{"hash":"742434013117542910","title":"Ubiquitin-Proteasome Proteolysis in Neurons","description":"This cluster is dominated by GO terms for ubiquitin-dependent proteolysis and SCF-dependent proteasomal degradation, indicating a core theme of protein catabolism via the ubiquitin-proteasome system. The presence of neuron-related terms such as synapse assembly, plus stress-response terms (metal exposure, circadian regulation, oxidative stress\u2013induced apoptotic signaling), suggests the proteolytic activity is particularly relevant in neuronal contexts and stress conditions. Therefore, a concise label focusing on ubiquitin-mediated protein degradation in neurons captures the central function of the cluster.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"members":[{"accession":"KAF7760338.1","go_terms":[]},{"accession":"KAF7760661.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7761915.1","go_terms":[]},{"accession":"KAF7763461.1","go_terms":[]},{"accession":"KAF7764077.1","go_terms":[]},{"accession":"KAF7768203.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7770517.1","go_terms":[]},{"accession":"KAF7770680.1","go_terms":[]},{"accession":"KAF7770692.1","go_terms":["GO:0060386","GO:0031571","GO:0071406","GO:0031146","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7771052.1","go_terms":[]},{"accession":"KAF7773331.1","go_terms":[]},{"accession":"KAF7776561.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556"]},{"accession":"KAF7777678.1","go_terms":[]},{"accession":"KAF7782093.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7782094.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7782939.1","go_terms":["GO:0008285","GO:0070544","GO:0031146","GO:0046785","GO:0006516","GO:0007057","GO:0021678","GO:0021993","GO:0051436","GO:0001556","GO:0060386","GO:0031571","GO:0071406","GO:1902916","GO:0071276","GO:0030174","GO:0042752","GO:1903378","GO:0042787","GO:0046685","GO:0000083","GO:0000209"]},{"accession":"KAF7783872.1","go_terms":[]},{"accession":"KAF7784228.1","go_terms":[]}],"graph":[],"all_go_terms":{"GO:0031571":6,"GO:0042787":6,"GO:0060386":6,"GO:1903378":6,"GO:0000083":6,"GO:0071406":6,"GO:1902916":6,"GO:0071276":6,"GO:0042752":6,"GO:0000209":6,"GO:0046685":6,"GO:0030174":6,"GO:0031146":7,"GO:0008285":4,"GO:0021993":4,"GO:0007057":4,"GO:0021678":4,"GO:0006516":4,"GO:0051436":4,"GO:0001556":4,"GO:0070544":4,"GO:0046785":4},"recipe_readded":["KAF7776173.1","KAF7759792.1","KAF7770724.1","KAF7763664.1","KAF7784094.1","KAF7767868.1","KAF7759790.1","KAF7778894.1","KAF7778514.1","KAF7759637.1","KAF7777487.1","KAF7763645.1","KAF7760199.1","KAF7775914.1","KAF7777536.1","KAF7784464.1"]}