[{"hash":"1163656189070463645","title":"Ubiquitin-Dependent Protein Degradation","description":"The cluster is enriched for ubiquitin-related catabolic processes and proteasome-dependent degradation, with many terms for SCF-dependent ubiquitination, autoubiquitination, and specific ubiquitin linkages (K6, K11). This supports a cohesive module centered on tagging proteins for destruction. A few proteins also relate to peroxisomal import or DNA repair, but the dominant signal is ubiquitin-mediated proteolysis.","confidence":"High","size":29,"edges":213,"triangles":675,"max_degree":27,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0051865","count":15},{"id":"GO:0031146","count":13},{"id":"GO:0085020","count":11},{"id":"GO:0030433","count":10}]},{"hash":"1020470149657423674","title":"Innate Immune Response and Inflammatory Signaling","description":"The top terms cluster around innate immune processes and inflammatory signaling, including cellular responses to LPS, defense against bacteria, innate immune response, IL-1\u2013mediated signaling, and NF-kappaB activity. Some terms relate to development or metabolism (neural tube closure, cholesterol biosynthesis, mitotic cell cycle) and may be noise, but the dominant theme is innate immune activation and inflammation.","confidence":"Medium","size":29,"edges":51,"triangles":24,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":5},{"id":"GO:0071222","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0001843","count":4},{"id":"GO:0045087","count":4}]},{"hash":"163719853235507903","title":"Lectin and Fc receptor signaling; nephric and lymphatic development","description":"The cluster is dominated by immune signaling GO terms such as complement activation via the lectin pathway, stimulatory C-type lectin receptor signaling, and Fc-gamma receptor signaling, plus integrin-mediated signaling. Simultaneously, several development terms point to nephric (kidney) and lymphatic vascular morphogenesis. This mix suggests proteins involved in both lectin/Fc receptor\u2013driven immune signaling and embryonic kidney/lymphatic development, hence the combined label.","confidence":"Medium","size":29,"edges":7,"triangles":0,"max_degree":2,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":18},{"id":"GO:0007229","count":14},{"id":"GO:0071226","count":14},{"id":"GO:0060355","count":12},{"id":"GO:0072177","count":12}]},{"hash":"2102303283833869603","title":"IL-1\u2013NF-\u03baB Immune Signaling","description":"The top GO terms predominantly reflect inflammatory signaling and immune regulation, including cellular response to interleukin-1, T cell homeostasis, and NF-kappaB and ERK signaling. These core pathways point to a cohesive theme of immune activation and cytokine-driven transcriptional control, with additional development-related terms that are often tied to signaling networks.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0071347","count":6},{"id":"GO:0043029","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0006260","count":5},{"id":"GO:0033689","count":5}]},{"hash":"514299203353339739","title":"Ribosome Biogenesis and Translation","description":"This cluster is strongly enriched for processes tied to ribosomes and protein synthesis: translation, ribosome biogenesis and small subunit assembly/disassembly, and SRP-dependent cotranslational targeting to the membrane. A few terms like response to antibiotic or cell cycle appear but do not override the dominant ribosomal theme. Thus the cluster most likely reflects components of the ribosome assembly/translation machinery.","confidence":"High","size":29,"edges":405,"triangles":3627,"max_degree":28,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":15},{"id":"GO:0042254","count":7},{"id":"GO:0006407","count":5},{"id":"GO:0006415","count":5},{"id":"GO:0000028","count":4}]},{"hash":"545005941146438762","title":"Developmental differentiation and inflammatory signaling","description":"This cluster combines differentiation-related processes across tissues (keratinocyte differentiation, epithelial differentiation in prostate gland development, skeletal development) with stress and immune signaling (hypoxia response, TNF response, Notch signaling modulation, redox processes, metal ion response). The common thread appears to be developmental differentiation linked to inflammatory and stress-response pathways, though the mix is broad and some terms are obsolete or peripheral.","confidence":"Medium","size":29,"edges":4,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0001501","count":13},{"id":"GO:0031915","count":13},{"id":"GO:0071456","count":13},{"id":"GO:0060528","count":13},{"id":"GO:0007568","count":13}]},{"hash":"1927016055252417924","title":"Neuronal signaling and immune-apoptotic stress responses","description":"This cluster mixes neuronal signaling terms (negative regulation of excitatory postsynaptic potential, associative learning) with robust stress/immune signals (hypoxia response, innate immune response, pyroptotic inflammation, apoptosis) and protein ubiquitination. The common theme appears to be synaptic regulation intertwined with cellular stress responses and programmed cell death, suggesting a functional link between neural activity and immune-apoptotic pathways. ","confidence":"Medium","size":29,"edges":58,"triangles":51,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0090394","count":9},{"id":"GO:0006260","count":7},{"id":"GO:0045944","count":7},{"id":"GO:0008306","count":7},{"id":"GO:0001666","count":7}]},{"hash":"696553420681258279","title":"Developmental transcription and chromatin regulation in muscle","description":"The top GO terms cluster around DNA-templated transcription, regulation of gene expression, and histone methylation, all tied to multicellular development. The explicit entry for skeletal muscle satellite cell maintenance in muscle regeneration strongly points to transcriptional and chromatin-level control during muscle development and repair, with additional supporting roles for cell division, microtubule dynamics, and vesicle trafficking. This combination suggests a cohesive theme of gene expression regulation in muscle development/regeneration, hence the label.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0006349","count":3},{"id":"GO:0051567","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0043433","count":3}]},{"hash":"1682561456733741655","title":"Cartilage ECM and Collagen Signaling","description":"This cluster is dominated by terms related to collagen fibril organization, cartilage condensation, and collagen-activated receptor signaling, alongside cell adhesion. This points to a coherent theme of cartilage development and extracellular matrix (ECM) remodeling, with collagen as a central motif. Other terms like nervous system development and heart rate regulation may reflect broader roles of ECM interactions in development, but the strongest signal is cartilage/ collagen\u2013driven processes.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":4},{"id":"GO:0046718","count":3},{"id":"GO:0071230","count":3},{"id":"GO:0038063","count":3},{"id":"GO:0001502","count":3}]},{"hash":"1585388845930316197","title":"Unknown","description":"The top GO terms span diverse processes\u2014translation, actin filament assembly, mechanosensory pain detection, mitochondrial electron transport, neural differentiation, DNA repair, and antiviral defense\u2014indicating no single unifying function for this cluster.","confidence":"","size":29,"edges":288,"triangles":1925,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0051017","count":2},{"id":"GO:0050966","count":2},{"id":"GO:0006120","count":2},{"id":"GO:0070584","count":2}]},{"hash":"1505794545617464117","title":"Ribosome Biogenesis and Translation","description":"The cluster is dominated by terms related to protein synthesis, especially ribosome biogenesis and translation, indicating a core theme around ribosome assembly and the translation machinery. A few other terms (valine catabolism, liver development, cadmium response) are less central and likely incidental to the main function.","confidence":"Medium","size":29,"edges":278,"triangles":1240,"max_degree":24,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006574","count":2},{"id":"GO:0001889","count":2}]},{"hash":"1246478701972024197","title":"Innate immune signaling and cell cycle regulation","description":"This cluster's top GO terms center on innate immune response and NF-kappaB signaling, with notable links to cell division and spleen development. Additional terms about GTPase activity regulation and vesicle transport suggest broader regulatory roles in immune signaling and cellular trafficking. The dominant pattern is innate immune signaling components with involvement in cell cycle\u2013related processes, though the connections are not perfectly tight. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0051301","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0048536","count":4}]},{"hash":"1075905172351247385","title":"Embryonic development and morphogenesis","description":"The top GO terms cluster around diverse developmental processes (midbrain, pituitary, heart outflow tract, palate, cartilage, cranial skeleton, primitive streak, uterus). Taken together they point to broad embryonic organogenesis and tissue morphogenesis across multiple lineages, with the regulator term GO:0000122 reflecting transcriptional control during this program.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0030901","count":7},{"id":"GO:0021983","count":6},{"id":"GO:0003148","count":6},{"id":"GO:0060021","count":6}]},{"hash":"629865903439875922","title":"Unknown","description":"The top GO terms cover a wide range of processes (signaling regulation, synapse assembly, migration, development, apoptosis, antiviral defense, hormone/sugar biosynthesis, lipid metabolism, and nutrient/starvation responses) with no single dominant function. The lack of cohesive biological theme or network connectivity suggests the cluster is functionally heterogeneous rather than representing a specific, interpretable biology.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010754","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0006929","count":2},{"id":"GO:0001892","count":2},{"id":"GO:0006915","count":2}]},{"hash":"600090294726290585","title":"Neuronal development and synapse assembly","description":"The top terms cluster around neural development and connectivity, including forebrain development, dopaminergic neuron axon guidance, neuronal stem cell maintenance, and synapse assembly, indicating a brain-development/neuronal-function theme. Some terms like hair cycle and planar polarity are less central but may reflect broader developmental processes within the cluster.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030900","count":2},{"id":"GO:0071404","count":2},{"id":"GO:0042633","count":2},{"id":"GO:0090251","count":2},{"id":"GO:0007157","count":2}]},{"hash":"747678687036983324","title":"Axon Guidance and Neural Crest Migration","description":"These proteins cluster around axon guidance and neural development: multiple GO terms describe commissural axon guidance, projection guidance for sympathetic and branchiomotor neurons, trigeminal nerve organization, and semaphorin-plexin signaling. A subset also touches neural crest migration and paranodal localization, suggesting roles in guiding growing axons and organizing neural circuits. A few terms (coronary morphogenesis, classical complement activation) are less consistently connected, but the dominant theme is axon pathfinding and neural patterning.","confidence":"High","size":29,"edges":3,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0071679","count":7},{"id":"GO:0002175","count":6},{"id":"GO:0036486","count":6},{"id":"GO:0021637","count":6},{"id":"GO:1902287","count":6}]},{"hash":"1681132440437069196","title":"Neuronal vesicle trafficking and synaptic localization","description":"GO terms point to vesicle transport between ER and Golgi, intra-Golgi and vesicle docking, protein localization to the cell surface, and synaptic functions such as long-term potentiation and vesicle recycling. Together these terms suggest a coherent theme of neuronal vesicle trafficking and synaptic localization, even though the network edges are sparse. ","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051024","count":1},{"id":"GO:1902685","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0060291","count":1},{"id":"GO:0006891","count":1}]},{"hash":"912171008405687576","title":"Developmental transcriptional regulation","description":"This cluster centers on RNA Pol II\u2013mediated transcription and its regulation, with multiple development-related GO terms (embryonic development, left-right patterning, organ morphogenesis, pancreas development), indicating a shared theme of transcriptional control during development.","confidence":"High","size":29,"edges":362,"triangles":2645,"max_degree":28,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0035470","count":9},{"id":"GO:0006351","count":9},{"id":"GO:2001111","count":9},{"id":"GO:0071353","count":8}]},{"hash":"483579221016874134","title":"Epithelial morphogenesis and organ development","description":"The top GO terms point to developmental processes in epithelia and organ formation (hair follicle placode, fungiform papilla formation, lung mesenchymal proliferation) and cell\u2013cell junction assembly, suggesting a cohesive theme of tissue morphogenesis and organogenesis with related adhesion/signaling. Some regulatory terms (cell cycle, GTPase activity, calcium signaling) align with developmental remodeling, reinforcing this overall theme.","confidence":"Medium","size":29,"edges":402,"triangles":3548,"max_degree":28,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0007050","count":24},{"id":"GO:0061198","count":23},{"id":"GO:0070602","count":23},{"id":"GO:0043547","count":23},{"id":"GO:0060789","count":23}]},{"hash":"2228625215499134318","title":"Immune Activation and Vascular Remodeling","description":"This cluster shows strong signals for both immune functions (complement activation, adaptive immune response, response to fungal origin) and vascular remodeling (angiogenesis, endothelial cell migration, HGF receptor signaling, ERK/MAPK activation, RTK and integrin signaling), plus coagulation, suggesting coordinated immune-driven vascular changes.","confidence":"High","size":29,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001867","count":16},{"id":"GO:0007229","count":12},{"id":"GO:0071226","count":11},{"id":"GO:0007171","count":11},{"id":"GO:0070374","count":10}]},{"hash":"2161008596440110597","title":"Renal nephron segment development","description":"The top GO terms are dominated by metanephric nephron segment development (ascending/descending limbs and distal tubule), indicating a clear focus on kidney nephron formation. Additional terms related to morphogenesis and vascular development fit with kidney organogenesis, supporting a renal development theme. Confidence: High","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072218","count":6},{"id":"GO:0007160","count":6},{"id":"GO:0097211","count":5},{"id":"GO:0042102","count":5},{"id":"GO:0006958","count":4}]},{"hash":"22266321231517599","title":"GPCR-cAMP Signaling in Cardiovascular and Neural Systems","description":"The cluster is dominated by GPCR-cAMP related signals: adenylate cyclase-activating GPCR signaling and dopamine receptor signaling; these point to GPCR-mediated modulation of cellular responses. In addition, terms like positive regulation of blood pressure and positive regulation of renin secretion suggest cardiovascular regulation, while astrocyte chemotaxis and immune response indicate neural and immune system-related roles. An outlier term for electron transport chain hints at general cellular energy metabolism but does not define the core theme. Overall, the data converge on GPCR-cAMP signaling with cardiovascular and neural system involvement.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":28},{"id":"GO:0022900","count":28},{"id":"GO:0045777","count":28},{"id":"GO:0046849","count":26},{"id":"GO:0035025","count":26}]},{"hash":"394609568184737913","title":"RNA Pol II Transcription Regulation","description":"This cluster is dominated by GO terms for regulating transcription by RNA polymerase II (both positive and negative), indicating a core function as transcriptional regulators. The inclusion of development and coagulation terms likely reflects broader roles in development and vascular processes tied to transcriptional control. Overall, the strongest signal is RNA Pol II transcription regulation.","confidence":"High","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":13},{"id":"GO:0030901","count":9},{"id":"GO:0045944","count":7},{"id":"GO:0030194","count":7},{"id":"GO:1902947","count":6}]},{"hash":"1558396702483533782","title":"Cardiac development and stress-signaling","description":"Dominant heart development term (GO:0007507) and strong links to calcium signaling (GO:0051281), ERK/MAPK cascade (GO:0070374), and temperature-related responses (GO:0071502, GO:0002024) point to proteins involved in cardiac development and stress-activated signaling pathways. While other terms touch on immune or pain processes, the core theme is cardiac development coupled with intracellular signaling under thermal stress.","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":9},{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0043547","count":8}]},{"hash":"1171682109235947644","title":"Unknown","description":"The listed GO terms span apoptotic signaling, inflammatory TNF/NF-kB pathways, cellular responses to LPS and ATP, and some transcriptional/developmental processes, with no single dominant function linking them. The cluster has no edges, suggesting a noisy or non-cohesive collection rather than a coherent module. Therefore there is no clear unifying theme to assign a specific label.","confidence":"","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042771","count":1},{"id":"GO:0034051","count":1},{"id":"GO:0071222","count":1},{"id":"GO:0033209","count":1},{"id":"GO:0042347","count":1}]},{"hash":"1747263443832585827","title":"Visual system neural-immune signaling and trafficking","description":"These terms cluster around neural-visual tissues and immune interactions, including visual perception, paranodal junctions in neural circuits, microglia development, and vesicle/endosome transport (endosome-to-melanosome, vacuolar protein turnover). The common theme appears to be neural-immune processes and vesicular trafficking in the visual system (retina/brain), though some terms are peripheral (e.g., virion attachment, LDL response), so the connection is plausible but not tight. ","confidence":"Medium","size":29,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":3},{"id":"GO:0046813","count":3},{"id":"GO:0007601","count":3},{"id":"GO:1901223","count":3},{"id":"GO:0014005","count":2}]},{"hash":"1107667631905103787","title":"Spliceosome-regulated mRNA processing","description":"These terms cluster around spliceosome-mediated splicing and related RNA processing steps, including regulation of alternative splicing, spliceosomal assembly/disassembly, mRNA export, and processome assembly, with a broader tie to transcription regulation by RNA Pol II. Together they point to a cohesive module of RNA maturation and lifecycle control centered on the spliceosome. ","confidence":"High","size":28,"edges":156,"triangles":366,"max_degree":24,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000381","count":5},{"id":"GO:0031047","count":4},{"id":"GO:0010610","count":4},{"id":"GO:0048026","count":4},{"id":"GO:0000122","count":4}]},{"hash":"2190577507484633706","title":"Wnt signaling and transcription regulation","description":"The top terms are dominated by the Wnt signaling pathway and regulation of transcription by RNA polymerase II (both positive and negative regulation), with supporting development-related terms (roof of mouth development). While some metabolic/biosynthetic terms appear, the strongest coherent theme centers on signaling leading to transcriptional control during development, justifying a label focused on Wnt signaling and transcription regulation.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0016055","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0000122","count":4},{"id":"GO:0042619","count":4},{"id":"GO:0017000","count":4}]},{"hash":"1876071627777097973","title":"Immune signaling and miRNA regulation","description":"The top GO terms point to immune-related signaling, with positive regulation of TNF signaling and chemokine production, and host defense aspects like suppression of viral release. In addition, several terms involve RNA-based regulation, including miRNA metabolic processes and miRNA-mediated gene silencing, suggesting a combined theme of immune signaling and RNA-level gene regulation. Some terms about GTPase activity and stem cell proliferation hint at broader signaling roles but do not override the central immune/RNA regulation pattern.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":13},{"id":"GO:0007568","count":12},{"id":"GO:0030433","count":10},{"id":"GO:1903265","count":9},{"id":"GO:0035278","count":9}]},{"hash":"1463958604605571334","title":"Neuronal development and signaling","description":"This cluster is dominated by neural development terms (nervous system development, neuron development, dendrite morphogenesis) and transcriptional regulation, plus signaling pathways (Wnt signaling) and ion transport relevant to neuronal function. While some terms touch on immune signaling and chemotaxis, the neural development theme most strongly characterizes the set.","confidence":"Medium","size":28,"edges":127,"triangles":232,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":20},{"id":"GO:0006935","count":17},{"id":"GO:0007399","count":16},{"id":"GO:0043433","count":15},{"id":"GO:0048666","count":15}]},{"hash":"611329546459041425","title":"Fatty acid biosynthesis and lipid metabolism","description":"The top terms are dominated by fatty acid biosynthetic processes and related lipid metabolism (long-chain and medium-chain fatty-acyl-CoA metabolism, acetyl-CoA\u2013related biosynthesis), with lipoteichoic acid biosynthesis also tying into bacterial lipid components. Although a few terms like seed coat development and bioluminescence appear, the strongest signal centers on lipid creation and processing, supporting this label.","confidence":"High","size":28,"edges":164,"triangles":393,"max_degree":20,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0006633","count":9},{"id":"GO:0070395","count":7},{"id":"GO:0055114","count":6},{"id":"GO:0010214","count":6},{"id":"GO:0001676","count":6}]},{"hash":"1145323855339347051","title":"Neural development and axon guidance signaling","description":"The cluster is dominated by neural-related terms: nervous system development, hippocampus development, regulation of dendritic spine morphogenesis, and signaling pathways tied to axon guidance (Roundabout/ROBO and ephrin receptor signaling). These together point to processes shaping neural circuitry and synaptic connectivity. While there are a few immune or other developmental terms in the set, the core signal centers on neural development and axon guidance.","confidence":"High","size":28,"edges":115,"triangles":121,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0061001","count":5},{"id":"GO:0035385","count":5},{"id":"GO:0050852","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007399","count":5}]},{"hash":"1636629034655169383","title":"Neural development and neurotransmission","description":"The cluster is dominated by neural-related functions: visual perception, regulation of GABAergic synaptic transmission, dopamine secretion, and the ERK signaling cascade, together with developmental processes such as in utero embryonic development and lateral ventricle development, and Rho signaling in neuronal morphogenesis. While a couple of terms (hair follicle morphogenesis, apoptotic cell clearance) are more general or non-neural, the overall pattern centers on brain development and synaptic signaling.","confidence":"High","size":28,"edges":11,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0032228","count":3},{"id":"GO:0070371","count":2},{"id":"GO:0051482","count":2},{"id":"GO:0031069","count":2}]},{"hash":"2039128686530825632","title":"Neural development and progenitor proliferation","description":"Based on the prominence of nervous system development terms (nervous system development, hippocampus development, dendrite morphogenesis, regulation of axonogenesis) and concurrent cell-cycle/DNA replication terms (DNA replication, mitotic cell cycle), the cluster appears to group neural progenitors and their maturation. The cranial skeleton morphogenesis term may reflect neural crest-related processes, but the dominant theme is neural development and proliferative activity.","confidence":"High","size":28,"edges":106,"triangles":120,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":27},{"id":"GO:0048701","count":24},{"id":"GO:0048813","count":21},{"id":"GO:0000278","count":21},{"id":"GO:0007399","count":21}]},{"hash":"1593890437992647765","title":"Meiotic and mitotic chromosome cohesion and segregation","description":"The top GO terms cluster around centromeric sister chromatid cohesion, mitotic/meiosis-specific chromatid separation, and DNA replication\u2013dependent chromatin assembly, pointing to a core theme of chromosome maintenance during cell division. Additional terms like mRNA transport and lipid metabolism are present but secondary to the main function of cohesion and segregation.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051754","count":5},{"id":"GO:0042176","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0051306","count":4},{"id":"GO:1903538","count":4}]},{"hash":"2121197254479358639","title":"Translation Machinery and Ribosome Assembly","description":"This cluster is dominated by GO terms related to protein synthesis, including translation and translational termination, and ribosomal large subunit assembly, indicating a core group of proteins involved in translation and ribosome assembly. While there are some secondary terms pointing to antibiotic response, stringent response, DNA repair, and transcription regulation, the strongest signal is the translation machinery, justifying the label.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0006415","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0017000","count":2}]},{"hash":"386488604716612556","title":"Developmental morphogenesis and signaling","description":"The cluster includes terms tied to organ and tissue development (cardiac ventricle morphogenesis, glomerular mesangial cell development), neural migration and axon guidance, cell\u2013cell adhesion, and regulatory signaling (NF-kappaB, stem cell differentiation, hyaluronan biosynthesis), suggesting a set of proteins involved in developmental processes and intercellular communication.","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":12},{"id":"GO:0055114","count":12},{"id":"GO:2000737","count":11},{"id":"GO:0090260","count":11},{"id":"GO:1900127","count":11}]},{"hash":"917587834971796848","title":"Developmental signaling and gene regulation","description":"This cluster is enriched for terms tied to development (forebrain and skeletal system development, multicellular growth) and transcriptional control (DNA-templated transcription, regulation of gene expression), with additional signals relating to GTPase activity and TGF-beta response. While there are also terms related to trafficking and immune defense, the strongest, coherent theme appears to be developmental regulation and signaling. ","confidence":"Medium","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0050830","count":7},{"id":"GO:0006890","count":6},{"id":"GO:0030900","count":6},{"id":"GO:0071560","count":5}]},{"hash":"909921942075827169","title":"Unknown","description":"The top terms are a mix of DNA processing, RNA splicing, and various developmental/regulatory processes, with no clear overarching function linking the proteins. The graph has no edges, further suggesting these proteins don\u2019t share a cohesive theme in this cluster. ","confidence":"","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032508","count":2},{"id":"GO:0015074","count":2},{"id":"GO:0006388","count":2},{"id":"GO:1900222","count":1},{"id":"GO:2001015","count":1}]},{"hash":"1373631247351704567","title":"Transcriptional regulation of the cell cycle","description":"This cluster combines strong signals for transcriptional control (negative regulation of RNA polymerase II transcription, DNA-templated transcription) with cell-cycle regulation (cell division, G1/S transition, CDK activity, regulation of the cell cycle). While there are some tissue/hormone-related terms (response to leptin, mammary gland alveolus development) that suggest context, the core theme appears to be coordinated transcriptional control linked to cell-cycle progression.","confidence":"High","size":28,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0051301","count":8},{"id":"GO:0045737","count":8},{"id":"GO:0000082","count":8},{"id":"GO:0071157","count":7}]},{"hash":"702093892468982864","title":"Mitochondrial Import and Oxidative Stress Response","description":"This cluster is dominated by terms for importing proteins into the mitochondrial matrix and maintaining redox balance, including cellular responses to oxidative stress and redox homeostasis, suggesting a core theme around mitochondrial protein handling and redox maintenance. Some DNA-templated transcription and replication terms and ER folding/ERAD-related terms appear as broader cellular stress or cross-organelle processes, but the primary signal points to mitochondria-associated import and redox regulation.","confidence":"Medium","size":28,"edges":378,"triangles":3276,"max_degree":27,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0030150","count":3},{"id":"GO:0034599","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1169565606336320578","title":"Neural Thermogenesis and Sensory Signaling","description":"This cluster is dominated by GO terms for pain perception, temperature stimulus response, and diet-induced thermogenesis, plus neuronal signaling components such as membrane potential regulation and dopamine receptor signaling. The combination points to a neural module involved in sensory processing, temperature regulation, and neuroendocrine signaling, with ancillary terms like visual learning and astrocyte chemotaxis supporting a CNS context.","confidence":"High","size":28,"edges":280,"triangles":1396,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":25},{"id":"GO:0002024","count":25},{"id":"GO:0071502","count":25},{"id":"GO:0042391","count":24},{"id":"GO:0040015","count":24}]},{"hash":"1980002563137361233","title":"TNF-Driven Extrinsic Apoptosis in Immune Cells","description":"The top GO terms center on extrinsic apoptotic signaling via death receptors and TNF-related processes (negative and positive regulation of extrinsic apoptosis, TNF production and response), with supporting signals from interferon pathways and T cell homeostasis. This suggests a functional module focused on TNF-mediated apoptosis regulation within immune contexts, with broader developmental immune roles (thymus development) and some context in reproductive immunology (decidualization). Overall, the cluster seems to reflect coordinated immune signaling that gates extrinsic apoptosis through TNF-related pathways.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":3},{"id":"GO:0032760","count":3},{"id":"GO:0043029","count":2},{"id":"GO:0019050","count":2},{"id":"GO:0060340","count":2}]},{"hash":"1125890275015433675","title":"Neuronal axon guidance and neural crest migration","description":"GO terms point to neural development and circuits: multiple entries refer to axon guidance (semaphorin-plexin signaling, branchiomotor neuron axon guidance) and nerve structure (trigeminal nerve organization, paranodal junctions, neural crest migration), with supportive roles in Rho signaling. Some terms (mast cell degranulation, sarcomere organization) appear incidental, but the dominant pattern is proteins involved in guiding neurites and forming nerve connections.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021637","count":4},{"id":"GO:1902287","count":4},{"id":"GO:0021785","count":4},{"id":"GO:0035023","count":3},{"id":"GO:0043303","count":3}]},{"hash":"506935443726912665","title":"Inner ear development and BMP-ERK signaling","description":"This cluster's terms are dominated by otic vesicle development and auditory sensory detection, with key BMP-responsive and ERK signaling terms suggesting a developmental program for inner ear morphogenesis. While other terms (heart, limb, skin morphogenesis) are present, the ear-related terms are most recurrent and cohesive, supporting a focus on inner ear development driven by BMP-ERK signaling.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0003007","count":2},{"id":"GO:0060174","count":2}]},{"hash":"1943539048306351707","title":"ECM Remodeling and Neural Connectivity","description":"The top terms cluster around collagen fibril organization and collagen biosynthetic processes, indicating extracellular matrix (ECM) remodeling. At the same time, neural development terms (axon extension, axonal fasciculation, synapse assembly) suggest ECM roles in guiding neural connectivity and cell adhesion; the complement term is less central. Overall, the cluster seems ECM-focused with a neural development angle.","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0032964","count":2},{"id":"GO:0006958","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0051965","count":2}]},{"hash":"1877284695031195711","title":"GPCR-driven Neuroimmune Signaling and Vascular Regulation","description":"The cluster\u2019s top terms converge on GPCR signaling (adenylate cyclase-activating pathways, serotonin receptor signaling), neurotransmitter dynamics (dopamine uptake), and vascular/neuroimmune contexts (blood pressure regulation, prostaglandin response, astrocyte chemotaxis, T cell differentiation). This suggests a theme of GPCR-mediated communication linking neural signaling with immune and vascular functions, with some metabolic energy context (electron transport chain) as a supportive background. ","confidence":"Medium","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045777","count":28},{"id":"GO:0010579","count":28},{"id":"GO:0022900","count":28},{"id":"GO:2000458","count":27},{"id":"GO:1901652","count":27}]},{"hash":"674536988946452790","title":"Neuronal Synaptic Signaling and Ion Channels","description":"The top GO terms cluster around neural communication and ion transport: excitatory postsynaptic potential, glutamatergic synaptic transmission, GABA signaling, and sodium/potassium transmembrane transport. The presence of behavior-related terms like conditioned taste aversion and locomotory behavior supports involvement in neural circuits governing learning and movement. Together these suggest a cohesive group of proteins underpinning synaptic signaling and ion channel activity.","confidence":"High","size":28,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0060079","count":9},{"id":"GO:0071805","count":8},{"id":"GO:0007214","count":8},{"id":"GO:0035725","count":8},{"id":"GO:0001661","count":8}]},{"hash":"708666948432450668","title":"Neural crest migration and axon guidance","description":"This cluster is dominated by terms about neural crest cell migration and neural wiring: ventral trunk neural crest migration, trigeminal nerve organization, branchiomotor neuron axon guidance, axonal fasciculation, and sympathetic neuron projection guidance, plus semaphorin-plexin signaling in axon guidance. A complement activation term is present but seems incidental; overall, the proteins group around neural development and axon pathfinding.","confidence":"High","size":28,"edges":58,"triangles":11,"max_degree":11,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006958","count":6},{"id":"GO:0036486","count":5},{"id":"GO:0021637","count":5},{"id":"GO:1902287","count":5},{"id":"GO:0007413","count":5}]},{"hash":"1708790099226614090","title":"Innate Immune Receptor Signaling & Complement Activation","description":"The most represented terms are immune-related, dominated by complement activation via the lectin pathway, C-type lectin receptor signaling, and Fc-gamma receptor signaling, plus response to fungal origin. This strongly suggests a core theme of innate immune recognition and signaling. While there are outlier terms related to development and cartilage, the dominant pattern is innate immune receptor activity and complement pathways, supporting this label.","confidence":"High","size":27,"edges":17,"triangles":5,"max_degree":4,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":18},{"id":"GO:0001867","count":14},{"id":"GO:0010572","count":13},{"id":"GO:0001502","count":13},{"id":"GO:0060355","count":12}]},{"hash":"1025820402494425144","title":"Neurovascular signaling and coagulation regulation","description":"This cluster\u2019s top GO terms span both neural function (positive regulation of glutamatergic synaptic transmission) and vascular/coagulation processes (blood coagulation, fibrin clot formation; negative regulation of angiogenesis; fibrinolysis; endothelial cell survival). The presence of cell surface localization and adhesion terms, along with pattern recognition receptor signaling, suggests membrane-associated regulators that coordinate signaling at the neurovascular interface. Together, these indicate a theme of extracellular signaling proteins modulating both neuronal activity and vascular remodeling or maintenance, justifying the label even though multiple domains are represented.","confidence":"Medium","size":27,"edges":5,"triangles":0,"max_degree":2,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0051968","count":7},{"id":"GO:0072378","count":7},{"id":"GO:0034394","count":6},{"id":"GO:0016525","count":6},{"id":"GO:0042730","count":6}]},{"hash":"1455856209538458158","title":"Angiogenesis and Endothelial Migration Regulation","description":"The top GO terms point to vascular biology, with strong representation for positive regulation of angiogenesis, endothelial cell migration, and blood vessel development, plus related signaling and hemostasis processes\u2014together suggesting a cluster of proteins involved in blood vessel formation and remodeling.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0045766","count":6},{"id":"GO:0070374","count":6},{"id":"GO:0090331","count":6},{"id":"GO:0043536","count":6},{"id":"GO:0002752","count":5}]},{"hash":"249612438799338225","title":"Neuronal adhesion and axon guidance","description":"The cluster is dominated by GO terms for cell\u2013cell adhesion (heterophilic and homophilic) and several neuron-specific processes, including axon guidance (sympathetic and branchiomotor neurons), paranodal junction assembly, and juxtaparanode localization, indicating a cohesive role in neuron connectivity and myelinated fiber organization. Some terms like ossification appear less central and may reflect broader or multifunctional proteins, but the neural themes are strong.","confidence":"Medium","size":27,"edges":282,"triangles":1626,"max_degree":25,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0043031","count":7},{"id":"GO:0043931","count":7},{"id":"GO:0007156","count":7},{"id":"GO:1905065","count":7}]},{"hash":"45099424154272757","title":"Inflammation and proteostasis signaling","description":"The cluster includes GO terms tied to inflammatory pathways (TNF signaling, canonical NF-kappaB activation), and proteostasis processes (ubiquitin regulation, ERAD, protein ubiquitination), plus cytoskeletal and mitochondrial dynamics (actin crosslinking, GTPase activity, mitochondrial fusion). This combination suggests a shared theme of stress-response signaling that integrates immune signaling with protein quality control and cellular remodeling.","confidence":"Medium","size":27,"edges":315,"triangles":2151,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0035774","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0043123","count":3},{"id":"GO:0046597","count":3},{"id":"GO:0033209","count":3}]},{"hash":"1880628265673881409","title":"Plant cell wall glycoprotein biosynthesis","description":"This cluster is dominated by GO terms for arabinogalactan protein metabolism, hydroxyproline O-glycosylation, and mucilage/seed coat biosynthesis, along with root hair development and cell adhesion, pointing to plant extracellular glycoproteins that shape cell wall properties and development. A few insect-related terms are present but do not outweigh the clear plant glycosylation/AGP signal, so the label reflects glycosylation-dependent cell surface components in plants.","confidence":"Medium","size":27,"edges":278,"triangles":1583,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0001744","count":4},{"id":"GO:0042248","count":4},{"id":"GO:0010405","count":4},{"id":"GO:0007299","count":4},{"id":"GO:0030311","count":4}]},{"hash":"1631116951418988256","title":"Interferon-driven innate antiviral response","description":"These proteins cluster around innate immune signaling and antiviral defenses. Key terms include cellular response to type I interferon, innate immune response, response to dsRNA, and antiviral defense regulation, indicating a core interferon-mediated antiviral program. Some terms like response to morphine or photoreceptor localization appear peripheral, but the dominant theme is interferon signaling and antiviral defense.","confidence":"High","size":27,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043278","count":14},{"id":"GO:0051301","count":14},{"id":"GO:0045087","count":14},{"id":"GO:0071357","count":14},{"id":"GO:0050689","count":14}]},{"hash":"10208893800401693","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by ribosome/translation-related GO terms: cytoplasmic translation, ribosomal large subunit export from nucleus, and tRNA modification, which point to protein synthesis machinery and ribosome biogenesis as the core theme. Other terms touch on cell cycle and division, suggesting coupling of growth and proliferation, while some terms (potassium transport, GABAergic signaling) appear less connected to the main theme. This combination supports a translation/ ribosome-focused cluster with some ancillary processes. ","confidence":"Medium","size":27,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0002181","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0007049","count":2}]},{"hash":"1944407201093256762","title":"DNA replication and cell cycle cluster","description":"Most frequent GO terms are DNA biosynthetic process, DNA replication, and G1/S transition of mitotic cell cycle, pointing to a core association with DNA synthesis and cell cycle control. A few other terms (cell morphogenesis, lipid A biosynthetic process, T cell homeostasis, and responses to cocaine/morphine) appear as secondary annotations and do not strongly unify the cluster, suggesting a main theme of replication and proliferation with mixed secondary signals.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071897","count":2},{"id":"GO:0070940","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0000902","count":2},{"id":"GO:0009245","count":2}]},{"hash":"861832271387259310","title":"Neuro-immune development","description":"This cluster shows neural development signals (axonogenesis involved in innervation; myelination in peripheral nervous system) together with innate immune processes (innate immune response; opsonization; response to yeast; regulation of macrophage-related functions and ROS generation). The combination hints at neuro-immune interactions or concurrent neural development and immune signaling, justifying the label, though the connection is not uniformly strong across terms.","confidence":"Medium","size":27,"edges":22,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":4},{"id":"GO:0010745","count":4},{"id":"GO:0044869","count":3},{"id":"GO:0008228","count":3},{"id":"GO:0010888","count":3}]},{"hash":"82610944229465296","title":"Chromatin silencing and transcription regulation","description":"The terms center on chromatin organization, heterochromatin formation, histone modification control, and repression of RNA Pol II transcription, with related processes like rDNA heterochromatin and dosage compensation. This points to a cohesive role in establishing/maintaining repressive chromatin states and transcriptional control. ","confidence":"High","size":27,"edges":235,"triangles":1132,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0071169","count":15},{"id":"GO:0030466","count":15},{"id":"GO:0000122","count":14},{"id":"GO:0006335","count":14},{"id":"GO:0051572","count":14}]},{"hash":"1371527413847621376","title":"RNA Transcription and RNA Modification","description":"The terms cluster around DNA-templated transcription, mRNA capping, multiple RNA methylation activities (mRNA, tRNA, rRNA), mRNA export, and regulation of translation initiation, indicating proteins involved in transcription and post-transcriptional RNA processing/modification, including methyltransferases.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0006370","count":3},{"id":"GO:0036265","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0006446","count":3}]},{"hash":"526333812166879106","title":"Developmental growth and transcriptional machinery","description":"The Top Terms cluster around organismal development (skin, brain, multicellular growth) and core gene-expression processes (DNA-templated transcription, mRNA splicing, ribosome biogenesis) plus growth signaling (TORC1). This suggests a theme of development and the machinery that drives growth and transcription, even though the proteins may not form a connected interaction network in this set. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0070208","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0050731","count":3}]},{"hash":"253110403064713266","title":"Antioxidant defense and inflammatory signaling","description":"The cluster centers on redox/homeostatic processes (cellular oxidant detoxification; glutathione metabolism/derivatives) while also including inflammatory signaling regulation (negative regulation of TNF and IL-1\u03b2, prostaglandin biosynthesis) and platelet/adhesion-related responses, suggesting coordinated antioxidant protection alongside modulation of inflammatory and hemostatic pathways.","confidence":"Medium","size":27,"edges":328,"triangles":2432,"max_degree":26,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":14},{"id":"GO:0070527","count":12},{"id":"GO:0001516","count":12},{"id":"GO:0045471","count":10},{"id":"GO:0070373","count":10}]},{"hash":"480014839907544382","title":"Neuronal adhesion and paranodal junction assembly","description":"This cluster is dominated by GO terms for heterophilic cell-cell adhesion, paranodal and juxtaparanodal localization, and positive regulation of synapse assembly, plus proteins localized to the paranode region of the axon. Together these terms suggest a module of proteins that mediate neuronal cell adhesion and the assembly/organization of paranodal and juxtaparanodal axonal junctions, consistent with node-of-Ranvier\u2013type architecture. Some terms seem less directly related (e.g., symbiont entry, NF-kappaB regulation) and may reflect broader signaling roles or annotation noise, but the core theme is clear: neuronal adhesion and paranodal junction formation.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007157","count":8},{"id":"GO:0030913","count":7},{"id":"GO:0051965","count":7},{"id":"GO:0002175","count":7},{"id":"GO:0071205","count":7}]},{"hash":"1039531291418711744","title":"Neural development and synapse formation","description":"Strong enrichment for nervous system development, synapse assembly/organization, retina morphogenesis, and ROBO signaling indicates a module focused on neural development and connectivity; other terms reflect broader developmental programs but do not override the neural theme.","confidence":"High","size":27,"edges":279,"triangles":1627,"max_degree":26,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007399","count":24},{"id":"GO:0035385","count":23},{"id":"GO:0051965","count":23},{"id":"GO:0007507","count":23},{"id":"GO:0050808","count":22}]},{"hash":"885577955085293554","title":"Inflammation, vascular response, and coagulation","description":"The cluster is dominated by GO terms for inflammatory processes (inflammatory response, response to lipopolysaccharide) and nociception (sensory perception of pain), alongside vascular and coagulation-related terms (positive regulation of vasoconstriction, blood coagulation, plasminogen activation, smooth muscle regulation). This points to a coordinated inflammatory program with vascular tone changes and coagulation activity; the hair cycle term may reflect skin/tissue context rather than a separate function. Therefore, a label highlighting inflammation with vascular and coagulation involvement is appropriate.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":12},{"id":"GO:0045907","count":12},{"id":"GO:0019233","count":11},{"id":"GO:0032496","count":11},{"id":"GO:0007596","count":11}]},{"hash":"2276834346514158052","title":"mRNA processing and export","description":"These proteins show a coherent emphasis on RNA metabolism, with GO terms for mRNA export from the nucleus, mRNA stabilization, and regulation of poly(A) tail length and polyadenylation. There are also terms related to subunit processome assembly and regulatory ncRNA-mediated gene silencing, plus some obsolete annotations. The dominant theme is nuclear mRNA maturation and handling, suggesting a cluster of factors involved in processing, modification, and export of mRNA rather than a specific signaling pathway. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902625","count":1},{"id":"GO:0034462","count":1},{"id":"GO:1901407","count":1},{"id":"GO:0006406","count":1},{"id":"GO:0031047","count":1}]},{"hash":"1376130986039682350","title":"Ribosome biogenesis and translation (mitochondrial)","description":"The top GO terms are dominated by translation (cytoplasmic and general) and ribosome biogenesis, including ribosomal large subunit assembly and rRNA processing, which points to a core function in protein synthesis and ribosome assembly. The presence of a term for protein insertion into the mitochondrial inner membrane from the matrix aligns with mitochondrial protein import/assembly, suggesting a link between cytosolic/mitochondrial translation machinery. Some metabolic terms (acetylcholine biosynthesis and fatty acid metabolism) are present but appear less central to the cluster\u2019s primary signal, which is focused on gene-expression machinery and mitochondrial protein handling.","confidence":"Medium","size":27,"edges":24,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0032979","count":2},{"id":"GO:0006364","count":2},{"id":"GO:0006351","count":2}]},{"hash":"422555868820539996","title":"Unknown","description":"The GO terms are highly diverse (lipopolysaccharide metabolism, unfolded protein response, photoreceptor localization, cell division, centrosome maintenance, plant hormone signaling, ER-associated ubiquitin processes, metal ion response, acetylation, and left-right asymmetry), with no clear single function tying the cluster together. Therefore, a cohesive, specific label is not supported.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0008653","count":5},{"id":"GO:0006986","count":5},{"id":"GO:1903546","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0051661","count":5}]},{"hash":"1025126867972111493","title":"TLR/MyD88-NLRP3 Innate Immune Signaling","description":"This cluster is defined by GO terms tied to bacterial component sensing and inflammatory signaling, including MyD88-dependent TLR signaling, NF-kappaB activation, detection of LPS and lipoteichoic acid, IL-1\u03b2 production, and NLRP3 inflammasome assembly. Together these terms point to a cohesive innate immune response module to bacterial pathogens, combining pattern recognition receptors (TLRs) with inflammasome-driven cytokine production.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032094","count":2},{"id":"GO:0071222","count":2},{"id":"GO:0050702","count":2},{"id":"GO:0032497","count":2},{"id":"GO:0050830","count":2}]},{"hash":"1356699073020109018","title":"Inflammation and vascular signaling","description":"The cluster centers on inflammatory processes (inflammatory response, response to LPS) and prostaglandin-related signaling, plus regulation of vasoconstriction and macrophage chemotaxis, suggesting a common theme of immune-driven inflammation and vascular tone modulation; dopaminergic signaling and sensory perception terms may reflect broader neural signaling contexts linked to these pathways.","confidence":"High","size":27,"edges":25,"triangles":0,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":4},{"id":"GO:0007601","count":4},{"id":"GO:0071380","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0006954","count":3}]},{"hash":"855638849758658365","title":"Carbohydrate and lipid biosynthesis","description":"Top GO terms indicate biosynthetic processes for glycogen, sucrose, glycolipids, and phospholipids, pointing to a shared role in constructing carbohydrate- and lipid-based molecules. The inclusion of bacillithiol biosynthetic process supports a bacterial/metabolic biosynthesis theme, while other terms like response to flooding or feeding behavior appear as broader contextual associations rather than core functions. Overall, the cluster seems best described as carbohydrate- and lipid-biosynthesis proteins rather than a single specific pathway.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":7},{"id":"GO:0009247","count":7},{"id":"GO:0097502","count":7},{"id":"GO:0008654","count":7},{"id":"GO:0009405","count":7}]},{"hash":"1640909138176842339","title":"FGF-MAPK signaling in organ development","description":"The cluster is dominated by GO terms linking FGFR signaling to the MAPK/ERK cascade (ERK1/ERK2, MAPKKK) and to development across multiple organs (nervous system, kidney, lung, angiogenesis). Endothelial chemotaxis to FGFs and regulation of Rho signaling further point to coordinated growth, morphogenesis, and vascular formation. This suggests a cohesive theme: growth factor\u2013driven MAPK signaling guiding organogenesis and vascular development.","confidence":"High","size":27,"edges":76,"triangles":24,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0007275","count":7},{"id":"GO:0007399","count":7},{"id":"GO:0060484","count":6},{"id":"GO:0035023","count":6}]},{"hash":"1813974569170928732","title":"Dopamine GPCR Signaling","description":"Most of the top GO terms point to dopaminergic GPCR signaling and related neuronal communication, including dopamine receptor\u2013activated adenylate cyclase, regulation of dopamine uptake, and downstream GPCR effects such as GTPase activity and prostaglandin responsiveness. While a few terms (e.g., renin secretion) are less related, the dominant theme across the terms strongly supports a dopaminergic GPCR\u2013mediated signaling cluster.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":26},{"id":"GO:1900135","count":26},{"id":"GO:2000458","count":26},{"id":"GO:1901652","count":26},{"id":"GO:0018298","count":26}]},{"hash":"945623434833247876","title":"Steroid Hormone Signaling and Reproductive Development","description":"This cluster is dominated by GO terms tied to hormone/nuclear receptor signaling (estradiol response, androgen receptor signaling, glucocorticoid signaling) and female reproductive development (female gonad development, trophoblast differentiation, BMP signaling regulation). While pigmentation and circadian regulation appear as ancillary terms, the common thread is regulation of steroid receptor pathways and female reproductive maturation. Confidence reflects a coherent hormonal-development theme, though the diverse terms warrant a cautious, medium confidence.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050766","count":2},{"id":"GO:0071392","count":2},{"id":"GO:0043473","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0060766","count":2}]},{"hash":"195779209016909028","title":"Unknown","description":"The top GO terms describe a broad mix of functions (DNA-templated transcription, innate immune response, bone and ventricle development, mitotic cell cycle, GTPase regulation) and even some obsolete terms, with no single cohesive biological theme. The absence of edges/triangles and the diverse, seemingly unrelated processes suggest this cluster does not map to a specific, shared function. Therefore no confident, representative label can be assigned.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0045087","count":3},{"id":"GO:0060348","count":3},{"id":"GO:0043547","count":3}]},{"hash":"1717368752271998241","title":"Developmental differentiation and cell adhesion","description":"The proteins in this cluster are linked to multiple developmental and tissue-specific processes, including cell adhesion and development of brain, lens, skeletal, and skin tissues, as well as neuron projection development. The spread across mitotic cell cycle and tissue-specific development terms suggests a role in broad developmental programs rather than a single pathway, hence this label.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":3},{"id":"GO:0051301","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0070306","count":2}]},{"hash":"386669398847919177","title":"GPCR signaling in cardiovascular and neuroendocrine pathways","description":"The cluster is dominated by GO terms for adenylate cyclase-activating GPCR signaling and dopamine receptor signaling, with related terms tied to prostaglandin response, renin secretion, blood pressure regulation, and peptide response. This points to GPCR-driven signaling that coordinates cardiovascular and neuroendocrine functions. An outlier term (electron transport chain) may reflect incidental mitochondrial associations rather than core function. Overall, the proteins appear to function as a GPCR-mediated signaling module affecting cardiovascular and neuroendocrine processes.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0007191","count":25},{"id":"GO:1900135","count":25}]},{"hash":"687185195158081182","title":"Cardiovascular GPCR signaling and blood pressure regulation","description":"This cluster is dominated by GO terms for G protein-coupled receptor signaling that activates adenylate cyclase (e.g., dopamine receptor signaling, prostaglandin responses) and regulates blood pressure and renin secretion, suggesting a cohesive cardiovascular signaling theme, with a note of concurrent metabolic context from the electron transport chain term.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":26},{"id":"GO:0022900","count":26},{"id":"GO:0045777","count":26},{"id":"GO:0007191","count":25},{"id":"GO:1900135","count":25}]},{"hash":"1042087402023187606","title":"Cardiac Electrophysiology and Thermo-Sensory Signaling","description":"GO terms center on membrane potential changes in cardiac cells (depolarization/repolarization), cardiac conduction, and hypertrophy in response to stress, with additional associations to temperature stimulus and pain perception. This points to proteins involved in cellular excitability and stress responses across cardiac and neural contexts, justifying a label focused on cardiac electrophysiology while acknowledging thermo- and nociceptive signaling. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":14},{"id":"GO:0019233","count":13},{"id":"GO:0060081","count":13},{"id":"GO:0043931","count":13},{"id":"GO:0002024","count":12}]},{"hash":"441230194883083011","title":"Neurovascular development","description":"The top terms cluster around neural development (neuron migration, axonal fasciculation, synapse assembly) and cell adhesion, with angiogenesis and heart development suggesting concurrent vascular/cardiac development. Although some immune signaling terms appear, the dominant theme ties neural wiring with vascular/heart formation and adhesion. ","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0001764","count":6},{"id":"GO:0051965","count":6},{"id":"GO:0043031","count":6},{"id":"GO:0007156","count":6},{"id":"GO:0001525","count":6}]},{"hash":"1868718084057192571","title":"Unknown","description":"The top terms cover diverse processes including ribosome biogenesis (rRNA maturation, nonfunctional rRNA decay), protein ubiquitination and ERAD-related pathways, mitotic spindle orientation, peroxisome matrix import, microtubule severing, and histone modifications. The lack of a single unifying function and the presence of obsolete GO terms, plus no interactions among proteins, suggest there isn\u2019t a coherent shared function to label this cluster with a specific, representative name.","confidence":"","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000466","count":3},{"id":"GO:0030433","count":3},{"id":"GO:0070651","count":2},{"id":"GO:0000132","count":2},{"id":"GO:0016558","count":2}]},{"hash":"120389566000565806","title":"Neural development and tissue morphogenesis","description":"The terms cluster around broad developmental processes (kidney, skin, cartilage development; multicellular organism development) alongside neural connectivity events (axonal fasciculation, neuron migration, synapse assembly) and cell adhesion, suggesting a developmental program that spans tissues with emphasis on neural wiring.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0001502","count":2},{"id":"GO:0035360","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007275","count":2}]},{"hash":"1791244122136527840","title":"Diverse signaling and growth responses","description":"The cluster includes GO terms covering cellular responses to growth factors (TGF-beta, growth hormone), signaling pathways (SREBP), and retrograde signaling (mitochondria-nucleus), plus regulation of GTPase activity and tissue-specific developmental/apoptotic processes. This suggests a broad theme of signaling and growth-related responses across different tissues rather than a single cohesive function.","confidence":"Medium","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010659","count":1},{"id":"GO:0070306","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0034349","count":1}]},{"hash":"1486710435337423529","title":"Skeletal System Development and ECM Remodeling","description":"This cluster centers on bone formation and remodeling (osteoblast differentiation, osteoclast regulation) and broader extracellular matrix (ECM) dynamics, including plasminogen activation, elastic fiber assembly, and aorta/connective tissue development. The dominant GO terms point to coordinated skeletal development and ECM remodeling in connective tissues.","confidence":"High","size":27,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010226","count":3},{"id":"GO:2001205","count":2},{"id":"GO:1900025","count":2},{"id":"GO:0090091","count":2},{"id":"GO:0010756","count":2}]},{"hash":"1480283139973982678","title":"Cerebellar Purkinje neuron structure and plasticity","description":"The cluster includes terms tied to cerebellar Purkinje cell layer organization and to positive regulation of synaptic plasticity, suggesting a focus on Purkinje neuron structure and function in the cerebellum. While there are also terms related to transcription and ubiquitination, the clearest shared theme is neuronal development/maintenance and synaptic adaptability in Purkinje neurons.","confidence":"Medium","size":26,"edges":25,"triangles":3,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0021693","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0055114","count":2},{"id":"GO:2001162","count":2}]},{"hash":"464006302314802863","title":"Developmental transcription and signaling cluster","description":"The top GO terms center on DNA-templated transcription and organ development (heart, brain/forebrain, multicellular development), with additional hints of signaling regulation (GTPase activity, Wnt, integrin signaling, T cell receptor signaling) and innate immunity. This suggests a group of proteins coordinating development through various signaling pathways, rather than a tissue- or process-specific module.","confidence":"High","size":26,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0007420","count":5}]},{"hash":"935191840919174668","title":"Ribosome Biogenesis and RNA Processing","description":"Cluster terms strongly center on ribosomal RNA maturation and ribosomal subunit biogenesis (SSU/LSU rRNA maturation, 5.8S rRNA maturation, large subunit biogenesis) and also include mRNA splicing via the spliceosome and regulatory ncRNA-mediated gene silencing, indicating a core function in RNA biogenesis and processing. A peripheral cell-cycle term is present but does not redefine the main theme. Confidence in this labeling is High.","confidence":"","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0000462","count":5},{"id":"GO:0042273","count":5},{"id":"GO:0006369","count":5},{"id":"GO:0045292","count":5},{"id":"GO:0031047","count":4}]},{"hash":"264834174252227271","title":"ABA-Responsive Osmotic Stress Signaling","description":"This cluster is dominated by GO terms tied to abscisic acid (ABA) signaling and osmotic stress responses (ABA-activated signaling pathway, hyperosmotic salinity response), with supporting hints from signaling-related processes such as protein dephosphorylation and phospholipid/inositol biosynthesis that are common in membrane signaling cascades under stress. Other metabolic terms (gluconeogenesis, sulfate and inositol biosynthesis) suggest broader metabolic remodeling accompanying ABA-mediated stress adaptation. Overall, the set appears to reflect ABA-driven stress signaling and associated metabolic adjustments.","confidence":"High","size":26,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0009738","count":4},{"id":"GO:0006470","count":3},{"id":"GO:0000103","count":2},{"id":"GO:0006094","count":2},{"id":"GO:0046855","count":2}]},{"hash":"2224739217173620722","title":"Neural development signaling and axon guidance","description":"The top GO terms emphasize neural development and signaling, including positive regulation of the ERK1/ERK2 cascade, axon guidance, nervous system development, and dopamine uptake in synaptic transmission. Although some terms relate to organ morphogenesis (kidney, lung), the dominant theme across the cluster is neural development and associated signaling pathways that govern neuron growth and synaptic activity.","confidence":"Medium","size":26,"edges":26,"triangles":1,"max_degree":25,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0070374","count":8},{"id":"GO:0043552","count":5},{"id":"GO:0010513","count":5},{"id":"GO:0007411","count":5},{"id":"GO:0001822","count":5}]},{"hash":"893353833783807779","title":"Spliceosome-mediated mRNA processing and splicing regulation","description":"The cluster is dominated by GO terms related to mRNA splicing via the spliceosome (including alternative splicing), regulatory aspects of splicing, and mRNA processing/stability, with additional links to transcription termination and small-subunit processome assembly. This points to a cohesive theme of RNA processing machinery and splicing regulation.","confidence":"High","size":26,"edges":314,"triangles":2360,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":6},{"id":"GO:0045292","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0010610","count":5},{"id":"GO:0000380","count":5}]},{"hash":"981381412881237299","title":"Drosophila follicle epithelium development and polarity","description":"Top GO terms indicate ovarian follicle epithelium development with emphasis on polarity maintenance and cell adhesion in the egg chamber, plus related epidermal/corneocyte differentiation; this provides a coherent theme for the cluster despite some auxiliary terms.","confidence":"Medium","size":26,"edges":7,"triangles":0,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0075015","count":9},{"id":"GO:0001744","count":6},{"id":"GO:0042248","count":6},{"id":"GO:0007299","count":6},{"id":"GO:2000466","count":5}]},{"hash":"1725187523088350623","title":"Carbohydrate biosynthesis and sugar response","description":"The cluster is dominated by GO terms tied to carbohydrate metabolism and sugar-related responses, including glycogen, starch, sucrose, and glycolipid biosynthesis, as well as responses to sugars and osmotic/feeding-related cues. This suggests a cohesive theme around carbohydrate production and sugar signaling/stress, with some noisy terms (e.g., bacillithiol biosynthesis, feeding behavior) that are less central to the core theme. ","confidence":"Medium","size":26,"edges":57,"triangles":35,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0009413","count":5},{"id":"GO:0005978","count":5},{"id":"GO:0009247","count":5},{"id":"GO:0072708","count":5},{"id":"GO:0071793","count":5}]},{"hash":"1828736031481376450","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":324,"triangles":2576,"max_degree":25,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":20},{"id":"GO:0048026","count":20},{"id":"GO:0000464","count":16},{"id":"GO:0042273","count":15},{"id":"GO:0000716","count":15}]},{"hash":"455552381475274371","title":"Mammary Gland Proteoglycan Biosynthesis and Remodeling","description":"This cluster centers on biosynthesis of chondroitin sulfate and dermatan sulfate proteoglycans, key ECM components, with additional signals related to lactation (lactose biosynthetic process) and mammary gland remodeling (epithelial proliferation in wound healing, involution-related apoptotic regulation, and fibroblast proliferation modulation). The combination suggests coordinated production of ECM proteoglycans and tissue remodeling in the mammary gland.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009405","count":7},{"id":"GO:0006486","count":7},{"id":"GO:0075015","count":6},{"id":"GO:0050650","count":6},{"id":"GO:0050651","count":6}]},{"hash":"1688737466926716115","title":"Neural crest\u2013driven craniofacial and muscle development","description":"This cluster is strongly enriched for terms tied to neural crest derivatives and craniofacial/muscle formation, including cardiac neural crest migration, branchiomeric skeletal muscle development, and carotid body glomus cell differentiation, plus vestibular nucleus development. The presence of transcriptional regulation terms (transcription by RNA polymerase II) and hormone-responsive regulation (estradiol stimulus) fits with developmental gene expression control. Together, these points suggest a coherent theme around neural crest\u2013driven development of craniofacial structures and muscles.","confidence":"High","size":26,"edges":325,"triangles":2600,"max_degree":25,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":22},{"id":"GO:0071392","count":21},{"id":"GO:0048712","count":21},{"id":"GO:2001038","count":21},{"id":"GO:0003253","count":20}]},{"hash":"2174555765110443282","title":"Unknown","description":"The GO terms cover skin and skeletal development, protein heterotrimerization, Golgi-to-ER transport, ERAD, transcription, chromatin modification, synaptic plasticity, cell division and mitotic chromatid segregation, with no obvious shared function among all 26 proteins. Edges and interactions are zero, suggesting a heterogeneous collection rather than a cohesive pathway. Because there isn't a clear common theme, a single, accurate label is not evident.