash":"1433907763305014076","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":47,"triangles":20,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034213","count":1},{"id":"GO:0034354","count":1},{"id":"GO:0009399","count":1},{"id":"GO:0006880","count":1},{"id":"GO:0016226","count":1}]},{"hash":"833751354392027863","title":"Flowering time and inflorescence development","description":"The GO terms cluster around flowering and inflorescence formation, including photoperiodism, timing of the vegetative-to-reproductive transition, and flower development, indicating a cohesive plant reproductive-development theme\u2014despite a couple of unrelated terms that may be noise.","confidence":"Medium","size":27,"edges":35,"triangles":8,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":11},{"id":"GO:0042595","count":3},{"id":"GO:0048575","count":1},{"id":"GO:0009908","count":1},{"id":"GO:0010951","count":1}]},{"hash":"1704522708598572428","title":"Kidney development and nephrogenesis","description":"The cluster shows strong enrichment for kidney-related developmental processes (metanephric, mesonephric duct, collecting duct morphogenesis) and related urinary tract and organogenesis terms, including left-right asymmetry and genitalia development, with supportive terms on fluid shear stress and NO biosynthesis in renal contexts. This indicates a renal development theme.","confidence":"High","size":27,"edges":52,"triangles":33,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":6},{"id":"GO:0045429","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0072177","count":5},{"id":"GO:0071498","count":5}]},{"hash":"1997720989550183434","title":"Olfactory and neural signaling","description":"The cluster includes multiple terms tied to smell and pheromone detection (response to pheromone, sensory perception of smell) and to neuronal communication (ionotropic glutamate receptor signaling pathway, social behavior). Additional terms point to neural plasticity (collateral sprouting in absence of injury) and calcium regulation in the ER, supporting a neuronal/olfactory signaling theme. Some terms are broader (transport, endopeptidase regulation, amyloid fibril formation), but the dominant signals align with olfactory/neural function.","confidence":"High","size":27,"edges":22,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":4},{"id":"GO:0007608","count":4},{"id":"GO:0006810","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0010951","count":4}]},{"hash":"1524485695542355354","title":"Receptor-mediated endocytosis and signaling","description":"This cluster is dominated by terms for receptor engagement (virion attachment, receptor internalization), trafficking through endosomes to lysosomes or melanosomes, and signaling pathways such as integrin and VEGF signaling, along with effects on cell motility. The shared theme appears to be receptor-driven endocytic trafficking coupled to signaling that regulates movement and localization, with some eye/pigment-related processes implied by melanosome transport and visual perception terms.","confidence":"Medium","size":27,"edges":351,"triangles":2925,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0046813","count":27},{"id":"GO:2000145","count":27},{"id":"GO:0061462","count":27},{"id":"GO:1901223","count":27},{"id":"GO:0043128","count":27}]},{"hash":"528487591633375457","title":"Hormone and xenobiotic metabolism with immune regulation","description":"The Top Terms span hormone metabolism (androgen, progesterone), various xenobiotic/catabolic processes (camphor, coumarin, vancomycin biosynthesis) and cellular responses to ions (cesium, potassium) alongside immune modulation terms. This suggests a convergence on chemical processing and hormonal signaling that can influence immune pathways, rather than a single dedicated biological process. Therefore the label reflects a broad chemical metabolism/immunity theme rather than a tightly defined function.","confidence":"Medium","size":27,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":27},{"id":"GO:0019383","count":27},{"id":"GO:0010164","count":27},{"id":"GO:0035865","count":27},{"id":"GO:0046226","count":27}]},{"hash":"1175711553073750682","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000462","count":6},{"id":"GO:0000472","count":6},{"id":"GO:0000480","count":6},{"id":"GO:0042254","count":6},{"id":"GO:0051301","count":5}]},{"hash":"1891056514830149666","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":141,"triangles":325,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070935","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0097350","count":18},{"id":"GO:0060020","count":18},{"id":"GO:0033129","count":18}]},{"hash":"2028255956146130112","title":"Embryonic patterning and organ morphogenesis","description":"This cluster centers on GO terms related to early development and tissue formation, including left-right patterning, pancreas and cartilage development, trophoblast differentiation, EMT in heart cushion formation, and broad endocrine system development. These together suggest a cohesive theme of embryonic patterning and organogenesis across multiple lineages, even if an insect-specific term appears among the annotations. ","confidence":"Medium","size":26,"edges":273,"triangles":1636,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"1943091398811596294","title":"Spindle assembly and microtubule organization","description":"The cluster is dominated by GO terms tied to microtubule dynamics and spindle formation, including mitotic spindle assembly, centrosome duplication, spindle assembly in meiosis, and microtubule nucleation and cortical organization. This points to a cohesive role in organizing microtubules during cell division and related processes. Some terms like acrosome assembly or mRNA localization reflect related microtubule-associated functions across contexts, but the core theme remains spindle/microtubule organization.","confidence":"High","size":26,"edges":310,"triangles":2269,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001675","count":4},{"id":"GO:0000278","count":3},{"id":"GO:0051298","count":3},{"id":"GO:0007058","count":3},{"id":"GO:0090307","count":3}]},{"hash":"74634181181778132","title":"Neural development and axon guidance","description":"This cluster is dominated by GO terms related to neural development and nerve pathfinding, including motor neuron axon guidance, neural tube closure, and cell-matrix adhesion, along with transcriptional regulation and general development terms. A few immune/stress response terms appear but do not define the core function. Overall, the proteins seem to group around neuronal development and axon guidance.","confidence":"Medium","size":26,"edges":13,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0008045","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0009636","count":4},{"id":"GO:0006349","count":3}]},{"hash":"932624726076774393","title":"Nuclear Import and RNA Transport","description":"The cluster is dominated by GO terms for mRNA export, nuclear pore assembly, and import of NLS-bearing and ribosomal proteins into the nucleus, plus hnRNP import, indicating a cohesive theme of nucleocytoplasmic transport and RNA handling; other terms touch on related nuclear processes, supporting this focus.","confidence":"High","size":26,"edges":304,"triangles":2306,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0006406","count":5},{"id":"GO:0051292","count":5},{"id":"GO:0060188","count":4},{"id":"GO:0006607","count":4},{"id":"GO:0000060","count":4}]},{"hash":"1795934075297136586","title":"ER stress\u2013driven RNA processing and translation control","description":"The cluster combines signals linked to ER-stress\u2013triggered apoptosis with RNA processing and translation regulation, including mRNA splicing, translation initiation/reinitiation, and protein phosphorylation. This suggests a cohesive module where ER stress not only induces apoptosis but also tunes RNA processing and protein synthesis.","confidence":"Medium","size":26,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070059","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0032298","count":3},{"id":"GO:0051534","count":2},{"id":"GO:0006468","count":2}]},{"hash":"2177609923526165443","title":"Adaptive immune signaling and cell adhesion","description":"The cluster is enriched for adaptive immunity terms (T cell receptor signaling, IL-4 production, B cell affinity maturation) and integrin-mediated signaling (cell adhesion), suggesting a module for lymphocyte activation and trafficking. Some peripheral terms (retinoic acid response, transcytosis) may reflect broader signaling crosstalk but do not override the adaptive immune theme.","confidence":"High","size":26,"edges":167,"triangles":545,"max_degree":23,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007229","count":24},{"id":"GO:0043552","count":23},{"id":"GO:0010863","count":23},{"id":"GO:0060444","count":22},{"id":"GO:0010641","count":22}]},{"hash":"269695729952158236","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":6},{"id":"GO:0015986","count":4},{"id":"GO:1902600","count":3},{"id":"GO:0021762","count":2},{"id":"GO:0042407","count":2}]},{"hash":"2163297048033543678","title":"Developmental signaling and morphogenesis","description":"These proteins cluster around signaling pathways and processes tied to development, morphogenesis, and cell movement. Key GO terms include cell morphogenesis and axonogenesis, bone development, and responses to growth factors, along with multiple signaling cascades (integrin-mediated signaling, B cell receptor signaling, neurotrophin TRK signaling, and GTPase activity regulation). The common theme is signaling-driven cell differentiation, migration, and morphogenesis across diverse lineages, rather than a single narrow function.","confidence":"Medium","size":26,"edges":12,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0031139","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0048011","count":3}]},{"hash":"552792889112917989","title":"Cardiac muscle contraction and sarcomere organization","description":"The cluster is dominated by GO terms tied to cardiac muscle function and sarcomere structure (cardiac muscle contraction, sarcomere organization, and regulation of heart rate by epinephrine), suggesting proteins involved in the contractile apparatus and its regulation. Additional terms indicate cytoskeletal dynamics (microtubule nucleation) and regulatory processes (protein ubiquitination), with a few outliers like spicule insertion and LPS response that may reflect broader or cross-species annotations. Overall, the core theme is cardiac muscle structure and function.","confidence":"High","size":26,"edges":66,"triangles":89,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:1904706","count":7},{"id":"GO:0060048","count":7},{"id":"GO:0034609","count":6},{"id":"GO:0003065","count":6},{"id":"GO:0060298","count":6}]},{"hash":"1819128118542245873","title":"Angiogenesis and inflammatory signaling","description":"The top GO terms emphasize angiogenesis and vascular remodeling (e.g., positive regulation of smooth muscle proliferation) alongside immune and inflammatory processes (defense response to bacterium, chemokine production, hypersensitivity) and signaling cascades (ERK1/2, adenosine receptor). This suggests a module that coordinates blood vessel growth/remodeling with immune/inflammatory signaling, even though some terms are broader (presynaptic organization, kidney development).","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0048661","count":5},{"id":"GO:0090197","count":5},{"id":"GO:0042742","count":4},{"id":"GO:0006508","count":4}]},{"hash":"1178773913295712087","title":"Developmental gene regulation and signaling","description":"The terms cluster around DNA-templated transcription and key signaling pathways (Wnt, GTPase regulation) implicated in development and cell differentiation, including epithelial-to-mesenchymal transition and endothelial migration, plus germ cell development and supportive metabolic/redox processes. This suggests a broad regulatory module linking gene expression to developmental signaling, with metabolism playing a supporting role. Confidence: Medium","confidence":"","size":26,"edges":36,"triangles":7,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0045454","count":2},{"id":"GO:0043535","count":2},{"id":"GO:0007286","count":2},{"id":"GO:1902499","count":2}]},{"hash":"1196721579929203005","title":"Actin Remodeling and Vesicle Trafficking","description":"The top GO terms cluster around cytoskeleton dynamics (filopodium and stress fiber assembly, Rac signaling, cell spreading) and vesicle transport/disassembly (ER-Golgi trafficking, SNARE complex disassembly), with some involvement in cell division. This suggests a coherent module linking actin remodeling to vesicle trafficking and secretion processes.","confidence":"Medium","size":26,"edges":8,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046847","count":7},{"id":"GO:0043552","count":7},{"id":"GO:0051301","count":5},{"id":"GO:0035494","count":5},{"id":"GO:0006888","count":5}]},{"hash":"1326195126070047635","title":"Unknown","description":"The GO terms are highly diverse (dosage compensation, nucleotide biosynthesis, cilium movement, chromatin/histone modification, development, and apoptosis), with no clear shared function or pathway. The cluster appears heterogeneous, with only a single edge, suggesting no cohesive biological theme to label confidently.","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042464","count":1},{"id":"GO:0006228","count":1},{"id":"GO:0006241","count":1},{"id":"GO:0003351","count":1},{"id":"GO:0006348","count":1}]},{"hash":"1671784125242413613","title":"Oocyte Maturation and Cell Cycle Regulation","description":"The top GO terms cluster around cell cycle control and gene expression, notably oocyte maturation, DNA damage/checkpoint signaling in G1, and ubiquitin-dependent protein degradation, suggesting a coherent theme of transcription coupled to proteolysis during cell cycle progression and maturation.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0001556","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000083","count":3},{"id":"GO:0071276","count":3}]},{"hash":"647249753123185676","title":"Proteoglycan Biosynthesis and Cartilage Development","description":"The cluster is dominated by GO terms for proteoglycan biosynthesis and metabolism (heparan, dermatan, chondroitin), indicating a core theme of glycosaminoglycan production, with developmental context suggested by chondrocyte development and ureteric bud formation.","confidence":"High","size":26,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":4},{"id":"GO:0030202","count":4},{"id":"GO:0033037","count":4},{"id":"GO:0015014","count":4},{"id":"GO:0015015","count":4}]},{"hash":"716694614806720494","title":"Embryonic development and tissue morphogenesis","description":"The top GO terms cluster around embryonic patterning and organogenesis across multiple tissues (left/right pattern formation, pancreas development, cartilage morphogenesis, EMT in heart, placental and endocrine development, outflow tract morphogenesis). This points to a cohesive developmental program guiding tissue formation, rather than a single specific pathway.","confidence":"High","size":26,"edges":6,"triangles":1,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"498480101369182083","title":"Neural and sensory organ development","description":"The top GO terms cluster around neural guidance and sensory organ formation, including retinal ganglion axon guidance, sympathetic neuron projection guidance, and retinal layer development, as well as pheromone detection and facial/ear morphogenesis. While a few terms touch other tissues, the dominant theme is development and wiring of nervous and sensory systems.","confidence":"Medium","size":26,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":6},{"id":"GO:0042595","count":2},{"id":"GO:0008363","count":2},{"id":"GO:0060325","count":1},{"id":"GO:1902336","count":1}]},{"hash":"1724771847187524867","title":"LPS-driven innate immunity and lipid regulation","description":"The top GO terms cluster around detection and response to lipopolysaccharide (LPS), including cellular response to LPS, LPS-mediated signaling, and TNF-related regulation, as well as immune processes like apoptotic cell clearance and hemolymph coagulation, which point to an innate immune module. The lipid storage and cholesterol efflux terms suggest a linked metabolic response accompanying immunity. A pheromone detection term appears less central but does not define the core theme. ","confidence":"Medium","size":26,"edges":140,"triangles":329,"max_degree":22,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043695","count":5},{"id":"GO:0043277","count":4},{"id":"GO:0042381","count":3},{"id":"GO:0032497","count":3},{"id":"GO:0051345","count":3}]},{"hash":"1494422541494070476","title":"Egg chorion and eggshell formation","description":"The GO terms are dominated by chorion-related processes, especially egg chorion assembly and vitelline membrane formation involved in chorion-containing eggshell formation, pointing to proteins involved in eggshell construction during development. A metamorphosis term is present but less specific. Confidence: High","confidence":"","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007552","count":1},{"id":"GO:0035071","count":1},{"id":"GO:0007306","count":1},{"id":"GO:0007305","count":1}]},{"hash":"489257831653560053","title":"Immune and endocrine tissue remodeling","description":"The top GO terms cluster around tissue remodeling and signaling: decidualization and bone resorption indicate remodeling; basement membrane disassembly links to ECM changes; bradykinin catabolic process and T cell cytotoxicity reflect immune/inflammatory activity; thyroid hormone response and Wnt-related regulation reflect endocrine and developmental signaling that can drive remodeling. Together these terms suggest a protein cluster involved in coordinating immune, hormonal, and structural changes in tissues.","confidence":"Medium","size":26,"edges":173,"triangles":660,"max_degree":23,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0097067","count":12},{"id":"GO:0001913","count":12},{"id":"GO:0035593","count":12},{"id":"GO:0034769","count":12},{"id":"GO:0050790","count":12}]},{"hash":"1549756968883479648","title":"Neurovascular development and cell migration","description":"The cluster\u2019s top GO terms center on nervous system and vascular development (angiogenesis, endothelial chemotaxis, pyramidal neuron development, nervous system development) along with cell migration and multicellular development, suggesting a cohesive theme of neurovascular differentiation and movement. Some terms like mRNA processing or osteoblast regulation are less core but do not negate the dominant developmental signal. Overall, the proteins seem coordinated around coordinated development of neural and vascular lineages and their migratory behavior.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001028","count":3},{"id":"GO:0021860","count":3},{"id":"GO:0033689","count":3},{"id":"GO:0001525","count":2},{"id":"GO:0007399","count":2}]},{"hash":"1517315890832375944","title":"Angiogenesis and bone formation","description":"The cluster\u2019s top GO terms emphasize vascular development (positive regulation of angiogenesis, aorta development) and skeletal/connective tissue processes (collagen fibril organization, ossification). While immune-related terms appear, the dominant themes point to blood vessel and bone formation, suggesting a developmental program linking vascular and skeletal tissues. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":5},{"id":"GO:0006958","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0010693","count":3}]},{"hash":"2082642232229838573","title":"Steroid hormone and xenobiotic metabolism","description":"The cluster is dominated by GO terms for steroid hormone metabolism (androgen, progesterone, vitamin D) and various xenobiotic/catabolic processes (camphor, coumarin), with additional ion-response terms, suggesting a cohesive role in processing endogenous hormones and foreign compounds; a few immune regulation terms imply potential hormone-immune interactions.","confidence":"High","size":26,"edges":64,"triangles":36,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":26},{"id":"GO:0019383","count":26},{"id":"GO:0010164","count":26},{"id":"GO:0035865","count":26},{"id":"GO:0046226","count":26}]},{"hash":"934103675472190695","title":"Mitotic Chromosome Dynamics & RNA Processing","description":"The terms show a blend of chromosome-centric functions (DNA-templated transcription, CENP-A chromatin assembly, mitotic cell cycle) with microtubule-related processes (microtubule severing) and RNA processing (splicing, transport), suggesting a cohesive theme around chromosome maintenance during mitosis and related RNA handling, plus regulatory signaling (TORC1, GTPase activity) that coordinates these activities.","confidence":"Medium","size":25,"edges":230,"triangles":1083,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0051013","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051028","count":3}]},{"hash":"1348190851715589370","title":"RNA Pol II Transcription Regulation Cluster","description":"The cluster is dominated by GO terms for DNA-templated transcription and transcription by RNA polymerase II, indicating a core focus on gene expression control. Additional terms touch on regulatory processes in development (left/right patterning, vascular wound healing), immune regulation (IgE isotype switching), and cellular stress responses (ER stress, amino acid starvation) along with ubiquitin-dependent protein catabolism, suggesting a broader network where transcriptional control interfaces with development, immunity, and stress signaling.","confidence":"High","size":25,"edges":300,"triangles":2300,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0006366","count":6},{"id":"GO:0035470","count":6},{"id":"GO:0060972","count":5},{"id":"GO:0048294","count":5}]},{"hash":"1768202825760090198","title":"Macromolecular quality control and assembly","description":"The cluster is dominated by proteostasis- and assembly-related GO terms: cellular response to misfolded protein, autophagosome maturation, nonfunctional rRNA decay, and protein retention/processing in the Golgi, plus protein hexamerization and mitochondrial complex III assembly. These indicate a shared theme of maintaining protein and macromolecule quality and proper assembly, often under stress, with some peripheral links to energy metabolism (ATP biosynthesis) and replication-related processes. Confidence: Medium","confidence":"","size":25,"edges":145,"triangles":405,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0071218","count":8},{"id":"GO:0045053","count":8},{"id":"GO:0070651","count":8},{"id":"GO:0030420","count":7}]},{"hash":"884121984712521538","title":"Rab/Rap-regulated vesicle trafficking","description":"The cluster is defined by multiple GO terms tied to Rab and Rap signaling and a range of vesicle transport steps (ER-to-Golgi, plasma membrane to Golgi, endosome trafficking, and vesicle fusion), pointing to a cohesive group of proteins regulating vesicular trafficking and membrane transport. Some terms about cilium assembly and NFAT signaling are ancillary, but the vesicle trafficking theme dominates.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032483","count":3},{"id":"GO:0032486","count":3},{"id":"GO:0031578","count":2},{"id":"GO:1902953","count":2},{"id":"GO:0031338","count":2}]},{"hash":"714084592485801033","title":"Developmental Regulation of Transcription and Signaling","description":"This cluster includes terms tied to multiple developmental processes (heart, brain, gamete development) and neural memory functions, along with regulatory signaling and transcription control (RNA polymerase II regulation, Rho signaling, GPCR pathways). The common thread is broad developmental regulation coupled with signaling rather than a single specific function, so the label reflects both aspects. ","confidence":"Medium","size":25,"edges":54,"triangles":17,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007420","count":3},{"id":"GO:0048477","count":3}]},{"hash":"1032688005072447716","title":"Antiviral innate immune signaling","description":"The cluster is enriched for GO terms tied to dsRNA response, defense against viruses, and interferon production (e.g., response to exogenous dsRNA, defense response to virus, MyD88-independent TLR signaling, and positive regulation of type II interferon production), pointing to a shared role in innate antiviral signaling, despite a few unrelated metabolic terms that may be incidental. ","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043330","count":3},{"id":"GO:0070681","count":2},{"id":"GO:0009062","count":2},{"id":"GO:0019876","count":2},{"id":"GO:0032543","count":2}]},{"hash":"14112466785923981","title":"Ribosome Biogenesis & Translation","description":"This cluster is dominated by GO terms tied to ribosome production and protein synthesis\u2014ribosomal subunit biogenesis and assembly, rRNA maturation (SSU and LSU), and cytoplasmic translation\u2014indicating a cohesive module of ribosome construction and function. Some related terms about cell cycle checkpoints and blastocyst formation may reflect broader regulatory roles, but the core theme centers on translation machinery. ","confidence":"High","size":25,"edges":293,"triangles":2151,"max_degree":24,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0042273","count":6},{"id":"GO:0000027","count":5},{"id":"GO:0042254","count":4},{"id":"GO:0002181","count":4}]},{"hash":"1573870423037419997","title":"Ribosome Biogenesis and Translational Fidelity","description":"This cluster is centered on core ribosome-related processes: translation (cytoplasmic), ribosome biogenesis, and large subunit assembly, with multiple terms addressing translational fidelity and its regulation/maintenance. These together point to a group of proteins involved in ribosome production and ensuring accurate protein synthesis, with occasional peripheral links to antibiotic response that can reflect ribosome-associated stress pathways. ","confidence":"High","size":25,"edges":261,"triangles":1699,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0042254","count":6},{"id":"GO:0000027","count":5},{"id":"GO:0046677","count":4},{"id":"GO:0006407","count":4}]},{"hash":"456283056065700070","title":"Inflammation, Coagulation, and Fibrinolysis","description":"The cluster is dominated by GO terms for acute-phase response, blood coagulation, fibrinolysis, and lipopolysaccharide response, with leukocyte recruitment and angiogenesis also present. Together these suggest a coordinated innate inflammatory program linked to hemostasis and vascular remodeling, even though one term is obsolete and another relates to pancreas development. ","confidence":"High","size":25,"edges":120,"triangles":214,"max_degree":20,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0014068","count":18},{"id":"GO:0006953","count":17},{"id":"GO:0045766","count":17},{"id":"GO:0042730","count":17},{"id":"GO:0007596","count":17}]},{"hash":"629374182047301910","title":"Unknown","description":"Unknown","confidence":"","size":25,"edges":16,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006898","count":5},{"id":"GO:0031214","count":5},{"id":"GO:0030194","count":4},{"id":"GO:0006935","count":4},{"id":"GO:0050427","count":4}]},{"hash":"770386184709082641","title":"Gene Expression Regulation and Cell Cycle","description":"The cluster's top GO terms center on regulating gene expression at multiple levels (translation initiation regulation, nuclear mRNA surveillance) and on cell cycle control, with additional signals for GTPase-mediated signaling and protein folding (peptidyl-prolyl isomerase). Some terms are obsolete, but the remaining pattern points to a cohesive role in coordinating transcriptional/post-transcriptional processes with cell-cycle progression rather than core metabolism.","confidence":"Medium","size":25,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":3},{"id":"GO:0000413","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006446","count":2}]},{"hash":"1103999453766410329","title":"Actin Cytoskeleton Remodeling","description":"This cluster is strongly enriched for GO terms related to actin organization and lamellipodium assembly (e.g., lamellipodium assembly, actin filament organization, actin filament bundle assembly) and includes regulation of Rho signaling, pointing to a core function in actin cytoskeleton dynamics and cell motility. Additional terms touch on signaling pathways (ephrin, PI3K) and related processes, but the primary unifying theme is actin remodeling.","confidence":"High","size":25,"edges":263,"triangles":1608,"max_degree":24,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030032","count":10},{"id":"GO:0007015","count":8},{"id":"GO:0035023","count":8},{"id":"GO:0043552","count":7},{"id":"GO:0006915","count":7}]},{"hash":"1232499195153734786","title":"SNARE-mediated vesicle trafficking and synaptic transmission","description":"These proteins are enriched for ER-to-Golgi transport, SNARE complex assembly, Golgi organization, various vesicle fusion steps, and both presynaptic vesicle fusion and postsynaptic receptor insertion, with a tie to synaptic plasticity (LTP). This points to a cohesive group involved in vesicular trafficking that underpins synaptic signaling.","confidence":"High","size":25,"edges":178,"triangles":805,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":9},{"id":"GO:0035493","count":8},{"id":"GO:0098967","count":8},{"id":"GO:0048280","count":8},{"id":"GO:0090161","count":7}]},{"hash":"1396939743003547676","title":"Hippocampal neuron development and dendrite morphogenesis","description":"The cluster is enriched for nervous system development, hippocampus development, and dendrite morphogenesis, with related regulation of axonogenesis and JNK signaling, suggesting a primary role in neuronal differentiation and dendritic remodeling in the hippocampus. While mitotic cell cycle terms appear, the neuronal development theme is the most coherent across the top GO terms.","confidence":"Medium","size":25,"edges":106,"triangles":180,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":19},{"id":"GO:0007399","count":16},{"id":"GO:0043552","count":16},{"id":"GO:0050771","count":16},{"id":"GO:0046330","count":16}]},{"hash":"1244701359817665723","title":"Pheromone-Linked Lipid Biosynthesis","description":"The cluster is enriched for fatty acid and sphingolipid biosynthesis (long-chain, unsaturated, polyunsaturated) and pheromone metabolism, with GO terms for courtship behavior and swim bladder development, suggesting lipid signaling roles in reproductive contexts. The presence of post-Golgi vesicle transport and multivesicular body sorting implies coordinated trafficking related to secretion of lipid-derived signals, forming a cohesive lipid/metabolism- and pheromone-signaling theme.","confidence":"Medium","size":25,"edges":234,"triangles":1227,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":4},{"id":"GO:0042761","count":4},{"id":"GO:0030148","count":4},{"id":"GO:0006892","count":4},{"id":"GO:0006636","count":4}]},{"hash":"1623925915286955451","title":"Cuticle morphogenesis and collagen fibril organization","description":"The cluster is dominated by GO terms for body morphogenesis, chitin-based cuticle development, and collagen fibril organization, with the collagen-specific hydroxylation step, indicating coordinated cuticle formation and extracellular matrix remodeling. Supplemental terms about iron handling are present but do not define the main function. ","confidence":"High","size":25,"edges":118,"triangles":185,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":6},{"id":"GO:0040003","count":6},{"id":"GO:0030199","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0032504","count":2}]},{"hash":"50924322530267661","title":"Plant Reproductive Development","description":"The presence of pollen maturation and inflorescence development terms suggests a plant-specific focus on reproductive development, while other terms indicate general cellular processes (cell cycle, ubiquitination, autophagy, exocytosis) that are not unique to this cluster; overall, the strongest cohesive signal points to plant reproductive development.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010152","count":1},{"id":"GO:0010229","count":1},{"id":"GO:0061614","count":1},{"id":"GO:0000278","count":1},{"id":"GO:0070979","count":1}]},{"hash":"1578516511107394367","title":"Endocytic Trafficking and Autophagy Regulation","description":"The top GO terms cluster around endomembrane vesicle transport routes: plus-end\u2013directed movement along microtubules, endosome-to-Golgi and plasma membrane-to-endosome trafficking, lysosome localization, and Rab-regulated signaling. The presence of both positive and negative regulation of autophagosome maturation ties these proteins to autophagy control, suggesting a cohesive function in endocytic trafficking with autophagy regulation. A minor association to B cell receptor signaling may reflect immune cell vesicle dynamics but does not dominate the theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072383","count":4},{"id":"GO:1903527","count":4},{"id":"GO:0043553","count":4},{"id":"GO:0050853","count":3},{"id":"GO:1901097","count":3}]},{"hash":"953970588362024083","title":"Unknown","description":"GO terms are scattered with no dominant shared function (most terms appear once) and there are no edges or connectivity to tie the proteins into a single theme; thus no coherent cluster function can be inferred.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006468","count":1},{"id":"GO:0035376","count":1},{"id":"GO:0031274","count":1},{"id":"GO:0034063","count":1},{"id":"GO:1990872","count":1}]},{"hash":"1516923991902592431","title":"Embryonic organ morphogenesis","description":"The GO terms point to developmental processes that shape tissues and organs across multiple systems (pancreas, cartilage, palate, muscle, placenta) and involve patterning and epithelial-to-mesenchymal transitions, all rooted in transcriptional regulation during embryogenesis. This cohesive theme supports a label centered on embryonic organ formation and tissue morphogenesis.","confidence":"High","size":25,"edges":229,"triangles":1150,"max_degree":24,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0003323","count":7},{"id":"GO:0060536","count":7},{"id":"GO:0060707","count":7},{"id":"GO:0003198","count":7}]},{"hash":"1523031482297193087","title":"Embryonic organogenesis and neural development","description":"The GO terms cluster around development of multiple organs and neural/muscular structures (heart, palate, inner ear, skeletal muscle) and processes like neuron migration and motor axon guidance, indicating a broad developmental/morphogenetic theme rather than a single tissue-specific function.","confidence":"High","size":25,"edges":10,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":12},{"id":"GO:0007507","count":10},{"id":"GO:0001759","count":9},{"id":"GO:0007626","count":9},{"id":"GO:0007519","count":9}]},{"hash":"1642740210741271637","title":"Glycosylation biosynthesis and ER-Golgi transport","description":"The cluster is dominated by glycosylation-related GO terms (GPI anchor biosynthesis, dolichol-linked oligosaccharide biosynthesis, N- and O-linked glycosylation) and by ER-to-Golgi vesicle transport, with supportive hints from ERAD and chaperone-related refolding. This points to proteins involved in the secretory pathway and glycoprotein processing rather than a single enzyme, with a plant-specific note from pollen tube guidance that may relate to secretion in pollen. Overall, a cohesive theme around glycosylation and ER-Golgi trafficking.","confidence":"High","size":25,"edges":155,"triangles":504,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":8},{"id":"GO:0006488","count":6},{"id":"GO:0010183","count":5},{"id":"GO:0018279","count":4},{"id":"GO:0070389","count":2}]},{"hash":"1738629156691090415","title":"Angiogenesis and coagulation with inflammation","description":"The top GO terms converge on vascular and immune processes: positive regulation of angiogenesis, fibrinolysis, blood coagulation, acute-phase response, and leukocyte tethering/rolling, indicating a vascular inflammation/coagulation program. There are also transcriptional regulation signals and some developmental terms that may be incidental. Overall, the theme centers on angiogenesis coupled with coagulation and inflammatory responses.","confidence":"High","size":25,"edges":20,"triangles":3,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":17},{"id":"GO:0045766","count":17},{"id":"GO:0042730","count":17},{"id":"GO:0007596","count":17},{"id":"GO:0006953","count":17}]},{"hash":"1754779351964335746","title":"Complement, Coagulation, and Neural Crest Guidance","description":"This cluster shows strong representation of immune/coagulation processes (complement activation, blood coagulation, adaptive immune response) along with neural crest-related development terms (neural crest cell migration, axon guidance, neuron projection extension), suggesting a set of secreted signaling molecules influencing both immune/hemostatic pathways and neural development. ","confidence":"Medium","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0014068","count":10},{"id":"GO:0006958","count":9},{"id":"GO:0007596","count":7},{"id":"GO:0007413","count":7},{"id":"GO:0002250","count":6}]},{"hash":"1705103725127544701","title":"Pole Cell Formation and Cell Cycle Regulation","description":"The top GO terms point to early embryonic development in insects, notably pole cell formation and maternal axis specification, combined with tight regulation of the cell cycle (mitosis/meiosis) and ubiquitin-mediated protein turnover (APC activity, K11-linked ubiquitination). While there is also a term on ecdysteroid biosynthesis, the dominant theme across the cluster is pole plasm\u2013driven embryogenesis linked with cell division control, suggesting a coherent role in early development and cell-cycle regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007279","count":2},{"id":"GO:0007311","count":2},{"id":"GO:0045998","count":2},{"id":"GO:0030071","count":1},{"id":"GO:0031145","count":1}]},{"hash":"1820097581930662260","title":"Embryonic patterning and mesoderm morphogenesis","description":"Most terms point to embryonic development and tissue formation, including left/right patterning, mesoderm development, cartilage morphogenesis, placental and heart-associated differentiation (endocardial cushion EMT, trophoblast giant cell differentiation). A few terms (spliceosome splicing; DNA replication initiation) appear tangential but do not override the primary developmental theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0000398","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4}]},{"hash":"331294273744042249","title":"Iron Transport and Homeostasis","description":"This cluster's strongest signals center on iron handling: iron ion import across the plasma membrane, intracellular iron ion homeostasis, and transferrin transport, with transmembrane transport also present. While a few terms reflect general processes (proteolysis, deglutamylation) or pain response, the iron-related functions are the most coherent theme across the top GO terms, justifying a label focused on iron uptake and maintenance. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035609","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0098707","count":2},{"id":"GO:0006879","count":2},{"id":"GO:0033572","count":2}]},{"hash":"1764280737052758041","title":"Embryonic patterning and organ morphogenesis","description":"The top GO terms consistently point to developmental processes across embryos, including left/right patterning, axis specification, various morphogenesis events (cartilage, pancreatic cells, endocardial cushion EMT), placenta/endocrine system development, and germ cell formation. This suggests a cluster of proteins broadly involved in embryonic patterning and organ formation, making this label appropriate and representative.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":12},{"id":"GO:0003323","count":12},{"id":"GO:0060536","count":12},{"id":"GO:0060707","count":12},{"id":"GO:0003198","count":12}]},{"hash":"2261666241313327042","title":"Neuronal axon guidance and migration","description":"The top GO terms indicate a clear focus on neural development, especially axon guidance for dopaminergic and serotonergic neurons and neuron migration. While terms like planar polarity, heart trabecula formation, and body hair orientation reflect broader embryogenesis, the strongest signals are neural pathfinding and migration, with electron transport and stress response providing supporting context for neuronal function. Overall, the cluster coherently represents neuronal development and axon guidance. ","confidence":"High","size":25,"edges":170,"triangles":586,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0008340","count":11},{"id":"GO:0007166","count":11},{"id":"GO:0006950","count":11},{"id":"GO:0022900","count":8},{"id":"GO:0036514","count":8}]},{"hash":"378354266080537318","title":"Rho-GTPase\u2013regulated actin cytoskeleton dynamics","description":"The dominant GO terms indicate regulation of Rho signaling and GTPase activity, actin filament turnover, and actin cytoskeleton organization, with notes on endocytosis and muscle-related processes that depend on cytoskeletal remodeling. This suggests a function cluster centered on actin dynamics governed by Rho/GTPase pathways.","confidence":"High","size":24,"edges":32,"triangles":17,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0030042","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0048549","count":4},{"id":"GO:0031532","count":4}]},{"hash":"1638763404958587972","title":"Innate Immune Response","description":"The cluster is enriched for innate immunity terms, with defense response to virus and innate immune response appearing most frequently (3 each), suggesting a core role in antiviral defense. Other terms like development or metabolic processes are present but less prominent, implying these proteins may have additional annotations or multifunctionality, while the dominant signal points to innate immune function.","confidence":"Medium","size":24,"edges":11,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051607","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0005978","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0032092","count":2}]},{"hash":"1930273159185959993","title":"Bacterial ion and metabolite transporters","description":"The cluster is dominated by transmembrane transport GO terms for a variety of substrates (succinate, malate, citrate, arsenite, monoatomic anions, Na+, K+, phosphate), indicating a cohesive group of membrane transport proteins handling ions and small metabolites. The presence of one related biosynthetic term (enterobacterial common antigen biosynthesis) aligns with bacterial envelope-associated processes, but the core signal is transport across membranes. This makes the label a specific, representative summary of the cluster\u2019s function.","confidence":"High","size":24,"edges":64,"triangles":101,"max_degree":14,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0009246","count":18},{"id":"GO:0015744","count":3},{"id":"GO:0015743","count":3},{"id":"GO:0006813","count":3},{"id":"GO:2000185","count":3}]},{"hash":"43012875714529989","title":"Skeletal muscle calcium handling","description":"The top GO terms converge on calcium signaling and homeostasis in muscle, notably negative regulation of cytosolic Ca2+ concentration, intracellular Ca2+ homeostasis, skeletal muscle relaxation, and T-tubule organization, which are all central to excitation-contraction coupling. Additional terms about cation transport (including zinc) and ion signaling support a broader ion-transport context but do not override the muscle calcium focus. Overall, the cluster seems to represent proteins involved in calcium control within skeletal muscle cells.","confidence":"High","size":24,"edges":9,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051481","count":3},{"id":"GO:0090076","count":3},{"id":"GO:0051208","count":3},{"id":"GO:0099132","count":3},{"id":"GO:0033292","count":3}]},{"hash":"2190824316236140920","title":"Bacterial sugar catabolism and quorum sensing","description":"The top GO terms cluster around diverse sugar catabolic pathways (L-arabinose, D-xylose, rhamnose, L-fucose, D-glucuronate, xylulose) and related carbohydrate metabolism, plus glycerol-3-phosphate biosynthesis and carbohydrate phosphorylation, with quorum sensing linking metabolic and signaling processes.","confidence":"Medium","size":24,"edges":223,"triangles":1185,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":10},{"id":"GO:0019569","count":6},{"id":"GO:0005998","count":6},{"id":"GO:0019301","count":6},{"id":"GO:0009372","count":6}]},{"hash":"1115861947348163918","title":"Purine Nucleotide Salvage","description":"This cluster is dominated by GO terms for salvage and catabolic pathways of nucleotides and purines (e.g., purine ribonucleoside salvage, inosine/uridine catabolism, deoxyguanosine catabolism) and related NAD and methionine salvage pathways. The common theme is maintenance and recycling of nucleotide/nucleoside pools rather than de novo synthesis, suggesting a functional grouping around nucleotide salvage metabolism.","confidence":"High","size":24,"edges":26,"triangles":14,"max_degree":8,"top_function":"protein maturation","top_go_terms":[{"id":"GO:0019509","count":7},{"id":"GO:0019284","count":7},{"id":"GO:0019358","count":7},{"id":"GO:0034356","count":7},{"id":"GO:0006161","count":6}]},{"hash":"116420868829540928","title":"Cell signaling and developmental regulation","description":"It shows widespread regulatory activity across signaling cascades (GTPase/Rho and ERK) and development, plus cell-type specific regulatory processes (NK cell differentiation, insulin secretion, IL-5 production, fibroblast proliferation, progesterone biosynthesis), indicating a broad regulatory theme rather than a single pathway.","confidence":"Medium","size":24,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0060211","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0048147","count":2}]},{"hash":"2300700747857973160","title":"Organelle proteostasis and quality control","description":"The top GO terms cluster around proteostasis and organelle maintenance: ubiquitin-dependent ERAD, autophagosome maturation, late endosomal microautophagy, and peroxisomal protein import, plus mitochondrial complex III assembly and protein hexamerization. Together these suggest a shared theme of protein quality control and organelle biogenesis/maintenance across cellular compartments, despite some outliers and obsolete terms. ","confidence":"Medium","size":24,"edges":8,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0016558","count":4},{"id":"GO:0030420","count":3},{"id":"GO:2001171","count":3},{"id":"GO:0097352","count":3}]},{"hash":"1499821605989175682","title":"Neuronal signaling and proteostasis regulation","description":"This cluster combines neuronal functions (visual perception; dopaminergic synaptic transmission) with gene expression and protein turnover processes (transcription by RNA polymerase II; proteasome-mediated degradation; ubiquitin-related endocytosis). The co-occurrence of GTPase activity regulation and ubiquitin pathways suggests coupling of signaling dynamics with protein trafficking and turnover, pointing to a neuronal signaling module tied to transcriptional control and proteostasis.","confidence":"Medium","size":24,"edges":64,"triangles":56,"max_degree":19,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":11},{"id":"GO:0070086","count":11},{"id":"GO:0006366","count":10},{"id":"GO:0031397","count":10},{"id":"GO:0007601","count":10}]},{"hash":"1759505059610708558","title":"Ciliogenesis and Spindle Regulation","description":"The top GO terms cluster around assembly and movement of cilia/axonemes (axomene/motile cilium assembly, cilium movement) and mitotic spindle processes (mitotic spindle assembly, regulation of spindle organization), with supporting hints from Wnt signaling and calcium release, suggesting a module tied to microtubule-based organelle formation and cell division coordination. This combination points to a cohesive ciliogenesis\u2013spindle regulation theme rather than disparate processes.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":2},{"id":"GO:0048549","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0035082","count":1},{"id":"GO:0044458","count":1}]},{"hash":"1674213115890871945","title":"Amino acid and related transmembrane transport","description":"Top GO terms indicate import/transport of various amino acids across plasma membrane (L-arginine, L-lysine, L-ornithine, D-alanine, D-serine, etc.), plus related transmembrane transport of polyamines and carnitine and transepithelial ammonium transport. This pattern points to a cohesive function group of amino acid transporters and associated metabolite transporters. The inflammatory nitric oxide production term likely reflects downstream arginine metabolism, but the central theme is membrane transport of amino acids and related substrates.","confidence":"High","size":24,"edges":31,"triangles":15,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097638","count":7},{"id":"GO:0042941","count":7},{"id":"GO:0042942","count":7},{"id":"GO:0070634","count":7},{"id":"GO:0097639","count":7}]},{"hash":"350375392865795682","title":"Immune Activation and Inflammation","description":"Most of the prominent GO terms describe innate immune responses and inflammatory processes, including complement activation (lectin pathway), leukocyte adhesion/trafficking (tethering/rolling), phagocytosis recognition, and regulation of NK cell chemotaxis, as well as platelet activation and responses to fungal molecules. Together these suggest an inflammatory/immune module. Some developmental terms (cartilage condensation, mesonephric duct development) are less cohesive with the rest and may reflect broader signaling overlaps, but the dominant signal points to immune/inflammatory functions.","confidence":"Medium","size":24,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":15},{"id":"GO:0071226","count":15},{"id":"GO:0090238","count":15},{"id":"GO:0050901","count":15},{"id":"GO:0072177","count":15}]},{"hash":"1959243002807613692","title":"Neuronal development and synaptic function","description":"The terms cluster around neuronal signaling, neurotransmitter handling, and cerebellar neuron development (synaptic vesicle exocytosis, neurotransmitter secretion/transport, synaptic plasticity, Purkinje cell differentiation, and neuron migration). Although there are a couple of outliers (histone acetylation, insulin secretion, thyroid hormone response), the dominant theme is nervous system development and synaptic function, suggesting proteins in this cluster participate in neuronal maturation and communication.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016573","count":1},{"id":"GO:0030073","count":1},{"id":"GO:0031915","count":1},{"id":"GO:0016079","count":1},{"id":"GO:0046928","count":1}]},{"hash":"1876058755606732520","title":"Organogenesis and Morphogenesis","description":"The top GO terms cluster around developmental processes across several organs, including palate development, heart looping, skeletal muscle differentiation, and CNS formation, suggesting a shared theme of organogenesis and morphogenesis. Some terms relate to transcription/chromatin regulation, which can participate in developmental control, but the dominant signal is multi-tissue development. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060021","count":2},{"id":"GO:2000219","count":1},{"id":"GO:0016479","count":1},{"id":"GO:0061186","count":1},{"id":"GO:0061408","count":1}]},{"hash":"960162737513059739","title":"Unknown","description":"The top GO terms include pheromone detection and smell, but also immune and metabolic processes, with no clear, single cohesive function linking them all. This makes a concise, representative label difficult. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":6},{"id":"GO:0042595","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0014068","count":2},{"id":"GO:0090197","count":2}]},{"hash":"225606882511935646","title":"Developmental Gene Regulation","description":"The cluster\u2019s top GO terms predominantly point to development (midbrain and exocrine pancreas development, post-embryonic development) along with regulation of transcription by RNA polymerase II, suggesting proteins that coordinately control developmental programs via transcriptional control. Immune and metabolic terms appear as secondary regulatory connections, but the core signal is developmental gene regulation.","confidence":"Medium","size":24,"edges":13,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032504","count":4},{"id":"GO:0045944","count":1},{"id":"GO:0031017","count":1},{"id":"GO:1903238","count":1},{"id":"GO:0051919","count":1}]},{"hash":"1518620328522363897","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning pheromone detection, insect cuticle development, cold acclimation, immune regulation, synaptic organization, and various developmental pathways. There is no single, cohesive theme that ties these proteins together, so a specific functional label isn\u2019t supported.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":4},{"id":"GO:0008363","count":1},{"id":"GO:0009631","count":1},{"id":"GO:0001812","count":1},{"id":"GO:0097090","count":1}]},{"hash":"2246355285802237443","title":"BMP signaling in development and bone formation","description":"The top terms cluster around BMP signaling and bone-related processes (BMP signaling pathway, negative/positive regulation of BMP signaling, ossification, osteoblast differentiation), indicating a core theme of BMP-mediated development and skeletal formation, with supporting developmental processes like forebrain development and morphogenesis that can be BMP-regulated.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045668","count":3},{"id":"GO:0030514","count":3},{"id":"GO:0030509","count":2},{"id":"GO:0001503","count":2},{"id":"GO:0007378","count":2}]},{"hash":"352547902909195704","title":"Nuclear RNA processing and chromatin regulation","description":"The GO terms cluster around nuclear processes: chromatin-related activities (sperm DNA condensation, X chromosome inactivation, V(D)J recombination) alongside RNA processing and translation-related functions (splicing, tRNA processing, translation, and mitochondrial tRNA aminoacylation). This points to a theme of nuclear gene expression control integrating chromatin dynamics with RNA maturation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035092","count":2},{"id":"GO:0035093","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0070156","count":1}]},{"hash":"289858033015599624","title":"Embryonic organ morphogenesis and neural guidance","description":"The terms cluster around developmental processes across multiple organs (heart valve and endocardial cushion formation; lung morphogenesis and branching; dopaminergic and serotonergic axon guidance) and include a general cell adhesion term, suggesting a shared theme of embryonic tissue morphogenesis and neural pathfinding. Some terms are less related (obsolete oxidation-reduction, pheromone detection, B cell differentiation), but the dominant signal is developmental organization and guidance. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0043695","count":2},{"id":"GO:0003192","count":2},{"id":"GO:0003273","count":2},{"id":"GO:0060490","count":2}]},{"hash":"660719476624611260","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0030420","count":1},{"id":"GO:1990180","count":1},{"id":"GO:1903999","count":1}]},{"hash":"1303551172849271778","title":"Membrane Transporters for Ions and Metabolites","description":"The top GO terms point to broad transmembrane transport activities across ions (e.g., sodium), nitrates/nitrites, sugars (galactose, fucose), vitamins, and xenobiotics, plus neurotransmitter loading into synaptic vesicles, implying a cohesive cluster of transporter proteins or transporter-associated components.","confidence":"High","size":24,"edges":72,"triangles":124,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":10},{"id":"GO:0042128","count":10},{"id":"GO:0006004","count":10},{"id":"GO:0015707","count":10},{"id":"GO:0035725","count":10}]},{"hash":"1996094771041165956","title":"Insect olfaction and pheromone signaling","description":"The top GO terms center on detection and perception of chemical cues, including pheromone detection, olfactory and courtship-related behaviors, and smell perception, with additional responses to chemical stimuli like CO2 and various compounds. This points to a cohesive theme of insect olfactory sensing and pheromone-mediated behavior.","confidence":"High","size":24,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":7},{"id":"GO:0007619","count":6},{"id":"GO:0042048","count":6},{"id":"GO:0050911","count":6},{"id":"GO:0007608","count":6}]},{"hash":"1979517990883559480","title":"Neural development and axon guidance","description":"These terms cluster around neural development and neurite outgrowth: midbrain dopaminergic neuron differentiation, motor neuron axon guidance, lamellipodium assembly, cell migration, and cell-matrix adhesion reflect neuronal morphogenesis and pathfinding. Growth hormone receptor and insulin receptor signaling terms suggest broader regulatory cues but do not contradict the neural-development theme. Overall, the cluster coherently points to neural differentiation and axon guidance.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":6},{"id":"GO:0016477","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0008045","count":4},{"id":"GO:0090334","count":4}]},{"hash":"305167776383492096","title":"Melanosome transport and paranodal junctions","description":"The top GO terms point to vesicle trafficking to lysosomes and melanosomes (protein localization to lysosome; endosome to melanosome transport) and to paranodal junction assembly, suggesting a theme of vesicle transport and neural/pigment-cell junctions. Additional signaling terms (integrin and VEGF) plus visual perception reinforce a retina/pigment-cell context. Together these indicate a cohesive function around vesicle trafficking linked to neural/paranodal junctions and pigment cell biology, hence the label. ","confidence":"Medium","size":24,"edges":28,"triangles":18,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":10},{"id":"GO:0046813","count":9},{"id":"GO:2000145","count":9},{"id":"GO:0061462","count":9},{"id":"GO:1901223","count":9}]},{"hash":"1678060166079111657","title":"Vacuolar amino acid transporters","description":"Most top GO terms point to transmembrane transport of specific amino acids into or out of vacuoles (tyrosine, glutamate, arginine, alanine, serine, proline). While there are also developmental terms (cell adhesion, glomerular basement membrane development, EMT), the repeated amino acid transport into vacuoles dominates the functional signal, suggesting a transporter-focused cluster rather than purely developmental modules.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0003323","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0032836","count":3},{"id":"GO:0090514","count":3}]},{"hash":"2270889868120872416","title":"MAPK and PI3K signaling regulators","description":"These proteins cluster around regulation of MAPK (ERK1/ERK2) signaling and phosphatidylinositol-mediated pathways, with additional notes on GTPase activity regulation and stress-related signaling (e.g., cardiac hypertrophy) and differentiation processes. The common theme is modulation of central signaling cascades (MAPK/PI3K) that coordinate growth, differentiation, and vesicle dynamics, justifying a single signaling-regulator label. ","confidence":"Medium","size":24,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0002318","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0014898","count":2},{"id":"GO:0070374","count":2}]},{"hash":"108628166917545186","title":"Neurodevelopment and organogenesis","description":"The cluster shows a strong emphasis on nervous system development (CNS/PNS, neuron migration) along with other developmental processes such as kidney development, angiogenesis, ossification, and cell adhesion, all pointing to broad developmental signaling and morphogenesis across tissues, with neural development being particularly prominent. Confidence reflects a cohesive developmental theme, but the multi-tissue terms prevent a single highly specific function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0045765","count":5},{"id":"GO:0007156","count":5},{"id":"GO:0070374","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1916937669172505531","title":"Sensory Development and Cardiac Stress Signaling","description":"This cluster combines GO terms pointing to sensory and epidermal development (thermosensory behavior, sensory perception of pain, skin development, multicellular organism development, calcium-dependent cell-matrix adhesion) with cardiac-related signaling and stress responses (AV node action potential, positive regulation of cardiac muscle hypertrophy in response to stress, osmotic stress\u2013linked apoptotic signaling), suggesting a theme of developmental/sensory processes linked to cardiac stress signaling rather than a single cohesive function. ","confidence":"Medium","size":24,"edges":6,"triangles":1,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016340","count":9},{"id":"GO:0071805","count":8},{"id":"GO:0040040","count":8},{"id":"GO:0007275","count":7},{"id":"GO:0019233","count":7}]},{"hash":"1765710549684897726","title":"Transmembrane Solute Transporters","description":"The top GO terms are all about transporting various solutes across membranes (nitrate, potassium, phosphate, arabinose, xenobiotic, nitrite, vitamin, etc.), indicating a cluster of membrane transporter proteins with broad substrate scope. This suggests the proteins function collectively as solute transporters rather than a single specific substrate pathway.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":23},{"id":"GO:0071805","count":23},{"id":"GO:0035435","count":23},{"id":"GO:0015751","count":23},{"id":"GO:0006855","count":23}]},{"hash":"1795450978971091405","title":"Hormone-Driven Mammary Development","description":"This cluster is dominated by GO terms tied to mammary gland development and hormone metabolism (androgen and progesterone) plus responses to vitamin D, inflammation regulation, and some xenobiotic/ion response terms, suggesting a cohesive set of proteins involved in endocrine signaling and developmental processes in mammary tissue, with ancillary detoxification-related activities.","confidence":"Medium","size":24,"edges":48,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030879","count":12},{"id":"GO:0008209","count":10},{"id":"GO:0019383","count":10},{"id":"GO:0010164","count":10},{"id":"GO:0035865","count":10}]},{"hash":"2002016833078285516","title":"Insect chemosensation and pheromone detection","description":"This cluster's top GO terms center on sensory perception and chemical cue detection in insects, including carbon dioxide detection, bitter taste, chemosensory behavior, and responses to various chemical stimuli, plus male courtship behavior tied to pheromone sensing. The terms collectively point to a chemosensory/detection-focused group with pheromone-related behavior.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003031","count":4},{"id":"GO:0031000","count":4},{"id":"GO:0017085","count":4},{"id":"GO:1901354","count":4},{"id":"GO:0050913","count":4}]},{"hash":"1188978068143875168","title":"Unknown","description":"The Top Terms are a mix of immune/LPS response terms (detection and signaling, TNF production), metabolic/development terms (pancreas development, insulin secretion, lipid storage, cholesterol efflux), and sensory terms (detection of pheromone), with no clear, cohesive function linking all proteins or edges connecting them. This suggests no single representative function for the cluster.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0031016","count":1},{"id":"GO:0035773","count":1},{"id":"GO:0032497","count":1},{"id":"GO:0051345","count":1}]},{"hash":"95204530607832281","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":249,"triangles":1690,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0042273","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0000466","count":3}]},{"hash":"1976768779086344334","title":"Telomere maintenance and genome stability","description":"The terms point to telomere protection and loop formation, rDNA heterochromatin formation, replication-born double-strand break repair, and chromatin regulation, all of which support genome integrity and chromatin state maintenance. A few terms related to development or immune processes may be annotation artifacts or reflect broad gene functions.","confidence":"Medium","size":23,"edges":97,"triangles":184,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0030183","count":2},{"id":"GO:0009736","count":2},{"id":"GO:0000183","count":2},{"id":"GO:1990414","count":2},{"id":"GO:0035066","count":2}]},{"hash":"1759831378360143790","title":"RNA silencing and miRNA processing","description":"The cluster is enriched with terms tied to RNA interference and miRNA pathways (global gene silencing by mRNA cleavage, regulation of miRNA metabolism, pre-miRNA processing, RISC assembly) along with broader RNA processing activities (tRNA and rRNA processing) and RNA editing, pointing to a core set of proteins involved in RNA silencing and miRNA maturation rather than unrelated processes.","confidence":"High","size":23,"edges":90,"triangles":166,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030423","count":8},{"id":"GO:0008033","count":8},{"id":"GO:2000628","count":7},{"id":"GO:0016075","count":7},{"id":"GO:0050689","count":7}]},{"hash":"1329798654331704272","title":"Endomembrane vesicle trafficking and exocytosis","description":"The top GO terms indicate transport among ER, Golgi, endosomes, lysosomes, and vacuoles, plus vesicle docking and calcium-dependent exocytosis, with GTPase regulation. This pattern defines a coherent vesicle trafficking and secretory pathway module.","confidence":"High","size":23,"edges":135,"triangles":405,"max_degree":19,"top_function":"protein localization to plasma membrane","top_go_terms":[{"id":"GO:0006623","count":6},{"id":"GO:0008333","count":5},{"id":"GO:0006895","count":5},{"id":"GO:0045956","count":5},{"id":"GO:0006888","count":4}]},{"hash":"514195078425748032","title":"Methionine/SAM Metabolism and Pol II Transcription Regulation","description":"Top GO terms reveal a convergence of one-carbon/SAM metabolism with RNA Polymerase II\u2013driven transcription initiation/regulation, plus links to cell cycle and muscle differentiation, suggesting a module where metabolic state influences transcriptional control. This justifies a label that combines methionine/SAM pathways with Pol II transcription regulation.","confidence":"Medium","size":23,"edges":145,"triangles":434,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006730","count":3},{"id":"GO:0006556","count":3},{"id":"GO:0009087","count":3},{"id":"GO:0006367","count":3},{"id":"GO:0042219","count":2}]},{"hash":"1512466190286560566","title":"Transcription and RNA Processing During Cell Cycle","description":"Top GO terms point to nuclear processes: DNA-templated transcription, mRNA splicing, and rRNA maturation, together with cell-cycle activities such as division and chromosome segregation. Additional terms for cilium assembly and TORC1 signaling suggest broader coordination with cytoskeletal dynamics and growth signaling. Overall, the cluster seems to reflect core gene expression machinery and ribosome biogenesis operating in the context of cell-cycle progression.","confidence":"Medium","size":23,"edges":96,"triangles":130,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0021510","count":4},{"id":"GO:0045143","count":4},{"id":"GO:0060271","count":4}]},{"hash":"1413683077690523657","title":"Muscle development and insulin signaling","description":"The top GO terms point to metabolic signaling and muscle formation processes, especially insulin receptor signaling (GO:0008286), myotube differentiation (GO:0014902), and response to muscle stretch (GO:0035994), all of which tie together growth, differentiation, and metabolic regulation in muscle tissue. Additional terms about multicellular development and transcription support a broader developmental context, with some endocrine-related terms (thyroid gland development) suggesting wider hormonal regulation. Overall, the most coherent theme is signaling that coordinates metabolic control with muscle growth and development.","confidence":"Medium","size":23,"edges":38,"triangles":19,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008286","count":8},{"id":"GO:0007095","count":7},{"id":"GO:0014902","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0006351","count":6}]},{"hash":"239153831400125075","title":"Starch and alpha-glucan metabolism","description":"The proteins are enriched for starch biosynthesis and degradation, alpha-glucan (glycogen-like) metabolism, and related sugar pathways (amylopectin, maltose, trehalose, sucrose), indicating a cohesive cluster of enzymes governing starch and related glucan turnover.","confidence":"High","size":23,"edges":129,"triangles":370,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0019252","count":8},{"id":"GO:0030979","count":8},{"id":"GO:0005985","count":8},{"id":"GO:0005980","count":8},{"id":"GO:0051692","count":8}]},{"hash":"1672394039112836770","title":"Endothelial adhesion and angiogenesis","description":"Based on the dominant GO terms, the cluster centers on vascular biology, with emphasis on cell adhesion, endothelial migration, collagen/fibril organization, and angiogenesis regulation. While there are a few outliers (melanocyte-related and host-symbiont processes, plus a cellulose catabolic term), the core signals point to endothelial cell interactions and blood vessel formation, suggesting a cohesive theme around vascular adhesion and angiogenesis.","confidence":"Medium","size":23,"edges":9,"triangles":5,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":5},{"id":"GO:0045766","count":4},{"id":"GO:0030199","count":4},{"id":"GO:1902362","count":3},{"id":"GO:0043542","count":3}]},{"hash":"1830693968691300393","title":"Ubiquitin-dependent proteolysis and NF-\u03baB signaling","description":"This cluster is dominated by GO terms for ubiquitination across several linkages (K48, K63, K11, K6), ubiquitin-dependent proteasomal degradation, and ERAD, pointing to ubiquitin-driven protein turnover. NF-\u03baB related regulation terms appear as a secondary theme, and a peroxisomal matrix protein import term is present but less central. Overall, the cluster centers on ubiquitin-mediated proteolysis with related signaling.","confidence":"High","size":23,"edges":121,"triangles":396,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070936","count":11},{"id":"GO:0051865","count":11},{"id":"GO:0042787","count":11},{"id":"GO:0030433","count":11},{"id":"GO:0043123","count":10}]},{"hash":"503038726012033836","title":"Embryonic organ and tissue development","description":"The top GO terms span palate, skeletal muscle, cranial skeleton morphogenesis, neuron guidance, inner ear, forebrain, heart, thyroid, and visual development, plus multicellular organism development. This pattern points to a broad embryonic developmental program active across multiple organs rather than a single tissue-specific function, so the label reflects a general organogenesis theme.","confidence":"High","size":23,"edges":45,"triangles":24,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":9},{"id":"GO:0007519","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0008045","count":7},{"id":"GO:0048839","count":7}]},{"hash":"1740735105049473203","title":"RNA processing and ribosome biogenesis","description":"The top GO terms are dominated by RNA modification and ribosome-related processes (pseudouridine synthesis in snRNA/rRNA, tRNA modification, translation initiation/reinitiation, ribosome disassembly, and translation-related steps), pointing to a cluster of proteins involved in RNA maturation and ribosome assembly/function. A few other terms (TNF signaling, cell cycle) are present but far less representative, so the overall theme centers on RNA processing and ribosome biology.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":2},{"id":"GO:0001731","count":1},{"id":"GO:0002188","count":1},{"id":"GO:0031120","count":1},{"id":"GO:0007049","count":1}]},{"hash":"1847486477044277231","title":"DNA-Templated Transcription Regulation","description":"Most terms point to transcription initiation and regulation (DNA-templated transcription, regulation of transcription, and positive regulation of transcription by RNA polymerase II). A few other terms (antibiotic/bi Biosynthetic processes, developmental terms) appear incidental rather than indicating a single cohesive pathway. The dominant theme is transcription control, so the label reflects the core function of the cluster.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0045944","count":2},{"id":"GO:1901766","count":2},{"id":"GO:0031342","count":2}]},{"hash":"56795641348074934","title":"Cholinergic synapse proteins","description":"The cluster is dominated by GO terms for cholinergic synaptic transmission and its regulation, along with supporting membrane localization and PI signaling, pointing to components of cholinergic synapses. A few outlier terms related to development and other signaling pathways are present but do not override the core neural signaling theme.","confidence":"High","size":23,"edges":127,"triangles":374,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":9},{"id":"GO:0022417","count":9},{"id":"GO:0032224","count":9},{"id":"GO:0007271","count":9},{"id":"GO:0008363","count":8}]},{"hash":"175547003831770560","title":"Retroviral replication and proviral latency","description":"This cluster centers on the retroviral life cycle and proviral latency, with GO terms for viral release, viral life cycle, RNA-templated DNA biosynthetic process, host-driven activation of viral genome replication, and establishment of integrated proviral latency. A few terms related to protein folding and isomerization appear, likely reflecting host chaperone involvement during viral replication. Overall, the dominant theme is the interaction between host cells and retroviruses, covering replication, integration, and latency maintenance.","confidence":"High","size":23,"edges":5,"triangles":1,"max_degree":3,"top_function":"protein folding","top_go_terms":[{"id":"GO:2000276","count":3},{"id":"GO:0006457","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0019076","count":3},{"id":"GO:0019058","count":3}]},{"hash":"1255708916575409536","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015938","count":1},{"id":"GO:0006382","count":1},{"id":"GO:0046057","count":1},{"id":"GO:1901909","count":1},{"id":"GO:1901911","count":1}]},{"hash":"2219405851726319438","title":"Circadian and xenobiotic stress response genes","description":"The cluster is enriched for transcription by RNA polymerase II, circadian regulation of gene expression, and responses to xenobiotic stimuli and oxidative stress, indicating a set of genes involved in clock-controlled transcription and stress/drug response. Some development and hormonal signaling terms appear, but they likely reflect broader regulatory roles rather than a single pathway. Overall, the common theme is transcriptional control in circadian and stress/endocrine contexts.","confidence":"Medium","size":23,"edges":156,"triangles":576,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":19},{"id":"GO:0090403","count":17},{"id":"GO:2000074","count":17},{"id":"GO:2000323","count":17},{"id":"GO:2001038","count":17}]},{"hash":"1689147220823510273","title":"Heart and nervous system development","description":"The cluster shows strong enrichment for heart development, atrioventricular node development, brain and neural crest formation, and peripheral nervous system neuron development, indicating coordinated cardiovascular and neural ontogeny. Additional terms like visual perception also relate to sensory-neural development, but the core theme is heart and nervous system development.","confidence":"High","size":23,"edges":17,"triangles":1,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":20},{"id":"GO:0007601","count":19},{"id":"GO:0014029","count":18},{"id":"GO:0007275","count":15},{"id":"GO:0007420","count":13}]},{"hash":"624678845363103597","title":"Adipose lipid metabolism and innate immune signaling","description":"The cluster combines lipid handling and adipose tissue functions (cholesterol homeostasis, fatty acid import, oxidation regulation, brown fat differentiation) with immune/stress responses (cellular response to LPS, response to virus) and hormonal signaling (response to insulin). This points to adipose tissue\u2013driven lipid metabolism linked to innate immune sensing and metabolic signaling, justifying a label that emphasizes both lipid processing and immune-related functions.