[{"hash":"1245540716782999099","title":"Monoaminergic GPCR Signaling","description":"The top GO terms cluster around GPCR-mediated signaling with monoaminergic inputs (dopamine, octopamine) and downstream effects such as Rho signaling, receptor desensitization, and physiological processes like blood pressure regulation and thermogenesis, tying neuromodulation to metabolic and immune regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0035025","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0051586","count":13}]},{"hash":"1647577750700591628","title":"Cardiovascular signaling and metabolic regulation","description":"Top GO terms suggest a module integrating energy metabolism (electron transport chain, diet-induced thermogenesis) with cardiovascular signaling (blood pressure regulation, heart development, GPCR/cAMP pathways, ERK cascade). While neural/behavioral terms are present, the shared theme appears to be coordination between metabolic energy use and heart-related signaling, justifying a label centered on cardiovascular signaling and metabolism.","confidence":"Medium","size":29,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":19},{"id":"GO:0045777","count":19},{"id":"GO:0010579","count":19},{"id":"GO:0019233","count":19},{"id":"GO:0007190","count":18}]},{"hash":"828294627608738277","title":"Potassium Transport and Temperature/Pain Sensing","description":"The top GO terms show strong enrichment for potassium ion transport and membrane potential regulation (import/export, transmembrane transport, resting potential), alongside sensory-related terms such as perception of pain, temperature stimulus, and mechanosensation. This suggests a cluster of potassium channels/transporters that modulate excitability and contribute to thermosensory and nociceptive signaling, with relevance to cardiac repolarization as well. ","confidence":"High","size":29,"edges":110,"triangles":47,"max_degree":16,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0098914","count":15},{"id":"GO:0050976","count":13}]},{"hash":"1297149311227722633","title":"Neuronal ion transport and synaptic signaling","description":"The cluster is dominated by GO terms related to neuronal signaling and ion transport (calcium and potassium ion movement across membranes, chloride transport, excitatory/inhibitory synaptic activity). Terms like regulation of circadian sleep/wake cycle, startle response, excitatory postsynaptic potential, and gamma-aminobutyric acid receptor clustering point to a theme of neural excitability and synaptic modulation. A couple of items (acrosome reaction, chondrocyte intercalation) are unrelated to the majority, which may reflect multifunctional proteins or broader annotations, but the core signal points to neuronal ion transport and synaptic signaling.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":19},{"id":"GO:0045188","count":19},{"id":"GO:0001964","count":19},{"id":"GO:0071805","count":19},{"id":"GO:0002087","count":19}]},{"hash":"470382692380495664","title":"Cell Division and Cytokinesis Machinery","description":"The top GO terms cluster around mitosis, spindle assembly, and cytokinesis (cell cycle, mitotic spindle midzone, cytokinesis, septum assembly) with supporting links to cell migration and cytoskeletal polymerization, indicating a division/cytokinesis-centered module.","confidence":"High","size":29,"edges":98,"triangles":186,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051301","count":12},{"id":"GO:0051256","count":12},{"id":"GO:0007049","count":12},{"id":"GO:0001764","count":11},{"id":"GO:1903087","count":11}]},{"hash":"8174519019707887","title":"Diverse Metabolic and Translation Processes","description":"These terms span vitamin biosynthesis, multiple sugar and lipid catabolic pathways, and ER organization, along with translation-related activities (mitochondrial translation and tRNA gln transamidation). The cluster appears to gather proteins involved in broad metabolism plus elements of protein synthesis and organelle organization, rather than a single cohesive pathway.","confidence":"Medium","size":29,"edges":6,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":5},{"id":"GO:0032543","count":5},{"id":"GO:0070681","count":4},{"id":"GO:0007029","count":4},{"id":"GO:0009062","count":4}]},{"hash":"89698228474405527","title":"Bone formation and collagen remodeling","description":"The cluster shows strong enrichment for intramembranous ossification, endochondral ossification, and collagen fibril organization/catabolic processes, indicating roles in bone development and extracellular matrix remodeling. While complement activation terms appear, the dominant theme centers on bone formation and ECM/collagen dynamics.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001957","count":18},{"id":"GO:0030574","count":18},{"id":"GO:0001958","count":17},{"id":"GO:0033034","count":17},{"id":"GO:2000534","count":17}]},{"hash":"1282606376269816475","title":"Collagen-Mediated Morphogenesis and Ossification","description":"The cluster is dominated by terms tied to collagen-rich extracellular matrix remodeling during development, including post-embryonic body morphogenesis, cuticle development, collagen fibril organization, and endochondral ossification, plus collagen-activated signaling. This points to a cohesive theme of collagen-driven developmental morphogenesis and skeletal formation, with a few immune-related terms appearing as peripheral noise. ","confidence":"High","size":29,"edges":24,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0040032","count":5},{"id":"GO:0042338","count":5},{"id":"GO:0038063","count":2},{"id":"GO:0045671","count":2},{"id":"GO:0001958","count":1}]},{"hash":"1875705985933866935","title":"Membrane Transporters","description":"The top GO terms point to diverse transmembrane transport activities (ions like Na+ and K+, nitrate/nitrite, arabinose, sialic acid, vitamins, xenobiotics, etc.), indicating a coherent theme of solute movement across membranes. Despite no observed interactions within the cluster, the common function across proteins appears to be membrane transport of various substrates, justifying this label as a representative, specific cluster name.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":8},{"id":"GO:0071805","count":8},{"id":"GO:0006855","count":7},{"id":"GO:0042128","count":7},{"id":"GO:1900754","count":7}]},{"hash":"1663066020674933667","title":"Fungal mating, sporulation, and cell cycle","description":"The top terms include ascospore formation and karyogamy, indicating fungal mating processes, together with mitotic cell cycle, cell division, actin remodeling, and ubiquitin-dependent protein turnover. This points to a cluster of genes involved in fungal reproductive development linked to core cell-cycle regulation. Some terms may reflect broad or cross-species annotations.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":3},{"id":"GO:0051764","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035690","count":2}]},{"hash":"1717669678546804503","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":17,"triangles":0,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006469","count":4},{"id":"GO:0006458","count":3},{"id":"GO:0097428","count":3},{"id":"GO:0036494","count":3},{"id":"GO:0071630","count":3}]},{"hash":"988560427910162876","title":"DNA replication and transcription control with PI3K/Akt signaling","description":"The cluster is enriched for DNA-templated transcription and DNA replication, suggesting strong emphasis on gene expression and genome duplication. Coupled with regulators of the PI3K/AKT pathway and NFAT signaling, plus a term related to glial cell proliferation, the dominant theme appears to be coordinated cell growth and transcriptional regulation, particularly in a neural context. Some immune and stress-response terms are present but seem secondary to the core growth/transcription signals.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051897","count":3},{"id":"GO:0051534","count":3},{"id":"GO:0060252","count":2}]},{"hash":"2257205799440139891","title":"Embryonic organogenesis and morphogenesis","description":"The top GO terms all point to developmental processes across multiple organs (eye, heart, lung, placenta, prostate, habenula) and morphogenetic events, with transcription by RNA polymerase II indicating active gene expression programs during development. This suggests the cluster comprises proteins involved in broad embryonic organ development and morphogenesis rather than a single specific pathway.","confidence":"High","size":29,"edges":77,"triangles":21,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":15},{"id":"GO:0007507","count":13},{"id":"GO:0060441","count":12},{"id":"GO:2000288","count":12},{"id":"GO:0060527","count":12}]},{"hash":"1730238685633652242","title":"Drosophila Tracheal & Imaginal Disc Development","description":"Most of the top GO terms point to developmental morphogenesis and signaling in Drosophila, especially tracheal development (outgrowth and pit formation) and imaginal disc\u2013derived wing expansion, with supporting cues from ERK signaling and receptor internalization regulation. This suggests a coherent theme of developmental signaling programs governing morphogenesis in fruit flies.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":3},{"id":"GO:0002092","count":3},{"id":"GO:0006915","count":2},{"id":"GO:0042331","count":2},{"id":"GO:0045671","count":2}]},{"hash":"1823807755996795156","title":"Immune Signaling and ECM-Cell Interactions","description":"The top GO terms cluster around immune communication and cell-extracellular matrix crosstalk: integrin-mediated signaling, extracellular matrix\u2013cell signaling, T cell receptor signaling, Fc\u03b5 receptor signaling, and antigen processing/presentation via MHC II. This combination points to immune cell activation and regulation with coordinated ECM engagement, rather than a single metabolic pathway. Some terms like mesonephros development or protein autoprocessing are less central annotations present in the set.","confidence":"High","size":29,"edges":13,"triangles":2,"max_degree":5,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0007229","count":9},{"id":"GO:0071226","count":7},{"id":"GO:0035426","count":7},{"id":"GO:0038095","count":6},{"id":"GO:0090263","count":6}]},{"hash":"2122513059652378950","title":"Cerebellar development and Bergmann glia signaling","description":"Top terms strongly point to cerebellar cortex formation and Bergmann glial cell differentiation, suggesting a cerebellum-focused neural development cluster. Additional signals from axon regeneration and MAPK/ERK regulation support neural signaling processes, while some immune and metabolic terms may reflect shared pathways rather than core function. Overall, the dominant theme is cerebellar development with glial involvement.","confidence":"Medium","size":29,"edges":371,"triangles":2826,"max_degree":28,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0021697","count":18},{"id":"GO:0048679","count":18},{"id":"GO:2001275","count":18},{"id":"GO:0008286","count":18},{"id":"GO:0008285","count":18}]},{"hash":"1539338298323085431","title":"Cytoplasmic translation and cell division","description":"The top GO terms are dominated by translation-related processes (translation, translational initiation/termination, cytoplasmic translation) with accompanying cell cycle and division terms (cell division, cell cycle, cell septum assembly). This suggests the cluster reflects core protein synthesis machinery alongside cell replication processes, justifying a combined label of translation and division. Negative regulation of salt stress and antibiotic response appear peripheral to this core theme but do not override it.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006415","count":3},{"id":"GO:0006413","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0051301","count":3}]},{"hash":"82488593674885347","title":"Cell Cycle Progression and MAPK Signaling","description":"This cluster's top GO terms center on cell cycle control (G1/S and G2/M transitions), mitotic spindle dynamics, and transcription, with a prominent p38 MAPK cascade. Additional terms reference proliferative contexts in cartilage and mammary epithelium, and retinoic acid responsiveness, consistent with growth and proliferation regulation. The convergence on cell cycle and MAPK signaling supports a coherent label for this cluster.","confidence":"High","size":29,"edges":242,"triangles":1112,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":22},{"id":"GO:0003430","count":17},{"id":"GO:0090188","count":17},{"id":"GO:0038066","count":17},{"id":"GO:0033598","count":17}]},{"hash":"2296393956016405899","title":"GTPase-Regulated Cell Migration and Proteolysis","description":"The top GO terms center on ubiquitin-dependent protein catabolic process, regulation of GTPase activity, and G protein subunit heterotrimerization, alongside cell migration and extracellular matrix remodeling (substrate-dependent migration, ECM assembly regulation, extravasation, metallopeptidase activity). This points to a coherent module where GTPase signaling and proteolysis coordinate cell movement and tissue invasion. Some plant-specific terms (chlorophyll biosynthesis, stamen formation) appear incidental.","confidence":"High","size":29,"edges":18,"triangles":4,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006511","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0070208","count":4},{"id":"GO:0006929","count":3},{"id":"GO:0015995","count":3}]},{"hash":"1868376396060428727","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0038202","count":2},{"id":"GO:0097711","count":2}]},{"hash":"1079012684544683179","title":"Salt taste perception and osmoregulation","description":"The top GO terms center on sensory perception of salty and sour taste, salt aversion, and water/volume homeostasis, with supporting signals related to pH response and systemic regulation of fluids. This indicates a cohesive theme around gustatory detection of salt and regulation of body water balance, possibly with an insect-specific context given terms about tracheal system clearance. Confidence: Medium","confidence":"","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050891","count":4},{"id":"GO:0003026","count":3},{"id":"GO:0050914","count":3},{"id":"GO:0035002","count":3},{"id":"GO:0050915","count":3}]},{"hash":"1031909848269123871","title":"Retroviral integration and proviral latency","description":"Top GO terms center on DNA integration, viral entry into the host nucleus, proviral latency, DNA recombination, and RNA-templated DNA biosynthesis (reverse transcription). These reflect a retroviral-like life cycle: entry, reverse transcription, genome integration, replication, and establishment of latency. A couple of terms (negative regulation of siRNA processing, regulation of plant-type cellulose biosynthesis) may reflect host pathways that viruses interact with or co-opt, but do not override the dominant retroviral theme.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0075713","count":4}]},{"hash":"1631380591285882743","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0000724","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0000447","count":2}]},{"hash":"1179261700982212803","title":"Ubiquitin-Dependent Protein Degradation","description":"The most represented function in this cluster is ubiquitin-dependent protein catabolic process, with 8 proteins annotated to GO:0042787. While other terms are more diverse (including transcription regulation, mRNA processing, and differentiation signals), ubiquitin-mediated proteolysis is a plausible shared mechanism linking these regulatory processes, especially given links to NF-\u03baB signaling and cell-cycle regulation. The lack of strong, cohesive edges among members suggests a broader regulatory group centered on protein turnover rather than a single tight pathway, so the label is representative but not perfectly uniform across all members.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":8},{"id":"GO:0000083","count":5},{"id":"GO:0070431","count":5},{"id":"GO:0032088","count":5},{"id":"GO:0045444","count":4}]},{"hash":"695138619088319989","title":"Unknown","description":"The GO terms are diverse (apoptosis, epithelial polarity, calcium release, actin bundle assembly, DNA recombination/integration, and left-right patterning) with no clear shared pathway or function. The absence of edges and inclusion of obsolete terms further suggest there isn\u2019t a coherent, single theme for this cluster. Therefore, a confident, unified label cannot be assigned.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0006378","count":2}]},{"hash":"1259824566138703619","title":"Unknown","description":"Unknown","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050772","count":2},{"id":"GO:0043087","count":2},{"id":"GO:0021960","count":2},{"id":"GO:0042753","count":2},{"id":"GO:0006351","count":2}]},{"hash":"560818077652444301","title":"Unknown","description":"The top GO terms are spread across sensory signaling, mitochondrial calcium handling, insulin secretion, protein complex assembly, mitosis, DNA replication, and post-translational modification, with no clear unifying function or strong term overlap. The lack of edges and a coherent shared theme supports labeling this cluster as Unknown.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007606","count":2},{"id":"GO:0051561","count":1},{"id":"GO:0036444","count":1},{"id":"GO:0032024","count":1},{"id":"GO:0035786","count":1}]},{"hash":"480640411217915269","title":"Transmembrane Ion and Substrate Transporters","description":"Dominated by GO terms for transmembrane transport of ions and diverse substrates (sodium, potassium, nitrate, arabinose, 4-hydroxyphenylacetate, vitamins, xenobiotics), this cluster is best described as membrane transporter proteins with broad substrate specificity; a few terms (receptor internalization, gravitropism) are peripheral and do not define the main function.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031623","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0009958","count":2},{"id":"GO:0006855","count":2}]},{"hash":"1824005811288783813","title":"Stimulus-response signaling and ion transport","description":"The cluster centers on signaling and transport in response to stimuli: regulation of GTPase activity for signaling, membrane-associated transport (potassium and amino acid transport), and responses to temperature, pain, and metabolic cues. Together these point to proteins coordinating how cells sense and respond to environmental stimuli via signaling and membrane transport, with a plant-specific term appearing as a potential artifact.","confidence":"Medium","size":28,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0015824","count":3},{"id":"GO:0002024","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0071805","count":2}]},{"hash":"2273559588152829299","title":"ECM remodeling and connective tissue development","description":"The top GO terms point strongly to extracellular matrix\u2013related processes, including collagen fibril organization, collagen-activated signaling, skin development, and endochondral ossification, which together indicate connective tissue development and ECM remodeling. Complement activation terms (classical and lectin pathways) suggest a concurrent immune/torming aspect that can accompany tissue remodeling. A few terms are more peripheral (e.g., voltage-gated sodium channel clustering, renal albumin absorption), but they do not override the central ECM/connective tissue theme.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3},{"id":"GO:0038063","count":3}]},{"hash":"1655148192310376887","title":"Neuronal synaptic signaling and ion transport regulation","description":"This cluster is dominated by GO terms related to neuronal communication and membrane potential control: excitatory postsynaptic potentials, GABA receptor clustering, and regulation of action potentials and chloride transport. Cocaine response and circadian sleep regulation also tie into neural signaling networks. A couple of terms (cellulose catabolic process, acrosome reaction) are likely annotation noise. Overall, the shared theme is synaptic signaling and ion-channel regulation in neurons.","confidence":"Medium","size":28,"edges":17,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0030245","count":2},{"id":"GO:0071493","count":2},{"id":"GO:0007340","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0045188","count":1}]},{"hash":"2241284019935872294","title":"Neuronal synaptic signaling and ion transport","description":"The cluster is dominated by GO terms tied to neural communication: excitatory postsynaptic potentials, GABA signaling, and sodium and potassium ion transmembrane transport, plus conditioned taste aversion as a behavioral readout of neural signaling. Obsolete glycosylation and proteoglycan metabolism terms appear peripheral, but the core theme is synaptic signaling and ion transport in neurons.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0071805","count":2}]},{"hash":"2254661791323839629","title":"Wnt/Hippo Signaling and Apoptosis","description":"This cluster is enriched for top GO terms involving Wnt signaling, Hippo signaling, and apoptosis, indicating a core theme of signaling networks that regulate cell fate, growth, and cell death. Other terms like keratinocyte differentiation and regulation of nuclear export support a broader context of cellular differentiation and signaling, but the strongest, recurrent themes are Wnt/Hippo pathway regulation and apoptosis. ","confidence":"Medium","size":28,"edges":3,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":7},{"id":"GO:0006915","count":7},{"id":"GO:0046827","count":7},{"id":"GO:0046677","count":6},{"id":"GO:0048240","count":6}]},{"hash":"2280613767992173408","title":"Ion and water transport","description":"The majority of GO terms center on transmembrane transport of ions and small molecules (potassium, glycerol) and water, as well as transepithelial water transport and intracellular water homeostasis, indicating a core theme of membrane transport and osmoregulation. A few other terms (nitrate assimilation, insulin response, eye development) appear as ancillary processes but can be related to broader metabolic or developmental contexts in tissues where transport is critical. This supports a label focused on transport and osmoregulation rather than a single specialized pathway.","confidence":"Medium","size":28,"edges":16,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0042128","count":2},{"id":"GO:0032869","count":2},{"id":"GO:0033326","count":2},{"id":"GO:0009992","count":2}]},{"hash":"935238870285852606","title":"Apoptosis and ECM remodeling with immune clearance","description":"This cluster is enriched for apoptotic processes and recognition of apoptotic cells, along with complement pathway activation, suggesting a theme of immune clearance of dying cells. In addition, terms related to collagen fibril organization and endochondral ossification point to extracellular matrix remodeling and bone development. Some terms like aminophospholipid transport and renal albumin absorption hint at membrane and transport processes that can accompany phagocytic and tissue remodeling activities. Overall, the most coherent theme tying these terms together is apoptosis-driven immune recognition and extracellular matrix remodeling.","confidence":"Medium","size":28,"edges":18,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0043654","count":3},{"id":"GO:0015917","count":3},{"id":"GO:0001958","count":2},{"id":"GO:0033034","count":2}]},{"hash":"1355934274819509759","title":"Apoptotic Cell Recognition and Clearance Network","description":"The two most frequent terms are apoptotic process and recognition of apoptotic cell, indicating a core focus on programmed cell death and clearance. Aminophospholipid transport supports exposure of \"eat-me\" signals on dying cells, tying into clearance by phagocytes. The remaining terms (cell signaling, angiogenesis, proteolysis) suggest broader tissue remodeling and signaling contexts that may accompany apoptosis.","confidence":"Medium","size":28,"edges":24,"triangles":4,"max_degree":12,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0006915","count":7},{"id":"GO:0043654","count":7},{"id":"GO:0015917","count":7},{"id":"GO:0045766","count":4},{"id":"GO:0007267","count":3}]},{"hash":"781679621734066533","title":"Axon Guidance in Neural Development","description":"Most of the top GO terms point to neuronal pathfinding and nervous system formation, including semaphorin-plexin signaling for axon guidance, branchiomotor neuron axon guidance, sympathetic neuron projection, trigeminal nerve organization, neural crest migration, and axonal fasciculation. This indicates a cohesive theme around how neurons connect and organize during development. A few terms (single fertilization, molting/cuticle, kidney development) appear as less central background processes but do not override the dominant neural-development signal.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902287","count":3},{"id":"GO:0021785","count":3},{"id":"GO:0097490","count":3},{"id":"GO:0021637","count":3},{"id":"GO:0036486","count":3}]},{"hash":"1013843102145699853","title":"Cell cycle and vesicle trafficking regulation","description":"Top GO terms indicate enrichment for cell division and cell cycle, along with processes tied to intracellular trafficking and protein homeostasis (proteasome regulatory particle assembly, intralumenal vesicle formation, SNARE complex regulation, Golgi protein retention) and calcium signaling. This combination suggests a theme of coordinating cell cycle progression with vesicle trafficking and protein turnover, rather than a single narrow function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0070682","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0007507","count":3},{"id":"GO:0051209","count":3}]},{"hash":"2072987902122230978","title":"Golgi-ER and Endosome Vesicle Trafficking","description":"The top GO terms show a tight focus on intracellular vesicle transport involving the ER-to-Golgi pathway, endosome-to-Golgi and endosome-to-endosome sorting, intra-Golgi transport, and vesicle fusion with the Golgi, plus Golgi ribbon formation. There are also trafficking-related terms linked to delivering neurotransmitter receptors to the postsynaptic membrane and processes underlying synaptic potentiation, suggesting the proteins act in coordinated vesicle trafficking and receptor localization, including synaptic components. This combination points to a cohesive vesicle trafficking and receptor delivery function rather than disparate processes.","confidence":"High","size":28,"edges":31,"triangles":17,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006888","count":15},{"id":"GO:1903078","count":12},{"id":"GO:0045022","count":12},{"id":"GO:0034498","count":12},{"id":"GO:0032258","count":12}]},{"hash":"2028802109422176082","title":"Angiogenesis and vascular development","description":"The Top Terms cluster around endothelial cell behavior (proliferation, migration), smooth muscle proliferation, ECM remodeling (collagen fibril organization), and organ development (kidney, lung), with some cell-cycle regulation signals. This pattern points to vessels forming and remodeling, involving endothelial and smooth muscle components across organs, making the vascular development theme most representative.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030308","count":3},{"id":"GO:0001935","count":2},{"id":"GO:0014912","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0030324","count":2}]},{"hash":"470561751577290174","title":"Cell Cycle and Nuclear Transport Machinery","description":"This cluster centers on core cell cycle processes (cell division, DNA replication, mitotic chromatid separation) and nuclear transport (NLS-dependent protein import, mRNA export), supplemented by vesicle trafficking between ER and Golgi and proteasome assembly. Together these terms suggest a coherent module coordinating division with intracellular transport and protein turnover.","confidence":"High","size":28,"edges":23,"triangles":0,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":10},{"id":"GO:0006607","count":8},{"id":"GO:0043547","count":8},{"id":"GO:0006260","count":7},{"id":"GO:0006888","count":7}]},{"hash":"959137882248766520","title":"Actin Cytoskeleton Remodeling","description":"The cluster is driven by multiple GO terms related to actin filament organization and polymerization, lamellipodium assembly, barbed-end capping, and dendritic spine morphogenesis, pointing to actin cytoskeleton dynamics as the unifying function across the proteins. A minor term about mRNA polyadenylation and Fc receptor signaling appears incidental to the main theme. ","confidence":"High","size":28,"edges":15,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0030838","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0030032","count":2}]},{"hash":"997579643840780255","title":"Transcriptional Regulation and Immune Signaling","description":"This cluster is dominated by DNA-templated transcription and RNA polymerase II\u2013mediated transcription terms, suggesting a core set of transcriptional regulators. It also includes immune-related terms (cytokine production, IL-4 response, MHC class II biosynthesis) indicating coordinated immune signaling. Placental development and vascular healing terms are present but likely reflect broader developmental/vascular roles rather than a single cohesive pathway; overall, the group seems to connect transcriptional control with immune/cytokine responses.","confidence":"Medium","size":28,"edges":253,"triangles":1632,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0006366","count":9},{"id":"GO:0071353","count":8},{"id":"GO:0001892","count":8},{"id":"GO:0045348","count":8}]},{"hash":"431430032092183674","title":"Embryonic morphogenesis and development","description":"Top GO terms indicate roles in embryonic development and tissue morphogenesis (maternal axis specification, fin morphogenesis, prevention of polyspermy, axis formation, axon guidance, sprouting angiogenesis) as well as reproductive and extracellular remodeling processes (cuticle/molting cycle, proteolysis, negative regulation of sperm binding). This mix points to a cluster of proteins involved in developmental patterning and morphogenesis across species, rather than a single tissue-specific function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0048632","count":8},{"id":"GO:0018996","count":7},{"id":"GO:0006508","count":7},{"id":"GO:0007313","count":7},{"id":"GO:2000360","count":7}]},{"hash":"94559866726895759","title":"Ribosome Biogenesis and Translation in Cell Cycle","description":"This cluster\u2019s strongest signals are ribosome biogenesis, translation, and nuclear export of ribosomal subunits, coupled with cell-cycle and mitotic processes, suggesting a coordinated role in protein synthesis during cell division. Some terms like DNA integration and ephrin signaling are less central but present among the proteins.","confidence":"Medium","size":28,"edges":47,"triangles":2,"max_degree":13,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":8},{"id":"GO:0000055","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0015074","count":3},{"id":"GO:0000747","count":3}]},{"hash":"147260680730459774","title":"RNA splicing and miRNA processing machinery","description":"Most terms center on RNA processing, including RNA splicing, spliceosomal tri-snRNP assembly, mRNA processing, and primary miRNA processing, plus regulatory ncRNA-mediated post-transcriptional gene silencing. A few terms hint at RNA interference-based defense, which fits the silencing theme. Overall, the cluster appears to group proteins involved in RNA maturation and silencing rather than unrelated processes.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":2},{"id":"GO:0050829","count":1},{"id":"GO:0033168","count":1},{"id":"GO:0016246","count":1},{"id":"GO:0031053","count":1}]},{"hash":"960172537085057563","title":"Developmental biology and translation initiation","description":"Top GO terms indicate diverse developmental roles (brain development, fertilization, axis specification, molting) alongside translation-related processes (translation reinitiation, formation of translation preinitiation complex). The presence of proteolysis and ubiquitin-dependent ERAD pathway terms suggests remodeling and quality-control during development. Taken together, these proteins likely belong to a cluster involved in developmental programs that require tight regulation of protein synthesis and turnover.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007420","count":3},{"id":"GO:0071456","count":3},{"id":"GO:0007338","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0030433","count":3}]},{"hash":"727870247427016082","title":"Mitotic spindle and chromatin regulation","description":"The top GO terms are centered on the centrosome cycle and spindle assembly, which are core to mitosis, complemented by histone modifications (e.g., H3-K27 methylation, H3-K23 acetylation) indicating chromatin remodeling during cell division. While a few development and apoptotic signaling terms appear, the dominant pattern points to cell division coupled with chromatin regulation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007098","count":3},{"id":"GO:0098532","count":3},{"id":"GO:0051225","count":3},{"id":"GO:0048513","count":2},{"id":"GO:0043972","count":2}]},{"hash":"442646825827588073","title":"Acetylation-driven chromatin modification","description":"GO terms in this cluster cluster around acetylation events (peptidyl-lysine N6-acetylation, N-terminal peptidyl-methionine acetylation) and chromatin regulation (subtelomeric heterochromatin formation, histone H4 acetylation), indicating a cohesive theme of acetylation modifying chromatin structure and gene expression. A few metabolism-related terms (putrescine/spermidine acetylation, glucosamine metabolism) are present but secondary to the chromatin-acetylation pattern.","confidence":"High","size":28,"edges":42,"triangles":23,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0006348","count":9},{"id":"GO:0009447","count":8},{"id":"GO:0032918","count":8},{"id":"GO:0045150","count":8},{"id":"GO:2000025","count":8}]},{"hash":"140512803558211372","title":"Unknown","description":"Unknown","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":2},{"id":"GO:0048008","count":2},{"id":"GO:0051017","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0016477","count":2}]},{"hash":"2232675317904441929","title":"ER stress and secretory pathway vesicle trafficking","description":"The top GO terms cluster around COPII vesicle budding, ER localization, and unfolded protein response, pointing to ER-associated secretory pathway functions. Endocytosis and calcium homeostasis reinforce vesicle trafficking and ER signaling roles, with some host-virus interaction terms suggesting involvement in host modulation of viral processes; overall, the proteins appear tied to ER function and vesicle trafficking, justifying this label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090114","count":4},{"id":"GO:0006897","count":3},{"id":"GO:0044828","count":3},{"id":"GO:0060304","count":3},{"id":"GO:0070972","count":3}]},{"hash":"2135802423881969279","title":"Signaling and Development Pathways","description":"This cluster includes GO terms tied to multiple signaling and differentiation processes (Wnt signaling, NOD2 pathway, oligodendrocyte differentiation, skeletal muscle regeneration, endothelial delamination) along with related cellular activities like cell cycle and protein oligomerization, suggesting a broad theme of signal-driven development and cell fate decisions rather than a single cohesive function.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0050966","count":4},{"id":"GO:0072660","count":3},{"id":"GO:0007253","count":3}]},{"hash":"269947258440405362","title":"DNA transcription and cell cycle regulation","description":"This cluster centers on core regulatory processes: DNA-templated transcription, cell division and proliferation, and protein ubiquitination, indicating a theme of controlling gene expression and cell growth. While some terms touch on signaling, migration, or development (e.g., GPCR signaling, male gonad development), these appear peripheral to the main pattern of transcriptional and cell-cycle regulation. Confidence: Medium","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0007205","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0051301","count":2}]},{"hash":"371069440992559936","title":"Rho-regulated actin remodeling and morphogenesis","description":"This cluster is enriched for GO terms tied to actin-based structures (lamellipodium, filopodium, microspike assembly) and Rho signaling, indicating coordinated actin cytoskeleton remodeling and cell shape changes. While there are also terms related to mitotic spindle assembly and transcription, the dominant theme centers on cytoskeletal dynamics that drive cell morphology.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0090307","count":4},{"id":"GO:0007266","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0008584","count":4},{"id":"GO:0030032","count":3}]},{"hash":"1450096051184304279","title":"Plant cell wall biosynthesis and plasmodesmata organization","description":"The cluster is dominated by plant-specific processes: regulation of plant-type cell wall cellulose biosynthetic process, plant-type cell wall modification involved in multidimensional cell growth, and plasmodesma organization, suggesting a cohesive theme around plant cell wall construction and intercellular connectivity. A few unrelated or obsolete terms appear, but the plant-focused terms provide the main signal.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0006310","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0051123","count":2}]},{"hash":"1128046691769899762","title":"RNA Pol II Transcription Initiation and Elongation","description":"The top GO terms point to transcription by RNA polymerase II, including preinitiation complex assembly and elongation, with regulatory aspects of Pol II elongation. Despite a few obsolete terms, the dominant theme is Pol II-driven transcription initiation and elongation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060303","count":1},{"id":"GO:0010793","count":1},{"id":"GO:0051123","count":1},{"id":"GO:0070827","count":1},{"id":"GO:2001253","count":1}]},{"hash":"1154126763073397105","title":"Unknown","description":"The GO terms in this cluster cover a mix of collagen/ECM organization, collagen signaling, bone development, complement activation, kidney development, DNA integration, and voltage-gated sodium channel clustering. There isn\u2019t a clear, cohesive functional theme tying these terms together, and there\u2019s no network connectivity (edges/triangles) to suggest a specific shared pathway, so a confident single-label name cannot be assigned.","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0001958","count":1},{"id":"GO:0033034","count":1},{"id":"GO:2000534","count":1},{"id":"GO:0038063","count":1}]},{"hash":"635951051460787559","title":"Multisystem stimulus response signaling","description":"This cluster combines terms related to perceiving and responding to various stimuli (pain, temperature, touch, cocaine) across tissues, plus associated signaling processes (ERK cascade, GTPase regulation) and a cardiac development/function element, suggesting a broad stimulus-response signaling theme across multiple organ systems.","confidence":"Medium","size":27,"edges":249,"triangles":1067,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":13},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0007507","count":10},{"id":"GO:0050976","count":9}]},{"hash":"464040936723798014","title":"Collagen-ECM Organization and Skeletal Development","description":"The most represented terms center on collagen fibril organization, cuticle/matrix development, endochondral ossification, and body morphogenesis, pointing to extracellular matrix remodeling and skeletal/connective tissue development. While complement activation terms appear, they likely reflect tissue remodeling contexts rather than defining the core function. Thus a label focusing on collagen-ECM assembly and skeletal development fits the cluster.","confidence":"High","size":27,"edges":19,"triangles":0,"max_degree":19,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0042338","count":20},{"id":"GO:0040032","count":19},{"id":"GO:0001958","count":18},{"id":"GO:0033034","count":18},{"id":"GO:2000534","count":18}]},{"hash":"1320829771083823904","title":"Temperature-Driven Signaling and Membrane Excitability","description":"This cluster features temperature-related GO terms (diet-induced thermogenesis, cellular response to temperature), together with terms tied to membrane potential regulation and cardiac/neuronal excitability (resting potential, membrane stabilization, atrial repolarization), GPCR signaling, and energy metabolism (electron transport chain). The mix points to a theme of temperature-responsive signaling that governs cellular excitability and metabolic state.","confidence":"Medium","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002024","count":12},{"id":"GO:0071502","count":12},{"id":"GO:0019233","count":12},{"id":"GO:0010579","count":8},{"id":"GO:0045777","count":8}]},{"hash":"490407071333668511","title":"Collagen-Driven ECM Signaling in Development","description":"The top terms emphasize collagen-related processes (collagen fibril organization; collagen-activated tyrosine kinase receptor signaling) and protein complex formation, pointing to extracellular matrix (ECM) interactions. These ECM/collagen signals align with developmental processes highlighted here (endochondral ossification, endodermal differentiation) and tissue remodeling events such as metanephric mesenchyme migration; the presence of complement activation terms suggests additional immune modulation during development. Taken together, the cluster appears to reflect collagen/ECM signaling pathways that drive developmental processes, with some ancillary immune context.","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0070208","count":23},{"id":"GO:0035987","count":23},{"id":"GO:0001958","count":22},{"id":"GO:0033034","count":22},{"id":"GO:2000534","count":22}]},{"hash":"1309124246487392956","title":"Collagen-ECM Signaling in Skeletal Development","description":"The top terms cluster around collagen fibril organization, endochondral ossification, and collagen-activated receptor signaling, pointing to extracellular matrix remodeling driving skeletal development. Other terms like eye morphogenesis and complement pathways may reflect broader developmental roles or annotation noise, but the core theme is ECM\u2013mediated development.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3},{"id":"GO:0038063","count":3},{"id":"GO:0001867","count":3}]},{"hash":"266218968597231428","title":"Transmembrane Xenobiotic and Ion Transport","description":"The cluster is dominated by GO terms for transmembrane transport of xenobiotics, vitamins, ions (potassium, phosphate), and trehalose, with related stress and metabolism signals. This pattern points to membrane transporter proteins handling diverse substrates across membranes, forming a cohesive transport module.","confidence":"High","size":27,"edges":70,"triangles":33,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":27},{"id":"GO:0035461","count":27},{"id":"GO:0042908","count":24},{"id":"GO:0071805","count":24},{"id":"GO:0042891","count":17}]},{"hash":"1854922531140361191","title":"Cellular stress signaling and apoptosis","description":"This cluster centers on pathways involved in responding to cellular stress and regulating cell fate, including apoptosis, DNA damage response (ionizing radiation), and growth/proliferation signaling (hippo, integrin, and B cell receptor signaling). The mix with immune-related signaling (neutrophil chemotaxis) and protein quality control hints at coordinated stress responses affecting both survival and immune signaling, making a unifying label of cellular stress signaling and apoptosis appropriate.","confidence":"Medium","size":27,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0035329","count":3},{"id":"GO:0071479","count":2},{"id":"GO:0050853","count":2},{"id":"GO:0007229","count":2}]},{"hash":"845116003146492161","title":"Plant lipid and cell-wall catabolism with defense signaling","description":"Top GO terms indicate strong lipid catabolism (triglyceride, monoacylglycerol, phosphatidylserine) and cell wall polysaccharide breakdown (cellulose, pectin), along with defense-related signaling (salicylic acid pathway, camalexin biosynthesis, GLR signaling). This points to a cohesive theme of energy/resource remodeling and cell wall turnover during plant defense.","confidence":"High","size":27,"edges":12,"triangles":0,"max_degree":12,"top_function":"autophagy","top_go_terms":[{"id":"GO:2000124","count":8},{"id":"GO:0019433","count":8},{"id":"GO:0006660","count":7},{"id":"GO:0052651","count":7},{"id":"GO:0030245","count":6}]},{"hash":"191032994197874339","title":"Unknown","description":"Unknown","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006278","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0015074","count":3},{"id":"GO:0000467","count":2},{"id":"GO:0006281","count":2}]},{"hash":"628979060899433454","title":"Unknown","description":"The terms cover cholesterol biosynthesis, visual learning, T cell differentiation, thalamus development, steroid hormone response, sperm capacitation, kinetochore localization, defense against Gram-positive bacteria, nitric oxide response, and xenophagy. The set spans lipid metabolism, neuroscience, immune function, reproduction, and cell signaling with no clear shared pathway, so a single descriptive label is not supported.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006695","count":6},{"id":"GO:0008542","count":6},{"id":"GO:0046638","count":5},{"id":"GO:0021794","count":4},{"id":"GO:0071383","count":4}]},{"hash":"1132742679693633427","title":"Yeast chromatin remodeling and transcription regulation","description":"The cluster centers on chromatin dynamics and transcription control, with terms covering chromatin assembly during replication, histone H3 acetylation, transcription initiation-coupled remodeling, preinitiation complex assembly, and heterochromatin formation at rDNA and silent mating-type loci. This points to a cohesive role in regulating RNA polymerase II\u2013mediated transcription via chromatin state changes, particularly in yeast contexts and carbon-source\u2013responsive regulation.","confidence":"High","size":27,"edges":195,"triangles":712,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0006335","count":9},{"id":"GO:0043966","count":9},{"id":"GO:0045815","count":9},{"id":"GO:0051290","count":9}]},{"hash":"1248390646079214724","title":"Developmental signaling and differentiation","description":"Top terms indicate enrichment for developmental pathways and differentiation processes, including canonical Wnt signaling, oligodendrocyte and mammary gland development, along with general transcription and ubiquitination that support these programs. The mix suggests a broad theme of developmental signaling and regulation of cell fate rather than a single, narrow function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0016567","count":3},{"id":"GO:2001275","count":3},{"id":"GO:0071260","count":3}]},{"hash":"775142065012896520","title":"Ribosome Biogenesis and ER Unfolded Protein Response","description":"This cluster is dominated by translation-related terms (translation, regulation of translational fidelity, ribosomal large subunit assembly, leucyl-tRNA aminoacylation) and an ER quality-control signal (endoplasmic reticulum unfolded protein response), suggesting proteins involved in protein synthesis and ER-associated protein folding/degradation. The presence of DNA-templated transcription and DNA replication terms is less central but may reflect shared cellular housekeeping roles, not a conflicting main theme.","confidence":"High","size":27,"edges":39,"triangles":4,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006450","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0070389","count":2}]},{"hash":"88123382561773041","title":"Unknown","description":"The GO terms are a mix of neural development (axonogenesis, synaptic potentiation, neurotrophin signaling) and broad developmental processes (heart and bone development) plus immune response and basic cellular regulation, with no single dominant theme connecting them all. This spread makes it unclear to assign a cohesive, specific function to the cluster.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0060291","count":4},{"id":"GO:0007409","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1654508837971645762","title":"Unknown","description":"The top GO terms split into two largely unrelated themes: ribosome biogenesis (LSU/5.8S rRNA maturation) and diverse neural/immune functions (axon guidance, juxtaparanode localization, NK cell activation, dendritic cell differentiation, hypersensitivity, melanocyte adhesion). Because there is no clear shared process, localization, or pathway defining this cluster, it does not map to a single coherent function.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000470","count":1},{"id":"GO:0000466","count":1},{"id":"GO:1902287","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0048378","count":1}]},{"hash":"768791617028561163","title":"T cell activation and dendritic cell differentiation","description":"The top terms are dominated by adaptive immune processes: T cell costimulation (2), regulation of T cell cytokine production (1), and positive regulation of dendritic cell differentiation (1), suggesting a theme of T cell activation and antigen-presenting cell dynamics. Other terms (lactation, cardiac muscle regeneration, xenobiotic response) appear less central and may reflect pleiotropic annotations, but the strongest signals point to immune signaling and cell\u2013cell interactions in the adaptive immune response.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031295","count":2},{"id":"GO:0007595","count":2},{"id":"GO:0061026","count":2},{"id":"GO:2000010","count":2},{"id":"GO:0071333","count":1}]},{"hash":"372913858255502879","title":"Viral Entry and Proviral Latency","description":"The top GO terms cluster around symbiont/viral entry into host cells, viral penetration into the host nucleus, and establishment of integrated proviral latency, with connecting themes of host apoptosis modulation and DNA recombination. While a few terms (e.g., heart development, oxidative stress response) are less directly related, the core signals point to viral infection and genome integration/latency processes as the common theme of this protein cluster.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0042542","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0051291","count":2}]},{"hash":"1746613100385802335","title":"Calcium signaling in muscle and heart","description":"The cluster shows a clear focus on calcium handling and signaling relevant to muscle and cardiac function (mitochondrial Ca2+ regulation, SR Ca2+ release regulation, and electrical coupling in cardiac conduction), which aligns with muscle differentiation and cardiac excitation-contraction processes. Other terms touch on broader cellular trafficking and development, suggesting pleiotropic roles but still centered on Ca2+-mediated signaling in muscle/heart contexts.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0051562","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0010880","count":1},{"id":"GO:1901844","count":1}]},{"hash":"547830848078292920","title":"Vertebrate development and Wnt signaling","description":"The cluster\u2019s top GO terms cluster around vertebrate development and signaling, including corpus callosum development, nephric duct morphogenesis, ectoderm-mesoderm interaction, and the Wnt signaling pathway. While some terms are more peripheral (telomere maintenance, dATP catabolic process, store-operated calcium entry), the core theme is developmental morphogenesis and pathway regulation in vertebrates, suggesting these proteins collectively relate to tissue patterning and signaling during development.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032212","count":2},{"id":"GO:0006929","count":1},{"id":"GO:0022038","count":1},{"id":"GO:1903744","count":1},{"id":"GO:0072178","count":1}]},{"hash":"1089982252942105830","title":"Bacterial cell wall and envelope biosynthesis","description":"Most enriched GO terms point to synthesis of cell envelope components: lipoteichoic acid, peptidoglycan, glycolipids and dolichol-linked oligosaccharides. Additional signals for carbohydrate metabolism and lipid glycosylation support an envelope-focused biosynthetic program, and cell division/shape regulation terms suggest envelope remodeling during division. Overall, the cluster appears to collect proteins involved in building and modifying the Gram-positive cell wall and associated glycans.","confidence":"High","size":27,"edges":54,"triangles":7,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":10},{"id":"GO:0005975","count":7},{"id":"GO:0051301","count":7},{"id":"GO:0009247","count":7},{"id":"GO:0009252","count":7}]},{"hash":"1507103475100072942","title":"Steroid and xenobiotic metabolism","description":"Dominant GO terms indicate xenobiotic detoxification and lipid/steroid biosynthesis pathways (xenobiotic catabolic process, cholesterol and bile acid biosynthesis, cortisol and prostaglandin biosynthesis, omega-hydroxylase P450 pathway). The presence of female gonad development and sex differentiation terms suggests a link to steroid hormone\u2013driven development. Some items (insecticide metabolism, tongue muscle differentiation) are less central but do not contradict the main theme. Overall, a coherent theme around steroid and xenobiotic metabolism with developmental connections.","confidence":"Medium","size":27,"edges":48,"triangles":2,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0042738","count":22},{"id":"GO:0001516","count":22},{"id":"GO:0008585","count":22},{"id":"GO:0007548","count":21},{"id":"GO:0034651","count":21}]},{"hash":"224076860326552513","title":"Embryonic and neural development","description":"This cluster is enriched for embryogenesis and nervous system terms (primitive streak formation, dorsal spinal cord development, midbrain development, peripheral nervous system neuron development, multicellular organism development), with related tissue differentiation (cartilage development, pancreatic cell differentiation) and a regulatory transcription term, suggesting a cohesive theme around early development and neural specification.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0090009","count":6},{"id":"GO:0030901","count":6},{"id":"GO:0048935","count":6},{"id":"GO:0007626","count":5}]},{"hash":"641635133246658720","title":"Glycan biosynthesis and cell-surface remodeling","description":"The top GO terms emphasize glycosylation and glycan biosynthesis (O-linked hydroxyproline glycosylation, poly-N-acetyllactosamine, Lewis a epitope biosynthesis) and arabinogalactan protein metabolism, pointing to glycoprotein/glycan-modifying activities that shape the cell surface. Additional terms relate to epithelial polarity, cell adhesion, and developmental structures, suggesting a common role of these proteins in glycan-mediated cell surface remodeling and tissue morphogenesis across species. Confidence: Medium","confidence":"","size":27,"edges":105,"triangles":107,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042248","count":4},{"id":"GO:0080147","count":4},{"id":"GO:0048354","count":4},{"id":"GO:0010405","count":4},{"id":"GO:0010493","count":4}]},{"hash":"2096168065581379545","title":"Brush border microvilli organization","description":"This cluster\u2019s top GO terms cluster around brush border features: regulation of microvillus length, terminal web assembly, and intestinal glucose absorption, which together point to proteins involved in enterocyte microvilli/brush border organization.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032532","count":2},{"id":"GO:0001951","count":2},{"id":"GO:1902896","count":2},{"id":"GO:1901001","count":1},{"id":"GO:0002181","count":1}]},{"hash":"1394649430123251764","title":"Ubiquitin-Dependent Regulation of Meiosis and Development","description":"The top GO terms point to ubiquitin-mediated protein degradation and ubiquitination, coupled with meiosis-related spindle assembly and oocyte maturation, and broader developmental processes like neural tube initiation. This suggests a cluster centered on ubiquitin-driven regulation of meiosis, spindle dynamics, and early development.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":10},{"id":"GO:0000209","count":6},{"id":"GO:0008285","count":6},{"id":"GO:0046785","count":6},{"id":"GO:0070544","count":6}]},{"hash":"1106865291644462379","title":"NADPH-driven metabolism and central carbon catabolism","description":"The cluster emphasizes redox and energy metabolism: NADPH regeneration and the oxidative pentose phosphate pathway (GO:0009051, GO:0006740) along with multiple catabolic processes (alanine, valine, formate, galactarate) that feed into central metabolism. A ribosome biogenesis term appears but is less central to the core theme, suggesting a metabolic-growth context rather than a single specialized pathway. ","confidence":"Medium","size":27,"edges":26,"triangles":0,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0032776","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0009051","count":1}]},{"hash":"1645698666123313559","title":"Cardiovascular development and endothelial mechanotransduction","description":"The terms point to heart formation and vascular signaling: Notch-related cardioblast proliferation and right atrium morphogenesis, venous endothelial differentiation, and responses to mechanical cues (fluid shear stress, mechanical stimulus). Hormonal responses (estrogen, vitamin D) may modulate this signaling, but the dominant theme is cardiovascular development paired with endothelial mechanotransduction. ","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0033280","count":2},{"id":"GO:0003270","count":2},{"id":"GO:0060843","count":2},{"id":"GO:0003213","count":2}]},{"hash":"256118636162031773","title":"Steroid Hormone Biosynthesis and Fatty Acid Metabolism","description":"The dominant GO terms point to steroid hormone production (testosterone and estrogen biosynthesis, C21-steroid hormone metabolic process) and lipid-related processes (fatty acid elongation). Other terms like retinal metabolism and lung development appear less central, but they may reflect broader metabolic roles or annotation noise. Overall, the core theme is steroidogenesis linked to lipid metabolism.","confidence":"Medium","size":27,"edges":286,"triangles":1654,"max_degree":26,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":27},{"id":"GO:0042574","count":26},{"id":"GO:0071768","count":26},{"id":"GO:0030324","count":26},{"id":"GO:0009710","count":26}]},{"hash":"1437163227205532774","title":"Retroviral Entry, Reverse Transcription, and Integration","description":"This cluster is characterized by GO terms tied to retroviral life-cycle steps: viral entry into the host, reverse transcription (RNA-templated DNA synthesis), genome integration and proviral latency, along with host transcription regulation and suppression of RNA silencing, which collectively indicate retroviral infection processes.","confidence":"High","size":27,"edges":157,"triangles":531,"max_degree":20,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0006310","count":8},{"id":"GO:0006278","count":8},{"id":"GO:0075732","count":7},{"id":"GO:0046718","count":7}]},{"hash":"1280988780208731830","title":"Lectin receptor\u2013mediated innate immune activation","description":"The cluster is dominated by GO terms linked to innate immune signaling and antifungal recognition, including C-type lectin receptor signaling, lectin pathway complement activation, Fc-gamma receptor signaling, basophil activation, and phagocytosis recognition, plus cellular responses to fungal origin and inflammatory mediators. While there are a couple of developmental terms (cartilage condensation, distal tubule morphogenesis), the immune-related terms are predominant, justifying this label.","confidence":"High","size":27,"edges":20,"triangles":2,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":20},{"id":"GO:0001502","count":18},{"id":"GO:0045575","count":16},{"id":"GO:0001867","count":16},{"id":"GO:0038094","count":16}]},{"hash":"513235529519658953","title":"Gene Expression and Cell Cycle Signaling","description":"The top GO terms cluster around core gene expression processes (DNA-templated transcription, mRNA transport, ribosome biogenesis) and cell cycle control (mitotic cell cycle), with several terms pointing to broader signaling regulation (kinase activity, GTPase activity, autophosphorylation). This suggests a coherent theme of transcription/translation machinery linked to cell-cycle progression and its regulation by signaling pathways. Some terms like hypoxia response and pinocytosis regulation may reflect ancillary stress signaling but do not overturn the primary theme.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0051028","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0042254","count":4},{"id":"GO:0006351","count":4}]},{"hash":"915635905173128989","title":"Biosynthesis and metabolism of small molecules","description":"The top GO terms cluster around biosynthetic and metabolic processes for diverse small molecules (antibiotics, biotin, strigolactone, menaquinone, alkaloids, triglycerides, etc.) and related detox/regulatory responses, spanning organisms. Given no interaction edges, the shared theme is broad metabolism/biosynthesis rather than a single pathway, so this label reflects a general functional category.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0017000","count":7},{"id":"GO:0009102","count":6},{"id":"GO:0009636","count":6},{"id":"GO:2000124","count":6},{"id":"GO:0019433","count":6}]},{"hash":"2210183998236205960","title":"Galactose/UDP-galactose Metabolism","description":"The top terms are centered on carbohydrate metabolism, especially galactose and UDP-galactose\u2014galactose catabolic process via UDP-galactose, UDP-galactose biosynthetic process, glucose metabolic process, and related phosphorylation\u2014indicating a cohesive cluster focused on galactose handling and UDP-galactose biosynthesis. A few unrelated terms appear (some obsolete), but the dominant theme supports the galactose/UDP-galactose metabolism function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":1},{"id":"GO:0033501","count":1},{"id":"GO:0052574","count":1},{"id":"GO:0080040","count":1},{"id":"GO:0006006","count":1}]},{"hash":"604870011815975059","title":"Innate immune sensing of bacterial components and inflammation","description":"The cluster\u2019s GO terms cluster around detection of bacterial components (lipopolysaccharide), NOD signaling pathways, and regulation of inflammatory processes, including chemokine and IL-18 production. While one term about corpus callosum development appears, the dominant theme is innate immune sensing and inflammatory signaling in response to bacterial motifs.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":1},{"id":"GO:0070434","count":1},{"id":"GO:0071727","count":1},{"id":"GO:0050729","count":1},{"id":"GO:0035751","count":1}]},{"hash":"1173113470628071134","title":"Neuroinflammatory NOD-like signaling","description":"The cluster\u2019s top GO terms cluster around innate immune activation and inflammatory responses in the brain, including detection of lipopolysaccharide, NOD1/NOD2 signaling, chemokine production, and IL-18 regulation. A corpus callosum development term hints at neural context, but the dominant pattern is neuroinflammatory signaling mediated by NOD-like pathways. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022038","count":3},{"id":"GO:0070434","count":3},{"id":"GO:0071727","count":3},{"id":"GO:0050729","count":3},{"id":"GO:0035751","count":3}]},{"hash":"1726753858895049856","title":"Centrosomal microtubule organization","description":"The top GO terms point to microtubule cytoskeleton processes, including cytoplasmic microtubule organization, microtubule anchoring at the centrosome, and tubulin folding, suggesting a shared theme of centrosome-associated microtubule organization, despite some unrelated terms present.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0007023","count":1},{"id":"GO:0072321","count":1},{"id":"GO:1901026","count":1},{"id":"GO:0031122","count":1}]},{"hash":"398267290859077407","title":"Clathrin-mediated endocytosis and vesicle trafficking","description":"This cluster centers on processes related to endocytosis and vesicle trafficking, including clathrin coat assembly, clathrin-dependent endocytosis, and vesicle cargo loading, with connections to EGFR signaling and cell-substrate junctions, suggesting a cohesive role in endocytic trafficking and its impact on signaling and adhesion. Some terms are less directly related (e.g., developmental imaginal disc term, platelets), but the dominant theme is clathrin-mediated vesicle processing.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0034316","count":1},{"id":"GO:0007475","count":1},{"id":"GO:0048261","count":1},{"id":"GO:0045742","count":1}]},{"hash":"1177213839267359766","title":"Sensory Perception and Chemical Sensing","description":"Top terms are dominated by sensory perception: visual perception and detection of chemical stimuli, with additional chemical sensing terms. While other terms touch on development and epithelial processes, the strongest common thread is sensory perception, suggesting a cluster centered on sensory-related proteins with possible ancillary roles in signaling and structure.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035626","count":1},{"id":"GO:0031032","count":1},{"id":"GO:1904706","count":1},{"id":"GO:0030855","count":1},{"id":"GO:0050765","count":1}]},{"hash":"545230590843253295","title":"Pain-Linked Inflammatory Chemokine Signaling","description":"The Top Terms are dominated by chemokine production (CXCL1, CXCL5, CCL3/MIP-1 alpha) and sensory/pain-related terms, with supporting themes in T cell homeostasis and endothelial remodeling. This points to a cluster centered on inflammatory signaling that modulates nociception and immune communication, rather than a single pristine pathway. The presence of pain and chemokine-related terms provides a coherent, high-level theme, despite some cardiovascular-related terms appearing among the terms.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097497","count":2},{"id":"GO:0098703","count":2},{"id":"GO:0043029","count":2},{"id":"GO:1903759","count":2},{"id":"GO:0098907","count":2}]},{"hash":"1327912509351029144","title":"Wnt and Hippo signaling in development and differentiation","description":"Enriched terms cluster around developmental signaling and differentiation: Wnt canonical signaling, Hippo signaling, keratinocyte differentiation, transcription, and multicellular development. This suggests a cohesive theme of how signaling pathways regulate cell fate and tissue development, with apoptosis and chemotaxis as ancillary processes in tissue remodeling.","confidence":"Medium","size":26,"edges":17,"triangles":1,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006813","count":10},{"id":"GO:0006915","count":10},{"id":"GO:0030216","count":10},{"id":"GO:0060044","count":10},{"id":"GO:0090263","count":10}]},{"hash":"1483832639209023327","title":"RNA processing and genome maintenance","description":"The top GO terms cluster around RNA processing (splicing, snoRNA splicing, transcription elongation, nuclear mRNA surveillance) and DNA-related processes (chromatin assembly, DNA replication, DNA repair), suggesting a cohesive group of proteins involved in RNA maturation and genome maintenance; the embryo development term may reflect context but is not central to the core theme.","confidence":"Medium","size":26,"edges":30,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0071048","count":1},{"id":"GO:0000350","count":1},{"id":"GO:0009560","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0034247","count":1}]},{"hash":"2243170088139506845","title":"RNA processing and translation control","description":"The GO terms cluster around mRNA maturation and splicing (spliceosome-mediated splicing and regulation), polyadenylation, mRNA stability under stress, and translation initiation/reinitiation (preinitiation complex formation). A localization term for oskar mRNA further ties to RNA localization and translational control. Taken together, these proteins likely function in RNA processing and subsequent regulation of translation.","confidence":"High","size":26,"edges":42,"triangles":9,"max_degree":9,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":12},{"id":"GO:0031047","count":11},{"id":"GO:0045292","count":10},{"id":"GO:0048026","count":10},{"id":"GO:1901407","count":9}]},{"hash":"2226326790435267453","title":"Lectin receptor-mediated innate immunity","description":"The GO terms emphasize innate immune sensing of fungal origin, including C-type lectin receptor signaling, basophil activation, lectin pathway complement activation, Fc-gamma receptor signaling, and phagocytosis. This points to a coherent function: coordination of pathogen recognition and uptake via lectin and Fc receptors.","confidence":"High","size":26,"edges":147,"triangles":439,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":13},{"id":"GO:0002223","count":13},{"id":"GO:0045575","count":12},{"id":"GO:0001867","count":12},{"id":"GO:0038094","count":12}]},{"hash":"892209337979432450","title":"Steroid and Lipid Biosynthesis","description":"The cluster\u2019s top GO terms center on biosynthetic and metabolic processes tied to lipids and steroids (fatty acid elongation; C21-steroid hormone metabolism; testosterone biosynthesis). Although the set also includes plant- and microbe-specific biosynthesis terms (retinal metabolism, mycolic acid, tropane alkaloids), the strongest signal is the production and modification of lipid- and steroid-related molecules. This makes \u201cSteroid and Lipid Biosynthesis\u201d a concise, representative label.","confidence":"High","size":26,"edges":8,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0042619","count":6},{"id":"GO:0042574","count":5},{"id":"GO:0071768","count":5},{"id":"GO:0030324","count":5}]},{"hash":"1348292800200867500","title":"Embryonic organogenesis and neural development","description":"The GO terms highlight development across multiple organs (midbrain and forebrain formation, cranial skeleton morphogenesis, pancreas and thyroid development) and neural differentiation. Together they point to a broad embryonic patterning/organogenesis program rather than a single tissue function, with transcriptional regulation as a general regulatory layer. This makes \"Embryonic organogenesis and neural development\" a fitting, concise label.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0030901","count":7},{"id":"GO:0090190","count":7},{"id":"GO:0021905","count":6},{"id":"GO:0003309","count":6}]},{"hash":"2154508158074135529","title":"Viral replication and virion assembly","description":"The top terms point to core viral life cycle processes: DNA integration, virion assembly, and release from the host cell, indicating the proteins cluster around viral replication/assembly steps. While some terms (translation, chromatin organization) relate to general host cell biology, they are secondary to the viral lifecycle terms here.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0019076","count":2},{"id":"GO:0019068","count":2},{"id":"GO:0035551","count":2},{"id":"GO:0034396","count":2}]},{"hash":"2101502665819866053","title":"Unknown","description":"The terms show no common biological function; they span development, immune signaling, microbial metabolism, photosynthesis, and flagellar assembly, with no shared pathway or cellular context among the proteins. Because of this dispersion and lack of connectivity (edges 0), a coherent label cannot be assigned beyond Unknown.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0038095","count":2},{"id":"GO:0019385","count":1},{"id":"GO:0044780","count":1}]},{"hash":"743439498984133722","title":"Regulated signaling and cytoskeletal dynamics","description":"The cluster centers on signaling modulation (GTPase activity, kinase activity regulation) and growth/differentiation signals (positive regulation of cell proliferation, Schwann cell development), with supporting roles in cytoskeletal organization (actin patch assembly), mRNA transport, hypoxia response, and calcium-related signaling in muscle. This suggests a cohesive theme of coordinated signal transduction, cytoskeletal remodeling, and cell fate/growth processes across neural and muscular contexts.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008284","count":6},{"id":"GO:0006919","count":6},{"id":"GO:0000147","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0043065","count":4}]},{"hash":"1314681104164482671","title":"Wnt and Hippo Signaling in Development","description":"The top GO terms cluster around signaling pathways (positive regulation of canonical Wnt signaling; Hippo signaling) and developmental processes (keratinocyte differentiation; embryonic cranial skeleton morphogenesis), with additional emphasis on cell-cycle regulation and DNA replication (centrosome cycle; DNA replication; transcription). This suggests a group of proteins coordinating growth, differentiation, and proliferation during development, with apoptosis indicating balance between survival and cell death. ","confidence":"Medium","size":26,"edges":115,"triangles":189,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006915","count":12},{"id":"GO:0030216","count":12},{"id":"GO:0060044","count":12},{"id":"GO:0090263","count":12},{"id":"GO:0035329","count":12}]},{"hash":"2138418308558560923","title":"RNA Processing and Transcription","description":"The cluster is enriched for nuclear gene expression processes: DNA-templated transcription, mRNA splicing, and mRNA transport, indicating RNA production/processing regulation. Some terms (DNA integration, proviral latency, histone modification) point to genome regulation, while a couple neuronal terms may reflect tissue context rather than core function. Overall, the dominant theme is RNA processing and transcription.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0000398","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0050966","count":2}]},{"hash":"2210449218582850707","title":"Receptor signaling and cytoskeletal remodeling in angiogenesis","description":"This cluster centers on receptor-mediated signaling (ephrin and T cell receptor pathways) and cytoskeleton-associated processes (actin reorganization, focal adhesion, serine phosphorylation with downstream ERK and PI3K/AKT signaling), connected to angiogenesis and axon guidance. The GO terms collectively point to signal transduction that tightly links external cues to cytoskeletal dynamics and cell movement, covering both vascular and neural development contexts.","confidence":"High","size":26,"edges":5,"triangles":0,"max_degree":5,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0031532","count":22},{"id":"GO:0048013","count":21},{"id":"GO:0050771","count":21},{"id":"GO:0051893","count":21},{"id":"GO:0033138","count":21}]},{"hash":"2145187431649918617","title":"Nicotinate/Nicotinamide and Nucleotide Metabolism","description":"The cluster is dominated by GO terms tied to NAD-related metabolism (nicotinate nucleotide salvage, nicotinamide metabolic process) and nucleotide/nucleobase catabolism (uracil, creatinine catabolic processes), with supporting signals from spermidine biosynthesis and nitrogen utilization. This points to a cohesive theme around NAD biosynthesis and nucleotide/base metabolism, making the label representative of the cluster\u2019s core function. ","confidence":"High","size":26,"edges":154,"triangles":373,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0019358","count":7},{"id":"GO:0006602","count":5},{"id":"GO:0006212","count":5},{"id":"GO:0002047","count":5},{"id":"GO:0019740","count":5}]},{"hash":"1731774373109716485","title":"DNA damage response and ubiquitin signaling","description":"The cluster is enriched for DNA-templated transcription, DNA replication, UV-damage excision repair, and multiple ubiquitin-related processes (ERAD, ubiquitination, and protein catabolism) as well as PARylation. These terms point to a functional theme around genome maintenance and protein quality control via ubiquitin pathways, with related roles in transcription/replication; other terms like mechanosensory pain detection and homooligomerization are less central. Overall, a cohesive label is DNA damage response and ubiquitin signaling.