{"hash":"817499013565789634","title":"ER protein quality control and membrane trafficking","description":"Most top GO terms point to ER-associated processes: ubiquitin-dependent ERAD pathway, protein deglycosylation, and tail-anchored insertion into the ER membrane, along with regulation of proteasomal degradation and ER-related calcium signaling. Although a few terms touch on mitochondria, cell division, or neural development, the core theme is ER-based protein processing and quality control, which justifies the label.","confidence":"Medium","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"members":[{"accession":"RMX38963.1","go_terms":["GO:0032436","GO:0070911","GO:0034126","GO:0090204","GO:0010286","GO:1901896","GO:0071276","GO:0043392","GO:0060334","GO:0051572","GO:0016925","GO:0043433","GO:0035186","GO:0086004","GO:0030578","GO:1902260","GO:0045944","GO:0045759","GO:0060340","GO:1901097","GO:0006468","GO:1901340","GO:0035458","GO:0000226","GO:0030010","GO:0001828","GO:0001827","GO:1903094","GO:1904153","GO:2000157","GO:0010994","GO:0035973","GO:1904378","GO:0030474","GO:0032815","GO:1903071","GO:0006289","GO:0034140","GO:0035523","GO:0030433","GO:0035278","GO:0035329","GO:0044313","GO:1900186","GO:0070059","GO:0016567","GO:1904021","GO:0006517","GO:0000423","GO:0033132","GO:1902236","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:1901799","GO:1902283","GO:0016579","GO:0017085","GO:0051865","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1904049","GO:0006412"]},{"accession":"RMX40359.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"RMX40523.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"RMX44278.1","go_terms":["GO:0051603","GO:0050790","GO:0097067","GO:0001957","GO:0010815","GO:0010813","GO:0030574","GO:2000179","GO:0001913","GO:0060441","GO:0034769","GO:0060448","GO:0046697","GO:0045453","GO:0035593"]},{"accession":"RMX44425.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412"]},{"accession":"RMX48166.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907","GO:0009306"]},{"accession":"RMX48868.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"RMX49818.1","go_terms":["GO:0060325"]},{"accession":"RMX49915.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"RMX52132.1","go_terms":["GO:0034727","GO:0000422","GO:0061723","GO:0006501","GO:0035096","GO:0044805","GO:0032258","GO:0000045","GO:0000226","GO:0034198","GO:0010940","GO:0010040","GO:0034629","GO:0040024","GO:0008625","GO:0006888","GO:0097352","GO:0071211","GO:0070301","GO:0010288","GO:0061709","GO:0006915","GO:0043278","GO:0071280","GO:0070257"]},{"accession":"RMX52394.1","go_terms":["GO:0000423","GO:1901097","GO:0033132","GO:1902236","GO:1901340","GO:1903265","GO:0021888","GO:0014070","GO:0010216","GO:0045648","GO:0002109","GO:0006357","GO:0035973","GO:1901799","GO:1902283","GO:0016579","GO:1904378","GO:0030474","GO:0017085","GO:1903071","GO:0006289","GO:0051865","GO:0034140","GO:0030433","GO:0016925","GO:1905366","GO:0000028","GO:0010636","GO:0010637","GO:0000753","GO:0071816","GO:0070842","GO:0097237","GO:1900186","GO:1904021","GO:0006517","GO:1904049","GO:0006412