{"hash":"2023567748340430752","title":"Proteasome- and NF-kappaB\u2013mediated immune signaling","description":"The cluster combines genes involved in proteasome function and ubiquitination (proteasome core complex assembly, protein deubiquitination, ubiquitin-independent protein catabolic process) with immune and inflammatory signaling (TNF-mediated signaling, non-canonical NF-kappaB signaling, Fc-epsilon receptor signaling, and negative regulation of inflammatory response). This points to a cohesive module where protein turnover interfaces with inflammatory/immune signaling, with a few secondary associations to Wnt PCP and cell-cycle regulation that are less central. ","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"members":[{"accession":"CAG5099235.1","go_terms":["GO:1990592","GO:0033146"]},{"accession":"CAG5099359.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0006521","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0002862","GO:0010972","GO:0060071","GO:0010499","GO:0016032","GO:0010043","GO:0009651","GO:0043488","GO:0002479","GO:0046686","GO:0010950","GO:0038095","GO:0010363","GO:0016579"]},{"accession":"CAG5100031.1","go_terms":["GO:0090263","GO:0038061","GO:0033209","GO:0010043","GO:0009651","GO:0051437","GO:0051436","GO:0061418","GO:0080129","GO:0043488","GO:0006521","GO:0002479","GO:0046686","GO:0002223","GO:0090090","GO:0050852","GO:0031146","GO:0031145","GO:0060071","GO:0010972","GO:0010950","GO:0002862","GO:0038095","GO:0010363","GO:0016579","GO:0010499","GO:0016032"]}],"graph":[["CAG5099359.1","CAG5099235.1",0.97],["CAG5099359.1","CAG5100031.1",0.955],["CAG5099235.1","CAG5100031.1",0.982]],"all_go_terms":{"GO:1990592":1,"GO:0033146":1,"GO:0002862":2,"GO:0010499":2,"GO:0038095":2,"GO:0010972":2,"GO:0060071":2,"GO:0038061":2,"GO:0033209":2,"GO:0016579":2,"GO:0010950":2,"GO:0080129":2,"GO:0051436":2,"GO:0046686":2,"GO:0043488":2,"GO:0031145":2,"GO:0061418":2,"GO:0002479":2,"GO:0006521":2,"GO:0010043":2,"GO:0010363":2,"GO:0016032":2,"GO:0031146":2,"GO:0002223":2,"GO:0009651":2,"GO:0090090":2,"GO:0090263":2,"GO:0051437":2,"GO:0050852":2},"recipe_readded":[]}