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":4},{"id":"GO:0071222","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0009615","count":2},{"id":"GO:0050873","count":2}]},{"hash":"774612711341895861","title":"Embryonic Patterning and Morphogenesis","description":"The top GO terms indicate pattern formation and tissue morphogenesis across multiple developmental lineages, including left/right axis patterning, cartilage morphogenesis, endocrine system development, and placental/trophoblast differentiation, with EMT-related processes in heart development. Also, regulatory terms for transcription and RNA processing suggest gene-expression control during development, supporting a cohesive theme of embryonic organogenesis and lineage specification.","confidence":"High","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":9},{"id":"GO:0003323","count":9},{"id":"GO:0060536","count":9},{"id":"GO:0060707","count":9},{"id":"GO:0003198","count":9}]},{"hash":"1764881040330740027","title":"Vesicle trafficking and membrane transport","description":"This cluster shows multiple GO terms tied to the secretory pathway and membrane transport, including protein transmembrane transport, Golgi-to-ER retrograde transport, vacuolar acidification, and proton translocation, plus a cell-wall biosynthetic process linked to the secretory route. While a couple terms pertain to nuclear processes (RNA polymerase I transcription, nucleotide-excision repair), the preponderance of trafficking and membrane-related terms suggests a coherence around vesicle movement and organelle membrane homeostasis.","confidence":"Medium","size":23,"edges":18,"triangles":4,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":2},{"id":"GO:0006360","count":2},{"id":"GO:0070816","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0016049","count":1}]},{"hash":"752195717256000410","title":"Larval chitin-based cuticle development","description":"The cluster is strongly enriched for GO:0008363 (larval chitin-based cuticle development) with 22 proteins, suggesting a cohesive function in insect cuticle formation. The remaining terms occur at very low frequency and do not define a unifying function as clearly, but do not outweigh the dominant cuticle-related signal. This makes the label a good representation of the cluster\u2019s core biology.","confidence":"High","size":23,"edges":145,"triangles":438,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":22},{"id":"GO:0034394","count":1},{"id":"GO:0043116","count":1},{"id":"GO:0070374","count":1},{"id":"GO:0007158","count":1}]},{"hash":"207915972414782899","title":"Membrane repair and vesicle trafficking","description":"The listed GO terms cluster around plasma membrane repair, vesicle docking/exocytosis, secretory granule localization, and regulation of GTPase activity, all pointing to roles in membrane remodeling and vesicle trafficking. A few development-related terms may reflect tissue-specific expression but do not override the central vesicle/secretory theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001778","count":2},{"id":"GO:0006904","count":1},{"id":"GO:0016198","count":1},{"id":"GO:0048820","count":1},{"id":"GO:0032529","count":1}]},{"hash":"1075704722689691013","title":"Unknown","description":"The GO terms are highly heterogeneous, including muscle development, immune signaling (B cell/T cell differentiation, IgE isotype regulation), kidney morphogenesis, and even non-biological terms like phototropism, suggesting no coherent shared function for the cluster.","confidence":"","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":6},{"id":"GO:2001200","count":5},{"id":"GO:0050853","count":5},{"id":"GO:0009638","count":4},{"id":"GO:0048294","count":4}]},{"hash":"707742050883599493","title":"Triglyceride Storage and Lipid Droplet Regulation","description":"This cluster is dominated by terms tied to triglyceride storage and lipid droplet dynamics (organization, transport, and mobilization), plus regulatory control of TG biosynthesis and catabolism and related fatty acid oxidation, indicating a cohesive lipid droplet\u2013TG metabolism module.","confidence":"High","size":23,"edges":12,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":5},{"id":"GO:0010867","count":5},{"id":"GO:0034389","count":4},{"id":"GO:0006642","count":4},{"id":"GO:0030730","count":4}]},{"hash":"199947057877976325","title":"Cell morphogenesis and adhesion dynamics","description":"Top GO terms largely describe cytoskeletal reorganization (actin cytoskeleton), cell adhesion (cell-matrix adhesion), and morphogenetic processes (pseudohyphal growth, budding site selection, motor neuron axon guidance, neural tube closure). The mixture of yeast and animal development terms suggests a general theme of morphogenesis driven by cytoskeletal and adhesion dynamics, rather than a single, conserved pathway. ","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007124","count":3},{"id":"GO:2000251","count":3},{"id":"GO:0007118","count":3},{"id":"GO:0007121","count":3},{"id":"GO:0034446","count":3}]},{"hash":"807792736086432159","title":"PGRP-driven innate immune signaling","description":"Several top terms point to peptidoglycan recognition protein signaling and innate immune responses, with related GTPase regulation and apoptosis terms. This suggests a cluster centered on PGRP-mediated immune signaling with linked cytoskeletal and trafficking regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035021","count":2},{"id":"GO:0008625","count":2},{"id":"GO:0043547","count":2},{"id":"GO:2001136","count":2},{"id":"GO:0045671","count":2}]},{"hash":"300305902090263936","title":"ERK-regulated angiogenesis and heart development","description":"Proteins in this cluster strongly align with ERK1/ERK2 cascade activation, positive regulation of phosphorylation, and angiogenesis, with heart development and cell migration reinforcing a cardiovascular morphogenesis theme. Some terms point to neuronal signaling and immune response, but the dominant signal ties MAPK/ERK signaling to vascular and cardiac development.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0033138","count":5},{"id":"GO:0045766","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0016477","count":4}]},{"hash":"1862634552802773694","title":"Embryonic morphogenesis and organogenesis","description":"The top GO terms point to development and tissue formation across multiple embryonic lineages (left/right patterning, pancreas development, cartilage morphogenesis, trophoblast and placental formation, EMT in heart/endocardial cushion), indicating a cohesive theme of embryonic morphogenesis and lineage specification, with supporting general gene-expression processes.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"194473007848488294","title":"Cardiac electrophysiology and potassium homeostasis","description":"The top GO terms cluster around cardiac electrical activity: atrial action potential repolarization, regulation of resting membrane potential, membrane stabilization, potassium ion transport and homeostasis, and heart rate regulation via cardiac conduction, all pointing to electrophysiological properties of cardiomyocytes. A secondary term related to bone ossification appears as an outlier, but the dominant theme is cardiomyocyte membrane potential dynamics and potassium handling.","confidence":"High","size":23,"edges":9,"triangles":1,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0098914","count":16},{"id":"GO:0050976","count":15},{"id":"GO:0071805","count":14},{"id":"GO:0060075","count":14},{"id":"GO:0030007","count":13}]},{"hash":"1041155975612226113","title":"Cholesterol homeostasis and lipoprotein assembly","description":"The cluster shows strong representation of cholesterol storage, cholesterol homeostasis, cholesterol efflux, and very-low-density lipoprotein particle assembly, along with regulation of plasma lipoprotein particle levels, indicating a shared function in lipid/cholesterol handling and lipoprotein biogenesis. Other GO terms present are less central to the core theme.","confidence":"High","size":23,"edges":244,"triangles":1599,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0010878","count":2},{"id":"GO:0042986","count":2},{"id":"GO:0007224","count":2},{"id":"GO:0018009","count":2}]},{"hash":"395469476345978007","title":"Olfactory sensing and pheromone detection","description":"The cluster is dominated by GO terms related to odor perception and pheromone detection (courtship behavior, olfactory behavior, detection of chemical stimulus involved in sensory perception of smell, detection of pheromone, sensory perception of smell), suggesting a module involved in smell/pheromone signaling, likely in insects. Some secondary terms (lipid biosynthesis, ethanol metabolism, mitochondrial ribosome assembly) may reflect membrane or metabolic context but don\u2019t override the primary olfactory/pheromone theme.","confidence":"High","size":23,"edges":250,"triangles":1710,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":4},{"id":"GO:0042048","count":3},{"id":"GO:0050911","count":3},{"id":"GO:0043695","count":3},{"id":"GO:0007608","count":3}]},{"hash":"907454855404207234","title":"Ion transport and mechanosensory signaling","description":"This cluster shows strong representation of regulation of synaptic activity, sodium ion homeostasis/transport, and mechanosensory perception (touch/pain), along with pH and temperature responsiveness. Together these terms point to proteins involved in sensory signal transduction and ion balance, particularly in mechanosensory pathways and synaptic modulation, making this label a concise, representative fit.","confidence":"High","size":23,"edges":81,"triangles":154,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0060025","count":16},{"id":"GO:0055078","count":16},{"id":"GO:0010447","count":16},{"id":"GO:0035725","count":16},{"id":"GO:0050891","count":16}]},{"hash":"1074248242347867813","title":"Redox homeostasis and detoxification","description":"Most terms cluster around oxidative stress management and detoxification, e.g., cellular oxidant detoxification, cellular redox homeostasis, and cellular response to oxidative stress. While a few terms pertain to other processes, the dominant theme is redox balance and detox pathways, justifying a label centered on redox/homeostatic detox functions.","confidence":"High","size":22,"edges":99,"triangles":283,"max_degree":18,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0098869","count":12},{"id":"GO:0045454","count":10},{"id":"GO:0055114","count":9},{"id":"GO:0030416","count":7},{"id":"GO:0009636","count":6}]},{"hash":"2229849155781310033","title":"Mitosis control and genome maintenance","description":"Top GO terms indicate mitotic progression (G2/M transition, exit from mitosis, chromosome segregation) and genome maintenance activities (nucleotide-excision repair, regulation of strand invasion), along with ubiquitin-dependent proteolysis. Together these suggest a cluster of proteins coordinating cell cycle progression with DNA damage response and protein turnover. Some terms like skeletal muscle development and plant hormone signaling may be annotation noise rather than core functions. Confidence: High","confidence":"","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0048741","count":6},{"id":"GO:0045910","count":6},{"id":"GO:0060542","count":6},{"id":"GO:0010458","count":6},{"id":"GO:0070911","count":6}]},{"hash":"1598446927087087611","title":"Redox Homeostasis and Oxidative Stress Response","description":"This cluster centers on cellular redox balance and defense against oxidative damage, with strong signals in detoxification of oxidants, redox homeostasis, oxidative stress response, and glutathione-related processes such as deglutathionylation. ER-associated protein folding under oxidative conditions also fits this theme, reinforcing a common function in maintaining cellular redox status.","confidence":"High","size":22,"edges":156,"triangles":610,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0055114","count":13},{"id":"GO:0045454","count":13},{"id":"GO:1903206","count":12},{"id":"GO:0006662","count":12}]},{"hash":"1080576733438039039","title":"Developmental Regulation and Immune Signaling","description":"The cluster shows regulatory roles across development (pancreas and midbrain, post-embryonic) and transcriptional control, plus immune-related processes (leukocyte tethering/rolling, chemokine regulation) and fibrinolysis. The common thread is modulation of signaling and gene expression in developmental and immune/coagulation contexts, not a single pathway.","confidence":"Medium","size":22,"edges":68,"triangles":99,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0031017","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0030901","count":2}]},{"hash":"66834831343650201","title":"Mitotic Chromosome Assembly and Segregation","description":"The top GO terms point strongly to chromatin organization and mitotic processes (CENP-A centromeric assembly, microtubule severing, homologous chromosome segregation, mitotic Okazaki fragment processing, histone H3-K9 methylation, and general cell division). While there are hints of broader housekeeping roles (ribosomal biogenesis, ER-Golgi transport), the clustering is dominated by functions essential for chromosome maintenance and segregation during mitosis, suggesting this as the core theme for the group.","confidence":"High","size":22,"edges":217,"triangles":1293,"max_degree":21,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0061641","count":19},{"id":"GO:0051013","count":19},{"id":"GO:0030433","count":19},{"id":"GO:0042273","count":19},{"id":"GO:0051260","count":19}]},{"hash":"450502998764505941","title":"RNA Pol II transcription regulation and chromatin remodeling","description":"The top GO terms point to transcription regulation by RNA polymerase II, including DNA-templated transcription and regulation of preinitiation complex assembly, with supporting links to chromatin state via histone acetylation and nucleosome mobilization. Despite some obsolete terms, the recurrent theme is transcription control modulated by chromatin remodeling and epigenetic marks, suggesting a chromatin-associated transcription regulatory cluster. A single defense-related term appears as an outlier and does not override the central pattern.","confidence":"High","size":22,"edges":213,"triangles":1248,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043966","count":9},{"id":"GO:0000122","count":9},{"id":"GO:0042766","count":7},{"id":"GO:0050830","count":6},{"id":"GO:0006351","count":6}]},{"hash":"967015870195389219","title":"Angiogenesis and Immune Signaling in Development","description":"The cluster centers on angiogenesis and organismal development (positive regulation of angiogenesis, angiogenesis, multicellular development) while also being enriched for immune-related processes (adaptive immune response, antigen processing and presentation via MHC I) and signaling (cell-cell signaling). The presence of terms related to host interactions (symbiont entry into host cell) and inflammatory mediators (leukotriene biosynthesis) supports a theme where vascular development coexists with immune modulation. This makes \"Angiogenesis and Immune Signaling in Development\" a concise, representative label.","confidence":"High","size":22,"edges":80,"triangles":201,"max_degree":13,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0045766","count":16},{"id":"GO:0007275","count":16},{"id":"GO:0001525","count":15},{"id":"GO:0006509","count":11},{"id":"GO:0019885","count":11}]},{"hash":"2122281822808544297","title":"Toxic Stress Response and Cell Fate Regulation","description":"This cluster centers on responses to toxic substances (cadmium, ethanol) alongside signals that govern immune response, cell proliferation, migration, and apoptosis, as well as regulatory effects on nuclear export and kinetochore-associated localization. The fewGO terms suggest a unifying theme of environmental/toxic stress triggering downstream decisions about cell fate, movement, and signaling pathways (e.g., Wnt). Confidence: Medium","confidence":"Medium","size":22,"edges":79,"triangles":83,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034501","count":6},{"id":"GO:0009636","count":6},{"id":"GO:0071276","count":5},{"id":"GO:0071361","count":5},{"id":"GO:0045087","count":5}]},{"hash":"792348906101822518","title":"RNA processing and translation initiation","description":"This cluster centers on mRNA maturation and stability (polyadenylation, stability, and splicing) and on ribosome biogenesis and translation initiation (small-subunit processome assembly and eIF4F complex assembly). Together, these terms suggest proteins that coordinate RNA processing with the initiation of translation.","confidence":"High","size":22,"edges":157,"triangles":635,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":14},{"id":"GO:0010610","count":14},{"id":"GO:0048255","count":13},{"id":"GO:0034462","count":13},{"id":"GO:1901407","count":13}]},{"hash":"1494597633378665558","title":"Ribosome Biogenesis and rRNA Processing","description":"The top GO terms are dominated by maturation and processing of rRNA (5.8S, SSU, LSU) and ribosomal large subunit biogenesis, alongside translation initiation-related steps. This points to a core function in assembling and prepping ribosomes and their translation machinery, with only a few broader RNA-processing terms appearing secondarily.","confidence":"High","size":22,"edges":70,"triangles":77,"max_degree":21,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0000466","count":7},{"id":"GO:0000463","count":7},{"id":"GO:0000462","count":6},{"id":"GO:0000398","count":6},{"id":"GO:0042273","count":6}]},{"hash":"2256314920411263410","title":"Neural Development and GABAergic Signaling","description":"The GO terms show strong emphasis on neural development (spinal cord development, amygdala development) and neurotransmission via GABA, including gamma-aminobutyric acid secretion and regulation of long-term synaptic potentiation, indicating a cluster enriched for neural development and synaptic plasticity. Some terms like embryonic placenta development and hair follicle maturation appear, suggesting pleiotropy or broader developmental roles, but the dominant signal is neuronal development and inhibitory signaling.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":"lysosome organization","top_go_terms":[{"id":"GO:0021510","count":4},{"id":"GO:0061534","count":3},{"id":"GO:0001892","count":3},{"id":"GO:2001241","count":3},{"id":"GO:0035021","count":3}]},{"hash":"2057188249563078264","title":"Ion transport and membrane potential regulation","description":"This cluster is heavily enriched for transmembrane transport of various ions and small molecules (chloride, bicarbonate, sulfate, oxalate) and associated membrane potential and pH regulation, plus related processes like gastric acid secretion and sperm capacitation. The common thread is membrane transport and ionic homeostasis, with some context in sensory function. ","confidence":"High","size":22,"edges":48,"triangles":87,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0048240","count":10},{"id":"GO:0089712","count":9},{"id":"GO:0001696","count":9},{"id":"GO:0042391","count":9},{"id":"GO:0007605","count":9}]},{"hash":"2246431887258532454","title":"Immune signaling and hematopoiesis","description":"This cluster is enriched for immune- and hematopoiesis-related processes, including GM-CSF response, IL-4 production, B cell maturation, and cell migration, plus PI3K-AKT signaling. The mixture of cytokine signaling and hematopoietic development terms supports a coherent theme of immune cell activation and development.","confidence":"High","size":22,"edges":50,"triangles":31,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097011","count":9},{"id":"GO:0008286","count":8},{"id":"GO:0051973","count":7},{"id":"GO:0043491","count":7},{"id":"GO:0033160","count":7}]},{"hash":"2082407791703078868","title":"Mitotic spindle and microtubule dynamics","description":"The top GO terms are dominated by microtubule-related processes: mitotic spindle assembly and elongation, kinetochore microtubule attachment, and microtubule depolymerization, plus plus-end\u2013directed vesicle transport along microtubules and chloroplast movement, all pointing to microtubule-based cell division and intracellular trafficking. The cluster thus likely groups proteins involved in spindle function and microtubule dynamics, with some related transport roles, making this label representative.","confidence":"High","size":22,"edges":118,"triangles":331,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000742","count":18},{"id":"GO:0072092","count":12},{"id":"GO:0072383","count":11},{"id":"GO:0010938","count":11},{"id":"GO:0060404","count":11}]},{"hash":"2112528727686328748","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0032543","count":4},{"id":"GO:0001682","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0000027","count":2}]},{"hash":"2303960523797843329","title":"Unknown","description":"The GO terms are highly diverse, including DNA-templated transcription, sensory perception of smell, meiotic cell cycle regulation, cGMP signaling, sarcomere organization, bud neck localization, cardiac muscle proliferation, guanylyl cyclase signaling, potassium transport, and small GTPase signaling. This mix does not converge on a single cohesive function or theme, with clear signals of transcriptional regulation, signaling pathways, and muscle/structural processes as well as outlier terms like olfactory perception. Therefore a meaningful, specific label cannot be assigned.","confidence":"","size":22,"edges":140,"triangles":576,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":9},{"id":"GO:0007608","count":8},{"id":"GO:0051447","count":8},{"id":"GO:0071321","count":8},{"id":"GO:0045214","count":8}]},{"hash":"2047148405516906598","title":"Lipid biosynthesis and fatty acid transport","description":"These terms converge on lipid metabolism, including lipoteichoic acid biosynthesis (a bacterial cell envelope lipid), long-chain/very long-chain fatty acid transport and metabolism, and related acetyl-CoA\u2013linked lipid biosynthetic steps. While there are plant- or microbe-specific outliers (seed coat development, phenylpropanoid metabolism, siderophore biosynthesis), the dominant signal across the cluster is lipid biosynthesis and fatty acid processing, suggesting a cohesive functional theme around membrane/lipid assembly and transport. ","confidence":"Medium","size":22,"edges":75,"triangles":221,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070395","count":13},{"id":"GO:0010214","count":12},{"id":"GO:0009698","count":12},{"id":"GO:0008206","count":12},{"id":"GO:0044539","count":12}]},{"hash":"667121556556575649","title":"Mitotic DNA replication machinery","description":"This cluster shows clear signals of DNA replication and cell cycle function, with terms like mitotic DNA replication initiation, DNA strand elongation involved in mitotic DNA replication, and GINS complex assembly pointing to replication machinery active during mitosis. Other terms such as viral process, methylation, and proteasomal regulation appear as secondary or broader associations, but they do not define the primary theme of the cluster. Therefore, a replication/cell cycle label is appropriate, though the mix of non-core terms lowers the confidence slightly.","confidence":"Medium","size":22,"edges":24,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0043695","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0032259","count":1},{"id":"GO:0032435","count":1}]},{"hash":"220651102149449139","title":"Actin Dynamics and Cell Migration","description":"These proteins show a clear focus on cytoskeletal remodeling (actin filament bundle assembly) and cell movement (migration), supported by mechanical signaling and receptor-mediated pathways (ephrin signaling, receptor localization to synapse). Ubiquitination indicates regulatory control over these processes, with some broader cell-cycle associations reflecting general cellular regulation. Therefore, the cluster represents actin-driven migration and related signaling.","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":5},{"id":"GO:0071260","count":5},{"id":"GO:0016477","count":4},{"id":"GO:0008285","count":4},{"id":"GO:1900383","count":4}]},{"hash":"1270502279587669407","title":"Immune Regulation and Ubiquitination","description":"The top GO terms cluster around immune system modulation (regulation of memory T cell differentiation; negative regulation of IgE isotype switching; negative regulation of mast cell cytokine production) and ubiquitin-related processes (negative regulation of protein ubiquitination; K33-linked ubiquitination), suggesting a theme of ubiquitin-mediated control of immune signaling. Some terms appear unrelated (phototropism, distal tubule morphogenesis, male/female analia development), which may reflect annotation noise, but the strongest, coherent signal points to immune regulation via ubiquitination pathways.","confidence":"Medium","size":22,"edges":35,"triangles":31,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0009638","count":18},{"id":"GO:0048294","count":18},{"id":"GO:0043380","count":18},{"id":"GO:0045497","count":18},{"id":"GO:0031397","count":18}]},{"hash":"988084000716644487","title":"Proteostasis and Autophagy Stress Response","description":"This cluster centers on cellular quality control for misfolded proteins (cellular response to misfolded protein, aggresome assembly, autophagosome maturation) and includes RNA processing and transcription terms, suggesting coordination between protein quality control and gene expression. Energy-related terms (ATP biosynthesis, complex III assembly) provide context for the metabolic support of stress responses.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0071218","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0070842","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0030420","count":2}]},{"hash":"1533520045633740519","title":"Inflammatory signaling and apoptotic stress response","description":"The cluster shows enrichment for inflammatory and stress-related GO terms, including cellular response to lipopolysaccharide, TNF-mediated signaling, and NF-kappaB regulation, as well as an intrinsic apoptotic pathway in response to DNA damage. These collectively indicate a coherent theme of innate immune/inflammatory signaling and stress-induced apoptosis. Some terms (e.g., nucleotide catabolism and plant hypersensitive response) appear ancillary and do not alter the main theme. ","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":2},{"id":"GO:0018298","count":2},{"id":"GO:0033209","count":1},{"id":"GO:0034051","count":1},{"id":"GO:0042771","count":1}]},{"hash":"784559685590398038","title":"Drosophila metamorphosis and innate immune melanization","description":"The top GO terms point to insect development (metamorphosis, cuticle formation) and innate immunity (Toll signaling, antimicrobial peptide production, melanization). The presence of zymogen activation suggests serine protease cascades central to both melanization and Toll pathway activation, tying development with immune defense in Drosophila; despite some obsolete terms, the cluster coherently centers on metamorphosis-related processes and melanization/immune responses.","confidence":"High","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007552","count":3},{"id":"GO:0035071","count":3},{"id":"GO:0008363","count":1},{"id":"GO:0045752","count":1},{"id":"GO:0006964","count":1}]},{"hash":"445736521175449804","title":"Embryonic Organogenesis and Neural Differentiation","description":"The Top Terms span multiple embryonic development processes (limb, skeletal, craniofacial, and pituitary organogenesis) and neural differentiation, including neuronal fate commitment and gene-expression regulation, pointing to a cohesive developmental program cluster.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0021983","count":3},{"id":"GO:0021524","count":3},{"id":"GO:0003148","count":3},{"id":"GO:0035116","count":3}]},{"hash":"2057714254902365786","title":"Embryonic patterning and organ morphogenesis","description":"The terms point to a broad developmental program rather than a single tissue, with left/right patterning, various morphogenesis (cartilage, eye, palate, muscle, placenta-related EMT), and endocrine system development across multiple organs. This pattern indicates a cluster of proteins involved in coordinating embryonic tissue patterning and organ formation.","confidence":"High","size":22,"edges":11,"triangles":3,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":7},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"233082798650425955","title":"Multi-tissue Developmental Regulation","description":"The top GO terms cover diverse developmental contexts (larval cuticle, midbrain, pancreas, post-embryonic development) and regulatory processes (transcription regulation, cell proliferation, immune signaling). This pattern points to proteins involved in broad developmental programs with regulatory roles across tissues, rather than a single pathway.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0045944","count":2},{"id":"GO:0031017","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0051919","count":2}]},{"hash":"673912283864077373","title":"Kidney and vascular morphogenesis with coagulation regulation","description":"This cluster centers on development-related GO terms: kidney development and epithelium morphogenesis, coupled with angiogenesis regulation, NO biosynthesis, TGF-\u03b2 production, and coagulation/fibrinolysis control. The convergence of tissue morphogenesis and vascular/coagulation pathways suggests a cohesive program governing kidney and blood vessel formation with remodeling. Confidence: High","confidence":"","size":22,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045429","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0045766","count":3}]},{"hash":"168571336241320454","title":"Developmental transcriptional regulation","description":"The cluster is dominated by GO terms for positive regulation of transcription by RNA polymerase II, alongside multiple development-related terms (exocrine pancreas development, midbrain development, post-embryonic development) and regulation of proliferation, suggesting a shared role in controlling gene expression during development. While some terms touch on immune signaling, the core theme is transcriptional regulation linked to developmental processes.","confidence":"High","size":22,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":22},{"id":"GO:0031017","count":22},{"id":"GO:1903238","count":22},{"id":"GO:0051919","count":22},{"id":"GO:0030901","count":22}]},{"hash":"987610362987690796","title":"Embryonic development and tissue morphogenesis","description":"The GO terms point to a broad developmental theme, including mesoderm development, cartilage morphogenesis, hair follicle morphogenesis, pancreatic cell development, and left-right patterning, suggesting a cluster of proteins involved in tissue formation and patterning across multiple lineages. A minority terms (lipopolysaccharide response, mRNA splicing) are ancillary.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032298","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0060972","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060536","count":1}]},{"hash":"1989439237939485877","title":"Embryonic development and patterning","description":"The top GO terms point to broad developmental processes such as left-right patterning, tissue morphogenesis (cartilage, pancreas), EMT during heart development, placenta/endocrine development, and axis specification, suggesting a cohesive cluster focused on embryogenesis and patterning across tissues and species.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":8},{"id":"GO:0003323","count":8},{"id":"GO:0060536","count":8},{"id":"GO:0060707","count":8},{"id":"GO:0003198","count":8}]},{"hash":"1167903679979201865","title":"Ubiquitin-Dependent Regulation","description":"The top GO terms show a recurring theme around ubiquitin-mediated processes, including ubiquitin-dependent protein catabolic process and negative regulation of protein ubiquitination, suggesting a core link to ubiquitin turnover and modification. Other terms (transcription, cytoskeleton, signaling) appear more peripheral, but the ubiquitin-related terms provide the strongest common thread for this cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0048549","count":2},{"id":"GO:0051639","count":2},{"id":"GO:0016055","count":2}]},{"hash":"1893916677273647731","title":"Neural and vascular development","description":"This cluster centers on angiogenesis regulation (positive and negative), endothelial chemotaxis, axon guidance, and nervous system development, with collagen fibril organization suggesting ECM remodeling. Together, these terms point to coordinated neural and vascular development and tissue remodeling, with immune-related terms being less central to the core theme.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016525","count":10},{"id":"GO:0030199","count":10},{"id":"GO:0045766","count":9},{"id":"GO:0051965","count":8},{"id":"GO:0006958","count":7}]},{"hash":"412547879697443924","title":"Phosphorylation-Driven Transcription and Development","description":"Top terms emphasize phosphorylation events and transcriptional regulation, with developmental signaling (axonogenesis, angiogenesis) and abscisic acid signaling, suggesting a regulatory protein cluster that modulates gene expression in response to signals. Some metabolic salvage terms are listed as obsolete, but the core pattern is phosphorylation-linked transcription and development.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019509","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0016310","count":3}]},{"hash":"531634756096097938","title":"Insect Neuropeptide Signaling and Reproductive Behavior","description":"This cluster shows GO terms centered on neuropeptide signaling and neural control of behavior (neurotransmission, larval locomotion, mating-related behaviors) plus reproductive development aspects (egg-laying regulation, eggshell formation). The convergence on neural signaling and reproduction-related processes suggests a neuroendocrine theme in insects, despite some outliers. ","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060054","count":2},{"id":"GO:0010459","count":1},{"id":"GO:0002209","count":1},{"id":"GO:1901045","count":1},{"id":"GO:0007218","count":1}]},{"hash":"1850011983376497269","title":"Chemosensory perception and pheromone signaling","description":"These proteins are enriched for chemical sensing and related behavioral responses, including detection and response to CO2, bitter taste, caffeine, insecticides, and L-canavanine, as well as chemosensory behavior, negative phototaxis, and pheromone-based courtship cues. This cohesive set points to a chemosensory signaling cluster driving environmental cue detection and behavioral responses.","confidence":"High","size":22,"edges":115,"triangles":232,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0003031","count":8},{"id":"GO:0031000","count":8},{"id":"GO:0017085","count":8},{"id":"GO:1901354","count":8},{"id":"GO:0050913","count":8}]},{"hash":"1184131584105576570","title":"Unknown","description":"There are no GO terms listed for this cluster and the network has no edges or triangles, so there is no evident shared function to base a label on. Although many proteins were re-added by ReCIPE, this cluster lacks a coherent functional theme to assign a specific name.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"534376906492372424","title":"Membrane Phospholipid Biosynthesis","description":"Reason: The top GO terms cluster around biosynthesis of key phospholipids (phosphatidylglycerol, phosphatidylethanolamine, phosphatidylserine) and related lipid mediators (platelet activating factor), with a note on regulation of phosphatidylinositol biosynthesis. While a few terms (heme biosynthesis, cell cycle regulation) are peripheral, the dominant signal is lipid membrane biosynthesis and lipid metabolism, justifying this label.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006655","count":1},{"id":"GO:0006663","count":1},{"id":"GO:1905711","count":1},{"id":"GO:0006659","count":1},{"id":"GO:0006646","count":1}]},{"hash":"496618855970088465","title":"Immune response and development signaling","description":"This cluster is enriched for immune-related terms like defense response to bacterium, complement activation, and mast cell degranulation, indicating involvement in immune signaling. It also includes developmental terms such as face morphogenesis and metamorphosis, along with ERK cascade regulation and angiogenesis, suggesting a link between immune signaling and developmental/tissue-remodeling processes. Overall, the proteins likely participate in immune responses with notable developmental signaling cross-talk.","confidence":"Medium","size":22,"edges":23,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042742","count":4},{"id":"GO:0060325","count":4},{"id":"GO:0019835","count":3},{"id":"GO:0007552","count":2},{"id":"GO:0035071","count":2}]},{"hash":"1995477279392491641","title":"Membrane Transport of Nutrients and Ions","description":"Most of the top GO terms describe various transmembrane transport activities for diverse substrates (biotin, glucose, pantothenate, myo-inositol, xenobiotics, nitrate/nitrite, fucose) and ions (sodium export). Although there is a mention of acetylcholine biosynthesis, the dominant theme is transport across membranes for multiple substrates, suggesting these proteins are broadly acting transporters. Confidence: High","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0015878","count":8},{"id":"GO:1904659","count":8},{"id":"GO:0015887","count":8},{"id":"GO:0071436","count":8},{"id":"GO:0015798","count":8}]},{"hash":"1064547853638037353","title":"Ion and Small Molecule Transmembrane Transport","description":"The cluster is dominated by GO terms describing transport across membranes for diverse substrates\u2014ions (potassium and sodium), nitrite and nitrate, sialic acid, vitamins, and xenobiotics\u2014with a couple metabolism-related terms. This shared theme points to membrane transport functionality of these proteins as the unifying feature of the cluster.","confidence":"High","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015739","count":16},{"id":"GO:0071805","count":16},{"id":"GO:0015707","count":16},{"id":"GO:0006855","count":15},{"id":"GO:0042128","count":15}]},{"hash":"2245899041697606403","title":"Membrane Transporters (Nutrients & Ions)","description":"Top GO terms are dominated by transmembrane transport of nutrients and ions (biotin, glucose, pantothenate, myo-inositol, sodium export). This points to a cluster of membrane transporter proteins. While there are a couple of outlier terms related to nervous system processes and acetylcholine biosynthesis, the primary signal is transporter activity, supporting a transporter-centered label.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015878","count":5},{"id":"GO:1904659","count":5},{"id":"GO:0015887","count":5},{"id":"GO:0071436","count":5},{"id":"GO:0015798","count":5}]},{"hash":"246939224303185886","title":"DNA replication and chromatin maintenance","description":"This cluster is dominated by GO terms related to DNA replication, mitotic chromosome condensation, and double-strand break repair, with supporting terms for heterochromatin formation, Cajal body organization, and DNA-templated transcription. Together these imply a group of nuclear proteins focused on genome maintenance and regulation of chromatin states, rather than metabolic or signaling roles. The t-circle terms hint at telomere-associated chromatin contexts but do not override the central theme of replication and chromatin dynamics.","confidence":"High","size":21,"edges":195,"triangles":1150,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007076","count":2},{"id":"GO:1904431","count":2},{"id":"GO:0045003","count":2},{"id":"GO:0090656","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1768683418605141072","title":"Nuclear RNA Processing and Transcription Regulation","description":"This cluster centers on nuclear gene expression processes: RNA maturation (splicing and processing), transcriptional regulation (Pol II regulation and DNA replication initiation control), and ribosomal subunit export, with supportive calcium/calmodulin\u2013NFAT signaling links. The combined GO terms point to a cohesive theme of nuclear RNA processing and transcriptional control, with ancillary regulatory signaling.","confidence":"Medium","size":21,"edges":39,"triangles":46,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006378","count":3},{"id":"GO:0032298","count":2},{"id":"GO:0000055","count":2},{"id":"GO:1903026","count":2}]},{"hash":"294029944684819787","title":"Nuclear Transport and Mitotic Regulation","description":"The top GO terms cluster around nuclear transport activities (NLS-bearing import, tRNA export, nuclear mRNA decay) and mitotic processes (mitotic cell cycle, mitotic nuclear membrane disassembly), with supporting signals in NF-kappaB and Ras pathways and cell-shape regulation\u2014together suggesting proteins coordinating nuclear transport with mitosis and related RNA processing during cell division.","confidence":"High","size":21,"edges":17,"triangles":7,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0006409","count":3},{"id":"GO:0008360","count":3},{"id":"GO:0000288","count":2}]},{"hash":"515855029624396240","title":"Cell cycle and development","description":"This cluster centers on cell cycle control (G2/M transition, mitotic DNA damage checkpoint, meiotic cell cycle), plus kinetochore localization and transcription/RNA processing, all tied to broader multicellular development (axonal development, development). The mix suggests proteins coordinating division with developmental programs rather than a single pathway; the viral process term appears as noise. ","confidence":"Medium","size":21,"edges":121,"triangles":282,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":4},{"id":"GO:0033160","count":2},{"id":"GO:0007409","count":2},{"id":"GO:0006397","count":2},{"id":"GO:0034501","count":2}]},{"hash":"1425564453503942945","title":"RNA splicing and transcription regulation","description":"The cluster is dominated by GO terms related to RNA processing and splicing (alternative mRNA splicing via spliceosome, RNA splicing, mRNA processing, regulation of alternative splicing) along with transcription-related terms (transcription elongation by RNA polymerase II, DNA-templated transcription, regulation of transcription). This suggests a cohesive group of proteins involved in RNA maturation and control of gene expression, rather than disparate pathways.","confidence":"High","size":21,"edges":201,"triangles":1173,"max_degree":20,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000380","count":4},{"id":"GO:0030422","count":3},{"id":"GO:0051533","count":3},{"id":"GO:0035196","count":3},{"id":"GO:0006368","count":3}]},{"hash":"757293099512556573","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":16},{"id":"GO:0031047","count":16},{"id":"GO:0000398","count":10},{"id":"GO:0031124","count":9},{"id":"GO:0001178","count":9}]},{"hash":"1003063599791916497","title":"DNA Replication and Repair Network","description":"Most terms point to DNA replication and DNA damage response, including DNA replication, primer synthesis, nucleotide-excision repair, and the SOS response. While a couple of terms (e.g., hypoxia response, hair cell differentiation) are less directly related, the dominant pattern is core DNA replication and genome maintenance, suggesting a replication/repair module. ","confidence":"High","size":21,"edges":208,"triangles":1293,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":12},{"id":"GO:0019079","count":10},{"id":"GO:0006268","count":9},{"id":"GO:0009432","count":8},{"id":"GO:0001666","count":8}]},{"hash":"33633516737994542","title":"Diverse Chemical Metabolism and Catabolism","description":"This cluster is enriched for a range of catabolic and metabolic GO terms across diverse chemicals\u2014lipids (triglyceride catabolic), nucleosides (uracil catabolic), glucuronosides, alkaloids, and xenobiotics (1,2-dichloroethane catabolic). There is also detox- or response-related signaling terms and some biosynthetic metabolism terms, but the unifying theme is the breakdown and processing of diverse chemical compounds. ","confidence":"High","size":21,"edges":158,"triangles":670,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":18},{"id":"GO:0017000","count":14},{"id":"GO:0097755","count":13},{"id":"GO:2000124","count":13},{"id":"GO:0019260","count":13}]},{"hash":"2183595432972795670","title":"Cytoskeletal remodeling in neurons and mitosis","description":"These terms point to cytoskeletal dynamics and remodeling. Key themes include neuron migration/differentiation and mechanosensory regulation, alongside mitotic processes (spindle pole body duplication, cytokinesis) and protein polymerization. Together they suggest a cluster of proteins involved in cytoskeletal organization impacting neuronal development and cell division.","confidence":"Medium","size":21,"edges":16,"triangles":12,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001764","count":7},{"id":"GO:0007049","count":5},{"id":"GO:1903087","count":5},{"id":"GO:0051258","count":5},{"id":"GO:1905789","count":5}]},{"hash":"1352130201949017596","title":"Developmental ECM remodeling and neural signaling","description":"The GO terms point to organ development (lung, kidney, pregnancy) and extracellular matrix remodeling (collagen fibril organization, regulation of ECM assembly), suggesting tissue formation with ECM changes. In addition, neural-related terms (regulation of NMDA receptor activity, astrocyte differentiation) indicate CNS involvement alongside development. Overall, these terms collectively support a theme of developmental remodeling with neural signaling.","confidence":"Medium","size":21,"edges":40,"triangles":39,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0035690","count":2},{"id":"GO:0006685","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0007565","count":2}]},{"hash":"760535389893836896","title":"ECM remodeling and vascular development","description":"This cluster centers on extracellular matrix remodeling and vascular/inflammatory processes, as shown by proteolysis and collagen fibril organization, VEGF production/signaling, and endothelial tube morphogenesis. Additional terms like complement activation and neutrophil extravasation point to an inflammatory/nets-near-vasculature context; a few terms (fertilization, axonal fasciculation) reflect broader developmental roles but do not dominate the theme. Overall, the common thread is ECM remodeling coupled with angiogenic and immune-related signaling.","confidence":"Medium","size":21,"edges":11,"triangles":2,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006508","count":8},{"id":"GO:2000391","count":8},{"id":"GO:0030199","count":7},{"id":"GO:0007338","count":7},{"id":"GO:0006958","count":7}]},{"hash":"1625232412981200525","title":"Germline development and piRNA pathway","description":"The cluster is dominated by GO terms tied to germline biology and RNA silencing, such as pole plasm mRNA localization, piRNA processing, spermatogenesis, and dorsal/ventral axis polarity, indicating a cohesive theme of germ cell development and transposon silencing. Some terms (e.g., lens morphogenesis) appear as outliers but do not override the overall germline/piRNA signal.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002089","count":4},{"id":"GO:0000335","count":4},{"id":"GO:0045451","count":4},{"id":"GO:0007140","count":4},{"id":"GO:0030423","count":4}]},{"hash":"1677757633150325338","title":"Amino acid biosynthesis and cofactor metabolism","description":"The top GO terms cluster around biosynthesis of several amino acids (isoleucine, valine, proline) and pantothenate, along with NADPH regeneration. This suggests proteins are involved in amino acid and cofactor biosynthesis and their redox-linked metabolism, with a few incidental catabolic or sporulation-related terms that broaden the metabolic context.","confidence":"Medium","size":21,"edges":129,"triangles":384,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006740","count":7},{"id":"GO:0046392","count":7},{"id":"GO:0009097","count":7},{"id":"GO:0009099","count":7}]},{"hash":"791234385157180794","title":"Embryonic tissue and organ morphogenesis","description":"The terms span development across multiple tissues and organs (muscle, heart/outflow tract, hindlimb, eye, placenta, prostate, habenula), emphasizing morphogenesis and organ formation rather than a single tissue-specific function. This broad developmental theme best captures the cluster.","confidence":"High","size":21,"edges":3,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007519","count":12},{"id":"GO:0003148","count":12},{"id":"GO:0008584","count":12},{"id":"GO:0035116","count":12},{"id":"GO:0007507","count":12}]},{"hash":"1112198909978439944","title":"Excitatory synapse assembly and plasticity","description":"The cluster shows strong representation for GO terms tied to excitatory synapse formation and function, including excitatory synapse assembly, positive regulation of excitatory postsynaptic potential, neuron cell-cell adhesion, and regulation of receptor recycling, suggesting a theme of neuronal connectivity and modulatory synaptic activity. Some outlier terms (defense response to Gram-positive bacteria, floral organ morphogenesis) may reflect annotation noise, but the core signals point to synaptic development and plasticity.","confidence":"Medium","size":21,"edges":131,"triangles":369,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":8},{"id":"GO:0051262","count":6},{"id":"GO:0048444","count":6},{"id":"GO:1904861","count":6},{"id":"GO:0001919","count":6}]},{"hash":"2021815542280733010","title":"Glutamatergic synapse assembly and signaling","description":"This cluster is enriched for terms about forming and signaling at glutamatergic synapses (positive regulation of synapse assembly, receptor clustering, glutamatergic transmission, excitatory postsynaptic potential) and neural development (nervous system development, visual learning), indicating proteins involved in synapse formation and excitatory transmission in the nervous system.","confidence":"High","size":21,"edges":8,"triangles":2,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051965","count":10},{"id":"GO:0008542","count":9},{"id":"GO:0043113","count":9},{"id":"GO:0035249","count":8},{"id":"GO:0007275","count":8}]},{"hash":"162883196361218639","title":"Muscle development and protein synthesis","description":"The cluster shows enrichment for skeletal muscle\u2013related processes (muscle contraction, muscle cell differentiation, and muscle tissue development), along with translation-related terms (translation, translational initiation, ribosome biogenesis) and general protein synthesis. This points to a cohesive role in muscle growth and production of muscle proteins, with supportive signals for stress responses in muscle (e.g., hypoxia regulation, cardiac muscle hypertrophy). A few outliers may reflect broader annotation reuse rather than core function.","confidence":"Medium","size":21,"edges":13,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0003009","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0035914","count":2}]},{"hash":"1300007868404108584","title":"mRNA processing and splicing machinery","description":"The top GO terms cluster around spliceosome-mediated splicing, mRNA stability and stabilization, polyadenylation regulation, and processosome assembly, indicating a group of nuclear RNA processing factors involved in pre-mRNA maturation and transcript regulation.","confidence":"High","size":21,"edges":30,"triangles":17,"max_degree":8,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0010610","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0048255","count":8},{"id":"GO:0034462","count":8}]},{"hash":"2300283792475935767","title":"Eye development and patterning","description":"The top GO terms cluster around embryonic development with a strong emphasis on eye morphogenesis and pattern formation (eye morphogenesis, camera-type eye development, left/right pattern formation), plus multicellular development. While a couple terms are less directly related (sarcomere organization, DNA damage checkpoint), the dominant theme is ocular development and body plan patterning, justifying this label as representative of the cluster.","confidence":"Medium","size":21,"edges":61,"triangles":48,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0060972","count":4},{"id":"GO:0048048","count":4},{"id":"GO:0043010","count":4},{"id":"GO:0071455","count":4}]},{"hash":"1665266562929388445","title":"Cross-domain Energy Metabolism","description":"The cluster is dominated by terms for energy generation across organisms, including photosynthesis, mitochondrial respiration, TCA cycle, fermentation, and methanogenesis, suggesting a shared function in energy production. A few terms like flagellum assembly are peripheral but may be co-associated in motility-related energy contexts.","confidence":"High","size":21,"edges":204,"triangles":1227,"max_degree":20,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0019684","count":6},{"id":"GO:0042775","count":4},{"id":"GO:0006122","count":4},{"id":"GO:0015979","count":4}]},{"hash":"544424678711152634","title":"Cerebellar development and neural signaling","description":"The strongest GO terms point to cerebellar cortex formation and Bergmann glial cell differentiation, suggesting a cerebellar development theme. Other terms (insulin/T cell signaling, cell cycle regulation, mRNA capping) are broader and may reflect miscellaneous roles of cluster proteins, so the cerebellar development angle is plausible but not exclusive. ","confidence":"Medium","size":21,"edges":61,"triangles":70,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0060020","count":2},{"id":"GO:0021697","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0050852","count":2}]},{"hash":"1530074783084902123","title":"Virus-host genome integration and mitochondrial function","description":"This cluster features GO terms pointing to both viral/symbiont interactions with the host genome (DNA integration, proviral latency, RNA-templated DNA synthesis, DNA replication) and mitochondrial processes (electron transport, complex II assembly), with translation as a general cellular process in common. The combination suggests a theme of host genome manipulation by viruses/symbionts alongside mitochondrial activity, rather than a single clean functional module. ","confidence":"Medium","size":21,"edges":206,"triangles":1257,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0034553","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006278","count":1},{"id":"GO:0075732","count":1}]},{"hash":"509993010111038671","title":"Mitochondrial Fe-S Cluster Biogenesis and Metal Homeostasis","description":"The top GO terms center on iron-sulfur cluster assembly and maturation, plus copper ion homeostasis and mitochondrial targeting, indicating a core function in mitochondrial metal cofactor biogenesis and maintenance. Some nervous system and heart-related terms may reflect tissue-specific energy demands rather than core cluster biology, but the predominant signal is Fe-S cluster biogenesis within mitochondria.","confidence":"Medium","size":21,"edges":78,"triangles":162,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0097428","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0007399","count":2},{"id":"GO:0016226","count":2},{"id":"GO:0006626","count":2}]},{"hash":"619771344408796429","title":"Developmental Growth Factor Signaling Regulation","description":"The top GO terms cluster around negative regulation of PDGF receptor signaling and vascular smooth muscle proliferation, indicating regulation of growth factor signaling in vascular development. Additional terms touch on broader developmental processes (lung development) and lineage/differentiation events, suggesting a developmental gene set with an emphasis on signaling control, though some terms are more general. Overall, the label reflects the central theme of developmental regulation of growth factor signaling.","confidence":"Medium","size":21,"edges":36,"triangles":19,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2000587","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0010735","count":2},{"id":"GO:0002191","count":1},{"id":"GO:0030324","count":1}]},{"hash":"317220212077078067","title":"Unknown","description":"The terms span plant light response, immune regulation, development, and ubiquitination, with no single coherent function tying them together, so a meaningful label cannot be assigned.","confidence":"","size":21,"edges":21,"triangles":4,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0009638","count":4},{"id":"GO:0048294","count":4},{"id":"GO:0043380","count":4},{"id":"GO:0045497","count":4},{"id":"GO:0031397","count":4}]},{"hash":"1046529623344191774","title":"Insect sensory detection and developmental fate","description":"Most of the top GO terms point to sensory perception and developmental outcomes in insects, including detection of pheromone and CO2, response to caffeine, and cell fate specification (wing and cone cells) as well as spermatid differentiation. A couple of terms (ER protein transport and NK cell regulation) appear as single, divergent annotations, suggesting noise rather than a shared function. This partial coherence supports a label centered on insect sensory and developmental roles, but the presence of unrelated terms yields a cautious Low confidence.","confidence":"Low","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0034620","count":1},{"id":"GO:0048515","count":1},{"id":"GO:1904211","count":1},{"id":"GO:0042676","count":1}]},{"hash":"759548599603600193","title":"Embryogenesis and Organogenesis","description":"The proteins show a cohesive enrichment for embryonic development and organ formation, including left-right patterning, placenta/placental trophoblast differentiation, cartilage morphogenesis, endocrine system development, and epithelial-to-mesenchymal transitions during heart/endocardial cushion formation, indicating a developmental/organogenesis theme rather than a single biochemical pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"1537019938513427549","title":"Bacterial cell wall and glycan biosynthesis","description":"The GO terms point to processes involved in building and modifying the bacterial cell envelope, including peptidoglycan biosynthesis, lipoteichoic acid biosynthesis, dolichol-linked oligosaccharide biosynthesis, and glycolipid biosynthesis, plus cell wall organization and regulation of cell shape. The presence of lipoteichoic acid and related glycan-related processes strongly suggests a Gram-positive cell wall/glycan synthesis theme, with carbohydrate metabolism and antibiotic metabolic processes providing contextual support. Overall, a cohesive label is \"Bacterial cell wall and glycan biosynthesis.\" ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":1},{"id":"GO:0071555","count":1},{"id":"GO:0009252","count":1},{"id":"GO:0008360","count":1},{"id":"GO:0006488","count":1}]},{"hash":"2272710402714885046","title":"ER-Golgi Vesicle Trafficking","description":"The cluster is enriched for GO terms tied to vesicle transport between the endoplasmic reticulum and Golgi (ER-to-Golgi transport, COPII budding), and protein localization to the ER, indicating a cohesive functional theme around movement of proteins through the early secretory pathway. Other terms related to general protein transport and retrograde trafficking to the Golgi reinforce this trafficking-centric role.","confidence":"High","size":21,"edges":53,"triangles":48,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0015031","count":2},{"id":"GO:0042147","count":2},{"id":"GO:0046485","count":1},{"id":"GO:0036444","count":1}]},{"hash":"1661358953515301677","title":"Mitochondria-ER protein import and cristae dynamics","description":"The cluster centers on mitochondrial protein import and assembly (matrix import, outer membrane insertion), alongside cristae formation and regulation, linking to ER-associated processes such as ER-Golgi trafficking and calcium signaling. The presence of mitochondrial and ER calcium regulation terms and a note on intrinsic apoptotic signaling supports a cohesive module in mitochondrial biogenesis, cristae architecture, and ER-mitochondria communication that governs calcium-dependent apoptosis.","confidence":"High","size":21,"edges":87,"triangles":130,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":3},{"id":"GO:0034975","count":2},{"id":"GO:0045040","count":2},{"id":"GO:0042407","count":1},{"id":"GO:1903850","count":1}]},{"hash":"2053930662977560444","title":"Adipogenesis with immune and cytoskeletal signaling","description":"The terms show fat cell differentiation and macrophage foam cell differentiation, along with cytokine response, wound healing, actin filament bundle assembly, and calcium import, suggesting a cluster involved in adipocyte development coupled with immune signaling and cytoskeletal/ion transport regulation; the presence of both adipogenesis-related and inflammatory processes indicates a role in adipose-immune interactions and remodeling.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010745","count":2},{"id":"GO:0045444","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0098703","count":2}]},{"hash":"130191829568930198","title":"DNA damage response and ubiquitin-proteasome regulation","description":"The top GO terms cluster around DNA damage and stress responses (gamma radiation, mitotic G1 DNA damage checkpoint signaling, replication senescence) and the ubiquitin-proteasome system (ubiquitin-dependent protein catabolic process, regulation of ubiquitination), with supporting signals from ROS metabolism and metabolic stress. This points to a cohesive module coordinating DNA damage sensing, apoptosis/senescence decisions, and targeted protein turnover. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071480","count":2},{"id":"GO:0036342","count":2},{"id":"GO:1900119","count":2},{"id":"GO:0090399","count":2},{"id":"GO:2000379","count":2}]},{"hash":"439302485686611490","title":"Embryogenesis and organogenesis","description":"These proteins show a cohesive theme of developmental patterning and tissue formation, spanning axis specification (left/right, dorsal/ventral), placenta/embryonic development (trophoblast giant cells, endocrine system development, and placental differentiation), and organogenesis processes (cartilage morphogenesis, pancreatic cell development, EMT in heart formation). The spliceosome-related term appears more general, but the dominant terms point to a developmental, organ-forming cluster.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3}]},{"hash":"1253863673183198056","title":"Neural development and synaptic assembly","description":"The GO terms are heavily weighted toward neural connectivity and synapse biology\u2014positive regulation of synapse assembly, axon guidance, cell-cell adhesion, and ERK signaling\u2014indicating roles in synapse formation and neuronal growth. While some terms refer to broader development (kidney/heart development), the predominance of neural-related terms and remodeling of dendritic spines suggests a coherent cluster of proteins involved in neural development and synaptic assembly/maintenance, with adhesion and signaling components.","confidence":"Medium","size":21,"edges":43,"triangles":26,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0051965","count":6},{"id":"GO:0007411","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0001822","count":5}]},{"hash":"822523836300631373","title":"Embryonic patterning and organogenesis","description":"These terms cluster around embryonic development, tissue patterning, and organogenesis across multiple lineages (left-right patterning, pancreatic development, cartilage formation, trophoblast differentiation, EMT, endocrine development, retina, and neuron migration), suggesting a broad developmental program rather than a single pathway.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4}]},{"hash":"1044536241320959006","title":"Unknown","description":"The Top Terms span very diverse processes: larval chitin-based cuticle development, xenobiotic transport, ubiquitination, mechanical stimulus response, axonogenesis, calcium release signaling, B cell proliferation, nitrate and nitrite metabolism, and fucose metabolism. The cluster has minimal connectivity (one edge, zero triangles) and no clear central function tying these terms together, suggesting the proteins do not share a single coherent biological role. Therefore a specific functional label is not warranted; mark as Unknown.","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0007409","count":2}]},{"hash":"1481163392463730219","title":"GPCR Signaling and ERK Cascade","description":"The cluster is enriched for GO terms tied to G protein-coupled receptor signaling and downstream ERK cascade (adrenergic receptor signaling, adenylate cyclase activation, ERK activation), plus related immune and vascular processes (gastrin-induced acid secretion, eosinophil chemotaxis, platelet activation). These converge on GPCR-mediated signal transduction across diverse tissues, suggesting a coherent theme of GPCR signaling in this cluster.","confidence":"High","size":21,"edges":47,"triangles":32,"max_degree":11,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001698","count":19},{"id":"GO:0072224","count":19},{"id":"GO:0048290","count":19},{"id":"GO:0042752","count":19},{"id":"GO:0071880","count":19}]},{"hash":"592246554853752183","title":"Coagulation and Fibrinolysis with Complement Activation","description":"The cluster is dominated by terms related to blood coagulation and fibrinolysis (Factor XII activation, plasminogen activation regulation, fibrinogen level regulation) and includes complement activation pathways, suggesting a vascular/hemostasis module with immune interaction. While a couple terms (digestion, transcriptional regulation) are less connected, the strongest signal points to coagulation and complement activity as the core theme.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007586","count":5},{"id":"GO:0045944","count":4},{"id":"GO:0051919","count":4},{"id":"GO:0014068","count":4},{"id":"GO:0006958","count":4}]},{"hash":"964717361465075987","title":"Methyltransferase Cluster","description":"Top GO terms indicate a tight group of methyltransferase activities, including RNA methylation (rRNA, tRNA, guanine-N7) and multiple protein methylations (N-terminal, peptidyl-lysine, peptidyl-arginine). Additional links to cobalamin and antibiotic biosynthesis imply methylation steps are central to these biosynthetic processes. The strong enrichment for methylation-related functions and the dense interaction network justify labeling this as a methyltransferase-focused cluster.","confidence":"High","size":21,"edges":99,"triangles":223,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0031167","count":12},{"id":"GO:0030488","count":12},{"id":"GO:0009236","count":12},{"id":"GO:0017000","count":11},{"id":"GO:0036265","count":10}]},{"hash":"2038156615072921386","title":"Lymphocyte activation and signaling","description":"The cluster shows enrichment for immune-related signals: interleukin-4 production, B cell affinity maturation, and T cell receptor signaling, along with integrin-mediated signaling and cell migration, all pointing to lymphocyte activation and communication. Additional terms like insulin receptor signaling and Wnt pathway suggest broad signaling roles but do not override the dominant immune theme.","confidence":"High","size":21,"edges":24,"triangles":13,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043552","count":4},{"id":"GO:0032633","count":4},{"id":"GO:0002344","count":4},{"id":"GO:0008286","count":4},{"id":"GO:0016477","count":4}]},{"hash":"630836517903869055","title":"Olfactory pheromone sensing and courtship cues","description":"Top GO terms are dominated by olfactory- and pheromone-related processes (courtship behavior, olfactory behavior, detection of chemical stimuli involved in smell, detection of pheromone, sensory perception of smell). The presence of chemical cue responses such as carbon dioxide, caffeine, insecticide, L-canavanine, and bitter taste suggests a broader chemosensory module linking odor perception to behavioral responses, including mating-related cues.","confidence":"High","size":21,"edges":85,"triangles":111,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":7},{"id":"GO:0042048","count":7},{"id":"GO:0050911","count":7},{"id":"GO:0043695","count":7},{"id":"GO:0007608","count":7}]},{"hash":"1776241724607844701","title":"Membrane Transport of Ions and Metabolites","description":"The Top GO terms are dominated by various transmembrane transport activities (sodium, potassium, nitrate/nitrite, xenobiotic, vitamin transport) and related small-molecule metabolism, suggesting a cohesive function in moving ions and metabolites across membranes; this justifies a membrane-transport\u2013focused label for the cluster.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1239809179297290849","title":"Ubiquitin-Proteasome System","description":"Top GO terms indicate strong enrichment for ubiquitination events (autoubiquitination, K6- and K63-linked ubiquitination) and ubiquitin-dependent protein catabolic processes, including histone turnover. The presence of V(D)J recombination and TNF signaling terms suggests roles in immune regulation via ubiquitin ligases and chromatin remodeling. Together these point to a shared function in tagging proteins for degradation and histone turnover, i.e., the ubiquitin-proteasome system.","confidence":"High","size":20,"edges":73,"triangles":102,"max_degree":15,"top_function":"autophagy","top_go_terms":[{"id":"GO:0051865","count":12},{"id":"GO:0042787","count":11},{"id":"GO:1903265","count":11},{"id":"GO:0085020","count":11},{"id":"GO:0036205","count":11}]},{"hash":"346584582030182041","title":"Developmental cytoskeletal remodeling and adhesion","description":"The cluster is dominated by GO terms related to cytoskeletal dynamics and cell adhesion (dendritic spine morphogenesis, actin cytoskeleton reorganization, cell-matrix adhesion, substrate adhesion-dependent spreading, axon guidance) and developmental outcomes (heart development, growth hormone signaling). Immune-related terms (IL-4 production, B cell maturation) suggest signaling networks active during development, but the strongest shared theme is cytoskeletal remodeling coupled with adhesion across neuronal, cardiac, and broader developmental contexts. Confidence: High","confidence":"","size":20,"edges":110,"triangles":459,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060997","count":9},{"id":"GO:0007507","count":9},{"id":"GO:2000251","count":9},{"id":"GO:0060396","count":8},{"id":"GO:0007160","count":8}]},{"hash":"1448754020920929607","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":168,"triangles":840,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000472","count":9},{"id":"GO:0000480","count":9},{"id":"GO:0000466","count":7},{"id":"GO:0042273","count":7},{"id":"GO:0000463","count":7}]},{"hash":"127300491574129647","title":"Regulators of RTK Signaling","description":"This cluster centers on regulation of cell surface receptor tyrosine kinase signaling, including negative regulation of receptor internalization and kinase activity, and connects to development (axonogenesis, nephrogenesis) and immune pathways (TLR7 signaling, LPS response), suggesting proteins that modulate signaling outcomes rather than execute signaling.","confidence":"Medium","size":20,"edges":44,"triangles":30,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0002091","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0006469","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0072224","count":2}]},{"hash":"137559805753889258","title":"Neural Development and Chromatin Regulation","description":"Top terms point to developmental programs (multicellular organism development, brain development) with strong ties to transcriptional control and chromatin state (DNA-templated transcription; histone H3-K4 and H3-K79 methylation). While translation initiation terms indicate general expression activity, the dominant theme is gene regulation during neural development mediated by chromatin modifications, with TORC1 signaling and cholesterol metabolism providing developmental context. Confidence: High","confidence":"","size":20,"edges":34,"triangles":16,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051568","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2}]},{"hash":"1160476114506790635","title":"Gene expression regulation and cell cycle control","description":"This cluster centers on transcription-related processes (DNA-templated transcription and its regulation), translation initiation, and the SCF-dependent ubiquitin-proteasome degradation pathway, together with cell-cycle events (division and G0\u2192G1 transition) and DNA repair. The convergence of transcription, translation, proteolysis, and cell-cycle/DNA maintenance suggests a cohesive theme of gene expression control coupled to cell-cycle progression.","confidence":"Medium","size":20,"edges":86,"triangles":150,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0016032","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0031146","count":3},{"id":"GO:0006355","count":3}]},{"hash":"1949901754455444446","title":"Transcriptional Regulation of Development","description":"The top GO term is transcription by RNA polymerase II, pointing to core transcriptional control. The cluster also features several development-related terms across diverse tissues (heart, adrenal, kidney, reproductive organs, plant anther), implying a common theme: proteins involved in regulating gene expression during development across species.","confidence":"High","size":20,"edges":140,"triangles":504,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":20},{"id":"GO:0003218","count":13},{"id":"GO:0007540","count":13},{"id":"GO:0060948","count":13},{"id":"GO:0048658","count":13}]},{"hash":"1336992503449894440","title":"Developmental transcription and actin remodeling","description":"The cluster is dominated by GO terms for DNA-templated transcription and multiple developmental processes (brain, lens fiber, seminiferous tubule, multicellular organism development), plus cytoskeletal regulation (Arp2/3-mediated actin nucleation and barbed-end capping), suggesting proteins coordinating transcriptional programs with cytoskeletal remodeling during morphogenesis.","confidence":"High","size":20,"edges":111,"triangles":294,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0072520","count":5},{"id":"GO:0070306","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0000132","count":5}]},{"hash":"158482158995212611","title":"NF-kB/TNF inflammatory signaling and ubiquitination","description":"The GO terms point to NF-\u03baB activation (GO:0007250), TNF-mediated signaling (GO:0033209), and JNK pathway regulation (GO:0046328), together with ubiquitin-dependent protein catabolic processes (GO:0042787). This suggests a cohesive theme of inflammatory signaling and ubiquitin-mediated proteostasis in immune responses. The presence of immune-related terms such as V(D)J recombination and antiviral transport regulation supports an immune/inflammatory context. Overall, the cluster appears to represent inflammatory signaling tightly connected to ubiquitination.","confidence":"High","size":20,"edges":33,"triangles":18,"max_degree":7,"top_function":"autophagy","top_go_terms":[{"id":"GO:0033151","count":8},{"id":"GO:1903762","count":8},{"id":"GO:0090073","count":8},{"id":"GO:0070535","count":8},{"id":"GO:1901253","count":8}]},{"hash":"1324972333882924134","title":"Systemic Metabolic and Developmental Signaling","description":"The cluster combines metabolic processes (thiamine and folate metabolism), a starvation-response, multiple signaling activities (EGFR signaling and nitric oxide biosynthesis), cytokine production, and developmental/physiological processes (kidney development, blood pressure regulation, uterine contraction) as well as neuronal growth. This suggests a broad theme of systemic metabolic sensing and regulation of development and physiology rather than a single, narrow pathway. ","confidence":"Medium","size":20,"edges":22,"triangles":8,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042595","count":7},{"id":"GO:0010976","count":3},{"id":"GO:0009228","count":2},{"id":"GO:0046653","count":2},{"id":"GO:0045742","count":2}]},{"hash":"873836265394149130","title":"Complement and Angiogenesis in Development","description":"This cluster is driven by strong signals for both complement activation pathways (classical and lectin) and for both positive and negative regulation of angiogenesis, along with embryonic and cardiovascular development terms (in utero development, pericardium morphogenesis, osteoblast development, arterial blood pressure regulation by ANP). The combination suggests a theme centered on immune modulation of vascular and cardiac development rather than a single enzymatic function.","confidence":"Medium","size":20,"edges":7,"triangles":1,"max_degree":3,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006958","count":10},{"id":"GO:0001867","count":10},{"id":"GO:0045766","count":9},{"id":"GO:0003050","count":9},{"id":"GO:0003344","count":6}]},{"hash":"1985108904150885497","title":"Developmental Regulation and Immune Signaling","description":"The top GO terms cluster around developmental programs (exocrine pancreas development, midbrain development, post-embryonic development) and broad regulatory activity (positive regulation of transcription by RNA Pol II, regulation of cell proliferation). Immune-related terms (leukocyte tethering/rolling, regulation of chemokine production) and a glucose-response term add a regulatory/ signaling flavor with metabolic context. This suggests proteins involved in transcriptional and developmental regulation, with ancillary immune and metabolic signaling influences.