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0051260","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0070914","count":3}]},{"hash":"204272003651682798","title":"Migration-related signaling and cytoskeletal regulation","description":"This cluster centers on GO terms linking signaling control (GTPase activity, kinase activity regulation, GPCR pathways) with cytoskeletal dynamics (actin bundle assembly, cell migration, polarity). The combination suggests a theme of signaling-driven cytoskeletal rearrangements that enable cell movement, with supporting roles in mRNA transport and stress responses. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":4},{"id":"GO:0048265","count":3},{"id":"GO:0071901","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0051017","count":3}]},{"hash":"972582141354121541","title":"Mitochondrial translation control and RNA localization","description":"The cluster features GO terms centered on mitochondrial gene expression, including negative regulation of mitochondrial translation, assembly of the complex IV respiratory chain, and export of mitochondrial rRNA, indicating a core mitochondrial RNA metabolism theme. Additional RNA-related terms appear, such as oskar mRNA localization and regulation of poly(A) tail shortening, suggesting RNA processing/localization roles. A few outliers (sensory perception of sound, mitotic chromosome condensation) exist, but the dominant signals point to mitochondrial RNA handling and related processes.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0070130","count":1},{"id":"GO:0033617","count":1},{"id":"GO:0000335","count":1},{"id":"GO:0010738","count":1}]},{"hash":"1067922348210781869","title":"Retroviral DNA integration and latency","description":"Top GO terms center on DNA integration, reverse transcription, DNA replication and recombination, and proviral latency, all characteristic of the retroviral life cycle. The presence of viral entry and host apoptosis activation terms further supports a viral infection/integration theme. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":9},{"id":"GO:0046718","count":8},{"id":"GO:0075713","count":8},{"id":"GO:0075732","count":7},{"id":"GO:0039651","count":7}]},{"hash":"2113312510443942199","title":"Plant development and RNA silencing regulation","description":"The terms cluster around plant development and gene-regulation mechanisms: gametophyte and meristem development (megasporocyte differentiation, pole cell formation, shoot apical meristem maintenance, vegetative phase change) alongside post-transcriptional and post-translational control (poly(A) tail shortening, ubiquitination, siRNA-mediated gene silencing), indicating a coherent theme of developmental regulation tied to RNA- and ubiquitin-mediated control.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060903","count":3},{"id":"GO:0016567","count":2},{"id":"GO:0000335","count":2},{"id":"GO:0007279","count":2},{"id":"GO:0060213","count":2}]},{"hash":"11095351022190377","title":"Retroviral entry, integration, and latency","description":"The GO terms point to retroviral life cycle steps: entry into host cell and nucleus, reverse transcription (RNA-templated DNA synthesis), DNA integration into the host genome, recombination and DNA replication, and establishment of proviral latency. Additional terms about RNA interference suppression by viruses and filopodium assembly reflect virus\u2013host interactions and cytoskeletal changes during entry. The combination of these functions strongly suggests a cluster centered on retroviral infection, genome integration, and latency.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0039651","count":3},{"id":"GO:0075713","count":3}]},{"hash":"1549970740962339642","title":"Chromatin remodeling and transcription regulation","description":"The cluster is dominated by nuclear processes: chromatin remodeling (GO:0006338), regulation of DNA-templated transcription, and DNA repair (GO:0006281), with supporting hints from histone modification remnants and development-related terms. This suggests a cohesive theme of chromatin dynamics governing gene expression and genome maintenance, despite some older/related terms and disparate development-related hints.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":3},{"id":"GO:0042993","count":2},{"id":"GO:0006309","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0043486","count":1}]},{"hash":"1643557986117684268","title":"NOD-like receptor\u2013mediated inflammatory signaling","description":"The terms consistently point to innate immune sensing and inflammation: positive regulation of inflammatory response, regulation of chemokine production, IL-18 production, detection of LPS, and positive regulation of NOD1/2 signaling pathways, indicating a cluster focused on bacterial-component sensing and inflammatory signaling. A single term about corpus callosum development is an outlier; overall the pattern supports an innate immune/inflammatory function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":1},{"id":"GO:0070434","count":1},{"id":"GO:0071727","count":1},{"id":"GO:0050729","count":1},{"id":"GO:0035751","count":1}]},{"hash":"1803464736321721190","title":"Viral entry, integration, and proviral latency","description":"This cluster centers on viral processes: entries into host cells and nuclei, DNA integration, DNA replication, and especially proviral latency\u2014collectively pointing to viral infection and provirus maintenance. The presence of symbiont entry and host apoptotic activation terms supports a broader host-pathogen interaction theme, but the core signal is viral entry and genome integration with latency. ","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0006260","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2}]},{"hash":"1359564266107691865","title":"Neuronal signaling and brain development","description":"This cluster is dominated by GO terms tied to neural communication and brain development, notably dopamine uptake in synaptic transmission and chemical synaptic transmission, along with brain development. While metabolism-related terms appear, the recurrent neural function terms strongly suggest a cluster centered on neuronal signaling and neural development.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0051583","count":2},{"id":"GO:0015824","count":2},{"id":"GO:0009088","count":2},{"id":"GO:0019509","count":2}]},{"hash":"1534510367447935276","title":"Embryonic tissue morphogenesis","description":"These proteins share GO terms across diverse morphogenesis processes\u2014face, epidermis, lens placode, skeletal/joint morphogenesis, chondrocyte differentiation in bone morphogenesis\u2014and migration in brain tissue, with involvement of developmental signaling (Wnt, Hippo). The common theme is embryonic tissue morphogenesis and coordinated developmental patterning, rather than a single tissue-specific function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0035332","count":1},{"id":"GO:0001553","count":1},{"id":"GO:0010761","count":1},{"id":"GO:0001743","count":1}]},{"hash":"462194129471643185","title":"Neuronal synapse assembly and axon guidance","description":"The top GO terms point strongly to synapse formation and dopaminergic neuron axon guidance, with supportive enrichment for cell adhesion and extracellular matrix organization, suggesting a theme of neuronal connectivity development and ECM-mediated adhesion.","confidence":"High","size":25,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":8},{"id":"GO:0030199","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0071372","count":5},{"id":"GO:0034446","count":5}]},{"hash":"2180736295628428854","title":"Neural development and synaptic signaling","description":"Top GO terms cluster around neural development and neural function: embryonic cranial skeleton morphogenesis, multicellular organism development, Schwann cell development, visual perception, excitatory postsynaptic potential, long-term potentiation, and Wnt signaling, all pointing to brain development and synaptic activity. Some items (ABA signaling, G2/M transition) are less central or cross-domain, but the core signal is neural development and synaptic signaling.","confidence":"Medium","size":25,"edges":160,"triangles":567,"max_degree":21,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048701","count":7},{"id":"GO:0007275","count":7},{"id":"GO:0007601","count":6},{"id":"GO:0060079","count":6},{"id":"GO:0014044","count":6}]},{"hash":"1072390499059030740","title":"Potassium Ion Transport and Membrane Potential Regulation","description":"The dominant GO terms point to potassium ion transport, intracellular potassium homeostasis, regulation and stabilization of membrane potential, and related membrane repolarization processes, which together define a potassium-channel/ion-transport theme influencing membrane potential. Although a few terms touch on sensory mechanosensation and cardiac/neural development, the core of the cluster appears to be potassium-mediated membrane potential control and ion homeostasis.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060075","count":2},{"id":"GO:0098914","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0030007","count":2}]},{"hash":"268423731038688827","title":"Craniofacial and sensory nervous system development","description":"This cluster centers on developmental processes of craniofacial structures (skin development, face morphogenesis) and nervous system regions (cerebellar molecular layer development) together with sensory functions (mechanical touch detection, pain behavior). While there are a few immune or signaling terms present, the dominant pattern ties to craniofacial/nervous system development and mechanosensory perception. ","confidence":"Medium","size":25,"edges":22,"triangles":1,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0071230","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0002724","count":1},{"id":"GO:0034465","count":1}]},{"hash":"1438001247270015738","title":"Ion transport and neuronal signaling cluster","description":"This cluster is dominated by ion transport terms (K+, Na+, Ca2+, Cl\u2212) and neural signaling processes (EPSP, GABA receptor clustering), with accompanying behavioral terms (startle, circadian regulation) that fit neuronal circuit function. A couple of outlier terms (acrosome reaction, cartilage morphogenesis) can arise from shared signaling/calcium dynamics, but the core theme is ion transport linked to neuronal signaling. ","confidence":"High","size":25,"edges":16,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":15},{"id":"GO:0098703","count":14},{"id":"GO:0045188","count":14},{"id":"GO:0001964","count":14},{"id":"GO:0035725","count":13}]},{"hash":"342045906783724039","title":"Heart and Face Morphogenesis Signaling","description":"The top GO terms center on developmental morphogenesis (heart and face) with linked signaling activities (calcium release, phosphorylation) and proliferation control, indicating a cohesive developmental signaling cluster rather than a single pathway.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060325","count":7},{"id":"GO:0007507","count":6},{"id":"GO:0051281","count":6},{"id":"GO:0007601","count":6},{"id":"GO:0006469","count":6}]},{"hash":"1444873331215536762","title":"Amino acid and small-molecule membrane transport","description":"The cluster\u2019s top GO terms are largely about transport across membranes for amino acids and related small molecules (L-arginine import, D-alanine and D-serine transport, GABA transport, transepithelial ammonium transport, leucine import), with one outlier term for regulatory ncRNA-mediated gene silencing. This pattern suggests a group of proteins whose function centers on transporting amino acids and related metabolites, rather than a single metabolic or signaling role.","confidence":"Medium","size":25,"edges":89,"triangles":104,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0015812","count":1},{"id":"GO:0006527","count":1},{"id":"GO:0097638","count":1},{"id":"GO:0035826","count":1}]},{"hash":"119147564768233973","title":"Dendritic spine actin remodeling","description":"The top GO terms cluster around actin cytoskeleton organization, dendritic spine morphogenesis, lamellipodium assembly, and Arp2/3-mediated actin nucleation, indicating actin-driven remodeling underlying neuronal spine formation and related cell motility. While some terms touch on broader morphogenesis, the cohesive signal is actin dynamics in spines and motility, justifying this label.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0090103","count":2},{"id":"GO:0045636","count":2},{"id":"GO:2000601","count":2}]},{"hash":"2016777578401870055","title":"Muscle contraction and sarcomere organization","description":"The proteins show strong representation of GO terms tied to muscle contraction (skeletal and cardiac), sarcomere organization, and regulation of ATP-dependent activity, including references to fast/slow fiber transitions and cardiac muscle morphogenesis, pointing to a cohesive module of muscle-fiber function and structure.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":1},{"id":"GO:0045932","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0031444","count":1},{"id":"GO:0043057","count":1}]},{"hash":"245768907188661762","title":"Ribosome Biogenesis and rRNA Maturation","description":"Dominant GO terms center on ribosomal large subunit biogenesis, rRNA maturation, and preribosome assembly, with translation represented as well; the core ribosome/RNA processing terms support a ribosome-related cluster, while a few non-specific terms likely reflect noise or multifunctionality.","confidence":"High","size":25,"edges":5,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042273","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0031047","count":3},{"id":"GO:0000466","count":3},{"id":"GO:1902626","count":3}]},{"hash":"803830647394964474","title":"RNA splicing and ribosome biogenesis","description":"The cluster shows enrichment for spliceosomal-related terms (spliceosome assembly, mRNA splicing via spliceosome, mRNA splicing) and ribosome biogenesis, with additional RNA turnover terms (miRNA catabolic process). Although some viral-host interaction terms appear, the dominant theme is RNA metabolism and ribosome assembly, suggesting these proteins are involved in RNA processing and ribosome biogenesis rather than a single viral process.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":3},{"id":"GO:0006378","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0019076","count":2}]},{"hash":"905541274720570444","title":"Central Carbon Metabolism and NADP Redox","description":"The cluster is dominated by GO terms for malate and pyruvate metabolism, plus regulation of NADP metabolism, indicating a core central carbon metabolism with redox regulation. Additional terms like protein tetramerization and cell division suggest general growth-related processes, while some terms (transcription antitermination, obsolete aging/oxidation-reduction) may be noise or outdated annotations. Thus the label captures the main functional theme of metabolism and redox balance.","confidence":"Medium","size":25,"edges":4,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0031564","count":3},{"id":"GO:0007568","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0043464","count":3}]},{"hash":"241025714377447517","title":"Muscle contraction regulation and sarcomere organization","description":"The top GO terms cluster around regulation of muscle contraction, sarcomere organization, and processes like muscle filament sliding, with connections to fast/slow fiber transitions and cardiac muscle morphogenesis. This points to proteins that coordinate contraction mechanics and sarcomere structure across muscle types, justifying a label focused on contraction regulation and sarcomere organization.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014883","count":2},{"id":"GO:0045932","count":2},{"id":"GO:0032781","count":2},{"id":"GO:0031444","count":2},{"id":"GO:0043057","count":2}]},{"hash":"2042997170937412044","title":"Unknown","description":"The top GO terms cover a mix of immune processing, digestion, kidney/renin-angiotensin regulation, development, and other cellular processes without a unifying biological theme or network connectivity, making it unclear how these proteins function together as a coherent cluster.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0016540","count":4},{"id":"GO:0019886","count":4},{"id":"GO:0002803","count":4},{"id":"GO:0001823","count":4}]},{"hash":"1700833600706976464","title":"Embryonic Organ Morphogenesis","description":"This cluster centers on developmental and morphogenetic processes across multiple organs (heart, brain, eye, pituitary, placenta, prostate) during embryogenesis, with additional links to transcriptional regulation and myoblast proliferation, suggesting a broad organogenesis program rather than a single pathway.","confidence":"High","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":9},{"id":"GO:0003148","count":7},{"id":"GO:0000122","count":7},{"id":"GO:0048048","count":6},{"id":"GO:0007507","count":6}]},{"hash":"1923506779933326884","title":"Ubiquitin-mediated mitotic regulation","description":"The top GO terms emphasize cell division, mitotic cell cycle, APC-dependent protein degradation, and K11-linked ubiquitination, indicating a cohesive role in ubiquitin-proteasome\u2013driven control of mitosis. The presence of polyubiquitination and ERAD-related terms supports a broader proteostasis function linked to cell-cycle progression. While a cadmium response term appears, the dominant signal centers on ubiquitin-dependent regulation during cell division, justifying the label.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0031145","count":4},{"id":"GO:0070979","count":4}]},{"hash":"1775592499512809125","title":"Calcium-Driven Neuronal Signaling and Excitability","description":"This cluster is dominated by GO terms tied to calcium entry and calcium-dependent neural signaling (calcium import across the plasma membrane, EPSPs, GABA receptor clustering, and action potential regulation with chloride transport). Additional terms point to circadian regulation by the nervous system and calcium-dependent exocytosis in the acrosome reaction, with a few non-neural entries likely incidental. Overall, the proteins seem to function in calcium-dependent neuronal signaling and excitability.","confidence":"Medium","size":25,"edges":29,"triangles":2,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":12},{"id":"GO:0002087","count":11},{"id":"GO:0007340","count":10},{"id":"GO:0060079","count":10},{"id":"GO:0045188","count":10}]},{"hash":"1351631554956225968","title":"Protein processing and secretory trafficking","description":"Top GO terms show strong representation of proteolysis and protein catabolic processes, including proteolysis, protein autoprocessing, and general protein turnover, together with components of the secretory pathway (COPII-coated vesicle budding, Golgi organization, and vesicle docking in exocytosis). This pattern suggests a functional cluster centered on maturation and trafficking of proteins through the secretory pathway. Some terms (brain development, subtelomeric heterochromatin formation) are less directly linked and may reflect broader or multi-functional proteins in the group, but the dominant signal points to secretory/protein-processing roles.","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":2,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0030163","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0006348","count":3},{"id":"GO:0006904","count":3}]},{"hash":"475758019779531988","title":"Diverse Metabolic Biosynthesis and Catabolism","description":"The GO terms show a mix of biosynthetic (menaquinone, biotin, antibiotic biosynthesis) and catabolic processes (triglyceride, monoacylglycerol, phosphatidylserine, cellulose), plus lipid signaling and detoxification themes. The cluster has no interactions (edges/triangles), suggesting a collection of proteins with varied metabolic roles rather than a single pathway. This label reflects the broad metabolic emphasis across biosynthesis and catabolism without implying a specific pathway. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":7},{"id":"GO:2000124","count":7},{"id":"GO:0006660","count":7},{"id":"GO:0052651","count":7},{"id":"GO:0019433","count":7}]},{"hash":"1457634494627961415","title":"Nuclear transport and meiotic cell cycle with TOR signaling","description":"The top GO terms center on nuclear transport processes (NLS-bearing import, mRNA transport), meiotic cell cycle regulation (meiotic sister chromatid cohesion, oocyte maturation), and TOR pathway signaling (TORC1 signaling, amino acid response). Additional terms about GTPase regulation and serine dephosphorylation, plus ciliary docking, support a theme of coordinated cell-cycle and growth signaling in nucleus-associated contexts. Overall, these components suggest a cluster of proteins involved in nuclear transport and meiosis with TOR-mediated growth signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051754","count":5},{"id":"GO:0051028","count":4},{"id":"GO:0070262","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0038202","count":4}]},{"hash":"1893154414683998642","title":"Osteoclast differentiation and bone matrix remodeling","description":"The cluster prominently features GO terms for osteoclast differentiation, extracellular matrix disassembly, and proteolysis, which together point to bone resorption processes. Additional terms on receptor internalization, cellular response to lipopolysaccharide, and cAMP signaling fit into the signaling and endocytic pathways that regulate osteoclast activity and matrix remodeling.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032496","count":5},{"id":"GO:0042135","count":5},{"id":"GO:0022617","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0055114","count":4}]},{"hash":"1183287919135752774","title":"Diverse Metabolite Biosynthesis","description":"This cluster shows enrichment for multiple biosynthetic processes across different molecule classes (amines like histamine and dopamine, taurine, sphingolipids, phytoalexins, pigmentation), plus related cellular responses and differentiation signals. The terms point to a broad set of metabolic pathways rather than a single, cohesive function, suggesting a label that captures overall metabolic versatility. ","confidence":"Medium","size":25,"edges":252,"triangles":1400,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0048085","count":10},{"id":"GO:0052314","count":10},{"id":"GO:0042136","count":10},{"id":"GO:0001694","count":10},{"id":"GO:0006665","count":10}]},{"hash":"331367851270377868","title":"DNA replication and cell cycle processes","description":"The top GO terms cluster around DNA replication, cell cycle, and DNA repair, suggesting a core association with genome maintenance. Additional terms on mRNA stability regulation and xenobiotic response hint at broader gene expression control and stress responses that accompany these nuclear processes; a lung development term is present but less representative of the dominant DNA metabolism theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030324","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0006260","count":3},{"id":"GO:0007049","count":2},{"id":"GO:0010950","count":2}]},{"hash":"69902166387047856","title":"Developmental Signaling and Tissue Remodeling","description":"The terms point to morphogenesis and tissue regeneration (face morphogenesis, skeletal muscle tissue regeneration, endothelial delamination) combined with key signaling pathways (Wnt, NOD2) and calcium/vitamin D responses, indicating a cohesive theme of developmental signaling guiding tissue formation and remodeling, especially in muscle and vascular contexts, with supportive localization and cell cycle terms.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":3},{"id":"GO:0072660","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0007253","count":3},{"id":"GO:0043403","count":3}]},{"hash":"481282302855069966","title":"Neural and cardiac apoptosis signaling and development","description":"This cluster centers on apoptotic processes in heart and neural/glial cells, with regulatory signals (e.g., positive regulation of apoptotic signaling and TGF-beta responsiveness) and ties to brain development and multicellular development, suggesting a coherent theme of apoptosis regulation within neural and cardiac developmental contexts.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010659","count":2},{"id":"GO:1902510","count":2},{"id":"GO:0007584","count":2},{"id":"GO:0007568","count":2},{"id":"GO:2001235","count":2}]},{"hash":"2143220063528381171","title":"Viral integration and transposon activity","description":"Top GO terms center on DNA integration, DNA transposition, retrotransposition, and proviral latency, plus viral entry into host nucleus. This points to mobilome elements (DNA transposons and retroelements) and proviruses rather than standard metabolic pathways, explaining a coherent label of viral-integrative and transposon activity.","confidence":"High","size":25,"edges":23,"triangles":0,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":5},{"id":"GO:0075732","count":4},{"id":"GO:0046718","count":4},{"id":"GO:0039651","count":4},{"id":"GO:0075713","count":4}]},{"hash":"1158767513018818755","title":"Translation initiation and ribosome assembly","description":"The cluster is dominated by GO terms related to translation initiation and ribosome function (formation of translation preinitiation complex, regulation of translation, IRES-dependent initiation, translation reinitiation, ribosome disassembly, and maintenance of translational fidelity), indicating a cohesive focus on the protein synthesis machinery. A few terms about RNA polymerase and tubulin assembly appear but are less representative of the core theme.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990145","count":1},{"id":"GO:0001731","count":1},{"id":"GO:0032790","count":1},{"id":"GO:0006417","count":1},{"id":"GO:0002192","count":1}]},{"hash":"1804486451398106866","title":"Potassium Transport and Membrane Potential Regulation","description":"The top GO terms cluster around potassium ion transport and multiple aspects of membrane potential control (resting potential regulation, hyperpolarization, repolarization, intracellular K+ homeostasis), suggesting proteins involved in potassium channels or their regulation that shape cellular electrical properties. Minor terms about skin and multicellular development are present but secondary.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050976","count":11},{"id":"GO:0098914","count":11},{"id":"GO:0071805","count":11},{"id":"GO:0060075","count":10},{"id":"GO:0030322","count":10}]},{"hash":"520056068946475884","title":"Potassium Ion Transport and Membrane Potential Maintenance","description":"These proteins predominantly relate to potassium handling and electrical excitability, as shown by GO terms for regulation of resting membrane potential, potassium ion transport, intracellular potassium homeostasis, and stabilization of membrane potential (also cardiac repolarization). While there are some secondary annotations to touch sensation and cerebellar development, the core theme is maintaining membrane potential via potassium dynamics, justifying this label.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060075","count":11},{"id":"GO:0098914","count":11},{"id":"GO:0050976","count":11},{"id":"GO:0071805","count":11},{"id":"GO:0030007","count":11}]},{"hash":"2113680541957477944","title":"Basement membrane and extracellular matrix organization","description":"This cluster is dominated by GO terms for cell adhesion, collagen fibril organization, integrin biosynthesis, and basement membrane/tendon development, pointing to a cohesive group of ECM components and adhesion mediators (basement membrane proteins, collagens, integrins) that mediate cell\u2013matrix and cell\u2013cell adhesion, with some links to paranodal junctions. The complement activation term appears less directly connected and may reflect occasional cross-talk with ECM-associated processes.","confidence":"High","size":24,"edges":77,"triangles":85,"max_degree":14,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":5},{"id":"GO:0030199","count":4},{"id":"GO:0006958","count":4},{"id":"GO:0045162","count":4},{"id":"GO:0035987","count":4}]},{"hash":"601009774286896675","title":"Mucosal Innate Immunity and Inflammation","description":"This cluster is driven by innate immune functions in mucosal tissues, with GO terms highlighting TNF production regulation, neutrophil chemotaxis, TLR4 signaling, and respiratory burst, plus an innate mucosa-specific term. A few terms (olfactory detection and triglyceride transport) appear peripheral and may reflect annotation noise, but the core theme centers on inflammatory innate immune signaling. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032720","count":2},{"id":"GO:0090023","count":2},{"id":"GO:0050907","count":2},{"id":"GO:0042048","count":2},{"id":"GO:0042535","count":1}]},{"hash":"597348335677125667","title":"Zinc Transport and Homeostasis","description":"The dominant GO terms in this cluster center on zinc handling, including zinc ion import across the membrane, intracellular zinc ion homeostasis, and detoxification of zinc ion, pointing to a shared function in zinc transport and homeostasis. Other terms related to membrane transport and related cellular processes may be ancillary or context-specific annotations, but zinc-related terms are the clear common theme. Confidence: Medium","confidence":"","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":2},{"id":"GO:1902476","count":2},{"id":"GO:0016540","count":2},{"id":"GO:0045454","count":1},{"id":"GO:0017004","count":1}]},{"hash":"507524863673033326","title":"Proteolysis and Immune Defense","description":"The cluster shows strong representation of immune-related GO terms (complement activation pathways, antigen processing and presentation via MHC II, antibacterial peptide production, systemic acquired resistance) alongside proteolysis-related processes (digestion, collagen catabolic process, protein autoprocessing). While some development terms appear, the common theme appears to be proteolytic activity linked to immune defense and tissue remodeling, supporting a cohesive label around proteolysis-driven immunity. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":4},{"id":"GO:0007586","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0030574","count":2}]},{"hash":"312327611060071153","title":"Growth and morphogenesis signaling","description":"The terms cohere around signals and processes that shape the cell and regulate growth, including actin cytoskeleton reorganization, Rho signaling, cell spreading, and various morphogenetic growth processes (budding/pseudohyphal growth; cartilage condensation; insulin signaling). The mix also includes broader growth-response pathways such as collagen-activated receptor signaling and nitric oxide response, suggesting a general theme of cell growth and morphogenesis signaling rather than a single precise function.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000251","count":3},{"id":"GO:0038063","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0007121","count":2},{"id":"GO:0035023","count":2}]},{"hash":"2156917769291349868","title":"Ubiquitin-Proteasome\u2013Mediated Protein Degradation","description":"Top GO terms are dominated by ubiquitin-dependent protein catabolic processes and K48-linked ubiquitination, pointing to proteasome-driven protein turnover as the core function of this cluster. Some outlier terms (lipoteichoic acid biosynthesis, angiogenesis, leaf formation) likely reflect annotation spillover rather than a shared function. Overall, the cluster is best described by ubiquitin-proteasome\u2013mediated degradation.","confidence":"Medium","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0070395","count":4},{"id":"GO:0001525","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0042787","count":4}]},{"hash":"1877435117222499366","title":"Ribosome biogenesis and translation","description":"The top terms are dominated by translation and ribosome biogenesis (translation, ribosomal large subunit assembly), indicating a cluster centered on ribosome production and protein synthesis. Secondary terms reference proteostasis regulation and energy metabolism, but the primary signal is ribosomal machinery and translation.","confidence":"High","size":24,"edges":174,"triangles":839,"max_degree":19,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":14},{"id":"GO:0042254","count":5},{"id":"GO:0006123","count":3},{"id":"GO:0009060","count":3},{"id":"GO:0000027","count":3}]},{"hash":"1192730378322331285","title":"Rho-Driven Actin Cytoskeleton Remodeling","description":"This cluster is strongly enriched for GO terms related to actin cytoskeleton dynamics and regulation by Rho GTPases, including regulation of Rho signaling, positive regulation of GTPase activity, Arp2/3-mediated actin nucleation, lamellipodium formation, dendritic spine morphogenesis, and actin filament organization/movement, indicating a cohesive theme of actin remodeling and protrusive structure formation. A minor outlier term about melanin biosynthesis appears unrelated to the core theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0043547","count":3},{"id":"GO:2000601","count":2},{"id":"GO:0072673","count":2},{"id":"GO:0060997","count":2}]},{"hash":"2065201095623744793","title":"Neuronal light/heat stress response and transport","description":"The cluster\u2019s top GO terms center on responses to environmental and hormonal stress (estradiol, high light, UV-A, heat) and activation of the stress-activated MAPK cascade, combined with transport processes, notably anterograde axonal protein transport and negative regulation of intracellular transport. This points to a coherent theme where neurons coordinate stress signaling with cargo movement, rather than a purely structural role. ","confidence":"High","size":24,"edges":271,"triangles":1924,"max_degree":23,"top_function":null,"top_go_terms":[{"id":"GO:0032355","count":15},{"id":"GO:0009644","count":15},{"id":"GO:0070141","count":15},{"id":"GO:0007568","count":15},{"id":"GO:0099641","count":15}]},{"hash":"1547331305175314332","title":"ER-Golgi vesicle trafficking and cell cycle","description":"This cluster is dominated by GO terms for vesicle transport between the ER and Golgi and from Golgi to the plasma membrane, i.e., components of the secretory pathway. There are also several cell cycle and mitotic terms, suggesting a link to cell division and growth, which often requires ribosome biogenesis. Some terms touch on neuronal development (dendrite/axonogenesis) but the strongest coherent theme is ER-Golgi trafficking with cell cycle involvement.","confidence":"Medium","size":24,"edges":13,"triangles":0,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0006888","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0016358","count":3},{"id":"GO:0000278","count":3}]},{"hash":"531905164331941280","title":"Unknown","description":"The top GO terms are a mixed bag, spanning behavioral processes (adult locomotory behavior, suckling, mating) alongside cellular processes (mitotic spindle assembly, mitotic cell cycle, polyadenylation) and ion/calcium homeostasis, with no clear single function uniting them. The absence of edges and a cohesive network further supports the idea that these proteins do not form a single, well-defined module, so a singular, interpretable label is not evident.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006378","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0051402","count":1},{"id":"GO:0051563","count":1}]},{"hash":"1390348981231375237","title":"Dopamine/Octopamine GPCR-cAMP Signaling","description":"The cluster\u2019s GO terms cluster around GPCR-mediated signaling involving dopamine and octopamine/tyramine pathways, including adenylate cyclase-activating dopamine receptor signaling and regulation of PKA activity, as well as dopamine uptake modulation. This points to a neuromodulatory signaling theme driven by cAMP downstream of GPCRs. A few terms relate to immune response or development, but the core pattern is dopaminergic/octopaminergic GPCR signaling, so the label emphasizes the main functional axis.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006955","count":2},{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1},{"id":"GO:0031649","count":1}]},{"hash":"1685681314969196182","title":"Ribosome Biogenesis and Translation","description":"The cluster is enriched for ribosome-related processes: ribosome biogenesis, rRNA maturation, small subunit assembly, translation, and even mitochondrial translation, suggesting a cohesive role in ribosome assembly and protein synthesis; a couple of outliers (chromatin regulation, antibiotic response) are less central.","confidence":"High","size":24,"edges":189,"triangles":852,"max_degree":23,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":13},{"id":"GO:0042254","count":7},{"id":"GO:0000462","count":5},{"id":"GO:0006407","count":4},{"id":"GO:0032790","count":4}]},{"hash":"1976251214607791135","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0060325","count":2},{"id":"GO:0070493","count":2},{"id":"GO:0003376","count":2}]},{"hash":"411907500250177178","title":"Embryonic morphogenesis and signaling","description":"The GO terms cluster around tissue morphogenesis across multiple embryonic contexts (eye, skin, heart, axial mesoderm) and ossification, with supporting signaling pathways (Wnt regulation, JNK activity) and neural axon fasciculation, pointing to developmental patterning and tissue formation as the unifying theme. A few immune/metabolic terms are present but do not override the main developmental signal. High","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048593","count":3},{"id":"GO:0043589","count":3},{"id":"GO:0071230","count":3},{"id":"GO:0001957","count":3},{"id":"GO:0035414","count":2}]},{"hash":"205821844346202854","title":"DNA Replication and Neural Morphogenesis","description":"This cluster shows strong enrichment for DNA replication, mitotic cell cycle, transcription, and DNA repair, pointing to core DNA metabolism. It also includes neural development signals like ephrin signaling, dendrite morphogenesis, and excitatory postsynaptic potential, suggesting some genes connect DNA maintenance with neural development. The name captures both the dominant DNA-related functions and the neural morphogenesis elements observed.","confidence":"Medium","size":24,"edges":43,"triangles":16,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":21},{"id":"GO:0000278","count":18},{"id":"GO:0048701","count":18},{"id":"GO:0006351","count":18},{"id":"GO:0006281","count":18}]},{"hash":"1752480412909296682","title":"Unknown","description":"The top GO terms are highly diverse (neuronal dopamine uptake regulation, cell division, spindle-kinetochore regulation, androgen signaling, epidermis morphogenesis, reticulophagy, actin cable assembly, Golgi docking, Robo signaling, podosome assembly), with no clear shared function or pathway. The cluster has no edges or interactions (Max Degree 0), suggesting the proteins do not form a coherent functional module in this dataset, so a specific cohesive label cannot be assigned.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0051988","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0048730","count":1}]},{"hash":"1264289444819396061","title":"Synaptic organization and ubiquitin-mediated turnover","description":"The presence of GO terms for neuroligin clustering and postsynaptic membrane assembly, plus synaptic vesicle clustering, points to a synaptic organization theme; concurrent ubiquitin-dependent protein catabolism suggests turnover of synaptic proteins, supporting a label focused on synaptic architecture and protein degradation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000146","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0048339","count":1},{"id":"GO:0043162","count":1},{"id":"GO:0010768","count":1}]},{"hash":"2214999636800884086","title":"Oxidative Stress\u2013Related Proteostasis","description":"The cluster centers on oxidative stress responses, chaperone-assisted protein complex assembly, and protein catabolic processes, with additional signals for peroxisomal protein import and mitochondrial DNA replication regulation. This points to a cohesive theme of maintaining protein homeostasis under cellular stress and coordinating quality control across organelles.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0070407","count":2},{"id":"GO:0051131","count":2}]},{"hash":"381758307400360760","title":"Nematode Embryogenesis and Cuticle Molting","description":"The GO terms cluster around embryonic axis specification, multicellular development, nematode cuticle molting, and cadherin-mediated cell adhesion, indicating a shared role in nematode embryogenesis and cuticle formation.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"wound healing","top_go_terms":[{"id":"GO:0048632","count":8},{"id":"GO:0006508","count":8},{"id":"GO:0018996","count":7},{"id":"GO:0007313","count":7},{"id":"GO:2000360","count":7}]},{"hash":"2049025263705861544","title":"Nucleotide salvage and isoprenoid biosynthesis","description":"This cluster prominently features nucleotide salvage processes (CMP, UMP, CTP salvage) alongside isoprenoid/terpenoid biosynthesis pathways (monoterpene, geranylgeranyl diphosphate, cholesterol, CoA biosynthesis) and RNA repair, suggesting a broader metabolic role centered on salvage and lipid/terpenoid metabolism. The connections are plausible but not tightly interconnected, leading to a moderate level of confidence.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":5},{"id":"GO:0044211","count":4},{"id":"GO:0044206","count":4},{"id":"GO:0015937","count":4},{"id":"GO:0006695","count":4}]},{"hash":"471348832159517316","title":"ECM remodeling and vascular mechanotransduction","description":"The prominent terms\u2014collagen fibril organization and blood coagulation\u2014point to extracellular matrix (ECM) and vascular biology. Terms like cellular response to mechanical stimulus and negative regulation of endothelial cell migration reinforce a mechanotransduction and vascular remodeling theme, with kidney development supporting a broader tissue remodeling context. A few terms (e.g., olfactory learning) are less connected but do not override the main ECM/vascular signal. Overall, the cluster centers on ECM organization and vascular/mechanical signaling rather than a single narrow process.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0007596","count":3},{"id":"GO:0008355","count":2},{"id":"GO:0001822","count":2},{"id":"GO:0001921","count":2}]},{"hash":"1643095185645882164","title":"Unknown","description":"The top GO terms span very different biology (nematode molting and pharyngeal pumping; oligodendrocyte differentiation; Wnt and GPCR signaling; NF-kappaB sequestration; cell cycle; muscle regeneration), with no clear, single functional theme connecting all proteins. The lack of interconnecting edges and reliance on older/obsolete terms further suggest no cohesive cluster function. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0048709","count":2},{"id":"GO:0007205","count":2},{"id":"GO:0072660","count":1}]},{"hash":"86732094036932593","title":"Cardiac GPCR signaling and contraction regulation","description":"The cluster shows enrichment for cardiac muscle contraction and heart development alongside multiple GPCR-related terms (tachykinin and acetylcholine receptor signaling, GPCR internalization/desensitization, GTPase activity), indicating a cohesive theme of GPCR-driven signaling that modulates heart function and muscle contraction. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045988","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0007217","count":2},{"id":"GO:0031914","count":2},{"id":"GO:0007507","count":2}]},{"hash":"2032311981008467169","title":"GPCR-Mediated Second Messenger Signaling","description":"The GO terms point to GPCR signaling pathways, including adenylate cyclase activation and adenosine receptor signaling, as well as receptor guanylyl cyclase signaling and blue light signaling, all funneling through intracellular signal transduction. The forskolin\u2013response term reinforces involvement of cAMP as a downstream messenger, with broader links to transcription regulation and other signaling events. Collectively, the cluster appears to comprise proteins involved in GPCR-driven second-messenger signaling (cAMP/cGMP) and related sensory/transduction processes.","confidence":"High","size":24,"edges":19,"triangles":2,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0052565","count":18},{"id":"GO:0071880","count":18},{"id":"GO:0035556","count":18},{"id":"GO:0001973","count":18},{"id":"GO:1904322","count":18}]},{"hash":"1995677635608285124","title":"Cardiac muscle contraction and calcium signaling","description":"Top GO terms center on heart development and regulation of cardiac muscle contraction via sequestered calcium release, calcium handling, and actin cytoskeleton organization, suggesting a cohesive focus on cardiomyocyte contraction and structure. While a few terms appear peripheral (antibiotic response, grooming behavior, COPII trafficking), the dominant pattern aligns with cardiac function and calcium-dependent excitation-contraction coupling.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0010881","count":2},{"id":"GO:0090110","count":2},{"id":"GO:2000821","count":2}]},{"hash":"460464161734793361","title":"Neuropeptide Pain Signaling and Inflammation","description":"The top GO terms are dominated by sensory perception of pain, neuropeptide signaling, and inflammatory response, reinforced by signaling cascade activities (IP3 biosynthesis, ERK cascade) and adenylate cyclase activation, pointing to a coherent theme of neuropeptide-driven signaling in pain and inflammation. Some development-related terms appear but do not define the cluster\u2019s core function; the primary signal transduction and inflammatory-related terms provide the strongest, most representative pattern. Confidence: Medium","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0007218","count":5},{"id":"GO:0006954","count":5},{"id":"GO:0032962","count":5},{"id":"GO:0070374","count":5}]},{"hash":"1494889009954733201","title":"Mitotic cell cycle and translation control in muscle cells","description":"This cluster centers on cell proliferation and division (mitotic cell cycle, cell division, APC-dependent catabolic process) and protein turnover via ubiquitination, alongside translation initiation/reinitiation features. The presence of skeletal muscle differentiation suggests a muscle lineage context, so a label highlighting both mitotic cycle dynamics and translation regulation in muscle-related cells is most representative.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0000278","count":2}]},{"hash":"9380390838685593","title":"Kallikrein-kinin\u2013driven vascular regulation","description":"The top GO terms center on proteolysis and vascular biology (plasma kallikrein-kinin cascade, angiogenesis in wound healing, regulation of endothelial cell migration), indicating a theme of proteolytic control of blood vessel function. Additional terms touch on metabolism and mitochondria distribution, but the vascular/regulatory signals are the strongest motif, suggesting a focus on proteolytic regulation of vascular processes with metabolic context.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0060055","count":1},{"id":"GO:0043535","count":1},{"id":"GO:0002353","count":1},{"id":"GO:0042593","count":1}]},{"hash":"2213931170364359916","title":"Mitotic Cell Cycle Machinery","description":"The top GO terms are dominated by cell division, mitotic cell cycle, and general cell cycle categories, plus protein heterooligomerization, pointing to a cluster enriched in core mitotic machinery and assembly of protein complexes required for cell division. Although some terms touch on reproductive differentiation and other processes, they seem ancillary to the central theme of mitosis and cell-cycle regulation.","confidence":"High","size":23,"edges":3,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0051291","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0046661","count":5}]},{"hash":"885469202362599814","title":"Unknown","description":"The top terms span proton transport, proteasome localization, nuclear import, plant/symbiont interaction responses, cell cycle and heart-rate/conduction regulation, and various developmental processes (root development, papilla formation). This diversity lacks a single cohesive theme, making a concise, representative label difficult. ","confidence":"","size":23,"edges":247,"triangles":1652,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0015991","count":12},{"id":"GO:0031144","count":9},{"id":"GO:0006607","count":9},{"id":"GO:0080034","count":9},{"id":"GO:0007050","count":9}]},{"hash":"2183665185143871307","title":"Cellular stress response and mitochondrial quality control","description":"This cluster centers on responses to xenobiotic stress and cocaine, combined with mitochondrial dynamics (mitophagy and regulation of mitochondrial fusion) and ER-Golgi trafficking, indicating a cohesive theme of cellular stress response and organelle quality control (mitochondria/ER). ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:2000010","count":2},{"id":"GO:0032516","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0035690","count":2}]},{"hash":"1329695292909502011","title":"Unknown","description":"The top terms are scattered across distinct developmental and cellular processes, including face morphogenesis, ductus arteriosus/heart muscle differentiation, and even an enterobacterial antigen biosynthetic process, with only a few mild links to cardiac/muscle development. The lack of a single, cohesive functional theme makes a confident, specific label inappropriate.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0009246","count":2},{"id":"GO:0031204","count":1},{"id":"GO:0006620","count":1},{"id":"GO:0003257","count":1}]},{"hash":"2227411475633616430","title":"Neuronal Fatty Acid Biosynthesis and Protein Assembly","description":"This cluster centers on fatty acid biosynthesis terms (short/medium chain, elongation) and brain-related processes (brain development, neuron apoptotic process), suggesting a neural context for lipid metabolism. The presence of protein complex formation terms (protein homooligomerization/heterotrimerization) supports a role in assembling protein complexes associated with metabolic pathways in neurons. Some terms are less coherent (antibiotic biosynthesis, obsolete responses), but the dominant signal points to neural lipid metabolism with supporting protein assembly.","confidence":"Medium","size":23,"edges":209,"triangles":1049,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":5},{"id":"GO:0051260","count":5},{"id":"GO:0051792","count":4},{"id":"GO:0051790","count":4},{"id":"GO:0019367","count":4}]},{"hash":"1895250173113053127","title":"Unknown","description":"Unknown","confidence":"","size":23,"edges":10,"triangles":0,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000472","count":3},{"id":"GO:0000480","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0021750","count":2}]},{"hash":"409926049184561569","title":"RNA transcription and translation initiation machinery","description":"Dominant terms center on initiation of gene expression, including translation reinitiation, formation of the translation preinitiation complex, and RNA polymerase III preinitiation complex assembly, with supportive signals from mRNA splicing. A few terms touch on stem cell maintenance or viral interactions, but the core theme is RNA synthesis/processing and translation initiation machinery.","confidence":"Medium","size":23,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035019","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0070898","count":2},{"id":"GO:0019076","count":1}]},{"hash":"293572379420056064","title":"Actin cytoskeleton remodeling and cell motility","description":"This cluster is dominated by GO terms related to actin dynamics\u2014crosslinking, polymerization, branching, and effects on cell polarity and shape\u2014and processes tied to cell movement (podosome assembly, actin-driven motility). While a few terms touch on other processes, the shared theme is actin cytoskeleton organization underpinning cellular movement and morphology.","confidence":"High","size":23,"edges":245,"triangles":1616,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":1},{"id":"GO:0051764","count":1},{"id":"GO:0070667","count":1},{"id":"GO:0032911","count":1},{"id":"GO:2000821","count":1}]},{"hash":"957325388943527756","title":"Redox Balance and Xenobiotic Response","description":"The cluster shows strong enrichment for redox homeostasis and responses to xenobiotic compounds (including fungicide exposure), with supporting links to folate metabolism and signaling. This points to a cohesive module centered on oxidative stress management and detoxification, rather than disparate processes.","confidence":"Medium","size":23,"edges":151,"triangles":502,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0008283","count":8},{"id":"GO:0071320","count":8},{"id":"GO:0045454","count":8},{"id":"GO:0046653","count":7}]},{"hash":"1641970793350772018","title":"Immune signaling and actin remodeling","description":"The Top Terms show immune-related regulatory processes (positive regulation of NK cell cytotoxicity, T-helper 2 differentiation) together with cytoskeletal dynamics (lamellipodium assembly), supported by signaling pathways (regulation of phosphatidylinositol dephosphorylation, Ras signaling). This pattern suggests a cluster of proteins coordinating immune signaling with actin-based motility/remodeling, despite a few outlier terms likely due to annotation noise.","confidence":"High","size":23,"edges":22,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0060304","count":2},{"id":"GO:0030032","count":2},{"id":"GO:0002943","count":1},{"id":"GO:0055114","count":1},{"id":"GO:0045630","count":1}]},{"hash":"1366959260919976510","title":"Splicing and RNA Decay Regulators","description":"The cluster is dominated by RNA processing terms\u2014spliceosomal snRNP assembly, regulation of RNA splicing, and mRNA decay pathways\u2014suggesting a set of proteins involved in splicing and post-transcriptional control. Some immune/development terms appear, but the main signal is RNA processing.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":2},{"id":"GO:0060325","count":2},{"id":"GO:1900153","count":1},{"id":"GO:0033120","count":1},{"id":"GO:0031086","count":1}]},{"hash":"1357354206217450491","title":"Amino acid catabolism and quinone/antibiotic biosynthesis","description":"The cluster is enriched for catabolic processes of multiple amino acids (L-alanine, L-kynurenine, L-valine), fatty acid beta-oxidation, and for biosynthesis of quinones (menaquinone, phylloquinone) as well as antibiotic biosynthesis, suggesting a bacterial metabolic/secondary metabolism program rather than a single signaling pathway. The presence of Notch signaling likely reflects annotation noise.","confidence":"Medium","size":23,"edges":253,"triangles":1771,"max_degree":22,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0042853","count":8},{"id":"GO:0007219","count":8},{"id":"GO:0097053","count":8},{"id":"GO:0006107","count":6}]},{"hash":"1251482453945384936","title":"Ribosome biogenesis and cell cycle progression","description":"The top GO terms cluster around ribosome biogenesis (including small subunit), DNA replication, and mitotic processes such as sister chromatid cohesion, plus regulation of G0 to G1 transition and proliferation. This points to a group of proteins involved in core growth and division machinery required for DNA synthesis and protein synthesis during cell proliferation. Developmental terms may reflect overlap with rapidly dividing cells, but the central theme remains ribosome production and cell cycle control. ","confidence":"High","size":23,"edges":188,"triangles":797,"max_degree":22,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0032922","count":2}]},{"hash":"602551947343310840","title":"Mitochondrial Energy Metabolism and Lipid Biosynthesis","description":"This cluster features mitochondrial respiration (NADH to ubiquinone and complex II assembly) and common lipid pathways (cholesterol biosynthesis, cholesterol homeostasis, sphingolipid metabolism). Translation and some differentiation terms are present but less central, so the dominant theme appears to be energy production coupled with lipid biosynthesis and membrane-related processes.","confidence":"Medium","size":23,"edges":63,"triangles":68,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0034553","count":1},{"id":"GO:0021522","count":1},{"id":"GO:0006665","count":1}]},{"hash":"1979383317087587329","title":"Developmental Transcription and Neural Differentiation","description":"These proteins are enriched for DNA-templated transcription and broad developmental processes, including Schwann cell and heart development, multicellular organism development, and neural-related functions like visual perception and synaptic potentiation. The common theme is transcriptional regulation guiding development across neural and other tissues, with neural activity components, supporting a label around developmental transcription and neural differentiation.","confidence":"High","size":23,"edges":7,"triangles":0,"max_degree":5,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":19},{"id":"GO:0046826","count":19},{"id":"GO:0014044","count":17},{"id":"GO:0007507","count":17},{"id":"GO:0007601","count":17}]},{"hash":"531343290250013325","title":"Viral entry and proviral latency","description":"The cluster is centered on functions tied to viral infection: entry of viral material into the host nucleus, integration of viral DNA into the host genome, DNA replication and recombination, and establishment of proviral latency. Negative regulation of siRNA processing aligns with viral strategies to counter host RNA silencing. An outlier term about plant cell wall biosynthesis does not override the dominant viral integration/latency theme. ","confidence":"High","size":23,"edges":238,"triangles":1495,"max_degree":22,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":7},{"id":"GO:0006260","count":6},{"id":"GO:0075732","count":5},{"id":"GO:0046718","count":5},{"id":"GO:0039651","count":5}]},{"hash":"1985777563181470974","title":"Ribosome Biogenesis and Translation Initiation","description":"The top terms are dominated by ribosome biogenesis and translation initiation processes (ribosomal subunit biogenesis, formation of preinitiation complex, translation reinitiation, regulation of translational initiation, and viral IRES-dependent initiation/termination-reinitiation), pointing to a coherent theme of ribosome assembly and control of protein synthesis. While some terms like cell division appear, they are less central than the core translation machinery signals.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0000747","count":3}]},{"hash":"1502289561688026111","title":"Organogenesis and embryonic development","description":"The terms include heart, retina, placenta, thyroid, and bone development, plus embryonic eye morphogenesis, indicating a cohesive theme of organogenesis and differentiation across multiple tissues. Also present are broad regulators like transcription by RNA polymerase II and insulin signaling, consistent with growth and regulatory control during development.","confidence":"High","size":23,"edges":62,"triangles":49,"max_degree":10,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008285","count":7},{"id":"GO:0048048","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0002087","count":6},{"id":"GO:0006366","count":6}]},{"hash":"2288726405778188286","title":"Ubiquitin-Dependent Protein Degradation and Host Interaction","description":"Top GO terms are dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, K48-linked ubiquitination, autoubiquitination), pointing to proteasome-mediated protein turnover. Several terms also reflect interactions with host cells, including viral entry and proviral latency, suggesting the proteins may participate in host-pathogen modulation in concert with ubiquitin signaling. The overall pattern supports a theme of ubiquitin-regulated protein degradation coupled with host manipulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0035914","count":3},{"id":"GO:0070936","count":3},{"id":"GO:0016558","count":3},{"id":"GO:0051865","count":3}]},{"hash":"2118984738530036130","title":"Spermatogenesis and piRNA processing","description":"The GO terms converge on germ cell development, especially spermatid differentiation and male meiosis, with supporting roles for piRNA processing and epigenetic regulation (DNA methylation, transcriptional repression). This pattern strongly suggests a germline/meiosis-focused cluster, despite some broader developmental terms. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0034587","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0043046","count":2},{"id":"GO:0007289","count":2}]},{"hash":"1384017036727403441","title":"Cellular Stress Response and Translational Regulation","description":"The GO terms point mainly to cellular stress responses (oxidative stress from hydrogen peroxide, UV-induced stress, acidic pH, hypoxia-related signaling) and to control of protein synthesis (GCN2-mediated signaling, regulation of translation in stress), with additional signaling and checkpoint elements (DNA damage checkpoint, regulation of protein complex assembly). A few terms about morphogenesis or androgen signaling are less central, but the dominant pattern is stress response combined with translational control.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070301","count":2},{"id":"GO:0060325","count":1},{"id":"GO:0000077","count":1},{"id":"GO:0060733","count":1},{"id":"GO:1904803","count":1}]},{"hash":"1234374451026617897","title":"Neuronal development and synaptic signaling","description":"Most top GO terms cluster around nervous system development, axon guidance, synapse regulation, and ionotropic glutamate receptor signaling, with associated calcium homeostasis in the smooth ER. This pattern indicates a neuronal development and synaptic function theme; a few terms about placental branching and amyloid fibril formation may reflect broader pleiotropy, but the dominant signal is neural differentiation and synaptic signaling.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010951","count":6},{"id":"GO:0035235","count":5},{"id":"GO:0051563","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0060672","count":5}]},{"hash":"1216847290869710107","title":"Unknown","description":"The top GO terms are a mix of lipid metabolism (fatty-acyl-CoA and cholesterol transport), transcription regulation, and unrelated themes such as Sertoli cell development and circadian/light signaling, offering no single cohesive function for the cluster. Because these functions do not converge on a clear shared activity, a precise, representative label cannot be confidently assigned.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0036111","count":1},{"id":"GO:1901373","count":1},{"id":"GO:0032385","count":1},{"id":"GO:0036112","count":1}]},{"hash":"1014796356347158877","title":"Neuronal Development","description":"The top GO terms center on neural development (striatum development, pyramidal neuron development), indicating the cluster is enriched for proteins involved in neuronal differentiation and maturation. Secondary terms point to basic metabolism and cell division, which may reflect housekeeping roles or co-regulated processes, but neural development appears to be the dominant theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0021756","count":3},{"id":"GO:0046677","count":3},{"id":"GO:0072756","count":2}]},{"hash":"1810552835046659335","title":"Unknown","description":"The top GO terms are highly diverse, spanning ubiquitin-dependent proteolysis, circadian rhythm regulation, muscle differentiation and sarcomere organization, organ morphogenesis, plant-specific metabolism, viral latency, and mitotic spindle localization. There is no clear, cohesive biological theme linking these terms, suggesting the cluster is functionally heterogeneous rather than representing a single pathway or process.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":15},{"id":"GO:0042752","count":12},{"id":"GO:0019762","count":9},{"id":"GO:0035914","count":9},{"id":"GO:0031397","count":9}]},{"hash":"1895807600225474001","title":"Rho GTPase signaling and actin dynamics","description":"The cluster is dominated by GO terms for regulation of Rho protein signal transduction, small GTPase-mediated signaling, and actin cytoskeleton organization, including positive regulation of GTPase activity and processes like podosome assembly, stress fiber dynamics, and leading-process extension in migrating neurons. This points to a core theme of cytoskeletal remodeling and cell motility driven by Rho-family GTPases, with ancillary signaling pathways (growth hormone/insulin receptor signaling) that may intersect with cytoskeletal regulation. Overall, the most representative function across this set is Rho GTPase\u2013mediated actin dynamics and motility.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0060396","count":2},{"id":"GO:0007264","count":2},{"id":"GO:0030036","count":2},{"id":"GO:0046626","count":2}]},{"hash":"886472057377682373","title":"Angiogenesis and vascular morphogenesis","description":"This cluster\u2019s top GO terms cluster strongly around blood vessel formation and vascular development (angiogenesis, retinal vessel morphogenesis, placental branching morphogenesis) and related cardiovascular regulation (arterial pressure). While there are some outliers related to endocytosis, immune activation, and neuronal plasticity, the dominant signal points to vascular morphogenesis as the shared theme. Name chosen to be specific and representative of the core function.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0060672","count":3},{"id":"GO:0060325","count":3},{"id":"GO:0010800","count":2},{"id":"GO:0003050","count":2}]},{"hash":"1029964503572036193","title":"Heart development and cardiac muscle contraction","description":"The strongest signals in this cluster are heart development and cardiac muscle contraction, with supporting terms like actin cytoskeleton organization, which together point to a cardiovascular muscle function. Some other terms (DNA-templated transcription, DNA integration, signaling) are more general or non-cardiac, which lowers but does not negate the cardiovascular interpretation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0022011","count":2}]},{"hash":"533920531513220455","title":"Bone remodeling and immune-coagulation signaling","description":"This cluster's terms link bone biology (Wnt signaling pathway, biomineral tissue development) with immune and coagulation processes (complement activation, Factor XII activation, fibrinolysis, defense against fungus). The combination suggests a theme around bone remodeling influenced by immune/coagulation signaling, even though there is no observed edge structure in the network, so the label reflects a best-effort high-level function rather than a tightly connected module.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016055","count":2},{"id":"GO:0071333","count":1},{"id":"GO:0003050","count":1},{"id":"GO:0031214","count":1},{"id":"GO:0006958","count":1}]},{"hash":"1645864551679360103","title":"Cardiac GPCR Signaling and Contraction Regulation","description":"These proteins cluster around GPCR-mediated signaling in the heart, including acetylcholine and tachykinin receptor pathways, GPCR desensitization/internalization, and regulation of cardiac muscle contraction and vascular smooth muscle relaxation. The shared themes point to GPCR-driven control of heart contraction and vascular tone, justifying this label.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0045988","count":3},{"id":"GO:0060048","count":3},{"id":"GO:0007217","count":3},{"id":"GO:0002031","count":3}]},{"hash":"373614302785391609","title":"Proteolysis and Peptide Processing","description":"Based on the dominance of GO terms for proteolysis, protein autoprocessing, angiotensin maturation, digestion, and antigen processing via MHC II, this cluster seems centered on proteolytic processing of proteins into peptides for hormone maturation, digestion, and immune presentation. Some terms like touch perception and embryonic development are broader or indirect but do not outweigh the strong proteolytic theme.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050975","count":2},{"id":"GO:0035556","count":2},{"id":"GO:0001701","count":2},{"id":"GO:0016540","count":2},{"id":"GO:0002803","count":2}]},{"hash":"1114886568027379645","title":"Developmental signaling and lineage differentiation","description":"These GO terms cluster around developmental processes across multiple tissues (chondrocyte, retina, dopaminergic neurons, blood vessels, osteoblasts) and involve signaling and transcription regulation (ERK cascade, Wnt signaling, GTPase activity, RNA Pol II transcription). This suggests a theme of developmental signaling coordinating lineage specification and tissue morphogenesis, rather than a single specific pathway.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002063","count":2},{"id":"GO:0060059","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0090263","count":2},{"id":"GO:0043547","count":2}]},{"hash":"2082007308661800933","title":"Developmental Regulation and Tissue Differentiation","description":"Proteins in this cluster show links to multicellular development, heart and bone-related differentiation, and processes involved in tissue morphogenesis such as cell spreading and tight junction regulation. The presence of DNA-templated transcription points to regulatory roles, while some sensory-perception terms may reflect broader annotation. Overall, the cluster appears focused on developmental differentiation and tissue formation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0050907","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0033138","count":2}]},{"hash":"597253349709480991","title":"Dopamine/Adrenergic GPCR Signaling and Heart Development","description":"The cluster is enriched for GPCR-mediated signaling that activates adenylate cyclase and cAMP (dopamine/adrenergic pathways), plus related processes like heart development, cell proliferation, and GTPase regulation. Cocaine-response and phototransduction terms reflect broader GPCR roles in behavior and sensory signaling, supporting a cohesive theme around catecholamine GPCR signaling influencing development and physiology.","confidence":"Medium","size":22,"edges":190,"triangles":901,"max_degree":21,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":18},{"id":"GO:0007507","count":17},{"id":"GO:0007191","count":16},{"id":"GO:0008284","count":16},{"id":"GO:0043950","count":16}]},{"hash":"536359070887945834","title":"Dopaminergic GPCR-cAMP signaling and inflammation","description":"The top GO terms cluster around dopamine receptor signaling and GPCR-related cAMP regulation (GO:0007191, GO:2000479, GO:0051586), with related immune/inflammatory activities such as dendritic cell chemotaxis and chronic inflammatory response (GO:0002407, GO:0002882). While there are also terms like blood coagulation and xenobiotic response, the core signal points to dopaminergic GPCR signaling pathways that interface with immune modulation. This makes the label a concise summary of the dominant theme in the cluster.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0042493","count":2},{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1}]},{"hash":"1642321311865560479","title":"Apoptosis and Complement-Mediated Immune Clearance","description":"The top terms cluster around apoptotic processes (apoptotic process, recognition of apoptotic cell) and innate immune signaling (complement activation, classical pathway), indicating a cohesive theme of apoptotic cell clearance by immune mechanisms; other terms reflect broader stress or remodeling responses but do not redefine the core function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0043654","count":2},{"id":"GO:0015917","count":2},{"id":"GO:0003050","count":2}]},{"hash":"860724075583504241","title":"Apoptosis-Linked Xenobiotic Metabolism Proteins","description":"The top GO terms emphasize apoptotic processes and recognition of apoptotic cells, pointing to a core role in apoptosis signaling; alongside this, xenobiotic metabolism and ER-targeting terms suggest involvement in ER-associated processing and detoxification pathways, indicating a broader stress-response context rather than a single, cohesive function.