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":3},{"id":"GO:0070208","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0006890","count":2},{"id":"GO:0030433","count":2}]},{"hash":"1134297533747308670","title":"Transmembrane Transport of Metabolites and Ions","description":"The cluster is dominated by GO terms for transmembrane transport of various small molecules and ions, including vitamins, xenobiotics, potassium, nitrate, phosphate, urate, and selenite. This points to a cohesive group of membrane transporter proteins facilitating uptake or efflux of diverse substrates. The outlier term related to replicative senescence is likely incidental. Overall, the common theme is membrane transport activity across substrates.","confidence":"High","size":26,"edges":271,"triangles":1521,"max_degree":25,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":26},{"id":"GO:0006855","count":26},{"id":"GO:0071805","count":22},{"id":"GO:0042908","count":22},{"id":"GO:0042891","count":20}]},{"hash":"453648140203106516","title":"Neurovascular signaling regulators","description":"This cluster is enriched for neural and cardiovascular signaling terms, including regulation of dopamine secretion, GABAergic synaptic transmission, heart development, calcium release into cytosol, and vasoconstriction, suggesting proteins that coordinate neurovascular signaling and calcium-mediated pathways. While defense and mucus-related terms appear, the core theme centers on neurovascular communication and signaling regulation.","confidence":"Medium","size":26,"edges":17,"triangles":0,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007507","count":7},{"id":"GO:0043547","count":6},{"id":"GO:0051209","count":6},{"id":"GO:0014059","count":5},{"id":"GO:0070257","count":5}]},{"hash":"1875256212986827649","title":"Neurodevelopmental signaling and cell adhesion","description":"This cluster centers on developmental signaling and cell interactions, with terms like negative regulation of Notch signaling, dopaminergic neuron axon guidance, GPCR acetylcholine signaling, planar polarity and homophilic cell-cell adhesion. Receptor clustering and morphogenesis-related terms (lung branching) suggest broader developmental context beyond strictly neural processes. Overall, the proteins seem tied to signaling-modulated development and cell adhesion.","confidence":"Medium","size":26,"edges":24,"triangles":0,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":10},{"id":"GO:0055114","count":9},{"id":"GO:0043113","count":9},{"id":"GO:0036514","count":9},{"id":"GO:0060489","count":9}]},{"hash":"1421360802827120133","title":"Type I IFN\u2013mediated antiviral response","description":"Based on the Top Terms, the cluster is enriched for innate immune activities and interferon responses, including cellular response to type I interferon and dsRNA, as well as antiviral defense regulation. While a few terms (photoreceptor localization, histone methylation, and male differentiation) are less aligned with antiviral immunity, the dominant theme centers on interferon-driven antiviral signaling.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0050689","count":6},{"id":"GO:0051301","count":6},{"id":"GO:0071357","count":6},{"id":"GO:0071360","count":6}]},{"hash":"916942048812678912","title":"DNA Damage Response and Checkpoint Signaling","description":"The cluster is enriched for DNA damage checkpoint signaling, DNA repair, replication and intra-S checkpoints, and telomere maintenance via telomerase, suggesting a cohesive role in genome integrity maintenance; a few terms like translation and leukocyte migration appear less central.","confidence":"High","size":26,"edges":32,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0050900","count":2},{"id":"GO:0032212","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0000077","count":2},{"id":"GO:0007131","count":2}]},{"hash":"2198888768228762758","title":"Blood coagulation and plasminogen activation (fibrinolysis)","description":"The top terms cluster around coagulation, plasminogen activation, and fibrinolysis, with supportive terms for regulation of coagulation and fibrinogen, plus an inflammatory signal (LPS response) suggesting hemostasis and clot remodeling in an inflammatory context.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0051919","count":8},{"id":"GO:0031639","count":8},{"id":"GO:0030194","count":7},{"id":"GO:0032496","count":7}]},{"hash":"946214579329635813","title":"Neural development and synapse formation","description":"The cluster is enriched for neural connectivity terms: axon guidance (retinal ganglion, optic nerve), brain structure development (corpus callosum), dendritic spine morphogenesis, and trans-synaptic signaling/synapse assembly, with integrin-mediated adhesion regulation supporting neuronal adhesion; two immune terms are present but secondary.","confidence":"High","size":26,"edges":21,"triangles":2,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":2},{"id":"GO:0048320","count":2},{"id":"GO:0031290","count":2},{"id":"GO:0021631","count":2},{"id":"GO:0033628","count":2}]},{"hash":"1538388589754802627","title":"Dopaminergic Visual Reward Signaling","description":"This cluster is dominated by neural signaling and perception terms: dopaminergic synaptic transmission, visual perception and learning, behavioral response to cocaine, and ERK1/ERK2 cascade, pointing to dopamine-driven sensory processing and reward pathways. Regulation of membrane potential supports neuronal excitability. Some terms like heart development and macrophage chemotaxis appear tangential and may reflect multifunctional proteins, but the core theme remains neural signaling. ","confidence":"Medium","size":26,"edges":270,"triangles":1524,"max_degree":25,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":21},{"id":"GO:0007507","count":21},{"id":"GO:0071380","count":20},{"id":"GO:0010759","count":20},{"id":"GO:0001963","count":20}]},{"hash":"1566998012529404063","title":"Neuronal development and synaptic signaling regulators","description":"The cluster shows enrichment across neuronal and synaptic contexts: brain development, regulation of synaptic vesicle exocytosis, ERK signaling, GTPase activity, and phosphatidylinositol signaling, with involvement of Wnt pathways. Taken together, these terms point to proteins that modulate signaling cascades during neurodevelopment and synapse function, rather than a single linear pathway.","confidence":"Medium","size":26,"edges":49,"triangles":3,"max_degree":7,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0070374","count":5},{"id":"GO:0031532","count":5},{"id":"GO:0048015","count":5},{"id":"GO:0031384","count":5}]},{"hash":"107626788214950874","title":"Eye and endothelial morphogenesis proteins","description":"The GO terms show emphasis on developmental processes, especially eye development (camera-type eye development) and endothelial morphogenesis, suggesting a cluster of proteins involved in vascular and ocular development. Additional, weaker signals for immune defense and protein regulation exist but are not dominant; thus the label centers on the clearest shared role in eye/vasculature formation.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:0001886","count":2},{"id":"GO:0002230","count":1},{"id":"GO:0032464","count":1},{"id":"GO:0090141","count":1}]},{"hash":"1172501151415841491","title":"Cardiovascular Development and PNS Myelination","description":"The top GO terms are dominated by heart development, branching of blood vessels, and cardiac muscle contraction, pointing to a cardiovascular development/function theme. There are also signals related to prostaglandin response and innate immune activity, which can accompany vascular remodeling, plus an annotation for peripheral nervous system myelination, suggesting some proteins in this cluster may link cardiovascular development with neural maturation or innervation. Overall, the cluster appears centered on cardiovascular developmental processes with a peripheral nervous system component, justifying this label. ","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":2},{"id":"GO:0001569","count":2},{"id":"GO:0022011","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0060048","count":2}]},{"hash":"1579287013780359213","title":"Unknown","description":"The GO terms span a wide range of processes (innate mucosal immunity, bone remodeling, retina maintenance, metal ion transport, and general transcription factor regulation), with no clear, single shared function tying the proteins together. The lack of edges and the diversity suggest this is a mixed cluster rather than a coherent functional module.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010756","count":2},{"id":"GO:0045071","count":1},{"id":"GO:0051092","count":1},{"id":"GO:2001205","count":1},{"id":"GO:0002227","count":1}]},{"hash":"523951975570303984","title":"Axon Guidance and Dendritic Spine Development","description":"The top GO terms point to neuronal development and morphogenesis, including ROBO-mediated axon guidance, dendritic spine maturation, and filopodium/cytoskeletal assembly, with supporting roles for endosome localization and JNK signaling. Immune-related terms appear but are secondary to neuronal guidance and synaptic remodeling.","confidence":"High","size":26,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903232","count":3},{"id":"GO:0046330","count":3},{"id":"GO:0007411","count":3},{"id":"GO:0042088","count":3},{"id":"GO:0002551","count":3}]},{"hash":"1959872739401562558","title":"Dopaminergic Pain Perception and Sensorimotor Processing","description":"The cluster is dominated by GO terms related to pain and sensory perception, dopaminergic signaling, and modulation of glutamatergic transmission, along with behavioral facets like prepulse inhibition and visual learning, suggesting a coherent theme of dopamine-regulated sensory/pain processing and sensorimotor function.","confidence":"High","size":26,"edges":58,"triangles":5,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":24},{"id":"GO:0002024","count":24},{"id":"GO:0071502","count":24},{"id":"GO:0060134","count":21},{"id":"GO:0043278","count":21}]},{"hash":"1459760866352345419","title":"GPCR-Mediated Blood Pressure Signaling","description":"These proteins show a strong enrichment for GPCR signaling terms, especially adenylate cyclase-activating pathways and dopamine receptor signaling, which tie directly to cardiovascular regulation through renin secretion and blood pressure modulation. While a couple of terms (e.g., electron transport chain) appear less related, the dominant pattern points to GPCR-driven signaling that influences vascular tone and hormonal control. Confidence: Medium","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":24},{"id":"GO:0022900","count":24},{"id":"GO:0045777","count":24},{"id":"GO:0035025","count":23},{"id":"GO:0007191","count":22}]},{"hash":"2231445333644923677","title":"Cardiovascular GPCR Signaling","description":"The proteins cluster show strong enrichment for GPCR-mediated signaling, including adenylate cyclase-activating GPCR and dopamine receptor pathways, with links to blood pressure regulation and renin secretion; additional terms point to peptide and prostaglandin responses, suggesting a shared GPCR-regulated cardiovascular/neuroendocrine function.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":23},{"id":"GO:0022900","count":23},{"id":"GO:0045777","count":23},{"id":"GO:0007191","count":22},{"id":"GO:1900135","count":22}]},{"hash":"754686816437004382","title":"Cardiovascular GPCR Signaling and Renin Regulation","description":"This cluster centers on G protein-coupled receptor signaling that activates adenylate cyclase (including dopamine receptor pathways) and links to cardiovascular control, as evidenced by terms like positive regulation of blood pressure and positive regulation of renin secretion. Prostaglandin signaling and Rho-mediated signaling further support GPCR-driven regulatory functions, with additional notes on neural/glial context (astrocyte chemotaxis) and general peptide responses. While an electron transport chain term appears, the dominant theme is GPCR-mediated signaling connected to cardiovascular regulation and renin release.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":20},{"id":"GO:0022900","count":20},{"id":"GO:0045777","count":20},{"id":"GO:0035025","count":18},{"id":"GO:0007191","count":17}]},{"hash":"308169834418533697","title":"Cardiac Development Signaling","description":"Enriched terms point to heart development and cardiac differentiation, especially venous endothelial differentiation, Notch-regulated heart field proliferation, and right atrium morphogenesis, suggesting these proteins function together in cardiac signaling. Other terms (mRNA processing, immune signaling) are present but less dominant, so the heart development theme is the best unifying label.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071901","count":8},{"id":"GO:0060843","count":7},{"id":"GO:0007205","count":7},{"id":"GO:0003270","count":7},{"id":"GO:0003213","count":7}]},{"hash":"1110026854519970088","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0042254","count":4},{"id":"GO:0000462","count":3},{"id":"GO:0051568","count":3},{"id":"GO:0000472","count":3},{"id":"GO:0035264","count":3}]},{"hash":"60377607233667955","title":"Innate Immune Response and Inflammatory Cell Death","description":"Most terms cluster around innate immunity and inflammatory pathways (innate immune response, pyroptosis, apoptosis, inflammatory response) with ubiquitination as a key regulatory process, and NOD2 signaling contributing to immune sensing. A few terms related to mitosis or development appear but are secondary. Overall, the proteins seem to function in innate immune signaling and inflammatory cell death.","confidence":"High","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045087","count":7},{"id":"GO:0016567","count":7},{"id":"GO:0070269","count":6},{"id":"GO:0006915","count":6},{"id":"GO:1990001","count":6}]},{"hash":"1387599145886041119","title":"Angiogenesis Regulation and ECM Remodeling","description":"Top GO terms indicate a cohesive theme of vascular and extracellular matrix dynamics, with both positive and negative regulation of angiogenesis, cell-matrix adhesion, collagen fibril organization, and proteolytic processes like plasminogen activation and fibrinolysis. Receptor tyrosine kinase signaling aligns with angiogenic control, while the immune-associated term and spliceosome activity appear ancillary. Overall, this cluster centers on vascular remodeling and ECM modification.","confidence":"Medium","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045766","count":3},{"id":"GO:0007160","count":2},{"id":"GO:0007171","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0042730","count":2}]},{"hash":"476576274198677045","title":"Unknown","description":"GO terms point to diverse cellular processes (cytoskeleton remodeling, cell division, neural/immune development, cell junctions, Notch signaling, and intracellular trafficking) with no clear single function tying all proteins together.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030042","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0014005","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1}]},{"hash":"861725628161790427","title":"Unknown","description":"The top GO terms cover a mix of development (kidney, placenta, thymus), apoptosis, innate immunity, signaling (Rho), and gene silencing, with no single dominant process linking the proteins. This lack of a cohesive shared function makes a specific, intuitive cluster label inappropriate.","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097194","count":3},{"id":"GO:0019233","count":3},{"id":"GO:0001822","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0001893","count":3}]},{"hash":"1868275377284528485","title":"Unknown","description":"Unknown","confidence":"","size":26,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1904751","count":1},{"id":"GO:0032211","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0000494","count":1},{"id":"GO:0007175","count":1}]},{"hash":"1717905548736391095","title":"Regulation of diverse cell differentiation","description":"The cluster\u2019s GO terms cluster around regulation of differentiation across multiple tissues (glial, keratinocyte, myoblast, photoreceptor, endocardial) with some related stress and cellular response terms (oxidative stress, response to ATP). This suggests a shared theme of controlling cell fate decisions in diverse contexts, rather than a single, specific pathway. Translation terms appear but do not define the main theme.","confidence":"Medium","size":25,"edges":3,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":3},{"id":"GO:0071318","count":3},{"id":"GO:0045429","count":3},{"id":"GO:0006979","count":3},{"id":"GO:0060253","count":3}]},{"hash":"1814026619023943039","title":"Xenobiotic and Nutrient Transmembrane Transport","description":"The top GO terms are dominated by transmembrane transport across the plasma membrane for vitamins, xenobiotics, ions, and carbohydrates, plus related substrates like urate and selenite. This strongly suggests the cluster consists of membrane transporter proteins that shuttle diverse substrates across membranes. While a few metabolic/process terms appear, the dominant signal is transporter activity for nutrients and xenobiotics.","confidence":"High","size":25,"edges":27,"triangles":1,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":22},{"id":"GO:0006855","count":22},{"id":"GO:0042908","count":19},{"id":"GO:0071805","count":18},{"id":"GO:0008643","count":12}]},{"hash":"2216349263819455891","title":"Developmental Transcription and Growth Signaling","description":"This cluster centers on gene expression and transcription machinery (DNA-templated transcription, RNA-templated transcription, tRNA transcription by RNA Pol III, ribosome biogenesis) combined with signaling pathways related to growth and development (growth hormone receptor signaling, regulation of insulin receptor signaling) and organ development (heart morphogenesis, animal organ regeneration). The cocaine response term is peripheral and does not override the core developmental/growth theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0042220","count":2},{"id":"GO:0031100","count":2},{"id":"GO:0060396","count":2},{"id":"GO:0003007","count":2}]},{"hash":"659835336016339998","title":"Macrophage-driven inflammation and foam cell formation","description":"These GO terms cluster around innate immune activation and inflammatory response, with receptor-mediated endocytosis and lipoprotein clearance pointing to macrophage uptake of lipids and foam cell differentiation. The presence of immunological synapse formation and integrin signaling further suggests macrophage adhesion and intercellular communication, while collagen fibril organization indicates ECM remodeling associated with inflammatory environments. Together, the terms describe macrophage-driven inflammation and lipid handling, consistent with foam cell formation in atherogenic contexts.","confidence":"Medium","size":25,"edges":75,"triangles":7,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0002438","count":13},{"id":"GO:0010744","count":13},{"id":"GO:2000483","count":13},{"id":"GO:0034381","count":13},{"id":"GO:0001771","count":13}]},{"hash":"725854057131225021","title":"Multitissue Development and Cell Adhesion","description":"The top GO terms point to developmental processes across multiple tissues (skin, skeletal system, lens fibers, neurons) and to cell\u2013cell adhesion and signaling (GTPase activity, tyrosine phosphorylation) as well as mRNA transport. The diversity but cohesive theme is differentiation and organization during organism development with intercellular interactions, rather than a single pathway. Hence the label.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043588","count":5},{"id":"GO:0032516","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0070306","count":3},{"id":"GO:0001501","count":3}]},{"hash":"1493683854396600325","title":"Neuronal Sensory and Dopaminergic Signaling","description":"The cluster is enriched for sensory perception terms (pain and vision) and neural signaling, including dopaminergic synaptic transmission, membrane potential regulation, calcium release, and protein phosphorylation, indicating active neuronal communication and signaling cascades. Some GTPase regulation and prostaglandin response terms suggest broader intracellular signaling modulation within neurons. The presence of at least one non-neural term (heart development) is an outlier but does not obscure the dominant neural/sensory signaling theme. ","confidence":"Medium","size":25,"edges":266,"triangles":1672,"max_degree":24,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0007601","count":16},{"id":"GO:0007507","count":16},{"id":"GO:0071380","count":15},{"id":"GO:0043547","count":15}]},{"hash":"2273305757251831621","title":"RNA Processing and Translation Initiation","description":"This cluster is dominated by GO terms related to RNA metabolism and ribosome function, including translation initiation and preinitiation complex formation, ribosome biogenesis, and mRNA splicing/polyadenylation. While a few terms touch on broader processes like cell division and signaling, the core theme centers on RNA processing and the initiation of translation, suggesting this label accurately captures the cluster\u2019s primary function.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0002188","count":10},{"id":"GO:0001731","count":10},{"id":"GO:0006378","count":8},{"id":"GO:0045292","count":8},{"id":"GO:0042254","count":8}]},{"hash":"774225510669089056","title":"Innate antiviral immune signaling","description":"The top GO terms point strongly to antiviral defense: innate immune response, cellular response to type I interferon, cellular response to exogenous dsRNA, and negative regulation of defense response to virus by host. These indicate a coherent theme of antiviral innate immunity, despite other terms (hormone receptor assembly, prostate development) that may reflect multifunctional regulators or annotation noise. Overall, the core function appears to be antiviral signaling.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":11},{"id":"GO:0006463","count":11},{"id":"GO:0045087","count":11},{"id":"GO:0030850","count":11},{"id":"GO:0046661","count":11}]},{"hash":"1200397379458852677","title":"RNA Splicing Machinery","description":"The top GO terms point to spliceosome assembly, RNA splicing, and mRNA processing, indicating these proteins form the RNA processing/splicing machinery; a few developmental terms are likely incidental annotations rather than core functions.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0072423","count":1},{"id":"GO:0000245","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0007438","count":1}]},{"hash":"318977420136249095","title":"GTPase-regulated cytoskeleton and membrane dynamics","description":"This cluster centers on regulation of GTPase activity (both positive and negative), Ras signaling, and actin cytoskeleton organization, all of which drive membrane remodeling, cell migration, and receptor-mediated signaling. The inclusion of neuron projection morphogenesis and membrane repair further supports a theme of GTPase-driven cytoskeletal dynamics shaping cellular shape and movement, including membrane repair processes and Eph/ephrin signaling pathways.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034260","count":3},{"id":"GO:0043547","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0001778","count":2},{"id":"GO:0030036","count":2}]},{"hash":"559695918322005236","title":"Apoptosis and stress-response proteins","description":"This cluster centers on apoptotic processes (execution phase, caspase activation via cytochrome c, nurse/glial cell apoptosis) and various stress/hormone responses (glucocorticoid, estradiol, hypoxia, X-ray, xenobiotic), suggesting a cohesive module of programmed cell death tied to stress and hormonal signaling.","confidence":"High","size":25,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0008258","count":2},{"id":"GO:0051384","count":2},{"id":"GO:0034349","count":2},{"id":"GO:0008635","count":2},{"id":"GO:0010165","count":2}]},{"hash":"1008161233071406023","title":"Cardiac and neuronal GPCR signaling","description":"The top terms point to G protein-coupled receptor signaling, including acetylcholine receptor signaling, tachykinin signaling, and GPCR internalization, along with heart-related processes like heart development and cardiac muscle contraction. Additional terms such as regulation of Rho signaling, intracellular signal transduction, and neurosecretory-associated dense core granule maturation, as well as negative regulation of synaptic plasticity, suggest involvement in neuronal signaling and secretion. Together, these features indicate a cluster centered on GPCR-mediated signaling in cardiac and neural contexts.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0035023","count":3},{"id":"GO:0018107","count":2},{"id":"GO:0007213","count":2},{"id":"GO:0035556","count":2}]},{"hash":"2140453827010692904","title":"RNA Polymerase Regulation and Chromatin Dynamics","description":"Label reflects a core theme of transcription control and chromatin regulation. The most frequent GO terms center on RNA polymerase I/II/III\u2013driven transcription, including preinitiation complex assembly, transcription elongation, and transcription antitermination, plus chromatin-related processes such as histone modification and chromatin maintenance. A couple of terms refer to development (oligodendrocyte differentiation, imaginal disc wing vein specification) that are less central to this cluster, suggesting some breadth but the dominant signal remains transcription machinery and chromatin regulation.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035544","count":2},{"id":"GO:0048709","count":2},{"id":"GO:0007474","count":1},{"id":"GO:0006362","count":1},{"id":"GO:0032968","count":1}]},{"hash":"1836883865214716257","title":"Pain, Thermogenesis, and Vascular Inflammation","description":"The terms show a cohesive theme around pain perception, temperature/thermoregulation, and inflammatory/vascular processes (inflammation, lipopolysaccharide response, blood coagulation, vasoconstriction, smooth muscle regulation), suggesting a module that links nociception and temperature sensing with immune and vascular signaling.","confidence":"High","size":25,"edges":39,"triangles":3,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0002024","count":21},{"id":"GO:0071502","count":21},{"id":"GO:0042391","count":18},{"id":"GO:0006954","count":18}]},{"hash":"1897260336864865554","title":"GPCR-Mediated Cardiovascular Signaling","description":"The top terms center on adenylate cyclase-activating GPCR pathways (including dopamine receptor signaling), regulation of renin secretion and blood pressure, prostaglandin response, and Rho signaling, all pointing to GPCR-driven cardiovascular regulation. Energy-related terms like electron transport chain appear but do not define the cluster; the dominant theme is GPCR signaling tied to cardiovascular control.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":25},{"id":"GO:0022900","count":25},{"id":"GO:0045777","count":25},{"id":"GO:0035025","count":24},{"id":"GO:0007191","count":23}]},{"hash":"572162068820884488","title":"Developmental Signaling and Neural Patterning","description":"The top GO terms point to multicellular development and tissue patterning (skeletal system development, salivary gland boundary specification, general multicellular organism development) as well as signaling pathways (BMP, ERK) and neural differentiation/axonal guidance (pyramidal neuron differentiation, anterior/posterior axon guidance). This suggests a cohesive theme around developmental signaling and neural patterning, despite some annotation noise. ","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":5},{"id":"GO:0001501","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0021859","count":4},{"id":"GO:0033564","count":4}]},{"hash":"1627627489751369014","title":"Diverse catabolic metabolism and xenobiotic detox","description":"Top GO terms indicate a range of catabolic processes (lipids, chlorophyll, cellulose) alongside detox-related activities (oxidant detoxification, xenobiotic response) and related regulatory steps. The common theme is broad metabolic processing and handling of foreign compounds, rather than a single, unified pathway. Hence the label reflects metabolism-driven catabolism with detox/xenobiotic involvement.","confidence":"Medium","size":25,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0019433","count":4},{"id":"GO:0098869","count":4},{"id":"GO:0042493","count":3},{"id":"GO:0017000","count":3},{"id":"GO:2000124","count":3}]},{"hash":"1823657980391261618","title":"Immune Signaling and Apoptosis","description":"The cluster centers on immune-related pathways, including extrinsic apoptotic signaling, TNF response, and type I interferon signaling, plus lymphoid development markers like T cell homeostasis and thymus development. Decidualization hints at immune regulation in reproductive tissue, while DNA replication and protein homooligomerization appear as more general cellular processes; overall, the dominant theme is immune signaling linked to apoptosis.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0006260","count":2},{"id":"GO:0043029","count":2},{"id":"GO:0019050","count":2},{"id":"GO:0060340","count":2}]},{"hash":"1532281317810105149","title":"Rho-dependent cytoskeletal remodeling and integrin signaling","description":"The cluster shows strong representation of Rho signaling, integrin activation/regulation, and filopodium assembly, plus receptor internalization, all pointing to cytoskeletal dynamics and cell adhesion. Some terms like fibrinolysis, gluconeogenesis, and face morphogenesis are less central and may reflect broader functional connections or noise.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:0006094","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0033623","count":3}]},{"hash":"2066826395048808788","title":"Neural junction assembly and cell-surface signaling","description":"The top GO terms cluster around neural cell interfaces and signaling, including paranodal junction assembly, clustering of voltage-gated sodium channels, cell adhesion, and cell surface receptor signaling, which together point to neural development and organization of axonal/synaptic junctions (also linked to visual perception). Immune-related terms are present but appear ancillary to the main neural development theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0030913","count":5},{"id":"GO:0007275","count":4},{"id":"GO:0045162","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0007155","count":3}]},{"hash":"559502290340092724","title":"Complement and Coagulation Activation","description":"This cluster\u2019s terms are dominated by immune and hemostatic processes: several GO terms relate to complement activation (lectin and classical pathways), activation of the membrane attack complex, blood coagulation, and fibrinolysis, suggesting a theme of innate immunity linked to coagulation. Additional terms on angiogenesis and cell\u2013cell adhesion fit vascular remodeling during inflammation. Some outliers (midbrain development, fertilization) appear incidental, but the core signal points to complement-coagulation interplay.","confidence":"High","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0060244","count":4},{"id":"GO:0007596","count":4},{"id":"GO:0001970","count":4}]},{"hash":"425655251179760916","title":"Unknown","description":"The terms are highly diverse, including translation-related processes, cell cycle, neural development, germ-line formation, behavior, and viral processes, with no single unifying function across most proteins. Because there isn't a coherent theme that ties these GO terms together, a concise, representative label cannot be confidently assigned.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090116","count":1},{"id":"GO:0000289","count":1},{"id":"GO:0048136","count":1},{"id":"GO:0016032","count":1},{"id":"GO:0001662","count":1}]},{"hash":"664166232196824497","title":"Unknown","description":"The top terms are diverse (mitosis-related chromatid cohesion, nuclear import/export, actin nucleation, ribosomal export, macrophage chemotaxis) with little evidence of a single shared function across the 25 proteins, suggesting no coherent biological theme for this cluster.","confidence":"","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034087","count":1},{"id":"GO:0007064","count":1},{"id":"GO:1990022","count":1},{"id":"GO:0044376","count":1},{"id":"GO:0007165","count":1}]},{"hash":"382491623769308292","title":"Broad developmental tissue differentiation","description":"The terms point to roles in development and differentiation across multiple tissues (eye lens, nervous system, muscle, vasculature) and in cytoskeletal signaling (Rho, GTPase) rather than a single defined function, suggesting a broad, multi-tissue differentiation/signaling theme.","confidence":"Medium","size":25,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070306","count":3},{"id":"GO:0001525","count":3},{"id":"GO:1900271","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0014883","count":2}]},{"hash":"765102635879902340","title":"Protein acetylation and related biosynthetic pathways","description":"The cluster is dominated by acetylation-related GO terms (N-terminal acetylation, peptidyl-lysine acetylation, spermidine acetylation, serine acetylation) along with several biosynthetic processes (melatonin, arginine, ectoine, acetoin). This suggests a coherent theme centered on acetylation chemistry and its links to metabolism and chromatin regulation (e.g., subtelomeric heterochromatin formation). Confidence: Medium","confidence":"","size":24,"edges":10,"triangles":2,"max_degree":3,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0045150","count":13},{"id":"GO:0030435","count":11},{"id":"GO:0032918","count":10},{"id":"GO:0019491","count":10},{"id":"GO:0006348","count":10}]},{"hash":"1361855227611881249","title":"Neuroimmune Inflammation and Signaling","description":"The terms show strong inflammation and immune cell chemotaxis along with neural signaling and learning-related GO terms (dopamine receptor signaling, prepulse inhibition, visual learning), indicating a cluster of proteins involved in immune\u2013neural cross-talk and inflammatory regulation rather than a single straightforward pathway.","confidence":"Medium","size":24,"edges":40,"triangles":0,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0090026","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0002407","count":9},{"id":"GO:0006954","count":9},{"id":"GO:0060427","count":9}]},{"hash":"2291174485127297387","title":"Photoreceptor proteostasis and antiviral defense","description":"The cluster is anchored by terms tied to photoreceptor outer segment localization and response to unfolded protein (proteostasis in photoreceptors), alongside innate immune and antiviral defense terms. This suggests a theme around retina-specific protein quality control linked to immune signaling. Other terms (ubiquitination, sex differentiation, and sulfation) may reflect broader regulatory roles but do not override the retina- proteostasis-immune connection.","confidence":"Medium","size":24,"edges":187,"triangles":729,"max_degree":22,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0006986","count":7},{"id":"GO:1903546","count":7},{"id":"GO:2001162","count":7},{"id":"GO:0045087","count":7}]},{"hash":"898834936836165117","title":"Meiotic Recombination and DNA Repair","description":"The top GO terms cluster around homologous recombination, DNA repair, and meiotic processes (e.g., reciprocal meiotic recombination, double-strand break repair, telomere maintenance via recombination, oocyte karyosome formation), indicating a cohesive module of meiotic DNA processing and repair (with some related DNA integration activities). This naming captures the central theme without overreaching.","confidence":"High","size":24,"edges":151,"triangles":588,"max_degree":22,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":6},{"id":"GO:0007131","count":4},{"id":"GO:0015074","count":4},{"id":"GO:0075713","count":4},{"id":"GO:0030491","count":3}]},{"hash":"416099130985138031","title":"Neural development and dopaminergic signaling","description":"The top GO terms point mainly to neural development and neuronal signaling, with cerebral cortex development and dopaminergic synaptic transmission, plus related signaling pathways (ERK cascade) and neuronal responses (prostanoid signaling, potassium transport). The presence of DNA replication and mitotic checkpoint terms is less coherent with neurons, suggesting some housekeeping roles among the proteins, but the neural-development/neuronal signaling theme is predominant.","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0021987","count":4},{"id":"GO:0007095","count":4},{"id":"GO:0006260","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0000902","count":4}]},{"hash":"1165818833911164609","title":"Membrane ion transport","description":"The top GO terms are dominated by various ion transmembrane transport processes (potassium, sodium, nitrite, phosphate, vitamin), suggesting the cluster groups membrane transporter proteins involved in ion or substrate movement across membranes. Some vascular development terms are present but appear less central to the main theme.","confidence":"High","size":24,"edges":54,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":3},{"id":"GO:0035725","count":3},{"id":"GO:0016525","count":2},{"id":"GO:0060346","count":2},{"id":"GO:0071603","count":2}]},{"hash":"2173700524961802773","title":"Chromatin assembly and heterochromatin formation","description":"This cluster centers on chromatin organization and transcription regulation: nucleosome and chromatin assembly, replication-dependent chromatin processes, heterochromatin formation at rDNA and silent mating-type loci, and chromatin remodeling linked to transcription initiation. The GO terms collectively point to chromatin state controlling gene expression, including histone methylation regulation and nucleosome dynamics.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":5},{"id":"GO:0043388","count":3},{"id":"GO:0030466","count":2},{"id":"GO:0000183","count":2},{"id":"GO:0006335","count":2}]},{"hash":"203598317066854099","title":"Neural development and synaptic function","description":"The cluster is dominated by GO terms related to nervous system development (neuron and Schwann cell development), visual perception, and synaptic activity (long-term potentiation and excitatory postsynaptic potential), indicating a cohesive theme around neural development and synaptic signaling. A few terms like heart development and abscisic acid signaling appear peripheral or potentially as annotation noise. Therefore, the label reflects the core function of the cluster.","confidence":"High","size":24,"edges":14,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007507","count":13},{"id":"GO:0007275","count":13},{"id":"GO:0032435","count":12},{"id":"GO:0007601","count":12},{"id":"GO:0009738","count":12}]},{"hash":"1068015898275050799","title":"Cell Stress Signaling and Transcription","description":"The cluster includes GO terms tied to stress responses (response to unfolded protein, response to morphine) alongside ion transport and nuclear processes (potassium/sodium transport, nucleosome assembly, DNA-templated transcription, steroid receptor complex assembly). This mix suggests a overarching theme of cellular signaling and transcriptional regulation under stress, rather than a single specific function. Confidence: Medium","confidence":"","size":24,"edges":23,"triangles":0,"max_degree":22,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":3},{"id":"GO:0043278","count":3},{"id":"GO:0071805","count":2},{"id":"GO:0035725","count":2},{"id":"GO:0006334","count":2}]},{"hash":"1457570896888655731","title":"Hepatic fatty acid oxidation and ketogenesis","description":"This cluster is dominated by GO terms tied to liver function and fasting-related metabolism: fatty acid beta-oxidation and ketone body biosynthesis point to hepatic lipid oxidation and ketogenesis during starvation, with supporting signals for liver development and peroxisomal/glyoxysomal fatty-acid\u2013handling processes. The inclusion of amino acid catabolism terms and stress-related apoptotic regulation can reflect metabolic remodeling under energy stress but do not override the central hepatic lipid metabolism theme.","confidence":"High","size":24,"edges":276,"triangles":2024,"max_degree":23,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042594","count":10},{"id":"GO:0001889","count":10},{"id":"GO:0006635","count":9},{"id":"GO:0046951","count":9},{"id":"GO:0006550","count":8}]},{"hash":"1237576922042986539","title":"Developmental gene expression and translation initiation","description":"The Top Terms show a strong emphasis on developmental processes (multicellular organism development, forebrain, skeletal system, and prostate gland development) alongside gene expression machinery (DNA-templated transcription and translation initiation terms). This suggests a cluster of proteins involved in developmental programs and the core machinery for initiating transcription/translation, rather than a single focused pathway. Confidence: Medium","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":6},{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0001501","count":5},{"id":"GO:0006351","count":5}]},{"hash":"714009496247513205","title":"Cell Cycle and Protein Complex Assembly","description":"This cluster centers on proteins involved in mitotic progression and the formation of protein complexes (cell division, metaphase/anaphase transition, protein heterooligomerization, steroid hormone receptor complex assembly). It also includes signs of protein quality control in the ER (response to unfolded protein, ER-associated processes) and several signaling pathways (cytokinin, gibberellin) that tie into plant hormone signaling. A few terms about stress responses (morphine, lead ion) appear as noise, but the dominant theme remains cell cycle control and assembly of protein complexes with associated signaling. ","confidence":"Medium","size":24,"edges":38,"triangles":1,"max_degree":11,"top_function":"photosynthesis","top_go_terms":[{"id":"GO:0051301","count":9},{"id":"GO:0051291","count":9},{"id":"GO:0043278","count":9},{"id":"GO:0006986","count":8},{"id":"GO:0009938","count":8}]},{"hash":"2022209881324418112","title":"Androgen signaling in male reproductive development","description":"The cluster is enriched for male reproductive development and steroid signaling terms (male sex differentiation, steroid hormone receptor complex assembly, prostate gland development), suggesting a cohesive module of androgen signaling; immune/stress terms appear but are secondary noise.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046661","count":8},{"id":"GO:0006463","count":8},{"id":"GO:0030850","count":8},{"id":"GO:0071357","count":8},{"id":"GO:0006986","count":7}]},{"hash":"2108131556889366885","title":"RNA processing and miRNA/RISC machinery","description":"This cluster is dominated by GO terms related to RNA processing (rRNA, mRNA, pre-miRNA) and RNA interference components (RISC complex assembly, miRNA metabolic regulation). These terms suggest a shared function in RNA maturation and RNA silencing pathways, with additional, less central links to cell cycle and apoptosis signaling. The combination points to a core theme of RNA processing and miRNA/RISC machinery among the proteins.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006364","count":3},{"id":"GO:0071157","count":2},{"id":"GO:0097049","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0043547","count":2}]},{"hash":"1915857197119857097","title":"Mitochondrial respiration and redox balance","description":"GO terms cluster around mitochondrial electron transport (NADH to ubiquinone), TCA-related metabolism (2-oxoglutarate), and redox regulation (membrane potential, redox homeostasis), including dihydrolipoamide metabolism; together these indicate a module focused on mitochondrial energy production and redox control, with a few peripheral terms (aging, sperm capacitation) not altering the core theme.","confidence":"High","size":24,"edges":10,"triangles":0,"max_degree":5,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0008283","count":13},{"id":"GO:0006120","count":13},{"id":"GO:0007568","count":13},{"id":"GO:0051068","count":13},{"id":"GO:0045454","count":13}]},{"hash":"1875895116415669445","title":"MAPK signaling in apoptosis and nervous system development","description":"The dominant terms point to MAPK pathways (ERK1/2 and JNK cascades) regulating apoptosis, plus neural and nervous system development, with some tissue-specific apoptosis signals (e.g., cardiac muscle). A few peripheral terms exist (immune-related response, protein localization to cell surface) but do not override the central MAPK-apoptosis-neural theme.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0097194","count":3},{"id":"GO:0071225","count":3},{"id":"GO:0043525","count":3},{"id":"GO:0032094","count":3}]},{"hash":"2015272916552655109","title":"Hair Follicle Morphogenesis and Keratinocyte Development","description":"GO terms emphasize epidermal development and hair biology (keratinocyte development, epithelial morphogenesis, hair follicle morphogenesis) plus wound healing and signaling (Wnt and ERK cascades). Together these terms point to a functional module governing skin morphogenesis and hair follicle formation.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031532","count":4},{"id":"GO:0044319","count":3},{"id":"GO:0003382","count":3},{"id":"GO:0003334","count":3},{"id":"GO:0031069","count":3}]},{"hash":"758482094308376730","title":"Ubiquitin-Proteasome Pathway & Stress Response","description":"This cluster is dominated by terms for ubiquitin-dependent proteolysis (including SCF-dependent pathways) and protein polyubiquitination, suggesting a core role in ubiquitin-proteasome\u2013mediated degradation. Additional terms on circadian rhythm regulation and responses to heavy metals/oxidative stress imply coordinated turnover of clock-related and stress-damaged proteins, linking degradation to stress signaling and cell-cycle control.","confidence":"High","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0042787","count":19},{"id":"GO:0031146","count":14},{"id":"GO:0042752","count":14},{"id":"GO:0000083","count":13},{"id":"GO:1903378","count":13}]},{"hash":"2256178686219516043","title":"MAPK Pathway Regulators in Development and Immunity","description":"The top GO terms point to regulation of JNK and ERK cascades (MAPK signaling) and mechanotransduction, plus nervous system and heart development and immune-related processes. This suggests proteins that broadly modulate MAPK signaling across developmental, mechanosensory, and immune contexts, rather than a single, narrow pathway. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0046330","count":8},{"id":"GO:0051092","count":8},{"id":"GO:0071260","count":8},{"id":"GO:0043552","count":8},{"id":"GO:0070374","count":8}]},{"hash":"1255968137097318268","title":"Unknown","description":"The GO terms are heterogeneous: glycogen metabolism, proteasome assembly, transcription initiation, spindle checkpoint signaling, and various immune/adhesion processes. There is no single dominant theme linking these proteins, so a concise, specific label isn\u2019t apparent.","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000467","count":1},{"id":"GO:0005981","count":1},{"id":"GO:0045725","count":1},{"id":"GO:0005977","count":1},{"id":"GO:0043248","count":1}]},{"hash":"1762599679198157315","title":"Synaptic vesicle cycling proteins","description":"The top GO terms center on presynaptic dense core vesicle exocytosis, synaptic vesicle maturation, and vesicle priming, pointing to a cohesive role in the presynaptic vesicle cycle and neurotransmitter release. Minor terms about signaling pathways do not override this core theme. Overall, the cluster is best described as proteins involved in the synaptic vesicle cycle.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0099525","count":3},{"id":"GO:0016188","count":3},{"id":"GO:0050853","count":2},{"id":"GO:0046626","count":2},{"id":"GO:0030036","count":2}]},{"hash":"609261507264261578","title":"Dopaminergic Signaling and Thermogenesis","description":"This cluster is dominated by terms tying neural signaling and thermogenesis: sensory pain, temperature stimulus, and diet-induced thermogenesis, plus dopamine receptor signaling and ERK cascades downstream of GPCRs, with membrane potential and GTPase activity supporting neuronal excitability. The presence of astrocyte chemotaxis and peptide response suggests a CNS context. Overall, it reflects dopaminergic signaling linked to temperature- and pain-related responses in neural/metabolic regulation.","confidence":"Medium","size":24,"edges":76,"triangles":33,"max_degree":13,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":22},{"id":"GO:0002024","count":22},{"id":"GO:0071502","count":22},{"id":"GO:0043547","count":20},{"id":"GO:0042391","count":20}]},{"hash":"2122217257339000628","title":"Regulated signaling and synaptic activity","description":"This cluster centers on regulation of signaling cascades (GTPase regulation, kinase activity, NF-kappaB signaling) and processes linked to neuronal communication (regulation of synaptic vesicle endocytosis, excitatory postsynaptic potential). The presence of proliferation and hypoxia-related terms suggests broader regulatory roles, but the strongest cohesive theme is controlled signaling and synaptic function.","confidence":"Medium","size":24,"edges":5,"triangles":0,"max_degree":5,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":7},{"id":"GO:0071456","count":6},{"id":"GO:0000278","count":6},{"id":"GO:0008284","count":6},{"id":"GO:1900242","count":6}]},{"hash":"1819504479564565805","title":"PNS axon guidance and neural crest migration","description":"The cluster is enriched for axon guidance terms (axonal fasciculation, sympathetic neuron projection guidance, trigeminal nerve organization) and neural crest migration, including semaphorin-plexin signaling in axon guidance. Together these terms indicate proteins involved in peripheral nervous system development and neuronal pathfinding, with supporting signaling in Rho and STAT pathways that regulate cytoskeletal dynamics during navigation.","confidence":"High","size":24,"edges":16,"triangles":0,"max_degree":5,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007413","count":8},{"id":"GO:0036486","count":7},{"id":"GO:0097491","count":7},{"id":"GO:0021785","count":7},{"id":"GO:0097490","count":7}]},{"hash":"1797016109233118782","title":"Neuronal synapse organization and signaling","description":"This cluster is driven by GO terms centered on synapse organization, receptor clustering, and dendritic spine morphogenesis, complemented by signaling-related processes (activation of GTPase activity; regulation of opioid receptor signaling; regulation of serotonin uptake). The presence of sensory perception of sound and grooming behavior terms suggests neuronal/sensory-context functions, supporting a theme of neuronal synapse development and signaling, even though a few outliers (e.g., endothelial barrier establishment) are present. ","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090630","count":5},{"id":"GO:0007605","count":5},{"id":"GO:0051612","count":4},{"id":"GO:0043113","count":4},{"id":"GO:2000474","count":4}]},{"hash":"611463099477068663","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"This cluster is dominated by ubiquitin-related processes (ubiquitin-dependent protein catabolic process, K63-linked ubiquitination, autoubiquitination) alongside innate immune responses (innate immune response, TNF signaling, NF-kB regulation) and antiviral defenses (control of viral material transport and viral RNA replication). The strongest common theme is ubiquitin-driven regulation of innate immune signaling and antiviral responses, with some auxiliary terms relating to microtubule localization and other less central processes. ","confidence":"Medium","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0070534","count":9},{"id":"GO:0045087","count":9},{"id":"GO:1903265","count":9},{"id":"GO:1901253","count":9}]},{"hash":"410713290988052590","title":"Membrane raft organization and trafficking","description":"The terms point to membrane microdomain organization and trafficking processes: eisosome assembly, membrane raft polarization, transcytosis, and signaling regulation at membranes, plus endothelial barrier establishment and cell adhesion modulation. Neural development and myelination terms likely reflect membrane-related roles in neurons and glia. Together, these suggest a coherent theme around membrane domain organization and intracellular trafficking across cell types, rather than a single linear pathway.","confidence":"Medium","size":24,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0070941","count":2},{"id":"GO:0048172","count":2},{"id":"GO:0042552","count":2},{"id":"GO:0021762","count":2},{"id":"GO:0034115","count":2}]},{"hash":"1700451765179804246","title":"Ubiquitin-Dependent Immune Signaling","description":"The terms are dominated by ubiquitin-mediated protein catabolism (ubiquitination, autoubiquitination, K6-linked), indicating regulators of protein turnover. Immune-related terms\u2014innate immune response, activation of NF-kappaB-inducing kinase, regulation of JNK cascade, and positive regulation of TNF signaling\u2014point to ubiquitin-dependent control of immune signaling. A note on circadian rhythm and histone catabolic processes suggests broader transcriptional and timing regulation that can intersect immunity. Overall, this cluster likely comprises ubiquitin-regulating proteins that modulate innate immune pathways.","confidence":"High","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":20},{"id":"GO:1903265","count":10},{"id":"GO:0036205","count":10},{"id":"GO:0051865","count":10},{"id":"GO:0085020","count":10}]},{"hash":"2276711360218255910","title":"Unknown","description":"The GO terms are very diverse (DNA repair, pain perception, Wnt signaling, potassium response, nonsense-mediated decay, T cell differentiation, apoptosis, cognition) with no clear shared pathway or function, and there are no edges connecting proteins, making a cohesive label undefined. Also the presence of obsolete GO terms suggests inconsistent annotation. Therefore, Unknown with None confidence. ","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0016055","count":2},{"id":"GO:0035865","count":1},{"id":"GO:0061400","count":1}]},{"hash":"465446351193512838","title":"Unknown","description":"Unknown","confidence":"","size":24,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071031","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0071039","count":1},{"id":"GO:0071030","count":1},{"id":"GO:0000460","count":1}]},{"hash":"1184134760618335777","title":"GPCR-mediated cardiovascular signaling and actin remodeling","description":"The top GO terms point to GPCR signaling and cardiovascular-related processes (heart development, vasoconstriction, prostaglandin response, insulin signaling) along with actin cytoskeleton organization and GPCR internalization, suggesting a cohesive theme of GPCR-driven signaling regulating heart/vascular function and cytoskeletal dynamics. Some terms like sensory perception of sound may be peripheral noise, but the dominant signal centers on GPCR-mediated cardiovascular signaling.","confidence":"Medium","size":23,"edges":2,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":3},{"id":"GO:0007205","count":3},{"id":"GO:0030036","count":3},{"id":"GO:0071380","count":3},{"id":"GO:0045907","count":3}]},{"hash":"1171891594197570357","title":"Developmental and vascular signaling","description":"The terms cluster around multicellular development, proliferation, and responses to hypoxia, with supporting signals for blood coagulation, cell-matrix adhesion, and GTPase-regulated signaling, suggesting a coordinated developmental and vascular remodeling program.","confidence":"Medium","size":23,"edges":4,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0007596","count":5},{"id":"GO:0070208","count":5},{"id":"GO:0071456","count":5},{"id":"GO:0008284","count":5}]},{"hash":"2048364264449759541","title":"Mitotic proliferation and ER\u2013Golgi vesicle transport","description":"The cluster\u2019s top GO terms center on cell division and the mitotic cell cycle, plus mitotic spindle assembly, and prominently on vesicle trafficking between the ER and Golgi (COPII budding; ER\u2013Golgi and Golgi\u2013ER transport). Developmental terms like brain development and multicellular organism growth provide context for how these processes may operate during development. Together, they point to proteins involved in both cell proliferation and secretory pathway dynamics during development.","confidence":"High","size":23,"edges":44,"triangles":14,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0007420","count":7},{"id":"GO:0006890","count":7},{"id":"GO:0008283","count":7},{"id":"GO:0090114","count":7}]},{"hash":"588941716546571403","title":"APC/C-mediated mitosis and chromatin regulation","description":"The prominent GO terms center on cell division and mitotic control (mitotic cell cycle; anaphase-promoting complex-dependent catabolic process) and ubiquitin signaling (K11-linked ubiquitination) typical of APC/C-driven proteolysis during mitosis, and histone H3-K79 methylation regulation suggesting chromatin modulation. While there are some stress- and tissue-specific terms (cadmium response, dsRNA response, unfolded protein, photoreceptor localization, plant hormone signaling) these appear as residual or context-specific associations; the dominant theme across the top terms is mitotic progression coupled with ubiquitin-mediated protein degradation and chromatin regulation.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:2001162","count":4},{"id":"GO:0070979","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0000278","count":4}]},{"hash":"1845595480107641278","title":"Leukocyte activation and adhesion","description":"This cluster\u2019s top GO terms center on immune-related processes: positive regulation of alpha-beta T cell differentiation, regulation of leukocyte chemotaxis, and positive regulation of cell-matrix adhesion, pointing to immune cell activation, trafficking, and adhesion to the extracellular matrix. Additional terms like response to antibiotic/cocaine and methylation/DNA integration suggest stress and epigenetic context, but the dominant theme appears to be leukocyte signaling and interactions with the surrounding environment. Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0019284","count":2},{"id":"GO:0046638","count":2},{"id":"GO:0019509","count":2}]},{"hash":"82312452405540900","title":"Ribosome Biogenesis and RNA Processing","description":"This cluster is dominated by GO terms for ribosome assembly and rRNA maturation (maturation of SSU and LSU rRNA, ribosomal large subunit biogenesis, and preinitiation/translation initiation steps). The inclusion of spliceosome-mediated mRNA splicing and regulatory ncRNA-related silencing suggests broader RNA processing networks linked to ribosome production. Taken together, the proteins likely function together in ribosome biogenesis and the early stages of translation. ","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0042273","count":10},{"id":"GO:0048026","count":10},{"id":"GO:0000462","count":9},{"id":"GO:0000209","count":9},{"id":"GO:0000466","count":9}]},{"hash":"11860172967114594","title":"RNA processing and translation initiation","description":"The cluster centers on RNA metabolism and control of translation, with terms for translation initiation, preinitiation complex formation, mRNA export and stabilization, and stress-related mRNA stability, plus ribosome-associated processing and ncRNA-mediated silencing. This suggests proteins involved in processing, exporting, stabilizing, and translating mRNAs, under regulatory control by ncRNAs and stress responses.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0002188","count":10},{"id":"GO:0001731","count":10},{"id":"GO:0010610","count":10},{"id":"GO:0006378","count":10},{"id":"GO:1902625","count":9}]},{"hash":"225969497683934809","title":"Mitotic cell cycle control and transcription","description":"The cluster is strongly enriched for DNA-templated transcription and pivotal mitotic transitions (G1/S and G2/M), along with chromosome condensation and CDK activity regulation. Additional terms for mammary gland epithelial proliferation and placenta development suggest broader developmental proliferation contexts, but the dominant signal is coordinated transcriptional control with mitotic progression, indicating a cohesive module of cell-cycle\u2013regulating proteins.","confidence":"High","size":23,"edges":161,"triangles":653,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":18},{"id":"GO:0000082","count":18},{"id":"GO:0000086","count":18},{"id":"GO:2000775","count":17},{"id":"GO:0033598","count":17}]},{"hash":"868196429095730699","title":"RNA Processing and Translation","description":"The cluster\u2019s GO terms cluster around RNA metabolism and protein synthesis: maturation of rRNA, mRNA capping, RNA methylation, tRNA ribose methylation, and cytoplasmic translation, suggesting a core function in RNA processing and translation. A couple of terms (cerebellar granule cell differentiation, viral processes) appear less central to this theme but do not override the main RNA/translation focus.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0035556","count":2},{"id":"GO:0021707","count":2},{"id":"GO:0039654","count":1},{"id":"GO:0000463","count":1},{"id":"GO:0002181","count":1}]},{"hash":"226762108451615082","title":"Unknown","description":"The GO terms are highly disparate, with a couple tied to heart development (SA node action potential regulation and outflow tract morphogenesis) but many others referencing skin development, membrane repair, caffeine response, immune signaling, and obsolete processes, and there are no observed interactions among the proteins. This points to a heterogeneous set rather than a coherent functional module.","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098907","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0030433","count":1},{"id":"GO:0043569","count":1},{"id":"GO:0001778","count":1}]},{"hash":"1846348484548684264","title":"Developmental morphogenesis and axon guidance","description":"The terms cluster around tissue morphogenesis (palatal shelf, lung branching, planar polarity) and neuronal pathfinding (dopaminergic and serotonergic axon guidance), with supporting roles for cell adhesion and Notch pathway regulation, indicating a theme of developmental patterning and guidance cues.","confidence":"High","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:1990134","count":7},{"id":"GO:0045746","count":7},{"id":"GO:0036514","count":7},{"id":"GO:0060489","count":7},{"id":"GO:0007156","count":7}]},{"hash":"1649051567775879311","title":"Neural and Eye Development","description":"This cluster centers on neural and sensory organ development, with frequent terms for forebrain, cerebellum, retina, and visual perception, plus neuronal differentiation and motor axon guidance. While there are also broad terms for heart and skeletal muscle development, the strongest, cohesive signal is nervous system and eye development.","confidence":"Medium","size":23,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":6},{"id":"GO:0007507","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0008584","count":5},{"id":"GO:0021549","count":5}]},{"hash":"1264326365008957399","title":"Neurodevelopment and Innate Immunity","description":"The cluster is dominated by neural development terms: axonogenesis, axonal fasciculation, sympathetic neuron projection guidance, and neural crest migration, indicating a cohesive neurodevelopmental program. Additional terms point to broader developmental processes (muscle contraction, bone ossification) and an innate immune response, suggesting a developmental context that also engages innate immunity signals. Overall, the most representative theme is neurodevelopment with supportive immune-related signals.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0006936","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0043931","count":2}]},{"hash":"1267747791002940214","title":"Immune Activation and Necroptosis Signaling","description":"The cluster centers on immune and inflammatory processes, with terms for thymus development, T cell proliferation, NF-kappaB signaling, and platelet activation, plus necroptotic signaling and death-inducing signaling complex assembly. These together suggest a cohesive theme of immune activation coupled to regulated cell death pathways; some terms like responses to cocaine/morphine and mechanical stimulus may reflect broader stress-related signaling that can intersect immune responses.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048538","count":2},{"id":"GO:0097527","count":2},{"id":"GO:0042104","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0046325","count":2}]},{"hash":"22459981335543674","title":"Embryonic skeletal morphogenesis signaling","description":"The terms cluster around skeletal system development, embryonic cranial skeleton morphogenesis, and key signaling pathways (BMP, Hedgehog/SMO, ERK), indicating a shared role in signaling-driven skeletal morphogenesis during development. Some terms (myelination, synapse assembly) are broader but do not override the core theme.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030513","count":3},{"id":"GO:0051092","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0042552","count":3}]},{"hash":"103215457402475119","title":"Signaling and Growth Regulation","description":"This cluster centers on diverse regulatory signals and growth/differentiation processes, evidenced by GO terms for Wnt signaling, NOD2 signaling, receptor-mediated regulation of synaptic activity, transcription and mRNA processing control, endothelial differentiation, epithelial polarity, and telomere maintenance\u2014pointing to a broad regulatory network rather than a single pathway. Confidence: Medium","confidence":"","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":6},{"id":"GO:0070431","count":6},{"id":"GO:0000083","count":6},{"id":"GO:0006397","count":6},{"id":"GO:0045083","count":6}]},{"hash":"770871339752222433","title":"Organ Morphogenesis and Patterning","description":"These proteins cluster around developmental processes across multiple organs, including cardiac ventricle and outflow tract morphogenesis, glomerular mesangial cell development, ciliary body morphogenesis, and prostate gland differentiation, along with heterophilic cell-cell adhesion and regulation of stem cell differentiation. The common thread is embryonic organogenesis and tissue patterning rather than a single tissue-specific function, justifying a label focused on organ morphogenesis and patterning.","confidence":"High","size":23,"edges":18,"triangles":0,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071372","count":21},{"id":"GO:2000737","count":20},{"id":"GO:1900127","count":20},{"id":"GO:0072144","count":20},{"id":"GO:0007157","count":20}]},{"hash":"495526808804627524","title":"Potassium Channels and Membrane Potential Regulation","description":"The top GO terms cluster around potassium ion transport and homeostasis, membrane potential stabilization/regulation, and cardiac action potential repolarization, suggesting a module centered on potassium channel function that governs cellular excitability and voltage dynamics, with ancillary links to sensory signaling and metabolic responses.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0019233","count":12},{"id":"GO:0007275","count":10},{"id":"GO:0002024","count":8},{"id":"GO:0071502","count":8},{"id":"GO:0071805","count":8}]},{"hash":"1193008848384628259","title":"Dopaminergic GPCR signaling and synaptic regulation","description":"Most terms point to dopamine receptor signaling and related GPCR pathways (GO:0007191) with connections to dopamine uptake, prostaglandin responses, and astrocyte chemotaxis, suggesting a neuronal/glial network centered on dopamine-mediated signaling and synaptic regulation. The recurring theme across terms is dopaminergic GPCR signaling and modulation of synaptic activity.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":23},{"id":"GO:1900135","count":23},{"id":"GO:2000458","count":23},{"id":"GO:1901652","count":23},{"id":"GO:0018298","count":23}]},{"hash":"2129563243397106037","title":"Vascular inflammation and coagulation signaling","description":"This cluster centers on inflammatory responses and vascular reactivity, including positive regulation of vasoconstriction, LPS response, prostaglandin signaling, GPCR internalization, GTPase activity, and blood coagulation, with an additional note of heart-related signaling. These terms together suggest a cohesive module of inflammation-driven vascular activity and coagulation processes rather than unrelated functions.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":11},{"id":"GO:0006954","count":10},{"id":"GO:0019233","count":10},{"id":"GO:0032496","count":10},{"id":"GO:0007596","count":10}]},{"hash":"1398109726237493725","title":"Cardiac and neural development","description":"The dominant terms point to development-related processes in the heart and nervous system (heart development, cardiac muscle contraction, angiogenesis regulation, axonogenesis) with associated signaling (Rho) and transcriptional regulation, suggesting a cardiovascular-plus-neural development theme. Some outliers (bioluminescence, photoprotection) appear incidental.","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008218","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0007409","count":2}]},{"hash":"920432436543554737","title":"Growth factor signaling and axon guidance","description":"The top terms cluster around receptor tyrosine kinase signaling, Hedgehog (Smoothened) pathway regulation, hepatocyte growth factor receptor signaling, and axon extension/guidance, along with broader developmental processes like coronary morphogenesis. This suggests the proteins participate in coordinated developmental signaling networks that influence neural wiring and tissue development, with a few outliers (e.g., immune-related term) that are less central. ","confidence":"Medium","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":8},{"id":"GO:0007171","count":6},{"id":"GO:0045880","count":5},{"id":"GO:0048842","count":5},{"id":"GO:0018996","count":5}]},{"hash":"221936926201030606","title":"Transmembrane Transporters for Ions and Metabolites","description":"This cluster is dominated by GO terms for transmembrane transport of diverse substrates, including potassium, sodium, nitrite, nitrate, phosphate, vitamins, galactose, fucose, and 4-hydroxyphenylacetate, indicating a cohesive transporter function. A single cell surface receptor signaling term appears but is not central to the main theme. ","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007166","count":2},{"id":"GO:0071805","count":2},{"id":"GO:0015707","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0035725","count":2}]},{"hash":"876801825150832966","title":"Blood coagulation and matrix remodeling","description":"The top GO terms are dominated by coagulation and fibrinolysis regulators (Factor XII activation; positive regulation of fibrinolysis and plasminogen activation; positive regulation of blood coagulation). Collagen catabolic process and bone trabecula formation point to extracellular matrix remodeling. Together, these suggest a cluster of proteins involved in hemostasis and remodeling of connective tissue.","confidence":"High","size":23,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002542","count":3},{"id":"GO:0051919","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0010756","count":3},{"id":"GO:0016525","count":3}]},{"hash":"1211084868162342180","title":"Developmental and immune signaling","description":"The proteins are enriched for multiple signaling pathways (Smoothened and Roundabout), alongside developmental terms (kidney, nervous system, spermatid development) and immune signaling (T cell receptor). Additional terms on ERK cascade regulation and calcium-dependent exocytosis point to broad signal transduction roles affecting development and immune responses, with a minor cue from copper homeostasis. This suggests a cluster of proteins involved in diverse signaling functions pertinent to development and immunity rather than a single pathway.","confidence":"Medium","size":22,"edges":92,"triangles":163,"max_degree":16,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007224","count":19},{"id":"GO:0001822","count":19},{"id":"GO:0007399","count":19},{"id":"GO:0035385","count":18},{"id":"GO:0050852","count":18}]},{"hash":"1429545981571519915","title":"Mitotic Regulation and Cellular Stress Responses","description":"The cluster is dominated by a strong signal for cell-cycle control (positive regulation of G1/S transition) alongside multiple stress- and regulation-related terms (response to xenobiotic stimulus, redox homeostasis, DNA recombination, and regulation of mRNA stability). While some terms are obsolete, the recurring themes point to a cohesive theme of coordinating cell-cycle progression with cellular stress and gene-expression regulation, rather than a single narrow pathway like metabolism or immune signaling.","confidence":"Medium","size":22,"edges":111,"triangles":187,"max_degree":16,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:1900087","count":10},{"id":"GO:0042493","count":9},{"id":"GO:2000466","count":8},{"id":"GO:0080111","count":8},{"id":"GO:0007568","count":8}]},{"hash":"66682689145092755","title":"Neuronal vesicle trafficking and exocytosis","description":"The cluster's GO terms cluster around synaptic vesicle priming, presynaptic dense core vesicle exocytosis, and endocytosis, indicating a cohesive theme of vesicle trafficking and neurotransmitter release; mitochondrial respiration terms suggest the energy supply supporting these processes, with a few terms touching on broader secretory pathways like insulin secretion and egg activation as related contexts. Overall, the label captures a vesicle trafficking/exocytosis theme with metabolic context.