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":2},{"id":"GO:0031017","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0051919","count":2},{"id":"GO:0030901","count":2}]},{"hash":"2144684380257143739","title":"Central carbon metabolism","description":"The cluster centers on core carbon-processing pathways: glycolysis, pentose phosphate pathway, the TCA cycle, glucose metabolism, and connections to acetyl-CoA formation, indicating a unified metabolism hub for energy and biosynthesis.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":8},{"id":"GO:0006096","count":7},{"id":"GO:0006098","count":6},{"id":"GO:0055114","count":6},{"id":"GO:0009228","count":5}]},{"hash":"476945721814202796","title":"Embryonic organ morphogenesis","description":"This cluster centers on diverse embryonic development and morphogenesis terms across multiple organs (heart, eye, placenta, limb, pituitary, etc.), indicating a general role in organogenesis rather than a tissue-specific pathway.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0003148","count":8},{"id":"GO:0007507","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0001890","count":7},{"id":"GO:2000288","count":7}]},{"hash":"179683291576162688","title":"Neuronal development and dendritic spine signaling","description":"The cluster is strongly enriched for nervous system development and positive regulation of dendritic spine development, complemented by small GTPase\u2013mediated signaling and regulation of protein kinase activity, pointing to roles in neuronal differentiation, synaptic formation, and cytoskeletal dynamics. A ribosomal export term appears as a general cellular process but does not override the neural-focused themes. Confidence reflects the strong alignment to neuronal development and signaling.","confidence":"High","size":20,"edges":114,"triangles":310,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007399","count":20},{"id":"GO:0000055","count":20},{"id":"GO:0060999","count":20},{"id":"GO:0034629","count":20},{"id":"GO:0046909","count":20}]},{"hash":"1876500725961155074","title":"ER organization and nuclear envelope dynamics","description":"This cluster is dominated by GO terms related to endoplasmic reticulum organization/inheritance, ER stress response, and ER tubular network organization, plus nuclear pore complex assembly and mitotic nuclear membrane reassembly, indicating a cohesive function in ER/nuclear envelope dynamics and interconnected organelle organization (with a few outlier terms likely due to broader annotations).","confidence":"High","size":20,"edges":153,"triangles":607,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0032596","count":3},{"id":"GO:0009737","count":3},{"id":"GO:0050913","count":3},{"id":"GO:0048309","count":3},{"id":"GO:0032581","count":3}]},{"hash":"2034303111365604803","title":"Unknown","description":"The GO terms are scattered across vesicle docking, neural guidance, hair follicle development, microvillus organization, GTPase regulation, sperm capacitation, secretory granule localization, brain development, centrosome maintenance, and VEGF-driven cell migration. There is no single cohesive function linking these terms, and the lack of edges suggests no tight network-wide theme, so I cannot assign a specific representative label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006904","count":2},{"id":"GO:0016198","count":2},{"id":"GO:0048820","count":2},{"id":"GO:0032529","count":2},{"id":"GO:0043087","count":2}]},{"hash":"559824394691698477","title":"Neuronal energy metabolism and membrane trafficking","description":"This cluster centers on creatine and phosphocreatine biosynthesis, suggesting neuronal energy buffering, paired with GO terms for Golgi to plasma membrane transport, and brain/cerebellum development, which together point to neuronal energy metabolism and membrane trafficking roles. Chloride ion homeostasis and phosphorylation further align with neuronal signaling and regulation, while a broader stress response indicates general cellular context. Overall, the themes cohere around brain-related energy management and membrane traffic in neurons.","confidence":"Medium","size":20,"edges":15,"triangles":3,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043001","count":2},{"id":"GO:1903955","count":2},{"id":"GO:0031468","count":2},{"id":"GO:0006600","count":1},{"id":"GO:0021549","count":1}]},{"hash":"1335326385313037840","title":"Lipid Biosynthesis and Remodeling","description":"The top GO terms cluster around lipid metabolism: triglyceride biosynthesis; phosphatidylcholine biosynthesis and remodeling; CDP-diacylglycerol biosynthesis; and PC acyl-chain remodeling, indicating a core function in lipid creation and membrane lipid remodeling. Mitochondrial ATP synthesis supports energy needs for biosynthetic processes. Immune signaling terms (IL-2 production, AICD regulation) and developmental terms (cerebellum morphogenesis, glandular epithelial maturation) are present but appear secondary or broader, so the lipid metabolism theme remains the most representative core of the cluster.","confidence":"Medium","size":20,"edges":101,"triangles":308,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":14},{"id":"GO:2001246","count":12},{"id":"GO:0010143","count":11},{"id":"GO:0021587","count":11},{"id":"GO:0002071","count":11}]},{"hash":"1708044044066777634","title":"GPCR-Rho GTPase signaling and cell migration","description":"The cluster centers on GPCR signaling (GO:0007205 and related terms), activation of GTPases and Rho signaling (GO:0090630, GO:0035023), and processes involving cell migration and adhesion (GO:0016477, GO:1900026, GO:0043314, GO:0016055). The inclusion of Wnt signaling and midbrain morphogenesis suggests developmental roles tied to cytoskeletal dynamics and movement. Together, these terms reflect a coherent theme of GPCR- and Rho-mediated signaling guiding cell migration and morphogenesis.","confidence":"High","size":20,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:1904693","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0070493","count":4}]},{"hash":"2178583667497755065","title":"Embryonic morphogenesis and extracellular matrix signaling","description":"The top GO terms cluster around developmental morphogenesis of skin, cartilage, kidney basement membrane, oviduct, and eye, with related cell adhesion and collagen-activated signaling. This suggests a common theme of tissue formation and ECM interactions during embryogenesis rather than a single specific pathway.","confidence":"Medium","size":20,"edges":2,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0032836","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0035848","count":3}]},{"hash":"1962306587670337936","title":"Bacterial envelope and polysaccharide biosynthesis","description":"The top GO terms cluster around synthesis of cell-surface and carbohydrate-related molecules (lipopolysaccharide and its core, UDP-sugar\u2013dependent biosynthesis, glycogen) and related membrane components (menaquinone), with an additional hint from antibiotic response that often accompanies envelope stress. This points to a cohesive theme of envelope-associated polysaccharide and related metabolite biosynthesis.","confidence":"High","size":20,"edges":45,"triangles":54,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006011","count":5},{"id":"GO:0006048","count":5},{"id":"GO:0005978","count":5},{"id":"GO:0046677","count":5},{"id":"GO:0009103","count":5}]},{"hash":"398656666101037823","title":"RNA processing and translation initiation","description":"The cluster shows strong enrichment for mRNA maturation and processing processes (mRNA stabilization, spliceosome assembly, splicing regulation, mRNA polyadenylation) together with components of translation initiation (eIF4F complex assembly, IRES-dependent viral translation) and regulation of RNA Pol II CTD phosphorylation, indicating a cohesive theme around RNA processing/maturation and the initiation of translation, including viral translation mechanisms.","confidence":"High","size":20,"edges":26,"triangles":15,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048255","count":8},{"id":"GO:0034462","count":8},{"id":"GO:1901407","count":8},{"id":"GO:0000381","count":8},{"id":"GO:1900363","count":8}]},{"hash":"1071305771840110515","title":"Embryonic Patterning and Organogenesis","description":"The top GO terms point to processes in early development and tissue/organ formation (left/right patterning, pancreas development, cartilage morphogenesis, trophoblast differentiation, EMT in heart formation, endocrine system development), suggesting a cohesive cluster of proteins involved in embryonic patterning and organogenesis; ubiquitin-related processes and apoptosis may reflect broader regulation but do not redefine the main theme.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4}]},{"hash":"704551753092875330","title":"Embryonic organ morphogenesis","description":"The top GO terms cluster around development and morphogenesis of multiple embryonic organs (trachea cartilage, cornea, limb bud, endocardial cushion, otic vesicle, hindgut) and vascular morphogenesis, suggesting a shared theme of embryonic organ formation. A few terms about transcription initiation and sumoylation regulation appear but do not strongly redefine the cluster\u2019s core signal. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070898","count":1},{"id":"GO:0033234","count":1},{"id":"GO:0060534","count":1},{"id":"GO:0061303","count":1},{"id":"GO:0060174","count":1}]},{"hash":"487640163067728127","title":"Ubiquitin-Mediated Protein Turnover","description":"The Top Terms are dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, negative regulation of protein ubiquitination, and K33-linked ubiquitination. While some terms touch on development or immune signaling, the strongest and most frequent annotations point to ubiquitin-regulated protein turnover as the unifying theme of this cluster. Confidence: High","confidence":"","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":6},{"id":"GO:0009638","count":5},{"id":"GO:0048294","count":5},{"id":"GO:0043380","count":5},{"id":"GO:0045497","count":5}]},{"hash":"2123190960158219697","title":"Diverse lipid and secondary metabolite biosynthesis","description":"The proteins are enriched for multiple biosynthetic processes across lipids (sphingolipid and 3-keto-sphinganine metabolism), steroids (testosterone biosynthesis), and secondary metabolites (tropane alkaloids, antibiotics), plus related vitamin K1 metabolism. This points to a broad theme of biosynthesis of diverse metabolites rather than a single, cohesive pathway, justifying a label focused on lipid and secondary metabolite biosynthesis. Some terms appear noise (e.g., lung development, obsolete processes) but do not define the cluster\u2019s core function.","confidence":"Medium","size":20,"edges":171,"triangles":969,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":20},{"id":"GO:0006666","count":19},{"id":"GO:0042619","count":19},{"id":"GO:0042376","count":19},{"id":"GO:0009710","count":19}]},{"hash":"1860538576830425417","title":"Drosophila eye and antenna development","description":"The GO terms show strong signals for compound eye development and antennal development, suggesting the proteins participate in sensory organ patterning in Drosophila. Additional terms point to regulatory processes (protein tetramerization, miRNA-mediated gene silencing) and growth/stress responses (epithelial proliferation regulation, apoptosis under osmotic stress, hypoxia), which may reflect broader developmental regulation and stress response mechanisms associated with sensory organ formation. Overall, the cluster best fits a developmental sensory organ theme with supporting regulatory roles.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0050680","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0051092","count":2}]},{"hash":"1333428947904707886","title":"Neural development and ER organization","description":"The terms point to neuronal development processes (axon fasciculation, guidance, and migration) while also highlighting endoplasmic reticulum tubular network organization and nuclear pore assembly, suggesting a cluster of proteins involved in neural development with ER/nuclear pore\u2013related functions.","confidence":"Medium","size":20,"edges":185,"triangles":1055,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0071788","count":2},{"id":"GO:0060317","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0032581","count":2},{"id":"GO:2000172","count":2}]},{"hash":"41610755958941664","title":"Immune development and epigenetic regulation","description":"The terms cluster around immune system processes such as V(D)J recombination and regulation of germinal centers, combined with chromatin-level regulation like X chromosome inactivation and histone/ubiquitination, suggesting a theme of immune development coupled with epigenetic control. Some terms appear more unrelated noise, preventing a narrower specific function.","confidence":"Medium","size":20,"edges":14,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060816","count":2},{"id":"GO:0002635","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0033151","count":2},{"id":"GO:1903762","count":2}]},{"hash":"227291265230573728","title":"Embryonic patterning and organogenesis","description":"The cluster centers on developmental processes across multiple lineages\u2014left/right patterning, pancreatic endocrine development, cartilage formation, placental trophoblast differentiation, and EMT in heart development\u2014pointing to a cohesive theme of embryogenesis and organ formation. An outlier term related to insect hormone biosynthesis stands out but does not negate the overall pattern. ","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":4},{"id":"GO:0003323","count":4},{"id":"GO:0060536","count":4},{"id":"GO:0060707","count":4},{"id":"GO:0003198","count":4}]},{"hash":"792814833331566546","title":"Neural development and synaptic signaling","description":"The enriched terms cluster around nervous system development, axon guidance, and synaptic regulation, including ionotropic glutamate receptor signaling and regulation of synapse structure or activity, indicating a cohesive theme of neural development and synaptic function. Some terms (amyloid fibril formation, endopeptidase regulation, placental morphogenesis) are less central noise, but do not override the dominant neural-focused signals.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:1990000","count":2},{"id":"GO:0048669","count":2},{"id":"GO:0035235","count":2},{"id":"GO:0060670","count":2}]},{"hash":"1582632939989489296","title":"Chemosensory signaling and environmental stress response","description":"The top GO terms point to chemosensation (pheromone response, smell perception) and social behavior as central themes, suggesting a core role in chemical cue detection and related behavior. The presence of stress-related terms (heat, UV, cold acclimation, starvation) indicates these proteins also participate in environmental response. Together, this suggests a cluster centered on chemosensory signaling with broader environmental responsiveness, though the mix of terms (including obsolete ones) implies partial or indirect connections rather than a single, cohesive function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0018298","count":2}]},{"hash":"775443919273028492","title":"Membrane trafficking and glycosylation","description":"The set includes dolichol-linked oligosaccharide biosynthesis (glycosylation), endosome-to-vacuole transport, regulation of protein localization to the cell surface, and glucose transport, which together point to membrane trafficking and membrane-associated metabolism. Some terms (pheromone detection, grooming behavior, lens development) are organism-specific and less tied to trafficking, but the core signals reflect vesicular transport and glycosylation pathways.","confidence":"Medium","size":20,"edges":51,"triangles":17,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006488","count":2},{"id":"GO:2000009","count":1},{"id":"GO:0032511","count":1},{"id":"GO:0060400","count":1},{"id":"GO:0043695","count":1}]},{"hash":"777461314420391873","title":"Retina Photoreceptor Development and Maintenance","description":"This cluster is dominated by terms related to photoreceptor biology and retina development, including camera-type eye photoreceptor cell differentiation and photoreceptor cell maintenance. Neural-related terms like filopodium assembly, receptor clustering, and long-term synaptic depression also fit retinal neuron synaptic function, suggesting a retina-focused, neuronal differentiation theme. A few terms about podocyte and glomerular epithelial differentiation appear less central to the main theme.","confidence":"Medium","size":20,"edges":51,"triangles":61,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":5},{"id":"GO:0043113","count":3},{"id":"GO:0060292","count":3},{"id":"GO:0035176","count":3},{"id":"GO:0070830","count":3}]},{"hash":"747577651964283301","title":"Flavonoid Biosynthesis and Lignin Metabolism","description":"This cluster is dominated by GO terms tied to flavonoid biosynthesis, including anthocyanin-, kaempferol-, quercetin-, and cyanidin-based compound biosynthetic processes, plus related glucuronidation and genistein responses, and a lignin metabolic process. Together these point to a cohesive theme of phenylpropanoid-derived secondary metabolism, particularly flavonoids and lignin biosynthesis, with some xenobiotic/estrogen-related terms likely reflecting broader metabolic connections or annotation artifacts.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":20},{"id":"GO:0033330","count":20},{"id":"GO:0009808","count":20},{"id":"GO:0052697","count":20},{"id":"GO:0016999","count":20}]},{"hash":"264970801649012309","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":3},{"id":"GO:0034051","count":3},{"id":"GO:0042771","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0042347","count":3}]},{"hash":"1684984745998802260","title":"Actin Cytoskeleton Remodeling and Lamellipodium Assembly","description":"The cluster is driven by GO terms for Rho/GTPase signaling, lamellipodium and microspike formation, and actin cytoskeleton reorganization, indicating a shared role in actin dynamics and cell motility. Immune pathway terms are present but secondary.","confidence":"High","size":20,"edges":26,"triangles":7,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":5},{"id":"GO:0035023","count":5},{"id":"GO:0030032","count":5},{"id":"GO:0030035","count":4},{"id":"GO:0050853","count":4}]},{"hash":"506263749795266478","title":"Embryonic organogenesis","description":"The top GO terms center on developmental processes across diverse organs (eye, pancreas, lung, nervous system, muscle, inner ear) and general multicellular development, indicating embryonic organogenesis as the unifying theme, with RNA polymerase II\u2013mediated transcription reflecting active program regulation.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0048048","count":13},{"id":"GO:0043010","count":13},{"id":"GO:0031018","count":13},{"id":"GO:0060441","count":13}]},{"hash":"1733931061699686542","title":"Collagen maturation and ECM remodeling with angiogenesis","description":"Key signals are collagen-related: peptidyl-proline hydroxylation to 4-hydroxy-L-proline and collagen fibril organization, indicating collagen maturation. Angiogenesis is also represented, fitting with ECM remodeling that supports new blood vessel formation. Some terms seem noise (obsolete, neural), but the strongest link is ECM/collagen modification driving angiogenesis.","confidence":"High","size":20,"edges":18,"triangles":5,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0032504","count":4},{"id":"GO:0008355","count":3},{"id":"GO:0010226","count":3},{"id":"GO:0032364","count":3}]},{"hash":"1083117488515636018","title":"Olfactory and Pheromone Detection","description":"Most of the top GO terms center on olfactory perception and chemosensory behavior (smell, olfactory behavior, pheromone detection, detection of chemical stimuli involved in smell, CO2 detection). A few terms mention responses to specific chemicals (caffeine, insecticide) but still fall under chemical-sensing pathways. This suggests the cluster represents a chemosensory/olfactory module focused on odor and pheromone detection.","confidence":"High","size":20,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007608","count":5},{"id":"GO:0007619","count":4},{"id":"GO:0042048","count":4},{"id":"GO:0050911","count":4},{"id":"GO:0043695","count":4}]},{"hash":"128219170246264484","title":"Neuro-muscular development and signaling","description":"The top GO terms center on nervous system development, nerve impulse transmission, axon protein localization, and muscle differentiation/assembly, with some adhesion terms; together they point to coordinated neural and muscular development and signaling processes, despite a few unrelated developmental terms.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0060168","count":9},{"id":"GO:0001822","count":9},{"id":"GO:0007432","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0034164","count":9}]},{"hash":"1719500318452406320","title":"Membrane Transport of Ions, Sugars, and Neurotransmitters","description":"The top GO terms cluster around transmembrane transport for a variety of substrates\u2014sodium ions, nitrates/nitrites, galactose, fucose, vitamins, xenobiotics, and even neurotransmitter loading into synaptic vesicles\u2014pointing to transporter or membrane-transport roles as the common theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2},{"id":"GO:0006004","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0035725","count":2}]},{"hash":"292590274580791699","title":"Chromatin modification and transcriptional regulation","description":"This cluster centers on histone modifications (H3K27, H3K4 methylation/dimethylation, acetylation), nucleosome assembly, and repression of RNA Pol II transcription, pointing to epigenetic control of gene expression. Developmental terms like heart development and placenta morphogenesis suggest these chromatin regulators guide developmental programs. Overall, it likely comprises chromatin-modifying enzymes and transcriptional regulators coordinating gene expression during development.","confidence":"High","size":19,"edges":64,"triangles":81,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":4},{"id":"GO:0098532","count":3},{"id":"GO:2001040","count":3},{"id":"GO:0080182","count":3},{"id":"GO:0060669","count":3}]},{"hash":"1539310148157738534","title":"Chromatin Organization and Mitotic Cell Cycle","description":"This cluster's top terms center on nuclear processes: chromatin assembly and modification (CENP-A assembly, H3-K9 methylation), DNA-templated transcription, and cell-cycle/mitotic progression (cell division, mitotic cell cycle, SCF-dependent proteasomal degradation), with microtubule severing highlighting cytoskeletal dynamics. A vesicle trafficking term appears but is not the dominant theme, so the primary signal is chromatin regulation linked to mitosis.","confidence":"High","size":19,"edges":116,"triangles":333,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0051567","count":4},{"id":"GO:0061641","count":4},{"id":"GO:0006349","count":4}]},{"hash":"2174195493544277274","title":"Developmental transcription and chromatin assembly","description":"The cluster centers on DNA-templated transcription and CENP-A\u2013containing chromatin assembly, with supporting signals for cell division and multicellular development (skeletal system and organismal development). Additional terms point to cytoskeletal dynamics and vesicle trafficking, which often accompany chromatin remodeling and developmental processes, suggesting a cohesive theme of transcriptional/chromatin regulation intertwined with development.","confidence":"High","size":19,"edges":56,"triangles":42,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0051013","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0051301","count":5}]},{"hash":"1470289555364599438","title":"Ribosome biogenesis and translational control","description":"The cluster centers on translation initiation and regulation (reinitiation, preinitiation complex formation, miRNA-mediated silencing) and includes small-subunit processome assembly, indicating ribosome biogenesis, mRNA stability, and broader RNA processing. Together these terms point to post-transcriptional control of gene expression at the level of translation and ribosome assembly.","confidence":"High","size":19,"edges":48,"triangles":35,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0035278","count":5},{"id":"GO:0048255","count":4},{"id":"GO:0034462","count":4}]},{"hash":"1793816701704253113","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":87,"triangles":212,"max_degree":17,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":5},{"id":"GO:0009442","count":4},{"id":"GO:0019557","count":4},{"id":"GO:0051491","count":4},{"id":"GO:1904530","count":4}]},{"hash":"1493449235639098934","title":"Ribosome Biogenesis and Translation","description":"The GO terms cluster around protein synthesis and ribosome assembly: translation, ribosome biogenesis, translational initiation, and formation of the translation preinitiation complex, supported by rRNA maturation and ITS1 processing events. While a few terms touch on cell division and fertilization, the dominant signal is ribosome biogenesis and translation machinery, making this a coherent functional group. ","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":11},{"id":"GO:0042254","count":8},{"id":"GO:0051301","count":4},{"id":"GO:0006413","count":4},{"id":"GO:0000462","count":3}]},{"hash":"971102515826436420","title":"DNA Repair and Stress Response","description":"This cluster is enriched for base-excision repair and DNA repair terms, along with apoptotic process and cellular responses to xenobiotic and hormone stimuli, suggesting a module where DNA damage sensing/repair links to stress-induced apoptosis and broader cellular stress responses.","confidence":"High","size":19,"edges":130,"triangles":470,"max_degree":18,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0006284","count":7},{"id":"GO:0007568","count":6},{"id":"GO:0042493","count":6},{"id":"GO:0006915","count":6},{"id":"GO:0000289","count":5}]},{"hash":"586422767133098072","title":"Unknown","description":"The terms show a mix of cytoskeletal/podosome assembly, RNA processing/splicing, innate immune signaling, and DNA-centric processes (transformation competence, plasmid maintenance, DNA replication). There isn\u2019t a clear, cohesive function tying most proteins together, suggesting no single representative theme for this cluster.","confidence":"","size":19,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071800","count":2},{"id":"GO:0006397","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0009870","count":1}]},{"hash":"1095947096994101084","title":"Differentiation Signaling and Transcription Regulation","description":"The top GO terms point to nuclear receptor signaling (retinoic acid receptor) and SMAD/TGF-beta pathways, along with differentiation outcomes (pneumocyte and osteoblast differentiation). Coupled with transcription-related terms (miRNA transcription, histone deacetylation regulation) and stress-responsive processes (unfolded protein response), the cluster seems to group proteins involved in signaling cues that drive development and tightly regulate gene expression. The cross-tunch of terms across tissues suggests a general differentiation/ transcriptional control module rather than a single tissue-specific function.","confidence":"Medium","size":19,"edges":143,"triangles":675,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0048384","count":4},{"id":"GO:0060509","count":4},{"id":"GO:0045475","count":3},{"id":"GO:0009737","count":3},{"id":"GO:0060395","count":3}]},{"hash":"676327155053364061","title":"Multi-tissue Development and Ubiquitination Regulation","description":"The top GO terms point to developmental processes across several tissues (skeletal muscle development/tissue development, nervous system development, distal tubule morphogenesis, and renal sodium absorption) as well as circadian rhythm and synaptic vesicle endocytosis. Two ubiquitination-related terms (negative regulation of protein ubiquitination and K33-linked ubiquitination) suggest a shared regulatory layer. Together, these indicate a cluster of proteins involved in broad developmental programs across multiple tissues, potentially governed by ubiquitination pathways. Confidence in this cross-tissue, development-focused label is Medium.","confidence":"Medium","size":19,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0048741","count":3},{"id":"GO:0042748","count":3},{"id":"GO:0031397","count":3},{"id":"GO:1900242","count":3},{"id":"GO:0072156","count":3}]},{"hash":"1567842513931075666","title":"Heart Development and Calcium Signaling","description":"This cluster centers on cardiac formation and function, with GO terms tied to heart development, ventricular morphogenesis, and cardiac muscle contraction, and it includes regulation of calcium handling via ryanodine receptor activity, linking to excitation-contraction coupling. The presence of intracellular signal transduction and related inflammatory signaling terms suggests a broader but heart-focused signaling module that supports development, contraction, and Ca2+ dynamics.","confidence":"High","size":19,"edges":25,"triangles":11,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0032088","count":2},{"id":"GO:0055010","count":2},{"id":"GO:0060315","count":2},{"id":"GO:0070301","count":2},{"id":"GO:0035556","count":2}]},{"hash":"230473880817861102","title":"Developmental and sensory systems with immune signaling","description":"This cluster\u2019s GO terms center on development of multiple tissues (pharyngeal system, ear, kidney) and sensory processes (pain perception, olfactory learning), with immune/inflammatory components (leukocyte migration, cytokine response) and stress-related responses (UV-B, replicative senescence). Substance P catabolic process links to pain signaling. The pattern suggests a broad theme of developmental and sensory functions paired with immune signaling, rather than a single, cohesive pathway.","confidence":"Medium","size":19,"edges":10,"triangles":2,"max_degree":7,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0060037","count":4},{"id":"GO:0019233","count":4},{"id":"GO:0002523","count":3},{"id":"GO:0043583","count":3},{"id":"GO:0001822","count":3}]},{"hash":"2220421314591001812","title":"Cellular redox homeostasis and oxidative stress response","description":"This cluster centers on maintaining redox balance and detoxifying reactive species, as indicated by terms for cellular redox homeostasis, oxidation\u2013reduction processes, and cellular response to oxidative stress. Additional terms point to redox-regulated proteostasis, including protein deglutathionylation and ER protein folding, suggesting a cohesive role in protecting cells from oxidative damage and managing redox-linked protein processing.","confidence":"High","size":19,"edges":163,"triangles":845,"max_degree":18,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":19},{"id":"GO:0055114","count":17},{"id":"GO:0098869","count":17},{"id":"GO:1903206","count":16},{"id":"GO:0006662","count":16}]},{"hash":"125533072479239267","title":"Chromatin modification and differentiation regulation","description":"These proteins show enrichment for histone demethylation (H3K4, H3K36) and related chromatin modification, tied to DNA-templated transcription. Additional terms relate to regulation of differentiation (myoblast/osteoblast) and signaling pathways (Notch) affecting vasculogenesis. Together, they point to chromatin-modifying factors that govern transcription and developmental differentiation, justifying a label centered on chromatin modification and differentiation control.","confidence":"High","size":19,"edges":6,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034720","count":2},{"id":"GO:0045668","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0030961","count":1},{"id":"GO:0070544","count":1}]},{"hash":"1507073495059322155","title":"Mitosis and Chromatin Regulation in Development","description":"Top GO terms are dominated by mitotic processes (cohesion, chromosome segregation, mitotic DNA replication) and chromatin regulation (histone methylation, protein ubiquitination), with supportive signals from TGF-beta response and growth/development terms. This suggests a cluster of proteins that coordinate cell division with chromatin state and developmental signaling in multicellular contexts, especially forebrain development. ","confidence":"Medium","size":19,"edges":27,"triangles":14,"max_degree":8,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0071560","count":15},{"id":"GO:0043547","count":15},{"id":"GO:0050731","count":15},{"id":"GO:0030900","count":12},{"id":"GO:0035264","count":12}]},{"hash":"795280246412788413","title":"Sugar catabolism and nucleotide salvage","description":"The cluster is enriched for carbohydrate metabolism terms (tagatose-6-phosphate/Lactose pathway, ribose, fructose, sucrose, carbohydrate phosphorylation) and nucleotide salvage/biosynthesis (adenosine salvage, AMP salvage, dATP biosynthetic). This pattern suggests a cohesive group of enzymes handling sugar catabolism alongside nucleotide salvage and related biosynthesis, justifying the label.","confidence":"High","size":19,"edges":155,"triangles":761,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0046835","count":6},{"id":"GO:0006169","count":5},{"id":"GO:2001059","count":5},{"id":"GO:0009750","count":5},{"id":"GO:0019303","count":5}]},{"hash":"1714295151142474736","title":"Sphingolipid metabolism and adipogenesis","description":"The top GO terms cluster around lipid biology, especially sphingolipid metabolism (sphingosine and sphinganine pathways) and fatty acid\u2013related processes, including white fat cell differentiation. While some terms are obsolete or context-specific (e.g., tarsal gland development in insects), the dominant theme ties to lipid biosynthesis and adipogenic differentiation, suggesting this cluster reflects sphingolipid metabolism linked to adipogenesis. Confidence: High","confidence":"","size":19,"edges":152,"triangles":717,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0010205","count":10},{"id":"GO:1903699","count":10},{"id":"GO:0010873","count":10},{"id":"GO:0046512","count":10},{"id":"GO:0070542","count":10}]},{"hash":"1763096057265867087","title":"Translation Machinery and mRNA Decay","description":"The dominant GO terms center on core and regulatory aspects of protein synthesis\u2014translation in general, initiation, elongation, termination, and even selenocysteine incorporation\u2014along with RNA turnover via deadenylation-dependent decay and related RNA regulation. A few outliers (e.g., glial proliferation) are less representative, so the overall theme is translation and post-transcriptional RNA control.","confidence":"High","size":19,"edges":153,"triangles":816,"max_degree":17,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0046677","count":10},{"id":"GO:0006413","count":10},{"id":"GO:0000288","count":10},{"id":"GO:0001514","count":10}]},{"hash":"1130323489869733194","title":"Glycinergic neurotransmission and amino acid transport","description":"The cluster is enriched for glycine-related processes (glycine import, secretion, and glycinergic synaptic transmission) and for general amino acid transport (leucine, proline, taurine), indicating a module focused on amino acid handling at synapses. The presence of dopamine catabolic process and serotonin uptake suggests this cluster also intersects monoaminergic neurotransmission, but the dominant theme is glycinergic signaling and amino acid transport.","confidence":"Medium","size":19,"edges":33,"triangles":16,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":15},{"id":"GO:0051610","count":15},{"id":"GO:0061537","count":15},{"id":"GO:1905847","count":15},{"id":"GO:0021984","count":15}]},{"hash":"1998325099521327513","title":"Chemosensory and mechanosensory signaling with ion homeostasis","description":"We infer a sensory-focused cluster because many top terms point to detection of chemical cues (pheromone), mechanosensory processes and regulation of synaptic activity, and ionic balance via sodium transport/homeostasis. Some terms like face morphogenesis may be less related or noisy, but the prevailing theme is sensory perception and neuronal signaling coupled with ion regulation. ","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":6},{"id":"GO:0060325","count":3},{"id":"GO:0043066","count":1},{"id":"GO:0060025","count":1},{"id":"GO:0055078","count":1}]},{"hash":"935543611194664693","title":"Microtubule-based transport and cytoskeleton regulation","description":"The cluster\u2019s top GO terms center on microtubule-dependent movement and intracellular transport, with supporting signals from cytoskeleton regulation and related processes (neuron projection morphogenesis, spermatid development). The combination suggests proteins that coordinate transport along microtubules and regulate the cytoskeleton, with ancillary involvement in mitochondrial import and development in specialized cell types.","confidence":"Medium","size":19,"edges":44,"triangles":33,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":2},{"id":"GO:0046944","count":2},{"id":"GO:0007286","count":2},{"id":"GO:0050821","count":1},{"id":"GO:0075521","count":1}]},{"hash":"2063639317340749435","title":"Xenobiotic and lipid transporters","description":"The terms center on transport of drugs and xenobiotics (daunorubicin, doxorubicin, xenobiotic export) and lipid-related processes (lipoprotein transport, long-chain fatty acid import into peroxisomes, cholesterol/phytosterol absorption regulation), indicating a cluster of membrane transport proteins involved in detoxification and lipid metabolism.","confidence":"High","size":19,"edges":50,"triangles":65,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0043215","count":11},{"id":"GO:0045796","count":11},{"id":"GO:0006855","count":11},{"id":"GO:1900753","count":11},{"id":"GO:0010949","count":11}]},{"hash":"600726193833420572","title":"Exocytosis and Golgi vesicle trafficking","description":"The cluster\u2019s top GO terms center on exocytosis, vesicle tethering to the plasma membrane, Golgi organization, and Golgi-to-plasma membrane transport, with exocyst localization/assembly and related protein transport, plus Rho signaling. This strongly supports a cohesive role in Golgi-to-plasma membrane vesicle trafficking and exocytosis, likely exocyst-mediated; a few outlier terms (meiosis cytokinesis) do not override the main theme.","confidence":"High","size":19,"edges":82,"triangles":164,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0090522","count":4},{"id":"GO:0006887","count":4},{"id":"GO:0007030","count":4},{"id":"GO:0006893","count":3},{"id":"GO:0051601","count":3}]},{"hash":"1448115759602083716","title":"Methionine salvage and threonine biosynthesis","description":"Based on the top GO terms, the cluster is enriched for methionine salvage from MTA/SAH and L-threonine biosynthesis, pointing to amino acid metabolism as the central theme. Additional links to choline/phospholipid biosynthesis and general phosphorylation are present but less prominent, suggesting these proteins may have broader roles beyond core metabolism. Overall, the cluster most consistently reflects amino acid metabolism, especially methionine salvage and threonine production.","confidence":"Medium","size":19,"edges":43,"triangles":54,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":14},{"id":"GO:0046677","count":14},{"id":"GO:0009088","count":14},{"id":"GO:0019284","count":14},{"id":"GO:0016310","count":14}]},{"hash":"1681509220702263715","title":"Unknown","description":"The terms are a mix of inflammatory signaling (TNF/NF-kB, LPS response), apoptotic signaling, and unrelated processes (ion transport, proton motive force-driven ATP synthesis, snoRNA localization, plant hypersensitive response, heart looping). With only a single edge and no cohesive functional theme, there is no clear common function tying the proteins together, so an Unknown label is most appropriate.","confidence":"","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":1},{"id":"GO:0034051","count":1},{"id":"GO:0042771","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0042347","count":1}]},{"hash":"1680015127026522248","title":"Signaling and sensory-response pathways","description":"The terms show diverse signaling and stimulus-response themes, including Wnt signaling, calcium release, thermo- and nociceptive detection, cold and mechanical stimuli, and ubiquitination. Since no single dominant process stands out, the label reflects general signaling and sensory-response functions rather than a specific pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0051209","count":2},{"id":"GO:1904908","count":2},{"id":"GO:0050968","count":2},{"id":"GO:0009409","count":2}]},{"hash":"415216796798605796","title":"Cytoskeletal dynamics and cell division","description":"The top GO terms cluster around actin-based movement, mitotic actomyosin contractile ring assembly, and microtubule minus-end localization, plus regulation of GTPase activity and cell spreading/adhesion. This points to a cohesive theme of cytoskeletal remodeling during cell division and motility, with a few outlier terms that are less representative. ","confidence":"High","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0003025","count":2},{"id":"GO:1904519","count":2},{"id":"GO:0050765","count":2},{"id":"GO:1903475","count":2},{"id":"GO:0030048","count":2}]},{"hash":"67683304542534812","title":"Neuronal development and synaptic signaling regulation","description":"The cluster is dominated by terms tied to brain development and synaptic function, including brain development, regulation of synaptic vesicle exocytosis, and short-term synaptic potentiation, suggesting that the proteins jointly influence neuronal development and synaptic transmission. Additional terms about GTPase activity and Ras signaling indicate broader signal-regulation roles that often accompany synaptic processes. Some outliers (e.g., mating projection growth, plant ABA signaling) may reflect annotation breadth or species-specific contexts, but the core theme centers on neuronal development and synaptic regulation.","confidence":"High","size":19,"edges":51,"triangles":34,"max_degree":9,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0010796","count":7},{"id":"GO:0007420","count":7},{"id":"GO:0031384","count":7},{"id":"GO:2000300","count":7},{"id":"GO:0009738","count":7}]},{"hash":"431614409954602284","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":83,"triangles":174,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":7},{"id":"GO:0030206","count":7},{"id":"GO:0006477","count":6},{"id":"GO:0050427","count":6},{"id":"GO:0015012","count":6}]},{"hash":"1982139974131536660","title":"Developmental Signaling and Immune Maturation","description":"The proteins cluster around multiple signaling pathways (insulin receptor, ephrin receptor, Wnt, PI3K-Akt) and developmental processes (neural tube closure, heart development), along with immune differentiation (IL-4 production, hematopoiesis, B cell maturation). This suggests a cohesive theme of signaling networks governing embryonic development and immune cell maturation. ","confidence":"Medium","size":19,"edges":90,"triangles":182,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008286","count":7},{"id":"GO:0048013","count":6},{"id":"GO:0090263","count":6},{"id":"GO:0043491","count":6},{"id":"GO:0032633","count":6}]},{"hash":"664205344718361268","title":"Proteoglycan Biosynthesis and ECM Development","description":"The terms cluster around biosynthesis and metabolism of proteoglycans (heparan sulfate, dermatan sulfate, chondroitin sulfate), their localization, and related developmental processes (chondrocyte development, ureteric bud formation), pointing to extracellular matrix proteoglycans as the shared theme. A few terms like maltose transport are incidental outliers, but the dominant signal is proteoglycan-related ECM biology.","confidence":"High","size":19,"edges":53,"triangles":43,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":4},{"id":"GO:0030202","count":4},{"id":"GO:0033037","count":4},{"id":"GO:0015014","count":4},{"id":"GO:0015015","count":4}]},{"hash":"1960577445815246295","title":"Actin Remodeling and Cell Migration","description":"The cluster is dominated by terms for lamellipodium assembly, cell migration, and Rho-mediated signal transduction, all pointing to actin cytoskeleton remodeling driving movement. Additional terms for GPCR/thrombin receptor signaling and synaptic components (postsynaptic density, vesicle priming) suggest broader signaling roles that can modulate cytoskeletal dynamics. Overall, the core theme is cytoskeletal remodeling enabling migration, with related signaling contexts. ","confidence":"High","size":19,"edges":10,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007205","count":8},{"id":"GO:0016477","count":7},{"id":"GO:0030032","count":6},{"id":"GO:0031666","count":5},{"id":"GO:0070493","count":5}]},{"hash":"2255520064277439883","title":"Egg Activation and Chorion Formation","description":"These terms cluster around oocyte and early embryo development: egg activation, vitelline membrane/chorion-containing eggshell formation, and calcium-dependent signaling via the calcineurin-NFAT pathway. The convergence on egg development and a calcium-triggered activation pathway suggests a cohesive role for these proteins in preparing and activating the egg for fertilization and early embryogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007343","count":1},{"id":"GO:0007305","count":1},{"id":"GO:0051533","count":1}]},{"hash":"1017454174878216648","title":"Mitochondrial ATP Synthesis and Proton Transport","description":"This cluster is dominated by GO terms related to proton motive force-driven ATP synthesis, proton transmembrane transport, vacuolar acidification, and sodium transport, pointing to a core theme of energy metabolism and ion homeostasis across membranes. Some terms (transcription termination, lipid metabolism, angiogenesis, proteasome granule assembly) are less directly tied and may reflect annotation noise or multifunctional proteins, but the strongest signal is mitochondrial energy production and proton transport.","confidence":"High","size":19,"edges":158,"triangles":791,"max_degree":18,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042777","count":11},{"id":"GO:0006626","count":10},{"id":"GO:0007035","count":10},{"id":"GO:0006814","count":10},{"id":"GO:0015991","count":10}]},{"hash":"337164631627579755","title":"Immune Response and Developmental Regulation","description":"The top GO terms repeatedly highlight immune-related processes (defense against fungus, leukocyte tethering/rolling, chemokine production) alongside developmental and transcription-regulation terms (pancreas and midbrain development, post-embryonic development, RNA polymerase II transcription regulation). This suggests a cluster of proteins involved in immune signaling with broader developmental and gene-expression regulatory roles, rather than a single tight pathway.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":11},{"id":"GO:0045944","count":10},{"id":"GO:0031017","count":10},{"id":"GO:1903238","count":10},{"id":"GO:0051919","count":10}]},{"hash":"1069676388676668045","title":"Unknown","description":"The terms cover development (ureteric bud, BMP signaling), vascular processes (endothelial activation/differentiation), sensory aspects (sound perception, otolith tethering), and metabolism, showing no clear, shared function among the proteins.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":3},{"id":"GO:0001657","count":2},{"id":"GO:0035889","count":2},{"id":"GO:0042118","count":2},{"id":"GO:0008344","count":2}]},{"hash":"1018985584097364354","title":"Regulated Signaling and Vesicle Exocytosis","description":"The cluster centers on terms related to signaling pathway regulation and vesicle trafficking, including ABA-activated signaling, regulation of synaptic vesicle exocytosis, short-term synaptic potentiation, and multivesicular body size. While some terms come from different organisms and contexts (plants, neural tissue, yeast), the shared theme appears to be the regulation of signaling and vesicle dynamics across systems.","confidence":"Medium","size":19,"edges":88,"triangles":173,"max_degree":16,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0009738","count":13},{"id":"GO:0010796","count":11},{"id":"GO:0007420","count":11},{"id":"GO:0031384","count":11},{"id":"GO:2000300","count":11}]},{"hash":"280071536692959645","title":"Ubiquitin-Dependent Signaling and Transcription Regulation","description":"The top GO terms cluster around ubiquitin-related processes (negative regulation of ubiquitination, ubiquitin-dependent endocytosis, proteasome-mediated degradation) and signaling/transcription control (ERK cascade, Rho signaling, dopaminergic synaptic transmission, and transcription by RNA Pol II). This suggests a module where protein turnover via ubiquitination and proteasome activity intersects with signaling pathways and gene regulation. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0070086","count":3},{"id":"GO:0032226","count":2},{"id":"GO:0045944","count":2}]},{"hash":"2207946307012039259","title":"Unknown","description":"The GO terms are diverse and disconnected: heart development and sarcomere organization hint at cardiac muscle function, while inflammatory mediator production and chemokine regulation point to immune signaling; other terms include chitin catabolism, mast cell degranulation, sperm axoneme assembly, and general metabolic processes. No single coherent function links the cluster, so Unknown with None confidence.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":1},{"id":"GO:0045214","count":1},{"id":"GO:0061049","count":1},{"id":"GO:0002532","count":1},{"id":"GO:0005975","count":1}]},{"hash":"89589276605144547","title":"Drosophila development and morphogenesis","description":"The top GO terms cluster around embryonic morphogenetic processes (dorsal closure, centrosome cycle, germline ring canal formation) and imaginal disc development (wing hair organization, compound eye photoreceptor development), with supporting terms for cellular regulation (protein dephosphorylation, nucleocytoplasmic transport) and broader cellular responses. This pattern strongly points to developmental and morphogenetic roles in Drosophila, though some terms are more general cell biology. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035508","count":2},{"id":"GO:0035690","count":2},{"id":"GO:0030725","count":2},{"id":"GO:0007098","count":2},{"id":"GO:0007391","count":2}]},{"hash":"1752748513341232938","title":"Rho/Ras GTPase signaling and cell polarity in development","description":"The cluster\u2019s top GO terms center on small GTPase signaling (Rho, Ras, general small GTPase activity) and regulation of cell polarity, with notable developmental terms (heart, spinal cord, placenta development) suggesting a module where GTPase-driven polarity processes coordinate development. A few other terms (DNA-templated transcription, phosphatase activity regulation) are supportive but do not override the core GTPase/polarity theme.","confidence":"High","size":19,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2000114","count":3},{"id":"GO:0010923","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0021510","count":2}]},{"hash":"1263634597476556805","title":"Mitochondrial import and lipid signaling in development","description":"The terms emphasize mitochondrial-related processes (protein import into mitochondrial matrix; regulation of mitochondrial membrane permeability) alongside lipid metabolism/signaling (triglyceride biosynthesis; phosphatidylinositol dephosphorylation; phosphatidate phosphatase activity), with developmental and cell-cycle cues (mesoderm development; connective tissue replacement; meiotic checkpoint signaling). This suggests a theme where mitochondrial function intersects lipid signaling to influence development and proliferation. ","confidence":"Medium","size":19,"edges":42,"triangles":37,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0070940","count":7},{"id":"GO:0046902","count":4},{"id":"GO:2000134","count":4},{"id":"GO:0010867","count":4},{"id":"GO:1903740","count":4}]},{"hash":"1630556332100781284","title":"Blood Coagulation and Fibrinolysis","description":"Most frequent GO terms are fibrinolysis and blood coagulation (16 each), indicating a core theme of hemostasis. Additional terms cover regulation of fibrinolysis and various developmental processes, suggesting broader roles in growth and tissue development, but the dominant signature is coagulation/fibrinolysis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":16},{"id":"GO:0071333","count":16},{"id":"GO:0007596","count":16},{"id":"GO:0045944","count":15},{"id":"GO:0031017","count":15}]},{"hash":"1785595680813553881","title":"Renal-vascular inflammatory and metabolic regulation","description":"The top GO terms point to kidney development and blood pressure regulation, together with NO biosynthesis (vascular tone), inflammatory responses (lipopolysaccharide response, cytokine production), plus cholesterol homeostasis, gluconeogenesis, and apoptosis. This pattern suggests a theme of renal/vascular homeostasis intertwined with metabolic and inflammatory signaling, rather than a single narrow function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000098","count":2},{"id":"GO:0045721","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0042632","count":2},{"id":"GO:0006915","count":2}]},{"hash":"1408946497962866604","title":"Skeletal ossification and mineralization","description":"The cluster is enriched for bone/tooth mineralization processes such as cementum mineralization and endochondral ossification, plus vitamin D response, pointing to roles in skeletal development and mineral homeostasis. Additional terms about proteolysis and matrix remodeling support a bone turnover theme, though some terms (e.g., Purkinje cell differentiation) are broader annotations; overall the skeletal mineralization signal is strongest.","confidence":"Medium","size":19,"edges":101,"triangles":259,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":8},{"id":"GO:0055114","count":8},{"id":"GO:0071529","count":8},{"id":"GO:0006470","count":8},{"id":"GO:0001958","count":8}]},{"hash":"1505052727721230634","title":"Unknown","description":"The top GO terms cover a wide range of unrelated processes (inflammation, metabolism, development, memory, myelination, axon guidance, bone formation, and locomotor rhythms) with no clear shared function, and there are no edges linking proteins in the cluster. This lack of a cohesive theme suggests no specific common function can be inferred.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0090197","count":4},{"id":"GO:0002532","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0006032","count":3},{"id":"GO:0044719","count":2}]},{"hash":"1586789641671357246","title":"Glutamatergic synapse development and signaling","description":"This cluster is driven by terms central to glutamatergic synapses and neural development: ionotropic glutamate receptor signaling, glutamatergic synaptic transmission, cerebellar granule cell differentiation, and pons maturation, with supporting roles for calcium transport and receptor recycling. The inclusion of anterior lateral line development suggests roles in sensory-brain development, making a concise theme of glutamatergic synapse formation and activity in neural and sensory systems.","confidence":"High","size":19,"edges":56,"triangles":85,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":7},{"id":"GO:0045471","count":7},{"id":"GO:0035235","count":6},{"id":"GO:0048899","count":5},{"id":"GO:0035249","count":5}]},{"hash":"1099336224603222957","title":"Ion and Nutrient Transmembrane Transporters","description":"The cluster is strongly enriched for transmembrane transport activities, especially for ions (sodium and potassium), nitrates/nitrite, sugars (galactose), fucose, vitamins, and xenobiotics. This pattern points to a set of transporter proteins that mediate movement of diverse substrates across membranes, rather than enzymes or signaling proteins.","confidence":"High","size":19,"edges":11,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":15},{"id":"GO:0071805","count":15},{"id":"GO:0006855","count":12},{"id":"GO:0042128","count":12},{"id":"GO:0006004","count":12}]},{"hash":"2220898732448521310","title":"Organ Development Regulation","description":"Dominant themes are organ development signals across multiple tissues (exocrine pancreas development, midbrain development, post-embryonic development) with robust regulatory activity (transcription by RNA Pol II, regulation of cell proliferation). The presence of immune-related terms (leukocyte tethering/rolling, regulation of chemokine production) and metabolic responsiveness (cellular response to glucose) likely reflect broader regulatory contexts rather than distinct sub-processes. Overall, the cluster appears to be a module of developmental regulation spanning organs.","confidence":"High","size":19,"edges":21,"triangles":10,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":19},{"id":"GO:0031017","count":19},{"id":"GO:1903238","count":19},{"id":"GO:0051919","count":19},{"id":"GO:0030901","count":19}]},{"hash":"2209812903723492335","title":"Amino acid transport into vacuole (plants)","description":"The top GO terms are dominated by transport of specific amino acids into the vacuole (tyrosine, glutamate, arginine, serine, alanine, proline) and related transmembrane movement, indicating a cluster of vacuolar amino acid transport proteins. Some terms about root cap development and potassium starvation appear but do not outweigh the clear transport theme. ","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090514","count":4},{"id":"GO:0090515","count":4},{"id":"GO:1990818","count":4},{"id":"GO:0015808","count":4},{"id":"GO:0090516","count":4}]},{"hash":"1650999148494396091","title":"Amino acid and polyamine transport","description":"This cluster\u2019s top GO terms are dominated by transmembrane transport of amino acids (L-arginine, L-ornithine), polyamines, ammonium and ions, with related terms for nitric oxide biosynthesis and macrophage activation. The common thread is membrane transport of nitrogenous compounds, suggesting a cohesive transport-focused function across these proteins.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006884","count":3},{"id":"GO:1902269","count":2},{"id":"GO:1902274","count":2},{"id":"GO:0071477","count":2},{"id":"GO:0035826","count":2}]},{"hash":"2270776367270048331","title":"Cell Cycle and RNA Processing","description":"This cluster centers on cell division and mitosis, complemented by RNA processing/export and intracellular trafficking (ER-Golgi transport, intraflagellar transport) as well as protein turnover and post-translational modification regulation, suggesting a module that coordinates cell cycle progression with gene expression and trafficking.","confidence":"Medium","size":18,"edges":132,"triangles":574,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0006406","count":5},{"id":"GO:0006888","count":5},{"id":"GO:0000278","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1593228141172485533","title":"Chromosome maintenance and cell cycle","description":"The top GO terms are dominated by DNA replication, DNA-templated transcription, mitotic cell cycle, and cell division, with CENP-A\u2013containing chromatin assembly and microtubule severing pointing to chromosome maintenance and segregation. A vesicle transport term appears but overall the cluster centers on nuclear processes tied to replication and mitosis. ","confidence":"High","size":18,"edges":151,"triangles":785,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0071276","count":3}]},{"hash":"1504840411159740596","title":"Cardiac hypoxia response and secretory signaling","description":"The cluster centers on hypoxia-related and heart development processes, with accompanying signals for cell proliferation, cytoskeletal remodeling (Rho), secretion (exosomes, ATP export), and general gene-expression control (splicing and translation initiation). This points to a cardiac stress response network involving secretory communication and adaptive gene expression.","confidence":"Medium","size":18,"edges":64,"triangles":117,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0008284","count":3},{"id":"GO:1990182","count":2},{"id":"GO:1904669","count":2}]},{"hash":"1115311795066877563","title":"ER Proteostasis and Ubiquitin Pathways","description":"Top GO terms are dominated by protein modification and turnover: protein sumoylation, deubiquitination, and ubiquitin-dependent protein catabolic processes, plus signals relating to ER-associated degradation and insertion of tail-anchored membrane proteins into the ER. Translation and ribosome maturation terms appear but are secondary. Taken together, these terms point to a cluster centered on proteostasis in the secretory pathway, i.e., how cells modify, fold, and dispose of proteins via the ER and ubiquitin system. Immune signaling term is incidental.","confidence":"Medium","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":13},{"id":"GO:0034126","count":10},{"id":"GO:1904378","count":8},{"id":"GO:0006412","count":8},{"id":"GO:0010216","count":7}]},{"hash":"2030983807290963982","title":"Insect chemosensory signaling and pheromone-driven behavior","description":"This cluster is driven by chemical sensing and behavioral responses to chemical cues in insects. The top GO terms highlight detection and perception of chemical stimuli (carbon dioxide, bitter taste) and responses to chemicals (caffeine, insecticides, L-canavanine), along with pheromone-mediated courtship and general chemosensory behavior, suggesting a cohesive theme of chemosensory signaling shaping insect behavior.","confidence":"High","size":18,"edges":18,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0003031","count":9},{"id":"GO:0031000","count":9},{"id":"GO:0017085","count":9},{"id":"GO:1901354","count":9},{"id":"GO:0050913","count":9}]},{"hash":"1849764289051826877","title":"Glutamatergic synaptic transmission and AMPA receptor regulation","description":"This cluster is dominated by terms tied to excitatory synaptic signaling, especially glutamatergic transmission and AMPA receptor activity/trafficking, including positive/negative regulation of EPSPs and receptor internalization. While there are a few developmental terms (retina, osteoblast, heart), the strongest signals point to neuronal synapse function and receptor regulation as the core theme.","confidence":"High","size":18,"edges":32,"triangles":31,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0002076","count":8},{"id":"GO:0002087","count":8},{"id":"GO:0060041","count":8},{"id":"GO:2000463","count":6},{"id":"GO:0008285","count":6}]},{"hash":"1979597509741558083","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"This cluster shows enrichment in GO terms related to actin-driven processes and cell movement, such as lamellipodium and stress fiber assembly, axon guidance, and chemotaxis, along with endocytic recycling which often depends on the cytoskeleton. While there is a mention of mitotic spindle assembly (microtubule-related), the dominant theme is cytoskeletal remodeling and migration-like processes.","confidence":"Medium","size":18,"edges":9,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0055013","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0032456","count":2},{"id":"GO:0002551","count":2}]},{"hash":"1803129389250102793","title":"Neural development and mechanosensory signaling","description":"The cluster contains GO terms tied to neural differentiation (cerebellar granule cell differentiation, oligodendrocyte differentiation) along with sensory perception terms (pain detection, thermoception) and mechanosensitive/cytoskeletal signaling (actin filament bundle assembly, cellular response to mechanical stimulus, calcium release). This pattern suggests a shared theme around neural development coupled with mechanosensory and calcium signaling pathways, rather than a single, narrow process.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":4},{"id":"GO:0071260","count":4},{"id":"GO:0021707","count":4},{"id":"GO:0051209","count":3},{"id":"GO:1904908","count":3}]},{"hash":"1133191105590434194","title":"Cardiac electrophysiology and potassium transport","description":"The cluster centers on cardiac electrical activity: atrial and AV node action potentials, membrane depolarization/repolarization, heart-rate regulation by conduction, and potassium ion import/export. This pattern strongly suggests proteins involved in cardiac excitability and ion handling, especially potassium dynamics. A single term about mechanosensation is peripheral to the main theme. Overall, the cluster represents cardiac electrophysiology and potassium transport.","confidence":"High","size":18,"edges":70,"triangles":144,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0098914","count":13},{"id":"GO:0050976","count":12},{"id":"GO:0086091","count":11},{"id":"GO:0086002","count":11},{"id":"GO:1990573","count":11}]},{"hash":"2212797377104357645","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":99,"triangles":272,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0010124","count":6},{"id":"GO:0009234","count":5},{"id":"GO:0006635","count":5},{"id":"GO:0042372","count":5}]},{"hash":"743730655382522484","title":"Insect pheromone signaling and caste-related development","description":"Proteins in this cluster are enriched for pheromone response, olfactory perception, social behavior, and caste determination influenced by environmental factors, along with larval cuticle development and pigmentation. The convergence of pheromone sensing, mating behavior, and caste differentiation strongly suggests an insect social-development module governing communication, reproduction, and integumentary maturation.","confidence":"High","size":18,"edges":29,"triangles":11,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0008363","count":2}]},{"hash":"260104371861754731","title":"Neural development with axon/cytoskeleton regulation","description":"Top GO terms indicate brain development and connectivity (corpus callosum development, axonal fasciculation, synapse assembly) alongside cytoskeletal control (actin depolymerization) and protein turnover (ubiquitination). The cluster seems to group proteins involved in neurite outgrowth, axon wiring, and synaptic assembly through cytoskeletal dynamics and related regulation.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030835","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0022038","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1325192425827603309","title":"Embryonic development and organ morphogenesis","description":"These terms converge on developmental biology, spanning body axis specification (left\u2013right patterning, dorsal/ventral axis), tissue morphogenesis (cartilage), organ-specific differentiation (pancreatic cells, placental trophoblast), EMT in heart development, and germline formation. The cluster seems to group proteins involved in diverse developmental stages rather than a single pathway, so a broad label like Embryonic development and organ morphogenesis best captures the shared theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0007311","count":3},{"id":"GO:0045998","count":3}]},{"hash":"1447041553415857163","title":"Translation Initiation and Proteasome Regulation","description":"The cluster includes GO terms for formation of the translation preinitiation complex and regulation of translational initiation, alongside proteasome-mediated ubiquitin-dependent degradation, proteasome assembly, COP9 signalosome assembly, and regulation of deneddynlation. This combination suggests a coordinated module linking protein synthesis with degradation and post-translational modification to control proteostasis and related signaling (e.g., NF-kappaB). ","confidence":"Medium","size":18,"edges":84,"triangles":206,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:1903955","count":3},{"id":"GO:0043161","count":3},{"id":"GO:0000338","count":3},{"id":"GO:0043248","count":3}]},{"hash":"1586573225837687195","title":"Developmental patterning and organogenesis","description":"The top terms cluster around embryonic axis specification (dorsal/ventral polarity), left-right patterning, and germline pole cell formation, along with diverse organogenesis processes (endocrine system, pancreas development, cartilage morphogenesis, trophoblast differentiation, and endocardial EMT). A housekeeping process like mRNA splicing is present but does not obscure the overall developmental theme, suggesting these proteins function broadly in developmental patterning and tissue formation. ","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007311","count":3},{"id":"GO:0045998","count":3},{"id":"GO:0007279","count":3},{"id":"GO:0000398","count":2},{"id":"GO:0060972","count":2}]},{"hash":"2097023260453543719","title":"Neuronal Growth Signaling and Actin Remodeling","description":"The enriched terms center on neuronal development and growth signaling (positive regulation of neuron projection development, cerebellum morphogenesis, EGFR/PDGFR pathways) and cytoskeletal remodeling (actin filament branching). The presence of ER stress\u2013related translation regulation and cytokine production hints at broader cellular states but does not outweigh the core theme of neuron-focused signaling and cytoskeletal dynamics.","confidence":"High","size":18,"edges":136,"triangles":632,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010976","count":17},{"id":"GO:0007173","count":17},{"id":"GO:0021587","count":16},{"id":"GO:0010641","count":16},{"id":"GO:0045737","count":16}]},{"hash":"238949516002207269","title":"Mitochondrial translation and respiratory chain assembly","description":"This cluster centers on mitochondrial function, with GO terms for mitochondrial electron transport and complex II assembly, plus translation and tRNA metabolic processes, including regulation of translational fidelity and protein targeting to membranes such as the ER and mitochondrial membranes. The combination suggests a cohesive role in mitochondrial gene expression and the import/import-driven assembly of respiratory complexes, especially complex II, making this a mitochondria-focused translation/assembly cluster.","confidence":"High","size":18,"edges":41,"triangles":47,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006412","count":2},{"id":"GO:1900832","count":1},{"id":"GO:0006450","count":1}]},{"hash":"937448910556620252","title":"ECM Remodeling in Bone and Kidney with Innate Immunity","description":"The terms point to extracellular matrix organization (collagen fibrils, cross-linking) and bone development, alongside kidney development, while also showing innate immune and chemokine-related activity. This suggests a cluster of ECM remodeling during skeletal and renal development with concurrent immune signaling.","confidence":"Medium","size":18,"edges":72,"triangles":120,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060348","count":15},{"id":"GO:0019800","count":15},{"id":"GO:0051607","count":13},{"id":"GO:0045087","count":13},{"id":"GO:0045842","count":13}]},{"hash":"366761523166104545","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":150,"triangles":770,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0033615","count":2},{"id":"GO:0042823","count":2},{"id":"GO:0008615","count":2},{"id":"GO:0002047","count":2}]},{"hash":"690553772397867970","title":"Spinal Cord Neuron Development and Axon Guidance","description":"The top GO terms are dominantly neural: ventral spinal cord interneuron specification, motor neuron axon guidance, visceral motor neuron differentiation, and spinal cord association neuron differentiation, pointing to spinal cord neuron development and axon pathfinding. A few terms about kidney and heart development exist but do not outweigh the neural differentiation signal. Confidence: Medium.","confidence":"","size":18,"edges":89,"triangles":234,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021521","count":14},{"id":"GO:0008045","count":13},{"id":"GO:0035849","count":12},{"id":"GO:0021524","count":12},{"id":"GO:0021527","count":12}]},{"hash":"371114297914639943","title":"Embryonic development and tissue morphogenesis","description":"The cluster is dominated by embryonic development and tissue morphogenesis terms across various lineages (left-right patterning, cartilage and skeletal muscle morphogenesis, placental and pancreatic cell differentiation, EMT in endocardial cushion formation, and blastocyst formation). This suggests the proteins work together in developmental differentiation and organogenesis rather than a single pathway.","confidence":"High","size":18,"edges":145,"triangles":697,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":6},{"id":"GO:0003323","count":6},{"id":"GO:0060536","count":6},{"id":"GO:0060707","count":6},{"id":"GO:0003198","count":6}]},{"hash":"444192921127130706","title":"Flavonoid Biosynthesis and Phenylpropanoid Metabolism","description":"This cluster is dominated by GO terms for flavonoid biosynthesis (anthocyanin, kaempferol, quercetin, cyanidin glucosides) and related phenylpropanoid pathways like lignin metabolism and flavonoid glucuronidation, indicating proteins involved in plant secondary metabolite production and detoxification. ","confidence":"High","size":18,"edges":55,"triangles":130,"max_degree":9,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":10},{"id":"GO:0033330","count":10},{"id":"GO:0009808","count":10},{"id":"GO:0052697","count":10},{"id":"GO:0016999","count":10}]},{"hash":"350444330291594625","title":"Ubiquitin-Dependent Regulation in Immunity and Cell Cycle","description":"The cluster centers on ubiquitin-dependent proteolysis and ubiquitination (including protein polyubiquitination), with supporting signals in B cell receptor signaling, regulation of circadian rhythm, and control of G1/S transcription and CDK activity. While there are some development- and neuron-related terms, the dominant theme is ubiquitin-mediated regulation influencing immune signaling and cell-cycle processes.","confidence":"High","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0050853","count":4},{"id":"GO:0042752","count":3},{"id":"GO:0000083","count":3},{"id":"GO:0045737","count":3}]},{"hash":"2042459091340813943","title":"Muscle differentiation and growth signaling","description":"The terms cluster around muscle development and energetic signaling: myoblast differentiation, IGF receptor signaling, PI3K/AKT pathway, and glycolytic regulation, along with STAT activation. These collectively point to muscle development and its metabolic support, even though a few terms may reflect broader developmental roles. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035630","count":1},{"id":"GO:0050995","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0043491","count":1},{"id":"GO:0042523","count":1}]},{"hash":"1517341365166137899","title":"Unknown","description":"The top terms cover sensory perception (pheromone detection, smell), lipid-related processes (palmitoylation, fatty acid import), immune and epithelial functions (LPS response, GI epithelium maintenance), and neural processing (prepulse inhibition) with no single unifying function, so there isn\u2019t a clear cohesive theme for the cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0018230","count":3},{"id":"GO:0042144","count":3},{"id":"GO:0048733","count":3},{"id":"GO:0032868","count":1}]},{"hash":"2064371969131710567","title":"Unknown","description":"The top GO terms are highly diverse, spanning kidney development, ear tethering, endothelial activation/differentiation, GI epithelium maintenance, BMP signaling regulation, and even a plant-like metabolic process, with no clear single function tying them together. Because of this fragmentation, a cohesive label cannot be confidently assigned to this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001657","count":2},{"id":"GO:0035889","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0042118","count":2},{"id":"GO:0008344","count":2}]},{"hash":"815532724917893352","title":"Innate Immunity and Angiogenesis Development Signaling","description":"This cluster is enriched for innate immune terms (innate immune response and chemokine production) and angiogenesis, with additional signals related to ERK cascade activation and adenosine receptor pathways, plus several development-associated terms (kidney, nervous system, salivary gland development, and myoblast differentiation). The co-occurrence points to a cohesive module linking immune signaling and vascular/tissue development processes, possibly reflecting inflammatory remodeling and organogenesis programs.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0090197","count":6},{"id":"GO:0001525","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0060168","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1077211411986924011","title":"Symbiont-induced immune suppression and ubiquitination","description":"The top GO terms cluster around host-immune interactions with symbionts: suppression of adaptive immunity, antigen processing/presentation via MHC class II, and regulation of tolerance, alongside ubiquitin-related protein modification. This points to a shared function in how symbionts modulate host immunity, potentially via ubiquitin pathways. Some other terms (magnesium homeostasis, cutin/suberin biosynthesis) are less aligned and may reflect incidental associations, but the immune-related terms provide the strongest cohesive signal.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010961","count":2},{"id":"GO:0010143","count":2},{"id":"GO:0000209","count":2},{"id":"GO:1900490","count":2},{"id":"GO:0045347","count":2}]},{"hash":"1990451294846152428","title":"Organ Development and Growth Regulation","description":"The cluster\u2019s top GO terms cluster around organogenesis and growth control, including kidney and lung development, male gonad development, and regulation of BMP signaling and cell growth. While there are some peripheral terms related to coagulation and immune activation, the dominant theme is developmental regulation of organ formation and growth, so this label is representative. ","confidence":"Medium","size":18,"edges":26,"triangles":11,"max_degree":11,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0001558","count":6},{"id":"GO:0010751","count":6},{"id":"GO:0030514","count":6},{"id":"GO:0008584","count":6},{"id":"GO:0010763","count":5}]},{"hash":"1242475556091684786","title":"Innate immune defense and pheromone sensing","description":"This cluster is driven by immune-related GO terms such as antibacterial humoral response, defense against Gram-positive bacteria, and antigen processing/presentation, indicating a core innate immune theme. The pheromone detection term adds a sensory aspect, while a few other terms (larval cuticle development, ERK signaling) may reflect broader developmental or signaling connections or annotation noise. Overall, the strongest cohesive signal is innate immune defense, with secondary cues to sensory signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0019731","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0032504","count":1},{"id":"GO:0008363","count":1}]},{"hash":"757305362490066530","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0051084","count":1},{"id":"GO:0032543","count":1},{"id":"GO:0045041","count":1},{"id":"GO:0022417","count":1}]},{"hash":"1534948943875071201","title":"Developmental Patterning and Morphogenesis","description":"Top GO terms indicate embryonic development, tissue morphogenesis, and patterning across multiple lineages (left/right patterning; mesoderm and cartilage morphogenesis; hair follicle morphogenesis; roof of mouth development; EMT in endocardial cushion formation; endocrine system development). The shared theme across these diverse terms is developmental patterning and organ morphogenesis rather than a single tissue-specific function, justifying a label around general developmental morphogenesis. Confidence: High","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0010957","count":3},{"id":"GO:0007498","count":3}]},{"hash":"1948533372758201423","title":"Peptidoglycan recognition and Gram-positive defense","description":"This cluster is dominated by terms tied to peptidoglycan recognition protein (PGRP) signaling, detection of bacteria, and innate immune defense against Gram-positive bacteria, plus peptidoglycan turnover. The combination suggests a cohesive module centered on sensing peptidoglycan and triggering innate responses to Gram-positive pathogens, consistent with PGRP-mediated signaling pathways.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":4},{"id":"GO:0042787","count":3},{"id":"GO:0009253","count":3},{"id":"GO:0061057","count":3},{"id":"GO:0061060","count":3}]},{"hash":"1199923315744379681","title":"Diverse Biosynthetic Pathways","description":"The top GO terms point to biosynthesis across a range of metabolites (androgen and testosterone biosynthesis, sphingolipid biosynthesis, tropane alkaloid and phylloquinone processes, poly-hydroxybutyrate biosynthesis), suggesting a common theme of metabolic production across different systems. Some terms like lung development or antibiotic response are broader annotations and may reflect peripheral connections or annotation noise, but the core signal is diverse biosynthetic activity.","confidence":"Medium","size":18,"edges":136,"triangles":680,"max_degree":16,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":17},{"id":"GO:0006666","count":17},{"id":"GO:0042619","count":17},{"id":"GO:0042376","count":17},{"id":"GO:0009710","count":17}]},{"hash":"2057063593041229201","title":"Developmental Transcription Regulation","description":"This cluster is enriched for both positive and negative regulation of transcription by RNA polymerase II and for several developmental processes (exocrine pancreas development, midbrain development, post-embryonic development), suggesting a cohesive role in controlling gene expression during development. Some terms related to immune signaling and metabolism (leukocyte tethering/rolling, fibrinolysis, glucose response) may reflect broader regulatory roles or annotation overlap.","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0045944","count":6},{"id":"GO:0031017","count":6},{"id":"GO:1903238","count":6},{"id":"GO:0051919","count":6}]},{"hash":"973790779807652187","title":"Bacterial LPS and capsule biosynthesis","description":"The cluster\u2019s top GO terms strongly point to biosynthesis of bacterial surface polysaccharides: lipopolysaccharide (LPS) and O antigen, colanic acid, and sugar precursors such as dTDP-rhamnose and ADP-L-glycero-beta-D-manno-heptose. This suggests a cohesive function in assembling components of the cell envelope (capsule/LPS) rather than unrelated pathways; a few outlier terms (anthocyanin/sporopollenin biosynthesis) are likely incidental noise. ","confidence":"High","size":18,"edges":122,"triangles":492,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":15},{"id":"GO:0009243","count":15},{"id":"GO:0009103","count":15},{"id":"GO:0097171","count":15},{"id":"GO:0009242","count":15}]},{"hash":"1590063711448821480","title":"Insect metamorphosis and development","description":"Top terms indicate metamorphosis, multicellular organism development, and insect-specific dorsal appendage formation, with a nod to neuropeptide signaling that could reflect neural/hormonal regulation of development. The sparse edges suggest a broad, theme-oriented grouping rather than a tightly connected module, but the clear insect-developmental signals support this label.","confidence":"Medium","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":1},{"id":"GO:0046843","count":1},{"id":"GO:0007275","count":1},{"id":"GO:0007552","count":1},{"id":"GO:0034605","count":1}]},{"hash":"1812876615091974987","title":"Olfactory signaling and social behavior","description":"This cluster is dominated by GO terms related to pheromone response, smell perception, and social behavior, pointing to a core role in olfactory signaling and social cue processing. The lipid transport/metabolism terms appear as secondary associations (e.g., cholesterol transport, HDL remodeling, lipid digestion) that may reflect linked metabolic contexts or pleiotropy, but the olfactory/social theme is most representative of the cluster.","confidence":"Medium","size":18,"edges":12,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":4},{"id":"GO:0007608","count":4},{"id":"GO:0006810","count":4},{"id":"GO:0035176","count":4},{"id":"GO:0090197","count":3}]},{"hash":"107205746342232096","title":"Transmembrane Nutrient and Ion Transporters","description":"The top GO terms show multiple transmembrane transport activities for nutrients and ions (nitrate, potassium, glucose, xylose, sodium-dependent organic cations, selenite) and related cellular responses to osmotic stress and glucose starvation. This pattern points to a cohesive theme of membrane transporter function and nutrient/ion homeostasis, with a few non-specific terms likely representing incidental associations. ","confidence":"High","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":2},{"id":"GO:0060731","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0006970","count":2},{"id":"GO:0097080","count":2}]},{"hash":"2141661267561881208","title":"Ethylene-driven fruit ripening and cell-wall remodeling","description":"This cluster features GO terms for ethylene biosynthesis and fruit ripening, alongside cell-wall\u2013related processes (collagen fibril organization and proline hydroxylation in hydroxyproline-rich proteins) and ROS-associated PCD, plus secondary metabolism (proanthocyanidin biosynthesis). These collectively point to plant ripening, cell-wall modification, and redox signaling as the shared theme.","confidence":"Medium","size":18,"edges":20,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032364","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0032504","count":4},{"id":"GO:0030199","count":4},{"id":"GO:1901874","count":4}]},{"hash":"989105762212532216","title":"Neural development and neuroinflammation","description":"This cluster\u2019s top GO terms emphasize neural development features (myelination, corpus callosum development, regulation of postsynaptic potentials, tyrosine kinase signaling in cell-surface receptors) alongside immune-related processes (innate immune response, inflammatory response, chemokine production). This points to proteins involved in brain development that also participate in immune signaling within the CNS, with some developmental terms (kidney development) acting as outliers. Overall, the label captures the central theme of neural development coupled with inflammatory signaling.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097151","count":3},{"id":"GO:0090394","count":3},{"id":"GO:0090197","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0007169","count":3}]},{"hash":"879904483501514740","title":"Embryogenesis and Reproductive Processes","description":"This cluster centers on developmental and reproductive functions: maternal specification of body axes, embryonic morphogenesis, and mechanisms preventing polyspermy and regulating fertilization, plus related developmental remodeling processes like molting and cuticle formation. While a few terms (e.g., platelet aggregation) are less directly connected, the dominant signal is embryonic development and reproductive regulation.","confidence":"Medium","size":18,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0070527","count":3},{"id":"GO:0018996","count":2},{"id":"GO:0007313","count":2}]},{"hash":"265373411200754006","title":"Heart and skeletal muscle development","description":"The top GO terms cluster around developmental processes for cardiac and skeletal muscle lineages (heart development; muscle cell fate specification; satellite cell activation for muscle regeneration). Retina layer formation appears as a minor signal, and a few terms relate to general transport or regulation, which may be peripheral to the main theme. Overall, the cluster seems focused on differentiation/development of mesoderm-derived tissues, especially heart and muscle, with some incidental eye development signals.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0033234","count":1},{"id":"GO:0019749","count":1},{"id":"GO:0010842","count":1},{"id":"GO:1905205","count":1}]},{"hash":"232531632277679734","title":"Insect chemosensory perception and behavior","description":"The top GO terms cluster around chemosensory perception (bitter taste, odor/pheromone detection, CO2 sensing) and behavior driven by chemical cues (response to caffeine, insecticide, canavanine, pheromone-related courtship), plus related sensory navigation like negative phototaxis. This pattern points to a module of insect chemosensation and stimulus-driven behavior rather than a generalized metabolic function.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0050913","count":8},{"id":"GO:0003031","count":7},{"id":"GO:0031000","count":7},{"id":"GO:0017085","count":7},{"id":"GO:1901354","count":7}]},{"hash":"1339389972132203962","title":"Immune modulation and inflammatory signaling","description":"Most terms are immune-related (negative regulation of mast cell activation, positive regulation of type I and III hypersensitivity, natural killer cell activation, interleukin-1\u2013mediated signaling, and STAT phosphorylation), pointing to a theme of immune activation/modulation and inflammatory signaling. A couple of development-related terms (glomerulus morphogenesis, trigeminal nerve development) may reflect broader regulatory roles or annotation breadth, but the dominant signal is immune signaling. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033004","count":4},{"id":"GO:0072102","count":4},{"id":"GO:0001812","count":4},{"id":"GO:2000661","count":4},{"id":"GO:0021740","count":4}]},{"hash":"1097503486473266536","title":"GPCR Signaling and Physiological Regulation","description":"The top GO terms cluster around G protein-coupled receptor signaling, especially adenylate cyclase-activating and adrenergic pathways, with related physiological processes like blood pressure regulation, circadian rhythm, and ERK signaling. Immune-related terms (eosinophil chemotaxis, IgA isotype switching) also align with GPCR-linked regulatory roles. A single outlier term (electron transport chain) is likely not defining the core function, suggesting the cluster centers on GPCR-driven signaling and broad physiological regulation.","confidence":"Medium","size":18,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0001698","count":17},{"id":"GO:0072224","count":17}]},{"hash":"947506964129594293","title":"mRNA Splicing and Stability Regulation","description":"This cluster is dominated by GO terms for mRNA processing: splicing via the spliceosome, regulation of alternative splicing, and mRNA stabilization/stability, plus a note on small-subunit processome assembly. The presence of translation-related terms (eukaryotic translation initiation factor 4F complex assembly) suggests a broader link between RNA processing and translation initiation, indicating proteins involved in RNA maturation and its coordination with protein synthesis.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":10},{"id":"GO:0045292","count":10},{"id":"GO:0048255","count":9},{"id":"GO:0034462","count":9},{"id":"GO:1901407","count":9}]},{"hash":"217879479045320519","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":3},{"id":"GO:0006407","count":2},{"id":"GO:0090394","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0000462","count":2}]},{"hash":"154741918794982654","title":"Innate immune response and chemotaxis","description":"This cluster centers on innate immunity and directed cell movement, with strong signals for innate immune response and chemotaxis, and supportive links to microtubule-level transport and cell cycle roles that facilitate immune cell migration and function. While transcription and development terms appear, the dominant theme is immune signaling coupled to movement.","confidence":"Medium","size":17,"edges":28,"triangles":15,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035372","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0045087","count":10},{"id":"GO:0007275","count":10},{"id":"GO:0006351","count":8}]},{"hash":"536041742710221475","title":"Spliceosome-driven mRNA splicing and processing","description":"The cluster is dominated by GO terms centered on spliceosome-mediated mRNA splicing and its regulation, including alternative splicing, as well as mRNA stabilization and small-subunit processome assembly. This indicates a cohesive theme around post-transcriptional RNA processing and gene expression regulation at the RNA level, with some entries touching on ncRNA-mediated silencing. ","confidence":"High","size":17,"edges":108,"triangles":378,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":4},{"id":"GO:0000381","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0035278","count":4},{"id":"GO:0031047","count":4}]},{"hash":"459100870127113303","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000462","count":14},{"id":"GO:0042273","count":14},{"id":"GO:1902626","count":14},{"id":"GO:0031124","count":13},{"id":"GO:0016973","count":13}]},{"hash":"2084873097936768790","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":72,"triangles":142,"max_degree":15,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0007275","count":8},{"id":"GO:0000462","count":7},{"id":"GO:0000466","count":7},{"id":"GO:0000398","count":7}]},{"hash":"1298016441862081416","title":"RNA Processing and Mitotic Control","description":"This cluster's GO terms cluster around RNA metabolism (mRNA transport/export, NMD, translational regulation) and mitotic cell-cycle control (mitotic cell cycle, APC/C-dependent degradation, K11-linked ubiquitination), suggesting a functional module where RNA processing is coordinated with cell division.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0051028","count":3},{"id":"GO:0051754","count":3},{"id":"GO:0000184","count":2},{"id":"GO:0098789","count":2},{"id":"GO:0006446","count":2}]},{"hash":"1050557341720211368","title":"Protein folding and membrane-targeting quality control","description":"The strongest signals are chaperone-assisted folding, ER-associated degradation, heat-stress regulation, and protein targeting to membranes and mitochondria, indicating a proteostasis/quality-control cluster centered on protein folding and membrane localization. A few unrelated terms (DNA replication, mesoderm formation) are present but less indicative.","confidence":"Medium","size":17,"edges":118,"triangles":509,"max_degree":15,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031204","count":15},{"id":"GO:0090084","count":15},{"id":"GO:0070389","count":15},{"id":"GO:1900035","count":15},{"id":"GO:0030433","count":15}]},{"hash":"2050942897550633812","title":"Cilium/Flagellum assembly and dynein arm function","description":"Strongly points to cilium/flagellum biogenesis and motility, including inner dynein arm assembly, cilium assembly, and protein localization to the cilium, plus spermatid development (sperm flagellum). Kidney-related and other terms likely reflect broader tissue contexts, but the core theme is ciliary structure and motion.","confidence":"High","size":17,"edges":108,"triangles":433,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0007286","count":2},{"id":"GO:0036159","count":2},{"id":"GO:2000574","count":2},{"id":"GO:0097205","count":1},{"id":"GO:0060271","count":1}]},{"hash":"1607574160502907647","title":"Purine Nucleoside Salvage and Methionine Recycling","description":"Top GO terms indicate salvage and catabolic processing of purines and nucleosides (purine nucleoside salvage, purine ribonucleoside salvage, inosine/uridine catabolism, purine interconversion). The methionine salvage terms (from SAM and methylthioadenosine) link these processes to methionine recycling, suggesting involvement in the MTA cycle. Overall, the cluster likely comprises proteins dedicated to salvage of purine nucleosides and related metabolites.","confidence":"High","size":17,"edges":20,"triangles":6,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019284","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0006161","count":1},{"id":"GO:0019686","count":1},{"id":"GO:0006218","count":1}]},{"hash":"894578450440238818","title":"Kynurenine/Tryptophan Catabolism and Amino Acid Metabolism","description":"This cluster is dominated by GO terms related to amino acid catabolism, especially tryptophan/kynurenine metabolism (kynurenine and kynurenic acid biosynthesis) and alanine catabolism, along with several related biosynthetic processes (biotin, protoporphyrinogen IX). The Notch signaling term appears less central, possibly as a secondary function or annotation noise. Overall, the shared theme is amino acid catabolism with kynurenine pathway involvement, justifying the label.","confidence":"Medium","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0097053","count":9},{"id":"GO:0042853","count":9},{"id":"GO:0007219","count":9},{"id":"GO:0009102","count":9},{"id":"GO:0019878","count":9}]},{"hash":"83563028051982597","title":"Transcription-Associated DNA Repair","description":"These terms cluster around transcription (RNA polymerase II and I activity, elongation, termination) and both transcription-coupled and general nucleotide-excision repair, with additional hints of RNA processing/export and stress responses. This points to proteins that coordinate transcription with DNA repair and RNA processing rather than a single isolated function.","confidence":"High","size":17,"edges":27,"triangles":13,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0006362","count":2},{"id":"GO:0006363","count":2},{"id":"GO:0006283","count":2},{"id":"GO:0009636","count":2}]},{"hash":"1108252017859500564","title":"Ubiquitin-Dependent Proteolysis and RNA Processing","description":"This cluster is enriched for ubiquitin-mediated protein catabolic processes and RNA metabolism activities (spliceosome-mediated mRNA splicing, ribosomal subunit export from the nucleus, and regulation of ubiquitination). These point to a module centered on protein turnover and RNA processing, with additional, broader terms like circadian rhythm and development likely reflecting multifunctional proteins in the set.","confidence":"Medium","size":17,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0000398","count":2},{"id":"GO:1902188","count":2},{"id":"GO:0070914","count":2},{"id":"GO:0000055","count":2}]},{"hash":"1605406608398641801","title":"Cardiac and skeletal muscle contraction regulation","description":"The top GO terms cluster around muscle contraction and its regulation across cardiac and skeletal tissues, including ventricular morphogenesis, regulation of both striated and smooth muscle contraction, slow-twitch fiber contraction, muscle filament sliding, and ATP-dependent activity. This indicates proteins in this cluster are primarily involved in contractile machinery and its control in muscle types.","confidence":"High","size":17,"edges":35,"triangles":19,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0055010","count":5},{"id":"GO:0006942","count":5},{"id":"GO:0006940","count":5},{"id":"GO:0031444","count":5},{"id":"GO:0032972","count":5}]},{"hash":"477443027743838562","title":"Unknown","description":"The GO terms are spread across metabolism (coenzyme A biosynthesis), epigenetic modification (methylation), signal regulation (dephosphorylation; TGF-beta signaling), development and hematopoiesis (hemopoiesis; pro-B cell differentiation; kidney development), stress response, and localization. There is no single cohesive biological function linking the set, so a specific label cannot be assigned. ","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015937","count":2},{"id":"GO:0016311","count":2},{"id":"GO:0032259","count":2},{"id":"GO:0030097","count":2},{"id":"GO:0009636","count":2}]},{"hash":"821063703048427295","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":43,"triangles":46,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0007584","count":6},{"id":"GO:0006189","count":5},{"id":"GO:0006531","count":4},{"id":"GO:0042594","count":4}]},{"hash":"917310433259547702","title":"Central Carbon Metabolism","description":"The cluster\u2019s GO terms are dominated by glycolysis, TCA cycle, and related carbon shuttles (glycolytic process, TCA cycle, glyoxylate cycle, oxaloacetate and malate metabolism), with supporting nutrient signaling (response to nutrient, response to glucose, cAMP). This points to a cohesive group of proteins centered on energy production from carbohydrates and central carbon flux, with ancillary regulatory responses.","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":10},{"id":"GO:0055114","count":8},{"id":"GO:0006096","count":8},{"id":"GO:0007584","count":6},{"id":"GO:0051591","count":5}]},{"hash":"108579280903811865","title":"Ionotropic Glutamate Receptor Signaling","description":"The dominating GO terms point to glutamatergic synaptic function, including ionotropic glutamate receptor signaling, synaptic transmission, and excitatory postsynaptic potentials, with accompanying calcium ion transport. While developmental terms like pons maturation and anterior lateral line development appear, the core theme is glutamatergic neurotransmission at synapses. ","confidence":"High","size":17,"edges":13,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":7},{"id":"GO:0045471","count":7},{"id":"GO:0060079","count":7},{"id":"GO:0048899","count":6},{"id":"GO:0035249","count":6}]},{"hash":"575062134488343091","title":"Unknown","description":"The cluster's top GO terms span several unrelated biological areas (phototropism, immune regulation, kidney morphogenesis, neural activity) and include ubiquitination processes, with no clear shared function. Therefore I cannot assign a coherent, specific label.","confidence":"","size":17,"edges":31,"triangles":14,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":5},{"id":"GO:0009638","count":4},{"id":"GO:0048294","count":4},{"id":"GO:0043380","count":4},{"id":"GO:0045497","count":4}]},{"hash":"629189270517211707","title":"Ubiquitin-Proteasome System in Inflammation","description":"This cluster centers on proteolysis and protein turnover via the ubiquitin-proteasome system (protein deubiquitination, proteasome core assembly, ubiquitin-independent proteolysis) and inflammatory signaling (non-canonical NF-kappaB, TNF-mediated, Fc-epsilon receptor pathways, and inflammatory response regulation). The combination suggests a cohesive theme where regulated proteolysis interfaces with inflammation and immune signaling, with some stress-response hints (e.g., salt stress). Overall, a label focusing on ubiquitin-proteasome\u2013driven proteolysis and inflammatory signaling is appropriate.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":17},{"id":"GO:0002862","count":17},{"id":"GO:0080129","count":17},{"id":"GO:0010499","count":17},{"id":"GO:0038061","count":17}]},{"hash":"1651135106492650726","title":"Actin Cytoskeleton Remodeling and GTPase/Rac Signaling","description":"The cluster is enriched for terms linking actin cytoskeleton organization, stress fiber regulation, and GTPase activity/Rac signaling, plus growth factor receptor pathways (GH and IGF). This points to a coordinated module of cytoskeletal dynamics governed by small GTPases and modulated by growth factor signals, with a hint of developmental morphogenesis. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0008272","count":3},{"id":"GO:0007480","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0051497","count":2}]},{"hash":"329150466678692296","title":"Glutamatergic synapse function","description":"The top GO terms are dominated by neuronal synapse and glutamatergic signaling: positive regulation of excitatory postsynaptic potentials, glutamate secretion, chemical synaptic transmission, and retrograde nitric oxide signaling, along with receptor clustering and actin cytoskeleton organization that support synaptic structure. Some terms (microvillus assembly, bile acid secretion, endothelial barrier establishment) are less directly related to neurons and may reflect broader or incidental annotations, but the strongest signal centers on excitatory synapse activity and organization.","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:2000463","count":17},{"id":"GO:0014047","count":17},{"id":"GO:0030033","count":17},{"id":"GO:0090179","count":17},{"id":"GO:0030036","count":17}]},{"hash":"622551674265749550","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0035753","count":2},{"id":"GO:1900264","count":2},{"id":"GO:0007064","count":2}]},{"hash":"148452109632266297","title":"Immune development and signaling","description":"The cluster is dominated by GO terms pointing to immune system processes: innate immune response, thymus development, and regulation of NFAT signaling, along with PI3K/AKT pathway modulation relevant to immune cell activation. This combination suggests proteins involved in immune development and signaling, with transcriptional regulation as a supporting theme. Some terms (transcription, cell cycle, stress responses) are broader, but the core pattern centers on immunity and immune cell signaling.","confidence":"High","size":17,"edges":53,"triangles":63,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008542","count":16},{"id":"GO:0045087","count":16},{"id":"GO:0051897","count":16},{"id":"GO:0006351","count":16},{"id":"GO:0051534","count":16}]},{"hash":"1206886903489435988","title":"RNA processing and translation initiation","description":"This cluster seems to group proteins involved in RNA maturation and the initiation of protein synthesis: terms for mRNA stabilization, spliceosome-regulated splicing, small-subunit processome assembly, and mRNA polyadenylation regulation point to RNA processing, while eIF4F complex assembly and IRES-dependent translation initiation (including viral termination-reinitiation) indicate involvement in translation initiation. The common theme is RNA processing followed by translation initiation rather than other cellular processes.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048255","count":1},{"id":"GO:0034462","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0000381","count":1},{"id":"GO:1900363","count":1}]},{"hash":"1611591229224096431","title":"Antennal and eye development with chromatin regulation","description":"The terms cluster around antennal and photoreceptor/eye development, plus regulation of transcription and chromatin state (heterochromatin formation, dosage compensation). Cytoskeletal processes (actin movement, microtubule minus-end localization) also appear, suggesting coordinated developmental gene regulation and chromatin remodeling in sensory organ formation. This makes the label a concise reflection of the dominant themes.","confidence":"Medium","size":17,"edges":9,"triangles":1,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":5},{"id":"GO:0006351","count":4},{"id":"GO:0007469","count":4},{"id":"GO:0045316","count":4},{"id":"GO:0009047","count":3}]},{"hash":"1780711370216310832","title":"Neural signaling, cilium dynamics, and mitophagy","description":"The cluster prominently features neuronal communication terms (neuron-neuron synaptic transmission; learning; fear response) alongside mitochondrial regulation (calcium import into the mitochondrion; regulation of autophagy of mitochondrion; ROS metabolism) and cilium-related regulation (regulation of cilium assembly). This suggests a cohesive theme centered on neural signaling with mitochondrial quality control and ciliary dynamics, with some broader ion transport signals supporting cellular excitability.","confidence":"Medium","size":17,"edges":102,"triangles":316,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:1902017","count":6},{"id":"GO:0030855","count":6},{"id":"GO:0006820","count":6},{"id":"GO:0036444","count":6},{"id":"GO:0007270","count":6}]},{"hash":"1152294865459182971","title":"Unknown","description":"Top terms span metabolism, development, neural regulation, immunity, and extracellular matrix processes with no single cohesive theme; therefore a specific, unified label cannot be assigned.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006006","count":3},{"id":"GO:0033499","count":3},{"id":"GO:0001890","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0048692","count":2}]},{"hash":"565868750402388849","title":"Developmental and Immune Signaling","description":"The terms cluster around developmental processes (angiogenesis, organ induction, lymphoid differentiation) and immune function (complement activation), with supporting roles in transcription and signaling; this suggests proteins involved in development and immune signaling rather than a single pathway.","confidence":"Medium","size":17,"edges":17,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0006958","count":3},{"id":"GO:0014068","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0060168","count":2}]},{"hash":"1384701268032798344","title":"Cardiovascular and neural development","description":"The GO terms center on morphogenesis of heart structures (outflow tract) and vasculature branching, plus Schwann cell development, indicating a developmental program spanning cardiovascular and peripheral nervous system lineages. Supporting terms (EMT regulation, endopeptidase regulation, ion transport) are ancillary and do not redefine the core theme. ","confidence":"Medium","size":17,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0010719","count":2},{"id":"GO:0003151","count":2}]},{"hash":"2249877770452379647","title":"Mitochondrial Energy Metabolism and Calcium Homeostasis","description":"Based on the GO terms, the cluster is enriched for mitochondrial electron transport (NADH to ubiquinone), adenosine metabolism, and intracellular calcium ion homeostasis. These collectively point to mitochondrial energy production and calcium regulation as a core theme. Other terms like testosterone response, epoxygenase P450 pathway, and zinc transport are less central and may reflect secondary or pleiotropic roles. Overall, the main cohesive signal appears to be mitochondria-centered metabolism and ion balance.","confidence":"Medium","size":17,"edges":95,"triangles":234,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006120","count":2},{"id":"GO:0033574","count":1},{"id":"GO:0016311","count":1},{"id":"GO:0046085","count":1},{"id":"GO:0006874","count":1}]},{"hash":"1435608422197420777","title":"Cardiac Ion Homeostasis and Membrane Potential Regulation","description":"This cluster's GO terms center on maintaining ion gradients and calcium signaling that regulate heart muscle function\u2014transmembrane transport, calcium, sodium and potassium homeostasis, and membrane repolarization\u2014indicating proteins involved in cardiac ion handling and membrane potential maintenance, with a minor link to heart morphogenesis through cell adhesion.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090662","count":1},{"id":"GO:0006874","count":1},{"id":"GO:1903278","count":1},{"id":"GO:0030007","count":1},{"id":"GO:0010882","count":1}]},{"hash":"1929062239901970205","title":"Tissue Morphogenesis & ECM Signaling","description":"The GO terms point to developmental tissue formation across multiple organs (glomerular basement membrane, cartilage, skin, eye, oviduct, aorta) and to extracellular matrix\u2013related signaling (collagen-activated receptor pathways) plus cell adhesion. This suggests a cohesive theme of morphogenesis guided by ECM interactions and adhesion dynamics during organ formation. Confidence in this label is high due to the clear cross-tissue morphogenesis and ECM signaling signals.","confidence":"High","size":17,"edges":12,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032836","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0035848","count":2},{"id":"GO:1903225","count":2}]},{"hash":"928693941922531713","title":"Body morphogenesis and cuticle/ECM formation","description":"The top GO terms cluster around body morphogenesis, chitin-based cuticle development, and collagen fibril organization, with supporting roles from prolyl hydroxylation and ectodermal/fetal-like developmental processes. This pattern points to proteins involved in developmental shape formation and extracellular matrix or cuticle assembly, likely in an invertebrate context. Confidence is Medium.","confidence":"","size":17,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0032364","count":1},{"id":"GO:0055114","count":1}]},{"hash":"1173177173543084731","title":"Calcium-regulated reproductive and vascular signaling","description":"The top terms cluster around regulatory processes in calcium signaling and cellular growth, with specific emphasis on reproduction (acrosome reaction, male germ cell proliferation), vascular biology (endothelial cell proliferation), calcium handling (store-operated calcium entry, calcium import), and related regulatory control (serine-type endopeptidase activity, antibacterial peptide production). This suggests a general theme of calcium-linked regulatory signaling across reproductive and vascular contexts.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:2001256","count":1},{"id":"GO:0060046","count":1},{"id":"GO:0002176","count":1},{"id":"GO:0001937","count":1}]},{"hash":"356581930702483097","title":"Negative Regulation of Signaling and Membrane Trafficking","description":"The GO terms point to several instances of negative regulation across signaling pathways (e.g., Ras, activin receptor signaling, SMAD-related processes) together with processes linked to cytoskeletal remodeling and vesicle trafficking (lamellipodium assembly, synaptic vesicle priming, acrosome reaction, neutrophil degranulation). This suggests a coherent theme of proteins that inhibit signaling and regulate membrane/cytoskeletal dynamics, justifying a label that captures both aspects.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043314","count":2},{"id":"GO:0030579","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0016082","count":2}]},{"hash":"1072047095761338660","title":"Chitinase-mediated inflammation and chemokine production","description":"Based on the top GO terms, the cluster centers on immune/inflammatory functions, especially inflammatory mediator production and chemokine production. The presence of chitin catabolic process hints at chitinase activity that can participate in defense against chitin-containing pathogens and modulate inflammation, while the carbohydrate metabolic process may reflect metabolic shifts during immune responses. Altogether, the terms cohere around chitinase-associated inflammatory signaling.","confidence":"Medium","size":17,"edges":57,"triangles":120,"max_degree":12,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002532","count":16},{"id":"GO:0005975","count":16},{"id":"GO:0090197","count":16},{"id":"GO:0006032","count":16}]},{"hash":"703347817880212167","title":"Embryonic morphogenesis and organ development","description":"Because the top GO terms repeatedly specify embryonic morphogenesis across multiple organ systems (cranial skeleton, limbs, skeletal system, forebrain/spinal cord, kidney ureteric bud, hypophysis, gonads), the cluster represents embryonic development and organogenesis.","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":13},{"id":"GO:0048701","count":13},{"id":"GO:0021527","count":12},{"id":"GO:0035115","count":12},{"id":"GO:0090190","count":12}]},{"hash":"1051728091367384732","title":"Organelle Protein Import and Respiratory Chain","description":"The top GO terms point to organelle-targeting processes (protein import into chloroplast stroma and mitochondrial matrix) and assembly/insertion into the mitochondrial inner membrane, coupled with mitochondrial electron transport and proton translocation. This pattern suggests a cluster of proteins involved in delivering/importing proteins to organelles and building the components of the respiratory chain. The metabolic term \u201cresponse to food\u201d is secondary noise but does not override the primary theme of organelle protein import and respiration.","confidence":"Medium","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0045037","count":6},{"id":"GO:0032094","count":6},{"id":"GO:0045039","count":6},{"id":"GO:0000002","count":6},{"id":"GO:0030150","count":6}]},{"hash":"537761663157654607","title":"Embryogenesis and organ morphogenesis","description":"This cluster's GO terms cluster around developmental processes and patterning across tissues\u2014left/right pattern formation, axis specification, EMT in heart development, cartilage morphogenesis, pancreatic and endocrine development, and placental/trophoblast-related formation. This suggests proteins involved in embryogenesis and subsequent organ formation rather than a single molecular function, justifying the label. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3},{"id":"GO:0060707","count":3},{"id":"GO:0003198","count":3}]},{"hash":"1257762725339592437","title":"Long-chain fatty acid and sphingolipid biosynthesis","description":"These proteins are strongly linked to fatty acid and sphingolipid biosynthesis terms: very long-chain fatty acid biosynthesis, long-chain fatty acid biosynthesis, unsaturated fatty acid biosynthesis, fatty acid elongation, and sphingolipid biosynthesis. The presence of pheromone metabolic process and courtship behavior hints at lipid-derived signaling roles in some species, while the vesicle transport terms may reflect lipid trafficking aspects. Overall, the dominant theme is lipid biosynthesis, with supportive trafficking and signaling connections.","confidence":"High","size":17,"edges":135,"triangles":665,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0042761","count":10},{"id":"GO:0030148","count":10},{"id":"GO:0007619","count":9},{"id":"GO:0006892","count":9},{"id":"GO:0006636","count":9}]},{"hash":"1228194551321730414","title":"Unknown","description":"The top GO terms are mixed: immune-related terms (defense response to fungus, killing of cells of another organism, positive regulation of leukocyte tethering) appear alongside development (exocrine pancreas development, midbrain development, post-embryonic development), metabolism (cellular response to glucose stimulus), and transcription regulation. With no consistent shared process across all 17 proteins and no edges/triangles indicating a cohesive interaction, there isn't a clear single theme to label the cluster beyond Unknown.","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050832","count":2},{"id":"GO:0031640","count":1},{"id":"GO:0045944","count":1},{"id":"GO:0031017","count":1},{"id":"GO:1903238","count":1}]},{"hash":"281067579443454044","title":"Ubiquitin-Dependent Protein Degradation","description":"The top GO terms point to ubiquitination and proteasome-mediated turnover (K48-linked ubiquitination, ubiquitin-dependent protein catabolic process, autoubiquitination) with additional links to receptor turnover (Wnt receptor catabolic process) and peroxisomal protein import, which can involve ubiquitin signaling. A few terms are more peripheral (iron response, X inactivation) but can be connected to broader regulatory roles of ubiquitination. Overall, the cluster seems to group proteins involved in tagging and degrading other proteins, especially in signaling and growth contexts.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010039","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0060816","count":1},{"id":"GO:0070936","count":1},{"id":"GO:0038018","count":1}]},{"hash":"1755605273253914011","title":"Unknown","description":"These GO terms cover taste perception, ion transport, male germ-line stem cell maintenance, inflammation regulation, protein hexamerization, ischemia response, foregut morphogenesis, memory, and MAPK signaling modulation. No single theme ties them together, and the cluster has only a single edge with no triangles, indicating a lack of cohesive function. Therefore Unknown with None.","confidence":"","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050913","count":2},{"id":"GO:0006811","count":2},{"id":"GO:0036098","count":2},{"id":"GO:0050717","count":2},{"id":"GO:0050718","count":2}]},{"hash":"1553111300376055633","title":"Diverse solute transmembrane transport","description":"The top GO terms are all about transmembrane transport of a wide range of substrates and ions (nitrate, nitrite, phosphate, potassium, arabinose, xenobiotics, vitamins, etc.), with nitrate assimilation and fucose metabolism also tied to transport processes. This points to a cluster of proteins functioning as membrane transporters handling diverse solutes. ","confidence":"High","size":17,"edges":36,"triangles":27,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":14},{"id":"GO:0071805","count":14},{"id":"GO:0035435","count":14},{"id":"GO:0015751","count":14},{"id":"GO:0006855","count":14}]},{"hash":"21473377209731490","title":"Gut mucosal immunity and secretion","description":"These GO terms cluster around gut-related functions: gastric acid secretion, IgA class switching, eosinophil chemotaxis, platelet activation, regulation of acetylcholine metabolism, xenobiotic response, posterior midgut development, transepithelial chloride transport, and regulation of pain perception. Together they suggest a theme of mucosal defense, secretion, and epithelial transport in the gastrointestinal tract, with some energy metabolism and detoxification processes also represented.","confidence":"Medium","size":17,"edges":7,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001698","count":17},{"id":"GO:0048290","count":17},{"id":"GO:0048245","count":17},{"id":"GO:0030168","count":17},{"id":"GO:0060408","count":17}]},{"hash":"1035368957633013121","title":"Nuclear RNA processing and DNA repair","description":"This cluster is enriched for nucleolar rRNA maturation and transcription terms (5.8S/LSU rRNA processing; rRNA transcription by RNA polymerase I), plus spliceosome-mediated splicing and transcription, indicating a focus on nuclear RNA maturation and processing. It also includes DNA damage response and repair terms (UV-C response, nucleotide-excision repair gap filling, translesion synthesis) and DNA replication, suggesting involvement in genome maintenance. The combination points to a theme of nuclear RNA processing together with DNA repair/replication activities.","confidence":"Medium","size":16,"edges":110,"triangles":442,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0071494","count":3},{"id":"GO:0042276","count":3},{"id":"GO:0070987","count":3}]},{"hash":"1754528562358551177","title":"Mitotic chromosome segregation and RNA processing","description":"This cluster includes GO terms tied to mitosis and chromosome dynamics (spindle orientation checkpoint signaling, centromeric cohesion, septin ring disassembly, chromosome localization) and RNA handling (RNase MRP-dependent processing, snoRNA processing). The common thread appears to be cell-division machinery coordinating chromosome segregation with RNA metabolism and localization, with a few broader terms reflecting general cytoplasmic/nuclear dynamics.","confidence":"Medium","size":16,"edges":71,"triangles":140,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0031578","count":2},{"id":"GO:0000294","count":2},{"id":"GO:0034965","count":2},{"id":"GO:0051754","count":1},{"id":"GO:0090219","count":1}]},{"hash":"1020765622639215587","title":"Immune signaling and cytoskeletal remodeling","description":"The top GO terms are dominated by immune-related processes (innate immune response, B cell proliferation in immune response, Fc-epsilon receptor signaling, platelet degranulation) and cytoskeletal dynamics (actin crosslink formation), suggesting a theme of immune signaling linked to cytoskeletal remodeling. Additional terms touch on mechanotransduction and development (cellular response to mechanical stimulus; bone/heart development; axonogenesis), indicating broader developmental contexts where immune signaling and cytoskeletal changes may intersect. Overall, the label captures the prominent immune/cytoskeletal axis with recognition of developmental ties.","confidence":"Medium","size":16,"edges":22,"triangles":3,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0007409","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0002322","count":3}]},{"hash":"1490729035349785368","title":"DNA Damage Response and Telomere Maintenance","description":"Most top GO terms converge on DNA damage response and telomere biology: telomere maintenance, its negative regulation via recombination, and repair pathways such as classical nonhomologous end joining, along with cellular responses to X-ray and gamma radiation. This combination points to a genome integrity-focused cluster centered on telomere maintenance and DNA repair, with a few terms likely reflecting broader cellular processes. ","confidence":"High","size":16,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032208","count":2},{"id":"GO:0071481","count":2},{"id":"GO:0007535","count":2},{"id":"GO:0060218","count":2},{"id":"GO:0048660","count":2}]},{"hash":"687466887050654582","title":"Spliceosome-regulated RNA processing and ribosome biogenesis","description":"The cluster shows strong enrichment for spliceosome-related terms (mRNA splicing, regulation of alternative splicing, mRNA cis splicing), mRNA stability, and ribosome biogenesis/processome assembly, plus translation-related terms. This points to a cohesive set of RNA processing and ribosome assembly factors acting in RNA maturation and protein synthesis.","confidence":"High","size":16,"edges":117,"triangles":519,"max_degree":15,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0048025","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0010610","count":4},{"id":"GO:0045292","count":4}]},{"hash":"2277249180277284933","title":"Neural and Embryonic Development","description":"The top GO terms cluster around embryogenesis and neural formation, including forebrain development, neural tube closure, and general multicellular organism development, supported by transcription and cell-cycle activity. While there are some stress-related terms present, the dominant signal points to developmental programs, especially neural/embryonic processes, making this an intuitive label.","confidence":"High","size":16,"edges":48,"triangles":52,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030900","count":8},{"id":"GO:0050830","count":8},{"id":"GO:0006349","count":7},{"id":"GO:0000278","count":7},{"id":"GO:0007275","count":7}]},{"hash":"853621306035104314","title":"Cell Cycle Regulation and Development Signaling","description":"The top GO terms cluster around ubiquitin-dependent proteolysis, cell division, and G2/M transition, highlighting cell cycle control. Additional terms like canonical Wnt signaling and various developmental processes (muscle differentiation, mammary gland development) suggest broader signaling links to differentiation and tissue development, with some immune/metabolic contexts (germinal center formation, leptin response). Taken together, the proteins likely coordinate proliferation with developmental signaling and differentiation programs.","confidence":"Medium","size":16,"edges":76,"triangles":161,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0000086","count":3},{"id":"GO:0070527","count":2},{"id":"GO:0035914","count":2}]},{"hash":"1488015595181181255","title":"Unknown","description":"The enriched GO terms span diverse, mostly unrelated processes (DNA repair and telomere maintenance; transcription and tRNA modification; stress responses to nitrogen starvation and cadmium; apoptosis and innate immunity; even tissue development in cardiac muscle). There isn\u2019t a clear common function linking the proteins, so a coherent label isn\u2019t supported.","confidence":"","size":16,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000722","count":2},{"id":"GO:0070525","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0006995","count":2},{"id":"GO:0006281","count":2}]},{"hash":"501299140884897101","title":"Heart and retinal development","description":"The top GO terms are dominated by cardiovascular and visual/retinal development (heart development, visual perception, retina layer formation), suggesting the proteins in this cluster are involved in developmental programs affecting heart and eye tissues. Other terms like G2/M cell cycle transition, protein methylation, and inositol phosphate metabolism hint at broader cellular roles or annotation noise, but the strongest, consistent theme is heart and retina development. ","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0007601","count":13},{"id":"GO:0070886","count":13},{"id":"GO:0010842","count":11},{"id":"GO:1905205","count":11}]},{"hash":"512902790825880212","title":"Autophagy and mitophagy pathways","description":"The top GO terms center on autophagic processes: autophagosome assembly, mitophagy, glycophagy, and CVT (cytoplasm-to-vacuole targeting), plus contexts like ER-stress\u2013induced autophagy and mitochondrial fragmentation in apoptosis. Additional terms about protein lipidation and membrane targeting fit with autophagosome membrane dynamics. A single term about cilium assembly appears minor and does not define the cluster. Overall, the cluster reflects autophagy-related pathways and organelle turnover.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902017","count":1},{"id":"GO:0000422","count":1},{"id":"GO:0006612","count":1},{"id":"GO:0006501","count":1},{"id":"GO:0032258","count":1}]},{"hash":"755693984017358365","title":"Zinc ion transport and homeostasis","description":"This cluster is dominated by GO terms related to importing zinc ions across the plasma membrane and maintaining intracellular zinc homeostasis, including detoxification and response to zinc starvation, indicating the proteins function primarily in zinc transport/homeostasis. While a couple of terms touch on limb development and fertilization, the core signal is zinc ion transport/maintenance, suggesting a coherent functional theme. ","confidence":"High","size":16,"edges":41,"triangles":52,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":3},{"id":"GO:0044749","count":3},{"id":"GO:0034224","count":3},{"id":"GO:0006830","count":3},{"id":"GO:0006882","count":3}]},{"hash":"1009462405258416999","title":"Excitatory synaptic signaling and postsynaptic organization","description":"The dominant terms point to excitatory synaptic activity (positive regulation of EPSP, glutamate secretion, chemical synaptic transmission, NO-mediated retrograde signaling) and structural aspects of the synapse (receptor clustering, actin cytoskeleton organization). Some other terms (microvillus assembly, bile acid secretion, endothelial barrier) appear ancillary or represent broader cellular processes, but the core theme is excitatory neuronal signaling and synaptic architecture.","confidence":"High","size":16,"edges":37,"triangles":66,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2000463","count":14},{"id":"GO:0014047","count":14},{"id":"GO:0030033","count":14},{"id":"GO:0090179","count":14},{"id":"GO:0030036","count":14}]},{"hash":"944258360201968656","title":"Nociception and Thermoception","description":"Dominant GO terms cluster around sensing and responding to temperature and pain (thermoception and various nociception terms), with additional signals related to thermoregulation (brown fat differentiation) and autonomic functions (vasopressin secretion, SA node action potential). This combination points to a coherent theme of detecting thermal/pain stimuli and integrating thermoregulatory responses.","confidence":"High","size":16,"edges":85,"triangles":219,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0050968","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0050960","count":4},{"id":"GO:0048265","count":4},{"id":"GO:0030103","count":4}]},{"hash":"938493768168167298","title":"ERAD and Ubiquitin-SUMO Regulation","description":"The top GO terms cluster around ubiquitination, sumoylation, deubiquitination, and ER-associated degradation (ERAD), including a tail-anchored membrane protein insertion into the ER membrane, which together point to ubiquitin/SUMO-mediated proteostasis at the ER. Several terms are obsolete or less cohesive (e.g., chromosomal DNA methylation, rRNA maturation), but the dominant signal is post-translational modification and ERAD processes. This suggests a cohesive role in tagging and removing misfolded or regulatory proteins via ubiquitin and SUMO pathways within the ER context.","confidence":"High","size":16,"edges":93,"triangles":285,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":10},{"id":"GO:0051865","count":7},{"id":"GO:1903265","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0010216","count":6}]},{"hash":"1523789754099729670","title":"Embryogenesis and tissue morphogenesis","description":"GO terms cluster around left-right patterning, organ development (pancreatic cells, cartilage, placenta), and EMT in heart development, indicating a developmental morphogenesis program during embryogenesis. Some terms related to basic processes (DNA repair, splicing) are supplementary, but the dominant signal is embryonic tissue patterning and morphogenesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0003198","count":2}]},{"hash":"611445246714486555","title":"Neural development and brain regionalization","description":"The top GO terms focus on neural development and regional specification (cerebral cortex regionalization, spinal cord neuron differentiation, forebrain neuronal commitment, habenula and pituitary development) with additional morphogenesis signals (roof of mouth, cochlea). This points to a cohesive developmental program centered on neural patterning and brain region specification, with some cross-tissue morphogenesis context.","confidence":"High","size":16,"edges":60,"triangles":108,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":6},{"id":"GO:0090190","count":6},{"id":"GO:0023019","count":6},{"id":"GO:0021986","count":6},{"id":"GO:0021902","count":6}]},{"hash":"1570125277903434556","title":"PSD-95 Synaptic Localization and Regulation","description":"The top GO terms point to localization to microtubules and regulation of PSD-95 clustering, both tying to synaptic organization and trafficking of scaffold proteins. With only single-term hits and no observed interactions, the signal is weak, so the label is provisional but thematically coherent for a neuronal synapse-focused cluster.","confidence":"Low","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035372","count":1},{"id":"GO:1902897","count":1}]},{"hash":"465918548307217449","title":"Mitotic spindle assembly and microtubule nucleation","description":"Most top GO terms describe microtubule nucleation and spindle formation (spindle pole body, gamma-tubulin complex localization, mitotic spindle assembly, interphase MTOC), suggesting the cluster\u2019s proteins are involved in assembling the mitotic spindle and organizing microtubules. A few terms reference immune signaling and stress responses, which appear as separate annotations and do not redefine the main theme. Overall, the dominant function theme is spindle assembly and microtubule nucleation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051417","count":1},{"id":"GO:0033566","count":1},{"id":"GO:0051415","count":1},{"id":"GO:0090307","count":1},{"id":"GO:0033209","count":1}]},{"hash":"511749096698706259","title":"Rho/Rac-driven actin remodeling and receptor trafficking","description":"These proteins cluster around cytoskeletal dynamics and membrane trafficking: regulation of Rho and Rac signaling, filopodium assembly, actomyosin organization, integrin activation, and recycling pathways (receptor and endocytic). The presence of axonogenesis hints at neuronal contexts, but the core theme is coordinated actin remodeling with trafficking and adhesion processes. ","confidence":"High","size":16,"edges":15,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0001881","count":2},{"id":"GO:0032456","count":2},{"id":"GO:0048936","count":2}]},{"hash":"1247346770698146796","title":"Nucleocytoplasmic Transport","description":"The top GO terms cluster around transport into and out of the nucleus and through the nuclear pore, including protein import into the nucleus, protein export from the nucleus, nuclear pore localization, and poly(A)+ mRNA export. A few terms reference vesicle transport (Golgi to ER), but the dominant theme is nucleocytoplasmic trafficking and nuclear pore\u2013associated transport.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006810","count":2},{"id":"GO:0071806","count":1},{"id":"GO:2000156","count":1},{"id":"GO:1904046","count":1},{"id":"GO:0042307","count":1}]},{"hash":"948275922337228246","title":"Innate and Adaptive Immune Activation","description":"The top GO terms indicate broad immune activation, including phagocytosis (recognition and engulfment), innate immune response, complement activation, and production of inflammatory mediators, together with B and T cell activation and B cell receptor signaling. This pattern points to a cluster of proteins involved in coordinated immune activation spanning both innate and adaptive immunity and inflammatory signaling.","confidence":"High","size":16,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090197","count":3},{"id":"GO:0075015","count":2},{"id":"GO:0050871","count":2},{"id":"GO:0006910","count":2},{"id":"GO:0006958","count":2}]},{"hash":"34352732482701306","title":"Neural development and sensory organogenesis","description":"The top GO terms cluster around neural development and signaling: myelination, axonal fasciculation, positive regulation of synapse assembly, and ERK pathway signaling (including ERK cascade and adenosine receptor signaling). Several terms also point to sensory organ formation, such as otolith morphogenesis and organ induction, suggesting inner ear development as part of the theme. A few terms relate to innate immunity or lymphoid differentiation, which are less central to the core theme and may reflect annotation overlap or secondary roles. Overall, the cluster aligns best with neural development and sensory organogenesis.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042552","count":5},{"id":"GO:0014068","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0032474","count":4},{"id":"GO:0051965","count":4}]},{"hash":"2240456015440021584","title":"Insect pheromone signaling and ecdysis regulation","description":"This cluster is driven by GO terms for pheromone response, smell perception, social behavior, and neuropeptide signaling, along with developmental processes like eclosion and ecdysis, pointing to an insect-wide theme of chemical communication and molting-related regulation. A few terms (transport, defense to Gram-positive bacteria) are less central, but the core terms strongly suggest insect pheromone signaling and developmental regulation.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0018298","count":1}]},{"hash":"860752301485941148","title":"Developmental Morphogenesis and Neural Signaling","description":"The cluster combines development-related processes (body morphogenesis, chitin-based cuticle development, glomerulus development) with neural signaling functions (GABA signaling, chemical synaptic transmission, calcium ion transport, IGF receptor signaling). This suggests proteins that coordinate tissue formation with neural communication, potentially in an insect context given the cuticle term; egg activation and reproduction terms appear but are less central to the core theme.","confidence":"Medium","size":16,"edges":23,"triangles":16,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":3},{"id":"GO:0040003","count":3},{"id":"GO:0032504","count":2},{"id":"GO:0007343","count":1},{"id":"GO:1900122","count":1}]},{"hash":"1385750034693614080","title":"Iron uptake and homeostasis","description":"The cluster is dominated by GO terms related to iron handling, including transferrin transport, iron ion import across the plasma membrane, and intracellular iron ion homeostasis, with receptor-mediated endocytosis providing a mechanistic link to iron uptake. While other terms appear less connected, the iron-related terms form the clearest common theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033572","count":1},{"id":"GO:0006879","count":1},{"id":"GO:0042135","count":1},{"id":"GO:0010081","count":1},{"id":"GO:0035609","count":1}]},{"hash":"1030207348305662701","title":"Developmental and Innate Immune Signals","description":"Most proteins in this cluster map to innate immune and inflammatory processes: leukocyte tethering/rolling, phagocytosis recognition, complement activation (lectin pathway), and regulation of NK cell chemotaxis, along with platelet activation and oxidative stress-related senescence. There are also developmental terms (cartilage condensation, mesonephric duct development) and a broader response to fungal-origin molecules, suggesting a signaling network that spans development and immune response. This justifies a label that reflects both themes, though the predominance of immune-related terms makes the assignment somewhat tentative. ","confidence":"Medium","size":16,"edges":18,"triangles":4,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0090238","count":14},{"id":"GO:0050901","count":14},{"id":"GO:0072177","count":14}]},{"hash":"2196862931194654700","title":"Embryonic organ morphogenesis","description":"The proteins are enriched for diverse embryonic development terms, spanning craniofacial structures (roof of mouth, cranial skeleton, dentin/odontogenesis), neural development (neural crest migration, hypothalamus, habenula), and other organ morphogenesis (digestive tract, ureteric bud). This coherent theme points to a cluster of factors involved in broad embryonic organ formation rather than a single tissue-specific function.","confidence":"High","size":16,"edges":107,"triangles":456,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060021","count":10},{"id":"GO:0001755","count":9},{"id":"GO:0007519","count":8},{"id":"GO:0048701","count":8},{"id":"GO:0090190","count":8}]},{"hash":"1785390570511869122","title":"Peptidoglycan and chitin cell wall metabolism","description":"The proteins cluster around cell wall-related processes: biosynthesis and catabolism of peptidoglycan, chitin catabolic processes, and regulation of cell shape, with sporulation also represented. This points to a shared theme of cell wall biosynthesis and remodeling across different organisms, despite one outlier term that may represent noise (viral transport). Thus, the label captures the core function of cell wall metabolism driven by peptidoglycan and chitin pathways.","confidence":"Medium","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":1},{"id":"GO:0009252","count":1},{"id":"GO:0008360","count":1},{"id":"GO:0009253","count":1},{"id":"GO:0071323","count":1}]},{"hash":"90051220341200110","title":"Embryonic organogenesis and innate immune signaling","description":"The top GO terms point to organ development processes (metanephric glomerulus, bone, lymph vessel morphogenesis) alongside broad signaling pathways (receptor tyrosine kinase signaling, TLR signaling) and immune responses (response to lipopolysaccharide). This suggests a cluster of proteins involved in developmental morphogenesis with concurrent roles in innate immune signaling. Confidence: Medium","confidence":"","size":16,"edges":44,"triangles":45,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0072224","count":14},{"id":"GO:0090260","count":14},{"id":"GO:0007169","count":14},{"id":"GO:0071222","count":14},{"id":"GO:0002091","count":14}]},{"hash":"2044977969596165316","title":"Developmental signaling and ECM remodeling","description":"The top GO terms cluster around development-related processes (embryo implantation, spermatogenesis, kidney development, male germ cell proliferation) and regulation of signaling pathways (negative regulation of BMP and activin receptor signaling), with extracellular matrix organization and receptor clustering indicating coordinated ECM remodeling during development. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0007596","count":5},{"id":"GO:0032926","count":3},{"id":"GO:0002176","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0007566","count":3}]},{"hash":"1310093736924112755","title":"GABAergic Inhibitory Synaptic Transmission and Modulation","description":"This cluster is dominated by terms related to inhibitory signaling and postsynaptic organization, especially GABA signaling and receptor clustering, along with components of inhibitory postsynaptic potentials. The presence of dopaminergic, cholinergic, and adrenergic modulation terms (e.g., regulation of norepinephrine secretion and nicotine response) suggests a broader synaptic regulation context, but the core function centers on GABA-mediated inhibition and its impact on neuronal excitability and synaptic transmission.","confidence":"High","size":16,"edges":113,"triangles":483,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060080","count":15},{"id":"GO:1901214","count":15},{"id":"GO:0032226","count":15},{"id":"GO:0001941","count":15},{"id":"GO:0007214","count":15}]},{"hash":"604654253937242886","title":"Developmental transcriptional regulation","description":"The top GO terms cluster around transcriptional regulation by RNA polymerase II and developmental processes (exocrine pancreas development, midbrain development, post-embryonic development), with additional immune signaling and metabolic response terms as secondary themes. This combination best captures the dominant functions represented, despite some outlier terms.