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0043654","count":2},{"id":"GO:0015917","count":2},{"id":"GO:0045047","count":1},{"id":"GO:0006465","count":1}]},{"hash":"2201345295798625694","title":"ECM Remodeling in Development","description":"The cluster\u2019s top terms center on collagen/fibril organization and endochondral ossification, indicating a shared role in extracellular matrix (ECM) remodeling and tissue morphogenesis. Developmental processes like eye morphogenesis and collagen-related signaling support a cohesive theme of ECM-mediated development, though ancillary terms such as complement activation and sodium channel clustering suggest broader functional diversity. Overall, the theme points to ECM-driven development and signaling with moderate confidence.","confidence":"Medium","size":22,"edges":78,"triangles":129,"max_degree":18,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001958","count":6},{"id":"GO:0033034","count":6},{"id":"GO:2000534","count":6},{"id":"GO:0038063","count":6},{"id":"GO:0001867","count":6}]},{"hash":"308625464417001903","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":21,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0060291","count":2},{"id":"GO:0060292","count":2},{"id":"GO:1904751","count":2},{"id":"GO:0000390","count":2},{"id":"GO:0008380","count":2}]},{"hash":"642174075595745966","title":"Ubiquitin-dependent protein turnover and cell cycle control","description":"Most terms cluster around ubiquitination: K48- and K63-linked ubiquitination, ubiquitin-dependent protein catabolic process, and protein ubiquitination (including autoubiquitination). This indicates the proteins are involved in tagging substrates for degradation and ubiquitin signaling. Additional terms point to developmental roles (in utero embryonic development, atrial septum development) and regulatory control of apoptosis and transcription and cell cycle, suggesting these ubiquitin-related proteins influence growth and cell-cycle progression during development. Overall, the cluster is best described as ubiquitin-mediated protein turnover with links to cell cycle regulation.","confidence":"High","size":22,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070936","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0051865","count":3},{"id":"GO:0001701","count":2},{"id":"GO:0043066","count":2}]},{"hash":"201661086706953227","title":"Developmental gene regulation and organogenesis","description":"The top GO terms cluster around development of multiple organs (brain, retina, skeletal system, male gonad) and DNA-templated transcription, suggesting a group of proteins focused on controlling gene expression during development. Additional regulatory processes (GTPase and ubiquitin ligase activity, translation initiation, SREBP signaling) fit within broad developmental regulation and cellular homeostasis. Overall, the theme is development-driven gene regulation with supporting cellular processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0008584","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0000724","count":3},{"id":"GO:0048705","count":3}]},{"hash":"966059917407905346","title":"Odontogenesis and dental mineralization","description":"Top GO terms center on tooth eruption, odontoblast differentiation, dentinogenesis, enamel mineralization, and related craniofacial bone mineralization. This points to a shared function in odontogenesis and mineralized dental tissues, rather than unrelated pathways.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044691","count":1},{"id":"GO:0045669","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0030501","count":1},{"id":"GO:0036179","count":1}]},{"hash":"986538325495685761","title":"Neuronal Synaptic Transmission and Sensory Processing","description":"Many terms point to neuronal signaling and information processing (GABA receptor clustering, cholinergic transmission, excitatory/inhibitory potentials, sensory processing, circadian regulation). A couple terms appear less related (acrosome reaction, cartilage morphogenesis), but the dominant theme is neural signaling.","confidence":"High","size":22,"edges":137,"triangles":365,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":19},{"id":"GO:0060079","count":19},{"id":"GO:0045188","count":19},{"id":"GO:0097112","count":19},{"id":"GO:2001226","count":19}]},{"hash":"2176944900921872985","title":"RNA processing and translation initiation","description":"This cluster centers on RNA maturation, splicing, and export (spliceosome, preinitiation complex formation, mRNA export) as well as translation initiation events (IRES-dependent initiation, translation reinitiation). The shared theme is RNA metabolism spanning nuclear processing to cytoplasmic translation control, making this label a concise representation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0006378","count":8},{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8}]},{"hash":"1565026164059679748","title":"Unknown","description":"The top terms span diverse processes\u2014from centrosome cycle and apoptosis signaling to neural transmission, axon regeneration, cell migration, and various endocrine signaling pathways\u2014showing no single cohesive function linking the proteins. The absence of edges and a unifying pathway suggests no clear cluster function, hence Unknown.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007098","count":2},{"id":"GO:0020021","count":2},{"id":"GO:0035249","count":2},{"id":"GO:0048680","count":2},{"id":"GO:0016477","count":2}]},{"hash":"825169695867123052","title":"Oskar mRNA Localization and Developmental Regulation","description":"The top GO terms point to oskar mRNA localization in the pole plasm and regulation of its translation, indicating a germline localization role, while other terms touch on broader developmental processes such as neural differentiation, synaptic assembly, stem cell maintenance, and meiosis. The mix suggests a general theme of developmental gene regulation with some germline mRNA localization aspects, but the lack of cohesive, tightly connected functions (no edges) lowers confidence in a single precise role. ","confidence":"Low","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":1},{"id":"GO:0040039","count":1},{"id":"GO:0000381","count":1},{"id":"GO:0007317","count":1},{"id":"GO:0019827","count":1}]},{"hash":"394540690079837502","title":"Metabolic Biosynthesis and Transcription","description":"This cluster shows strong signals for multiple biosynthetic metabolic processes (pyruvate, fatty acids, carbohydrates, lipopolysaccharide, cobalamin, phospholipid-related) alongside DNA-templated transcription, indicating a mix of metabolic enzymes and transcription-related proteins rather than a single, cohesive pathway.","confidence":"Medium","size":22,"edges":96,"triangles":214,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0042866","count":4},{"id":"GO:0055089","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0046839","count":3}]},{"hash":"1803441572142288786","title":"Unknown","description":"The terms span diverse processes (muscle growth, cuticle/molting, proteolysis, development, reproduction, organ morphogenesis, autophagy, aging) across different contexts with no clear common function, and there are no edges linking proteins to suggest a single cohesive theme. Therefore a specific, representative label cannot be assigned.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0007313","count":1},{"id":"GO:2000360","count":1}]},{"hash":"772308941566589622","title":"Viral infection and host manipulation","description":"This cluster centers on pathogen\u2013host interaction processes: infection structure formation, viral penetration into the host nucleus, proviral latency, and host apoptosis modulation. Additional terms about symbiont entry and host cell interactions reinforce a common theme of microbial entry and manipulation of host cells, with some insect-development context terms present. Overall, a coherent label is a short description of virus\u2013host interaction and infection-related steps.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006486","count":5},{"id":"GO:0075015","count":4},{"id":"GO:0042248","count":3},{"id":"GO:0001744","count":3},{"id":"GO:0007299","count":3}]},{"hash":"830993871740780204","title":"Embryonic patterning and morphogenesis","description":"The GO terms cluster around left-right pattern formation, EMT in endocardial cushion formation, placenta development, cartilage morphogenesis, and pancreatic cell development, pointing to a coherent theme of embryonic patterning and tissue morphogenesis. A couple of metabolic terms appear, but they do not define the cluster\u2019s primary function.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009228","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0046653","count":4},{"id":"GO:0043046","count":4},{"id":"GO:0000122","count":3}]},{"hash":"1629098514439690464","title":"Ubiquitin-Proteasome System in Innate Immunity","description":"Most terms point to ubiquitin-dependent protein degradation (proteasomal and ERAD pathways) with specific ubiquitin linkages and autoubiquitination, coupled to innate immune signaling such as NF-kappaB and TNF pathways and defense responses to virus.","confidence":"High","size":22,"edges":22,"triangles":3,"max_degree":7,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":12},{"id":"GO:0031146","count":7},{"id":"GO:0030433","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0070534","count":6}]},{"hash":"776104109159435279","title":"DNA Replication and Repair with Proviral Latency","description":"The top terms cluster around core DNA maintenance functions\u2014DNA replication, recombination, base-excision repair, and translesion synthesis\u2014plus RNA-templated DNA biosynthesis, indicating a cohesive DNA replication/repair theme. A subset of terms about viral entry and proviral latency suggests these proteins may participate in host DNA processing that viruses exploit for integration and latency, providing a plausible link between replication/repair and proviral states. Overall, the dominant signal is DNA replication/repair with an auxiliary viral integration context.","confidence":"High","size":22,"edges":127,"triangles":295,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":8},{"id":"GO:0006310","count":7},{"id":"GO:0070987","count":4},{"id":"GO:0070301","count":4},{"id":"GO:0006284","count":4}]},{"hash":"637933523248643042","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0060972","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0060806","count":1},{"id":"GO:0003323","count":1}]},{"hash":"1294437817679847825","title":"Developmental morphogenesis and transcriptional regulation","description":"This cluster\u2019s top GO terms point to developmental morphogenesis of facial structures and the inner ear (semicircular canal, face morphogenesis) along with processes related to transcriptional control (negative regulation of transcription by RNA Pol II) and epigenetic modification (H3-K9 trimethylation). The combination suggests a cohesive theme of development coordinated by transcriptional and chromatin-level regulation, despite some broader terms present. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048752","count":2},{"id":"GO:0060325","count":2},{"id":"GO:0036124","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0016049","count":2}]},{"hash":"1840653200819790071","title":"Multi-tissue Embryonic Morphogenesis","description":"The top GO terms point to embryonic development and organ morphogenesis across multiple tissues (eye, heart, hindlimb, placenta, gonads, habenula, prostate), suggesting a shared multi-organ developmental function rather than a tissue-specific role.","confidence":"High","size":22,"edges":153,"triangles":450,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":10},{"id":"GO:0007507","count":9},{"id":"GO:2000288","count":9},{"id":"GO:0060527","count":9},{"id":"GO:0021986","count":9}]},{"hash":"1419645732381892650","title":"Multilineage differentiation signals","description":"These proteins are associated with differentiation across multiple lineages (immune, neural, muscle, fat) and include involvement in key signaling pathways (Wnt, B cell receptor), as well as processes regulating differentiation and development. The diverse GO terms point to a broad, cross-lineage regulatory theme rather than a single coherent pathway, so a label reflecting multilineage differentiation cues fits well.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0050853","count":2}]},{"hash":"1810197309695568996","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":215,"triangles":1248,"max_degree":21,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0046827","count":21},{"id":"GO:0010571","count":20},{"id":"GO:0007098","count":20},{"id":"GO:0060258","count":19},{"id":"GO:0010825","count":19}]},{"hash":"2297478993516236021","title":"Actin Cytoskeleton Remodeling & PI3K Signaling","description":"Top terms indicate cortical actin cytoskeleton organization, lamellipodium assembly, and PI3K/AKT signaling, suggesting proteins that coordinate actin dynamics via PI3K pathways. Some terms (cardiac muscle contraction, spinal cord development, visual learning) are broader or peripheral, but the core theme is cytoskeletal remodeling regulated by PI3K signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030866","count":2},{"id":"GO:0060048","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0043491","count":2},{"id":"GO:0010592","count":2}]},{"hash":"2125693739835902669","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0048146","count":2},{"id":"GO:0019076","count":1}]},{"hash":"1279218663164213983","title":"ER stress and calcium homeostasis regulators","description":"The cluster\u2019s GO terms predominantly point to negative regulation of unfolded protein response and ER stress signaling, along with ER calcium ion homeostasis and related calcium transport regulation, suggesting these proteins act as regulators of ER stress responses and calcium homeostasis. Some terms are obsolete or tangential (e.g., response to L-glutamate), but the core theme remains ER stress/calcium regulation.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904721","count":2},{"id":"GO:1902065","count":2},{"id":"GO:1990441","count":2},{"id":"GO:0090005","count":2},{"id":"GO:0060702","count":2}]},{"hash":"2138337710438857492","title":"Embryonic development and tissue morphogenesis","description":"The proteins show enrichment for embryonic and CNS development, planar polarity, craniofacial skeleton morphogenesis, and sarcomere organization, pointing to roles in tissue formation and organization. Signaling pathways such as Rho signaling and ERK cascade are consistent with developmental regulation. While immune-related terms appear, the core pattern centers on morphogenesis and tissue organization, making this label representative despite possible annotation noise.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0001736","count":2},{"id":"GO:0048701","count":2},{"id":"GO:0007417","count":2},{"id":"GO:0045214","count":2}]},{"hash":"1191388502753492621","title":"Mitochondrial Metabolite Transport","description":"The top GO terms are dominated by transport and exchange of metabolites across the mitochondrial membranes (pyrimidine nucleotides, thiamine pyrophosphate, coenzyme A, heme, ATP) and processes like the malate-aspartate shuttle, plus regulation of mitochondrial membrane potential. These together point to a cluster of mitochondrial transport/metabolism functions rather than a cytosolic process. IGF signaling and pregnancy terms appear incidental. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0043490","count":2},{"id":"GO:1990544","count":2},{"id":"GO:0030974","count":2}]},{"hash":"72466697948880871","title":"Negative Regulation of Signaling and Receptor Turnover","description":"The cluster is enriched for GO terms that converge on suppressing signaling pathways (T cell receptor signaling, ERK/MAPK cascade, IL-6 signaling, STAT phosphorylation, PDGFR signaling) and on ubiquitin-dependent protein turnover via multivesicular body sorting, i.e., receptor downregulation and protein catabolism. A brain development term (cerebellar cortex formation) is present but appears secondary to the predominant theme of downregulating signaling and promoting receptor turnover. ","confidence":"Medium","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0050860","count":20},{"id":"GO:0070373","count":20},{"id":"GO:0000200","count":20},{"id":"GO:0008285","count":17},{"id":"GO:0021697","count":17}]},{"hash":"1638869956210842469","title":"Cardiac development and calcium signaling","description":"The GO terms show a strong link to heart formation and function: outflow tract morphogenesis, regulation of SA node cell action potential, Purkinje signaling to ventricular cardiac muscle cells, and cardiac muscle contraction, with a key emphasis on calcium handling via release of sequestered Ca2+ from the sarcoplasmic reticulum. While there are also broader developmental terms like ossification and skin development, the core cluster centers on cardiac development and excitation-contraction coupling, supported by calcium signaling components.","confidence":"High","size":21,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0060048","count":4},{"id":"GO:0003151","count":3},{"id":"GO:0098907","count":3}]},{"hash":"1131735835553493184","title":"Multisubstrate Membrane Transporters","description":"Based on the GO terms, the proteins are annotated with transmembrane transport across a diverse set of substrates\u2014nitrate/nitrite, various ions (sodium, potassium), arabinose, vitamins, sialic acid, xenobiotics, and other small molecules. This pattern points to a cluster of broad-spectrum transporter proteins rather than a single-substrate family, justifying a label of multisubstrate membrane transporters.","confidence":"High","size":21,"edges":19,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":5},{"id":"GO:0042128","count":5},{"id":"GO:1900754","count":5},{"id":"GO:0035461","count":5},{"id":"GO:0015706","count":5}]},{"hash":"863515229097885769","title":"Regulatory signaling and metabolic processes","description":"The terms cluster around regulation of diverse processes, including metabolism (glycogen catabolic process, fatty acid and nitric oxide biosynthesis) and signaling/development (glutamatergic synaptic transmission, oogenesis, yeast response), suggesting a broad regulatory role rather than a single pathway.","confidence":"Medium","size":21,"edges":192,"triangles":1040,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0045818","count":2},{"id":"GO:0001878","count":2},{"id":"GO:0048477","count":2},{"id":"GO:0051968","count":2},{"id":"GO:0008285","count":1}]},{"hash":"1883983666700797394","title":"Collagen-Driven ECM Remodeling and Morphogenesis","description":"This cluster\u2019s terms center on collagen fibril organization, collagen-activated signaling, and developmental processes like post-embryonic morphogenesis and endochondral ossification, indicating a core theme of extracellular matrix remodeling and collagen-mediated development. Immune-related terms (complement activation) appear but do not override the ECM/development signal, so the label appropriately captures the main function of the cluster.","confidence":"Medium","size":21,"edges":60,"triangles":21,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0040032","count":7},{"id":"GO:0042338","count":7},{"id":"GO:0001958","count":6},{"id":"GO:0033034","count":6},{"id":"GO:2000534","count":6}]},{"hash":"2069207359005258925","title":"Unknown","description":"No GO terms are listed under Top Terms, so I can't infer a common function for these 21 proteins. Without shared GO annotations or enriched processes, there is no clear theme to label. The connectivity metrics do not point to a specific pathway. ","confidence":"","size":21,"edges":161,"triangles":664,"max_degree":18,"top_function":null,"top_go_terms":[]},{"hash":"1751094348635758361","title":"Neuronal calcium signaling and synaptic transmission","description":"The top GO terms point to calcium handling (calcium ion transport; store-operated calcium entry) and synaptic activity (excitatory postsynaptic potential; dopamine uptake in synaptic transmission), suggesting a module centered on calcium-regulated neuronal signaling and neurotransmission, with some unrelated terms likely reflecting noise or multifunctionality.","confidence":"Medium","size":21,"edges":28,"triangles":11,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0060263","count":2},{"id":"GO:0000060","count":2},{"id":"GO:2001256","count":1},{"id":"GO:0006816","count":1},{"id":"GO:0051586","count":1}]},{"hash":"602162497416524233","title":"Developmental morphogenesis and post-transcriptional regulation","description":"Most top GO terms cluster around organismal development and morphogenesis (post-embryonic body morphogenesis, cuticle development in molting, pronephric glomerulus morphogenesis) with supporting themes of cytoskeletal signaling (Rho) and gene expression control (negative translation regulation, poly(A) tail shortening). While some terms are broader (blood circulation, viral process, meiosis), the dominant pattern indicates a developmental morphogenesis focus with post-transcriptional regulation.","confidence":"Medium","size":21,"edges":26,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0040032","count":2},{"id":"GO:0042338","count":2},{"id":"GO:0017148","count":2},{"id":"GO:0000289","count":2},{"id":"GO:0035775","count":1}]},{"hash":"836353361461157737","title":"Neuronal Synapse Development and Vesicle Trafficking","description":"The cluster is enriched for brain development, dendritic spine development, and synapse assembly, plus vesicle fusion and Golgi-to-plasma-membrane transport, all core processes in neuronal synapse formation and trafficking. The Rho signaling term supports actin remodeling at synapses, strengthening the link to neuronal connectivity; a few outlier terms appear but do not override the overall neuronal synapse/trafficking theme.","confidence":"High","size":21,"edges":95,"triangles":114,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0060999","count":2},{"id":"GO:0006906","count":2},{"id":"GO:0043001","count":2}]},{"hash":"1851372482423554615","title":"Fatty acid and lipid biosynthesis","description":"The dominant GO terms are all lipid-related biosynthetic processes (very long-chain fatty acids, sphingolipids, mycolic acids, methyl-branched fatty acids, and fatty acid elongation), suggesting the cluster centers on lipid metabolism. A few non-lipid terms appear, but the lipid biosynthesis signal is clear and representative of the cluster.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042761","count":2},{"id":"GO:0030148","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0042574","count":1},{"id":"GO:0071768","count":1}]},{"hash":"330300694001546280","title":"Zinc Ion Homeostasis and Detoxification","description":"GO terms show strong representation of zinc-related processes: intracellular zinc ion homeostasis, zinc ion transmembrane transport, and detoxification of zinc and cadmium ions; cobalt and iron terms are present but less central. Proteasome assembly and endopeptidase regulation appear only marginally. Overall, the dominant theme is zinc ion management and detoxification, so the label fits well.","confidence":"High","size":21,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043248","count":1},{"id":"GO:0010950","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0032119","count":1},{"id":"GO:0071577","count":1}]},{"hash":"1147760635390165709","title":"Unknown","description":"The GO terms are highly diverse, with only a couple pointing to neural development/g behavior (social behavior, cerebellar granule cell differentiation) while others cover redox/oxidative stress, mitochondrial import, autophagy, iron homeostasis, and even plant photomorphogenesis and germ-line feminization. There is no single coherent function linking the proteins, so a precise label isn\u2019t identifiable.","confidence":"","size":21,"edges":27,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0045454","count":1},{"id":"GO:0045041","count":1},{"id":"GO:0016242","count":1}]},{"hash":"317781355209609732","title":"Developmental signaling and stress response","description":"The cluster combines transcription/splicing and gene regulation with developmental processes (forebrain and multicellular development) and signaling (JNK cascade), plus stress/immune-related terms (response to cocaine, defense against Gram-positive bacteria) and proteasomal degradation. This suggests a cohesive theme of developmentally coordinated signaling and transcriptional/stress regulation, rather than a single enzyme function.","confidence":"Medium","size":21,"edges":142,"triangles":527,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045292","count":6},{"id":"GO:0006351","count":6},{"id":"GO:0070317","count":5},{"id":"GO:0007275","count":5},{"id":"GO:0001403","count":5}]},{"hash":"1601070977762816138","title":"Unknown","description":"The Top Terms are diverse and do not point to a single cohesive function or pathway (ranging from protein catabolism and collagen biosynthesis to neural development, neurotransmitter handling, lipid biosynthesis, and musculoskeletal movement). With no connections among members (edges/triangles = 0), there isn\u2019t a consistent theme to name the cluster, so a specific label cannot be assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044257","count":1},{"id":"GO:1900148","count":1},{"id":"GO:0032964","count":1},{"id":"GO:1905045","count":1},{"id":"GO:0001306","count":1}]},{"hash":"63668356332804506","title":"Diverse Developmental Processes","description":"The top GO terms span a broad set of developmental and differentiation events across different tissues and organisms (e.g., ovarian follicle development, root hair and leg segmentation, insect visual primordium formation, egg chamber cell adhesion, seed coat mucilage development, and hypochord development). Since there isn\u2019t a single cohesive pathway but rather a variety of development-related processes, the cluster is best described by a general label reflecting diverse developmental roles.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006310","count":2},{"id":"GO:0001541","count":2},{"id":"GO:0080147","count":2},{"id":"GO:0002315","count":2},{"id":"GO:0048354","count":2}]},{"hash":"235893397521070917","title":"Unknown","description":"Unknown","confidence":"","size":21,"edges":210,"triangles":1330,"max_degree":20,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0045292","count":2},{"id":"GO:0006446","count":2}]},{"hash":"2224204824969547156","title":"ECM Remodeling and Tissue Morphogenesis","description":"The top terms cluster around basement membrane disassembly, bone resorption, decidualization, and epithelial tube branching in organ morphogenesis, together with related proteolysis and hormone-responsive processes, pointing to extracellular matrix remodeling guiding tissue development and remodeling. While immune and hormone signals appear, the dominant theme is matrix remodeling linked to morphogenesis.","confidence":"Medium","size":21,"edges":67,"triangles":192,"max_degree":12,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050790","count":12},{"id":"GO:0060441","count":12},{"id":"GO:0001913","count":12},{"id":"GO:0034769","count":12},{"id":"GO:0046697","count":12}]},{"hash":"530116219976146645","title":"Craniofacial skeletal development","description":"The top GO terms point to skeletal development and cartilage growth, especially embryonic cranial skeleton morphogenesis and growth plate chondrocyte growth, indicating a cohesive role in craniofacial skeletogenesis. Additional terms like DNA-templated transcription and neurotrophin signaling suggest regulatory and neuronal support aspects, but the strongest signal centers on skeletal morphogenesis. Overall, the cluster appears to represent genes involved in craniofacial skeletal formation and cartilage development.","confidence":"High","size":21,"edges":46,"triangles":26,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0001501","count":17},{"id":"GO:0003430","count":16},{"id":"GO:0020021","count":16},{"id":"GO:0048701","count":16}]},{"hash":"819557283465763543","title":"Unknown","description":"The top GO terms cover a wide and diverse set of processes (digestion, GTPase regulation, protein autoprocessing, actin nucleation regulation, cell proliferation, mRNA transport, hypoxia response, autophosphorylation, development, and mitotic cell cycle) with no clear shared function. There are no edges or clustering signals (max degree 0, no interactions) to tie these proteins into a single coherent biological theme, so a specific, representative label cannot be confidently assigned.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007586","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0016540","count":4},{"id":"GO:0034316","count":3},{"id":"GO:0008284","count":3}]},{"hash":"1778313508942045211","title":"Retroviral Entry and Proviral Latency","description":"The top GO terms point to a retroviral life cycle: entry into the host nucleus, reverse transcription and DNA synthesis, DNA integration, recombination, and establishment of integrated proviral latency, with additional signals of host defense modulation (siRNA processing regulation) and ubiquitin-mediated protein turnover. This cohesive set suggests coordinated viral genome integration and latency mechanisms rather than a generic DNA replication cluster.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":9},{"id":"GO:0075732","count":8},{"id":"GO:0046718","count":8},{"id":"GO:0039651","count":8},{"id":"GO:0075713","count":8}]},{"hash":"2020201912523303719","title":"Ubiquitin-Dependent Cell Cycle Regulation","description":"Most of the top GO terms cluster around cell division, mitosis, chromatid cohesion, and protein ubiquitination, pointing to a theme of ubiquitin-mediated regulation of the cell cycle. The presence of a few other developmental terms likely reflects pleiotropic roles or annotation overlap, but the core signal is cell cycle control via ubiquitination.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0051441","count":3},{"id":"GO:0008284","count":3}]},{"hash":"833510324903346571","title":"Neural and Skeletal Muscle Development","description":"The cluster shows a clear emphasis on developmental processes in neural and muscle tissues, with dominant GO terms such as nervous system development, neuron development, and skeletal muscle tissue development. Additional regulatory terms (DNA-templated transcription, estrogen response) fit into developmental regulation, though a few terms like B cell receptor signaling are less related, suggesting some wider regulatory roles. Overall, the strongest pattern supports a developmental theme focused on neural and muscular systems.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":3},{"id":"GO:0016242","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0043627","count":2}]},{"hash":"944357510973225054","title":"Redox metabolism and biosynthesis","description":"The dominant terms point to redox processes (oxidation-reduction, redox homeostasis, oxidant detoxification) and a variety of biosynthetic pathways (lipoteichoic acid, triglyceride, antibiotic, anthocyanin). This suggests a cluster of proteins involved in managing cellular redox state while supporting diverse biosynthetic activities, including bacterial and plant-associated processes. Some terms appear noisy or cross-species, but redox balance plus biosynthesis is the clearest unifying theme.","confidence":"Medium","size":21,"edges":95,"triangles":219,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0055114","count":7},{"id":"GO:0098869","count":7},{"id":"GO:0006641","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0009718","count":5}]},{"hash":"2198285138333938753","title":"Developmental transcriptional regulation and stress signaling","description":"The top GO terms cluster around DNA-templated transcription and tissue development (heart and nervous system), suggesting transcriptional regulation during development. Additional terms point to nuclear transport regulation and cellular stress responses (redox homeostasis and ER-stress\u2013induced apoptosis), indicating the proteins also participate in stress signaling pathways that intersect with development.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":10},{"id":"GO:0046826","count":9},{"id":"GO:0019858","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0045454","count":6}]},{"hash":"825429825532466293","title":"Cholesterol transport and lipid metabolism","description":"The top GO terms point to lipid trafficking and cholesterol handling: intracellular cholesterol transport, cholesterol transport involved in cholesterol storage, bile acid secretion, and ER-to-Golgi ceramide transport. There are also hormonally responsive and circadian terms (growth hormone, luteinizing hormone, glucocorticoid metabolism, circadian sleep/wake cycle), suggesting a broader endocrine regulation of lipid processes. The absence of edges indicates a loosely connected set of proteins identified by ReCIPE, but the common theme across the terms supports a cholesterol/lipid transport and metabolism function. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007165","count":2},{"id":"GO:0010879","count":1},{"id":"GO:0042747","count":1},{"id":"GO:0071378","count":1},{"id":"GO:0035621","count":1}]},{"hash":"2075822052516575233","title":"Genome maintenance and RNA processing","description":"This cluster contains GO terms for telomere maintenance and DNA repair, plus mitotic cohesion and several RNA-processing activities (polyadenylation, RISC assembly, rRNA/tRNA processing, transcription termination). The shared theme points to nuclear genome integrity and RNA metabolism, rather than a single cohesive complex. Given the mix of genome-stability and RNA-processing roles, the confidence is Medium.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000723","count":2},{"id":"GO:0006281","count":2},{"id":"GO:0034087","count":1},{"id":"GO:0007064","count":1},{"id":"GO:0006378","count":1}]},{"hash":"590650263649353674","title":"Fertilization and Early Embryonic Development","description":"This cluster is enriched for GO terms tied to fertilization and early embryo development, including regulation of sperm binding to the zona pellucida, prevention of polyspermy, and blastocyst formation, suggesting a reproductive/embryogenesis theme. Some viral-related terms appear, but the dominant signal points to fertilization and early development processes.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031953","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0060468","count":2},{"id":"GO:2000360","count":2},{"id":"GO:0001825","count":2}]},{"hash":"1333913032228572190","title":"Unknown","description":"The top GO terms are highly diverse, spanning T cell homeostasis and cytokine regulation (immune), hypoxia and carbon monoxide responses, cerebellar development, sensory perception (pain and touch), receptor signaling regulation, and potassium ion transport. This wide spread of biological processes provides no single cohesive theme tying the proteins together, suggesting no clear shared function for this cluster beyond a heterogeneous set of roles.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0002724","count":1},{"id":"GO:0034465","count":1},{"id":"GO:0021679","count":1}]},{"hash":"1979500236276429065","title":"Embryonic craniofacial and neural morphogenesis","description":"This cluster is dominated by GO terms tied to early embryonic development and tissue morphogenesis, especially craniofacial/skull morphogenesis, palate/roof of mouth development, cartilage formation, and neural (midbrain/forebrain) development, with additional heart-related outflow tract morphogenesis and primitive streak formation. A single term on transcriptional regulation is peripheral. Overall, the proteins appear to function together in embryonic morphogenesis, with emphasis on craniofacial and neural patterning.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0060021","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0003148","count":3}]},{"hash":"2006433461391590755","title":"RNA splicing and post-transcriptional regulation","description":"The cluster is dominated by RNA processing and post-transcriptional control terms: spliceosome-mediated alternative splicing, small-subunit processome assembly, mRNA stabilization, and miRNA-mediated translational inhibition, plus IRES-dependent translation initiation. While a couple terms touch on vesicle transport or differentiation, the core signal is RNA processing and regulation after transcription.","confidence":"High","size":20,"edges":177,"triangles":973,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0000380","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0045654","count":2},{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1}]},{"hash":"1573085565588986768","title":"Membrane Solute Transporters","description":"The top GO terms point to transmembrane transport of a variety of solutes (calcium, amino acids, nitrates, arabinose, vitamins, xenobiotics), suggesting these proteins are membrane transporters handling multiple substrates. The lone development-related term (face morphogenesis) is likely incidental noise in this cluster. Overall, the shared function appears to be generic solute transport across the plasma membrane.","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990034","count":1},{"id":"GO:0032973","count":1},{"id":"GO:0015672","count":1},{"id":"GO:0060325","count":1},{"id":"GO:0006855","count":1}]},{"hash":"368026274420040956","title":"Diverse Substrate Transporters","description":"Most of the top terms are transmembrane transport activities for various substrates (xenobiotics, nitrate, arabinose, vitamins, ions, sialic acid, etc.). The lack of a single dominant substrate or pathway suggests a cluster of diverse transporter proteins rather than a single functional family.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015706","count":1}]},{"hash":"693825183718112905","title":"Membrane Junctions and Neural-Immune Signaling","description":"The cluster includes GO terms pointing to membrane organization and junctional/barrier functions (tight junction assembly, endothelial barrier establishment, transcytosis, eisosome assembly) alongside neural signaling (myelination, synaptic plasticity, sensory perception of sound) and immune signaling (B cell receptor signaling, B-1a differentiation) as well as apoptotic signaling pathways. This suggests a group of proteins involved in membrane-associated signaling at cell boundaries across neural and immune contexts, rather than a single, narrow function. Therefore, a label emphasizing membrane junctions with neural and immune signaling best captures the shared theme.","confidence":"Medium","size":20,"edges":147,"triangles":599,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0070830","count":1},{"id":"GO:0042552","count":1},{"id":"GO:0045056","count":1},{"id":"GO:0061028","count":1},{"id":"GO:0070941","count":1}]},{"hash":"1846992720438492746","title":"ER protein processing and trafficking","description":"The GO terms dominated by ER-related processes: protein localization to the endoplasmic reticulum, ER unfolded protein response, COPII-coated vesicle budding, and general ER-associated trafficking, point to a core theme of ER quality control and secretory pathway handling. Some terms like cytoplasmic translation, olfactory learning, and meiosis appear as outliers, but the ER-centric terms are the most representative for this cluster. Confidence: Medium","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0007060","count":2},{"id":"GO:0008355","count":2},{"id":"GO:0044828","count":1},{"id":"GO:0060304","count":1}]},{"hash":"137571606469638733","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":168,"triangles":801,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":20},{"id":"GO:0010825","count":20},{"id":"GO:0070935","count":20},{"id":"GO:0003430","count":20},{"id":"GO:0020021","count":20}]},{"hash":"1444576214804125100","title":"Epigenetic Regulation in Organ Development","description":"Top GO terms center on histone modifications (acetylation and methylation of H3K4, H3K23, H3K27) and their regulation, with supporting signals for animal organ development and thymus epithelium morphogenesis, plus roles in centrosome cycle and apoptotic signaling. This suggests proteins tied to epigenetic control during development and cell-cycle decision-making. Some terms are obsolete, and the connections are not tightly cohesive, but the overall theme points to developmental epigenetics.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048513","count":1},{"id":"GO:0043972","count":1},{"id":"GO:0097536","count":1},{"id":"GO:0051569","count":1},{"id":"GO:0061087","count":1}]},{"hash":"446276151698960053","title":"Vesicle trafficking and membrane organization","description":"The set is dominated by terms tied to vesicle formation, coating, and transport (COPI coating, ER-to-Golgi transport, Golgi vesicles, lysosomal membrane organization, synaptic vesicle budding) and their regulation by small GTPases, plus related membrane- and secretory-related processes (acrosome and podosome contexts). While some terms are species-specific, the unifying theme is membrane dynamics and vesicle trafficking across cellular compartments.","confidence":"Medium","size":20,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0010227","count":1},{"id":"GO:0071803","count":1},{"id":"GO:1902307","count":1},{"id":"GO:0097212","count":1},{"id":"GO:0048205","count":1}]},{"hash":"308484238024543653","title":"Retroviral Entry and Proviral Latency","description":"The cluster centers on GO terms tied to viral entry into host cells, integration into the host genome, proviral latency, and reverse transcription-like RNA-templated DNA synthesis, with supporting DNA replication/recombination and RNAi suppression signals. This combination strongly aligns with retroviral life cycle processes, making the label specific and representative.","confidence":"High","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3},{"id":"GO:0039651","count":3}]},{"hash":"296119412179544698","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0019076","count":1},{"id":"GO:0010587","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0039651","count":1}]},{"hash":"1800206104891966958","title":"Amino acid biosynthesis and translation","description":"The dominant terms are translation and L-threonine biosynthetic process, suggesting a core link to protein synthesis and amino acid metabolism. Additional GO terms indicate related stress responses (antibiotic/cycloheximide) and other cellular processes, but the shared theme across the cluster centers on biosynthesis of amino acids and the machinery for protein production. ","confidence":"Medium","size":20,"edges":34,"triangles":70,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0009088","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0019284","count":2}]},{"hash":"603130732103902743","title":"Chloroplast/mitochondrial translation and ribosome assembly","description":"The cluster is dominated by translation- and ribosome-related GO terms (translation, ribosome assembly, and mitochondrial translation) and includes photosynthesis, which points to chloroplast function. This suggests the proteins are linked to organelle protein synthesis and assembly, rather than broader immune signaling which appears only sparsely. Confidence in this thematic label is High.","confidence":"High","size":20,"edges":190,"triangles":1140,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0046677","count":3},{"id":"GO:0070131","count":2},{"id":"GO:0042255","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2191020303809641014","title":"Translation Initiation and Ribosome Assembly","description":"The cluster is dominated by GO terms related to translation initiation and ribosome assembly (formation of translation preinitiation complex, cytoplasmic translation initiation complex, translation, translational initiation, and cytosolic ribosome assembly) with a notable signal for regulation of initiation. While some terms touch on brain development or germ cell proliferation, the strongest and most coherent theme across the set is components and regulation of the translation initiation machinery. ","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":3},{"id":"GO:0001732","count":2},{"id":"GO:0002176","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006413","count":2}]},{"hash":"1980243067084757733","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":52,"triangles":55,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0006452","count":1}]},{"hash":"841588689764343555","title":"Unknown","description":"Unknown","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0071630","count":1},{"id":"GO:0006452","count":1}]},{"hash":"621086725012747369","title":"RNA processing and translation initiation control","description":"This cluster centers on RNA metabolism and translation machinery: regulatory ncRNA-mediated gene silencing, mRNA stability regulation, splicing regulation, preinitiation complex formation, small-subunit processome assembly, and various modes of translation initiation (including IRES-dependent and reinitiation), plus mRNA stabilization. The common thread is post-transcriptional RNA processing and initiation of translation, suggesting coordinated control of gene expression at the RNA level.","confidence":"High","size":20,"edges":147,"triangles":550,"max_degree":18,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":10},{"id":"GO:0010610","count":10},{"id":"GO:0048026","count":10},{"id":"GO:1901407","count":9},{"id":"GO:0006378","count":9}]},{"hash":"1196958522042042475","title":"Arabinogalactan protein glycosylation and mucilage biosynthesis","description":"The cluster\u2019s top GO terms cluster around arabinogalactan protein metabolism, O-linked glycosylation, and mucilage/seed coat polysaccharide biosynthesis, pointing to a shared theme of plant cell-surface glycoprotein production and glycan modification. While some terms touch on broader developmental processes (root hair formation, epithelial adhesion), these can be influenced by glycosylation and AGP function, supporting a cohesive AGP/glycosylation\u2013related biosynthesis theme.","confidence":"Medium","size":20,"edges":35,"triangles":8,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0080147","count":6},{"id":"GO:0042248","count":5},{"id":"GO:0048354","count":5},{"id":"GO:0010405","count":5},{"id":"GO:0010493","count":5}]},{"hash":"1530367135084503188","title":"Vacuolar amino acid transport","description":"The GO terms are dominated by transmembrane import of multiple amino acids into the vacuole (lysine, tyrosine, histidine, alanine, serine, proline) with a note of lysine export from the vacuole, pointing to a cohesive function in vacuolar amino acid transport. The presence of multiple specific amino acid import terms strongly supports a single theme rather than disparate processes.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901482","count":3},{"id":"GO:0090452","count":3},{"id":"GO:0090514","count":3},{"id":"GO:0061402","count":3},{"id":"GO:0090513","count":3}]},{"hash":"6016526423709756","title":"Unknown","description":"The top GO terms span very different processes (DNA damage response and replication unwinding, ubiquitin-dependent proteolysis, chlorophyll biosynthesis, stamen development, proteasome assembly, integrin signaling, protein complex formation, transcription regulation, and rRNA maturation) across bacteria, plants, and animals. This lack of a unifying function suggests annotation noise or a mix of unrelated pathways, so there is no clear cluster theme to label with confidence.","confidence":"","size":20,"edges":48,"triangles":21,"max_degree":10,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0009432","count":6},{"id":"GO:0006268","count":6},{"id":"GO:0006511","count":6},{"id":"GO:0015995","count":6},{"id":"GO:0048455","count":6}]},{"hash":"1202092707951599279","title":"Signaling and trafficking in motile cells","description":"The cluster highlights regulation of kinase activity, TORC2 signaling, vesicle trafficking (COPII budding), and motility-related processes (podosome assembly, hemocyte migration, locomotory behavior), suggesting a shared theme of coordinated signaling and intracellular transport that governs cell movement and cytoskeletal dynamics. Some terms like androgen receptor signaling and cell cycle are less cohesive but do not overturn the prevailing motif.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0045859","count":3},{"id":"GO:0035641","count":3},{"id":"GO:1904515","count":3},{"id":"GO:0090114","count":3}]},{"hash":"1728116099969371137","title":"Embryonic Development and Organogenesis","description":"The proteins are enriched for GO terms spanning embryogenesis and morphogenesis across multiple organs (heart, eye, limb, nervous system, pituitary, gonads), plus gastrulation-related processes (primitive streak formation) and transcriptional regulation during development, indicating a cohesive embryonic development module.","confidence":"High","size":20,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0000122","count":9},{"id":"GO:0090009","count":7},{"id":"GO:0021983","count":7},{"id":"GO:0048935","count":7},{"id":"GO:0048048","count":6}]},{"hash":"2242402168745465473","title":"Ribosome Biogenesis and Cell Cycle","description":"The dominant terms center on ribosome biogenesis and rRNA maturation, with strong links to cell division and mitotic sister chromatid cohesion, suggesting a core theme around ribosome assembly and its connection to cell cycle regulation; a few unrelated terms (development, signaling, ubiquitination) appear as secondary annotations but do not outweigh the primary signal.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000463","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0000209","count":4},{"id":"GO:0000747","count":4}]},{"hash":"1454474488317147581","title":"Cell division and development proteins","description":"The top GO terms point to core cell-cycle activities (cell division, mitotic sister chromatid cohesion), ubiquitination, and RNA/vesicle transport, alongside developmental processes (brain/spinal cord and male gonad development). This suggests a broad set of proteins involved in fundamental cellular machinery with roles in development, rather than a single cohesive pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0008584","count":2},{"id":"GO:0010255","count":2}]},{"hash":"408834854713985519","title":"ER protein processing and COPII trafficking","description":"This cluster shows enrichment for endoplasmic reticulum localization, COPII-coated vesicle budding, and ER unfolded protein response, plus calcium homeostasis, all pointing to ER-based protein processing and secretory pathway function. Some virus-host interaction terms are present but do not override the ER-focused theme.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044828","count":2},{"id":"GO:0060304","count":2},{"id":"GO:0090114","count":2},{"id":"GO:0070972","count":2},{"id":"GO:0030968","count":2}]},{"hash":"1217405379394392756","title":"Lymphocyte activation and proliferation","description":"The GO terms show a clear immune focus: T cell cytokine regulation, regulation of activated T cell apoptosis, dendritic cell differentiation, and cell\u2013cell adhesion\u2014all core to immune cell communication and activation. Coupled with DNA replication and sister chromatid cohesion, this points to proliferation that accompanies immune responses. While there are non-immune terms (e.g., xenobiotic response), they can reflect stress- or stimulus-induced immune activity. Overall, the cluster centers on immune cell signaling and expansion.","confidence":"High","size":20,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007157","count":2},{"id":"GO:0007064","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0071333","count":1}]},{"hash":"271195947573869170","title":"Unknown","description":"The proteins in this cluster map to a wide range of distinct processes (ribosome biogenesis and rRNA maturation; various transport and signaling/differentiation terms) and have no edges to suggest a common pathway. This lack of a cohesive theme makes it infeasible to assign a specific, representative function label.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035626","count":1},{"id":"GO:0031032","count":1},{"id":"GO:1904706","count":1},{"id":"GO:0030855","count":1},{"id":"GO:0050765","count":1}]},{"hash":"1322306327462869954","title":"Developmental signaling and tissue differentiation","description":"This cluster features several development-related terms across different tissues (neural crest, Schwann cells, mammary gland), plus associated signaling activities (JAK-STAT, nitric oxide biosynthesis) and cell-surface localization, suggesting a broad theme of developmental programs and cell communication guiding tissue formation rather than a single, cohesive pathway.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001755","count":3},{"id":"GO:2000010","count":2},{"id":"GO:0007479","count":2},{"id":"GO:2000252","count":2},{"id":"GO:2000366","count":2}]},{"hash":"1330159911420481760","title":"Immune signaling and hematopoiesis","description":"The cluster\u2019s top GO terms point to immune cell signaling and development: integrin-mediated signaling, small GTPase/Rho signaling, NK T cell differentiation, cytokine-related responses (IL-4, IL-7), and hemopoiesis. Together these suggest a cohesive theme of leukocyte activation/differentiation and blood cell production, with additional adhesion and cytoskeletal remodeling processes. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071226","count":10},{"id":"GO:0007229","count":8},{"id":"GO:0030097","count":8},{"id":"GO:0001867","count":7},{"id":"GO:0001502","count":7}]},{"hash":"1013690981686709111","title":"Spinal Cord Neurodevelopment and Migration","description":"The cluster is driven by neural development terms: spinal cord interneuron specification/differentiation, lateral motor column neuron migration, and lamellipodium assembly, plus related signaling and transcription (growth hormone signaling, RNAP II transcription, SMAD-related turnover). While a few terms (platelet aggregation, seed morphogenesis) are less aligned, the core theme centers on neural development and cell migration.","confidence":"Medium","size":20,"edges":39,"triangles":51,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0070527","count":5},{"id":"GO:0008585","count":5},{"id":"GO:0060396","count":4},{"id":"GO:0097477","count":4},{"id":"GO:0021521","count":4}]},{"hash":"59386502882398510","title":"GTPase-Regulated Membrane Trafficking in Nervous System","description":"Based on the top GO terms, the cluster centers on regulation and signaling of small GTPases (Rho, Rab, Rap) that control endosome-to-Golgi and plasma membrane\u2013endosome trafficking, along with membrane tubulation. The presence of spinal cord development and myelination terms suggests a neuronal context, indicating a link between GTPase signaling, membrane trafficking, and nervous system development.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":3},{"id":"GO:0021510","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0034499","count":2},{"id":"GO:0032486","count":2}]},{"hash":"1337128506096980016","title":"Meiosis/oogenesis and neural development","description":"The cluster is dominated by processes related to oocyte maturation and spindle assembly in female meiosis, with microtubule dynamics and ubiquitin-proteasome\u2013mediated protein degradation, while also including neural development terms such as neural tube closure initiation and third ventricle development, indicating a shared developmental program linking meiosis/oogenesis with brain development.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006516","count":5},{"id":"GO:0021993","count":5},{"id":"GO:0008285","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0046785","count":5}]},{"hash":"2093811725089066915","title":"Retroviral Integration and Latency","description":"The top GO terms cluster around steps of a retroviral life cycle: DNA integration, recombination, replication, RNA-templated DNA synthesis (reverse transcription), entry into the host nucleus, and establishment of integrated proviral latency, plus host interactions like modulation of RNA processing and signaling. This coherent set points to retroviral integration and latency as the central theme.","confidence":"High","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0006310","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075732","count":3},{"id":"GO:0046718","count":3}]},{"hash":"1834098312703560174","title":"Negative Regulation of Immune Cell Migration and Vessel Remodeling","description":"The cluster\u2019s top GO terms cluster around suppressing immune cell movement and vascular remodeling (negative regulation of blood vessel remodeling, cellular extravasation, and neutrophil degranulation), suggesting a shared role in down-regulating immune/vascular remodeling processes. Supporting terms related to signaling and cell-cycle regulation (phosphatidylinositol phosphate biosynthesis, serine phosphorylation, mitotic spindle assembly) indicate broader regulatory connections but do not outweigh the dominant theme of down-regulation of movement and remodeling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060313","count":2},{"id":"GO:0038028","count":2},{"id":"GO:0002692","count":2},{"id":"GO:0043314","count":2},{"id":"GO:0009738","count":2}]},{"hash":"712725051528097791","title":"ECM Organization and Integrin Signaling","description":"This cluster is dominated by GO terms related to extracellular matrix organization, notably collagen fibril organization, and integrin-mediated signaling, suggesting a core theme of ECM\u2013cell adhesion and communication. Additional terms such as blood coagulation, fibroblast migration, and smooth muscle development point to tissue remodeling in connective/vascular contexts. A few terms (e.g., obsolete NF-kappaB regulation, general protein targeting) are peripheral, but the core function appears to be ECM organization and integrin-driven signaling.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":2},{"id":"GO:0007229","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0006616","count":1}]},{"hash":"2025902934969624858","title":"Drosophila sensory organ development and transcription regulation","description":"This cluster emphasizes antennal and compound eye photoreceptor development and dual roles in transcriptional regulation, suggesting a developmental program in Drosophila sensory organs. Additional terms like nonsense-mediated decay and glycosylation are general processes that accompany such regulation but are less specific to this cluster.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0043086","count":2},{"id":"GO:0006646","count":2},{"id":"GO:0006355","count":1}]},{"hash":"417970564964566543","title":"Lipid Biosynthesis and Remodeling","description":"This cluster is dominated by lipid-related biosynthetic processes, including CDP-diacylglycerol biosynthesis, phosphatidylcholine biosynthesis and remodeling, and ether lipid biosynthesis (with a plant-associated cutin term), pointing to a core theme of membrane lipid production and turnover. The presence of a mitochondrial ATP synthesis term aligns with the energy needs of lipid biosynthesis, while a few other terms related to development or immune signaling appear as peripheral associations. Overall, the proteins are best grouped by lipid metabolism and membrane remodeling functions.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010143","count":2},{"id":"GO:0042775","count":1},{"id":"GO:0008611","count":1},{"id":"GO:0070970","count":1},{"id":"GO:2001246","count":1}]},{"hash":"1678681801569028963","title":"Translation machinery and mRNA regulation","description":"The GO terms are dominated by translation and ribosome-related processes (translation, translational initiation/elongation/termination, mitochondrial translation, ribosome disassembly, and mRNA decay), indicating the cluster centers on protein synthesis and its regulation. A couple of terms (midbrain morphogenesis and regulation of Rho signaling) appear with lower counts and are likely incidental. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:1904693","count":2},{"id":"GO:1902802","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0070125","count":1}]},{"hash":"1072981798678017241","title":"Unknown","description":"The GO terms are highly diverse, spanning lipid biosynthesis, RNA processing, protein modification, DNA repair, translation initiation, and cellular stress and fate (senescence, apoptosis). There is no single dominant shared function linking the proteins, so a cohesive, intuitive label cannot be justified beyond Unknown. ","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016024","count":2},{"id":"GO:0090398","count":1},{"id":"GO:0016126","count":1},{"id":"GO:0018013","count":1},{"id":"GO:0034462","count":1}]},{"hash":"1193000632656643068","title":"Angiogenesis and ECM Remodeling with Immune Regulation","description":"This cluster centers on terms tied to vascular growth (positive regulation of angiogenesis), extracellular matrix organization (collagen fibril), and growth responses (epithelial proliferation, TGF-beta stimulus). It also includes immune-related processes (complement activation, negative regulation of antigen presentation via MHC II) and TNF production, plus mRNA transport, suggesting a broad regulatory module that links vascular remodeling with immune signaling and growth factor responses rather than a single narrow function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0050679","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0042535","count":1}]},{"hash":"600930996543453496","title":"Developmental morphogenesis and differentiation","description":"The cluster\u2019s top GO terms cluster around broad developmental and tissue-formation processes, including multicellular organism development, skin development, cartilage condensation, and spinal cord neuron differentiation, with additional hints of fertilization and nervous system functions (e.g., zona pellucida penetration, sensory perception of pain). This suggests a general theme of developmental biology and tissue morphogenesis across multiple lineages rather than a single, specific pathway, making a label like Developmental morphogenesis and differentiation appropriate. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":6},{"id":"GO:0007275","count":4},{"id":"GO:0043588","count":4},{"id":"GO:0006695","count":4},{"id":"GO:0008542","count":4}]},{"hash":"483768568415188085","title":"Lipid metabolism and epidermal/cuticle development","description":"The cluster shows strong representation of lipid-related processes (cholesterol metabolic process, sphingolipid metabolic process, regulation of cholesterol biosynthetic process) alongside epidermal/cuticle development signals (skin development, molting cycle, collagen-based cuticle). While there are some neural-related terms (spinal cord motor neuron differentiation, thermoception, membrane hyperpolarization), the dominant theme appears to tie lipid metabolism to epidermal/cuticle formation and associated developmental processes, suggesting a cohesive, lipid-centric developmental module.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0010875","count":3},{"id":"GO:0008203","count":3},{"id":"GO:0018996","count":3},{"id":"GO:0001502","count":2}]},{"hash":"316280101462257916","title":"Cytoskeleton organization and endocytosis","description":"The cluster is enriched for terms on microtubule/tubulin complex assembly, endocytosis, cell polarity, and vacuolar membrane localization, indicating a shared role in cytoskeleton-driven trafficking and cell shape control. While a subtelomeric heterochromatin term appears, the strongest signals relate to cytoskeletal dynamics and vesicle movement, including GTPase activity regulation. Thus \"Cytoskeleton organization and endocytosis\" captures the main theme.","confidence":"Medium","size":19,"edges":72,"triangles":102,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0032966","count":4},{"id":"GO:0051291","count":4},{"id":"GO:0007021","count":3},{"id":"GO:1903778","count":3},{"id":"GO:0071963","count":3}]},{"hash":"1886973644351571457","title":"RNA processing and ribosome biogenesis","description":"This cluster is enriched for RNA metabolism and protein synthesis processes: ribosome biogenesis, snoRNP assembly, translation, spliceosome assembly and mRNA splicing/processing. The combination of ribosome/translation terms with spliceosomal and snoRNP-related terms suggests a cohesive module of RNA maturation and ribosome assembly linked to translation initiation, including IRES-dependent mechanisms.","confidence":"High","size":19,"edges":167,"triangles":903,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":5},{"id":"GO:0000492","count":4},{"id":"GO:0006412","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0046330","count":3}]},{"hash":"979705338725531706","title":"PNS axon growth and neurofilament assembly","description":"The cluster shows strong signals for neuronal structure and growth: neurofilament bundle assembly, regulation of axon diameter, peripheral nervous system axon regeneration, and microtubule cytoskeleton polarity. Some worm-specific terms (molting, pharyngeal pumping) and a few unrelated processes may reflect species-specific or incidental annotations, but the core theme centers on neuronal cytoskeleton organization and axon regrowth.","confidence":"Medium","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0043050","count":2},{"id":"GO:0031081","count":1},{"id":"GO:0032980","count":1},{"id":"GO:0001867","count":1}]},{"hash":"437035835270639097","title":"Proteostasis and microtubule dynamics","description":"This cluster is dominated by GO terms related to protein folding, chaperone-mediated assembly, and ubiquitin-proteasome\u2013mediated quality control, alongside tubulin complex assembly and cortical microtubule organization. These shared themes point to maintenance of protein homeostasis together with cytoskeletal organization, suggesting a coherent functional core despite some unrelated physiological terms in the list.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042766","count":2},{"id":"GO:0071629","count":1},{"id":"GO:0007021","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0043622","count":1}]},{"hash":"1089670190973751358","title":"ERAD and ER Localization","description":"Most top GO terms cluster around retrograde transport from the ER to cytosol, ER membrane localization, and ubiquitin-dependent degradation (ERAD). This points to a coherent theme of endoplasmic reticulum protein quality control and localization, despite a few outlier terms. Thus, the cluster is best described as ERAD/ER localization.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030970","count":1},{"id":"GO:0010936","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0097051","count":1},{"id":"GO:0036010","count":1}]},{"hash":"1827890445815254719","title":"Macrophage immune signaling and transcriptional regulation","description":"A cluster dominated by transcription-related GO terms (DNA-templated transcription; RNA Pol II elongation) together with immune activation signals (macrophage activation, TLR4 signaling). This pattern suggests proteins coordinating transcriptional responses during macrophage immune signaling.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0034145","count":2},{"id":"GO:0006368","count":2},{"id":"GO:0002281","count":2},{"id":"GO:0000750","count":1}]},{"hash":"1923304323538074827","title":"Taste and Osmotic Homeostasis Sensing","description":"The terms cluster around chemosensory taste (salt and sour), salt aversion, pH response, and water homeostasis, with related references to systemic regulation (blood pressure baroreceptor feedback) and mechanosensory signaling. This suggests a theme of sensory detection of ionic/osmotic status linked to organismal fluid balance and physiological regulation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003026","count":1},{"id":"GO:0050891","count":1},{"id":"GO:0050914","count":1},{"id":"GO:0035002","count":1},{"id":"GO:0050915","count":1}]},{"hash":"1798646476340306674","title":"Unknown","description":"The GO terms span muscle growth regulation, cuticle molting, proteolysis, embryonic morphogenesis, reproductive events (polyspermy prevention, sperm binding), and nematode-specific processes, with no single shared function or pathway tying them together, so a coherent cluster label cannot be assigned.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0007313","count":1},{"id":"GO:2000360","count":1}]},{"hash":"2023175642054316703","title":"Glutathione detoxification and redox regulation","description":"The cluster is enriched for redox/detoxification GO terms (cellular oxidant detoxification, glutathione metabolic process, detoxification of nitrogen compounds) and also shows links to apoptosis and signaling regulation (negative regulation of ERK cascade, extrinsic apoptotic signaling). This points to a coherent theme of oxidative stress defense and glutathione-mediated detoxification, with some steroid signaling interactions (response to estradiol) and proliferative regulation that may be indirect. Overall, a redox-detox theme best represents the group.","confidence":"High","size":19,"edges":171,"triangles":969,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":19},{"id":"GO:2000255","count":19},{"id":"GO:0032355","count":18},{"id":"GO:0060316","count":18},{"id":"GO:0071672","count":18}]},{"hash":"1597757606213367444","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032933","count":3},{"id":"GO:0000447","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0036265","count":2}]},{"hash":"1430479184892921811","title":"Collagen-ECM Signaling in Development","description":"The dominant signals point to collagen fibril organization and collagen-activated tyrosine kinase receptor signaling, linking ECM remodeling to developmental processes such as endochondral ossification and camera-type eye morphogenesis. Complement activation and regulation of immune and kidney-related processes suggest ancillary immune-modulatory roles and tissue remodeling within developing tissues. Overall, the theme is ECM-driven signaling coordinating tissue development, with some immune involvement.","confidence":"Medium","size":19,"edges":7,"triangles":0,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001958","count":4},{"id":"GO:0033034","count":4},{"id":"GO:2000534","count":4},{"id":"GO:0038063","count":4},{"id":"GO:0001867","count":4}]},{"hash":"1805042813717156382","title":"Developmental Signaling and Cell Migration","description":"The terms point to signaling pathways that guide development and movement of cells across tissues\u2014especially neural development (ROBO signaling, axon guidance, nervous system development) but also immune cell signaling (T cell receptor signaling, mast cell chemotaxis), along with broader developmental processes (ossification, spermatid development, cell polarity). This suggests a theme of developmental signaling coordinating cell navigation and maturation across systems, rather than a single, narrow function.","confidence":"Medium","size":19,"edges":142,"triangles":574,"max_degree":18,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0043931","count":5},{"id":"GO:0002551","count":5}]},{"hash":"2033552413006190547","title":"Neural-immune development regulators","description":"The top GO terms point to neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) and immune signaling (T cell and B cell receptor pathways), with additional mentions of heart development and insulin signaling. This suggests proteins that regulate developmental signaling with involvement in both neural and immune contexts, rather than a single narrow pathway. Confidence: Medium","confidence":"","size":19,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0008285","count":4},{"id":"GO:0021697","count":4},{"id":"GO:0060020","count":4},{"id":"GO:0050852","count":4}]},{"hash":"550334822121288448","title":"Neuronal development and synapse organization","description":"The top GO terms center on neural development and synaptic architecture (synapse organization, sympathetic nervous system development, sensory perception of sound) with additional signals related to neuron survival (negative/positive regulation of neuron apoptotic process, apoptotic process) and cell cycle. Although the interaction graph has no edges, the functional emphasis points to neural development and synaptic function rather than other biological processes, with a few peripheral terms like osmosensory signaling. This supports a cohesive theme around neuronal development and synaptic organization.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050808","count":3},{"id":"GO:0048485","count":2},{"id":"GO:0007605","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0043525","count":2}]},{"hash":"556728675972358390","title":"Proteolysis and Antigen Processing","description":"The cluster's top GO terms center on proteolytic activity (proteolysis, protein catabolic process, autoprocessing, digestion) and immune-related processing (antigen processing and presentation via MHC II, antibacterial peptide production). This suggests proteins linked by proteolytic processing that supports immune functions, with some broader roles like peptide maturation and development in peripheral terms. Therefore, the label highlights the core theme: proteolysis feeding antigen processing.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0006508","count":5},{"id":"GO:0016540","count":4},{"id":"GO:0002803","count":4},{"id":"GO:0019886","count":4},{"id":"GO:0009627","count":4}]},{"hash":"560670351020765738","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034414","count":1},{"id":"GO:0038202","count":1},{"id":"GO:1990928","count":1},{"id":"GO:0075522","count":1},{"id":"GO:0006396","count":1}]},{"hash":"195217705864861568","title":"Embryonic and Organ Morphogenesis","description":"This cluster centers on developmental and morphogenetic processes across multiple organs (heart, eye, hindlimb, mammary gland, growth plate), suggesting a shared function in organ formation and tissue remodeling. Though some terms touch cholesterol homeostasis or immune signaling, the strongest signal is embryonic organ morphogenesis, supporting a broad developmental label rather than a single pathway. ","confidence":"Medium","size":19,"edges":28,"triangles":4,"max_degree":9,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007507","count":5},{"id":"GO:0042632","count":5},{"id":"GO:0071222","count":5},{"id":"GO:0048048","count":4},{"id":"GO:0050680","count":4}]},{"hash":"266939238210753803","title":"mRNA maturation and translation control","description":"The top GO terms cluster around mRNA processing (splicing via spliceosome, small-subunit processome assembly, polyadenylation), mRNA stabilization, and translation regulation (translation initiation/reinitiation, and miRNA-mediated translational inhibition), suggesting a cohesive role in post-transcriptional gene regulation from RNA processing to control of translation.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0034462","count":4}]},{"hash":"129571602776429998","title":"Neuronal development and synaptic signaling","description":"The cluster is enriched for terms tied to nervous system development, ionotropic glutamate receptor signaling, regulation of synapse structure/activity, and calcium handling in the endoplasmic reticulum, pointing to neural development and synaptic function as the core theme. Some terms like molting or placental branching may reflect broader developmental processes or annotation noise, but the dominant signals converge on neuronal connectivity and signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":2},{"id":"GO:0007064","count":2},{"id":"GO:0035235","count":2},{"id":"GO:0051563","count":2},{"id":"GO:0010951","count":2}]},{"hash":"2301710420287725412","title":"Cilia-Driven Sensory Signaling","description":"This cluster centers on cilia-related processes (motile cilium assembly) and sensory perception (touch and vision) with associated signaling roles (ERK cascade, peptidyl-serine phosphorylation) and related trafficking/development steps, suggesting a cilia-to-sensory signaling theme. Some terms (apoptotic process, DNA integration) are less clearly connected, so confidence is limited.","confidence":"Low","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":4},{"id":"GO:0070374","count":2},{"id":"GO:0050975","count":2},{"id":"GO:0033138","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1371537314302410","title":"Neural GPCR Signaling and Brain Development","description":"Top GO terms point to brain development and neural signaling, notably acetylcholine receptor\u2013GPCR signaling and small GTPase pathways. The presence of locomotory behavior, axon injury response, and vascular development terms suggests a neurovascular signaling role rather than a strictly neural or strictly vascular function. Thus, the cluster appears to group proteins involved in neural development and GPCR/small GTPase signaling, with secondary vascular context.