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034553","count":1},{"id":"GO:0006120","count":1},{"id":"GO:0007343","count":1},{"id":"GO:0016082","count":1},{"id":"GO:0035773","count":1}]},{"hash":"1347201651372385807","title":"Immune Cell Signaling and T Cell Differentiation","description":"This cluster is dominated by GO terms tied to immune cell development and signaling, including positive regulation of gamma-delta and alpha-beta T cell differentiation, regulation of leukocyte chemotaxis, and signaling cascades like tyrosine/serine phosphorylation of STAT proteins and erythropoietin-mediated signaling. A few terms related to reproductive development appear incidental and do not clearly define the core function. Overall, the set points to immune cell differentiation and signaling as the central theme.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0040022","count":1},{"id":"GO:0000387","count":1},{"id":"GO:0045588","count":1},{"id":"GO:0001954","count":1},{"id":"GO:0002688","count":1}]},{"hash":"1925557580744771914","title":"Glycan biosynthesis and sperm-egg interaction","description":"This cluster combines several glycan- and proteoglycan biosynthetic processes (keratan sulfate proteoglycan, glycosphingolipid, lactose) with key sperm\u2013egg interaction steps (binding to and penetration of the zona pellucida, acrosome reaction regulation), pointing to a theme of cell-surface glycoconjugate biology governing fertilization. Some developmental terms appear as secondary associations, but the reproductive glycan-centric signals predominate.","confidence":"Medium","size":22,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0018146","count":4},{"id":"GO:0021680","count":4},{"id":"GO:0060046","count":4},{"id":"GO:0006688","count":4},{"id":"GO:0007341","count":4}]},{"hash":"184983319026171846","title":"Neural development and neural crest morphogenesis","description":"The top GO terms cluster around neural development and neural crest\u2013related processes (floor plate, spinal cord neuron fate, vestibular and amacrine neuron development, branchiomeric muscle formation, and cardiac neural crest\u2013driven morphogenesis), with somitogenesis and synapse maturation suggesting broader developmental coordination. This alignment supports a theme of neural development with neural crest\u2013mediated organogenesis.","confidence":"High","size":22,"edges":194,"triangles":1098,"max_degree":20,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":13},{"id":"GO:0001756","count":10},{"id":"GO:0033504","count":10},{"id":"GO:0021520","count":10},{"id":"GO:0060426","count":10}]},{"hash":"522632047198596652","title":"Developmental Migration and Growth-Factor Signaling","description":"The cluster centers on developmental cell migration and growth-factor signaling, highlighted by neural crest and GnRH neuronal migration terms and signaling pathways such as HGF and VEGF receptors, along with adhesion/junction assembly terms that support cell movement. Innate immune terms appear but are secondary to the migration and signaling themes, suggesting a developmental, vascular, and signaling-focused cluster. ","confidence":"Medium","size":22,"edges":93,"triangles":143,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0045087","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0048012","count":4},{"id":"GO:0036486","count":4}]},{"hash":"1730119890029278892","title":"Amino acid metabolism and central carbon metabolism","description":"The top GO terms are dominated by metabolic processes, including the TCA cycle, pyruvate and various amino acid catabolic/biosynthetic pathways, plus biosynthesis of cofactors and antibiotics. Notch signaling and transcription appear less strongly, suggesting the proteins are primarily involved in metabolism with some regulatory annotations. This supports labeling the cluster as centered on amino acid and central carbon metabolism.","confidence":"Medium","size":22,"edges":228,"triangles":1480,"max_degree":21,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006099","count":6},{"id":"GO:0042853","count":6},{"id":"GO:0019878","count":6},{"id":"GO:0007219","count":5},{"id":"GO:0097053","count":5}]},{"hash":"1009771827825291235","title":"Lipid, carbohydrate, and amino acid metabolism","description":"These proteins cluster around multiple metabolic biosynthetic and catabolic processes: lipid pathways (carnitine biosynthesis, long-chain fatty acid catabolic, steroid biosynthesis), carbohydrate metabolism (glycogen biosynthesis), and amino acid degradation (leucine catabolic). While there are a few outliers related to development, the dominant theme is energy/metabolic processing across these macromolecules, making a metabolism-focused label appropriate. ","confidence":"Medium","size":22,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0045329","count":3},{"id":"GO:0006552","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0005978","count":2}]},{"hash":"1569810150976719285","title":"Unknown","description":"Unknown","confidence":"","size":22,"edges":231,"triangles":1540,"max_degree":21,"top_function":null,"top_go_terms":[{"id":"GO:0000961","count":2},{"id":"GO:0090502","count":2},{"id":"GO:0042793","count":2},{"id":"GO:0001682","count":2},{"id":"GO:0070129","count":2}]},{"hash":"54426705292488912","title":"Neuronal chloride homeostasis and synaptic signaling","description":"This cluster centers on ion transport and neuronal signaling. The top GO terms include intracellular chloride ion homeostasis, chemical synaptic transmission, dendritic spine development, and transepithelial/ transmembrane transport, suggesting proteins involved in chloride regulation linked to synaptic function and related cell-volume responses. The terms collectively point to a coherent theme of neuronal ion transport affecting synaptic activity.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060996","count":1},{"id":"GO:0030321","count":1},{"id":"GO:0035826","count":1},{"id":"GO:0007268","count":1},{"id":"GO:0030644","count":1}]},{"hash":"1870137206681332772","title":"Ribosome biogenesis and ER quality control","description":"The terms include maturation of SSU rRNA, small subunit assembly, and translation, which point to ribosome biogenesis; alongside ERAD, ER overload response, ER-to-cytosol transport, and ER stress\u2013related signaling, indicating ER quality control/ stress response. This suggests a cluster encompassing both protein synthesis machinery and ER homeostasis mechanisms, possibly linked by coordination between translation and ER stress management.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":1},{"id":"GO:0000028","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0030433","count":1},{"id":"GO:0002865","count":1}]},{"hash":"1348624146177906137","title":"Immune signaling and cytokine regulation","description":"The cluster\u2019s top GO terms center on innate and adaptive immune signaling: TLR9 signaling, Th1-type immune responses, and regulation of cytokines such as IL-6, IL-17, and IL-23, plus defense against Gram-negative bacteria and activation of the JNK/MAPK cascade and chemokine production. This points to a cohesive theme of immune activation and inflammatory cytokine control. Some terms like cellular response to mechanical stimulus or chloroquine are broader context signals but do not override the core immune-focused pattern. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":3},{"id":"GO:0042088","count":3},{"id":"GO:0032707","count":3},{"id":"GO:0071260","count":3},{"id":"GO:0032700","count":2}]},{"hash":"276474899107083128","title":"Embryonic mesenchymal development and signaling","description":"The terms cluster around embryonic tissue morphogenesis across multiple organs (cartilage condensation, intramembranous ossification, skin, kidney, nervous system, lung mesenchyme development) and include signaling pathways (FGF/MAPKKK, Rho) that regulate morphogenesis. This points to a cohesive theme of mesenchyme-driven development and its signaling controls.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001502","count":5},{"id":"GO:0043588","count":4},{"id":"GO:0035023","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0007399","count":4}]},{"hash":"1213135029446412572","title":"Thymic T Cell Development and Signaling","description":"The cluster centers on thymus development and T cell maturation, with terms like thymus development, beta selection, and T cell receptor signaling, plus signaling pathway regulation (ERK cascade). While there are immune defense terms (innate response, defense against Gram-positive bacteria) and angiogenesis-related terms, the dominant theme appears to be T cell development and activation signaling within a immune context. This suggests a module of developing T cells engaging receptor signaling and downstream ERK pathways, with some accompanying tissue remodeling signals. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":4},{"id":"GO:0071226","count":3},{"id":"GO:0048538","count":3},{"id":"GO:0043552","count":3},{"id":"GO:0050830","count":3}]},{"hash":"507268457550468482","title":"ER protein folding and stress response","description":"Dominated by endoplasmic reticulum\u2013related terms: protein folding in the ER and response to ER stress, plus redox homeostasis and oxidant detoxification. This points to an unfolded protein response/ER quality-control theme, with oxidative stress management as a core feature. Some terms (viral process, transcription) may reflect broader connections but do not define the cluster.","confidence":"High","size":22,"edges":76,"triangles":119,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0034976","count":13},{"id":"GO:1903206","count":13},{"id":"GO:0045454","count":13},{"id":"GO:0034975","count":12},{"id":"GO:0016032","count":11}]},{"hash":"1604288518134154820","title":"Embryonic Development and Organogenesis","description":"These proteins are linked to broad developmental processes across multiple tissues (placenta, neural crest, forebrain/midbrain, pancreas, digestive tract), as well as patterning and transcriptional regulation. The GO terms cluster around multicellular development and organ morphogenesis, suggesting a general embryonic development/organogenesis theme rather than a single pathway.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":12},{"id":"GO:0090190","count":8},{"id":"GO:0001890","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0048557","count":7}]},{"hash":"235882009243998039","title":"Sensory GPCR Signaling and Temperature Response","description":"The top GO terms cluster around sensory signaling and GPCR pathways (pain perception, phototransduction, dopamine/adrenergic receptor signaling) along with temperature-related responses (temperature stimulus, thermogenesis) and related signaling components (cAMP, GTPase regulation). This suggests a cohesive module of GPCR-driven sensory signaling that ties temperature/pain responsiveness to broader sensory processes.","confidence":"Medium","size":22,"edges":185,"triangles":792,"max_degree":20,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0002024","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0007191","count":17},{"id":"GO:0043547","count":17}]},{"hash":"2167524917883652754","title":"Neuronal signaling and endocytosis with apoptosis regulation","description":"Top GO terms indicate a mix of signaling (GPCR, cAMP, GTPase, guanylyl cyclase), membrane trafficking (clathrin-mediated endocytosis), and neuronal-associated processes (sensory perception of sound, amyloid-beta formation) alongside apoptosis and immune modulation. The cluster seems to center on signaling and endocytic control with relevance to neural and immune contexts rather than a single narrow function, hence the chosen label. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006915","count":3},{"id":"GO:0045087","count":2},{"id":"GO:0019933","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0045953","count":2}]},{"hash":"306815690456648728","title":"Pain- and inflammation-associated vascular signaling","description":"This cluster is dominated by terms related to pain perception and inflammatory response, along with vascular regulation (positive regulation of blood pressure, vasoconstriction) and calcium signaling (release of sequestered calcium), plus GPCR and Rho signaling. Together these suggest a coherent theme of inflammatory processes tightly linked to vascular tone and Ca2+-mediated signaling. The electron transport chain and diet-induced thermogenesis may reflect metabolic state but do not override the vascular/inflammatory theme. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0010579","count":10},{"id":"GO:0022900","count":10},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10}]},{"hash":"77578424103571497","title":"GPCR Signaling and Vesicle Trafficking","description":"The cluster features GO terms tied to GPCR signaling, Rho-mediated signal transduction, cell migration, acrosome reaction, synaptic vesicle priming, and ER-Golgi ceramide transport, pointing to a common theme of signal transduction coupled with vesicle dynamics across diverse cell types (neuronal, reproductive, immune). Some terms are broader and less directly connected, but the core appears to be signaling pathways intertwined with vesicular processes.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007205","count":5},{"id":"GO:0035023","count":4},{"id":"GO:0016477","count":4},{"id":"GO:0007340","count":4},{"id":"GO:1901998","count":4}]},{"hash":"1080029381213328655","title":"GPCR-cAMP Signaling in Blood Pressure Regulation","description":"This cluster centers on GPCR pathways that activate adenylate cyclase and cAMP, including dopamine receptor signaling and prostaglandin responses, which tie to renin secretion and blood pressure control. The prominent terms\u2014adenylate cyclase-activating GPCR signaling, dopamine receptor signaling, prostaglandin response, and regulation of renin secretion\u2014point to a cardiovascular regulatory theme driven by GPCR signaling. Acknowledging related terms like peptide response and astrocyte chemotaxis, the core function remains GPCR-mediated signaling influencing cardiovascular physiology. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":22},{"id":"GO:0022900","count":22},{"id":"GO:0045777","count":22},{"id":"GO:0007191","count":21},{"id":"GO:1900135","count":21}]},{"hash":"1055825105717517495","title":"Cardiovascular and Nervous System Stimulus-Response Signaling","description":"This cluster spans signaling cascades (ERK, GTPase) and calcium dynamics, along with responses to pain, morphine, temperature, and thermogenesis, plus coagulation and heart development, suggesting a shared theme of diverse stimulus-induced signaling relevant to cardiovascular and nervous system contexts.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0070374","count":6},{"id":"GO:0007596","count":6},{"id":"GO:0043278","count":5},{"id":"GO:0043547","count":5},{"id":"GO:0042742","count":5}]},{"hash":"1179209353717184844","title":"Vascular smooth muscle differentiation","description":"The cluster shows strong representation of vasculogenesis and vascular-associated smooth muscle cell differentiation, with GO terms like vasculogenesis, vascular-associated smooth muscle cell differentiation, and positive regulation of TGF-beta receptor signaling. These, along with related terms such as regulation of integrin signaling and development of tissues that rely on smooth muscle, suggest a cohesive theme of vascular smooth muscle lineage specification and vessel development. An outlier term about amyloid-beta clearance is present but does not define the core function.","confidence":"High","size":22,"edges":9,"triangles":0,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:1900222","count":1},{"id":"GO:0001570","count":1},{"id":"GO:2001015","count":1},{"id":"GO:0001755","count":1},{"id":"GO:2000721","count":1}]},{"hash":"2187302367215009034","title":"Mitotic progression and ubiquitin-proteasome regulation","description":"This cluster centers on cell division and the mitotic cycle (cell division, cell cycle, mitotic cell cycle) plus proteostasis (proteasome regulatory particle assembly, protein ubiquitination). The convergence of these terms suggests a coherent theme of mitotic control coupled with targeted protein turnover. Some outlier terms (immune signaling, pinocytosis, cardiac signaling) may reflect broader multifunctionality or annotation noise, but do not obscure the main mitosis/proteostasis signal.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0051301","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070682","count":4}]},{"hash":"127768224535872411","title":"Unknown","description":"The top GO terms are diverse, covering neural signaling, ephrin/GPCR pathways, cardiac and vascular development, immune signaling, and general gene expression processes. There isn\u2019t a single cohesive function or theme that clearly ties all proteins together, so a specific label is not justifiable.","confidence":"","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900383","count":4},{"id":"GO:1901187","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0098907","count":4},{"id":"GO:0007275","count":3}]},{"hash":"247076318342545768","title":"Cardiac GPCR signaling and metabolic regulation","description":"The cluster prominently features adenylate cyclase-activating GPCR pathways (including dopamine receptor signaling), heart development and blood pressure regulation, mitochondrial electron transport, thermogenesis, and ERK/MAPK signaling, all pointing to GPCR-driven cardiovascular and metabolic control. Minor terms like defense response and pain perception may reflect multi-functional proteins or broader signaling roles, but the core theme centers on GPCR-mediated cardiovascular/metabolic signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0045777","count":14},{"id":"GO:0042742","count":13},{"id":"GO:0019233","count":13}]},{"hash":"352652114077076197","title":"Neuronal ion channels and neurotransmitter signaling","description":"Based on the top GO terms, the cluster centers on neuronal signal transduction: ion transmembrane transport (Na+, K+, Ca2+), excitatory postsynaptic potentials, and neurotransmitter pathways (GABA and serotonin receptor signaling). The sensory perception of sound term supports the auditory-neural signaling theme, while behavioral terms reflect downstream effects. ","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050910","count":19},{"id":"GO:0071805","count":19},{"id":"GO:0007214","count":19},{"id":"GO:0035725","count":19},{"id":"GO:0060079","count":19}]},{"hash":"1817710724089979888","title":"Endothelial angiogenesis and cardiac morphogenesis","description":"The cluster centers on vascular development and heart formation, with GO terms emphasizing VEGF signaling regulation, angiogenesis, endothelial cell differentiation/chemotaxis, and cardiac morphogenesis ( Notch signaling in heart field regulation, right atrium morphogenesis). The terms collectively point to endothelial/vascular processes and heart development, with supporting adhesion and remodeling roles.","confidence":"High","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900748","count":5},{"id":"GO:0016525","count":5},{"id":"GO:2001027","count":5},{"id":"GO:0032331","count":4},{"id":"GO:0051965","count":4}]},{"hash":"1178332640782142605","title":"Neural development and sensory perception","description":"The enriched GO terms cluster around nervous system development and sensory processes, including sensory perception of pain, cellular responses to temperature stimuli, visual learning, vestibular nucleus development, and general development/differentiation. Although there are a few outliers related to heart function and growth regulation, the dominant theme across the terms points to neural development and sensory signaling, giving a plausible, albeit modest, cohesive interpretation for the protein cluster. ","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":2},{"id":"GO:0002024","count":2},{"id":"GO:0071502","count":2},{"id":"GO:0007275","count":2},{"id":"GO:0008284","count":2}]},{"hash":"1331379984849581845","title":"Adipogenesis and Proliferation Signaling","description":"The cluster is enriched for fat cell differentiation and multicellular development, with co-occurring signals for mitotic cell cycle, intracellular signal transduction, calcium release, and ubiquitination, suggesting proteins coordinating adipocyte formation with growth and regulatory signaling.","confidence":"Medium","size":22,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045444","count":5},{"id":"GO:0051209","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0070431","count":4}]},{"hash":"1949552063354053351","title":"Tissue morphogenesis and remodeling","description":"This cluster centers on developmental remodeling across multiple tissues: bone formation and resorption (intramembranous ossification, bone resorption), lung morphogenesis with airway branching, epithelial tube branching, and neural development (neurogenesis-related processes). It also includes proteolytic and catabolic activity (proteolysis, bradykinin and neuropeptide catabolism), plus immune/reproductive remodeling signals (T cell cytotoxicity, decidualization). The shared theme is broad tissue morphogenesis and remodeling rather than a single pathway.","confidence":"Medium","size":21,"edges":52,"triangles":46,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0001957","count":9},{"id":"GO:0051603","count":9},{"id":"GO:0010815","count":9},{"id":"GO:0060441","count":9},{"id":"GO:0060448","count":9}]},{"hash":"282581387983304809","title":"Photoreceptor protein folding and trafficking","description":"This cluster is driven by terms related to protein quality control and folding (protein heterooligomerization; response to unfolded protein; ER-associated processes) and, importantly, protein localization to the photoreceptor outer segment, pointing to retina-specific processing of proteins, including assembly and transport to the photoreceptor compartments. Some terms (like steroid receptor assembly) are less coherent with retina specificity, but the strongest signal ties to photoreceptor protein folding/trafficking.","confidence":"High","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051291","count":11},{"id":"GO:0006986","count":10},{"id":"GO:1903546","count":10},{"id":"GO:0051301","count":10},{"id":"GO:0009938","count":10}]},{"hash":"1612878189194722262","title":"Ribosome biogenesis and translation","description":"Most top GO terms cluster around ribosome biology: cytoplasmic translation, ribosomal large subunit export from nucleus, ribosome biogenesis, and tRNA modification. These collectively point to components of ribosome assembly and protein synthesis; cell cycle terms likely reflect growth coupling rather than a separate pathway. The overall signal supports labeling the cluster as ribosome biogenesis and translation.","confidence":"High","size":21,"edges":63,"triangles":81,"max_degree":15,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000281","count":6},{"id":"GO:0051301","count":5},{"id":"GO:0002181","count":5},{"id":"GO:0000055","count":5},{"id":"GO:0007049","count":5}]},{"hash":"53155661527912371","title":"RNA splicing and translation regulation","description":"The proteins are enriched for post-transcriptional gene expression processes: regulatory ncRNA-mediated gene silencing, spliceosome-driven mRNA splicing, formation of the translation preinitiation complex, mRNA export from the nucleus, regulation of mRNA stability in stress, and regulation of translational initiation and reinitiation. This points to a cohesive role in RNA processing and translational control rather than a single pathway.","confidence":"High","size":21,"edges":54,"triangles":139,"max_degree":10,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:0001731","count":9},{"id":"GO:0045292","count":9},{"id":"GO:0006406","count":8}]},{"hash":"882955564692752204","title":"Platelet-mediated inflammation and angiogenesis","description":"The cluster is enriched for processes that link inflammation, coagulation, and vascular remodeling: IL-1\u2013driven responses, complement activation, collagen fibril organization, platelet activation and exocytosis, vasoconstriction, and angiogenesis. This suggests a cohesive module driving inflammatory vascular responses and new vessel formation.","confidence":"High","size":21,"edges":34,"triangles":12,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0045766","count":3},{"id":"GO:0071347","count":3},{"id":"GO:0006958","count":3},{"id":"GO:0001662","count":3}]},{"hash":"798459837875496251","title":"Ribosome Biogenesis and Translation Initiation","description":"The cluster\u2019s top GO terms are dominated by rRNA maturation (SSU/LSU/5.8S) and the formation of translation preinitiation complexes, plus translation reinitiation, which together point to ribosome biogenesis and early translation steps as the shared function. Some terms like transcription and histone methylation appear less directly related and may reflect annotation noise, but the core theme centers on ribosome assembly and initiation of protein synthesis.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0000462","count":5},{"id":"GO:0051567","count":5},{"id":"GO:0006351","count":5},{"id":"GO:0051301","count":5}]},{"hash":"852674056364729957","title":"Blood coagulation and vascular remodeling","description":"The top GO terms cluster around coagulation, plasminogen activation, and fibrinolysis, along with regulation of vasoconstriction and pulmonary artery morphogenesis, pointing to a vascular/hemostatic program. A subset of terms related to neuronal synapses is present but diminishes in prominence; overall, the shared theme appears to be coagulation and vascular remodeling rather than a single neuronal function. The absence of edges suggests the proteins are functionally related by these GO annotations rather than direct interactions in a network. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":9},{"id":"GO:0097150","count":8},{"id":"GO:0045907","count":8},{"id":"GO:0051968","count":8},{"id":"GO:0051919","count":8}]},{"hash":"318632846069940500","title":"Mitotic Cell Cycle and APC/C-Dependent Ubiquitination","description":"The GO terms point strongly to mitosis and cell-cycle control, including cell division, mitotic cell cycle, and anaphase-promoting complex-dependent catabolic process, plus K11-linked ubiquitination, which is a hallmark of APC/C-mediated proteolysis during mitosis. A few terms related to cilium assembly or neuronal differentiation appear less central, likely reflecting broader functional associations of these proteins, but the dominant signal is mitotic progression and ubiquitin-mediated regulation. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:2001162","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0006478","count":2}]},{"hash":"247970601448316383","title":"Ciliary Assembly and Mitotic Regulation","description":"Because the top GO terms cluster around ciliogenesis and photoreceptor outer segment localization, alongside mitotic cell cycle transitions, the proteins appear connected to ciliary biology and cell division; a few ER stress\u2013related translation terms seem secondary. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006478","count":10},{"id":"GO:0006986","count":9},{"id":"GO:1903546","count":9},{"id":"GO:0051301","count":9},{"id":"GO:0009938","count":9}]},{"hash":"120559395678240937","title":"Ribosome biogenesis and translation","description":"This cluster is dominated by GO terms for translation and ribosome biogenesis (including small subunit biogenesis) and mRNA decay, suggesting proteins function together in ribosome assembly and protein synthesis, with translations-specific processes like selenocysteine incorporation; some broader terms appear but do not outweigh the core theme.","confidence":"High","size":21,"edges":74,"triangles":79,"max_degree":12,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0007049","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0042274","count":3},{"id":"GO:0018108","count":3}]},{"hash":"1572587336076261239","title":"Ribosome biogenesis and translation","description":"The cluster\u2019s GO terms are dominated by translation, ribosome biogenesis, ribosomal subunit assembly, and rRNA processing (including snoRNP assembly and rRNA modification), indicating a cohesive module focused on producing and assembling ribosomes and carrying out protein synthesis. Some regulatory terms (JNK cascade, stringent response, selenocysteine incorporation) hint at translation regulation and specialized elongation/recoding, but the core theme remains ribosome production and function.","confidence":"Medium","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0000027","count":1},{"id":"GO:0006415","count":1},{"id":"GO:0015968","count":1},{"id":"GO:1904571","count":1}]},{"hash":"532187829254921945","title":"Blood coagulation and fibrinolysis regulation","description":"The top GO terms are dominated by blood coagulation, plasminogen activation, and positive regulation of fibrinolysis, pointing to a vascular coagulation/fibrinolysis module. Additional terms for inflammatory response and vasoconstriction reinforce a vascular/inflammatory theme; a few neural development/Notch-related terms may reflect secondary pleiotropy or cross-talk. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007596","count":16},{"id":"GO:0031639","count":16},{"id":"GO:0051919","count":16},{"id":"GO:0045746","count":13},{"id":"GO:0045907","count":13}]},{"hash":"588202458539267653","title":"Mitochondrial inheritance and ribosome biogenesis","description":"The top GO terms show strong signals for mitochondrial dynamics (inheritance, distribution, membrane organization) and ribosome-related processes (ribosomal subunit export from nucleus, ribosome biogenesis), suggesting a cluster focused on coordinating mitochondrial behavior with ribosome production during the cell cycle. Other terms like cell division and endocytic recycling support a broader cell-growth context, but the dominant shared theme is mitochondrial dynamics coupled with ribosome assembly.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0051301","count":15},{"id":"GO:0000055","count":14},{"id":"GO:0000001","count":13},{"id":"GO:0048312","count":13},{"id":"GO:0051932","count":13}]},{"hash":"1258596788908890222","title":"Neural signaling and retina development","description":"This cluster is enriched for neural and retinal functions, including dopamine receptor signaling, regulation of GTPase activity in signaling, retina development, astrocyte chemotaxis, and responses to signaling molecules like prostaglandins, suggesting a coherent theme of neural/retinal development and associated glial signaling. An outlier term related to renin secretion is present but does not override the dominant neural-retinal pattern.","confidence":"Medium","size":21,"edges":10,"triangles":3,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":15},{"id":"GO:0008283","count":15},{"id":"GO:0008284","count":15},{"id":"GO:0060041","count":15},{"id":"GO:0007191","count":14}]},{"hash":"1391110610453233080","title":"Unknown","description":"The GO terms are diverse and span hormone biosynthesis (testosterone, androgen), prostaglandin production, retina vascular development, mitochondrial protein import/insertion, and general regulation of cell proliferation, with little connectivity beyond a few biosynthetic processes. There\u2019s no clear, cohesive functional theme binding these proteins, so the cluster is best labeled Unknown with None confidence.","confidence":"","size":21,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":2},{"id":"GO:0061298","count":2},{"id":"GO:0008209","count":2},{"id":"GO:0001516","count":2},{"id":"GO:0008285","count":2}]},{"hash":"2193879890543208839","title":"Epigenetic Transcription Regulation","description":"The top GO terms point to regulation of gene expression at the transcriptional level (transcription by RNA polymerase II) and epigenetic marks (histone H3-K9 methylation) with phosphorylation as a regulatory layer. While a couple of terms reference development and chemical stress responses, the predominant theme ties to transcriptional control and epigenetic regulation, justifying this concise label.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":2},{"id":"GO:0045471","count":2},{"id":"GO:0021983","count":2},{"id":"GO:0060992","count":2},{"id":"GO:0021987","count":2}]},{"hash":"1596316364414651137","title":"Notch-regulated developmental patterning","description":"These proteins cluster around developmental processes across multiple tissues (follicle, intestinal, hypochord, segmentation, pattern specification) with a clear emphasis on Notch signaling regulation (positive and implied negative regulation). This suggests a core role in developmental patterning and cell fate decisions, despite some terms being tissue-specific or obsolete in older annotations.","confidence":"Medium","size":21,"edges":10,"triangles":1,"max_degree":4,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0001541","count":6},{"id":"GO:0002315","count":5},{"id":"GO:0060576","count":5},{"id":"GO:0036011","count":5},{"id":"GO:0045747","count":5}]},{"hash":"676159658987014872","title":"Glutamatergic Synaptic Plasticity and Signaling","description":"This cluster centers on neuronal communication and plasticity, highlighted by glutamatergic synaptic transmission and long-term potentiation terms. It also includes regulators of cytoskeletal and lipid signaling (Rho and sphingolipid biosynthesis) and apoptosis modulation, suggesting a module where synaptic activity and structural remodeling are balanced with cell survival cues, plus aging-related stress signals. Confidence: Medium.","confidence":"","size":21,"edges":173,"triangles":780,"max_degree":20,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0009738","count":6},{"id":"GO:0060291","count":6},{"id":"GO:0060963","count":6},{"id":"GO:0001324","count":6}]},{"hash":"1973695237972539544","title":"Cell division and intracellular trafficking","description":"GO terms point to mitotic processes (cell division, cell cycle, spindle assembly regulation, nuclear membrane reassembly) combined with membrane trafficking activities (intralumenal vesicle formation, multivesicular body assembly, Golgi retention) and mitochondrial protein targeting/insertion. This suggests a theme of coordinating organelle dynamics and membrane traffic during cell division, hence the label.","confidence":"High","size":21,"edges":53,"triangles":76,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0072321","count":3},{"id":"GO:0045039","count":3},{"id":"GO:0006626","count":3},{"id":"GO:0070676","count":3},{"id":"GO:1901673","count":3}]},{"hash":"1569209423592241579","title":"Unknown","description":"The terms span mitotic processes (centrosome cycle, spindle assembly), cell surface signaling and adhesion, lipid metabolism, and angiogenesis\u2014no clear shared function emerges across the cluster. Without a unifying theme, Unknown with confidence None is appropriate.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007098","count":1},{"id":"GO:0051225","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0002752","count":1},{"id":"GO:0007160","count":1}]},{"hash":"1589453120572678096","title":"Unknown","description":"The top GO terms are scattered across reproduction (embryo implantation, sperm capacitation), immune/inflammatory processes (leukocyte migration, granuloma formation), extracellular matrix remodeling (collagen catabolic process), and various signaling/regulatory activities (TGF-beta production, EGFR signaling). With no protein-protein edges and no dominant shared function among terms, there isn't a coherent theme to name a specific cluster, so Unknown with None confidence. ","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001202","count":1},{"id":"GO:0007566","count":1},{"id":"GO:1902492","count":1},{"id":"GO:0002633","count":1},{"id":"GO:2001268","count":1}]},{"hash":"163480595030921412","title":"Cell-surface signaling and angiogenesis regulation","description":"This cluster is enriched for terms tied to cell-surface signaling, including cell surface protein localization, cell surface receptor signaling, and activation of receptor tyrosine kinases, along with negative regulation of angiogenesis. The presence of cell-matrix adhesion and vascular permeability regulation reinforces a vascular-signaling theme; a few lipid/metabolic terms may reflect coordinated metabolic control associated with vascular processes. Overall, the items point to a coherent function around cell-surface signaling influencing angiogenesis and vascular regulation.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0034394","count":2},{"id":"GO:0048692","count":2},{"id":"GO:0043116","count":2},{"id":"GO:0032435","count":1},{"id":"GO:0051005","count":1}]},{"hash":"623667318591094618","title":"Pain-Sensory Processing and Drug Response","description":"The cluster is dominated by GO terms related to nociception and sensory perception (pain, regulation of pain perception) and drug- and stimulus-evoked responses (morphine, amphetamine), along with neural signaling themes such as cellular response to temperature, prostaglandin signaling, and modulation of glutamatergic transmission. This points to a cohesive group of proteins involved in nociceptive processing and pharmacological modulation in neural circuits, with ancillary ties to learning and sensorimotor gating processes.","confidence":"High","size":21,"edges":87,"triangles":88,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":18},{"id":"GO:0002024","count":17},{"id":"GO:0071502","count":17},{"id":"GO:0008542","count":15},{"id":"GO:0060134","count":14}]},{"hash":"855074625488270","title":"Developmental morphogenesis and axon guidance","description":"This cluster centers on tissue remodeling and organ morphogenesis (lung branching, heart looping) as well as cell adhesion and neural pathfinding (dopaminergic/serotonergic axon guidance) with Notch signaling regulation, indicating a cohesive theme of embryonic development and patterning, including neuronal wiring and organ formation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007155","count":2},{"id":"GO:0045746","count":2},{"id":"GO:0048771","count":2},{"id":"GO:0060490","count":2},{"id":"GO:0036514","count":2}]},{"hash":"2269740789070426036","title":"Vertebrate organogenesis","description":"This cluster is dominated by GO terms associated with embryonic development across multiple organs and tissues (pituitary gland, habenula, gonads, palate, cranial skeleton, ureteric bud branching), plus a general transcriptional activity term. The common theme is broad vertebrate organogenesis and morphogenesis rather than a single pathway, suggesting a developmental gene set.","confidence":"High","size":21,"edges":80,"triangles":52,"max_degree":14,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0021983","count":13},{"id":"GO:0003148","count":12},{"id":"GO:0021986","count":12},{"id":"GO:2000288","count":12},{"id":"GO:0008584","count":12}]},{"hash":"775755109124687915","title":"Regulators of GTPase and kinase signaling","description":"The top GO terms cluster around regulatory roles in signaling and enzyme activity (positive regulation of GTPase activity; positive/negative regulation of protein kinases and phosphorylation; regulation of calcium transporter activity; apoptotic regulation), suggesting these proteins function as modulators of signaling pathways rather than a single, cohesive process. Several terms are obsolete or peripheral, but the dominant theme is signaling regulation.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":12},{"id":"GO:0006469","count":11},{"id":"GO:1901896","count":9},{"id":"GO:0010800","count":9},{"id":"GO:0007568","count":8}]},{"hash":"312466437691926918","title":"Melanocyte Development and Migration Signaling","description":"The top GO terms cluster around melanocyte biology (KIT signaling pathway; melanocyte adhesion and migration) and broader developmental processes (multicellular organism development, planar polarity establishment). This suggests a program guiding melanocyte development, movement, and tissue organization, with accompanying signaling pathways. Confidence: High","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051092","count":12},{"id":"GO:0051965","count":11},{"id":"GO:0007275","count":11},{"id":"GO:0038109","count":10},{"id":"GO:0045425","count":10}]},{"hash":"697846077328178338","title":"Embryonic development and tissue differentiation","description":"The cluster's high-frequency terms span several organ systems (heart and vascular development, kidney tubule development, inner ear differentiation, immune cell differentiation) and include Notch signaling regulation and stem cell differentiation. This points to a common theme of developmental regulation and lineage specification across tissues, rather than a single pathway. ","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":17},{"id":"GO:0055114","count":16},{"id":"GO:0061156","count":14},{"id":"GO:0072017","count":14},{"id":"GO:0045608","count":14}]},{"hash":"764542931858097020","title":"Pain, Inflammation, and Opioid Signaling","description":"The cluster shows enrichment for neural pain processing and inflammatory pathways, including inflammatory response, sensory perception of pain, response to morphine, and negative regulation of glutamatergic transmission, plus prepulse inhibition which relates to sensory processing. While some terms are peripheral (lung tissue development, coagulation, kidney development, thermogenesis), the core theme ties to neural pain modulation and inflammatory signaling.","confidence":"Medium","size":21,"edges":20,"triangles":0,"max_degree":20,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":2},{"id":"GO:0019233","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0060427","count":2},{"id":"GO:0002024","count":2}]},{"hash":"2241310269926823750","title":"Neuronal GPCR Signaling and Neuropeptide Pathways","description":"The terms cluster around neural signaling: GPCR pathways (including dopamine receptor signaling), neuropeptide signaling, pain perception, and autonomic regulation (blood pressure, renin secretion), with astrocyte chemotaxis linking glial signaling; electron transport chain appears as a general cellular backdrop.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0035025","count":8},{"id":"GO:0045777","count":8},{"id":"GO:0007218","count":7}]},{"hash":"2216872691338726249","title":"GPCR Cardiovascular and Neural Signaling","description":"Proteins in this cluster are enriched for GPCR signaling terms, especially adenylate cyclase-activating GPCR pathways and dopamine receptor signaling, with connections to blood pressure regulation and renin secretion. Additional neural/astrocyte signaling and prostaglandin-related responses support a broader GPCR-driven signaling theme in cardiovascular and neural contexts, though a mitochondrial term (electron transport chain) introduces some noise. Overall, a GPCR-dominated signaling cluster with cardiovascular/neural context is suggested.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":18},{"id":"GO:0022900","count":18},{"id":"GO:0045777","count":18},{"id":"GO:0007191","count":17},{"id":"GO:1900135","count":17}]},{"hash":"864388519391196176","title":"Eye and craniofacial morphogenesis regulators","description":"This cluster is enriched for embryonic eye development terms (eye morphogenesis, retina development) and craniofacial morphogenesis (cranial skeleton morphogenesis, pituitary development) along with transcriptional regulation (RNA polymerase II) terms, suggesting a set of regulatory proteins coordinating early ocular and craniofacial development.","confidence":"High","size":21,"edges":132,"triangles":313,"max_degree":17,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":14},{"id":"GO:0048048","count":12},{"id":"GO:0060441","count":12},{"id":"GO:0043010","count":12},{"id":"GO:0000122","count":12}]},{"hash":"1459267828645217355","title":"Embryonic heart and neural development","description":"The cluster shows strong signals for heart-related organogenesis (heart and pulmonary myocardium development, organ induction) alongside neural development processes (neuron migration, olfactory bulb interneuron differentiation, locus ceruleus development, neuromuscular process), indicating a cohesive embryonic development theme spanning cardiac and neural tissues.","confidence":"High","size":21,"edges":41,"triangles":17,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0001759","count":11},{"id":"GO:0003350","count":11},{"id":"GO:0007507","count":11},{"id":"GO:0048701","count":11},{"id":"GO:0001764","count":11}]},{"hash":"1930642001667838965","title":"Collagen Remodeling and Development","description":"The top GO terms cluster around extracellular matrix remodeling (collagen fibril organization and collagen catabolic process) and developmental processes (endodermal differentiation, intramembranous ossification, oligodendrocyte differentiation), suggesting a theme of collagen-related ECM remodeling linked to development. Immune-related terms (complement activation via lectin pathway, B cell differentiation) are present but less dominant, indicating broader tissue-context signals. Overall, the dominant signal is collagen-associated remodeling paired with development, so the label reflects the primary pattern.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030199","count":3},{"id":"GO:0035987","count":3},{"id":"GO:0018996","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030574","count":2}]},{"hash":"963783572503886730","title":"Ubiquitin-Dependent Proteolysis and NF-kB Regulation","description":"This cluster is centered on ubiquitination-related processes (ubiquitin-dependent proteolysis, polyubiquitination) and NF-kappaB signaling (IKK activation), with related histone ubiquitination and apoptosis regulation terms. The strong representation of ubiquitination and NF-kB-related GO terms suggests proteins involved in ubiquitin-mediated protein turnover and signaling pathways controlling cell survival.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0000209","count":9},{"id":"GO:1903721","count":9},{"id":"GO:0070535","count":9},{"id":"GO:2000620","count":9}]},{"hash":"1368350987881860925","title":"Neural development and signaling","description":"The top GO terms center on neural development and synaptic activity (Schwann cell development, axonogenesis, visual perception, excitatory postsynaptic potential), with a few non-neural terms that are more general (mitotic cell cycle, apoptosis). This supports a label focused on neural development and signaling.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000086","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0060079","count":2},{"id":"GO:0007507","count":2}]},{"hash":"1548663191346064187","title":"Multiorgan Development","description":"The top GO terms point to development across several organs and tissues (forebrain, cerebellum, inner ear, placenta, visual system) and broad multicellular development, suggesting the cluster reflects general developmental programs rather than a single pathway or tissue-specific function.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0030900","count":4},{"id":"GO:0007275","count":4},{"id":"GO:0036120","count":3},{"id":"GO:0021549","count":3},{"id":"GO:0007601","count":3}]},{"hash":"1309820684699969682","title":"Neural development and synapse organization","description":"GO terms center on nervous system development, olfactory placode morphogenesis, and synapse organization, with supporting neuronal signaling features such as ion-channel clustering and cell\u2013cell adhesion, suggesting a cohesive theme of neural development and synaptic maturation. Peripheral terms like skeletal development and endothelial chemotaxis are less central to this cluster.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007399","count":4},{"id":"GO:0035584","count":3},{"id":"GO:0050925","count":3},{"id":"GO:0071699","count":3},{"id":"GO:0050808","count":3}]},{"hash":"2001232507551482203","title":"Prostaglandin-GPCR signaling in inflammation and platelets","description":"The top terms center on GPCR signaling (adenylate cyclase activation), prostaglandin E response, inflammatory processes, platelet activation, and TNF regulation, indicating a prostaglandin-mediated GPCR signaling module linked to inflammation and platelet function. Electron transport chain appears but is less central to the main theme.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0022900","count":13},{"id":"GO:0010579","count":12},{"id":"GO:0045777","count":12},{"id":"GO:0035025","count":10},{"id":"GO:0071380","count":10}]},{"hash":"13397941721456325","title":"Neural and Cardiac Development Signaling","description":"This cluster is enriched for both neural and cardiac developmental terms, including brain and cerebellar differentiation, right atrium morphogenesis, SA node action potential regulation, and heart-field signaling. It also features signaling pathways like Notch and ephrin, plus GPCR-related pathways, suggesting coordinated developmental signaling across neural and cardiovascular tissues.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0007420","count":2},{"id":"GO:1900383","count":2},{"id":"GO:0060843","count":2},{"id":"GO:0007205","count":2}]},{"hash":"529844392910663987","title":"MAPK/ERK Signaling in Differentiation","description":"The top GO terms cluster around ERK/MAPK signaling and differentiation processes (myotube and epithelial differentiation, MAPK cascade, and related regulation), with supporting signals like calcium entry and apoptotic regulation, suggesting a functional group focused on MAPK-driven differentiation and cell fate decisions.","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014902","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0051968","count":2},{"id":"GO:2000352","count":2},{"id":"GO:1902042","count":2}]},{"hash":"1658673366307832540","title":"Mechanotransduction and cytoskeletal stress signaling","description":"The cluster shows enrichment for mechanical stimulus response, stress fiber regulation, astral microtubule organization, ER unfolded protein response, and signaling processes such as extrinsic apoptotic signaling, STAT regulation, protein secretion, and gene expression. Together these terms point to a coordinated cellular stress response centered on sensing mechanical cues and remodeling the cytoskeleton, while linking proteostasis and signaling pathways. Therefore, the label mechanotransduction and cytoskeletal stress signaling is representative.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":3},{"id":"GO:0051497","count":2},{"id":"GO:0030953","count":2},{"id":"GO:2001241","count":2},{"id":"GO:0042518","count":2}]},{"hash":"58759891618010103","title":"Unknown","description":"Top terms span muscle development, protein turnover, immune signaling, viral latency, cell cycle, and plant metabolism, with no single, dominant shared function. This suggests a heterogeneous cluster without a clear unifying theme.","confidence":"","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0051260","count":4},{"id":"GO:0007519","count":3},{"id":"GO:0019046","count":3},{"id":"GO:0035853","count":3}]},{"hash":"277392643849395400","title":"Innate Immune Response and Apoptosis Cluster","description":"The top GO terms converge on innate immune processes (innate immune response; response to muramyl dipeptide) and apoptotic processes, indicating these proteins are linked to immune sensing and programmed cell death. Other terms mentioning mitotic cell cycle or telomere maintenance appear less central or represent broader regulatory connections, making innate immune signaling and apoptosis the most coherent theme. The absence of edges supports this as a functional annotation-based grouping rather than a physical interaction module.","confidence":"Medium","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0071276","count":4},{"id":"GO:0033138","count":3},{"id":"GO:0051973","count":3}]},{"hash":"1482062056703565153","title":"Golgi-Directed Protein Trafficking and Secretion","description":"Most of the top terms point to the Golgi apparatus and secretory trafficking (protein secretion; Golgi localization; Golgi-to-endosome and Golgi-to-plasma membrane transport). This indicates a cluster of proteins involved in the secretory pathway and Golgi-mediated transport, with additional related signaling and peptide-response terms that may reflect downstream effects of secretion. ","confidence":"High","size":21,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009306","count":1},{"id":"GO:0000042","count":1},{"id":"GO:0006895","count":1},{"id":"GO:0043001","count":1},{"id":"GO:0007191","count":1}]},{"hash":"899117791663190418","title":"Unknown","description":"The top GO terms span diverse processes: cell morphogenesis, proteasomal degradation, translation initiation and preinitiation complex formation, transcytosis, Wnt signaling, innate immune response, mitotic cell cycle, spliceosomal snRNP assembly, and even lipopolysaccharide biosynthesis. This scattered set lacks a single cohesive functional theme, suggesting the cluster is heterogeneous rather than representing one clear biological process.","confidence":"","size":20,"edges":82,"triangles":165,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0000902","count":2},{"id":"GO:0032436","count":2},{"id":"GO:0002188","count":2},{"id":"GO:0001731","count":2},{"id":"GO:0045056","count":2}]},{"hash":"565769805112124113","title":"Mitotic Cell Cycle Regulation and Ubiquitination","description":"The terms cluster around mitosis and cell division (mitotic cell cycle, anaphase-promoting complex\u2013dependent catabolic process, protein K11-linked ubiquitination) with ubiquitin-mediated proteolysis governing progression through mitosis (APC/C). Cadmium response and starvation are secondary stress signals, but the dominant theme is cell-cycle control via ubiquitination.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071276","count":3},{"id":"GO:2001162","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0061087","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1597842547978578768","title":"Nitrogen-containing compound metabolism","description":"The cluster\u2019s top GO terms cluster around nitrogen-containing substrates and turnover: L-glutamine metabolism, uracil catabolism, nicotinate/nicotinamide metabolism, creatinine catabolism, and nitrogen utilization, along with proteolysis. This points to a cohesive theme of processing nitrogenous compounds and amino/nucleic acid turnover, with a few peripheral terms that may reflect broader metabolic context.","confidence":"Medium","size":20,"edges":109,"triangles":334,"max_degree":18,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006541","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0006212","count":3},{"id":"GO:0019358","count":3},{"id":"GO:0006602","count":3}]},{"hash":"344165471518524769","title":"Lectin-pathway\u2013driven innate immune signaling","description":"The top GO terms cluster around complement activation via the lectin pathway, stimulatory C-type lectin receptor signaling, and Fc-gamma receptor signaling, together with responses to fungal origin and modulation of adhesion molecules, all pointing to lectin- and antibody-mediated innate immune signaling. Some kidney-development terms appear but are likely secondary to the dominant immune signaling theme; overall, the cluster is best described by lectin/receptor\u2013mediated innate immunity.","confidence":"High","size":20,"edges":87,"triangles":288,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":20},{"id":"GO:0071226","count":17},{"id":"GO:0060355","count":17},{"id":"GO:0072177","count":17},{"id":"GO:0002223","count":17}]},{"hash":"507147836781602843","title":"RNA Processing and Translation","description":"This cluster is dominated by GO terms for translation initiation and mRNA splicing (translation, initiation complex formation, spliceosomal assembly), pointing to RNA processing and protein synthesis roles. A few isolated terms about cell cycle and DNA integration appear as minor outliers, but the RNA-centric terms are the strongest signal.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006413","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0001732","count":1},{"id":"GO:0000387","count":1},{"id":"GO:2000825","count":1}]},{"hash":"2285037015257753631","title":"Unknown","description":"The GO terms are diverse, covering immune homeostasis, hypoxia response, auditory perception, RNA processing, unfolded protein response, calcium signaling, and lipid metabolism, with no single unifying theme and no edges linking the proteins, so no coherent cluster function can be assigned.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":3},{"id":"GO:0001666","count":3},{"id":"GO:0007605","count":3},{"id":"GO:1903799","count":2},{"id":"GO:0006986","count":2}]},{"hash":"583690110029998889","title":"Vascular development and neural crest migration","description":"This cluster is dominated by GO terms related to growth factor signaling (HGF receptor and VEGF receptor pathways) and arterial/vascular morphogenesis (coronary and renal arteries), plus neural crest\u2013related migration (ventral trunk neural crest, GnRH neuronal migration). Together they point to a cohesive theme of vascular development coordinated with neural crest\u2013driven cell migration and associated signaling, with a few additional developmental terms like paranodal junction assembly and ear development that are less central. Confidence: High","confidence":"","size":20,"edges":7,"triangles":3,"max_degree":4,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048012","count":6},{"id":"GO:0060982","count":6},{"id":"GO:0036486","count":5},{"id":"GO:0021828","count":5},{"id":"GO:0001868","count":5}]},{"hash":"838451842603237856","title":"Vitamin D Related Hormone Metabolism","description":"Top GO terms are dominated by vitamin D\u2013related processes: response to vitamin D, calcitriol biosynthetic process from calciol, and vitamin D catabolic process, indicating a core theme around vitamin D signaling and metabolism. Some other terms, such as female gonad/uterus development and brassinosteroid homeostasis, appear as peripheral or cross-kingdom associations, suggesting broader hormonal/metabolic regulation rather than a single cohesive pathway. Overall, the cluster seems anchored in vitamin D\u2013related metabolism with some outlier terms.","confidence":"Medium","size":20,"edges":20,"triangles":4,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":7},{"id":"GO:0008585","count":7},{"id":"GO:0060065","count":7},{"id":"GO:0010268","count":6},{"id":"GO:0071280","count":6}]},{"hash":"2016477733994515380","title":"Nuclear RNA processing and export regulation","description":"This cluster is enriched for terms related to the nuclear RNA life cycle: regulation of mRNA splicing, mRNA export, stabilization, and poly(A) tail regulation, along with small-subunit processome assembly, suggesting involvement in RNA processing and maturation within the nucleus. The common theme is control of RNA maturation and trafficking from transcription to translation, so the label reflects the core function of the cluster.","confidence":"Medium","size":20,"edges":155,"triangles":633,"max_degree":19,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":14},{"id":"GO:0048026","count":14},{"id":"GO:1902625","count":12},{"id":"GO:0034462","count":12},{"id":"GO:1901407","count":12}]},{"hash":"1795020403380362228","title":"Developmental transcription and organogenesis","description":"The cluster combines broad transcription-related GO terms (RNA polymerase II\u2013mediated transcription; DNA-templated transcription) with numerous development and organogenesis processes (somitogenesis, floor plate, lung vasculature, liver regeneration, lens epithelial proliferation, fat cell differentiation, vascular wound healing). This points to a set of proteins coordinating transcriptional regulation during embryonic development and tissue morphogenesis, rather than a single signaling pathway. ","confidence":"High","size":20,"edges":188,"triangles":1104,"max_degree":19,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":11},{"id":"GO:0035470","count":9},{"id":"GO:0006351","count":8},{"id":"GO:0071353","count":8},{"id":"GO:2001111","count":7}]},{"hash":"181344650889306449","title":"Retinoid and Steroid Hormone Metabolism with Lipid Signaling","description":"The cluster centers on lipid-derived signaling molecules, including retinol/retinal metabolism, prostaglandin biosynthesis, and androgen/testosterone biosynthesis/metabolism, plus signaling pathways like PI3K/AKT and calcium response. This suggests a cohesive theme of lipid-mediated hormone metabolism and signaling impacting cell proliferation and development.","confidence":"Medium","size":20,"edges":182,"triangles":1003,"max_degree":19,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0042572","count":9},{"id":"GO:0042574","count":9},{"id":"GO:0055114","count":7},{"id":"GO:0048661","count":6},{"id":"GO:0001516","count":6}]},{"hash":"2121532522027533710","title":"Inflammation and stress-response signaling","description":"Top GO terms cluster around inflammatory response, cortisol response, NF-kappaB signaling, and chemokine signaling regulation, with vasoconstriction and mechanotransduction cues. This suggests a core theme of immune/inflammatory pathways modulated by stress signals, despite a couple of broader or pleiotropic terms. Overall, the cluster appears best described by inflammation and stress-response signaling.","confidence":"Medium","size":20,"edges":3,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":13},{"id":"GO:0071260","count":11},{"id":"GO:0090260","count":10},{"id":"GO:0042346","count":10},{"id":"GO:0050929","count":10}]},{"hash":"669710137102380454","title":"Cytokine production and inflammasome regulation","description":"The GO terms point to inflammatory signaling: positive regulation of cytokine production (inflammatory response), IL-1\u03b2 production, cellular response to type II interferon, and especially positive regulation of NLRP3 inflammasome complex assembly, alongside negative regulation of IL-2 production. These suggest a coherent module focused on innate immune activation and cytokine-mediated inflammation, with some general cellular processes like Golgi organization and synaptic assembly appearing as supporting context rather than core drivers.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0007030","count":1},{"id":"GO:0051124","count":1},{"id":"GO:1900041","count":1},{"id":"GO:0051260","count":1},{"id":"GO:0071158","count":1}]},{"hash":"147461201390777870","title":"Steroid and lipid hormone metabolism","description":"The cluster centers on lipid- and sterol-derived hormone pathways, including prostaglandin biosynthesis, brassinosteroid homeostasis, and vitamin D-related processes (calcitriol biosynthesis and vitamin D response/catabolism), as well as related secondary metabolite and oxidative metabolism activities, suggesting a cohesive theme of lipid/sterol hormone metabolism with some detoxification links.","confidence":"Medium","size":20,"edges":70,"triangles":108,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0001516","count":11},{"id":"GO:0010268","count":8},{"id":"GO:0071280","count":8},{"id":"GO:0036378","count":8},{"id":"GO:2001037","count":8}]},{"hash":"1744842690134847935","title":"Unknown","description":"The top GO terms span diverse processes (steroid hormone biosynthesis/metabolism, plant brassinosteroid homeostasis, vitamin D metabolism, copper response, xenobiotic/alkaloid metabolism) with no clear, shared function tying all proteins together. The cluster shows very weak connectivity (one edge, no triangles), suggesting no cohesive functional module to name confidently.","confidence":"","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0061370","count":15},{"id":"GO:0008209","count":15},{"id":"GO:0010268","count":14},{"id":"GO:0071280","count":14},{"id":"GO:0036378","count":14}]},{"hash":"1113274988052564450","title":"Endothelial lipid transport and lipoprotein metabolism","description":"The top GO terms are dominated by endothelial activation and lipid-related processes (lipoprotein metabolic process and lipid transport), suggesting the cluster centers on lipid handling in endothelial cells. Mitochondrial-related terms are present but far less represented, likely secondary annotations. Thus, a lipid-transport/endothelium-centric label fits best.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042118","count":6},{"id":"GO:0042157","count":6},{"id":"GO:0006869","count":6},{"id":"GO:0000002","count":1},{"id":"GO:0030150","count":1}]},{"hash":"1962028717213948925","title":"Diverse solute transmembrane transporters","description":"The cluster is dominated by GO terms for transmembrane transport of a wide range of substrates, including xenobiotics, various ions (K+, Na+, phosphate, nitrite/nitrate), vitamins, and sugars (galactose), as well as related metabolic context (fucose). This pattern strongly suggests a group of membrane transporter proteins with broad substrate specificity, rather than a single substrate pathway. Confidence in this thematic label is High.","confidence":"","size":20,"edges":20,"triangles":1,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0006855","count":18},{"id":"GO:0071805","count":17},{"id":"GO:0035461","count":17},{"id":"GO:0015707","count":11},{"id":"GO:0035435","count":11}]},{"hash":"2134808513021303160","title":"GPCR-Driven Calcium-ERK Signaling","description":"These terms cluster around GPCR signaling that activates adenylate cyclase, PKC signaling, and the ERK1/2 cascade, coupled with regulation of cytosolic Ca2+. Additional terms point to vascular and endocrine outputs (blood pressure, coagulation, lymphangiogenesis, corticosterone secretion), suggesting proteins participate in GPCR-initiated signaling networks influencing vascular/hormonal regulation. The electron transport chain term is less connected but may reflect broader metabolic support for signaling proteins. Overall, the label GPCR-Driven Calcium-ERK Signaling captures the dominant functional theme.","confidence":"Medium","size":20,"edges":19,"triangles":0,"max_degree":19,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0070528","count":3},{"id":"GO:0071230","count":2}]},{"hash":"1159437724604205618","title":"Chondroitin sulfate proteoglycan biosynthesis","description":"The top GO terms are dominated by chondroitin sulfate proteoglycan biosynthetic processes, pointing to extracellular matrix proteoglycan production. Several terms also relate to ECM-associated functions such as regulation of epithelial cell proliferation in wound healing and modulation of signaling pathways that can influence tissue remodeling. A few other terms appear unrelated or obsolete, but the prevailing theme is proteoglycan biosynthesis and ECM remodeling. ","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050650","count":3},{"id":"GO:0030206","count":3},{"id":"GO:0006486","count":3},{"id":"GO:0075015","count":2},{"id":"GO:0005989","count":2}]},{"hash":"1487246891636597380","title":"Neuronal development and synaptic regulation","description":"The top GO terms centralize neural development and synaptic function (pyramidal neuron differentiation, axon guidance, long-term synaptic depression, signal transduction). While some terms relate to broader development, the neural-specific terms predominate, suggesting a cluster focused on neural differentiation and synaptic regulation. The absence of edges does not change the functional theme inferred from the GO annotations.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":3},{"id":"GO:0010467","count":2},{"id":"GO:0021859","count":2},{"id":"GO:0033564","count":2},{"id":"GO:0050728","count":2}]},{"hash":"1265949783611910885","title":"Vascular and hematologic oxidative stress responses","description":"The top GO terms point to oxidative stress responses (nitrosative stress, hydrogen peroxide) and vascular/hematologic biology (nitric oxide transport, blood vessel diameter maintenance, blood coagulation, erythrocyte differentiation), suggesting a theme at the intersection of redox biology with cardiovascular and blood cell processes; the additional terms are more general but can participate in signaling within these contexts.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051409","count":1},{"id":"GO:0043353","count":1},{"id":"GO:0050880","count":1},{"id":"GO:0010942","count":1},{"id":"GO:0042744","count":1}]},{"hash":"553579777749276313","title":"Neurovascular development","description":"The top GO terms span neural development (axon guidance, neural crest migration, GnRH neuron migration, paranodal junctions, synaptic vesicle endocytosis) and vascular/morphogen signaling (VEGF/HGF pathways, smooth muscle adhesion, renal artery morphogenesis), suggesting a cohesive role in coordinated neurovascular development; a minor immune-term is less central but can reflect developmental remodeling.","confidence":"Medium","size":20,"edges":28,"triangles":32,"max_degree":9,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:1900242","count":13},{"id":"GO:0048846","count":12},{"id":"GO:0048012","count":11},{"id":"GO:0036486","count":11},{"id":"GO:0021828","count":11}]},{"hash":"1984297282711277989","title":"Pain and Temperature Sensory Signaling","description":"This cluster centers on sensory perception of pain and cellular responses to temperature, supported by GPCR signaling, membrane potential regulation, phosphorylation, prostaglandin pathways, and energy metabolism (ETC). The inclusion of diet-induced thermogenesis and thermoregulatory responses suggests a neural/metabolic signaling module tied to noxious and thermal stimuli, with broader inflammatory signaling (macrophage chemotaxis) in related contexts. ","confidence":"Medium","size":20,"edges":116,"triangles":276,"max_degree":17,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":15},{"id":"GO:0002024","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0042391","count":11},{"id":"GO:0008542","count":11}]},{"hash":"1181559904303103130","title":"Atrial development and conduction proteins","description":"The top GO terms point to atrial cardiac muscle cell action potential, SA node communication, atrial septum development, and protein localization relevant to cardiac muscle membranes and T-tubules, suggesting a cluster focused on atrial development and electrical conduction. Some neuron-related terms appear but the cardiac-related terms are predominant, supporting this interpretation. Confidence: Medium","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":3},{"id":"GO:0086014","count":3},{"id":"GO:0007432","count":3},{"id":"GO:0021859","count":3},{"id":"GO:0036371","count":2}]},{"hash":"2202554766846768939","title":"Dopaminergic GPCR signaling and synaptic regulation","description":"The dominant GO term is dopamine receptor signaling that activates adenylate cyclase, with related terms for dopamine uptake, GPCR signaling, and downstream GTPase activity. Additional terms involve prostaglandin response and astrocyte chemotaxis, suggesting neuromodulatory signaling across neurons and glia. This supports a cohesive theme of dopaminergic GPCR pathways modulating synaptic function, hence this label.","confidence":"High","size":20,"edges":10,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":17},{"id":"GO:1900135","count":17},{"id":"GO:2000458","count":17},{"id":"GO:1901652","count":17},{"id":"GO:0018298","count":17}]},{"hash":"690731807251981412","title":"Death receptor\u2013mediated apoptosis and necroptosis signaling","description":"Proteins in this cluster repeatedly map to extrinsic apoptotic signaling via death receptors, necroptotic pathways, TNF responses, and type I interferon signaling, indicating a cohesive theme of immune-cell death and antiviral signaling. Decidualization and thymus development terms suggest contextual roles, but the dominant pattern centers on death-receptor\u2013driven apoptosis and necroptosis with interferon involvement.