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":16},{"id":"GO:0031017","count":16},{"id":"GO:1903238","count":16},{"id":"GO:0051919","count":16},{"id":"GO:0030901","count":16}]},{"hash":"2116942268778921140","title":"Lipid transport and innate immune signaling","description":"The top GO terms show strong enrichment for lipid handling (lipoprotein transport, HDL remodeling, reverse cholesterol transport, long-chain fatty acid import) alongside immune/inflammatory terms (immune response, IL-6 production, NLRP3 inflammasome regulation, LPS detection, oxidative stress response). This suggests a theme where lipid metabolism interacts with innate immune pathways, possibly in cells like macrophages or hepatocytes; the rhodopsin-related term appears incidental. Overall, the cluster seems to capture cross-talk between lipid transport/metabolism and inflammatory signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006955","count":3},{"id":"GO:0016063","count":3},{"id":"GO:0042953","count":2},{"id":"GO:0032755","count":2},{"id":"GO:0043691","count":2}]},{"hash":"53225540558333893","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990569","count":3},{"id":"GO:0034221","count":2},{"id":"GO:0046963","count":2},{"id":"GO:1990034","count":2},{"id":"GO:0072334","count":2}]},{"hash":"1286721496719030408","title":"GABAergic, dopaminergic, and cholinergic synaptic regulation","description":"The top GO terms converge on inhibitory signaling (IPSPs, GABA pathway, GABA receptor clustering) and modulatory neurotransmission (dopaminergic, cholinergic, norepinephrine, nicotine response), indicating proteins that regulate synaptic transmission across multiple neurotransmitter systems.","confidence":"High","size":16,"edges":118,"triangles":532,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060080","count":16},{"id":"GO:1901214","count":16},{"id":"GO:0032226","count":16},{"id":"GO:0007214","count":16},{"id":"GO:0035094","count":16}]},{"hash":"1818738366735137797","title":"Developmental morphogenesis and signaling","description":"The GO terms include embryonic tissue morphogenesis (face development), cell migration, vesicle trafficking and exocytosis, and signaling pathway regulation (Rac, calcium-dependent exocytosis), as well as modulation of apoptosis and neural plasticity. Together these suggest a coherent theme of developmental morphogenesis and coordinated cell signaling, rather than a single functional category.","confidence":"Medium","size":15,"edges":57,"triangles":108,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0045956","count":4},{"id":"GO:0032495","count":4},{"id":"GO:0031914","count":3},{"id":"GO:0060324","count":3}]},{"hash":"2174456132919171946","title":"Nuclear transcription, RNA processing, and chromatin regulation","description":"This cluster combines GO terms centered on nuclear gene expression: transcription termination of RNA polymerase II, histone mRNA metabolism, splicing, rRNA maturation, and chromatin/heterochromatin formation, along with nuclear import and mRNA decapping. The presence of ABA/water-deprivation responses may reflect stress-linked chromatin shifts or annotation overlap, but the core pattern is nuclear regulation of transcription and RNA processing.","confidence":"High","size":15,"edges":101,"triangles":409,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0008334","count":13},{"id":"GO:0006369","count":13},{"id":"GO:1990141","count":13},{"id":"GO:0009737","count":13},{"id":"GO:0051170","count":13}]},{"hash":"1376031839890521107","title":"Ribosome Biogenesis and Mitosis","description":"This cluster is driven by strong signals for ribosomal RNA processing and large subunit biogenesis (5.8S rRNA maturation, LSU rRNA maturation) alongside multiple mitosis-related terms (mitotic cell cycle, cell division, homologous chromosome segregation, and mitosis-associated DNA replication processing). The combination suggests proteins involved in assembling ribosomes while coordinating cell cycle progression and chromosome dynamics, with some chromatin-related regulation hints (histone methylation, monoubiquitination). Thus the label reflects two linked functional themes present in the cluster.","confidence":"High","size":15,"edges":99,"triangles":385,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042273","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0000466","count":6},{"id":"GO:0000463","count":6}]},{"hash":"359648201234089506","title":"Spliceosome Regulation and Mitotic Chromatin Dynamics","description":"The top GO terms are centered on mRNA splicing and its regulation via the spliceosome, with additional signals for mitotic processes and chromatin assembly (CENP-A centromeric assembly) and microtubule-related activities. This pattern suggests a cluster of proteins involved in RNA processing that also interfaces with chromosome maintenance and mitosis, indicating a shared role in coordinating gene expression with cell division and chromatin dynamics.","confidence":"Medium","size":15,"edges":102,"triangles":416,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0048024","count":3},{"id":"GO:0010610","count":3}]},{"hash":"183973800432933367","title":"Unknown","description":"The top GO terms are very diverse, including oxidation-reduction, nuclear import, adherens junction assembly, digestion, insulin and calcium signaling, retinoid metabolism, Rab signaling, and intraciliary transport. There is no single coherent biological function tying these together, so no meaningful cluster label can be assigned beyond Unknown.","confidence":"","size":15,"edges":6,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0006607","count":2},{"id":"GO:0034333","count":2},{"id":"GO:0007586","count":2},{"id":"GO:0032869","count":2}]},{"hash":"1372333171172266112","title":"Notch-driven epidermal differentiation and vesicle trafficking","description":"The cluster centers on Notch signaling and keratinocyte differentiation, indicating a skin-differentiation program. It is complemented by vesicle trafficking and protein sorting processes (multivesicular body/ exosome assembly, ubiquitin-dependent pathways, and protein transport), which are key in Notch receptor processing and endosomal signaling, supporting a cohesive module around Notch-regulated epidermal differentiation and associated trafficking. ","confidence":"High","size":15,"edges":84,"triangles":270,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030216","count":2},{"id":"GO:0007219","count":2},{"id":"GO:0031018","count":2},{"id":"GO:0043162","count":1},{"id":"GO:0036258","count":1}]},{"hash":"1347012143179255353","title":"RNA splicing and translation initiation","description":"The top GO terms cluster around mRNA splicing, spliceosome regulation, mRNA stabilization, and small-subunit processome assembly, with additional references to translation initiation (eIF4F complex assembly). This points to a group of proteins involved in post-transcriptional mRNA processing and the initiation of translation, rather than a single metabolic pathway. Confidence: Medium","confidence":"","size":15,"edges":91,"triangles":364,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006376","count":5},{"id":"GO:0048255","count":4},{"id":"GO:0034462","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0000381","count":4}]},{"hash":"180702444461175551","title":"Stress-Response and Translational Regulation","description":"The cluster shows enrichment for cellular stress-related processes, including cellular response to UV-C, DNA damage checkpoint signaling, and regulation of cytoplasmic translation and translational initiation in response to stress or starvation. Additional terms on vesicle transport and RNA processing hint at broader coordinated stress responses affecting signaling, RNA processing, and protein synthesis control.","confidence":"Medium","size":15,"edges":72,"triangles":180,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0000245","count":1},{"id":"GO:0071494","count":1},{"id":"GO:0000077","count":1},{"id":"GO:0097201","count":1}]},{"hash":"1844830269875828671","title":"Mitochondria-driven apoptosis and antiviral response","description":"The top GO terms cluster around regulation of apoptotic signaling via mitochondria, including outer membrane permeabilization and mitochondrial fission, suggesting a core role in mitochondria-mediated apoptosis. In addition, terms related to antiviral and innate immune signaling (response to dsRNA, defense response to virus, T cell chemotaxis) indicate an immune dimension that often intersects with apoptosis in cellular defense. A few terms like eye development are less directly connected and may reflect broader or incidental annotations. Overall, the set points to proteins involved in mitochondrial apoptosis with concurrent antiviral/immune signaling roles, justifying the chosen label.","confidence":"Medium","size":15,"edges":46,"triangles":34,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2001241","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0090141","count":1},{"id":"GO:0090314","count":1},{"id":"GO:1901028","count":1}]},{"hash":"1421288863883820523","title":"Cellular Stress Response to Environmental Stressors","description":"The cluster is dominated by GO terms related to oxidative stress (response to hydrogen peroxide, ROS regulation), heat, light, and radiation responses, suggesting a common role in protecting cells from environmental stress and coordinating stress signaling. Some terms like lens fiber morphogenesis and axonal transport may be additional context-specific roles but do not negate the central stress-response theme.","confidence":"High","size":15,"edges":89,"triangles":288,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042542","count":9},{"id":"GO:0071480","count":9},{"id":"GO:0070309","count":8},{"id":"GO:0007568","count":8},{"id":"GO:0006936","count":8}]},{"hash":"2237150779095375542","title":"Organelle Translation and Gene Expression","description":"The cluster shows strong signals for mitochondrial translation, ribosome assembly, and transcription, plus regulation of mitochondrial transcription and chloroplast organization, indicating a coherent set of proteins involved in organellar gene expression. The inclusion of plastid-related processes such as farnesyl diphosphate biosynthesis supports plastid metabolism, linking organellar gene expression to plastid function.","confidence":"High","size":15,"edges":103,"triangles":430,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0045337","count":2},{"id":"GO:0006915","count":1},{"id":"GO:0032543","count":1}]},{"hash":"963540349383974213","title":"Nucleotide Metabolism and Phosphorylation","description":"The cluster is dominated by GO terms for nucleotide phosphorylation and biosynthesis (ADP, CDP, AMP salvage, ITP) and phosphorylation events, with sulfate assimilation also linked to related metabolism. A couple of development terms (liver/brain) may reflect tissue expression rather than core function. Overall, the coherent theme is nucleotide metabolism and phosphate turnover, justifying this label.","confidence":"Medium","size":15,"edges":93,"triangles":320,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0000103","count":4},{"id":"GO:0016310","count":4},{"id":"GO:0046939","count":4},{"id":"GO:0046940","count":4},{"id":"GO:0006172","count":3}]},{"hash":"1855360830677866628","title":"Proteolysis and Antigen Processing with Angiogenesis","description":"GO terms indicate coordinated regulation of proteolysis (endopeptidase activity and proteasomal catabolic process) combined with antigen processing/presentation, pointing to immune handling of proteins and peptides. The presence of angiogenesis-related regulation suggests involvement in vascular remodeling, potentially linking proteolysis and immune signaling to vessel growth. Despite a few obsolete terms, the dominant theme is proteolysis-linked antigen processing with a vascular remodeling aspect, justifying this label.","confidence":"High","size":15,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010950","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0019509","count":2}]},{"hash":"1273096153051878570","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":79,"triangles":226,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":14},{"id":"GO:0055114","count":14},{"id":"GO:0009718","count":13},{"id":"GO:0006012","count":13},{"id":"GO:0009243","count":13}]},{"hash":"1144626551200406414","title":"Amino acid and fatty acid catabolism with energy metabolism","description":"This cluster is dominated by catabolic processes of branched-chain amino acids (leucine and valine) and fatty acids (medium-chain) and the associated carnitine biosynthesis/metabolism, plus a general response to starvation. These terms point to an energy-generation theme (amino acid and fatty acid oxidation, carnitine-mediated transport) that can underlie broader developmental processes. The presence of a few outliers (e.g., ascaroside biosynthesis, obsolete terms) introduces some noise, but the core signal is metabolic energy production. ","confidence":"Medium","size":15,"edges":68,"triangles":154,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0006552","count":8},{"id":"GO:0006574","count":8},{"id":"GO:0045329","count":7},{"id":"GO:0042594","count":7}]},{"hash":"557160171071710390","title":"Chromatin Dynamics and Cell Cycle Regulation","description":"This cluster centers on processes linking chromatin state and transcription with cell cycle control and nuclear transport: G1/S transition, mitotic centrosome separation, SMAD signaling, nuclear import, and chromatin-related activities (including chromatin silencing and transcriptional puffing). While some terms are obsolete, the prevailing theme is coordination of chromatin dynamics with cell cycle progression and nuclear trafficking.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000042","count":2},{"id":"GO:0000061","count":2},{"id":"GO:0007184","count":2},{"id":"GO:0046604","count":2},{"id":"GO:0035392","count":2}]},{"hash":"1486289646955276646","title":"Unknown","description":"The top GO terms span metabolism (glucose response), transcription regulation, developmental programs (exocrine pancreas, midbrain, post-embryonic), immune processes (leukocyte tethering/rolling, chemokine regulation), fibrinolysis, and signaling. This diversity suggests no single cohesive function links all proteins, so a specific, high-confidence label cannot be assigned.","confidence":"","size":15,"edges":22,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":7},{"id":"GO:0045944","count":6},{"id":"GO:0031017","count":6},{"id":"GO:1903238","count":6},{"id":"GO:0051919","count":6}]},{"hash":"1850812372857744204","title":"RNA and Protein Methyltransferases","description":"The top GO terms are dominated by methylation activities: RNA methylation (guanine-N7, rRNA, tRNA, mRNA capping) and peptidyl-arginine methylation, with an additional histone methylation term. This pattern points to a cluster of methyltransferase enzymes acting on both RNA and protein substrates, making this a coherent functional group despite a few broader terms. ","confidence":"High","size":15,"edges":41,"triangles":37,"max_degree":12,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0036265","count":8},{"id":"GO:0019919","count":8},{"id":"GO:0006370","count":8},{"id":"GO:0009236","count":8},{"id":"GO:0016049","count":7}]},{"hash":"568238096156672954","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":84,"triangles":259,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0046444","count":4},{"id":"GO:1990966","count":4},{"id":"GO:0034628","count":4},{"id":"GO:0006747","count":4},{"id":"GO:0009611","count":4}]},{"hash":"1144080103741273867","title":"Methionine salvage and threonine biosynthesis with antibiotic response","description":"The cluster shows strong representation of methionine salvage (two GO terms) and L-threonine biosynthesis, each with high counts, plus a clear signal for response to antibiotic. These indicate a cohesive theme around amino acid metabolism and antimicrobial stress response, with phosphorylation and a minor methylation term as supporting regulatory features. ","confidence":"High","size":15,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":10},{"id":"GO:0046677","count":10},{"id":"GO:0009088","count":10},{"id":"GO:0019284","count":10},{"id":"GO:0016310","count":10}]},{"hash":"103629954857082162","title":"Glycinergic transmission and amino acid transport","description":"This cluster centers on glycine handling and signaling (glycine secretion, import, and glycinergic synaptic transmission) and includes transport of various amino acids (leucine, proline, taurine). The common theme is neurotransmitter signaling with a strong emphasis on glycine alongside general amino acid transport, suggesting a cohesive role in synaptic transmission and amino acid transport mechanisms.","confidence":"High","size":15,"edges":69,"triangles":134,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":7},{"id":"GO:0051610","count":7},{"id":"GO:0061537","count":7},{"id":"GO:1905847","count":7},{"id":"GO:0021984","count":7}]},{"hash":"1447536883072075103","title":"Ubiquitin-Dependent Regulation Across Tissues","description":"The top GO terms center on ubiquitin-related processes (negative regulation of protein ubiquitination, ubiquitin-dependent protein catabolic process, and K33-linked ubiquitination), which suggests a core theme of ubiquitin-regulated signaling. The other terms reference development and immune signaling in various tissues (muscle, kidney, and immune system), implying these proteins participate in ubiquitin-regulated pathways across different contexts. This supports a label focused on ubiquitin-mediated regulation with cross-tissue roles.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031397","count":2},{"id":"GO:0072156","count":2},{"id":"GO:1990390","count":2},{"id":"GO:2000312","count":2},{"id":"GO:0048741","count":2}]},{"hash":"1346929351878333829","title":"Chromatin regulation and transcription control","description":"This cluster largely centers on chromatin modification and transcription-related processes (deneddylation, desumoylation, negative regulation of chromatin binding, and DNA-templated transcription elongation), with a couple placental development terms that may reflect tissue-specific contexts. The dominant theme across the GO terms is regulation of chromatin state and transcription, rather than a single metabolic or signaling pathway, supporting a label focused on chromatin and transcription control.","confidence":"Medium","size":15,"edges":27,"triangles":17,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060711","count":1},{"id":"GO:0010724","count":1},{"id":"GO:0000338","count":1},{"id":"GO:0032875","count":1},{"id":"GO:0060712","count":1}]},{"hash":"1393400220078194269","title":"Developmental Gene Regulation","description":"The proteins cluster around developmental processes across multiple tissues (antennal, photoreceptor, hair follicle placode, renal vesicle) and also show transcriptional regulation (DNA-templated transcription and its regulation). The mixture suggests a set of factors involved in controlling gene expression during development, even though a few terms touch broader cellular or physiological processes.","confidence":"Medium","size":15,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007349","count":2},{"id":"GO:0006351","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006355","count":1}]},{"hash":"1545624401254049614","title":"Pheromone- and Smell-Driven Social Behavior","description":"The most represented GO terms are response to pheromone, sensory perception of smell, social behavior, and larval feeding behavior, pointing to a cluster of proteins involved in chemosensory signaling and behavior regulation. Other terms like PI3K/AKT signaling and STAT phosphorylation hint at shared signaling pathways, while a few terms (bone mineralization, myoblast differentiation, lipid metabolism) could reflect broader roles. Overall, the theme is chemosensory cues shaping behavior.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":2},{"id":"GO:0007608","count":2},{"id":"GO:0006810","count":2},{"id":"GO:0035176","count":2},{"id":"GO:0035630","count":1}]},{"hash":"1828813170035053521","title":"Unknown","description":"Top terms span development, coagulation, and broad regulatory processes with no single cohesive function; lacking a unifying theme or interactions, no specific label can represent the cluster.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":6},{"id":"GO:0045944","count":5},{"id":"GO:0031017","count":5},{"id":"GO:1903238","count":5},{"id":"GO:0051919","count":5}]},{"hash":"1885889726589467906","title":"Sensory and Cardiac Signaling","description":"The terms point to signaling roles in sensory systems (pheromone detection, auditory receptor development, presynaptic organization) and cardiac excitability (AV node action potential), with supporting intracellular signaling (ERK cascade, adenosine receptor signaling). Although some terms touch on development in other organs, the strongest common theme is signaling in excitable or sensory contexts.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0001812","count":2},{"id":"GO:0097090","count":2},{"id":"GO:0060168","count":2},{"id":"GO:0070374","count":2}]},{"hash":"425151600625751929","title":"Pheromone sensing and circadian regulation in insects","description":"The top GO terms point to pheromone detection and response, along with sleep and circadian regulation (circadian sleep/wake cycle, rhythmic process) and cholinergic synaptic transmission, suggesting a neuronal module focused on olfactory signaling and circadian behavioral control in insects. Some development-related terms (cuticle biosynthesis, tracheal tube regulation) appear but are likely secondary. Overall, the cluster seems best described by pheromone sensing and circadian regulation in insects.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:1903049","count":1},{"id":"GO:1903818","count":1},{"id":"GO:0008362","count":1},{"id":"GO:0035158","count":1}]},{"hash":"753411502774333464","title":"Rho/Rac signaling in development","description":"Several top GO terms point to activation and regulation of small GTPases (Rac, Rho) and related signal transduction, alongside morphogenesis in multiple tissues (midbrain, cardiac structures, pericardium). The common thread is cytoskeletal signaling guiding tissue morphogenesis via Rho/Rac pathways, rather than a single organ-specific process.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033089","count":2},{"id":"GO:1904693","count":2},{"id":"GO:2000973","count":2},{"id":"GO:0003209","count":2},{"id":"GO:0035022","count":2}]},{"hash":"1007982038395703244","title":"ERAD and ER-to-Golgi trafficking","description":"This cluster is driven by terms related to endoplasmic reticulum quality control and secretory pathway transport: ER-associated degradation (ERAD), and ER-to-Golgi vesicle transport. While other terms (like immune signaling) appear, the strongest signals point to a cohesive theme around protein processing and trafficking through the secretory pathway, with possible connections to ER stress responses during infection.","confidence":"Medium","size":15,"edges":102,"triangles":417,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0031664","count":1}]},{"hash":"1003608131374035027","title":"Neural axon guidance and migration","description":"This cluster\u2019s GO terms cluster around neural development, especially axon guidance (retinal ganglion cell and corticospinal axon guidance, axon extension) and neuronal migration (tangential migration from SVZ to the olfactory bulb). Inflammatory and cortisol-response terms may reflect regulatory contexts in CNS development, but the dominant theme is axon pathfinding and migration in neural development.","confidence":"High","size":15,"edges":17,"triangles":7,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0090260","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0021972","count":2},{"id":"GO:0050929","count":2}]},{"hash":"169491454279938348","title":"Membrane transporters for sugars and ions","description":"Top GO terms indicate multiple transmembrane transport activities for D-glucose, D-xylose, nitrate, potassium, selenite, and sodium-dependent organic cations, along with cellular responses to osmotic stress and glucose starvation. Together these point to a cluster of transporter proteins responsible for uptake and homeostasis of sugars and ions in the membrane, indicating a cohesive function in membrane transport and osmoregulation.","confidence":"High","size":15,"edges":51,"triangles":98,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":13},{"id":"GO:0015706","count":12},{"id":"GO:0060731","count":12},{"id":"GO:0071805","count":12},{"id":"GO:0006970","count":12}]},{"hash":"395096012084664120","title":"Reproductive Vascular Remodeling and Immune Signaling","description":"This cluster appears to group proteins involved in pregnancy-associated vascular remodeling and immune signaling, with related development and stress-response processes (angiogenesis, uterine contraction, blood pressure, kidney development, NO and EGFR signaling, cytokine production, inflammatory response).","confidence":"Medium","size":15,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045742","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0050663","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0045777","count":2}]},{"hash":"1861100914834814251","title":"Postsynaptic signaling and synapse organization","description":"The top GO terms cluster around regulation and assembly of excitatory synapses, modulation of postsynaptic potentials, and receptor trafficking, plus neuron\u2013neuron adhesion\u2014traits pointing to a module governing postsynaptic signaling and synapse structure. Additional terms related to ECM and metabolism may reflect remodeling contexts but do not overpower the central postsynaptic theme. Overall, these functions suggest a cohesive role in constructing and regulating the postsynaptic site and synaptic transmission.","confidence":"High","size":15,"edges":32,"triangles":33,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0090394","count":4},{"id":"GO:0097151","count":4},{"id":"GO:0016042","count":4},{"id":"GO:0030199","count":4}]},{"hash":"1309131401851963952","title":"Complement activation, angiogenesis, and coagulation/lipid regulation","description":"Top GO terms point to immune complement pathways (lectin and classical), angiogenesis, plasminogen activation and fibrinolysis, and lipid metabolism, suggesting a cluster tying immune activation to vascular remodeling and clot/lipid regulation.","confidence":"Medium","size":15,"edges":68,"triangles":145,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":4},{"id":"GO:0045766","count":3},{"id":"GO:0031639","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0014068","count":3}]},{"hash":"67303138198999198","title":"N-linked glycosylation and glycoprotein processing","description":"The top GO terms are dominated by N-linked glycosylation, glycan processing, and deglycosylation, with multiple entries specifically pointing to protein glycosylation via asparagine and related maturation steps. The inclusion of rhodopsin biosynthetic process supports a role in glycoprotein maturation in the secretory pathway, suggesting the cluster centers on glycosylation-related protein processing.","confidence":"High","size":15,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0035010","count":7},{"id":"GO:0006013","count":6},{"id":"GO:0006491","count":6},{"id":"GO:0006486","count":6},{"id":"GO:0006517","count":6}]},{"hash":"159551243981879764","title":"Insect circadian sleep and neural signaling","description":"This cluster shows repeated enrichment for sleep and circadian rhythm terms, rhythmic processes, and regulation of cholinergic synaptic transmission and ion-channel activity, pointing to coordinated circadian control of neural signaling in insects. While a couple of terms relate to insect-specific development (cuticle biosynthesis, tracheal tube regulation), the core pattern centers on circadian-sleep regulation and neural communication.","confidence":"Medium","size":15,"edges":38,"triangles":32,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1903049","count":2},{"id":"GO:1903818","count":2},{"id":"GO:0008362","count":2},{"id":"GO:0035158","count":2},{"id":"GO:0030431","count":2}]},{"hash":"395680883227712956","title":"Collagen ECM remodeling with immune and neural development cues","description":"The top GO terms point to extracellular matrix organization (collagen fibril), immune functions (complement activation pathways, defense to bacteria, leukocyte adhesion/rolling), and neural development processes (axonal fasciculation, oligodendrocyte differentiation), suggesting a cluster centered on ECM remodeling intertwined with immune activity and neural differentiation cues.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030199","count":6},{"id":"GO:0006958","count":5},{"id":"GO:0035987","count":5},{"id":"GO:0050901","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1137933559147776842","title":"Developmental morphogenesis and cytoskeletal signaling","description":"Top terms indicate morphogenesis across multiple tissues (midbrain, cardiac atrium, imaginal disc) and cytoskeletal regulation (filopodium assembly, stress fiber assembly, Rac signaling). The mitotic spindle assembly term adds a cell-cycle angle common in developmental contexts. Together, these suggest a cohesive theme of developmental morphogenesis governed by cytoskeletal dynamics and signaling, with some differentiation-related processes represented as well.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0007480","count":2},{"id":"GO:0043314","count":2},{"id":"GO:1904693","count":2},{"id":"GO:2000973","count":2}]},{"hash":"962863718829795255","title":"Cardiac electrophysiology and ion channel regulation","description":"The top GO terms cluster around AV-node action potentials, heart-rate regulation, and membrane potential changes (depolarization/hyperpolarization) with potassium transport, pointing to proteins involved in cardiac electrophysiology and ion-channel regulation. Minor terms on circadian rhythm or nociception are likely incidental.","confidence":"High","size":15,"edges":63,"triangles":114,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0060081","count":3},{"id":"GO:0048016","count":2},{"id":"GO:0086016","count":2},{"id":"GO:0008627","count":2},{"id":"GO:1902303","count":2}]},{"hash":"268815544052634700","title":"Neural crest-driven axon guidance","description":"These proteins cluster around neural crest\u2013derived peripheral nervous system development, with multiple GO terms pointing to neural crest migration (ventral trunk neural crest), various axon guidance events (semaphorin-plexin signaling, branchiomotor neuron and trigeminal nerve guidance, axonal fasciculation), and processes related to myelination and neuronal projections (sympathetic neuron projection extension). The presence of kidney development is an outlier in the GO set, but the dominant signals describe an axon guidance and peripheral nerve formation theme.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001822","count":5},{"id":"GO:0036486","count":5},{"id":"GO:0042552","count":5},{"id":"GO:0097490","count":5},{"id":"GO:1902287","count":5}]},{"hash":"1506214044300111738","title":"Developmental Muscle Formation and Cytoskeletal Assembly","description":"The cluster shows proteins associated with muscle-related structural assembly (muscle thin filament and cardiac thin filament assembly, regulation of myofibril size) alongside broader developmental processes (multicellular organism development, pole cell formation, oskar mRNA localization). Although one term relates to larval cuticle development, the overall pattern points to developmental roles with a focus on muscle architecture and cytoskeletal organization.","confidence":"Medium","size":15,"edges":47,"triangles":50,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":4},{"id":"GO:0007275","count":1},{"id":"GO:0014881","count":1},{"id":"GO:0071689","count":1},{"id":"GO:0045856","count":1}]},{"hash":"2045149823944499710","title":"Neuronal mechanosensory signaling and ionic homeostasis","description":"The top GO terms point to regulation of synaptic activity, sodium transport/homeostasis, pH response, and mechanosensory/pain detection in a neuronal context, indicating a cluster centered on neural signaling with ion/pH balance and touch/temperature sensing.","confidence":"High","size":15,"edges":96,"triangles":357,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0060025","count":7},{"id":"GO:0055078","count":7},{"id":"GO:0010447","count":7},{"id":"GO:0035725","count":7},{"id":"GO:0050891","count":7}]},{"hash":"1189203857250728751","title":"Unknown","description":"The terms span pheromone detection, mitochondrial energy metabolism, transferrin transport, iron homeostasis, endocytosis, plant development, and protein modification, with several terms marked obsolete. The set shows no clear shared function or interaction pattern among the proteins, and there are no network edges to tie them together. Therefore, I cannot assign a concise, representative function label beyond Unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0042775","count":1},{"id":"GO:0070584","count":1},{"id":"GO:0033572","count":1},{"id":"GO:0006879","count":1}]},{"hash":"698776218121721463","title":"RNA Processing and Translation","description":"The cluster is dominated by terms tied to RNA processing and protein synthesis\u2014cytoplasmic translation, translational elongation, RNA splicing, and mRNA polyadenylation\u2014suggesting a core theme around RNA maturation and translation. Additional terms (endosome sorting, abscission, viral processes) point to broader cellular trafficking or virus-related interactions but do not outweigh the central RNA/translation signal.","confidence":"Medium","size":14,"edges":60,"triangles":137,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0006414","count":2},{"id":"GO:0008380","count":2},{"id":"GO:0009838","count":2}]},{"hash":"770876129616547192","title":"Oxidative metabolism and detoxification","description":"The cluster centers on redox-related processes and detoxification, with GO terms for oxidation-reduction, cellular oxidant detoxification, xenobiotic response, and central metabolism (TCA cycle, 2-oxoglutarate metabolism). Although a few obsolete terms appear, the dominant theme ties redox balance to metabolic processing and xenobiotic handling, suggesting a cohesive functional group in oxidative metabolism and detox pathways.","confidence":"High","size":14,"edges":62,"triangles":113,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0098869","count":5},{"id":"GO:0007568","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0007369","count":3}]},{"hash":"1820995919282183415","title":"Mitotic Cell Cycle and Ubiquitination","description":"The top GO terms are strongly centered on mitosis and the mitotic cell cycle (cell division, metaphase/anaphase transition), with a notable connection to ubiquitin-mediated regulation (K11-linked ubiquitination). There is some additional signal from snoRNP assembly, but the dominant theme is mitotic progression and its ubiquitin-dependent control, making this label representative for the cluster.","confidence":"High","size":14,"edges":81,"triangles":270,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0000492","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0070979","count":8},{"id":"GO:0007091","count":8}]},{"hash":"1049433272163400979","title":"Telomere heterochromatin maintenance and replication licensing","description":"The cluster is dominated by terms about heterochromatin formation at telomeres/subtelomeres and chromatin regulation, together with MCM complex assembly and replication fork protection, pointing to chromatin state maintenance linked to DNA replication licensing. Some reproduction-related terms appear but do not define the main theme. ","confidence":"High","size":14,"edges":86,"triangles":309,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006348","count":9},{"id":"GO:0048478","count":7},{"id":"GO:0007292","count":6},{"id":"GO:0007307","count":6},{"id":"GO:0072689","count":6}]},{"hash":"1812829449489268833","title":"Neural development and amphetamine response","description":"This cluster is dominated by nervous system\u2013related terms: nervous system development, striatum development, locomotory behavior, and specifically response to amphetamine, pointing to neural circuit function and drug response. The nucleotide salvage terms appear more as general metabolic signals or annotations not central to the main theme, so the label focuses on neural development and drug responsiveness.","confidence":"Medium","size":14,"edges":17,"triangles":4,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":3},{"id":"GO:0031505","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0046677","count":3}]},{"hash":"2168274273410571490","title":"Embryonic Development and Organ Morphogenesis","description":"The top GO terms cluster around developmental processes across multiple organs\u2014left/right patterning, pancreas development, cartilage and lens morphogenesis, placental/embryonic tissue development, and EMT in heart formation\u2014with TORC1 signaling as a growth/differentiation regulator. This points to a cohesive theme of embryonic development and organ morphogenesis.","confidence":"High","size":14,"edges":70,"triangles":175,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0038202","count":2},{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2}]},{"hash":"756461137181772804","title":"Ribosome biogenesis and rRNA processing","description":"The terms are dominated by ribosome biogenesis (including LSU biogenesis/export) and LSU rRNA maturation, indicating a nucleolar ribosome-assembly module; additional terms like cell division or ER-Golgi transport may reflect linked processes or annotation noise, while some outliers (actin regulation, synaptic plasticity) could be incidental.","confidence":"High","size":14,"edges":77,"triangles":221,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":7},{"id":"GO:0000055","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0000463","count":3}]},{"hash":"526530664013646423","title":"Mitotic cell-cycle control and chromatin regulation","description":"Based on the GO terms, this cluster centers on mitosis and cell division (mitotic cell cycle, cell division, anaphase-promoting complex\u2013dependent catabolic process) and ubiquitin signaling (K11-linked ubiquitination), complemented by transcriptional and chromatin regulation (DNA-templated transcription, histone H3-K79 methylation). Together, these terms point to a cohesive theme of coordinating cell-cycle progression with transcriptional control and chromatin state.","confidence":"Medium","size":14,"edges":19,"triangles":3,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0070979","count":2},{"id":"GO:2001162","count":2}]},{"hash":"1674695576884705985","title":"Translation and RNA Processing","description":"The top GO terms cluster around core translation activities (cytoplasmic and mitochondrial translation, translational termination) with supporting RNA-processing terms (spliceosomal assembly, RNAi regulation), indicating a group centered on protein synthesis and RNA metabolism rather than a single pathway.","confidence":"High","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":9},{"id":"GO:0006415","count":4},{"id":"GO:0032543","count":3},{"id":"GO:1903833","count":3},{"id":"GO:0002181","count":3}]},{"hash":"1066250832707606390","title":"Golgi-to-endosome/lysosome trafficking","description":"The cluster is enriched for terms tied to Golgi localization, ER exit regulation, Golgi ribbon formation, and transport between Golgi, endosomes, and lysosomes, indicating a cohesive role in vesicle trafficking and protein sorting within the secretory pathway. A neuronal differentiation term appears less central to the core function.","confidence":"High","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0021707","count":3},{"id":"GO:0071955","count":3},{"id":"GO:0034499","count":3},{"id":"GO:0090630","count":2},{"id":"GO:0032486","count":2}]},{"hash":"1474584851960328082","title":"Cell cycle and ribosome biogenesis","description":"The set of terms includes DNA replication, cell division, and cell cycle alongside ribosome biogenesis, cytoplasmic translation, and regulation of translational initiation, with additional RNA processing (SSU-rRNA maturation) and stress granule localization. This suggests a coordinated role in cell growth and division, where genome duplication is linked with ribosome assembly and translation control.","confidence":"Medium","size":14,"edges":71,"triangles":181,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0006268","count":2},{"id":"GO:0006269","count":2},{"id":"GO:0007049","count":2}]},{"hash":"235835322520089570","title":"Neuronal Microtubule Dynamics and Vesicle Transport","description":"The cluster centers on microtubule biology and vesicle trafficking in neurons, evidenced by plus-end-directed vesicle transport along microtubules, retrograde synaptic vesicle transport, tubulin folding pathways, and regulation of microtubule polymerization. A few terms (antibiotic response, methionine salvage, threonine biosynthesis) are less related and likely incidental. This combination best captures cytoskeletal dynamics and neuronal transport functions.","confidence":"Medium","size":14,"edges":28,"triangles":22,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":4},{"id":"GO:0019509","count":3},{"id":"GO:0009088","count":3},{"id":"GO:0019284","count":3},{"id":"GO:0016310","count":3}]},{"hash":"309963166749509260","title":"Plant Protein and Purine Catabolism","description":"This cluster is dominated by GO terms for proteolysis and protein/peptide catabolic processes, especially in the vacuole, along with purine and ureide (allantoin) catabolism, and allantoin assimilation\u2014highlighting plant-specific nitrogen and nucleotide breakdown pathways. A non-core term about inflorescence meristem growth suggests a plant context, but the core theme centers on protein turnover and purine-derived metabolite catabolism in plants.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":3},{"id":"GO:0009442","count":2},{"id":"GO:0007039","count":2},{"id":"GO:0006760","count":2},{"id":"GO:0043171","count":2}]},{"hash":"2133886369613538774","title":"Neural sensing and learning signaling","description":"The top GO terms cluster around nervous system function: sensory perception of pain, olfactory learning, and neural signaling via regulation of GTPases, with development as a broad support term. While hypoxia and xenobiotic responses are present as general stress annotations, the explicit neural/sensory terms suggest a cohesive theme of neural sensing and signaling, even if some annotations are broader. ","confidence":"Medium","size":14,"edges":26,"triangles":12,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0043547","count":3}]},{"hash":"964960550562644122","title":"Neuroendocrine Development Signaling","description":"The top GO terms cluster around development and signaling in neural and endocrine tissues, including forebrain development, pituitary gland development, and retinoic acid receptor signaling, with additional signaling responses like response to cAMP and regulation of endothelial proliferation in developmental contexts. A few metabolic terms are present but appear peripheral to the main theme. This supports labeling the cluster as a neuroendocrine development signaling module.","confidence":"High","size":14,"edges":88,"triangles":331,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0051591","count":8},{"id":"GO:0001936","count":7},{"id":"GO:0019544","count":7},{"id":"GO:0048384","count":7},{"id":"GO:0009258","count":7}]},{"hash":"183889816115804335","title":"Nuclear RNA processing and decay","description":"The cluster shows enrichment for nuclear RNA catabolic and processing processes (antisense transcript catabolic, CUT and snoRNA catabolic processes) and related nuclear RNA metabolism activities, which suggests a shared role in RNA surveillance and processing in the nucleus. Some terms like brain development and vitamin D receptor signaling are less directly tied and may reflect pleiotropic protein functions.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070562","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0016525","count":2},{"id":"GO:1903833","count":2},{"id":"GO:0098530","count":1}]},{"hash":"2091407573871623780","title":"Inflammatory signaling and fibroblast migration","description":"This cluster\u2019s top terms cluster around signaling pathways that govern inflammation and cell movement, notably lipopolysaccharide-mediated signaling (LPS response), PI3K/AKT pathway signaling, and positive regulation of fibroblast migration. There are also notes of NF-kappaB-related activity and phosphorylation events, plus some broader developmental terms that may reflect tissue-wide signaling programs. Overall, the group seems to represent proteins involved in inflammatory signaling and cell motility rather than a single, narrow function.","confidence":"Medium","size":14,"edges":89,"triangles":341,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010763","count":10},{"id":"GO:0051092","count":10},{"id":"GO:0000186","count":9},{"id":"GO:0071479","count":9},{"id":"GO:0008584","count":9}]},{"hash":"684995465357091323","title":"Nervous system development and ECM-integrin signaling","description":"The top GO terms indicate neural development processes (axon fasciculation, axon guidance, CNS formation) coupled with extracellular matrix remodeling and integrin-mediated signaling (collagen fibril organization, cell-matrix adhesion, integrin signaling), pointing to a cohesive module coordinating neural wiring with ECM interactions. Some bone-related terms reflect broader roles of ECM in development, but the core theme remains neural patterning and adhesion signaling.","confidence":"High","size":14,"edges":80,"triangles":254,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0097155","count":5},{"id":"GO:0030199","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0001501","count":4}]},{"hash":"2001396727001050886","title":"Cartilage formation and collagen fibril organization","description":"This cluster is dominated by GO terms tied to cartilage condensation, multicellular organism development, and collagen fibril organization, with a key emphasis on prolyl hydroxylation of collagen (an oxygen-dependent modification). The presence of intracellular oxygen homeostasis underscores the oxygen requirement for proper collagen maturation, linking the developmental phase of cartilage formation to extracellular matrix assembly. While a couple of terms are broader or less directly linked (e.g., responses to fungal origin, arachidonate secretion), the core signal points to cartilage development and collagen-based ECM construction. ","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0032364","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0032504","count":2}]},{"hash":"2132997346069496040","title":"Wnt signaling and lipid modification","description":"The cluster is dominated by GO terms for the Wnt signaling pathway and its regulation, plus a specific term for depalmitoleylation, a lipid modification relevant to Wnt ligand processing. The presence of related developmental terms (lung development, neural tube patterning) supports a cohesive theme of Wnt-mediated developmental processes regulated by lipid modification. Overall, the data point to a coherent Wnt/lipid-modification functional group.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030324","count":2},{"id":"GO:0071555","count":1},{"id":"GO:0006507","count":1},{"id":"GO:0016055","count":1},{"id":"GO:0090090","count":1}]},{"hash":"420579577044147941","title":"Calcium signaling in neural and cardiac development","description":"This cluster is enriched for calcium transport terms (calcium ion transport, calcium ion transmembrane transport), neural plasticity (long-term potentiation), and developmental processes in neural and cardiac tissues (heart development, retina layer formation, connective tissue remodeling), with supporting signaling regulation and cytoskeletal transport terms. Together these terms point to a cohesive theme of calcium-dependent signaling coordinating development and synaptic function.","confidence":"High","size":14,"edges":58,"triangles":135,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006470","count":14},{"id":"GO:0007507","count":13},{"id":"GO:0060291","count":13},{"id":"GO:0043547","count":13},{"id":"GO:0070588","count":12}]},{"hash":"1572093960205090240","title":"Actin Cytoskeleton Remodeling and Protrusion Assembly","description":"This cluster is enriched for terms governing actin cytoskeleton organization and the assembly of lamellipodia and filopodia, including positive regulation of their formation and related actin filament-based movement. The presence of axon regeneration and collateral sprouting terms further suggests roles in neurite outgrowth and remodeling. Taken together, the proteins likely participate in actin-driven cytoskeletal remodeling and membrane protrusion.","confidence":"High","size":14,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":2},{"id":"GO:0048680","count":2},{"id":"GO:0010592","count":1},{"id":"GO:0051497","count":1},{"id":"GO:0048669","count":1}]},{"hash":"80382009209331877","title":"Insect eye and antennal development","description":"Top terms are dominated by antennal development, photoreceptor/eye morphogenesis, and sensory perception, with supporting terms about actin dynamics and tissue morphogenesis. This points to a theme of sensory organ development in insects, especially the eye and antenna. Therefore a concise label is 'Insect eye and antennal development'.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":3},{"id":"GO:0007469","count":2},{"id":"GO:0045316","count":2},{"id":"GO:0002182","count":2},{"id":"GO:0042594","count":2}]},{"hash":"1757144605111559858","title":"Immune Response and Antigen Presentation","description":"The cluster shows strong enrichment for immune-related functions: regulation of antibacterial peptide production, systemic acquired resistance, and antigen processing and presentation via MHC class II, suggesting a core theme of innate and adaptive immune defense. Other terms like renin-angiotensin regulation and digestion appear as peripheral contexts, but do not negate the central immune signal. Confidence: Medium","confidence":"","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002016","count":2},{"id":"GO:0002803","count":2},{"id":"GO:0001823","count":2},{"id":"GO:0002018","count":2},{"id":"GO:0009627","count":2}]},{"hash":"841053317204356658","title":"Vascular immune remodeling and proteolysis","description":"This cluster is enriched for proteolysis, complement activation (classical and lectin), angiogenesis, leukocyte rolling, and fibrinolysis, all of which point to coordinated vascular remodeling with immune and proteolytic regulation. The ANP-regulated blood pressure term and development terms are related but less central, so the core theme is extracellular proteolysis linked to vascular-immune processes.","confidence":"Medium","size":14,"edges":22,"triangles":30,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":7},{"id":"GO:0045766","count":6},{"id":"GO:0006958","count":6},{"id":"GO:0001867","count":6},{"id":"GO:0003050","count":6}]},{"hash":"1913174234843372868","title":"Heart and neural-sensory tissue development","description":"The cluster is dominated by terms for heart development, retina formation, and visual perception, with supporting terms for neural transport, calcium signaling, and muscle cell fate. Together these indicate a theme of development and differentiation across cardiac, sensory, and neural tissues, with related cytoskeletal and transport processes. A few terms are less connected (e.g., polysaccharide catabolism), but the core signal is multicellular tissue development centered on heart and sensory/neural systems.","confidence":"Medium","size":14,"edges":58,"triangles":121,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":12},{"id":"GO:0022011","count":11},{"id":"GO:0007601","count":11},{"id":"GO:0019749","count":10},{"id":"GO:0010842","count":10}]},{"hash":"1704195484164590384","title":"Mechanotransduction and cytoskeletal signaling","description":"The cluster is dominated by terms related to mechanical stimuli and cytoskeletal dynamics, such as cellular response to mechanical stimulus, response to muscle stretch, Rho signaling, and actin cytoskeleton reorganization, plus ERK cascade regulation. While some terms like nervous system development and fat cell differentiation are more peripheral, the core signals point to mechanosensing and cytoskeletal signaling pathways.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":4},{"id":"GO:0043552","count":4},{"id":"GO:0045444","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0007266","count":3}]},{"hash":"602589918928157503","title":"Unknown","description":"The top GO terms are very heterogeneous, covering development, sensory perception, ion transport, drug response, GTPase signaling, transcription regulation, lipid catabolism, cell cycle control, cGMP signaling, and immune regulation. There isn't a single unifying function across these proteins, so there is no clear theme to name; therefore Unknown with None confidence.","confidence":"","size":14,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0097338","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0007264","count":1}]},{"hash":"587527314930446913","title":"Cardiac conduction and development","description":"These proteins show strong enrichment for cardiac electrophysiology terms (AV node action potential, regulation of heart rate by cardiac conduction, atrial depolarization, ventricular repolarization) with supporting development signals (BMP signaling, ossification). Immune terms are present but secondary. Thus, the cluster most plausibly reflects proteins involved in heart electrical activity and heart development.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0043931","count":3},{"id":"GO:0006828","count":2},{"id":"GO:0086016","count":2},{"id":"GO:0086091","count":2}]},{"hash":"2134662029500647162","title":"Developmental signaling and organogenesis","description":"This cluster is enriched for terms tied to development across multiple tissues (bone ossification, multicellular organism development, nervous system development) and organogenesis aspects such as SA node cell action potential regulation, suggesting a shared theme of developmental signaling guiding organ formation and function. Additional entries in signaling pathways (ERK cascade, ubiquitination) and mechanosensing support a broader developmental signaling context rather than a single tissue-specific process.","confidence":"Medium","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0007399","count":5},{"id":"GO:0098907","count":5},{"id":"GO:0045087","count":5}]},{"hash":"2000061861737622773","title":"Mechanosensation and Ion Homeostasis","description":"Top GO terms converge on mechanosensation (detection and regulation of mechanical stimuli, mechanosensory behavior) and ion/pH homeostasis (sodium transport, sodium ion homeostasis, pH response). This suggests a cohesive theme of sensing mechanical cues while maintaining ionic and pH balance, across the protein set.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060025","count":2},{"id":"GO:0055078","count":2},{"id":"GO:0010447","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0050891","count":2}]},{"hash":"148860166850144808","title":"Chitin-based cell wall biogenesis and spore formation","description":"The top GO terms point to chitin-containing structures (larval cuticle, spore wall) and related assembly processes, along with biofilm formation and carbohydrate metabolism, suggesting a cohesive theme of cell wall biogenesis and sporulation in microbes/fungi. Some terms like antibiotic response and inflammatory mediator production may reflect stress or host-interaction contexts commonly associated with biofilms or pathogenic niches. ","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":10},{"id":"GO:0034232","count":2},{"id":"GO:0042710","count":2},{"id":"GO:0009245","count":2},{"id":"GO:0019428","count":2}]},{"hash":"2161852157438723278","title":"Neural synapse formation and signaling","description":"The terms mostly describe neural development and synaptic function\u2014glutamatergic and GABA signaling, receptor clustering and recycling, and cerebellar granule cell differentiation, along with pons maturation. A few outliers exist (lateral line development, osteoclast proliferation), but they don\u2019t shift the overall theme toward non-neural processes. Thus the label reflects the core function of the cluster.","confidence":"High","size":14,"edges":35,"triangles":63,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0048899","count":1},{"id":"GO:0035249","count":1},{"id":"GO:0097011","count":1},{"id":"GO:0002158","count":1},{"id":"GO:0007214","count":1}]},{"hash":"853765841397475126","title":"Olfactory and pheromone chemosensation","description":"The top GO terms point to smells and pheromones: sensory perception of smell, olfactory behavior, detection of chemical stimuli involved in smell, and detection of pheromones, plus courtship behavior. This indicates a chemosensory module focused on olfactory cues and pheromone signaling; extra terms like CO2 detection or responses to certain chemicals suggest broader chemical sensing but do not override the olfactory/pheromonal theme.","confidence":"High","size":14,"edges":62,"triangles":123,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":6},{"id":"GO:0042048","count":6},{"id":"GO:0050911","count":6},{"id":"GO:0043695","count":6},{"id":"GO:0007608","count":6}]},{"hash":"407042367616993649","title":"Mitochondrial energy metabolism and neuroimmune signaling","description":"The top GO terms center on mitochondrial pyruvate import and acetyl-CoA biosynthesis, pointing to energy production and ATP metabolism, with insulin secretion in response to glucose indicating a link between metabolism and endocrine signaling. Additional terms touch on glial regulation, TNF/LPS responses, and pain/hormonal signaling, suggesting a broader neuroimmune/stress-related context anchored by mitochondrial metabolism. Confidence in this thematic link is Moderate to High, but the presence of several peripheral terms makes it a cautious Medium. ","confidence":"Medium","size":14,"edges":56,"triangles":105,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1902361","count":2},{"id":"GO:0035774","count":2},{"id":"GO:0061732","count":2},{"id":"GO:0060253","count":1},{"id":"GO:0008347","count":1}]},{"hash":"1427689565664183666","title":"Unknown","description":"These GO terms are scattered across detoxification, vesicle trafficking, differentiation, inflammation, signaling, and metabolism, with no clear shared process dominating, so a cohesive functional label cannot be anchored.","confidence":"","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0033327","count":1},{"id":"GO:0014070","count":1},{"id":"GO:0034097","count":1}]},{"hash":"865860400636389834","title":"Unknown","description":"The top terms cover endocrine/secretory processes (gastric acid secretion), developmental biology (kidney glomerulus), immune function (IgA isotype switching, eosinophil chemotaxis), circadian regulation, GPCR- and ERK signaling, platelet activation, and even a behavioral concept (operant conditioning). This spread across diverse tissues and pathways suggests no single cohesive function tying all proteins together, so a specific label cannot be reliably assigned. ","confidence":"","size":14,"edges":62,"triangles":132,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001698","count":13},{"id":"GO:0072224","count":13},{"id":"GO:0048290","count":13},{"id":"GO:0042752","count":13},{"id":"GO:0071880","count":13}]},{"hash":"608295661091198286","title":"Developmental Transcriptional Regulation","description":"This cluster centers on terms about positive regulation of transcription by RNA polymerase II and several developmental processes (pancreas, midbrain, post-embryonic development), pointing to a theme of gene-expression control during development. While a few terms touch on immune or signaling aspects, the dominant signal is regulatory transcription linked to developmental contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":14},{"id":"GO:0031017","count":14},{"id":"GO:1903238","count":14},{"id":"GO:0051919","count":14},{"id":"GO:0030901","count":14}]},{"hash":"2066449921876033433","title":"Axon guidance and synapse assembly","description":"This cluster\u2019s GO terms cluster around neuronal connectivity: axon guidance (including midline recognition), dendrite guidance, and synapse assembly. Although there are also terms related to receptor internalization and cilium assembly, the dominant theme is neural wiring and synaptic organization, which supports a coherent label for the set of proteins. Edges are absent in the current network, but the functional annotation aligns with neuronal development and synaptic formation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":1},{"id":"GO:0070983","count":1},{"id":"GO:0002092","count":1},{"id":"GO:0035071","count":1},{"id":"GO:0016199","count":1}]},{"hash":"827452300241619080","title":"Gene expression regulation: transcription, translation, chromatin","description":"The cluster combines terms for transcriptional control (RNA Pol I repression), chromatin/heterochromatin dynamics, translation processes (elongation and fidelity), and a signaling influence (TGF-beta pathway), suggesting proteins that coordinate gene expression from transcription through translation, with possible links to chromatin state and stress responses. Some terms are obsolete, reflecting historical annotations but not changing the overall theme.","confidence":"Medium","size":13,"edges":34,"triangles":43,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0071479","count":2},{"id":"GO:0006414","count":2},{"id":"GO:0032232","count":2},{"id":"GO:1990145","count":2},{"id":"GO:0030511","count":2}]},{"hash":"2158529040086695736","title":"RNA splicing regulation and translation initiation","description":"The top GO terms center on regulation of mRNA splicing via the spliceosome, along with supporting RNA processing activities (small-subunit processome assembly, mRNA stabilization, polyadenylation regulation) and assembly of the eukaryotic translation initiation factor 4F complex. This combination points to a cluster of proteins involved in post-transcriptional RNA processing and the initiation of translation, rather than transcriptional control or other pathways.","confidence":"High","size":13,"edges":67,"triangles":194,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048025","count":4},{"id":"GO:0048255","count":3},{"id":"GO:0034462","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0000381","count":3}]},{"hash":"1798714847356728366","title":"Developmental differentiation and protein homeostasis","description":"Terms repeatedly point to developmental processes across tissues (forebrain, lens, male gonads) and general multicellular development, with supporting signals of protein regulation via ubiquitination and ERAD and GTPase signaling, suggesting a cluster centered on development coupled with protein homeostasis.","confidence":"High","size":13,"edges":10,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0007275","count":2}]},{"hash":"549320343872364646","title":"Chromatin regulation and transcription control","description":"Elements point to nuclear regulation of gene expression: several GO terms center on DNA-templated transcription, negative regulation of transcription (miRNA), and chromatin-related processes (rDNA heterochromatin formation, histone H4 deacetylation). Additional terms imply proteostasis involvement (ubiquitination regulation, chaperone-mediated assembly) and impacts on muscle differentiation and hormone signaling. Taken together, this cluster likely comprises chromatin remodeling and transcription-control proteins with roles in muscle biology and stress response.","confidence":"High","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":7},{"id":"GO:1902894","count":4},{"id":"GO:0031397","count":4},{"id":"GO:0090035","count":3},{"id":"GO:0048742","count":3}]},{"hash":"232911452498939285","title":"Actin-based vesicle trafficking and muscle remodeling","description":"The cluster\u2019s GO terms concentrate on the actin cytoskeleton (actin filament bundle distribution), vesicle docking/secretory granule localization, and muscle-related processes (cardiac/skeletal muscle development and contraction), plus microvillus organization. This suggests a core theme of cytoskeleton-driven vesicle trafficking and structural support in muscle and epithelial contexts, with a few peripheral terms. ","confidence":"Medium","size":13,"edges":43,"triangles":64,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006904","count":3},{"id":"GO:0048739","count":3},{"id":"GO:0038096","count":3},{"id":"GO:0003009","count":3}]},{"hash":"918631286815945079","title":"Neuronal synapse organization and spine morphogenesis","description":"The cluster shows strong enrichment for synaptic terms: synapse organization, positive regulation of excitatory postsynaptic potential, protein localization to synapse, receptor clustering, and dendritic spine morphogenesis, along with Rho signaling linked to cytoskeletal remodeling. Cholesterol biosynthesis also supports membrane integrity for synapses, suggesting a cohesive module governing synapse assembly, maintenance, and spine maturation in neurons.","confidence":"High","size":13,"edges":25,"triangles":25,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008285","count":12},{"id":"GO:0006695","count":11},{"id":"GO:2000463","count":7},{"id":"GO:0050808","count":7},{"id":"GO:0032298","count":6}]},{"hash":"1337335168266266983","title":"Ribosome biogenesis and snRNP assembly","description":"The cluster is dominated by GO terms related to maturation of rRNA (5.8S and LSU), assembly and export of the ribosomal large subunit, and spliceosomal snRNP assembly, indicating a coherent theme of ribosome and snRNP biogenesis. A couple of endocrine-related terms appear but are not the main signal. ","confidence":"High","size":13,"edges":45,"triangles":96,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0000387","count":2},{"id":"GO:0000027","count":1},{"id":"GO:1902626","count":1}]},{"hash":"723318375137139525","title":"ER-Golgi Trafficking and Wnt Secretion","description":"The top GO terms point to core secretory pathway processes: ER-to-Golgi vesicle transport, COPI coating, Golgi ribbon formation, and regulation of ER exit, indicating machinery for protein trafficking. In addition, positive regulation of Wnt protein secretion and related axis specification terms suggest involvement in signaling that relies on proper secretion. Although some developmental terms reference organism-specific phenotypes, they align with secretory-regulated signaling roles, justifying a label focused on ER-Golgi trafficking and Wnt secretion. ","confidence":"High","size":13,"edges":51,"triangles":126,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0090161","count":6},{"id":"GO:0006621","count":4},{"id":"GO:0048042","count":4},{"id":"GO:0007311","count":4}]},{"hash":"52505528104558352","title":"Inflammation and stress signaling","description":"This cluster is centered on inflammatory and stress-responsive signaling: terms for cellular responses to LPS and TNF, positive regulation of the p38MAPK cascade, and modulation of NF-\u03baB activity, all pointing to immune/inflammatory signal transduction. Additional terms related to ionomycin signaling, nuclear import regulation, and regulatory layers in RNA processing and ubiquitination suggest broader regulatory context that accompanies these signaling pathways. Overall, the dominant theme is inflammatory and stress-activated signaling.","confidence":"Medium","size":13,"edges":13,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:1904637","count":1},{"id":"GO:0042307","count":1},{"id":"GO:1900745","count":1},{"id":"GO:0010884","count":1},{"id":"GO:0032088","count":1}]},{"hash":"2184808052653014205","title":"Cell stress signaling and actin remodeling","description":"The cluster is enriched for stress-related processes (cellular response to hypoxia, positive regulation of apoptosis, autophagy, and proteasomal degradation) and cytoskeletal dynamics (barbed-end actin filament uncapping and related capping regulation), along with signaling pathways (NF-\u03baB and NOD2) and neuronal remodeling cues (axonogenesis, mechanical stimulus response). This suggests a coherent theme of cellular stress signaling coupled with cytoskeletal regulation.","confidence":"High","size":13,"edges":38,"triangles":41,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071456","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0043065","count":2},{"id":"GO:0016239","count":2},{"id":"GO:0031146","count":2}]},{"hash":"354812330135114725","title":"Unknown","description":"The top terms span plant hormone signaling, animal glucocorticoid signaling, drug response, and heavy metal response, with only one edge and several obsolete terms, indicating no single cohesive function for the cluster.","confidence":"","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051348","count":1},{"id":"GO:1903071","count":1},{"id":"GO:0009736","count":1},{"id":"GO:0031400","count":1},{"id":"GO:0051291","count":1}]},{"hash":"197474701843759748","title":"Neural synapse development and social behavior","description":"The cluster is dominated by terms related to synapse assembly, organization, and chemical transmission, including positive regulation of synapse assembly and regulation of excitatory postsynaptic potential, pointing to neural connectivity and function. In addition, behavioral terms such as vocalization, social behavior, and regulation of grooming suggest involvement of neural circuits governing communication and social interactions. An outlier term for heart development may reflect pleiotropic gene roles or annotation overlap, but the core signal centers on synaptic development and function linked to behavior.","confidence":"High","size":13,"edges":46,"triangles":67,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":5},{"id":"GO:0071625","count":4},{"id":"GO:2000463","count":3},{"id":"GO:0007268","count":3},{"id":"GO:0007507","count":3}]},{"hash":"1913163884796522514","title":"Neuronal synaptic signaling and development","description":"This cluster is enriched for terms related to glutamatergic and GABAergic synaptic transmission, regulation of synaptic activity, and brain development (pon maturation, anterior lateral line development) as well as receptor recycling, pointing to proteins involved in neural signaling and development. A few non-neural terms (fungicide/ethanol response, GM-CSF stimulus, osteoclast proliferation) appear but are less representative of the core function.","confidence":"Medium","size":13,"edges":32,"triangles":48,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":8},{"id":"GO:0045471","count":8},{"id":"GO:0048899","count":7},{"id":"GO:0035249","count":7},{"id":"GO:0097011","count":7}]},{"hash":"1624722310440548202","title":"Nucleotide salvage and quinone biosynthesis","description":"The cluster shows enrichment for nucleotide salvage terms (uracil salvage, guanine salvage, IMP salvage) and quinone biosynthesis terms (menaquinone and phylloquinone biosynthesis), which together point to bacterial metabolism centered on nucleotide reuse and electron-transport cofactors. Additional catabolic and antibiotic biosynthesis terms exist, but the common thread appears to be salvage pathways and quinone biosynthesis; one term (striatum development) seems unrelated noise.","confidence":"Medium","size":13,"edges":42,"triangles":56,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006223","count":4},{"id":"GO:0009234","count":4},{"id":"GO:0006635","count":4},{"id":"GO:0042372","count":4},{"id":"GO:0006574","count":4}]},{"hash":"1488377302648157397","title":"Unknown","description":"The top GO terms are highly heterogeneous, spanning neural development (neural tube initiation, neuron maturation), reproductive development (oocyte maturation), innate immune signaling, and general cellular processes (ubiquitin-proteasome degradation, endosome-Golgi transport), with several obsolete annotations. This mix provides no clear, single function characterizing the cluster, so a cohesive label cannot be assigned beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021993","count":3},{"id":"GO:0001556","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0014041","count":3},{"id":"GO:0002755","count":3}]},{"hash":"2092635021053835793","title":"Mitochondrial Respiratory Chain and ATP Synthesis","description":"The cluster is dominated by GO terms tied to mitochondrial energy metabolism\u2014aerobic respiration, ETC steps from ubiquinol to cytochrome c and from cytochrome c to oxygen, proton transmembrane transport, and proton-motive-force\u2013driven ATP synthesis, plus Complex IV assembly. This cohesive set points to oxidative phosphorylation and mitochondrial respiration as the core function of the proteins, with some peripheral terms appearing as noise. ","confidence":"High","size":13,"edges":73,"triangles":238,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":2},{"id":"GO:0006122","count":2},{"id":"GO:1902600","count":2},{"id":"GO:0033674","count":1},{"id":"GO:0007286","count":1}]},{"hash":"1789523543618130906","title":"ER-Golgi Trafficking and ER Proteostasis","description":"The proteins cluster around secretory pathway and quality-control functions: receptor-mediated endocytosis, ER-to-Golgi vesicle transport, GPI anchor biosynthesis, and ER-associated protein degradation with proteasomal processing. The convergence of these GO terms suggests a cohesive role in handling secreted and membrane proteins via the ER-Golgi network and in maintaining proteostasis, despite some older/obsolete annotations and a few more general processes like cell division or chemotaxis appearing less related. ","confidence":"High","size":13,"edges":48,"triangles":82,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006898","count":3},{"id":"GO:0006490","count":3},{"id":"GO:0006888","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1930901832523305057","title":"Organogenesis signaling in kidney, bone, and lymphatics","description":"These terms cluster around developmental processes in multiple organs (metanephric glomerulus development, bone development, lymph vessel morphogenesis) and involve key signaling pathways (cell surface receptor tyrosine kinase signaling, Toll-like receptor signaling) along with responses to immune stimuli and mechanical cues. The mix suggests a broad developmental signaling program spanning organogenesis and attendant immune sensing rather than a single specific pathway. ","confidence":"Medium","size":13,"edges":52,"triangles":92,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0072224","count":9},{"id":"GO:0090260","count":9},{"id":"GO:0007169","count":9},{"id":"GO:0071222","count":9},{"id":"GO:0002091","count":9}]},{"hash":"1453490178780898573","title":"Mitochondrial stress response and immune signaling","description":"This cluster shows strong signals for mitochondrial processes (cardiolipin metabolism, stress-induced fusion, and morphogenesis) alongside immune-related activities (IL-2 production, T cell polarity). The combination suggests a theme of mitochondria-driven stress responses that interface with immune signaling, with dopaminergic transmission as a broader signaling context.","confidence":"Medium","size":13,"edges":34,"triangles":29,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":3},{"id":"GO:0001302","count":3},{"id":"GO:1900210","count":3},{"id":"GO:1903905","count":3},{"id":"GO:0045541","count":3}]},{"hash":"199032134329458720","title":"Diverse Catabolic Metabolism","description":"The terms show multiple substrate-specific catabolic processes (uracil, 1,2-dichloroethane, glucuronoside, alkaloids) and related detox/response terms, with some metabolism-related processes like polyhydroxybutyrate biosynthesis, suggesting a cluster enriched for catabolic/metabolic activities across various compounds rather than a single signaling pathway. A few terms are regulatory or obsolete, but the core theme centers on metabolism and detoxification.","confidence":"Medium","size":13,"edges":23,"triangles":15,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0097755","count":5},{"id":"GO:2000124","count":5},{"id":"GO:0019260","count":5},{"id":"GO:0042619","count":5},{"id":"GO:0019391","count":5}]},{"hash":"1447685782788886206","title":"Transcription-driven multi-tissue development","description":"This cluster is dominated by GO terms for transcription by RNA polymerase II and a suite of tissue- and organ-specific differentiation processes (heart left ventricle formation, smooth muscle development, adrenal chromaffin cell differentiation, kidney mesenchymal differentiation, sex determination, and even plant anther development), suggesting a broad transcriptional program guiding diverse developmental outcomes. The mixed tissue terms imply a general developmental regulatory theme rather than a single pathway, though annotation noise (e.g., plant term) may contribute to the diversity.","confidence":"Medium","size":13,"edges":73,"triangles":235,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":9},{"id":"GO:0003218","count":8},{"id":"GO:0007540","count":8},{"id":"GO:0060948","count":8},{"id":"GO:0048658","count":8}]},{"hash":"2244551518099122786","title":"Dopamine signaling and brain development","description":"The strongest terms are adenylate cyclase-activating dopamine receptor signaling pathway and brain development, pointing to dopaminergic signaling as a core theme. Additional GPCR-related terms (heterotrimeric G-protein cycles, positive regulation of GTPase activity), along with development-related terms (gastrulation cytoskeleton polarity, skeletal system development) and transport processes (ER-Golgi vesicle trafficking), suggest a cluster of proteins engaged in signaling pathways that influence neurodevelopment and associated cellular organization. This combination indicates a coherent theme around neuronal signaling and development rather than a single focused metabolic process. ","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":12},{"id":"GO:0031684","count":12},{"id":"GO:0003380","count":12},{"id":"GO:0001501","count":11},{"id":"GO:0051301","count":11}]},{"hash":"1677910397270449262","title":"Wnt signaling and gland development","description":"Top terms suggest a theme around Wnt signaling driving development of lipid-producing glands (mammary and sebaceous) and related adipose metabolism; palmitoylation links to Wnt processing, and the presence of leptin response and triglyceride catabolism supports a metabolic context. Some entries are obsolete or less connected, but the core pattern centers on developmental signaling and gland/lipid biology.