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0008344","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0060313","count":2},{"id":"GO:0048678","count":2}]},{"hash":"2073171802584696850","title":"Neuronal signaling and barrier regulation","description":"The top GO terms show a clear emphasis on neural activity, including chemical synaptic transmission, morphine response, and behaviors like exploration and grooming, along with paranodal junction maintenance. A vascular/epithelial angle appears via endothelial intestinal barrier establishment, suggesting a theme of neural signaling intertwined with barrier/junction regulation. While a few terms touch immune or renal processes, the dominant signal points to neural communication and associated barrier/junction dynamics.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090557","count":4},{"id":"GO:0007268","count":4},{"id":"GO:0008285","count":4},{"id":"GO:2000670","count":4},{"id":"GO:2000821","count":4}]},{"hash":"1626302480529226937","title":"Embryonic Patterning and Morphogenesis","description":"This cluster centers on developmental patterning and morphogenesis: left/right patterning, EMT in heart cushion formation, placenta/endocrine development, cartilage morphogenesis, trophoblast differentiation, and guidance cues for neurons and endothelial cells. The GO terms collectively point to embryonic development and tissue formation rather than a single pathway.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0060806","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060536","count":3}]},{"hash":"1275709854721996797","title":"Endosomal Trafficking and Vesicle Fusion","description":"The proteins are dominated by GO terms tied to vesicle transport and fusion: intracellular protein transport, endosomal vesicle fusion, vesicle targeting, endocytic recycling, late endosome to lysosome transport, and vacuole fusion. SNARE complex regulation further supports a vesicular fusion theme, while TORC1 signaling regulation hints at growth\u2013trafficking coordination. A septum disassembly term is peripheral. Together these indicate a cohesive cluster of endosomal/lysosomal trafficking and fusion functions.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904263","count":2},{"id":"GO:0035542","count":1},{"id":"GO:0006886","count":1},{"id":"GO:0030994","count":1},{"id":"GO:0031532","count":1}]},{"hash":"1794783900185555272","title":"Nucleobase Transport Across Membranes","description":"The top GO terms are dominated by import/transport of nucleobases (guanine, adenine, hypoxanthine, uracil, urate, xanthine) across the plasma membrane, plus a general transmembrane transport category. An outlier term (thalamus development) appears irrelevant to the main theme, suggesting the cluster mainly groups nucleobase transporters. ","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021794","count":2},{"id":"GO:0070478","count":2},{"id":"GO:0098710","count":1},{"id":"GO:0098702","count":1},{"id":"GO:0070904","count":1}]},{"hash":"759428806659067593","title":"Diverse Biosynthetic Metabolism","description":"The top GO terms span a wide range of biosynthetic and metabolic activities\u2014retinal metabolism, fatty acid elongation, various hormone and steroid biosynthesis, sugar-derived nucleotide biosynthesis, lipopolysaccharide core biosynthesis, and related catabolic processes\u2014showing no single cohesive pathway or tissue-specific function. This suggests the cluster groups proteins by general metabolic roles rather than a unified biological process, so a broad label like Diverse Biosynthetic Metabolism fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":1},{"id":"GO:0019305","count":1},{"id":"GO:0071768","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0009710","count":1}]},{"hash":"42182630046251936","title":"Prostate epithelial development and trafficking","description":"The top GO terms cluster around prostate gland development and epithelial differentiation (e.g., epithelial cell differentiation involved in prostate gland development; prostate gland growth), suggesting a module tied to prostate development. The accompanying terms on endosome organization/transport, lamellipodium assembly, and cilium-related protein localization point to cellular trafficking and cytoskeletal dynamics that often accompany epithelial morphogenesis. Sphingolipid metabolism and GPCR signaling features further reflect membrane signaling contexts important for developmental processes. Together, these terms imply a developmental program in prostate epithelium with supporting trafficking and signaling activities.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060742","count":2},{"id":"GO:1903206","count":2},{"id":"GO:0006665","count":2},{"id":"GO:0060736","count":2},{"id":"GO:0007193","count":2}]},{"hash":"1520260245122003845","title":"Mitochondrial Complex IV Assembly","description":"The cluster's top GO term is mitochondrial respiratory chain complex IV assembly (1 member), suggesting a possible theme around assembly of Complex IV in mitochondria. However, there are no edges or shared annotations beyond that single term, so the connection across all 19 proteins is weak; the label is tentative and best viewed as representing a subset that may participate in Complex IV assembly.","confidence":"Low","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":1}]},{"hash":"1499365340543692275","title":"Lipid remodeling and biosynthesis","description":"The top GO terms are heavily centered on lipid metabolism, including phosphatidylcholine acyl-chain remodeling, ether lipid biosynthesis, and CDP-diacylglycerol biosynthesis, with mitochondrial ATP synthesis providing an energy context. While there are a few outlier terms related to development and immune signaling, the lipid-related processes best represent the cluster as a whole.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036151","count":4},{"id":"GO:2001246","count":4},{"id":"GO:0042775","count":3},{"id":"GO:0008611","count":3},{"id":"GO:0070970","count":3}]},{"hash":"2289675255438510861","title":"Glutamatergic signaling and neuronal development","description":"The top terms point to glutamate receptor regulation (AMPA and NMDA), chemical synaptic transmission, and neuronal development processes such as neuroblast division and neuron migration, implying roles in both synaptic signaling and neuronal maturation rather than a single pathway.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090502","count":2},{"id":"GO:0007565","count":1},{"id":"GO:2000311","count":1},{"id":"GO:0021813","count":1},{"id":"GO:2000310","count":1}]},{"hash":"1157345358611166679","title":"Embryogenesis, morphogenesis, and reproductive regulation","description":"This cluster centers on developmental and reproductive processes across species: maternal axis specification, embryonic morphogenesis (e.g., fin development), prevention of polyspermy, and regulation of sperm binding, paired with molting and tissue remodeling (proteolysis) and growth control terms. The common thread is developmental progression and reproduction rather than a single specific pathway or tissue, justifying a broad \u201cembryogenesis/morphogenesis/reproductive\u201d label.","confidence":"Medium","size":18,"edges":37,"triangles":15,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":3},{"id":"GO:0018996","count":3},{"id":"GO:0006508","count":3},{"id":"GO:0007313","count":3},{"id":"GO:2000360","count":3}]},{"hash":"449868636680624301","title":"Endocardial cushion formation and cardiac angiogenesis","description":"The cluster centers on cell adhesion (heterophilic and cell-matrix) and cell migration linked to endocardial cushion development and sprouting angiogenesis, pointing to a cardiac morphogenesis/vasculature module. Some terms (thyroid hormone generation, gamma-delta T cell differentiation) appear as outliers but don\u2019t override the core heart-development signal.","confidence":"Medium","size":18,"edges":23,"triangles":16,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0090050","count":8},{"id":"GO:0007160","count":7},{"id":"GO:1990134","count":7},{"id":"GO:0021865","count":6}]},{"hash":"1039261052482310299","title":"Dopaminergic and octopaminergic GPCR signaling","description":"The top GO terms point to monoaminergic GPCR signaling, especially dopamine-related pathways (dopamine uptake, dopamine receptor signaling, cAMP regulation) and octopamine/tyramine signaling, suggesting a core function in monoaminergic neural signaling. Other terms (immune/inflammatory and development) may reflect broader or secondary roles in this protein set. Overall, a cohesive label is centered on dopamine/octopamine GPCR signaling.","confidence":"Medium","size":18,"edges":10,"triangles":0,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051586","count":9},{"id":"GO:0002407","count":9},{"id":"GO:0002882","count":9},{"id":"GO:0031649","count":9},{"id":"GO:0002032","count":9}]},{"hash":"65543459662633604","title":"Epidermal differentiation and pigment cell biology","description":"The strongest GO signals are keratinocyte differentiation and melanocyte proliferation, pointing to skin-epithelial development and pigment cell biology. Cell adhesion and epithelial morphogenesis support tissue architecture, while other terms (nervous system development, placental branching, amyloid formation, detoxification, calcium homeostasis) appear as broader cellular processes or gene overlaps. Overall, the cluster seems dominated by epidermal differentiation and pigment-related functions.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030216","count":2},{"id":"GO:0097325","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0035235","count":1}]},{"hash":"1467548875651137618","title":"Developmental ECM Remodeling and Morphogenesis","description":"The top GO terms point to extracellular matrix remodeling (collagen fibril organization; collagen-activated tyrosine kinase receptor signaling), tissue morphogenesis (endochondral ossification; camera-type eye morphogenesis), and related signaling, with some complement pathway activity that can participate in developmental remodeling. This suggests a cohesive theme of ECM-driven development and organ formation rather than a single narrow function.","confidence":"Medium","size":18,"edges":17,"triangles":3,"max_degree":13,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001958","count":11},{"id":"GO:0033034","count":11},{"id":"GO:2000534","count":11},{"id":"GO:0038063","count":11},{"id":"GO:0001867","count":11}]},{"hash":"440105448437910029","title":"Negative Regulation of Immune Signaling and MAPK Pathways","description":"This cluster is dominated by GO terms for dampening B cell and T cell receptor signaling, ERK/MAPK cascades, and IL-6 signaling, along with related control of cell proliferation and ubiquitin-dependent protein turnover via multivesicular body sorting. While cerebellar cortex formation appears, the strongest pattern is immune signaling suppression and MAPK pathway regulation, pointing to proteins that act as negative regulators of cellular signaling and proliferation.","confidence":"High","size":18,"edges":44,"triangles":68,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0050859","count":7},{"id":"GO:0000200","count":7},{"id":"GO:0070373","count":7},{"id":"GO:0050860","count":7},{"id":"GO:0008285","count":6}]},{"hash":"174008668695200963","title":"Steroid receptor signaling and cell migration","description":"This cluster is enriched for steroid hormone receptor signaling terms (including androgen receptor signaling and its negative regulation), and for adhesion/motility processes (podosome assembly, substrate adhesion-dependent spreading, hemocyte migration), suggesting a cohesive theme of hormone-influenced cell movement and cytoskeletal remodeling. Supporting processes like xenobiotic response and reticulophagy/lysosomal regulation indicate broader stress-response and organelle turnover in concert with signal-driven migration.","confidence":"Medium","size":18,"edges":97,"triangles":262,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033144","count":13},{"id":"GO:1900026","count":13},{"id":"GO:0035690","count":12},{"id":"GO:0043524","count":12},{"id":"GO:0030521","count":11}]},{"hash":"931320417858904170","title":"Plasma Membrane Transport of Sugars and Ions","description":"A cluster whose top GO terms point to various transport processes across the plasma membrane, including sugar transport (trehalose, galactose, glucose), ion transport (sodium, phosphate, selenite), xenobiotic transport, and osmotic stress response, indicating a cohesive group of solute transporters and osmoregulatory proteins.","confidence":"Medium","size":18,"edges":51,"triangles":34,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":1},{"id":"GO:0006817","count":1},{"id":"GO:0015771","count":1},{"id":"GO:0052106","count":1},{"id":"GO:0006970","count":1}]},{"hash":"1197086289191337838","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":26,"triangles":9,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0071630","count":2},{"id":"GO:0006452","count":2}]},{"hash":"51445283358412736","title":"Neuronal development and synaptic signaling","description":"Based on the top GO terms, the proteins cluster around neuronal development (GO:0048666) and chemical synaptic transmission (GO:0007268), with supporting signals from actin filament bundle assembly (GO:0051017) relevant to synaptic structure and endocytosis regulation (GO:0045806) linked to synaptic vesicle recycling. Additional terms touch on insulin receptor signaling and cell volume, which can be relevant to neuronal physiology. Together, the dominant theme is neuronal differentiation and synaptic signaling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046626","count":2},{"id":"GO:0048666","count":2},{"id":"GO:0045737","count":2},{"id":"GO:0045806","count":2},{"id":"GO:0051017","count":2}]},{"hash":"2278968341796675429","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0016055","count":2},{"id":"GO:1904357","count":2}]},{"hash":"469751784591145856","title":"Developmental Signaling and Neuronal Guidance","description":"These proteins preferentially map to developmental signaling pathways and neural connectivity: Hedgehog Smoothened signaling, Slit-Robo axon guidance, and Rho-mediated signaling are central; nervous system development and dendrite self-avoidance indicate neuronal wiring, while kidney and heart development point to broader organogenesis. The presence of T cell receptor signaling and apoptotic processes suggests additional signaling roles but does not override the core developmental theme. Thus the cluster is best described as developmental signaling coordinating neural patterning and organogenesis.","confidence":"High","size":18,"edges":144,"triangles":683,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0007224","count":8},{"id":"GO:0007399","count":8},{"id":"GO:0001822","count":8},{"id":"GO:0035385","count":8},{"id":"GO:0035023","count":8}]},{"hash":"796843160775667355","title":"Mitochondria and Chloroplast Gene Expression","description":"The cluster\u2019s GO terms center on transcription and translation within organelles, including mitochondrial transcription and its regulation, plastid (chloroplast) rRNA transcription, chloroplast organization, plastid ribosome assembly, and mitochondrial electron transport, as well as general translation. This cohesive set points to the machinery that governs gene expression in mitochondria and chloroplasts, suggesting a shared organelle gene-expression function.","confidence":"High","size":18,"edges":153,"triangles":816,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0006390","count":1},{"id":"GO:1903108","count":1}]},{"hash":"875655574792324902","title":"Collagen-rich ECM and developmental signaling","description":"The top terms point to extracellular matrix biology (collagen biosynthesis and fibril organization) and cell adhesion, with developmental processes like limb bud formation and Hedgehog-related signaling and neural differentiation also represented. This suggests a cluster of proteins involved in ECM assembly/remodeling and development signaling, with some immune-related terms appearing less consistently. The lack of edges implies limited direct interactions in the current network, but a coherent ECM/development theme overall.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0045880","count":2},{"id":"GO:0032964","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0006958","count":2}]},{"hash":"1170617617219818661","title":"Ribosome Biogenesis and Translation","description":"The top GO terms are dominated by translation- and ribosome-related processes (translation, cytoplasmic translation, ribosomal large subunit assembly, ribosome biogenesis, translation termination), with additional terms suggesting bacterial stress and antibiotic-related responses that commonly intersect with ribosome function. This points to a coherent cluster of proteins involved in ribosome assembly and protein synthesis, plus related regulatory or stress-response links.","confidence":"High","size":18,"edges":150,"triangles":769,"max_degree":17,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":12},{"id":"GO:0000027","count":6},{"id":"GO:0006415","count":4},{"id":"GO:0002181","count":3},{"id":"GO:0046677","count":3}]},{"hash":"352698138436490612","title":"Ubiquitin-dependent degradation and RNA splicing","description":"This cluster is dominated by ubiquitin-related processes (ERAD, protein catabolic via ubiquitin, autoubiquitination) and RNA processing (mRNA splicing via spliceosome, snRNP assembly), suggesting a cohesive role in protein quality control coupled with RNA maturation. Other terms touch on growth and cell cycle but are less central.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0007049","count":1},{"id":"GO:0000398","count":1},{"id":"GO:2000825","count":1}]},{"hash":"576230050445288124","title":"Golgi\u2013plasma membrane transport and signaling","description":"The top GO terms cluster around intracellular trafficking between the Golgi and plasma membrane (Golgi to PM transport; endosome-to-Golgi retrograde transport) and associated signaling modules (Wnt signalosome, Smoothened pathway, Rac signaling) with calcium-dependent exocytosis, suggesting a functional group centered on membrane trafficking linked to signal transduction. Some terms (kidney development, sporulation) may be incidental noise, but the core theme is coherent. ","confidence":"Medium","size":18,"edges":10,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":4},{"id":"GO:0035751","count":3},{"id":"GO:0031321","count":3},{"id":"GO:1905279","count":3},{"id":"GO:0016601","count":3}]},{"hash":"1801629687609315903","title":"Ion and Metabolite Transmembrane Transport","description":"Most terms are specific transmembrane transport processes for ions and metabolites (malate, citrate, succinate, arsenite, sodium, potassium, monoatomic anions, etc.), pointing to membrane transporter proteins. A minor outlier is a nonsense-mediated decay term, but it does not define the cluster\u2019s primary function. ","confidence":"High","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0015743","count":5},{"id":"GO:0006814","count":5},{"id":"GO:0015700","count":5},{"id":"GO:2000185","count":5},{"id":"GO:0015746","count":5}]},{"hash":"1124530533415407532","title":"Viral integration and retrotransposon activity","description":"GO terms show viral entry, proviral latency, DNA integration, and retrotransposition/DNA transposition, indicating processes where viral genomes and transposable elements integrate and propagate in the host genome. Some terms may be noise, but the core signal is MGEs and integration activity.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":4},{"id":"GO:0006486","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2}]},{"hash":"2117312868535802286","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051028","count":4},{"id":"GO:0071456","count":4},{"id":"GO:0031954","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1695354796339719803","title":"Embryonic organogenesis and tissue morphogenesis","description":"The top GO terms point to development across multiple organs (eye, retina, habenula, lung, bone, muscle) and transcriptional regulation, suggesting these proteins participate in broad embryonic morphogenesis programs rather than a single tissue-specific function. This makes a development-focused label most representative without overfitting to one tissue.","confidence":"Medium","size":18,"edges":138,"triangles":613,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":6},{"id":"GO:0060041","count":6},{"id":"GO:0006366","count":5},{"id":"GO:0006351","count":5},{"id":"GO:2000288","count":5}]},{"hash":"1984825732717413906","title":"Post-transcriptional RNA processing and translational regulation","description":"Top GO terms point to RNA maturation and post-transcriptional control, including spliceosome-associated splicing, small-subunit processome components, mRNA stability, and various layers of translation regulation (IRES initiation, translation reinitiation) and RNA silencing. This pattern suggests a cohesive cluster of proteins involved in RNA processing and the subsequent control of gene expression at the translational level, rather than transcriptional regulation.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0035278","count":1}]},{"hash":"2104504320595181705","title":"Cardiovascular development and mitochondrial protein import","description":"The terms point to heart and vessel formation (face morphogenesis is present but less central; primary signals include myocardial precursor differentiation, cardiac muscle differentiation, and ductus arteriosus closure, plus vascular smooth muscle regulation). In parallel, there are mitochondrial protein targeting terms (protein insertion into outer membrane and protein import into the matrix), suggesting a role of mitochondria-associated processes in developing cardiovascular tissues. Some unrelated terms are present, but the dominant theme is cardiovascular development with mitochondrial import activity. Confidence: Medium","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0045040","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0003257","count":1},{"id":"GO:0097070","count":1}]},{"hash":"2126534154241155897","title":"DNA integration, recombination, and proviral latency","description":"Most terms point to DNA-level processes: replication, integration, recombination (including V(D)J recombination), and regulation of telomeric recombination, plus poly-ADP-ribosylation linked to DNA damage response. The explicit establishment of integrated proviral latency strongly ties to retroviral genome integration and maintenance. Together these suggest a theme of genome editing/maintenance with emphasis on proviral latency, hence the label. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0015074","count":2}]},{"hash":"2091798820155053146","title":"Unknown","description":"The terms are highly heterogeneous, including cell-cell signaling, renin-angiotensin\u2013related blood pressure regulation, angiotensin maturation, angiogenesis, antigen presentation, leukotriene production, symbiont entry, and development. There isn\u2019t a single cohesive theme that clearly ties these functions together, so a specific, representative label isn\u2019t evident.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007267","count":1},{"id":"GO:0003081","count":1},{"id":"GO:0002003","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0006509","count":1}]},{"hash":"1525218142451353308","title":"Unknown","description":"The top GO terms span reproductive processes, DNA processing, apoptosis, differentiation, telomere maintenance, muscle response, RNA processing, and cell migration, with no clear single function tying the proteins together.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048240","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0097194","count":2},{"id":"GO:0045444","count":2},{"id":"GO:1904355","count":2}]},{"hash":"1293064654122396871","title":"Epithelial development and ECM remodeling","description":"The cluster's top GO terms emphasize development of epithelial organs (amelogenesis, eyelid development, exocrine pancreas development) alongside extracellular matrix turnover (collagen catabolic process, ECM disassembly). This combination points to coordinated tissue formation and matrix remodeling in epithelial contexts, with signals for cell growth and epithelial-specific transport features. Therefore, the label reflects a cohesive theme of epithelial organ development coupled with ECM remodeling.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097186","count":2},{"id":"GO:0030574","count":2},{"id":"GO:0030307","count":2},{"id":"GO:0022617","count":2},{"id":"GO:0031017","count":2}]},{"hash":"2181861660455964822","title":"Plant carotenoid metabolism and light perception","description":"The cluster\u2019s top GO terms cluster around carotene/beta-carotene metabolism and vitamin A biosynthesis, plus light-detection and retinal-related processes, pointing to a shared theme of pigment metabolism linked to light sensing in plants. Some terms (retina-related, ABA) may reflect cross-species annotations or broader plant developmental/light-response roles, but the central tie is carotenoid-derived vitamin A pathways and light perception.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046760","count":2},{"id":"GO:0060042","count":1},{"id":"GO:0042574","count":1},{"id":"GO:0050908","count":1},{"id":"GO:0009688","count":1}]},{"hash":"1489295387019054484","title":"Unknown","description":"The GO terms cover lipid transport and metabolism (bile acid transport, lipoprotein and triglyceride transport, triglyceride homeostasis, cholesterol catabolic process) but also include signaling and developmental terms (peptidyl-tyrosine phosphorylation regulation, endothelial proliferation, pupariation, plant hypersensitive response, rhodopsin biosynthesis). The mix of functions and the lack of network connectivity among the proteins suggest there is no single coherent function binding the cluster, so assigning a specific label would be misleading.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050731","count":2},{"id":"GO:0015721","count":1},{"id":"GO:0009626","count":1},{"id":"GO:0070328","count":1},{"id":"GO:0016063","count":1}]},{"hash":"1523557268170533977","title":"Multisystem Development and Differentiation","description":"The terms cover morphogenesis and tissue development across multiple organs (nipple, lung, pancreas, tendon) plus related differentiation processes, with supporting regulatory activities (angiogenesis/endothelial regulation) and functional aspects (insulin secretion, plasma cell differentiation). This points to genes involved in broad developmental and differentiation programs across tissues rather than a single pathway, hence a multisystem development label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060658","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0031016","count":1},{"id":"GO:0035773","count":1},{"id":"GO:0010977","count":1}]},{"hash":"2205715741816075883","title":"Neuronal signaling and cytoskeletal remodeling","description":"The top terms include neuronal signal transduction, voltage-gated sodium channel clustering, and response to cocaine, pointing to neural signaling, while stress fiber and focal adhesion assembly and cell migration indicate cytoskeletal dynamics and adhesion. The combination suggests a functional cluster centered on signaling that regulates the cytoskeleton and adhesion in neurons and muscle contexts, though some terms are unrelated noise. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0055072","count":1},{"id":"GO:0030218","count":1},{"id":"GO:0045162","count":1},{"id":"GO:0051496","count":1}]},{"hash":"2223394534093997326","title":"Chromatin remodeling and cell cycle regulation","description":"The cluster is dominated by GO terms tied to chromatin dynamics (nucleosome disassembly, chromatin remodeling) and cell cycle control (G2/M transition, regulation of nuclear DNA replication), suggesting a cohesive role in chromatin-mediated regulation of cell cycle progression. A few metabolism/development terms are present but appear peripheral to this core theme.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001835","count":1},{"id":"GO:0000086","count":1},{"id":"GO:0006337","count":1},{"id":"GO:0033262","count":1},{"id":"GO:0031055","count":1}]},{"hash":"1254261710779393442","title":"Collagen-ECM Remodeling and Tissue Morphogenesis","description":"The top GO terms cluster around collagen fibril organization, collagen-activated signaling, endochondral ossification, and camera-type eye morphogenesis, indicating a strong theme of extracellular matrix remodeling guiding development across skeletal and ocular tissues. Some terms (complement pathways, sodium channel clustering) are less aligned with this core, but the dominant pattern is ECM- and tissue- morphogenesis\u2013related. ","confidence":"Medium","size":17,"edges":14,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":1},{"id":"GO:0033034","count":1},{"id":"GO:2000534","count":1},{"id":"GO:0038063","count":1},{"id":"GO:0001867","count":1}]},{"hash":"2046524744354900949","title":"Apoptosis-linked ER-Golgi trafficking","description":"This cluster centers on apoptotic processes (apoptotic process, recognition of apoptotic cell) and ER-Golgi transport pathways (aminophospholipid transport; COPI-coated vesicle budding; protein retention in ER lumen; positive regulation of protein exit from ER; Golgi ribbon formation), suggesting proteins linked to apoptosis and vesicular trafficking between the ER and Golgi. Some developmental and behavioral terms are present but less represented, so the core theme remains apoptosis with secretory pathway involvement.","confidence":"Medium","size":17,"edges":91,"triangles":227,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":8},{"id":"GO:0043654","count":8},{"id":"GO:0015917","count":8},{"id":"GO:0090161","count":2},{"id":"GO:0002121","count":2}]},{"hash":"2264176412108688315","title":"Endothelial cytoskeleton and vesicle trafficking regulators","description":"The cluster shows enrichment for cytoskeletal regulation (negative regulation of Rac/Rho signaling and stress fiber assembly) and centriole elongation control, alongside vesicle trafficking and Golgi/ESCRT-related processes (Golgi retention, MVB-lysosome fusion, ESCRT-mediated budding) and endothelial tube lumen extension, suggesting a coordinated role in endothelial cytoskeletal dynamics and endomembrane trafficking during morphogenesis and cell division.","confidence":"Medium","size":17,"edges":36,"triangles":28,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0035021","count":2},{"id":"GO:0035024","count":2},{"id":"GO:0051497","count":2},{"id":"GO:0097498","count":2}]},{"hash":"509184846056718266","title":"Neural development and synapse assembly","description":"Most enriched terms point to neural development and synaptic connectivity, with multiple entries for synapse assembly and its regulation, plus neuronal migration from the SVZ to the olfactory bulb and behaviors like grooming and vocalization. While a few non-neural terms (bone development, plant meristem regulation, innate immune response) appear, the strongest signal is neural development and synapse formation, which justifies a neuro-focused label. Confidence in the label is medium due to those non-neural outliers.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051965","count":3},{"id":"GO:2001013","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0009934","count":3},{"id":"GO:0045087","count":3}]},{"hash":"726616428308770823","title":"Diverse solute transmembrane transporters","description":"The top GO terms are all about transmembrane transport of a wide range of substrates (xenobiotics, nitrate/nitrite, sugars like arabinose, vitamins, sialic acid, and ions such as sodium and potassium), suggesting these proteins function as membrane transporters with broad or varied substrate specificity.","confidence":"High","size":17,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":3},{"id":"GO:0042128","count":3},{"id":"GO:1900754","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0015706","count":3}]},{"hash":"821535257975997620","title":"ER Stress and Trafficking","description":"Top GO terms cluster around endoplasmic reticulum functions, including ER localization, COPII vesicle budding, and unfolded protein response, with calcium homeostasis, suggesting a core theme of ER protein folding, quality control, and trafficking. Some terms (e.g., spliceosomal assembly, host-viral interaction terms) are less connected, likely representing outliers or dual annotations, but the dominant pattern supports an ER-centric role.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":1},{"id":"GO:0044828","count":1},{"id":"GO:0060304","count":1},{"id":"GO:0090114","count":1},{"id":"GO:0070972","count":1}]},{"hash":"1641380577660405638","title":"Immune activation and cytoskeletal remodeling","description":"The top GO terms center on immune signaling and activation (T cell costimulation, IL-2 production, dendritic cell differentiation) alongside cytoskeletal and contact processes (Rho signaling, cell\u2013cell adhesion, clustering of ion channels, sarcomere organization). This pairing suggests proteins involved in immune cell communication and the structural remodeling underlying immune synapse formation, with apoptosis regulation reflecting activation-related fate decisions. Some terms are broader (e.g., sarcomere, channel clustering) but can relate to the structural/organizational aspects of activation. ","confidence":"Medium","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:2001200","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0031295","count":3},{"id":"GO:0007157","count":3}]},{"hash":"1614562753619780516","title":"DNA replication and cell cycle checkpoints","description":"The top GO terms are dominated by DNA replication and cell cycle processes (DNA replication checkpoint signaling, replication fork arrest, mitotic intra-S checkpoint, regulation of nuclear DNA replication, sister chromatid cohesion), suggesting a cohesive theme of replication control and mitotic checkpoints; a few outliers (neuropeptide signaling, mating-type locus imprinting) may reflect annotation noise rather than true functional grouping. The absence of edges implies the proteins may share annotations without direct interactions, but the overall signal supports a replication- and cell cycle\u2013focused cluster.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0071515","count":1},{"id":"GO:0034087","count":1},{"id":"GO:0033262","count":1}]},{"hash":"1376845746043287684","title":"Neural crest-linked neural and muscle differentiation","description":"This cluster is enriched for developmental differentiation terms across neural crest derivatives and muscle lineages: cardiac neural crest development, GABAergic interneuron differentiation, astrocyte differentiation, inner ear sensory cell differentiation, somitogenesis, myoblast fate, and skeletal muscle fiber development. The common theme is coordinated programs guiding both neural crest\u2013derived neural/glial lineages and muscle formation, with transcription by RNA polymerase II as a core activity.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:2001038","count":13},{"id":"GO:0048712","count":13},{"id":"GO:0006366","count":13},{"id":"GO:0048743","count":12},{"id":"GO:0021892","count":12}]},{"hash":"1426375783348190313","title":"Cell polarity and morphogenesis","description":"Top terms center on polarity establishment (apical/basal), junction assembly, and cytoskeletal-driven morphogenesis (filopodia, wing hair organization, chaeta morphogenesis, cuticle pattern formation) plus related cell migration. While signaling terms appear, the dominant theme is development-linked morphogenesis governed by cell polarity and cytoskeleton. Label reflects this cohesive function.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007043","count":1},{"id":"GO:0032534","count":1},{"id":"GO:0035317","count":1},{"id":"GO:0071803","count":1},{"id":"GO:0035099","count":1}]},{"hash":"992882731903088128","title":"Vesicle trafficking and developmental polarity","description":"The dominant terms point to components of the secretory pathway (ER-to-Golgi transport, COPII budding, SRP-targeting) and processes that shape tissue organization (brain development, epithelial cell polarity). Additional terms related to TORC1 signaling and GTPase activity suggest growth regulation connected to trafficking. Some insect-development terms (phosphate transport, chitin-based cuticle pattern) are broader but do not eclipse the core theme.  ","confidence":"Medium","size":17,"edges":19,"triangles":1,"max_degree":5,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":4},{"id":"GO:0006888","count":4},{"id":"GO:0007420","count":4},{"id":"GO:1904263","count":4},{"id":"GO:0043547","count":4}]},{"hash":"1823441664522690328","title":"Membrane remodeling and inflammatory signaling","description":"The cluster centers on membrane dynamics and immune-related signaling: caveola assembly, membrane invagination, diapedesis, and IL-6 signaling, with supporting links to growth factor responses (PDGF, insulin signaling) and actin/cytoskeletal remodeling (formin-nucleated actin). While several terms are obsolete, the shared theme is membrane remodeling and signaling events that govern immune cell movement and activation. ","confidence":"Medium","size":17,"edges":21,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0038028","count":2},{"id":"GO:0010796","count":2},{"id":"GO:0036119","count":1},{"id":"GO:0070836","count":1},{"id":"GO:0070102","count":1}]},{"hash":"475278048971276339","title":"Wnt signaling regulation and ubiquitination","description":"Dominant GO terms are protein ubiquitination and Wnt signaling pathway (including Wnt signalosome assembly), suggesting a core theme of regulating Wnt activity via ubiquitin-mediated processes. While there are some disparate terms related to neural signaling and developmental polarity, the strongest signals point to Wnt pathway regulation through ubiquitination as the cluster\u2019s unifying function. Confidence is medium due to some heterogeneity among terms and lack of direct pathway edges.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016567","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0071287","count":1},{"id":"GO:0016336","count":1},{"id":"GO:1904887","count":1}]},{"hash":"1366744982143306301","title":"Rho-MAPK signaling and cytoskeletal remodeling","description":"Based on the dominant GO terms, the proteins cluster around signal transduction pathways (Rho signaling, MAPK activation, JUN phosphorylation) and cytoskeletal remodeling (actin cytoskeleton reorganization). While some terms are broad or obsolete, the recurring theme is signaling cascades that regulate cytoskeleton dynamics and related cellular responses, justifying this label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001525","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0031532","count":2},{"id":"GO:0014850","count":2},{"id":"GO:0060319","count":2}]},{"hash":"2049152494041744957","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":17},{"id":"GO:0000278","count":17},{"id":"GO:0006260","count":17},{"id":"GO:0006281","count":17},{"id":"GO:0060258","count":16}]},{"hash":"1453171645738740215","title":"Translation Initiation and Ribosome Biogenesis","description":"This cluster is dominated by GO terms tied to translation initiation and ribosome assembly, including translation reinitiation, formation of translation preinitiation complex, and regulation of translational initiation. Ribosome biogenesis is also prominent, aligning with the core machinery for protein synthesis. Additional terms on IRES-dependent viral translational initiation and viral termination-reinititation reinforce the focus on translation machinery, including non-canonical initiation pathways. Some terms related to cell proliferation and protein ubiquitination may reflect broader growth and protein turnover contexts, but the central theme remains translation initiation and ribosome biogenesis.","confidence":"High","size":17,"edges":14,"triangles":0,"max_degree":4,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":5},{"id":"GO:0001731","count":5},{"id":"GO:0008283","count":4},{"id":"GO:0042254","count":3},{"id":"GO:0032933","count":3}]},{"hash":"1077078527069778571","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":94,"triangles":301,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":11},{"id":"GO:0000398","count":8},{"id":"GO:0090503","count":7},{"id":"GO:1902416","count":7},{"id":"GO:0070935","count":7}]},{"hash":"339796351236309385","title":"Synaptic organization and NMDA signaling in retina/brain","description":"This cluster centers on synaptic structure and function: terminal button organization, synaptic vesicle clustering, and receptor internalization, together with regulation of NMDA receptor activity. The retina development term suggests involvement in retinal synaptic wiring, aligning with neural/synaptic roles in the brain and eye. Additional terms about xenobiotic response and circadian wakefulness reflect broader neuronal responsiveness but do not override the core synaptic theme.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060041","count":8},{"id":"GO:0042136","count":7},{"id":"GO:2000310","count":7},{"id":"GO:0042493","count":7},{"id":"GO:0008285","count":7}]},{"hash":"1142703577783743414","title":"Cell cycle ubiquitin-mediated proteolysis","description":"This cluster is dominated by GO terms for ubiquitin-dependent protein degradation mediated by SCF and APC complexes (K11-linked ubiquitination; SCF-dependent proteasomal ubiquitin-dependent degradation) and anaphase-promoting complex activity, indicating cell cycle\u2013regulated proteolysis. Additional terms touch DNA replication and transcription-related regulation, suggesting these proteins coordinate protein turnover with DNA metabolism and gene expression. Overall, a module centered on cell-cycle control via ubiquitin-proteasome pathways, with links to DNA replication and transcription processes.","confidence":"Medium","size":17,"edges":21,"triangles":13,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0031145","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0007568","count":2}]},{"hash":"1808885832748001251","title":"ER-Golgi vesicle transport and microtubule-based movement","description":"This cluster centers on intracellular transport between the ER and Golgi, plus broader vesicle trafficking and microtubule-driven processes, including retrograde transport, mRNA transport, and mitotic spindle-related activities. The convergence of terms for ER-Golgi trafficking, intracellular transport, and microtubule-based movement supports a cohesive role in cytoskeletal-assisted vesicle movement and cell division.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0007584","count":3},{"id":"GO:0090307","count":3},{"id":"GO:0006886","count":2},{"id":"GO:0051301","count":2}]},{"hash":"758832064378078368","title":"Unknown","description":"Unknown","confidence":"","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042311","count":1},{"id":"GO:0070121","count":1},{"id":"GO:0021756","count":1},{"id":"GO:0045494","count":1},{"id":"GO:1903441","count":1}]},{"hash":"685279747527691748","title":"Golgi\u2013ER and Vacuolar Vesicle Transport","description":"This cluster shows a clear signal for vesicle trafficking and intracellular transport: retrograde transport between endosomes, Golgi, and ER; Golgi-to-vacuole transport; protein targeting to vacuole; and synaptic vesicle budding, all pointing to a vesicle delivery/trafficking theme. Some terms like DNA integration, keratinocyte differentiation, and angiogenesis appear as noise, but the dominant pattern is vesicle transport involving Golgi and vacuolar pathways.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0030216","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0032515","count":1},{"id":"GO:0016185","count":1}]},{"hash":"144106969165750924","title":"Nematode development and reproduction","description":"The top GO terms cluster around nematode-specific developmental and reproductive processes: pharyngeal pumping, molting/cuticle formation, embryonic morphogenesis and axis specification, proteolysis, and reproductive interactions (prevention of polyspermy, sperm binding to zona pellucida). A few terms (neuronal paranode localization, anthocyanin biosynthesis) are less cohesive, but the dominant pattern supports a cohesive theme of nematode development and reproductive biology.","confidence":"Medium","size":17,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":5},{"id":"GO:0018996","count":5},{"id":"GO:0060468","count":4},{"id":"GO:0048632","count":4},{"id":"GO:2000360","count":4}]},{"hash":"307064985184033742","title":"Retroviral integration and proviral latency","description":"Most terms describe steps in a retroviral life cycle: entry into the host cell, integration of viral DNA into the host genome, reverse transcription (RNA-templated DNA synthesis), DNA replication, and establishment of proviral latency, with additional hints of host antiviral RNAi modulation. This cohesive theme supports a retroviral/proviral interpretation for the cluster.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":4},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1223536300252486728","title":"Mammary gland and adipocyte differentiation","description":"This cluster centers on GO terms for mammary gland alveolus development and mammary gland epithelial cell proliferation, as well as fat cell differentiation and related metabolic signaling, suggesting a developmental program focused on mammary/adipose tissue differentiation. Other terms (e.g., limb development, transcription, cell division) may reflect broader shared developmental processes or housekeeping functions, but the strongest signals align with mammary and adipose differentiation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060749","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0033327","count":4},{"id":"GO:0046626","count":3},{"id":"GO:0045444","count":3}]},{"hash":"428615982832371997","title":"Plant far-red light signaling and circadian regulation","description":"The terms include clear signals of plant-specific light sensing (far-red light signaling pathway; red, far-red light phototransduction) and a link to circadian rhythm regulation, suggesting a cohesive theme around light-driven temporal gene expression. Additional terms related to transcription/translation regulation fit downstream control, while ROS and stress-related responses may reflect light-associated stress responses. Overall, the cluster appears to group proteins involved in plant light signaling and circadian regulation, with secondary roles in gene expression and stress response. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":2},{"id":"GO:0046898","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0042753","count":1}]},{"hash":"1705218269421796263","title":"Embryonic organ development","description":"The top GO terms cluster around developmental processes across multiple organs and tissues (lung mesenchyme, somite, heart development, branching morphogenesis of salivary gland, multicellular organism development), suggesting a broad role in embryogenesis and organ formation. The presence of some transport terms (sialic acid transport; UDP-N-acetylglucosamine transmembrane transport) may reflect ancillary metabolic or membrane-associated functions but do not negate the overarching developmental theme. Overall, the proteins together appear linked to embryonic development and organogenesis rather than a single specific pathway, making this a coherent label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060484","count":2},{"id":"GO:0002320","count":2},{"id":"GO:0061053","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0060445","count":2}]},{"hash":"1048689414068966785","title":"Nematode molting and pharyngeal feeding","description":"The top GO terms point to nematode-specific biology: a molting cycle involving collagen/cuticle and nematode pharyngeal pumping, suggesting development and feeding processes. Other terms are sparse or obsolete, adding noise, but the strongest signals are tied to nematode cuticle/molt biology and feeding. This supports a label centered on nematode development and feeding rather than a broader, unified function.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1},{"id":"GO:2000217","count":1},{"id":"GO:1900375","count":1},{"id":"GO:1900526","count":1}]},{"hash":"2044730951363730194","title":"Neuropeptide signaling and pain perception","description":"This cluster is enriched for neuropeptide signaling and sensory perception of pain (GO:0007218 and GO:0019233, 3 each), suggesting a neural signaling theme. Additional terms related to retina development, axon diameter regulation, GTPase activity, and cytokine response support a broader neural communication context rather than a metabolic one, but the dominant signal is neural signaling linked to pain perception.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0008283","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0060041","count":2}]},{"hash":"2063592864019385876","title":"Drosophila Tracheal and Wing Morphogenesis","description":"The top GO terms cluster around tracheal development (outgrowth, pit formation) and imaginal disc\u2013derived wing expansion, with supporting signaling pathways (Rap, ERK) typical of developmental morphogenesis in Drosophila. Some outliers (trophoblast migration, phototaxis) may reflect broad or cross-species annotations, but the dominant theme is fly tracheal/wing morphogenesis.","confidence":"Medium","size":16,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060232","count":2},{"id":"GO:1903984","count":2},{"id":"GO:0032487","count":2},{"id":"GO:0007426","count":2},{"id":"GO:1901164","count":2}]},{"hash":"264301439884756596","title":"Synaptic vesicle exocytosis and actin remodeling","description":"This cluster appears centered on neuronal vesicle trafficking and cytoskeletal dynamics. The prominent GO terms\u2014regulation of synaptic vesicle exocytosis, positive regulation of actin polymerization, and actin cable assembly\u2014point to coordinated neurotransmitter release with actin remodeling. Additional signals for cytoplasmic translation and ribosomal subunit export suggest local protein synthesis at synapses as part of remodeling. Some terms may be broader or less directly related, but the core theme ties vesicle dynamics to actin-driven structural changes in neurons.","confidence":"High","size":16,"edges":73,"triangles":128,"max_degree":12,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:2000300","count":5},{"id":"GO:0043524","count":4},{"id":"GO:0000060","count":4},{"id":"GO:0071806","count":4},{"id":"GO:0002181","count":4}]},{"hash":"1054819188684564120","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":116,"triangles":507,"max_degree":15,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":13},{"id":"GO:0031047","count":12},{"id":"GO:0000464","count":9},{"id":"GO:0006260","count":9},{"id":"GO:0031124","count":8}]},{"hash":"595983439920107812","title":"Unknown","description":"The GO terms are spread across diverse biological processes (muscle development, RNA splicing, sumoylation, meiosis, membrane potential, DNA damage response, nuclear envelope interactions, keratinocyte apoptosis, and androgen signaling), with little clear overlap, so there isn\u2019t a single coherent theme to label confidently.","confidence":"","size":16,"edges":81,"triangles":189,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0045843","count":1},{"id":"GO:0006376","count":1},{"id":"GO:0033235","count":1},{"id":"GO:1990466","count":1},{"id":"GO:0043060","count":1}]},{"hash":"1336670351273368093","title":"ECM Organization and Tissue Morphogenesis","description":"The top GO terms cluster around extracellular matrix and connective tissue development: collagen fibril organization, skin morphogenesis, and endochondral ossification, plus collagen-activated signaling. While there are some immune-related terms (complement activation), the dominant pattern is extracellular matrix remodeling and tissue morphogenesis, suggesting a coherent ECM/Development theme for the proteins in this cluster.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043589","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3},{"id":"GO:0038063","count":3}]},{"hash":"1244318871811435062","title":"Spindle assembly and chromosome segregation","description":"The cluster is dominated by GO terms describing the mitotic spindle and its dynamics: spindle assembly, centrosome separation, spindle elongation, kinetochore microtubule attachment, and chromosome recapture during metaphase. These functions point to a shared role in organizing the spindle apparatus for accurate chromosome segregation, with one outlier term related to cerebellar granular layer structure that doesn\u2019t outweigh the mitotic theme.","confidence":"High","size":16,"edges":67,"triangles":174,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0048364","count":16},{"id":"GO:0051296","count":16},{"id":"GO:0021685","count":16},{"id":"GO:0007100","count":16},{"id":"GO:1990942","count":16}]},{"hash":"1203058414948223051","title":"RNA processing and splicing machinery","description":"This cluster is dominated by GO terms for transcription termination, tRNA and rRNA maturation, spliceosome and snRNP assembly, and mRNA splicing, indicating a cohesive RNA metabolism and processing theme with related nuclear import. A few outliers (e.g., hair cycle) appear as noise, but the core signal centers on RNA processing and splicing.","confidence":"High","size":16,"edges":105,"triangles":390,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006369","count":6},{"id":"GO:0008033","count":5},{"id":"GO:0030490","count":5},{"id":"GO:0009414","count":4},{"id":"GO:0000245","count":4}]},{"hash":"1635115353327347313","title":"Synaptic plasticity and light-sensing signaling","description":"This cluster centers on neuronal synaptic modulation and light-responsive signaling, with enrichment for regulation of short-term synaptic plasticity, long-term synaptic depression, excitatory postsynaptic potentials, and positive regulation of synaptic transmission. It also includes terms tied to visual perception and light-stimulus detection (phototaxis), along with posterior lateral line development, a fish sensory system, suggesting a theme of sensory-neural signaling connected to light sensing. While a few terms are broad (e.g., receptor internalization, sodium ion transport), the dominant pattern points to a module of synaptic signaling intertwined with light-sensing in a vertebrate sensory context.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048172","count":3},{"id":"GO:0060292","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0050806","count":2},{"id":"GO:0050908","count":2}]},{"hash":"1203644181488522140","title":"Mitochondrial respiration and protein handling","description":"The top GO terms cluster around mitochondrial functions: electron transport and aerobic respiration, assembly of respiratory complexes, and mitochondrial protein handling including import, translation within the organelle, and protein folding. This coherence strongly suggests a mitochondria-centered cluster focused on energy metabolism and mitochondrial protein homeostasis, with a few peripheral terms like DNA repair and diadenosine pentaphosphate catabolism being less central. ","confidence":"High","size":16,"edges":115,"triangles":496,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006123","count":3},{"id":"GO:1902600","count":3},{"id":"GO:0006281","count":2},{"id":"GO:0097250","count":1},{"id":"GO:0009060","count":1}]},{"hash":"95922521795754047","title":"Mitochondrial Translation and Respiratory Chain","description":"Most terms point to mitochondrial function: translation in mitochondria, import into the mitochondrial matrix, electron transport chain steps, and assembly of cytochrome complexes, with support from autophagy of mitochondrion and regulation of cellular respiration. Together these imply a mitochondrial biogenesis/respiration theme, justifying the name.","confidence":"High","size":16,"edges":119,"triangles":546,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0009060","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0006121","count":1},{"id":"GO:0006099","count":1}]},{"hash":"1785973042458274266","title":"Mitochondrial transport and energy metabolism","description":"The cluster shows a coherent set of mitochondrial-focused functions: nucleotide, cofactor (thiamine pyrophosphate), and heme transport across mitochondrial membranes; the malate-aspartate shuttle; mitochondrial ATP transport; and regulation of mitochondrial membrane potential. Additional terms like fatty-acid response, IGF signaling, and necroptosis regulation fit the broader theme of mitochondrial energy metabolism and cell survival. While a few terms are tangential, the dominant pattern points to mitochondrial transport/energy processes.","confidence":"High","size":16,"edges":16,"triangles":1,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0070542","count":8},{"id":"GO:1990519","count":4},{"id":"GO:0007565","count":4},{"id":"GO:0043490","count":4},{"id":"GO:1990544","count":4}]},{"hash":"57274998046589080","title":"RNA processing and translational regulation","description":"These terms cluster around RNA metabolism and control of translation: translation reinitiation and preinitiation complex formation point to translation initiation; IRES-dependent translation and miRNA-mediated silencing reflect regulation of protein synthesis; mRNA stabilization and polyadenylation relate to RNA stability; and splicing regulation plus small-subunit processome assembly indicate broader RNA processing. Together they suggest a functional group focused on RNA processing and translational regulation.","confidence":"High","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0010610","count":5},{"id":"GO:0034462","count":4},{"id":"GO:0075522","count":4}]},{"hash":"1840301646860273276","title":"Hormone-responsive growth signaling","description":"This cluster features signaling and hormone-related terms: cellular response to insulin stimulus, response to estradiol, and Notch signaling, coupled with DNA-templated transcription, suggesting downstream transcriptional regulation of growth in response to hormonal cues. The metabolic catabolic terms are present but secondary, tying into overall metabolic regulation that supports growth signaling.","confidence":"Medium","size":16,"edges":24,"triangles":17,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0032869","count":4},{"id":"GO:0040008","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0042853","count":3},{"id":"GO:0007219","count":3}]},{"hash":"1559448482478662030","title":"Unknown","description":"The top GO terms are heterogeneous (sensory signaling, GPCR regulation, various developmental processes across species) with no clear shared function or interaction pattern (no edges/triangles). There isn\u2019t a cohesive theme to tie the proteins together, so a descriptive unknown label is appropriate.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":1},{"id":"GO:0071870","count":1},{"id":"GO:0000750","count":1},{"id":"GO:0072513","count":1},{"id":"GO:0048527","count":1}]},{"hash":"169503980647024764","title":"Nitric Oxide Signaling and Blood Pressure Regulation","description":"The terms cluster around nitric oxide biology\u2014NO transport, NO biosynthetic regulation, nitrosative stress response, and a link to blood pressure regulation\u2014pointing to a NO-centered vascular signaling theme. Peripheral terms like erythrocyte maturation and bicarbonate transport may reflect broader annotation context rather than core function. Overall, NO signaling and vascular regulation best captures the cluster\u2019s shared function.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":3},{"id":"GO:0032966","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0051409","count":2},{"id":"GO:0045429","count":2}]},{"hash":"1743743119644808558","title":"ECM organization and connective tissue remodeling","description":"This cluster centers on collagen fibril organization, skeletal system development, osteoblast proliferation, fibroblast migration, and integrin signaling, with supporting terms on smooth muscle and angiogenesis regulation. Together these indicate extracellular matrix-dominated tissue formation and remodeling in connective tissues and vasculature, including bone and muscle components and angiogenic control.","confidence":"Medium","size":16,"edges":57,"triangles":86,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:2001027","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0048661","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1493743181444040730","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":52,"triangles":49,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":14},{"id":"GO:0048701","count":14},{"id":"GO:0006281","count":14},{"id":"GO:0060258","count":13},{"id":"GO:0010825","count":13}]},{"hash":"915288573493331131","title":"DNA Repair and Genome Maintenance","description":"Top GO terms indicate multiple DNA repair pathways and recombination processes (SSA, NER in interstrand cross-link repair, BIR), meiotic recombination regulation, DNA damage checkpoints, and telomere protection, which collectively point to genome integrity maintenance. Some stress response terms appear but are peripheral to the dominant repair/recombination theme.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":1},{"id":"GO:0010507","count":1},{"id":"GO:0000736","count":1},{"id":"GO:0010520","count":1},{"id":"GO:1901255","count":1}]},{"hash":"93449263487149481","title":"Embryonic patterning and tissue morphogenesis","description":"The cluster\u2019s top GO terms cluster around embryonic development and patterning (left/right pattern formation, heart development via EMT in endocardial cushion formation, placental and endocrine system development, cartilage morphogenesis, and trophoblast differentiation). While a couple of terms touch on general RNA processing, the dominant signal is embryogenesis and tissue morphogenesis, suggesting these proteins participate in developmental patterning and organogenesis rather than a single specific pathway. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060972","count":2},{"id":"GO:0003198","count":2},{"id":"GO:0060806","count":2},{"id":"GO:0003323","count":2},{"id":"GO:0000055","count":2}]},{"hash":"2280856575607881408","title":"Embryonic organ morphogenesis","description":"The proteins map to multiple embryonic development and morphogenesis GO terms (eye, heart, placenta, habenula, prostate, etc.) and include related signaling and proliferation regulation, suggesting a general role in embryonic organ formation rather than a single tissue function.","confidence":"High","size":16,"edges":55,"triangles":46,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":9},{"id":"GO:0007507","count":9},{"id":"GO:2000288","count":9},{"id":"GO:0060527","count":9},{"id":"GO:0055010","count":9}]},{"hash":"1723604719278130671","title":"Zinc Homeostasis and Transport","description":"This cluster is dominated by GO terms related to zinc handling: import across membranes, intracellular zinc ion homeostasis, and detoxification, plus a response to zinc ion starvation. These associations point to a cohesive role in zinc uptake, regulation, and buffering within cells, with metal transport (including cadmium) as a related theme. The limb development and ossification terms may reflect zinc's involvement in bone biology but do not override the central zinc metabolism signal.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":1},{"id":"GO:0006830","count":1},{"id":"GO:0044749","count":1},{"id":"GO:1903615","count":1},{"id":"GO:0006882","count":1}]},{"hash":"949182558968851324","title":"Unknown","description":"The GO terms span immune/coagulation-related proteolysis (complement activation pathways, Factor XII activation) alongside diverse processes like midbrain and biomineral tissue development, transcription regulation, glucose response, and blood pressure regulation, with no evident single dominant function or interaction pattern (and zero edges/triangles). This broad, multi-process mix makes a cohesive label unlikely.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":4},{"id":"GO:0000122","count":3},{"id":"GO:0030901","count":3},{"id":"GO:0071333","count":2},{"id":"GO:0003050","count":2}]},{"hash":"334749982725373715","title":"Adhesion and migration in muscle and neural development","description":"The top GO terms cluster around cell adhesion (homophilic cell-cell adhesion, receptor clustering, substrate adhesion-dependent spreading) and cellular migration/guidance (lateral motor column neuron migration, dopaminergic neuron axon guidance), with supporting roles in muscle satellite cell activation/differentiation and adipocyte differentiation. This suggests a coherent theme of adhesion-mediated remodeling during development in muscle and nervous system, with some related differentiation processes.","confidence":"Medium","size":16,"edges":111,"triangles":442,"max_degree":15,"top_function":"wound healing","top_go_terms":[{"id":"GO:0070527","count":8},{"id":"GO:0097477","count":8},{"id":"GO:0014719","count":6},{"id":"GO:0043654","count":6},{"id":"GO:0050873","count":6}]},{"hash":"606326883339139209","title":"Protein and polyamine acetylation","description":"The cluster is dominated by acetylation-related GO terms, including peptidyl-lysine N6-acetylation, N-terminal peptidyl-methionine acetylation, histone H4 acetylation, and spermidine/spermine acetylation, with additional catabolic processes that can connect to acetylation metabolism. This creates a cohesive theme around acetylation modifications affecting proteins and polyamines, possibly linked to gene regulation via histone acetylation in plants.","confidence":"High","size":16,"edges":118,"triangles":532,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0018003","count":15},{"id":"GO:0009447","count":14},{"id":"GO:0032918","count":14},{"id":"GO:0045150","count":14},{"id":"GO:2000025","count":14}]},{"hash":"1378985398630091671","title":"Fungal Recognition and Innate Immune Signaling","description":"Based on the top GO terms, the cluster centers on activation and signaling of innate immune cells in response to fungal components: basophil activation; lectin pathway complement activation; C-type lectin receptor signaling; Fc-gamma receptor signaling; phagocytosis recognition; and cellular response to fungal origin. Some terms related to oxidative stress and arachidonic acid secretion support inflammatory processes. A few items about kidney morphogenesis appear unrelated, suggesting possible annotation noise. Overall, the dominant immune-related signals support labeling as innate immune signaling in response to fungi.","confidence":"Medium","size":16,"edges":62,"triangles":123,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":14},{"id":"GO:0001867","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0038094","count":14},{"id":"GO:0090403","count":14}]},{"hash":"703681401900625795","title":"Unknown","description":"Top terms are a mix of cytoskeleton-related processes (filopodium assembly, its regulation, TORC2 signaling, integrin activation) and unrelated terms (heart development, cardiac contraction, sterol biosynthesis, glucose transport, antigen receptor signaling). There is no single clear function unifying all proteins, so a confident, specific label cannot be assigned. ","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051489","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0038203","count":1},{"id":"GO:0016126","count":1},{"id":"GO:0050851","count":1}]},{"hash":"1409438700818537344","title":"Unknown","description":"The top GO terms span diverse developmental and tissue contexts (insect leg patterning, mammary gland development, Schwann/oligodendrocyte differentiation) and general signaling processes, with little or no shared pathway or function across the cluster. There isn\u2019t a cohesive theme to justify a more specific label, so Unknown with no confidence is appropriate.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000010","count":1},{"id":"GO:0007479","count":1},{"id":"GO:2000252","count":1},{"id":"GO:2000366","count":1},{"id":"GO:0045429","count":1}]},{"hash":"876498266173502160","title":"Peptide Processing and Renin-Angiotensin Regulation","description":"The top GO terms cluster around proteolytic processing of peptides and proteins (autoprocessing, angiotensin maturation, digestion, antigen processing via MHC II) and hormonal regulation via the renin-angiotensin system (angiotensin maturation, regulation of blood volume, aldosterone production, drinking behavior). This points to a theme of peptide/protein processing linked to endocrine and fluid-balance control, with a secondary signal from immune-related processing that may reflect shared proteolytic activities. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016540","count":2},{"id":"GO:0019886","count":2},{"id":"GO:0002803","count":2},{"id":"GO:0001823","count":2},{"id":"GO:0007586","count":2}]},{"hash":"1473059682004455228","title":"Ion and Metabolite Transmembrane Transporters","description":"The top GO terms are largely about transmembrane transport of diverse substrates\u2014potassium, sodium, nitrate/nitrite, arabinose, 4-hydroxyphenylacetate, vitamins, and xenobiotics\u2014suggesting a cluster of membrane transporter proteins handling ions and various metabolites. Fucose metabolic process appears as a linked pathway rather than the primary function, reinforcing a transporter-focused grouping.","confidence":"Medium","size":16,"edges":18,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006004","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0006855","count":5},{"id":"GO:0042128","count":5},{"id":"GO:1900754","count":5}]},{"hash":"466833560152370951","title":"Insect antennal and compound eye development","description":"The top GO terms strongly point to development of sensory organs, with antennal development and compound eye development highlighted, plus associated CNS formation and transcriptional regulation, suggesting a developmental program for insect sensory organs and neural tissues; other metabolic terms likely reflect membrane remodeling during development but do not override the overarching theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007469","count":2},{"id":"GO:0006687","count":2},{"id":"GO:0019388","count":2},{"id":"GO:0042340","count":2},{"id":"GO:0006355","count":2}]},{"hash":"2020002733977456080","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":2},{"id":"GO:0010587","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0000398","count":1}]},{"hash":"379517359069571294","title":"Nematode Development and Morphogenesis","description":"These terms cluster around nematode developmental biology, including pharyngeal function, molting and cuticle formation, embryonic morphogenesis, axis specification, and reproductive/neural development, suggesting the proteins collectively participate in nematode development and morphogenesis.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043050","count":6},{"id":"GO:0018996","count":6},{"id":"GO:2000360","count":5},{"id":"GO:0007313","count":5},{"id":"GO:0006508","count":5}]},{"hash":"2165789392926256898","title":"Peptide hormone processing and vascular regulation","description":"The top GO terms cluster around processing and regulation of peptide hormones and vascular-related pathways, including insulin processing, bradykinin catabolism, fibrinolysis, and angiotensin level regulation. Additional terms on endosomal vesicle fusion and glucose response connect to secretory trafficking and metabolic signaling, suggesting a group of proteins involved in peptide hormone maturation and modulation of vascular homeostasis, even though there are no reported interactions within the cluster.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034058","count":1},{"id":"GO:0071333","count":1},{"id":"GO:0009408","count":1},{"id":"GO:0002002","count":1},{"id":"GO:0035611","count":1}]},{"hash":"2164930358115440875","title":"K11-linked Ubiquitination in Mitosis and Embryogenesis","description":"Top GO terms indicate a cohesive theme of ubiquitin-dependent regulation, especially K11-linked ubiquitination, paired with mitotic cell cycle control (G1/S transition) and embryonic development processes. This points to a functional cluster where ubiquitin signaling orchestrates cell division and developmental timing, with some peripheral terms reflecting broader roles in development and chromatin modification. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070979","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0040016","count":1},{"id":"GO:2000001","count":1},{"id":"GO:0000082","count":1}]},{"hash":"2022028472718700892","title":"Nuclear mRNA Surveillance and Decay","description":"The cluster is dominated by GO terms for nuclear mRNA decay and surveillance (nonsense-mediated decay, non-stop decay, exonucleolytic decay, mRNA export and stability regulation), indicating a cohesive role in RNA quality control and processing in the nucleus. A single telomerase-related term appears incidental.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070481","count":1},{"id":"GO:0070651","count":1},{"id":"GO:0071042","count":1},{"id":"GO:0000184","count":1},{"id":"GO:0016973","count":1}]},{"hash":"2300758149895491913","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008542","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0001843","count":2},{"id":"GO:0031571","count":2},{"id":"GO:0006695","count":2}]},{"hash":"1124492393999189669","title":"Ubiquitin-mediated proteolysis in meiosis and oocyte maturation","description":"The cluster centers on ubiquitin-dependent protein catabolic processes and polyubiquitination, with clear ties to meiosis-related events (spindle assembly in female meiosis I) and oocyte maturation, indicating a role in cell-cycle regulation during development. Some terms hint at broader developmental processes, but the dominant signal is protein degradation controlled by ubiquitination in meiotic/oocyte contexts.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0000209","count":3},{"id":"GO:0008285","count":3},{"id":"GO:0046785","count":3},{"id":"GO:0070544","count":3}]},{"hash":"1876726247663786145","title":"Sphingolipid metabolism and inflammatory signaling","description":"The cluster\u2019s most representative terms point to sphingolipid pathways (sphingosine and phytosphingosine biosynthesis) and inflammatory response, suggesting a theme around lipid-mediated signaling linked to inflammation. Other terms such as cortisol regulation and brain-related processes are present but less central, so the core label emphasizes sphingolipid metabolism coupled with inflammatory signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000064","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0006671","count":1},{"id":"GO:0006954","count":1},{"id":"GO:0046512","count":1}]},{"hash":"807472159152416378","title":"Eye and Olfactory Development","description":"Based on the top GO terms, the strongest signals are sensory perception of chemical stimuli and camera-type eye morphogenesis, suggesting a cluster centered on sensory organ development (eye) and olfactory sensing. Other terms point to general cellular processes, but the primary theme remains sensory system development.