","GO:0019731","GO:0002227"]},{"accession":"RMX52872.1","go_terms":["GO:0099641","GO:0071480","GO:0032387","GO:0050821","GO:0032355","GO:0009644","GO:0030308","GO:0032463","GO:2000378","GO:0070309","GO:0006936","GO:0070141","GO:0031109","GO:0009408","GO:0007568","GO:0042542","GO:1900034","GO:0051403","GO:1905907"]},{"accession":"RMX45199.1","go_terms":["GO:0000266","GO:0048140","GO:1990182","GO:0001731","GO:0075522","GO:0016559","GO:0043161","GO:0035871","GO:0070452","GO:0070537","GO:0006281","GO:0000338","GO:0006446","GO:0045471","GO:0010387","GO:0035522","GO:0010950","GO:0014067","GO:0000393","GO:0034286","GO:0051726","GO:1902906","GO:0000398","GO:1903894"]},{"accession":"RMX58357.1","go_terms":["GO:0006284","GO:0097510"]}],"graph":[["RMX49915.1","RMX48166.1",0.974],["RMX49915.1","RMX48868.1",0.977],["RMX49915.1","RMX52872.1",0.946],["RMX49915.1","RMX52132.1",0.911],["RMX49915.1","RMX52394.1",0.975],["RMX49915.1","RMX49818.1",0.903],["RMX49915.1","RMX58357.1",0.962],["RMX49915.1","RMX38963.1",0.875],["RMX49915.1","RMX40359.1",0.933],["RMX49915.1","RMX40523.1",0.975],["RMX49915.1","RMX44278.1",0.949],["RMX49915.1","RMX44425.1",0.876],["RMX49915.1","RMX45199.1",0.858],["RMX40359.1","RMX38963.1",0.977],["RMX40359.1","RMX40523.1",0.974],["RMX40359.1","RMX48868.1",0.981],["RMX40359.1","RMX48166.1",0.979],["RMX40359.1","RMX45199.1",0.945],["RMX40359.1","RMX44278.1",0.97],["RMX40359.1","RMX44425.1",0.961],["RMX40359.1","RMX52872.1",0.919],["RMX40359.1","RMX52132.1",0.926],["RMX40359.1","RMX52394.1",0.961],["RMX40359.1","RMX49818.1",0.934],["RMX40359.1","RMX58357.1",0.96],["RMX40523.1","RMX38963.1",0.991],["RMX40523.1","RMX48868.1",0.988],["RMX40523.1","RMX48166.1",0.948],["RMX40523.1","RMX45199.1",0.955],["RMX40523.1","RMX44278.1",0.983],["RMX40523.1","RMX44425.1",0.988],["RMX40523.1","RMX52872.1",0.968],["RMX40523.1","RMX52132.1",0.961],["RMX40523.1","RMX52394.1",0.975],["RMX40523.1","RMX49818.1",0.979],["RMX40523.1","RMX58357.1",0.988],["RMX48166.1","RMX52872.1",0.965],["RMX48166.1","RMX52132.1",0.949],["RMX48166.1","RMX52394.1",0.953],["RMX48166.1","RMX49818.1",0.883],["RMX48166.1","RMX58357.1",0.958],["RMX48166.1","RMX38963.1",0.96],["RMX48166.1","RMX44278.1",0.965],["RMX48166.1","RMX44425.1",0.95],["RMX48166.1","RMX45199.1",0.851],["RMX48166.1","RMX48868.1",0.948],["RMX38963.1","RMX44425.1",0.962],["RMX38963.1","RMX45199.1",0.92],["RMX38963.1","RMX48868.1",0.993],["RMX38963.1","RMX49818.1",0.984],["RMX38963.1","RMX52132.1",0.917],["RMX38963.1","RMX52394.1",0.987],["RMX38963.1","RMX52872.1",0.986],["RMX38963.1","RMX58357.1",0.991],["RMX48868.1","RMX49818.1",0.958],["RMX48868.1","RMX52132.1",0.971],["RMX48868.1","RMX52394.1",0.961],["RMX48868.1","RMX52872.1",0.979],["RMX48868.1","RMX58357.1",0.963],["RMX48868.1","RMX44278.1",0.979],["RMX48868.1","RMX44425.1",0.987],["RMX48868.1","RMX45199.1",0.87],["RMX52132.1","RMX49818.1",0.955],["RMX52132.1","RMX52394.1",0.875],["RMX52132.1","RMX52872.1",0.956],["RMX52132.1","RMX58357.1",0.977],["RMX52132.1","RMX44278.1",0.82],["RMX52132.1","RMX44425.1",0.94],["RMX52132.1","RMX45199.1",0.951],["RMX52394.1","RMX49818.1",0.972],["RMX52