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046697","count":4},{"id":"GO:0043029","count":3},{"id":"GO:0019050","count":3},{"id":"GO:0060340","count":3},{"id":"GO:0097192","count":3}]},{"hash":"1150602968399004591","title":"Synaptic development and plasticity signaling","description":"The cluster is enriched for GO terms related to neuron development and synaptic connectivity, such as synapse assembly, dendritic spine morphogenesis, long-term potentiation, axon fasciculation, integrin signaling, and MAPK cascades, suggesting roles in synaptic development and plasticity. Some terms (DNA replication, telomere maintenance) reflect general cellular maintenance but do not override the neural focus of the dominant terms.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0006260","count":3},{"id":"GO:0051965","count":3},{"id":"GO:0000196","count":2},{"id":"GO:0007232","count":2}]},{"hash":"1254964459406873269","title":"Vascular development and remodeling","description":"This cluster centers on terms tied to blood vessel biology: pulmonary artery morphogenesis, endothelial cell chemotaxis, smooth muscle cell migration and proliferation, cellular response to mechanical stimulus, and blood coagulation, suggesting a module involved in vascular development and remodeling. Some terms (e.g., skeletal system development, gephyrin clustering) appear less related and may reflect annotation noise or multifunctionality, but the dominant signal points to vascular processes.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0001501","count":7},{"id":"GO:0048661","count":7},{"id":"GO:2001027","count":7},{"id":"GO:0007596","count":7}]},{"hash":"738655740577362822","title":"Developmental Morphogenesis and Cell Cycle Processes","description":"The terms point to tissue and organ development (hair follicle placode, papilla formation, root development) with cell movement and division (migration, chromatid separation, centromere cohesion); GTPase activity regulation ties these processes to cytoskeletal dynamics, while nuclear import relates to general cell-cycle control during development.","confidence":"Medium","size":20,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":6},{"id":"GO:0016477","count":6},{"id":"GO:0048364","count":6},{"id":"GO:0006607","count":6},{"id":"GO:0051306","count":5}]},{"hash":"1610061976746538106","title":"Intracellular signaling and innate immune response","description":"The top GO terms emphasize intracellular signal transduction and immune-related pathways (defense to virus, NOD2 signaling, IL-12 regulation), suggesting the proteins largely participate in signaling cascades that modulate innate immunity. While there are additional terms covering mRNA processing, telomere maintenance, and endothelial/neuronal contexts, the dominant theme is signaling in immune-related pathways with related gene expression regulation.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0035556","count":4},{"id":"GO:0051607","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0070431","count":3}]},{"hash":"660139282935361935","title":"Unknown","description":"Top terms span DNA replication, methylation, mRNA processing, ubiquitin-dependent proteolysis, immune signaling, neuronal synaptic regulation, and endothelial differentiation, with no clear shared function. As no common theme emerges, the cluster should be labeled Unknown.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006260","count":2},{"id":"GO:0032259","count":1},{"id":"GO:0010038","count":1},{"id":"GO:1900383","count":1},{"id":"GO:0042787","count":1}]},{"hash":"304638098361411655","title":"Neuronal signaling and sensory perception","description":"This cluster's top GO terms cluster around neural signaling and sensory processes\u2014dopaminergic synaptic transmission, visual perception and learning, and behavioral responses to cocaine\u2014indicating a core theme of neuronal communication and sensory processing, with some developmental and immune-related annotations appearing less central.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0071380","count":3},{"id":"GO:0001707","count":3},{"id":"GO:0001963","count":3},{"id":"GO:0007601","count":3}]},{"hash":"1435049313073123992","title":"Neural GPCR Signaling and Autonomic Regulation","description":"GPCR signaling (adenylate cyclase pathways, dopamine receptors) aligns with pain and temperature sensing and autonomic cardiovascular control (blood pressure, renin). Together, these terms reflect neural regulation of sensory and cardiovascular functions.","confidence":"High","size":20,"edges":4,"triangles":1,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0042391","count":12},{"id":"GO:0010579","count":12}]},{"hash":"404107070139107771","title":"Coagulation and wound healing with ossification","description":"Top GO terms indicate strong involvement in blood coagulation, regulation of plasminogen activation and fibrinolysis, and wound healing, with intramembranous ossification also represented, suggesting bone remodeling during tissue repair. Some terms related to ion transport and signaling appear as noise but do not override the coagulation/wound-healing theme.","confidence":"High","size":20,"edges":72,"triangles":103,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042220","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0010757","count":2},{"id":"GO:0051918","count":2},{"id":"GO:0044319","count":2}]},{"hash":"806977035330055536","title":"Biosynthesis and Methylation Pathways","description":"The cluster's GO terms center on diverse biosynthetic processes (antibiotic, biotin, cobalamin, vitamin E) and multiple RNA/protein modification steps (tRNA methylation, rRNA modification, mRNA capping, histone and N-terminal methylation). Although nodulation appears, the dominant theme is biosynthesis paired with methylation/modification activities, suggesting a broad metabolic/machinery set rather than a single pathway.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":12},{"id":"GO:0009102","count":12},{"id":"GO:0030488","count":9},{"id":"GO:0018012","count":9},{"id":"GO:0000154","count":9}]},{"hash":"612131492649114506","title":"Neural signaling and developmental regulation","description":"These proteins cluster around signaling processes involved in neural communication (neurotransmitter secretion), neural development (retinal axon guidance, Notch pathway regulation), and broader developmental cues (FSH response, mesangial cell development, ECM remodeling via hyaluronan), suggesting a theme of signaling modulation during development and maturation across tissues.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007269","count":7},{"id":"GO:0071372","count":7},{"id":"GO:0055114","count":7},{"id":"GO:0045746","count":7},{"id":"GO:0043154","count":6}]},{"hash":"6240386112915571","title":"Secretory vesicle exocytosis and secretion","description":"The cluster centers on vesicle trafficking and exocytosis, evidenced by terms for synaptic vesicle priming and presynaptic dense core vesicle exocytosis, and insulin secretion in response to glucose, indicating coordinated secretion in neurons and endocrine cells. Additional GTPase regulation supports vesicle trafficking, while xenobiotic and inflammatory signals suggest broader stress-responsive pathways accompanying secretion. Overall, secretory vesicle mobilization and exocytosis best tie these functions together.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0042493","count":3},{"id":"GO:0046512","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0071322","count":3},{"id":"GO:0016082","count":3}]},{"hash":"2281786414818567781","title":"Ubiquitin signaling in innate antiviral response","description":"The top GO terms point to ubiquitin-dependent protein turnover and multiple ubiquitination types (K63, K6, linear), along with autoubiquitination, and intertwined innate immune defenses including NF-kappaB signaling and defense against virus. This suggests a cohesive role in ubiquitin-mediated immune signaling, particularly antiviral responses.","confidence":"High","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0045087","count":9},{"id":"GO:0051607","count":9},{"id":"GO:1903265","count":8},{"id":"GO:0036205","count":8}]},{"hash":"1043795217333967611","title":"Rho/Ras GTPase Cytoskeleton Dynamics","description":"The cluster is dominated by GO terms for regulation/activation of Rho and Ras signaling and for microspike/filopodium assembly, pointing to actin cytoskeleton remodeling driven by small GTPases. While a few catabolic and transcription terms appear, the shared theme is cytoskeletal dynamics linked to GTPase signaling.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0030035","count":2},{"id":"GO:0046847","count":2},{"id":"GO:0009253","count":2},{"id":"GO:0016998","count":2}]},{"hash":"1621406513478381427","title":"Unknown","description":"The top GO terms are highly disparate (skeletal muscle development and fiber formation; ubiquitin-dependent protein catabolic process; B and T cell signaling; plus unrelated terms like gravitropism and an obscure developmental term), suggesting a heterogeneous set of functions with no single coherent theme. The absence of edges and the presence of obsolete terms further indicate noise or misannotation rather than a true, functionally cohesive cluster. Confidence in a unique functional label is therefore None.","confidence":"","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":11},{"id":"GO:0007519","count":8},{"id":"GO:0032764","count":8},{"id":"GO:0050853","count":8},{"id":"GO:0009958","count":8}]},{"hash":"1334990513757874542","title":"Endothelial Adhesion and Vascular Development","description":"Many top terms center on blood vessel formation, endothelial cell\u2013cell adhesion, and coagulation (ventricular septum development, endothelial adhesion, smooth muscle migration, blood coagulation). A few terms lie outside this theme (osteoblast differentiation, hyaluronan biosynthesis), but the dominant pattern is vascular/endothelial function and development.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0014909","count":6},{"id":"GO:0003281","count":6},{"id":"GO:0071603","count":6},{"id":"GO:0007596","count":6},{"id":"GO:2001027","count":6}]},{"hash":"1540107390755119095","title":"Neural signaling and synapse regulation","description":"This cluster shows enrichment in neural-related terms: sensory perception of sound, regulation of grooming behavior, serotonin uptake, and opioid receptor signaling, along with synapse organization and receptor clustering. There are also signaling-related terms (Wnt regulation) and vesicle formation that can tie to synaptic vesicle trafficking. While some terms are unrelated (immune and cell wall processes), the strongest theme centers on neuronal signaling and synaptic function.","confidence":"Medium","size":20,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0030111","count":2},{"id":"GO:0051612","count":1},{"id":"GO:0070676","count":1},{"id":"GO:0043113","count":1}]},{"hash":"1920589535451380769","title":"Spliceosome and RNA Processing Machinery","description":"The cluster is dominated by GO terms for mRNA splicing via spliceosome, spliceosomal complex assembly, and snRNP assembly, along with tRNA processing and maturation of SSU-rRNA, indicating core RNA processing functions. P-body assembly further supports RNA metabolism and mRNA turnover, making RNA splicing/maturation the central theme; stress response terms are present but less defining. ","confidence":"High","size":19,"edges":167,"triangles":904,"max_degree":18,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0045292","count":11},{"id":"GO:0008033","count":11},{"id":"GO:0042633","count":10},{"id":"GO:0000245","count":10},{"id":"GO:0070317","count":10}]},{"hash":"1268865342945834999","title":"Neural and sensory development","description":"These proteins\u2019 top GO terms cluster around developmental and differentiation processes, especially in neural and sensory systems: DNA-templated transcription indicates developmental gene regulation; retina vasculature morphogenesis, neuromast hair cell differentiation, and axonal fasciculation point to sensory organ formation and neural connectivity; neuronal commitment to forebrain neuron types shows neural specification; behavioral fear response reflects neural network outcomes. Some terms (parathyroid gland development, type II pneumocyte differentiation) are broader developmental processes, but the core pattern supports a neural/sensory development theme. Confidence: Medium","confidence":"","size":19,"edges":4,"triangles":0,"max_degree":3,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0061299","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0048903","count":3},{"id":"GO:0007413","count":3}]},{"hash":"1534922395958514624","title":"Neuronal receptor signaling and synapse regulation","description":"The top GO terms cluster around receptor clustering, synapse organization, and regulation of neurotransmitter pathways (serotonin uptake, opioid signaling), plus behavioral relevance (regulation of grooming behavior). These together point to a module centered on neural signaling and synaptic maintenance, even though a few terms touch on immune or bone processes; the neural signaling theme is the strongest signal across the set.","confidence":"Medium","size":19,"edges":78,"triangles":124,"max_degree":15,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0043113","count":8},{"id":"GO:2000821","count":8},{"id":"GO:0046328","count":7},{"id":"GO:0070433","count":6},{"id":"GO:0003016","count":5}]},{"hash":"1571705029574962385","title":"Nuclear mRNA processing and stability","description":"This cluster shows strong representation of GO terms for mRNA splicing, export from the nucleus, stabilization, and poly(A) tail regulation, plus processome-related assembly, pointing to a cohesive role in nuclear mRNA maturation and turnover.","confidence":"High","size":19,"edges":69,"triangles":104,"max_degree":13,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":8},{"id":"GO:0045292","count":8},{"id":"GO:1902625","count":7},{"id":"GO:0034462","count":7},{"id":"GO:1901407","count":7}]},{"hash":"165991771716431726","title":"Cell-surface immune and vascular signaling","description":"These proteins cluster around immune recognition at the cell surface, interfaces with coagulation/fibrinolysis (complement activation, plasminogen activation, fibrinolysis), and vascular remodeling (angiogenesis, cell-matrix adhesion, receptor signaling). The recurring theme is surface-based immune/coagulation signaling linked to vascular remodeling; some lipid metabolism terms are less central.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":5},{"id":"GO:0034394","count":4},{"id":"GO:0042730","count":4},{"id":"GO:0031639","count":4},{"id":"GO:0045766","count":4}]},{"hash":"1600974751350536428","title":"Unknown","description":"The Top Terms cover a wide range of functions: regulation of GTPase activity and kinase activity, phosphorylation, cell division, brain development, innate immune response, ubiquitination, histone methylation, and stress responses (cadmium). This diversity suggests no single cohesive function ties all proteins together, so a specific, representative label is not \u0642\u0627\u0628\u0644. ","confidence":"","size":19,"edges":27,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0016310","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0006469","count":2}]},{"hash":"1885577154262446864","title":"Microtubule Cytoskeleton Dynamics and Transport","description":"Cluster terms cluster around microtubule-based processes: plus- and minus-end directed transport, cytoskeleton polarity, microtubule depolymerization, cell division-related events, and junction maintenance linked to the cytoskeleton. Some neuron/brain-specific terms extend the theme to neuronal cytoskeleton and organization, but the unifying thread is microtubule dynamics and transport across cellular contexts.","confidence":"High","size":19,"edges":49,"triangles":64,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0000742","count":10},{"id":"GO:1990942","count":9},{"id":"GO:0045218","count":9},{"id":"GO:0031534","count":9},{"id":"GO:1990535","count":9}]},{"hash":"103010924551963922","title":"Mitochondrial Transport and Dynamics","description":"The cluster shows multiple mitochondrial-related processes: transport of metabolites and cofactors (ATP, citrate, CoA, manganese, phosphate) across mitochondrial membranes, regulation of mitochondrial membrane potential, and mitochondrial membrane fission, along with apoptotic mitochondrial changes and even an old GO term referring to mitochondrial genome maintenance. Together, these point to a cohesive theme of mitochondrial membrane transport and structural/dynamic regulation.","confidence":"High","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0032869","count":4},{"id":"GO:0000002","count":4},{"id":"GO:0035435","count":3},{"id":"GO:0008637","count":3},{"id":"GO:0006828","count":3}]},{"hash":"1596211399187541547","title":"Fatty acid biosynthesis and transport","description":"The cluster is enriched for GO terms centered on fatty acid production, modification, and uptake\u2014such as fatty acid biosynthetic process, long-chain fatty acid metabolic process, medium-chain fatty-acyl-CoA metabolic process, and long-chain fatty acid import across the plasma membrane\u2014suggesting a core theme of fatty acid metabolism and transport. Some terms (seed coat development, lipoteichoic acid biosynthetic process, bile acid metabolism, bioluminescence) reflect broader or organism-specific lipid-related functions but do not override the dominant fatty acid signal.","confidence":"Medium","size":19,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006633","count":5},{"id":"GO:0010214","count":4},{"id":"GO:0001676","count":4},{"id":"GO:0036112","count":4},{"id":"GO:0015911","count":4}]},{"hash":"101927505518591416","title":"Neural and vascular development signaling","description":"The GO terms point to core developmental signaling pathways (Robo/roundabout and Hedgehog/Smoothened) that govern nervous system development (axon guidance, synapse organization) as well as vascular and organ development (angiogenesis, kidney development) and even muscle differentiation. This suggests a shared theme of developmental signaling orchestrating multiple lineage programs, especially neural and vascular patterning, hence the chosen label. ","confidence":"High","size":19,"edges":138,"triangles":497,"max_degree":17,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035385","count":5},{"id":"GO:0007224","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0007399","count":5}]},{"hash":"725878343359602349","title":"Pollen exine formation and anther development","description":"The cluster top terms strongly point to pollen wall formation (pollen exine) and anther dehiscence, core aspects of plant reproductive development. Additional terms like N-linked glycosylation and Arp2/3 actin nucleation suggest supportive roles in protein processing and cytoskeletal remodeling during pollen development. Overall, the dominant theme is pollen development with exine formation, with related metabolic and cytoskeletal processes.","confidence":"High","size":19,"edges":170,"triangles":952,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0006487","count":4},{"id":"GO:0046712","count":4},{"id":"GO:0010584","count":4},{"id":"GO:0071405","count":4},{"id":"GO:0046032","count":4}]},{"hash":"1779188350876077009","title":"DNA replication and cell cycle regulation","description":"This cluster is dominated by GO terms for DNA replication, centrosome cycle, and regulation of nuclear DNA replication, indicating a core focus on cell cycle control. While there are additional terms related to development and signaling, the strongest and most consistent signal lies in replication and centrosome dynamics, supporting a label around DNA replication and cell cycle regulation.","confidence":"High","size":19,"edges":85,"triangles":141,"max_degree":17,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":19},{"id":"GO:0007098","count":19},{"id":"GO:0048701","count":19},{"id":"GO:0010571","count":19},{"id":"GO:0071333","count":18}]},{"hash":"1379038172246946419","title":"Hematopoiesis and leukocyte signaling via integrins","description":"Based on the prominent GO terms, the proteins cluster around hematopoietic development (hemopoiesis), leukocyte chemotaxis, B cell differentiation, and signaling pathways centered on integrins, PDGF, and Kit\u2014together pointing to immune cell development, adhesion, and signaling. The repeated emphasis on cell-matrix adhesion and integrin signaling supports this as the core theme. The term for vagina development appears as a potential annotation artifact and does not align with the main theme.","confidence":"Medium","size":19,"edges":33,"triangles":8,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001954","count":17},{"id":"GO:0002688","count":17},{"id":"GO:0060068","count":17},{"id":"GO:0033138","count":17},{"id":"GO:0030097","count":17}]},{"hash":"1215407427751153829","title":"Cocaine-responsive neuronal signaling and development","description":"The cluster shows strong enrichment for neural development terms (hippocampus development, regulation of axonogenesis) and signaling pathways (Wnt, JNK, PI3K-related activity, protein stability), plus a specific response to cocaine, suggesting a cohesive theme of neuronal signaling and development modulated by drug response. Some terms like mitotic cell cycle are more general background, but the neural-focused terms dominate.","confidence":"High","size":19,"edges":19,"triangles":6,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":16},{"id":"GO:0033138","count":15},{"id":"GO:0042220","count":15},{"id":"GO:0050771","count":15},{"id":"GO:0043552","count":15}]},{"hash":"983452451379618642","title":"Germ cell development and RNA metabolism","description":"This cluster is driven by germ-line processes (male germ-line cyst formation and spermatocyte division), indicating a focus on spermatogenesis. The accompanying RNA biology terms\u2014mRNA export, stabilization, poly(A) tail regulation, and regulatory ncRNA\u2013mediated gene silencing, plus small-subunit processome assembly\u2014suggest coordinated RNA processing and regulation supporting germ cell development. The combination points to a coherent theme of male germ cell formation with linked RNA metabolism and ribosome biogenesis.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048136","count":2},{"id":"GO:0048137","count":2},{"id":"GO:1902625","count":1},{"id":"GO:0034462","count":1},{"id":"GO:1901407","count":1}]},{"hash":"2180592023951228380","title":"Neuronal Ion Transport and Synaptic Signaling","description":"The top GO terms cluster around transmembrane transport of K+, Na+, and Ca2+, indicating ion channel activity and membrane excitability, coupled with neurotransmitter signaling via GABA and serotonin pathways and excitatory postsynaptic potentials. The inclusion of behavioral terms such as locomotory behavior, startle response, conditioned taste aversion, and circadian sleep/wake cycle regulation suggests these proteins participate in neuronal circuits governing behavior and sleep patterns. Together, they point to a cohesive group involved in neuronal signaling, ion homeostasis, and related behaviors.","confidence":"High","size":19,"edges":28,"triangles":13,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":18},{"id":"GO:0007214","count":17},{"id":"GO:0035725","count":17},{"id":"GO:0060079","count":17},{"id":"GO:0001661","count":17}]},{"hash":"2234205685707744088","title":"Synaptic vesicle trafficking and SNARE exocytosis","description":"These GO terms cluster around secretory trafficking from the ER through the Golgi, SNARE complex assembly, and vesicle fusion, including exocytic insertion of neurotransmitter receptors at the postsynaptic membrane and links to synaptic plasticity. The combination of Golgi transport, vesicle dynamics, and receptor trafficking strongly supports a synaptic vesicle\u2013exocytosis theme.","confidence":"High","size":19,"edges":49,"triangles":44,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":7},{"id":"GO:0060291","count":6},{"id":"GO:0006891","count":6},{"id":"GO:0090161","count":6},{"id":"GO:0048280","count":6}]},{"hash":"1352096496094612831","title":"Zinc ion transport and homeostasis","description":"The cluster is dominated by GO terms related to zinc biology: zinc import across membranes, intracellular zinc ion homeostasis, detoxification of zinc, and cellular response to zinc starvation, plus zinc ion transport across the plasma membrane. While there are a couple of outliers (limb development and mitochondrial respirasome assembly), the strongest signals point to zinc import/transport and overall zinc homeostasis.","confidence":"High","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":null,"top_go_terms":[{"id":"GO:0034224","count":1},{"id":"GO:0070574","count":1},{"id":"GO:0060173","count":1},{"id":"GO:0010312","count":1},{"id":"GO:0006831","count":1}]},{"hash":"406450148360232020","title":"Carbohydrate biosynthesis and sugar metabolism","description":"The cluster\u2019s top GO terms are dominated by biosynthetic and metabolic processes involving sugars and their derivates\u2014glycogen, starch, sucrose, glycolipids, and bacillithiol\u2014suggesting a central theme of carbohydrate biosynthesis and sugar metabolism across organisms. A few terms like response to flooding and feeding behavior appear peripheral, but they do not overturn the primary carbohydrate-focused signal.","confidence":"Medium","size":19,"edges":19,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0009413","count":5},{"id":"GO:0005978","count":5},{"id":"GO:0009247","count":5},{"id":"GO:0072708","count":5},{"id":"GO:0071793","count":5}]},{"hash":"1817117526302075743","title":"PKC-Driven Immune Signaling and Membrane Organization","description":"This cluster is driven by GO terms tied to protein kinase C signaling, IL-2 production, and establishment of T cell polarity, along with protein localization to membrane rafts. These together point to immune-cell signaling and membrane-associated signaling platforms. Other terms about ERAD, cholesterol regulation, and podocyte development suggest broader cellular contexts, but the strongest common theme centers on PKC-mediated signaling and membrane organization in immune-related processes.","confidence":"Medium","size":19,"edges":33,"triangles":18,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0070528","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0060355","count":3},{"id":"GO:0045541","count":3},{"id":"GO:0001302","count":3}]},{"hash":"725823697466496783","title":"Developmental cell adhesion and migration signaling","description":"This cluster converges on developmental processes (heart development, axis specification) and on cell-adhesion and migration pathways (integrin signaling, Rho regulation, adhesion-dependent spreading, fibroblast migration), with additional signaling roles (insulin receptor signaling, calcium channel regulation) that together point to coordinated cellular movement and tissue formation during development.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0007313","count":3},{"id":"GO:0007229","count":3},{"id":"GO:0018996","count":3},{"id":"GO:0010748","count":2}]},{"hash":"1446852889587655062","title":"Unknown","description":"Unknown","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032968","count":2},{"id":"GO:0006370","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0045214","count":2},{"id":"GO:0000447","count":1}]},{"hash":"1351534244219211864","title":"Neural development and axon guidance cluster","description":"Most of the top GO terms point to neural development and connectivity, with radial glial scaffold formation, forebrain radial glial differentiation, and axon guidance being prominent. While there are also terms tied to other developmental processes (endothelial chemotaxis, pancreas development, spermatid differentiation) and cytoskeletal/trafficking roles (GTPase regulation, stress fiber assembly, Golgi localization), the neural development signals predominate, supporting a name focused on neural development and axon guidance.","confidence":"Medium","size":19,"edges":8,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0021943","count":4},{"id":"GO:0021861","count":3},{"id":"GO:0007289","count":3},{"id":"GO:0035767","count":3},{"id":"GO:0031018","count":3}]},{"hash":"724111846412843212","title":"Nuclear mRNA Deadenylation-Dependent Decay","description":"The top GO terms are dominated by deadenylation-dependent decay and related nuclear mRNA catabolic processes, indicating a coherent theme of RNA turnover in the nucleus. Although there are a few outlier terms (DNA repair, steroid biosynthesis), the RNA decay signals are the strongest, justifying a label focused on nuclear mRNA degradation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006281","count":1},{"id":"GO:0006351","count":1},{"id":"GO:0006694","count":1},{"id":"GO:2000757","count":1},{"id":"GO:0090503","count":1}]},{"hash":"1089709745192757429","title":"Neural Development and Signaling","description":"This cluster is dominated by brain development and synaptic vesicle priming terms, with supporting signals from phosphatidylinositol pathways and NF-kappaB signaling, pointing to neuronal development and synaptic communication roles. Other terms (membrane repair, innate immunity) may reflect broader cellular maintenance but do not outweigh the neural-focused cues.","confidence":"High","size":19,"edges":126,"triangles":393,"max_degree":17,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0016525","count":4},{"id":"GO:0001778","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0048015","count":4},{"id":"GO:0045087","count":3}]},{"hash":"2275033603725371178","title":"Pain and Thermo-Response Signaling","description":"The cluster is dominated by GO terms for sensory pain, temperature stimulus response, and prostaglandin/dopamine signaling, suggesting nociception and thermoregulation with inflammatory modulation. A few terms (e.g., renin secretion, astrocyte chemotaxis) are less directly linked but may relate to CNS inflammatory and signaling contexts, so the label focuses on the core pain- and temperature-related signaling theme.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":19},{"id":"GO:0002024","count":19},{"id":"GO:0071502","count":19},{"id":"GO:0007191","count":18},{"id":"GO:1900135","count":18}]},{"hash":"848668637937269612","title":"Synaptic vesicle trafficking and paranode localization","description":"The top GO terms center on presynaptic vesicle processes (budding, priming) and protein localization to the paranode region of the axon, suggesting a theme of neuronal vesicle dynamics and axon-domain organization. Some development terms (spinal cord, kidney) and regulatory processes appear, but they are less directly tied to the core vesicle/axon functions, likely reflecting broader annotation or multifunctionality. Overall, the cluster seems best described by synaptic vesicle trafficking with axon paranode localization.","confidence":"Medium","size":19,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0016185","count":2},{"id":"GO:0008344","count":2},{"id":"GO:1901998","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0001822","count":2}]},{"hash":"1228899046955375932","title":"Developmental cytoskeleton dynamics","description":"The cluster is dominated by GO terms related to cytoskeletal organization and assembly (mitotic spindle, sarcomere, actin regulation, cell polarity) coupled with developmental processes (bone ossification, skeletal development, lens differentiation, axon guidance). This points to a theme of cytoskeletal remodeling guiding cell differentiation and tissue development, with ribosome biogenesis appearing as a less central housekeeping term. Therefore, a label focusing on cytoskeletal dynamics in development fits best.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":3},{"id":"GO:0071963","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0007411","count":2}]},{"hash":"2152372703133997359","title":"Unknown","description":"The top GO terms are very diverse (apoptosis, endocytosis, lipid catabolism, differentiation, cytoskeletal remodeling, bone remodeling, estrous cycle) with no clear shared pathway or functional theme, and there are no network edges to tie the proteins together; thus there is no coherent cluster function to label.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902512","count":1},{"id":"GO:0031953","count":1},{"id":"GO:0034638","count":1},{"id":"GO:0048714","count":1},{"id":"GO:0006898","count":1}]},{"hash":"443888482963661687","title":"Neural signaling and pain modulation","description":"Based on the top GO terms, the proteins cluster around neuronal GPCR signaling (adenylate cyclase-activating), pain perception and morphine response, and regulation of synaptic transmission, with processes like prepulse inhibition and blood pressure control pointing to autonomic regulation. The inclusion of the electron transport chain aligns with neuronal energy needs, while saliva secretion and thermogenesis suggest autonomic/physiological outputs. Together, these terms imply a cohesive theme of neural signaling with pain modulation and autonomic regulation.","confidence":"Medium","size":19,"edges":11,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":14},{"id":"GO:0022900","count":14},{"id":"GO:0046541","count":14},{"id":"GO:0019233","count":14},{"id":"GO:0060134","count":14}]},{"hash":"850125784992966807","title":"Mechanotransduction and stress-response signaling","description":"The cluster includes terms tied to mechanosensing and adhesion (response to muscle stretch, positive regulation of cell-matrix adhesion, cilium assembly), signaling (positive regulation of GTPase activity), transcriptional regulation, and stress-induced pathways (ER stress\u2013driven apoptosis, defense responses). Together, these point to a cohesive theme of how cells sense mechanical cues and relay signals to regulate growth, division, and stress responses, though the set is diverse.","confidence":"Medium","size":19,"edges":68,"triangles":88,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0061635","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0035994","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0006351","count":2}]},{"hash":"1711537858925034308","title":"Broad developmental and immune signaling","description":"The GO terms show a mix of signaling-related processes (regulation of Rho signaling, NF-kappaB activity, B cell receptor signaling, calcium release regulation) alongside neural and developmental roles (synaptic vesicle priming, glutamatergic transmission, retina layer formation, heart development, mitotic cell cycle). This suggests the proteins function in diverse signaling and developmental contexts across tissues, rather than a single specific pathway, warranting a broad label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0051092","count":4},{"id":"GO:0000278","count":4},{"id":"GO:0016082","count":3},{"id":"GO:0010842","count":3}]},{"hash":"1449933760527752877","title":"Cytoskeletal dynamics and cell adhesion","description":"Top GO terms cluster around actin filament bundle assembly, adhesion/spreading, and junctional polarity (epithelial polarity, tight junction assembly), along with cell migration. While neural and immune signals are present (synapse plasticity, dopamine uptake regulation, B cell signaling), the dominant theme is cytoskeletal remodeling and cell-cell/ECM adhesion processes governing movement and tissue organization.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051017","count":4},{"id":"GO:0051835","count":3},{"id":"GO:0090162","count":3},{"id":"GO:0070830","count":3},{"id":"GO:0016477","count":3}]},{"hash":"1437243214940391916","title":"Diverse metabolite biosynthesis","description":"The top GO terms span multiple biosynthetic pathways across lipids, vitamins/cofactors, steroids, pigments, and even antibiotics, plus an oxidation-reduction process. This pattern points to a functional module of enzymes involved in assembling and modifying a broad set of metabolites rather than a single, narrow pathway.","confidence":"High","size":19,"edges":117,"triangles":317,"max_degree":15,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0055114","count":14},{"id":"GO:0042572","count":9},{"id":"GO:0006704","count":9},{"id":"GO:0046677","count":9},{"id":"GO:0042761","count":9}]},{"hash":"1268635763120078976","title":"Nervous System Development and Sensory Signaling","description":"The top GO terms cluster around nervous system development and sensory processing, including visual perception, long-term synaptic potentiation, Schwann cell development, and inner-ear (labyrinthine) vascular development, plus multicellular organism development. This suggests a coherent theme of neural development and sensory function, with a few terms (amino acid starvation response, prostaglandin signaling, abscisic acid signaling, sperm capacitation) that are less directly related and may reflect noise or broader signaling cross-talk.","confidence":"Medium","size":19,"edges":6,"triangles":1,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060716","count":8},{"id":"GO:0000278","count":8},{"id":"GO:0034198","count":8},{"id":"GO:0007275","count":8},{"id":"GO:0071380","count":7}]},{"hash":"1806785612808378390","title":"Gs-Coupled GPCR Signaling, Thermogenesis, and Inflammation","description":"Predominantly GPCR signaling that activates adenylate cyclase (Gs), with additional terms pointing to energy metabolism, temperature response, blood pressure regulation, and inflammation. The co-occurrence of thermogenesis and inflammatory terms alongside GPCR/AC signaling suggests a functional cluster of Gs-coupled receptor signaling governing metabolic and immune responses.","confidence":"Medium","size":19,"edges":18,"triangles":0,"max_degree":18,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0007190","count":4},{"id":"GO:0010579","count":4},{"id":"GO:0045777","count":4},{"id":"GO:0022900","count":4}]},{"hash":"1705680906392726816","title":"Cardiovascular GPCR Signaling","description":"The cluster is dominated by GO terms for GPCR signaling that activates adenylate cyclase, with dopaminergic signaling and pathways regulating blood pressure and renin secretion, suggesting proteins functionally linked to cardiovascular signal transduction. Related terms like prostaglandin response and astrocyte chemotaxis indicate broader signaling roles but do not override the central GPCR-vascular theme.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":17},{"id":"GO:0022900","count":17},{"id":"GO:0035025","count":17},{"id":"GO:0045777","count":17},{"id":"GO:0007191","count":16}]},{"hash":"129698553921166847","title":"Dopamine Receptor Signaling","description":"The dominant GO terms point to dopaminergic GPCR signaling and downstream pathways (e.g., adenylate cyclase-activating dopamine receptor signaling, dopamine uptake regulation, GPCR-mediated GTPase activity). This suggests the cluster is enriched for proteins involved in dopamine receptor\u2013driven signaling and neuromodulation. Some terms (renin secretion, astrocyte chemotaxis) are broader or indirect, but the core theme is dopaminergic signaling and GPCR-related signaling cascades.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":16},{"id":"GO:1900135","count":16},{"id":"GO:2000458","count":16},{"id":"GO:1901652","count":16},{"id":"GO:0018298","count":16}]},{"hash":"1197891245338271945","title":"Ubiquitin-Proteasome Proteostasis with Circadian Regulation","description":"These terms center on ubiquitin-dependent protein degradation (ubiquitin-dependent protein catabolic process, protein polyubiquitination, SCF-dependent proteasomal ubiquitin-dependent catabolic process), and also highlight circadian rhythm regulation. Additional entries point to neuronal stress and innate immune signaling, including responses to cadmium and methylmercury, synapse assembly in innervation, and oxidative stress-induced neuron apoptosis. Together, the cluster likely represents proteostasis mechanisms modulated by circadian cues in a neuronal/stress-response context.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0042787","count":16},{"id":"GO:0042752","count":11},{"id":"GO:0000209","count":10},{"id":"GO:0031146","count":9},{"id":"GO:0071276","count":9}]},{"hash":"211344944474883145","title":"miRNA regulation and innate immune signaling","description":"Top GO terms cluster around miRNA metabolic processes and miRNA-mediated silencing, alongside innate immune responses such as TNF signaling, chemokine production, and host antiviral defense. While there are some broader or oblique terms (e.g., GTPase regulation, stem cell proliferation), the dominant patterns point to RNA-level gene regulation coupled with immune signaling. Confidence: Medium.","confidence":"","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0007568","count":5},{"id":"GO:0007205","count":5},{"id":"GO:1903265","count":4},{"id":"GO:0035278","count":4}]},{"hash":"362347554368220513","title":"Gene expression and mitosis regulators","description":"The top GO terms point to nuclear processes (DNA-templated transcription, mRNA splicing) and mitotic machinery (mitotic cell cycle, spindle assembly), plus cytoskeletal dynamics (actin depolymerization) and signaling/regulatory activities (Wnt signaling, GTPase regulation). Together these suggest proteins that coordinate gene expression with cell division, i.e., regulators of transcription and mitosis rather than a single isolated function.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":5},{"id":"GO:0043547","count":2},{"id":"GO:0043981","count":2},{"id":"GO:0043982","count":2},{"id":"GO:0043984","count":2}]},{"hash":"422076006485120987","title":"Blood coagulation and inflammatory response","description":"The top GO terms cluster around coagulation and fibrinolysis (blood coagulation, Factor XII activation, regulation of fibrinogen), together with complement activation and responses to lipopolysaccharide, indicating a vascular inflammatory module. A transcription regulation term and a midbrain development term appear but seem non-dominant, so the core signal is coagulation and innate immune activation.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0030901","count":7},{"id":"GO:0007596","count":5},{"id":"GO:0002542","count":5},{"id":"GO:0044537","count":5}]},{"hash":"1990544461514657224","title":"Ubiquitin-Dependent Proteolysis","description":"The top GO terms are dominated by ubiquitination and related protein degradation processes (ubiquitin-dependent catabolic process, autoubiquitination, polyubiquitination, ERAD) with additional links to peroxisomal protein import, NF-kappaB signaling, and receptor turnover (Wnt, V(D)J recombination). This suggests a cohesive theme around the ubiquitin-proteasome system governing protein degradation and regulation, justifying a label centered on ubiquitin-dependent proteolysis.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0030433","count":9},{"id":"GO:0051865","count":8},{"id":"GO:0000209","count":6},{"id":"GO:0016558","count":6}]},{"hash":"2098846871515037896","title":"Neural and vascular developmental signaling","description":"The GO terms cluster around growth factor receptor signaling (HGF/MET, VEGF), receptor tyrosine kinase activation, Hedgehog signaling modulation (Smoothened), neural crest migration, GnRH neuronal migration, hair cell differentiation, and renal artery morphogenesis, indicating a broad but coherent theme of developmental signaling coordinating neural and vascular morphogenesis rather than a single process.","confidence":"High","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048012","count":1},{"id":"GO:0036486","count":1},{"id":"GO:0021828","count":1},{"id":"GO:0048903","count":1},{"id":"GO:0007171","count":1}]},{"hash":"1401303873459291089","title":"Dopamine-Driven Neural and Immune Responses","description":"The top GO terms point to dopamine-related signaling and metabolism (amphetamine response, dopamine catabolism, glutamate receptor regulation) together with neural functions (memory, locomotion) and immune activity (cytokine production, leukocyte migration). This pattern fits a dopamine-driven neural module that may interface with immune responses, justifying the label.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":4},{"id":"GO:0045907","count":4},{"id":"GO:0001816","count":3},{"id":"GO:0042420","count":3},{"id":"GO:1900449","count":3}]},{"hash":"242824284145960177","title":"Neural axon guidance and inflammatory signaling","description":"The top GO terms combine neural development (axonal fasciculation and axon extension in axon guidance) with innate immune signaling (MyD88-dependent TLR pathway, TNF production, LPS signaling) and inflammatory response. This suggests a cluster of proteins involved in both guiding axon growth and modulating immune/inflammatory pathways, possibly reflecting neuro-immune crosstalk. A few terms (like coronary artery morphogenesis) are less related, but the dominant themes point to neural development intertwined with inflammatory signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007413","count":2},{"id":"GO:0048846","count":2},{"id":"GO:0060982","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0032088","count":2}]},{"hash":"1632912810375573747","title":"Epithelial development and ion transport","description":"The cluster centers on skin and nail development and cell-matrix adhesion, which are key to epithelial tissue morphogenesis. Additional terms point to motility and signaling processes (trophoblast migration, synaptic plasticity, heart contraction) and various ion transport activities (calcium, sodium, manganese), suggesting coordinated functions in epithelial maintenance and associated signaling. Overall, a cohesive theme is epithelial development with supporting ion transport/signaling roles.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043588","count":2},{"id":"GO:0007160","count":2},{"id":"GO:0061450","count":1},{"id":"GO:0098703","count":1},{"id":"GO:0048172","count":1}]},{"hash":"875550551574526116","title":"Drosophila Developmental Morphogenesis","description":"The terms cluster around developmental processes in Drosophila, including axonogenesis, dorsal closure, imaginal disc wing hair organization, and eye photoreceptor development, indicating tissue morphogenesis and organ formation. Supporting processes like centrosome cycle and nucleocytoplasmic transport underlie these developmental events, but there isn't a single unified pathway, so the core theme is broad embryonic/imaginal development in the fruit fly.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":2},{"id":"GO:0035508","count":1},{"id":"GO:0007391","count":1},{"id":"GO:0030725","count":1},{"id":"GO:0035690","count":1}]},{"hash":"663596452840233821","title":"Apoptosis and innate immune signaling","description":"The top GO terms cluster around programmed cell death across multiple cell types (cardiac, glial, B cells) and inflammatory/immune signaling (innate immunity, pyroptosis, NOD2 signaling, IL-12 response). This suggests a shared theme of regulated cell death linked to inflammatory responses, with supporting stress signaling such as JNK and TGF-beta pathways, justifying a label centered on apoptosis and innate immune signaling.","confidence":"Medium","size":19,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":1},{"id":"GO:0010659","count":1},{"id":"GO:0071560","count":1},{"id":"GO:0034349","count":1},{"id":"GO:0001783","count":1}]},{"hash":"783531840795829515","title":"ER Proteostasis and Ubiquitin-Proteasome Regulation","description":"The cluster centers on protein quality control and maturation in the secretory pathway: ubiquitin-mediated processes (deubiquitination, ubiquitin-dependent ERAD), regulation of proteasomal degradation, and protein processing such as deglycosylation and insertion of tail-anchored proteins into the ER membrane. This points to a cohesive theme of handling nascent or misfolded proteins and controlling their degradation, with additional signals related to organelle dynamics (mitochondrial fusion) and cellular remodeling (cell morphogenesis and fusion) that may reflect broader network connections. ","confidence":"High","size":18,"edges":75,"triangles":77,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":3},{"id":"GO:0001867","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0006517","count":2},{"id":"GO:0010636","count":2}]},{"hash":"1238264992149903494","title":"Drosophila Development and Morphogenesis","description":"These terms cluster around development and morphogenesis in Drosophila, including oogenesis, dorsal closure, germline ring canal formation, and imaginal disc-derived wing hair organization. Translation and nucleocytoplasmic transport regulation appear as supportive cellular processes in the same context. Overall, the terms suggest a developmental/differentiation program in fly tissues, though the set is somewhat diverse.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043066","count":1},{"id":"GO:0048477","count":1},{"id":"GO:0030154","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0035508","count":1}]},{"hash":"402968661175603365","title":"Innate immunity and apoptosis regulation","description":"This cluster features GO terms for innate immune response, defense against Gram-positive bacteria, and apoptotic processes, with ubiquitination as a common regulatory mechanism. These points suggest a core theme of immune signaling coupled with regulated cell fate and protein turnover. Some terms like mitotic spindle assembly and skeletal system development are broader annotations that may reflect multifunctional proteins or annotation spillover, so the overall signal is moderate. The sparse edges also temper confidence in a tight, cohesive function.","confidence":"Medium","size":18,"edges":2,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0090307","count":4},{"id":"GO:0006915","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0050830","count":4}]},{"hash":"1508408514541981050","title":"DNA repair and genome maintenance","description":"The cluster is dominated by DNA repair-related GO terms (nucleotide excision repair, preincision complex assembly/stabilization, mismatch repair, interstrand cross-link repair, and homologous recombination\u2013mediated repair) and includes DNA replication, pointing to a cohesive theme of genome maintenance and DNA damage response. Some RNA Pol III transcription terms appear ancillary, but do not outweigh the repair signal. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0032728","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0036297","count":1},{"id":"GO:0006294","count":1}]},{"hash":"891798124644859420","title":"Immune activation and tissue remodeling","description":"This cluster centers on immune signaling and inflammatory responses, highlighted by T cell activation via TCR\u2013MHC interactions, complement activation, and blood coagulation. The inclusion of hyaluronan metabolism and negative regulation of extracellular matrix assembly points to extracellular matrix remodeling often linked with inflammation. Together with calcium-responsive signaling, GTPase regulation, ubiquitin-mediated proteolysis, and nuclear import/mRNA transport, the terms suggest a coordinated module of immune activation accompanied by tissue remodeling processes.","confidence":"Medium","size":18,"edges":135,"triangles":598,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0006607","count":5},{"id":"GO:0006511","count":4},{"id":"GO:0051028","count":4},{"id":"GO:0071277","count":4}]},{"hash":"70073062134935920","title":"Organogenesis and Developmental Signaling","description":"This cluster includes GO terms spanning heart and vascular morphogenesis (cardiac right ventricle formation, pulmonary artery morphogenesis), kidney development (distal tubule development), neural guidance (axon extension), and Hedgehog pathway regulation, plus various regulatory processes (muscle growth, coagulation, GnRH response). The wide range of developmental and signaling roles, with no strong single-pathway core and no edges among proteins, suggests a broad developmental/morphogenic function rather than a single unified pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048632","count":2},{"id":"GO:0006508","count":2},{"id":"GO:0061156","count":1},{"id":"GO:0072017","count":1},{"id":"GO:0097211","count":1}]},{"hash":"557140941054674426","title":"Unknown","description":"Unknown","confidence":"","size":18,"edges":141,"triangles":652,"max_degree":17,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":10},{"id":"GO:0000278","count":10},{"id":"GO:0043547","count":10},{"id":"GO:0019236","count":9},{"id":"GO:0051301","count":8}]},{"hash":"1260459837286818375","title":"Ribosome Biogenesis and Translation Initiation","description":"This cluster is dominated by GO terms tied to making ribosomes and starting translation, including ribosome biogenesis, formation of translation preinitiation complex, translation reinitiation, and DNA-templated transcription. While there are some development-related terms present (e.g., multicellular organism development, skeletal system development), the strongest and most coherent signal across the terms is involvement in the protein synthesis machinery, which justifies the label. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0002188","count":4},{"id":"GO:0001731","count":4},{"id":"GO:0051301","count":3},{"id":"GO:0042254","count":3}]},{"hash":"270606719066795207","title":"Osteoclastogenesis and immune regulation","description":"The top GO terms cluster around osteoclast differentiation and bone resorption, plus adaptive immune modulation (T/B cell proliferation, isotype switching, complement activation), suggesting a shared theme of bone remodeling linked to immune signaling. A few terms about receptor internalization and oligodendrocyte progenitor proliferation are general signaling processes that don\u2019t override the main osteoimmune pattern.","confidence":"Medium","size":18,"edges":5,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045780","count":3},{"id":"GO:0030316","count":2},{"id":"GO:0042102","count":2},{"id":"GO:0031623","count":2},{"id":"GO:0030890","count":2}]},{"hash":"1153304737773268245","title":"Neurotransmitter Secretion and Synaptic Signaling","description":"Based on the top GO terms, the cluster centers on regulation and execution of secretion of signaling molecules, especially neurotransmitters (dopamine, GABA) and vesicle priming in neurons, with additional context in endocrine (insulin secretion) and broader signaling (ERK cascade). While there are vascular and platelet-related terms, the strongest signal is neural secretory/synaptic function, suggesting the proteins act in regulated secretion and synaptic signaling.","confidence":"Medium","size":18,"edges":16,"triangles":0,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0014059","count":2},{"id":"GO:0032228","count":2},{"id":"GO:0016525","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0045907","count":2}]},{"hash":"78233699042153422","title":"Growth and Stress Response","description":"This cluster shows simultaneous signals for cell cycle progression (mitotic cell cycle, cell division), various stress/defense responses (defense response to Gram-positive bacteria, cellular response to cadmium ion, response to cocaine), and tissue remodeling/growth processes (collagen catabolic process, angiogenesis regulation, multicellular organism growth). The common thread is broad growth-related and adaptive responses rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0042220","count":3},{"id":"GO:0051301","count":3},{"id":"GO:0071276","count":3},{"id":"GO:0000278","count":3}]},{"hash":"870495755795310353","title":"Neural migration and axon guidance signaling","description":"This cluster is enriched for neural development terms: neural crest cell migration, GnRH neuronal migration to the hypothalamus, facial nerve organization, sympathetic and branchiomotor neuron axon guidance, axon extension and guidance, and related signaling pathways (VEGF, MET/ROCK neuropilin involvement). Together these point to a coherent module coordinating neuron positioning and axon pathfinding, with vascular signaling contributing to guidance cues.","confidence":"High","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0048012","count":3},{"id":"GO:0036486","count":3},{"id":"GO:0021828","count":3},{"id":"GO:0048010","count":3},{"id":"GO:0061441","count":3}]},{"hash":"511923922730860582","title":"MAPK signaling and stimulus responses","description":"Top terms point to core MAPK pathways (ERK1/ERK2 cascade, p38MAPK cascade) and diverse cellular responses to stimuli (phorbol ester, prostaglandin E, GM-CSF, cocaine). The inclusion of growth and invasive growth terms alongside these signaling cascades suggests a coherent role in MAPK-mediated signaling networks that integrate environmental cues to regulate growth, immune signaling, and broader stress responses. This makes a MAPK signaling-focused label plausible and representative.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007124","count":4},{"id":"GO:0042220","count":3},{"id":"GO:0001403","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0043029","count":2}]},{"hash":"1061023138950065435","title":"Sensory and immune GPCR-cGMP signaling","description":"The terms cluster around sensory perception (smell, phototransduction) and immune-related stimulus responses (xenobiotic, LPS, CSF stimuli, neutrophil chemotaxis), with multiple GO terms tied to cGMP signaling and guanylyl cyclase regulation. This points to a shared theme of GPCR/cGMP-mediated signal transduction functioning in both sensory and immune contexts.","confidence":"Medium","size":18,"edges":37,"triangles":25,"max_degree":17,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007608","count":7},{"id":"GO:0035690","count":7},{"id":"GO:0071222","count":7},{"id":"GO:0071321","count":7},{"id":"GO:0010754","count":7}]},{"hash":"318531086746349508","title":"Cytoplasmic Translation Initiation & Ribosome Assembly","description":"The top GO terms cluster around translation initiation in the cytoplasm and ribosome assembly (formation of the preinitiation complex, cytosolic ribosome assembly, translational initiation), with regulatory mentions of initiation and translation inhibition. This suggests the proteins largely participate in the machinery and control of cytoplasmic translation initiation, despite a few outliers in broader developmental terms.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001731","count":2},{"id":"GO:1905537","count":1},{"id":"GO:1905696","count":1},{"id":"GO:1905606","count":1},{"id":"GO:0042256","count":1}]},{"hash":"2201849247948742750","title":"Neuronal development and synaptic signaling","description":"The top GO terms center on nervous system and brain development, regulation of synaptic vesicle exocytosis, and axon-guidance signaling (Roundabout). Rho-mediated signaling and phosphatidylinositol signaling reflect cytoskeletal dynamics and vesicle trafficking critical for neurons, supported by intracellular transport processes. While angiogenesis is present, the dominant theme is neuronal growth, axon guidance, and synaptic regulation.","confidence":"High","size":18,"edges":69,"triangles":51,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:0007399","count":4},{"id":"GO:0031384","count":4},{"id":"GO:0007420","count":4},{"id":"GO:0006886","count":4}]},{"hash":"1380012260674086308","title":"Endosome-Mediated Receptor Trafficking","description":"The top GO terms cluster around endosome organization and the transport between early and late endosomes, plus neurotransmitter receptor transport from endosomes to the postsynaptic membrane, indicating a shared function in vesicular trafficking of receptors. Additional related terms (Rho signaling, death receptor pathways) suggest regulatory links between trafficking dynamics and signaling rather than distinct standalone processes, supporting a cohesive theme of endosome-driven receptor movement.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":2},{"id":"GO:0008625","count":2},{"id":"GO:0042993","count":2},{"id":"GO:0031397","count":2},{"id":"GO:0007032","count":2}]},{"hash":"1266771247670613509","title":"Neuronal synaptic vesicle trafficking and brain development","description":"The terms cluster around neuronal development and synaptic function\u2014excitatory postsynaptic potential, regulation of synaptic vesicle exocytosis, and brain/substantia nigra development\u2014alongside Golgi/ER trafficking between the secretory pathway and plasma membrane; a combined theme of neuronal synaptic vesicle transport and brain development.","confidence":"High","size":18,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060079","count":3},{"id":"GO:0006888","count":3},{"id":"GO:0035690","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0031384","count":3}]},{"hash":"1136257220897849520","title":"Dopaminergic Pain and Sensory Processing","description":"The cluster centers on neural signaling involved in pain perception and sensory processing, with strong representation of dopamine receptor\u2013mediated pathways (adenylate cyclase-activating dopamine signaling), as well as drug responses (morphine, amphetamine) and sensory gating (prepulse inhibition). Temperature-related terms and regulation of glutamatergic transmission suggest broader neuromodulatory context, but the dominant theme is dopaminergic modulation of sensory/pain pathways and drug responses.","confidence":"High","size":18,"edges":8,"triangles":0,"max_degree":4,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":15},{"id":"GO:0002024","count":15},{"id":"GO:0071502","count":15},{"id":"GO:0060134","count":14},{"id":"GO:0043278","count":14}]},{"hash":"1135804736236382583","title":"Neuronal signaling and synaptic vesicle exocytosis","description":"The top GO terms point to neural communication\u2014excitatory postsynaptic potential, brain development, serotonin receptor signaling, and regulation of synaptic vesicle exocytosis\u2014with ion transport in calcium and potassium supporting neurotransmission. A few terms refer to exocytosis in other contexts (acrosome reaction, mating projection growth), but the core pattern is neuronal signaling and vesicle release.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060079","count":2},{"id":"GO:0007340","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0007420","count":2},{"id":"GO:2000300","count":2}]},{"hash":"124556790378668108","title":"Multisystem Developmental Processes","description":"The terms cluster around development across multiple tissues (nervous system, kidney, gonadal lineages, and hematopoietic-related development) with a minor immune signaling term, suggesting a broad, cross-tissue developmental theme rather than a single pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051092","count":2},{"id":"GO:0086091","count":2},{"id":"GO:0035855","count":2},{"id":"GO:0007286","count":2}]},{"hash":"649240585585099055","title":"Dopaminergic signaling and cocaine response","description":"This cluster appears centered on neuronal signaling and sensory modulation, evidenced by dopaminergic synaptic transmission and a behavioral response to cocaine. Additional terms point to vascular and sensory processes (vasoconstriction, prostaglandin response, pain and visual perception) and shared signaling cascades (ERK1/ERK2), suggesting a broader theme of neural signaling with peripheral regulatory connections. The coherence is moderate, with a strong core in dopamine- and drug-related neural activity.","confidence":"Medium","size":18,"edges":81,"triangles":143,"max_degree":14,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":18},{"id":"GO:0043547","count":18},{"id":"GO:0010759","count":18},{"id":"GO:0045907","count":18},{"id":"GO:0001963","count":18}]},{"hash":"900508455958178924","title":"Dopamine GPCR Signaling and Neuromodulation","description":"The top GO terms point to GPCR-driven signaling and modulation in neural and glial contexts, centered on dopamine receptor signaling and dopamine transport, with related prostaglandin responses and GTPase regulation; while some terms reflect broader endocrine signaling, the common theme is neuromodulatory GPCR pathways.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":18},{"id":"GO:1900135","count":18},{"id":"GO:2000458","count":18},{"id":"GO:1901652","count":18},{"id":"GO:0018298","count":18}]},{"hash":"312500676986238589","title":"Neural pain perception and drug response","description":"This cluster is enriched for pain perception, responses to morphine and amphetamine, prepulse inhibition, and glutamatergic neurotransmission, along with GPCR signaling and thermogenesis-related terms. Together these terms point to a neural signaling module governing pain sensation and psychoactive drug responses (with supporting energy metabolism and blood pressure regulation), suggesting a cohesive CNS-focused cluster.","confidence":"High","size":18,"edges":54,"triangles":23,"max_degree":9,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":14},{"id":"GO:0002024","count":14},{"id":"GO:0071502","count":14},{"id":"GO:0010579","count":12},{"id":"GO:0022900","count":12}]},{"hash":"1535047418198936387","title":"Axon guidance and paranodal organization","description":"The top GO terms are dominated by axon extension and guidance (positive regulation of axon extension, axon extension involved in axon guidance, axon guidance) and paranodal/juxoparanodal organization (paranodal junction assembly, protein localization to juxtaparanode region), pointing to a neuronal pathway focused on pathfinding and node maintenance in myelinated fibers. Some vascular development and signaling terms appear, but the core theme centers on axon guidance and paranodal organization.","confidence":"High","size":18,"edges":17,"triangles":0,"max_degree":17,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048842","count":9},{"id":"GO:0030913","count":9},{"id":"GO:0060982","count":9},{"id":"GO:0048846","count":9},{"id":"GO:0071205","count":9}]},{"hash":"266715428999976659","title":"Unknown","description":"The proteins in this cluster show a highly diverse set of GO terms, including lipid digestion and ceramide biosynthesis, developmental processes (hair follicle, metanephric collecting duct), bacterial biosynthesis (O antigen, colanic acid), and plant compound catabolism (lariciresinol, pinoresinol). This lack of a coherent, shared function or pathway across the majority of terms makes it difficult to assign a meaningful, specific label, so Unknown is the appropriate designation.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0072205","count":2},{"id":"GO:0044241","count":2},{"id":"GO:0046513","count":2},{"id":"GO:0006541","count":1}]},{"hash":"1633084278186650218","title":"Cranial nerve development and axon guidance","description":"The top GO terms repeatedly point to cranial nerves (facial nerve structural organization, trigeminal nerve structural organization) and motor neuron axon guidance, including branchiomotor neuron axon guidance and regulation of axon extension. This indicates a cohesive theme of cranial nerve formation and axon pathfinding, with additional neuronal-context signals (IL-6 response, mechanical stimulus) that fit surrounding neuronal development. Some terms like platelet activation or general metabolism are peripheral to the core theme but do not negate it.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:0071354","count":2},{"id":"GO:2001240","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0005975","count":2}]},{"hash":"285194783298000932","title":"Plant secondary metabolism and detoxification","description":"The top terms point to plant-specific metabolite production and breakdown\u2014chlorophyll catabolism, strigolactone biosynthesis, alkaloid metabolism, and defense-related biosynthetic processes\u2014along with redox and lipid-related turnover, yielding a coherent theme of diverse plant metabolism and detoxification.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098869","count":4},{"id":"GO:0015996","count":3},{"id":"GO:0009820","count":3},{"id":"GO:0019433","count":3},{"id":"GO:0046839","count":3}]},{"hash":"1172970058919647045","title":"Plant meristem growth and chromatin regulation","description":"The GO terms cluster around plant development, notably root and vegetative meristem growth and trichome differentiation, and are linked with chromatin organization and chromatin assembly, with hints of hormone regulation (brassinosteroid homeostasis). This suggests a theme of meristem growth control coordinated with epigenetic regulation, despite some noise terms.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060065","count":2},{"id":"GO:0009934","count":1},{"id":"GO:0010449","count":1},{"id":"GO:0010448","count":1},{"id":"GO:0010026","count":1}]},{"hash":"1358067259983185366","title":"Neuronal synapse formation and signaling","description":"The top GO terms center on neural connectivity and signaling: dendritic spine morphogenesis, regulation of excitatory postsynaptic potential, exocytosis, and behaviors such as grooming and social interaction, plus sensory hair cell organization. While a few terms (uterus development, endothelial barrier establishment, centrosome localization) are less obviously related, the dominant pattern points to synapse formation, neurotransmission, and related neural processes.","confidence":"Medium","size":18,"edges":18,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0060997","count":3},{"id":"GO:0060065","count":3},{"id":"GO:0035023","count":2},{"id":"GO:2000821","count":2},{"id":"GO:0060088","count":2}]},{"hash":"1451875813694234334","title":"Dopaminergic Signaling and Vision-Related Behavior","description":"Based on the top GO terms, the cluster is strongly tied to dopaminergic signaling and vision-related processes, including dopaminergic synaptic transmission, dopamine receptor signaling, visual perception/learning, and cocaine-induced behavioral responses. These points suggest a theme of dopamine-driven neural signaling influencing reward and visual/behavioral functions, with other terms (prostaglandin response, macrophage chemotaxis) likely reflecting broader cellular roles. ","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071380","count":18},{"id":"GO:0010759","count":18},{"id":"GO:0001963","count":18},{"id":"GO:0019233","count":18},{"id":"GO:0007601","count":18}]},{"hash":"529499420980469433","title":"Inflammation, Coagulation, and Vascular Regulation","description":"The dominant GO terms describe inflammatory response, lipopolysaccharide response, blood coagulation, and vasoconstriction regulation, with supportive hints of temperature stress and GPCR signaling; the common thread is inflammatory vascular/hemostatic signaling. This makes the label representative of a cluster centered on immune-vascular interactions rather than a single specific pathway.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0045907","count":9},{"id":"GO:0032496","count":9},{"id":"GO:0007596","count":9},{"id":"GO:0006954","count":9}]},{"hash":"700554937860777403","title":"Transcription Regulation and Development","description":"The cluster is dominated by GO terms for transcription regulation by RNA polymerase II (both negative and positive) and developmental processes (midbrain development and post-embryonic development). While other terms like digestion and blood coagulation appear, the strongest shared theme ties gene expression control to developmental stages.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":11},{"id":"GO:0030901","count":6},{"id":"GO:0007586","count":6},{"id":"GO:1902947","count":5},{"id":"GO:0071333","count":5}]},{"hash":"2041738500107011141","title":"N-terminal and polyamine acetylation","description":"The cluster is dominated by acetylation-related GO terms, including multiple N-terminal peptidyl acetylations (glutamic acid, serine, methionine) and spermidine acetylation, indicating a shared function centered on acetylation modifications. Other terms like arginine, melatonin, and ectoine biosynthesis are present but less central, suggesting some noise or broader metabolic associations. Therefore, the label captures the strongest, most coherent theme in the set.","confidence":"Medium","size":18,"edges":150,"triangles":771,"max_degree":17,"top_function":null,"top_go_terms":[{"id":"GO:0006348","count":17},{"id":"GO:0032918","count":16},{"id":"GO:0019491","count":16},{"id":"GO:0018003","count":16},{"id":"GO:0006526","count":16}]},{"hash":"1089385919105910774","title":"Wnt-driven development and synaptic regulation","description":"This cluster centers on developmental signaling and morphogenesis (Wnt signaling, angiogenesis, skeletal development), with a clear emphasis on neural connectivity (neuron projection development and regulation of synaptic plasticity via receptor localization to the synapse) and accompanying endocytic processes (pinocytosis). Together these terms suggest proteins involved in guiding development and establishing/maintaining neural circuits, with receptor trafficking playing a role at synapses. Confidence: High","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0016055","count":3},{"id":"GO:0048549","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0001501","count":3}]},{"hash":"609094451120156439","title":"Phosphoinositide-regulated vesicle trafficking","description":"The terms center on phosphatidylinositol metabolism, endocytic recycling, and synaptic vesicle dynamics, suggesting a cluster of proteins involved in lipid signaling and vesicle trafficking, with a few unrelated annotations likely as noise.