{"hash":"272224401273497747","title":"Ubiquitin-Regulated DNA Damage Response and Apoptosis","description":"The cluster is dominated by ubiquitination-related proteins and DNA damage/repair processes (DNA replication, DSB repair via sister chromatids, repair pathways), along with mitotic spindle assembly and cell death signals (apoptosis and pyroptosis) and innate immune response. This suggests a cohesive module where ubiquitin signaling coordinates DDR during replication stress and mitosis, leading to repair, checkpoint control, and programmed cell death, with inflammatory signaling as a possible downstream effect.","confidence":"High","size":11,"edges":35,"triangles":50,"max_degree":9,"top_function":null,"members":[{"accession":"KAF7761250.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7761266.1","go_terms":["GO:0006260","GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7761324.1","go_terms":["GO:0006260","GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7770211.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7770786.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7770787.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7770789.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7771690.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7773436.1","go_terms":["GO:0045087","GO:0006915","GO:0070269","GO:0016567","GO:0090307","GO:1990001"]},{"accession":"KAF7776047.1","go_terms":[]},{"accession":"KAF7777514.1","go_terms":["GO:0000722","GO:2000269","GO:0071480","GO:0009636","GO:0051106","GO:0090267","GO:0036297","GO:0000732","GO:0007294","GO:0007066","GO:0007533","GO:0007141","GO:0010165","GO:0001541","GO:1990918","GO:0009949","GO:0051260","GO:0007129","GO:0000707","GO:0001556","GO:1990426","GO:0072757","GO:0000709","GO:0072719","GO:0010569","GO:0072711","GO:0007286","GO:0042148","GO:0007131","GO:0007130","GO:1904631","GO:0090656","GO:0009951","GO:0045003","GO:0006268","GO:0001832","GO:0030491","GO:0042493","GO:0030717","GO:1990414","GO:0001932","GO:0071140","GO:0006276"]}],"graph":[["KAF7770787.1","KAF7761250.1",0.808],["KAF7770787.1","KAF7761324.1",0.888],["KAF7770787.1","KAF7770211.1",0.55],["KAF7770787.1","KAF7776047.1",0.619],["KAF7770787.1","KAF7773436.1",0.53],["KAF7770211.1","KAF7761250.1",0.9],["KAF7770211.1","KAF7761266.1",0.718],["KAF7770211.1","KAF7761324.1",0.953],["KAF7770211.1","KAF7771690.1",0.642],["KAF7770211.1","KAF7770789.1",0.566],["KAF7770211.1","KAF7773436.1",0.576],["KAF7770211.1","KAF7776047.1",0.586],["KAF7776047.1","KAF7761250.1",0.593],["KAF7776047.1","KAF7761266.1",0.725],["KAF7776047.1","KAF7761324.1",0.794],["KAF7776047.1","KAF7770786.1",0.61],["KAF7776047.1","KAF7771690.1",0.681],["KAF7776047.1","KAF7773436.1",0.717],["KAF7776047.1","KAF7777514.1",0.554],["KAF7773436.1","KAF7761250.1",0.654],["KAF7773436.1","KAF7761266.1",0.777],["KAF7773436.1","KAF7761324.1",0.765],["KAF7777514.1","KAF7761250.1",0.727],["KAF7777514.1","KAF7761266.1",0.804],["KAF7777514.1","KAF7761324.1",0.792],["KAF7777514.1","KAF7771690.1",0.571],["KAF7770786.1","KAF7761250.1",0.776],["KAF7770786.1","KAF7761266.1",0.652],["KAF7770786.1","KAF7761324.1",0.701],["KAF7761250.1","KAF7761266.1",0.828],["KAF7761250.1","KAF7761324.1",0.674],["KAF7761250.1","KAF7770789.1",0.586],["KAF7761266.1","KAF7761324.1",0.878],["KAF7761266.1","KAF7770789.1",0.594],["KAF7761324.1","KAF7770789.1",0.782]],"all_go_terms":{"GO:0016567":9,"GO:0090307":9,"GO:0006915":9,"GO:0045087":9,"GO:1990001":9,"GO:0070269":9,"GO:0006260":2,"GO:1990414":1,"GO:0045003":1,"GO:0072711":1,"GO:0007286":1,"GO:0090267":1,"GO:0072757":1,"GO:0051106":1,"GO:0001541":1,"GO:2000269":1,"GO:0000707":1,"GO:0010569":1,"GO:0007131":1,"GO:0001832":1,"GO:0030491":1,"GO:1904631":1,"GO:0072719":1,"GO:0000722":1,"GO:0007066":1,"GO:0009951":1,"GO:0090656":1,"GO:0042493":1,"GO:0006276":1,"GO:0006268":1,"GO:1990918":1,"GO:0009949":1,"GO:0007533":1,"GO:0007129":1,"GO:0007294":1,"GO:0071480":1,"GO:0001556":1,"GO:1990426":1,"GO:0036297":1,"GO:0000709":1,"GO:0010165":1,"GO:0007130":1,"GO:0030717":1,"GO:0071140":1,"GO:0000732":1,"GO:0042148":1,"GO:0001932":1,"GO:0051260":1,"GO:0009636":1,"GO:0007141":1},"recipe_readded":[]}