394.1","RMX52872.1",0.973],["RMX52394.1","RMX58357.1",0.977],["RMX52394.1","RMX44278.1",0.98],["RMX52394.1","RMX44425.1",0.944],["RMX52394.1","RMX45199.1",0.905],["RMX52872.1","RMX49818.1",0.914],["RMX52872.1","RMX58357.1",0.953],["RMX52872.1","RMX44278.1",0.965],["RMX52872.1","RMX44425.1",0.96],["RMX52872.1","RMX45199.1",0.882],["RMX58357.1","RMX44278.1",0.92],["RMX58357.1","RMX44425.1",0.989],["RMX58357.1","RMX45199.1",0.914],["RMX58357.1","RMX49818.1",0.936],["RMX49818.1","RMX44278.1",0.923],["RMX49818.1","RMX44425.1",0.977],["RMX49818.1","RMX45199.1",0.776],["RMX44425.1","RMX44278.1",0.898],["RMX44425.1","RMX45199.1",0.941],["RMX45199.1","RMX44278.1",0.932]],"all_go_terms":{"GO:0030433":4,"GO:0006517":4,"GO:0030010":1,"GO:0010636":4,"GO:1901799":4,"GO:0071816":4,"GO:0045944":1,"GO:0043433":1,"GO:0030474":4,"GO:0000753":4,"GO:0010286":1,"GO:1901340":4,"GO:0060340":1,"GO:0034126":1,"GO:1901896":1,"GO:0035523":1,"GO:0021888":4,"GO:0014070":4,"GO:0030578":1,"GO:1904021":4,"GO:1902283":4,"GO:0051865":4,"GO:0051572":1,"GO:0010637":4,"GO:2000157":1,"GO:0070842":4,"GO:0060334":1,"GO:1904153":1,"GO:0032436":1,"GO:1902260":1,"GO:0006412":4,"GO:0071276":1,"GO:0043392":1,"GO:1900186":4,"GO:0000423":4,"GO:1903071":4,"GO:0006357":4,"GO:1903094":1,"GO:0010994":1,"GO:1903265":4,"GO:1905366":4,"GO:0001828":1,"GO:0034140":4,"GO:1901097":4,"GO:0033132":4,"GO:0001827":1,"GO:0032815":1,"GO:0002109":4,"GO:0017085":4,"GO:0035329":1,"GO:0044313":1,"GO:0006468":1,"GO:0016567":1,"GO:0010216":4,"GO:1904378":4,"GO:0016925":4,"GO:0090204":1,"GO:0070911":1,"GO:0035186":1,"GO:0045759":1,"GO:0070059":1,"GO:0035458":1,"GO:1902236":4,"GO:0035973":4,"GO:0000028":4,"GO:0086004":1,"GO:0035278":1,"GO:0016579":4,"GO:0006289":4,"GO:0000226":3,"GO:1904049":4,"GO:0045648":4,"GO:0097237":4,"GO:0071211":2,"GO:0071280":2,"GO:0006888":2,"GO:0034727":2,"GO:0010940":2,"GO:0010288":2,"GO:0070257":2,"GO:0097352":2,"GO:0006501":2,"GO:0061723":2,"GO:0034629":2,"GO:0008625":2,"GO:0010040":2,"GO:0061709":2,"GO:0000422":2,"GO:0044805":2,"GO:0006915":2,"GO:0035096":2,"GO:0032258":2,"GO:0070301":2,"GO:0043278":2,"GO:0000045":2,"GO:0040024":2,"GO:0034198":2,"GO:0001957":1,"GO:0051603":1,"GO:0010815":1,"GO:0060441":1,"GO:0060448":1,"GO:0010813":1,"GO:2000179":1,"GO:0001913":1,"GO:0046697":1,"GO:0045453":1,"GO:0030574":1,"GO:0097067":1,"GO:0035593":1,"GO:0050790":1,"GO:0034769":1,"GO:0070309":4,"GO:0007568":4,"GO:0009408":4,"GO:0042542":4,"GO:0006936":4,"GO:0009644":4,"GO:0071480":4,"GO:0031109":4,"GO:0032463":4,"GO:0032387":4,"GO:0051403":4,"GO:0009306":1,"GO:0099641":4,"GO:0032355":4,"GO:2000378":4,"GO:1905907":4,"GO:0070141":4,"GO:0050821":4,"GO:0030308":4,"GO:1900034":4,"GO:0060325":1,"GO:0002227":1,"GO:0019731":1,"GO:0045471":1,"GO:0000338":1,"GO:0006281":1,"GO:0016559":1,"GO:0034286":1,"GO:0048140":1,"GO:0010387":1,"GO:1902906":1,"GO:0000398":1,"GO:1990182":1,"GO:0075522":1,"GO:1903894":1,"GO:0010950":1,"GO:0070452":1,"GO:0035522":1,"GO:0000266":1,"GO:0035871":1,"GO:0006446":1,"GO:0001731":1,"GO:0051726":1,"GO:0070537":1,"GO:0014067":1,"GO:0043161":1,"GO:0000393":1,"GO:0006284":1,"GO:0097510":1},"recipe_readded":[]}