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042518","count":2},{"id":"GO:0016310","count":1},{"id":"GO:0019284","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0019509","count":1}]},{"hash":"90858366607002549","title":"Unknown","description":"There is no coherent functional theme among the proteins: the only GO term is GO:0090116 (obsolete C-5 methylation of cytosine) with a count of 1, the network has no edges, and six proteins re-added by ReCIPE show no connections, so no representative function can be inferred.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090116","count":1}]},{"hash":"1115690687537563558","title":"Meiotic Chromosome Cohesion and Spindle Machinery","description":"The top terms strongly point to meiosis-related chromosome dynamics (meiotic sister chromatid cohesion, separation, and spindle elongation) plus nuclear import and protein complex assembly, suggesting a cohesive role in meiotic chromosome segregation and spindle function. A single outlier term on apoptosis signaling is likely noise. ","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051754","count":3},{"id":"GO:0051306","count":3},{"id":"GO:0006607","count":3},{"id":"GO:0006461","count":3},{"id":"GO:1903538","count":3}]},{"hash":"598280606363961733","title":"Inflammation and Complement Signaling","description":"The cluster features multiple GO terms centered on inflammatory response and complement system activity (alternative pathway activation, membrane attack complex activation, regulation of complement). Additional terms like angiogenesis regulation and osteoclast fusion hint at inflammation-related remodeling. These together point to a core theme of immune-inflammation with complement modulation.","confidence":"High","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006954","count":1},{"id":"GO:0010951","count":1},{"id":"GO:0045766","count":1},{"id":"GO:0010884","count":1},{"id":"GO:0010866","count":1}]},{"hash":"463826430135782584","title":"GPCR trafficking and endocytosis","description":"The top terms highlight membrane trafficking processes: GPCR internalization and clathrin-dependent endocytosis, plus protein retention in the Golgi, which together point to receptor trafficking and regulation of signaling rather than a single specific pathway. Some terms such as visual perception or pollen recognition are broader or context-specific, but the core convergence on endocytosis and Golgi retention supports a trafficking-focused label.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048544","count":2},{"id":"GO:0035729","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0045053","count":2},{"id":"GO:0072583","count":2}]},{"hash":"2214665399067821648","title":"Unknown","description":"The top GO terms are split between protein regulation/assembly (ubiquitin-dependent protein catabolic process and protein homooligomerization) and a broad mix of unrelated processes (muscle development, immune signaling, spindle localization, viral latency, gravitropism). The lack of a single cohesive function and no interactions among members suggest there isn\u2019t a clear, interpretable theme for this cluster.","confidence":"","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0051260","count":3},{"id":"GO:0007519","count":2},{"id":"GO:0032764","count":2},{"id":"GO:0035853","count":2}]},{"hash":"394616603159386442","title":"Broad cell signaling and gene regulation","description":"These GO terms reflect regulatory roles across multiple signaling pathways (Wnt, NOD2), differentiation processes (dendritic cell, venous endothelium), RNA processing, transcriptional control, telomere maintenance, and general cell growth. The common thread is modulation of signaling and gene expression across contexts rather than a single pathway, so a broad label is appropriate.","confidence":"Medium","size":18,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001200","count":3},{"id":"GO:1900383","count":3},{"id":"GO:0070431","count":3},{"id":"GO:0000083","count":3},{"id":"GO:0006397","count":3}]},{"hash":"1181797031400053558","title":"Ubiquitin- and autophagy-mediated protein quality control","description":"The proteins show strong representation of post-translational modification and degradation processes, including deubiquitination, sumoylation, and deglycosylation, along with ERAD-related pathways and aggrephagy. These together point to a cohesive role in protein quality control and turnover via ubiquitin-proteasome and autophagic systems, despite a few obsolete terms present.","confidence":"High","size":17,"edges":82,"triangles":248,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0016579","count":6},{"id":"GO:1904378","count":5},{"id":"GO:0006517","count":4},{"id":"GO:1901340","count":4},{"id":"GO:0014070","count":4}]},{"hash":"1862142871749213396","title":"Ubiquitin-Dependent Regulation and ERAD","description":"Based on the top GO terms, the cluster is dominated by ubiquitination-related processes (ubiquitin-dependent ERAD, autoubiquitination, K63- and K11-linked ubiquitination, regulation of ubiquitination), suggesting a shared role in ubiquitin-mediated protein turnover and signaling, with additional connections to cell cycle and chromatin regulation.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0030433","count":17},{"id":"GO:0051865","count":17},{"id":"GO:1902426","count":16},{"id":"GO:0051569","count":16},{"id":"GO:1903955","count":16}]},{"hash":"537079196149282191","title":"Neuronal development and synaptic signaling","description":"The cluster is dominated by neural-related terms: nervous system development, neurogenesis, brain development, and regulation of synaptic vesicle exocytosis, along with ROBO (Roundabout) signaling. These point to a coherent theme of neuronal development and synaptic communication, with a few non-neural annotations likely representing broader signaling roles. ","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"autophagy","top_go_terms":[{"id":"GO:0031384","count":6},{"id":"GO:0035385","count":6},{"id":"GO:0050852","count":6},{"id":"GO:0010796","count":6},{"id":"GO:0007399","count":6}]},{"hash":"736985288356596733","title":"Embryonic organogenesis with immune signaling","description":"This cluster combines developmental terms (mesonephric duct and metanephric limb development, cartilage condensation, lymph vessel morphogenesis) with immune/vascular signaling pathways (C-type lectin receptor signaling, Fc-gamma receptor signaling, cellular response to fungal origin, platelet activation). The shared theme appears to be embryonic organ development accompanied by immune and vascular signaling rather than a single molecular function.","confidence":"Medium","size":17,"edges":87,"triangles":197,"max_degree":16,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0071226","count":16},{"id":"GO:0010572","count":15},{"id":"GO:0001502","count":15},{"id":"GO:0060355","count":14},{"id":"GO:0072177","count":14}]},{"hash":"1667968677143073498","title":"Coagulation, Fibrinolysis, and Cell Adhesion","description":"This cluster is dominated by GO terms for blood coagulation, fibrinolysis, plasminogen activation, and cell adhesion, indicating proteins involved in extracellular matrix remodeling and coagulation pathways. Additional terms about HGF receptor signaling and myoblast differentiation suggest signaling roles during tissue morphogenesis and muscle development, consistent with a remodeling/adherent phenotype.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007155","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0051919","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0055114","count":4}]},{"hash":"1378076405038668202","title":"Embryonic Eye and Neural Development","description":"The top GO terms cluster around eye morphogenesis and lens development (embryonic eye morphogenesis, camera-type eye development, positive regulation of lens epithelial cell proliferation) as well as neural tube patterning and differentiation (floor plate development, somitogenesis, amacrine cell differentiation), indicating a coherent theme of early embryonic organogenesis, particularly eye and neural system development, with related morphogenetic processes.","confidence":"High","size":17,"edges":133,"triangles":636,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0048048","count":9},{"id":"GO:0060441","count":9},{"id":"GO:0043010","count":9},{"id":"GO:0035470","count":8}]},{"hash":"1576082222530572262","title":"RNA processing and mRNA stability regulation","description":"This cluster is dominated by post-transcriptional RNA functions: splicing via the spliceosome, small-subunit processome assembly, mRNA export, and mRNA stabilization/regulation of poly(A) tails, plus ncRNA-mediated gene silencing. The shared theme is RNA maturation and post-transcriptional control, especially under stress. ","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0010610","count":12},{"id":"GO:0031047","count":9},{"id":"GO:0048026","count":9},{"id":"GO:1902625","count":8},{"id":"GO:0034462","count":8}]},{"hash":"1178373292747934628","title":"Dopaminergic Synaptic Signaling and Plasticity","description":"The GO terms cluster around neural signaling and synaptic modulation: dopamine uptake regulation, GPCR signaling, calcium release, and ERK/MAPK cascade, plus a hint of learning functions (visual learning). While a few terms touch on growth or immune responses, the dominant theme is neuronal communication and synaptic plasticity, with dopamine-related regulation as a key driver.","confidence":"High","size":17,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051586","count":4},{"id":"GO:0008283","count":4},{"id":"GO:0070374","count":4},{"id":"GO:0010513","count":4},{"id":"GO:0071260","count":4}]},{"hash":"1847687130127059184","title":"Cardiac neural crest driven heart development","description":"The cluster is dominated by cardiac neural crest\u2013related terms (e.g., cardiac neural crest cell migration involved in outflow tract morphogenesis; cardiac right ventricle formation) and branchiomeric muscle development, pointing to a cohesive theme of cardiac neural crest\u2013driven heart formation. Additional neural differentiation and metabolic-related terms appear ancillary to this core function.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0003253","count":16},{"id":"GO:0014707","count":16},{"id":"GO:0021750","count":16},{"id":"GO:0090128","count":16},{"id":"GO:0061103","count":16}]},{"hash":"1836834244786526620","title":"Embryonic development and organogenesis","description":"The terms show a coherent theme of embryonic patterning and organ formation across multiple tissues (nervous system, pituitary, pancreas, digestive tract, kidneys) plus neural crest migration and primitive streak formation, indicating general developmental regulation and organogenesis rather than a single tissue-specific process. The single transcription regulation term fits into the broader gene-expression control typical of developmental programs.","confidence":"High","size":17,"edges":7,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":10},{"id":"GO:0090190","count":8},{"id":"GO:0048935","count":8},{"id":"GO:0021983","count":8},{"id":"GO:0090009","count":8}]},{"hash":"590588084302301314","title":"Adhesion-driven developmental signaling in nervous and vascular tissues","description":"The cluster centers on cell adhesion and receptor clustering, with terms like heterophilic cell-cell adhesion, receptor clustering, and positive regulation of cell migration in angiogenesis, tying to vascular morphogenesis and organ development (pulmonary artery morphogenesis, distal tubule development). It also includes nervous-system\u2013related terms (gephyrin clustering in postsynaptic density, grooming behavior) suggesting neural development/function. The lithium ion response adds an ion-signaling context common to these processes. Overall, the pattern fits an adhesion- and signaling-driven developmental program spanning nervous and vascular systems.","confidence":"Medium","size":17,"edges":40,"triangles":18,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010226","count":16},{"id":"GO:0007157","count":14},{"id":"GO:0090050","count":14},{"id":"GO:0061156","count":13},{"id":"GO:0097116","count":13}]},{"hash":"371396094000884009","title":"Mitochondrial protein synthesis","description":"The cluster shows strong signals for mitochondrial translation (GO:0032543) and general translation (GO:0006412), suggesting proteins involved in mitochondrial ribosome activity and synthesis of mitochondrial-encoded proteins. A transcription term is much less represented, so the dominant theme is protein synthesis within mitochondria rather than transcriptional regulation or other metabolism. Therefore, the label Mitochondrial protein synthesis best captures the core function of this cluster.","confidence":"High","size":17,"edges":136,"triangles":680,"max_degree":16,"top_function":null,"top_go_terms":[{"id":"GO:0032543","count":3},{"id":"GO:0055114","count":2},{"id":"GO:2000984","count":2},{"id":"GO:0006412","count":2},{"id":"GO:0019295","count":1}]},{"hash":"1146821058190531912","title":"Developmental patterning and epithelial polarity","description":"The terms cluster around developmental processes and tissue organization across diverse systems (insect eye and imaginal disc development, intestinal and follicular epithelium development/polarity, and Notch signaling regulation). While a few terms are from unrelated contexts, the prevailing theme is development and epithelial differentiation. ","confidence":"Medium","size":17,"edges":32,"triangles":5,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0001744","count":2},{"id":"GO:0042248","count":2},{"id":"GO:0002315","count":2},{"id":"GO:0075015","count":2},{"id":"GO:0080147","count":2}]},{"hash":"2023468664537909461","title":"Broad developmental and signaling processes across tissues","description":"The GO terms center on development across multiple tissues (CNS development, glomerular basement membrane development, chondrocyte development, esophagus smooth muscle contraction, innervation) and related signaling regulation (FGFR signaling, GDNF receptor signaling). An outlier term on lipoteichoic acid biosynthesis appears incidental. Overall, the set points to broad developmental and signaling roles across organ systems, supporting a multi-tissue development label.","confidence":"Medium","size":17,"edges":46,"triangles":49,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0007417","count":2},{"id":"GO:0003094","count":2},{"id":"GO:0032836","count":2},{"id":"GO:0014846","count":1},{"id":"GO:0060384","count":1}]},{"hash":"1425491913075078402","title":"Neural Development and Transcription Regulation","description":"The cluster shows strong enrichment for neural development terms (rhombomere 5 development, brain segmentation, spinal cord motor neuron and oligodendrocyte fate specification, subpallium neuron fate) along with general transcription (RNA polymerase II\u2013mediated transcription, DNA-templated transcription). This suggests a coherent module of transcriptional control guiding neural development, with additional associations to broader developmental processes such as endocrine pancreas development and wound healing regulation.","confidence":"High","size":17,"edges":134,"triangles":651,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":12},{"id":"GO:0031018","count":8},{"id":"GO:0021571","count":7},{"id":"GO:0035284","count":7},{"id":"GO:0071353","count":7}]},{"hash":"2191928092778253522","title":"Histone Methylation and Chromatin Silencing","description":"The top GO terms are dominated by histone methylation marks (H3-K4, H3-K27, H3-K9, H4-K20) and by chromatin silencing/heterochromatin formation, pointing to epigenetic regulation of chromatin state. Some development terms appear, but the central theme remains chromatin modification and silencing.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021766","count":3},{"id":"GO:0034773","count":2},{"id":"GO:0080182","count":2},{"id":"GO:0098532","count":2},{"id":"GO:0007507","count":2}]},{"hash":"45717539722571076","title":"Axon Guidance and Neural Development","description":"This cluster is dominated by GO terms related to axon guidance, ROBO signaling, and nervous system development, with supporting links to adherens junction organization and MAPK signaling (ERK/JNK) pathways. These themes point to neuronal pathfinding and tissue organization rather than simple growth, making a neuronal development label most representative. ","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007411","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0035264","count":3},{"id":"GO:0035385","count":3},{"id":"GO:0070374","count":3}]},{"hash":"828439557258943126","title":"Autophagy and organelle turnover","description":"The terms cluster around core autophagy processes: autophagy of mitochondrion, mitophagy, phagophore and autophagosome assembly, Cvt pathway, nucleophagy, and microautophagy of the nucleus, with additional notes on developmental apoptosis. This suggests a cohesive function in autophagic turnover of organelles during development.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035096","count":1},{"id":"GO:0032258","count":1},{"id":"GO:0098779","count":1},{"id":"GO:0000422","count":1},{"id":"GO:0034497","count":1}]},{"hash":"1877623009258938923","title":"Developmental Signaling and Ubiquitin Regulation","description":"These terms point to developmental processes across multiple tissues (spinal cord, brain, retina, skin) and to signaling via JAK-STAT, along with post-translational regulation such as ubiquitination and endocytosis, as well as GTPase regulation and apoptosis. Together, they suggest a cluster of proteins involved in developmental signaling with coordinated protein turnover and regulation.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021510","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007259","count":2},{"id":"GO:0032092","count":2},{"id":"GO:0070086","count":2}]},{"hash":"666913291698996574","title":"Neuronal signaling and vesicle trafficking","description":"The cluster shows enrichment for signaling cascades (ERK/JNK), actin cytoskeleton remodeling, and regulation of synaptic vesicle exocytosis, with brain development supporting a neural context, suggesting these proteins function together in neural signaling and cytoskeletal regulation.","confidence":"Medium","size":17,"edges":5,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031384","count":8},{"id":"GO:0010796","count":8},{"id":"GO:0031532","count":8},{"id":"GO:0033138","count":7},{"id":"GO:0070374","count":7}]},{"hash":"1110784363087959220","title":"T Cell Signaling and Apoptosis","description":"Based on the frequent GO terms, the cluster centers on immune-related signaling and cell death in T cells, including thymus development, T cell homeostasis, interferon signaling, and TNF/apoptotic pathways. Additional terms like phosphatidylinositol-mediated signaling and GTPase regulation reflect intracellular signaling common to immune cells, with a few development- or nonspecific terms that add heterogeneity. Overall, the label captures the dominant theme of T cell\u2013focused signaling and apoptotic responses.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048538","count":2},{"id":"GO:0006907","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0048015","count":2},{"id":"GO:0043029","count":1}]},{"hash":"1373199823154448162","title":"Pain and Temperature Sensory Neuroinflammatory Signaling","description":"The top GO terms cluster around sensory pain perception and temperature response, with supporting signals from dopamine receptor pathways, prostaglandin- and astrocyte-mediated inflammatory responses, and sensitization, suggesting a neuroimmune axis governing nociception and thermoregulation.","confidence":"Medium","size":17,"edges":30,"triangles":7,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":16},{"id":"GO:0002024","count":16},{"id":"GO:0071502","count":16},{"id":"GO:0007191","count":15},{"id":"GO:1900135","count":15}]},{"hash":"2188195298444989183","title":"Axon guidance and neuronal signaling","description":"Based on the enrichment of nervous system\u2013related terms (nervous system development, axon guidance, Roundabout signaling pathway, excitatory postsynaptic potential, ERK cascade), the cluster appears to group proteins involved in neural development and synaptic signaling. Minor terms like ossification and mast cell chemotaxis are present but do not define the core theme; the dominant pattern is neural development and axon guidance.","confidence":"High","size":17,"edges":20,"triangles":1,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":9},{"id":"GO:0007399","count":8},{"id":"GO:0043552","count":7},{"id":"GO:0007411","count":7},{"id":"GO:0070374","count":7}]},{"hash":"29987081821605360","title":"Neural development and axon guidance signaling","description":"The GO terms cluster around neuronal signaling and development: Rho signaling governs cytoskeletal dynamics for growth cones; regulation of synaptic vesicle exocytosis points to synaptic function; Roundabout (ROBO) signaling and axon guidance, ERK cascade activation, and Hedgehog (Smoothened) pathway involvement all align with neural development and pathfinding. Some terms like spermatid development and ossification appear as broader developmental references or annotation spillover, but the core signal is neural development and axon guidance. ","confidence":"Medium","size":17,"edges":92,"triangles":194,"max_degree":13,"top_function":"intracellular protein transport","top_go_terms":[{"id":"GO:0035023","count":5},{"id":"GO:2000300","count":5},{"id":"GO:0043552","count":4},{"id":"GO:0002551","count":4},{"id":"GO:0035385","count":4}]},{"hash":"655344885030811475","title":"Oxidative and immune stress responses","description":"These proteins cluster around cellular stress and immune signaling: responses to hydrogen peroxide and hypoxia, xenobiotic and LPS stimuli, and NF-kappaB-related signaling, with links to extrinsic apoptotic pathways. The mix suggests a shared role in responding to stress with an immune/inflammatory dimension, despite no observed direct protein interactions in the network.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0097192","count":2},{"id":"GO:0042542","count":2},{"id":"GO:0030889","count":2},{"id":"GO:0042493","count":2}]},{"hash":"503776244824093870","title":"Neurovascular and retinal development","description":"This cluster centers on retina morphogenesis, neural growth and guidance (retina layer formation, axonogenesis, facialoacoustic ganglion development, sympathetic neuron projection guidance), and concurrent vascular processes (endothelial cell chemotaxis, angiogenesis, ECM disassembly, and smooth muscle migration), pointing to coordinated neurovascular development and retinal patterning.","confidence":"High","size":17,"edges":1,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0010842","count":14},{"id":"GO:1900242","count":14},{"id":"GO:0060978","count":13},{"id":"GO:0060385","count":13},{"id":"GO:1903375","count":13}]},{"hash":"1724516548556317893","title":"Vertebrate embryonic patterning and organogenesis","description":"The GO terms cluster around developmental patterning and tissue formation, including somitogenesis, floor plate development, left/right pattern formation, and amacrine cell differentiation, along with lung vasculature development and reproductive development (ovulation). Transcription by RNA polymerase II suggests active gene expression driving these programs. The mix points to a theme of vertebrate developmental patterning and organogenesis, with transcriptional regulation underpinning these processes.","confidence":"Medium","size":17,"edges":133,"triangles":638,"max_degree":16,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006366","count":8},{"id":"GO:0001542","count":6},{"id":"GO:0042593","count":6},{"id":"GO:0001756","count":5},{"id":"GO:0033504","count":5}]},{"hash":"1139791013772739132","title":"Proteolytic ECM remodeling and angiogenesis","description":"The terms coalesce around proteolysis and extracellular matrix remodeling (proteolysis, fibrinolysis, plasminogen activation, collagen catabolic process, ECM disassembly) with accompanying positive regulation of angiogenesis, indicating a protein set focused on matrix degradation and blood vessel formation. A few terms related to cell adhesion and complement activation are present but secondary.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0006508","count":6},{"id":"GO:0042730","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0045766","count":4},{"id":"GO:0031639","count":4}]},{"hash":"1149019024217678307","title":"Developmental Morphogenesis Across Tissues","description":"Several top terms point to tissue development (skin, spinal cord, retina, multicellular development) and cell proliferation, indicating a developmental program. Other terms (GTPase regulation, SREBP signaling, protein homooligomerization) suggest associated signaling and protein interaction functions that can modulate development. Together, these proteins appear to participate in developmental morphogenesis across multiple tissues, rather than a single tissue- or pathway-specific process.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0021510","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0051260","count":3}]},{"hash":"1410365805042216294","title":"Signaling Regulation and Tissue Development","description":"The cluster is enriched for GO terms relating to regulation of signaling (GTPase activity, protein phosphorylation) and tissue development (heart, skin), with supporting terms like mRNA transport and apoptotic regulation. Some outliers (ascospore formation, terminal web assembly, hypoxia) exist but do not dominate; overall it reflects signaling control tied to development.","confidence":"Medium","size":17,"edges":15,"triangles":0,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006468","count":2},{"id":"GO:0051028","count":2},{"id":"GO:0031954","count":2},{"id":"GO:1902896","count":2}]},{"hash":"323373534221964191","title":"Wnt-Hippo signaling with apoptosis and keratinocyte differentiation","description":"This cluster is dominated by terms tied to signaling and cell fate decisions: positive regulation of canonical Wnt signaling and Hippo signaling point to growth control and differentiation, while apoptotic processes and keratinocyte differentiation anchor it to cell fate outcomes in epidermal context. Additional terms like potassium ion transport and responses to prostaglandin E and ethanol suggest broader signaling and stress-response roles, with some signals spanning neural-like communication (glutamergic transmission). Overall, the proteins appear to be a cohesive set of regulators of signaling pathways that govern proliferation, differentiation, and survival, especially in epithelial/skin-related contexts, with some auxiliary signaling aspects.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0090263","count":11},{"id":"GO:0035329","count":11},{"id":"GO:0006915","count":11},{"id":"GO:0030216","count":11},{"id":"GO:0060044","count":11}]},{"hash":"1346559258215446968","title":"ECM remodeling and tissue development","description":"This cluster centers on extracellular matrix disassembly and proteolysis (collagen catabolic process, ECM disassembly, proteolysis) alongside developmental processes (midbrain/brain development, endothelial barrier establishment, amelogenesis, multicellular organism growth). Together these terms suggest a common theme of extracellular matrix remodeling driving tissue morphogenesis and neural development, with ECM remodeling linked to barrier formation and organ development. Some terms about transcription regulation and defense responses are present but secondary to the ECM-development signal.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006508","count":4},{"id":"GO:0030901","count":3},{"id":"GO:0030574","count":3},{"id":"GO:1903142","count":3}]},{"hash":"1922946512265388927","title":"Embryonic organ development and innate immune signaling","description":"These proteins show enrichment for developmental processes (mesonephric duct development, metanephric ascending limb development, cartilage condensation, lymph vessel morphogenesis) alongside innate immune signaling pathways (complement activation lectin pathway, C-type lectin receptor signaling, Fc-gamma receptor signaling, response to fungal origin). This suggests dual roles in tissue morphogenesis and immune signaling rather than a single cohesive function, hence a dual-nature label.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":6},{"id":"GO:0001502","count":6},{"id":"GO:0071226","count":5},{"id":"GO:0060355","count":5},{"id":"GO:0072177","count":5}]},{"hash":"2094959700625581393","title":"Heart and skeletal development","description":"The top GO terms cluster around development of heart and skeletal tissues, including heart development, cartilage development, and ossification (intramembranous and endochondral). These consistently point to morphogenesis of cardiac and skeletal structures, with fewer terms related to transcription regulation or detoxification, suggesting the main signal is developmental biology in heart and bones.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0000122","count":3},{"id":"GO:0045944","count":3},{"id":"GO:0007507","count":3},{"id":"GO:0017000","count":2}]},{"hash":"667372240603482529","title":"Bone and vessel morphogenesis","description":"The cluster is enriched for bone formation and osteoblast differentiation, plus coronary artery morphogenesis and Hedgehog pathway regulation, suggesting a developmental program governing skeletal and cardiovascular tissue formation. Some peripheral terms (complement activation lectin pathway, gonadotropin response, ovarian follicle development) are less central to this theme, but the strongest signals point to morphogenesis in bone and vessels.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060346","count":4},{"id":"GO:0045880","count":4},{"id":"GO:2000270","count":3},{"id":"GO:0060982","count":3},{"id":"GO:0001867","count":3}]},{"hash":"994327345789793986","title":"Golgi vesicle trafficking and endomembrane transport","description":"The top GO terms are all centered on vesicle movement through the Golgi and related endomembrane compartments (ER\u2013Golgi transport, Golgi-to-vacuole, endocytosis, retrograde transport, and synaptic vesicle-related budding). This indicates a cohesive role in vesicle trafficking within the Golgi\u2013endosome\u2013ER network, rather than a single isolated process.","confidence":"High","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048313","count":1},{"id":"GO:0006897","count":1},{"id":"GO:0006623","count":1},{"id":"GO:0048490","count":1},{"id":"GO:0006888","count":1}]},{"hash":"1918481121186868379","title":"Growth Hormone Signaling and Development","description":"The top GO terms point to regulation and response processes tied to growth and hormonal signaling, including plant-related growth (root meristem growth; auxin polar transport; cytokinin signaling) and organismal development (response to growth hormone; skeletal muscle and lung development). While several entries are heterogeneous or obsolete, the common thread appears to be growth regulation and developmental signaling across contexts. Overall, this label captures the predominant theme without overfitting to a single pathway.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000299","count":1},{"id":"GO:0071277","count":1},{"id":"GO:0010449","count":1},{"id":"GO:0043947","count":1},{"id":"GO:0048642","count":1}]},{"hash":"7070091747883376","title":"Innate immune defense and cytokine signaling","description":"The top GO terms cluster around innate immunity, including defense against Gram-positive bacteria, response to fungus, Toll-like receptor 9 signaling, and regulation of cytokine production, indicating a cohesive immune signaling theme. Some other terms (e.g., tRNA export, SCF-proteasomal degradation) reflect broader cellular processes or annotation noise, so the core theme is innate immune response. ","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050830","count":3},{"id":"GO:0051770","count":2},{"id":"GO:0050707","count":2},{"id":"GO:0006409","count":2},{"id":"GO:1902745","count":2}]},{"hash":"1532028602014173374","title":"Organelle trafficking and membrane remodeling","description":"The terms cluster around Golgi maintenance (protein retention in Golgi, regulation of Golgi organization) and organelle turnover/dynamics (mitophagy, mitochondrial fusion, peroxisome fission/organization) with trafficking activities (clathrin-dependent endocytosis, membrane tubulation). Collectively, they point to a common function in intracellular membrane trafficking and organelle dynamics across Golgi, mitochondria, and peroxisomes; a few items (interferon response, proliferation regulation) are less central but do not override the core theme.","confidence":"Medium","size":17,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045053","count":2},{"id":"GO:1903358","count":2},{"id":"GO:0010636","count":1},{"id":"GO:0048662","count":1},{"id":"GO:0034340","count":1}]},{"hash":"1501240387079509187","title":"ERAD-Proteostasis Network","description":"Cluster name: ERAD-Proteostasis Network","confidence":"","size":16,"edges":114,"triangles":484,"max_degree":15,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0030433","count":6},{"id":"GO:0034140","count":5},{"id":"GO:1904378","count":5},{"id":"GO:0016579","count":5},{"id":"GO:0070842","count":5}]},{"hash":"1897497132872281522","title":"Cell fusion signaling and fate specification","description":"This cluster prominently features GO terms tied to cell fusion processes and fate specification (e.g., fusion cell fate specification and signaling involved in conjugation with cellular fusion), supported by related signaling regulation (GTPase activity, TGF-beta response) and cytoskeletal localization (actin cortical patch) that together point to a module coordinating fusion events and developmental outcomes. Confidence: Medium","confidence":"","size":16,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0050894","count":9},{"id":"GO:0051044","count":9},{"id":"GO:2000821","count":9},{"id":"GO:0044379","count":9},{"id":"GO:0071560","count":9}]},{"hash":"1409217223185926506","title":"Immune-inflammatory vascular remodeling","description":"The top terms point to immune activation (T cell activation), inflammatory response, and coagulation, coupled with extracellular matrix remodeling (hyaluronan metabolism, cell-matrix adhesion) and endothelial cell behavior. Protein turnover mechanisms (ubiquitin-proteasome) may support rapid signaling and ECM changes during inflammation. Together this suggests immune-driven vascular remodeling and inflammatory/coagulative processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":4},{"id":"GO:0043248","count":3},{"id":"GO:0006511","count":3},{"id":"GO:0030212","count":3},{"id":"GO:0007596","count":3}]},{"hash":"1425144106817983042","title":"RNA processing and translation initiation","description":"This cluster centers on RNA metabolism, including mRNA processing and splicing via the spliceosome, regulation of mRNA stability in stress, small-subunit processome assembly, and translation initiation/reinitiation, indicating a cohesive theme of RNA maturation and initiation of protein synthesis.","confidence":"High","size":16,"edges":105,"triangles":455,"max_degree":14,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":9},{"id":"GO:0002188","count":8},{"id":"GO:0001731","count":8},{"id":"GO:0031047","count":8},{"id":"GO:0010610","count":8}]},{"hash":"50641827470023464","title":"Angiogenesis and adaptive immunity","description":"The top GO terms cluster around blood vessel formation and immune processes, including angiogenesis, adaptive immune response, antigen processing via MHC I, and inflammatory mediators (leukotriene biosynthesis), with supporting signals from renin-angiotensin\u2013related regulation and proteolysis, suggesting a coordinated program linking vascular development with immune signaling.","confidence":"High","size":16,"edges":15,"triangles":0,"max_degree":13,"top_function":"cell differentiation","top_go_terms":[{"id":"GO:0002250","count":6},{"id":"GO:0045766","count":6},{"id":"GO:0001525","count":6},{"id":"GO:0007275","count":6},{"id":"GO:0046718","count":5}]},{"hash":"1721602972714123286","title":"Unknown","description":"This cluster\u2019s GO terms are highly diverse, including redox homeostasis, corneocyte development, DNA recombination, mRNA stability regulation, metabolic regulation, and hormone response, with several obsolete terms. There is no clear shared biological process or function linking the proteins, so a cohesive label isn\u2019t apparent.","confidence":"","size":16,"edges":26,"triangles":3,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:2000466","count":1},{"id":"GO:0080111","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0003335","count":1},{"id":"GO:0045454","count":1}]},{"hash":"1637970412441158179","title":"Unknown","description":"Unknown","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000447","count":2},{"id":"GO:0000472","count":2},{"id":"GO:0000480","count":2},{"id":"GO:0046330","count":2},{"id":"GO:0090557","count":2}]},{"hash":"1102278759389393095","title":"Leukocyte adhesion and signaling","description":"The proteins predominantly map to immune-related processes: regulation of leukocyte chemotaxis, hemopoiesis, B cell differentiation, integrin-mediated signaling, and responses involving PDGF and Kit pathways, all pointing to immune cell development and adhesion signaling to the extracellular matrix.","confidence":"High","size":16,"edges":22,"triangles":7,"max_degree":15,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001954","count":16},{"id":"GO:0002688","count":16},{"id":"GO:0060068","count":16},{"id":"GO:0033138","count":16},{"id":"GO:0030097","count":16}]},{"hash":"1407807478583806629","title":"Mitochondrial protein biogenesis and redox homeostasis","description":"The cluster shows enrichment for mitochondrial-related processes: import of proteins into the mitochondrial matrix, assembly of the respiratory chain (complex II), and redox/copper ion homeostasis, with supporting terms like protein folding and translation, suggesting a cohesive theme around mitochondrial protein biogenesis and maintaining redox balance. Some terms (e.g., oocyte construction, antibiotic biosynthetic process) may be peripheral or annotation noise.","confidence":"Medium","size":16,"edges":120,"triangles":560,"max_degree":15,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0030150","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0016049","count":2},{"id":"GO:0017000","count":2}]},{"hash":"1160097450206432776","title":"Vascular, cardiac, and neural development","description":"The set centers on cardiovascular development (branching of blood vessels, cardiac muscle contraction) and neural signaling (memory, neurotransmitter secretion). While other terms touch on broad developmental processes (cell cycle, apoptosis, ossification, hypoxia, kidney development), the strongest signals connect to heart/blood vessel formation and neural function, suggesting a cohesive theme of cardiovascular and neural development and activity.","confidence":"Medium","size":16,"edges":19,"triangles":5,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":9},{"id":"GO:0072221","count":9},{"id":"GO:0007613","count":8},{"id":"GO:0043065","count":8},{"id":"GO:0071456","count":8}]},{"hash":"2292882182309391819","title":"Retinoid and lipid metabolism","description":"Top terms show a strong tilt toward lipid processing (ether lipids, phospholipids, N-acylphosphatidylethanolamine, lipid transport) and retinoid/vitamin A metabolism (retinol, vitamin A). This suggests the cluster represents proteins involved in lipid and retinoid metabolic pathways, with potential ties to adipose tissue regulation; some outlier terms are present but do not override the core theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":1},{"id":"GO:0006653","count":1},{"id":"GO:0071284","count":1},{"id":"GO:1904177","count":1},{"id":"GO:0006776","count":1}]},{"hash":"1168358098675384887","title":"Viral entry and innate immune response","description":"The terms center on virus-host interactions, including virion attachment and entry into the host cell, viral genome replication, and host defense mechanisms such as cellular and innate immune responses and interferon-beta signaling. Although several GO terms are obsolete and the cluster has no edges, the coherent theme is viral infection processes alongside host antiviral responses, suggesting the proteins may be involved in viral entry/replication and the host defense machinery.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":1},{"id":"GO:0039546","count":1},{"id":"GO:0039707","count":1},{"id":"GO:0039694","count":1},{"id":"GO:0051259","count":1}]},{"hash":"188102367577389611","title":"Neural development and cytoskeletal signaling","description":"This cluster centers on neural development terms such as pyramidal neuron differentiation and axon guidance, and includes Rho-mediated cytoskeletal signaling and ERK cascade regulation, plus cell adhesion. The combination points to coordinated neuronal differentiation and cytoskeletal remodeling essential for neural pathfinding and tissue morphogenesis, with a few developmental terms broadening to general morphogenesis. Confidence: Medium","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":4},{"id":"GO:0021859","count":3},{"id":"GO:0007155","count":3},{"id":"GO:0033564","count":3},{"id":"GO:0045214","count":3}]},{"hash":"527441287294271106","title":"Synaptic endocytosis and actin remodeling","description":"This cluster is enriched for GO terms linking synaptic vesicle endocytosis (GO:1900242), synapse structural plasticity (GO:0051835), and filopodium/actin dynamics (GO:0051489, GO:0046847). It also includes endosome localization (GO:0036010) and JNK signaling (GO:0046330), suggesting a module that coordinates vesicle trafficking with cytoskeletal remodeling to support synaptic plasticity. A peripheral immune term (Th1 response) is present but does not define the core function; overall, the proteins appear to participate in neuronal synaptic trafficking and cytoskeletal regulation.","confidence":"High","size":16,"edges":72,"triangles":122,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":7},{"id":"GO:0031532","count":7},{"id":"GO:0046330","count":7},{"id":"GO:0051489","count":6},{"id":"GO:0046847","count":6}]},{"hash":"1970593723896831986","title":"Neuronal development and synaptic signaling","description":"This cluster is enriched for GO terms related to nervous system and brain development, neuron survival, and regulation of synaptic vesicle exocytosis, pointing to a cohesive theme of neuronal development and synaptic function. Additional terms on PI signaling and GTPase regulation reflect supporting signaling pathways that modulate these neuronal processes.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043524","count":3},{"id":"GO:0007399","count":3},{"id":"GO:0048015","count":3},{"id":"GO:0031384","count":3},{"id":"GO:0007420","count":3}]},{"hash":"2281455425663312592","title":"Neurodevelopmental Signaling and Myelination","description":"The terms cluster around neural development events (neuron migration, myelination, lens fiber differentiation) and associated signaling pathways (ERK cascade, erythropoietin signaling), with additional developmental processes like angiogenesis and branching morphogenesis, suggesting a cohesive theme of neural development and myelination along with related signaling.  ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042552","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0001764","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0060665","count":2}]},{"hash":"1723869977365834678","title":"Neuronal signaling and cytoskeletal dynamics","description":"Dominant GO terms point to GABAergic synaptic transmission and neurotransmitter receptor trafficking, paired with processes of cytoskeletal remodeling (filopodium assembly, GTPase-regulated adhesion and spreading) and cellular trafficking (Golgi localization). This mix supports a theme where neuronal signaling interfaces with cytoskeletal dynamics and membrane trafficking, though one term about fungal cell wall biosynthesis appears as an outlier. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0090051","count":2},{"id":"GO:0090334","count":2},{"id":"GO:1900026","count":2},{"id":"GO:0098887","count":2}]},{"hash":"2252421731773873845","title":"Unknown","description":"The terms span a wide range of tissues and processes (immune signaling, muscle and kidney development) and include cell architecture (adhesion, polarity, cytoskeleton) plus general processes like mitosis and neuronal signaling, yielding no single cohesive function for the cluster. Confidence in a specific, representative label is therefore None.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050853","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0072205","count":2},{"id":"GO:0042994","count":2},{"id":"GO:0090136","count":2}]},{"hash":"1735443178307262475","title":"Embryonic neurovascular development","description":"The terms point to developmental processes across neural and vascular lineages: axonogenesis and neural crest/neuronal migrations, paranodal junctions, ear development, and vascular-related signaling (VEGF and HGF receptors), along with morphogenesis of renal arteries and smooth muscle adhesion. While there is a mix of organ systems, the common theme is embryonic development and morphogenesis of neural and vascular tissues. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060385","count":3},{"id":"GO:0048012","count":2},{"id":"GO:0036486","count":2},{"id":"GO:0021828","count":2},{"id":"GO:0001868","count":2}]},{"hash":"1571481469428027127","title":"GPCR-driven cardiovascular signaling","description":"This cluster is dominated by GO terms for GPCR signaling that activates adenylate cyclase and dopamine receptor pathways, along with prostaglandin responses and regulation of renin secretion and blood pressure. The recurring theme is GPCR-mediated control of cardiovascular and autonomic functions. Other terms such as Rho signaling and astrocyte chemotaxis may reflect broader signaling cross-talk but do not override the central GPCR/blood\u2011pressure pattern.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0035025","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0007191","count":15}]},{"hash":"1887631340568760672","title":"Atrial conduction and action potential regulation","description":"The top GO terms cluster around atrial cardiac muscle electrical activity, including membrane depolarization/repolarization and regulation of atrial cardiac muscle cell action potentials, plus AV node\u2013related depolarization and hypertrophy signaling. There are also broader developmental terms (ossification, vestibular nucleus development) that may reflect pleiotropic roles of the proteins. Overall, the strongest signal is cardiac electrophysiology with atrial-specific regulation.","confidence":"Medium","size":16,"edges":7,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:0007275","count":5},{"id":"GO:1903244","count":4},{"id":"GO:0051260","count":4},{"id":"GO:0098914","count":3}]},{"hash":"1283556970646427841","title":"RNA processing and transcription regulation","description":"This cluster is driven by RNA-biogenesis and gene-expression terms: rRNA maturation (SSU- and 5.8S rRNA), mRNA splicing via spliceosome, and DNA-templated transcription. While other terms (e.g., GTPase regulation, development, cadmium response) are broader and less directly related, the core signals point to roles in RNA processing and transcription control, supporting a coherent theme. Confidence: Medium.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0001501","count":3},{"id":"GO:0006349","count":3},{"id":"GO:0008283","count":3}]},{"hash":"80081119667702329","title":"Growth factor signaling and differentiation","description":"The terms cluster around signaling pathways that govern growth and differentiation: growth hormone receptor signaling, IGF receptor signaling, myoblast differentiation, and skin development, with an additional emphasis on cell survival (negative regulation of apoptosis) and general signal transduction (STAT phosphorylation regulation). While some terms are unrelated (e.g., membrane repair, caffeine response), the dominant theme is growth-factor\u2013driven signaling that influences cell fate and tissue development.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0045445","count":1},{"id":"GO:0060396","count":1},{"id":"GO:0043569","count":1}]},{"hash":"611025941144434453","title":"Pain and Temperature-Driven Immune Signaling","description":"The cluster centers on responses to pain and thermal stimuli (sensory pain, thermogenesis, temperature stimulus) and includes immune/inflammatory processes (defense to bacteria, inflammatory response) with related signaling pathways (GPCR signaling, vasoconstriction). While some terms touch energy metabolism and bone remodeling, the dominant theme is stress-related signaling linking temperature/pain perception with immune and vascular responses.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":7},{"id":"GO:0002024","count":6},{"id":"GO:0071502","count":6},{"id":"GO:0043547","count":5},{"id":"GO:0046849","count":5}]},{"hash":"1758095078755775267","title":"Cardiovascular GPCR Signaling and Renin Regulation","description":"The cluster is dominated by GO terms tied to GPCR-mediated signaling, including adenylate cyclase-activating pathways (e.g., dopamine receptor signaling) and prostaglandin signaling, with strong links to blood pressure regulation via renin secretion. While a few terms (like electron transport chain) are less tied to signaling, the overarching theme points to GPCR-driven cardiovascular and neuroendocrine signaling.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":16},{"id":"GO:0022900","count":16},{"id":"GO:0045777","count":16},{"id":"GO:0007191","count":15},{"id":"GO:1900135","count":15}]},{"hash":"1164380797813014049","title":"Ubiquitin-dependent innate immunity and proteostasis","description":"The GO terms cluster around innate immune response and ubiquitin-driven protein regulation (ERAD, autoubiquitination, K63-linked ubiquitination), including defense against virus, TNF signaling modulation, and aggresome formation, indicating a functional unit coordinating immune signaling with protein quality control.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":5},{"id":"GO:0030433","count":5},{"id":"GO:0051865","count":5},{"id":"GO:0051607","count":4},{"id":"GO:0042787","count":4}]},{"hash":"1841322005725661807","title":"Ubiquitin-Dependent Proteolysis and Circadian Regulation","description":"Based on strong representation of ubiquitin-dependent proteolysis terms (ubiquitin-dependent protein catabolic process, SCF-dependent proteasomal ubiquitin-dependent protein catabolic process, protein autoubiquitination, K6-linked ubiquitination) and the recurring circadian rhythm regulation term, the cluster appears to group proteins involved in targeted protein degradation linked to circadian timing and stress signaling. Additional terms like histone catabolic process support chromatin turnover connections.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0031146","count":8},{"id":"GO:0042752","count":7},{"id":"GO:1903378","count":6},{"id":"GO:0051865","count":6}]},{"hash":"2077278750138518617","title":"Unknown","description":"The top terms are scattered across diverse tissues and processes (muscle differentiation, myeloid apoptosis, cell migration, epithelial polarity, hepatocyte apoptosis, kidney collecting duct development, visual perception, lipid digestion) with no clear shared function or pathway. Because there isn\u2019t a cohesive theme tying these GO terms together, a meaningful, specific label isn\u2019t evident beyond Unknown.","confidence":"","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035914","count":2},{"id":"GO:0033028","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0090162","count":2},{"id":"GO:0097284","count":2}]},{"hash":"625626966509420222","title":"Cell surface receptor signaling and adhesion","description":"This cluster\u2019s terms cluster around processes at the cell surface and in membrane signaling: receptor activation at the plasma membrane, localization to the cell surface, and cell-matrix adhesion, with additional related terms like pattern recognition receptor signaling and modulation of angiogenesis. While there are a few outliers (methylation, iron-sulfur cluster assembly, triglyceride homeostasis), the dominant theme is membrane-associated signaling and adhesion functions. ","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032259","count":1},{"id":"GO:0016226","count":1},{"id":"GO:0051005","count":1},{"id":"GO:0002752","count":1},{"id":"GO:0007160","count":1}]},{"hash":"462957285977531774","title":"Mitochondrial Transport and Membrane Potential","description":"The GO terms cluster around transmembrane transport of metabolites and ions across mitochondria (phosphate, manganese, ATP, citrate, CoA), regulation of mitochondrial membrane potential, and mitochondrial fission/apoptotic changes, indicating a coherent mitochondrial transport and dynamics module.","confidence":"High","size":16,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":16},{"id":"GO:0008637","count":16},{"id":"GO:0006828","count":16},{"id":"GO:1990544","count":16},{"id":"GO:0006843","count":16}]},{"hash":"2208199398234651936","title":"Neuronal Ion Transport and Endocytic Trafficking","description":"The GO terms point to membrane transport and trafficking activities in neurons, including potassium ion transmembrane transport, receptor recycling, endosome size regulation, and glutamatergic synaptic transmission. While a few terms relate to broader signaling processes (phosphatidylinositol dephosphorylation, transcription regulation) and some entries are obsolete, the emerging theme is membrane transport/signaling linked to neuronal receptor cycling and synaptic function. Confidence is moderate due to term diversity and limited interaction evidence.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035023","count":1},{"id":"GO:0051036","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0001881","count":1}]},{"hash":"884021648942978329","title":"Retina development and photoreceptor maintenance","description":"The cluster is strongly linked to vision-related biology: terms for detection of light, photoreceptor outer segment localization, and cilium-associated receptor localization point to retinal photoreceptors and their maintenance. While there are some general developmental terms in the mix (bone development, embryo implantation, hematopoietic differentiation), the visual-system\u2013specific GO terms dominate, suggesting a retinal/ciliary function theme.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060348","count":2},{"id":"GO:0007566","count":2},{"id":"GO:0001955","count":2},{"id":"GO:0002244","count":2},{"id":"GO:0021914","count":1}]},{"hash":"1535613414321194704","title":"Tissue morphogenesis and growth signaling","description":"The top GO terms point to signaling pathways that drive tissue development and remodeling, including branching morphogenesis in glands (salivary and mammary duct growth), hepatocyte growth factor receptor signaling, and myoblast differentiation/proliferation, with some MAPK regulation (p38). While immune-related terms are present, the dominant pattern centers on growth-factor\u2013mediated development and morphogenesis across multiple tissues.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010820","count":2},{"id":"GO:0060665","count":1},{"id":"GO:0048012","count":1},{"id":"GO:0045445","count":1},{"id":"GO:1902947","count":1}]},{"hash":"532167326499885151","title":"Neural Development and Transcription","description":"This cluster is dominated by neural development terms (neural tube closure, forebrain development, brain development), indicating a brain-formation theme. DNA-templated transcription is also prominent, suggesting active transcriptional regulation during development. While a few terms relate to other processes (cell cycle, skeletal development, stress responses), the neural development signal is the strongest, justifying this label.","confidence":"High","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006351","count":3},{"id":"GO:0000278","count":3},{"id":"GO:0001843","count":3},{"id":"GO:0030900","count":3},{"id":"GO:0043547","count":2}]},{"hash":"1078855305747277981","title":"Microtubule-based intracellular transport","description":"The terms point most clearly to transport along microtubules, including intracellular transport of viral material/proteins toward the nucleus and microtubule-based movement, suggesting the cluster is centered on microtubule-dependent transport processes. Other terms (circadian/light signaling, spermatid development, neuron morphogenesis, etc.) appear less directly connected, indicating a broader functional mix but a cohesive transport theme remains dominant.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042753","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0009585","count":1},{"id":"GO:0075521","count":1},{"id":"GO:0007286","count":1}]},{"hash":"147073869323917319","title":"Neural development and synapse formation","description":"The top GO terms indicate neural development and synaptic organization (axonal fasciculation, neural tube formation, dendritic spine maintenance, and synapse assembly), with supporting signals for craniofacial morphogenesis and angiogenesis, which can accompany neural crest\u2013related development. Overall, the cluster centers on neural development and synaptic establishment rather than isolated metabolic processes.","confidence":"Medium","size":16,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048701","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0006397","count":1}]},{"hash":"1149761916745998345","title":"Immune signaling and stress response","description":"The cluster centers on immune-related signaling and processing: non-canonical NF-kappaB signaling, antigen processing and MHC class I presentation, and activation of the membrane attack complex, all pointing to immune function. It also includes elements of cellular stress and proteostasis, such as cadmium ion response and SCF-dependent ubiquitin-proteasome\u2013mediated proteolysis, plus regulation of nitric oxide signaling, which are common in stress- and immune-response contexts. Some terms touch on development and plant immune responses, suggesting a broad, cross-kingdom theme of immune/stress signaling. Overall, the dominant pattern is immune signaling and stress response.","confidence":"Medium","size":15,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0046686","count":2},{"id":"GO:0001558","count":2},{"id":"GO:0010751","count":2},{"id":"GO:0030324","count":2},{"id":"GO:0001970","count":2}]},{"hash":"1513507016582969049","title":"RNA processing and translation regulation during cell cycle","description":"This cluster centers on RNA processing and translation control, with GO terms for mRNA export, splicing regulation, regulatory ncRNA-mediated silencing, and translation initiation/reinitiation, plus formation of preinitiation complexes. It also includes keywords related to the mitotic cell cycle and microtubule-based movement, suggesting coordination of gene expression machinery with cell cycle progression. A few terms (e.g., SREBP signaling, ubiquitin ligase regulation) may reflect broader regulatory links, but the core theme appears to be RNA processing and translation control in the context of cell division.","confidence":"Medium","size":15,"edges":80,"triangles":267,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0006406","count":2},{"id":"GO:0031047","count":2},{"id":"GO:0032933","count":2},{"id":"GO:0048026","count":2}]},{"hash":"1633167366150271029","title":"Immune and Angiogenic Signaling","description":"Most terms point to immune defense and leukocyte movement (defense response to Gram-positive bacteria; regulation of leukocyte chemotaxis), together with tissue remodeling and signaling leading to angiogenesis (positive regulation of angiogenesis; positive regulation of cell-matrix adhesion; MAPK cascade). Prostaglandin and glucose stimulus responses indicate metabolic/inflammatory signaling, reinforcing a theme of coordinated immune and vascular remodeling during inflammation. A few terms (vagina development; Sho1 osmosensor) are peripheral, but the dominant pattern supports immune- and angiogenesis-related signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071333","count":14},{"id":"GO:0045766","count":14},{"id":"GO:0050830","count":14},{"id":"GO:0014068","count":14},{"id":"GO:0001954","count":13}]},{"hash":"503095103533898852","title":"Ribosome Biogenesis and Translational Fidelity","description":"Defined by translation and ribosome biogenesis terms (ribosomal subunit assembly, rRNA maturation) and regulation/maintenance of translational fidelity, indicating a cluster of proteins involved in assembling functional ribosomes and ensuring accurate translation; the antibiotic response term is a minor related note.","confidence":"High","size":15,"edges":93,"triangles":324,"max_degree":14,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0042254","count":3},{"id":"GO:0042273","count":3},{"id":"GO:0000027","count":2},{"id":"GO:0006450","count":1}]},{"hash":"690431091154363418","title":"Neurodevelopment and brain region specification","description":"This cluster centers on neural development and regional specification, with enriched terms for brain-related differentiation (olfactory bulb interneurons, locus ceruleus, spinal cord, pituitary) and ectoderm formation, plus neuromuscular processes and neuron survival regulation indicating a neurodevelopmental theme.","confidence":"High","size":15,"edges":13,"triangles":2,"max_degree":6,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0043524","count":9},{"id":"GO:0007275","count":9},{"id":"GO:0021983","count":9},{"id":"GO:0042663","count":8},{"id":"GO:0021889","count":8}]},{"hash":"586519675262564398","title":"Protein quality control and trafficking","description":"The top terms cluster around cellular protein handling and movement: ubiquitin-dependent ERAD and ER-to-Golgi transport point to quality control and degradation pathways, while autophagy of peroxisomes adds to catabolic processing. Microtubule severing and CENP-A\u2013related chromatin assembly hook into cytoskeletal organization and cell division, and protein homooligomerization plus transport fit into assembly/trafficking processes. While \u201cbrain development\u201d appears, the overall theme centers on protein homeostasis and intracellular trafficking with links to mitosis, making a cohesive but broad protein-homeostasis/trafficking cluster.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0051013","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0006888","count":2}]},{"hash":"1457665343412218902","title":"Steroid signaling and innate immunity.","description":"This cluster combines GO terms tied to hormone signaling and reproductive development (steroid hormone receptor complex assembly; prostate gland development; male sex differentiation; negative regulation of GA signaling; GPCR signaling regulation) with innate immune and antiviral responses (innate immune response; cellular response to type I interferon; cellular response to dsRNA; defense against virus). The mixed terms suggest a signaling-focused group spanning endocrine signaling and antiviral defense, but without observed edges connecting the proteins, the label reflects a broad signaling role rather than a tightly cohesive, single-function module.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0009938","count":6},{"id":"GO:0006463","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0030850","count":6}]},{"hash":"1214410568341025040","title":"Neuronal mitochondrial function and signaling","description":"The cluster centers on mitochondria-related processes (calcium import into mitochondrion; protein import into mitochondrial matrix; negative regulation of ROS) together with neural activity terms (neuron-neuron synaptic transmission; learning; behavioral fear response). This suggests mitochondria support neural signaling and plasticity, with auxiliary terms like cilium assembly regulation and ion transport fitting into broad neuronal signaling contexts. Overall, the functions point to a theme of mitochondrial maintenance contributing to neuronal communication and learning.","confidence":"High","size":15,"edges":22,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:2000378","count":2},{"id":"GO:0036444","count":2},{"id":"GO:0030150","count":2},{"id":"GO:0007612","count":2},{"id":"GO:1903959","count":2}]},{"hash":"1493675631829623917","title":"Embryonic development and tissue morphogenesis","description":"GO terms span placental and endocrine development, EMT in heart cushion formation, left-right patterning, cartilage morphogenesis, hyaluronan metabolism, and ECM regulation, pointing to a theme of embryonic tissue morphogenesis and matrix remodeling rather than a single specific pathway.","confidence":"Medium","size":15,"edges":21,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003323","count":1},{"id":"GO:0060972","count":1}]},{"hash":"1802863833788356819","title":"Cerebellar development and immune signaling","description":"This cluster centers on cerebellar neural development (cerebellar cortex formation, Bergmann glial differentiation, axon regeneration) but also includes several immune and signaling pathways (insulin receptor signaling, T cell receptor signaling, NK cell cytotoxicity, TLR3 signaling, ERK cascade regulation), suggesting a module that links cerebellar development with CNS immune signaling and signaling regulation.","confidence":"Medium","size":15,"edges":79,"triangles":220,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0021697","count":11},{"id":"GO:0060020","count":11},{"id":"GO:0008286","count":11},{"id":"GO:0050852","count":11},{"id":"GO:2001275","count":11}]},{"hash":"107580941648364814","title":"Translation and ribosome assembly","description":"Most top GO terms are about translation and ribosome assembly (ribosomal large subunit assembly, cytoplasmic translation, translation). A few terms point to apoptosis, lens differentiation, TGF-beta signaling, growth hormone response, and mitochondria-nucleus signaling, but the dominant signal is protein synthesis machinery. ","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000027","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0010659","count":1},{"id":"GO:0070306","count":1}]},{"hash":"714400437054930890","title":"Neuronal actin remodeling and synaptic plasticity","description":"The cluster is driven by actin cytoskeleton and Rho signaling terms (regulation of Rho protein signal transduction, actin cortical patch localization, microspike assembly, cell polarity), combined with synaptic plasticity terms (long-term depression and potentiation) and cell adhesion, all pointing to neuronal cytoskeletal remodeling governing synaptic structure and plasticity, with some behavioral implications. ","confidence":"High","size":15,"edges":12,"triangles":0,"max_degree":12,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0035023","count":6},{"id":"GO:0051666","count":6},{"id":"GO:1900042","count":6},{"id":"GO:0045737","count":6},{"id":"GO:0071963","count":6}]},{"hash":"1969439519415051457","title":"Ubiquitin-dependent proteolysis and NF-\u03baB signaling","description":"The cluster is dominated by ubiquitination-related terms (ubiquitin-dependent proteolysis, ERAD, autoubiquitination, K63-linked ubiquitination) and NF-\u03baB pathway components (I\u03baB phosphorylation, NF-\u03baB activation, NIK), suggesting a cohesive theme of protein turnover linked to inflammatory signaling.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0046232","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0070535","count":3}]},{"hash":"1557509035891538394","title":"RNAi processing and gene silencing","description":"The GO terms are dominated by RNA interference-related processes\u2014RNAi-mediated antiviral response, siRNA processing, and co-transcriptional gene silencing by RNA interference machinery\u2014suggesting the proteins primarily function in RNAi pathways. A few unrelated terms appear but with low representation, so the core theme is RNAi processing and silencing.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009616","count":1},{"id":"GO:0010495","count":1},{"id":"GO:0030422","count":1},{"id":"GO:0070919","count":1},{"id":"GO:0033562","count":1}]},{"hash":"1689331723386021283","title":"Neural development and axon guidance signaling","description":"The cluster is dominated by nervous system development terms (nervous system development, retina morphogenesis, synapse organization) and axon-related signaling (Roundabout signaling/ROBO, Smoothened signaling) with protein localization to axon regions, pointing to a neural development/axon guidance module. A few terms (T cell receptor signaling, kidney/vagina development) are present but less representative of the main theme.","confidence":"High","size":15,"edges":97,"triangles":366,"max_degree":14,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0035385","count":9},{"id":"GO:0050852","count":9},{"id":"GO:0007399","count":9},{"id":"GO:0007224","count":8},{"id":"GO:0001822","count":8}]},{"hash":"1104915830968822030","title":"Inflammation-Platelet GPCR Signaling","description":"The top GO terms cluster around inflammatory response and platelet activation, with GPCR-linked signaling (dopamine receptor signaling; prostaglandin response) and regulatory processes like GTPase activity and renin secretion, suggesting a coherent inflammatory-vascular signaling module with neuroimmune components.","confidence":"Medium","size":15,"edges":3,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0006954","count":13},{"id":"GO:0030168","count":12},{"id":"GO:0007191","count":11},{"id":"GO:1900135","count":11},{"id":"GO:2000458","count":11}]},{"hash":"660935767612615624","title":"Pain and Temperature Sensory Signaling","description":"This cluster is dominated by GO terms related to pain perception and temperature-related sensing (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis, prostaglandin signaling). The inclusion of dopamine receptor signaling and sensitization points to neurochemical modulation of these sensory pathways, with some annotations on astrocyte activity and endocrine regulation, suggesting a broader neuroimmune\u2013metabolic signaling theme centered on pain and temperature responses.