{"hash":"1849196277244895313","title":"Signaling Regulation and Proteostasis","description":"The cluster features GO terms focused on positive regulation of various signaling pathways (NF-kappaB/I-kappaB, intracellular estrogen receptor signaling, and cell surface receptor signaling) alongside processes related to protein turnover (proteasomal ubiquitin-dependent degradation and ufmylation) and protein localization to the ER. This suggests a theme of coordinated modulation of signaling activities with proteostasis mechanisms, rather than a single enzyme or pathway. Therefore, a label capturing both signaling regulation and proteostasis is appropriate.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"XXQ29699.1","go_terms":[]},{"accession":"XXQ34900.1","go_terms":["GO:1905552","GO:0032436","GO:0051092","GO:1905050","GO:1990592","GO:0033146","GO:1903721","GO:1905636"]},{"accession":"XXQ38552.1","go_terms":[]},{"accession":"XXQ37054.1","go_terms":["GO:0042220","GO:0051965","GO:0007166"]},{"accession":"XXQ35118.1","go_terms":[]},{"accession":"XXQ37694.1","go_terms":["GO:0034553","GO:0006120"]},{"accession":"XXQ38207.1","go_terms":["GO:0009247","GO:0009405","GO:0097502","GO:0008654","GO:0006490","GO:0033577","GO:0046488","GO:0010125","GO:0071793","GO:0009103","GO:1901133","GO:0006506","GO:0007631","GO:0009413","GO:0009414","GO:0072708","GO:0009744","GO:0005978","GO:0005985","GO:0010555","GO:0006006","GO:0019252"]},{"accession":"XXQ35710.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0051092":1,"GO:1990592":1,"GO:0033146":1,"GO:1905636":1,"GO:1905552":1,"GO:1903721":1,"GO:1905050":1,"GO:0032436":1,"GO:0042220":1,"GO:0007166":1,"GO:0051965":1,"GO:0034553":1,"GO:0006120":1,"GO:0009247":1,"GO:0009405":1,"GO:0010125":1,"GO:0006006":1,"GO:1901133":1,"GO:0097502":1,"GO:0008654":1,"GO:0033577":1,"GO:0046488":1,"GO:0019252":1,"GO:0006506":1,"GO:0005985":1,"GO:0010555":1,"GO:0005978":1,"GO:0072708":1,"GO:0009103":1,"GO:0007631":1,"GO:0071793":1,"GO:0006490":1,"GO:0009744":1,"GO:0009414":1,"GO:0009413":1},"recipe_readded":["XXQ36665.1","XXQ36074.1","XXQ39429.1","XXQ38366.1","XXQ38218.1","XXQ30857.1","XXQ39558.1","XXQ35023.1","XXQ38694.1","XXQ29796.1","XXQ34843.1","XXQ33003.1","XXQ32169.1","XXQ36880.1","XXQ31985.1","XXQ32533.1","XXQ38037.1","XXQ37440.1","XXQ31017.1","XXQ33114.1"]}