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015015","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0018230","count":2},{"id":"GO:0042144","count":2}]},{"hash":"669431051797268993","title":"Immune and Developmental Signaling","description":"The Top Terms include several signaling pathways (PI3K/AKT, insulin signaling, lipopolysaccharide signaling) alongside immune processes (IL-4 production, hemopoiesis, B cell maturation) and developmental terms (cell morphogenesis, skeletal muscle development, mitotic cell cycle), suggesting a broad signaling network coordinating immune development and tissue development rather than a single specific function.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0031663","count":3},{"id":"GO:0000902","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0007519","count":3}]},{"hash":"2195166017752675487","title":"Sperm acrosome and axoneme assembly with lipid remodeling","description":"Proteins cluster around acrosome assembly and sperm axoneme formation, core components of spermatogenesis, with supporting lipid/phospholipid metabolism and arachidonic acid pathways that facilitate membrane remodeling and signaling during fertilization. Some terms appear noisy (e.g., plant-specific biosynthesis), but the dominant theme is male gamete development and organelle assembly.","confidence":"Medium","size":13,"edges":52,"triangles":128,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0043303","count":3},{"id":"GO:0007288","count":3},{"id":"GO:0016042","count":3},{"id":"GO:0019372","count":3},{"id":"GO:0050482","count":3}]},{"hash":"970724687454578653","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033209","count":2},{"id":"GO:0034051","count":2},{"id":"GO:0042771","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0042347","count":2}]},{"hash":"1957747706253376331","title":"Xenobiotic and amino acid catabolism","description":"These proteins appear linked to diverse catabolic pathways for small organic molecules and detoxification processes, including mercury ion detoxification and breakdown of compounds like camphor, propylene, halogen, and L-isoleucine. The presence of a response to L-glutamate hints at amino-acid\u2013related signaling, but the dominant theme is metabolic catabolism and detoxification. Some terms related to histone methylation and apoptotic DNA fragmentation may reflect broader stress responses rather than core cluster function.","confidence":"Medium","size":13,"edges":11,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050787","count":3},{"id":"GO:1902065","count":3},{"id":"GO:0051573","count":2},{"id":"GO:1902510","count":2},{"id":"GO:0019383","count":2}]},{"hash":"1960633708780089080","title":"Muscle development and regeneration","description":"In this cluster the top GO terms center on muscle biology: ventricular cardiac muscle tissue morphogenesis, muscle cell fate specification, and regulation of satellite cell activation in skeletal muscle regeneration, all pointing to muscle development and regeneration. Additionally, calcium transport and ATPase-coupled calcium transporter activity are key for muscle contraction and signaling, reinforcing a muscle-centric functional theme. Some terms touch on broader tissue morphogenesis and remodeling, but the dominant signal is muscle development and calcium-dependent processes.","confidence":"High","size":13,"edges":51,"triangles":97,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055010","count":4},{"id":"GO:0033234","count":3},{"id":"GO:0019749","count":3},{"id":"GO:0010842","count":3},{"id":"GO:1905205","count":3}]},{"hash":"2216839317614139292","title":"Unknown","description":"The top terms are highly heterogeneous, spanning amino acid and kynurenine metabolism, alkaloid and methanofuran biosynthesis, Notch signaling, reproductive development (Leydig cell differentiation, luteinization), sensory/behavioral responses (thermotaxis, pyrethroid response), and neurotransmitter biosynthesis. There is no single cohesive function uniting these terms, so a meaningful, specific label cannot be assigned. ","confidence":"","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0097053","count":6},{"id":"GO:0042853","count":6},{"id":"GO:0007219","count":6},{"id":"GO:0046684","count":6},{"id":"GO:2001120","count":6}]},{"hash":"1738045516567290485","title":"Diverse metabolite and lipid transport","description":"The cluster centers on transport and export activities across membranes, including lipoprotein transport, peroxisomal fatty acid import, ceramide translocation, glycine betaine and methionine transport, cobalt ion transport, oligopeptide export from mitochondrion, peptide pheromone export, and bacteriocin transport. This suggests a cohesive theme of diverse molecule trafficking (lipids, amino acids, peptides, ions) within and between compartments, with a possible ancillary link to metal stress responses such as mercury ion exposure. Overall, it reflects a transporter-focused functional signature rather than a single specific pathway.","confidence":"High","size":13,"edges":70,"triangles":226,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":11},{"id":"GO:0015910","count":11},{"id":"GO:0046689","count":11},{"id":"GO:0043213","count":11},{"id":"GO:0031460","count":11}]},{"hash":"1108924701051622899","title":"Planar cell polarity-driven morphogenesis","description":"The proteins cluster around concepts of planar cell polarity (PCP) and tissue morphogenesis, highlighted by terms like establishment of body hair planar orientation and planar dichotomous subdivision of terminal units in lung branching morphogenesis, plus related adhesion and neural development terms. This suggests a coherent theme of PCP-guided developmental organization, with some peripheral neural signaling and vascular/immune associations likely reflecting multifunctional roles.","confidence":"Medium","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:0060489","count":2},{"id":"GO:0036514","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0007156","count":2}]},{"hash":"372183477357301467","title":"Steroid Hormone Metabolism and Signaling","description":"This cluster is dominated by GO terms tied to steroid hormone metabolism (androgen, progesterone, testosterone biosynthesis) and hormone signaling (response to thyroid hormone, retinoic acid receptor signaling). While there are a few unrelated metabolic and transport terms, the hormone-related terms provide a cohesive functional theme around hormone biology.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":13},{"id":"GO:0019568","count":13},{"id":"GO:0097066","count":13},{"id":"GO:0042448","count":13},{"id":"GO:0071805","count":13}]},{"hash":"159779810355393890","title":"Olfactory chemosensation and pheromone detection","description":"The cluster is enriched for GO terms tied to smell, olfactory behavior, pheromone detection, and courtship, indicating proteins involved in chemosensory signaling and pheromone-driven behaviors. Several terms relate to general chemical stimulus detection, but the dominant theme centers on olfactory perception and social/sexual behavioral responses.","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":4},{"id":"GO:0042048","count":4},{"id":"GO:0050911","count":4},{"id":"GO:0043695","count":4},{"id":"GO:0007608","count":4}]},{"hash":"2217931642784965793","title":"Autophagy and Cell Cycle Regulation","description":"The GO terms cluster around cell growth control and autophagy\u2014regulation of the cell cycle, negative regulation of fibroblast proliferation, tissue homeostasis, and positive/autophagic cell death\u2014suggesting a theme of coordinating cell proliferation with autophagy to maintain tissue integrity. Some chromatin-related terms appear but are less dominant. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":1},{"id":"GO:2000270","count":1},{"id":"GO:0016569","count":1},{"id":"GO:0030336","count":1},{"id":"GO:0071447","count":1}]},{"hash":"1361242744416723394","title":"Egg activation and eggshell formation","description":"The GO terms point to reproductive processes centered on egg activation (GO:0007343) and the formation of the chorion-containing eggshell (GO:0007305), suggesting the cluster's proteins are involved in early egg development and eggshell assembly. The presence of an obsolete reproduction term reinforces the reproductive context, though there are no observed interactions in this dataset. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007343","count":1},{"id":"GO:0007305","count":1},{"id":"GO:0032504","count":1}]},{"hash":"1200064537207902108","title":"Mitochondrial Transport and Energy Regulation","description":"Primarily centered on mitochondrial function: several terms describe transport of substrates and energy carriers (ADP/ATP, citrate) and iron into mitochondria, plus regulation of mitochondrial membrane potential. Additional terms reflect redox and oxidative stress responses (superoxide) within mitochondria, supporting a theme of mitochondrial energy production and redox balance. A few terms (glycine import, female pregnancy) are less directly tied but do not override the dominant mitochondrial pattern.","confidence":"High","size":13,"edges":75,"triangles":255,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":13},{"id":"GO:0007565","count":13},{"id":"GO:0036233","count":13},{"id":"GO:0048250","count":13},{"id":"GO:0051881","count":13}]},{"hash":"1937899026837761376","title":"Unknown","description":"The listed GO terms span a broad and disparate set of processes (fibroblast proliferation, spermatocyte division, osteoclast fusion, neuron migration, thymus development, smooth muscle cell migration, endocytosis, B cell proliferation, and mitochondrial regulation) with no single dominant theme or shared pathway. Because there is no clear, cohesive function tying these terms together, a specific, representative label cannot be confidently assigned beyond Unknown.","confidence":"","size":13,"edges":57,"triangles":123,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0048147","count":2},{"id":"GO:0048137","count":2},{"id":"GO:0072675","count":2},{"id":"GO:0001764","count":2},{"id":"GO:1902237","count":2}]},{"hash":"1085523888693822931","title":"Mitochondrial Energetics and ER Glycoprotein Processing","description":"The top GO terms point to mitochondrial metabolism (pyruvate import, ATP synthase assembly, mitochondrial autophagy, and acetyl-CoA biosynthesis) as well as ER/Golgi-associated protein maturation (GPI anchor biosynthesis, O-linked glycosylation via mannose, and ER tubular network organization), suggesting a theme of organelle biogenesis and energy regulation with linked protein processing. The insulin secretion term hints at metabolic relevance in glucose-stimulated cells but is less central than the organelle-centric terms.","confidence":"Medium","size":13,"edges":9,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:1902361","count":1},{"id":"GO:0035774","count":1},{"id":"GO:0061732","count":1},{"id":"GO:0035269","count":1}]},{"hash":"513111004044074636","title":"Nervous system development and synaptic signaling","description":"The top GO terms center on neural development and function, notably nervous system development, myelination, and regulation of inhibitory postsynaptic potentials, which together point to CNS differentiation and synaptic signaling. There are additional terms related to other tissues and immune processes that appear as outliers, but the strongest common theme among the cluster members is neural development and synaptic activity.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0001812","count":2},{"id":"GO:0061042","count":2},{"id":"GO:0035157","count":2},{"id":"GO:0031643","count":2}]},{"hash":"1229001760346860384","title":"Developmental transcriptional regulation","description":"The cluster centers on GO terms for developmental processes (exocrine pancreas development, midbrain development, post-embryonic development) and for transcriptional control by RNA polymerase II, suggesting a cohesive theme of gene regulation during development, with supporting signals related to cell proliferation and metabolic responsiveness.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":13},{"id":"GO:0031017","count":13},{"id":"GO:1903238","count":13},{"id":"GO:0051919","count":13},{"id":"GO:0030901","count":13}]},{"hash":"2009973926086144942","title":"Hormone and xenobiotic metabolism","description":"The Top Terms are dominated by metabolic processes for hormones (androgen, progesterone, vitamin D) and xenobiotics (camphor, coumarin, vancomycin biosynthesis). This pattern points to a cluster whose proteins participate in diverse chemical metabolism and related cellular responses, with a few immune-regulatory terms that might reflect downstream effects rather than core function.","confidence":"Medium","size":13,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":13},{"id":"GO:0019383","count":13},{"id":"GO:0010164","count":13},{"id":"GO:0035865","count":13},{"id":"GO:0046226","count":13}]},{"hash":"367313908408678133","title":"Neuronal mechanosensation and ion homeostasis","description":"The top GO terms cluster around sensory detection of mechanical stimuli and pain, mechanosensory behavior, and regulation of synaptic activity, complemented by sodium ion homeostasis and transmembrane transport as well as pH responses. This pattern points to neural signaling that links mechanosensory perception with ion-channel\u2013mediated homeostasis, suggesting a functional group focused on neuronal sensory transduction and ionic regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060025","count":4},{"id":"GO:0055078","count":4},{"id":"GO:0010447","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0050891","count":4}]},{"hash":"346932358102124386","title":"Mitochondrial transport and metabolic signaling","description":"The top GO terms cluster around transport across mitochondrial membranes (CoA, L-ornithine, Mg2+), regulation of mitochondrial membrane permeability, and cellular responses tied to insulin/IGF signaling with liver regeneration, plus links to necroptosis regulation. This combination points to a functional theme of mitochondrial transport/metabolism and metabolic signaling, rather than a single specific pathway. ","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":13},{"id":"GO:0097274","count":13},{"id":"GO:0060546","count":13},{"id":"GO:0035349","count":13},{"id":"GO:0000066","count":13}]},{"hash":"146648327237048256","title":"Endocytosis and Vesicle Trafficking","description":"The top GO terms center on actin cortex assembly linked to endocytosis, multiple endosome\u2013Golgi and Golgi\u2013endosome transport steps, and targeting/sorting to vacuoles, all indicating a core function in endocytic uptake and intracellular vesicle trafficking. Some terms are unrelated or broad, but the dominant theme is vesicle trafficking and endocytosis.","confidence":"High","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0000147","count":11},{"id":"GO:0006919","count":10},{"id":"GO:0006623","count":9},{"id":"GO:0015032","count":9},{"id":"GO:0032511","count":9}]},{"hash":"1636256888088013323","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":65,"triangles":210,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":2},{"id":"GO:0043011","count":2},{"id":"GO:0009867","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0071347","count":2}]},{"hash":"911234634931245098","title":"ER Trafficking and Ubiquitin-Mediated Inflammation","description":"The dominant GO terms point to ER to Golgi transport (GO:0006888), ubiquitin-dependent ERAD (GO:0030433), regulation of protein monoubiquitination (GO:1902525), and cytokine production involved in inflammatory response (GO:0002534), indicating a cluster centered on the secretory pathway and ubiquitin-controlled immune signaling. Some terms related to DNA replication, chromosome segregation, and histone methylation appear in the list but are less coherent with this theme, suggesting possible annotation breadth or overlap; nonetheless the main signal is trafficking and ubiquitin regulation linked to inflammation.","confidence":"Medium","size":12,"edges":56,"triangles":133,"max_degree":11,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0070262","count":7},{"id":"GO:0071560","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0035690","count":4}]},{"hash":"1550644710274189626","title":"DNA replication and repair cluster","description":"The top GO terms are dominated by DNA-centric processes: DNA replication, leading strand elongation, UV-damage excision repair, and error-free translesion synthesis, along with DNA-templated transcription and positive regulation of DNA-directed DNA polymerase activity. This pattern points to a cohesive module of replication and genome-maintenance factors, with liver regeneration and heart development likely reflecting broader developmental roles of some components or context-specific expression. Overall, the cluster appears to represent DNA replication and repair machinery.","confidence":"High","size":12,"edges":60,"triangles":166,"max_degree":11,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0070914","count":4},{"id":"GO:0006272","count":4},{"id":"GO:0097421","count":4},{"id":"GO:0070987","count":4}]},{"hash":"1972278720772026214","title":"Developmental differentiation and transcriptional regulation","description":"The cluster\u2019s top GO terms center on transcriptional control (regulation of DNA-templated transcription and RNAP II\u2013mediated regulation) and on differentiation of multiple lineages (granulocytes, erythrocytes, neurons, pituitary development), with apoptosis as an additional process\u2014together pointing to gene-regulatory programs guiding development.","confidence":"Medium","size":12,"edges":17,"triangles":6,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":5},{"id":"GO:0006915","count":5},{"id":"GO:0051572","count":4},{"id":"GO:0030851","count":4},{"id":"GO:0045648","count":4}]},{"hash":"46052192233301818","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":55,"triangles":135,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0043981","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0000472","count":3}]},{"hash":"229913713942511571","title":"Chromatin Regulation and Mitosis","description":"Several top GO terms cluster around chromatin biology and cell cycle control: subtelomeric heterochromatin formation, histone demethylation, and G2/M transition with mitotic spindle elongation. Ubiquitination events (nuclear polyubiquitination and K29-linked ubiquitination) often regulate degradation of cell-cycle and chromatin regulators, reinforcing a chromatin- and mitosis-centric theme. Some terms related to peroxisome import, fungal cell wall organization, and C-type lectin signaling appear as outliers, likely annotation noise or multifunctional proteins, but the core signal points to chromatin remodeling tied to mitotic progression.","confidence":"Medium","size":12,"edges":52,"triangles":118,"max_degree":11,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0006348","count":11},{"id":"GO:1901044","count":11},{"id":"GO:0000022","count":11},{"id":"GO:0070076","count":11},{"id":"GO:0035519","count":11}]},{"hash":"1839503171464327313","title":"Neuronal development with cytoskeleton and mitochondria regulation","description":"The cluster centers on neuron projection development and microtubule dynamics (bundle formation and polymerization) and includes mitochondrial regulation and calcium signaling terms, pointing to a module where neurite outgrowth is coordinated with cytoskeletal remodeling and mitochondrial function.","confidence":"Medium","size":12,"edges":29,"triangles":35,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":3},{"id":"GO:1903748","count":2},{"id":"GO:0001578","count":2},{"id":"GO:1905689","count":2},{"id":"GO:0031175","count":2}]},{"hash":"863303030584031656","title":"Mitophagy Regulators","description":"Most representative terms are autophagy of mitochondrion and its regulation (positive and negative), indicating the cluster centers on mitochondrial autophagy/mitophagy control and mitochondrial quality maintenance. Additional terms touch on mitochondrial targeting, protein modification, and lipid metabolism, suggesting these proteins participate in broader mitochondrial homeostasis with a focus on mitophagy-related regulation. Given the clear mitophagy signals but limited broader concordance, the label is informative but not exclusive.","confidence":"Medium","size":12,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000422","count":1},{"id":"GO:1903204","count":1},{"id":"GO:0045620","count":1},{"id":"GO:0006626","count":1},{"id":"GO:1903599","count":1}]},{"hash":"159496216563577426","title":"RNA processing and post-transcriptional regulation","description":"The cluster is driven by post-transcriptional control: splicing regulation via the spliceosome, mRNA export, translational initiation regulation, and regulatory ncRNA\u2013mediated gene silencing, which together point to RNA processing and control of mRNA fate. Some tissue-specific terms (neural retina development, hair follicle maturation) may reflect context rather than core function. Overall, the proteins appear linked to RNA processing, splicing, and translation regulation.","confidence":"High","size":12,"edges":62,"triangles":183,"max_degree":11,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1900363","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0006406","count":3}]},{"hash":"1063975173991325068","title":"RNA processing and translation initiation","description":"The cluster is dominated by GO terms related to RNA processing and protein synthesis, including translation, translation initiation, and formation of cytoplasmic translation initiation complexes, as well as RNA splicing and spliceosomal disassembly. A few outlier terms (e.g., host-mediated viral genome activation and MHC biosynthesis regulation) are minor and do not override the core themes. Thus, the label reflects the main functions represented by the proteins.","confidence":"Medium","size":12,"edges":53,"triangles":120,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006379","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0001732","count":2},{"id":"GO:0006413","count":2},{"id":"GO:1904876","count":1}]},{"hash":"108789177599676070","title":"Ribosome biogenesis and DNA replication","description":"Many proteins in this cluster are linked to ribosome biogenesis and assembly (ribosomal small subunit biogenesis/assembly) and translation-related RNA processing (tRNA wobble uridine modification). Concurrently, DNA replication and cell cycle terms point to roles in genome duplication and cell proliferation. Iron-sulfur cluster assembly and ribosome-related processes further support a coordinated function in building the translational machinery alongside DNA replication; the obsolete terms are minor notes and do not change the core theme. ","confidence":"High","size":12,"edges":47,"triangles":89,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:0045226","count":3},{"id":"GO:0016226","count":3},{"id":"GO:0002098","count":3},{"id":"GO:0019079","count":2}]},{"hash":"635090858944060006","title":"Innate immune signaling and nociception","description":"This cluster centers on innate immune pathways (NOD2 signaling, NF-kappaB regulation, protein ubiquitination) together with sensory stress responses (pain and temperature detection, mechanical stimulus). Calcium release links signaling to responses, supporting a theme of immune-sensory cross-talk. A few terms (e.g., oligodendrocyte differentiation) appear less central, likely noise or broader roles, but do not overturn the core theme. ","confidence":"Medium","size":12,"edges":14,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0032088","count":3},{"id":"GO:0051209","count":2}]},{"hash":"389915051248205541","title":"Bacterial biosynthesis and sporulation","description":"The co-occurrence of sporulation, antibiotic biosynthesis, and fatty acid biosynthesis, along with various catabolic and transport terms, suggests a microbial metabolism/sporulation-focused cluster. Although several terms are obsolete, the remaining GOs point to a bacterial biosynthetic/metabolic module with involvement in sporulation.","confidence":"Medium","size":12,"edges":54,"triangles":127,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0030435","count":4},{"id":"GO:0019878","count":4},{"id":"GO:1902987","count":4},{"id":"GO:0017000","count":4}]},{"hash":"564899502606197793","title":"Mitotic chromosome dynamics and division","description":"This cluster is dominated by GO terms tied to mitosis, including mitotic metaphase chromosome alignment, chromosome condensation, and exit from mitosis, plus a general cell division term. The presence of membrane remodeling terms (ESCRT-mediated budding and membrane fission) aligns with cytokinesis-related membrane scission, while some developmental terms may reflect cell-cycle roles in tissue development. Overall, the proteins appear to center on mitotic chromosome dynamics and cell division, hence the chosen label.","confidence":"Medium","size":12,"edges":49,"triangles":98,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0007080","count":5},{"id":"GO:0007076","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0039702","count":3},{"id":"GO:0030447","count":3}]},{"hash":"1980423462975309704","title":"Cardiac lipid metabolism and development","description":"The top GO terms point to fatty acid oxidation and carnitine-related metabolism (e.g., fatty acid beta-oxidation, medium-chain fatty acid catabolic process, carnitine biosynthetic and metabolic processes) together with heart-specific development terms (heart development, cardiac muscle differentiation, post-embryonic development). This suggests a coherent theme of lipid-energy metabolism in cardiac tissue and associated developmental processes, with one outlier term that is less aligned but not enough to change the overall interpretation.","confidence":"High","size":12,"edges":43,"triangles":71,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:1904070","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0006693","count":4},{"id":"GO:0033540","count":4},{"id":"GO:0045329","count":3}]},{"hash":"1736380788427286984","title":"Cartilage development and endochondral ossification","description":"This cluster is enriched for terms tied to cartilage formation and bone development via endochondral ossification, including chondrocyte development, cartilage development, and matrix sulfation, with some regulation of ossification terms. While there are a few more general developmental terms, the dominant theme points to skeletal cartilage formation and ossification processes.","confidence":"High","size":12,"edges":23,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":2},{"id":"GO:0002003","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0036011","count":1}]},{"hash":"897860905502535804","title":"Cytokine-Driven Cardio-Immune Regulation","description":"The top GO terms center on cytokine/immune signaling (GM-CSF response, LPS response, interferon production) and cardiovascular regulation (vascular permeability, cardiac muscle relaxation, hypertrophy), suggesting proteins that mediate cytokine effects on immune responses and heart/vascular function; other terms like lipid metabolism and serotonin are ancillary but compatible with this integrated signaling theme.","confidence":"Medium","size":12,"edges":27,"triangles":19,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":4},{"id":"GO:0050995","count":4},{"id":"GO:0043116","count":4},{"id":"GO:1901898","count":4},{"id":"GO:0060282","count":4}]},{"hash":"1030713924200030950","title":"Methionine salvage and threonine biosynthesis","description":"This cluster is driven by amino acid metabolism signals, with two GO terms for L-methionine salvage from methylthioadenosine/S-adenosylmethionine and one for L-threonine biosynthesis as top terms. While there are a few other annotations (phosphorylation, transcription regulation, histone modification) that are less representative, the dominant theme points to methionine salvage and threonine biosynthesis in the proteins.","confidence":"Medium","size":12,"edges":17,"triangles":10,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019509","count":7},{"id":"GO:0046677","count":7},{"id":"GO:0009088","count":7},{"id":"GO:0019284","count":7},{"id":"GO:0016310","count":7}]},{"hash":"1787556869541009327","title":"RNA processing and translation initiation","description":"This cluster is enriched for post-transcriptional RNA metabolism (mRNA stabilization, spliceosome-associated splicing, and polyadenylation) and translation initiation components (eIF4F complex assembly and IRES-dependent viral initiation), suggesting a cohesive theme around RNA processing coupled to translation control.","confidence":"High","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048255","count":3},{"id":"GO:0034462","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0000381","count":3},{"id":"GO:1900363","count":3}]},{"hash":"647294835884527798","title":"Stress-Responsive Lipid Metabolism","description":"The cluster is dominated by lipid metabolic processes (cholesterol biosynthetic process, fatty acid oxidation) and stress-response GO terms (response to toxic substance, nitrosative stress, innate immune response), suggesting a cohesive theme around lipid metabolism linked to cellular stress signaling and proliferation. Some terms (e.g., visual perception) are peripheral, but the core signals point to metabolism intertwined with stress responses. ","confidence":"Medium","size":12,"edges":21,"triangles":15,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006695","count":8},{"id":"GO:0009636","count":8},{"id":"GO:0019395","count":7},{"id":"GO:0071375","count":7},{"id":"GO:0071372","count":7}]},{"hash":"1817420385973304839","title":"Unknown","description":"The GO terms are highly diverse, spanning spliceosome dynamics, development in lung and kidney, hematopoietic proliferation, neural guidance, receptor signaling and internalization, and immune response. There is no unifying biological process or pathway evident among the terms, and these proteins do not cluster around a single function. Thus, no concise, representative label can be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000388","count":1},{"id":"GO:0010226","count":1},{"id":"GO:0048286","count":1},{"id":"GO:1902035","count":1},{"id":"GO:0072224","count":1}]},{"hash":"412921026588051827","title":"Mesenchymal Development and Adipogenesis","description":"The cluster\u2019s top GO terms cluster around developmental processes and differentiation, notably fat cell differentiation, face development, and cell migration/adhesion, with supporting transcriptional regulation and cell-cycle control. This suggests a shared theme of mesenchymal development progressing toward adipogenic differentiation, possibly contributing to craniofacial structures. Therefore the label reflects the main functional theme without being overly broad.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0035994","count":4},{"id":"GO:0032298","count":3},{"id":"GO:0006397","count":3},{"id":"GO:0016477","count":3}]},{"hash":"1731331930726907530","title":"Tissue development and angiogenesis","description":"The terms point to developmental and vascular processes: retina vasculature development, mammary gland development, and both general and positive regulation of angiogenesis. These together suggest a cluster enriched for tissue morphogenesis and blood vessel formation. Minor terms like long-term synaptic potentiation or response to toxic substances appear less central and do not redefine the main theme.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061298","count":3},{"id":"GO:0030879","count":3},{"id":"GO:0009636","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0001525","count":2}]},{"hash":"1060116079285836657","title":"Unknown","description":"The top GO terms are disparate and largely obsolete or singleton, with no clear shared function linking the proteins. They span immune regulation, aging, metabolism, reproduction, development, and neurotransmitter catabolism, and there are no edges or cohesive pathway signals to tie these proteins together, so a single representative function cannot be inferred.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902564","count":1},{"id":"GO:0051573","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0061732","count":1},{"id":"GO:0009229","count":1}]},{"hash":"386900082224984584","title":"Embryonic Development and Morphogenesis","description":"The terms point to embryogenesis and tissue morphogenesis: left/right pattern formation, cartilage morphogenesis, trophoblast differentiation, EMT in endocardial cushion formation, and endocrine system development. These together suggest a developmental/organogenesis theme for the cluster, with a couple outliers (phylloquinone biosynthesis, spliceosome activity) that are less central to the core pattern. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0060536","count":2},{"id":"GO:0060707","count":2},{"id":"GO:0003198","count":2}]},{"hash":"1624885583787421202","title":"Unknown","description":"The Top Terms come from a highly diverse set of processes across different kingdoms (hormone biosynthesis, lipid and sphingolipid pathways, plant alkaloid biosynthesis, bacterial PHB production, phylloquinone catabolism, development, and general stress responses). There is no clear shared function or domain that unifies these terms into a single coherent cluster function, so a specific label with confidence cannot be established.","confidence":"","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008209","count":12},{"id":"GO:0006666","count":12},{"id":"GO:0042619","count":12},{"id":"GO:0042376","count":12},{"id":"GO:0009710","count":12}]},{"hash":"2297863072413857648","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032516","count":2},{"id":"GO:0032361","count":2},{"id":"GO:0071318","count":2},{"id":"GO:0097755","count":2},{"id":"GO:0006874","count":2}]},{"hash":"145230151387548989","title":"Mitochondrial protein import and respiratory chain assembly","description":"The top GO terms cluster around importing proteins into mitochondrial compartments (inner membrane and matrix) and assembly of the respiratory chain (complex IV) plus proton transport, suggesting a coherent role in mitochondrial targeting and respiration. A chloroplast import term appears as an outlier, but does not override the mitochondrial-centric theme. Other terms are broad or peripheral and do not define the core function.","confidence":"Medium","size":12,"edges":45,"triangles":84,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":3},{"id":"GO:0045037","count":2},{"id":"GO:0032094","count":2},{"id":"GO:0000002","count":2},{"id":"GO:0030150","count":2}]},{"hash":"260585164481422094","title":"Transmembrane Transporters","description":"The top GO terms point to a broad set of transmembrane transport activities, including xenobiotic, nitrate/nitrite, ion, sugar, vitamin, and antibiotic transport, plus neurotransmitter loading into vesicles. This suggests the proteins are membrane transporters with diverse substrates, rather than a single enzymatic function. The convergence on \u201ctransmembrane transport\u201d terms makes this a coherent and representative label.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0042128","count":5},{"id":"GO:0006004","count":5},{"id":"GO:0015707","count":5},{"id":"GO:0035725","count":5}]},{"hash":"1791402707400729984","title":"Adenylate Cyclase-Activating GPCR Signaling","description":"The top GO terms cluster around receptors that activate adenylate cyclase (Gs-coupled GPCR signaling) and downstream ERK activation, with related themes in circadian regulation, immune cell chemotaxis, and platelet activation, plus associated physiological responses like gastric acid secretion. This suggests a cohesive functional unit centered on GPCR-mediated signaling leading to cAMP and ERK pathway activation across multiple cell types. ","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001698","count":12},{"id":"GO:0072224","count":12},{"id":"GO:0048290","count":12},{"id":"GO:0042752","count":12},{"id":"GO:0071880","count":12}]},{"hash":"2100316693055284079","title":"Neurodevelopment","description":"Most top GO terms cluster around brain development and morphogenesis (telencephalon development, neural retina development, cerebellar cortex morphogenesis) and related transcription activity, suggesting a function centered on neurodevelopment. Additional terms reference development of other organs (thymus, pancreatic epsilon cells) and cellular responses, indicating broader developmental regulation but with a neural emphasis.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0021537","count":3},{"id":"GO:0060038","count":3},{"id":"GO:0035994","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0048538","count":2}]},{"hash":"1253967384980494400","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":38,"triangles":80,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":7},{"id":"GO:0016567","count":6},{"id":"GO:0042787","count":6},{"id":"GO:0031146","count":6},{"id":"GO:0006293","count":5}]},{"hash":"1606140251698576447","title":"Neurodevelopmental signaling and morphogenesis","description":"The cluster centers on neural development signals (neural tube closure, forebrain development) with supporting morphogenetic and growth signaling (Rho pathway, PDGF receptor signaling, PI3K activity) and regulation of apoptosis and cell cycle, suggesting a cohesive theme of developmental signaling guiding neural and organ morphogenesis, despite some immune-related term (IL-4 production) present as a broader regulatory context.","confidence":"Medium","size":11,"edges":25,"triangles":23,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0034351","count":4},{"id":"GO:0031532","count":4},{"id":"GO:2000727","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0030900","count":4}]},{"hash":"541657386166261895","title":"Cell Cycle Regulation and Ubiquitin-Dependent Proteolysis","description":"The cluster is enriched for GO terms around mitotic and meiotic control, including G1/S and G2/M transitions, metaphase/anaphase transition, and sister chromatid movement, along with ubiquitin-dependent protein catabolic process. This points to coordinated cell cycle regulation and targeted protein degradation as the core function of the proteins, with some germline/developmental terms possibly reflecting broader roles in growth of the egg chamber or sex determination in this context.","confidence":"High","size":11,"edges":27,"triangles":29,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0019102","count":4},{"id":"GO:1902104","count":4},{"id":"GO:0031915","count":4},{"id":"GO:0007295","count":4}]},{"hash":"140717693221644429","title":"Viral replication and virion assembly","description":"The top GO terms are dominated by virion assembly, viral life cycle, and viral release from host cell, indicating these proteins participate in viral replication and assembly processes; other terms reflect host-virus interaction and proviral latency, with a few general protein-folding terms likely incidental. ","confidence":"High","size":11,"edges":24,"triangles":21,"max_degree":7,"top_function":"protein folding","top_go_terms":[{"id":"GO:0019068","count":6},{"id":"GO:2000276","count":4},{"id":"GO:0006457","count":4},{"id":"GO:1901407","count":4},{"id":"GO:0019076","count":4}]},{"hash":"488057420731810656","title":"Antiviral Innate Immunity and Autophagy","description":"This cluster centers on innate antiviral defense and autophagy: terms include defense response to virus, negative regulation of viral transcription, suppression of viral release, and autophagy, with NF-kappaB signaling also involved. A broader link to LPS-mediated signaling reinforces the theme of innate immune activation and intracellular handling of viral components, often linked to microtubule-associated transport.","confidence":"High","size":11,"edges":49,"triangles":122,"max_degree":10,"top_function":"autophagy","top_go_terms":[{"id":"GO:0031664","count":3},{"id":"GO:0051607","count":3},{"id":"GO:0032897","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0030433","count":3}]},{"hash":"2007690422417394618","title":"Meiosis and Chromosome Segregation","description":"The cluster is dominated by meiosis-related processes (meiotic chromosome separation, synaptonemal complex assembly) and general cell division, with additional terms suggesting nucleolar/chromosome maintenance; other terms reflect broader trafficking and are less central to the core theme.","confidence":"Medium","size":11,"edges":25,"triangles":20,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0070058","count":2},{"id":"GO:0009959","count":2},{"id":"GO:0043007","count":2},{"id":"GO:0051307","count":2}]},{"hash":"1396630226689733495","title":"RNA Splicing and Transcription Regulation During Development","description":"The cluster is dominated by GO terms for mRNA splicing via the spliceosome (e.g., GO:0000398, GO:0045292) and regulation of transcription (GO:0006355, GO:0006351, GO:0006378), indicating a core theme of RNA processing and transcription control. Developmental terms are also present (e.g., multicellular organism development, blastocyst formation, embryonic differentiation), suggesting the proteins participate in gene expression programs during development. Translation initiation terms appear but are secondary. Confidence: High","confidence":"","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0035165","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0001825","count":2}]},{"hash":"1528381369283822461","title":"Neural synaptic development and signaling","description":"This cluster is dominated by terms related to neuronal synapse function (excitatory postsynaptic potentials, glutamatergic transmission, GKAP clustering) and cytoskeletal/adhesion dynamics (lamellipodium assembly, cell spreading), pointing to roles in synapse formation and neuronal connectivity. The other developmental terms (bone, palate, adipose) may reflect broader pleiotropic roles of these proteins across tissues. Confidence: Medium","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030032","count":4},{"id":"GO:2000463","count":3},{"id":"GO:1904179","count":3},{"id":"GO:0097117","count":3},{"id":"GO:0060022","count":3}]},{"hash":"858853544624157472","title":"Actin cytoskeleton remodeling and cell morphogenesis","description":"The top terms emphasize actin-driven structures (filopodium, microspike), Rho signaling, and cell morphogenesis, with additional development-related terms, suggesting a cohesive theme of cytoskeletal dynamics governing shape changes and signaling across tissues.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007099","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0000902","count":2},{"id":"GO:0043552","count":2}]},{"hash":"1851574368309138137","title":"Embryonic organ and neural morphogenesis","description":"The cluster centers on embryonic development across multiple organs (heart, hindlimb, eye, gonad) and neural patterning (neuron migration, axon guidance), with additional notes on behavior. This suggests a cohesive theme of early organogenesis and neural morphogenesis, making the label Embryonic organ and neural morphogenesis appropriate and representative.","confidence":"High","size":11,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":6},{"id":"GO:0008045","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0001759","count":4},{"id":"GO:0003148","count":4}]},{"hash":"2107298849984901887","title":"Membrane trafficking and signaling regulation","description":"Explanation: The dominant themes are membrane trafficking (Golgi vesicle docking, melanosome transport, protein localization to the plasma membrane) and regulation of signaling (regulation of protein kinase activity, negative regulation of gene expression). Other terms (mitochondrial membrane organization, ameboid migration, hair follicle morphogenesis) suggest broader roles in organelle dynamics and development, but the central tie appears to be coordinated trafficking and membrane-associated signaling.","confidence":"Medium","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010629","count":11},{"id":"GO:0001667","count":11},{"id":"GO:0045859","count":11},{"id":"GO:0000186","count":11},{"id":"GO:1903078","count":11}]},{"hash":"643736091295282893","title":"Unknown","description":"Top terms include symbiont entry into host cell, cellulose catabolic process, detoxification, and various cell movement or behavior terms; these functions are heterogeneous and do not point to a single coherent theme for the cluster.","confidence":"","size":11,"edges":31,"triangles":37,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":3},{"id":"GO:0030245","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0007155","count":2},{"id":"GO:1902362","count":2}]},{"hash":"2121398165049462364","title":"Unknown","description":"The GO terms span diverse developmental processes (ear, kidney, pharyngeal system) and stress/signaling responses (UV response, cytokine stimulus, senescence) plus ion homeostasis, with no single unifying function. The lack of edges suggests no cohesive cluster to label.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043583","count":1},{"id":"GO:0001822","count":1},{"id":"GO:0008355","count":1},{"id":"GO:0071493","count":1},{"id":"GO:0090399","count":1}]},{"hash":"630187087457524409","title":"Epigenetic transcriptional repression","description":"The terms center on chromatin-based gene silencing: negative regulation of transcription by RNA polymerase II, DNA methylation, and histone modifications (H3-K27 trimethylation, H3-K23 acetylation). This suggests the proteins act together to repress transcription via epigenetic mechanisms, despite some ancillary terms.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0010216","count":2},{"id":"GO:0043972","count":2},{"id":"GO:1901536","count":2},{"id":"GO:0098532","count":2}]},{"hash":"289858665952608653","title":"Amino acid sensing and TOR signaling","description":"Dominant GO terms point to amino acid metabolism and nutrient sensing (L-phenylalanine catabolic process, cellular response to amino acid stimulus) and TOR signaling, with supporting protein processing roles (proteolysis, deglycosylation) and regulation of GTPase activity; a couple terms (brain development, viral genome replication) are less connected.","confidence":"Medium","size":11,"edges":12,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006559","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0033345","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0007420","count":2}]},{"hash":"691672388960582504","title":"Developmental Cytoskeletal Regulation","description":"The cluster's proteins show enrichment for cytoskeletal processes (intermediate filament bundle assembly, pseudopodium assembly, microtubule dynamics), GTPase regulatory activity, directional/anisotropic growth, and developmental processes such as dorsal identity determination and oviduct development, plus nuclear transport and organelle junction assembly, suggesting a cohesive theme of developmental cytoskeletal remodeling and cell polarity.","confidence":"High","size":11,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:2000017","count":2},{"id":"GO:0045110","count":2},{"id":"GO:0060066","count":2},{"id":"GO:0051211","count":2}]},{"hash":"1109329458517366285","title":"Microtubule dynamics and vesicle trafficking","description":"The top GO terms point to plus-end-directed and retrograde vesicle transport along microtubules, cytoplasmic microtubule organization, and tubulin folding, suggesting a cluster of proteins involved in microtubule-based transport and cytoskeletal regulation. Some terms relate to cell-cycle\u2013associated nuclear events, but the prevalent theme is microtubule dynamics and trafficking.","confidence":"Medium","size":11,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0072383","count":5},{"id":"GO:0007023","count":4},{"id":"GO:0048491","count":4},{"id":"GO:0031115","count":4},{"id":"GO:0043369","count":4}]},{"hash":"310961918980745100","title":"Embryonic kidney and vascular branching morphogenesis","description":"The GO terms cluster around branching morphogenesis in the kidney (ureteric bud branching, metanephric development) and vascular development (lymphangiogenesis, venous vessel morphogenesis, endothelial chemotaxis), with embryo development and ERK signaling regulation supporting coordinated morphogenesis. This points to a theme of embryonic development involving kidney and vascular branching. ","confidence":"Medium","size":11,"edges":9,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001658","count":1},{"id":"GO:0001946","count":1},{"id":"GO:0048845","count":1},{"id":"GO:0060683","count":1},{"id":"GO:0035767","count":1}]},{"hash":"143860273304211612","title":"GPI anchor biosynthesis and sugar metabolism under osmotic stress","description":"This cluster centers on ER-associated glycan processing and membrane glycan assembly. Key terms include obsolete but informative GO:0033577 (protein glycosylation in ER), GO:0006506 (GPI anchor biosynthesis), and GO:0009247 (glycolipid biosynthetic process), as well as sugar metabolism (GO:0005985, GO:0006006). The presence of osmotic/stress response terms (GO:0009413, GO:0009414, GO:0072708) and feeding behavior (GO:0007631) suggests a group of proteins tied to membrane/secreted glycoprotein and glycolipid synthesis whose activity is modulated by osmotic stress or nutritional cues. Therefore the label captures the core themes.","confidence":"Medium","size":11,"edges":19,"triangles":20,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0033577","count":6},{"id":"GO:0006506","count":4},{"id":"GO:0009247","count":4},{"id":"GO:0009413","count":4},{"id":"GO:0005985","count":4}]},{"hash":"2012349391998647891","title":"Developmental Signaling and Morphogenesis","description":"These proteins appear to participate in growth-related signaling and tissue patterning, with GO terms spanning larval cuticle development, heart development, axon guidance, synapse localization, cell-matrix adhesion, and various signaling pathways (growth hormone receptor signaling, Rho signaling, and SMAD-related processes). The shared theme is coordinating development through signaling cascades that shape neural and cardiac tissues and their connections.","confidence":"Medium","size":11,"edges":26,"triangles":24,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0043113","count":2},{"id":"GO:0030579","count":2},{"id":"GO:0007160","count":2}]},{"hash":"1656353635838428672","title":"Proteasome Assembly","description":"The cluster is labeled Proteasome Assembly because its top GO term is proteasome assembly (GO:0043248), indicating the proteins are associated with assembling the proteasome complex; even without network edges, the annotation supports a cohesive assembly-related function.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1}]},{"hash":"1084803612165105683","title":"Acetylation-driven Chromatin Regulation","description":"The cluster shows enrichment for PTM-related acetylation terms (N-terminal propionylation and peptidyl-lysine N6-acetylation) together with subtelomeric heterochromatin formation, suggesting a core theme around acetylation-controlled chromatin states. Other metabolic and development-related terms are present but appear ancillary to the acetylation/chromatin signaling pattern, leading to a moderately confident, cohesive label focused on chromatin regulation via acetylation.","confidence":"Medium","size":11,"edges":53,"triangles":148,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0030187","count":10},{"id":"GO:0006348","count":10},{"id":"GO:0019491","count":10},{"id":"GO:2000025","count":10},{"id":"GO:0009447","count":10}]},{"hash":"1883790096935197242","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0034553","count":2},{"id":"GO:0010719","count":1},{"id":"GO:0006105","count":1},{"id":"GO:0006121","count":1}]},{"hash":"1820235684492651224","title":"Neuronal projection growth and microtubule regulation","description":"The cluster is dominated by GO terms tied to neuron projection development and axonogenesis, along with many entries about microtubule polymerization/depolymerization and their regulation, plus a cellular response to nerve growth factor\u2014collectively pointing to neuronal outgrowth governed by microtubule dynamics. A single cardiolipin biosynthesis term stands out as a possible annotation artifact or incidental mitochondrial-associated function, but it does not define the core theme of neurite/axon growth. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032049","count":2},{"id":"GO:0007019","count":1},{"id":"GO:0031117","count":1},{"id":"GO:0010977","count":1},{"id":"GO:0007409","count":1}]},{"hash":"1079573542395533954","title":"Dopaminergic Signaling and Transcription Regulation","description":"This cluster centers on GO terms related to dopaminergic synaptic transmission and regulatory pathways that lead to changes in gene expression, including ERK/MAPK signaling and transcription by RNA polymerase II, as well as epigenetic and protein turnover processes (histone acetylation and proteasome-mediated degradation). The combination suggests a theme where dopamine signaling influences transcriptional responses and protein turnover, tying neuronal signaling to gene expression changes. Some outlier terms exist, but the predominant pattern is dopaminergic signaling linked to transcriptional regulation.","confidence":"Medium","size":11,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032092","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0042595","count":1},{"id":"GO:0032226","count":1},{"id":"GO:0045944","count":1}]},{"hash":"1718949283579529706","title":"Cardiac conduction and gap junction regulation","description":"This cluster is anchored by direct GO terms related to cardiac electrical function: regulation of cardiac conduction and regulation of gap junction assembly, pointing to heart-specific electrical coupling. Additional terms like cell adhesion and protein tyrosine kinase activity support intercellular signaling and communication, while triglyceride catabolic process and fibrinolysis-related terms may reflect broader vascular/metabolic contexts. Overall, the core theme centers on heart-specific electrical connectivity and coordination between cells.","confidence":"High","size":11,"edges":13,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071307","count":2},{"id":"GO:1904209","count":2},{"id":"GO:0008283","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0019433","count":2}]},{"hash":"1122490303644780815","title":"Innate Immune Signaling and Antigen Presentation","description":"The top GO terms cluster around innate immune receptor pathways (NOD2 signaling, TLR4 signaling) and NF-kB regulation, plus dendritic cell antigen processing and presentation and TH17 differentiation, pointing to immune recognition and activation. Some terms are ancillary (circadian regulation, cornea development) or obsolete, but the dominant theme is innate immune signaling with antigen presentation.","confidence":"High","size":11,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070431","count":4},{"id":"GO:0032088","count":4},{"id":"GO:0000083","count":3},{"id":"GO:0009408","count":3},{"id":"GO:0061303","count":2}]},{"hash":"535563185312170228","title":"Insect larval cuticle development and vesicle trafficking","description":"The strongest signal is larval chitin-based cuticle development, indicating insect cuticle formation. The presence of endosome/lysosome localization and endosome-to-melanosome transport terms supports a theme of intracellular vesicle trafficking contributing to development. Some terms (visual perception, virion attachment, VEGF signaling) are less cohesive with the main pattern but do not override the core signal.","confidence":"Medium","size":11,"edges":10,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":5},{"id":"GO:0007601","count":2},{"id":"GO:0046813","count":1},{"id":"GO:2000145","count":1},{"id":"GO:0061462","count":1}]},{"hash":"1176637252676626617","title":"Unknown","description":"The terms in this cluster are highly heterogeneous, including immune/LPS detection and response, TNF production, lipid and iron metabolism (cholesterol efflux, transferrin transport, iron homeostasis), sensory/pheromone detection, plant development (inflorescence meristem growth), and post-translational modification (deglutamylation). There is no clear, single biological process or pathway tying these together, so a specific functional label is not justifiable. Therefore, the appropriate label is Unknown with no confidence in a representative function.","confidence":"","size":11,"edges":7,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032497","count":2},{"id":"GO:0032760","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0033344","count":2},{"id":"GO:0043695","count":2}]},{"hash":"1949670335489188101","title":"Neural development and synaptic signaling","description":"The top terms collectively highlight nervous system development, axon guidance, synapse structure/activity regulation, and neuron-specific signaling (including ionotropic glutamate receptor pathways), pointing to a coherent theme of neural connectivity and synaptic maturation; occasional terms about morphogenesis and amyloid formation seem tangential but do not override the neural-focused cluster.","confidence":"High","size":11,"edges":47,"triangles":111,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":11},{"id":"GO:1990000","count":11},{"id":"GO:0048669","count":11},{"id":"GO:0035235","count":11},{"id":"GO:0060670","count":11}]},{"hash":"1681648335126721357","title":"Chromatin Remodeling and Histone Deacetylation","description":"The cluster shows strong enrichment for chromatin-related processes: chromatin remodeling, rDNA heterochromatin formation, nucleosome density regulation, histone deacetylation, and regulation of DNA double-strand break repair via homologous recombination, suggesting a cohesive role in shaping chromatin state and coordinating transcription and DNA repair.","confidence":"High","size":10,"edges":18,"triangles":12,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000183","count":5},{"id":"GO:1990414","count":4},{"id":"GO:0060303","count":4},{"id":"GO:0043044","count":3},{"id":"GO:0010569","count":3}]},{"hash":"1947214864637622990","title":"Neural and vascular development signaling","description":"Most terms cluster around developmental growth and signaling, notably nervous system development, angiogenesis, and PDGF receptor signaling. Visual perception hints at eye/retinal neural development, while mitotic cell cycle involvement aligns with proliferative tissue development.","confidence":"Medium","size":10,"edges":30,"triangles":40,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":8},{"id":"GO:0000278","count":8},{"id":"GO:2001275","count":7},{"id":"GO:1904637","count":6},{"id":"GO:0000186","count":6}]},{"hash":"246233505719540609","title":"Autophagy and Endosome-Lysosome Trafficking","description":"This cluster centers on vesicle trafficking routes to the lysosome/vacuole and autophagy, including endosome-to-lysosome transport, Golgi-to-endosome transport, vesicle tethering, and vesicle fusion with the vacuole, plus autophagosome maturation. A few RNA-decay terms appear, suggesting a broader connection to cellular quality control housed in degradation pathways. Overall, the dominant signal is autophagy and lysosomal/vacuolar degradation processes.","confidence":"Medium","size":10,"edges":34,"triangles":54,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0070651","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0008333","count":2},{"id":"GO:0006895","count":2}]},{"hash":"2231297007815304665","title":"Mitotic cell cycle and spindle assembly","description":"The top GO terms cluster around cell division, including mitotic cell cycle, mitotic spindle assembly, and Okazaki fragment processing during mitotic DNA replication, with supporting signals from nuclear transport and cytoskeletal dynamics, indicating a cohesive theme of mitosis and cell-cycle regulation.","confidence":"High","size":10,"edges":26,"triangles":29,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:1903461","count":5},{"id":"GO:0031081","count":5},{"id":"GO:0000278","count":5},{"id":"GO:1904263","count":5}]},{"hash":"1552962384684668626","title":"Spliceosome Regulation and mRNA Processing","description":"The cluster is enriched for GO terms tied to RNA processing and post-transcriptional regulation, especially splicing via the spliceosome (positive regulation and alternative splicing), mRNA stabilization, and small-subunit processome assembly. This points to a cohesive group of proteins involved in RNA maturation and fate rather than transcription initiation, with a few translation-related terms that may reflect broader RNA metabolism links. ","confidence":"Medium","size":10,"edges":39,"triangles":80,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":4},{"id":"GO:0031047","count":4},{"id":"GO:0048255","count":3},{"id":"GO:0034462","count":3},{"id":"GO:1901407","count":3}]},{"hash":"1292371300183956263","title":"RNA processing and ribosome biogenesis","description":"This cluster is enriched for RNA processing and protein synthesis functions: multiple GO terms cover mRNA splicing (including regulation via spliceosome), mRNA export, and rRNA/spliceosome-related processing, alongside ribosome biogenesis and translation initiation/reinitiation. Together these signals suggest a cohesive group of proteins involved in RNA maturation and assembly of the ribosome/translation machinery, with some ancillary links to cell division and development. ","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000381","count":3},{"id":"GO:0006406","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0051301","count":2}]},{"hash":"831857306628185612","title":"Plant DNA replication and chromatin regulation in growth","description":"This cluster centers on core DNA replication and DNA damage response (replication checkpoint signaling, UV-damage excision repair) and chromatin-related processes (histone methylation/deacetylation, subtelomeric heterochromatin formation). It also includes plant growth and development signals (abscisic acid and cytokinin responses, seed and vegetative growth), suggesting a cohesive theme: plant-specific coordination of DNA replication/repair with chromatin regulation during growth and development.","confidence":"High","size":10,"edges":42,"triangles":97,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0033314","count":3},{"id":"GO:0070914","count":2},{"id":"GO:0051571","count":2},{"id":"GO:1905615","count":2}]},{"hash":"511811132146332346","title":"Cell cycle and RNA processing during stress","description":"Based on GO terms, the cluster centers on cell division and chromosome dynamics (mitosis/meiosis) together with RNA processing (splicing, mRNA stability) and translation initiation, especially in stress contexts such as hypoxia. This points to coordinated regulation of cell cycle progression and gene expression under stress, with a minor developmental/ morphogenesis component.","confidence":"Medium","size":10,"edges":42,"triangles":97,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000398","count":2},{"id":"GO:0010610","count":2},{"id":"GO:0071456","count":2},{"id":"GO:0002188","count":2}]},{"hash":"1833750178949739411","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":37,"triangles":73,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":3},{"id":"GO:0030420","count":3},{"id":"GO:0098789","count":3},{"id":"GO:0006369","count":3},{"id":"GO:0035194","count":3}]},{"hash":"532397097132239552","title":"RNA and Protein Methylation","description":"Cluster enriched for diverse methylation-related GO terms, including rRNA, tRNA, and mRNA cap methylation, as well as arginine and histone methylation, suggesting a core set of methyltransferases and RNA maturation/methylation activities. The convergence on multiple methylation processes indicates a coherent functional theme around methylation biology.","confidence":"High","size":10,"edges":28,"triangles":38,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0019919","count":4},{"id":"GO:0070476","count":4},{"id":"GO:0043985","count":4},{"id":"GO:0006370","count":4},{"id":"GO:0030488","count":4}]},{"hash":"1410522350509399865","title":"Neural Development and Sensory Organ Morphogenesis","description":"The top GO terms are dominated by neural development and sensory organ formation, including peripheral nervous system neuron development, neural crest cell migration, metencephalon development, inner ear morphogenesis, and neuronal cell type commitment. While a few terms touch broader embryonic organogenesis (pharyngeal system, ureteric bud branching, uterus development), the strongest signal is neural/sensory patterning and transcriptional regulation during development. Confidence: Medium","confidence":"","size":10,"edges":41,"triangles":94,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0048935","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0090190","count":3},{"id":"GO:0001755","count":3}]},{"hash":"1571573144019435431","title":"Unknown","description":"The terms span oxidative stress, nutrient and hypoxia responses, circadian rhythm, and sporulation, with several obsolete GO terms, indicating no single cohesive function tying the proteins together. Therefore a precise, representative label cannot be assigned.","confidence":"","size":10,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0002439","count":3},{"id":"GO:1903758","count":3},{"id":"GO:0019510","count":3},{"id":"GO:0007584","count":3}]},{"hash":"2271788859973831450","title":"Translation Initiation and Preinitiation Complex Assembly","description":"The top GO terms are dominated by translation initiation, reinitiation, and preinitiation complex formation (including IRES-driven and viral-like initiation), indicating the cluster centers on the core machinery and regulation of protein synthesis, with supporting RNA processing and stability terms that often accompany translation control.","confidence":"High","size":10,"edges":27,"triangles":33,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0075525","count":5},{"id":"GO:0075522","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0048026","count":5}]},{"hash":"2116046262858161427","title":"Secretory pathway and SNARE trafficking","description":"This cluster is dominated by GO terms tied to vesicle trafficking and secretion\u2014SNARE complex assembly, Golgi ribbon formation, and regulation of protein targeting to membranes, plus exocytic insertion of receptors and eosinophil degranulation\u2014pointing to a shared function in membrane trafficking and secretion. A couple of terms related to poly-hydroxybutyrate and antibiotic biosynthesis appear as peripheral annotations and do not define the core theme.","confidence":"Medium","size":10,"edges":9,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0042619","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0090161","count":1},{"id":"GO:1900483","count":1}]},{"hash":"1086713652736912474","title":"Glutamatergic synaptic signaling and receptor trafficking","description":"The terms point strongly to glutamatergic synapses and receptor dynamics: glutamatergic synaptic transmission, ionotropic glutamate receptor signaling, receptor clustering, and regulation/recycling of receptors, along with calcium ion transport. Developmental terms such as cerebellar granule cell differentiation and pons maturation suggest a neural development context, reinforcing a cohesive theme of CNS glutamatergic signaling and receptor regulation. This supports a specific, centralized label rather than a broad, unrelated one.","confidence":"High","size":10,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048899","count":3},{"id":"GO:0035249","count":3},{"id":"GO:0021586","count":3},{"id":"GO:0001919","count":3},{"id":"GO:0051967","count":3}]},{"hash":"1008805129098681940","title":"Central Metabolism and Biosynthesis","description":"The cluster\u2019s top GO terms are dominated by core metabolic pathways: heme biosynthesis, pteridine metabolism, the TCA cycle, glycolytic processes, acetyl-CoA biosynthesis, cholesterol biosynthesis, and polyphosphate catabolism, which together point to central carbon metabolism and biosynthetic activity. A few terms such as memory and adult locomotory behavior are likely incidental annotations and not the primary signal; overall, the group appears aligned with energy production and building block synthesis. ","confidence":"High","size":10,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006783","count":2},{"id":"GO:0019889","count":1},{"id":"GO:0006798","count":1},{"id":"GO:0006104","count":1},{"id":"GO:0006099","count":1}]},{"hash":"883819108405687243","title":"Kidney Morphogenesis and Developmental Signaling","description":"The terms cluster around embryonic development and organ morphogenesis, especially kidney-related processes such as ureteric bud branching and mesonephric duct development, plus regulatory signaling (Wnt and FGFR pathways). While a couple of terms touch on broader developmental morphogenesis, the kidney-focused terms provide a coherent core, supporting a developmental/kidney-morphogenesis theme with moderate confidence.","confidence":"Medium","size":10,"edges":16,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002003","count":2},{"id":"GO:0009631","count":2},{"id":"GO:0031133","count":2},{"id":"GO:0001658","count":2},{"id":"GO:0035116","count":2}]},{"hash":"931905326778380670","title":"Glycolysis and TCA Cycle","description":"This cluster is dominated by core energy and carbon metabolism terms: glycolytic process, canonical glycolysis, gluconeogenesis, oxaloacetate metabolism, and the TCA cycle. These points indicate a cohesive theme of central carbon metabolism and energy production. The neuronal development terms appear incidental and do not dominate the signal. Overall, the label reflects the main function of the proteins in this cluster.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006096","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0006094","count":2},{"id":"GO:0061621","count":2}]},{"hash":"1255646664978406231","title":"Actin Cytoskeleton Remodeling and Oligodendrocyte Development","description":"The top GO terms cluster around actin cytoskeleton organization, lamellipodium and filopodium assembly, and actin filament movement, indicating actin-driven membrane protrusion and cellular remodeling. The inclusion of oligodendrocyte development and positive regulation of myelination suggests this remodeling is linked to glial differentiation and myelin formation, pointing to a cohesive theme of actin dynamics guiding oligodendrocyte maturation and cytoskeletal remodeling.","confidence":"High","size":10,"edges":32,"triangles":48,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010592","count":3},{"id":"GO:0051497","count":3},{"id":"GO:0048669","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0051491","count":3}]},{"hash":"1702042105092769535","title":"Amino acid metabolism and proteolysis","description":"This cluster\u2019s GO terms repeatedly involve amino acid biosynthesis (lysine, arginine), purine nucleobase metabolism, and ureide/allantoin catabolism, along with proteolysis and vacuolar protein degradation. The shared theme appears to be nitrogen and amino acid metabolism coupled with protein turnover.","confidence":"Medium","size":10,"edges":23,"triangles":21,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0009442","count":5},{"id":"GO:0043171","count":5},{"id":"GO:0006144","count":5},{"id":"GO:0019877","count":5},{"id":"GO:0010136","count":5}]},{"hash":"664710677705396222","title":"Integrin\u2013cytoskeleton signaling with insulin pathways","description":"This cluster is dominated by GO terms related to integrin activation, regulation of integrin activation, and filopodium assembly, all pointing to actin cytoskeleton remodeling via Rho signaling. It also includes insulin receptor and IGF receptor signaling terms, suggesting a link between cytoskeletal dynamics and metabolic signaling pathways, with additional fatty acid metabolism regulation terms supporting a broader growth- and energy-related signaling context.","confidence":"Medium","size":10,"edges":32,"triangles":44,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0033622","count":2},{"id":"GO:0014065","count":2},{"id":"GO:0033623","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0010748","count":2}]},{"hash":"1138750229933562767","title":"Sphingolipid and Phospholipid Metabolism","description":"The top GO terms center on sphingolipid pathways (sphingosine and sphinganine-1-phosphate metabolism, regulation of sphingolipid signaling) and phospholipid biosynthesis/dephosphorylation, suggesting a lipid metabolism/signaling module. Some Wnt-related terms appear obsolete or non-specific and may reflect noise; the dominant signal is lipid metabolism, particularly sphingolipids and phospholipids.","confidence":"High","size":10,"edges":14,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0015760","count":3},{"id":"GO:0035233","count":3},{"id":"GO:0044328","count":3},{"id":"GO:0006655","count":3},{"id":"GO:0044329","count":3}]},{"hash":"825315186610740307","title":"Fatty acid metabolism and transport","description":"The cluster is dominated by GO terms for fatty acid metabolism and transport, including medium-chain and long-chain FA metabolism, carnitine involvement, and beta-oxidation via acyl-CoA oxidase, which provides a coherent functional theme. A few terms relate to other cellular processes (mitotic cell cycle, ovarian follicle growth, ubiquitination, Golgi retention, acetylcholine biosynthesis) that may reflect broader roles of the included proteins or pleiotropy, but fatty acid processing remains the strongest link.","confidence":"Medium","size":10,"edges":13,"triangles":3,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":3},{"id":"GO:0051791","count":2},{"id":"GO:0019254","count":2},{"id":"GO:0015909","count":2},{"id":"GO:0032000","count":2}]},{"hash":"2216551985472947597","title":"Neuronal morphogenesis and synaptic signaling","description":"The cluster centers on brain-related development and neuronal structure: hippocampus and dendrite development, lamellipodium assembly, activation of GTPase activity, and synaptic vesicle budding, which together suggest neurite outgrowth, cytoskeletal remodeling, and synaptic function. Transcriptional regulation terms may reflect neuronal gene expression control. A couple of terms about heart development and fatty acid oxidation are less connected, likely background noise. Overall, the theme points to neuronal morphogenesis and synaptic activity.","confidence":"Medium","size":10,"edges":10,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0032000","count":2},{"id":"GO:0031999","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0090630","count":2}]},{"hash":"141124938430321477","title":"Placental Vitamin Lipid Metabolism","description":"The top GO terms point to placenta development (embryonic placenta development, placenta development) and vitamin-related processes (vitamin transport, vitamin E metabolic process), with additional signals of lipid biosynthesis regulation (phosphatidylcholine and phosphatidylglycerol). Together these suggest a functional theme around placental biology tied to lipid and vitamin metabolism, justifying a label that captures both aspects. Some stress-response terms exist but are secondary to the primary placental\u2013metabolic theme.