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":11},{"id":"GO:0002024","count":11},{"id":"GO:0071502","count":11},{"id":"GO:0007191","count":10},{"id":"GO:1900135","count":10}]},{"hash":"1486062458695248293","title":"Neurovascular development and organ morphogenesis","description":"These proteins cluster around growth factor receptor signaling (HGF, VEGF), neural crest and neuronal migration/axon guidance, paranodal junctions, and organ morphogenesis (renal artery development, ear development). Together they imply coordinated signaling driving neural and vascular development and organ formation, with a possible minor outlier from complement regulation.","confidence":"High","size":15,"edges":36,"triangles":36,"max_degree":13,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048012","count":14},{"id":"GO:0036486","count":14},{"id":"GO:0021828","count":14},{"id":"GO:0001868","count":14},{"id":"GO:0030913","count":14}]},{"hash":"2044072084985583157","title":"Neuronal migration and synapse formation","description":"The cluster is dominated by GO terms related to neural development, including synapse assembly and maturation, neuronal migration, and cell adhesion (e.g., positive regulation of synapse assembly/maturation, tangential migration to the olfactory bulb, heterophilic cell-cell adhesion, planar polarity). These themes point to coordinated processes underlying neurodevelopment and synaptogenesis, with a few miscellaneous terms like heparin response that do not alter the overall interpretation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051965","count":12},{"id":"GO:0071504","count":11},{"id":"GO:0090260","count":11},{"id":"GO:0022028","count":11},{"id":"GO:0090251","count":11}]},{"hash":"1251630510113573827","title":"Innate Immunity and Mitosis","description":"This cluster combines strong signals of innate immune response and inflammatory processes (innate immunity, pyroptosis, apoptosis, ubiquitination, integrin signaling) with mitotic-related terms (mitotic spindle assembly, cell division). The co-occurrence suggests a cross-talk between immune signaling and cell-cycle regulatory mechanisms, hence a label that captures both themes is appropriate.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":8},{"id":"GO:0090307","count":8},{"id":"GO:0051301","count":7},{"id":"GO:0070208","count":6},{"id":"GO:0000278","count":6}]},{"hash":"109734196047288941","title":"Calcium-mediated muscle and vascular development","description":"The cluster\u2019s top GO terms point to calcium handling (calcium ion import across the plasma membrane) together with muscle and vascular processes (skeletal muscle regeneration, endothelial cell delamination, Notch signaling in heart development). The co-occurrence of calcium-related signaling with muscle and vascular remodeling, plus related pathways such as GPCR/PKC signaling and vitamin D responses, suggests a shared theme of calcium-dependent regulation coordinating muscle growth and vascular development. Therefore this label captures the dominant thread across the terms.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":6},{"id":"GO:0070213","count":5},{"id":"GO:0097497","count":5},{"id":"GO:0007205","count":5},{"id":"GO:1903759","count":5}]},{"hash":"444984831455830575","title":"Unknown","description":"The top GO terms span NF-\u03baB regulation, cardiac action potential, viral mRNA export, GTPase phosphorylation, social behavior, microtubule movement, mechanical response, LPS signaling, endothelial barrier establishment, and peptidyl-tyrosine phosphorylation\u2014too diverse to tie to a single function. No clear functional linkage is evident and the graph has no edges, so a coherent label cannot be assigned.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0032088","count":5},{"id":"GO:0098907","count":4},{"id":"GO:0046784","count":4},{"id":"GO:0043547","count":3},{"id":"GO:0035176","count":3}]},{"hash":"496345181634323387","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around nervous system development and synaptic function: axonogenesis, Schwann cell development, excitatory postsynaptic potential, and visual perception, suggesting roles in neural formation and neuronal communication. Some terms (innate immune response, heart development, ABA signaling) are broader or pleiotropic annotations that may reflect multi-function proteins, but the predominant neural-development and synaptic terms support this thematic label.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":9},{"id":"GO:0007409","count":9},{"id":"GO:0000086","count":8},{"id":"GO:0014044","count":8},{"id":"GO:0060079","count":8}]},{"hash":"2161505324929590820","title":"ECM Remodeling and Cell Migration","description":"This cluster is dominated by extracellular matrix interactions and cell adhesion terms (integrin signaling, collagen fibril organization, calcium-independent cell-matrix adhesion) along with multiple migration and morphogenesis signals (keratinocyte/fibroblast migration, face morphogenesis, BMP/VEGF pathways). The convergence on ECM remodeling, adhesion, and tissue morphogenesis explains the inclusion of angiogenesis and ovulation-related processes as context of ECM-driven remodeling. Overall, the proteins appear to coordinate ECM remodeling with cell movement during development and tissue structuring.","confidence":"High","size":15,"edges":14,"triangles":0,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0071773","count":2},{"id":"GO:0051549","count":2},{"id":"GO:0001542","count":2}]},{"hash":"135460107447698331","title":"Mitotic Regulation and Chromosome Segregation","description":"The top GO terms are dominated by cell cycle and mitosis-related processes, including general cell cycle (GO:0007049), exit from mitosis, and chromosome passenger complex localization to spindle midzone, suggesting a cohesive theme of mitotic progression and chromosome segregation. Some terms also touch synaptic organization and signaling regulation, but the strongest signal centers on mitotic control and spindle dynamics, so the label reflects the core function of this cluster.","confidence":"High","size":15,"edges":104,"triangles":442,"max_degree":14,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":11},{"id":"GO:0051895","count":11},{"id":"GO:0097107","count":11},{"id":"GO:1903984","count":11},{"id":"GO:2000808","count":11}]},{"hash":"2103545836083282751","title":"Innate immune signaling and antiviral defense","description":"The cluster is driven by terms related to innate immunity and antiviral defense, including innate immune response, defense against viruses, and the TLR9 signaling pathway with modulation of NF-kappaB activity. These connections suggest a coherent theme of host defense and inflammatory signaling, despite a few outlier annotations (e.g., visual perception, development). Overall, the label captures the central function of the set.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0051607","count":2},{"id":"GO:0043124","count":2},{"id":"GO:0007601","count":2},{"id":"GO:0072205","count":2}]},{"hash":"257054502814728190","title":"Proteostasis and RNA processing","description":"This cluster centers on protein turnover and energy use (proteasome assembly, protein catabolic processes, ATP metabolism) together with RNA-centric processes (mRNA export, transcription elongation), plus vesicle trafficking and autophagic degradation, suggesting a theme of cellular homeostasis through coordinated protein turnover and gene expression regulation. Some terms appear unrelated (e.g., blastocyst development, competence for transformation), likely reflecting annotation noise rather than a core function.","confidence":"Medium","size":15,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0051301","count":6},{"id":"GO:0070682","count":6},{"id":"GO:0070676","count":5},{"id":"GO:0030420","count":5},{"id":"GO:0046034","count":5}]},{"hash":"178749846335685701","title":"Neuronal adhesion and synapse development","description":"The cluster is dominated by GO terms for cell-matrix adhesion, axon fasciculation in sensory neurons, and positive regulation of synapse assembly, plus multicellular development and cell-cell adhesion, all pointing to neuronal connectivity and synaptogenesis. While there are a few immune-related terms in the mix (e.g., muramyl dipeptide response, lectin pathway), the strongest signals pertain to neuronal adhesion and synapse formation. ","confidence":"High","size":15,"edges":17,"triangles":2,"max_degree":6,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007160","count":11},{"id":"GO:0097155","count":10},{"id":"GO:0051965","count":10},{"id":"GO:0032495","count":9},{"id":"GO:0071372","count":9}]},{"hash":"636458550439572479","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning oxidation-reduction, antibiotic biosynthesis, platelet activation, cellulose breakdown, vision, immune response, insulin secretion, fear behavior, cell proliferation regulation, and cytolysis. With no edges or clear functional connectivity, there isn\u2019t a cohesive theme to label the cluster with a concise, representative name.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0017000","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0030245","count":2},{"id":"GO:0007601","count":2}]},{"hash":"1247161235960825218","title":"Developmental migration and RTK signaling","description":"Top GO terms cluster around developmental cell movement (neural crest, various neuronal migrations, hair cell differentiation) and signaling pathways driven by receptor tyrosine kinases (e.g., MET/HGF, VEGF receptors). Together these indicate proteins involved in migratory and morphogenetic processes during development and vascular/neuronal differentiation. The molting cycle term appears as an outlier artifact rather than part of the core theme.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0018996","count":5},{"id":"GO:0002042","count":4},{"id":"GO:0010745","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0036486","count":3}]},{"hash":"1214644737812753463","title":"Ubiquitin-Dependent Regulation of Signaling and Chromatin","description":"These proteins are collectively annotated with ubiquitin-related processes: ubiquitin-dependent proteolysis, autoubiquitination, various ubiquitin linkages (including K6- and K63-linked), and connections to key signaling pathways such as TNF and NF-kappaB, as well as I-kappaB phosphorylation. The inclusion of histone catabolic processes and V(D)J recombination ties the cluster to chromatin dynamics and immune system rearrangement regulated by ubiquitination. The circadian rhythm term further suggests time-regulated control via the ubiquitin system. Together, these points support a cohesive theme of ubiquitin-mediated regulation of signaling and chromatin functions.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":13},{"id":"GO:0042752","count":7},{"id":"GO:0051865","count":6},{"id":"GO:0036205","count":6},{"id":"GO:1903265","count":6}]},{"hash":"29741234338139171","title":"Neuronal adhesion and synapse assembly","description":"The cluster is enriched for cell-cell adhesion terms (heterophilic and homophilic) and synapse assembly processes, including gephyrin clustering at postsynaptic density, plus dopaminergic axon guidance and behaviors linked to neural circuits. Plasminogen activation hints at extracellular remodeling aiding synapse formation. While some terms touch on broader physiological processes (cortisol response, development), the dominant theme is neuronal adhesion and synaptic organization, especially in dopaminergic/gabaergic synapses.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007157","count":10},{"id":"GO:0007156","count":9},{"id":"GO:0051965","count":9},{"id":"GO:0031639","count":9},{"id":"GO:0097116","count":8}]},{"hash":"1968538755294672001","title":"Unknown","description":"The Top Terms span a wide range of biosynthetic and metabolic processes across different organisms (bacterial O antigen and colanic acid biosynthesis, sporopollenin biosynthesis, polyhydroxybutyrate biosynthesis), along with lignan catabolism, L-glutamine metabolism, and DNA-templated transcription. With no clear single functional thread or strong interconnection among these terms (and no edges linking the proteins), there isn\u2019t a coherent cluster function to name beyond unknown.","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:0006541","count":1},{"id":"GO:1902131","count":1},{"id":"GO:0009243","count":1},{"id":"GO:0042619","count":1}]},{"hash":"1539773129983376406","title":"Ubiquitin-Mediated Innate Immunity","description":"The top GO terms point to ubiquitin-dependent proteolysis and broad innate immune activity, including defense against virus and NF-kappaB/TNF signaling involvement via K63-linked ubiquitination, suggesting a cluster of proteins coordinating ubiquitin-regulated antiviral and immune signaling pathways.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0045087","count":7},{"id":"GO:0051607","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0051092","count":5}]},{"hash":"651379379338289651","title":"Ubiquitin-Dependent Protein Degradation","description":"The top terms are dominated by ubiquitination and ubiquitin-dependent protein catabolic processes, pointing to a proteostasis-focused cluster. Some entries also touch on receptor turnover and growth regulation, suggesting broader links to protein turnover and cellular growth, but the central theme remains ubiquitin-mediated protein degradation.","confidence":"High","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0016567","count":5},{"id":"GO:0038018","count":4},{"id":"GO:1900095","count":4},{"id":"GO:0030433","count":4}]},{"hash":"851483350125860708","title":"Unknown","description":"Unknown","confidence":"","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042254","count":2},{"id":"GO:1904751","count":1},{"id":"GO:0032211","count":1},{"id":"GO:0051096","count":1},{"id":"GO:0000494","count":1}]},{"hash":"1562289952761026852","title":"Morphogenesis and Growth Factor Signaling","description":"The top terms cluster around developmental signaling and tissue morphogenesis\u2014e.g., salivary gland branching morphogenesis, HGF receptor signaling, myoblast differentiation/proliferation, and mammary duct growth\u2014suggesting a shared theme of growth-factor\u2013driven morphogenesis. Some terms also touch on coagulation, fibrinolysis, and immune signaling, indicating broader roles, but the core signal remains developmental growth and morphogenesis. ","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":1},{"id":"GO:0048012","count":1},{"id":"GO:0045445","count":1},{"id":"GO:1902947","count":1},{"id":"GO:0007596","count":1}]},{"hash":"1743066631076784706","title":"Neural cytoskeleton and microtubule transport","description":"The cluster shows a pattern of microtubule-based movement and intracellular transport (GO:0007018, GO:0019060) along with cytoskeleton regulation (GO:0051493) and neuron-related development terms (GO:0048812, GO:0007399), as well as sensory perception of sound (GO:0007605), suggesting a focus on neural development and axonal transport rather than a broader non-neural theme. Some terms like spermatid development appear less connected, but the dominant signal points to neural cytoskeleton dynamics.","confidence":"Medium","size":15,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007605","count":2},{"id":"GO:0075521","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0008340","count":1},{"id":"GO:0019060","count":1}]},{"hash":"817499013565789634","title":"ER protein quality control and membrane trafficking","description":"Most top GO terms point to ER-associated processes: ubiquitin-dependent ERAD pathway, protein deglycosylation, and tail-anchored insertion into the ER membrane, along with regulation of proteasomal degradation and ER-related calcium signaling. Although a few terms touch on mitochondria, cell division, or neural development, the core theme is ER-based protein processing and quality control, which justifies the label.","confidence":"Medium","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0006517","count":4},{"id":"GO:0010636","count":4},{"id":"GO:1901799","count":4},{"id":"GO:0071816","count":4}]},{"hash":"1696546031541456405","title":"Nematode Molting and Pharyngeal Function","description":"The GO terms point to nematode-specific development and feeding processes: molting/cuticle formation, head morphogenesis, and pharyngeal pumping. Together these suggest a cluster of proteins involved in nematode development and feeding mechanics, linking cuticle biology with pharyngeal function.","confidence":"Medium","size":14,"edges":20,"triangles":17,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0060325","count":1},{"id":"GO:0018996","count":1},{"id":"GO:0043050","count":1}]},{"hash":"960446173453243144","title":"Oxidative stress response and detoxification","description":"The GO terms show a pattern of responding to oxidative and nitrosative stress (and LPS) supplemented by detoxification-related metabolism (lipid/aldehyde metabolism, retinol metabolism, PPP-related biosynthesis), suggesting a cohesive theme of managing cellular stress and clearing reactive compounds, even if some terms are context-specific. This points to a functional cluster focused on stress defense and detox pathways.","confidence":"Medium","size":14,"edges":21,"triangles":14,"max_degree":9,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":10},{"id":"GO:0032496","count":7},{"id":"GO:0042572","count":6},{"id":"GO:0051409","count":4},{"id":"GO:0006116","count":4}]},{"hash":"1438169461980983458","title":"Actin Cytoskeleton Remodeling in Immune Response","description":"The top terms point to actin cytoskeleton organization and cell-matrix adhesion, paired with leukocyte chemotaxis and immune-related stimuli (LPS, prostaglandin), indicating the cluster centers on cytoskeletal remodeling linked to immune cell movement and signaling. Some terms (e.g., vagina development) may be noise, but the dominant theme is actin dynamics in immune contexts.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000251","count":3},{"id":"GO:0030866","count":3},{"id":"GO:0071222","count":3},{"id":"GO:0035372","count":3},{"id":"GO:0071333","count":2}]},{"hash":"175042641411954489","title":"Epigenetic Regulation of Development","description":"The strongest signals are chromatin remodeling and transcriptional control (negative regulation of transcription by RNA polymerase II; DNA-templated transcription; chromatin remodeling), pointing to epigenetic regulation of gene expression. The accompanying differentiation terms \u2014 oligodendrocyte differentiation, megakaryocyte differentiation, lung smooth muscle development, bronchus cartilage development \u2014 plus cell growth, suggest these proteins collectively coordinate developmental programs across multiple lineages by modulating chromatin state and transcription during development.","confidence":"High","size":14,"edges":16,"triangles":1,"max_degree":4,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0006351","count":4},{"id":"GO:0016049","count":3},{"id":"GO:0048709","count":3},{"id":"GO:0043044","count":3}]},{"hash":"78414385984284265","title":"Platelet activation and coagulation signaling","description":"The top GO terms point to platelet activation and blood coagulation as the core functions, with supportive signaling through ERK cascade regulation. While there are auxiliary terms related to calcium handling, transcription, and muscle/synaptic processes, the dominant theme across the cluster is platelet-mediated hemostasis and coagulation signaling.","confidence":"Medium","size":14,"edges":17,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0006368","count":1},{"id":"GO:0048096","count":1}]},{"hash":"928755326170513218","title":"RNA processing and translation initiation machinery","description":"Proteins here cluster around RNA metabolism: mRNA processing (splicing, polyadenylation, export, stabilization) and translation initiation (preinitiation complex formation, reinitiation), with aspects of ribosome biogenesis (small-subunit processome assembly).","confidence":"High","size":14,"edges":36,"triangles":32,"max_degree":12,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0006378","count":7},{"id":"GO:0002188","count":6},{"id":"GO:0001731","count":6},{"id":"GO:0045292","count":6},{"id":"GO:1902625","count":5}]},{"hash":"743380309395107433","title":"Synaptic signaling and plasticity regulation","description":"The cluster shows strong representation of neuronal signaling and plasticity terms, including negative regulation of protein kinase activity, regulation of long-term potentiation, and regulation of postsynaptic calcium concentration, which point to modulation of synaptic strength. Additional GO terms like miRNA processing regulation and protein methylation suggest accompanying gene-expression and epigenetic regulatory layers often linked with synaptic plasticity. While there are related terms for glucocorticoid response and muscle contraction, the dominant theme appears to be signaling control and plasticity in neural contexts.","confidence":"Medium","size":14,"edges":82,"triangles":275,"max_degree":13,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006469","count":13},{"id":"GO:1903799","count":12},{"id":"GO:1900271","count":12},{"id":"GO:2001015","count":12},{"id":"GO:0099566","count":12}]},{"hash":"2094201286968076637","title":"Quinone biosynthesis and energy metabolism","description":"The GO terms point to quinone biosynthesis (menaquinone and phylloquinone) combined with central energy pathways (glycolysis, TCA cycle, fatty acid beta-oxidation) and catabolic processes, indicating a metabolic module tied to energy production and redox cofactors. The presence of antibiotic biosynthesis and oxidative stress response terms appears supplementary rather than central, but do not override the core energy/quinone theme. Confident that this cluster represents metabolism linked to quinone production and energy generation. ","confidence":"High","size":14,"edges":90,"triangles":352,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":9},{"id":"GO:0009234","count":8},{"id":"GO:0042372","count":8},{"id":"GO:0006574","count":8},{"id":"GO:0010124","count":8}]},{"hash":"1082611939616224950","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060037","count":2},{"id":"GO:0001746","count":2},{"id":"GO:0032733","count":2},{"id":"GO:0032715","count":2},{"id":"GO:0008584","count":2}]},{"hash":"588859467279150753","title":"Angiogenesis and hematopoietic signaling","description":"This cluster is dominated by GO terms related to blood vessel formation and endothelial cell migration (angiogenesis, endothelial migration), coupled with signaling pathways driven by growth factors and receptors (PDGF stimulus, Kit signaling, integrin signaling) and hematopoietic/immune functions (hemopoiesis, B cell differentiation and B cell receptor signaling). The recurring theme around angiogenic and hematopoietic/immune signaling suggests a cohesive module coordinating vascular development with immune cell signaling. ","confidence":"High","size":14,"edges":10,"triangles":1,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001525","count":11},{"id":"GO:0070374","count":11},{"id":"GO:0043536","count":11},{"id":"GO:0030097","count":10},{"id":"GO:0007229","count":10}]},{"hash":"50972923701707021","title":"Unknown","description":"Unknown","confidence":"","size":14,"edges":43,"triangles":68,"max_degree":13,"top_function":null,"top_go_terms":[{"id":"GO:0033617","count":4},{"id":"GO:0032543","count":2},{"id":"GO:0051084","count":2},{"id":"GO:0022417","count":2},{"id":"GO:0045041","count":2}]},{"hash":"339242065610148818","title":"Neural development under hormonal and inflammatory cues","description":"The top GO terms include axon guidance and synapse assembly (GO:0021972, GO:0051965), pointing to neural development, while inflammatory and endocrine signals (inflammatory response, prostaglandin biosynthetic process, response to cortisol, response to vitamin D) suggest modulation by hormonal/inflammatory cues. This combination implies proteins coordinate neural wiring under hormonal and inflammatory contexts.","confidence":"High","size":14,"edges":8,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0055114","count":8},{"id":"GO:0033280","count":7},{"id":"GO:0001516","count":7},{"id":"GO:0051414","count":7},{"id":"GO:0006954","count":7}]},{"hash":"1776740458775367838","title":"Mitotic Division and Chromosome Alignment","description":"This cluster is dominated by GO terms for cell division and mitotic processes (mitotic cell cycle, exit from mitosis, and chromosome alignment), plus protein heterooligomerization indicating assembly of mitotic protein complexes. A few terms about neuron development or embryonic shape appear incidental noise. Overall, the proteins appear to function as a mitosis/division machinery module.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0051291","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0030206","count":2},{"id":"GO:0015015","count":2}]},{"hash":"1549122956208485082","title":"Mitochondrial Respiratory Chain Assembly & Redox Homeostasis","description":"The terms point to assembly of mitochondrial respiratory chain complexes I and IV, together with cellular redox homeostasis and oxidant detoxification, suggesting a cohesive role in mitochondrial respiration and oxidative stress protection; the transcription-related terms appear incidental to this core theme.","confidence":"High","size":14,"edges":15,"triangles":2,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0033617","count":2},{"id":"GO:0045454","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0032981","count":1}]},{"hash":"1546708660596846006","title":"Proteoglycan biosynthesis and tissue development","description":"This cluster is dominated by glycosaminoglycan/proteoglycan biosynthetic processes (heparan sulfate, dermatan sulfate, and proteoglycan biosynthesis) and tissue development terms (digestive tract, uterus, and female gonad development). Together, these suggest a coherent theme around extracellular matrix proteoglycans shaping developmental contexts, with auxiliary metabolic terms that are secondary. ","confidence":"Medium","size":14,"edges":15,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0048565","count":4},{"id":"GO:0008585","count":4},{"id":"GO:0060065","count":4},{"id":"GO:0045600","count":4},{"id":"GO:0006805","count":4}]},{"hash":"2125297215520144181","title":"Nuclear chromatin organization and nucleolus biogenesis","description":"This cluster centers on nuclear processes: nucleosome assembly, heterochromatin organization, and nucleosome-related chromatin functions, plus nucleologenesis and ribosome biogenesis. Together these GO terms point to chromatin architecture and the nucleolus-driven production of ribosomes, suggesting a coherent theme of genome organization linked to ribosome assembly. Despite zero edges in this network, the functions are cohesive around chromatin structure and nucleolar biogenesis.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016584","count":1},{"id":"GO:0071169","count":1},{"id":"GO:0097298","count":1},{"id":"GO:0080182","count":1},{"id":"GO:0006334","count":1}]},{"hash":"2274095555098929543","title":"Unknown","description":"The top GO terms cover both immune signaling (cytokine/chemokine regulation, B cell apoptotic processes) and cardiac electrophysiology/contractility (atrial action potential, calcium-regulated contraction). With no interactions among proteins (edges 0) and no cohesive, single biological process tying them together, there isn\u2019t a clear common function to label the cluster beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046330","count":1},{"id":"GO:0001783","count":1},{"id":"GO:0086014","count":1},{"id":"GO:2000341","count":1},{"id":"GO:0045083","count":1}]},{"hash":"1117501321382439378","title":"Melanin biosynthesis and pigmentation","description":"This cluster is dominated by GO terms tied to melanosome organization and melanin production (melanin biosynthetic process, pigmentation, and positive regulation of melanin biosynthesis), indicating proteins involved in pigmentation pathways. Other terms like proteolysis or neural progenitor proliferation appear less central and may reflect multifunctional proteins, but the pigmentation signal is the strongest theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006508","count":2},{"id":"GO:0021847","count":1},{"id":"GO:0032438","count":1},{"id":"GO:0006583","count":1},{"id":"GO:0043473","count":1}]},{"hash":"1726121951136618200","title":"Developmental Morphogenesis and Immune Signaling","description":"The label captures the mix of GO terms tied to developmental morphogenesis (salivary gland branching, lens fiber differentiation, olfactory placode morphogenesis, axon guidance) together with immune-related signaling (NF-kappaB regulation, leukocyte aggregation, erythropoietin-mediated signaling). The proteins seem to participate in broad signaling pathways rather than a single process, explaining the diverse annotations.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":3},{"id":"GO:0060665","count":2},{"id":"GO:0035584","count":2},{"id":"GO:0050925","count":2},{"id":"GO:0070486","count":2}]},{"hash":"1320041602764151685","title":"Unknown","description":"The GO terms show a broad mix: energy metabolism (mitochondrial ATP synthase complex assembly), light-responsive signaling (far-red light pathways, phototransduction), transcription regulation, circadian rhythm, innate immunity, mitosis, apoptosis and pyroptosis. With no edges and no consistent functional cluster, there isn't a single cohesive theme to name it; label Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033615","count":1},{"id":"GO:0042753","count":1},{"id":"GO:0010018","count":1},{"id":"GO:0006355","count":1},{"id":"GO:0009585","count":1}]},{"hash":"4988002769429668","title":"Dopaminergic GPCR Signaling and Uptake","description":"The cluster is dominated by GO terms centered on dopaminergic signaling and GPCR pathways, notably the adenylate cyclase-activating dopamine receptor signaling pathway and positive regulation of dopamine uptake. This points to a coherent theme of dopaminergic neurotransmission and GPCR-mediated signal transduction, with additional terms involving prostaglandin responses and astrocyte chemotaxis suggesting broader neuroglial signaling interactions that connect to GPCR signaling networks. Overall, the terms consistently point to a dopaminergic signaling module as the core function of this cluster.","confidence":"High","size":14,"edges":5,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":12},{"id":"GO:1900135","count":12},{"id":"GO:2000458","count":12},{"id":"GO:1901652","count":12},{"id":"GO:0018298","count":12}]},{"hash":"428743654100025601","title":"Neuronal development and synaptic plasticity","description":"The terms point to neuronal functions: social behavior, nervous system development, and long-term synaptic depression, indicating neuronal development and synaptic plasticity; microtubule-based movement supports axonal transport and neurite growth; some general terms like ribosome biogenesis and cell division may reflect broad cellular activity in developing neurons rather than a separate theme.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035176","count":3},{"id":"GO:0007018","count":2},{"id":"GO:0000278","count":2},{"id":"GO:0007399","count":2},{"id":"GO:2001108","count":2}]},{"hash":"1240498330720679715","title":"Innate Immune Signaling and Cytokine Regulation","description":"The top GO terms point to innate immune pathways and cytokine control, including TLR9 signaling, defense against Gram-negative bacteria, and regulation of IL-6, IL-17, and CXCL2 production, along with JNK pathway modulation and B cell apoptosis. While some terms (anoxia, chloroquine, cardiac action potential) reflect broader cellular stress responses, the dominant theme across terms is immune activation and cytokine signaling.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071454","count":2},{"id":"GO:0032700","count":1},{"id":"GO:0046330","count":1},{"id":"GO:0001783","count":1},{"id":"GO:0034162","count":1}]},{"hash":"336598728541816994","title":"Dopamine Receptor Signaling and Synaptic Modulation","description":"The top GO terms cluster around dopamine receptor signaling that activates adenylate cyclase, regulation of dopamine uptake, and downstream GPCR/GTPase-related pathways affecting synaptic transmission, with additional links to astrocyte chemotaxis and prostaglandin responses. This points to a cohesive theme of dopaminergic signaling and its modulation by both neuronal and glial components, reflecting a neuroglial signaling module centered on dopamine-mediated synaptic activity.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":13},{"id":"GO:1900135","count":13},{"id":"GO:2000458","count":13},{"id":"GO:1901652","count":13},{"id":"GO:0018298","count":13}]},{"hash":"1258224521916615440","title":"Dopamine receptor signaling and ERK cascade","description":"The GO terms point mainly to dopaminergic GPCR signaling, including positive regulation of dopamine uptake and dopamine receptor signaling, along with downstream ERK1/2 cascade activation and phosphoinositide biosynthesis regulation, suggesting a cohesive theme of dopamine-driven signal transduction and kinase signaling, with some peripheral terms hinting at broader secretory and glial response contexts.","confidence":"Medium","size":14,"edges":2,"triangles":0,"max_degree":1,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0051586","count":7},{"id":"GO:0008283","count":7},{"id":"GO:0070374","count":7},{"id":"GO:0010513","count":7},{"id":"GO:0030168","count":6}]},{"hash":"1295584995761487390","title":"Nervous system development and myelination","description":"The top GO terms center on neural development and maturation\u2014peripheral nervous system development, myelination, synapse organization, and SHH signaling\u2014with additional hints from potassium channel clustering and heart development. This pattern points to processes governing neuronal differentiation, connectivity, and myelin formation, making a nervous system development/maturation theme the most representative for the cluster.","confidence":"High","size":14,"edges":29,"triangles":17,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007275","count":10},{"id":"GO:0045663","count":9},{"id":"GO:0042552","count":9},{"id":"GO:0007422","count":9},{"id":"GO:0007224","count":9}]},{"hash":"2082232271316055712","title":"Cardiac Temperature Response and Electrophysiology","description":"The cluster's GO terms include several temperature-related processes (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis, vasoconstriction) alongside cardiac electrophysiology terms (membrane depolarization/repolarization in atrial and AV node cells, regulation of atrial action potential, and stress-induced cardiac hypertrophy). This suggests proteins involved in linking thermal cues to heart rhythm and vascular tone, hence a label that emphasizes temperature response in a cardiac electrophysiology context.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":9},{"id":"GO:0002024","count":9},{"id":"GO:0071502","count":9},{"id":"GO:0098914","count":7},{"id":"GO:0021750","count":7}]},{"hash":"1318337945445886865","title":"Embryonic organogenesis and eye development","description":"These GO terms cluster around embryonic development across multiple organs\u2014eye morphogenesis, neural/ganglion development, somite formation, and heart tube patterning\u2014suggesting a general embryogenesis program rather than a single pathway. A concise label capturing this theme is Embryonic organogenesis and eye development.","confidence":"High","size":14,"edges":24,"triangles":0,"max_degree":8,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0007275","count":12},{"id":"GO:0021759","count":11},{"id":"GO:0072075","count":9},{"id":"GO:0061551","count":9},{"id":"GO:0031290","count":8}]},{"hash":"2160112557276340071","title":"Epidermal development and inflammatory signaling","description":"The top terms point to skin-related development (keratinocyte differentiation, hair follicle morphogenesis, planar polarity) and tissue organization, complemented by immune signaling (lipopolysaccharide- and IL-1-mediated pathways) and stress responses, suggesting a cluster centered on epidermal development with associated signaling contexts, plus some broader stress/damage responses.","confidence":"Medium","size":14,"edges":20,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031663","count":3},{"id":"GO:0001736","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0071479","count":2},{"id":"GO:0030216","count":2}]},{"hash":"1241896090120715068","title":"Unknown","description":"The top GO terms are highly heterogeneous, including muscle contraction (esophagus), epithelial migration (colon), innervation, developmental processes, coagulation, and even bacterial lipoteichoic acid biosynthesis, with no clear shared pathway or function connecting them. There are no edges or triangles, suggesting the proteins do not converge on a single coherent biological theme; thus no reliable cluster label beyond Unknown.","confidence":"","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014846","count":3},{"id":"GO:0090305","count":3},{"id":"GO:0060686","count":3},{"id":"GO:0070395","count":3},{"id":"GO:0040037","count":3}]},{"hash":"2060440568708125419","title":"Developmental transcriptional regulation and metabolism","description":"The cluster highlights transcriptional regulation during development (negative regulation of RNA Pol II, pituitary gland and multicellular organism development, primitive streak formation) along with metabolic/mitochondrial processes (dihydrolipoamide metabolism, mitochondrial electron transport). Some stress-response terms are present, but the core theme appears to be developmental gene regulation tied to metabolism.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":7},{"id":"GO:0021983","count":4},{"id":"GO:0043046","count":4},{"id":"GO:0032496","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1511542167715128888","title":"RNA and protein methylation in biosynthetic pathways","description":"The top GO terms cluster around RNA methylation (rRNA/tRNA methylation, rRNA modification) and various protein methylations (peptidyl-lysine dimethylation, N-terminal trimethylation, peptidyl-glutamine methylation), alongside several biosynthetic processes (antibiotic, cobalamin, biotin biosynthesis). This points to a cohesive theme of methyltransferase-driven modifications embedded in diverse biosynthetic pathways, explaining the cluster\u2019s composition.","confidence":"High","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":8},{"id":"GO:0009236","count":7},{"id":"GO:0016049","count":7},{"id":"GO:0018027","count":7},{"id":"GO:0009102","count":7}]},{"hash":"2244558693801213728","title":"Glycan biosynthesis and carbohydrate metabolism","description":"The top GO terms cluster around carbohydrate-related synthesis and metabolism, including lipopolysaccharide biosynthesis, N-acetylglucosamine and neuraminic acid biosynthesis, and general carbohydrate metabolic processes. A few outliers (ion transport and calcium homeostasis) exist, but the dominant theme is glycans and related lipid/carbohydrate metabolism, suggesting the proteins function in glycan assembly and carbohydrate metabolism pathways.","confidence":"High","size":14,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006874","count":2},{"id":"GO:0007341","count":2},{"id":"GO:0009103","count":1},{"id":"GO:0046295","count":1},{"id":"GO:0006564","count":1}]},{"hash":"2009114176264185839","title":"Immune signaling and actin cytoskeleton remodeling","description":"The strongest terms cluster around immune signaling (immunological synapse formation, LPS-mediated signaling, response to yeast) and cytoskeletal dynamics (lamellipodium morphogenesis, GTPase activity regulation), suggesting proteins that coordinate immune signaling with actin remodeling. Some terms are broader or indirect (insulin signaling, behavior), but the core theme remains immune signaling linked to cytoskeletal changes.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008286","count":3},{"id":"GO:0050894","count":2},{"id":"GO:2000821","count":2},{"id":"GO:0035156","count":2},{"id":"GO:0043547","count":2}]},{"hash":"98001910278133199","title":"Neural signaling and behavior","description":"Top GO terms indicate signaling pathway regulation (ERK cascade, Rho signaling, IGF receptor signaling) and neural/behavioral phenotypes (locomotory behavior, visual learning, response to amphetamine). Heart development and vasoconstriction are cardiovascular-related terms that may reflect shared signaling networks rather than a single function. Taken together, the cluster appears to group proteins involved in signaling affecting neural function and behavior.","confidence":"Medium","size":14,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007507","count":3},{"id":"GO:0070374","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0007626","count":3},{"id":"GO:0001975","count":3}]},{"hash":"1137574729608979884","title":"Viral infection and replication cycle","description":"The enriched GO terms center on stages of the viral life cycle\u2014entry and membrane fusion, uncoating, virion assembly, and proviral latency\u2014with supporting host-process terms (lipid droplets, leukocyte migration, splicing) that viruses commonly exploit during infection. This suggests the cluster captures viral infection/replication machinery and virus\u2013host interactions.","confidence":"Medium","size":13,"edges":10,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1901407","count":3},{"id":"GO:0000398","count":3},{"id":"GO:0019064","count":2},{"id":"GO:0030260","count":2},{"id":"GO:0019068","count":2}]},{"hash":"1367805420954928613","title":"ECM Signaling in Cartilage Development","description":"The top GO terms point to collagen-activated signaling, cartilage condensation, and enhanced cell-matrix adhesion, all indicative of extracellular matrix\u2013mediated communication driving developmental processes, especially cartilage formation, with supportive MAPK signaling. Other terms suggest broader signaling roles but do not override this ECM-development theme.","confidence":"Medium","size":13,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0046827","count":7},{"id":"GO:0038063","count":5},{"id":"GO:0001502","count":5},{"id":"GO:1904780","count":5},{"id":"GO:0071333","count":4}]},{"hash":"1198404838659327276","title":"Unknown","description":"Unknown","confidence":"","size":13,"edges":77,"triangles":275,"max_degree":12,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006986","count":10},{"id":"GO:0070389","count":10},{"id":"GO:0036494","count":10},{"id":"GO:0006469","count":10},{"id":"GO:0030433","count":9}]},{"hash":"923636878985895413","title":"GPCR-mediated cAMP/cGMP signaling","description":"The cluster is dominated by G protein-coupled receptor signaling terms, especially adenosine receptor pathways, with strong links to intracellular signaling via cAMP and cGMP produced by adenylate and guanylyl cyclases. The presence of forskolin response and cGMP biosynthesis terms supports a cohesive GPCR-driven second messenger signaling module, likely influencing downstream transcription or cellular responses.","confidence":"High","size":13,"edges":8,"triangles":2,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001973","count":10},{"id":"GO:0035556","count":10},{"id":"GO:0006182","count":10},{"id":"GO:0007168","count":10},{"id":"GO:1900194","count":10}]},{"hash":"1305028683922517909","title":"Developmental transcriptional regulation","description":"Based on the prominence of DNA-templated transcription (GO:0006351) and multiple development-related terms across nervous system, skin, and reproductive tissues (brain, spinal cord, skin, mesonephric duct, male gonad development) plus a note of growth regulation, the cluster likely comprises proteins involved in regulating gene expression during development. Some ancillary terms like tRNA processing or telomere maintenance appear but are secondary to the developmental transcriptional theme.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0021510","count":2},{"id":"GO:0043588","count":2},{"id":"GO:0007420","count":2},{"id":"GO:0008284","count":2}]},{"hash":"16854915493210837","title":"Embryonic organ morphogenesis","description":"This cluster shows several GO terms tied to embryonic development across multiple organs (eye morphogenesis, pituitary gland development, in utero development, lung morphogenesis) rather than a single pathway, suggesting a general role in early organ formation. Confidence: Medium","confidence":"","size":13,"edges":64,"triangles":160,"max_degree":12,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0009236","count":5},{"id":"GO:0021983","count":5},{"id":"GO:0048048","count":5},{"id":"GO:0060441","count":5},{"id":"GO:0006366","count":5}]},{"hash":"2220292809603182412","title":"Mitochondrial Transport and Metabolism","description":"The cluster centers on mitochondrial transport of ATP, citrate, CoA, and metal ions, with links to nutrient sensing (amino acid starvation, insulin signaling) and mitochondrial stress/apoptosis, suggesting a mitochondria-focused energy metabolism module.","confidence":"High","size":13,"edges":27,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0034198","count":3},{"id":"GO:0032869","count":3},{"id":"GO:0007420","count":2},{"id":"GO:0006605","count":2},{"id":"GO:0035435","count":2}]},{"hash":"381060920505433922","title":"Post-transcriptional RNA processing and turnover","description":"The cluster shows strong signals for post-transcriptional RNA metabolism: spliceosome-based mRNA splicing and its regulation, mRNA catabolic processes, and regulation of mRNA stability in response to stress, along with miRNA turnover. These themes point to a cohesive function in RNA processing and degradation, with a few outliers (neuronal activity regulation, chemotropism) possibly reflecting broader roles of involved proteins. ","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":7},{"id":"GO:0048024","count":6},{"id":"GO:0098908","count":5},{"id":"GO:0006402","count":5},{"id":"GO:0043577","count":5}]},{"hash":"1548860178288393034","title":"DNA damage response and repair","description":"This cluster is dominated by GO terms tied to DNA damage sensing and repair: SOS response, nucleotide-excision repair, DNA-templated DNA replication, and DNA recombination, indicating a common theme of DNA maintenance and damage response. A lone translation term and the symbiont-mediated host expression term are incidental but do not override the central DNA-processing theme. Overall, the proteins appear to participate in DNA repair and replication processes rather than broader signaling or translation. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":1},{"id":"GO:0009432","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0006261","count":1},{"id":"GO:0006310","count":1}]},{"hash":"1482932221134774193","title":"Neural development and axon guidance","description":"The top GO terms cluster around neural development: retinal ganglion cell axon guidance, optic nerve morphogenesis, corpus callosum development, and dendritic spine morphogenesis, indicating neural patterning and axon pathfinding. Integrin-mediated adhesion further supports a neural tissue development theme. Some immune-related terms are present but less central to the core signal.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:2000271","count":2},{"id":"GO:0060997","count":2},{"id":"GO:0048320","count":2},{"id":"GO:0031290","count":2}]},{"hash":"2207619678436198353","title":"Protein Translation Machinery","description":"The cluster is dominated by translation-related GO terms (translation and translational elongation), pointing to a group of proteins involved in protein synthesis. Other terms (developmental and mitochondrion-related) appear less consistently, suggesting translation as the core function with some incidental associations.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0006626","count":2},{"id":"GO:0006414","count":1},{"id":"GO:0042572","count":1},{"id":"GO:0003007","count":1}]},{"hash":"737395221985969058","title":"MAPK signaling and metabolic regulation","description":"The cluster\u2019s top GO terms center on signaling and stress-response pathways (cell integrity MAPK cascade, cellular responses to glucose and prostaglandin stimuli, osmosensory signaling) alongside metabolic processes (cholesterol biosynthesis) and cell-architecture interactions (cell-matrix adhesion, budding growth). This points to a cohesive theme where MAPK-driven signaling coordinates metabolic state, stress responses, and structural/adhesive functions. Hence the label MAPK signaling and metabolic regulation. ","confidence":"Medium","size":13,"edges":47,"triangles":71,"max_degree":11,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071333","count":13},{"id":"GO:0001954","count":13},{"id":"GO:0002688","count":13},{"id":"GO:0000196","count":13},{"id":"GO:0060068","count":13}]},{"hash":"1806606508226409759","title":"Regulation of cell signaling and transcription","description":"This cluster centers on regulatory processes across signaling pathways (e.g., Rac/Rho signaling, LPS signaling, JNK activity) and transcription control (negative regulation of RNA Pol II), with additional context in vitamin D response and spermatid differentiation. The shared theme is modulation and regulation rather than a single pathway, justifying this label as representative, though it covers diverse contexts. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0046232","count":2},{"id":"GO:0007289","count":2},{"id":"GO:0035021","count":2},{"id":"GO:0031666","count":2}]},{"hash":"134128538378141547","title":"Retinoid metabolism and developmental processes","description":"Most prominent terms are retinol metabolic process and retinal metabolic process (11 each), indicating a core theme of retinoid metabolism. The cluster also includes multiple developmental terms across organs (heart morphogenesis, cardiac muscle tissue development, Harderian gland development, nucleus accumbens development, pituitary gland development, bilateral symmetry determination), suggesting retinoid signaling links to broader organogenesis and neural development. Overall, it points to a cohesive theme around retinoid metabolism coordinating development, hence the proposed label.","confidence":"Medium","size":13,"edges":78,"triangles":286,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0042572","count":11},{"id":"GO:0042574","count":11},{"id":"GO:0003007","count":6},{"id":"GO:0070384","count":6},{"id":"GO:0032180","count":6}]},{"hash":"1578986222214661886","title":"Unknown","description":"The terms cover sensory perception (thermoception, pain) and calcium-related signaling (calcium import, capsazepine response), but also include unrelated processes (spindle assembly, mRNA processing, IL-12 regulation, telomere maintenance, endothelial differentiation). There is no single cohesive function linking all terms, so a specific label cannot be confidently assigned.","confidence":"","size":13,"edges":11,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0051225","count":3},{"id":"GO:0050960","count":3},{"id":"GO:0050968","count":3},{"id":"GO:0098703","count":3},{"id":"GO:1901594","count":3}]},{"hash":"1477613659822392224","title":"Neural development and brain region differentiation","description":"The terms cluster around transcriptional regulation and differentiation of neural lineages across various brain regions (olfactory bulb, locus ceruleus, hypothalamus, spinal cord) and related neuromuscular and behavioral processes, suggesting a coherent neural development theme; the ectoderm/endoderm terms reflect early lineage specification compatible with neural origin.","confidence":"High","size":13,"edges":6,"triangles":0,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006355","count":4},{"id":"GO:0042663","count":4},{"id":"GO:0021889","count":4},{"id":"GO:0050905","count":4},{"id":"GO:0021703","count":4}]},{"hash":"1873918421023323501","title":"Cell wall remodeling and chitin/peptidoglycan metabolism","description":"Most of the top GO terms cluster around cell wall components and their turnover\u2014peptidoglycan and chitin catabolic/biosynthetic processes, cell wall organization, and regulation of cell shape. This suggests a shared function in cell wall remodeling and morphogenesis, with sporulation aligning to a broader developmental change and the other terms representing related structural/receptor dynamics. The presence of an outlier term about fibroblast migration does not outweigh the overarching theme of cell wall dynamics.","confidence":"Medium","size":13,"edges":13,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010763","count":2},{"id":"GO:0071323","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0009253","count":1},{"id":"GO:0016998","count":1}]},{"hash":"1257229162254435480","title":"Embryonic morphogenesis and neural crest migration","description":"The top GO terms cluster around embryonic development and migratory processes\u2014embryonic morphogenesis, kidney development, ventral trunk neural crest cell migration, axon guidance, BMP signaling, and cell adhesion\u2014indicating a developmental and migratory program. A few immune-related terms appear but are less central, suggesting the core function is tissue patterning and neural crest\u2013driven development rather than immunity.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001822","count":2},{"id":"GO:0071639","count":2},{"id":"GO:0007411","count":2},{"id":"GO:0045087","count":2},{"id":"GO:0045663","count":2}]},{"hash":"324308942916001446","title":"Broad Stimulus-Response Signaling","description":"The top GO terms cover a range of signaling and responses to stimuli across different cell types, including mechanical stress, JNK/MAPK signaling, apoptosis, immune cell movement, and neural/reproductive processes. This breadth suggests a general theme of signal transduction in response to diverse cues rather than a single cohesive pathway, so a broad label is appropriate.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0071260","count":5},{"id":"GO:0046330","count":4},{"id":"GO:0097284","count":4},{"id":"GO:0042088","count":3},{"id":"GO:0043552","count":3}]},{"hash":"1541615267185977753","title":"Dopaminergic GPCR Signaling and Synaptic Modulation","description":"This cluster is dominated by GO terms tied to dopamine receptor signaling via adenylate cyclase (GO:0007191), dopamine uptake regulation, and GPCR-mediated pathways, with additional hints of neural-glial interactions (astrocyte chemotaxis) and broader peptide-responsive signaling. Together these indicate a coherent theme around dopaminergic signaling and its modulation at synapses, with some supporting downstream processes like GTPase activity regulation. ","confidence":"High","size":13,"edges":39,"triangles":31,"max_degree":8,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":12},{"id":"GO:1900135","count":12},{"id":"GO:2000458","count":12},{"id":"GO:1901652","count":12},{"id":"GO:0018298","count":12}]},{"hash":"1024374503300947702","title":"Nitric oxide and ROS response in blood vessels","description":"This set points to nitric oxide and oxidative stress management in blood vessels, including NO transport, hydrogen peroxide response, and vascular homeostasis (vasodilation and coagulation). The erythrocyte differentiation term hints at red blood cell development linked to these pathways, while endocytosis and protein oligomerization suggest supporting signaling roles. ","confidence":"Medium","size":13,"edges":10,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0051409","count":4},{"id":"GO:0043353","count":4},{"id":"GO:0050880","count":4},{"id":"GO:0010942","count":4},{"id":"GO:0042744","count":4}]},{"hash":"1663695861271582183","title":"Neuronal synaptic vesicle cycling and ERK signaling","description":"These terms indicate a module centered on neuronal vesicle trafficking and signaling: presynaptic exocytosis, vesicle priming, ubiquitin-dependent endocytosis, and simultaneous engagement of ERK pathway regulation, alongside brain development. The cluster likely represents proteins involved in synaptic vesicle cycling and neuronal signal transduction, with some broader developmental and secretory links.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070086","count":2},{"id":"GO:0007420","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0007343","count":1}]},{"hash":"1237925224997729877","title":"Developmental signaling and differentiation","description":"The top GO terms cluster around developmental signaling and tissue differentiation (Smoothened and Roundabout pathways, axon guidance, kidney and nervous system development, melanocyte differentiation, ossification, mast cell chemotaxis, spermatid development, and ERK1/2 cascade regulation), suggesting a cohesive theme of signaling pathways guiding development across multiple tissues. This label captures the broad, cross-tissue developmental signaling theme represented by the cluster.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007224","count":5},{"id":"GO:0001822","count":5},{"id":"GO:0007399","count":5},{"id":"GO:0007411","count":4},{"id":"GO:0030318","count":4}]},{"hash":"228118302290683245","title":"Immune Signaling and Muscle Development Regulators","description":"The cluster contains immune-related GO terms (B cell receptor signaling, pro-T cell differentiation, mast cell cytokine production) alongside skeletal muscle development terms and core regulatory processes (GTPase activity regulation and ubiquitin-dependent protein catabolic process). This suggests a theme of signaling with regulated protein turnover affecting immune and muscle biology, with a noisy gravitropism term that seems unrelated. Therefore the label reflects the main shared functions, albeit with some mixed terms.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":12,"top_function":null,"top_go_terms":[{"id":"GO:0009958","count":3},{"id":"GO:0018298","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0007519","count":2},{"id":"GO:0032764","count":2}]},{"hash":"53444176651705296","title":"Leukocyte Extravasation and ECM Remodeling","description":"This cluster is enriched for immune- and ECM-related processes: integrin signaling and T cell activation point to immune cell engagement; cellular extravasation captures leukocyte movement; hyaluronan metabolism, ECM assembly regulation, and metallopeptidase activity indicate ECM remodeling; a cartilage morphogenesis term and regeneration term suggest broader tissue remodeling. The dominant theme is leukocyte adhesion/migration and extracellular matrix remodeling.","confidence":"High","size":13,"edges":19,"triangles":6,"max_degree":9,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0007229","count":10},{"id":"GO:0002291","count":10},{"id":"GO:0030212","count":10},{"id":"GO:0003429","count":7},{"id":"GO:0045123","count":7}]},{"hash":"501284496652441722","title":"Dopaminergic signaling and retinal development with glial response","description":"The top terms cluster around neural signaling and eye development (dopamine receptor signaling, retina development) and glial/inflammatory responses (astrocyte chemotaxis, prostaglandin response). While there are broader terms like GTPase regulation and cell proliferation, the strongest cohesive theme is neural signaling tied to retina development with glial involvement.","confidence":"Medium","size":13,"edges":42,"triangles":57,"max_degree":12,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0043547","count":9},{"id":"GO:0008283","count":9},{"id":"GO:0008284","count":9},{"id":"GO:0060041","count":9},{"id":"GO:0007191","count":8}]},{"hash":"1561745935835747194","title":"Unknown","description":"The listed GO terms are highly diverse, ranging from antiviral regulation and innate mucosal immunity to bone/retina processes and iron metabolism, with only one annotation per term and no edges. There is no clear shared function linking the cluster, so a specific, representative label cannot be derived.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045071","count":1},{"id":"GO:0051092","count":1},{"id":"GO:2001205","count":1},{"id":"GO:0002227","count":1},{"id":"GO:0001503","count":1}]},{"hash":"822500802961205177","title":"Embryonic neural, lens, and skeletal development","description":"The top GO terms point to developmental programs across neural and sensory tissues (synapse organization, neuron projection development, lens fiber differentiation) as well as mesoderm-derived structures (paraxial mesoderm development, skeletal system development). This suggests a coherent theme of embryonic tissue development rather than a single function. Other terms (defense response, transcription regulation, GTPase activity) may reflect background or regulatory roles.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":4},{"id":"GO:0050808","count":3},{"id":"GO:0048339","count":3},{"id":"GO:0042742","count":3},{"id":"GO:0070306","count":3}]},{"hash":"1552754864234654091","title":"Neural signaling and collagen maturation","description":"The top GO terms show strong emphasis on neuronal communication (positive regulation of nerve impulse transmission, serotonin receptor signaling) and ion transport (potassium and calcium), suggesting neural activity. The presence of collagen-related terms (collagen fibril organization and prolyl hydroxylation to 4-hydroxy-L-proline) points to collagen maturation and extracellular matrix remodeling, which can accompany neural tissue contexts or connective-tissue interactions. While a few terms touch on development or apoptosis, the dominant pattern is neural signaling with supporting collagen maturation processes, justifying a combined label that reflects both themes.","confidence":"Medium","size":13,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0051971","count":2},{"id":"GO:0030199","count":2},{"id":"GO:0018401","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0071805","count":1}]},{"hash":"925963574424800079","title":"Dopaminergic Neuron Development and Signaling","description":"This cluster shows a cohesive emphasis on neural development and dopamine biology, with terms such as cellular response to dopamine, regulation of dopamine receptor signaling, neuron maturation, nerve branching morphogenesis, and modulation of synaptic activity. There are also immune and cell cycle terms present, but the dopamine-neuron theme appears most representative of the cluster.","confidence":"Medium","size":13,"edges":13,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0051301","count":4},{"id":"GO:0014041","count":4},{"id":"GO:0046677","count":3},{"id":"GO:0007049","count":3}]},{"hash":"211561274752036170","title":"Neuronal vesicle trafficking and immune signaling","description":"The dominant terms point to neuronal vesicle dynamics (regulation of synaptic vesicle exocytosis and endocytosis, excitatory postsynaptic potential), while immune-related terms (complement activation pathways and chemokine production) suggest immune signaling. The presence of angiogenesis and embryonic development hints at broader developmental roles that can intersect with neurodevelopment. Overall, the cluster appears to combine neuronal vesicle regulation with immune/developmental modulation.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0001525","count":3},{"id":"GO:0009933","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0060079","count":2}]},{"hash":"714827412186485577","title":"Ubiquitin-dependent proteolysis and innate immune signaling","description":"GO terms center on ubiquitin-dependent protein turnover (proteolysis, autoubiquitination, various ubiquitin linkages) and related signaling pathways, including innate immune response and NF-kappaB activation. A circadian rhythm term is present but appears secondary to the dominant ubiquitin-modulation theme. This supports a label focused on ubiquitin-mediated regulation in immune signaling.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":7},{"id":"GO:0045087","count":4},{"id":"GO:0030433","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0042752","count":3}]},{"hash":"1901817844590841180","title":"Unknown","description":"The GO terms are a mix of immune development (hematopoietic stem cell and T cell differentiation), cellular organization (ER, nucleolus, ribosomal export), and unrelated metabolic hints (maltose transport), with no clear shared pathway or interactions linking the proteins, so there is no cohesive function for the cluster.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071425","count":1},{"id":"GO:0033077","count":1},{"id":"GO:0046638","count":1},{"id":"GO:1903955","count":1},{"id":"GO:0030851","count":1}]},{"hash":"867114710995269197","title":"Cardiac conduction and calcium signaling","description":"These proteins are annotated with GO terms centered on cardiac electrical activity: regulation of atrial/ventricular depolarization and repolarization, AV node action potential, and heart rate regulation via conduction, plus calcium ion import across the membrane \u2014 all pointing to calcium-dependent cardiac excitation-contraction and rhythm control. Some terms like skin development and ossification are less related and may reflect broader roles or annotation noise, but the dominant theme is cardiac conduction and calcium signaling.","confidence":"High","size":13,"edges":12,"triangles":0,"max_degree":9,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0043588","count":6},{"id":"GO:0060371","count":4},{"id":"GO:0050960","count":4},{"id":"GO:0060307","count":4},{"id":"GO:0045188","count":4}]},{"hash":"1974598174793201740","title":"Notch-regulated development and differentiation","description":"This cluster is anchored by Notch signaling terms (positive regulation, involvement in secondary heart field cardioblast proliferation) and multiple differentiation-related processes (bone trabeculae formation, keratinocyte differentiation, negative regulation of photoreceptor differentiation), plus neural/embryonic context terms like paranodal junction assembly and embryo implantation. Additional terms about responses to hypoxia, mechanical stimulus, and vitamin D suggest environmental cues shaping developmental pathways across tissues. Overall, the proteins likely participate in Notch-driven development and tissue differentiation across several lineages.","confidence":"Medium","size":13,"edges":12,"triangles":0,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0045747","count":3},{"id":"GO:0071456","count":2},{"id":"GO:0060346","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0030913","count":2}]},{"hash":"118095832000052544","title":"Neuropeptide GPCR Signaling in Pain and Thermogenesis","description":"The GO terms cluster around pain perception, thermogenesis, and GPCR signaling (including adenylate cyclase-activating pathways and neuropeptide signaling), suggesting a module of neuropeptide-driven signaling that modulates sensory and metabolic responses, with ancillary links to energy metabolism and cardiovascular regulation.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":8},{"id":"GO:0002024","count":7},{"id":"GO:0071502","count":7},{"id":"GO:0010579","count":6},{"id":"GO:0007218","count":6}]},{"hash":"1446828183854480686","title":"Mitotic cell cycle and proliferation","description":"The cluster is dominated by mitosis- and proliferation-related terms: mitotic cell cycle, mitotic sister chromatid segregation, cell division, and positive regulation of cell population proliferation, plus microtubule severing\u2014together pointing to spindle dynamics and cell-cycle progression. Other terms like ER-to-Golgi transport and an outlier retina development term are present but less central, making the core theme around mitosis and growth.","confidence":"High","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0008283","count":5},{"id":"GO:0008284","count":5},{"id":"GO:0000278","count":5},{"id":"GO:0060041","count":4}]},{"hash":"843034878912957080","title":"Growth Factor Signaling in Morphogenesis","description":"The top GO terms point to signaling pathways that drive tissue development and morphogenesis, including hepatocyte growth factor receptor signaling, branching morphogenesis of salivary glands, mammary duct growth, and myoblast differentiation/proliferation, with involvement of p38 MAPK cascade regulation. Some terms on coagulation/fibrinolysis and cytokine production may reflect broader remodeling and immune signaling contexts during development. Overall, the cluster appears to represent growth-factor\u2013driven morphogenesis and muscle differentiation signals.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":2},{"id":"GO:0048012","count":2},{"id":"GO:0045445","count":2},{"id":"GO:1902947","count":2},{"id":"GO:0007596","count":2}]},{"hash":"2098241855144827760","title":"Unknown","description":"The top terms span neural plasticity, heart/muscle function, barrier biology, kidney development, and broad transcription regulation, with little overlap suggesting a single cohesive function. There isn\u2019t a clear shared process tying these proteins together, so a specific label isn\u2019t justifiable. ","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008065","count":2},{"id":"GO:1902083","count":2},{"id":"GO:1900271","count":1},{"id":"GO:0035191","count":1},{"id":"GO:0098735","count":1}]},{"hash":"1702177421879475720","title":"Cardiac and endothelial development","description":"The top GO terms cluster around heart and vascular formation, including venous endothelial differentiation, cardiac right atrium morphogenesis, and Notch signaling in heart field progenitors, with broader development terms accompanying them. Despite a few unrelated terms, the dominant theme is heart/vascular development and endothelial differentiation, supporting this label.","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060843","count":6},{"id":"GO:0003270","count":6},{"id":"GO:0003213","count":6},{"id":"GO:0043547","count":4},{"id":"GO:0007205","count":4}]},{"hash":"2122598151918223750","title":"Coagulation and ECM remodeling with immune defense","description":"This cluster\u2019s top GO terms cluster around collagen catabolic processes and biomineral tissue development (ECM-related remodeling), along with blood coagulation and complement activation, plus defense responses to Gram-positive bacteria. Together these indicate a module integrating extracellular matrix remodeling, mineralized tissue processes, and hemostasis with innate immune defense. The negative regulation terms are peripheral but not dominant. ","confidence":"Medium","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044130","count":4},{"id":"GO:0031214","count":3},{"id":"GO:0030194","count":3},{"id":"GO:0030574","count":3},{"id":"GO:0001867","count":3}]},{"hash":"1936842687146006662","title":"Unknown","description":"The top terms span innate immune signaling, responses to bacterial components (LPS), unfolded protein response, photoreceptor outer segment localization, and cell cycle/centrosome processes, plus a mix of obsolete or less related terms. This mix does not reveal a single coherent biological theme tying all proteins together, making it inappropriate to assign a precise, specific label beyond Unknown.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045087","count":4},{"id":"GO:0008653","count":3},{"id":"GO:0006986","count":3},{"id":"GO:1903546","count":3},{"id":"GO:0051301","count":3}]},{"hash":"832642855391105740","title":"Unknown","description":"The GO terms cover microglia development, junction assembly, immune regulation, vesicle trafficking, signaling, and virion attachment with no single cohesive process linking them, suggesting the proteins have diverse, unrelated roles rather than a shared function.","confidence":"","size":13,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0014005","count":1},{"id":"GO:0090528","count":1},{"id":"GO:0030913","count":1},{"id":"GO:0030886","count":1},{"id":"GO:0071404","count":1}]},{"hash":"792487426051219730","title":"RNA processing and transcription regulation","description":"This cluster centers on RNA metabolism and transcription control, with terms such as regulation of RNAP II CTD phosphorylation, regulatory ncRNA-mediated gene silencing, positive regulation of mRNA splicing via the spliceosome, transcription initiation at the RNA polymerase II promoter, and formation of the translation preinitiation complex. While a few terms relate to DNA repair, hypoxia response, or innate immune signaling, the dominant theme ties to RNA processing and transcriptional/translational regulation.","confidence":"Medium","size":12,"edges":7,"triangles":0,"max_degree":3,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1901407","count":5},{"id":"GO:0031047","count":5},{"id":"GO:0048026","count":5},{"id":"GO:0006367","count":4},{"id":"GO:0001731","count":4}]},{"hash":"1025665897533230175","title":"Peptide and collagen catabolism in tissue remodeling","description":"Top GO terms highlight catabolic proteolysis of bradykinin, neuropeptides, and collagen, plus bone remodeling processes (bone resorption, intramembranous ossification) and development-related terms (lung branching morphogenesis, decidualization). The common theme is proteolytic remodeling of extracellular matrix and peptide signaling across tissues, supporting a label focused on peptide/ECM catabolism in tissue remodeling.","confidence":"Medium","size":12,"edges":16,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0010815","count":5},{"id":"GO:0051603","count":3},{"id":"GO:0060448","count":3},{"id":"GO:0010813","count":3},{"id":"GO:0045453","count":3}]},{"hash":"334960967933199209","title":"Developmental transcription regulation and chromatin assembly","description":"The set includes terms for transcription (DNA-templated transcription, transcription factor activity regulation), chromatin organization (nucleosome assembly), and developmental processes in neural and cardiac tissues (hippocampus and cerebellar cortex development, heart development), suggesting proteins that regulate gene expression during development via chromatin-based mechanisms. Some terms are broader or less connected (e.g., viral replication regulation, nitric oxide response), but the core signal is transcription/chromatin control in development.","confidence":"Medium","size":12,"edges":2,"triangles":0,"max_degree":2,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0045071","count":3},{"id":"GO:0033138","count":3},{"id":"GO:0071732","count":3},{"id":"GO:0021766","count":3},{"id":"GO:0032298","count":3}]},{"hash":"1392169912983716224","title":"Inflammatory and xenobiotic stress signaling","description":"This cluster centers on immune/inflammatory responses (inflammatory response, LPS, IL-8 production), responses to xenobiotics, DNA damage response, and signaling regulation (ERK cascade, GTPase activity), suggesting a cohesive theme of stress- and immune-signaling processes. The presence of a couple of developmental terms appears incidental, not defining the core function.