{"hash":"2126522209054613160","title":"Protein Quality Control and Folding in ER and Nucleus","description":"The top GO terms cluster around protein homeostasis: ER-based protein folding (GO:0034975), ubiquitin-proteasome\u2013mediated nuclear protein quality control (GO:0071630), and regulation of nuclear export, all pointing to proper protein folding and turnover across compartments. Negative regulation of protein kinase activity (GO:0006469) may reflect modulation of signaling tied to protein activity, supporting a general theme of quality control and regulation rather than a single enzyme pathway. A few terms (DNA replication, parathyroid hormone response) appear less connected and may be noise. Overall, this cluster centers on maintaining proper protein conformation and localization. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"CAG5094393.1","go_terms":[]},{"accession":"CAG5099380.1","go_terms":[]},{"accession":"CAG5106873.1","go_terms":[]},{"accession":"CAG5084504.1","go_terms":["GO:0006452","GO:0090084","GO:0006458","GO:0031204","GO:0006986","GO:0071374","GO:0001707","GO:0070843","GO:1901621","GO:0006260","GO:0070389","GO:0097428","GO:0006469","GO:0032781","GO:0006626","GO:0030433","GO:0009408","GO:0045454","GO:0036494","GO:0051259","GO:1900035","GO:0046825","GO:0035719","GO:0071630","GO:0034975"]},{"accession":"CAG5097702.1","go_terms":["GO:0000294","GO:1905267","GO:0001682","GO:0006364","GO:0006379","GO:0034965"]},{"accession":"CAG5105152.1","go_terms":["GO:0042254","GO:0000028","GO:0000461","GO:0000447","GO:0006412","GO:0006407"]},{"accession":"CAG5085505.1","go_terms":[]},{"accession":"CAG5110540.1","go_terms":["GO:0007165"]},{"accession":"CAG5112435.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0006260":1,"GO:0071630":1,"GO:0090084":1,"GO:0071374":1,"GO:0034975":1,"GO:0046825":1,"GO:0006469":1,"GO:0097428":1,"GO:0006452":1,"GO:1900035":1,"GO:0009408":1,"GO:0006626":1,"GO:0031204":1,"GO:0030433":1,"GO:0036494":1,"GO:0045454":1,"GO:1901621":1,"GO:0051259":1,"GO:0032781":1,"GO:0001707":1,"GO:0006986":1,"GO:0070843":1,"GO:0035719":1,"GO:0006458":1,"GO:0070389":1,"GO:0001682":1,"GO:1905267":1,"GO:0000294":1,"GO:0006379":1,"GO:0006364":1,"GO:0034965":1,"GO:0000028":1,"GO:0000461":1,"GO:0042254":1,"GO:0000447":1,"GO:0006412":1,"GO:0006407":1,"GO:0007165":1},"recipe_readded":["CAG5089262.1","CAG5095709.1","CAG5098338.1","CAG5101473.1","CAG5088984.1","CAG5104951.1","CAG5106724.1","CAG5111915.1","CAG5098472.1","CAG5095727.1","CAG5097438.1","CAG5098160.1","CAG5094564.1","CAG5099171.1","CAG5112461.1","CAG5104505.1","CAG5098164.1","CAG5082909.1","CAG5112564.1","CAG5114046.1"]}