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009268","count":2},{"id":"GO:2001246","count":2},{"id":"GO:0001892","count":2},{"id":"GO:0009636","count":2},{"id":"GO:0043942","count":2}]},{"hash":"410511731923733480","title":"Immune and developmental signaling","description":"Based on GO terms, the proteins appear involved in multiple signaling pathways linked to immune function (innate immune response, T cell receptor signaling) and development (bone development, growth hormone receptor signaling, ERK/MAPK and PI3K signaling). The mix suggests a module of signal transduction that coordinates immune responses with developmental processes, rather than a single isolated pathway.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0070374","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0000186","count":2}]},{"hash":"1456683527867782831","title":"Unknown","description":"Top GO terms span sensory perception (pain, thermoception, mechanical stimulus), calcium signaling, protein ubiquitination, oligodendrocyte differentiation, and NOD1 signaling, indicating a highly heterogeneous set with no single unifying function. There isn\u2019t a clear, representative theme to name this cluster, so Unknown is appropriate.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051209","count":1},{"id":"GO:1904908","count":1},{"id":"GO:0050968","count":1},{"id":"GO:0048709","count":1},{"id":"GO:0009409","count":1}]},{"hash":"2053260084058130718","title":"Neuronal Synaptic Plasticity and Junction Regulation","description":"The cluster centers on neural synaptic regulation and plasticity (positive regulation of excitatory postsynaptic potential, long-term synaptic depression, synapse structural plasticity) and includes social/grooming behavior terms, along with cell-cell adhesion processes (adherens and tight junction assembly) and cytoskeletal signaling (Rho, JNK), suggesting a module coordinating neural connectivity and behavior with junctional dynamics.","confidence":"Medium","size":10,"edges":43,"triangles":105,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2000463","count":6},{"id":"GO:0051660","count":6},{"id":"GO:0046328","count":6},{"id":"GO:0051835","count":6},{"id":"GO:0060292","count":6}]},{"hash":"757373678161891127","title":"Melanosome Transport and Hair Follicle Morphogenesis","description":"This cluster centers on pigment biology and skin/hair development, highlighted by melanosome transport and hair follicle morphogenesis. Supporting vesicle trafficking and membrane localization terms (Golgi docking, protein localization to plasma membrane) align with pigment cell function in delivering melanosomes. Additional terms about mitochondrial organization and gene regulation appear ancillary but compatible with cellular remodeling in hair follicle contexts.","confidence":"High","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010629","count":10},{"id":"GO:0001667","count":10},{"id":"GO:0045859","count":10},{"id":"GO:0000186","count":10},{"id":"GO:1903078","count":10}]},{"hash":"1130856740269580057","title":"Mitochondrial import and membrane regulation","description":"The strongest shared terms are protein import into the mitochondrial matrix and regulation of mitochondrial membrane permeability, which point to mitochondrial functions. Other terms point to signaling and development, suggesting a broader, mixed functional set, but the mitochondrial-related terms give this cluster a plausible core theme centered on mitochondrial handling and membrane dynamics. Confidence: Low","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0006400","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0007173","count":2},{"id":"GO:0046902","count":1}]},{"hash":"1299124173755821669","title":"Neural and sensory organ development","description":"The terms cluster around embryonic development of nervous system- and sensory-related tissues (forebrain, neural crest migration, cochlea/inner ear morphogenesis, motor neuron guidance) plus related structures (cartilage, muscle), suggesting a cohesive theme of neural/sensory organ formation, with a minor supportive regulatory term. This supports a broad developmental label rather than a single precise function.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902083","count":3},{"id":"GO:0051216","count":3},{"id":"GO:0001755","count":3},{"id":"GO:0090103","count":3},{"id":"GO:0021846","count":3}]},{"hash":"266404760052421579","title":"Cell migration and vascular remodeling regulation","description":"The cluster centers on cell movement and tissue remodeling, with GO terms dominated by cell migration and GTPase activation, plus several entries on developmental morphogenesis, vascular permeability/remodeling, and extravasation, along with negative regulation of immune and vascular processes. This suggests a cohesive theme of coordinated regulation of cell motility and vascular/immune dynamics, hence \"Cell migration and vascular remodeling regulation.\"","confidence":"Medium","size":10,"edges":40,"triangles":86,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0016477","count":4},{"id":"GO:0090630","count":4},{"id":"GO:0007480","count":3},{"id":"GO:0043314","count":3},{"id":"GO:0060268","count":3}]},{"hash":"1835201033451388011","title":"Immune and inflammatory response regulation","description":"Based on the prominence of acute-phase response, positive regulation of leukocyte tethering/rolling, and negative regulation of chemokine production, the cluster appears driven by immune/inflammatory signaling and modulation of leukocyte trafficking. Some developmental and transcription regulation terms are present but seem secondary and do not define a single cohesive pathway; the dominant theme is immune/inflammatory response regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006953","count":3},{"id":"GO:0045944","count":2},{"id":"GO:0031017","count":2},{"id":"GO:1903238","count":2},{"id":"GO:0051919","count":2}]},{"hash":"2045134839631311409","title":"Drosophila pole cell formation and axis patterning","description":"The top GO terms point to pole cell formation, maternal DV axis specification during oogenesis, and regulation of ecdysteroid biosynthesis, all linked to early germline development and embryonic patterning in Drosophila. This suggests a coherent theme around germ cell formation and axis specification in fruit flies.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007279","count":1},{"id":"GO:0007311","count":1},{"id":"GO:0045998","count":1}]},{"hash":"927449669286449348","title":"RNA and protein methylation processes","description":"The top GO terms are dominated by various methylation activities (rRNA, tRNA, arginine/glutamine methylation, and histone methylation), indicating a cluster centered on methyltransferase activity and methylation of RNA, proteins, and chromatin; a few unrelated terms exist but do not define the core function.","confidence":"High","size":10,"edges":28,"triangles":34,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046690","count":5},{"id":"GO:0031167","count":5},{"id":"GO:0019919","count":5},{"id":"GO:0043985","count":4},{"id":"GO:0018364","count":4}]},{"hash":"2238743353607497072","title":"GABAergic inhibitory synapses with neuromodulator regulation","description":"The terms cluster around GABA signaling and inhibitory synapses (IPSP, GABA pathway, receptor clustering, postsynaptic membrane organization, inhibition of action potentials) plus related neuromodulatory processes (dopaminergic, cholinergic signaling, norepinephrine secretion, nicotine response). This suggests a cohesive theme of GABAergic inhibition with broader neuromodulatory regulation at synapses.","confidence":"High","size":10,"edges":16,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060080","count":1},{"id":"GO:1901214","count":1},{"id":"GO:0032226","count":1},{"id":"GO:0001941","count":1},{"id":"GO:0007214","count":1}]},{"hash":"4729422221551644","title":"Developmental growth and cell adhesion","description":"This cluster centers on growth-related processes and tissue remodeling, highlighted by GO terms for cell growth, tissue regeneration, cell adhesion, and positive regulation of cell-matrix adhesion, as well as larval cuticle development; together they suggest a role in development and extracellular interactions, with supporting roles from vacuolar transport/acidification linked to cellular remodeling.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016049","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0000032","count":1},{"id":"GO:0008363","count":1}]},{"hash":"121656791037152810","title":"Cell differentiation and signaling","description":"This cluster centers on diverse differentiation programs (fat cell and cerebellar granule cell differentiation) and core regulatory/signaling processes (intracellular signal transduction, cell cycle regulation, telomere maintenance, and mRNA processing), suggesting a broad theme of differentiation plus signal-based regulation rather than a single specific pathway.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035994","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0045444","count":4},{"id":"GO:2001275","count":4},{"id":"GO:0016477","count":4}]},{"hash":"1495424642844513342","title":"GPCR-mediated cGMP and cAMP signaling","description":"The top terms point to GPCR-driven signaling pathways (adenosine receptor signaling, adrenergic receptor signaling) and cyclic nucleotide messengers (cGMP biosynthesis and receptor guanylyl cyclase signaling), along with forskolin-induced cAMP pathway activity and general intracellular signal transduction. This suggests a coherent cluster centered on membrane receptor signaling triggering second messenger cascades, with a minor peripheral link to protein anchoring processes. ","confidence":"High","size":10,"edges":28,"triangles":40,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006506","count":3},{"id":"GO:0030828","count":3},{"id":"GO:0071880","count":3},{"id":"GO:0035556","count":3},{"id":"GO:0006182","count":3}]},{"hash":"1780327741769395302","title":"Developmental morphogenesis and signaling regulation","description":"The cluster centers on developmental processes (cuticle development, body morphogenesis, embryo implantation, kidney development, spermatogenesis) and on modulation of signaling pathways (negative regulation of activin and BMP signaling) and associated cytoskeletal/receptor dynamics (receptor clustering, stress fiber assembly). This suggests proteins that coordinate tissue formation and signaling control across diverse contexts, rather than a single tissue-specific function.","confidence":"Medium","size":10,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008363","count":3},{"id":"GO:0010171","count":1},{"id":"GO:0040003","count":1},{"id":"GO:0032926","count":1},{"id":"GO:0051497","count":1}]},{"hash":"936948122680314582","title":"Neural development and neuromuscular regulation","description":"This cluster shows enrichment for brain development, neurofilament cytoskeleton organization, and neuromuscular process controlling posture, indicating a core theme of neural development and motor control. Some lipid/sterol metabolism and hormone biosynthesis terms are present, which may reflect secondary or multifunctional roles of the proteins, but they do not define the primary function of the cluster.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":2},{"id":"GO:0060052","count":2},{"id":"GO:0050884","count":2},{"id":"GO:0006671","count":1},{"id":"GO:2000182","count":1}]},{"hash":"1282339687224965758","title":"Embryonic and Neural Development with BMP Regulation","description":"This cluster combines GO terms across multiple developmental contexts (trophoblast differentiation, male gonad development, cerebellar cortex morphogenesis, neuron migration, eye development) and includes regulation of signaling pathways (BMP signaling, tyrosine phosphorylation) and apoptosis. The common thread is broad developmental differentiation and signaling control prevalent in embryonic and neural tissues, with BMP pathway regulation serving as a unifying mechanism.","confidence":"Medium","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060718","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0045671","count":4},{"id":"GO:0030514","count":4},{"id":"GO:0050732","count":4}]},{"hash":"2198704983261228163","title":"Chondrogenesis and bone remodeling","description":"This cluster centers on chondrocyte differentiation/proliferation and integrin-mediated adhesion, with involvement in regulation of bone resorption, pointing to cartilage formation and skeletal remodeling; accompanying terms about vascular and organ development suggest a broader mesenchymal developmental context.","confidence":"Medium","size":10,"edges":13,"triangles":5,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0033627","count":2},{"id":"GO:0001558","count":2},{"id":"GO:0035988","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0045599","count":2}]},{"hash":"787034653190182370","title":"Neural Development and Tissue Morphogenesis","description":"This cluster is dominated by GO terms highlighting morphogenesis of neural and sensory structures (cochlea and cerebellum) and neural tube development, plus signaling and cell-junction processes (TGF-beta response, planar polarity, tight junction assembly) that coordinate tissue organization. The combination suggests a cohesive theme of neural development and broader tissue morphogenesis.","confidence":"High","size":9,"edges":30,"triangles":50,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071560","count":4},{"id":"GO:0090179","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0016310","count":3},{"id":"GO:0090103","count":3}]},{"hash":"1589541392368049083","title":"Cerebellar neuron development and maturation","description":"The top GO terms cluster around cerebellar development and neuron differentiation, including granule cell precursor proliferation, Purkinje cell layer maturation, and radial glia\u2013guided migration, plus branching morphogenesis of neurons. While some terms are generic (DNA-templated transcription, chromatin remodeling), the collective signal points to cerebellar neuron development and maturation as the core theme.","confidence":"Medium","size":9,"edges":14,"triangles":4,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0021930","count":2},{"id":"GO:0070933","count":2},{"id":"GO:0031937","count":2},{"id":"GO:0048755","count":2}]},{"hash":"1354997164899320839","title":"Ribosome Biogenesis and Translation Regulation","description":"The dominant signal is translation and ribosome-associated RNA processing: GO:0006412 (translation) and GO:0000462 (maturation of SSU-rRNA) point to ribosome assembly and function. Additional RNA processing terms (RNA folding, intron splicing, positive regulation of RNA splicing) further support a broader RNA maturation theme linked to gene expression. Some proteostasis and antibiotic-response terms may reflect stress responses related to translation. Overall, this cluster centers on ribosome biogenesis and translation with related RNA processing activities.","confidence":"High","size":9,"edges":22,"triangles":23,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0000462","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0034337","count":2},{"id":"GO:0006450","count":2}]},{"hash":"1255838605021980105","title":"Centromeric chromatin assembly and replication","description":"Based on GO terms dominated by centromere-associated chromatin (CENP-A assembly), histone modification, and Okazaki-fragment processing during mitosis, the cluster appears to group proteins involved in chromatin maintenance and DNA replication fidelity at the centromere. Additional signals for chromosome segregation and ubiquitination regulation reinforce this theme. Some inflammatory and developmental terms may reflect broader roles of these proteins, but the core connection favors chromatin-centric cell cycle functions.","confidence":"High","size":9,"edges":9,"triangles":1,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:1903461","count":4},{"id":"GO:0045143","count":4},{"id":"GO:0051567","count":4},{"id":"GO:1902525","count":4},{"id":"GO:0002534","count":4}]},{"hash":"1601107690042291246","title":"Developmental gene expression and morphogenesis","description":"Top GO terms converge on developmental processes and transcriptional regulation, including forebrain development, neural tube closure, skeletal system development, and multicellular organism development, along with DNA-templated transcription. This points to a cluster of proteins involved in developmental regulation and gene expression control, with some terms hinting at broader signaling or stress responses but the dominant theme remains developmental transcriptional activity.","confidence":"High","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006349","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0030900","count":2}]},{"hash":"1233657471530882872","title":"Plant DNA Repair and Chromatin Remodeling in Meristems","description":"Top GO terms center on DNA repair and chromatin organization, with plant developmental terms for root/vegetative meristem growth and trichome differentiation, suggesting a theme of DNA repair and chromatin remodeling in plant meristem development.","confidence":"Medium","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006284","count":2},{"id":"GO:0006289","count":2},{"id":"GO:0010449","count":1},{"id":"GO:0010448","count":1},{"id":"GO:0010026","count":1}]},{"hash":"937558431116150287","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":18,"triangles":11,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071039","count":2},{"id":"GO:0070478","count":2},{"id":"GO:0071028","count":2},{"id":"GO:0071035","count":2},{"id":"GO:0008033","count":2}]},{"hash":"1586726586995387420","title":"Actin cytoskeleton remodeling and signaling","description":"The cluster shows multiple GO terms tied to actin cytoskeleton organization and filopodium assembly, plus a mix of signaling and developmental terms such as insulin receptor signaling and tubule morphogenesis. This pattern suggests proteins involved in dynamic cytoskeletal remodeling that also participate in broader signaling pathways, though the presence of several unrelated terms lowers cohesion.","confidence":"Medium","size":9,"edges":34,"triangles":71,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0009638","count":2}]},{"hash":"722418569989878129","title":"Ribosome biogenesis and translation","description":"The dominant terms are about translation, maturation of SSU-rRNA, and ribosome biogenesis/assembly, indicating these proteins cluster around ribosome production and protein synthesis; a few related terms about transcription termination and regulation of translation support but do not override the core ribosome-focused theme.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0031564","count":2},{"id":"GO:0006353","count":2}]},{"hash":"1481576604731784529","title":"Developmental signaling and cytoskeletal dynamics","description":"The Top Terms point to neuronal signaling (positive regulation of excitatory postsynaptic potential) alongside processes of cell movement, division, and development (cleavage furrow formation, substrate-dependent cell migration, hard palate and adipose tissue development). This suggests a set of proteins involved in broader developmental regulation and structural/cytoskeletal organization rather than a single, tightly defined pathway. Some terms are obsolete, indicating possible dataset noise, but the overall theme centers on development with dynamic cell architecture. ","confidence":"Medium","size":9,"edges":33,"triangles":66,"max_degree":8,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2000463","count":4},{"id":"GO:1900740","count":4},{"id":"GO:0033578","count":4},{"id":"GO:0006348","count":4},{"id":"GO:1904179","count":4}]},{"hash":"1451444259800596354","title":"Dopaminergic signaling and transcription regulation","description":"The cluster centers on dopaminergic synaptic signaling and transcriptional control, with multiple terms linking positive regulation of dopaminergic transmission and RNA polymerase II\u2013mediated transcription, plus ERK/MAPK cascade regulation, receptor internalization, and proteasome-dependent protein turnover. This suggests a coherent module where dopamine signaling interacts with transcriptional programs and protein turnover in cells, likely neurons. ","confidence":"Medium","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060765","count":5},{"id":"GO:0032226","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0090240","count":4},{"id":"GO:0031651","count":4}]},{"hash":"2042091266827786249","title":"Synaptic Signaling and Ion Transport","description":"The top GO terms point to signaling at membranes and Ion flux with neural and cardiac relevance: receptor localization to synapse and GABA secretion indicate neurotransmission; membrane depolarization in atrial cardiac muscle cells reflects electrophysiology; regulation of potassium ion import and phosphorylation relate to ion homeostasis and signaling modulation. Some terms also touch on cell polarity and centrosome localization, but the main theme is membrane-associated signaling and ion dynamics across neural and cardiac contexts.","confidence":"Medium","size":9,"edges":33,"triangles":65,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":8},{"id":"GO:0098912","count":7},{"id":"GO:0097120","count":7},{"id":"GO:0045197","count":7},{"id":"GO:1903286","count":7}]},{"hash":"466074799707454248","title":"Actin-driven cell migration and adhesion","description":"The cluster is dominated by actin cytoskeleton remodeling and protrusion-related terms (filopodium assembly, actin filament branching, cell shape/polarity) and processes tied to cell spreading and fibroblast migration, indicating a cohesive theme of actin-driven motility and adhesion. While signaling terms like T cell receptor and Wnt appear, the core representation centers on actin dynamics and movement.","confidence":"High","size":9,"edges":10,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043552","count":3},{"id":"GO:0046847","count":3},{"id":"GO:0090135","count":3},{"id":"GO:0031532","count":3},{"id":"GO:1900026","count":3}]},{"hash":"2054764094237483097","title":"Inflammatory mediator production and chemokine regulation","description":"This cluster is dominated by GO terms related to inflammatory signaling, notably production of inflammatory mediators and positive regulation of chemokine production, suggesting an immune/inflammatory role. While there are peripheral terms about carbohydrate and other catabolic processes, these are much less represented and likely incidental. Overall, the immune/inflammatory theme best represents the cluster, with moderate confidence due to some conflicting or ancillary terms.","confidence":"Medium","size":9,"edges":5,"triangles":0,"max_degree":5,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002532","count":7},{"id":"GO:0005975","count":7},{"id":"GO:0090197","count":7},{"id":"GO:0006032","count":7},{"id":"GO:0051573","count":1}]},{"hash":"203439285676607710","title":"Unknown","description":"The terms are highly heterogeneous\u2014thiamine biosynthesis, LPS and fungicide responses, cAMP signaling, dopamine catabolic processes, and development\u2014without a single, cohesive biological theme linking the proteins.","confidence":"","size":9,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0071320","count":5},{"id":"GO:0032496","count":5},{"id":"GO:0009228","count":5},{"id":"GO:0051573","count":4}]},{"hash":"1801775483836673833","title":"Unknown","description":"The terms cover a mix of developmental processes (mesoderm development, EMT, connective tissue remodeling), meiotic and DNA repair activities, and neural signaling/drug response (excitatory postsynaptic potential, response to cocaine) along with regulatory processes like miRNA processing and glucose signaling. There isn\u2019t a single cohesive function tying all these together, so a concise, representative label isn\u2019t evident.","confidence":"","size":9,"edges":25,"triangles":38,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007498","count":7},{"id":"GO:1905205","count":7},{"id":"GO:0072462","count":7},{"id":"GO:0051321","count":7},{"id":"GO:0042220","count":7}]},{"hash":"378442505834679626","title":"Mitochondrial metabolism and tRNA wobble modification","description":"The top terms highlight mitochondrial metabolism\u2014such as acetyl-CoA biosynthesis from pyruvate and anaerobic respiration\u2014and a specific mitochondrial tRNA wobble uridine modification, suggesting the cluster centers on mitochondrial energy metabolism and RNA modification. Other terms are sparse or broader and may reflect miscellaneous annotations, but the mitochondria-focused functions provide the clearest shared theme. ","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0051573","count":1},{"id":"GO:0061732","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0009061","count":1}]},{"hash":"21982932680382958","title":"Mitochondrial dynamics and distribution","description":"This cluster is dominated by mitochondrial-related terms: membrane organization, fission, inheritance, and intracellular distribution of mitochondria, suggesting a core function in mitochondrial dynamics and positioning. The additional terms for vacuole targeting and endocytic recycling point to broader organelle trafficking connections, while heart contraction, GABAergic synaptic transmission, and ephrin signaling reflect roles of mitochondria in energy-demanding tissues and signaling contexts. Taken together, the proteins likely participate in mitochondrial dynamics and their intracellular distribution, with related trafficking and signaling links.","confidence":"High","size":9,"edges":13,"triangles":7,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007006","count":8},{"id":"GO:0006623","count":8},{"id":"GO:0032456","count":8},{"id":"GO:0060047","count":8},{"id":"GO:0000266","count":8}]},{"hash":"1373354127302761341","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":8,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006450","count":2},{"id":"GO:0070143","count":2},{"id":"GO:0006435","count":2},{"id":"GO:0099132","count":1},{"id":"GO:0042777","count":1}]},{"hash":"1262892235171183665","title":"Immune Response and Inflammatory Regulation","description":"The terms cluster around immune signaling and responses to external stimuli (xenobiotic stimuli, lipopolysaccharide, GM-CSF, and interferon production) with related regulatory effects on vascular permeability and cardiac muscle relaxation. A few terms touch on development (neuron maturation, oocyte development) but the dominant pattern is immune/inflammatory regulation. ","confidence":"Medium","size":9,"edges":18,"triangles":14,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035690","count":6},{"id":"GO:0071222","count":5},{"id":"GO:0014041","count":4},{"id":"GO:0097011","count":4},{"id":"GO:0050995","count":4}]},{"hash":"388459886251013811","title":"Cytoskeleton remodeling and membrane trafficking","description":"Label reflects enrichment for actin-driven protrusions and trafficking: filopodium assembly and its regulation, endocytic recycling, and small GTPase\u2013mediated signaling that controls adhesion and receptor pathways (ephrin signaling). Mitochondrial organization and inheritance appear secondary, possibly due to multifunctional proteins, but the dominant theme is cytoskeleton dynamics and vesicular transport. Overall, the cluster links proteins involved in cytoskeleton remodeling and membrane trafficking.","confidence":"Medium","size":9,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007006","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0006623","count":2},{"id":"GO:0007264","count":2}]},{"hash":"982317683683444683","title":"Immune signaling and phagocytosis regulators","description":"The cluster is dominated by GO terms tied to immune cell function and vesicle-related processes, including positive regulation of phagocytosis, dendritic cell chemotaxis, and non-canonical NF-kappaB signaling, suggesting roles in immune activation and phagocytic regulation. Additional terms like synaptic vesicle endocytosis and cell spreading point to vesicle trafficking and cytoskeletal dynamics that often accompany immune cell responses. While there are outlier terms such as sperm binding and general protein folding that may reflect broader functional pleiotropy, the core theme centers on immune signaling and phagocytic regulation. Taken together, the label reflects the strongest, cohesive signals in the cluster, with some noise from unrelated processes.","confidence":"Medium","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":"protein folding","top_go_terms":[{"id":"GO:0006457","count":4},{"id":"GO:0050766","count":4},{"id":"GO:0007339","count":4},{"id":"GO:0048488","count":4},{"id":"GO:0071157","count":4}]},{"hash":"1393460068966490011","title":"Embryonic organ and tissue development","description":"This cluster is dominated by GO terms related to the development of various organs (heart, retina, kidney) and tissue formation, suggesting a general theme of embryonic organogenesis. Some terms touch on cell signaling and proliferation, which can accompany developmental processes, but the core signal points to multi-organ development during embryogenesis.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":8},{"id":"GO:0007601","count":8},{"id":"GO:0010842","count":7},{"id":"GO:1905205","count":7},{"id":"GO:0090151","count":7}]},{"hash":"507507193107175144","title":"Immune, metabolic, and vascular signaling regulation","description":"The cluster shows enrichment for insulin receptor signaling and T cell receptor signaling (immune/metabolic signaling), ER stress and unfolded protein response regulation (stress signaling), and vascular/endothelial barrier/permeability terms, plus p38 MAPK regulation and neuronal dendritic development terms. This pattern points to a group of proteins that modulate various signaling pathways across immune, metabolic, and vascular stress contexts, rather than a single tight function. ","confidence":"Medium","size":9,"edges":32,"triangles":62,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1903898","count":8},{"id":"GO:0050852","count":8},{"id":"GO:2001275","count":8},{"id":"GO:0008286","count":8},{"id":"GO:1902237","count":8}]},{"hash":"899668049827545116","title":"Unknown","description":"The terms span aromatic amino acid metabolism, cytoplasmic translational elongation, cyclooxygenase signaling, redox-related glutathionylation, starvation response, and immune signaling; there is no single cohesive function linking them, suggesting the cluster does not correspond to a well-defined, common biological process.","confidence":"","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009072","count":1},{"id":"GO:0002182","count":1},{"id":"GO:0019371","count":1},{"id":"GO:1905804","count":1},{"id":"GO:0042594","count":1}]},{"hash":"1331924642757207737","title":"Olfaction and Social Behavior","description":"The top GO terms center on sensory perception of smell, pheromone response, social behavior, and related circadian sleep aspects, pointing to a theme of olfactory-driven and socially modulated behaviors. A few terms relate to unrelated developmental processes (bone mineralization, embryo implantation, VEGF signaling), suggesting mixed functions in the cluster, but the dominant signal is behavioral and sensory in nature.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042595","count":1},{"id":"GO:0019236","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0035176","count":1}]},{"hash":"514041252233253565","title":"Mitochondrial Transport and Metabolic Regulation","description":"Based on the GO terms, most functions center on transport across mitochondrial membranes (CoA, L-ornithine, deoxynucleotides, magnesium export) and regulation of mitochondrial permeability, with supportive links to insulin/IGF signaling and liver regeneration. This suggests a cohesive cluster of mitochondrial transporters and metabolic regulators.","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046902","count":2},{"id":"GO:0097274","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0035349","count":2},{"id":"GO:0000066","count":2}]},{"hash":"2150779657618790646","title":"Unknown","description":"The terms are highly heterogeneous, spanning several distinct catabolic pathways (aromatic compounds, propylene, tryptophan), halogen metabolism, ferrichrome biosynthesis, and multiple general stress responses (cold, xenobiotic, aluminum ion), with one outlier term about pituitary gland development. This lack of a unifying function or pathway makes it impossible to assign a specific, representative label with confidence.","confidence":"","size":9,"edges":9,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019622","count":1},{"id":"GO:0042208","count":1},{"id":"GO:0070276","count":1},{"id":"GO:0021983","count":1},{"id":"GO:0009409","count":1}]},{"hash":"798342424013519929","title":"T Cell Activation and LPS Signaling","description":"This cluster centers on immune activation with GO terms for T cell cytokine production and proliferation, immunoglobulin production, and lipopolysaccharide signaling, plus regulation of NF-kappaB and JUN kinase pathways, indicating coordinated adaptive and innate immune responses.","confidence":"High","size":9,"edges":29,"triangles":45,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045084","count":2},{"id":"GO:0002726","count":2},{"id":"GO:2001238","count":2},{"id":"GO:0043507","count":2},{"id":"GO:0051023","count":2}]},{"hash":"1428631780271729253","title":"Unknown","description":"The terms span immune signaling (defense response to Gram-positive bacterium, NF-kappaB regulation, leukocyte tethering) and various development and metabolic processes (pharynx/exocrine pancreas development, cuticle development, proteoglycan biosynthesis, GDP/UDP catabolism) with no clear unifying function or network connectivity, so a cohesive label cannot be assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":2},{"id":"GO:0008363","count":1},{"id":"GO:0030166","count":1},{"id":"GO:0046712","count":1},{"id":"GO:0006256","count":1}]},{"hash":"585054596082466960","title":"AV Node Action Potentials and Cardiac Conduction","description":"These proteins show a clear focus on cardiac electrical activity, especially AV node\u2013related processes: AV node action potential, membrane depolarization, and regulation of heart rate by cardiac conduction, along with calcium release that drives excitation\u2013contraction. A few terms touch broader regulatory pathways, but the dominant theme is AV node electrophysiology and heart conduction.","confidence":"High","size":9,"edges":12,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048016","count":2},{"id":"GO:0086016","count":2},{"id":"GO:0008627","count":2},{"id":"GO:1902303","count":2},{"id":"GO:0086091","count":2}]},{"hash":"1282825025551146843","title":"Cholesterol and Lipoprotein Metabolism with Hedgehog Signaling","description":"This cluster is dominated by lipid metabolism terms: triglyceride biosynthesis, cholesterol storage, cholesterol homeostasis, lipoprotein particle levels, and VLDL assembly, with cholesterol efflux as another related process. The presence of the smoothened signaling pathway and lipid modifications (N-palmitoylation, peptidyl-serine octanoylation) suggests lipid-mediated signaling, notably Hedgehog signaling that relies on cholesterol-related modification for SMO activity. The link to APP biosynthesis regulation hints at membrane-cholesterol context influencing APP processing. Together, these terms point to a cohesive theme of lipid handling and Hedgehog signaling.","confidence":"High","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0019432","count":6},{"id":"GO:0010878","count":4},{"id":"GO:0042986","count":4},{"id":"GO:0007224","count":4},{"id":"GO:0018009","count":4}]},{"hash":"1862751954553936288","title":"Hypoxia-responsive transcription and vascular development","description":"The top terms point to transcriptional activity (DNA-templated transcription) plus hypoxia-related regulation (peptidyl hydroxylation terms tied to oxygen-sensing pathways and negative regulation of transcription in response to hypoxia), along with developmental processes such as vasculogenesis and myoblast differentiation. This pattern suggests a theme where hypoxia signaling modulates transcription and vascular/muscle development, hence a cohesive label around hypoxia-regulated transcription and vascular development.","confidence":"Medium","size":9,"edges":23,"triangles":26,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042265","count":2},{"id":"GO:0042264","count":2},{"id":"GO:0061428","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0045663","count":2}]},{"hash":"645509117720375155","title":"Chemokine-driven inflammation and leukocyte recruitment","description":"Most of the top terms point to inflammatory signaling and immune cell recruitment, including production of inflammatory mediators, regulation of chemokine production, and leukocyte tethering/rolling. A few terms reference development or cellular localization, but the dominant pattern is immune/ inflammatory processes, supporting a label focused on inflammation and immune cell recruitment.","confidence":"High","size":9,"edges":16,"triangles":13,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0002532","count":7},{"id":"GO:0005975","count":7},{"id":"GO:0090197","count":7},{"id":"GO:0006032","count":7},{"id":"GO:0048050","count":2}]},{"hash":"2244201568396460103","title":"Bacterial cell wall glycosylation and teichoic acid biosynthesis","description":"The top GO terms cluster around cell wall organization, teichoic acid biosynthesis, arabinan-containing polysaccharide metabolism, and O-linked glycosylation pathways, indicating a cohesive role in assembling and modifying bacterial cell wall glycans, particularly teichoic acids and related polysaccharides.","confidence":"High","size":9,"edges":23,"triangles":22,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":6},{"id":"GO:0018242","count":5},{"id":"GO:0031221","count":5},{"id":"GO:0006011","count":5},{"id":"GO:0019350","count":5}]},{"hash":"583260611484657129","title":"Organelle transport and ion homeostasis","description":"This cluster centers on vacuolar functions (vacuole organization, protein targeting to vacuole, vacuolar acidification) and ion handling (sodium and proton transport, proton motive force-driven ATP synthesis, copper ion homeostasis), pointing to coordinated organelle trafficking and maintenance of ion gradients; a few terms like chromatin organization appear as minor outliers.","confidence":"Medium","size":9,"edges":31,"triangles":56,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":3},{"id":"GO:0070584","count":2},{"id":"GO:0006878","count":2},{"id":"GO:0007033","count":2},{"id":"GO:0006623","count":2}]},{"hash":"33479146058647994","title":"Pheromone Detection","description":"The only annotated function is pheromone detection (GO:0043695) with a single hit, and there are no edges among the proteins, so the cluster may reflect a narrow pheromone-sensing role, but support is weak due to minimal annotation and lack of interactions.","confidence":"Low","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":1}]},{"hash":"858718762383051482","title":"GPCR-Linked Cardio-Neural Development and Synapse Maintenance","description":"The set of terms centers on GPCR signaling that activates adenylate cyclase, with strong links to cardiovascular development (blood pressure regulation, heart trabecula formation) and neural development (neuron migration, cortical layer formation) as well as synapse maintenance, indicating a module focused on GPCR-driven cardio-neural development and synaptic stability. An energy metabolism term (electron transport chain) is present but less central to the inferred theme. ","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":9},{"id":"GO:0045777","count":9},{"id":"GO:0022900","count":9},{"id":"GO:0007190","count":9},{"id":"GO:0060347","count":6}]},{"hash":"740771367319716118","title":"Gene expression and cell proliferation regulation","description":"This cluster is enriched for both transcription-related (DNA-templated transcription, mRNA processing, decapping) and cell-cycle/proliferation terms (mitotic spindle checkpoint signaling, various tissue proliferation/differentiation terms). The mix suggests a broad module coordinating gene expression with cell growth and division, rather than a single tissue-specific function. Therefore a label focusing on gene expression and cell proliferation regulation is most representative.","confidence":"Medium","size":8,"edges":17,"triangles":12,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0097350","count":3},{"id":"GO:0045819","count":3},{"id":"GO:0090090","count":3},{"id":"GO:0045654","count":3}]},{"hash":"278375438166542441","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1902775","count":4},{"id":"GO:0071031","count":4},{"id":"GO:0045944","count":4},{"id":"GO:0031124","count":4},{"id":"GO:0010501","count":4}]},{"hash":"1225088598815642357","title":"Ribosome biogenesis and SSU rRNA maturation","description":"The cluster is dominated by ribosome biogenesis terms, including ribosome biogenesis, small subunit biogenesis, and maturation of SSU-rRNA, indicating a core role in ribosome assembly and rRNA processing. While there are additional annotations for transcription, replication, and stress-related processes (UPR, viral process), these are less represented, so the main theme is ribosome biogenesis. ","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0016032","count":2}]},{"hash":"8196466086534756","title":"Motor and cerebellar neuron differentiation","description":"The top GO terms cluster around neuronal development and differentiation, notably motor column neuron differentiation, lateral/medial motor neuron migration, and Purkinje cell differentiation, suggesting a theme of neuronal lineage specification and maturation. Some terms appear unrelated (plant/immune pathways), likely noise, but the dominant signal supports neural differentiation.","confidence":"Medium","size":8,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097477","count":4},{"id":"GO:0097067","count":4},{"id":"GO:0045805","count":4},{"id":"GO:0021702","count":4},{"id":"GO:0021526","count":4}]},{"hash":"1906361038510771511","title":"RNA Processing and Ribosome Biogenesis Factors","description":"The top GO terms cluster around RNA metabolism and processing: alternative mRNA splicing via spliceosome, mRNA stabilization, and small-subunit processome assembly, all pointing to RNA maturation. There are also terms related to translation initiation factor complex assembly, suggesting a link to protein synthesis, though less central. Taken together, the dominant theme is RNA processing and ribosome biogenesis, with minor ties to translation initiation. ","confidence":"Medium","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000380","count":6},{"id":"GO:0048255","count":5},{"id":"GO:0034462","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0000381","count":5}]},{"hash":"997039441143229221","title":"Ubiquitin-mediated proteostasis and microtubule regulation","description":"The top GO terms cluster around ubiquitination processes (protein ubiquitination, positive regulation of ubiquitin-specific protease activity, SCF complex disassembly in stress) and cytoskeletal/cell cycle functions (cytoplasmic microtubule organization, mitotic sister chromatid separation, protein unfolding), suggesting a coherent theme of protein quality control and microtubule dynamics during mitosis. Some terms (rRNA decay, sterol metabolism, photoreceptor organization) are less central but may reflect broader cellular homeostasis or membrane/cargo dynamics linked to proteostasis and cell division.","confidence":"Medium","size":8,"edges":22,"triangles":26,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051306","count":3},{"id":"GO:0070651","count":3},{"id":"GO:0090502","count":2},{"id":"GO:0045470","count":2},{"id":"GO:0016125","count":2}]},{"hash":"2008208839109537323","title":"Organogenesis and lineage specification","description":"The cluster centers on developmental differentiation across many tissues (pancreas, lung, muscle, nervous system, retina) and cell fate decisions, with transcription by RNA polymerase II indicating broad regulatory programs that drive embryonic organogenesis rather than a single tissue function. ","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0031018","count":6},{"id":"GO:0060426","count":5},{"id":"GO:0060163","count":5},{"id":"GO:0001756","count":5}]},{"hash":"906804736466483675","title":"Developmental Signaling Across Nerve, Muscle, Immune","description":"This cluster mixes terms for nervous system development, skeletal muscle development and differentiation, and B cell receptor signaling, indicating a broader role in developmental signaling across tissues. Additional terms point to general signaling regulation (MAPK, PDGF) and cellular responses (calcium signaling, ubiquitin-mediated proteolysis), which are common in development and differentiation processes. Overall, the data support a theme of developmental signaling rather than a single pathway.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0035914","count":2}]},{"hash":"2098433579615578647","title":"Cell Division and Neuronal Differentiation","description":"The top GO terms cluster around cell cycle and mitosis (cell cycle, mitotic spindle pole body duplication, mitotic cytokinesis) and neuronal development (neuron migration, neuron differentiation), suggesting a theme of division-related processes with neural development, with some ancillary mechanosensory and signaling terms.","confidence":"Medium","size":8,"edges":12,"triangles":3,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0001764","count":3},{"id":"GO:1903087","count":3},{"id":"GO:0051258","count":3},{"id":"GO:1905789","count":3}]},{"hash":"1017778535794190644","title":"Unknown","description":"The top GO terms cover very different biological areas (prostaglandin biosynthesis, aromatic amino acid metabolism, translation elongation, stress responses, transcription factor sequestration, apoptosis regulation, redox-related glutathionylation, and homogentisate catabolism) with no single cohesive function tying the cluster together. Because the terms do not point to a unified biological process or pathway, a precise, representative label cannot be assigned.","confidence":"","size":8,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":4},{"id":"GO:0009072","count":2},{"id":"GO:0002182","count":2},{"id":"GO:0042594","count":2},{"id":"GO:0071638","count":2}]},{"hash":"1417775220296726544","title":"Cardiac muscle contraction and sarcomere organization","description":"The top GO terms cluster around cardiac biology: cardiac muscle contraction (GO:0007049), sarcomere organization (GO:0045214) and regulation of heart rate by epinephrine (GO:0003065), plus positive regulation of sarcomere organization (GO:0060298). There are also related vascular smooth muscle regulation terms (GO:1904706, GO:1904753). A few terms such as neuron migration and spindle pole duplication are present but not central. Overall, the cluster appears to reflect cardiac muscle structure and function, particularly contraction and sarcomere organization.","confidence":"Medium","size":8,"edges":17,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0034609","count":2},{"id":"GO:0003065","count":2},{"id":"GO:0060298","count":2},{"id":"GO:1904706","count":2},{"id":"GO:0060048","count":2}]},{"hash":"871739530160494719","title":"Deubiquitinase-regulated inflammatory signaling","description":"The GO terms cluster around various ubiquitin-related processes (K27-, K11-, K48-, K6-linked deubiquitination and ubiquitination) together with immune signaling regulation (negative regulation of chronic inflammatory response, CD40 signaling, IL-2 production) and response to muramyl dipeptide. This suggests a cohesive theme of ubiquitin-mediated control of innate immune and inflammatory pathways, rather than unrelated functions. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032495","count":2},{"id":"GO:0031532","count":2},{"id":"GO:1990167","count":1},{"id":"GO:0035871","count":1},{"id":"GO:2000349","count":1}]},{"hash":"1733238470398169271","title":"Bacterial translation and cell division","description":"This cluster is enriched for translation-related processes (cytoplasmic translation, ribosomal small subunit biogenesis, and tRNA modification) and cell division/septum assembly, suggesting a cohesive theme around protein synthesis machinery linked to bacterial cytokinesis, with some transport terms as ancillary functions.","confidence":"High","size":8,"edges":16,"triangles":12,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":2},{"id":"GO:0007049","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0042274","count":1},{"id":"GO:0015684","count":1}]},{"hash":"488465751448072996","title":"Insect melanization and hemolymph coagulation immune response","description":"The cluster centers on melanin biosynthesis from tyrosine, melanotic encapsulation, scab formation, and hemolymph coagulation, all pointing to an insect immune defense mechanism driven by melanization. Additional terms about regulation of melanization support this cohesive immune-related theme, despite a few obsolete or unrelated terms.","confidence":"Medium","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042381","count":2},{"id":"GO:0006583","count":2},{"id":"GO:0035314","count":2},{"id":"GO:0035011","count":2}]},{"hash":"1080185979615106483","title":"Nucleocytoplasmic Transport & Ribophagy","description":"The top GO terms cluster around transport between the nucleus and cytoplasm (protein import/export, nuclear pore localization, mRNA export) and broader vesicle trafficking, with an additional note on ribophagy. This suggests a cohesive theme of nucleocytoplasmic trafficking, sometimes linked to ribosome turnover pathways, rather than a single straightforward pathway. ","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071806","count":2},{"id":"GO:2000156","count":2},{"id":"GO:1904046","count":2},{"id":"GO:0042307","count":2},{"id":"GO:0000060","count":2}]},{"hash":"924334407829378694","title":"Unknown","description":"The eight proteins show a mix of GO terms spanning pheromone detection, fibrinolysis regulation, insulin processing, liver regeneration, Purkinje cell differentiation, heat response, and protein deglutamylation, with no clear shared pathway or function, suggesting no cohesive theme in this cluster.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":3},{"id":"GO:0051918","count":1},{"id":"GO:0021702","count":1},{"id":"GO:0030070","count":1},{"id":"GO:0009408","count":1}]},{"hash":"1584592801800134946","title":"AV node electrophysiology and cardiac conduction","description":"Based on the strongest GO terms in the cluster, especially AV node cell action potential, membrane depolarization during AV node action potential, and regulation of heart rate by cardiac conduction, this cluster appears focused on AV node electrophysiology and heart rhythm control. Other terms (hypoxia, apoptosis) are present but not central to the core theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097050","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0045429","count":1},{"id":"GO:0001822","count":1},{"id":"GO:0048016","count":1}]},{"hash":"2118327448695634759","title":"Diverse metabolite catabolism","description":"The cluster\u2019s top GO terms are predominantly catabolic or metabolic across a broad range of substrates (lipids like triglycerides; nucleotides like uracil; glucuronides; alkaloids; xenobiotics such as 1,2-dichloroethane), with a few related regulatory or detox-related terms (endocannabinoid signaling regulation, response to toxic substances). This points to a general theme of metabolism and breakdown of diverse compounds rather than a single pathway, so a concise label like Diverse metabolite catabolism fits best. Some terms are peripheral or regulatory, but the core pattern is broad metabolic catabolism.","confidence":"Medium","size":8,"edges":18,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":5},{"id":"GO:0097755","count":4},{"id":"GO:2000124","count":4},{"id":"GO:0019260","count":4},{"id":"GO:0042619","count":4}]},{"hash":"1886819517040832079","title":"Glucose and sugar transport","description":"The cluster shows multiple GO terms tied to transmembrane transport of sugars and related solutes (D-glucose and D-xylose transmembrane transport, glucose transport with insulin stimulus, sodium-dependent organic cation transport, and selenite transport), plus regulatory contexts like glucose starvation and osmotic stress. This points to a cohesive theme of membrane-mediated sugar uptake and handling. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010043","count":2},{"id":"GO:0060731","count":1},{"id":"GO:0006970","count":1},{"id":"GO:0097080","count":1},{"id":"GO:0070715","count":1}]},{"hash":"437438135586998715","title":"Collagen maturation and ECM assembly","description":"The dominant GO terms center on collagen fibril organization and prolyl hydroxylation of proline, both hallmarks of collagen synthesis and extracellular matrix formation. Prolyl hydroxylation is a key post-translational modification for collagen stability and requires oxygen, which aligns with intracellular oxygen homeostasis. Some terms are obsolete or peripheral, but the core theme clearly points to collagen processing and ECM assembly.","confidence":"Medium","size":8,"edges":6,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0032364","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0032504","count":1}]},{"hash":"1647889035904272631","title":"Meiosis and DNA Repair","description":"The top GO terms are dominated by meiotic processes (meiotic recombination checkpoint signaling, meiotic cell cycle) and a specific DNA repair pathway (DNA double-strand break processing involved in repair via synthesis-dependent strand annealing), pointing to meiosis-associated DNA repair as the core function of this cluster. Other terms like mesoderm development and epithelial to mesenchymal transition suggest broader developmental regulation and signaling roles but do not outweigh the meiosis/DNA repair signal. Confidence in this label is Medium.","confidence":"Medium","size":8,"edges":13,"triangles":8,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":2},{"id":"GO:0007498","count":2},{"id":"GO:1905205","count":2},{"id":"GO:0072462","count":2},{"id":"GO:0051321","count":2}]},{"hash":"234912169494259179","title":"Face Morphogenesis","description":"This cluster is enriched for face morphogenesis (GO:0060325), with 4 of 8 proteins linked to facial development, suggesting a developmental, structural role in shaping facial features.","confidence":"High","size":8,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":4}]},{"hash":"139214741980794723","title":"ER Unfolded Protein Response","description":"Based on the top GO term, these proteins are linked to the endoplasmic reticulum unfolded protein response, indicating involvement in ER stress and protein quality control; despite lack of internal edges, the GO annotation suggests a coherent functional theme for the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030968","count":1}]},{"hash":"536665562536730088","title":"Unknown","description":"The terms are highly diverse, spanning immune/lytic processes (cytolysis, defense response to bacterium), ion transport and pH/osmotic regulation (sodium ion homeostasis, sodium ion transmembrane transport, response to acidic pH, cellular response to pH, water homeostasis), and mechanosensation/synaptic regulation. There isn\u2019t a single cohesive function or pathway tying these proteins together, so a specific, representative label cannot be assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019835","count":1},{"id":"GO:0042742","count":1},{"id":"GO:0060025","count":1},{"id":"GO:0055078","count":1},{"id":"GO:0010447","count":1}]},{"hash":"2146851434078951632","title":"Nuclear RNA Processing and Surveillance","description":"This cluster is characterized by GO terms tied to nuclear RNA maturation and decay (rRNA, snoRNA, CUTs), mRNA surveillance, and RNA-directed silencing, indicating a group of proteins involved in nuclear RNA metabolism and quality control.","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0098530","count":1},{"id":"GO:0071040","count":1},{"id":"GO:0000460","count":1},{"id":"GO:0045950","count":1},{"id":"GO:0071039","count":1}]},{"hash":"1698005488331705869","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0007004","count":1},{"id":"GO:0031120","count":1},{"id":"GO:1904874","count":1},{"id":"GO:0031118","count":1}]},{"hash":"809262615926204067","title":"Actin cytoskeleton remodeling and cell migration","description":"The cluster is driven by actin dynamics and motility: lamellipodium assembly, regulation of Rho GTPase signaling, and cell migration. While some terms touch on signaling or development, the dominant theme ties to cytoskeletal remodeling enabling movement.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043552","count":7},{"id":"GO:0050853","count":7},{"id":"GO:0016477","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0048538","count":7}]},{"hash":"1352710179381566446","title":"Ribosome biogenesis and translation","description":"The cluster shows strong enrichment for translation (GO:0006412) and ribosome biogenesis (GO:0042254), plus a specific rRNA processing step (ITS1 cleavage), pointing to components of ribosome assembly and protein synthesis. Some transcription-related terms are present but appear secondary to the core ribosome/translation theme.","confidence":"High","size":7,"edges":9,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0042254","count":2},{"id":"GO:0000447","count":1},{"id":"GO:1904803","count":1},{"id":"GO:0032784","count":1}]},{"hash":"653863509347675248","title":"Ubiquitin-Driven Chromatin Remodeling, DNA Repair, and Mitosis","description":"Top GO terms cluster around ubiquitin-related regulation (autoubiquitination, ubiquitin-dependent pathways, K29-linked ubiquitination) and chromatin dynamics (subtelomeric heterochromatin formation, histone demethylation), with links to genome maintenance (nucleotide-excision repair) and cell cycle/mitosis (G2/M transition, spindle elongation). This suggests these proteins coordinate ubiquitin signaling with chromatin state, DNA repair, and mitotic progression.","confidence":"High","size":7,"edges":18,"triangles":22,"max_degree":6,"top_function":"chromatin organization","top_go_terms":[{"id":"GO:0051865","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0070911","count":7},{"id":"GO:0006348","count":6},{"id":"GO:1901044","count":6}]},{"hash":"1560808719905242981","title":"Translation and Ribosome Biogenesis","description":"The top GO terms are centered on translation and ribosome assembly (translation, ribosomal large subunit assembly) with a hint of translation regulation (negative regulation of translation), which together point to a protein cluster involved in the protein synthesis machinery and ribosome biogenesis. The other terms (larval lymph gland hemopoiesis and detection of pheromone) are less directly connected and may reflect broader regulatory roles, but the dominant signal is clearly translation-related.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0017148","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0000027","count":1},{"id":"GO:0035167","count":1},{"id":"GO:0043695","count":1}]},{"hash":"572409824654246055","title":"Mitotic Regulation and Telomere Maintenance","description":"This cluster centers on processes involved in cell division and chromosome maintenance: spindle assembly and mitotic nuclear membrane reassembly point to mitosis, while telomere maintenance and telomere lengthening indicate chromosome end protection and genome stability. The presence of ADP-ribosylation adds a layer of DNA damage response regulation, and the keratinocyte proliferation term aligns with general cell proliferation contexts. Overall, the dominant signal links mitotic regulation with telomere maintenance, justifying this combined label.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010838","count":2},{"id":"GO:0032471","count":2},{"id":"GO:1904908","count":2},{"id":"GO:0007084","count":2},{"id":"GO:1904743","count":2}]},{"hash":"1041263023613222414","title":"Unknown","description":"The cluster has no GO terms provided and a very sparse network (1 edge, 0 triangles, max degree 1), so there is no clear shared function to label it. Therefore, Unknown.","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[]},{"hash":"1844426851461641771","title":"Golgi vesicle trafficking and innate antiviral signaling","description":"This cluster shows a clear enrichment for Golgi/vesicle trafficking (vesicle fusion with Golgi; intracellular protein transport) and innate immune responses to viral infection (dsRNA sensing, type I interferon response, innate immunity). A few cell-cycle related terms are present (APC-dependent catabolic process, cell division), but the dominant theme remains trafficking coupled with antiviral signaling.","confidence":"Medium","size":7,"edges":16,"triangles":20,"max_degree":6,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0048280","count":3},{"id":"GO:0006886","count":3},{"id":"GO:0032781","count":3},{"id":"GO:0050689","count":2},{"id":"GO:0071360","count":2}]},{"hash":"315775188267625767","title":"Developmental Transcriptional Regulation","description":"The terms point to regulation of gene expression by RNA polymerase II across diverse developmental contexts (heart, adrenal, reproductive tissues) and even circadian control, rather than a single molecular function, suggesting a cluster of transcriptional regulators active during development and differentiation.","confidence":"Medium","size":7,"edges":8,"triangles":2,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032922","count":7},{"id":"GO:0009410","count":7},{"id":"GO:0006366","count":6},{"id":"GO:0003218","count":6},{"id":"GO:0007540","count":6}]},{"hash":"725864252401874757","title":"Unknown","description":"The GO terms in this cluster span many unrelated areas (various metabolic pathways, redox processes, LPS response, aging, sperm capacitation, histone methylation), with several obsolete terms as well. There isn\u2019t a single coherent biological function tying all proteins together, so a specific label isn\u2019t justifiable. The dataset also seems to mix pathways across domains, supporting an Unknown classification.","confidence":"","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0008203","count":5},{"id":"GO:0019285","count":5},{"id":"GO:0015945","count":5},{"id":"GO:0046188","count":5}]},{"hash":"928067327952890579","title":"Diverse membrane transport across organelles","description":"The GO terms co-occur in this cluster point to transport or export of various cargos (lipoproteins, fatty acids, amino acids, peptides, ceramide, metals) across membranes and organelle boundaries (peroxisome, mitochondrion, secretion pathways). The variety of substrates and transport types suggests a broad transport-associated cluster rather than a single substrate pathway, hence a label reflecting broad membrane transport.","confidence":"Medium","size":7,"edges":16,"triangles":17,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":6},{"id":"GO:0015910","count":6},{"id":"GO:0046689","count":6},{"id":"GO:0043213","count":6},{"id":"GO:0031460","count":6}]},{"hash":"1014968368645066800","title":"Embryonic Organogenesis","description":"The cluster\u2019s top GO terms cluster around development and morphogenesis across multiple organs and tissues (skeletal muscle, heart, inner ear, forebrain, thyroid, cranial skeleton, visual system). Although some terms touch neural guidance and sensory systems, the overarching theme is embryonic organ development and tissue differentiation, making Embryonic Organogenesis a concise, representative label.","confidence":"High","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007519","count":2},{"id":"GO:0008045","count":2},{"id":"GO:0048839","count":2},{"id":"GO:0050798","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1451843660160779134","title":"Unknown","description":"The top GO terms cover multiple, unrelated biological areas (plant phototropism, immune regulation, development, and ubiquitination), with no clear shared function or pathway linking the proteins. This makes it not possible to assign a coherent, specific label.","confidence":"","size":7,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009638","count":5},{"id":"GO:0048294","count":5},{"id":"GO:0043380","count":5},{"id":"GO:0045497","count":5},{"id":"GO:0031397","count":5}]},{"hash":"2288538758786840539","title":"Craniofacial morphogenesis and airway cartilage formation","description":"This cluster centers on embryonic development of craniofacial structures and related airway cartilage, with terms like primitive streak formation, viscerocranium morphogenesis, roof of the mouth (palate) development, and tracheal cartilage development. There is also involvement of smooth muscle differentiation and signaling pathways (e.g., ERK5 cascade) that support morphogenesis. While a couple of terms seem unrelated (e.g., plant fertilization, some immune terms), the dominant theme is craniofacial morphogenesis and airway cartilage formation. ","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090009","count":6},{"id":"GO:0048703","count":5},{"id":"GO:0060021","count":5},{"id":"GO:1900466","count":3},{"id":"GO:0060025","count":3}]},{"hash":"443107179628467717","title":"RNA processing and translation initiation","description":"The top GO terms cluster around post-transcriptional control of gene expression\u2014mRNA stabilization, spliceosome-assisted splicing regulation, polyadenylation regulation, and small-subunit processome assembly\u2014together with translation initiation processes (eIF4F complex assembly and IRES-dependent initiation). This indicates a coherent group of proteins involved in RNA processing and the initiation of translation, rather than disparate functions. The developmental term (blastocyst formation) appears ancillary. ","confidence":"High","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048255","count":5},{"id":"GO:0034462","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0000381","count":5},{"id":"GO:1900363","count":5}]},{"hash":"1573576463367829678","title":"Developmental Regulation with Immune and Metabolic Signaling","description":"The terms are dominated by development-related processes (exocrine pancreas, midbrain, post-embryonic development) and transcriptional regulation, with notable immune and metabolic signals (leukocyte tethering/rolling, chemokine regulation, glucose response, fibrinolysis). The lack of network connectivity suggests these proteins act as broad regulators across tissues rather than a single pathway, so the name captures the overarching developmental regulatory theme with immune/metabolic associations.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045944","count":5},{"id":"GO:0031017","count":5},{"id":"GO:1903238","count":5},{"id":"GO:0051919","count":5},{"id":"GO:0030901","count":5}]},{"hash":"5459521224593821","title":"Mitochondrial signaling and immune regulation","description":"The terms cluster around mitochondria-related processes (cardiolipin metabolism, stress-induced mitochondrial fusion, mitochondrial morphogenesis) and immune signaling (IL-2 production, T cell polarity), with supporting neural signaling (dopaminergic synaptic regulation) and lipid/protease regulation. This suggests a shared theme of mitochondria-influenced signaling across neural and immune contexts, justifying the name. ","confidence":"Medium","size":7,"edges":11,"triangles":5,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":4},{"id":"GO:0001302","count":4},{"id":"GO:1900210","count":4},{"id":"GO:1903905","count":4},{"id":"GO:0045541","count":4}]},{"hash":"938206319446853552","title":"Unknown","description":"The three GO terms present (palmitoylation, vacuole fusion, and sebaceous gland development) do not point to a single shared function among the seven proteins; the associations are disparate (lipid modification, vesicle trafficking, and tissue development). Therefore there is no clear functional theme to name the cluster.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018230","count":1},{"id":"GO:0042144","count":1},{"id":"GO:0048733","count":1}]},{"hash":"1001873711045620259","title":"Bacterial iron uptake and detoxification","description":"This cluster is dominated by GO terms related to iron handling: iron ion transport, siderophore-iron import, and detoxification of iron ion, suggesting functions in iron acquisition and homeostasis in bacteria. A general stress-response term supports a link between iron metabolism and environmental stress. Some terms (pheromone detection, chromosome condensation, regulation of fibroblast proliferation) appear less coherent with iron-related functions and may reflect annotation noise. Overall, the iron uptake/detoxification theme is the strongest signal.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043695","count":1},{"id":"GO:1904231","count":1},{"id":"GO:0097286","count":1},{"id":"GO:1990461","count":1},{"id":"GO:0048147","count":1}]},{"hash":"1951850540113902032","title":"Developmental Growth Regulation","description":"The terms center on growth- and development-related processes, including chondrocyte proliferation, growth plate cartilage development, and positive regulation of cell growth, with EGFR signaling as a growth-related pathway. While some terms touch on reproductive or immune cell processes, the predominant theme across the cluster is regulation of growth and developmental signaling across tissues, justifying a label focused on developmental growth regulation.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900122","count":1},{"id":"GO:0003417","count":1},{"id":"GO:0045742","count":1},{"id":"GO:0007566","count":1},{"id":"GO:1905523","count":1}]},{"hash":"906721166516780982","title":"Notch-regulated development and O-GalNAc glycosylation","description":"This cluster emphasizes O-GalNAc protein glycosylation and Notch signaling regulation, with related developmental processes (imaginal disc leg segmentation, ovarian follicle development, hypochord development). The connection between O-GalNAc glycosylation and Notch pathway modulation provides a coherent theme linking the GO terms, supporting a Notch-influenced developmental role.","confidence":"High","size":7,"edges":12,"triangles":10,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":4},{"id":"GO:0006486","count":4},{"id":"GO:0016266","count":4},{"id":"GO:0075015","count":4},{"id":"GO:0036011","count":2}]},{"hash":"1028183631575911660","title":"Fatty acid and sphingolipid biosynthesis","description":"All top GO terms point to lipid metabolism, especially various fatty acid biosynthetic processes (long-chain, very long-chain, unsaturated, polyunsaturated) and sphingolipid biosynthesis. Additional terms reference lipid-centric trafficking and pheromone-related signaling, which can be linked to lipid-derived molecules. Taken together, the cluster seems centered on lipid biosynthesis with possible pheromone-related signaling.","confidence":"High","size":7,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007619","count":5},{"id":"GO:0042761","count":5},{"id":"GO:0030148","count":5},{"id":"GO:0006892","count":5},{"id":"GO:0006636","count":5}]},{"hash":"1256382835168525606","title":"Embryonic development and hematopoietic differentiation","description":"This cluster centers on early development signals (primitive streak formation, ectodermal fate, PNS neuron development) and later lineage specification (hematopoietic stem cell proliferation, macrophage differentiation, GM-CSF response), with additional transcriptional regulation (RNA Pol II, miRNA transcription). The common theme appears to be developmental patterning linked to immune/hematopoietic differentiation, though some terms (like vitellogenesis) are broader context. Confidence: Medium","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090009","count":4},{"id":"GO:0048935","count":4},{"id":"GO:0000122","count":4},{"id":"GO:0007296","count":4},{"id":"GO:0097011","count":3}]},{"hash":"192857574791163820","title":"Sister Chromatid Cohesion and Chromosome Condensation","description":"Based on the top GO terms, this cluster centers on cohesin-related processes (mitotic and centromeric sister chromatid cohesion, mitotic chromosome condensation, cohesion maintenance) and chromosome architecture (condensation) during mitosis and meiosis, with supporting DNA repair roles (HR) and meiotic DSB regulation. The terms consistently point to chromosome cohesion/condensation and associated DNA repair activities.