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0042493","count":2},{"id":"GO:0006954","count":2},{"id":"GO:0006974","count":2},{"id":"GO:0048749","count":2},{"id":"GO:0032496","count":2}]},{"hash":"519931631989352112","title":"Ribosome biogenesis and translation","description":"The cluster is dominated by GO terms for translation (GO:0006412), ribosome biogenesis (GO:0042254), and maturation of rRNA (GO:0000463/0462/0466), pointing to components of ribosome assembly and protein synthesis. While there are a few viral-related terms (e.g., virion assembly, membrane fusion) present, the core signal centers on ribosome-related processes and transcriptional activity linked to gene expression. Therefore, the label reflects ribosome biogenesis and translation rather than viral functions.","confidence":"High","size":12,"edges":33,"triangles":33,"max_degree":8,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0006412","count":5},{"id":"GO:0042254","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0000463","count":3},{"id":"GO:0000462","count":3}]},{"hash":"1910251323501857844","title":"Neural vesicle regulation and nigral development","description":"The cluster prominently features GO terms tied to synaptic vesicle endocytosis/exocytosis and excitatory signaling, along with substantia nigra development, suggesting a focus on neural signaling and brain development. Other terms such as mitotic cell cycle, ossification, xenobiotic response, and protein sumoylation regulation appear less directly connected to this theme, indicating some functional noise but not outweighing the neural-centric signals. ","confidence":"Low","size":12,"edges":7,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0021762","count":3},{"id":"GO:0060079","count":3},{"id":"GO:0000278","count":3}]},{"hash":"2142399052311149497","title":"Protein trafficking and stress response","description":"This cluster centers on proteins involved in post-translational modification and subcellular localization (peptidyl-tyrosine sulfation, mitochondria distribution, photoreceptor outer segment localization) and responses to cellular stress (unfolded protein response), suggesting a theme around protein processing and targeted localization within the cell. While there are some unrelated terms (development, obsolete annotations, innate immunity), the dominant signal ties to how proteins are modified, trafficked, and managed under stress. ","confidence":"Medium","size":12,"edges":15,"triangles":0,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0051301","count":8},{"id":"GO:0006478","count":7},{"id":"GO:0048312","count":7},{"id":"GO:0006986","count":6},{"id":"GO:1903546","count":6}]},{"hash":"1553252505349312806","title":"Mitochondrial Translation and Energy Metabolism","description":"The dominant GO term is translation, paired with mitochondrial electron transport, which together suggest involvement in mitochondrial gene expression and energy production. Supporting terms like iron-sulfur cluster assembly and chaperone-mediated folding point to mitochondrial protein maturation and quality control, while other terms (cell cycle, GTPase activity, heat response, cobalamin biosynthesis) appear as secondary or broader cellular processes. Overall, the cluster seems centered on mitochondrial translation and metabolism with some ancillary functions.","confidence":"Medium","size":12,"edges":66,"triangles":220,"max_degree":11,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":6},{"id":"GO:0006120","count":2},{"id":"GO:0006541","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0018108","count":1}]},{"hash":"681219991514588196","title":"Amino acid metabolism and protein turnover","description":"Based on the Top Terms, the cluster shows links to amino acid biosynthesis (lysine, arginine) and broader metabolic processes (purine metabolism, ureide/ allantoin pathways) as well as peptide catabolic processes and proteolysis, with a note of obsolete terms suggesting legacy annotations. The lack of edges indicates these proteins may not participate in a single cohesive pathway but collectively touch on amino acid metabolism and protein processing. This makes \"Amino acid metabolism and protein turnover\" a concise, representative label.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0015031","count":2},{"id":"GO:0043171","count":1},{"id":"GO:0009089","count":1},{"id":"GO:0019877","count":1},{"id":"GO:0006508","count":1}]},{"hash":"2029938737475348161","title":"Unknown","description":"This cluster shows a highly varied set of GO terms, spanning RNA processing (SSU-rRNA maturation and RNA guanine-N7 methylation), GPCR signaling, cellular hypoxia response, and developmental processes in reproductive tissues and skeletal system. With no edges or interactions among the proteins, there is no clear, cohesive shared function that ties all members together. Therefore, a single concise functional label cannot be reliably assigned beyond Unknown.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000462","count":2},{"id":"GO:0072520","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0036265","count":2},{"id":"GO:0071456","count":2}]},{"hash":"1979548531446850619","title":"Secondary metabolite and lipid metabolism","description":"The top GO terms cluster around biosynthesis of secondary metabolites (alkaloids, antibiotics, PHB) and lipid-related processes (triglyceride catabolism, phospholipid dephosphorylation), with additional redox and nitrogen utilization terms that fit within broad metabolic functioning. This suggests a cohesive theme of metabolism of small molecules and lipids, rather than a single, narrow pathway.","confidence":"Medium","size":12,"edges":11,"triangles":1,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0009820","count":2},{"id":"GO:0019433","count":2},{"id":"GO:0046839","count":2},{"id":"GO:0042619","count":2},{"id":"GO:0009086","count":2}]},{"hash":"557049713901801639","title":"Developmental Transcriptional Regulation","description":"The cluster centers on transcriptional control, with GO terms for DNA-templated transcription and negative regulation of transcription by RNA Pol II, and extends across diverse developmental pathways such as endocrine pancreas development, skeletal muscle and myotube differentiation, osteoblast differentiation, and oligodendrocyte fate specification, suggesting a set of factors that modulate differentiation programs in multiple lineages rather than a single tissue-specific function.","confidence":"Medium","size":12,"edges":61,"triangles":177,"max_degree":11,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0006351","count":8},{"id":"GO:0031018","count":7},{"id":"GO:0060766","count":7},{"id":"GO:0045668","count":7},{"id":"GO:0000122","count":5}]},{"hash":"730637568531918853","title":"Unknown","description":"GO terms span diverse developmental and signaling processes (salivary gland branching, lens differentiation, axon guidance, synapse organization, erythropoietin signaling, cytokine regulation, STAT phosphorylation) with no single, unifying theme. With no known interactions (Edges 0), there isn't a coherent function to label, so Unknown is most appropriate.","confidence":"","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":2},{"id":"GO:0035584","count":2},{"id":"GO:0038162","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0071639","count":2}]},{"hash":"201475735880377453","title":"Diverse secondary metabolite biosynthesis","description":"The GO terms show multiple biosynthetic pathways for natural products (antibiotics, daunorubicin, flavonols, lignin) and NADPH regeneration, suggesting a cluster of proteins involved in producing diverse secondary metabolites with supporting redox chemistry. A few methylation terms exist, but the main signal is secondary metabolite biosynthesis rather than a single shared function.","confidence":"Medium","size":12,"edges":14,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0017000","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0006740","count":2},{"id":"GO:0035573","count":1},{"id":"GO:0018012","count":1}]},{"hash":"2242300571088490013","title":"Pain and temperature sensing signaling","description":"Most terms cluster around nociception and thermosensation (sensory perception of pain, cellular response to temperature stimulus, diet-induced thermogenesis), with supporting neuromodulatory and inflammatory signaling (dopamine receptor signaling, prostaglandin response) and neuronal excitability (regulation of membrane potential). While a few terms point to broader endocrine or glial processes, the dominant theme is neural signaling in response to heat/pain-related stimuli.","confidence":"Medium","size":12,"edges":14,"triangles":4,"max_degree":7,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":10},{"id":"GO:0002024","count":10},{"id":"GO:0071502","count":10},{"id":"GO:0018298","count":8},{"id":"GO:0042391","count":8}]},{"hash":"145985346404243024","title":"Early Development, Wnt Regulation, and Proteostasis","description":"This cluster aggregates signals related to embryogenesis (primitive streak formation, blastocyst development) and developmental pathways (regulation of Wnt signaling), coupled with cell-cycle processes (cell division, cell cycle) and proteostasis components (proteasome regulatory particle assembly, aggresome assembly). The shared GO themes point to a group of proteins involved in early development and growth control, with supporting roles in protein homeostasis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0048935","count":3},{"id":"GO:0090009","count":3},{"id":"GO:0030111","count":3},{"id":"GO:0051301","count":2}]},{"hash":"2222783233806225376","title":"Neuronal Development and Synaptic Signaling","description":"Reasoning: The top terms converge on nervous system development, regulation of synaptic vesicle exocytosis, and multiple signaling pathways (Robo, Hedgehog/Smoothened, ERK, PI3K, Rho). This indicates a cluster of proteins involved in neuronal development and synaptic regulation, with additional developmental processes (kidney, macrophage differentiation) as broader context.","confidence":"Medium","size":12,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000300","count":3},{"id":"GO:0035023","count":2},{"id":"GO:0035385","count":2},{"id":"GO:0070374","count":2},{"id":"GO:0043552","count":2}]},{"hash":"184547593284509142","title":"Synaptic transmission and circadian locomotor behavior","description":"The cluster centers on neuronal signaling: ion transport via K+/Na+ channels and Ca2+ import, plus GABA and serotonin signaling, excitatory postsynaptic potentials, and behavioral responses such as startle and locomotion; the presence of a circadian sleep/wake regulation term ties these signals to circadian-modulated behavior, suggesting a cohesive theme of synaptic communication linked to movement and timing.","confidence":"High","size":12,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":10},{"id":"GO:0045188","count":9},{"id":"GO:0098703","count":9},{"id":"GO:0001964","count":9},{"id":"GO:0035725","count":9}]},{"hash":"2269109352150024246","title":"Developmental Morphogenesis and ECM Remodeling","description":"These proteins show GO terms spanning embryonic development and tissue patterning (neuronal regeneration, placental and endocrine development, heart EMT, left-right patterning, cartilage morphogenesis) plus extracellular matrix remodeling (hyaluronan metabolism, negative regulation of ECM assembly). Although there are no observed interactions here, the common theme is developmental morphogenesis coupled with ECM dynamics.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031104","count":2},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1},{"id":"GO:0003323","count":1}]},{"hash":"795384567640255768","title":"Antiviral innate immune signaling and antigen presentation","description":"The cluster\u2019s terms cluster around innate immune responses, type I interferon signaling, dsRNA sensing, and antigen processing via MHC class II, with notes on virus defense regulation and symbiont-mediated immune modulation, suggesting an antiviral/immune-sensing core. Some terms (cilium assembly, GPCR signaling regulation, cell division, polyubiquitination) are less central, but the dominant theme is innate antiviral immune signaling.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060271","count":1},{"id":"GO:0008277","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0071357","count":1}]},{"hash":"1789925149450697622","title":"Oxidative/ER Stress Response","description":"This cluster centers on oxidative and ER stress-related processes, with repeated GO terms for hydrogen peroxide catabolic process, cell redox homeostasis, and the ER stress response. While there are additional signals related to transcriptional regulation and nucleotide biosynthesis, the dominant pattern points to managing oxidative stress and unfolded protein response. Therefore, the label Oxidative/ER Stress Response is a concise, representative description of the cluster\u2019s function.","confidence":"Medium","size":12,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006958","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0042744","count":1},{"id":"GO:0072358","count":1}]},{"hash":"1333985054335431208","title":"Coagulation, fibrinolysis, and ECM remodeling","description":"This cluster's top GO terms cluster around proteolytic processes that remodel tissue and regulate coagulation: blood coagulation, fibrinolysis, plasminogen activation, extracellular matrix disassembly, and tissue remodeling. Complement activation via the lectin pathway also ties into immune-modulated matrix turnover. While a couple terms (midbrain development, transcriptional regulation) appear as noise, the predominant signal is protease-driven remodeling of extracellular matrix and hemostasis.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":6},{"id":"GO:0030901","count":6},{"id":"GO:1902947","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0042730","count":5}]},{"hash":"1066175176584511508","title":"Vascular morphogenesis and adhesion regulators","description":"This cluster is dominated by GO terms related to blood vessel development and regulation (angiogenesis, pulmonary artery morphogenesis, smooth muscle contraction) and cell-matrix adhesion, suggesting a core function in vascular morphogenesis and signaling. Some terms (synaptic gephyrin clustering, marginal zone B cell differentiation, grooming behavior) point to neural/immune roles or noise, but the vascular-related terms appear most representative of the cluster.","confidence":"Medium","size":12,"edges":1,"triangles":0,"max_degree":1,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0033138","count":4},{"id":"GO:0007160","count":4},{"id":"GO:0045987","count":4},{"id":"GO:0016525","count":4}]},{"hash":"687492741645155804","title":"RNA Splicing and Transcription Regulation","description":"The cluster shows a coherent core around nuclear RNA processing and transcription control, with terms for RNA splicing, spliceosome activity, and nuclear mRNA surveillance, as well as regulation of transcription. A few terms touch on trafficking and neuronal signaling (receptor recycling, endosome size, glutamatergic transmission), which may reflect ancillary connections to synaptic regulation, but the dominant theme is RNA processing.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035023","count":1},{"id":"GO:0051036","count":1},{"id":"GO:0060316","count":1},{"id":"GO:0001881","count":1},{"id":"GO:0035249","count":1}]},{"hash":"1418242144422926371","title":"Neuronal differentiation and synapse assembly","description":"The top GO terms cluster around neural development and synaptic organization, including pyramidal neuron differentiation, axon guidance, cell adhesion, and positive regulation of synapse assembly, with some heart/organ development terms likely reflecting broader developmental roles. This suggests the cluster represents proteins involved in neuronal differentiation and synaptic formation rather than a single signaling pathway.","confidence":"Medium","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000187","count":3},{"id":"GO:0045163","count":2},{"id":"GO:0021859","count":2},{"id":"GO:0007155","count":2},{"id":"GO:0001759","count":2}]},{"hash":"599063339417503188","title":"GPCR-mediated cardiovascular and neuroendocrine signaling","description":"These proteins are enriched for GPCR signaling, including adenylate cyclase-activating pathways and dopamine receptor signaling, along with terms tied to cardiovascular regulation (positive regulation of blood pressure, renin secretion). Additional terms point to neuroendocrine/neural interactions (astrocyte chemotaxis, response to peptide, prostaglandin response). The electron transport chain term is less central but may reflect cellular energy support for signaling. Overall, the cluster seems driven by GPCR-mediated signaling with cardiovascular and neuroendocrine implications.","confidence":"High","size":12,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0010579","count":8},{"id":"GO:0022900","count":8},{"id":"GO:0045777","count":8},{"id":"GO:0035025","count":7},{"id":"GO:0007191","count":6}]},{"hash":"75103413868684516","title":"Ribosome Biogenesis and Translation","description":"This cluster is dominated by GO terms related to the protein synthesis machinery: translation, cytoplasmic translation, translational initiation, ribosome biogenesis, and maturation of SSU-rRNA, with additional terms on translation fidelity and a minor antibiotic-response signal. An outlier osteoblast differentiation term is present but does not override the core theme of ribosome assembly and function.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":10},{"id":"GO:0046677","count":5},{"id":"GO:0000462","count":3},{"id":"GO:0042254","count":2},{"id":"GO:0006413","count":2}]},{"hash":"607313412302919009","title":"Ubiquitin-Proteasome Regulation in Cell Cycle and Development","description":"This cluster is enriched for ubiquitin-related processes (K11-linked ubiquitination; ubiquitin-dependent protein catabolic process; ERAD pathway) and cell cycle control (deactivation of the mitotic spindle assembly checkpoint, meiotic cell cycle regulation), plus several development-related terms (lens fiber differentiation, skeletal system development, dendrite development). The convergence on ubiquitin-mediated protein turnover across both cell cycle and developmental contexts suggests a coherent theme: proteins regulated by ubiquitination are controlling division and tissue development in these members. Intraciliary retrograde transport may reflect ciliary dynamics linked to ubiquitin signaling as well. Overall, the dominant thread is ubiquitin-dependent regulation of protein turnover that ties cell cycle control to development.","confidence":"High","size":11,"edges":31,"triangles":37,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1902426","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0051441","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0001501","count":2}]},{"hash":"1204845292496544658","title":"Mitochondrial Translation and Energy Metabolism","description":"The cluster shows strong representation of mitochondrial protein synthesis (translation, mitochondrial translation initiation, ribosome assembly) alongside core energy pathways (ETC, TCA cycle, acetyl-CoA and succinyl-CoA biosynthesis), with a hint of mitochondrial calcium import. While a couple of terms relate to ncRNA silencing/splicing, the dominant pattern points to mitochondrial gene expression and energy production.","confidence":"High","size":11,"edges":55,"triangles":165,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0042255","count":2},{"id":"GO:0006122","count":2},{"id":"GO:0006412","count":2}]},{"hash":"2282161651197787623","title":"Genome maintenance and ER-Golgi trafficking","description":"This cluster mixes DNA replication/repair signals (DNA replication, UV-damage excision repair) with secretory pathway and quality-control terms (ER to Golgi transport, intralumenal vesicle formation, Golgi protein retention, ubiquitin-dependent ERAD). It also includes cell division and cytoskeletal dynamics (microtubule severing) and stress responses, suggesting two modules\u2014genome maintenance and vesicle trafficking/quality control\u2014within the same set of proteins rather than a single unified function.","confidence":"Medium","size":11,"edges":35,"triangles":60,"max_degree":10,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":5},{"id":"GO:0070914","count":5},{"id":"GO:0030433","count":4},{"id":"GO:0070676","count":4},{"id":"GO:0034599","count":4}]},{"hash":"949588883851216478","title":"Neuronal Synaptic Plasticity and Calcium Signaling","description":"Dominated by terms for synaptic plasticity and calcium signaling (regulation of long-term potentiation, regulation of postsynaptic cytosolic calcium, neuronal synaptic plasticity), with some peripheral notes on glucocorticoid response and muscle contraction; overall, the cluster centers on neuronal signaling and plasticity mechanisms.","confidence":"High","size":11,"edges":23,"triangles":23,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:1903799","count":5},{"id":"GO:1900271","count":5},{"id":"GO:2001015","count":5},{"id":"GO:0099566","count":5},{"id":"GO:0051384","count":5}]},{"hash":"1927233881448671276","title":"Ion and Small-Molecule Membrane Transporters","description":"The top GO terms point to transmembrane transport of a range of ions (K+, Na+, nitrate/nitrite, phosphate) and small molecules (vitamins, galactose, 4-hydroxyphenylacetate), with one metabolic process term. This pattern strongly indicates a cluster of proteins functioning as membrane transporters rather than a single pathway or enzyme, hence a transporter-centric label.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0015707","count":4},{"id":"GO:0035435","count":4},{"id":"GO:0035725","count":4},{"id":"GO:0035461","count":4}]},{"hash":"1619011176370586487","title":"Antiviral innate immunity and interferon response","description":"This cluster is dominated by GO terms tied to innate antiviral defense and interferon signaling, including cellular responses to interferon-beta, interferon-beta production, defense/response to virus, and dsRNA sensing. The presence of DNA-templated transcription suggests downstream transcriptional programs activated during antiviral responses, making this a cohesive antiviral/IFN functional module.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0002230","count":1},{"id":"GO:0033160","count":1},{"id":"GO:0045087","count":1},{"id":"GO:0042993","count":1}]},{"hash":"1037190731769040241","title":"Neural development and ectoderm formation","description":"The dominant GO terms point to neural lineage and ectoderm-derived tissues (midbrain development, locus ceruleus development, olfactory bulb interneuron differentiation, spinal cord oligodendrocyte fate specification, ectoderm formation). There are also related developmental processes (neuromuscular activity, hepatoblast differentiation) and ECM remodeling, suggesting a broader but developmentally focused theme. Given the emphasis on neural/ectodermal development with some supporting regulatory and remodeling terms, this label captures the cluster\u2019s core function without overfitting to a single tissue. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0030901","count":3},{"id":"GO:0022617","count":2},{"id":"GO:0042663","count":2},{"id":"GO:0021889","count":2}]},{"hash":"187458207652037047","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0000466","count":4},{"id":"GO:0000463","count":4},{"id":"GO:0042766","count":3},{"id":"GO:0000462","count":3},{"id":"GO:0006260","count":3}]},{"hash":"422700087616237580","title":"Microtubule dynamics and neuronal projection maintenance","description":"The cluster is strongly enriched for microtubule-related processes (plus/minus-end transport, polarity establishment, depolymerization) and neuron projection maintenance, with supporting hints from cytoskeletal organization in cerebellar structures, suggesting a cohesive role in microtubule-driven neuronal architecture.","confidence":"High","size":11,"edges":49,"triangles":120,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:1990942","count":10},{"id":"GO:0045218","count":10},{"id":"GO:0031534","count":10},{"id":"GO:1990535","count":10},{"id":"GO:0021685","count":10}]},{"hash":"267890519785354106","title":"Hypoxia and innate immune stress response","description":"Most represented GO terms cluster around stress and antiviral defense: response to hypoxia, innate immune response, and defense response to virus (each with 6 annotations). This suggests proteins in this group participate in cellular stress signaling and antiviral defense. While terms related to DNA replication and mitosis are present (e.g., cell division, DNA replication steps) they are less central to the main theme here and may reflect background housekeeping roles. Overall, the dominant signal points to a stress- and immune-related function cluster.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0001666","count":6},{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0045842","count":6},{"id":"GO:0006268","count":5}]},{"hash":"463573580440589451","title":"Unknown","description":"The GO terms span very diverse processes (atrial septum and ureter development, photoreceptor localization, innate immune response, unfolded protein response, ubiquitination, metabolism, epigenetic regulation, and even plant hormone signaling). There is no single cohesive function or pathway that unifies these terms for this protein cluster, so a meaningful, specific label cannot be assigned.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0003283","count":11},{"id":"GO:0090526","count":11},{"id":"GO:0006986","count":10},{"id":"GO:1903546","count":10},{"id":"GO:0009938","count":10}]},{"hash":"2085469725188894016","title":"Lipid and steroid metabolism","description":"The cluster is dominated by lipid and steroid-related biosynthetic and catabolic processes (retinol metabolism, very long-chain fatty acids, glucocorticoid/steroid metabolism), with related small-molecule pathways (tetrahydrobiopterin, PHB) and a few peripheral terms (antibiotic biosynthesis). This points to a cohesive theme of lipid/steroid metabolism, with occasional unrelated biosynthetic activities appearing as outliers. ","confidence":"Medium","size":11,"edges":10,"triangles":6,"max_degree":4,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0042572","count":6},{"id":"GO:0006704","count":6},{"id":"GO:0046677","count":6},{"id":"GO:0042761","count":6},{"id":"GO:0042208","count":6}]},{"hash":"478162781154758935","title":"Unknown","description":"Unknown","confidence":"","size":11,"edges":24,"triangles":28,"max_degree":8,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0009103","count":6},{"id":"GO:0016311","count":6},{"id":"GO:0005975","count":6},{"id":"GO:0030836","count":5},{"id":"GO:0032361","count":5}]},{"hash":"452181832976462788","title":"Diverse Metabolite Biosynthesis","description":"The proteins cluster around many distinct biosynthetic processes (antibiotic, retinol, glucocorticoid, estrogen, melanin, very long-chain fatty acids, PHB, BH4), suggesting a shared role in producing a variety of metabolites rather than a single pathway. There is one antibiotic response term and an obsolete oxidation-reduction term, but the dominant signal is biosynthesis of diverse biomolecules.","confidence":"High","size":11,"edges":41,"triangles":70,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0017000","count":5},{"id":"GO:0055114","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0006704","count":4},{"id":"GO:0046677","count":4}]},{"hash":"93962151417330028","title":"Actin Cytoskeleton Remodeling and Immune Cell Polarity","description":"The cluster is dominated by GO terms for actin cytoskeleton organization, actin crosslink formation, microspike assembly, and cortical patch localization, all signaling coordinated actin remodeling and structural organization. Additional terms on cell adhesion and cell shape polarity maintenance indicate roles in cell polarity and adhesion, often coordinated by Rho signaling. The presence of innate immune response and interleukin-2 production suggests this remodeling occurs within immune cells, linking cytoskeletal dynamics to immune cell activation and movement.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0051661","count":4},{"id":"GO:0035023","count":4},{"id":"GO:1900042","count":4},{"id":"GO:0030035","count":4}]},{"hash":"150153667663001276","title":"Steroid hormone signaling and male development","description":"The top GO terms are dominated by steroid hormone receptor complex assembly, prostate gland development, and male sex differentiation, indicating a theme of androgen signaling and male development. Some outlier terms (interferon response, unfolded protein response, and photoreceptor localization) appear but do not define the cluster.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006463","count":6},{"id":"GO:0030850","count":6},{"id":"GO:0046661","count":6},{"id":"GO:0071357","count":6},{"id":"GO:0006986","count":5}]},{"hash":"1678627221267302055","title":"Unknown","description":"The GO terms span metabolism, protein modification and turnover, trafficking, RNA export, cytoskeleton regulation, and multiple innate immune signaling pathways, with no single cohesive function linking them. This suggests no clear, interpretable label for the cluster.","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006631","count":1},{"id":"GO:0002084","count":1},{"id":"GO:0042997","count":1},{"id":"GO:0006409","count":1},{"id":"GO:1902745","count":1}]},{"hash":"1501306602557009897","title":"Neural signaling and synaptic regulation","description":"This cluster shows a convergence on neuronal signaling and synaptic processes: regulation of opioid receptor signaling, serotonin uptake, synaptic vesicle priming, and grooming behavior, plus a response to prostaglandin E, suggesting roles in neural signaling and behavioral modulation. Some outliers (DNA transposition, endothelial proliferation, ceramide transport) appear, but the core is neural communication and synaptic function.","confidence":"Medium","size":11,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0046329","count":2},{"id":"GO:0001935","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0051612","count":1},{"id":"GO:0043113","count":1}]},{"hash":"1707292340246569206","title":"Neural and Immune Signaling Pathways","description":"The cluster is enriched for brain and nervous system development and synaptic vesicle trafficking (exocytosis and endocytosis), plus axon guidance (ROBO signaling). It also includes immune signaling terms (T cell receptor signaling, mast cell chemotaxis), suggesting a broader theme of signaling processes active in both neural development and immune responses. This coherence supports labeling as neural-immune signaling, rather than a single isolated pathway.","confidence":"Medium","size":11,"edges":46,"triangles":102,"max_degree":10,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0031384","count":7},{"id":"GO:2000300","count":7},{"id":"GO:0010796","count":7},{"id":"GO:0007420","count":6},{"id":"GO:0035385","count":6}]},{"hash":"474467364801657383","title":"GPCR signaling in heart, vision, and thermogenesis","description":"The cluster is dominated by GPCR-related pathways, including dopamine and adrenergic receptor signaling, which link to phototransduction (vision), sensory perception, temperature and diet-induced thermogenesis, and heart development. Downstream processes such as GTPase activity regulation, membrane potential, and phosphatidylinositol biosynthesis converge on GPCR-driven signal transduction, supporting a cohesive functional theme.","confidence":"High","size":11,"edges":52,"triangles":141,"max_degree":10,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":7},{"id":"GO:0043547","count":7},{"id":"GO:0042391","count":7},{"id":"GO:0071880","count":7},{"id":"GO:0007603","count":7}]},{"hash":"62847317293757690","title":"Immune-vascular development and regulation","description":"GO terms center on immune cell differentiation (NK and T cells) and vascular/endothelial regulation (endothelial apoptosis, coagulation), with additional developmental cues (skeletal morphogenesis, fertilization). This pattern suggests a role in coordinating immune responses with vascular and developmental remodeling, though some terms are less directly connected. Confidence: Medium","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007338","count":3},{"id":"GO:0001666","count":2},{"id":"GO:0032825","count":2},{"id":"GO:2000352","count":2},{"id":"GO:0048705","count":2}]},{"hash":"2213379647711798755","title":"Ubiquitin-Dependent Innate Immune Signaling","description":"The cluster centers on innate immune and antiviral defense, with multiple ubiquitin-related processes (polyubiquitination, ubiquitin-dependent degradation, and non-degradative K63-linked ubiquitination) suggesting a module where ubiquitin signaling modulates antiviral responses, potentially involving NF-kappaB pathways. Ancillary terms like NO regulation and microtubule localization may reflect downstream or contextual aspects of immune signaling.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0045087","count":6},{"id":"GO:0051607","count":6},{"id":"GO:0030433","count":6},{"id":"GO:0051092","count":6},{"id":"GO:0097039","count":5}]},{"hash":"1514391932150119820","title":"Inflammatory signaling and dendritic cell activation","description":"This cluster is dominated by GO terms related to inflammation, type 2 immune responses, and the regulation of dendritic cell antigen processing and presentation, plus TNF production and NF-kappaB\u2013related signaling. While there are a few secondary terms (Wnt signaling, manganese response, neuronal migration), the strongest shared function appears to be immune activation and DC-mediated antigen presentation.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0002830","count":4},{"id":"GO:0002606","count":4},{"id":"GO:0090394","count":4},{"id":"GO:1904887","count":4},{"id":"GO:1902499","count":4}]},{"hash":"487688065645718683","title":"Large subunit ribosome biogenesis and export","description":"The protein set shows strong enrichment for large ribosomal subunit (LSU) biogenesis terms, including LSU rRNA maturation (5.8S and LSU), LSU preribosome assembly, and LSU export from the nucleus, indicating a shared role in assembling and exporting the large ribosomal subunit. Other GO terms are sporadic and do not define the core function of the cluster.","confidence":"High","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0097011","count":2},{"id":"GO:0000463","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0000027","count":1},{"id":"GO:1902626","count":1}]},{"hash":"2042634550727075309","title":"Tissue development and differentiation","description":"The terms point to developmental programs and tissue remodeling across several organs (reproductive, lymphatic, mammary, muscle) with related signaling processes; while there are metabolic and immune-stress terms, the unifying theme is lineage specification and organogenesis/differentiation.","confidence":"Medium","size":11,"edges":17,"triangles":7,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0035902","count":9},{"id":"GO:0036367","count":7},{"id":"GO:1903799","count":7},{"id":"GO:0043415","count":7},{"id":"GO:0060599","count":7}]},{"hash":"1331802457539043979","title":"Circadian and Sensory Neuronal Signaling","description":"This cluster centers on neuronal excitability and sensory processing, highlighted by circadian sleep regulation, calcium and potassium ion transport, action potential, startle response, mechanical sound detection, and serotonin signaling. While a couple of terms seem unrelated (ovulation rhythm, cartilage morphogenesis), the dominant theme is neural signaling tied to circadian and sensory functions.","confidence":"High","size":11,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0045188","count":10},{"id":"GO:0098703","count":10},{"id":"GO:0001964","count":10},{"id":"GO:0071805","count":9},{"id":"GO:0050910","count":9}]},{"hash":"1292423263259409741","title":"Unknown","description":"The Top Terms show a wide mix of processes (oxidation-reduction, detoxification, lipid metabolism, several differentiation pathways, coagulation, and miscellaneous development terms) with no clear, shared function linking the proteins. There are no edges to suggest a cohesive interaction network, making it impossible to infer a unifying theme. Therefore, Unknown with None. ","confidence":"","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0045445","count":2},{"id":"GO:0048714","count":2},{"id":"GO:0090370","count":2}]},{"hash":"742399419872022208","title":"Immune and stress signaling","description":"The top GO terms point to inflammatory and signaling pathways (TNF signaling, chemokine production, integrin signaling, GPCR-related signaling) together with environmental responses (cold, vitamin D) and regulatory processes like ubiquitination and transcription. This suggests a theme of signaling-driven regulation in immune and stress responses, rather than a single, cohesive molecular function.","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":4},{"id":"GO:0009409","count":4},{"id":"GO:0007205","count":4},{"id":"GO:0016567","count":4},{"id":"GO:0018032","count":4}]},{"hash":"2161671831076070610","title":"Notch-regulated embryonic neurodevelopment","description":"The top terms cluster around Notch signaling regulation and developmental processes\u2014embryo development, left-right axis specification, and ventral spinal cord interneuron fate\u2014suggesting a theme of developmental signaling governed by Notch. Coagulation and redox terms are present but do not define the main function of the cluster. ","confidence":"Medium","size":11,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045746","count":7},{"id":"GO:0007596","count":7},{"id":"GO:0051919","count":7},{"id":"GO:0031639","count":7},{"id":"GO:0055114","count":7}]},{"hash":"876538533430811960","title":"Neurodevelopment and tissue differentiation","description":"The GO terms cluster around developmental differentiation across neural regions (olfactory bulb interneuron differentiation, locus ceruleus development, spinal cord oligodendrocyte fate specification, hypothalamus differentiation) and other tissues (ectoderm/endoderm formation, hepatoblast differentiation, digestive tract development), with additional neuromuscular and behavioral terms. This suggests the proteins participate in broad developmental programs, especially neural development, rather than a single specific pathway. ","confidence":"Medium","size":11,"edges":15,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0042663","count":5},{"id":"GO:0021889","count":5},{"id":"GO:0050905","count":5},{"id":"GO:0021703","count":5},{"id":"GO:0001705","count":5}]},{"hash":"880346915318937843","title":"Mitochondrial transport and membrane dynamics","description":"The cluster is dominated by GO terms about transport of ions and metabolites across mitochondrial membranes (phosphate, manganese, ATP, citrate, CoA), together with mitochondrial membrane potential regulation and mitochondrial fission, plus apoptotic mitochondrial changes and a link to insulin secretion in response to glucose. This points to a cohesive theme of mitochondrial transport and dynamic processes that support cellular energy metabolism.","confidence":"High","size":11,"edges":9,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035435","count":5},{"id":"GO:0008637","count":5},{"id":"GO:0006828","count":5},{"id":"GO:1990544","count":5},{"id":"GO:0006843","count":5}]},{"hash":"2043958876813594897","title":"Neural development and synaptic signaling","description":"The top GO terms cluster around neural development and synaptic function\u2014retina layer formation, axon guidance, regulation of synaptic vesicle endocytosis, long-term potentiation, and postsynaptic calcium control\u2014indicating a theme of neural development and synaptic signaling, with a few terms related to muscle or general stress responses likely peripheral noise.","confidence":"High","size":11,"edges":10,"triangles":0,"max_degree":10,"top_function":null,"top_go_terms":[{"id":"GO:0010842","count":2},{"id":"GO:1900242","count":2},{"id":"GO:0042403","count":2},{"id":"GO:0071679","count":2},{"id":"GO:1903799","count":1}]},{"hash":"1954326198258419516","title":"Innate Immune Defense and MHC I Regulation","description":"The top GO terms are dominated by innate immune response and defense against pathogens (virus and Gram-positive bacteria), with several terms relating to the MHC class I biosynthetic process. This points to a core function in immune defense and antigen presentation. A few unrelated terms (mitotic spindle assembly, various differentiation terms) are likely incidental annotations and do not change the overall immune-focused signal. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":3},{"id":"GO:0051607","count":2},{"id":"GO:0050830","count":2},{"id":"GO:0090307","count":2},{"id":"GO:0045345","count":2}]},{"hash":"1940162894196840440","title":"Atrial development and conduction signaling","description":"The cluster centers on atrial heart development and electrical signaling, with GO terms like atrial septum development, SA node cell to atrial cardiac muscle cell communication, and atrial cardiac muscle cell action potential, plus membrane localization in cardiomyocytes (T-tubule, plasma membrane). Some neuronal guidance terms appear but are less representative; overall, the theme is atrial development and conduction. ","confidence":"Medium","size":11,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":1},{"id":"GO:0036371","count":1},{"id":"GO:0035156","count":1},{"id":"GO:0086070","count":1},{"id":"GO:0086014","count":1}]},{"hash":"1557053997727984269","title":"Unknown","description":"The GO terms span translation, TGF-beta/SMAD signaling, plant meristem identity, vacuole fusion, nuclear export, photosystem regulation, and even germ-line masculinization, showing no single cohesive function or pathway linking the proteins. The lack of edges and the diverse, sparsely represented terms suggest the annotations do not reflect a unified biological role for this cluster.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":2},{"id":"GO:0035970","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0010074","count":2},{"id":"GO:0030512","count":2}]},{"hash":"1564219067391955889","title":"Developmental Regulation and Stress Responses","description":"Proteins in this cluster touch on developmental processes (neural tube closure, forebrain and skeletal development) and transcriptional regulation (DNA-templated transcription, cell cycle), while also showing stress/defense themes (ER-stress apoptosis, cadmium response, defense against Gram-positive bacteria). The combination suggests a theme around developmental gene regulation coupled with cellular stress responses.","confidence":"Medium","size":10,"edges":28,"triangles":41,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0006351","count":4},{"id":"GO:0050830","count":4},{"id":"GO:0001403","count":4},{"id":"GO:0070059","count":4},{"id":"GO:0001843","count":4}]},{"hash":"2151554933643992102","title":"Unknown","description":"The cluster lists both RNA processing/splicing terms and viral/symbiont interaction terms, plus a developmental term, yielding a highly mixed functional set without a single dominant theme. As a result, a precise, representative label cannot be assigned.","confidence":"","size":10,"edges":8,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":1},{"id":"GO:0006396","count":1},{"id":"GO:0060325","count":1},{"id":"GO:0019076","count":1},{"id":"GO:0000398","count":1}]},{"hash":"736782753339770466","title":"Membrane receptor signaling and adhesion","description":"These proteins cluster around plasma membrane\u2013associated functions: activation of transmembrane receptor tyrosine kinases, cell-surface signaling (pattern recognition receptor signaling, glutamatergic synaptic transmission), and protein localization to the cell surface, as well as cell\u2013matrix adhesion. The mix of lipid/metabolic and angiogenesis terms is peripheral to the core membrane signaling theme, supporting a label focused on surface-mediated signaling and adhesion.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042730","count":3},{"id":"GO:0051968","count":3},{"id":"GO:0051321","count":2},{"id":"GO:0051005","count":2},{"id":"GO:0002752","count":2}]},{"hash":"1422481251297372667","title":"Neural development and synapse assembly","description":"These proteins show a strong association with nervous system development and synapse formation, including corpus callosum development, nervous system development, and positive regulation of synapse assembly. While there are additional terms related to immune signaling and other processes, the neural development theme is the most prominent in the top GO terms, justifying a label focused on neural development and synapse assembly.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0022038","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0071372","count":4},{"id":"GO:0050852","count":4},{"id":"GO:0007399","count":4}]},{"hash":"2272257913009570945","title":"Unknown","description":"Unknown","confidence":"","size":10,"edges":14,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006469","count":3},{"id":"GO:0016525","count":2},{"id":"GO:0043129","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0030433","count":2}]},{"hash":"489964276960087856","title":"Centromeric and heterochromatin assembly during DNA replication","description":"These proteins show strong signals for CENP-A containing chromatin assembly and heterochromatin formation (including subtelomeric and mating-type locus silencing), as well as pre-replicative complex assembly and DNA replication. This points to a cohesive role in organizing and propagating chromatin states during the cell cycle, especially centromeric and heterochromatin regions during replication. ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0030466","count":5},{"id":"GO:0007049","count":4},{"id":"GO:0061641","count":3},{"id":"GO:0006267","count":3},{"id":"GO:0007292","count":3}]},{"hash":"774969743812286249","title":"Ribosome biogenesis and cell cycle","description":"The cluster is dominated by GO terms tied to ribosome production and export (ribosomal large subunit export from nucleus, ribosome biogenesis) along with cell cycle and cell division, suggesting a coherent theme around ribosome assembly linked to cell proliferation. Supporting terms like tRNA modification and protein targeting to chloroplast fit translation-related roles, while glucose catabolic process adds a metabolic context; a single term about virus-mediated pore formation appears as an outlier. Overall, the core association appears to be ribosome biogenesis with cell cycle progression.","confidence":"High","size":10,"edges":10,"triangles":0,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0000055","count":5},{"id":"GO:0042254","count":5},{"id":"GO:0007049","count":5},{"id":"GO:0006400","count":5},{"id":"GO:0039707","count":5}]},{"hash":"1564812985987990735","title":"Neural axon morphogenesis and ER organization","description":"The terms cluster around neural development, including axon guidance, fasciculation, and branching, as well as radial glia-guided migration and regulation of axon extension, with additional emphasis on ER tubular network maintenance/organization and ER-dependent peroxisome organization, suggesting a theme of neural morphogenesis linked to ER/nuclear architecture. A few apoptosis-related terms appear, but they do not define the group.","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1903378","count":2},{"id":"GO:0060546","count":2},{"id":"GO:0007413","count":1},{"id":"GO:1990809","count":1},{"id":"GO:0021801","count":1}]},{"hash":"1066635806687375163","title":"Cell Cycle and Chromatin Assembly","description":"The top GO terms cluster around cell division, mitotic sister chromatid separation, and DNA replication\u2013dependent chromatin assembly, indicating a central theme of cell cycle progression and chromatin dynamics; other terms may reflect regulatory layers linked to cell cycle control, such as ciliary transport and post-translational modification. ","confidence":"Medium","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":"protein-containing complex assembly","top_go_terms":[{"id":"GO:0051301","count":5},{"id":"GO:0043547","count":4},{"id":"GO:0043550","count":4},{"id":"GO:0051306","count":4},{"id":"GO:1903538","count":4}]},{"hash":"1838046266349804078","title":"Developmental signaling and morphogenesis","description":"The top GO terms point to broad developmental regulation (vagina development, axial mesoderm formation), morphogenesis (dendritic spine morphogenesis, synapse organization, cell-matrix adhesion), and signaling pathways (IL-27 signaling, STAT phosphorylation, TGF-beta regulation). Together, they suggest proteins that coordinate signaling-driven development and structural organization across tissues, including neural connectivity and body plan formation.","confidence":"Medium","size":10,"edges":44,"triangles":112,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:2001202","count":9},{"id":"GO:0050925","count":9},{"id":"GO:0001954","count":9},{"id":"GO:0060068","count":9},{"id":"GO:0050808","count":9}]},{"hash":"1083809784520156441","title":"Neural development and sensory perception","description":"The cluster's top GO terms cluster around nervous system development and sensory function, including Schwann cell development, cerebral cortex layer formation, long-term synaptic potentiation, and visual perception. While there are a few other terms (heart development, glucose response, dsRNA signaling) that reflect broader regulatory contexts, the strongest signal is neural development and sensory processing, justifying a label focused on neural development and sensory function.","confidence":"Medium","size":10,"edges":38,"triangles":73,"max_degree":9,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071333","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0043330","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0007275","count":4}]},{"hash":"1091594099488733096","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"The terms cluster around actin-driven processes: filopodium and lamellipodium assembly, adhesion-dependent spreading, and general cell migration. Rho signaling and insulin receptor pathways link cytoskeletal dynamics to signaling. Although some terms touch on immune signaling and development, the dominant theme is actin remodeling governing cell movement and adhesion.","confidence":"High","size":10,"edges":12,"triangles":2,"max_degree":5,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:1900026","count":7},{"id":"GO:0008286","count":7},{"id":"GO:0035023","count":7},{"id":"GO:0032633","count":7},{"id":"GO:0016477","count":7}]},{"hash":"130176990984218619","title":"Mitochondrial Energy Metabolism and Redox Balance","description":"This cluster is dominated by terms tied to mitochondrial energy production and redox regulation: NADH to ubiquinone electron transport, regulation of membrane potential, and overall redox homeostasis. It also includes dihydrolipoamide\u2013related processes (PDH/OGDH cofactors), 2-oxoglutarate metabolism, and thiamine biosynthesis, all consistent with central carbon metabolism in mitochondria. While a few terms (aging, sperm capacitation) are less central or obsolete, the core theme clearly centers on mitochondrial energy metabolism and redox balance.","confidence":"High","size":10,"edges":41,"triangles":92,"max_degree":9,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0006120","count":4},{"id":"GO:0007568","count":4},{"id":"GO:0051068","count":4},{"id":"GO:0045454","count":4}]},{"hash":"847512279045035808","title":"Unknown","description":"This cluster shows a mix of metabolic, stress-response, developmental, and neuroendocrine terms with no single dominant function, so no cohesive label can be assigned.","confidence":"","size":10,"edges":12,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0046168","count":3},{"id":"GO:0006915","count":3},{"id":"GO:0045471","count":2},{"id":"GO:0042742","count":2},{"id":"GO:2000648","count":2}]},{"hash":"2130918591988930548","title":"Unknown","description":"The terms are scattered across metabolism, epigenetics, development, redox biology, RNA regulation, and signaling, with no clear shared pathway or function tying the proteins together. Several terms are obsolete or generic, so there isn\u2019t a coherent theme to label the cluster meaningfully.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000466","count":1},{"id":"GO:0080111","count":1},{"id":"GO:0007568","count":1},{"id":"GO:0003335","count":1},{"id":"GO:0045454","count":1}]},{"hash":"1539952383582267369","title":"GPCR-cAMP and Guanylyl Cyclase Signaling","description":"The cluster centers on cAMP production and GPCR/guanylyl cyclase\u2013mediated signaling, including adenosine/adrenergic receptor pathways and forskolin response, with additional links to light and hypoxia sensing, suggesting a cohesive intracellular signaling module.","confidence":"High","size":10,"edges":9,"triangles":0,"max_degree":9,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0006171","count":5},{"id":"GO:1900194","count":5},{"id":"GO:0070483","count":5},{"id":"GO:0007168","count":5},{"id":"GO:0001973","count":5}]},{"hash":"425753042981847647","title":"Unknown","description":"The GO terms are highly diverse, spanning infection structure formation, glycosylation, lactose biosynthesis, various developmental and signaling processes, and cellular proliferation/regulation, with no clear shared function or pathway for the cluster, and no edges connecting proteins, so a confident, specific label cannot be assigned.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0075015","count":2},{"id":"GO:0006486","count":2},{"id":"GO:0005989","count":2},{"id":"GO:0060054","count":2},{"id":"GO:0045880","count":2}]},{"hash":"605501822746078589","title":"Potassium Channel Clustering and Neuro-Cardiac Signaling","description":"This cluster centers on voltage-gated potassium channel clustering and signaling that influences neuronal synaptic plasticity (long-term potentiation, postsynaptic calcium regulation) as well as cardiac development and stress-related cardiac hypertrophy. The presence of GTPase regulation and protein methylation suggests broader signaling modulation, while a few terms like bioluminescence may be noise. Overall, the pattern points to ion-channel organization linked to neural and cardiac signaling pathways.","confidence":"Medium","size":10,"edges":9,"triangles":0,"max_degree":8,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0045163","count":7},{"id":"GO:0007507","count":7},{"id":"GO:1903799","count":6},{"id":"GO:1900271","count":6},{"id":"GO:0099566","count":6}]},{"hash":"1323876738920764887","title":"Mucosal macrophage lipid remodeling and inflammation","description":"Many proteins cluster around lipid remodeling (phosphatidylethanolamine and phosphatidylserine acyl-chain remodeling) and lipid storage regulation, paired with production of inflammatory mediators (arachidonate secretion, leukotriene biosynthesis) and macrophage/inflammatory signaling (innate mucosal immunity, regulation of macrophage activation, foam cell differentiation, IL-1 production, Treg differentiation). This suggests a lipid-driven inflammatory program in mucosal tissues centered on macrophage activity.","confidence":"High","size":10,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0036152","count":2},{"id":"GO:0010744","count":2},{"id":"GO:0002227","count":2},{"id":"GO:0050482","count":2},{"id":"GO:0019370","count":2}]},{"hash":"2261746687321529413","title":"ER-Golgi Trafficking and Unfolded Protein Response","description":"This cluster is dominated by GO terms for ER-to-Golgi vesicle transport and the unfolded protein response, pointing to a secretory pathway and ER stress\u2013related functions as the core theme. Additional terms hint at related signaling and gene regulation processes, but the primary pattern centers on protein trafficking and stress response in the secretory pathway.","confidence":"Medium","size":10,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":3},{"id":"GO:0006986","count":2},{"id":"GO:2000324","count":2},{"id":"GO:0043278","count":2},{"id":"GO:0010288","count":2}]},{"hash":"1373882621433447573","title":"Genome regulation and chromosome dynamics","description":"The cluster is enriched for chromatin remodeling, heterochromatin formation, transcriptional control, DNA replication, and meiosis-related chromosome pairing and spindle assembly, all pointing to genome organization and chromosome dynamics during the cell cycle and meiosis (with some outliers like a cocaine response term). ","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":4},{"id":"GO:0043044","count":3},{"id":"GO:0016049","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0006260","count":2}]},{"hash":"1225677733311948135","title":"Unknown","description":"There are no shared GO terms or network connections among the proteins (no edges, no triangles, and no top terms), so no clear function theme emerges.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2099455113107326170","title":"GPCR-Mediated Cardiovascular and CNS Signaling","description":"The cluster is enriched in GO terms for adenylate cyclase-activating GPCR signaling, including dopamine receptor pathways and prostaglandin responses, with links to regulation of blood pressure and renin secretion, suggesting a core function in neuroendocrine and cardiovascular GPCR signaling. Additional terms on astrocyte chemotaxis and peptide response indicate CNS-related signaling contexts, while an electron transport chain term may reflect incidental metabolic components rather than a core cluster theme.","confidence":"High","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0007191","count":2},{"id":"GO:1900135","count":2}]},{"hash":"618533983211670122","title":"Unknown","description":"The GO terms describe varied developmental and signaling processes in different tissues (heart/right ventricle formation, pulmonary artery morphogenesis, distal tubule development, cerebellar Purkinje cell layer development) plus regulatory signaling (Smoothened/Hedgehog, GnRH response) and other scattered processes like calcium import and blood coagulation, without a clear common function binding the proteins. Therefore no cohesive theme, label as Unknown.","confidence":"","size":10,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090280","count":1},{"id":"GO:0061156","count":1},{"id":"GO:0072017","count":1},{"id":"GO:0097211","count":1},{"id":"GO:0045608","count":1}]},{"hash":"1640578408164655198","title":"Proteostasis and stress response","description":"The cluster is enriched for protein quality control pathways (aggresome assembly, ubiquitin-dependent ERAD, sumoylation) and oxidative stress response, with additional links to vesicle formation, microtubule dynamics, and nucleic/cargo transport (mRNA export). This points to a cohesive proteostasis network activated under stress, rather than a single highly specific function.","confidence":"Medium","size":9,"edges":4,"triangles":1,"max_degree":2,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006406","count":6},{"id":"GO:0030433","count":5},{"id":"GO:0070842","count":5},{"id":"GO:0034599","count":4},{"id":"GO:0051301","count":4}]},{"hash":"666835124690049794","title":"Chromatin remodeling and transcriptional regulation","description":"The top GO terms cluster around chromatin and transcription control: histone H4-K5 acetylation and nucleosome mobilization (chromatin modification), subtelomeric heterochromatin formation (chromatin state), transcription initiation at RNA polymerase II promoter, and regulatory ncRNA\u2013mediated post-transcriptional silencing (RNA-based gene regulation). Additional terms like ribosome biogenesis and responses to IL-4 or Wnt signaling may reflect broader regulatory connections to gene expression, but the dominant signal is chromatin state and transcriptional control.","confidence":"Medium","size":9,"edges":12,"triangles":6,"max_degree":6,"top_function":"ribosome biogenesis","top_go_terms":[{"id":"GO:0032147","count":3},{"id":"GO:0042254","count":3},{"id":"GO:0071353","count":2},{"id":"GO:2000096","count":1},{"id":"GO:0016246","count":1}]},{"hash":"93218513395180042","title":"Neuronal development and synaptic signaling","description":"Based on terms like hippocampus development, excitatory postsynaptic potential, positive regulation of axon extension, and signaling pathways (canonical Wnt, JNK, PI3K), the proteins appear enriched for neural growth and synaptic regulation. A single term on mast cell degranulation is an outlier relative to the dominant neuronal theme.","confidence":"High","size":9,"edges":22,"triangles":35,"max_degree":7,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0033138","count":9},{"id":"GO:0050771","count":9},{"id":"GO:0043552","count":9},{"id":"GO:0021766","count":9},{"id":"GO:0043304","count":9}]},{"hash":"1739750764971405747","title":"Developmental Signaling and Cell Adhesion","description":"The GO terms are dominated by developmental processes (ectoderm formation, cervix development, nephron tubule differentiation) and cellular adhesion (cell-matrix adhesion, cell-cell junction organization), with supporting signaling and regulatory terms. Although there is no direct interaction among proteins in this cluster, the recurring theme centers on development and adhesion.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060396","count":1},{"id":"GO:0007160","count":1},{"id":"GO:0010735","count":1},{"id":"GO:0001705","count":1},{"id":"GO:0035195","count":1}]},{"hash":"2217331902808497214","title":"ER\u2013Golgi vesicle trafficking","description":"The dominant GO terms cluster around intracellular transport involving the ER and Golgi, including ER-to-Golgi, intra-Golgi, and retrograde vesicle transport, i.e., vesicle trafficking and protein sorting. Some terms about cobalamin transport/metabolism also relate to transport processes but are less central to this cluster\u2019s core function. Thus, ER\u2013Golgi vesicle trafficking best captures the shared function.","confidence":"High","size":9,"edges":8,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0035987","count":2},{"id":"GO:0015889","count":1},{"id":"GO:0006824","count":1},{"id":"GO:0009235","count":1},{"id":"GO:0015031","count":1}]},{"hash":"1020604713944800484","title":"Dopaminergic pain and sensory processing","description":"This cluster is dominated by GO terms related to pain perception and its regulation, sensory gating (prepulse inhibition), and responses to dopaminergic drugs (morphine, amphetamine) alongside dopamine receptor signaling and glutamatergic transmission. Together these suggest a coherent theme of neural signaling for pain modulation and sensory processing, modulated by dopamine and related pathways. While a couple terms touch on related domains like thermogenesis and learning, the core motif is dopaminergic control of pain sensing and sensory gating. ","confidence":"Medium","size":9,"edges":2,"triangles":0,"max_degree":2,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0060134","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0043278","count":5}]},{"hash":"457482414629791971","title":"Unknown","description":"Unknown","confidence":"","size":9,"edges":16,"triangles":13,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006412","count":4},{"id":"GO:0000463","count":2},{"id":"GO:0042273","count":2},{"id":"GO:0031167","count":1},{"id":"GO:0001843","count":1}]},{"hash":"1665108746964138864","title":"Unknown","description":"The top GO terms reflect a wide mix of amino acid biosynthesis/catabolism, lipid biosynthesis, transcription, and signaling pathways (Notch and plant immune SA signaling), with no single coherent functional theme across the cluster.","confidence":"","size":9,"edges":36,"triangles":84,"max_degree":8,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0019878","count":5},{"id":"GO:0007219","count":5},{"id":"GO:0042853","count":5},{"id":"GO:0097053","count":5},{"id":"GO:0000105","count":4}]},{"hash":"137792556693876176","title":"Redox Stress Response and Metabolic Processes","description":"This cluster centers on redox-related activities (oxidation-reduction, nitrosative stress) and stress-responsive signaling (lipopolysaccharide response), alongside diverse metabolic pathways (retinol metabolism, fatty acid oxidation, lignin biosynthesis, sugar phosphate biosynthesis), pointing to a general theme of metabolic adjustment under redox or immune stress.","confidence":"Medium","size":9,"edges":26,"triangles":45,"max_degree":7,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0055114","count":6},{"id":"GO:0032496","count":6},{"id":"GO:0051409","count":5},{"id":"GO:0042572","count":5},{"id":"GO:0006116","count":5}]},{"hash":"1339523240016427107","title":"Unknown","description":"The proteins touch widely different processes, from hair follicle development and bone resorption to dopamine signaling, vesicle trafficking, copper homeostasis, phosphorylation, immune cell clustering, glial differentiation, lysosomal organization, and synaptic potential regulation. This broad, heterogeneous mix lacks a single cohesive functional theme to name a specific cluster label.","confidence":"","size":9,"edges":6,"triangles":0,"max_degree":3,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060789","count":3},{"id":"GO:0045453","count":3},{"id":"GO:0051586","count":3},{"id":"GO:0048194","count":3},{"id":"GO:0006878","count":3}]},{"hash":"725517409713448470","title":"Unknown","description":"The top GO terms are diverse and largely unrelated: unfolded protein response, photoreceptor outer segment localization, cell division, hormone receptor complex assembly, and several obsolete terms. With no consistent functional theme across the 9 proteins, there isn't a coherent function to name the cluster.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":1},{"id":"GO:1903546","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0009938","count":1},{"id":"GO:1903070","count":1}]},{"hash":"2211921835794290477","title":"Cell Division and Translation","description":"The cluster is enriched for cell-cycle and mitotic terms (cell cycle, exit from mitosis, meiotic chromosome alignment, division septum assembly) along with translation-related terms (cytoplasmic translation, ribosomal large subunit export). This points to a cohesive theme of cell division coordinating with protein synthesis machinery, with a few developmental process terms appearing as broader context.","confidence":"Medium","size":9,"edges":11,"triangles":2,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0051301","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0007049","count":1}]},{"hash":"462040959703977244","title":"Vitamin D\u2013related metabolism and detoxification","description":"Most terms cluster around vitamin D biology (calcitriol biosynthesis from calciol, response to vitamin D, vitamin D catabolic process) and related metabolic/detoxification processes (dibenzo-p-dioxin catabolic process, isoquinoline alkaloid metabolism, oxidative demethylation, copper ion response). A few terms (brassinosteroid homeostasis, tongue muscle differentiation) appear less related and may reflect broader or context-specific annotations. Overall, the cluster points to small-molecule metabolism and detoxification with Vitamin D\u2013related pathways as the dominant theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010268","count":4},{"id":"GO:0071280","count":4},{"id":"GO:0036378","count":4},{"id":"GO:2001037","count":4},{"id":"GO:0019341","count":4}]},{"hash":"361328171629288","title":"Unknown","description":"The top GO terms cover development across many tissues (trophoblast, skin, nails, heart, hematopoietic cells) as well as ion transport and synaptic plasticity. There isn't a single shared biological process or molecular function tying them all together, suggesting the cluster comprises proteins with diverse roles rather than a cohesive pathway.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061450","count":1},{"id":"GO:0098703","count":1},{"id":"GO:0048172","count":1},{"id":"GO:0043588","count":1},{"id":"GO:0006883","count":1}]},{"hash":"301435527163906633","title":"Innate Immune Signaling and NF-kB Regulation","description":"This cluster is enriched for GO terms related to innate immunity and NF-kappaB signaling, such as innate immune response and positive regulation of canonical NF-kappaB signal transduction. The presence of phosphorylation/dephosphorylation terms and ERK cascade regulation supports a broader theme of signaling control; some terms like cell division and decidualization are more peripheral and may reflect annotation noise. Overall, the dominant theme is immune signaling and transcriptional regulation.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045087","count":2},{"id":"GO:0043123","count":2},{"id":"GO:0006919","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0016310","count":1}]},{"hash":"462988860177858249","title":"Unknown","description":"The terms show a mix of regulatory processes across gene expression, signaling, protein modification, and localization (ribosomal subunit export; NF-kappaB and estrogen receptor regulation; ubiquitin-proteasome degradation; ufmylation; ER targeting). There isn't a clear, single biological function tying the cluster together, so it can't be confidently labeled with a specific function.","confidence":"","size":9,"edges":8,"triangles":0,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0000055","count":1},{"id":"GO:0061101","count":1},{"id":"GO:0033146","count":1},{"id":"GO:1903721","count":1},{"id":"GO:0032436","count":1}]},{"hash":"2183075699531645088","title":"Unknown","description":"The GO terms span plant hormone homeostasis, metal ion response, vitamin D metabolism, xenobiotic/dioxin processing, alkaloid metabolism, immune regulation, and muscle differentiation, with no single cohesive function tying the proteins together. This lack of a clear shared theme leads to an Unknown label.","confidence":"","size":9,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010268","count":7},{"id":"GO:0071280","count":7},{"id":"GO:0036378","count":7},{"id":"GO:2001037","count":7},{"id":"GO:0019341","count":7}]},{"hash":"254385386258316773","title":"Developmental Transcription Regulation","description":"This cluster centers on transcriptional control (GO:0006355, GO:0010735, GO:0000122) and developmental processes (GO:0021983, GO:0007275), suggesting a role in regulating gene expression during development, with some ancillary signals in cytoskeletal remodeling and redox-associated processes.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0010735","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0006355","count":3},{"id":"GO:0030042","count":3},{"id":"GO:0007275","count":3}]},{"hash":"1493952602503827119","title":"Mitotic Cell Cycle and Chromosome Cohesion","description":"This cluster is dominated by mitosis and cell cycle terms (mitotic cell cycle, cell division, mitotic sister chromatid cohesion), with supporting signals from gene expression regulation and ubiquitination, but the core theme is mitotic regulation and chromatid cohesion.