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050907","count":2},{"id":"GO:0048593","count":2},{"id":"GO:0042048","count":1},{"id":"GO:0006516","count":1},{"id":"GO:0021993","count":1}]},{"hash":"1091214467828479102","title":"Dopaminergic signaling and visual perception","description":"The cluster has strong ties to neural signaling and visual function, with terms like dopaminergic synaptic transmission, behavioral response to cocaine, visual perception/learning, and ERK cascade regulation pointing to dopamine-mediated neural processing and vision. A few non-neural terms (heart development, macrophage chemotaxis) appear but do not outweigh the dominant neural/visual theme, justifying a neural/vision\u2013focused label.","confidence":"Medium","size":15,"edges":9,"triangles":2,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0008285","count":9},{"id":"GO:0007507","count":8},{"id":"GO:0048148","count":8},{"id":"GO:0010759","count":8},{"id":"GO:0070374","count":8}]},{"hash":"1650701473707022902","title":"Multisubstrate membrane transporters","description":"The top GO terms indicate transport across membranes for xenobiotics, vitamins, sugars (glucose, trehalose, lactose), phosphate, and other substrates, plus osmotic stress response, all pointing to a cluster of membrane transporter proteins with diverse substrates rather than a single substrate class. This justifies a label describing multisubstrate membrane transport activity.","confidence":"High","size":15,"edges":87,"triangles":278,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":13},{"id":"GO:0035461","count":13},{"id":"GO:0042908","count":8},{"id":"GO:0006817","count":8},{"id":"GO:0015771","count":8}]},{"hash":"2111063689682952463","title":"Neural signaling and sensory perception","description":"The top GO terms cluster around brain-related functions: dopaminergic synaptic transmission, visual perception and learning, cerebellar cortex formation, sensory perception of pain, and behavior related to cocaine, indicating a brain-focused module of neural signaling and sensory processing. While a couple of terms touch on immune or inflammatory responses, the dominant pattern supports neural signaling and sensory pathways.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009636","count":8},{"id":"GO:0007507","count":7},{"id":"GO:0048148","count":7},{"id":"GO:0010759","count":7},{"id":"GO:0008542","count":7}]},{"hash":"1682032011999270533","title":"Neural development and axon guidance","description":"This cluster centers on nervous system development, ROBO roundabout signaling, corpus callosum formation, and neuronal signaling elements (e.g., clustering of voltage-gated potassium channels), indicating a cohesive theme of neural development and axon guidance. Some terms (heart development, prostate signaling) are less connected, but the dominant signal is neural development.","confidence":"High","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0035385","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0050852","count":9},{"id":"GO:0022038","count":8},{"id":"GO:0006032","count":8}]},{"hash":"570357170966051419","title":"Organogenesis and inflammatory signaling","description":"The GO terms are dominated by diverse developmental processes across multiple tissues (limb bud, cardiogenic plate, chondrocyte hypertrophy, cornea, mammary and Harderian glands, endothelial proliferation), indicating organogenesis programs. Intersecting these are immune-related terms (TNF production, IL-1\u03b2 production, dendritic cell differentiation), suggesting concurrent inflammatory signaling. This combination points to a cluster centered on development with linked inflammatory/cytokine activity.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060174","count":1},{"id":"GO:0003415","count":1},{"id":"GO:2001200","count":1},{"id":"GO:1990774","count":1},{"id":"GO:0001935","count":1}]},{"hash":"148893721199611035","title":"Developmental ECM Remodeling and Complement Activation","description":"The top GO terms cluster around collagen fibril organization, cuticle development, and ossification, all pointing to extracellular matrix remodeling during development and organogenesis. Complement activation terms (classical and lectin pathways) appear alongside these developmental notes, suggesting an ancillary immune signaling role within the same protein set. Overall, the cluster seems to reflect ECM-mediated development with some involvement of immune pathways.","confidence":"Medium","size":15,"edges":36,"triangles":30,"max_degree":10,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0040032","count":4},{"id":"GO:0042338","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3}]},{"hash":"2176367022982939332","title":"Vesicle trafficking and protein targeting","description":"The terms cluster around intracellular transport and routing of proteins \u2014 Golgi retention, vesicle-mediated transport, lysosome targeting, MVB sorting, exosome assembly, and vacuolar targeting \u2014 indicating a cohesive theme of vesicle trafficking within secretory and endolysosomal pathways, with some peripheral signaling terms as less central context.","confidence":"High","size":15,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009736","count":2},{"id":"GO:0045053","count":2},{"id":"GO:1903551","count":2},{"id":"GO:0031321","count":2},{"id":"GO:0043328","count":2}]},{"hash":"518146574993463477","title":"Diverse Membrane Transporters","description":"GO terms indicate transmembrane transport of a wide range of substrates, including xenobiotics, nitrate/nitrite, sugars, vitamins, and various ions, implying these proteins function primarily as transporters. The unifying theme is membrane transport of diverse metabolites and ions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0015706","count":2}]},{"hash":"233240966565005835","title":"Chromatin remodeling and cytoskeletal organization","description":"The cluster\u2019s top terms point to chromatin-related processes (histone acetylation, DNA duplex unwinding) alongside cytoskeletal and cell architecture functions (sarcomere organization, establishment/maintenance of cell polarity, shape regulation). While there are broader cell-physiology terms (retina homeostasis, calcium response), the combination suggests a shared theme around epigenetic regulation paired with cytoskeletal structure and polarity. ","confidence":"Medium","size":15,"edges":84,"triangles":256,"max_degree":14,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0032508","count":11},{"id":"GO:0043982","count":6},{"id":"GO:1904623","count":6},{"id":"GO:0043983","count":6},{"id":"GO:0045214","count":6}]},{"hash":"2121431425635007762","title":"Unknown","description":"The GO terms span embryonic development, epithelial polarity, immune differentiation, signaling cascades, and plant morphogenesis, with no dominant shared function.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043923","count":1},{"id":"GO:0035778","count":1},{"id":"GO:0001756","count":1},{"id":"GO:0048281","count":1},{"id":"GO:0016332","count":1}]},{"hash":"1071080293331068590","title":"Innate immune signaling and autophagy","description":"The top GO terms show strong representation of innate immune responses to bacteria and dsRNA, including LPS signaling, defense against Gram-positive bacteria, and xenophagy, suggesting the cluster centers on immune-defense pathways; a few terms about cerebellar development and synapse assembly are present but appear less connected to the dominant theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":13},{"id":"GO:0046826","count":13},{"id":"GO:0000278","count":12},{"id":"GO:0050830","count":12},{"id":"GO:1904417","count":12}]},{"hash":"1682939620809807157","title":"Amino acid and tetrapyrrole metabolism","description":"The proteins appear enriched for amino acid metabolism (putrescine, proline, beta-alanine, GABA) and tetrapyrrole/pigment biosynthesis (protoporphyrinogen IX, chlorophyll), suggesting a core theme around amino acid and porphyrin/tetrapyrrole biosynthesis. Some terms like behavioral responses are likely annotation spillover, but the dominant signal aligns with metabolic pathways. ","confidence":"Medium","size":15,"edges":12,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009447","count":2},{"id":"GO:0015995","count":2},{"id":"GO:0048148","count":2},{"id":"GO:0006782","count":2},{"id":"GO:0010121","count":2}]},{"hash":"1502599010088978172","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":40,"triangles":56,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006370","count":3},{"id":"GO:0002181","count":2},{"id":"GO:0000453","count":2},{"id":"GO:0097310","count":2},{"id":"GO:0039654","count":2}]},{"hash":"449560328795639238","title":"Mitochondrial Transport and Membrane Potential","description":"The proteins cluster around transport of various metabolites into mitochondria (pyrimidine nucleotides, coenzyme A, thiamine pyrophosphate, heme), involvement in the malate-aspartate shuttle, and mitochondrial ATP transmembrane transport, plus regulation of mitochondrial membrane potential. While there are also signals related to IGF stimulation and necroptosis regulation, the common thread is mitochondrial metabolite transport and energetic regulation.","confidence":"High","size":15,"edges":11,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":2},{"id":"GO:0007565","count":2},{"id":"GO:0043490","count":2},{"id":"GO:1990544","count":2},{"id":"GO:0030974","count":2}]},{"hash":"540350374541447694","title":"Multisystem Signaling and Behavior Regulation","description":"The cluster includes GO terms spanning immune signaling (phosphorylation, T cell receptor signaling, TNFSF11 signaling, MAPK regulation), epithelial/endothelial barrier/polarity establishment, and neural/behavioral processes (grooming and vocalization), plus a metabolic biosynthesis term. This pattern points to a broad, cross-system signaling/regulatory theme rather than a single pathway, so the label reflects cross-system signaling with behavioral associations.","confidence":"Medium","size":15,"edges":13,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":4},{"id":"GO:0050852","count":3},{"id":"GO:0006015","count":3},{"id":"GO:0045197","count":2},{"id":"GO:0090557","count":2}]},{"hash":"1572786288418278158","title":"Retinoid and lipid metabolism with hormonal signaling","description":"The cluster centers on retinal/retinol metabolism and broader lipid pathways (cholesterol, sorbitol biosynthesis) combined with hormone-related processes (testosterone biosynthesis regulation, prostaglandin signaling). It also includes stress- and oxidative-responses (H2O2) and even plant-like jasmonic acid signaling, suggesting a broader metabolic/hormonal signaling theme with stress responsiveness. Given the mixed terms, the label is representative but not perfectly uniform across all terms, so a Medium confidence.","confidence":"Medium","size":15,"edges":105,"triangles":455,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":9},{"id":"GO:0042572","count":9},{"id":"GO:0009414","count":8},{"id":"GO:0060135","count":8},{"id":"GO:0006061","count":8}]},{"hash":"1805563027274897367","title":"Secretory Vesicle Exocytosis Across Tissues","description":"The cluster centers on vesicle trafficking and regulated exocytosis, indicated by synaptic vesicle budding and priming, the acrosome reaction, and neutrophil degranulation. Rho signaling\u2019s role in cytoskeletal dynamics supports vesicle movement, tying these terms together. Some terms reflect tissue contexts (heart development, hypoxia response, glycogen biosynthesis) where secretory processes operate, but the unifying theme remains secretory/exocytic activity across different cell types.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0001666","count":2},{"id":"GO:0045725","count":2},{"id":"GO:1901998","count":2},{"id":"GO:0016185","count":2}]},{"hash":"1621432882833247722","title":"Fungal growth and stress response","description":"The GO terms point to fungal biology (beta-glucan cell wall biosynthesis, karyogamy) coupled with core cellular processes (SRP-dependent protein targeting, chaperone-assisted folding, iron-sulfur cluster assembly, DNA replication) and stress regulation (response to heat and hydrogen peroxide). This suggests a cluster centered on general fungal cell growth and maintenance, including protein processing and cell wall synthesis, with an emphasis on stress responses. ","confidence":"Medium","size":15,"edges":19,"triangles":12,"max_degree":9,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006616","count":3},{"id":"GO:0070389","count":3},{"id":"GO:0070880","count":3},{"id":"GO:0016226","count":3},{"id":"GO:1903751","count":3}]},{"hash":"832500578379426578","title":"Neuronal Development and Synapse Assembly","description":"The top GO terms point to neural connectivity and guidance, notably synapse assembly and dopaminergic neuron axon guidance, suggesting a neuronal development-focused cluster. Other terms touch mitochondrial transport, but the dominant signals relate to neural processes; the lack of network edges means the label reflects GO content rather than interaction structure. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":2},{"id":"GO:0045039","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0050973","count":1}]},{"hash":"1748039991697158134","title":"Neuronal Exocytosis and Synaptic Signaling","description":"Dominant GO terms point to synaptic activity and brain development (regulated exocytosis, cellular response to calcium, negative regulation of synaptic plasticity, brain development), suggesting a neuronal signaling module; a few outliers (B cell differentiation, obsolete aging terms) exist but do not override the central neural theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045055","count":1},{"id":"GO:0001302","count":1},{"id":"GO:0031914","count":1},{"id":"GO:0046456","count":1},{"id":"GO:0001324","count":1}]},{"hash":"1957013363250490148","title":"Central carbon metabolism and fatty acid biosynthesis","description":"Proteins in this cluster are enriched for core energy and lipid metabolism: glycolytic process, TCA cycle, 2-oxoglutarate metabolism, malonyl-CoA biosynthesis, long-chain fatty acid biosynthesis, and fatty acid beta-oxidation. This pattern points to a cohesive module channeling carbon from glucose through acetyl-CoA into lipid biosynthesis, with an additional signal of antibiotic biosynthetic potential among some members, suggesting possible secondary metabolism involvement.","confidence":"High","size":15,"edges":60,"triangles":158,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0006096","count":5},{"id":"GO:0017000","count":4},{"id":"GO:0019878","count":4},{"id":"GO:2001295","count":4}]},{"hash":"1419136399777147900","title":"Unknown","description":"There are no GO terms, no edges, and no connectivity to define a shared function for these 15 proteins, so a meaningful label cannot be inferred.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1271183961349030103","title":"Renal and retinal epithelial differentiation","description":"Based on the GO terms, the proteins cluster around differentiation of kidney epithelial cell types (podocytes, nephron tubule, glomerular parietal epithelium) and photoreceptor cells in the retina, with supporting roles in tissue morphogenesis and cell adhesion. Endocytosis-related terms are present but secondary to the epithelial differentiation theme, spanning both kidney and eye tissues. This suggests a common emphasis on epithelial differentiation across distant organs, hence the label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001287","count":1},{"id":"GO:0048550","count":1},{"id":"GO:0060219","count":1},{"id":"GO:0072139","count":1},{"id":"GO:0072112","count":1}]},{"hash":"414823345165520106","title":"Mammary Epithelial Proliferation and Mitotic Regulation","description":"The cluster centers on cell cycle and mitosis-related processes (G1/S and G2/M transitions, spindle pole separation, re-entry into mitosis) together with mammary gland epithelial cell proliferation, hinting at genes coordinating proliferation in mammary tissue through mitotic control, with additional signals from transcription and growth-related pathways.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0033598","count":5},{"id":"GO:0010696","count":5},{"id":"GO:0000082","count":5},{"id":"GO:0000086","count":5}]},{"hash":"473651248040343033","title":"Potassium Transport and Membrane Potential Regulation","description":"The top terms cluster around potassium ion transport and membrane potential regulation (resting potential, membrane stabilization, intracellular potassium homeostasis), indicating a shared function in cellular excitability and ion homeostasis. Some terms like estrous cycle and immune response appear, but the strongest, recurrent theme is potassium-driven membrane potential control.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044849","count":2},{"id":"GO:0006955","count":2},{"id":"GO:0050965","count":2},{"id":"GO:0060075","count":1},{"id":"GO:0098914","count":1}]},{"hash":"1542954097856282989","title":"ER-Golgi trafficking and microtubule organization","description":"This cluster centers on intracellular transport from the ER to the Golgi and on cytoskeletal dynamics, including microtubule organization and centrosome anchoring, as well as tubulin folding and membrane biogenesis. A few terms point to development (eye morphogenesis, neuron axonogenesis), suggesting a broader role in developmental cytoskeletal and trafficking processes. Overall, the proteins appear to function together in vesicle transport along microtubules and structural cytoskeletal regulation rather than a single enzymatic pathway.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0007023","count":1},{"id":"GO:0072321","count":1},{"id":"GO:1901026","count":1},{"id":"GO:0031122","count":1}]},{"hash":"1574010566953909897","title":"Unknown","description":"The GO terms are highly diverse and there are no protein-protein edges to link them into a common function, spanning development, cell cycle, signaling, ubiquitination, and mRNA transport. Since there is no cohesive theme or interaction pattern, a precise, representative label cannot be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045670","count":1},{"id":"GO:0001516","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0000747","count":1}]},{"hash":"1606340772496565677","title":"Far-Red Light Signaling and Circadian Transcription Regulation","description":"The terms show a coherent theme: far-red light signaling and phototransduction co-occurring with regulation of DNA-templated transcription and circadian rhythm. Together they point to a module where far-red light influences transcriptional programs that govern circadian timing, justifying the label \"Far-Red Light Signaling and Circadian Transcription Regulation\".","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042753","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0009585","count":1}]},{"hash":"806762197626618140","title":"Axon Guidance and Neuronal Development","description":"The top GO terms are dominated by neural-related processes such as semaphorin-plexin signaling involved in axon guidance and protein localization to juxtaparanodal regions of axons, which strongly points to neuronal development and axon organization. Some other terms relate to general development or endocrine/immune contexts, suggesting peripheral or multifunctional roles for these proteins, but the core signal most consistently points to neural development and axon guidance. Confidence: Medium","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010269","count":1},{"id":"GO:0060612","count":1},{"id":"GO:0035934","count":1},{"id":"GO:0035264","count":1},{"id":"GO:1902287","count":1}]},{"hash":"783144321878191575","title":"Telomere maintenance and DNA replication","description":"This cluster centers on genome integrity maintenance during replication, with GO terms pointing to telomere maintenance and telomerase regulation, replication fork dynamics (reversal and progression), DNA recombination, and mitochondrial DNA repair. The mix suggests a cohesive theme of maintaining both nuclear telomeres and mitochondrial genome integrity during replication.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051974","count":1},{"id":"GO:0000002","count":1},{"id":"GO:0032211","count":1},{"id":"GO:0000723","count":1},{"id":"GO:0044806","count":1}]},{"hash":"193204178591963077","title":"Dopamine/Octopamine GPCR Signaling","description":"This cluster is dominated by GO terms tied to dopaminergic signaling (dopamine uptake, dopamine receptor signaling, cAMP/PKA regulation) and octopamine/tyramine pathways, plus GPCR desensitization. The common thread is GPCR-mediated neurotransmitter signaling and downstream cAMP pathways, which captures the core function of the proteins; items like immune cell chemotaxis or urine volume regulation may reflect broader regulatory roles but are less central to the main theme.","confidence":"High","size":14,"edges":31,"triangles":19,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051586","count":10},{"id":"GO:0002407","count":10},{"id":"GO:0002882","count":10},{"id":"GO:0031649","count":10},{"id":"GO:0002032","count":10}]},{"hash":"1567990096964278375","title":"Potassium Transport and Membrane Excitability","description":"These terms cluster around regulation and maintenance of membrane potential, particularly resting potential and cardiac repolarization, along with potassium ion transmembrane transport and intracellular potassium homeostasis. This points to a shared role in cellular excitability and ionic balance, relevant to neurons and heart tissue. Other terms such as dopamine uptake regulation, dendritic cell chemotaxis, inflammation, and heat generation may reflect ancillary signaling or broader cellular context, but the core cluster appears driven by potassium-mediated control of membrane potential.","confidence":"High","size":14,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060075","count":2},{"id":"GO:0098914","count":2},{"id":"GO:0050976","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0030007","count":2}]},{"hash":"185353736386889302","title":"Embryonic neural and organ development","description":"This cluster's GO terms center on developmental processes across tissues, with strong signals for neural development (cerebellar cortex formation, Bergmann glial differentiation) and broader embryogenesis (placenta and thymus development). Insulin receptor signaling and regulation of cell proliferation suggest growth control during development, while a couple of stress-related terms may be incidental.","confidence":"Medium","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0001890","count":10},{"id":"GO:0048538","count":10},{"id":"GO:0071276","count":10},{"id":"GO:0000187","count":10},{"id":"GO:0021697","count":10}]},{"hash":"1076923655466705581","title":"Developmental Collagen/ECM Remodeling","description":"I named it Developmental Collagen/ECM Remodeling because the top terms cluster around collagen fibril organization, collagen-activated receptor signaling, skin development, and endochondral ossification, pointing to extracellular matrix\u2013driven developmental processes. Some terms (complement pathways, sodium channel clustering) are less central and likely represent ancillary associations.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043588","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3},{"id":"GO:0038063","count":3}]},{"hash":"882992604277999185","title":"Collagen-ECM Signaling in Development","description":"This cluster shows strong representation of collagen-related processes (collagen fibril organization; collagen-activated tyrosine kinase receptor signaling) along with developmental morphogenesis terms (post-embryonic body morphogenesis, endochondral ossification). The combination suggests a common theme of extracellular matrix remodeling and collagen-mediated signaling that guides development, with some immune-related terms (complement activation) indicating possible ECM-immune interactions.","confidence":"Medium","size":14,"edges":57,"triangles":101,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0040032","count":8},{"id":"GO:0042338","count":8},{"id":"GO:0001958","count":7},{"id":"GO:0033034","count":7},{"id":"GO:2000534","count":7}]},{"hash":"961954619951890440","title":"Membrane Transporters for Sugars, Ions, and Xenobiotics","description":"The top GO terms show transmembrane transport across membranes for multiple substrates, including sugars (fucose, galactose, arabinose, sialic acid), various ions (sodium, potassium, nitrate as substrate), and xenobiotics, indicating a cluster enriched for transporter proteins rather than metabolic enzymes. This pattern supports a cohesive role in membrane transport of diverse substrates.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006004","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0015757","count":11},{"id":"GO:0042128","count":11},{"id":"GO:0015751","count":11}]},{"hash":"1670978026699524991","title":"Mitotic spindle and chromosome dynamics","description":"This cluster is dominated by GO terms tied to mitosis and chromatin, notably spindle assembly and the centrosome cycle, plus chromosome/chromatin-related processes such as sperm DNA condensation and histone modification. While some terms are obsolete or less directly connected (neuron differentiation, vulval development), the strongest recurring theme points to cell division and chromatin regulation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":1},{"id":"GO:0072553","count":1},{"id":"GO:0060850","count":1},{"id":"GO:0007098","count":1},{"id":"GO:0071923","count":1}]},{"hash":"910600333517914141","title":"Interferon-Driven Antiviral Response and Vesicle Trafficking","description":"The cluster centers on innate antiviral signaling and RNA-sensing pathways, including cellular responses to type I interferon and exogenous dsRNA, along with T cell receptor signaling. In addition, several terms point to intracellular transport and Golgi-associated vesicle fusion, suggesting a link between antiviral signaling and membrane trafficking processes. A few terms (e.g., cell division, GPCR regulation) are broader but do not override the dominant immune- and trafficking-related signals.","confidence":"High","size":14,"edges":14,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0006886","count":1},{"id":"GO:0008277","count":1}]},{"hash":"1887795622806464605","title":"Broad Substrate Transmembrane Transporters","description":"This cluster\u2019s top GO terms point to diverse transmembrane transport activities, including xenobiotic and vitamin transport, nitrate/nitrite uptake, sugar (arabinose) transport, and ion transport (sodium, potassium, sialic acid). Together they suggest a cohesive function as broad-spectrum membrane transport proteins.","confidence":"High","size":14,"edges":13,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":9},{"id":"GO:0035461","count":9},{"id":"GO:0042128","count":8},{"id":"GO:1900754","count":8},{"id":"GO:0015706","count":8}]},{"hash":"1764252109699267072","title":"Spliceosome-regulated RNA processing and silencing","description":"The cluster is dominated by GO terms tied to splicing and RNA processing (regulation of mRNA splicing via spliceosome, cis splicing via spliceosome, regulation of alternative splicing, small-subunit processome assembly) along with RNA stability and RNA-mediated silencing (ncRNA/miRNA pathways, mRNA stabilization). This points to a cohesive theme of post-transcriptional regulation of RNA through splicing and silencing mechanisms.","confidence":"High","size":14,"edges":77,"triangles":275,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":8},{"id":"GO:0048026","count":8},{"id":"GO:0010610","count":6},{"id":"GO:0045292","count":6},{"id":"GO:0034462","count":5}]},{"hash":"1721211120973219506","title":"Neuronal mitochondrial dynamics and neurite morphogenesis","description":"This cluster centers on mitochondrial distribution and fission regulation in neurons, coupled with neurite development processes like dendrite morphogenesis, axon extension, and microtubule organization. The GO terms together suggest a theme of mitochondrial-cytoskeletal coordination shaping neuronal structure and connectivity.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048312","count":1},{"id":"GO:0032930","count":1},{"id":"GO:1905689","count":1},{"id":"GO:1902988","count":1},{"id":"GO:0090258","count":1}]},{"hash":"817556751375695157","title":"Developmental Signaling Pathways","description":"The cluster includes GO terms for several major signaling pathways (T cell receptor signaling, Smoothened/Hedgehog, canonical Wnt, Roundabout, and ephrin signaling) plus nervous system and kidney development, as well as processes related to cytoskeletal organization and cell cycle. This combination points to a cohesive theme of signaling pathways coordinating development and tissue patterning across multiple organ systems, rather than a single specific pathway or tissue. ","confidence":"High","size":14,"edges":7,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050852","count":7},{"id":"GO:0007224","count":6},{"id":"GO:0007399","count":6},{"id":"GO:0051496","count":6},{"id":"GO:0001822","count":6}]},{"hash":"1434044293054020827","title":"Lectin-mediated innate immunity and phagocytosis","description":"The terms cluster around innate immune recognition and response, including basophil activation, lectin pathway complement activation, C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis, pointing to fungal component recognition and inflammatory signaling (arachidonate) with some noise from kidney development terms.","confidence":"High","size":14,"edges":28,"triangles":35,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0071226","count":9},{"id":"GO:0038094","count":9},{"id":"GO:0090403","count":9}]},{"hash":"1595542256336956071","title":"Neuronal development and synaptic regulation","description":"The top GO terms point to neuronal signaling and connectivity, including ionotropic glutamate receptor signaling, nervous system development, regulation of synapse structure/activity, and axon guidance-related processes, with additional notes on neural plasticity (collateral sprouting) and related morphogenetic contexts. This cluster therefore seems to center on glutamatergic signaling and neural connectivity formation, with synaptic regulation as a core theme.","confidence":"High","size":14,"edges":6,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":1},{"id":"GO:0051563","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0060672","count":1}]},{"hash":"850390789903197320","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0048701","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0060258","count":3},{"id":"GO:0010825","count":3},{"id":"GO:0070935","count":3}]},{"hash":"1899913944450341520","title":"Developmental cytoskeleton remodeling and vesicle trafficking","description":"This cluster shows strong representation of actin cytoskeleton organization and actin crosslink formation, plus COPII-coated vesicle cargo loading, indicating cytoskeletal remodeling with vesicle trafficking. The presence of heart development, pattern specification, and fusion cell fate specification terms suggests involvement in developmental patterning processes that rely on these cellular mechanisms. Therefore, a label centered on developmental cytoskeleton dynamics and vesicle transport fits well.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0032911","count":2},{"id":"GO:2000821","count":2},{"id":"GO:1903676","count":2}]},{"hash":"808588703798497098","title":"Mitochondrial translation and mtDNA metabolism","description":"The cluster shows strong signals for translation and tRNA aminoacylation (including histidyl- and threonyl-tRNA charging) together with mitochondrial-specific processes like the respiratory electron transport chain and mitochondrial DNA metabolic processes. Although a few terms are obsolete or less directly connected (e.g., embryonic development), the dominant pattern points to mitochondrial protein synthesis machinery and mtDNA metabolism. ","confidence":"Medium","size":14,"edges":17,"triangles":5,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006450","count":3},{"id":"GO:0097056","count":2},{"id":"GO:0022904","count":2},{"id":"GO:0032042","count":2}]},{"hash":"1710824122337994808","title":"RNA splicing and post-transcriptional regulation","description":"The top terms cluster around spliceosome activity and regulation of mRNA splicing, along with factors affecting mRNA stability, silencing by ncRNA/miRNA, and translation-related processes tied to RNA maturation (e.g., processome assembly and IRES-driven initiation). This points to a cohesive role in RNA processing and post-transcriptional control, spanning splicing, stability, and silencing mechanisms.","confidence":"High","size":14,"edges":78,"triangles":286,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0048026","count":12},{"id":"GO:0031047","count":11},{"id":"GO:0010610","count":11},{"id":"GO:0034462","count":10},{"id":"GO:0075522","count":10}]},{"hash":"1614250467870882750","title":"Neuronal signaling and behavior regulation","description":"The terms cluster around neural signaling mechanisms (excitatory and GABAergic pathways, receptor clustering) and ion channel transport, coupled with behavioral readouts (locomotion, conditioned taste aversion, circadian sleep regulation). A few acrosome-related terms are present but do not define the core theme, which remains neuronal excitability and behavior.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":11},{"id":"GO:0035725","count":11},{"id":"GO:0007626","count":11},{"id":"GO:0007214","count":11},{"id":"GO:0071805","count":11}]},{"hash":"1499116345762139598","title":"Translation and tRNA charging machinery","description":"GO terms are dominated by translation-related processes, including translation itself and several aminoacyl-tRNA charging steps (leucyl-, methionyl-, valyl-, isoleucyl-tRNA aminoacylation) and regulation of translational fidelity. This suggests the cluster mainly comprises components of the protein synthesis apparatus; a few neuronal development terms appear but are much less represented and likely incidental.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030579","count":3},{"id":"GO:0006429","count":3},{"id":"GO:0006412","count":3},{"id":"GO:0006450","count":3},{"id":"GO:0006431","count":3}]},{"hash":"1289660936399755105","title":"Embryonic Organ Morphogenesis","description":"The terms point to development and morphogenesis across diverse tissues (eye, heart, hindlimb, placenta, habenula, prostate, male gonad) and include processes like myoblast proliferation and outflow tract morphogenesis. Together they indicate a common theme of embryonic organ formation and tissue patterning, with circadian regulation of gene expression potentially reflecting timing of developmental programs.","confidence":"High","size":14,"edges":83,"triangles":279,"max_degree":13,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":6},{"id":"GO:0007507","count":6},{"id":"GO:2000288","count":6},{"id":"GO:0060527","count":6},{"id":"GO:0021986","count":6}]},{"hash":"975332327339711755","title":"Unknown","description":"The top GO terms are diverse, spanning Schwann cell development, epithelial\u2013mesenchymal transition, protein localization to the kinetochore, ER-to-Golgi transport, xenobiotic response, meiotic recombination, transcription termination, and glycogen biosynthesis regulation. This breadth suggests no single coherent function or pathway unites all 14 proteins, so a specific, representative label is not discernible.","confidence":"","size":14,"edges":91,"triangles":364,"max_degree":13,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032516","count":14},{"id":"GO:0014044","count":14},{"id":"GO:0034501","count":14},{"id":"GO:0001837","count":14},{"id":"GO:0035690","count":14}]},{"hash":"471769743819821439","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":51,"triangles":117,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009561","count":1},{"id":"GO:0070934","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0008285","count":1}]},{"hash":"704409419275594589","title":"Ribosome biogenesis and transcription initiation","description":"These terms converge on ribosome biogenesis (large subunit assembly, LSU rRNA maturation, 5.8S rRNA maturation, export from the nucleus) and transcription initiation (DNA-templated transcription initiation, RNA polymerase II preinitiation complex assembly). The co-occurrence suggests a nucleolar program coordinating ribosome production with transcription machinery. A couple of terms about corpus callosum development and stem cell proliferation are more peripheral, but do not override the dominant ribosome/transcription theme.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006352","count":1},{"id":"GO:2000648","count":1},{"id":"GO:0051123","count":1},{"id":"GO:1902626","count":1},{"id":"GO:0000055","count":1}]},{"hash":"683792160379326526","title":"Embryonic organogenesis and tissue patterning","description":"The top GO terms cluster around embryonic development and organ morphogenesis across multiple tissues (somitogenesis, heart outflow tract/AV canal development, limb bud formation, pituitary development), with supporting terms for transcription and RNA processing. This suggests a broad developmental program governing tissue formation rather than a single pathway, justifying a label focused on embryonic organogenesis and patterning. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001756","count":2},{"id":"GO:0060045","count":2},{"id":"GO:0003151","count":2},{"id":"GO:0036302","count":2},{"id":"GO:0021983","count":2}]},{"hash":"825793622402335937","title":"Neural development and myelination","description":"This cluster is dominated by GO terms related to neural development, including corpus callosum development, axonal fasciculation, synapse assembly, and myelination, suggesting roles in neural connectivity and maturation. Otolith morphogenesis expands this to sensory-system development, while immune-related terms (inflammatory signaling, NOD-like pathways) appear peripheral. Overall, the core theme is neural development and myelination rather than immune function.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014068","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0032474","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0042552","count":2}]},{"hash":"1404830722778148581","title":"Unknown","description":"The top terms are very diverse, including DNA transposition, phospholipid and glycolipid biosynthesis, kynurenic acid biosynthesis, salicylic acid\u2013mediated defense signaling, and Notch signaling, with several obsolete GO terms and no observed edges or coherent functional theme tying them together.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0009405","count":1},{"id":"GO:0008654","count":1},{"id":"GO:0009247","count":1}]},{"hash":"1804544526640167150","title":"Unknown","description":"Top terms span transcription regulation (positive/negative RNA polymerase II), immune-related complement activation, and a variety of extracellular/metabolic processes with no single dominant theme. The heterogeneity suggests no cohesive function for this cluster, so Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0017000","count":4},{"id":"GO:0006958","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030574","count":3}]},{"hash":"157259469468665391","title":"Diverse Transmembrane Transporters","description":"GO terms center on transmembrane transport of xenobiotics, vitamins, sugars, ions, and related substrates, indicating a cluster of membrane transporter proteins with broad specificity.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":11},{"id":"GO:0035461","count":11},{"id":"GO:0006004","count":7},{"id":"GO:0035725","count":7},{"id":"GO:0015757","count":7}]},{"hash":"1698359653273086282","title":"Unknown","description":"The GO terms cover a mix of development (Schwann cell development), cell plasticity (epithelial to mesenchymal transition), chromosome/kinetochore dynamics, intracellular trafficking (ER to Golgi transport), stress/ xenobiotic responses, meiotic recombination, metabolism, and transcription termination\u2014there isn't a single coherent function tying these proteins together.","confidence":"","size":14,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032516","count":4},{"id":"GO:0014044","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0001837","count":4},{"id":"GO:0035690","count":4}]},{"hash":"399747977253957259","title":"Cross-Tissue Development and Morphogenesis","description":"The top GO terms cluster around developmental processes and growth across multiple tissues\u2014gonads (male/female), embryonic eye morphogenesis, mammary gland development, growth plate cartilage, and general multicellular growth\u2014with a subset touching immune signal regulation (TNF and type II interferon) and stress adaptation. This pattern suggests a shared role in tissue development and morphogenesis, hence the label. ","confidence":"Medium","size":14,"edges":12,"triangles":6,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035264","count":8},{"id":"GO:1904468","count":8},{"id":"GO:0008584","count":7},{"id":"GO:0048048","count":7},{"id":"GO:0050680","count":7}]},{"hash":"1723070145362975675","title":"Unknown","description":"The GO terms cover a wide range of processes across different tissues (signaling regulation, membrane trafficking, organ development, cell-matrix interactions, and extracellular matrix synthesis) with no single dominant theme. Because there\u2019s no cohesive function or tissue focus tying these terms together, a specific label for this cluster isn\u2019t supported beyond calling it Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071901","count":3},{"id":"GO:2001137","count":3},{"id":"GO:0060749","count":2},{"id":"GO:0021517","count":2},{"id":"GO:1904395","count":2}]},{"hash":"1587221829906067083","title":"Transcription Regulation and Complement/Coagulation Signaling","description":"The cluster shows strong signals for transcription regulation by RNA polymerase II (both negative and positive regulation), suggesting a core role in gene expression control. In addition, there are several immune/coagulation-related terms (complement activation pathways, Factor XII activation, and fibrinolysis), indicating a link between transcriptional regulation and vascular/immune signaling. The mix of transcriptional and immune/coagulation terms points to a small, specific theme but is not tightly cohesive, hence a moderate level of confidence. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0045944","count":6},{"id":"GO:0071333","count":5},{"id":"GO:0003050","count":5},{"id":"GO:0031214","count":5}]},{"hash":"45377272402099627","title":"Transmembrane ion and sugar transport","description":"The cluster\u2019s GO terms all point to transport across membranes, including proton and sodium ion transmembrane transport, vacuolar acidification, and transport of sugars (galactose, trehalose) and xenobiotics. This suggests a coherent theme of membrane transport across various substrates and compartments, with potential links to vacuolar function and osmotic/ionic balance. Confidence: Medium","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0042908","count":1},{"id":"GO:0006817","count":1},{"id":"GO:0015771","count":1}]},{"hash":"504923629333477006","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":1},{"id":"GO:0001308","count":1},{"id":"GO:0000472","count":1},{"id":"GO:1902416","count":1},{"id":"GO:0000288","count":1}]},{"hash":"1193219788310488631","title":"Developmental Morphogenesis and Differentiation","description":"This cluster\u2019s GO terms center on tissue formation and cell differentiation, including face morphogenesis, endochondral ossification, epithelial differentiation, and actomyosin cytoskeleton organization, with a note of insect developmental signaling (juvenile hormone) and sensory-related processes (olfactory behavior, chemical detection). The common thread is morphogenesis and differentiation guiding tissue and organ development, with ancillary immune and sensory aspects reflected in the terms. ","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":3},{"id":"GO:0035626","count":1},{"id":"GO:0031032","count":1},{"id":"GO:1904706","count":1},{"id":"GO:0030855","count":1}]},{"hash":"1762400679137953621","title":"Unknown","description":"The top terms cover amino acid metabolism (threonine biosynthesis, methionine salvage), transcription-related processes (RNA Pol II transcription, RNA-templated DNA synthesis), and protein regulation, with no single clear function tying all terms together and no network connections, so a coherent thematic label is not supported.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009088","count":2},{"id":"GO:0019509","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0016310","count":2},{"id":"GO:0046677","count":2}]},{"hash":"343427112599182175","title":"Cytoskeleton organization and cell signaling","description":"GO terms indicate cytoskeletal dynamics (microtubule cytoskeleton polarity, neurofilament bundle assembly, keratinocyte activation) and nuclear transport/signaling (nuclear pore localization, I-kappaB phosphorylation). Some terms reflect broader stress/immune responses (hepatocyte apoptotic process, complement activation), but the core theme appears to be cytoskeletal remodeling linked with signaling under stress.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097284","count":2},{"id":"GO:1901998","count":2},{"id":"GO:0007252","count":2},{"id":"GO:0031081","count":1},{"id":"GO:0032980","count":1}]},{"hash":"345794926919896616","title":"ECM Adhesion and Collagen Signaling in Development","description":"The cluster is dominated by terms related to extracellular matrix interactions and collagen dynamics (cell adhesion; collagen fibril organization; collagen-activated tyrosine kinase receptor signaling) and developmental processes (endochondral ossification), suggesting roles in ECM adhesion and skeletal development. Additional associations with kidney-related processes (renal albumin absorption; metanephric mesenchymal cell migration) and immune activation (complement pathways) imply broader ECM-immune roles across organ development. Overall, the theme is extracellular matrix adhesion and collagen signaling in development.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0001958","count":2},{"id":"GO:0033034","count":2},{"id":"GO:2000534","count":2},{"id":"GO:0038063","count":2}]},{"hash":"144220269781034061","title":"Ammonium Transport and Nitrogen Metabolism","description":"The GO terms cluster around ammonium and nitrogen transport and utilization (ammonium transmembrane transport, transepithelial ammonium transport, regulation of nitrogen utilization) with related terms like carbon dioxide transport and proteolysis; some entries also reflect nutrient-stress growth responses (pseudohyphal and invasive growth). This points to a theme of nitrogen handling and related transport processes, though a few terms are more distant, so the label is plausible but not definitive.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0015843","count":1},{"id":"GO:0080181","count":1},{"id":"GO:0015670","count":1},{"id":"GO:0070634","count":1}]},{"hash":"1910761840453204702","title":"NOD signaling and inflammatory response to bacterial ligands","description":"This cluster is characterized by GO terms for detection of lipopolysaccharide and positive regulation of NOD1/NOD2 signaling, leading to inflammatory activities such as chemokine production and IL-18 synthesis, indicating a theme of bacterial ligand sensing and innate immune response. One term about corpus callosum development appears unrelated, but the dominant pattern points to bacterial recognition and inflammation.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":1},{"id":"GO:0070434","count":1},{"id":"GO:0071727","count":1},{"id":"GO:0050729","count":1},{"id":"GO:0035751","count":1}]},{"hash":"128856108375368255","title":"Collagen-ECM Signaling in Connective Tissue Development","description":"This cluster\u2019s top GO terms cluster around collagen fibril organization and a collagen-activated receptor signaling pathway, which aligns with extracellular matrix (ECM)\u2013mediated processes and connective tissue development (including endochondral ossification). While there are additional terms related to eye morphogenesis and some immune-related processes (complement activation), the strongest common theme across terms is ECM organization and collagen-driven signaling guiding developmental processes in connective tissues.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":2},{"id":"GO:0033034","count":2},{"id":"GO:2000534","count":2},{"id":"GO:0038063","count":2},{"id":"GO:0001867","count":2}]},{"hash":"771769365972424470","title":"Collagen-driven morphogenesis and ECM signaling","description":"GO terms center on collagen/fibril organization, collagen-activated signaling, and developmental morphogenesis (post-embryonic), with related cuticle development and ossification terms, indicating extracellular matrix remodeling as the core theme. Some immune (complement) and kidney-related terms appear but are likely secondary context to ECM-driven developmental processes. Medium","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0040032","count":4},{"id":"GO:0042338","count":4},{"id":"GO:0001958","count":3},{"id":"GO:0033034","count":3},{"id":"GO:2000534","count":3}]},{"hash":"1047968005464829166","title":"Potassium Ion Transport and Membrane Potential Regulation","description":"The top GO terms are centered on potassium ion transport and the stabilization and regulation of membrane potential, including cardiac atrial repolarization and intracellular potassium homeostasis. This suggests the proteins function together to maintain ion balance and membrane excitability, despite a few outlier terms related to development or DNA damage that may be incidental. ","confidence":"High","size":13,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060075","count":1},{"id":"GO:0098914","count":1},{"id":"GO:0050976","count":1},{"id":"GO:0071805","count":1},{"id":"GO:0030007","count":1}]},{"hash":"636459865786748440","title":"Neural crest migration and axon guidance","description":"The cluster is dominated by terms related to neural development and guidance, including semaphorin-plexin signaling in axon guidance, sympathetic neuron projection guidance, and neural crest cell migration in the autonomic nervous system. Other terms (endothelial chemotaxis, sphingolipid metabolism, prostate development) are peripheral, but the core theme is signaling that directs neural cell movement and pathfinding.","confidence":"High","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060742","count":1},{"id":"GO:1903206","count":1},{"id":"GO:0006665","count":1},{"id":"GO:0060736","count":1},{"id":"GO:0007193","count":1}]},{"hash":"1073799848163191650","title":"Junction Assembly and Receptor Signaling","description":"This cluster blends junction-related processes (smooth septate and paranodal junction assembly) with receptor-mediated signaling (receptor attachment and internalization, cell surface receptor signaling). Additional terms point to downstream pathways like NF-kappaB, VEGF, and integrin signaling, suggesting proteins that couple cell\u2013cell contacts to signaling cascades; the photoreceptor differentiation term may reflect tissue-specific roles but doesn\u2019t override the junction-signaling core.","confidence":"Medium","size":13,"edges":19,"triangles":6,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0090528","count":3},{"id":"GO:0046813","count":3},{"id":"GO:0031623","count":3},{"id":"GO:1901223","count":3},{"id":"GO:0007166","count":3}]},{"hash":"2114870850080319885","title":"Viral budding and endosomal trafficking","description":"The prominent terms point to virus life cycle steps\u2014release and envelopment\u2014coupled with host vesicle transport (endosome to vacuole, general protein transport). This suggests a cluster of proteins involved in viral budding/egress that hijack endosomal trafficking pathways. Some terms like abscission and collateral sprouting are less central, but the core theme is viral egress via cellular trafficking.","confidence":"Medium","size":13,"edges":19,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0019076","count":1},{"id":"GO:0048672","count":1},{"id":"GO:0046745","count":1},{"id":"GO:0009838","count":1},{"id":"GO:0032511","count":1}]},{"hash":"1290349534764041993","title":"Transcription and Cytoskeletal Signaling Regulators","description":"The cluster includes GO terms pointing to transcriptional regulation (DNA-templated transcription), cytoskeletal control (barbed-end actin filament capping) and signaling (positive regulation of GTPase activity, peptidyl-tyrosine phosphorylation, TGF-beta response), along with ubiquitination and cell-cycle involvement. This combination suggests a regulatory module coordinating gene expression with signaling and cytoskeletal dynamics during growth and division.","confidence":"Medium","size":13,"edges":19,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000747","count":2},{"id":"GO:0051016","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0050731","count":2}]},{"hash":"933364343929034831","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":9,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006637","count":3},{"id":"GO:0071353","count":2},{"id":"GO:0008616","count":2},{"id":"GO:0101030","count":2},{"id":"GO:0043419","count":1}]},{"hash":"571103810367113305","title":"Plant secondary metabolite biosynthesis","description":"This cluster is dominated by GO terms for biosynthesis of plant secondary metabolites, including anthocyanin-containing compounds, kaempferol glucoside, and lignin, suggesting a common theme of polyphenol and related metabolite production. Additional terms point to glycosylation-related biosynthesis (dolichol-linked oligosaccharide) and broader metabolic processes, while a few entries (e.g., cell cycle or axon localization) appear less connected and may reflect annotation noise. Overall, the core signal is biosynthetic processes involved in plant secondary metabolite production.","confidence":"Medium","size":13,"edges":14,"triangles":4,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":8},{"id":"GO:0051301","count":6},{"id":"GO:0052697","count":6},{"id":"GO:0007049","count":6},{"id":"GO:0016999","count":6}]},{"hash":"979218017880440995","title":"RNA Processing and Ribosome Biogenesis","description":"The most represented terms center on RNA metabolism and protein synthesis\u2014translation, rRNA maturation, mRNA export, and spliceosomal/disassembly and transcription termination\u2014indicating a cluster of RNA processing and ribosome-biogenesis factors that drive gene expression. Some terms are more peripheral (DNA damage tolerance, ncRNA-mediated silencing), but the core signal points to RNA maturation and translation machinery.","confidence":"High","size":13,"edges":38,"triangles":62,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":7},{"id":"GO:0000462","count":3},{"id":"GO:0006301","count":2},{"id":"GO:0006369","count":2},{"id":"GO:0000390","count":2}]},{"hash":"1842830322789359760","title":"Mitochondrial Translation and ETC Assembly","description":"Protein set is enriched for GO terms tied to mitochondrial protein synthesis (translation, regulation of translational fidelity) and assembly of respiratory chain complexes III and IV, pointing to a coordinated role in mitochondrial gene expression and ETC biogenesis. The other terms (photosynthesis, cobalamin metabolism, general transport) are less central or reflect broader annotations, but do not override the dominant theme of mitochondrial translation and ETC assembly.","confidence":"High","size":13,"edges":69,"triangles":204,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070131","count":2},{"id":"GO:0034551","count":1},{"id":"GO:0009235","count":1},{"id":"GO:0045903","count":1},{"id":"GO:0019684","count":1}]},{"hash":"302245888533032887","title":"Phospholipid metabolism regulation","description":"The cluster is dominated by GO terms tied to phospholipid pathways (regulation of phosphatidylinositol dephosphorylation; positive regulation of phosphatidylcholine biosynthesis; negative regulation of phosphatidylglycerol biosynthesis), suggesting a shared theme of membrane lipid metabolism and remodeling. Some listed terms are peripheral, but the strongest signal points to phospholipid biosynthesis/dephosphorylation processes that affect membrane composition and dynamics.","confidence":"Medium","size":13,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060304","count":1},{"id":"GO:0007584","count":1},{"id":"GO:0044791","count":1},{"id":"GO:0001892","count":1},{"id":"GO:0043942","count":1}]},{"hash":"1864541576750480344","title":"ER-Golgi trafficking and secretion","description":"The top GO terms show strong enrichment for ER-to-Golgi transport, ER lumen retention, COPI vesicle budding, and Golgi ribbon formation, with related terms for protein exit and secretion (including Wnt secretion and amyloid-beta regulation). This points to a cohesive function in the early secretory pathway and protein trafficking. Some peripheral terms likely reflect broader or misannotated associations but do not override the main theme.","confidence":"High","size":13,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0090161","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0070863","count":1}]},{"hash":"1911568462600535108","title":"Unknown","description":"The top GO terms span very different processes (Schwann cell development, epithelial to mesenchymal transition, kinetochore localization, meiotic recombination, ER-Golgi transport, glycogen biosynthesis, transcription termination, xenobiotic response). There isn\u2019t a single cohesive function or pathway linking these terms, indicating a heterogeneous cluster rather than a specific theme.","confidence":"","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0032516","count":13},{"id":"GO:0014044","count":13},{"id":"GO:0034501","count":13},{"id":"GO:0001837","count":13},{"id":"GO:0035690","count":13}]},{"hash":"2118671192581065935","title":"Muscle and Heart Development with Transcription Regulation","description":"This cluster includes GO terms focused on muscle and cardiac development (skeletal muscle cell differentiation, heart development) and transcriptional control (DNA-templated transcription, negative regulation of transcription by RNA Pol II), suggesting a core theme of muscle/heart development governed by transcriptional regulation. Additional terms point to glucocorticoid responsiveness (cellular response to dexamethasone) and ubiquitin-related protein turnover (ubiquitin-dependent catabolic process, deubiquitination), which can co-occur in hormone-responsive muscle tissue remodeling. An outlier term on SSU-rRNA maturation exists but does not override the dominant developmental/transcriptional theme. Confidence is Moderate.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0035914","count":1},{"id":"GO:0018027","count":1},{"id":"GO:1902035","count":1}]},{"hash":"814896894796129822","title":"Golgi-Endosome Trafficking and Cell Cycle Regulation","description":"This cluster centers on proteins involved in Golgi localization and retrograde transport from endosomes to the Golgi, suggesting a trafficking-focused function. The presence of cell cycle and division-related terms also points to coordinated roles in cellular proliferation, though several terms are unrelated or obsolete, making the association moderately confident.","confidence":"Medium","size":13,"edges":27,"triangles":8,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000747","count":2},{"id":"GO:1902902","count":2},{"id":"GO:0007049","count":2},{"id":"GO:0035751","count":2}]},{"hash":"811381942623196146","title":"Unknown","description":"The top GO terms span diverse functions\u2014from retina development and nuclear import to immune signaling, kinase activation, and multiple metabolic pathways (GMP, carbohydrate metabolism, homocysteine/cysteine turnover) plus transport and protein complex formation\u2014showing no single coherent theme. ","confidence":"","size":13,"edges":71,"triangles":220,"max_degree":12,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0060041","count":7},{"id":"GO:1902593","count":7},{"id":"GO:0071353","count":7},{"id":"GO:0032147","count":7},{"id":"GO:0019343","count":7}]},{"hash":"1803510509158742924","title":"Mitochondrial metabolite transport and energy regulation","description":"The proteins in this cluster primarily show transport of diverse cofactors and metabolites across mitochondrial membranes (nucleotides, ATP, thiamine pyrophosphate, coenzyme A, heme) and related energy processes such as the malate-aspartate shuttle and regulation of membrane potential. While terms like IGF signaling and pregnancy appear, the strongest, most consistent signal is mitochondrial transport/metabolic regulation, justifying a focused label on mitochondrial metabolite transport and energy balance.","confidence":"High","size":13,"edges":35,"triangles":35,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":10},{"id":"GO:0007565","count":10},{"id":"GO:0043490","count":10},{"id":"GO:1990544","count":10},{"id":"GO:0030974","count":10}]},{"hash":"1359235429047128116","title":"Embryonic morphogenesis and organ development","description":"This cluster shows morphogenesis across multiple organs (eye, heart/outflow tract, habenula, placenta, prostate) plus transcriptional regulation related to development and growth control, indicating a core role in embryonic organ development.","confidence":"High","size":13,"edges":72,"triangles":229,"max_degree":12,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":7},{"id":"GO:0007507","count":7},{"id":"GO:2000288","count":7},{"id":"GO:0060527","count":7},{"id":"GO:0021986","count":7}]},{"hash":"989702981100257088","title":"Collagen-ECM Remodeling & Complement Activation","description":"The cluster's terms repeatedly reference collagen fibril organization and collagen-activated signaling, as well as cuticle development involving collagen, which together suggest extracellular matrix (ECM) remodeling. The presence of complement activation pathways (lectin and classical) indicates immune-related functions that can interact with ECM contexts. Additional terms related to ossification and tissue development fit within connective tissue and organogenesis themes, while the ion channel clustering and kidney-related term appear less central but not contradictory. Overall, the cohesive theme centers on collagen/ECM dynamics with accompanying immune activity.","confidence":"Medium","size":13,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042338","count":3},{"id":"GO:0001958","count":2},{"id":"GO:0033034","count":2},{"id":"GO:2000534","count":2},{"id":"GO:0038063","count":2}]},{"hash":"1848052674225704686","title":"RNA decay and translation regulation","description":"This cluster centers on RNA metabolism, highlighted by terms for deadenylation-dependent and -independent mRNA decay, regulation of cytoplasmic translation, and (obsolete) polyadenylation. While there are a few outlier terms related to immune signaling and development, the strongest shared theme among the terms is RNA stability and translation control, suggesting the proteins collectively engage in RNA processing rather than a single coherent signaling pathway. The lack of edges reinforces the idea of functional diversity with a core RNA-regulatory signal.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:1900153","count":1},{"id":"GO:0031086","count":1},{"id":"GO:0061470","count":1},{"id":"GO:0060710","count":1}]},{"hash":"1061202465442940493","title":"DNA Replication and Nucleotide-Excision Repair","description":"The cluster is dominated by terms for DNA replication and nucleotide-excision repair, along with related DNA repair and unwinding processes, indicating a genome maintenance role. Nonsense-mediated decay points to RNA quality control linked to gene expression during genome maintenance. Developmental terms are present but less central, so the core theme remains genome integrity via replication and repair pathways.","confidence":"High","size":13,"edges":15,"triangles":8,"max_degree":7,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0000184","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0000717","count":4},{"id":"GO:0006310","count":4},{"id":"GO:0048568","count":4}]},{"hash":"1838056902711787484","title":"Unknown","description":"The top GO terms span plant defense (camalexin biosynthesis, salicylic acid signaling), cell-wall polysaccharide catabolism (pectin, cellulose), lipid catabolism (phosphatidylserine), vesicle trafficking (multivesicular body disassembly), and neural signaling (GPCR glutamate signaling, neuroblast proliferation). This wide diversity lacks a single coherent function or pathway that unites most proteins, so a concise, representative label cannot be assigned.","confidence":"","size":13,"edges":36,"triangles":24,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045490","count":6},{"id":"GO:0042136","count":6},{"id":"GO:2000124","count":6},{"id":"GO:0007216","count":6},{"id":"GO:0006660","count":6}]},{"hash":"2094083287569798837","title":"Retroviral DNA Integration and Latency","description":"The top GO terms point to key retroviral life-cycle steps: DNA integration into the host genome, establishment of proviral latency, and RNA-templated DNA biosynthesis (reverse transcription), along with DNA replication and recombination. Additional terms like viral penetration into the host nucleus and symbiont entry reflect entry into host cells, while negative regulation of siRNA processing indicates viral interference with host RNAi defenses and mitotic nuclear membrane disassembly suggests cell-cycle\u2013related effects during infection. Together, these terms form a coherent theme around retroviral integration, latency, and host interaction.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":3},{"id":"GO:0075713","count":2},{"id":"GO:0075732","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0039651","count":1}]},{"hash":"1483394920941245978","title":"DNA Transposition and Transcription Regulation","description":"This cluster shows enrichment for DNA mobility terms (DNA integration, DNA transposition) and transcription control (DNA-templated transcription and its regulation), pointing to functions in mobile genetic elements or genome regulation. A few metabolic and redox-related terms are present but appear secondary to the dominant DNA-centric themes.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":3},{"id":"GO:0015074","count":2},{"id":"GO:0006313","count":2},{"id":"GO:0046688","count":1},{"id":"GO:0006355","count":1}]},{"hash":"1577037257780589975","title":"Growth and development signaling hub","description":"The cluster combines core growth and developmental processes (ribosome biogenesis, DNA replication, DNA-templated transcription, centrosome cycle, multicellular and forebrain development) with metabolic and stress signaling (insulin receptor pathway, JNK cascade) and context-dependent responses (invasive growth under glucose limitation, defense response to Gram-positive bacteria). This suggests a theme of coordinating growth, development, and cellular signaling across contexts rather than a single, cohesive complex; the dispersed terms point to a general regulatory module rather than a tight pathway. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":3},{"id":"GO:0007275","count":2},{"id":"GO:0001403","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1225429280810850283","title":"Chromatin modification during development","description":"The cluster centers on histone acetylation (chromatin modification) terms paired with development and differentiation terms (multicellular development, cell differentiation, inner cell mass proliferation, fat cell differentiation), suggesting a theme where chromatin state regulates developmental cell fate. A gravitaxis term appears unrelated noise, and there are no interactions among proteins, but the core coherence remains chromatin regulation in development.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043981","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0042332","count":1},{"id":"GO:0043984","count":1},{"id":"GO:0001833","count":1}]},{"hash":"319239671056333972","title":"Cardiac muscle development and vascular regulation","description":"The terms point to heart development and muscle differentiation, including positive regulation of cardiac muscle cell differentiation and ductus arteriosus closure, with related vascular (smooth muscle) migration regulation. Apoptotic and telomere maintenance terms exist but are less central to the cluster\u2019s main theme, which centers on cardiac/vascular development and muscle differentiation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0043654","count":1},{"id":"GO:0015917","count":1},{"id":"GO:0003257","count":1},{"id":"GO:0097070","count":1}]},{"hash":"2287669243611870506","title":"Unknown","description":"The top GO terms cover aging, brain development, synaptic regulation, calcium signaling, immune modulation, and insulin secretion, which do not point to a single cohesive function for the cluster. There are no obvious shared pathways or interactions linking all terms, so a specific label cannot be confidently assigned.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001302","count":1},{"id":"GO:0031914","count":1},{"id":"GO:0046456","count":1},{"id":"GO:0001324","count":1},{"id":"GO:0071277","count":1}]},{"hash":"1829002792108308461","title":"Secretory vesicle trafficking and exocytosis","description":"This cluster is characterized by GO terms tied to vesicle formation, targeting, and fusion (vesicle fusion with Golgi, vesicle targeting, vacuole fusion), along with secretion-related processes such as histamine release, eosinophil degranulation, and mucus secretion. The combination suggests proteins involved in the secretory pathway and regulated exocytosis across immune and mucosal contexts, with additional related trafficking steps like endosome-to-Golgi transport and lipid transport contributing to membrane trafficking functions.","confidence":"High","size":12,"edges":15,"triangles":4,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:1903595","count":2},{"id":"GO:0042147","count":2},{"id":"GO:0034197","count":2},{"id":"GO:0043308","count":2},{"id":"GO:0048280","count":2}]},{"hash":"531512245985273027","title":"Oocyte mRNA translation regulation and axis patterning","description":"The cluster is driven by terms tied to oocyte development, especially oskar mRNA translation and dorsal/ventral axis specification (e.g., regulation of oskar mRNA translation, oocyte axis specification). It also includes related translation control and mRNA stability processes (IRES-dependent initiation, miRNA-mediated silencing, mRNA stabilization). While some terms touch broader RNA processing, the dominant theme is translational control of specific maternal mRNAs guiding axis formation in oocytes. ","confidence":"Medium","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007310","count":1},{"id":"GO:0034462","count":1},{"id":"GO:0060213","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1901407","count":1}]},{"hash":"553890264291488541","title":"Dopamine GPCR signaling and cAMP regulation","description":"This cluster is anchored by dopaminergic GPCR signaling terms, including adenylate cyclase\u2013activating dopamine receptor pathways and regulation of cAMP/PKA activity, suggesting a core theme around dopamine receptor\u2013mediated signaling and downstream cAMP signaling. Additional terms hint at broader signaling contexts (calcium release, octopamine/tyramine signaling) that may reflect overlapping pathways or functional connections, but the dominant signal is dopamine receptor\u2013related GPCR signaling and its regulation of cAMP pathways.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0051209","count":2},{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1}]},{"hash":"2057514367602835912","title":"Unknown","description":"The top GO terms are highly diverse, covering sensory perception of sound, development (skin, male gonad), translation initiation, transcription regulation, proteasomal protein degradation, membrane potential, pH change, spore formation, and amino acid transport. With no evident shared pathway and no edges in the network, there is no cohesive function tying these proteins together, so a specific label cannot be assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0031146","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0001731","count":3}]},{"hash":"855707010999705094","title":"Organ morphogenesis and vesicle trafficking","description":"The top GO terms point to broad organ development (brain, liver, cochlea) and apoptosis regulation, alongside vesicle trafficking processes (COPII vesicle budding) and ER-related turnover (reticulophagy). Additional terms reflect cell movement and signaling (hemocyte migration, podosome assembly, androgen receptor pathway) and cell cycle, suggesting a cluster centered on tissue morphogenesis that relies on intracellular trafficking and dynamic cell behavior. Confidence in this label is moderate because while the theme is coherent, the mix includes diverse processes beyond a single ancestral function.","confidence":"Medium","size":12,"edges":19,"triangles":9,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007420","count":10},{"id":"GO:0001889","count":10},{"id":"GO:0090103","count":10},{"id":"GO:0043524","count":10},{"id":"GO:0090114","count":10}]},{"hash":"2185998139632954605","title":"Podocyte development and mitochondrial dynamics","description":"The top terms include metanephric podocyte development and excretion (kidney function), cadherin-mediated adhesion (podocyte cell junctions), and PKC signaling, pointing to podocyte biology and renal function. Several terms also reflect mitochondrial processes (inner mitochondrial membrane organization, mtDNA replication, mitochondrial inheritance), suggesting coordinated regulation of energy and structural dynamics in these cells. Together, they indicate a theme of podocyte development linked with mitochondrial regulation.","confidence":"Medium","size":12,"edges":26,"triangles":27,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0072249","count":6},{"id":"GO:1903905","count":6},{"id":"GO:0007588","count":6},{"id":"GO:0052547","count":6},{"id":"GO:0000001","count":6}]},{"hash":"1672419982703658242","title":"Amino acid and neurotransmitter transport","description":"The cluster is dominated by GO terms for transport of amino acids and neurotransmitters across membranes (GABA, arginine, D-alanine, D-serine, ammonium) and related transepithelial transport, with an additional note on cell volume homeostasis. This points to a set of membrane transport proteins whose primary function is moving amino acids and related molecules between cellular compartments or across epithelia; some older terms are present as historical annotations but do not change the overall theme.","confidence":"High","size":12,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0015812","count":2},{"id":"GO:0006527","count":2},{"id":"GO:0097638","count":2},{"id":"GO:0035826","count":2},{"id":"GO:0098713","count":2}]},{"hash":"2181019523035837140","title":"Unknown","description":"The Top Terms show a broad mix: heart development and heart process, adrenergic signaling in the heart, vesicle trafficking, Rac signaling, grooming behavior, anterior/posterior patterning, cell fate specification, phagocytosis, and even obsolete regulatory terms. There isn't a single cohesive biological function or pathway that ties these proteins together. As such, the cluster cannot be confidently assigned a specific, interpretable function, so 'Unknown' with confidence None. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090110","count":1},{"id":"GO:0035022","count":1},{"id":"GO:1900169","count":1},{"id":"GO:2000821","count":1},{"id":"GO:0086023","count":1}]},{"hash":"1033246365932052510","title":"RNA Splicing Machinery","description":"The top terms are dominated by mRNA splicing via the spliceosome and related spliceosome-assembly/catalysis steps (GO:0000398, GO:0000350, GO:0039651, GO:0000380, GO:0045292), indicating a cohesive cluster of spliceosome components involved in RNA processing. A few other terms (DNA integration, proviral latency, actin cytoskeleton) are present but do not override the main spliceosome signal, suggesting occasional multifunctional annotations rather than a different primary function.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0000350","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0000380","count":2},{"id":"GO:0075713","count":2}]},{"hash":"773039815001099053","title":"Nematode Developmental and Reproductive Processes","description":"The top GO terms point to developmental and reproductive biology in nematodes (embryogenesis/morphogenesis, maternal axis specification, polyspermy prevention, pharyngeal function, cuticle molting) and related chromatin remodeling and proteolysis. Despite no network connections, these functions coalesce around nematode development and reproduction, suggesting a cohesive theme for this cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043044","count":2},{"id":"GO:0048632","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0006508","count":1},{"id":"GO:0007313","count":1}]},{"hash":"733265485769111073","title":"Gram-positive cell wall biosynthesis and NRPS antibiotics","description":"The top GO terms cluster around Gram-positive cell envelope biosynthesis (lipoteichoic and teichoic acids, cell wall organization, fatty acid and lipid A biosynthesis) plus nonribosomal peptide biosynthesis and antibiotic biosynthesis, suggesting a cohesive theme of cell wall\u2013related construction coupled with NRPS-derived antibiotic production.","confidence":"Medium","size":12,"edges":64,"triangles":201,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":4},{"id":"GO:0055114","count":3},{"id":"GO:0010124","count":3},{"id":"GO:0006099","count":3},{"id":"GO:0070395","count":2}]},{"hash":"1618221276474020230","title":"Central Carbon Metabolism and Cofactor Biosynthesis","description":"The proteins in this cluster are enriched for core energy metabolism and biosynthesis of cofactors, including the TCA cycle, glyoxylate and pyruvate pathways, and biosynthesis of cofactors such as biotin and quinolinate (NAD) as well as heme-related porphyrinogen production, indicating a cohesive module centered on central carbon flux and cofactor production.","confidence":"High","size":12,"edges":54,"triangles":134,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":5},{"id":"GO:0019878","count":4},{"id":"GO:0006782","count":4},{"id":"GO:0009436","count":4},{"id":"GO:0042853","count":3}]},{"hash":"1878038156101391594","title":"Sterol and lipid biosynthesis","description":"The dominant GO terms point to lipid metabolism and sterol regulation, including ergosterol biosynthesis regulation, sphingolipid metabolism, and unsaturated fatty acid biosynthesis, with supporting signals from tissue-specific lipid processes like myelin maintenance and sebaceous gland differentiation. A few terms (nitrate assimilation, nitric oxide biosynthesis, wound healing, mitochondrial inheritance) appear less connected to this core theme and may reflect broader or incidental functions within the cluster. Overall, the data suggest a cohesive theme around sterol and lipid biosynthesis with some noise from unrelated processes.","confidence":"Medium","size":12,"edges":14,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":2},{"id":"GO:0006675","count":2},{"id":"GO:0032443","count":2},{"id":"GO:0001949","count":2},{"id":"GO:0006809","count":2}]},{"hash":"1099358490526506359","title":"Mitochondrial translation and respiratory chain assembly","description":"The top GO terms cluster around mitochondrial-specific processes: translation and rRNA maturation, protein import into the mitochondrial matrix, and assembly of respiratory chain complexes I, II, and IV, with an additional plant development context. This suggests a cohesive theme of mitochondrial gene expression and assembly of the electron transport chain in plants.","confidence":"High","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000462","count":2},{"id":"GO:0031564","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0034553","count":1}]},{"hash":"991131762400837274","title":"Retinal photoreceptor development and chromatin regulation","description":"The top GO terms cluster around retina-specific development and maintenance of photoreceptors, coupled with chromatin remodeling and histone modification, suggesting a cohesive theme of epigenetic control guiding photoreceptor differentiation and survival in the neural retina. Some neural-related processes like myelin assembly appear, but the emphasis remains on photoreceptor development and gene regulation.","confidence":"Medium","size":12,"edges":4,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032288","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0042462","count":2},{"id":"GO:0045494","count":2},{"id":"GO:0016239","count":2}]},{"hash":"354723040015612684","title":"Ribosome biogenesis and translation","description":"The strongest signals are translation and ribosome biogenesis (cytoplasmic translation, ribosomal subunit export), indicating this cluster mainly represents ribosome assembly and protein-synthesis machinery; the cell-cycle/division terms likely reflect coupling of growth with ribosome production.","confidence":"High","size":12,"edges":62,"triangles":184,"max_degree":11,"top_function":"cytoplasmic translation","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0002181","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0007049","count":3}]},{"hash":"1408866146114413724","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":2},{"id":"GO:0019076","count":1},{"id":"GO:0010587","count":1},{"id":"GO:0039702","count":1},{"id":"GO:0039651","count":1}]},{"hash":"697667135794324650","title":"Unknown","description":"Unknown","confidence":"","size":12,"edges":12,"triangles":1,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006458","count":2},{"id":"GO:0097428","count":2},{"id":"GO:0036494","count":2},{"id":"GO:0071630","count":2},{"id":"GO:0006452","count":2}]},{"hash":"2161848434278623372","title":"Membrane Transporters for Nutrients and Osmolytes","description":"The cluster is rich in GO terms about transmembrane and plasma membrane transport of diverse solutes (nitrate, phosphate, sodium, galactose, trehalose, fucose, selenite) and xenobiotics, plus an osmotic-stress response, pointing to a cohesive role in nutrient uptake and osmotic adaptation via membrane transporters. Some metabolic terms appear, but the transport theme dominates, supporting this labeling.","confidence":"High","size":12,"edges":13,"triangles":2,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":3},{"id":"GO:0042908","count":2},{"id":"GO:0006817","count":2},{"id":"GO:0015771","count":2},{"id":"GO:0052106","count":2}]},{"hash":"546452240568057661","title":"Cardiac signaling and calcium handling","description":"Proteins in this cluster are enriched for heart development, regulation of cardiac muscle contraction, and release of sequestered calcium into the cytosol, pointing to cardiac signaling and excitation-contraction coupling. Additional signaling terms (protein phosphorylation, GTPase activity, and adenylate cyclase/cAMP) support modulation of cardiac function. A couple of terms (visual perception, amphetamine response) are broader or noisy annotations, but do not undermine the overall cardiac signaling theme.","confidence":"High","size":12,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0008284","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0055117","count":2},{"id":"GO:0001975","count":2},{"id":"GO:0043950","count":2}]},{"hash":"787236178312452490","title":"Mitochondrial Translation and Lipid Metabolism","description":"The top GO terms point strongly to mitochondrial protein synthesis (mitochondrial translation and tRNA biosynthesis via transamidation) and lipid-related pathways (fatty acid catabolism and oxylipin biosynthesis), with ER organization supporting organelle membranes and function. Although there are a few outlier terms (nylon catabolic process, stamen development), the dominant signal ties mitochondrial translation to lipid metabolism and related stress responses, justifying this label as representative of the cluster\u2019s core function.","confidence":"Medium","size":12,"edges":18,"triangles":7,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":7},{"id":"GO:0070681","count":7},{"id":"GO:0007029","count":7},{"id":"GO:0009062","count":7},{"id":"GO:0019876","count":7}]},{"hash":"882119208102337482","title":"Gene Expression and Protein Trafficking","description":"The top GO terms cluster around gene expression processes (mRNA splicing via spliceosome, translation initiation/reinitiation) and protein handling/trafficking (ER-to-Golgi vesicle transport, formation of translation preinitiation complex), suggesting a cohesive theme of protein synthesis and routing through the secretory pathway. Some terms (signaling, pigmentation, carbohydrate metabolism) seem peripheral to this core, but the dominant signals point to expression and processing rather than a single metabolic or signaling pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0006888","count":2}]},{"hash":"2131270397285248136","title":"Proteolysis-driven Peptide Processing and Hormonal Regulation","description":"The cluster\u2019s prominent GO terms center on proteolysis, protein catabolic processes, and digestion, pointing to proteolytic processing of peptides. Several terms involve maturation of peptide hormones (angiotensin) and renin-angiotensin\u2013mediated regulation of blood volume, suggesting a peptide-processing/endocrine theme. Additional terms about antigen processing/presentation via MHC II and systemic acquired resistance indicate peptide handling relevant to immune function. While some terms (e.g., mesonephros development) are less directly tied, the unifying thread is proteolytic processing of peptides that feed into digestion, immune peptide presentation, and hormone maturation.","confidence":"Medium","size":12,"edges":24,"triangles":11,"max_degree":9,"top_function":"protein catabolic process","top_go_terms":[{"id":"GO:0016540","count":7},{"id":"GO:0002803","count":7},{"id":"GO:0019886","count":7},{"id":"GO:0009627","count":7},{"id":"GO:0007586","count":7}]},{"hash":"1731218702521631325","title":"Epithelial junctions and cytoskeletal remodeling","description":"Based on the dominant terms, the proteins cluster around epithelial cell-cell adhesion and apical junction assembly, paired with cytoskeletal remodeling such as stress fiber and filopodium assembly, and associated membrane trafficking (endosome localization, exosomal secretion). While there are related signals like NF-kappaB regulation and axon guidance, the strongest recurring theme is the coordination of cell junctions with actin cytoskeleton dynamics and membrane turnover.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036010","count":2},{"id":"GO:1990182","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0043297","count":2},{"id":"GO:0090136","count":2}]},{"hash":"571966486658931077","title":"Unknown","description":"The GO terms appear to span diverse biological contexts (developmental processes like notochord morphogenesis, axis specification, erythrocyte development, and spermatid elongation) as well as unrelated terms (plant hormone response, antisense RNA decay, apoptotic cell recognition, and obsolete histone modification terms). There isn\u2019t a single coherent functional theme tying the cluster together, so a concise, representative label cannot be robustly assigned.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043654","count":3},{"id":"GO:0009741","count":2},{"id":"GO:0032525","count":2},{"id":"GO:0018395","count":2},{"id":"GO:0048570","count":2}]},{"hash":"2189806445851662301","title":"Embryonic brain and limb morphogenesis","description":"The top GO terms cluster around embryonic development and morphogenesis of neural tissues and limbs (forebrain morphogenesis, cerebral cortex GABAergic interneuron differentiation, embryonic forelimb and hindlimb morphogenesis, eye morphogenesis, amacrine cell differentiation). This suggests a developmental/neurogenesis theme. A couple of terms (anthocyanin biosynthesis and regulation of B cell receptor signaling) appear as outliers, likely due to annotation noise. Overall, the cluster best fits embryonic brain and limb morphogenesis.","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":4},{"id":"GO:0055114","count":4},{"id":"GO:0050859","count":3},{"id":"GO:0048048","count":2},{"id":"GO:0007479","count":2}]},{"hash":"1014524772350096013","title":"Embryonic Morphogenesis","description":"The top GO terms cluster around development and morphogenesis across multiple tissues (eye, heart, forebrain, hindlimb, habenula, placenta, prostate gland morphology, and related embryonic structures), indicating a shared role in embryonic morphogenesis rather than a single tissue-specific function. This justifies a concise label that reflects a general developmental theme.","confidence":"High","size":12,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":8},{"id":"GO:0007507","count":8},{"id":"GO:2000288","count":8},{"id":"GO:0060527","count":8},{"id":"GO:0021986","count":8}]},{"hash":"2108844105975443411","title":"Steroid and lipid metabolism with xenobiotic detox","description":"The top terms cluster around steroid and lipid pathways (cortisol biosynthesis, bile acid and cholesterol metabolism, oxylipin production) and detox/fatty-acid\u2013related P450 activity, along with stress and hormone-driven development signals (response to ozone, sex differentiation, mammary gland development). This suggests a coherent theme of lipid/hormone metabolism coupled with detoxification processes.","confidence":"Medium","size":12,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010193","count":8},{"id":"GO:0031408","count":8},{"id":"GO:0007548","count":7},{"id":"GO:0034651","count":7},{"id":"GO:2001037","count":7}]},{"hash":"32015616010162806","title":"Xenobiotic Response and Biosynthetic Metabolism","description":"The GO terms indicate responses to xenobiotics (including cocaine) and several biosynthetic processes (cobalamin, sterol, antibiotic biosynthesis) along with carbohydrate phosphorylation, suggesting a theme of metabolizing foreign compounds while supporting key biosynthetic pathways.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009236","count":3},{"id":"GO:0046835","count":3}]},{"hash":"1305473704773554333","title":"Histone acetylation and transcription regulation","description":"This cluster is dominated by histone acetylation and chromatin modification terms (H4-K8, H4-K12, H2A acetylation) along with transcriptional regulation via RNA polymerase I, with a few apoptosis and cell proliferation terms that are likely downstream effects. The strongest signal is chromatin modification linked to gene expression control, justifying a label centered on histone acetylation and transcription regulation.","confidence":"High","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006893","count":1},{"id":"GO:0043982","count":1},{"id":"GO:0008285","count":1},{"id":"GO:1900404","count":1},{"id":"GO:0043968","count":1}]},{"hash":"2076854202817094366","title":"Nitric Oxide\u2013Mediated Vascular and Erythrocyte Regulation","description":"The cluster centers on nitric oxide biology, with terms for NO biosynthesis and transport, nitrosative stress response, and regulation of blood pressure, together with erythrocyte maturation and oxidant detoxification. Bicarbonate transport also ties into blood gas and vascular function, suggesting a cohesive NO-driven vascular/red blood cell regulatory theme, with a metabolic angle hinted by brown fat differentiation.","confidence":"High","size":12,"edges":13,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":3},{"id":"GO:0050873","count":3},{"id":"GO:0032966","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0051409","count":2}]},{"hash":"1924864677836963565","title":"Metazoan embryogenesis and morphogenesis","description":"Top GO terms cluster around embryonic development, axis specification, morphogenesis, cuticle/ molting processes, proteolysis, and reproductive steps across metazoans, suggesting a broad developmental program rather than a single pathway. This justifies a label capturing embryogenesis and morphogenesis across animals as the core theme for this cluster.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":4},{"id":"GO:0018996","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0007313","count":4},{"id":"GO:2000360","count":4}]},{"hash":"1418089448211146765","title":"Neural development and synaptic signaling","description":"Co-occurring GO terms point to glutamatergic signaling, nervous system development, synapse regulation, and axon guidance, with calcium homeostasis supporting neural activity, indicating a neural development/synaptic function cluster.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":2},{"id":"GO:0051563","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0060672","count":2}]},{"hash":"1225437845109734675","title":"Glutamatergic synapse development and neural morphogenesis","description":"The top GO terms point to ionotropic glutamate receptor signaling and regulation of synapse structure/activity, together with nervous system development and axon guidance, which together suggest a cluster focused on neural development and synaptic formation/maintenance. Some terms about morphogenesis in other tissues and amyloid fibril formation appear incidental but do not negate the central neural theme.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":2},{"id":"GO:0051563","count":2},{"id":"GO:0010951","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0060672","count":2}]},{"hash":"1976021693938967814","title":"Muscle cytoskeleton and sarcomere organization","description":"The top GO terms cluster around muscle structure and cytoskeletal organization: actin crosslink formation, sarcomere organization, and focal adhesion assembly, with supporting muscle-related processes like skeletal muscle atrophy and smooth muscle chemotaxis, plus baroreceptor-regulated blood pressure. These together point to a theme of muscle cell structure and cytoskeletal assembly, even though a few terms are more peripheral. ","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021564","count":1},{"id":"GO:0014732","count":1},{"id":"GO:1903478","count":1},{"id":"GO:0051764","count":1},{"id":"GO:0007182","count":1}]},{"hash":"1728720164347671127","title":"Unknown","description":"The top terms span nuclear DNA replication/repair/recombination and translation, plus mitochondrial tRNA aminoacylation, with additional development-related terms like keratinocyte proliferation and imaginal disc morphogenesis. There isn't a single coherent functional theme tying these terms together, suggesting the cluster may reflect diverse or incidental annotations rather than a specific shared function. ","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0070212","count":2},{"id":"GO:0043616","count":2},{"id":"GO:0007480","count":2},{"id":"GO:0006281","count":1}]},{"hash":"967007714744247609","title":"ER folding and secretory trafficking","description":"The top GO terms cluster around the endoplasmic reticulum (unfolded protein response, ER localization, COPII vesicle budding), pointing to roles in ER protein processing and trafficking through the secretory pathway. Some other terms (thiamine metabolism, root development) appear less related and may be incidental. With ER-related functions dominating, this label is representative, though the small size and noise keep confidence at a moderate level.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042357","count":1},{"id":"GO:0048364","count":1},{"id":"GO:0006772","count":1},{"id":"GO:0006171","count":1},{"id":"GO:0044828","count":1}]},{"hash":"349369619056800387","title":"Neuronal amino acid transport","description":"The cluster centers on import and transport of amino acids across membranes (D-aspartate, L-glutamate, serine, threonine), along with transmembrane transport in general. The presence of a brain-derived neurotrophic factor receptor signaling pathway suggests a neuronal context, consistent with neurotransmitter amino acid handling and metabolism. While a few terms are less directly tied (e.g., vacuolar acidification), the dominant theme is amino acid transport relevant to neural function.","confidence":"High","size":11,"edges":26,"triangles":24,"max_degree":9,"top_function":"transmembrane transport","top_go_terms":[{"id":"GO:0070779","count":3},{"id":"GO:0009449","count":3},{"id":"GO:0015826","count":3},{"id":"GO:0051938","count":3},{"id":"GO:0032329","count":3}]},{"hash":"95019820426364802","title":"Brain dopaminergic signaling and visual processing","description":"The cluster centers on neural signaling motifs: dopaminergic synaptic transmission, GPCR internalization, and ERK signaling, with related terms for visual perception and visual learning. The inclusion of morphine response and prostaglandin signaling aligns with neuromodulatory pathways in the brain, while a couple terms touch on vascular or immune processes. Overall, the dominant theme is brain-associated signaling and visual/dopaminergic function.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0002031","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0010759","count":2},{"id":"GO:0045907","count":2},{"id":"GO:0043278","count":2}]},{"hash":"964562741995818442","title":"Neuronal signaling and synaptic regulation","description":"The top GO terms are dominated by neural and synaptic processes: dopaminergic receptor signaling, negative regulation of synaptic transmission, synaptic vesicle budding, and visual perception. Metabolic signaling (glucose-mediated) also aligns with neuronal activity. While cell cycle and heart development terms appear, the strongest and most coherent theme is neural signaling and synaptic function, which justifies the name. ","confidence":"Medium","size":11,"edges":51,"triangles":133,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0050908","count":11},{"id":"GO:0051301","count":11},{"id":"GO:0007191","count":11},{"id":"GO:0050805","count":11},{"id":"GO:0007049","count":11}]},{"hash":"733340480715838525","title":"Diverse substrate membrane transporters","description":"These proteins are all linked to transmembrane transport across membranes for a variety of substrates, including ions (sodium, potassium), nitrates/nitrites, sugars (arabinose), vitamins, sialic acid, phenylacetate derivatives, and xenobiotics. The common theme is membrane transport rather than a single substrate or pathway, suggesting a family of multisubstrate transporters. ","confidence":"Medium","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015706","count":1}]},{"hash":"1285275962735090502","title":"Neural Signaling and Behavioral Response","description":"The cluster\u2019s top GO terms are dominated by neural-related signaling and behavioral outputs, such as sensory perception of pain, behavioral fear response, behavioral response to cocaine, regulation of membrane potential, and ERK1/ERK2 cascade, suggesting a theme of neural signaling leading to behavior. There are additional, more pleiotropic terms (heart development, sperm capacitation, macrophage chemotaxis, transcription regulation, thermogenesis) that indicate broader signaling roles, but the neural-behavioral signals appear most prominent. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0042391","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0048240","count":2},{"id":"GO:0007507","count":2}]},{"hash":"985024041925898638","title":"Monoaminergic GPCR-cAMP Signaling","description":"This cluster is dominated by terms related to dopamine and octopamine/tyramine signaling, including adenylate cyclase activation and regulation of PKA, pointing to monoaminergic G protein-coupled receptor pathways. A few terms about inflammation, development, and urine volume appear peripheral, but the core pattern strongly supports monoaminergic GPCR-cAMP signaling as the representative function.","confidence":"Medium","size":11,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1},{"id":"GO:0031649","count":1},{"id":"GO:0002032","count":1}]},{"hash":"320414031487512727","title":"Face morphogenesis","description":"Top GO term is face morphogenesis (GO:0060325), suggesting the proteins collectively relate to the development and shaping of facial features. The network shows a cohesive set of interactions among 11 proteins (28 edges, 36 triangles), reinforcing a shared role in this morphogenetic process.","confidence":"Medium","size":11,"edges":28,"triangles":36,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1}]},{"hash":"640903822807270194","title":"Unknown","description":"GO terms are highly diverse across this set, including Schwann cell development, kinetochore localization, snoRNA metabolism, epithelial-to-mesenchymal transition, xenobiotic response, meiotic DSB formation in recombination, ER-Golgi transport, and glycogen biosynthesis regulation. With no shared pathway or functional module evident and no network connectivity (edges/triangles = 0), there is no clear common theme tying these proteins together. Therefore, the cluster is best labeled Unknown.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032516","count":1},{"id":"GO:0014044","count":1},{"id":"GO:0034501","count":1},{"id":"GO:0016074","count":1},{"id":"GO:0001837","count":1}]},{"hash":"1809478102158422161","title":"Actin cytoskeleton remodeling and adhesion signaling","description":"This cluster\u2019s terms cluster around actin cytoskeleton dynamics (dendritic spine maintenance, postsynaptic actin changes) and adhesion-related processes (focal adhesion assembly), coupled with signaling pathways (PI3K/AKT, cytokine response). Although development terms appear, the common thread is cytoskeletal remodeling linked to intracellular signaling across diverse contexts such as immune differentiation and neuronal connectivity.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0030854","count":1},{"id":"GO:0045651","count":1},{"id":"GO:2001237","count":1},{"id":"GO:0048041","count":1}]},{"hash":"1810700184814530241","title":"Rho/Rac-Driven Cytoskeletal Remodeling","description":"This cluster centers on actin cytoskeleton dynamics, with strong signals for filopodium and lamellipodium assembly and regulation of Rac and Rho GTPases, indicating a shared role in adhesion-dependent cell spreading. Although immune and heart-development terms appear, the cohesive theme is cytoskeletal remodeling governed by Rho family GTPases.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900026","count":10},{"id":"GO:0046847","count":10},{"id":"GO:0007264","count":10},{"id":"GO:0007507","count":9},{"id":"GO:0032633","count":9}]},{"hash":"1001012589256108600","title":"Unknown","description":"The top GO terms are very diverse (osmotic response, water homeostasis, collagen organization, cholesterol endocytosis, exocytosis regulation, wound healing, T-helper 1 differentiation, and gliogenesis), with only one gene each, giving no clear shared function or pathway to define a cohesive cluster label.","confidence":"","size":11,"edges":48,"triangles":115,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000733","count":1},{"id":"GO:0009414","count":1},{"id":"GO:0009992","count":1},{"id":"GO:0099132","count":1},{"id":"GO:0030199","count":1}]},{"hash":"394652923627924578","title":"Plant cuticle biosynthesis and symbiont immune modulation","description":"The cluster is dominated by GO terms for cutin and suberin biosynthesis, indicating epidermal barrier formation (plant cuticle/suberin). There are also terms about symbiont-mediated suppression of host immune responses and regulation of tolerance, supporting a theme of immune modulation during plant\u2013microbe interactions. Additional terms on ubiquitination and ion transport align with signaling and transport activities in barrier/immune contexts. Despite one cross-kingdom term, the core pattern points to epidermal biosynthesis tied to immune tolerance in symbiosis.","confidence":"Medium","size":11,"edges":29,"triangles":25,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:1900490","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0010143","count":1}]},{"hash":"1471827022348929321","title":"Unknown","description":"The terms span broad transcription and multiple developmental or signaling contexts (muscle and pancreas development, IL-4 response, apoptosis regulation, even insect pigmentation) with no single unifying function, so a specific, cohesive label cannot be reasonably assigned.","confidence":"","size":11,"edges":31,"triangles":57,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":6},{"id":"GO:0035914","count":4},{"id":"GO:0071353","count":4},{"id":"GO:0071866","count":4},{"id":"GO:0031018","count":4}]},{"hash":"2273673183948398072","title":"Mitotic Regulation and Cell Polarity","description":"The top GO terms emphasize mitotic cell cycle, exit from mitosis, division-related processes, maintenance of cell polarity, and responses to mechanical stimuli, with supporting roles for protein ubiquitination and oligomerization. This points to a cohesive theme of coordinating cell division with polarity and cytoskeletal remodeling, potentially in contexts such as wound healing and neuronal projection dynamics.","confidence":"Medium","size":11,"edges":11,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0044319","count":2},{"id":"GO:0031175","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0016567","count":2}]},{"hash":"686074488313220350","title":"Embryonic organ development and morphogenesis","description":"GO terms indicate morphogenesis and development across multiple organs (embryonic digestive tract, neural crest, ureteric bud/kidney, pancreas, uterus, inner ear, placenta) plus differentiation and transcription regulation, suggesting a broad developmental program rather than a single pathway. This makes Embryonic organ development and morphogenesis an appropriate, representative label.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048557","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0001755","count":2},{"id":"GO:0090190","count":2},{"id":"GO:0031018","count":2}]},{"hash":"1944888229078481427","title":"RNA processing and translation regulation","description":"The GO terms cluster around RNA metabolism: splicing regulation, mRNA export, small-subunit processome involvement, and translation initiation/reinitiation, including preinitiation complex formation and stress-related mRNA stability. This indicates a coherent theme of RNA processing coupled with control of translation, including viral initiation contexts.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075522","count":3},{"id":"GO:0000381","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0006446","count":3},{"id":"GO:0010610","count":3}]},{"hash":"1574048052466354266","title":"RNA Modification and Transcriptional Regulation under Stress","description":"The cluster includes RNA modification (rRNA and tRNA wobble U), protein arginine methylation, and transcriptional regulation, along with stress- and metabolism-related processes (senescence, xenobiotic response, sterol/ubiquinone biosynthesis), indicating a module balancing gene expression with RNA maturation and metabolic remodeling under stress.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0090398","count":2},{"id":"GO:0016126","count":2},{"id":"GO:0046690","count":2},{"id":"GO:0019919","count":2}]},{"hash":"237458139709155990","title":"Translation initiation and ribosome biogenesis","description":"The cluster is enriched for translation and ribosome\u2013related GO terms (initiation, preinitiation complex formation, and ribosomal subunit biogenesis/export), indicating involvement in the translational machinery and ribosome assembly.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006413","count":2},{"id":"GO:0001732","count":2},{"id":"GO:0006446","count":2},{"id":"GO:0075525","count":2}]},{"hash":"1474944508702169974","title":"Developmental and reproductive processes","description":"The top GO terms point to developmental biology across species, including embryonic axis specification, morphogenesis, and fertilization-related regulation (polyspermy prevention, sperm\u2013zona binding) as well as organism-specific developmental processes like molting/cuticle formation and pharyngeal pumping. The shared theme is broad development and reproduction rather than a single, tight pathway, so a general developmental label fits with moderate confidence.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0007313","count":2},{"id":"GO:2000360","count":2}]},{"hash":"1198193097339783918","title":"Facial Morphogenesis and Cartilage Development","description":"The top GO terms are dominated by face morphogenesis and cartilage-related processes (growth plate cartilage development, endochondral ossification), suggesting proteins involved in craniofacial development and skeletal formation. Proteolysis and wound healing further imply extracellular matrix remodeling during tissue morphogenesis. Some metabolic terms appear peripheral, but the core signal points to craniofacial cartilage formation and remodeling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":4},{"id":"GO:0006508","count":2},{"id":"GO:1901750","count":1},{"id":"GO:0006750","count":1},{"id":"GO:0006751","count":1}]},{"hash":"204463419333658553","title":"Ribosome biogenesis and translation","description":"The top GO terms cluster around protein synthesis and ribosome assembly\u2014translation (GO:0006412), DNA-templated transcription (GO:0006351), ribosome biogenesis (GO:0042254), and ribosomal large subunit assembly (GO:0000027)\u2014suggest proteins involved in making ribosomes and supporting gene expression. Additional terms related to RNA metabolism (CRD-mediated mRNA stabilization and miRNA catabolic process) and cell division align with a broader role in growth and RNA processing linked to ribosome function. Some metabolic and stress-related terms are present but secondary to the core theme of ribosome biogenesis and translation.","confidence":"High","size":11,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0006351","count":2},{"id":"GO:0000027","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0042254","count":2}]},{"hash":"220729345490240503","title":"Muscle and Heart Development with Calcium Signaling","description":"The top terms point to muscle lineage and heart formation (myoblast fusion, heart development) and calcium-responsive signaling, with additional signaling roles in synaptic vesicle exocytosis and Rho pathways. This suggests a cluster focused on developmental signaling in muscle/heart tissues with calcium-mediated responses, rather than a single specific function.","confidence":"Medium","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0007520","count":3},{"id":"GO:0007507","count":2},{"id":"GO:0001302","count":2}]},{"hash":"1288308982715799122","title":"Neuronal Neurotransmission and Synaptic Plasticity","description":"This cluster is most strongly characterized by terms tied to neural communication: synaptic vesicle exocytosis, neurotransmitter secretion/transport, and positive regulation of synaptic plasticity, suggesting a core theme of neuronal signaling and synaptic function. Additional terms for secretory processes like insulin secretion and broader secretory roles are present but appear secondary to the dominant neuronal signaling signals, with occasional peripheral processes such as lipid transport and endothelial activation as less central associations.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060546","count":2},{"id":"GO:0016079","count":1},{"id":"GO:0046928","count":1},{"id":"GO:0030073","count":1},{"id":"GO:0006836","count":1}]},{"hash":"1468008470779601639","title":"Mitochondrial Transport and Energy Metabolism","description":"This cluster centers on mitochondrial function: membrane potential regulation, ATP transport, malate-aspartate shuttle, and transport of nucleotides and cofactors (pyrimidines, TPP, heme) into mitochondria, pointing to coordinated energy production and metabolic regulation. Insulin/IGF signaling responses and necroptosis regulation further tie metabolic state to growth and cell-survival pathways, with female pregnancy likely reflecting context-specific metabolic shifts. ","confidence":"High","size":11,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051881","count":4},{"id":"GO:0032869","count":4},{"id":"GO:1990519","count":3},{"id":"GO:0007565","count":3},{"id":"GO:0043490","count":3}]},{"hash":"1385573557951855757","title":"Ubiquitin-regulated Immune Signaling","description":"The cluster is unified by deubiquitination and immune signaling terms (protein deubiquitination; T cell receptor signaling; negative regulation of inflammatory response) and includes notes on Wnt pathway regulation and APC-dependent catabolic processes, all pointing to ubiquitin-mediated control of signaling and protein turnover in defense/immunity contexts. Plant hypersensitive response and viral process terms reflect broad defense-related regulation across species, reinforcing the immune-signaling module theme.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":8},{"id":"GO:0050852","count":6},{"id":"GO:0060071","count":6},{"id":"GO:0002862","count":6},{"id":"GO:0010363","count":6}]},{"hash":"1946277038518624854","title":"Embryonic Organ Development Regulators","description":"The proteins in this cluster point to diverse embryonic organogenesis processes across multiple tissues (heart, eye, brain, placenta, prostate) and include transcriptional regulation, suggesting a theme of developmental regulation rather than a single tissue-specific function.","confidence":"Medium","size":11,"edges":52,"triangles":139,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":3},{"id":"GO:0048048","count":3},{"id":"GO:0007507","count":3},{"id":"GO:2000288","count":3},{"id":"GO:0060527","count":3}]},{"hash":"595853215480172935","title":"Neuronal migration and synaptic receptor regulation","description":"The top terms point to neuronal development and movement (radial glia-guided migration, Purkinje and motor neuron migration, neuroblast division, leading edge differentiation) along with regulation of excitatory glutamate receptors (AMPA and NMDA) and receptor-mediated endocytosis linked to cholesterol transport. Collectively, these indicate a cluster of proteins involved in neuronal migration and modulation of synaptic receptor activity, with related membrane trafficking functions.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000311","count":1},{"id":"GO:0021813","count":1},{"id":"GO:2000310","count":1},{"id":"GO:0021849","count":1},{"id":"GO:0097477","count":1}]},{"hash":"431705776119330389","title":"Embryonic Development and Morphogenesis","description":"The cluster shows strong representation of developmental processes across multiple tissues (heart, skeletal muscle, cerebellum, retina, motor neurons), indicating a role in embryonic development and organ morphogenesis. Some DNA replication terms reflect proliferative aspects of development, supporting a broad developmental function rather than a single tissue-specific pathway.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007507","count":4},{"id":"GO:0048701","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0007601","count":3}]},{"hash":"700433075622995870","title":"Inflammation-linked nitrosative stress and metabolism","description":"The cluster shows a mix of inflammatory-related terms (response to lipopolysaccharide; response to nitrosative stress; peptidyl-cysteine S-nitrosylation) alongside a variety of metabolic processes (retinoic acid, prostaglandin, galactose, xylitol, ethanol catabolism). This suggests proteins involved in inflammatory signaling coupled with diverse metabolic pathways, rather than a single narrow function. Confidence: Medium","confidence":"","size":11,"edges":49,"triangles":117,"max_degree":10,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":8},{"id":"GO:0018119","count":6},{"id":"GO:0006116","count":6},{"id":"GO:0051409","count":6},{"id":"GO:0042573","count":6}]},{"hash":"2021208880228936669","title":"Mitotic regulation and ubiquitin-mediated proteolysis","description":"This cluster is dominated by terms tied to cell division and mitosis (cell division, mitotic spindle elongation) and by ubiquitin-related processes (K48-linked ubiquitination, positive regulation of polyubiquitination, regulation of ubiquitination). Together they suggest a module that coordinates mitotic progression with targeted protein degradation, with some obsolete terms present but not changing the main theme.","confidence":"High","size":11,"edges":54,"triangles":156,"max_degree":10,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051301","count":10},{"id":"GO:0051569","count":10},{"id":"GO:1902916","count":10},{"id":"GO:1904153","count":10},{"id":"GO:0033128","count":10}]},{"hash":"357004391293790180","title":"Unknown","description":"The top GO terms include diverse biosynthetic processes (sterol, mycolic acid, antibiotic, cobalamin), sensory/brain-related functions (sound perception, brain development, GABAergic synaptic transmission), differentiation (trophoblast giant cell), and other miscellaneous processes. There is no clear, unifying biological theme binding these terms across the 11 proteins, so a cohesive functional label is not supported.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016126","count":2},{"id":"GO:0071768","count":2},{"id":"GO:0017000","count":2},{"id":"GO:0009236","count":2},{"id":"GO:0007605","count":2}]},{"hash":"1662098605003491078","title":"Neural development and MAPK signaling","description":"The top GO terms cluster around nervous system development, brain/hippocampus development, indicating a neural development theme. Positive regulation of JNK and ERK cascades points to MAPK signaling involvement, a key pathway in neuronal differentiation and signaling. Additional terms on Golgi to plasma membrane transport and mechanical stimuli relate to neuronal cellular processes, while immune terms are present but less central. Overall, the cluster is best described as neural development with MAPK signaling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0006893","count":2},{"id":"GO:0032729","count":2}]},{"hash":"67410202315093405","title":"Immune cell signaling and cytoskeletal dynamics","description":"This cluster prominently features actin remodeling and Rho-mediated signaling (lamellipodium assembly, adhesion-dependent spreading) and is enriched for immune-related processes (B cell proliferation, thymus development, LPS signaling), with connections to secretory pathways (COPII cargo loading) and PI3K signaling, suggesting a cohesive theme of coordinated signaling and cytoskeletal regulation in immune and secretory contexts.","confidence":"Medium","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900026","count":6},{"id":"GO:0030890","count":6},{"id":"GO:0035023","count":6},{"id":"GO:0030032","count":6},{"id":"GO:1904424","count":6}]},{"hash":"1577267225557874417","title":"Diverse metabolism and transcription","description":"The top GO terms span both transcription-related processes (DNA-templated transcription; galactose-regulated transcription) and a wide array of metabolic pathways (TCA cycle, carbohydrate phosphorylation, galactose and galacturonate metabolism, isoprenoid biosynthesis via mevalonate and MEP pathways, threonine biosynthesis, and GDP-L-fucose salvage). This points to a cluster of proteins involved in broad primary metabolism with some transcriptional regulation signals, justifying a label that reflects both aspects.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006099","count":2},{"id":"GO:0046835","count":1},{"id":"GO:0000435","count":1},{"id":"GO:0019402","count":1}]},{"hash":"211798888456380630","title":"Unknown","description":"The top GO terms form a mixed bag of membrane transport, amino acid/homeostasis, glycosylation, and various development/behavior processes, with no single cohesive function tying the proteins together and no network connectivity to reinforce a shared pathway. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904659","count":1},{"id":"GO:0015811","count":1},{"id":"GO:0002088","count":1},{"id":"GO:0007625","count":1},{"id":"GO:0034488","count":1}]},{"hash":"1984293795984545583","title":"Transmembrane Transporters","description":"This cluster centers on transmembrane transport of a variety of ions and substrates (Na+, K+, nitrate, arabinose, vitamins, xenobiotics, microcystin, 4-hydroxyphenylacetate), indicating membrane transport proteins with broad substrate range rather than a single pathway.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043252","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0071805","count":3},{"id":"GO:1905431","count":2},{"id":"GO:0006855","count":2}]},{"hash":"331035807884512642","title":"Dopaminergic Signaling and Visual Perception","description":"This cluster is dominated by terms tied to dopamine-mediated neural signaling, sensory processing, and visual function (e.g., dopaminergic synaptic transmission, visual perception, visual learning, sensory perception of pain, cocaine response) along with ERK cascade signaling and protein phosphorylation. While a couple of terms (like heart development and macrophage chemotaxis) are less directly related to neural signaling, the prevailing pattern points to CNS dopaminergic signaling and sensory processing as the unifying theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0007507","count":8},{"id":"GO:0048148","count":8},{"id":"GO:0010759","count":8},{"id":"GO:0070374","count":8}]},{"hash":"2073797848127850219","title":"Mammary gland and reproductive development","description":"The top GO terms point to mammary gland development and lactose biosynthesis, with additional links to reproductive processes (acrosome reaction, development of secondary sexual characteristics) and tissue remodeling (angiogenesis in wound healing, epithelial cell proliferation). Glycosylation-related processes (keratan sulfate proteoglycan and glycosphingolipid biosynthesis) further support roles in extracellular matrix interactions during development. While there is broad developmental signaling across tissues (including neural development terms), the strongest cohesion is around mammary gland development and related reproductive processes, with supportive glycosylation and wound-healing contexts.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":2},{"id":"GO:0030879","count":2},{"id":"GO:0060055","count":2},{"id":"GO:0060058","count":2},{"id":"GO:0045136","count":2}]},{"hash":"356814422245604149","title":"Post-transcriptional RNA processing and translation control","description":"Proteins here cluster around RNA-level regulation: polyadenylation, splicing, deadenylation-dependent decay, and cytoplasmic translation, with supporting signals from p38 MAPK and inflammatory stress pathways. While some terms like heart development and bile acid metabolism appear elsewhere, the recurring themes are post-transcriptional processing and control of translation under stress. ","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":2},{"id":"GO:0050728","count":2},{"id":"GO:0006378","count":2},{"id":"GO:0034247","count":2},{"id":"GO:0002181","count":2}]},{"hash":"584729637949180104","title":"Multisystem Development","description":"This cluster\u2019s GO terms span ossification, skin development, ureter maturation, synapse assembly, dopaminergic neuron axon guidance, balance sensing, TGF-beta regulation, and cardiac action potential regulation. The common thread is broad developmental processes across multiple organ systems, rather than a single, cohesive pathway. Therefore the label Multisystem Development is a concise, representative name. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":2},{"id":"GO:0098911","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0050973","count":1},{"id":"GO:0060989","count":1}]},{"hash":"1478165835279501204","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000184","count":2},{"id":"GO:0060325","count":2},{"id":"GO:1903259","count":1},{"id":"GO:0006301","count":1},{"id":"GO:0006369","count":1}]},{"hash":"93949929957621000","title":"Neuronal apoptosis and calcium signaling","description":"The top GO terms emphasize apoptosis (apoptotic process and recognition of apoptotic cell) and neural context (brain development, regulation of synaptic plasticity) with a clear signal for calcium ion response, suggesting a theme around neural cell death/survival linked to calcium signaling. Some outliers (aging terms, B cell differentiation) are present but do not define the cluster's core function.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0043654","count":3},{"id":"GO:0015917","count":3},{"id":"GO:0001302","count":2},{"id":"GO:0031914","count":2}]},{"hash":"258369366770319189","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":15,"triangles":6,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0071038","count":4},{"id":"GO:0000467","count":4},{"id":"GO:0071051","count":4},{"id":"GO:0071049","count":4},{"id":"GO:0071042","count":4}]},{"hash":"1172061140163533646","title":"Multitissue Development and Differentiation","description":"The top GO terms point to development and differentiation across diverse tissues (female gonad, heart, cerebellum, kidney) along with supporting processes like exocytosis and cell-matrix adhesion. While not tied to a single pathway, the cluster appears to assemble proteins involved in developmental programs across multiple organ systems, rather than a specialized functional module.","confidence":"Medium","size":10,"edges":16,"triangles":8,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0008585","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0007160","count":2},{"id":"GO:0072284","count":2},{"id":"GO:0055011","count":2}]},{"hash":"705240201474973915","title":"Cerebellar development and transcriptional regulation","description":"Based on the GO terms, the cluster shows a cohesive signal around cerebellar neuron development (Purkinje cell migration, granule cell precursor proliferation) and broad regulation of gene expression (DNA-templated transcription, RNAP II regulation, chromatin-related modifications, and cell-cycle control). Some terms (pentose-phosphate shunt, viral process, obsolete terms) are peripheral, which lowers but does not negate the central theme. Therefore, the label reflects the strongest, most representative function of the cluster.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006098","count":2},{"id":"GO:0021942","count":2},{"id":"GO:0021930","count":2},{"id":"GO:1902499","count":2},{"id":"GO:0006351","count":2}]},{"hash":"2197534052881572759","title":"Mitochondrial Metabolite Transport","description":"Most terms describe transmembrane transport of metabolites and cofactors into or across the mitochondrial inner membrane (pyrimidine nucleotides, ATP, thiamine pyrophosphate, CoA, heme) and shuttle systems. This points to a cohesive role in mitochondrial transport/metabolism rather than a single signaling pathway. A few terms relate to IGF signaling or necroptosis regulation, which can tie to mitochondrial function, but the core theme is mitochondrial metabolite transport.","confidence":"High","size":10,"edges":14,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":3},{"id":"GO:0007565","count":3},{"id":"GO:0043490","count":3},{"id":"GO:1990544","count":3},{"id":"GO:0030974","count":3}]},{"hash":"55732823663244150","title":"Unknown","description":"The top GO terms span immune signaling (lipopolysaccharide response, T cell differentiation, MAPK cascade), metabolism (AMP salvage), and neural development (axonogenesis, synapse localization, retinoic acid response) plus transcriptional control, with no single cohesive theme and no interactions among proteins (edges) to link them. This suggests a heterogeneous collection rather than a coherent functional cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0046638","count":2},{"id":"GO:0044209","count":2},{"id":"GO:0003430","count":2},{"id":"GO:0090188","count":2}]},{"hash":"2041068348964145956","title":"Unknown","description":"The Top Terms span diverse cellular processes (endocytosis, heart development, cell cycle, reticulophagy, signaling) with only a couple of terms per function and no connectivity among proteins. There is no clear shared function tying the proteins together, so a coherent, high-confidence label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051291","count":2},{"id":"GO:0006897","count":2},{"id":"GO:0032966","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0006817","count":1}]},{"hash":"397304635039145508","title":"ER stress-induced apoptosis and protein quality control","description":"This cluster centers on ER stress responses: intrinsic apoptotic signaling in response to ER stress, ER-associated degradation, and ubiquitination, coupled with changes in translation initiation. These GO terms together point to a shared function in managing protein folding, synthesis, and degradation under stress, rather than a single well-defined process. Some terms (e.g., development or signaling unrelated to stress) are likely ancillary noise. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070059","count":3},{"id":"GO:0002188","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0001731","count":3},{"id":"GO:0070208","count":3}]},{"hash":"1006614446664037498","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009432","count":4},{"id":"GO:0042273","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0031124","count":3},{"id":"GO:0000390","count":3}]},{"hash":"936335094581265603","title":"Ubiquitin-Proteasome Regulation of the Cell Cycle","description":"The cluster is dominated by GO terms for ubiquitin-mediated protein degradation (SCF-dependent, K11-linked, APC/C-related) and cell-cycle transitions (G2/M), with associated processes like neddylation and autoubiquitination. This points to a cohesive theme of proteostasis governing mitosis and DNA repair, with a possible note that viral processes and development terms reflect broader ubiquitin-system roles. Overall, it represents regulation of cell cycle progression via the ubiquitin-proteasome-neddylation axis.","confidence":"High","size":10,"edges":31,"triangles":40,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0045116","count":4},{"id":"GO:0016032","count":4},{"id":"GO:0031145","count":4}]},{"hash":"1150904586229428614","title":"Telomere maintenance and DNA replication","description":"Proteins in this cluster are strongly tied to telomere maintenance and telomerase regulation, with additional connections to DNA replication dynamics (fork reversal and fork progression) and DNA repair, including mitochondrial genome maintenance. This combination points to a core theme of genome stability during replication and telomere maintenance, spanning nuclear and mitochondrial contexts.","confidence":"High","size":10,"edges":45,"triangles":120,"max_degree":9,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0051974","count":7},{"id":"GO:0000002","count":7},{"id":"GO:0032211","count":7},{"id":"GO:0000723","count":7},{"id":"GO:0044806","count":7}]},{"hash":"1407415723608961781","title":"Unknown","description":"Top terms include spliceosome assembly and catalytic steps, protein ubiquitination, cell division, and several development-related processes with no single shared function, suggesting the proteins cover multiple unrelated pathways rather than a coherent theme.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000349","count":1},{"id":"GO:0000387","count":1},{"id":"GO:0072327","count":1},{"id":"GO:2000495","count":1},{"id":"GO:0051301","count":1}]},{"hash":"219160702805240564","title":"Cytoskeletal remodeling and signaling in development and immunity","description":"The top GO terms point to actin crosslink formation and podosome assembly (cytoskeletal remodeling), JUN phosphorylation (signaling), and innate immune responses, with COPII vesicle cargo loading highlighting secretory trafficking. Developmental terms (cerebellum morphogenesis, bone development) suggest broad tissue involvement. Together, they indicate a cluster of proteins coordinating cytoskeleton dynamics, trafficking, and signaling in development and immune contexts.","confidence":"Medium","size":10,"edges":8,"triangles":0,"max_degree":3,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0021587","count":5},{"id":"GO:0060348","count":5},{"id":"GO:0045087","count":5},{"id":"GO:0007258","count":4},{"id":"GO:0090110","count":3}]},{"hash":"301933412636884949","title":"Embryonic Development and Morphogenesis","description":"The top GO terms indicate broad involvement in embryo development and tissue morphogenesis (in utero embryonic development, embryonic eye and hindlimb morphogenesis, mammary gland alveolus development, growth plate cartilage growth) and transcriptional regulation (DNA-templated transcription). These together suggest a cluster of proteins coordinating developmental programs during embryogenesis across multiple tissues, with transcriptional control as a central mechanism. Neuron maturation also fits under neurodevelopmental aspects of embryogenesis, supporting a cohesive developmental theme.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042551","count":4},{"id":"GO:0001701","count":4},{"id":"GO:0006351","count":3},{"id":"GO:0048048","count":2},{"id":"GO:0050680","count":2}]},{"hash":"1389471221703253605","title":"Collagen-Driven Organ Morphogenesis","description":"Most of the top GO terms point to collagen-related extracellular matrix processes (collagen fibril organization; collagen-activated tyrosine kinase receptor signaling) and developmental morphogenesis (endochondral ossification; camera-type eye morphogenesis). This pattern suggests proteins involved in ECM remodeling that supports tissue and organ development. Some terms (complement activation, sodium channel clustering, renal albumin absorption) are less central and may reflect broader or pleiotropic roles, but they do not override the core ECM/morphogenesis signal.","confidence":"Medium","size":10,"edges":10,"triangles":1,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001958","count":5},{"id":"GO:0033034","count":5},{"id":"GO:2000534","count":5},{"id":"GO:0038063","count":5},{"id":"GO:0001867","count":5}]},{"hash":"240960023707166025","title":"Cell Cycle Control and Actin Remodeling","description":"The top GO terms point to cell cycle processes (DNA-templated transcription, cell division, mitotic sister chromatid cohesion, regulation of cytokinesis) and actin cytoskeleton dynamics (Arp2/3-mediated actin nucleation, barbed-end capping). Some entries are obscure or obsolete, but the recurring themes suggest a cluster coordinating cell proliferation with cytoskeletal remodeling, with occasional differentiation signals (lens fiber). This supports a cohesive, albeit broad, theme of cell cycle control linked to actin regulation.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0051441","count":2},{"id":"GO:0008284","count":2},{"id":"GO:0007064","count":2}]},{"hash":"1772500900551167818","title":"Viral Entry, Replication, and Proviral Latency","description":"The top GO terms point to viral/symbiont interaction with host cells, including entry into the host nucleus, establishment of proviral latency, and DNA-level processes such as recombination, replication, and DNA integration, plus RNA-templated DNA biosynthesis. This pattern supports a theme of viral genome integration and maintenance within the host. A couple of terms (negative regulation of siRNA processing and plant cell wall cellulose biosynthesis regulation) appear less connected and may reflect annotation noise. Overall, the dominant signal is viral entry and proviral genome integration with host replication processes.","confidence":"Medium","size":10,"edges":34,"triangles":50,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2},{"id":"GO:0006310","count":2}]},{"hash":"1398243034992519903","title":"Diverse biosynthesis and lipid metabolism","description":"This cluster is dominated by GO terms indicating biosynthetic processes across a wide range of metabolites, including lipids (fatty acid elongation, mycolic acid, steroid hormone metabolism, retinal metabolism) and secondary metabolites (antibiotic and tropane alkaloid biosynthesis), plus PHB biosynthesis. The common theme is general biosynthetic and lipid-related metabolism rather than a single specific pathway, suggesting a label around broad biosynthesis with lipid emphasis. ","confidence":"Medium","size":10,"edges":9,"triangles":2,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042619","count":8},{"id":"GO:0055114","count":8},{"id":"GO:0017000","count":8},{"id":"GO:0042574","count":7},{"id":"GO:0071768","count":7}]},{"hash":"1165275578975599254","title":"Unknown","description":"The top GO terms are highly diverse (immune regulation, pollen recognition, vascular proteolysis/fibrinolysis, muscle development, mammary gland proliferation, signaling regulation, oxidative stress responses), with no clear shared pathway or function. Obsolete or vague terms further suggest noise rather than a cohesive biological theme, so a single representative label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010758","count":1},{"id":"GO:1902947","count":1},{"id":"GO:0048544","count":1},{"id":"GO:0051919","count":1},{"id":"GO:0045445","count":1}]},{"hash":"2157993613698267392","title":"Acetylation and Polyamine Metabolism","description":"The top GO terms are dominated by acetylation-related processes, including various acetylations of proteins (N-terminal, peptidyl-lysine, histone-related) and polyamine acetylation (putrescine, spermidine, spermine). This suggests the cluster groups enzymes/modifications involved in acetylation chemistry and polyamine metabolism, with a couple less-connected terms (e.g., leaf formation, glucosamine metabolism) that are peripheral. Overall, the acetylation theme best explains the shared function among these proteins.","confidence":"High","size":9,"edges":10,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009447","count":4},{"id":"GO:0032918","count":4},{"id":"GO:0045150","count":4},{"id":"GO:2000025","count":4},{"id":"GO:0043967","count":4}]},{"hash":"880475570032358628","title":"Inflammation and blood coagulation","description":"The cluster\u2019s top GO terms center on immune/hemostatic processes: blood coagulation, inflammatory response, response to lipopolysaccharide, and viral release from host cell, suggesting a core theme of innate immunity and clotting. Some terms (retina development, molting cycle, muscle regulation) appear less directly connected and may reflect annotation breadth or multi-function proteins, but the dominant signal is inflammation/coagulation. ","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007596","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0032496","count":2},{"id":"GO:0019076","count":2},{"id":"GO:0045907","count":2}]},{"hash":"1350321082226764742","title":"Neural plasticity and apoptosis regulation","description":"This cluster centers on neural signaling and synaptic modulation (potassium transport, long-term potentiation, and regulation of synaptic plasticity) alongside apoptosis control (positive and negative regulation) and glial-related processes; the presence of an interleukin-4 response hints at immune-glial interactions that can influence neural plasticity and survival, while an outlier term like keratinocyte differentiation may reflect broader context. Overall, the proteins appear to be involved in neural signaling with regulation of cell survival and glial responses.","confidence":"Medium","size":9,"edges":8,"triangles":1,"max_degree":6,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006813","count":4},{"id":"GO:0071353","count":3},{"id":"GO:0031914","count":3},{"id":"GO:0001324","count":3},{"id":"GO:0006915","count":3}]},{"hash":"1207289725718117681","title":"Triglyceride Metabolism and Osteoclast Signaling","description":"This cluster centers on triglyceride catabolism and related lipid metabolism (phospholipid/phosphatidylcholine catabolism) together with signaling pathways (PKA regulation and integrin signaling) and bone- remodeling related processes (osteoclast differentiation and prostaglandin biosynthesis), suggesting a link between lipid metabolism and osteoclast signaling in bone remodeling.","confidence":"Medium","size":9,"edges":9,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034638","count":3},{"id":"GO:2000480","count":2},{"id":"GO:0006642","count":2},{"id":"GO:0046338","count":2},{"id":"GO:0036153","count":2}]},{"hash":"1675628447741584220","title":"Cell surface signaling and junction assembly","description":"The top GO terms show a common theme around cell surface communication and junctions: receptor signaling, receptor internalization, and cell\u2013cell or cell\u2013matrix junction assembly (including smooth septate and paranodal junctions). Additional terms involve integrin and VEGF signaling, reinforcing a focus on membrane-associated signaling and adhesion. A stray term about photoreceptor differentiation slightly broadens the set, but the majority point to membrane signaling and junctional complexes, justifying a cohesive, albeit moderately broad, cluster label.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090528","count":1},{"id":"GO:0046813","count":1},{"id":"GO:0031623","count":1},{"id":"GO:1901223","count":1},{"id":"GO:0007166","count":1}]},{"hash":"2014227201323005920","title":"Mitochondrial Nucleotide and Cofactor Transport","description":"The GO terms cluster around transport and exchange across the mitochondrial membrane for nucleotides and cofactors (pyrimidine nucleotides, malate-aspartate shuttle, ATP, thiamine pyrophosphate, CoA, heme) and include related mitochondrial membrane potential regulation, indicating a cohesive theme of mitochondrial transport/maintenance and metabolism.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":7},{"id":"GO:0007565","count":7},{"id":"GO:0043490","count":7},{"id":"GO:1990544","count":7},{"id":"GO:0030974","count":7}]},{"hash":"946579177318101304","title":"mRNA decay and transcription regulation","description":"The Top Terms are dominated by deadenylation and decapping/mRNA decay processes, with supporting terms for poly(A) tail shortening and transcription elongation, suggesting a cluster centered on post-transcriptional mRNA turnover and its link to transcriptional control, with some developmental context.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001829","count":1},{"id":"GO:0031087","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0032968","count":1},{"id":"GO:0000289","count":1}]},{"hash":"1095693143119562719","title":"Unknown","description":"This cluster provides no evident shared GO terms or interaction signals (no edges, triangles, or top terms) to define a common function, so a meaningful label cannot be assigned.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1511086803288436794","title":"Neuronal signaling and ion transport","description":"The top GO terms predominantly point to neural communication and ion channel function, including GABA receptor clustering, excitatory postsynaptic potentials, regulation of action potentials, sodium ion transport, and sensory processing, with circadian regulation aligning to brain activity. While acrosome reaction and chondrocyte morphogenesis are less directly related, the shared theme across most terms is neuronal signaling and ion homeostasis. ","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":1},{"id":"GO:0060079","count":1},{"id":"GO:0045188","count":1},{"id":"GO:0097112","count":1},{"id":"GO:2001226","count":1}]},{"hash":"1546677516641413143","title":"Amino Acid and Cofactor Metabolism","description":"Top GO terms indicate biosynthesis and metabolism across amino acids (lysine, beta-alanine, L-alanine), cofactors (biotin, NADPH regeneration, glutathione), and central carbon metabolism (protoporphyrinogen IX biosynthesis, 2-oxoglutarate, TCA cycle), with a translation term also present. The common theme is synthesis and turnover of amino acids and cofactors along with core metabolic pathways. This justifies a label centered on amino acid and cofactor metabolism.","confidence":"Medium","size":9,"edges":13,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0019878","count":3},{"id":"GO:0006782","count":3},{"id":"GO:0006412","count":2},{"id":"GO:0009102","count":2},{"id":"GO:0019483","count":2}]},{"hash":"754504608231528104","title":"Neural stress signaling and transport","description":"The cluster shows enrichment for neural-related responses, including vocalization behavior, estradiol response, and responses to high light, UV-A, and heat, plus activation of the stress-activated MAPK cascade, and processes related to anterograde axonal transport and regulation of intracellular transport. Together these terms point to proteins involved in neural signaling under environmental and hormonal stress, with a transport component driving the neural communications. Confidence: Medium","confidence":"","size":9,"edges":9,"triangles":1,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0071625","count":4},{"id":"GO:0032355","count":2},{"id":"GO:0009644","count":2},{"id":"GO:0070141","count":2},{"id":"GO:0007568","count":2}]},{"hash":"916945173515491623","title":"Vacuolar trafficking and proton transport","description":"The cluster contains several GO terms tied to the vacuole (vacuole organization, protein targeting to vacuole, vacuolar acidification) and proton-related transport/energy functions (proton transmembrane transport, proton motive force-driven plasma membrane ATP synthesis), suggesting a cohesive role in vacuolar protein sorting and proton-driven energetics. Other terms like translation and spliceosome activity appear less central to this cluster but may reflect background housekeeping annotations.","confidence":"Medium","size":9,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:1990416","count":2},{"id":"GO:0000388","count":2},{"id":"GO:0006814","count":1},{"id":"GO:0006626","count":1}]},{"hash":"408305156310776501","title":"Growth and Cell Cycle Regulation with NF-kappaB Modulation","description":"The cluster is dominated by growth-related GO terms (regulation of growth, multicellular organism growth) and cell cycle terms, indicating a focus on proliferation control. The inclusion of canonical and non-canonical NF-kappaB regulation suggests modulation of inflammatory signaling linked to growth and division. Additional terms related to oxidative phosphorylation and nuclear protein export indicate coordinated regulation of metabolism and gene expression that support cell growth. Therefore, name reflects growth and cell cycle regulation with NF-kappaB modulation.","confidence":"High","size":9,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0040008","count":2},{"id":"GO:0035264","count":2},{"id":"GO:0043124","count":2},{"id":"GO:1903705","count":1},{"id":"GO:0007049","count":1}]},{"hash":"2273999540095211182","title":"Ubiquitination and Histone Turnover","description":"The top GO terms are dominated by ubiquitin-related processes: ubiquitin-dependent protein catabolic process, autoubiquitination, K6-linked ubiquitination, and regulation of protein sumoylation, plus histone catabolic processes including histone ubiquitination. Together these suggest a coherent module focused on tagging proteins for degradation and histone turnover/modification, with TNF signaling and apoptosis regulation as supportive connections to ubiquitin pathways.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903265","count":2},{"id":"GO:0042787","count":2},{"id":"GO:0036205","count":2},{"id":"GO:0085020","count":2},{"id":"GO:0051865","count":2}]},{"hash":"62942014904635947","title":"Ribosome biogenesis and translation","description":"Dominant GO terms center on ribosome assembly and protein synthesis (translation, ribosome biogenesis, preribosome assembly, large subunit biogenesis). These terms suggest proteins involved in ribosome maturation and translation machinery. A few scattered terms refer to transcription termination and SOS response, which may reflect broader cellular stress signaling or annotation noise, but do not outweigh the ribosome-focused signal.","confidence":"High","size":9,"edges":35,"triangles":77,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0009432","count":2},{"id":"GO:0006369","count":2},{"id":"GO:1902626","count":2}]},{"hash":"1662768429527195045","title":"Unknown","description":"The annotated terms span transcription, kinase signaling, immune activation, behavior, and host interaction with no dominant theme, and there are no edges connecting the proteins, so no cohesive functional module is evident.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032147","count":1},{"id":"GO:1902064","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0043542","count":1},{"id":"GO:0060244","count":1}]},{"hash":"381613917740904060","title":"Craniofacial development and neural crest","description":"This cluster is dominated by GO terms related to face morphogenesis and neural crest cell development, pointing to a craniofacial development theme. The presence of related calcium signaling and cytoskeletal terms may reflect the cellular processes that accompany morphogenesis, but the core signal is craniofacial/neural crest\u2013driven development.","confidence":"Medium","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0051764","count":1},{"id":"GO:0051562","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0010880","count":1}]},{"hash":"2113858357175308080","title":"Nitric Oxide Signaling and Nitrosative Stress in Blood","description":"The cluster centers on GO terms related to nitric oxide production, transport, and nitrosative stress, along with regulation of blood pressure and bicarbonate transport, which points to a coordinated NO-mediated cardiovascular/erythrocyte function. A couple of outlier terms (e.g., nitrogen fixation, regulation of collagen biosynthesis) are present but don\u2019t redefine the main theme.","confidence":"High","size":9,"edges":10,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0032966","count":2},{"id":"GO:0043249","count":2},{"id":"GO:0051409","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0015701","count":2}]},{"hash":"748864816310640864","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903026","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0097428","count":1},{"id":"GO:0036494","count":1},{"id":"GO:0071630","count":1}]},{"hash":"1038202354069953529","title":"Plant light signaling and circadian regulation","description":"The main GO terms cluster around plant light perception and signaling (far-red signaling, phototransduction), and circadian rhythm regulation, including seed germination control, suggesting a cohesive theme of light-responsive transcriptional regulation in plants. Some metabolism-related terms appear, but the dominant pattern points to light sensing and circadian control of gene expression.