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0061780","count":4},{"id":"GO:0000724","count":4},{"id":"GO:1903342","count":4},{"id":"GO:0010032","count":4},{"id":"GO:0000733","count":4}]},{"hash":"753442953452996510","title":"Nuclear RNA processing and chromatin regulation","description":"The terms point to nuclear gene expression control: histone mRNA metabolism, RNAP II transcription termination, splicing machinery assembly, rRNA maturation, and mRNA decapping/import into the nucleus, along with pericentric heterochromatin formation. Together they suggest a cluster of proteins involved in nuclear RNA processing and chromatin dynamics that regulate transcription and RNA maturation, with some plant-stress signaling annotations that may reflect transcriptional responses. Confidence: High","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008334","count":1},{"id":"GO:0006369","count":1},{"id":"GO:1990141","count":1},{"id":"GO:0009737","count":1},{"id":"GO:0051170","count":1}]},{"hash":"1619945016900718181","title":"Apoptosis and Signaling Pathway Regulation","description":"The cluster centers on the apoptotic process and includes multiple signaling pathway regulators (Wnt, JNK, Hippo, insulin signaling, GTPase activity) and differentiation/plasticity terms, suggesting a theme of how cell fate and survival are governed through interconnected signaling cascades. While some terms (e.g., long-term potentiation, keratinocyte differentiation) extend into neural and differentiation contexts, the common thread is signaling cross-talk tied to apoptosis. This supports a cohesive label around cell fate decisions mediated by diverse signaling pathways.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0090263","count":5},{"id":"GO:0046328","count":4},{"id":"GO:0030579","count":4},{"id":"GO:0060291","count":4}]},{"hash":"928193222745945185","title":"Neural differentiation and norepinephrine biosynthesis","description":"The top GO terms point to neural development (ventral spinal cord interneuron differentiation; forebrain neuron differentiation) and norepinephrine biosynthetic process, suggesting these proteins cluster around neural differentiation and catecholamine production. Some immune-related terms are present but less central to the core theme, which is why the label reflects neural development with neurotransmitter biosynthesis rather than a broader immune program.","confidence":"Medium","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021514","count":4},{"id":"GO:0032703","count":4},{"id":"GO:0042421","count":4},{"id":"GO:2000607","count":4},{"id":"GO:0001655","count":4}]},{"hash":"1304353251438769775","title":"Actin Cytoskeleton Remodeling and Protrusion Formation","description":"The cluster's top GO terms mainly involve actin filament polymerization, filopodium and cortex patch assembly/localization, and morphogenesis in dendritic spines and muscle fibers, all pointing to dynamic actin remodeling and membrane protrusions. A couple terms like subtelomeric heterochromatin formation and skeletal muscle fiber development are broader or secondary, but the dominant signal is actin-based cytoskeletal organization.","confidence":"High","size":6,"edges":12,"triangles":11,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030041","count":3},{"id":"GO:0006348","count":2},{"id":"GO:0071963","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0000147","count":2}]},{"hash":"141456450433584333","title":"RNA processing and translation regulation","description":"The proteins cluster around RNA metabolism and control of translation: mRNA localization (oskar), mRNA stabilization, spliceosome-regulated splicing, small-subunit processome assembly (rRNA processing), and assembly of the eIF4F translation initiation complex. These terms point to a shared theme of RNA processing and translation control. Some terms are more peripheral (e.g., obsolete regulation of transcription or hypoxia response) but do not outweigh the core RNA-centric signal.","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045451","count":2},{"id":"GO:0048255","count":2},{"id":"GO:0034462","count":2},{"id":"GO:1901407","count":2},{"id":"GO:0000381","count":2}]},{"hash":"508410104555671911","title":"Trafficking, ubiquitination, and autophagy regulation","description":"The top GO terms point to processes involving endocytosis, protein ubiquitination, mitophagy, and protein localization, with a notable synaptic organization reference (neuroligin clustering). This suggests a cluster focused on intracellular trafficking and protein quality control, including synaptic transport and degradation pathways. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035307","count":6},{"id":"GO:1902459","count":6},{"id":"GO:0010793","count":6},{"id":"GO:0035519","count":6},{"id":"GO:0061734","count":6}]},{"hash":"409274441026148877","title":"RNA Pol II Transcription Regulation","description":"This cluster is driven by GO terms central to transcription by RNA polymerase II, including elongation and initiation-coupled chromatin remodeling, with additional terms for positive regulation and general transcription control. While a few items relate to metabolic cofactor biosynthesis, ubiquitination, or developmental processes, the strongest and most consistent signal is transcriptional regulation by RNA Pol II, suggesting the proteins function primarily in transcription control with possible regulatory or context-dependent roles.","confidence":"Medium","size":6,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006368","count":3},{"id":"GO:0048096","count":3},{"id":"GO:0009229","count":1},{"id":"GO:0009228","count":1},{"id":"GO:0006777","count":1}]},{"hash":"1786424000239096649","title":"Cellular stress response and apoptosis regulation","description":"The top GO terms cluster around stress responses (cadmium exposure, ROS management via SOD), anti-apoptotic regulation, circadian rhythm modulation, and protein turnover via ubiquitin-mediated proteolysis, with supporting roles in calcium transport regulation. Together these suggest a cohesive theme of cellular defense and survival under stress rather than a single pathway.","confidence":"Medium","size":6,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":2},{"id":"GO:0019853","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0042787","count":2}]},{"hash":"2040902070182779557","title":"Fatty acid transport and phenylpropanoid metabolism","description":"The prominent GO terms point to lipid-focused processes, especially various fatty acid transport and metabolism (long-chain, medium-chain, very long-chain) along with phenylpropanoid metabolism linked to seed coat development. Although there are hints of other biosynthetic processes (e.g., NRPS/acetyl-CoA pathways and siderophore synthesis), the dominant theme is lipid metabolism and plant secondary metabolism. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010214","count":6},{"id":"GO:0009698","count":6},{"id":"GO:0008206","count":6},{"id":"GO:0044539","count":6},{"id":"GO:0043041","count":6}]},{"hash":"972991227285518490","title":"Methylation and RNA Modification","description":"The terms are dominated by various methylation processes: tRNA methylation and wobble uridine modification, rRNA methylation, guanine-N7 methylation, and mRNA capping, plus peptidyl-arginine methylation. This points to a cluster centered on methylation/modification activities in both RNA and proteins, with a few peripheral stress-related terms that do not alter the core theme.","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0002098","count":3},{"id":"GO:0009877","count":3},{"id":"GO:0006370","count":3},{"id":"GO:0046690","count":3},{"id":"GO:0036265","count":3}]},{"hash":"1494203014740916165","title":"Unknown","description":"The GO terms are highly diverse, including tRNA splicing, ERK signaling regulation, endocytic recycling, mast cell activation, visual learning, spindle checkpoint regulation, VEGF production, smooth muscle migration, and hypoxia response. With only a few terms represented and little overlap among them, there isn\u2019t a single coherent function or pathway that ties the cluster together. Therefore, I cannot assign a specific functional label; Unknown with None.","confidence":"","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006388","count":1},{"id":"GO:0000379","count":1},{"id":"GO:0070372","count":1},{"id":"GO:2001135","count":1},{"id":"GO:0045576","count":1}]},{"hash":"1035131491184720748","title":"Transcription and Translation Machinery","description":"The cluster has GO terms centered on RNA polymerase II\u2013mediated transcription (initiation/open complex formation, promoter activity, and termination) and on translation and ribosome assembly, indicating proteins involved in core gene expression processes. While two plant-development terms appear, the dominant theme is transcription and translation machinery. ","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0051123","count":1}]},{"hash":"2213935388315595543","title":"Insect eggshell and chorion formation","description":"The terms point to chorion assembly and vitelline membrane formation, key steps in insect eggshell construction, with an accompanying signal of larval chitin-based cuticle development that fits an insect developmental/eggshell context. Overall, the cluster centers on eggshell/chorion formation in insects.","confidence":"High","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0032504","count":2},{"id":"GO:0043443","count":1},{"id":"GO:0008363","count":1},{"id":"GO:0007306","count":1},{"id":"GO:0007305","count":1}]},{"hash":"590350305117606523","title":"Coagulation and Fibrinolysis Cluster","description":"The top GO terms are dominated by blood coagulation and fibrinolysis, with related terms such as positive regulation of fibrinolysis and leukocyte tethering/rolling, suggesting a coagulation\u2013inflammation axis; transcription regulation and development terms appear more peripheral. Overall, the coagulation/fibrinolysis theme best explains the cluster.","confidence":"Medium","size":6,"edges":10,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0042730","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0045944","count":2}]},{"hash":"2150383957592082341","title":"Immune Regulation and Leukocyte Migration","description":"The top GO terms are dominated by immune-modulatory processes, including negative regulation of inflammatory response, negative regulation of leukocyte migration, and regulation of B cell apoptosis, along with cell adhesion. This points to a cluster of proteins involved in dampening inflammation and controlling immune cell movement and survival. Additional terms like response to morphine and dephosphorylation suggest signaling pathways that could connect to immune signaling, while lung development may reflect tissue-specific contexts or developmental regulation. Overall, the cluster seems best described as immune regulation with an emphasis on leukocyte trafficking and survival.","confidence":"High","size":6,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":4},{"id":"GO:0030324","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0016311","count":3},{"id":"GO:0006178","count":2}]},{"hash":"909985194877870404","title":"Developmental Morphogenesis","description":"The GO terms are dominated by body morphogenesis, cuticle development, midbrain and post-embryonic development, indicating a shared focus on developmental processes and tissue/organ formation. A few terms about transcription regulation and metabolic responses are present but appear ancillary to the main developmental theme. ","confidence":"High","size":6,"edges":9,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010171","count":2},{"id":"GO:0040003","count":2},{"id":"GO:0045944","count":1},{"id":"GO:0031017","count":1},{"id":"GO:1903238","count":1}]},{"hash":"40938953189297025","title":"Plant cell wall biosynthesis and O-glycosylation","description":"The cluster is strongly enriched for plant cell wall-related processes (e.g., plant-type secondary cell wall biogenesis, homogalacturonan and glucuronoxylan biosynthesis, mucilage biosynthetic process) and O-linked glycosylation of proteins, indicating a cohesive role in constructing and modifying plant cell wall components. Some terms like skeletal muscle regeneration and glycogen biosynthesis appear as outliers, but the dominant signal points to plant cell wall biosynthesis and associated glycosylation.","confidence":"High","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0043403","count":2},{"id":"GO:0006012","count":2},{"id":"GO:0010417","count":2},{"id":"GO:0016266","count":2}]},{"hash":"1521359287841032378","title":"ER-Golgi trafficking and endocytosis cluster","description":"The GO terms center on vesicle trafficking within the endomembrane system: protein targeting to vacuole, ER\u2013Golgi vesicle transport, Golgi\u2013ER retrograde transport, and endocytosis. These define a cohesive theme around intracellular transport between key compartments, with additional hints of regulatory processes (cell cycle, kinase activity) that may modulate these pathways. Overall, the dominant function is vesicle trafficking and endocytosis within the ER-Golgi-vacuole axis.","confidence":"Medium","size":6,"edges":5,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006623","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0006897","count":3},{"id":"GO:0051301","count":3}]},{"hash":"1517340185366294334","title":"Neural development and Toll-AMP regulation","description":"Predominantly neural development signals (CNS formation, motor neuron axon guidance, regulation of synaptic plasticity) with concurrent annotations for Toll signaling and antimicrobial peptide biosynthesis, suggesting a cluster of proteins involved in neural development that are also linked to innate immune regulation and AMP production. The connections are plausible but not strongly cohesive across all terms, hence moderate confidence.","confidence":"Medium","size":6,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021556","count":3},{"id":"GO:0008592","count":3},{"id":"GO:0008045","count":3},{"id":"GO:0006965","count":3},{"id":"GO:0019732","count":3}]},{"hash":"1443354127919401510","title":"Mitochondrial protein import and Fe-S cluster biogenesis","description":"This cluster centers on mitochondrial protein handling: targeting to mitochondrion, chaperone-assisted transport, and insertion into the inner membrane, together with iron-sulfur cluster assembly and metal ion homeostasis. The co-occurrence suggests a coherent theme of mitochondrial protein import and Fe-S biogenesis, with some related vacuolar and nitrogen-fixation annotations likely peripheral or cross-annotation.","confidence":"Medium","size":6,"edges":13,"triangles":12,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006626","count":3},{"id":"GO:0072321","count":2},{"id":"GO:0045039","count":2},{"id":"GO:0009399","count":1},{"id":"GO:0006879","count":1}]},{"hash":"2175467147887080658","title":"Neural synapse formation and signaling","description":"These proteins are primarily linked to nervous system development and synaptic function: axon guidance, synapse maturation/assembly, and excitatory synaptic transmission, along with related behaviors (vocalization, prepulse inhibition) and neural development processes. The cluster seems to represent components involved in axonal targeting and synaptic connectivity, with broader developmental roles.","confidence":"High","size":6,"edges":13,"triangles":13,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0010762","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0090126","count":2},{"id":"GO:2000463","count":2},{"id":"GO:0007268","count":2}]},{"hash":"710427173820821966","title":"Insect melanization and wound immunity","description":"This cluster is dominated by GO terms for melanin biosynthesis from tyrosine, melanotic encapsulation of foreign targets, scab formation, and hemolymph coagulation, all hallmark features of insect innate immune defense and wound repair via melanization and coagulation. Other terms like proteolysis and catalytic activity support immune effector functions, while some terms are ancillary but compatible with this core theme.","confidence":"High","size":6,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904715","count":5},{"id":"GO:0046938","count":5},{"id":"GO:0043085","count":5},{"id":"GO:0006508","count":5},{"id":"GO:0042381","count":1}]},{"hash":"1159514643661210974","title":"Unknown","description":"The GO terms span plant reproduction (pollen tube guidance, pollen germination), neural development (neural tube formation, dendritic spine maintenance), immune cell biology (myeloid progenitor proliferation, myeloid cell homeostasis, T cell selection), and lipid signaling (phosphatidylinositol phosphate biosynthesis) with no single cohesive theme across the cluster; thus no specific, representative label can be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046854","count":1},{"id":"GO:0002262","count":1},{"id":"GO:0010183","count":1},{"id":"GO:0097062","count":1},{"id":"GO:0010919","count":1}]},{"hash":"340439858946516976","title":"Wnt-Driven Developmental Regulation","description":"The top GO terms cluster around Wnt signaling and developmental processes, with several entries about developmental regulation of transcription (RNA polymerase II) and tissue-specific development (pancreas, midbrain, post-embryonic). This suggests proteins in this cluster commonly participate in Wnt-mediated development and associated transcriptional control. ","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":6},{"id":"GO:0045944","count":5},{"id":"GO:0031017","count":5},{"id":"GO:1903238","count":5},{"id":"GO:0051919","count":5}]},{"hash":"1913197536733751517","title":"Transmembrane ion and sugar transport","description":"The top GO terms are dominated by transmembrane transport across the plasma membrane for multiple substrates (phosphate, nitrate, potassium, selenite, D-glucose, D-xylose, etc.), with an additional related term for osmotic stress, suggesting the proteins function as or with membrane transporters. Some terms about epithelial structure and senescence are less central to the cluster\u2019s core function. Overall, the signal points to a transporter-related group.","confidence":"High","size":6,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":5},{"id":"GO:0015706","count":4},{"id":"GO:0060731","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006970","count":4}]},{"hash":"1308141094077215302","title":"Golgi- and SNARE-Mediated Neuronal Vesicle Trafficking","description":"The GO terms point to Golgi ribbon formation, SNARE assembly, and vesicle transport through the secretory pathway, including delivery of receptors to the postsynaptic membrane and links to synaptic plasticity, suggesting a neuron-specific vesicle trafficking module centered on the Golgi.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":3},{"id":"GO:0035493","count":3},{"id":"GO:0098967","count":3},{"id":"GO:0048280","count":3},{"id":"GO:0006888","count":3}]},{"hash":"1915219390289593350","title":"Neuronal development and vesicle transport","description":"Top GO terms emphasize microtubule-based movement and spinal cord development, with supporting hints from synaptic vesicle budding, suggesting a theme of neural development and presynaptic trafficking. Some immune-related terms appear but do not override the main neuronal-focused signal.","confidence":"Medium","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007018","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0071375","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0035994","count":2}]},{"hash":"526781437435452689","title":"Broad Signal Transduction Across Systems","description":"The proteins appear to participate in diverse signal transduction processes across systems, including immune (interleukin-1, T cell receptor), neural (glutamatergic synaptic transmission, long-term potentiation), vascular/growth (angiogenesis), plant signaling (abscisic acid-activated), and growth-related signaling, with an additional link to cell cycle regulation. This mix suggests a broad, cross-context signaling role rather than a single cohesive pathway, hence a general label for signal transduction across multiple systems. ","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":5},{"id":"GO:0070498","count":5},{"id":"GO:0001402","count":5},{"id":"GO:0009738","count":5},{"id":"GO:0034351","count":5}]},{"hash":"2216973132136394912","title":"Tagatose-6-phosphate sugar catabolism","description":"The top GO terms prominently point to tagatose-6-phosphate\u2013related catabolic pathways (lactose catabolic via tagatose-6-phosphate and D-tagatose 6-phosphate catabolic process), complemented by various sugar metabolic and nucleotide salvage terms. Although there are outlier obsolete terms (gastrulation, histone deacetylation, aging), the core signal is carbohydrate metabolism centered on tagatose-6-phosphate, suggesting a cohesive function in sugar catabolism.","confidence":"High","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007369","count":2},{"id":"GO:0016575","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0006169","count":2},{"id":"GO:2001059","count":2}]},{"hash":"1550269478373819902","title":"TGF-beta signaling in development","description":"The cluster shows strong enrichment for SMAD signaling and positive regulation of TGF-beta receptor signaling, pointing to TGF-beta\u2013driven regulation during development. Development-related terms such as lens fiber cell differentiation and seminiferous tubule development anchor the theme, with additional transcription and ribosome biogenesis terms reflecting general cellular activity accompanying differentiation. Some stress-related terms exist but do not define the core theme. ","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0072520","count":4},{"id":"GO:0070306","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0071276","count":3},{"id":"GO:0030433","count":3}]},{"hash":"1318136045287472056","title":"DNA replication and cell cycle machinery","description":"The top GO terms cluster around DNA replication, including replication initiation, pre-replicative complex assembly, and cell division, pointing to proteins involved in DNA synthesis and progression through the cell cycle. Additional terms about RNA metabolism and stress responses are present but secondary to the replication-centric theme.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0035617","count":2},{"id":"GO:0040016","count":2},{"id":"GO:0006267","count":2},{"id":"GO:0006270","count":2}]},{"hash":"528636027878152390","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The cluster is dominated by actin/cytoskeleton-related terms: mesenchyme migration, actin cortical patch localization, and mitotic actomyosin contractile ring assembly, pointing to cytoskeletal remodeling and cell movement. Some chromatin-related terms and gene expression regulation appear but are less central to the core theme. ","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":5},{"id":"GO:1904623","count":5},{"id":"GO:0090131","count":5},{"id":"GO:0051666","count":5},{"id":"GO:0006348","count":5}]},{"hash":"532235657698937903","title":"Heterochromatin Maintenance and Boundary Regulation","description":"This cluster is dominated by heterochromatin organization: formation, maintenance, and boundary establishment, with associated histone modification activity (notably H4 acetylation) reflected in the GO terms. A related estradiol response hint may indicate chromatin remodeling under hormonal signaling, but the core theme remains epigenetic silencing and chromatin architecture.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0032703","count":2},{"id":"GO:1902368","count":2},{"id":"GO:0001207","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0043982","count":2}]},{"hash":"1920128106391165800","title":"Photoperiodic flowering regulation","description":"The GO terms cluster around flowering development, inflorescence development, and timing transitions from vegetative to reproductive phases, especially short-day photoperiodism, indicating a role in controlling when and how flowering occurs.","confidence":"High","size":5,"edges":8,"triangles":5,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0048575","count":1},{"id":"GO:0009908","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0010229","count":1},{"id":"GO:0048510","count":1}]},{"hash":"659487084998456866","title":"Spliceosome Assembly and mRNA Processing","description":"The top GO terms converge on RNA splicing and processing (spliceosome assembly, tri-snRNP, regulation of alternative mRNA splicing, small-subunit processome), with additional hints of mRNA stabilization and ribonucleoprotein biogenesis. The neural-related terms likely reflect downstream phenotypes rather than core function. Overall, the cluster centers on RNA splicing machinery and mRNA processing.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051967","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0000244","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0034462","count":1}]},{"hash":"1611412930752182398","title":"Protein Modification and Trafficking Regulation","description":"The cluster includes GO terms tied to post-translational modification (sumoylation, deubiquitination), membrane targeting/ER insertion, protein folding, and broader regulation of gene expression, suggesting a theme of protein-level regulation and trafficking rather than a single enzymatic pathway. Given the variety, the label focuses on protein processing, modification, and trafficking as the core unifying concept.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010216","count":5},{"id":"GO:0071816","count":5},{"id":"GO:0045944","count":5},{"id":"GO:0045759","count":5},{"id":"GO:0002109","count":5}]},{"hash":"36029576035246594","title":"Ras-ERK/MAPK Signaling in Development and Differentiation","description":"This cluster is dominated by GO terms pointing to ERK1/ERK2 cascade regulation and the Sevenless signaling pathway, both central to Ras/MAPK signaling. Additional terms about receptor internalization, stem cell differentiation, and cerebellum morphogenesis connect signaling to development and immune-related proliferation, suggesting a coordinated role of MAPK signaling in development and differentiation processes. Some entries are tangential (proteasomal degradation, obsolete terms), but overall the shared theme centers on ERK/MAPK-driven signaling in development and differentiation.","confidence":"Medium","size":5,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032436","count":5},{"id":"GO:0048863","count":5},{"id":"GO:0021587","count":4},{"id":"GO:0046641","count":4},{"id":"GO:1904528","count":4}]},{"hash":"1159210771688758843","title":"Ribosome Biogenesis and Translation","description":"The strongest signals are ribosome-related processes: translation, ribosome biogenesis, cytosolic ribosome assembly, and rRNA processing, defining a common theme of ribosome production and protein synthesis. Secondary terms like centrosome duplication, macroautophagy, and metal stress responses are less central, so the core label centers on ribosomal machinery.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0042273","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0006364","count":1},{"id":"GO:0051298","count":1}]},{"hash":"2206505220195632852","title":"Nuclear transcription and RNA processing","description":"This cluster centers on DNA-templated transcription and mRNA splicing, along with RNA decay and exonuclease activities, pointing to a cohesive role in nuclear gene expression, RNA maturation, and turnover. The angiogenesis-related term appears incidental and does not define the main theme.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0009154","count":1},{"id":"GO:0000288","count":1}]},{"hash":"1075097093653013780","title":"Protein oligomerization and complex formation","description":"The top GO terms are dominated by protein\u2013protein interaction and assembly processes\u2014heterooligomerization, homotetramerization, and positive regulation of oligomerization\u2014suggesting the core theme is formation of protein complexes. While other terms (mitochondrial respiration, ubiquitin recycling, symbiont entry) appear, they are peripheral to the central motif of oligomerization and complex assembly.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071432","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0009060","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0051289","count":2}]},{"hash":"1155285655018343230","title":"Unknown","description":"These proteins show a wide mix of GO terms across plants, microbes, and animals: seed coat development, phenylpropanoid metabolism, bile acid metabolism, fatty acid transport, siderophore biosynthesis, and even social behavior. The terms do not point to a unifying function or pathway, and the network is sparse (no triangles, max degree 1), so there is no coherent label beyond Unknown.","confidence":"","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":2},{"id":"GO:0010214","count":1},{"id":"GO:0009698","count":1},{"id":"GO:0008206","count":1},{"id":"GO:0019629","count":1}]},{"hash":"1046907659614706549","title":"Mitochondrial translation and respiration","description":"The top terms cluster around mitochondrial functions: mitochondrial translation, mitochondrial ribosome assembly, and mitochondrial electron transport, indicating a role in mitochondrial protein synthesis and respiration. While a couple terms are more general or incidental (e.g., ER organization, carbon-related responses), the strongest shared theme is mitochondrial gene expression linked to energy metabolism.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070681","count":2},{"id":"GO:0009062","count":2},{"id":"GO:0019876","count":2},{"id":"GO:0032543","count":2},{"id":"GO:0007029","count":2}]},{"hash":"393735572507375440","title":"Ubiquitin-proteasome Regulation of Immune Signaling","description":"The cluster centers on ubiquitin-proteasome system processes (proteasome assembly, deubiquitination, ubiquitin-independent proteolysis) and immune/inflammatory signaling (non-canonical NF-kappaB, TNF signaling, inflammatory response), with additional links to antiviral processes and signaling pathway regulation (e.g., Wnt), suggesting a cohesive role in modulating immune signaling through protein turnover.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0090090","count":2},{"id":"GO:0010950","count":2},{"id":"GO:0016032","count":2},{"id":"GO:0016579","count":1},{"id":"GO:0002862","count":1}]},{"hash":"1467361638548291632","title":"Meiotic Chromosome Segregation and Cell Division","description":"The cluster is strongly enriched for meiotic-related and cell division processes: cell division, meiotic chromosome separation, and synaptonemal complex assembly are prominent, suggesting a core role in meiosis and chromosome segregation, with supporting vesicle trafficking/assembly terms that may relate to meiotic membrane and protein complex dynamics.","confidence":"High","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006888","count":3},{"id":"GO:0006461","count":2},{"id":"GO:0009959","count":2},{"id":"GO:2001241","count":2}]},{"hash":"709456430610443657","title":"Unknown","description":"The GO terms are a mix of plant-specific processes (auxin signaling, leaf formation) and disparate metabolic and genetic processes (PQQ and biotin/lipoate biosynthesis, DNA transformation, antibiotic response, cytoskeletal organization) with no clear shared function or interaction pattern, so there is no coherent theme to label; hence Unknown with no confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010928","count":1},{"id":"GO:2000025","count":1},{"id":"GO:0018189","count":1},{"id":"GO:0048789","count":1},{"id":"GO:0046677","count":1}]},{"hash":"974498823402658724","title":"DNA repair and tRNA charging","description":"This cluster is enriched for DNA repair and DNA recombination terms, plus tRNA aminoacylation and regulation of translational fidelity, pointing to a theme of genome maintenance alongside translation-related processing. Although some terms seem less coherent (e.g., ionomycin response), the core signal ties nucleic acid maintenance with translation readiness.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:0006450","count":1},{"id":"GO:0070143","count":1},{"id":"GO:0006435","count":1},{"id":"GO:0090305","count":1}]},{"hash":"1035765469995839674","title":"Chromatin, centromere assembly, and mitosis","description":"The top GO terms point to nuclear processes: CENP-A\u2013containing chromatin assembly, mitotic cell cycle, chromosome segregation, and related chromatin modifications and DNA replication steps, suggesting a chromatin-centric, centromere/mitosis-focused cluster. A few terms (collagen fibril organization, cytokine production) appear unrelated and may reflect annotation noise, but the core signals align with chromatin organization and mitosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032504","count":1},{"id":"GO:0030199","count":1},{"id":"GO:0018401","count":1},{"id":"GO:0035185","count":1},{"id":"GO:1903461","count":1}]},{"hash":"1423514683448890979","title":"Melanosome Transport and Membrane Trafficking","description":"The cluster is dominated by GO terms tied to intracellular transport and membrane trafficking, notably melanosome transport, Golgi vesicle docking, and regulation of protein localization to the plasma membrane, suggesting a cohesive theme around pigment-related trafficking and membrane dynamics, with other terms reflecting regulatory layers. Confidence: Medium","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0010629","count":5},{"id":"GO:0001667","count":5},{"id":"GO:0045859","count":5},{"id":"GO:0000186","count":5},{"id":"GO:1903078","count":5}]},{"hash":"585363229009169002","title":"Mitochondrial Respiratory Chain Assembly and ATP Synthesis","description":"This cluster centers on the assembly of mitochondrial electron transport chain components (complex II and III), cristae formation, and the proton-motive-force\u2013driven ATP synthesis, with supporting evidence from protein complex oligomerization. An unrelated term about substantia nigra development is present but does not change the central mitochondria-focused theme.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":1},{"id":"GO:0042407","count":1},{"id":"GO:0006122","count":1},{"id":"GO:0034551","count":1},{"id":"GO:0015986","count":1}]},{"hash":"252374428641301635","title":"Glutamatergic synaptic transmission","description":"This cluster is dominated by terms tied to neuronal communication: glutamate secretion, chemical synaptic transmission, and positive regulation of excitatory postsynaptic potential, plus nitric oxide\u2013mediated retrograde signaling and vocalization behavior. These collectively point to function at glutamatergic synapses and their regulation, with a few peripheral terms (opsonization, bile acid secretion) contributing minimally to the overall theme.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":3},{"id":"GO:1903028","count":3},{"id":"GO:2000463","count":2},{"id":"GO:0014047","count":2},{"id":"GO:0030033","count":2}]},{"hash":"372228328059807721","title":"Regulatory Proteins Across Development and Metabolism","description":"The GO terms show a strong emphasis on regulatory activity (positive/negative regulation) across diverse contexts\u2014development (kidney, spermatogenesis, bone), metabolism (fatty acid biosynthesis), redox control (SOD activity), and signaling (calcium transport regulation). This suggests the cluster comprises general regulatory proteins affecting multiple pathways rather than a single, cohesive pathway, hence the broad label focusing on regulatory roles across development and metabolism. ","confidence":"Medium","size":5,"edges":7,"triangles":4,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007568","count":1},{"id":"GO:0010922","count":1},{"id":"GO:0001822","count":1},{"id":"GO:1901896","count":1},{"id":"GO:1901671","count":1}]},{"hash":"460874146519533860","title":"Glycolysis and PPP Regulation","description":"This cluster is dominated by metabolic regulation of carbohydrate processing, with emphasis on glycolysis control (fructose 2,6-bisphosphate metabolism, carbohydrate phosphorylation) and pentose phosphate pathway flux (regulation of the PPP shunt). Dephosphorylation as a regulatory mechanism and glucose catabolism redirection to lactate via pyruvate further support a theme of energy flux balancing. Autophagy and respiratory burst appear as related stress-energy responses, but the core signal ties to glucose metabolism control. ","confidence":"High","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"autophagy","top_go_terms":[{"id":"GO:0016311","count":4},{"id":"GO:0045730","count":3},{"id":"GO:0006914","count":3},{"id":"GO:0033133","count":3},{"id":"GO:0071279","count":3}]},{"hash":"1207374559809382813","title":"Fatty acid biosynthesis","description":"In this cluster, the strongest signals are GO terms related to fatty acid biosynthesis: malonyl-CoA biosynthetic process, long-chain fatty acid biosynthetic process, and fatty acid biosynthetic process, pointing to lipid production pathways as the shared function. Other terms present (protein metabolic process, N-glycan processing, heart morphogenesis, neuromuscular process) are sparse and do not define a cohesive theme, so the main pattern is lipid biosynthesis. This leads to labeling the cluster as fatty acid biosynthesis, with moderate confidence due to some noise from non-lipid terms. ","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001295","count":1},{"id":"GO:0019552","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0044268","count":1},{"id":"GO:0006633","count":1}]},{"hash":"98927780442853197","title":"Developmental Regulation and Metabolic Homeostasis","description":"The top GO terms point to tissue development (trachea cartilage, retinal pigment epithelium, adipose tissue, prostate morphogenesis) and metabolic processes (cholesterol homeostasis, glucose regulation), with DNA-templated transcription suggesting regulatory roles. The combination suggests a cluster of transcriptional regulators involved in coordinating development and metabolism across multiple tissues rather than a single pathway.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0060534","count":1},{"id":"GO:0061469","count":1},{"id":"GO:2000189","count":1},{"id":"GO:0032331","count":1}]},{"hash":"1256760991679005767","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0006006","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0009089","count":2},{"id":"GO:0035606","count":2}]},{"hash":"1554708973718960580","title":"Steroid hormone biosynthesis and lipid metabolism","description":"The GO terms are dominated by steroid-related processes (progesterone biosynthetic process; glucocorticoid metabolic process) and lipid-related pathways (bile acid secretion/biosynthesis; ceramide transport), suggesting a common theme of steroid hormone production and lipid metabolism under endocrine regulation, with supportive notes on hormone signaling and vascular effects.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0032782","count":1},{"id":"GO:0070859","count":1},{"id":"GO:0042747","count":1},{"id":"GO:0097498","count":1}]},{"hash":"471526077711158665","title":"Unknown","description":"The GO terms are highly diverse: calcium homeostasis, various ion transports, cytoskeletal/organellar organization, immune cell differentiation, sensory perception, and glycoside response. There is no single cohesive function tying these proteins together, so a precise functional label can\u2019t be assigned beyond Unknown.","confidence":"","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051208","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0002329","count":1},{"id":"GO:0060052","count":1},{"id":"GO:0033292","count":1}]},{"hash":"2112818749472904226","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032361","count":3},{"id":"GO:0071318","count":3},{"id":"GO:0097755","count":3},{"id":"GO:0006874","count":3},{"id":"GO:0071577","count":3}]},{"hash":"171747161414583990","title":"Calcium and ion transport in muscle and neural signaling","description":"This cluster centers on ion transport and calcium handling, with GO terms for calcium export, mitochondrial calcium homeostasis/transport, and multiple links to calcium-regulated muscle (skeletal and heart) function, plus synaptic plasticity (long-term potentiation/depression). The shared theme is ion transport and calcium signaling governing muscle and neural activities.","confidence":"High","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010163","count":1},{"id":"GO:0014819","count":1},{"id":"GO:0006828","count":1},{"id":"GO:0098735","count":1},{"id":"GO:0060292","count":1}]},{"hash":"786924167061238415","title":"Excitatory synapse formation and trafficking","description":"Proteins in this cluster are linked to the development and function of excitatory synapses. GO terms include excitatory synapse assembly, positive regulation of excitatory postsynaptic potential, neuron cell-cell adhesion, and cytoskeletal organization at the active zone, all pointing to synapse formation and maturation. Receptor recycling regulation suggests trafficking at the postsynaptic membrane, aligning with synaptic plasticity and learning; neuroblast differentiation supports neuronal development that underpins synapse formation. Some terms like iodide transport appear ancillary but do not overshadow the core synaptic theme.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":1},{"id":"GO:1904861","count":1},{"id":"GO:0001919","count":1},{"id":"GO:2000463","count":1},{"id":"GO:0007158","count":1}]},{"hash":"1802872510109995865","title":"Pheromone Sensing and Social Behavior","description":"The cluster\u2019s top GO terms point to olfactory/pheromonal detection (response to pheromone, sensory perception of smell) and social behavior, with transport as a possible supporting function. This combination suggests proteins involved in pheromone signaling that influences social interactions, even though the network is sparse. Therefore, labeling it as pheromone sensing relevant to social behavior captures the core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019236","count":1},{"id":"GO:0007608","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0035176","count":1}]},{"hash":"1737858874652805034","title":"Neurovascular and cardiac development with metabolism","description":"Top terms cover neural development (neuron migration, cortical layer formation), cardiac/vascular development (heart trabecula formation, regulation of blood pressure), VEGF signaling, GPCR signaling, and mitochondrial energy production. This suggests a cluster of proteins coordinating neurovascular and cardiac development with metabolism.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":4},{"id":"GO:0045777","count":4},{"id":"GO:0022900","count":4},{"id":"GO:0060347","count":2},{"id":"GO:0001764","count":2}]},{"hash":"1000993650225403054","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0048701","count":4},{"id":"GO:0031124","count":2},{"id":"GO:0001178","count":2},{"id":"GO:0016973","count":2}]},{"hash":"1225012165359250486","title":"Drosophila Development and Patterning","description":"The set of GO terms centers on transcriptional regulation during insect development and patterning, including DNA-templated transcription and its regulation, antennal and compound eye/photoreceptor development, dorsal/ventral axis specification, left-right pattern formation, and ecdysteroid signaling that shapes development. Although some terms like cartilage morphogenesis or pancreatic cell development appear as distant annotations, the dominant theme is transcriptional control guiding sensory organ formation and embryonic patterning in insects, particularly Drosophila.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0060972","count":1}]},{"hash":"1833003066030529753","title":"Mitochondrial inner-membrane protein insertion","description":"Based on the GO terms, the cluster centers on proteins involved in importing proteins into the mitochondrial inner membrane, notably the specific step of insertion from the matrix into the inner membrane (GO:0032979). The general protein transport term (GO:0015031) supports this theme, while the obsolete reproduction term is likely noise and not representative of the cluster\u2019s function.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0032504","count":2},{"id":"GO:0015031","count":1},{"id":"GO:0032979","count":1}]},{"hash":"524955020605630952","title":"Meiosis and Oogenesis Machinery","description":"These terms cluster around meiotic processes (synaptonemal complex assembly, meiotic sister chromatid cohesion, meiotic recombination checkpoint signaling, spindle assembly/checkpoints) and gametogenesis (meg as porogenesis, oogenesis), with related cell division activity. The proteins are thus best described as components of the meiotic/meiosis-related oogenesis machinery.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009554","count":1},{"id":"GO:0007130","count":1},{"id":"GO:0000070","count":1},{"id":"GO:0051177","count":1},{"id":"GO:0051598","count":1}]},{"hash":"1067377175950916804","title":"Neural development and stress-response signaling","description":"The terms prominently point to brain development processes (initiation of neural tube closure, third ventricle development) and neuronal stress responses (oxidative stress-induced apoptosis, responses to methylmercury and cadmium), with supporting ideas from ubiquitination and cell cycle checkpoints. This combination suggests a cluster centered on neural development linked to stress-signaling pathways, hence the label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000209","count":1},{"id":"GO:0042752","count":1},{"id":"GO:0021993","count":1},{"id":"GO:1903378","count":1},{"id":"GO:0071406","count":1}]},{"hash":"1323546975572244542","title":"Protein quality control under oxidative stress","description":"This cluster centers on protein maintenance and redox responses, with GO terms for protein repair (GO:0030091), protein modification (GO:0006464), and response to oxidative stress (GO:0006979), plus a redox-related term (GO:0055114). While a few synaptic or developmental terms appear, the dominant signal is the repair/modification of proteins in the context of oxidative challenges.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030091","count":3},{"id":"GO:0006464","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006979","count":3},{"id":"GO:2000463","count":1}]},{"hash":"1129280070914496616","title":"Actin remodeling and filopodia-driven migration","description":"The cluster is dominated by GO terms pointing to actin cytoskeleton dynamics and protrusive structures (actin filament branching, filopodium assembly, substrate-dependent cell migration), and by signaling events tied to growth factors (PDGF, HGF) that promote cytoskeletal rearrangement and movement. While a few terms (e.g., cerebellum morphogenesis, IL-2 production) are less directly related, the core theme is actin-driven remodeling and migratory behavior.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021587","count":4},{"id":"GO:0010641","count":4},{"id":"GO:0006930","count":4},{"id":"GO:0045737","count":4},{"id":"GO:1900042","count":4}]},{"hash":"69867609748422400","title":"NF-kappaB Signaling and Ubiquitination","description":"The top GO terms show a strong emphasis on positive regulation of canonical NF-kappaB signaling, along with protein polyubiquitination and regulation of inflammatory response, suggesting a central theme around NF-kappaB pathway regulation modulated by ubiquitination. Other terms relate to development and mitosis, but the NF-kappaB/ubiquitination axis appears to be the core connection among the functions.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043123","count":3},{"id":"GO:0060711","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0061469","count":2},{"id":"GO:0007058","count":2}]},{"hash":"711991398259155852","title":"Sugar catabolism and nucleotide salvage","description":"These proteins are enriched for a range of sugar catabolic processes (tagatose-6-phosphate, lactose, fructose, sucrose, ribose, and sulfoquinovose) and related carbohydrate phosphorylation, with additional nucleotide salvage activities (adenosine and AMP salvage) and dATP biosynthesis. This points to a metabolism-focused cluster centered on carbohydrate breakdown, with supporting nucleotide turnover functions. ","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001059","count":3},{"id":"GO:0019512","count":3},{"id":"GO:1902777","count":3},{"id":"GO:0006169","count":2},{"id":"GO:0009750","count":2}]},{"hash":"619405187545214704","title":"Proteostasis under oxidative stress","description":"This cluster is dominated by GO terms related to protein maintenance and quality control, including protein repair (GO:0030091), protein modification (GO:0006464), and the explicit response to oxidative stress (GO:0006979). While there are some localization/trafficking terms present (e.g., protein import/localization), the strongest signal is maintaining protein function and handling oxidative damage, suggesting a theme of proteostasis under stress.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030091","count":3},{"id":"GO:0006464","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006979","count":3},{"id":"GO:0044053","count":1}]},{"hash":"544959968667008708","title":"Neural development and synaptic differentiation","description":"The set of GO terms centers on nervous system development and function: astrocyte differentiation, substantia nigra development, and excitatory postsynaptic potential point to CNS development and synaptic activity. Additional terms like EMT and mitotic cell cycle can occur in developmental contexts, while others (e.g., cAMP response, miRNA processing) suggest broader regulatory signaling. Overall, the cluster appears best described by neural development and synaptic differentiation, though some terms are peripheral. ","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905205","count":1},{"id":"GO:0051591","count":1},{"id":"GO:0051562","count":1},{"id":"GO:0048708","count":1},{"id":"GO:0000278","count":1}]},{"hash":"289876802740353004","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097175","count":2},{"id":"GO:0097173","count":2},{"id":"GO:0034219","count":2},{"id":"GO:0070981","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1329392933827631723","title":"Membrane transporters for ions and sugars","description":"This cluster is dominated by GO terms describing transmembrane transport of nutrients and ions (nitrate, potassium, selenite, organic cations, glucose, xylose, etc.) and related osmotic stress responses, suggesting the proteins function primarily as plasma membrane transporters for ions and sugars. A few terms about epithelial maintenance or senescence are less central but may reflect context-specific regulation. Overall, a coherent theme is transport across the membrane for nutrient and ion uptake and osmotic balance.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":4},{"id":"GO:0060731","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006970","count":4},{"id":"GO:0097080","count":4}]},{"hash":"1353477810334947455","title":"Unknown","description":"The top GO terms span several unrelated processes (mitotic cell cycle/cell division, pollen maturation/inflorescence development, defense responses, miRNA transcription, protein ubiquitination and sumoylation regulation, and cytoskeleton-dependent transport). There isn\u2019t a single cohesive functional theme linking these proteins, so a concise, representative label isn\u2019t clear. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0019835","count":1},{"id":"GO:0042742","count":1},{"id":"GO:0010152","count":1},{"id":"GO:0010229","count":1}]},{"hash":"1749735339384815056","title":"Developmental chromatin remodeling and epigenetic regulation","description":"The cluster is dominated by chromatin dynamics and histone modification terms (nucleosome disassembly, chromatin remodeling, histone methylation), with several development-related processes (uterus morphogenesis, Sertoli cell barrier establishment, neuroblast fate) linking chromatin control to tissue morphogenesis. The inclusion of the RITS complex localization further supports a chromatin-based regulation theme. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061038","count":3},{"id":"GO:0006337","count":3},{"id":"GO:0097368","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0014017","count":2}]},{"hash":"777556718439097308","title":"Mitosis and ER-Golgi vesicle trafficking","description":"Top GO terms indicate a link between cell division processes (mitotic cell cycle, mitotic spindle assembly, cell division, cell population proliferation) and vesicle trafficking between the ER and Golgi (COPII budding, ER-to-Golgi transport, Golgi-to-ER transport), with supportive development-related terms (brain development, multicellular organism growth). This suggests a cluster where mitotic machinery intersects with the secretory pathway, possibly reflecting growth contexts. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000278","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006888","count":2}]},{"hash":"2174305546310809583","title":"Unknown","description":"The top GO terms span steroid and xenobiotic metabolism (androgen, progesterone, coumarin, camphor, vitamin D), ion responses (cesium, potassium), and some immune modulation (negative regulation of chronic inflammatory response, macrophage chemotaxis). This mix does not point to a single cohesive function or pathway, making a specific, representative label difficult to justify.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":4},{"id":"GO:0019383","count":4},{"id":"GO:0010164","count":4},{"id":"GO:0035865","count":4},{"id":"GO:0046226","count":4}]},{"hash":"2078228196365315818","title":"Mitochondrial Redox Homeostasis and Detoxification","description":"GO terms cluster around redox balance and detoxification of oxidants, with deglutathionylation and mitochondrial intermembrane space protein import supporting a theme of mitochondrial redox regulation; some terms are obsolete or peripheral (nuclear transport, autophagy regulation), but the dominant pattern is redox control in mitochondria.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0045454","count":3},{"id":"GO:0098869","count":3},{"id":"GO:0016242","count":2},{"id":"GO:1903206","count":2}]},{"hash":"1597350649434189316","title":"Single-Strand Break Repair","description":"This cluster is defined by a shared GO term for single-strand break repair, suggesting the proteins participate in processing or repairing single-stranded DNA breaks. With four proteins all annotated to this process, the group likely represents components of the SSB repair pathway, though the evidence is limited to one term, so this is a best-fit label rather than definitive.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000012","count":1}]},{"hash":"1465379855529849080","title":"Starch and alpha-glucan metabolism","description":"The GO terms are dominated by starch biosynthetic processes (starch, amylopectin, alpha-glucan biosynthesis) and by catabolic pathways of related storage carbohydrates (glycogen, maltose, trehalose), indicating a cohesive module for storage carbohydrate assembly and breakdown.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0019252","count":3},{"id":"GO:0044245","count":3},{"id":"GO:0030979","count":3},{"id":"GO:0005980","count":3},{"id":"GO:0051692","count":3}]},{"hash":"1868083697923077146","title":"Mitochondrial lipid metabolism and fusion","description":"The top GO terms are dominated by mitochondrial lipid biosynthesis and dynamics, including cardiolipin biosynthetic process, phosphatidic acid biosynthetic process, lipid catabolic process, and positive regulation of mitochondrial fusion, suggesting a coherent theme around mitochondrial membrane lipid metabolism and fusion regulation. Some terms appear unrelated, but they do not undermine the main mitochondrial lipid/metabolic theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032049","count":1},{"id":"GO:0016042","count":1},{"id":"GO:0010636","count":1},{"id":"GO:0048017","count":1},{"id":"GO:0030719","count":1}]},{"hash":"1899737041831628394","title":"Embryonic development and morphogenesis","description":"The top GO terms span multiple developmental and morphogenetic processes across tissues (heart development, left/right patterning, cartilage morphogenesis, EMT in endocardial cushions, pole cell formation, etc.), rather than a single pathway. This suggests a general developmental cluster rather than a specific process, so a broad label like \u201cEmbryonic development and morphogenesis\u201d best captures the common theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0060972","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060536","count":1},{"id":"GO:0000398","count":1}]},{"hash":"246677106731082964","title":"Insect pigmentation and pheromone signaling","description":"Connection centers on pigmentation pathways (melanin biosynthesis and cuticle pigmentation) and chemical communication (response to pheromone, smell perception, male mating behavior, caste/environmental effects), which together reflect pigment-based traits linked to social/pheromone signaling in insects; other GO terms (proteolysis, glutathione, leukotriene biosynthesis) appear ancillary.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:1901750","count":1},{"id":"GO:0006750","count":1},{"id":"GO:0006751","count":1},{"id":"GO:0006583","count":1}]},{"hash":"467939833051275724","title":"Endoplasmic Reticulum Organization and Nuclear Envelope Assembly","description":"This cluster is dominated by GO terms related to ER dynamics (ER inheritance, ER tubular network organization, ER stress response) and nuclear envelope components (nuclear pore complex assembly, mitotic nuclear membrane reassembly), suggesting a cohesive role in ER organization and nuclear envelope remodeling, with some terms likely incidental (e.g., taste and ABA responses) that do not disrupt the overall ER-centric theme.","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032596","count":1},{"id":"GO:0009737","count":1},{"id":"GO:0050913","count":1},{"id":"GO:0048309","count":1},{"id":"GO:0032581","count":1}]},{"hash":"1856505470146015225","title":"Glycan biosynthesis in developmental processes","description":"Top GO terms cluster around arabinogalactan protein metabolism and glycan biosynthesis, with several development-related terms (imaginal disc-derived leg segmentation, root hair cell development, hypochord development). This suggests a theme where glycosylation and glycan modification influence developmental patterning across species. While the specific proteins are few and drawn from diverse contexts, the shared link appears to be glycan metabolism tied to development.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010405","count":2},{"id":"GO:0036011","count":2},{"id":"GO:0055016","count":2},{"id":"GO:0080147","count":2},{"id":"GO:0016267","count":2}]},{"hash":"699110481899154795","title":"Plant cell wall biosynthesis and pollen exine formation","description":"This cluster centers on plant cell wall-related processes, with terms like cell wall organization, plant-type secondary cell wall biogenesis, glucuronoxylan and arabinan biosynthesis, and pollen exine formation, indicating a cohesive theme around polysaccharide production for cell walls. A few proteoglycan-related terms (animal ECM) appear but do not override the plant-centric pattern. ","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0071555","count":2},{"id":"GO:0010584","count":1},{"id":"GO:0010417","count":1},{"id":"GO:0030204","count":1},{"id":"GO:0009834","count":1}]},{"hash":"1538695797470031948","title":"Mitochondrial respiration and electron transport","description":"The terms point to mitochondrial oxidative phosphorylation, including mitochondrial electron transport (cytochrome c to oxygen), proton transmembrane transport, and respirasome assembly, all of which underpin aerobic respiration and ATP production. Magnesium ion transport may support ATP synthase activity; an ER protein folding term appears as a minor outlier. Overall, the cluster is best described by mitochondrial energy metabolism and respiratory chain function.","confidence":"High","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034975","count":1},{"id":"GO:0015693","count":1},{"id":"GO:0009060","count":1},{"id":"GO:0006123","count":1},{"id":"GO:1902600","count":1}]},{"hash":"1909256829519572122","title":"Unknown","description":"The GO terms are too diverse to tie to a single function: reproduction, hematopoietic homeostasis, vascular morphogenesis, immune differentiation, various cell-type differentiations, and general transcription. There isn\u2019t a coherent shared pathway or role across the proteins, so a specific label can\u2019t be confidently assigned.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007339","count":1},{"id":"GO:0061484","count":1},{"id":"GO:0007620","count":1},{"id":"GO:0001569","count":1},{"id":"GO:0045084","count":1}]},{"hash":"1016130341618392516","title":"ERAD and Ubiquitin Regulation","description":"The GO terms point to protein quality control via ubiquitin and ER-associated degradation (ERAD), including negative regulation of ERAD and ubiquitin-related deubiquitination, which suggests a proteostasis/stress-response focus. Additional terms touch on lipid droplet organization and redox homeostasis, implying a broader link between lipid metabolism, oxidative stress, and protein turnover. A few terms appear obsolete, and the small cluster size makes the signal tentative, but the strongest cohesive theme centers on ERAD/ubiquitin-regulated proteostasis and stress response.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034389","count":1},{"id":"GO:0007253","count":1},{"id":"GO:2000157","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0008219","count":1}]},{"hash":"1265098989156037681","title":"RNA processing and translation initiation","description":"The top GO terms cluster around RNA metabolism and processing (tRNA methylation, mRNA stabilization, spliceosome regulation, small-subunit processome assembly) and components of translation initiation (eIF4F complex assembly). This points to a cohesive theme of RNA maturation coupled with the early stages of protein synthesis.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002940","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0034462","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0000381","count":1}]},{"hash":"911121319424882475","title":"Unknown","description":"The top terms span a wide and eclectic set of processes (transcription elongation regulation, competence for transformation, ATP biosynthesis regulation, autophagy, mitochondrial complex III assembly, protein oligomerization, aging-related processes, DNA repair, and ER polarization) with no single dominant function. This broad, mixed theme makes it unclear what cohesive label to assign, so Unknown with no confidence is most appropriate.","confidence":"","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":2},{"id":"GO:0030420","count":1},{"id":"GO:2001171","count":1},{"id":"GO:0097352","count":1},{"id":"GO:0034551","count":1}]},{"hash":"39670618363007484","title":"Embryonic Organogenesis and Neural Development","description":"These proteins share GO terms centered on broad developmental processes across multiple organs and nervous system differentiation (e.g., AV node development, peripheral nervous system neuron development, pituitary gland development, organ induction, myotome development). The recurring theme is embryonic development and tissue morphogenesis rather than a single pathway, with transcription by RNA polymerase II as a general supporting annotation. Confidence: Medium","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":3},{"id":"GO:0060928","count":3},{"id":"GO:0048935","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0001759","count":3}]},{"hash":"60009222672754504","title":"Autophagy and vacuole/lysosome targeting","description":"The terms coalesce around autophagy and lysosome/vacuole targeting, including autophagosome maturation, reticulophagy, piecemeal microautophagy of the nucleus, and the Cvt pathway, suggesting a cohesive autophagy-focused cluster, with some ancillary apoptosis-related signals.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":2},{"id":"GO:0061709","count":2},{"id":"GO:0070257","count":2},{"id":"GO:0034727","count":2},{"id":"GO:0040024","count":2}]},{"hash":"1045991940987488313","title":"Plant Growth and Telomere Chromatin Regulation","description":"The terms point to plant growth and development controls (ABA response, seed growth, chlorophyll biosynthesis, vegetative growth regulation) alongside chromatin and telomere-associated processes (subtelomeric and rDNA heterochromatin formation, histone deacetylation, shelterin assembly, RNA localization to telomeres). This suggests a theme of growth regulation intertwined with chromatin/telomere dynamics, justifying a label that emphasizes both aspects.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1905615","count":1},{"id":"GO:0070933","count":1},{"id":"GO:0009737","count":1},{"id":"GO:0035390","count":1},{"id":"GO:0009736","count":1}]},{"hash":"2256594018433803238","title":"Fatty acid beta-oxidation and energy metabolism","description":"The cluster\u2019s GO terms point to fatty acid breakdown via beta-oxidation, including peroxisomal (acyl-CoA oxidase) and mitochondrial (acyl-CoA dehydrogenase) pathways, as well as carnitine biosynthesis and metabolism, all signifying lipid catabolism for energy. Starvation response and development terms suggest this pathway is linked to energy mobilization during nutrient scarcity and growth. Prostaglandin metabolism and cardiac differentiation appear as related lipid-signaling and developmental roles but are less central here. Overall, the core theme is lipid utilization and energy production.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904070","count":3},{"id":"GO:0033540","count":3},{"id":"GO:0006693","count":2},{"id":"GO:0045329","count":2},{"id":"GO:0042594","count":2}]},{"hash":"739709889797536204","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000294","count":1},{"id":"GO:0016078","count":1},{"id":"GO:1905267","count":1},{"id":"GO:0034965","count":1},{"id":"GO:0001682","count":1}]},{"hash":"2275775445047053455","title":"Autophagy and organelle turnover","description":"The cluster\u2019s GO terms cluster around autophagy-related processes: autophagosome maturation, reticulophagy, piecemeal microautophagy of the nucleus, and Cvt pathway vesicle targeting. While a few other terms touch on stress or signaling, the dominant pattern is autophagic pathways and selective organelle turnover, justifying a label focused on autophagy.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097352","count":1},{"id":"GO:0061709","count":1},{"id":"GO:0070257","count":1},{"id":"GO:0034727","count":1},{"id":"GO:0040024","count":1}]},{"hash":"1666506144841589396","title":"Unknown","description":"The top terms are highly diverse, spanning nitrogen metabolism (nitrate assimilation, nitric oxide biosynthesis), fungal lipid/sterol pathways (ergosterol and sphingolipid metabolism), general lipid biosynthesis, and several eukaryotic processes (myelin maintenance, sebaceous gland differentiation, spliceosome assembly, mitochondrial inheritance, chromatin regulation). This lack of a single cohesive biological theme suggests the proteins do not share a clear, unified function, so a simple \u201cUnknown\u201d label with no confidence can best reflect the cluster.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0006809","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0006636","count":2}]},{"hash":"1481810465504587314","title":"Diverse membrane transporters","description":"The GO terms are dominated by transport-related activities across membranes and organelles, including lipoprotein, fatty acid import into peroxisomes, glycine betaine, methionine, cobalt ions, oligopeptides, and peptide/export processes; plus a ceramide translocation term. This suggests a cluster of proteins whose shared function is transporting diverse substrates, rather than a single specific cargo. The lone mercury-response term is an outlier but does not override the overall transport theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042953","count":3},{"id":"GO:0015910","count":3},{"id":"GO:0046689","count":3},{"id":"GO:0043213","count":3},{"id":"GO:0031460","count":3}]},{"hash":"2135267286848631687","title":"Unknown","description":"The GO terms for this cluster are highly diverse, spanning calcium signaling (ionomycin), stress and DNA damage responses (ionizing radiation, eIF2 alpha phosphorylation), growth and angiogenesis (PDGF signaling, angiogenesis, developmental growth), and development in multiple tissues (nervous system development, B cell tolerance, imprinting). There is no single unifying function or pathway tying these terms together, so a cohesive, specific label is not evident.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904637","count":1},{"id":"GO:0000186","count":1},{"id":"GO:0071479","count":1},{"id":"GO:0010641","count":1},{"id":"GO:0048638","count":1}]},{"hash":"1109226629182081298","title":"BMP-driven multi-tissue development","description":"The top GO terms share BMP signaling alongside diverse developmental processes across tissues (brain development, odontogenesis, neurogenesis, skeletal muscle development, intestinal stem cell homeostasis, hemopoiesis). This pattern points to proteins involved in BMP-mediated regulation of development in multiple tissues, rather than a single tissue-specific role. The cluster thus seems centered on developmental signaling networks guided by BMP, with some auxiliary processes, yielding a representative label of BMP-driven multi-tissue development.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008101","count":1},{"id":"GO:0070236","count":1},{"id":"GO:0048642","count":1},{"id":"GO:0036335","count":1},{"id":"GO:0022008","count":1}]},{"hash":"1304597108230401962","title":"Antennal and compound eye development transcription regulation","description":"This cluster centers on transcriptional regulation during sensory organ development, highlighted by GO terms for DNA-templated transcription and its regulation, together with antennal and compound eye photoreceptor development. The shared theme is transcriptional control guiding antenna and eye development, suggesting these proteins act as regulators in these processes.","confidence":"High","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":1},{"id":"GO:0007469","count":1},{"id":"GO:0045316","count":1},{"id":"GO:0006355","count":1}]},{"hash":"487181879357597757","title":"Nitric Oxide\u2013driven vascular regulation","description":"The cluster is characterized by GO terms emphasizing nitric oxide biosynthesis regulation, maintenance of vessel diameter, and blood pressure control, indicating NO-mediated vascular tone and cardiovascular signaling as the core function; peripheral themes involve erythrocyte biology and oxidative stress responses, remodeling-related processes, but the central thread is vascular regulation by NO.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045429","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0050880","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0032966","count":2}]},{"hash":"46730577809343720","title":"Mitochondrial oxidative phosphorylation","description":"The top GO terms point to the mitochondrial electron transport chain and ATP production (NADH dehydrogenase activity, NADH to ubiquinone flow, proton motive force\u2013driven ATP synthesis) with related ion translocation, indicating oxidative phosphorylation in mitochondria as the shared function of this cluster.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042773","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0099132","count":1}]},{"hash":"205228243583569012","title":"Dopaminergic signaling and mitochondrial regulation","description":"The top GO terms center on positive regulation of dopaminergic synaptic transmission, indicating neuronal signaling, while several terms point to mitochondrial dynamics and cardiolipin metabolism (stress-induced fusion, cardiolipin regulation). Some immune signaling terms (IL-2 production, T cell polarity) suggest broader signaling roles, but the clearest shared theme is the interplay between neuronal signaling and mitochondrial regulation. Overall, these suggest a cluster focused on signaling with links to mitochondrial function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":3},{"id":"GO:0001302","count":3},{"id":"GO:1900210","count":3},{"id":"GO:1903905","count":3},{"id":"GO:0045541","count":3}]},{"hash":"1426907237010177357","title":"Membrane Ion and Sugar Transport","description":"This cluster is dominated by transmembrane transport GO terms for ions and sugars (nitrate, potassium, selenite, organic cation, glucose, xylose), pointing to a common theme of plasma membrane transport. A couple of terms relate to osmotic stress or epithelial maintenance, but the core signal is transport across membranes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015706","count":1},{"id":"GO:0060731","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0006970","count":1},{"id":"GO:0097080","count":1}]},{"hash":"1839626768976067417","title":"Unknown","description":"The GO terms are spread across developmental, muscular, regulatory, and metabolic processes with no single coherent function linking the proteins, so a clear, specific cluster label cannot be assigned.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033234","count":3},{"id":"GO:0019749","count":3},{"id":"GO:0010842","count":3},{"id":"GO:1905205","count":3},{"id":"GO:0006816","count":3}]},{"hash":"1263744920978062268","title":"Peptidyl-glutamic acid gamma-carboxylation","description":"The only Top Term is peptidyl-glutamic acid carboxylation, indicating gamma-carboxylation of glutamate residues; the cluster likely centers on this post-translational modification, even though no direct interactions are shown among the three proteins.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017187","count":1}]},{"hash":"758052512210299082","title":"Excitatory synapse assembly and plasticity","description":"The top GO terms cluster around excitatory synapse formation, postsynaptic potential regulation, neuron adhesion, and active zone cytoskeletal organization, pointing to proteins involved in building and modulating excitatory synapses and learning-related processes.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051262","count":1},{"id":"GO:1904861","count":1},{"id":"GO:0001919","count":1},{"id":"GO:2000463","count":1},{"id":"GO:0007158","count":1}]},{"hash":"1583377348264572866","title":"Hormone and xenobiotic metabolism","description":"The top GO terms show hormone-related metabolism (androgen, progesterone, vitamin D) and several xenobiotic catabolic/biosynthetic processes (camphor, coumarin, vancomycin), suggesting these proteins participate in metabolizing both endogenous hormones and foreign compounds. Some ion-response and inflammatory terms are present but less cohesive. Therefore, this label best represents the core pattern in the cluster.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0008209","count":2},{"id":"GO:0019383","count":2},{"id":"GO:0010164","count":2},{"id":"GO:0035865","count":2},{"id":"GO:0046226","count":2}]},{"hash":"1421999252342306449","title":"Nematode Embryogenesis and Reproduction","description":"The GO terms point to nematode-specific developmental and reproductive processes, including molting and cuticle formation, pharyngeal pumping, and fertilization-related events (polyspermy prevention, sperm binding regulation) along with embryonic axis specification and morphogenesis. Together these suggest a cluster of proteins involved in nematode development and reproductive biology rather than a general metabolic function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":3},{"id":"GO:0007313","count":3},{"id":"GO:2000360","count":3},{"id":"GO:0060468","count":3},{"id":"GO:0006508","count":3}]}]