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042753","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0009585","count":1},{"id":"GO:0010124","count":1}]},{"hash":"1787380777157004209","title":"Embryonic brain and eye morphogenesis","description":"The top GO terms cluster around neural development and ocular formation (forebrain and cerebral cortex interneuron differentiation, globus pallidus development, embryonic eye morphogenesis, amacrine cell differentiation) with supporting retinoic acid/metabolic regulation terms. Together they point to coordinated embryonic neural/retinal morphogenesis, justifying a label focused on brain and eye development.","confidence":"High","size":9,"edges":9,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":5},{"id":"GO:0021759","count":5},{"id":"GO:0048048","count":4},{"id":"GO:0007479","count":4},{"id":"GO:0048853","count":4}]},{"hash":"1048538034505597602","title":"Isoprenoid biosynthesis and protein prenylation","description":"The top GO terms include protein farnesylation and geranylgeranylation, as well as hopanoid and tuberculosinol biosynthesis, all pointing to isoprenoid metabolism and lipid modification. Despite a few unrelated annotations, the strongest signal ties to prenylation-related processes and isoprenoid biosynthesis, suggesting these proteins function in this pathway. ","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018343","count":1},{"id":"GO:0045787","count":1},{"id":"GO:0010035","count":1},{"id":"GO:0008285","count":1},{"id":"GO:0051770","count":1}]},{"hash":"2246475004990805776","title":"Transmembrane Ion Transporters (Na+/K+/Li+)","description":"Based on the GO terms, the proteins are enriched for sodium, potassium, and lithium ion transmembrane transport, indicating a cluster of membrane transport proteins specialized in inorganic cation movement. Other terms present are sporadic or obsolete and likely represent annotation noise, but the dominant signal is ion transport across membranes.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0043686","count":1},{"id":"GO:0006516","count":1},{"id":"GO:0018279","count":1}]},{"hash":"1619321315852225037","title":"Membrane nutrient and xenobiotic transporters","description":"The top GO terms are dominated by various transmembrane transport activities for nutrients and xenobiotics (nitrate, phosphate, potassium, vitamins, trehalose, fucose, xenobiotics) and related osmotic stress response, indicating a cohesive set of transport proteins mediating uptake/export of diverse substrates and adaptation to osmotic changes.","confidence":"High","size":9,"edges":16,"triangles":10,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":7},{"id":"GO:0042908","count":6},{"id":"GO:0071805","count":6},{"id":"GO:0006855","count":6},{"id":"GO:0035461","count":6}]},{"hash":"1041005524508897487","title":"Male gonad and prostate development","description":"The top GO terms show a strong emphasis on male reproductive organ development, notably male gonad development and differentiation of the prostate glandular acinus, which suggests the cluster centers on male reproductive development. Other terms indicate general cellular processes (transcription, cell division, mRNA transport, ubiquitination) that accompany development but are not as specific, so the developmental theme is most representative.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008584","count":4},{"id":"GO:0060528","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0035264","count":4},{"id":"GO:0051301","count":3}]},{"hash":"2091184773726347160","title":"Flavonoid and lignin biosynthesis","description":"Top terms are dominated by anthocyanin biosynthesis, kaempferol O-glucoside biosynthesis, and lignin metabolism, all core phenylpropanoid pathways in plants. Additional terms point to glycosylation and detoxification-related metabolism, with a few outliers like cell cycle or paranode localization that may reflect noise. Overall, the cluster centers on plant secondary metabolism via flavonoid and lignin biosynthesis.","confidence":"Medium","size":9,"edges":17,"triangles":11,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009718","count":9},{"id":"GO:0051301","count":8},{"id":"GO:0052697","count":8},{"id":"GO:0007049","count":8},{"id":"GO:0016999","count":8}]},{"hash":"1690999863787400163","title":"Growth signaling and cell cycle regulation","description":"The GO terms cluster around nutrient-sensing and growth pathways (TORC1 signaling, cellular response to amino acids) together with regulators of GTPase activity, DNA replication, meiosis, and morphogenesis. Nuclear import and ciliary docking terms suggest broader cellular organization within this regulatory network. Collectively, they point to a theme of growth control and developmental signaling affecting cell division and development rather than a single enzymatic function.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0038202","count":2},{"id":"GO:0097711","count":2},{"id":"GO:0060188","count":2}]},{"hash":"1562028511633345795","title":"Ubiquitin-Dependent Muscle Protein Turnover","description":"The dominant GO terms point to ubiquitin-mediated protein catabolism and muscle-related processes (sarcomere organization, skeletal muscle differentiation, and regulation of ubiquitination), suggesting a cluster of proteins involved in muscle protein turnover via ubiquitin pathways. Some terms are less related, but the core signal supports a muscle proteostasis theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051260","count":3},{"id":"GO:0042752","count":3},{"id":"GO:0019762","count":2},{"id":"GO:0035914","count":2}]},{"hash":"1989084623745015969","title":"Unknown","description":"The GO terms cover vesicle transport (Golgi to ER), regulation of GTPase activity, ER-stress\u2013related apoptosis, transcription, and broad developmental processes (skeletal development, neural tube closure, multicellular development, growth hormone response, imprinting-related expression, and mitotic cell cycle). This mix spans cellular trafficking, signaling, gene regulation, and development without a single coherent function linking the proteins, so no clear cluster function emerges.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006890","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0070059","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1003489356908678449","title":"Unknown","description":"The term set is highly diverse, including mitochondrial protein import (GO:0045039, GO:0006626, GO:0072321), DNA repair (GO:0006289), rRNA transcription (GO:0006360), cytoskeletal dynamics (GO:0007019), glial differentiation (GO:0045687), and inflammatory signaling (GO:0071346, GO:1900017). With no single unifying function or pathway across these terms, there isn't a clear, representative label for the cluster.","confidence":"","size":8,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045039","count":1},{"id":"GO:0006626","count":1},{"id":"GO:0072321","count":1},{"id":"GO:0006289","count":1},{"id":"GO:0006360","count":1}]},{"hash":"412501895416652554","title":"Mitotic Cycle and COPII Vesicle Trafficking","description":"This cluster has strong representation of mitosis-related GO terms (cell division, mitotic cell cycle, mitotic spindle assembly, cell population proliferation) alongside COPII vesicle budding and retrograde Golgi-to-ER transport, suggesting a link between cell cycle progression and secretory pathway dynamics. The presence of transcription and ribosome biogenesis/translation terms may reflect general housekeeping functions common to proliferating cells, but the consistent mitosis and trafficking signals dominate the theme. Therefore, the combined emphasis on mitotic processes and ER-Golgi trafficking best describes this group.","confidence":"Medium","size":8,"edges":23,"triangles":31,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0006890","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0035264","count":3}]},{"hash":"1691813468169153260","title":"mRNA processing and stability regulation","description":"The GO terms converge on splicing regulation (via spliceosome), processome assembly, mRNA stabilization and alternative splicing control, as well as miRNA-mediated translational repression and IRES-dependent translation, all reflecting post-transcriptional regulation of gene expression through RNA processing and stability.","confidence":"Medium","size":8,"edges":8,"triangles":3,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":5},{"id":"GO:0048025","count":5},{"id":"GO:0034462","count":4},{"id":"GO:0075522","count":4},{"id":"GO:1901407","count":4}]},{"hash":"763006531924709506","title":"Unknown","description":"Top GO terms span DNA replication, vesicle transport, fatty acid metabolism, carnitine metabolism, nuclear export, NF-kappaB signaling, germ-line development, meristem maintenance, TGF-beta response, and dephosphorylation. The diversity and lack of a common pathway or context across these terms (nucleus, ER-Golgi, metabolism, signaling, and development across organisms) provide no cohesive functional theme to unify the cluster, so a specific label cannot be confidently assigned.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0033539","count":2},{"id":"GO:0009437","count":2},{"id":"GO:0046827","count":2}]},{"hash":"702830738536504267","title":"Post-transcriptional RNA processing and silencing","description":"This cluster is dominated by RNA-centric post-transcriptional regulation: mRNA stability, splicing via the spliceosome, miRNA/ncRNA-mediated silencing, and related aspects of translation initiation and polyadenylation, suggesting a cohesive theme of RNA processing and gene silencing.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":7},{"id":"GO:0010610","count":7},{"id":"GO:0048026","count":7},{"id":"GO:0034462","count":6},{"id":"GO:0075522","count":6}]},{"hash":"1654075753416494474","title":"Steroid hormone biosynthesis and sex differentiation","description":"The top GO terms cluster around steroid hormone production (testosterone and cortisol biosynthesis, androgen metabolism, cholesterol catabolic pathway, omega-hydroxylase P450) and developmental aspects of sexual differentiation (female genitalia development, sex differentiation), suggesting a cohesive group focused on steroid metabolism and sexual development, with a few peripheral metabolic terms likely reflecting broad P450-related activity.","confidence":"High","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030540","count":3},{"id":"GO:0061370","count":3},{"id":"GO:0032094","count":3},{"id":"GO:0008209","count":3},{"id":"GO:0007548","count":2}]},{"hash":"427485544534569634","title":"Plant flowering development and timing","description":"This cluster is dominated by GO terms tied to plant development and flowering regulation, including flower development, short-day photoperiodism, and regulation of the vegetative-to-reproductive transition, suggesting a cohesive theme around flowering control in plants. Some terms (eating behavior, sperm capacitation) are unrelated and likely represent noise, but the recurring plant-specific terms indicate the cluster centers on flowering/development in plants.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009908","count":1},{"id":"GO:0042755","count":1},{"id":"GO:0009910","count":1},{"id":"GO:0048510","count":1},{"id":"GO:0048240","count":1}]},{"hash":"16288359819359686","title":"mRNA processing and splicing regulation","description":"This cluster is dominated by GO terms tied to mRNA fate and processing, including regulation of mRNA stability, mRNA stabilization, alternative splicing via the spliceosome, and polyadenylation, with connections to translation control (miRNA silencing, IRES-dependent initiation). These collectively point to a group of proteins involved in RNA processing and post-transcriptional regulation.","confidence":"High","size":8,"edges":21,"triangles":35,"max_degree":6,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":6},{"id":"GO:0006378","count":5},{"id":"GO:0034462","count":4},{"id":"GO:0075522","count":4},{"id":"GO:1901407","count":4}]},{"hash":"21585877863574317","title":"Chromatin organization and nucleosome assembly","description":"This cluster is dominated by GO terms tied to chromatin structure and nucleosome dynamics\u2014nucleosome assembly, heterochromatin organization, chromatin localization to the nucleus, and histone modifications\u2014indicating proteins involved in chromatin packaging and regulation. A few terms reference ribosome assembly/translation, but they are minor and do not define the cluster\u2019s core function. Therefore, the label reflects the primary theme of chromatin organization and nucleosome regulation.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006334","count":4},{"id":"GO:0080182","count":4},{"id":"GO:0016584","count":4},{"id":"GO:0097298","count":4},{"id":"GO:0071169","count":4}]},{"hash":"684628231883473482","title":"Cross-tissue Development and Differentiation Signaling","description":"The top terms show a mix of developmental processes across tissues (leg patterning, mammary gland and neural cell differentiation) and signaling pathways (JAK-STAT, nitric oxide biosynthesis), suggesting a broad role in developmental signaling and cell fate decisions rather than a single tissue-specific function.","confidence":"Medium","size":8,"edges":12,"triangles":5,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:2000010","count":1},{"id":"GO:0007479","count":1},{"id":"GO:2000252","count":1},{"id":"GO:2000366","count":1},{"id":"GO:0045429","count":1}]},{"hash":"876540697949088978","title":"Neurodevelopment and Glutamatergic Synapse Regulation","description":"The GO terms cluster around neural development and glutamatergic signaling/synapse regulation (ionotropic glutamate receptor pathway, nervous system development, regulation of synapse structure/activity, axon guidance), suggesting a neural development/synaptic function theme. Some placental branching morphogenesis terms appear but do not define the core function of the cluster.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":1},{"id":"GO:0051563","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0060672","count":1}]},{"hash":"2004243584555682121","title":"Auditory Neural Signaling and Paranodal Junctions","description":"The cluster centers on neural signaling related to hearing, highlighted by terms for sensory perception of sound and chemical synaptic transmission, with paranodal junction maintenance reinforcing a role in specialized axon\u2013glial junctions. Although there are a few immune/barrier-related terms in the mix, the dominant pattern points to auditory neural communication and maintenance of neural junctions.","confidence":"Medium","size":8,"edges":12,"triangles":6,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":5},{"id":"GO:0046328","count":5},{"id":"GO:0090557","count":4},{"id":"GO:0007268","count":4},{"id":"GO:0008285","count":4}]},{"hash":"1816894775629150609","title":"Unknown","description":"The top GO terms cover a wide and diverse set of processes (proteolysis and glycosaminoglycan/amino acid catabolism) alongside unrelated items like antibiotic response, zona pellucida penetration, and splicing regulation, indicating no coherent single function tying these proteins together. Confidence: None","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0030214","count":2},{"id":"GO:0030207","count":2},{"id":"GO:0007341","count":2}]},{"hash":"1588588045495911363","title":"Multi-lineage differentiation regulators","description":"This cluster's top GO terms cover differentiation across multiple lineages, including skeletal muscle development and somitogenesis, myoblast fate, as well as neural and glial differentiation (GABAergic interneurons, astrocytes, oligodendrocytes) and cardiac neural crest\u2013related morphogenesis. Some terms also touch on regulation of differentiation (e.g., osteoblast differentiation, androgen signaling). Together, these suggest a set of proteins that broadly regulate lineage specification in muscle and neural/glial lineages, with cardiac development connections, supporting a label of multi-lineage differentiation regulators.","confidence":"High","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0060766","count":7},{"id":"GO:0045668","count":7},{"id":"GO:0048743","count":4},{"id":"GO:0021892","count":4},{"id":"GO:0048711","count":4}]},{"hash":"805496688729047502","title":"Apoptosis and Angiogenesis Signaling","description":"The cluster centers on apoptotic processes (apoptotic process, recognition of apoptotic cell) with supporting membrane remodeling and cell\u2013cell signaling terms (aminophospholipid transport, ectodomain proteolysis, general signaling), plus vascular-related terms (angiogenesis and angiotensin maturation/regulation). This suggests proteins involved in programmed cell death coupled with vascular signaling/remodeling; the name captures these core themes without overreaching. Medium","confidence":"","size":8,"edges":14,"triangles":9,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0043654","count":3},{"id":"GO:0015917","count":3},{"id":"GO:0007267","count":1},{"id":"GO:0003081","count":1}]},{"hash":"912551294427559633","title":"ER protein folding and redox stress response","description":"The cluster shows strong enrichment for ER-associated protein folding, ER stress response, and redox/calcium homeostasis processes (protein folding in ER, response to ER stress, cell redox homeostasis, cellular response to oxidative stress, protein deglutathionylation, retention in ER lumen). These together point to ER quality control and unfolded protein response\u2013type regulation, with redox balance as a central feature. Some transcription-related and viral process terms appear but do not define the core theme. ","confidence":"Medium","size":8,"edges":22,"triangles":25,"max_degree":7,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045454","count":7},{"id":"GO:0034975","count":7},{"id":"GO:1903026","count":5},{"id":"GO:0018401","count":5},{"id":"GO:0034599","count":5}]},{"hash":"2274246642758583835","title":"Cardiac development and gene expression","description":"The cluster\u2019s top GO terms span core gene expression processes (translation and transcription elongation/termination) and cardiac development (atrioventricular canal development; ventricular trabecula myocardium morphogenesis), with some calcium signaling relevance. This suggests proteins involved in heart development that are tied to gene expression machinery, hence the label linking cardiac morphogenesis with transcription/translation processes.","confidence":"Medium","size":8,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0036302","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0010880","count":1},{"id":"GO:0045038","count":1}]},{"hash":"459186573123352484","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0060258","count":3},{"id":"GO:0010825","count":3},{"id":"GO:0070935","count":3}]},{"hash":"2169855152187381235","title":"Unknown","description":"The listed GO terms are highly diverse and include several obsolete terms (e.g., ubiquitin-dependent ERAD pathway, DNA strand renaturation, inheritance of oxidatively modified proteins) as well as unrelated processes like gas vesicle organization. With only 8 proteins and no shared, cohesive pathway evident among the top terms (ERAD, microtubule severing, Golgi retention, DNA repair, cell division, rRNA decay), there isn\u2019t a clear common function to label the cluster. This suggests annotation noise or mixed roles rather than a single functional module.","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0051013","count":1},{"id":"GO:0000733","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0045053","count":1}]},{"hash":"729529358290356266","title":"Retroviral entry and proviral latency","description":"This cluster centers on steps of a retroviral life cycle: entry into the host cell and nucleus, reverse transcription (RNA-templated DNA synthesis), integration of viral DNA into the host genome, and establishment of proviral latency. Additional related terms include DNA recombination and replication and host pathways like apoptosis activation and RNA interference regulation that can be influenced by viruses or symbionts.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2}]},{"hash":"272903230114178076","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006006","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0000435","count":3},{"id":"GO:2000114","count":3},{"id":"GO:0006695","count":3}]},{"hash":"13229064010309567","title":"Steroid and lipid mediator biosynthesis","description":"Based on the dominant GO terms\u2014prostaglandin biosynthesis, cortisol biosynthesis, omega-hydroxylase P450 pathway, and cholesterol catabolic process\u2014the proteins appear to participate in lipid-derived hormone and mediator production and metabolism. Additional terms for redox homeostasis and oxidant detoxification suggest coordinated oxidative processing during lipid metabolism. Some annotations such as response to food or EGFR stimulus are more general, but do not change the central lipid/hormone theme.","confidence":"Medium","size":8,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0071364","count":2}]},{"hash":"1374544953903195169","title":"TGF-\u03b2/Nodal developmental signaling","description":"The proteins show enrichment for TGF-\u03b2 receptor signaling and nodal signaling, with SMAD-related assembly and endoderm/nephrogenic mesenchyme morphogenesis terms, plus related developmental processes like cartilage development and broader regulatory signals (IL-6, miRNA transcription). This suggests a cohesive theme around embryonic development signaling networks dominated by TGF-\u03b2/Nodal pathways.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030511","count":2},{"id":"GO:0033686","count":1},{"id":"GO:0072134","count":1},{"id":"GO:0070102","count":1},{"id":"GO:1902895","count":1}]},{"hash":"1768187341814315729","title":"Cardiac Muscle Contraction and Sarcomere Organization","description":"The top terms point strongly to cardiac muscle function, with direct mentions of cardiac muscle contraction and sarcomere organization (and its positive regulation). There is also regulation of heart rate by epinephrine and vascular smooth muscle cell activity, suggesting related cardiovascular mechanisms. A few terms relate to apoptosis and lipid transport, but they are less central to the cluster's main theme. Thus the label Cardiac Muscle Contraction and Sarcomere Organization captures the core function represented by the cluster.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904753","count":1},{"id":"GO:0034609","count":1},{"id":"GO:0003065","count":1},{"id":"GO:1904706","count":1},{"id":"GO:0045214","count":1}]},{"hash":"555366794531074800","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034414","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0030420","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0017001","count":1}]},{"hash":"650452689706340040","title":"ER homeostasis and secretory trafficking","description":"The cluster is dominated by ER-related processes: protein localization to the endoplasmic reticulum, COPII-coated vesicle budding, and the ER unfolded protein response, all pointing to ER function in protein folding and trafficking, supported by calcium homeostasis. A few viral-host interaction terms are present but do not define the core theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0044828","count":1},{"id":"GO:0060304","count":1},{"id":"GO:0090114","count":1},{"id":"GO:0070972","count":1}]},{"hash":"2251372370050687906","title":"Cilium/axoneme assembly and tubulin modification","description":"The terms are dominated by microtubule-based ciliary/flagellar functions: axoneme assembly, movement of cilia and sperm flagella, and tubulin post-translational modifications (polyglycylation, polyglutamylation). This points to a cohesive role in ciliogenesis and motility, with microtubule dynamics impacting axon extension and related neuron axon organization.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051013","count":1},{"id":"GO:0030516","count":1},{"id":"GO:0003353","count":1},{"id":"GO:0003351","count":1},{"id":"GO:0018094","count":1}]},{"hash":"2039723883385251542","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044829","count":1},{"id":"GO:0045347","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0010587","count":1}]},{"hash":"1292645532030037214","title":"Zinc Ion Homeostasis and Transport","description":"Based on GO terms such as detoxification of zinc ion, sequestration of zinc ion, zinc ion transmembrane transport, and intracellular zinc ion homeostasis, the cluster appears to group proteins involved in managing zinc levels and moving zinc across membranes. The presence of cadmium and iron related terms suggests some overlap with broader metal ion homeostasis, but zinc-related processes dominate the signal. Therefore, the name reflects the primary function represented by the cluster.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0010312","count":2},{"id":"GO:0032119","count":2},{"id":"GO:0071577","count":2},{"id":"GO:0098849","count":2},{"id":"GO:0006877","count":2}]},{"hash":"95433162850160123","title":"Muscle calcium signaling and contraction regulation","description":"This cluster features several GO terms tied to calcium handling in muscle cells, including regulation of calcium release from the sarcoplasmic reticulum and calcium ion concentration in mitochondria, as well as aspects of cardiac electrical conduction and muscle differentiation. The common thread appears to be calcium-dependent signaling that governs muscle contraction and cardiac function, with supporting cytoskeletal (actin) interactions and some development-related terms that may reflect broader tissue roles.","confidence":"Medium","size":7,"edges":6,"triangles":1,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051764","count":3},{"id":"GO:0051562","count":3},{"id":"GO:0032516","count":3},{"id":"GO:0010880","count":3},{"id":"GO:1901844","count":3}]},{"hash":"453444516901323047","title":"Unknown","description":"The top GO terms are scattered across neural signaling (dopamine receptor signaling, cAMP/PKA regulation, octopamine signaling) and unrelated processes (dendritic cell chemotaxis, midgut development, urine volume), with no shared function or interaction pattern (edges/triangles are zero). This lack of a coherent theme makes a single representative function unlikely.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1},{"id":"GO:0031649","count":1},{"id":"GO:0002032","count":1}]},{"hash":"1356026113365611054","title":"ER Stress/UPR and COPII Vesicle Trafficking","description":"This cluster centers on endoplasmic reticulum processes: ER localization, COPII vesicle formation, and the unfolded protein response, consistent with ER-related protein trafficking and stress responses. The presence of host-virus interaction terms is likely ancillary, and the core signals point to ER-associated protein processing and the secretory pathway.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0044828","count":1},{"id":"GO:0060304","count":1},{"id":"GO:0090114","count":1},{"id":"GO:0070972","count":1},{"id":"GO:0030968","count":1}]},{"hash":"1830212669213166346","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006695","count":6},{"id":"GO:0008542","count":6},{"id":"GO:0060258","count":5},{"id":"GO:0010825","count":5},{"id":"GO:0070935","count":5}]},{"hash":"2144393975610616029","title":"Cardiac and muscle development","description":"The top GO terms are dominated by cardiac muscle and general muscle development, including cardiac muscle cell/tissue development, muscle cell development, muscle organ development, and heart contraction, pointing to proteins involved in muscle formation and cardiac function. A few terms like face morphogenesis and osteoclast fusion appear but are less central to this cluster\u2019s main theme. ","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2},{"id":"GO:0048747","count":1},{"id":"GO:0055013","count":1},{"id":"GO:0048738","count":1},{"id":"GO:0007517","count":1}]},{"hash":"247872123326648407","title":"Embryonic Development with Metabolism","description":"The top GO terms cluster around embryonic development (neural crest development, forelimb morphogenesis, ureter maturation, nucleus accumbens development), indicating a developmental/organogenesis theme. Several metabolic or nutrient-signaling terms are present (retinal metabolism, catabolic processes, response to nutrient/cAMP), but they seem secondary to the developmental signal, suggesting a focus on embryonic development with a metabolic context.","confidence":"Medium","size":7,"edges":18,"triangles":23,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":7},{"id":"GO:0019545","count":7},{"id":"GO:0021768","count":7},{"id":"GO:0009447","count":7},{"id":"GO:0006068","count":7}]},{"hash":"1644037010390521904","title":"Unknown","description":"No GO terms are provided for this cluster, so I cannot identify a shared function. The network is fully connected (21 edges among 7 proteins, 35 triangles), indicating strong connectivity, but without GO annotations the cluster's common function cannot be inferred.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[]},{"hash":"2300234527271638979","title":"Developmental ECM Remodeling and Signaling","description":"This cluster's GO terms cluster around collagen-rich extracellular matrix remodeling and developmental processes (endochondral ossification, collagen fibril organization, collagen-activated tyrosine kinase receptor signaling, camera-type eye morphogenesis), supporting a theme of ECM-mediated development. Some terms (complement activation, voltage-gated sodium channel clustering) are less central and may reflect broader or incidental associations. Overall, the core pattern points to developmental ECM remodeling and signaling, hence the label.","confidence":"Medium","size":7,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":1},{"id":"GO:0033034","count":1},{"id":"GO:2000534","count":1},{"id":"GO:0038063","count":1},{"id":"GO:0001867","count":1}]},{"hash":"28342551411182337","title":"Unknown","description":"No top GO terms are provided, so there is no clear shared function to tie these 7 proteins together. Without functional signals, a single coherent label cannot be inferred; the cluster is best described as Unknown.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[]},{"hash":"1617631157684783120","title":"Embryonic brain-eye-limb morphogenesis","description":"The cluster centers on embryonic morphogenesis across brain, eye, and limb tissues, including forebrain and limb patterning, eye development, and neural differentiation such as GABAergic interneurons and amacrine cells. Cartilage development and regulation of vitamin A metabolism point to retinoic acid signaling as a unifying developmental regulator. Overall, these terms suggest a cohesive theme of RA-influenced embryonic morphogenesis in multiple organ systems.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051216","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0048048","count":2},{"id":"GO:0048853","count":2},{"id":"GO:0007479","count":2}]},{"hash":"443488657786117049","title":"Embryonic neural and limb morphogenesis","description":"The proteins cluster around embryonic morphogenesis of neural and sensory structures (forebrain, cerebral cortex interneurons, eye/retina) and limb patterning, with vitamin A (retinoic acid) regulation as an associated motif; one immunoglobulin production term may be incidental noise.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048048","count":1},{"id":"GO:0048853","count":1},{"id":"GO:0007479","count":1},{"id":"GO:0035115","count":1},{"id":"GO:0021892","count":1}]},{"hash":"357399364084909028","title":"Embryonic organ and epithelial morphogenesis","description":"This cluster centers on developmental morphogenesis across multiple organs and epithelial/glandular tissues, including embryonic eye morphogenesis, hindlimb morphogenesis, mammary gland development, prostate gland branching, and cartilage growth, with a note of regulatory control such as negative regulation of epithelial proliferation. The mix of organ-specific morphogenesis terms and epithelial development supports a cohesive theme of embryonic tissue formation and epithelial differentiation. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0048048","count":4},{"id":"GO:0050680","count":4},{"id":"GO:0051866","count":4},{"id":"GO:1902714","count":4},{"id":"GO:0035116","count":4}]},{"hash":"296246291751017460","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":15,"triangles":20,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":6},{"id":"GO:0048026","count":6},{"id":"GO:0072715","count":4},{"id":"GO:0000472","count":4},{"id":"GO:0006301","count":4}]},{"hash":"753543263892719334","title":"Neuronal development and synapse regulation","description":"This cluster\u2019s top GO terms are dominated by nervous system development, ionotropic glutamate receptor signaling, and regulation of synapse structure or activity, suggesting a neural development/synaptic function theme. Some terms (placental branching, amyloid fibril formation) are less central, but the predominant pattern supports the label. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":1},{"id":"GO:0051563","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0060672","count":1}]},{"hash":"1395095161218107641","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0030433","count":2},{"id":"GO:0042866","count":2},{"id":"GO:0009436","count":2},{"id":"GO:0006458","count":1}]},{"hash":"2073520255956955231","title":"Developmental signaling and cell migration","description":"This cluster centers on signaling pathways (PI3K/AKT, Roundabout) and developmental processes (heart and corpus callosum development) with regulation of cell proliferation and migration, suggesting a cohesive theme of signaling-driven development and cell movement. Some outlier terms (like chitin catabolic process) are less connected but do not dominate the set.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043491","count":6},{"id":"GO:0001779","count":6},{"id":"GO:0022038","count":5},{"id":"GO:0006032","count":5},{"id":"GO:0035385","count":5}]},{"hash":"196987746557383472","title":"Mitotic cell division machinery","description":"The cluster is dominated by core mitosis-related terms: cell division, mitotic cell cycle, and regulation of spindle microtubule-kinetochore attachments, with supporting links to actin cable assembly and protein complex formation\u2014consistent with mitotic apparatus and cytoskeletal organization. A few neuron- or development-associated terms appear but are less representative of the primary shared function. ","confidence":"High","size":7,"edges":9,"triangles":3,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0051586","count":1}]},{"hash":"2200276336864927058","title":"Unknown","description":"The top GO terms span immune signaling, RNA decay, development in both animal kidney and plant physiologies, and random processes like phototropism, with no clear shared function tying the seven proteins together. The lack of edges and the presence of an obsolete term further suggest the annotations are noisy, offering no cohesive biological theme to name the cluster confidently.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":1},{"id":"GO:0000184","count":1},{"id":"GO:2001200","count":1},{"id":"GO:0045497","count":1},{"id":"GO:0031397","count":1}]},{"hash":"2171671820887248104","title":"Mitochondrial quality control and ER stress signaling","description":"The cluster centers on organelle maintenance: mitophagy, positive regulation of mitochondrial fusion, and regulation of ER stress\u2013induced apoptotic signaling, plus supporting processes like tail-anchored protein insertion into the ER and protein sumoylation that modulate stress responses and membrane protein handling. A few terms related to development or immune signaling appear peripheral, but the dominant theme ties to mitochondrial-ER homeostasis and quality control.","confidence":"Medium","size":7,"edges":17,"triangles":21,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":6},{"id":"GO:1901340","count":5},{"id":"GO:0071816","count":5},{"id":"GO:0034140","count":5},{"id":"GO:0000423","count":5}]},{"hash":"885721156014987699","title":"Unknown","description":"The GO terms cover a broad mix of processes (calcium ion import, mitotic cell cycle, chromosome separation), developmental topics (forebrain and placenta development), metabolism (glucose metabolic process), and even behavioral/neurotransmitter responses (response to cocaine) and chemotaxis. This lack of a single cohesive biological theme makes it unclear what specific function unifies this cluster, so a neutral label is appropriate.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070509","count":2},{"id":"GO:0051304","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0045793","count":2},{"id":"GO:0033160","count":2}]},{"hash":"596000052191491455","title":"Secretory granule processing and endocrine secretion","description":"Most terms point to secretory pathways and processing of peptide hormones/proteins: dense core granule transport, islet amyloid polypeptide processing, acrosome reaction, and protein autoprocessing suggest regulated maturation and release. LDL receptor\u2013mediated endocytosis and fatty/lipid receptor catabolism indicate trafficking tied to secretory activity, while glycosylation and left-right symmetry terms are more peripheral. Overall, the cluster seems to center on secretory/granule processing and regulated secretion in endocrine and reproductive contexts.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006486","count":3},{"id":"GO:1905601","count":1},{"id":"GO:0016540","count":1},{"id":"GO:0007340","count":1},{"id":"GO:0032911","count":1}]},{"hash":"947687786601989458","title":"Lipid metabolism and signaling","description":"Several top GO terms cluster around metabolism and signaling of lipid-derived molecules: retinal/retinol metabolism (lipid-soluble vitamin pathways), cholesterol catabolic processes, and regulation of testosterone biosynthesis (steroid metabolism); plus signaling lipids such as prostaglandin D stimulus and jasmonic acid stimulus. While there are mentions of stress and reproductive terms, the dominant theme is lipid-based metabolism and lipid-mediated signaling across systems, which provides a coherent, high-level function for the cluster.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":7},{"id":"GO:0042572","count":7},{"id":"GO:0009414","count":4},{"id":"GO:0060135","count":4},{"id":"GO:0006061","count":4}]},{"hash":"1113599350234574239","title":"Stem Cell Development and Epigenetic Regulation","description":"This cluster centers on developmental processes (blastocyst and mammary gland differentiation), stem cell proliferation, and regulation of gene expression through epigenetic mechanisms (CpG methylation and miRNA transcription), with supporting roles in nuclear organization (PML bodies) and growth signaling (GM-CSF response).","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001824","count":3},{"id":"GO:0097011","count":3},{"id":"GO:0030578","count":2},{"id":"GO:0060033","count":2},{"id":"GO:0044027","count":2}]},{"hash":"1729775195440228756","title":"Unknown","description":"The top GO terms are spread across developmental processes (face morphogenesis, biomineral tissue development) and immune/coagulation functions (complement activation pathways, Factor XII activation, fibrinolysis, defense against fungi), with no dominant shared function, making a single coherent label unlikely.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0071333","count":1},{"id":"GO:0003050","count":1},{"id":"GO:0031214","count":1},{"id":"GO:0006958","count":1}]},{"hash":"64051051933804741","title":"Cardiac fatty acid oxidation and heart development","description":"This cluster is dominated by GO terms related to lipid metabolism and fatty acid oxidation (medium-chain fatty acid catabolic process, beta-oxidation using acyl-CoA dehydrogenase, fatty-acyl-CoA biosynthesis, carnitine biosynthesis), plus cardiac-specific terms (cardiac muscle cell differentiation, heart development). The convergence of energy metabolism in lipids with heart development suggests a coherent theme of cardiac energy metabolism and maturation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051793","count":1},{"id":"GO:0033539","count":1},{"id":"GO:0005978","count":1},{"id":"GO:0009409","count":1},{"id":"GO:0055007","count":1}]},{"hash":"1660643148692286282","title":"Developmental signaling and ECM remodeling","description":"This cluster groups proteins linked to tissue remodeling and developmental signaling, including epithelial morphogenesis (lung tubule branching) and regulation of BMP signaling, along with extracellular matrix disassembly and proteolysis, and related remodeling processes seen in bone and reproductive tissue (decidualization). The shared theme is regulation of developmentally important pathways coupled with remodeling of the extracellular matrix, rather than a single isolated pathway.","confidence":"Medium","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0030514","count":2},{"id":"GO:0050790","count":1},{"id":"GO:0060441","count":1},{"id":"GO:0001913","count":1},{"id":"GO:0034769","count":1}]},{"hash":"2007093612525831646","title":"Unknown","description":"The GO terms are highly diverse with little overlap (cell division, ubiquitination, meiotic regulation, proliferation, development, signaling, mRNA transport, etc.), and there are no edges or coherent shared pathways. This lack of a unifying function makes it inappropriate to assign a single, representative label.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0051441","count":1},{"id":"GO:0008284","count":1}]},{"hash":"351044157015163640","title":"Lectin- and Fc receptor\u2013mediated innate immunity","description":"GO terms in this cluster point to innate immune recognition and activation driven by lectin and Fc receptors, including basophil activation, lectin pathway complement activation, C-type lectin receptor signaling, Fc-gamma receptor signaling, and phagocytosis. This suggests a cohesive module of antibody- and lectin-mediated immune responses and microbe recognition, despite a couple of outlier terms related to development. Confidence: Medium","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":7},{"id":"GO:0045575","count":5},{"id":"GO:0001867","count":5},{"id":"GO:0038094","count":5},{"id":"GO:0090403","count":5}]},{"hash":"1204277317690003922","title":"ECM Remodeling and Tissue Morphogenesis","description":"This cluster centers on processes related to extracellular matrix remodeling and tissue morphogenesis, including basement membrane disassembly, epithelial tube branching in lung development, bone resorption, and decidualization. While some terms are broad regulatory signals (regulation of catalytic activity, Wnt signaling localization, thyroid hormone response), they likely modulate remodeling events across tissues, suggesting a coherent theme of ECM-driven tissue remodeling.","confidence":"Medium","size":7,"edges":11,"triangles":6,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0001913","count":5},{"id":"GO:0034769","count":5},{"id":"GO:0046697","count":5}]},{"hash":"2138405273023645199","title":"Lectin-mediated innate immune activation and phagocytosis","description":"This cluster centers on innate immune recognition and effector responses, with GO terms for basophil activation, lectin pathway complement activation, C-type lectin receptor signaling, Fc-gamma receptor signaling, fungal-origin responses, and phagocytosis, suggesting a coherent theme of lectin- and Fc-receptor\u2013driven immune activation; a few kidney development terms may be incidental noise.","confidence":"Medium","size":7,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045575","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0071226","count":3},{"id":"GO:0038094","count":3},{"id":"GO:0090403","count":3}]},{"hash":"2206341497303773488","title":"Phospholipid Biosynthesis Pathways","description":"Top GO terms indicate multiple phospholipid biosynthesis processes (phosphatidylglycerol, phosphatidylethanolamine, phosphatidylserine) and related lipid signaling, with a few unrelated terms. This suggests the cluster predominantly reflects lipid metabolic pathways involved in membrane phospholipid production and remodeling, despite sparse connectivity among proteins.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070317","count":2},{"id":"GO:0010512","count":1},{"id":"GO:1905711","count":1},{"id":"GO:0006655","count":1},{"id":"GO:0006646","count":1}]},{"hash":"859565401130101329","title":"Unknown","description":"The top terms are N-linked glycosylation and face morphogenesis, which do not point to a single cohesive function for this seven-protein cluster. With no edges or interactions and only scattered, unrelated GO terms, there isn\u2019t a clear shared theme to label, soUnknown.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":1},{"id":"GO:0060325","count":1}]},{"hash":"500198595647899263","title":"Mammary gland development signaling cluster","description":"The terms highlight mammary gland epithelial differentiation and alveolus development, coupled with receptor-mediated signaling (EGF stimulus and JAK-STAT) and nitric oxide biosynthesis, pointing to a theme of mammary development governed by growth-factor signaling. Some terms concern other tissues or processes, so the connection is partial; overall, the cluster is best described as mammary development tied to signaling pathways.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071364","count":2},{"id":"GO:2000010","count":1},{"id":"GO:0007479","count":1},{"id":"GO:2000252","count":1},{"id":"GO:2000366","count":1}]},{"hash":"1042564027460948511","title":"Dopaminergic/Octopaminergic GPCR Signaling","description":"The top GO terms point to GPCR-mediated signaling with dopaminergic and octopaminergic involvement, including dopamine receptor signaling and octopamine/tyramine pathways, plus regulation of cAMP-dependent pathways (PKA). While a few terms touch on immune or developmental processes, the core theme across the terms is neuromodulatory GPCR signaling and its downstream cAMP signaling, suggesting a cohesive functional cluster around dopaminergic/octopaminergic signaling networks.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":1},{"id":"GO:0002407","count":1},{"id":"GO:0002882","count":1},{"id":"GO:0031649","count":1},{"id":"GO:0002032","count":1}]},{"hash":"886044365673430288","title":"Unknown","description":"These proteins have a highly diverse set of GO terms, spanning signaling, physiology, development, metabolism, iron homeostasis, and immune regulation, with no clear shared pathway or interactions evident (edges/triangles = 0). Because there is no coherent functional theme tying the terms together, a generic Unknown label is most appropriate.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071318","count":2},{"id":"GO:0008217","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0055114","count":2},{"id":"GO:1901856","count":1}]},{"hash":"1948335835639759503","title":"Unknown","description":"This cluster contains a mix of immune cell trafficking, cytoskeletal organization, autophagy, and cell cycle-related processes, with no single dominant function tying the proteins together, suggesting no cohesive theme.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050826","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0030242","count":1},{"id":"GO:2000401","count":1},{"id":"GO:0046777","count":1}]},{"hash":"1014620602277484359","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0072715","count":1},{"id":"GO:0000472","count":1},{"id":"GO:0006301","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0017038","count":1}]},{"hash":"262359969114380022","title":"Neuronal excitability and synaptic ion transport","description":"The dominant terms center on neural membrane ion transport (Na+, K+, Cl\u2212), excitatory and inhibitory synaptic activity (excitatory postsynaptic potential, GABA receptor clustering), and regulation of neuron survival, pointing to a cluster of proteins involved in neuronal signaling and membrane excitability. A couple terms (acrosome reaction, nitrite transport) are less representative, but do not override the core neural theme.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0043524","count":2},{"id":"GO:0015707","count":2}]},{"hash":"2254800565241874235","title":"Multi-Substrate Membrane Transport","description":"The cluster centers on diverse membrane transport activities across the plasma membrane, including xenobiotic, sugar (galactose, trehalose, glucose-related), and various ion transport (sodium, phosphate, selenite), along with an osmotic stress response. This suggests a cohesive theme of transporter proteins handling multiple substrates rather than a single specific ligand or pathway.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":1},{"id":"GO:0006817","count":1},{"id":"GO:0015771","count":1},{"id":"GO:0052106","count":1},{"id":"GO:0006970","count":1}]},{"hash":"1094987238976113514","title":"ER trafficking and unfolded protein response","description":"The cluster is characterized by GO terms tied to the endoplasmic reticulum: protein localization to the ER, COPII-coated vesicle budding, and the unfolded protein response. Calcium ion homeostasis further supports an ER-centric role. Some viral-host interaction terms are present but do not define core function; the common theme is ER cargo trafficking and stress response.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0044828","count":1},{"id":"GO:0060304","count":1},{"id":"GO:0090114","count":1},{"id":"GO:0070972","count":1},{"id":"GO:0030968","count":1}]},{"hash":"1310512363207380024","title":"Oocyte Meiotic DSB Repair and Cohesion","description":"This cluster is dominated by terms for double-strand break repair in meiotic recombination, regulation of HR, and female meiosis sister chromatid cohesion, plus ovarian follicle development. The inclusion of DNA damage response terms (X-ray, cisplatin, camptothecin) and xenobiotic response further supports a meiosis-related DNA damage repair role in oocytes.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1990918","count":2},{"id":"GO:0090656","count":1},{"id":"GO:0042493","count":1},{"id":"GO:0001541","count":1},{"id":"GO:0072719","count":1}]},{"hash":"2264610877683850832","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":4},{"id":"GO:0008286","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0060258","count":2},{"id":"GO:0010825","count":2}]},{"hash":"1035644710701124251","title":"Ribosome biogenesis and RNA modification","description":"The top GO terms point to ribosome assembly and RNA processing/modification: assembly of large subunit preribosome, maturation of LSU/SSU rRNA, ribosome biogenesis, cytosolic ribosome assembly, and RNA base/tRNA wobble methylation. These collectively indicate a coherent theme focused on ribosome production and RNA modification required for functional ribosomes and translation.","confidence":"High","size":6,"edges":5,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:1902626","count":2},{"id":"GO:0000463","count":2},{"id":"GO:0006355","count":1},{"id":"GO:0070131","count":1},{"id":"GO:0042254","count":1}]},{"hash":"678323332895306295","title":"Developmental signaling and ECM remodeling","description":"This cluster\u2019s top GO terms cluster around developmental processes (Schwann cell development, heart development, multicellular organism development) and extracellular matrix organization, suggesting roles in tissue patterning and structural remodeling. Additional terms related to neural activity and perception (long-term synaptic potentiation, visual perception) along with cell cycle and apoptotic regulation reflect growth control and cell fate decisions during development. Overall, the theme is developmental progression with ECM and tissue organization, rather than a single narrowly defined function.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0014044","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0030198","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0014850","count":3}]},{"hash":"861429142974209373","title":"Neural development and synaptic connectivity","description":"The cluster is dominated by terms related to neurogenesis, dendrite self-avoidance, trans-synaptic signaling, and cell adhesion, all key to neuronal development and the establishment of synaptic networks. While there are broader developmental terms (nephric duct morphogenesis, urogenital system development), the strongest shared theme is neural development and connectivity. ","confidence":"Medium","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":5},{"id":"GO:0022008","count":5},{"id":"GO:0008284","count":4},{"id":"GO:0030336","count":4},{"id":"GO:0072178","count":4}]},{"hash":"347140239180371586","title":"Actin cytoskeleton remodeling and cell motility","description":"The cluster centers on actin-related processes: cortical patch localization, crosslink formation, polymerization-dependent motility, branching, and podosome assembly, with additional support from COPII-coated vesicle loading, which often involves actin in trafficking. This points to proteins coordinating actin dynamics to drive cell shape changes and movement, with some regulatory inputs.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051666","count":3},{"id":"GO:0090110","count":2},{"id":"GO:0051764","count":2},{"id":"GO:0070667","count":2},{"id":"GO:0032911","count":2}]},{"hash":"201083958233928514","title":"Ubiquitin-Dependent Proteolysis and Necroptosis","description":"Top GO terms point to ubiquitin-centric regulation (ubiquitin-dependent protein catabolic process, ubiquitin recycling, K11-linked deubiquitination) and death signaling (ripoptosome assembly involved in necroptotic process, hydrogen peroxide\u2013mediated programmed cell death). This suggests a coherent theme: ubiquitin-controlled proteostasis linked to necroptotic pathways. A few terms appear as outliers (nuclear cortical migration, obsolete terms), but the dominant signal supports this label.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035522","count":1},{"id":"GO:0006511","count":1},{"id":"GO:1900425","count":1},{"id":"GO:1901300","count":1},{"id":"GO:0010870","count":1}]},{"hash":"832296037960215186","title":"Nuclear mRNA export and transcription regulation","description":"This cluster is dominated by GO terms related to transport of macromolecules into and out of the nucleus (mRNA export, ribosomal subunit export, protein import/export), and transcription/ RNA processing (regulation of transcription by RNA polymerase II, splicing factor import). The presence of kinetochore/centrosome regulation hints at cell cycle coordination with nuclear trafficking. Together these terms point to a theme of nuclear RNA processing and transport rather than cytosolic pathways.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":4},{"id":"GO:0035048","count":4},{"id":"GO:0010824","count":4},{"id":"GO:0034501","count":4},{"id":"GO:0000122","count":4}]},{"hash":"2293301172373194784","title":"Mitotic cell cycle regulation and neural development","description":"The cluster is dominated by mitotic cell cycle terms (G1/S and G2/M transitions, mitotic cell cycle, embryonic cleavage, DNA damage checkpoint regulation) indicating a core role in cell division control. While there are neural-associated terms (nervous system development, axon extension) and a few signaling terms (response to cocaine), these appear secondary to the strong cell cycle theme. Thus the label reflects the primary function with some neural development context.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000082","count":2},{"id":"GO:0045773","count":2},{"id":"GO:0000086","count":2},{"id":"GO:0007399","count":2},{"id":"GO:0000278","count":2}]},{"hash":"793978177973031799","title":"Plant vesicle trafficking and cell division","description":"The top GO terms cluster around intracellular transport (ER to Golgi, Golgi to lysosome, general protein transport) and cell division processes (cell division, mitotic chromosome condensation, synaptonemal complex assembly). The presence of amyloplast organization and negative gravitropism points to plant plastid function and gravity response, reinforcing a plant-specific context. Overall, the proteins appear linked to vesicle trafficking intertwined with division-related events in plant cells, with plastid-associated organization contributing to gravitropic signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0051138","count":1},{"id":"GO:1990019","count":1},{"id":"GO:0009660","count":1}]},{"hash":"1816925931602860241","title":"Face morphogenesis","description":"Based on the prominent GO term face morphogenesis (GO:0060325) appearing in the cluster, these proteins appear to be associated with facial development; despite few connections, the shared functional theme is clear enough to label it accordingly.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":2}]},{"hash":"1022539324779715610","title":"Bacterial energy metabolism and bioluminescence","description":"The cluster centers on bacterial metabolic pathways, including phenylacetate and malonate catabolism, pyruvate fermentation to acetate, and menaquinone biosynthesis, with bioluminescence also represented. These together point to energy production and related biosynthetic processes typical of bacterial metabolism, even though a few terms are plant-specific or obsolete and may reflect annotation noise. ","confidence":"Medium","size":6,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010124","count":5},{"id":"GO:0009234","count":5},{"id":"GO:0019654","count":4},{"id":"GO:0008218","count":4},{"id":"GO:0019427","count":4}]},{"hash":"573413012158435098","title":"Unknown","description":"The six proteins show a highly heterogeneous set of GO terms, spanning transcription, nuclear import, kinase activation, metabolism, retina development, and immune/symbiotic responses, with no single dominant function or coherent shared pathway that ties them together. This lack of a unifying theme makes it inappropriate to assign a specific, representative label.","confidence":"","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0060041","count":1},{"id":"GO:1902593","count":1},{"id":"GO:0071353","count":1},{"id":"GO:0009610","count":1}]},{"hash":"280231206717376508","title":"Unknown","description":"The top GO terms span disparate themes including protein post-translational modifications (neddylation, lipidation, urmylation), RNA modification, autophagy-related pathways (Cvt), defense against fungus, and even development, with no clear single function tying the proteins together. This lack of a cohesive theme suggests the cluster cannot be reliably labeled with a specific shared function. ","confidence":"","size":6,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045116","count":2},{"id":"GO:0002143","count":2},{"id":"GO:0007113","count":2},{"id":"GO:0050832","count":2},{"id":"GO:0018192","count":2}]},{"hash":"1780318329224550969","title":"Diverse Biosynthetic Processes","description":"Most of the terms point to biosynthesis of varied compounds (anthocyanin, sterols/ergosterol, nucleoside- and sugar-derived products, poly-hydroxybutyrate, LPS precursors), suggesting a cluster centered on metabolic synthesis across pathways. A couple of terms (hair follicle development, DNA-templated transcription) seem less connected and may reflect broader cellular context or noise. Overall, a broad biosynthetic theme fits best, with moderate confidence.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009718","count":3},{"id":"GO:0016126","count":2},{"id":"GO:0008204","count":2},{"id":"GO:0019305","count":2},{"id":"GO:0001942","count":2}]},{"hash":"870316691264120301","title":"Mitotic Regulation and Ubiquitin Signaling","description":"In this cluster, the dominant GO terms revolve around mitosis and protein turnover: spindle orientation, cell division, sister chromatid cohesion, and polyubiquitination. While a few terms touch on development or signaling, the core theme is cell-division regulation and ubiquitin-related processes, suggesting a cohesive mitotic module.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000132","count":2},{"id":"GO:0051301","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0000747","count":1},{"id":"GO:0051441","count":1}]},{"hash":"1467330223303418949","title":"Unknown","description":"The GO terms across the six proteins span membrane transport, cell cycle components, RNA processing, and movement/response processes with no clear common function. The lack of network edges and the disparate terms suggest the cluster is not cohesively functionally related, so a reliable, specific label cannot be assigned.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015991","count":1},{"id":"GO:0006814","count":1},{"id":"GO:1901207","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0042493","count":1}]},{"hash":"1412033985715824219","title":"Unknown","description":"The terms are spread across several unrelated processes (cell division, spindle-kinetochore attachment, actin/podosome dynamics, Golgi docking, reticulophagy, epidermis morphogenesis, and various signaling pathways), with no dominant shared function and no interactions among proteins, so there is no coherent cluster theme to name confidently.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0051988","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0048730","count":1}]},{"hash":"1230496257923030668","title":"Glycosylation and carbohydrate biosynthesis","description":"This cluster is dominated by GO terms tied to protein glycosylation (GPI anchor biosynthesis, O-linked glycosylation via mannose and via N-acetyl-galactosamine) and carbohydrate metabolism (galactose, glycogen). These point to a common theme of glycoprotein production and sugar-processing pathways affecting cell surfaces and membranes. Some plant/insect\u2013specific terms related to membrane biogenesis and pollen tube growth appear as peripheral signals of membrane/cell wall processes, which can connect to glycosylation-dependent membrane biology, but the core signal remains glycosylation and carbohydrate metabolism. Confidence in this label is moderate due to the mixture of outlier terms. ","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006506","count":2},{"id":"GO:0045313","count":2},{"id":"GO:0009846","count":2},{"id":"GO:0009860","count":2},{"id":"GO:0009834","count":1}]},{"hash":"2053006875009861223","title":"Tissue remodeling and morphogenesis","description":"These proteins appear linked to processes that reshape tissues and direct development: basement membrane disassembly and bone resorption indicate extracellular matrix remodeling, while epithelial tube branching in lung morphogenesis and decidualization reflect morphogenetic tissue changes. T cell\u2013mediated cytotoxicity and bradykinin catabolic processes suggest inflammatory signaling accompanying remodeling. Some terms are broader (regulation of catalytic activity, thyroid hormone response), but the dominant pattern is tissue remodeling and morphogenesis.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0050790","count":2},{"id":"GO:0060441","count":2},{"id":"GO:0001913","count":2},{"id":"GO:0034769","count":2},{"id":"GO:0046697","count":2}]},{"hash":"1046335002102978656","title":"Cell Adhesion and Angiogenesis with Coagulation","description":"This cluster centers on cell-matrix and cell-cell adhesion and migration relevant to sprouting angiogenesis, as shown by GO terms for cell-matrix adhesion, heterophilic adhesion, and positive regulation of endothelial sprouting. It also includes immune and coagulation pathways (complement activation, classical/lectin pathways, and blood coagulation), which are often linked to vascular development and remodeling. Developmental context terms (embryonic development) and hormonal/growth-related terms provide additional biological backdrop. Overall, the shared theme appears to be adhesion-driven vascular development with concurrent immune/coagulation processes.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007160","count":6},{"id":"GO:0090050","count":5},{"id":"GO:0007157","count":5},{"id":"GO:0001867","count":4},{"id":"GO:0006590","count":4}]},{"hash":"161911923676188540","title":"Developmental Regulation and Epigenetic Modulation","description":"The GO terms point to animal organ development (including thymus morphogenesis) and to histone modification/epigenetic regulation, with additional signals for centrosome cycle and apoptotic pathways, suggesting a cluster of proteins coordinating development with chromatin control and cell-cycle checks.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048513","count":1},{"id":"GO:0043972","count":1},{"id":"GO:0097536","count":1},{"id":"GO:0051569","count":1},{"id":"GO:0061087","count":1}]},{"hash":"2026879323608663089","title":"Unknown","description":"The terms span nucleotide metabolism, chromosome organization, development, cytoskeleton, palmitoylation, vacuole fusion, bacterial antigen biosynthesis, and physiological regulation, with no clear unifying function or interaction pattern, so a cohesive cluster label cannot be inferred.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006193","count":1},{"id":"GO:0009213","count":1},{"id":"GO:0051276","count":1},{"id":"GO:0048733","count":1},{"id":"GO:0042144","count":1}]},{"hash":"1661014767546772386","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0060258","count":4},{"id":"GO:0010825","count":4},{"id":"GO:0070935","count":4},{"id":"GO:0003430","count":4},{"id":"GO:0020021","count":4}]},{"hash":"1696013380939543435","title":"Unknown","description":"This cluster has no edges, no triangles, and no top GO terms to define a shared function, so there is no basis to infer a common theme among the proteins. Without annotations or interactions, a meaningful label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"996803012686025208","title":"Unknown","description":"This cluster shows a mix of reproductive processes (prevention of polyspermy, sperm binding to zona pellucida), developmental events (embryonic axis specification, fin morphogenesis), nematode-specific functions (pharyngeal pumping, cuticle/molting), and unrelated processes (pectin catabolic process, proteolysis), with no single cohesive function tying them together. Edges are absent, and the terms do not converge on a shared biological theme, so a confident, specific label cannot be assigned.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060468","count":3},{"id":"GO:0043050","count":3},{"id":"GO:0048632","count":3},{"id":"GO:2000360","count":3},{"id":"GO:0035124","count":3}]},{"hash":"874951410296470282","title":"Apoptosis and Complement-Mediated Clearance","description":"This cluster is dominated by GO terms related to apoptosis (apoptotic process, recognition of apoptotic cell, regulation of myeloid cell apoptotic process) and to complement activation (classical and lectin pathways), with phospholipid transport consistent with apoptotic membrane changes. While a few terms touch on extracellular matrix remodeling, the strongest shared theme is immune-mediated clearance of apoptotic cells. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":1},{"id":"GO:0043654","count":1},{"id":"GO:0015917","count":1},{"id":"GO:0001958","count":1},{"id":"GO:0033034","count":1}]},{"hash":"1772151017174789498","title":"Apoptosis and neural calcium signaling","description":"This cluster shows strong signals for apoptotic processes and recognition of apoptotic cells, with additional terms for calcium-responsive signaling and brain development, suggesting a theme of apoptosis-related pathways in neural development and calcium-mediated regulation. Some lipid transport and eicosanoid biosynthesis terms appear as ancillary processes related to membrane remodeling and inflammatory signaling during apoptosis.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":2},{"id":"GO:0043654","count":2},{"id":"GO:0015917","count":2},{"id":"GO:0001302","count":1},{"id":"GO:0031914","count":1}]},{"hash":"2183957665894726882","title":"Membrane Transporters (various substrates)","description":"The cluster\u2019s top GO terms are dominated by diverse transmembrane transport activities, covering nitrate/nitrite, sugars/arabinose, vitamins, xenobiotics, sialic acid, and ions (Na+/K+). This points to a general role in transporting various substrates across membranes rather than a single specific pathway. Confidence: High","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015706","count":1}]},{"hash":"1609804647149995984","title":"Ribosome biogenesis and translation","description":"The terms cluster around rRNA maturation (5.8S/ LSU), small-subunit processome assembly, and translation (including IRES-dependent initiation), pointing to a shared role in ribosome assembly and protein synthesis. Some mitochondrial/autophagy and developmental terms appear as noise, but the dominant signal is ribosome biogenesis and translation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001165","count":2},{"id":"GO:0006412","count":1},{"id":"GO:0000463","count":1},{"id":"GO:1903955","count":1},{"id":"GO:1903146","count":1}]},{"hash":"2212386911845883513","title":"RNA Pol II Transcription Machinery","description":"The prominent GO terms are all about RNA polymerase II transcription\u2014preinitiation complex assembly, promoter-initiated transcription, and regulation of Pol II transcription\u2014pointing to a cluster of factors involved in Pol II transcription initiation and control. A few non-core terms like viral process and meiosis-related terms are present but do not override the main theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016032","count":2},{"id":"GO:0051123","count":1},{"id":"GO:0006357","count":1},{"id":"GO:0006367","count":1},{"id":"GO:0006351","count":1}]},{"hash":"1730893158325280674","title":"Unknown","description":"The top GO terms span immune response, ribosome biogenesis/export, cell cycle processes, energy transport, cardiovascular regulation, and host-symbiont interactions, with no single cohesive function linking them. Consequently, there isn't a concise, representative label that can be assigned confidently.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002250","count":2},{"id":"GO:0045793","count":1},{"id":"GO:0042274","count":1},{"id":"GO:0042023","count":1},{"id":"GO:1904669","count":1}]},{"hash":"724384076477706741","title":"Dopaminergic/GABAergic Synaptic Signaling and Sleep Regulation","description":"Dominant GO terms point to neuronal signaling at synapses, including dopaminergic regulation, GABA receptor clustering, excitatory postsynaptic potentials, and action potential modulation, with circadian sleep/wake cycle involvement and sensory processing. A couple terms related to non-neural processes appear as minor outliers, but the overall pattern reflects neural signaling and rhythm regulation.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032226","count":4},{"id":"GO:0007340","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0045188","count":3},{"id":"GO:0097112","count":3}]},{"hash":"658449171099089373","title":"Nucleotide and lipid biosynthesis","description":"The cluster shows multiple GO terms for nucleotide biosynthesis (CDP biosynthetic, AMP salvage, ADP biosynthetic, GTP/ITP metabolism, purine ribonucleotide interconversion) and lipid-related biosynthesis (lipopolysaccharide and glycolipid biosynthetic processes), suggesting a cohesive modular role in producing nucleotides and lipid components for membranes; an outlier term like liver development may be noise.","confidence":"Medium","size":5,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0009103","count":2},{"id":"GO:0009247","count":2},{"id":"GO:0046705","count":1},{"id":"GO:0006270","count":1},{"id":"GO:0044209","count":1}]},{"hash":"1744499128368859293","title":"Unknown","description":"The top GO terms cover markedly different biological themes, including mRNA surveillance, innate mucosal immunity, heart/pericardial development, chromatin organization, keratinocyte differentiation, plasminogen activation, and gametogenesis/fertilization. There is no single dominant process or shared molecular function linking all terms; thus the cluster does not map to a coherent biological theme. Therefore we assign Unknown with None.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070481","count":1},{"id":"GO:0002227","count":1},{"id":"GO:0003344","count":1},{"id":"GO:0031508","count":1},{"id":"GO:0045618","count":1}]},{"hash":"266266895047995130","title":"Developmental morphogenesis and ECM signaling","description":"This cluster is driven by terms related to collagen fibril organization, endochondral ossification, and eye morphogenesis, indicating ECM-mediated developmental processes and signaling. The presence of related kidney development terms and collagen-activated signaling supports a cohesive theme around development and matrix interactions, while some immune or neuronal terms appear less central and may reflect broader annotations.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0001958","count":2},{"id":"GO:0033034","count":2},{"id":"GO:2000534","count":2},{"id":"GO:0038063","count":2},{"id":"GO:0001867","count":2}]},{"hash":"1452144963420759373","title":"Chromatin assembly and histone exchange","description":"The cluster centers on chromatin-related processes, with nucleosome assembly and histone exchange as the dominant themes, suggesting chromatin remodeling activities; a few outlier terms (spliceosome change, lithium response) are less connected to this core function.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043486","count":1},{"id":"GO:0010847","count":1},{"id":"GO:0006334","count":1},{"id":"GO:0000388","count":1},{"id":"GO:0010226","count":1}]},{"hash":"1884960036955583402","title":"Neuronal signaling and synaptic excitability","description":"Based on GO terms such as excitatory postsynaptic potential, GABA receptor clustering, and regulation of action potential, along with sodium and chloride transport and sensory processing, the cluster appears to represent neuronal signaling and ion-channel regulation that shapes synaptic transmission and neural excitability. A few terms (acrosome reaction, chondrocyte morphogenesis) seem off-topic noise relative to the dominant neural theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007340","count":4},{"id":"GO:0060079","count":4},{"id":"GO:0045188","count":4},{"id":"GO:0097112","count":4},{"id":"GO:2001226","count":4}]},{"hash":"682087897343969111","title":"Glycerol Metabolism and Glycolysis Regulation","description":"Most enriched GO terms describe glycerol metabolism and glycolysis (gluconeogenesis, glycerol-3-phosphate shuttle, glycerol-3-phosphate biosynthesis, and positive regulation of glycolytic process), suggesting proteins in this cluster participate in managing glycerol flux and carbohydrate metabolism. A few terms relate to signaling or immune responses (cellular response to cAMP, TNF, systemic acquired resistance), which may reflect cross-talk or broad annotations but do not define the core theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000010","count":1},{"id":"GO:0006094","count":1},{"id":"GO:0006973","count":1},{"id":"GO:0033137","count":1},{"id":"GO:0009627","count":1}]},{"hash":"1712330738782055958","title":"Innate Immune Signaling and NLRP3 Regulation","description":"The top GO terms cluster around innate immune response and inflammasome activity, especially NLRP3 inflammasome assembly regulation, supported by ubiquitination processes. A few terms about calcium detection and viral material transport appear as tangential noise; overall the dominant signal is innate immunity and inflammasome regulation.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070534","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0005513","count":1},{"id":"GO:0097050","count":1},{"id":"GO:1900226","count":1}]},{"hash":"2232835342327096354","title":"Unknown","description":"There are no GO terms listed for this cluster, and with only 5 proteins and basic network metrics (7 edges, 3 triangles) there is no clear shared function to group by. Without functional terms, I cannot assign a meaningful label beyond Unknown.","confidence":"","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[]},{"hash":"2210534059108788725","title":"RNA quality control and decay","description":"Top GO terms cluster around RNA quality control and decay, including non-stop decay, nonsense-mediated decay, nuclear mRNA surveillance, and nuclear mRNA catabolic processes, with additional signals for tRNA processing and mitochondrial rRNA handling. The ER-to-Golgi transport term is weaker and not central to the main theme of RNA metabolism, suggesting the core function is RNA surveillance/decay.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070651","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0045006","count":1},{"id":"GO:0070481","count":1},{"id":"GO:0071042","count":1}]},{"hash":"1426852606474673331","title":"Retroviral entry, integration, and latency","description":"The top GO terms cluster around DNA recombination, DNA replication, RNA-templated DNA biosynthesis (reverse transcription), DNA integration, and specifically proviral latency and viral entry into the host nucleus, with some symbiont-entry hints. This combination strongly points to retroviral infection steps and latency establishment as the shared function of these proteins.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:0075732","count":2},{"id":"GO:0046718","count":2},{"id":"GO:0039651","count":2},{"id":"GO:0075713","count":2}]},{"hash":"1125969262023294661","title":"Immune Cell Differentiation","description":"This cluster centers on immune lineage development, with GO terms for granulocyte differentiation, hematopoietic stem cell proliferation, and various T cell differentiation processes, suggesting roles in hematopoiesis and immune lineage specification. A few terms relate to translation or neural crest differentiation, but the dominant theme points to immune differentiation functions.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030851","count":1},{"id":"GO:0071425","count":1},{"id":"GO:0033077","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0046638","count":1}]},{"hash":"1724333861195142186","title":"Unknown","description":"The GO terms span immune system processes (V(D)J recombination, IgG isotype switching, cytokine regulation) and developmental processes (gliogenesis, spinal cord development, pancreatic cell differentiation), plus basic cellular processes (vacuolar acidification, proton transport). There isn\u2019t a single coherent function tying all terms together, so a specific label isn\u2019t justifiable.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007035","count":1},{"id":"GO:1902600","count":1},{"id":"GO:0042063","count":1},{"id":"GO:0048302","count":1},{"id":"GO:0021517","count":1}]},{"hash":"2062596173995652679","title":"Cardiac calcium signaling and conduction","description":"This cluster centers on calcium handling and heart electrical activity: regulation of calcium release from the sarcoplasmic reticulum, mitochondrial calcium concentration, and electrical coupling in cardiac conduction, suggesting a cohesive focus on calcium signaling in cardiac cells. Some other terms are broader or less directly related (transcription, actin crosslinking, thyroid metabolism, neural crest development), but they do not outweigh the core theme.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030948","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0051764","count":2},{"id":"GO:0051562","count":2},{"id":"GO:0032516","count":2}]},{"hash":"156394939114294369","title":"Mitochondrial respiration and peroxisome autophagy","description":"The GO terms cluster around energy production and organelle turnover: mitochondrial electron transport and aerobic respiration point to oxidative metabolism, proton transport supports respiratory chains, and peroxisome autophagy links to organelle maintenance. A freezing-response term is present but less central, so the core theme remains energy metabolism with peroxisome turnover.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050826","count":1},{"id":"GO:0006810","count":1},{"id":"GO:0030242","count":1},{"id":"GO:0006122","count":1},{"id":"GO:1902600","count":1}]},{"hash":"1912893551240164711","title":"Unknown","description":"The GO terms show scattered themes (senescence, sterol/selenium metabolism, xenobiotic and stress responses, chlorophyll-related processes, and rRNA modification) with no apparent common function, and there are no edges connecting the proteins. There isn\u2019t a coherent, shared biological role to assign a specific label, so Unknown is appropriate.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090398","count":1},{"id":"GO:0016126","count":1},{"id":"GO:0042220","count":1},{"id":"GO:0046690","count":1},{"id":"GO:0001887","count":1}]},{"hash":"1200857102514977897","title":"Muscle development and myoblast differentiation regulation","description":"The terms point to muscle formation: myotome development and regulation of myoblast differentiation; plus associated transcriptional regulation, which together suggest a muscle development cluster. A single hormone signaling term (estrogen receptor pathway) is present but does not override the muscle theme.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":1},{"id":"GO:0061055","count":1},{"id":"GO:0045661","count":1},{"id":"GO:1901998","count":1},{"id":"GO:0001966","count":1}]},{"hash":"1088655727539881995","title":"LPS-induced nitrosative stress response","description":"This cluster has strong representation for response to lipopolysaccharide and nitrosative stress, plus S-nitrosylation of cysteine residues, pointing to redox signaling and immune-defense roles. The additional metabolic GO terms suggest ancillary detoxification or catabolic processes but do not define a single cohesive metabolic pathway. Overall, the proteins appear linked to inflammatory/redox response to bacterial components rather than a single canonical metabolic function.","confidence":"Medium","size":5,"edges":4,"triangles":1,"max_degree":3,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0032496","count":4},{"id":"GO:0018119","count":3},{"id":"GO:0006116","count":3},{"id":"GO:0051409","count":3},{"id":"GO:0042573","count":3}]},{"hash":"157251414372343314","title":"Steroid and fatty acid biosynthesis","description":"This cluster\u2019s GO terms are strongly centered on lipid metabolism and steroid hormone biosynthesis (fatty acid elongation, mycolic acid and methyl-branched fatty acids, C21-steroid hormone metabolism, testosterone biosynthetic process). Retinal metabolic processes also tie into lipid biology, while a couple of terms (DNA integration, tropane alkaloid biosynthesis) are more peripheral noise. Overall, the common theme is lipid and steroid biosynthesis. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015074","count":2},{"id":"GO:0042574","count":2},{"id":"GO:0071768","count":2},{"id":"GO:1902321","count":2},{"id":"GO:0030324","count":2}]},{"hash":"1425462742998637749","title":"Cytoplasmic translation and tRNA aminoacylation","description":"Most terms center on translation and tRNA charging (phenylalanyl-, lysyl-, methionyl-tRNA aminoacylation), plus cytoplasmic translation and tRNA processing, indicating a protein synthesis machinery theme. A few unrelated terms (blood vessel morphogenesis, cell division) are present but do not dominate the cluster.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006432","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0008033","count":1},{"id":"GO:0006430","count":1},{"id":"GO:0051351","count":1}]},{"hash":"2294321581493685712","title":"Multisystem Signaling Regulation and Development","description":"The terms cluster around regulatory signaling: modulation of phosphorylation, GPCR signaling, and calcium transport, with associations to brain, vascular development, B cell differentiation, and reproductive processes, suggesting a broad, multisystem role in signaling regulation and development rather than a single tissue-specific function.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033135","count":3},{"id":"GO:0006816","count":3},{"id":"GO:0002316","count":3},{"id":"GO:0007420","count":3},{"id":"GO:0003073","count":3}]},{"hash":"1215496841817434513","title":"Mitosis and ubiquitin-mediated regulation","description":"This cluster centers on cell division (mitosis, spindle elongation) and ubiquitin-related processes (K48-linked ubiquitination, polyubiquitination), suggesting a cohesive theme of cell-cycle control via the ubiquitin-proteasome system. Some terms are obsolete histone modification references, but the core signal is mitosis coupled with ubiquitin regulation.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0051569","count":5},{"id":"GO:1902916","count":5},{"id":"GO:1904153","count":5},{"id":"GO:0033128","count":5}]},{"hash":"2082677788380171974","title":"Neuronal development and synaptic signaling","description":"The top GO terms cluster around neural development and synaptic activity, including ephrin receptor signaling, axonogenesis regulation, dendrite morphogenesis, excitatory postsynaptic potentials, and nervous system development, suggesting proteins involved in neural development and synaptic signaling. Some terms relate to signaling and phosphorylation that support synaptic function, while a single plant-specific term may be annotation noise. Overall, the theme is neuronal development and synaptic communication.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0048013","count":3},{"id":"GO:0050771","count":3},{"id":"GO:0045956","count":3},{"id":"GO:0048813","count":3},{"id":"GO:0060079","count":3}]},{"hash":"1064452440987196524","title":"Neuronal development and synaptic signaling","description":"The top GO terms cluster around neuronal development processes and synaptic function: ephrin receptor signaling, regulation of axonogenesis and dendrite morphogenesis, calcium-dependent exocytosis (neurotransmitter release), excitatory postsynaptic potentials, and nervous system development. This combination points to a cohesive theme of neuronal differentiation and synaptic maturation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048013","count":2},{"id":"GO:0050771","count":2},{"id":"GO:0045956","count":2},{"id":"GO:0034198","count":2},{"id":"GO:0048813","count":2}]},{"hash":"1841878772773263070","title":"Vacuolar Proton Transport and Acidification","description":"The top GO terms cluster around vacuolar function: proton transmembrane transport, vacuolar acidification, assembly of the vacuolar H+-ATPase complex, and polyphosphate metabolism within the vacuole, plus vacuolar protein degradation and excretion. This points to a cohesive role in maintaining vacuolar pH and proton motive force via V-ATPase activity, with related turnover and export processes.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043181","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0007035","count":1},{"id":"GO:0015986","count":1},{"id":"GO:0006797","count":1}]},{"hash":"695934305358695245","title":"Cellular stress response with ubiquitination and sumoylation","description":"The cluster shows consistent signals of cellular stress management: DNA damage checkpoint signaling, oxidative/UV-related responses, and translation regulation under stress, accompanied by protein post-translational modifications via ubiquitination and sumoylation. This combination points to a cohesive theme of maintaining proteome integrity under stress.","confidence":"High","size":5,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000077","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0060733","count":1}]},{"hash":"1874027342301174047","title":"Skeletal-muscle development and signaling","description":"This cluster shows GO terms tied to bone formation (intramembranous ossification, chondrocyte differentiation in bone morphogenesis), muscle function (cardiac and striated muscle contraction, regulation of contraction), and shared signaling pathways (Wnt signaling, tachykinin signaling) with adipogenic differentiation. Overall, the terms suggest a musculoskeletal development and signaling theme spanning bone, cartilage, muscle, and related pathways.","confidence":"Medium","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":2},{"id":"GO:0003413","count":1},{"id":"GO:0010519","count":1},{"id":"GO:0061737","count":1},{"id":"GO:0045988","count":1}]},{"hash":"1957370446379178202","title":"Embryonic development and tissue differentiation","description":"Most terms point to developmental biology\u2014gastrulation, multicellular development, gonad and fertilization, and osteoblast differentiation\u2014along with proliferation and actin remodeling. This suggests a cluster labeled Embryonic development and tissue differentiation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008283","count":2},{"id":"GO:0051572","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0030042","count":2},{"id":"GO:0007568","count":2}]},{"hash":"1931353709679533408","title":"Nematode development and cuticle molting","description":"The terms cluster around developmental processes and morphogenesis, notably the molting cycle and cuticle formation (molting cycle, collagen and cuticulin-based cuticle) and embryonic development/morphogenesis (embryonic caudal fin morphogenesis, maternal specification of dorsal/ventral axis). The presence of nematode-specific features (nematode pharyngeal pumping) further supports a nematode-focused developmental theme, though a few terms are more general. Overall, a coherent theme of development and cuticle-associated remodeling emerges, justifying this label.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":4},{"id":"GO:0018996","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0007313","count":4},{"id":"GO:2000360","count":4}]},{"hash":"2237818801757228297","title":"Innate immune activation and inflammation","description":"Top terms cluster around inflammatory and immune processes (inflammatory response, monocyte activation, response to virus) with some ECM remodeling signals (hyaluronan catabolic process) and epithelial remodeling, suggesting a cluster focused on innate immune activation and inflammation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030214","count":2},{"id":"GO:0060272","count":2},{"id":"GO:0010634","count":2},{"id":"GO:0050729","count":2},{"id":"GO:0035810","count":2}]},{"hash":"574203363630734028","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0052889","count":1},{"id":"GO:0016042","count":1},{"id":"GO:2000344","count":1},{"id":"GO:0071333","count":1}]},{"hash":"1003224677771394430","title":"Viral entry and proviral integration","description":"The terms point to steps in a viral lifecycle that involve entering the host cell/nucleus, reverse transcription of RNA to DNA, integration of viral DNA into the host genome, and establishment of latency, with additional signals of DNA replication/recombination and suppression of host RNA interference\u2014collectively suggesting a retroviral-like life cycle. This makes \u201cViral entry and proviral integration\u201d a concise, representative label for the cluster.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1}]},{"hash":"2262955049593061930","title":"Developmental cell division and intracellular trafficking","description":"This cluster includes several cell-division-related terms (cell division, mitotic sister chromatid cohesion, protein polyubiquitination) alongside vesicle transport (ER to Golgi transport) and developmental processes (brain and spinal cord development, male gonad development), with additional signals like glucose-mediated signaling. The shared theme appears to be general developmental cellular biology involving cell cycle activities and intracellular trafficking, rather than a single specific pathway. ","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0051301","count":3},{"id":"GO:0000209","count":3},{"id":"GO:0000747","count":3},{"id":"GO:0008584","count":3},{"id":"GO:0010255","count":3}]},{"hash":"1592793154091234453","title":"Unknown","description":"The terms are highly heterogeneous, spanning enterobacterial antigen biosynthesis and diverse eukaryotic processes such as actin crosslinking, calcium signaling, extracellular protein localization, cardiac conduction, spindle pole body duplication, thyroid hormone metabolism, and neural crest development. There is no clear, single biological theme uniting these terms, so a specific functional label for this cluster cannot be justified beyond Unknown.","confidence":"","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0009246","count":2},{"id":"GO:0051764","count":1},{"id":"GO:0051562","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0010880","count":1}]},{"hash":"1687162005462584350","title":"Host antiviral immune signaling and ubiquitination regulation","description":"This cluster centers on host defense against viruses and immune signaling (defense response to virus, chemokine response, interferon modulation) and includes regulation of protein ubiquitination and degradation, as well as related nuclear import processes. This suggests a cohesive theme of antiviral immune signaling coupled with control of protein turnover and transport.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002230","count":1},{"id":"GO:0061014","count":1},{"id":"GO:1902714","count":1},{"id":"GO:0032435","count":1},{"id":"GO:1900745","count":1}]},{"hash":"362342345676833391","title":"Neural development and sensory signaling","description":"The terms clustered here mainly point to neural and sensory biology: cerebellar molecular layer development, detection of mechanical stimuli involved in touch, and behavioral response to pain, along with potassium ion export and guanylyl cyclase signaling components that influence neuronal signaling. A few terms are more general (proteolysis) or immune-related (regulation of T cell cytokine production), but the dominant pattern supports neural development and sensory processing. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0002724","count":1},{"id":"GO:0034465","count":1},{"id":"GO:0021679","count":1},{"id":"GO:1902303","count":1}]},{"hash":"1556953715270131480","title":"Neural and vascular development","description":"This cluster shows several GO terms tied to developmental processes, especially neural development (dopaminergic neuron axon guidance, cerebral cortex radial glia-guided migration) and vascular development (angiogenesis and its regulation). While a few terms (like maltose transport and electron transport) are less aligned, the strongest common theme is development in neural and vascular contexts, suggesting a cohesive, albeit broad, developmental function for the group.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0002062","count":1},{"id":"GO:0051867","count":1},{"id":"GO:0022900","count":1}]},{"hash":"726119741153561786","title":"Unknown","description":"The GO terms cover a wide range including regulation of muscle growth, molting/cuticle formation, proteolysis, axis specification, reproductive processes, morphogenesis, and neural development across species. There is no single unifying function or pathway that ties these terms together, and there are no edges linking the proteins, suggesting a heterogeneous cluster rather than a coherent module. Therefore, Unknown with None confidence.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":2},{"id":"GO:0018996","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0007313","count":2},{"id":"GO:2000360","count":2}]},{"hash":"574407230213323651","title":"ER-Golgi trafficking and Wnt secretion","description":"This cluster centers on ER\u2013Golgi transport and regulated secretion, as shown by terms like COPI-coated vesicle budding, Golgi ribbon formation, ER retention, and positive regulation of ER exit, plus Wnt protein secretion. The combination suggests a shared role in vesicle trafficking enabling signaling molecule export (e.g., Wnt), with some axis-development or behavioral terms likely reflecting downstream phenotypes rather than a core function. Confidence: Medium.","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0090161","count":1},{"id":"GO:0002121","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0070863","count":1},{"id":"GO:0048042","count":1}]},{"hash":"975053328056286297","title":"Membrane transporters for xenobiotics and ions","description":"The cluster shows strong enrichment for transmembrane transport terms across a range of substrates (xenobiotics, vitamins, phosphate, trehalose, fucose) and ions (Na+, K+), plus osmotic stress response, which together point to membrane transport proteins moving diverse substrates across membranes. The diversity of substrates with a unifying transport function supports labeling as membrane transporters for xenobiotics and ions.","confidence":"High","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":3},{"id":"GO:0071805","count":3},{"id":"GO:0006855","count":3},{"id":"GO:0035461","count":3},{"id":"GO:0006817","count":2}]},{"hash":"1249995002907453506","title":"Vascular inflammation and pain signaling","description":"The proteins cluster around endothelial cell behavior in blood vessels, chemokine production (e.g., CXCL1, CCL5, MIP-1 alpha), and nociceptive/pain responses, suggesting a shared role in vascular inflammatory signaling and pain-related chemokine regulation. While calcium signaling and SA node regulation appear, the dominant theme is endothelial inflammatory signaling linked to pain. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0097497","count":2},{"id":"GO:0098703","count":2},{"id":"GO:1903759","count":2},{"id":"GO:0098907","count":2},{"id":"GO:0050968","count":2}]},{"hash":"1196274299792957127","title":"Unknown","description":"The GO terms are highly heterogeneous (mitochondrial calcium homeostasis and import, phototransduction, chemotaxis, ethylene signaling, meiotic repair, IL-4 response, and phosphorelay signaling) with no edges linking the proteins, indicating no cohesive shared function. Therefore, a meaningful, specific label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051560","count":1},{"id":"GO:0036444","count":1},{"id":"GO:0006935","count":1},{"id":"GO:0009585","count":1},{"id":"GO:0009584","count":1}]},{"hash":"781700861428484904","title":"Nuclear RNA Processing and Quality Control","description":"These proteins cluster around nuclear RNA maturation and decay pathways, including rRNA and tRNA processing, 90S preribosome assembly, and various mRNA surveillance/decay processes, suggesting a shared role in RNA processing and quality control in the nucleus.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0045006","count":1},{"id":"GO:0070481","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0070651","count":1}]},{"hash":"1544915753678476289","title":"Diverse Substrate Transmembrane Transport","description":"The GO terms are all about transmembrane transport of a variety of substrates (nitrate, arabinose, vitamins, ions, sialic acid, xenobiotics), suggesting these proteins function as transporters handling diverse molecules across membranes.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":1},{"id":"GO:0042128","count":1},{"id":"GO:1900754","count":1},{"id":"GO:0035461","count":1},{"id":"GO:0015706","count":1}]},{"hash":"884003644830704168","title":"Transcription Regulation and Nuclear Receptor Signaling","description":"The terms cluster around transcriptional control and signaling through nuclear receptors: RNA polymerase II promoter clearance, host-mediated activation of viral transcription, and regulation of androgen receptor and vitamin D receptor signaling pathways, with N-terminal peptidyl-lysine acetylation pointing to chromatin-related regulation. A couple of outliers (foam cell differentiation, male meiosis I) suggest some noise, but the common thread is regulation of gene expression via transcription machinery and nuclear receptors. Confidence: Medium","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043923","count":1},{"id":"GO:0035948","count":1},{"id":"GO:1900051","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0060765","count":1}]},{"hash":"1793933209445279594","title":"Spliceosome and RNA Processing","description":"This cluster is strongly enriched for RNA maturation and processing functions: maturation of SSU-rRNA, spliceosomal complex and snRNP assembly, mRNA splicing via the spliceosome, tRNA processing, and transcription termination, plus import into the nucleus and P-body assembly. Together these terms point to a cohesive nuclear RNA processing/splicing module.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030490","count":4},{"id":"GO:0009414","count":4},{"id":"GO:0006369","count":4},{"id":"GO:0000245","count":4},{"id":"GO:0000387","count":4}]},{"hash":"1209961403584396350","title":"Mitotic spindle and chromosome condensation","description":"This cluster is driven by GO terms related to mitosis, including spindle assembly and the centrosome cycle, with supporting chromatin and cohesin-related terms such as chromosome condensation and regulation of cohesin loading. Although several terms are obsolete or tangential (e.g., neuron differentiation, vulval development), the dominant theme ties to cell division and chromatin organization.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":1},{"id":"GO:0072553","count":1},{"id":"GO:0060850","count":1},{"id":"GO:0007098","count":1},{"id":"GO:0071923","count":1}]},{"hash":"1431773147545152500","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006146","count":3},{"id":"GO:0043419","count":2},{"id":"GO:0009442","count":2},{"id":"GO:0019700","count":2},{"id":"GO:0007411","count":2}]},{"hash":"97215755007444969","title":"NOD2-NF-kB signaling and ubiquitination","description":"Top terms cluster around innate immune signaling (NOD2 pathway) and NF-kB regulation, with protein ubiquitination as a central process. While a few terms appear unrelated (e.g., certain behavioral and muscle-related terms), the core theme suggests involvement in receptor-mediated inflammatory signaling and its regulation through ubiquitination and related trafficking. ","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0070431","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0032088","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0072660","count":1}]},{"hash":"2125210831565205794","title":"Cerebellar development and Bergmann glia differentiation","description":"This cluster is anchored by cerebellar-specific terms: cerebellar cortex formation and Bergmann glial cell differentiation, pointing to cerebellar neural development. Supporting neural context comes from axon regeneration and DNA-templated transcription, while other terms are broader or peripheral to this theme.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0008285","count":3},{"id":"GO:0021697","count":3},{"id":"GO:0060020","count":3},{"id":"GO:0050852","count":3},{"id":"GO:0048679","count":3}]},{"hash":"1667141978752382546","title":"Carbohydrate metabolism and salvage pathways","description":"The GO terms point to sugar processing, glycolytic steps, and various carbohydrate catabolic processes (e.g., phosphorylation, fructose-6-phosphate\u2013linked glycolysis, tagatose and sulfoquinovose catabolism) along with nucleotide salvage processes (AMP and adenosine). Together, they suggest a cluster centered on carbohydrate metabolism with supporting salvage reactions.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":1},{"id":"GO:0010264","count":1},{"id":"GO:2001059","count":1},{"id":"GO:0044209","count":1},{"id":"GO:0061615","count":1}]},{"hash":"2030484003570288032","title":"Ribosome Rescue and Quality Control","description":"The cluster is dominated by ribosome-related processes: ribosome-associated ubiquitin-dependent protein catabolic process and rescue of stalled cytosolic ribosomes, both core components of ribosome quality control. The apoptosis signaling term suggests a broader stress response that can accompany ribosomal stress, while nitroglycerin metabolism seems incidental. Overall, the primary theme is ribosome rescue/quality control, with a possible secondary stress connection.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990116","count":1},{"id":"GO:0018937","count":1},{"id":"GO:1902167","count":1},{"id":"GO:0072344","count":1}]},{"hash":"1299820205638950612","title":"DNA Damage Repair and Response","description":"The top terms are dominated by DNA repair processes (NER, BER, UV-damage excision) and DNA-damage\u2013triggered apoptotic signaling, indicating a cohesive DNA damage response module; a few terms about mRNA export and helicase regulation may support general genome maintenance, but the core signal is DNA repair and damage signaling.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016973","count":1},{"id":"GO:0032781","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0008630","count":1},{"id":"GO:0000715","count":1}]},{"hash":"2258025276123199979","title":"RNA processing and post-transcriptional regulation","description":"The GO terms cluster around RNA maturation, splicing, polyadenylation, mRNA stability, and various layers of translation control (including miRNA silencing and NMD), all pointing to post-transcriptional RNA regulation rather than transcriptional or metabolic roles. This makes a coherent label focusing on RNA processing and post-transcriptional regulation appropriate for the cluster.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0048255","count":1},{"id":"GO:2000623","count":1}]},{"hash":"1910155666730915373","title":"DNA Replication and Nucleotide Biosynthesis","description":"The GO terms cluster around DNA synthesis and nucleotide metabolism\u2014DNA replication; DNA biosynthetic process; TMP biosynthesis; dGTP and pyrimidine nucleotide salvage. This suggests a coherent role in supplying nucleotides for DNA replication, with a possible ancillary link to mitochondrial nucleotide metabolism.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0009157","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0046092","count":1},{"id":"GO:0006230","count":1}]},{"hash":"726432563951296756","title":"Post-transcriptional RNA processing and regulation","description":"The GO terms cluster around mRNA fate after transcription: mRNA stability and stabilization, regulation of alternative splicing via the spliceosome, mRNA polyadenylation, and RNA silencing pathways (miRNA- and regulatory ncRNA-mediated). There\u2019s also involvement in translation initiation and small-subunit processome assembly, all pointing to post-transcriptional RNA metabolism and control of gene expression at the RNA level.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0010610","count":2},{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0048255","count":1}]},{"hash":"369761355748938189","title":"Glutamatergic signaling and neural development","description":"These terms cluster around ionotropic glutamate receptor signaling, nervous system development, and regulation of synapse structure, plus related axon guidance and synaptic activity ideas. The dominant theme is neural development and glutamatergic synaptic function, with supportive signals from calcium homeostasis and collateral sprouting. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0035235","count":1},{"id":"GO:0051563","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0007399","count":1},{"id":"GO:0060672","count":1}]},{"hash":"1647419296425307252","title":"Mitochondrial Energy Production and Apoptosis","description":"Most top GO terms describe mitochondrial processes: mitochondrial translation, electron transport from ubiquinol to cytochrome c, and proton transmembrane transport, plus nicotinamide nucleotide metabolism and apoptotic process. These converge on energy generation and regulation of cell death in the organelle. A few outlier terms (e.g., nonphotochemical quenching) are less central, but don\u2019t negate the mitochondrial focus.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0010196","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0031087","count":1},{"id":"GO:0046496","count":1},{"id":"GO:0006915","count":1}]},{"hash":"2001456448059064886","title":"Membrane Transporters","description":"This cluster is dominated by transmembrane transport GO terms (xenobiotic, vitamin, potassium, sodium, phosphate, trehalose), indicating a common function as membrane transporter proteins mediating substrate movement across membranes. While some terms vary in substrate, the unifying theme is transport activity across membranes. ","confidence":"High","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":4},{"id":"GO:0071805","count":4},{"id":"GO:0006855","count":4},{"id":"GO:0035461","count":4},{"id":"GO:0006817","count":3}]},{"hash":"1285518176459746106","title":"Vesicle trafficking and secretory pathway","description":"This cluster shows strong representation of endosome-to-lysosome transport, multivesicular body sorting, ESCRT-related viral budding, exosomal secretion regulation, and Golgi retention, all pointing to the intracellular vesicle trafficking and secretory pathway. While there are a few terms related to mitochondria (cristae formation, ATP synthesis), the dominant signal is vesicle transport and secretory regulation, making the proposed label representative. ","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0015986","count":1},{"id":"GO:0042407","count":1},{"id":"GO:0035786","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0045053","count":1}]},{"hash":"2055161551422472275","title":"Mitotic dynamics and Golgi retention under oxidative stress","description":"The cluster highlights mitotic/dynamic microtubule processes (microtubule severing and cell division) along with protein retention in the Golgi and a cellular oxidative stress response, suggesting coordination of cell cycle progression with Golgi trafficking under stress conditions. Some terms are obsolete, but the core themes point to mitotic dynamics and organelle maintenance during stress.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051013","count":2},{"id":"GO:0000733","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0001319","count":2}]},{"hash":"62309459426418292","title":"DNA replication, transcription, and repair","description":"The cluster is centered on nuclear DNA processes\u2014DNA-templated transcription, DNA replication, DNA repair\u2014and cell-cycle-related mitosis and division, suggesting a cohesive set of proteins involved in DNA metabolism and genome maintenance.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:1903715","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0006281","count":3}]},{"hash":"1033974076899277968","title":"Ubiquitin-mediated protein degradation","description":"The cluster\u2019s top GO terms center on ubiquitination (K63-linked and polyubiquitination) and related pathways (autoubiquitination, ERAD), pointing to a shared role in tagging proteins for degradation and quality control, with a few peripheral terms related to broader regulatory processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0090359","count":1},{"id":"GO:0070534","count":1},{"id":"GO:0031943","count":1},{"id":"GO:0071361","count":1}]},{"hash":"479735054333246231","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms related to ribosome biogenesis (ribosome biogenesis, ribosomal subunit biogenesis, ribosomal large subunit export from nucleus) and cytoplasmic translation, with supporting terms for overall protein synthesis. While cell cycle and division-related terms appear (cell cycle, cell division, cell septum assembly), the core signal centers on ribosome assembly and function, suggesting a group of proteins involved in ribosome production and translation during growth/division.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1901001","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000747","count":1},{"id":"GO:1903833","count":1}]},{"hash":"1157320308112377457","title":"Unknown","description":"The top terms mix histone acetylation (nuclear processes) with sarcomere organization and retina/homeostasis, plus other general growth and cell-shape terms. There isn\u2019t a single clear, cohesive biological theme linking these functions, especially with obsolete GO terms, so a single representative label isn\u2019t justifiable.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043982","count":4},{"id":"GO:1904623","count":4},{"id":"GO:0043983","count":4},{"id":"GO:0045214","count":4},{"id":"GO:0009825","count":4}]},{"hash":"1987403324139726942","title":"SREBP-Cholesterol Biosynthesis and Homeostasis","description":"The terms are dominated by lipid metabolism, especially cholesterol, with SREBP signaling (GO:0032933), cholesterol biosynthetic process (GO:0006695), and cholesterol homeostasis (GO:2000189) appearing prominently, along with related sphingolipid metabolism (GO:6665) and regulation of cholesterol biosynthetic processes. A few tissue differentiation terms (e.g., mammary gland) may reflect broader lipid-related roles, but the central theme across the cluster is cholesterol biosynthesis and its regulation via SREBP. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032933","count":2},{"id":"GO:0021522","count":1},{"id":"GO:0006665","count":1},{"id":"GO:0045540","count":1},{"id":"GO:0060644","count":1}]},{"hash":"1969980197316475557","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0009190","count":4},{"id":"GO:0060258","count":3},{"id":"GO:0010825","count":3},{"id":"GO:0070935","count":3},{"id":"GO:0003430","count":3}]},{"hash":"1736312572688779479","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0048542","count":1},{"id":"GO:0000461","count":1},{"id":"GO:0042274","count":1}]},{"hash":"1172922328613318996","title":"Carbohydrate catabolic pathways","description":"This cluster shows a strong tilt toward sugar metabolism, with multiple GO terms for catabolic processes of xylose, gluconate, rhamnose, fucose, and related carbohydrate phosphorylation and glycerol-3-phosphate biosynthesis. A couple of terms (quorum sensing, IL-13 response) are less central, but the prevailing pattern is sugar catabolism. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046835","count":2},{"id":"GO:0042732","count":1},{"id":"GO:0019640","count":1},{"id":"GO:0005998","count":1},{"id":"GO:0019301","count":1}]},{"hash":"237950973636637173","title":"Nuclear transcription and RNA processing","description":"This cluster includes terms for RNA Pol II transcription termination, splicing, mRNA export, and chromatin-related processes (pericentric heterochromatin formation, nucleosome density regulation), plus DNA damage tolerance and ubiquitination, all pointing to nuclear gene expression regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006301","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0000209","count":1},{"id":"GO:0031508","count":1},{"id":"GO:0000390","count":1}]},{"hash":"804031654069747235","title":"Transcription Regulation and Histone Modification","description":"The top GO terms point to control of gene expression via chromatin, especially transcription regulation (GO:0006355) and multiple histone acetylation events (GO:0043982, GO:0043966, GO:0043983, GO:0043981). This suggests a shared function in chromatin-mediated transcription control, with some developmental-context terms (sensory organ precursor fate, imaginal disc fusion) that can be downstream of transcriptional programs. A few terms (actin crosslinking, mitochondrial calcium) are less connected, likely noise. Overall, the cluster centers on gene expression regulation through histone modification.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006355","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0045652","count":2},{"id":"GO:0043966","count":2},{"id":"GO:0043983","count":2}]},{"hash":"1502249100611480784","title":"Spliceosome-Mediated RNA Processing","description":"The strongest signal is mRNA splicing via spliceosome (GO:0000398) with 4 proteins, supported by related RNA processing terms like mRNA transport (GO:0010255). While there are secondary terms tied to cell division and ubiquitination, these appear less central to the cluster\u2019s core theme. Thus the label highlights the dominant RNA processing function, with some cell-cycle context as secondary associations.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":4},{"id":"GO:0051301","count":2},{"id":"GO:0000209","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0051441","count":2}]},{"hash":"1899226713101712586","title":"ECM remodeling and morphogenesis","description":"This cluster centers on tissue remodeling and morphogenesis, with terms like basement membrane disassembly, bone resorption, decidualization, and epithelial tube branching (lung morphogenesis) suggesting ECM dynamics during development. Additional terms point to secretion and extracellular localization (ER\u2013Golgi transport, Wnt localization to extracellular region), reinforcing a theme of remodeling coupled with secretory signaling. Immune or catabolic terms appear less central to the core theme. ","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0050790","count":2},{"id":"GO:0060441","count":2},{"id":"GO:0001913","count":2},{"id":"GO:0034769","count":2}]},{"hash":"2263200644900972718","title":"Unknown","description":"The top GO terms include both antibiotic response/catabolic processes and several insect behavioral and neuromuscular terms, with no clear single functional theme tying all four proteins together. This mixture suggests no coherent, shared function can be assigned to the cluster as a whole.","confidence":"","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0033252","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0030655","count":2},{"id":"GO:0019876","count":2},{"id":"GO:1901045","count":1}]},{"hash":"2265898658128438067","title":"Symbiont-host interaction and bacterial transcriptional regulation","description":"The top GO terms point to host-associated activity, including symbiont-mediated evasion of host immune response and interaction with host via symbiont surface, suggesting a focus on host interaction. Concurrently, terms about nitrogen metabolism and transcriptional regulation (nitrogen starvation, nitrogen catabolite repression, core promoter binding) imply bacterial gene regulation tied to metabolic cues in a symbiotic context. Together, they indicate a cluster centered on host interaction coupled with bacterial transcriptional control, though the mix of terms introduces some noise. ","confidence":"Medium","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":2},{"id":"GO:0006542","count":2},{"id":"GO:0020012","count":2},{"id":"GO:1904797","count":2},{"id":"GO:0006995","count":2}]},{"hash":"941032997475652063","title":"Mitochondrial Transporters and Energy Metabolism","description":"The GO terms point to transport of metabolites across mitochondrial membranes (pyrimidine nucleotides, malate-aspartate shuttle, ATP, thiamine pyrophosphate, heme, CoA) and to regulation of mitochondrial membrane potential, indicating a cohesive theme of mitochondrial transport and energy work. A few terms (IGF response, pregnancy, necroptosis regulation) are broader and unlikely to redefine the main function.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":1},{"id":"GO:0007565","count":1},{"id":"GO:0043490","count":1},{"id":"GO:1990544","count":1},{"id":"GO:0030974","count":1}]},{"hash":"674942745544159765","title":"Unknown","description":"The GO terms span diverse, seemingly unrelated processes (proton and sterol transport, sterol biosynthesis/transport, intermediate filament organization, GTPase regulation, chromatin remodeling, autophagy and proteasome regulation, and plant ABA-related seed dormancy), with no clear shared molecular function or pathway linking the proteins. The small cluster size and lack of a common theme support labeling it Unknown.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1902600","count":1},{"id":"GO:0016126","count":1},{"id":"GO:0045109","count":1},{"id":"GO:0098755","count":1},{"id":"GO:1902902","count":1}]},{"hash":"2088213255865066059","title":"Motor neuron differentiation and NMJ development","description":"The cluster is dominated by GO terms related to motor neuron development and differentiation (spinal cord motor neuron differentiation, neuron fate specification, neuromuscular junction development), indicating a role in motor neuron formation and NMJ formation. Additional translation- and membrane-targeting terms may reflect supporting cellular processes, but the core signal points to neuronal development, especially motor neurons and NMJ formation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000384","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0034599","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0006614","count":1}]},{"hash":"1986152064837926293","title":"Muscle cytoskeleton and sarcomere organization","description":"This cluster is dominated by terms tied to actin organization, sarcomere assembly, focal adhesions, and smooth/skeletal muscle dynamics (e.g., actin crosslink formation, sarcomere organization, focal adhesion assembly, smooth muscle chemotaxis, skeletal muscle atrophy, baroreceptor-related blood pressure regulation). While a couple of terms touch neural signaling or SMAD pathways, the strongest and most frequent themes center on cytoskeletal arrangement and muscle structure, suggesting a cohesive role in muscle cell architecture and contractile apparatus.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0021564","count":1},{"id":"GO:0014732","count":1},{"id":"GO:1903478","count":1},{"id":"GO:0051764","count":1},{"id":"GO:0007182","count":1}]},{"hash":"1343071370175943725","title":"Neuronal development and axon guidance","description":"GO terms show a strong emphasis on neural development and connectivity, including dendritic spine regulation, pyramidal neuron differentiation, and Roundabout signaling (axon guidance), complemented by cell adhesion and planar polarity features that support neural morphogenesis. While some terms relate to broader organ development, the dominant pattern is neural development and guidance cues.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061000","count":2},{"id":"GO:0048378","count":1},{"id":"GO:0035385","count":1},{"id":"GO:0016337","count":1},{"id":"GO:0001736","count":1}]},{"hash":"1433744751951227780","title":"Axon Guidance and Neuronal Adhesion","description":"Based on the predominant GO terms, the proteins are linked to axon pathfinding and neuron\u2013cell adhesion, with semaphorin-plexin signaling, ROBO pathway, and juxtaparanode localization indicating neuronal wiring and contact-mediated interactions. Immune-related terms appear but are less central to the core theme. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":2},{"id":"GO:0007157","count":2},{"id":"GO:1902287","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0048378","count":1}]},{"hash":"785796394234023752","title":"Apoptosis-associated membrane remodeling and clearance","description":"Top terms suggest apoptosis (cell death), clearance of apoptotic cells, and membrane phospholipid handling, with filopodium assembly reflecting actin-driven remodeling. This points to apoptosis-related membrane changes and subsequent phagocytic clearance, rather than a single tight pathway. Confident it fits an apoptosis/membrane-remodeling theme, though limited protein set lowers certainty.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046847","count":1},{"id":"GO:0006915","count":1},{"id":"GO:0043654","count":1},{"id":"GO:0015917","count":1}]},{"hash":"204532668218193534","title":"Unknown","description":"There are no GO terms listed (Top Terms is empty) and the cluster has no edges or triangles, so there is no evident shared function connecting the three proteins. Without a functional signal to guide naming, this cluster is best labeled Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1124418168036790663","title":"Cholesterol Metabolism and Hormone Response","description":"This cluster is dominated by GO terms related to cholesterol biosynthesis, regulation, homeostasis, and cholesterol- and steroid hormone\u2013responsive processes (e.g., regulation of cholesterol biosynthetic process, cholesterol homeostasis, cellular response to steroid hormone stimulus, cellular response to cholesterol). These suggest a cohesive theme around cholesterol metabolism and hormone signaling, with some developmental terms present but not defining the core function. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045540","count":2},{"id":"GO:2000189","count":2},{"id":"GO:0060603","count":2},{"id":"GO:0006695","count":2},{"id":"GO:0072203","count":2}]},{"hash":"793026401024614549","title":"Unknown","description":"There are no GO terms or connections among the proteins (no edges, no triangles, empty top terms), so there is no shared function to assign. Without functional signals, the cluster cannot be confidently labeled.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1546615716258079453","title":"Unknown","description":"The two top GO terms point to distinct biological processes\u2014activation of protein kinase activity and ribosome biogenesis. There isn't a clear shared function or pathway tying these three proteins together, and the small interaction graph (one edge) provides little evidence of a cohesive role. Therefore, I cannot assign a confident, specific label.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0032147","count":1},{"id":"GO:0042254","count":1}]},{"hash":"819927913246909729","title":"Membrane Transporters","description":"These proteins are tied together by a broad set of transmembrane transport activities, including xenobiotic, phosphate, sugar (trehalose, galactose, glucose), sodium, and selenite transport, as well as responses to osmotic stress. The common function is moving diverse substrates across the plasma membrane, suggesting a cluster of membrane transporter proteins or transport-related roles rather than a single substrate pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042908","count":3},{"id":"GO:0006817","count":3},{"id":"GO:0015771","count":3},{"id":"GO:0052106","count":3},{"id":"GO:0006970","count":3}]},{"hash":"1177211399456151522","title":"Unknown","description":"There are no GO terms or connections captured for this cluster (no edges, no terms), so there is no evident shared function to name; the three proteins appear unconnected and lacking a common theme.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1416740462514960031","title":"Mitochondrial Metabolite Transport","description":"The top GO terms are dominated by transmembrane transport into/out of the mitochondrion for diverse metabolites (nucleotides, CoA, thiamine pyrophosphate, heme, ATP) and by related energy functions such as the malate-aspartate shuttle and regulation of membrane potential, indicating a cohesive theme of mitochondrial metabolite exchange and energy metabolism.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1990519","count":1},{"id":"GO:0007565","count":1},{"id":"GO:0043490","count":1},{"id":"GO:1990544","count":1},{"id":"GO:0030974","count":1}]},{"hash":"573687305459653115","title":"Diverse Substrate Membrane Transport","description":"The top GO terms cluster around transmembrane transport of a wide range of substrates\u2014nitrate/nitrite, sugars like arabinose, vitamins, xenobiotics, sodium and potassium ions, sialic acid, and other compounds\u2014indicating a group of membrane transporter proteins with broad substrate specificity.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":2},{"id":"GO:0042128","count":2},{"id":"GO:1900754","count":2},{"id":"GO:0035461","count":2},{"id":"GO:0015706","count":2}]},{"hash":"1969468311863972213","title":"Organ development and morphogenesis","description":"This cluster is dominated by GO terms related to organ development and morphogenesis, notably animal organ development and thymus epithelium morphogenesis, suggesting a developmental/morphogenetic role. Additional terms hint at apoptosis and cell-cycle processes (apoptotic signaling pathway, centrosome cycle), which can accompany developmental programs. Some histone modification terms are listed as obsolete, likely noise, but the primary signal points to developmental organization rather than a single enzymatic activity. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048513","count":1},{"id":"GO:0043972","count":1},{"id":"GO:0097536","count":1},{"id":"GO:0051569","count":1},{"id":"GO:0061087","count":1}]},{"hash":"164250520518910011","title":"Mitochondrial protein import and apoptosis regulation","description":"The proteins cluster around mitochondrial functions\u2014inner membrane protein insertion, mitochondrial protein transport, fission, calcium regulation\u2014and link to intrinsic apoptotic signaling, with additional metabolic stress terms (glucose/flavonoid response) consistent with mitochondrial involvement.","confidence":"High","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0032979","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0071333","count":1},{"id":"GO:0090314","count":1},{"id":"GO:1904579","count":1}]},{"hash":"1768996521536857732","title":"Unknown","description":"There are no GO terms or functional signals tying these proteins together (no edges, no triangles, and no top terms reported). Without a common theme to justify a specific label, the appropriate name is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"6285112944660157","title":"Unknown","description":"There are no GO terms provided for this cluster, and with only 3 proteins and no shared functional annotations, there is no clear common theme to assign a more specific label. Thus the appropriate label is Unknown.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"713862474004903121","title":"Unknown","description":"The GO terms span detoxification, translation, metal ion responses, hormone signaling, DNA damage response, and physiological processes with no single shared function tying all terms together, and there are no interactions suggested by edges; thus no cohesive cluster function can be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070458","count":1},{"id":"GO:0002182","count":1},{"id":"GO:0006749","count":1},{"id":"GO:0042994","count":1},{"id":"GO:0071285","count":1}]},{"hash":"2151809682176935109","title":"RNA processing and translational control","description":"This cluster centers on post-transcriptional gene regulation: RNA processing events (spliceosome-mediated splicing, small-subunit processome) and mRNA stability, together with translational control mechanisms (IRES-dependent initiation, translation reinitiation) and RNA silencing by miRNA and regulatory ncRNAs. The GO terms collectively point to RNA maturation and regulation of gene expression at the mRNA level, spanning splicing, stability, silencing, and initiation. ","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0034462","count":3},{"id":"GO:0075522","count":3},{"id":"GO:1901407","count":3},{"id":"GO:0048255","count":3},{"id":"GO:0035278","count":3}]},{"hash":"1149662224006886850","title":"Unknown","description":"The cluster lacks any shared GO terms, edges, or functional signals to tie the three proteins to a common function, so there is no clear theme to name. Without informative annotations, the appropriate label is Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2071501092466602488","title":"Unknown","description":"The GO terms span RNA processing, multiple signaling pathways (TORC2, Ras, stress-activated kinases), cytoskeletal polarity, synaptic assembly, cell migration, stress granule formation, and neural development, with no single unifying function across the cluster. This heterogeneity suggests there isn\u2019t a coherent, well-defined theme for these proteins in this cluster, so Unknown is the most appropriate label. None","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0000469","count":1},{"id":"GO:0038203","count":1},{"id":"GO:0046580","count":1},{"id":"GO:0030950","count":1}]},{"hash":"956004599083501101","title":"Mitochondrial import and membrane permeability regulation","description":"The strongest signals are mitochondrial-related: protein import into the mitochondrial matrix and regulation of mitochondrial membrane permeability, suggesting a mitochondrial function focus for this cluster. There are also hints of lipid biosynthesis regulation and cell cycle regulation, but these are less central, making the mitochondrial theme the most representative.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030150","count":1},{"id":"GO:0046902","count":1},{"id":"GO:0010867","count":1},{"id":"GO:1903740","count":1},{"id":"GO:2000134","count":1}]},{"hash":"738333129201243525","title":"Unknown","description":"There are no GO terms or interactions among the proteins (edges 0, triangles 0, empty top terms), so no shared function can be inferred. ReCIPE additions do not reveal a common theme here. Therefore, Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1188260636509526832","title":"Unknown","description":"The top GO terms are too heterogeneous, spanning ion transport, hormone signaling, autophagy, cell cycle, podosome/cytoskeletal processes, immune cell migration, lysosomal pH regulation, xenobiotic response, ER-Golgi transport, and sporulation, with no clear shared function or pathway tying the proteins together. Therefore there is no cohesive theme to label a specific function for this cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006817","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0061709","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0071803","count":1}]},{"hash":"276581206848407535","title":"Unknown","description":"The top GO terms include heart development (atrio-ventricular canal, ventricular trabecula morphogenesis) and various transcription-related processes, plus a few unrelated terms (calcium regulation in muscle, chloroplast protein import, DNA methylation). With only 3 proteins and no edges, the terms span disparate functions, so there isn\u2019t a coherent, single function to label the cluster. ","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0036302","count":1},{"id":"GO:0006369","count":1},{"id":"GO:0010880","count":1},{"id":"GO:0045038","count":1},{"id":"GO:0006368","count":1}]},{"hash":"953131451159993911","title":"Vesicle Trafficking and Membrane Dynamics","description":"The Top Terms are dominated by intracellular transport and membrane-related processes: ER-to-Golgi vesicle transport, endosome-to-lysosome transport, lysosomal membrane organization, and calcium-dependent exocytosis, with a few signaling and neuronal growth terms that can tie to membrane trafficking in neurons. Together, they point to a theme of vesicle trafficking and membrane dynamics, rather than a single enzymatic function or pathway. Some terms are more peripheral (cell cycle, bipolar cell growth), so the label is a best-fit for a cohesive subset of functions present in the cluster. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":3},{"id":"GO:1902953","count":3},{"id":"GO:1902824","count":3},{"id":"GO:0031584","count":3},{"id":"GO:0007224","count":3}]},{"hash":"661369653754783136","title":"Membrane transport and vesicle trafficking","description":"The top GO terms cluster around transport across membranes (phosphate and iron ion import), ER-to-Golgi vesicle transport, and organelle maintenance processes like reticulophagy and lysosomal pH regulation, with some cytoskeletal/migration-related terms. This suggests a shared theme centered on membrane transport and intracellular trafficking, rather than a single direct pathway. Confidence: Medium","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006817","count":1},{"id":"GO:0030521","count":1},{"id":"GO:0061709","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0071803","count":1}]},{"hash":"1132556325857796710","title":"Telomere maintenance and cell cycle control","description":"The cluster\u2019s strongest signals are telomere-related: positive regulation of telomere maintenance via telomerase and establishment of protein localization to telomeres, alongside cell division and cell cycle terms. Immune/inflammatory and virion assembly terms are present but less cohesive, so the core theme ties telomere maintenance to cell cycle regulation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:1904851","count":3},{"id":"GO:0002842","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0032212","count":3},{"id":"GO:0051086","count":3}]},{"hash":"377643683331563463","title":"RNA Processing and Translation Regulation","description":"Based on GO terms centered on mRNA stabilization, miRNA-mediated gene silencing, spliceosome regulation, and translation initiation, the proteins in this cluster appear involved in post-transcriptional control of gene expression. While a couple signaling-related terms are present, the dominant pattern points to RNA processing and regulation of translation.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0000200","count":2},{"id":"GO:0070373","count":2},{"id":"GO:0050860","count":2},{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1}]},{"hash":"60056546924565845","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070212","count":1},{"id":"GO:0030150","count":1},{"id":"GO:0030330","count":1},{"id":"GO:1990966","count":1},{"id":"GO:0045666","count":1}]},{"hash":"2236009974122905970","title":"RNA transcription and ribosome biogenesis","description":"Cluster dominated by transcription-related GO terms across RNA polymerases I, II, and III, plus RNA-templated transcription and ribosome biogenesis, pointing to a core role in RNA synthesis and ribosome assembly. Minor terms about junctions and barriers appear incidental. Overall, the label captures the central theme of transcription and ribosome production.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006386","count":1},{"id":"GO:0001172","count":1},{"id":"GO:0006366","count":1},{"id":"GO:0006385","count":1},{"id":"GO:0042797","count":1}]},{"hash":"1404436242106985588","title":"Glycine and monoamine neurotransmission","description":"Top terms indicate glycine transport, glycinergic synaptic transmission, glycine import/secretion, and uptake/metabolism of dopamine and serotonin, pointing to a shared role in neurotransmitter handling at synapses. While a few development-related terms are present, the dominant pattern is neurotransmitter transport and signaling, especially glycine- and monoamine-related processes.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015734","count":1},{"id":"GO:0021794","count":1},{"id":"GO:0060012","count":1},{"id":"GO:0051583","count":1},{"id":"GO:0042066","count":1}]},{"hash":"518286949046624214","title":"Embryonic development and organogenesis","description":"Most top GO terms describe embryonic development and tissue differentiation across multiple organs (heart, eye, somites, podocytes, hypothalamus). The common thread is developmental morphogenesis and cell differentiation rather than a single cohesive pathway, so the label reflects broad developmental functions rather than a specific process. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060038","count":2},{"id":"GO:0033686","count":1},{"id":"GO:0048048","count":1},{"id":"GO:0061381","count":1},{"id":"GO:0001756","count":1}]},{"hash":"1995481043282428082","title":"Embryonic and limb morphogenesis","description":"These GO terms cluster around morphogenesis and development, with multiple items pointing to embryonic morphogenesis and limb morphogenesis across tissues (eye, forelimb, hindlimb, cortex). This suggests the proteins are linked to developmental patterning and morphogenesis rather than a single tissue-specific function, despite one outlier term (menaquinone biosynthesis) present. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009234","count":2},{"id":"GO:0048048","count":1},{"id":"GO:0010089","count":1},{"id":"GO:0007479","count":1},{"id":"GO:0048853","count":1}]},{"hash":"92919294153002405","title":"Unknown","description":"The top GO terms are highly diverse, spanning transcriptional regulation and RNA processing (e.g., negative regulation of transcription factor activity, alternative mRNA splicing, histone deacetylation) alongside various development, metabolism, and DNA damage response processes. There\u2019s no clear, cohesive functional theme tying all terms together, so a concise, representative label isn\u2019t apparent.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043433","count":2},{"id":"GO:0042551","count":2},{"id":"GO:0006579","count":1},{"id":"GO:0010725","count":1},{"id":"GO:1902681","count":1}]},{"hash":"2192924194817192476","title":"Unknown","description":"The GO terms across the cluster are highly heterogeneous, spanning immune signaling, neural development, fungal response, and other processes, with no clear shared function or pathway. With only three proteins and a scattered term set, there isn't a coherent theme to assign a specific label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000077","count":1},{"id":"GO:0002431","count":1},{"id":"GO:0070667","count":1},{"id":"GO:0038063","count":1},{"id":"GO:0070102","count":1}]},{"hash":"1691830940390573243","title":"Embryonic muscle and neural differentiation","description":"The top GO terms indicate roles in skeletal muscle fiber development and myoblast fate determination, alongside neural/glial differentiation and neural crest\u2013related processes, somitogenesis, and inner ear cell differentiation. This pattern points to proteins involved in early embryonic cell fate decisions across muscle and neural lineages, suggesting a developmental regulator cluster oriented around muscle and neural lineage differentiation.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0060766","count":3},{"id":"GO:0045668","count":3},{"id":"GO:0048743","count":2},{"id":"GO:0021892","count":2},{"id":"GO:0048711","count":2}]},{"hash":"138318008106725479","title":"Cholesterol biosynthesis and lipid homeostasis","description":"This cluster is driven by GO terms tied to cholesterol production and lipid regulation: cholesterol biosynthetic process, sphingolipid metabolic process, cholesterol homeostasis, and regulation/positive regulation of cholesterol flux. While a few developmental terms appear (e.g., mammary gland differentiation), the core signal centers on cholesterol metabolism and lipid regulation, suggesting these proteins function together in lipid biosynthesis and homeostasis pathways.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006695","count":3},{"id":"GO:0008542","count":3},{"id":"GO:0021522","count":2},{"id":"GO:0006665","count":2},{"id":"GO:0045540","count":2}]},{"hash":"2260699918976452751","title":"Unknown","description":"This cluster's GO terms span immune signaling, development, matrix adhesion, and other unrelated processes, with no clear common theme or interactions to bind them into a single function.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046856","count":2},{"id":"GO:0000077","count":1},{"id":"GO:0002431","count":1},{"id":"GO:0070667","count":1},{"id":"GO:0038063","count":1}]},{"hash":"179683217472406812","title":"Neuronal development and synapse maturation","description":"These GO terms center on neural development and synaptic biology, with emphasis on dendritic spine development, synapse maturation, and long-term synaptic plasticity. While a few terms touch on photoreceptor development and Notch signaling, many entries reflect processes driving neuronal differentiation, synapse formation, and regulation of synaptic components (including endocytosis). Overall, the cluster appears to represent neural development and synaptic maturation.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071230","count":1},{"id":"GO:0051491","count":1},{"id":"GO:0048170","count":1},{"id":"GO:0070086","count":1},{"id":"GO:0035204","count":1}]},{"hash":"370290558067837804","title":"Retroviral Integration and Latency","description":"The top GO terms cluster around entry of viral genomes into host cells, reverse transcription and DNA integration, genome replication, and establishment of proviral latency, with links to host RNAi suppression and apoptosis modulation. This pattern strongly points to retroviral or proviral lifecycle activities, i.e., genome integration and long-term persistence as a provirus.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075732","count":1},{"id":"GO:0046718","count":1},{"id":"GO:0039651","count":1},{"id":"GO:0075713","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1287273805906619572","title":"Unknown","description":"Unknown","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006313","count":1},{"id":"GO:0006296","count":1},{"id":"GO:0006363","count":1},{"id":"GO:0006362","count":1},{"id":"GO:0006366","count":1}]},{"hash":"1278474174167504272","title":"Mitochondrial Electron Transport and Apoptosis","description":"The GO terms cluster around mitochondrial respiration (cytochrome c\u2013related electron transport, cytochrome c\u2013heme linkage) and apoptosis (apoptotic process, caspase-related activity). Hydrogen peroxide metabolism and ROS signaling further support a mitochondrial context, with a few peripheral terms like photosynthesis and carbon monoxide response not altering the core theme. Overall, these proteins are best described as involved in mitochondria-driven energy production and cytochrome c\u2013mediated apoptosis.","confidence":"High","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0010730","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0006123","count":3},{"id":"GO:0006122","count":3},{"id":"GO:0006470","count":3}]},{"hash":"1271518356765525211","title":"Intra-Golgi vesicle transport","description":"The top GO term is intra-Golgi vesicle-mediated transport, indicating a shared role in Golgi-specific vesicle trafficking. With no edges or connections and only this single term represented, the cluster appears to reflect a focused Golgi transport function rather than broader network interactions, justifying the label as Intra-Golgi vesicle transport.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006891","count":1}]},{"hash":"2138841134991230901","title":"Unknown","description":"The top GO terms for this cluster are highly diverse and span photosynthesis, development, metabolism, redox processes, xenobiotic degradation, and stress responses, with no clear shared function tying the three proteins together. Because there is no coherent common theme, a meaningful, concise label cannot be assigned beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060992","count":1},{"id":"GO:0010725","count":1},{"id":"GO:0015979","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0016575","count":1}]},{"hash":"1334897877456968326","title":"RNA processing and translational regulation","description":"GO terms clustering around spliceosome-mediated mRNA processing (splicing, polyadenylation, Small-subunit processome), mRNA stabilization, and translation control (IRES initiation, translation reinitiation, miRNA and ncRNA\u2013mediated silencing) suggest a group of proteins involved in post-transcriptional RNA metabolism and regulation of gene expression at the RNA and translation levels.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034462","count":1},{"id":"GO:0075522","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0048255","count":1},{"id":"GO:0035278","count":1}]},{"hash":"743452069951969479","title":"T cell immune activation and apoptotic signaling","description":"Based on GO terms, there is a consistent theme of T cell\u2013related immune processes: cytokine production, innate immune signaling activation, and T cell\u2013specific apoptotic processes. The other terms (protein retention in ER lumen and protein transport) are general cellular processes that could support protein handling in immune cells but do not form a separate cohesive theme. Therefore the cluster can reasonably be summarized as T cell\u2013mediated immune activation with apoptosis signaling.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0002369","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0010204","count":1},{"id":"GO:0070231","count":1},{"id":"GO:0015031","count":1}]},{"hash":"1208228501529375124","title":"Unknown","description":"The annotated terms cover metabolism (one-carbon, tetrahydrofolate, tRNA queuosine biosynthesis), neurotransmitter biosynthesis (dopamine), and immune/vascular signaling (lipopolysaccharide and TNF responses, vasodilation, nitric oxide regulation, blood pressure). There is no single cohesive function that clearly ties all terms together for this cluster, so a reliable, concise label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008616","count":1},{"id":"GO:0048265","count":1},{"id":"GO:0006730","count":1},{"id":"GO:0042311","count":1},{"id":"GO:0032496","count":1}]},{"hash":"227025224574868567","title":"Fatty Acid Elongation and Steroid Biosynthesis","description":"The Top GO terms point to lipid metabolism and steroid hormone production, including fatty acid elongation, methyl-branched fatty acid biosynthesis, and biosynthesis of testosterone and estrogen. While some terms (retinal metabolism, lung development, plant alkaloid biosynthesis) seem unrelated, the strongest signal comes from lipid-building and hormone biosynthesis processes, supporting a cohesive label around lipid and steroid pathways.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":1},{"id":"GO:0071768","count":1},{"id":"GO:1902321","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0009710","count":1}]},{"hash":"1625437640890014219","title":"Calcium signaling in muscle and cardiac conduction","description":"The top GO terms cluster around calcium handling in muscle and heart, including regulation of SR calcium release, mitochondrial calcium, and cardiac conduction, with supporting links to muscle cytoskeletal context; a few terms are less connected, but the central theme is calcium signaling in muscle/heart function.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051764","count":1},{"id":"GO:0051562","count":1},{"id":"GO:0032516","count":1},{"id":"GO:0010880","count":1},{"id":"GO:1901844","count":1}]},{"hash":"620413031323708639","title":"Unknown","description":"The GO terms span retinal metabolism, hormone biosynthesis, lung development, bacterial and plant-specific biosynthetic and catabolic processes, with no clear single function tying all proteins together.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042574","count":1},{"id":"GO:0071768","count":1},{"id":"GO:0030324","count":1},{"id":"GO:0009710","count":1},{"id":"GO:0045150","count":1}]},{"hash":"744205199742228931","title":"Cerebellar development and actin signaling","description":"The most specific and recurrent GO terms point to cerebellar development (cerebellar cortex formation, Purkinje cell migration) and cytoskeletal dynamics (actin crosslinking, podosome assembly), suggesting a cluster centered on cerebellar neuronal development with associated actin remodeling. Other immune or signaling terms appear as peripheral signals and do not form a cohesive alternative theme, so the cerebellar-development-with-cytoskeletal signaling interpretation best captures the core pattern.","confidence":"Low","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000077","count":1},{"id":"GO:0051764","count":1},{"id":"GO:0002431","count":1},{"id":"GO:0070667","count":1},{"id":"GO:0038063","count":1}]}]