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0070979","count":2},{"id":"GO:0006349","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051301","count":2}]},{"hash":"2288525551546803933","title":"Amino acid, nucleotide, and carbohydrate metabolism","description":"The top GO terms cluster around biosynthesis of amino acids (glutamine, histidine, tryptophan), GMP nucleotide biosynthesis, and general carbohydrate metabolism (gluconeogenesis, glucose starvation response), indicating a metabolism-centric protein set focused on biosynthetic pathways, with one outlier retina development annotation. ","confidence":"High","size":9,"edges":14,"triangles":6,"max_degree":8,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":2},{"id":"GO:0000105","count":2},{"id":"GO:0006177","count":2},{"id":"GO:0045722","count":2},{"id":"GO:0000162","count":2}]},{"hash":"1081495608608310555","title":"ECM adhesion and embryonic eye morphogenesis","description":"The cluster\u2019s top GO terms cluster around extracellular matrix interactions (heterophilic cell-cell adhesion, cell-matrix adhesion, elastic fiber assembly) and development, especially embryonic eye morphogenesis, suggesting roles in ECM organization and early eye formation. Immune/coagulation terms appear as secondary associations but do not define the core theme.","confidence":"Medium","size":9,"edges":13,"triangles":4,"max_degree":6,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0007157","count":9},{"id":"GO:0006590","count":9},{"id":"GO:0007160","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0030195","count":8}]},{"hash":"2107059254970438103","title":"Vascular development and inflammatory signaling","description":"The terms point to vascular biology and immune involvement: regulation of vasoconstriction, PDGF signaling, VEGF response, and heart development suggest vascular and cardiovascular roles; inflammatory response and complement activation add an immune dimension. A few neural terms exist but are less representative of the core theme. Overall, the cluster seems tied to vascular development with immune/inflammatory signaling.","confidence":"Medium","size":9,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2000821","count":3},{"id":"GO:0010641","count":3},{"id":"GO:0045907","count":3},{"id":"GO:0043547","count":3},{"id":"GO:0007507","count":3}]},{"hash":"400020545105008010","title":"Neuromuscular signaling and skeletal development","description":"The cluster\u2019s strongest terms point to neuromuscular function (synaptic vesicle clustering; neuromuscular process controlling posture) and skeletal development (bone mineralization; bone morphogenesis), suggesting a shared theme of coordinated muscle\u2013bone signaling. Other terms like immune and metabolic responses appear secondary and do not define the main theme of this group.","confidence":"Medium","size":9,"edges":9,"triangles":1,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0097091","count":2},{"id":"GO:0060038","count":2},{"id":"GO:0009607","count":1},{"id":"GO:0050884","count":1},{"id":"GO:0035456","count":1}]},{"hash":"46087340721888266","title":"Cell cycle and ribosome biogenesis","description":"The cluster strongly features cell cycle and cell division terms (cell cycle, cell division), together with translation- and ribosome-related processes (cytoplasmic translation, ribosomal large subunit export from nucleus) and protein assembly (protein homooligomerization). This points to coordination of cell proliferation with ribosome biogenesis and protein synthesis, despite some ancillary signaling cues (vitamin D and interferon responses). Therefore, the label reflects the central theme of growth/division linked to protein production machinery.","confidence":"Medium","size":9,"edges":10,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":3},{"id":"GO:0007049","count":3},{"id":"GO:0033280","count":2},{"id":"GO:0010636","count":2},{"id":"GO:0045053","count":2}]},{"hash":"622879927453950942","title":"Developmental Signaling and Morphogenesis","description":"This cluster centers on growth-factor receptor signaling and morphogenetic pathways, including receptor tyrosine kinase activation, HGF, VEGF, Hedgehog pathway regulation, and neural crest and neuronal migration, plus hair cell differentiation and renal artery morphogenesis. Taken together, these GO terms reflect signaling-driven development across neural, vascular, and organogenesis contexts, with an outlier immune term (complement activation).","confidence":"High","size":9,"edges":12,"triangles":2,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007171","count":9},{"id":"GO:0001867","count":9},{"id":"GO:0048012","count":8},{"id":"GO:0036486","count":8},{"id":"GO:0021828","count":8}]},{"hash":"75222477062374546","title":"Transmembrane nutrient transport","description":"The top GO terms are dominated by various transmembrane transports (D-glucose, pantothenate, myo-inositol, biotin) and sodium export, suggesting a coherent theme of membrane transporters handling nutrients and ions. There are a few unrelated terms (antibacterial humoral response, development, copulation), but the primary signal points to membrane transport. Confidence: High.","confidence":"","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0019731","count":2},{"id":"GO:0071436","count":1},{"id":"GO:1904659","count":1},{"id":"GO:0008292","count":1},{"id":"GO:0015887","count":1}]},{"hash":"1696491204848397679","title":"Cardiac morphogenesis and endothelial differentiation","description":"Top terms center on heart development and endothelial differentiation (venous endothelial differentiation, right atrium morphogenesis, Notch signaling in the heart field) and include a mechanical-stimulus response, pointing to a cluster specialized for cardiac morphogenesis and mechanoresponsive endothelial/cardiac cells. Other terms appear peripheral.","confidence":"High","size":9,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0060843","count":6},{"id":"GO:0033280","count":6},{"id":"GO:0003270","count":6},{"id":"GO:0003213","count":6},{"id":"GO:0071260","count":6}]},{"hash":"1026906475758709342","title":"Cytoskeleton regulation and signaling","description":"This cluster highlights proteins involved in cytoskeletal dynamics (actin cortical patch localization, dendritic spine maintenance) and signaling control (positive regulation of GTPase activity, TGF-beta\u2013stimulated responses), with additional hints of cell fusion/differentiation and chemotactic movement. The shared theme appears to be regulation of cell shape and signaling pathways rather than a single uniform process, suggesting a label focused on cytoskeleton regulation and signaling. The sparse connectivity (one edge) aligns with a broad, functionally related set rather than a tightly clustered module.","confidence":"Medium","size":9,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0050894","count":2},{"id":"GO:0051044","count":2},{"id":"GO:2000821","count":2},{"id":"GO:0044379","count":2},{"id":"GO:0071560","count":2}]},{"hash":"1478419228461865858","title":"Synaptic vesicle exocytosis and neurotransmission","description":"The cluster is dominated by GO terms related to synaptic vesicle exocytosis, neurotransmitter transport and secretion, and synaptic plasticity (e.g., synaptic vesicle exocytosis, neurotransmitter transport, regulation of neurotransmitter secretion, long-term potentiation), indicating a cohesive theme around neuronal signaling and vesicle-mediated communication. Some pollen-related terms appear but do not override the core synaptic functions.","confidence":"High","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0080092","count":1},{"id":"GO:0035556","count":1},{"id":"GO:0010183","count":1},{"id":"GO:0006836","count":1},{"id":"GO:0046928","count":1}]},{"hash":"724056564536767242","title":"Innate immunity and tissue remodeling","description":"The GO terms show a clear tilt toward innate immune responses (lipopolysaccharide response, defense against Gram-negative bacteria, TLR9 signaling, IL-6 production) alongside collagen/fibril organization and bone trabecula regulation, suggesting a link between immune signaling and extracellular matrix/tissue remodeling.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071222","count":3},{"id":"GO:0016525","count":3},{"id":"GO:0030199","count":3},{"id":"GO:0009620","count":2},{"id":"GO:1900155","count":2}]},{"hash":"1106442160784017843","title":"Immunoregulation and coagulation modulators","description":"This cluster is dominated by GO terms describing negative regulation of immune responses (inflammatory response, type 2 immunity, T cell proliferation, IL-4 production, IgE isotype switching), with blood coagulation appearing among the top terms. The convergence on suppression of immune activity, plus the coagulation reference, suggests proteins that modulate both immune signaling and coagulation pathways. Other transport-related terms are present but appear peripheral to the main theme.","confidence":"Medium","size":9,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050728","count":2},{"id":"GO:0007596","count":2},{"id":"GO:0002829","count":1},{"id":"GO:0051224","count":1},{"id":"GO:0032713","count":1}]},{"hash":"626115384756849966","title":"Oocyte polarity and oskar mRNA localization","description":"The set is dominated by terms tied to oocyte axis formation, including oocyte microtubule cytoskeleton polarization, pole plasm protein localization, and oskar mRNA localization, which together point to posterior patterning and mRNA localization in oocytes. Supporting terms about ribosome-related processes and mRNA processing fit the broader context of mRNA translation control during oogenesis, but the clearest theme is polarity establishment and pole plasm/oskar localization. This makes the label both specific and representative of the cluster\u2019s core function.","confidence":"High","size":8,"edges":7,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0002181","count":2},{"id":"GO:0032259","count":1},{"id":"GO:0010038","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0000184","count":1}]},{"hash":"183598418173100283","title":"Nuclear mRNA processing and export","description":"This cluster shows enrichment for mRNA export, stabilization, and poly(A) tail regulation, with a link to small-subunit processome assembly, indicating a shared role in nuclear mRNA maturation and export.","confidence":"Medium","size":8,"edges":28,"triangles":56,"max_degree":7,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:1902625","count":5},{"id":"GO:0034462","count":5},{"id":"GO:1901407","count":5},{"id":"GO:0006406","count":5},{"id":"GO:0031047","count":5}]},{"hash":"901406170019738223","title":"RNA Pol II Transcription Initiation & Regulation","description":"The top GO terms cluster around DNA-templated transcription and RNA Polymerase II promoter activities, including transcription initiation, preinitiation complex assembly, and open complex formation, indicating a focus on transcription initiation and its regulation. A few outlier terms (Pol III promoter initiation, viral transcription) are present but do not outweigh the main theme.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006351","count":2},{"id":"GO:0006355","count":2},{"id":"GO:0070893","count":1},{"id":"GO:0090074","count":1},{"id":"GO:0006367","count":1}]},{"hash":"1919375407931173966","title":"Transmembrane Transporters for Ions and Small Molecules","description":"The top GO terms point to a broad set of transmembrane transport activities (ions like K+, Na+, nitrate/nitrite, phosphate) and small molecule substrates (galactose, vitamin, fucose, 4-hydroxyphenylacetate), suggesting these proteins function as membrane transporters rather than a single substrate class.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0035435","count":1},{"id":"GO:0035725","count":1},{"id":"GO:0035461","count":1}]},{"hash":"732596177305168413","title":"Ubiquitin-Dependent Degradation and NF-kappaB/JNK Regulation","description":"The proteins cluster around ubiquitin-mediated proteolysis (ubiquitin-dependent degradation, autoubiquitination) and signaling pathways such as JNK cascade and NF-kappaB activation, with supporting hints from histone ubiquitination and chromatin-related processes. This suggests a function in coordinated protein turnover coupled to transcriptional signaling, rather than a single enzymatic activity. The presence of immune-related terms like V(D)J recombination adds a broader chromatin/immune context but still aligns with ubiquitin-regulated regulation of signaling and gene expression.","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0070535","count":3}]},{"hash":"1508133586689405774","title":"Neural Development and Synaptic Organization","description":"This cluster is dominated by GO terms tied to neuronal development and synaptic structure/function: dendrite development regulation, synapse organization, axonal protein localization at juxtaparanodes, retina morphogenesis, and BMP/TGF-beta signaling modulation\u2014all pointing to neural differentiation and connectivity processes. A few terms pertain to broader developmental or immune signaling, but the core theme centers on neural development and synaptic organization.","confidence":"High","size":8,"edges":27,"triangles":50,"max_degree":7,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:2001202","count":8},{"id":"GO:0001954","count":8},{"id":"GO:0060068","count":8},{"id":"GO:0050808","count":8},{"id":"GO:0070106","count":8}]},{"hash":"2144952774714281339","title":"Embryonic development and organogenesis","description":"This cluster shows multiple GO terms tied to embryogenesis, tissue differentiation, and organ formation (placental development, EMT in heart development, left-right patterning, cartilage formation, pancreatic cell development, endocrine development), suggesting proteins involved in broad developmental programs rather than a single pathway.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060707","count":3},{"id":"GO:0035270","count":3},{"id":"GO:0003198","count":3},{"id":"GO:0003323","count":3},{"id":"GO:0060972","count":3}]},{"hash":"44703454412003899","title":"Developmental differentiation and cytoskeletal dynamics","description":"This cluster centers on developmental processes such as lung development and neuron differentiation/migration, alongside cytoskeletal organization and cell cycle regulation, with additional hints of translation regulation and IL-4\u2013related signaling. The common thread appears to be proteins coordinating tissue morphogenesis and cytoskeletal remodeling during development, with broader signaling roles.","confidence":"Medium","size":8,"edges":18,"triangles":19,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0071353","count":4},{"id":"GO:0030324","count":3},{"id":"GO:0014883","count":2},{"id":"GO:0030182","count":2},{"id":"GO:0001764","count":2}]},{"hash":"2109508686139207444","title":"Unknown","description":"The top GO terms span neural signaling (amphetamine response, pain perception, prepulse inhibition, glutamatergic transmission), immune processes (leukocyte migration, granuloma formation), and developmental/remodeling processes (embryo implantation, collagen catabolic process, intramembranous ossification), with no clear single function linking all proteins. Therefore there isn\u2019t a coherent shared theme to name the cluster confidently.","confidence":"","size":8,"edges":7,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0001975","count":2},{"id":"GO:0051930","count":2},{"id":"GO:0060134","count":2},{"id":"GO:0051967","count":2},{"id":"GO:0007566","count":2}]},{"hash":"444599161392916882","title":"Membrane Ion and Metabolite Transport","description":"The top GO terms converge on transmembrane transport for a range of ions (K+, Na+, nitrate, nitrite, phosphate) and small molecules (galactose, fucose, vitamins, 4-hydroxyphenylacetate), suggesting these proteins act as membrane transporters with diverse substrates rather than a single substrate class.","confidence":"High","size":8,"edges":9,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":1},{"id":"GO:0071718","count":1},{"id":"GO:0015707","count":1},{"id":"GO:0035435","count":1},{"id":"GO:0035725","count":1}]},{"hash":"723468255550556079","title":"Diverse Metabolite Biosynthesis","description":"This cluster centers on multiple biosynthetic processes, spanning retinol/retinal metabolism, steroid (testosterone/androgen) and glucocorticoid synthesis, anthocyanin pigment biosynthesis, antibiotic biosynthesis, and other small-molecule pathways. The common thread is production of diverse metabolites rather than a single cohesive pathway, suggesting a broad biosynthetic theme.","confidence":"Medium","size":8,"edges":15,"triangles":10,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":5},{"id":"GO:0017000","count":5},{"id":"GO:0042572","count":4},{"id":"GO:0042619","count":3},{"id":"GO:0042574","count":3}]},{"hash":"282086776987477114","title":"Chromatin organization and transcription regulation","description":"The majority of top GO terms revolve around chromatin-related processes (rDNA heterochromatin formation, chromatin assembly, nucleosome mobilization, chromatin localization, DNA replication-dependent chromatin assembly) and transcriptional control (negative regulation of transcription by RNA polymerase II). The presence of spermatid development and sperm DNA condensation terms suggests chromatin remodeling during gametogenesis, which fits the chromatin theme, while a couple of terms (Rho signaling, mucosal immunity) appear as outliers or noise. Overall, the cluster is best described by chromatin organization and transcription regulation.","confidence":"High","size":8,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0000183","count":2},{"id":"GO:0035023","count":1},{"id":"GO:0007286","count":1},{"id":"GO:0035093","count":1},{"id":"GO:0000122","count":1}]},{"hash":"943448277158372260","title":"Nucleic acid metabolism and gene expression regulation","description":"Top GO terms include DNA recombination, DNA demethylation (obsolete), and regulation of mRNA stability, pointing to a shared theme of nucleic acid processing and control of gene expression. Some other terms appear unrelated or obsolete, but the core signals are nucleic-acid\u2013related processes.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA recombination","top_go_terms":[{"id":"GO:0006310","count":3},{"id":"GO:2000466","count":2},{"id":"GO:0080111","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0003335","count":2}]},{"hash":"1152557232418031737","title":"Neuronal Synaptic Regulation and Neurodevelopment","description":"The cluster shows strong enrichment for synaptic vesicle cycling regulation (endocytosis/exocytosis), excitatory postsynaptic potentials, and substantia nigra development, pointing to a neuronal synaptic function and brain development. Some bone and skin development terms, plus xenobiotic/ER stress responses, appear but are less central to the dominant neural theme.","confidence":"Medium","size":8,"edges":8,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0043931","count":5},{"id":"GO:1900101","count":4},{"id":"GO:1900242","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0021762","count":3}]},{"hash":"506743103439797518","title":"Integrin signaling and developmental remodeling","description":"The top GO terms cluster around integrin-mediated signaling, angiogenesis, migration, and neural guidance (e.g., synapse assembly, axon guidance, VEGF signaling, fibroblast migration), which together point to adhesion-related signaling guiding tissue remodeling during development and vascular/nerve formation. Some terms (like molting and symbiont hemolysis) are more peripheral, but the core themes support integrin signaling driving developmental remodeling. ","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"cell adhesion","top_go_terms":[{"id":"GO:0007229","count":4},{"id":"GO:0051965","count":4},{"id":"GO:0018996","count":4},{"id":"GO:0042535","count":4},{"id":"GO:0045766","count":4}]},{"hash":"471788167337512963","title":"Developmental Regulation and Chromatin Remodeling","description":"The set includes developmental morphogenesis terms (right ventricular myocardium, forelimb, olfactory nerve development) along with chromatin-related processes (nucleosome mobilization, histone exchange, histone dimer displacement) and transcription start site regulation. This combination points to a module that coordinates gene expression during development via chromatin remodeling and transcriptional control. Some terms are older/less coherent (e.g., biofilm adhesion, GTPase regulation), but the dominant signal supports a developmental regulation/chromatin remodeling theme.","confidence":"Medium","size":8,"edges":20,"triangles":18,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0003226","count":2},{"id":"GO:0021553","count":2},{"id":"GO:1900189","count":2},{"id":"GO:0035128","count":2}]},{"hash":"2281072769502271428","title":"Actin Cytoskeleton Remodeling and Cell Migration","description":"This group is characterized by strong enrichment for actin cytoskeleton organization, protrusion assembly (filopodia and lamellipodia), and Rho-regulated signaling, which together underpin dynamic cytoskeletal remodeling, adhesion, and cell migration. Additional terms (insulin signaling, heart development, myelin maintenance) reflect broader contexts where cytoskeletal dynamics are important, but the dominant theme across terms is actin-driven movement and structural remodeling.","confidence":"High","size":8,"edges":10,"triangles":1,"max_degree":5,"top_function":"microtubule-based movement","top_go_terms":[{"id":"GO:0035023","count":7},{"id":"GO:1900026","count":6},{"id":"GO:0008286","count":6},{"id":"GO:0032633","count":6},{"id":"GO:0016477","count":6}]},{"hash":"305857575529242182","title":"Synapse Assembly and Cadherin Adhesion","description":"The top GO terms prominently point to neuronal synapse organization (presynaptic active zone assembly; regulation of PSD-95 clustering) and cadherin-mediated cell adhesion, suggesting a core theme of synaptic structure and cell\u2013cell contacts. Other terms touch on unrelated developmental processes, which may reflect broad or pleiotropic functions, but the strongest signal remains synaptic organization and adhesion.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003192","count":3},{"id":"GO:0060901","count":3},{"id":"GO:0002315","count":3},{"id":"GO:0002314","count":3},{"id":"GO:0070445","count":3}]},{"hash":"2171161895236818584","title":"Neuronal stress response and apoptosis regulation","description":"The top GO terms cluster around neuronal apoptosis (neuron apoptotic process, negative regulation of neuron apoptotic process, intrinsic apoptotic signaling in response to ER stress) and cellular responses to hypoxia, which point to a regulatory network governing neuron fate under stress. Additional terms about retina development and male gonad development suggest broader developmental roles, while ubiquitination and transcription regulation imply cleanup and control of these pathways. Overall, the strongest common theme is neuronal stress signaling and apoptosis regulation, with developmental context as a broader hint.","confidence":"Medium","size":8,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0051402","count":2},{"id":"GO:0071456","count":2}]},{"hash":"538264410149369815","title":"Dopaminergic GPCR Signaling","description":"This cluster is dominated by GO terms for dopamine receptor signaling and GPCR cascades (adenylyl cyclase activation, GPCR-mediated signaling, and dopamine uptake regulation), with supportive terms pointing to prostaglandin responses and astrocyte chemotaxis, suggesting neuron\u2013glia dopaminergic signaling. The renin secretion term is peripheral to the main theme but does not contradict it. ","confidence":"High","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":8},{"id":"GO:1900135","count":8},{"id":"GO:2000458","count":8},{"id":"GO:1901652","count":8},{"id":"GO:0018298","count":8}]},{"hash":"286650110572553045","title":"Neuromuscular signaling and collagen biosynthesis","description":"The GO terms cluster around neural control of movement and Schwann cell activity (neuromuscular process, musculoskeletal movement, Schwann cell regulation) together with extracellular matrix production (collagen biosynthetic process) and secretory pathway involvement (ER to Golgi transport), suggesting a theme of neuromuscular signaling linked to ECM remodeling. Some terms are obsolete or peripheral, but the core pattern supports this interpretation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":1},{"id":"GO:0050884","count":1},{"id":"GO:0044257","count":1},{"id":"GO:0050881","count":1},{"id":"GO:0001306","count":1}]},{"hash":"594262843038679897","title":"Mitophagy and mitochondrial stress response","description":"The terms converge on mitochondrial maintenance under stress: mitophagy, regulation of respiration, and unfolded protein response point to mitochondrial quality control and proteostasis. Some entries are obsolete or less related (e.g., plant hormone signaling), but the core theme links mitochondrial stress response and protein homeostasis, with a note on photoreceptor outer segment localization reflecting specialized cellular contexts.","confidence":"Medium","size":8,"edges":7,"triangles":0,"max_degree":7,"top_function":null,"top_go_terms":[{"id":"GO:0010259","count":1},{"id":"GO:0043457","count":1},{"id":"GO:0000422","count":1},{"id":"GO:0006986","count":1},{"id":"GO:1903546","count":1}]},{"hash":"1496222205578775437","title":"Lipid remodeling and oxidative stress response","description":"This cluster is driven by phosphatidylcholine acyl-chain remodeling, with multiple associated stress responses (ethanol, lead ion, vitamin E) and oxidative processes (hydrogen peroxide catabolic), plus anti-apoptotic regulation and respiration. Together these terms point to a theme of lipid remodeling linked to cellular stress response and survival.","confidence":"High","size":8,"edges":8,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0036151","count":3},{"id":"GO:0045471","count":2},{"id":"GO:0043066","count":2},{"id":"GO:0033197","count":2},{"id":"GO:0007568","count":2}]},{"hash":"794471302142847617","title":"Embryonic and Organ Morphogenesis","description":"Based on the top GO terms, the cluster is enriched for developmental morphogenesis across organs (heart morphogenesis, embryonic forelimb morphogenesis, pituitary gland development, spermatid development) and related transcriptional/regulatory signals (DNA-templated transcription, peptidyl-serine phosphorylation). Although a couple of metabolic biosynthesis terms appear, the dominant theme points to developmental processes and organ formation. Therefore, the label emphasizes embryonic and organ morphogenesis with regulatory signaling as a core aspect.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":3},{"id":"GO:0003007","count":3},{"id":"GO:0017000","count":3},{"id":"GO:0009102","count":2},{"id":"GO:0021983","count":2}]},{"hash":"1976313101263002282","title":"Regulators of cellular processes","description":"This cluster centers on GO terms about negative and positive regulation across diverse pathways (apoptosis, proteolysis, GTPase activity, nitric oxide biosynthesis, stem cell proliferation), implying the proteins act as regulators rather than a single specific function. Despite several obsolete terms, the common theme is regulatory roles in multiple cellular processes.","confidence":"Medium","size":8,"edges":6,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0018032","count":1},{"id":"GO:0043066","count":1},{"id":"GO:1903629","count":1},{"id":"GO:0007568","count":1},{"id":"GO:1903052","count":1}]},{"hash":"1557256371540718075","title":"Vitamin and xenobiotic transmembrane transport","description":"The top GO terms are dominated by vitamin transmembrane transport (GO:0035461) and xenobiotic transmembrane transport (GO:0006855), each appearing twice, suggesting a shared function in moving small molecules across membranes. Several other terms touch unrelated areas (unfolded protein response, photoreceptor localization, plant hormone signaling, etc.), which may reflect annotation noise or pleiotropy in the included proteins. Overall, the strongest signal is membrane transport of small molecules, so the cluster can be labeled accordingly.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035461","count":2},{"id":"GO:0042891","count":2},{"id":"GO:0006855","count":2},{"id":"GO:0006986","count":1},{"id":"GO:1903546","count":1}]},{"hash":"596257167521465260","title":"Embryonic development and organogenesis","description":"The GO terms point to development across multiple organs and body plan formation (podocyte differentiation, ureter and circulatory system development, mesenchyme migration, spinal cord interneuron fate, left-right patterning). While some terms are peripheral or obsolete, the overarching theme is developmental processes and tissue organization, suggesting these proteins participate in organogenesis and patterning.","confidence":"Medium","size":8,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042297","count":1},{"id":"GO:0072112","count":1},{"id":"GO:0072358","count":1},{"id":"GO:0090131","count":1},{"id":"GO:0035947","count":1}]},{"hash":"1569318315068092972","title":"Developmental morphogenesis and signaling","description":"The set includes GO terms tied to morphogenesis and development across tissues (salivary gland branching, olfactory placode morphogenesis, lens fiber differentiation, axon guidance) plus signaling-related terms (erythropoietin-mediated signaling, monocyte chemotactic protein-1 production). The common thread is developmental morphogenesis governed by intercellular signaling rather than a single tissue-specific function, so Developmental morphogenesis and signaling seems the most representative label.","confidence":"Medium","size":8,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":1},{"id":"GO:0035584","count":1},{"id":"GO:0050925","count":1},{"id":"GO:0070486","count":1},{"id":"GO:0038162","count":1}]},{"hash":"708705965239525840","title":"Muscle and Vasculature Development Regulation","description":"The cluster center appears to be developmental regulation, with strong signals for positive regulation of myoblast differentiation and vasculogenesis, complemented by Notch signaling modulation and transcriptional control. Additional terms related to leukocyte adhesion to arterial endothelium and membrane proteolysis hint at broader vascular-development interactions, making a cohesive theme of coordinated muscle and blood vessel formation.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045663","count":2},{"id":"GO:2001214","count":1},{"id":"GO:0036138","count":1},{"id":"GO:0042264","count":1},{"id":"GO:0042265","count":1}]},{"hash":"1485394973125178363","title":"Neural Development and ECM Assembly","description":"The GO terms mostly point to nervous system development: substantia nigra development, axon development, neural retina development, and CNS myelination. There are also terms about extracellular matrix assembly and focal adhesion regulation, which support neural tissue formation and cell\u2013matrix interactions. A few terms like serotonin uptake regulation, phototaxis, and bone mineralization are peripheral but may relate to broader neural signaling or differentiation contexts. Overall this cluster seems centered on nervous system development with associated ECM remodeling.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051893","count":1},{"id":"GO:0051612","count":1},{"id":"GO:0042759","count":1},{"id":"GO:0085029","count":1},{"id":"GO:0021762","count":1}]},{"hash":"2164074315959430779","title":"Unknown","description":"Unknown","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":2},{"id":"GO:2000637","count":2},{"id":"GO:0007014","count":2},{"id":"GO:0061158","count":2},{"id":"GO:1902187","count":2}]},{"hash":"34361853047290420","title":"Immune Extrinsic Apoptosis and TNF Signaling","description":"The terms cluster around extrinsic apoptotic pathways mediated by death receptors, with regulation (positive/negative) and involvement of TNF signaling, necroptosis, and type I interferon pathways, all within an immune context (T cell homeostasis, thymus development). Some terms (decidualization, general development) are less directly tied but overall the dominant theme is immune-related apoptosis and inflammatory signaling via extrinsic pathways. Confidence: Medium","confidence":"","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902042","count":2},{"id":"GO:0043029","count":1},{"id":"GO:0019050","count":1},{"id":"GO:0060340","count":1},{"id":"GO:0097192","count":1}]},{"hash":"851386008864079425","title":"Actin Cytoskeleton Organization and Cell Migration","description":"These proteins show a clear emphasis on actin cytoskeleton organization and cell migration, with those two GO terms appearing most prominently. Additional terms related to endocytosis (pinocytosis) and cytoskeletal remodeling reinforce a theme of actin-driven membrane dynamics, though some terms are obsolete or tissue-specific (like lens morphogenesis), suggesting the core function is cytoskeletal regulation and movement rather than a single specialized process.","confidence":"Medium","size":8,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007346","count":2},{"id":"GO:0016477","count":2},{"id":"GO:0007605","count":2},{"id":"GO:2001275","count":2},{"id":"GO:0007205","count":2}]},{"hash":"208166762585639296","title":"Ubiquitin-Mediated Proteostasis","description":"The cluster is enriched for ubiquitination and SUMOylation processes (protein sumoylation, autoubiquitination), ERAD-related activity, and aggresome assembly, all central to ubiquitin/proteasome\u2013based protein quality control. The presence of these terms suggests a shared role in protein regulation and degradation rather than a single metabolic pathway, with additional stress-related regulatory terms supporting a proteostasis-focused theme.","confidence":"High","size":7,"edges":6,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016925","count":5},{"id":"GO:0051865","count":4},{"id":"GO:1903265","count":3},{"id":"GO:1905366","count":3},{"id":"GO:0070842","count":3}]},{"hash":"2278189176890533829","title":"Ubiquitin-Proteasome and ERAD Proteostasis","description":"The top GO terms point to ubiquitination (protein autoubiquitination), ER-associated degradation (ubiquitin-dependent ERAD pathway), regulation of proteasomal protein catabolic processes, and ER-related membrane insertion, all of which together indicate a module focused on ubiquitin-mediated protein turnover and ER quality control. Other terms like translation and mitochondrial dynamics appear as secondary connections, but the dominant theme is proteostasis via ubiquitin-proteasome/ERAD pathways.","confidence":"High","size":7,"edges":19,"triangles":25,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0051865","count":4},{"id":"GO:1903265","count":4},{"id":"GO:0006412","count":4},{"id":"GO:0030433","count":3},{"id":"GO:0006517","count":3}]},{"hash":"511598760528966416","title":"Angiogenesis and endothelial signaling","description":"The GO terms center on angiogenesis, endothelia cell migration, and cell-matrix adhesion, with associated signaling pathways (ERK/JNK) and IL-6 response, indicating a vascular development and signaling module. A couple of terms (e.g., sperm capacitation) seem unrelated noise, and the lack of edges suggests a loosely connected set; still, the dominant theme is angiogenic and endothelial signaling functions.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007160","count":2},{"id":"GO:1902042","count":2},{"id":"GO:0071354","count":2},{"id":"GO:0043536","count":2},{"id":"GO:0045766","count":2}]},{"hash":"556570035585170210","title":"RNA processing and mRNA export","description":"The cluster shows a clear enrichment for RNA metabolism terms: mRNA export from the nucleus, mRNA stabilization, regulation of poly(A) tail shortening, regulatory ncRNA-mediated gene silencing, and small-subunit processome (ribosome biogenesis) assembly. These collectively point to RNA processing and export as the core function of the group. A couple terms related to signaling are present but sparse and do not override the RNA-centric theme.","confidence":"High","size":7,"edges":12,"triangles":7,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0007218","count":1},{"id":"GO:0042811","count":1},{"id":"GO:1902625","count":1},{"id":"GO:0034462","count":1},{"id":"GO:1901407","count":1}]},{"hash":"742729366581468641","title":"Cytoskeleton signaling and proteostasis","description":"This cluster centers on cytoskeletal signaling and cell adhesion (integrin-mediated signaling, Rho signaling, microvillus assembly), with accompanying protein turnover processes (proteasome assembly, ubiquitin-dependent protein catabolic process). These together suggest a theme of signaling intertwined with cytoskeletal dynamics and protein degradation, though a few terms (e.g., chlorophyll biosynthesis, organ-specific differentiation) may be less related and represent noise. ","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007229","count":2},{"id":"GO:0035023","count":2},{"id":"GO:0030033","count":2},{"id":"GO:0071320","count":2},{"id":"GO:0048455","count":2}]},{"hash":"2101842790242916882","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0031126","count":1},{"id":"GO:0090503","count":1},{"id":"GO:0034414","count":1},{"id":"GO:0006364","count":1},{"id":"GO:0046677","count":1}]},{"hash":"1512692626318309299","title":"Ubiquitin-Proteasome\u2013Mediated Proteolysis and Cell Cycle","description":"Top GO terms indicate ubiquitin-dependent protein degradation (polyubiquitination, proteasomal catabolism) and SCF ligase activity, along with spindle assembly in meiosis, all pointing to tight regulation of protein levels during the cell cycle. Although a few terms refer to unrelated processes or are obsolete, the core signal is proteostasis linked to cell-cycle control via ubiquitination and degradation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070544","count":2},{"id":"GO:0021993","count":2},{"id":"GO:0031146","count":2},{"id":"GO:0051436","count":2},{"id":"GO:0007057","count":2}]},{"hash":"1988035699684095276","title":"Developmental Differentiation Regulators","description":"The cluster centers on regulatory processes governing cell fate and tissue development across lineages (blood, neural, endocrine) and stem cells. Although some terms are broad or obsolete, the dominant pattern is development/differentiation control.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045654","count":4},{"id":"GO:2000648","count":3},{"id":"GO:0021983","count":3},{"id":"GO:0060992","count":3},{"id":"GO:0010976","count":3}]},{"hash":"1889840824711456683","title":"DNA Repair and Genome Maintenance","description":"The GO terms cluster around DNA replication, nucleotide excision repair, mismatch repair, interstrand cross-link repair, homologous recombination regulation, and chromosome localization, indicating a coherent theme of DNA damage repair and genome maintenance. A single antibiotic-response term may reflect stress-induced repair, but the overall pattern strongly supports DNA repair functions.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":2},{"id":"GO:0006260","count":1},{"id":"GO:0036297","count":1},{"id":"GO:0006294","count":1},{"id":"GO:0010569","count":1}]},{"hash":"2006904156879383867","title":"Lectin- and Fc-receptor innate immunity","description":"The cluster is dominated by GO terms tied to innate immune recognition and signaling, including cellular response to fungal origin, lectin pathway complement activation, C-type lectin receptor signaling, Fc-gamma receptor signaling, and leukocyte adhesion-related processes. While there are a few development-related terms (mesonephric/metanephric development, lymph vessel morphogenesis), the strongest and most frequent annotations point to innate immune sensing and downstream signaling pathways, suggesting these proteins function in glycan- and antibody-mediated immune responses and leukocyte interactions.","confidence":"Medium","size":7,"edges":9,"triangles":7,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071226","count":4},{"id":"GO:0001867","count":4},{"id":"GO:0060355","count":3},{"id":"GO:0048012","count":3},{"id":"GO:0072177","count":3}]},{"hash":"2280262430811303445","title":"Unknown","description":"The top GO terms span Notch signaling, multiple biosynthetic pathways (amino acids, vitamins, lipids, porphyrin), transcription, and plant defense signaling, showing no single cohesive function to define the cluster. A clear, representative label cannot be inferred from these terms.","confidence":"","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":"DNA-templated transcription","top_go_terms":[{"id":"GO:0007219","count":3},{"id":"GO:0000105","count":3},{"id":"GO:0046511","count":3},{"id":"GO:0019878","count":3},{"id":"GO:0009236","count":3}]},{"hash":"1317385226901128846","title":"Mitotic Cell Cycle and ER-Golgi Trafficking","description":"The terms point to both mitotic processes (mitotic cell cycle, cell division, spindle assembly) and vesicle trafficking between the ER and Golgi (COPII budding, ER-Golgi transport), suggesting a cluster of proteins involved in cell proliferation coupled with secretory pathway functions, with developmental growth context.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0000278","count":4},{"id":"GO:0006890","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0090114","count":3},{"id":"GO:0007420","count":3}]},{"hash":"2214990813595857562","title":"Developmental and Immune Regulation","description":"This cluster shows a mix of metabolic, developmental, and immune/coagulation-related terms: carbohydrate metabolic process, cerebellar Purkinje cell layer development, immune signaling (complement receptor), regulation of immune and platelet-related processes (myeloid apoptosis, T cell homeostasis, integrin activation, fibrinolysis), and embryonic development hints (in utero development, thyroid hormone generation). The diverse but interconnected themes suggest a cluster tied to development with immune and metabolic regulation, hence Developmental and Immune Regulation with Medium confidence. ","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0005975","count":4},{"id":"GO:0021680","count":3},{"id":"GO:0033033","count":3},{"id":"GO:0046013","count":3},{"id":"GO:0002430","count":3}]},{"hash":"1151272756152619495","title":"Cardiac neural crest and neural development","description":"The cluster centers on neural crest\u2013related development affecting heart and brain lineages: cardiac neural crest migration and right ventricle formation, outflow tract morphogenesis, as well as cranial neural/brain differentiation (branchiomeric muscle development, oligodendrocyte fate, vestibular nucleus and subpallial neuron timing). This pattern indicates a shared developmental program governing neural crest\u2013driven cardiac and neural lineage specification.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006366","count":7},{"id":"GO:0003253","count":6},{"id":"GO:0014707","count":6},{"id":"GO:0021750","count":6},{"id":"GO:0090128","count":6}]},{"hash":"213649899424512273","title":"ER targeting and ubiquitin-mediated degradation","description":"Top GO terms are dominated by SRP-dependent cotranslational protein targeting to the ER membrane and ubiquitin-dependent processes (ERAD, K11-linked ubiquitination, ubiquitin-dependent catabolic process). This points to a common role in directing nascent polypeptides to the endoplasmic reticulum and tagging misfolded or regulated proteins for degradation. Other terms (cell division, interferon response, snoRNP assembly, RNA Pol III transcription) are present but represented by single entries and likely reflect secondary associations or broad annotations rather than a unifying function of the cluster.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0006616","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0070979","count":1},{"id":"GO:0071357","count":1}]},{"hash":"2173440745954836572","title":"Cellular stress response and protein maturation","description":"The cluster combines stress-related GO terms (response to arsenic-containing substance, response to heat) with protein handling and maturation processes (peptidyl-tyrosine phosphorylation, obsolete chaperone-mediated folding, ER membrane targeting) and supportive metabolic activities (glutamine metabolism, iron-sulfur cluster assembly, cobalamin biosynthesis) along with cell cycle and signaling elements. This suggests a theme centered on maintaining protein quality and function under stress, with ancillary metabolic and regulatory processes. ","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":2,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0006541","count":6},{"id":"GO:0046685","count":4},{"id":"GO:0007049","count":3},{"id":"GO:0018108","count":3},{"id":"GO:1990507","count":3}]},{"hash":"1353237826870494870","title":"Mitotic spindle assembly and microtubule polarity","description":"Top GO terms point to microtubule dynamics, spindle organization, and polarity maintenance, including spindle assembly, end-directed microtubule activities, and vesicle transport along microtubules, with additional hints of neuronal structural maintenance. This suggests a cluster of proteins involved in microtubule-based organization during cell division and in maintaining cytoskeletal structure in neurons. ","confidence":"High","size":7,"edges":20,"triangles":30,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0090307","count":6},{"id":"GO:1990942","count":5},{"id":"GO:0045218","count":5},{"id":"GO:0031534","count":5},{"id":"GO:1990535","count":5}]},{"hash":"2222134845277816705","title":"ECM Remodeling and Adhesion","description":"The terms cluster around extracellular matrix (ECM) dynamics: hyaluronan metabolism, negative regulation of ECM assembly, metallopeptidase activity, and integrin signaling, all key to ECM remodeling and cell-ECM interactions. Additional terms point to connective tissue development (growth plate chondrocyte morphogenesis) and cell movement (extravasation), reinforcing a theme of ECM organization and tissue integrity, with related processes like coagulation and immune cell signaling as supporting context. Overall, a connective-tissue/ECM remodeling interpretation best fits the set.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003429","count":2},{"id":"GO:0045123","count":2},{"id":"GO:0030212","count":2},{"id":"GO:1901202","count":2},{"id":"GO:0070208","count":2}]},{"hash":"1243800308847643242","title":"MAPK-driven stress signaling and morphogenesis","description":"The GO terms cluster around signaling and stress responses: cellular responses to glucose and prostaglandin stimuli, Sho1 osmosensory signaling, and the cell integrity MAPK cascade, with related regulation of apoptosis and budding/matrix adhesion. Developmental terms like vagina development and metabolic notes like cholesterol biosynthesis are present but less central. The common thread appears to be MAPK- and signaling-mediated adaptation with developmental/morphogenetic associations, giving a plausible, moderate-confidence label.","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071333","count":7},{"id":"GO:0001954","count":7},{"id":"GO:0002688","count":7},{"id":"GO:0000196","count":7},{"id":"GO:0060068","count":7}]},{"hash":"159198157193346898","title":"Central metabolism and quinone biosynthesis","description":"This cluster\u2019s top GO terms center on core energy metabolism: glycolytic and TCA cycle activities, fatty acid \u03b2-oxidation, and various catabolic processes, along with biosynthesis of quinones (menaquinone, phylloquinone). There is an antibiotic biosynthetic term and one apoptotic regulation term, but the dominant signal is metabolic energy production and redox chemistry, linked by quinone biosynthesis. Therefore, the label Central metabolism with quinone biosynthesis captures the main functional theme.","confidence":"Medium","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0006099","count":3},{"id":"GO:0055114","count":3},{"id":"GO:0006096","count":2},{"id":"GO:0009234","count":2},{"id":"GO:0042372","count":2}]},{"hash":"782546946312953104","title":"Unknown","description":"TheTop terms span several unrelated processes (intracellular transport and unfolded protein response; photoreceptor outer segment localization; cell division and centrosome maintenance) plus odd items like plant hormone signaling and obsolete annotations. This dispersion suggests there is no single cohesive function tying these proteins together.","confidence":"","size":7,"edges":7,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":2},{"id":"GO:0008653","count":2},{"id":"GO:0006986","count":2},{"id":"GO:1903546","count":2},{"id":"GO:0051301","count":2}]},{"hash":"1133124197179774296","title":"Translation and SRP-dependent membrane targeting","description":"The top terms cluster around translation processes (prolyl-tRNA charging, translation, regulation of translational fidelity, and negative regulation of elongation) and SRP-dependent cotranslational targeting to membranes, indicating a group of proteins involved in protein synthesis and ER/membrane targeting. A few unrelated single-term annotations (JNK signaling, B cell apoptosis, cardiac action potential, chemokine regulation) do not define the cluster. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006433","count":1},{"id":"GO:0006450","count":1},{"id":"GO:0006412","count":1},{"id":"GO:0045900","count":1},{"id":"GO:0006614","count":1}]},{"hash":"2167625023130977067","title":"Unknown","description":"The top terms come from very diverse processes (plant brassinosteroid/homeostasis, metal ion response, vitamin D metabolism, muscle differentiation, xenobiotic/dioxin catabolism, alkaloid metabolism, oxidative demethylation, and immune cell regulation) with no single cohesive theme, so there isn\u2019t a meaningful, specific label beyond Unknown.","confidence":"","size":7,"edges":7,"triangles":1,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0010268","count":2},{"id":"GO:0071280","count":2},{"id":"GO:0036378","count":2},{"id":"GO:2001037","count":2},{"id":"GO:0019341","count":2}]},{"hash":"112109502251735403","title":"Carnitine Transport and Metabolism","description":"The top GO terms cluster around carnitine-related biology: transmembrane transport of (R)-carnitine, carnitine metabolic process, and brown fat cell differentiation, all pointing to adipocyte energy metabolism centered on carnitine. Other terms appear unrelated (e.g., pollen sperm differentiation, DNA integration), suggesting they are noisy annotations; the dominant theme remains carnitine transport/metabolism.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1900751","count":1},{"id":"GO:0040015","count":1},{"id":"GO:0050873","count":1},{"id":"GO:1902270","count":1},{"id":"GO:0048235","count":1}]},{"hash":"747188968279022904","title":"Redox homeostasis and oxidative stress response","description":"The dominant GO terms point to cellular redox balance, oxidative stress response, and oxidant detoxification, suggesting this cluster centers on managing reactive species. Some terms involve transcription regulation and ER stress, indicating broader stress-response connections, but the core theme remains redox biology.","confidence":"Medium","size":7,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0045454","count":2},{"id":"GO:0006351","count":2},{"id":"GO:0055114","count":2},{"id":"GO:0034599","count":1},{"id":"GO:0000122","count":1}]},{"hash":"1561506584190507421","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0006986","count":1},{"id":"GO:0046825","count":1},{"id":"GO:0071630","count":1}]},{"hash":"1928413893714856868","title":"Unknown","description":"The terms are a mix of thyroid hormone metabolism (generation, biosynthesis, catabolic) and unrelated development/signaling processes, with no connections among the proteins (Edges: 0). There is no single cohesive function tying the cluster together, so the label Unknown with no confidence. ","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006590","count":1},{"id":"GO:0061074","count":1},{"id":"GO:0042446","count":1},{"id":"GO:0042404","count":1},{"id":"GO:0032728","count":1}]},{"hash":"111095561880610522","title":"Chromatin organization and nucleosome assembly","description":"The cluster is dominated by GO terms tied to chromatin biology (nucleosome assembly, heterochromatin organization, chromatin localization), suggesting a coherent role in chromatin structure and nucleosome dynamics, despite a few unrelated terms.","confidence":"High","size":7,"edges":21,"triangles":35,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0016584","count":6},{"id":"GO:0071169","count":6},{"id":"GO:0097298","count":6},{"id":"GO:0080182","count":6},{"id":"GO:0006334","count":6}]},{"hash":"2226431254939753794","title":"Isoprenoid Lipid Biosynthesis and ER Trafficking","description":"The proteins cluster around terpenoid/isoprenoid biosynthesis (geranyl, farnesyl, geranylgeranyl diphosphate, monoterpenes, cholesterol, quinones), plus endoplasmic reticulum\u2013related processes (ER membrane fusion, vesicle fusion with ER, and protein transport). This combination points to a functional theme of isoprenoid lipid production and ER-associated trafficking.","confidence":"High","size":7,"edges":7,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0051290","count":1},{"id":"GO:0033384","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0006695","count":1},{"id":"GO:1901663","count":1}]},{"hash":"1857115742961964743","title":"Unknown","description":"The terms show a highly heterogeneous mix: skeletal system development, ribosome biogenesis, cell division, cell fusion, various signaling and immune-associated processes, and reproductive development. There isn't a single coherent biological function linking these proteins; with no edges and mixed GO terms, a concise, representative function label cannot be established.","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001501","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0000747","count":2},{"id":"GO:0060733","count":2}]},{"hash":"674716704277888391","title":"Ubiquitin-Proteasome-Mediated Protein Degradation","description":"This cluster is dominated by GO terms related to ubiquitin-dependent protein catabolic processes, polyubiquitination, and SCF-dependent proteasomal degradation, pointing to a core role in targeted protein turnover. Additional terms touch on cell cycle and developmental regulation, which are often controlled by ubiquitin ligases, reinforcing the central theme of proteostasis via the ubiquitin\u2013proteasome system.","confidence":"High","size":7,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0070544","count":4},{"id":"GO:0021993","count":4},{"id":"GO:0031146","count":4},{"id":"GO:0051436","count":4}]},{"hash":"569106746180470673","title":"Golgi vesicle trafficking and organization","description":"Proteins in this cluster are enriched for GO terms related to Golgi apparatus trafficking and organization, including ER-to-Golgi and intra-Golgi vesicle transport, Golgi ribbon formation, and vesicle fusion with the Golgi. While there are a few peripheral terms touching on immune signaling or synaptic functions, the dominant pattern is continuous Golgi- and vesicle-transport processes, suggesting these proteins work together in Golgi trafficking and organization.","confidence":"High","size":7,"edges":8,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0006891","count":2},{"id":"GO:0090161","count":2},{"id":"GO:0006896","count":2},{"id":"GO:0048280","count":2}]},{"hash":"2166366198396080704","title":"Growth-factor signaling in vascular and neural development","description":"This cluster is dominated by GO terms for hepatocyte growth factor receptor signaling (MET) and VEGF/neuropilin signaling, both central to angiogenesis and axon guidance. Terms like angiogenesis in coronary vascular morphogenesis, retina layer formation, and sensory neuron axon guidance point to coordinated vascular and neural development, with additional terms (platelet activation, complement regulation, carbohydrate metabolism) likely reflecting broader cellular context. Overall, the core theme fits growth-factor\u2013mediated development of blood vessels and neural/retinal structures.","confidence":"Medium","size":7,"edges":3,"triangles":0,"max_degree":3,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048012","count":3},{"id":"GO:0001868","count":3},{"id":"GO:1902378","count":3},{"id":"GO:0005975","count":3},{"id":"GO:0048842","count":3}]},{"hash":"245496443593876503","title":"Angiogenesis and immune signaling","description":"The top GO terms cluster around angiogenesis and endothelial cell migration, reinforced by ERK/MAPK signaling via receptor tyrosine kinases, and linked immune/hemostatic activities (adaptive immune response, platelets, lectin complement). This pattern suggests a vascular remodeling program coordinated with immune activation.","confidence":"High","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0070374","count":5},{"id":"GO:0002250","count":5},{"id":"GO:0043536","count":5},{"id":"GO:0001525","count":5},{"id":"GO:0007171","count":5}]},{"hash":"227709551209219189","title":"Unknown","description":"The GO terms cover diverse processes from skin development and bone resorption to dopamine uptake, vesicle trafficking, copper homeostasis, phosphorylation signaling, immune cell aggregation, oligodendrocyte differentiation, lysosomal organization, and modulation of synaptic activity, with no single overarching function linking them all. This lack of a coherent shared theme suggests no reliable cluster function to label.","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0060789","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0051586","count":1},{"id":"GO:0048194","count":1},{"id":"GO:0006878","count":1}]},{"hash":"158484161697779402","title":"Vascular and lymphatic development with immune signaling","description":"The included GO terms point to vessel and basement membrane development, lymphangiogenesis, VEGF and Notch pathway regulation, and some immune/modulatory roles (complement activation). Together they suggest a cluster of proteins involved in tissue morphogenesis that coordinates vascular/lymphatic growth with immune signaling and cell adhesion, rather than a single isolated function.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001867","count":2},{"id":"GO:1901492","count":2},{"id":"GO:0032836","count":2},{"id":"GO:0030913","count":2},{"id":"GO:0045747","count":2}]},{"hash":"1200737719816048014","title":"Cardiac action potentials and ion transport","description":"This cluster is dominated by GO terms related to cardiac electrophysiology: atrial and AV nodal action potentials, membrane depolarization, and potassium ion transport, plus vasoconstriction. While a few terms touch on temperature or pain, the strongest and most consistent signal is cardiac ion channel function and electrical activity.","confidence":"High","size":7,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0019233","count":5},{"id":"GO:0002024","count":5},{"id":"GO:0071502","count":5},{"id":"GO:0098914","count":4},{"id":"GO:0071805","count":4}]},{"hash":"2088491518279859198","title":"Motile cilium assembly and movement","description":"The GO terms show a coherent theme around ciliogenesis and ciliary motility (motile cilium assembly, axoneme assembly, cilium movement). Other terms like floral meristem growth, stomatal morphogenesis, and general endocytosis/iron transport appear ancillary or cross-species, but they do not override the clear ciliogenesis signal from the top terms. Therefore the cluster is best described as related to cilium assembly and movement.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044458","count":1},{"id":"GO:0035082","count":1},{"id":"GO:0060294","count":1},{"id":"GO:0010080","count":1},{"id":"GO:0030316","count":1}]},{"hash":"2115558292240423273","title":"Developmental growth and tissue differentiation","description":"The cluster includes GO terms focused on development and differentiation, notably positive regulation of cell growth, heart left/right asymmetry determination, skin and epidermal development, epidermal cell division, and neuron migration, suggesting a developmental/tissue-differentiation theme. Some terms (Golgi localization, membrane depolarization) are less central to this theme, so the label reflects the core developmental signals with moderate confidence.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030307","count":2},{"id":"GO:0061371","count":2},{"id":"GO:0006713","count":1},{"id":"GO:0043588","count":1},{"id":"GO:0043154","count":1}]},{"hash":"750058426597912388","title":"Cofactor metabolism and redox stress response","description":"The terms cluster around biosynthesis and catabolism of cofactors (CoA/pantothenate) and glutathione, plus redox-related stress responses (UV, antibiotic) and redox homeostasis. This suggests a theme of managing cofactors and maintaining redox balance, with a few terms (sporulation, epithelial differentiation) likely reflecting broader protein multifunctionality.","confidence":"Medium","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:1901285","count":1},{"id":"GO:0015937","count":1},{"id":"GO:0030435","count":1},{"id":"GO:0015941","count":1},{"id":"GO:0006749","count":1}]},{"hash":"897687398855140467","title":"RNA and protein methylation","description":"This cluster is dominated by GO terms for methylation events: tRNA methylation, rRNA modification, N-terminal methylation of peptides, and mRNA 7-methylguanosine capping, plus histone methylation. These point to a set of methyltransferases acting on RNA and protein substrates. Some terms (nodulation, antibiotic biosynthesis, selenium metabolism) are less connected, but the core signal is methylation-related processes.","confidence":"Medium","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":2},{"id":"GO:0018012","count":2},{"id":"GO:0000154","count":2},{"id":"GO:0009877","count":2},{"id":"GO:0009236","count":2}]},{"hash":"2094533981254693427","title":"Dopamine Receptor Signaling","description":"The top GO terms cluster around dopamine receptor signaling, dopamine uptake regulation, and related neuromodulatory processes, with supporting signals for GTPase regulation, astrocyte chemotaxis, and peptide responses. This points to a coherent theme of dopaminergic signaling and synaptic modulation across the proteins.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0007191","count":7},{"id":"GO:1900135","count":7},{"id":"GO:2000458","count":7},{"id":"GO:1901652","count":7},{"id":"GO:0018298","count":7}]},{"hash":"707993068594261697","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":6,"triangles":0,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0006986","count":1},{"id":"GO:0046825","count":1},{"id":"GO:0071630","count":1}]},{"hash":"1329450529155009498","title":"Vascular coagulation and fibrinolysis regulation","description":"The cluster\u2019s top GO terms cluster around hemostasis and vessel control: positive regulation of vasoconstriction, blood coagulation, plasminogen activation, and positive regulation of fibrinolysis. These point to a cohesive theme of vascular regulation and coagulation, with neural development terms present as likely secondary or pleiotropic functions of shared proteins. ","confidence":"Medium","size":7,"edges":4,"triangles":0,"max_degree":3,"top_function":"inflammatory response","top_go_terms":[{"id":"GO:0045907","count":5},{"id":"GO:0007596","count":5},{"id":"GO:0051968","count":5},{"id":"GO:0031639","count":5},{"id":"GO:0051919","count":5}]},{"hash":"332393680164149048","title":"NF-kB/MAPK Immune and Epithelial Signaling","description":"Top terms reveal immune signaling (T cell homeostasis, NF-kappaB activation) intertwined with epithelial differentiation (polarized epithelia, lens morphogenesis) and stress-responsive signaling (MAPK, calcium entry, osmosensing, ubiquitination). This suggests a theme of NF-kB/MAPK-driven signaling networks that regulate immune function, epithelial development, and cellular stress responses.","confidence":"Medium","size":7,"edges":7,"triangles":1,"max_degree":6,"top_function":null,"top_go_terms":[{"id":"GO:0043029","count":2},{"id":"GO:0030859","count":1},{"id":"GO:0070309","count":1},{"id":"GO:0097039","count":1},{"id":"GO:0050894","count":1}]},{"hash":"1516146633376783477","title":"Unknown","description":"Unknown","confidence":"","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0006458","count":1},{"id":"GO:0006986","count":1},{"id":"GO:0046825","count":1},{"id":"GO:0071630","count":1}]},{"hash":"588668035112859238","title":"Vesicle Trafficking and Immune Antigen Presentation","description":"The proteins cluster around intracellular and vesicle-mediated transport (ER-Golgi, endosome, clathrin-coated vesicles, synaptic vesicles) and also connect to immune functions (NK cell degranulation, NK T cell differentiation, and antigen processing/presentation via MHC Ib), indicating a cohesive role in vesicle trafficking that supports immune signaling and antigen presentation.","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006886","count":1},{"id":"GO:0043323","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0048007","count":1},{"id":"GO:0035646","count":1}]},{"hash":"1907321863022572393","title":"Spliceosome and RNA Processing","description":"Based on the predominance of RNA splicing and processing terms (mRNA cis splicing via spliceosome, mRNA processing, RNA splicing, spliceosomal tri-snRNP complex assembly), this cluster appears to reflect components of the spliceosome and RNA processing machinery. The additional terms for development and DNA repair likely represent broader or overlapping annotations, but the core signal is RNA splicing. ","confidence":"High","size":7,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045292","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0008380","count":1},{"id":"GO:0000244","count":1},{"id":"GO:0021536","count":1}]},{"hash":"1117691350549267141","title":"Cardiac muscle and vascular development","description":"The cluster shows strong enrichment for cardiac muscle development and contraction terms (cardiac muscle tissue development, heart contraction, cardiac muscle cell development, muscle organ development) as well as vasculogenesis-related terms (positive regulation of vasculogenesis, vascular associated smooth muscle cell development). A related but broader muscle-development signal is also present (muscle cell development, myoblast differentiation). The swim bladder inflation term is an outlier but aligns with organ muscle\u2013related development in some species, leaving the cardiac/muscular-vascular theme as the core signal.","confidence":"High","size":7,"edges":7,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0048738","count":1},{"id":"GO:0060047","count":1},{"id":"GO:0097084","count":1},{"id":"GO:0055013","count":1},{"id":"GO:0048747","count":1}]},{"hash":"1707664166535366348","title":"Unknown","description":"The top terms span visual perception, plant ABA signaling, synaptic potentiation, Schwann cell development, cell-cycle transitions, heart development, apoptosis, and phosphorylation regulation, with no single shared function apparent. The lack of connecting edges also suggests a heterogeneous set rather than a cohesive cluster, so no specific functional label is supported.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":3},{"id":"GO:0009738","count":3},{"id":"GO:0060291","count":3},{"id":"GO:0014044","count":3},{"id":"GO:0000086","count":3}]},{"hash":"365833861736095554","title":"Ubiquitin-dependent turnover and MAPK signaling","description":"Proteins in this cluster are enriched for ubiquitin-related processes (ubiquitin-dependent protein catabolic process, autoubiquitination, monoubiquitination), as well as regulation of signaling cascades (regulation of JNK cascade, negative regulation of ERK1/2 cascade, positive regulation of GTPase activity) and ubiquitin-dependent endocytosis, with an additional hint of synapse organization. This suggests a coherent theme: ubiquitin-mediated protein turnover and trafficking modulate MAPK signaling and related pathways, potentially impacting synaptic regulation. Therefore, the label captures the core shared function of the cluster.","confidence":"High","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0046328","count":4},{"id":"GO:0070373","count":3},{"id":"GO:0006513","count":3}]},{"hash":"1343369685591667336","title":"RNA processing and export","description":"This cluster is dominated by GO terms tied to mRNA processing and handling in the nucleus: splicing via the spliceosome, mRNA export, stabilization, and regulation of mRNA stability and poly(A) tail dynamics, with an additional note of subunit processome assembly (ribosomal RNA processing) that still reflects RNA maturation pathways. Together these indicate a cohesive role in RNA maturation and export rather to broader signaling pathways.","confidence":"High","size":6,"edges":14,"triangles":16,"max_degree":5,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0045292","count":4},{"id":"GO:0010610","count":4},{"id":"GO:1902625","count":3},{"id":"GO:0034462","count":3},{"id":"GO:1901407","count":3}]},{"hash":"1718947798099191495","title":"One-Carbon and Folate Metabolism","description":"The cluster is dominated by GO terms tied to folate and one-carbon metabolism (tetrahydrofolate/dihydrofolate/dTMP biosynthesis, folic acid metabolism, and one-carbon metabolic process) and glycine biosynthesis, all of which are interconnected in nucleotide synthesis and one-carbon donor cycles. While there are a couple of auxiliary terms (antibiotic response, superoxide regulation), the core theme centers on folate-mediated one-carbon metabolism and related nucleotide biosynthesis. High","confidence":"","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0006729","count":2},{"id":"GO:0006545","count":2},{"id":"GO:0006231","count":2},{"id":"GO:0046677","count":2},{"id":"GO:0046654","count":2}]},{"hash":"2118574946196853832","title":"Ubiquitin-Driven Degradation and Innate Immunity","description":"The top GO terms center on ubiquitination and proteolysis (e.g., protein ubiquitination, ubiquitin-dependent protein catabolic process, K63-linked ubiquitination) alongside innate immune signaling (innate immune response, activation of NF-kappaB-inducing kinase). This points to a theme of ubiquitin-mediated protein turnover connected to immune pathway activation, with a few related trafficking or degradation processes as broader context. Confidence: Medium","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0001896","count":1},{"id":"GO:0097039","count":1},{"id":"GO:0050999","count":1},{"id":"GO:0007250","count":1},{"id":"GO:0038018","count":1}]},{"hash":"2255286077253019164","title":"Ribosome Biogenesis & Translation","description":"The top GO terms cluster around ribosome biogenesis (ribosome assembly and nuclear export), cytoplasmic translation, and tRNA modification, indicating a core theme of ribosome production and protein synthesis. There are also terms related to cell division/cell cycle, which can co-occur in proliferative states, and a couple of development annotations that may reflect broader gene functions. Overall, the dominant signal ties to ribosome assembly and the machinery of translation.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":2},{"id":"GO:0000055","count":2},{"id":"GO:0007507","count":2},{"id":"GO:0002181","count":1},{"id":"GO:1903833","count":1}]},{"hash":"2055879129619483423","title":"Synaptic Plasticity and Muscle Signaling Regulators","description":"Top GO terms indicate involvement in extracellular matrix organization, transcription regulation, miRNA processing, long-term potentiation, postsynaptic calcium signaling, and muscle-related processes like skeletal muscle differentiation and heart contraction, plus regulatory mechanisms like protein methylation and GTPase activity. The cluster therefore appears to group proteins that modulate signaling and gene expression in neural and muscular contexts, particularly synaptic plasticity and calcium-dependent signaling, with some ECM and hormonal regulation. This supports a cohesive theme of neural\u2013muscle signaling regulation.","confidence":"Medium","size":6,"edges":10,"triangles":7,"max_degree":4,"top_function":"extracellular matrix organization","top_go_terms":[{"id":"GO:0030198","count":3},{"id":"GO:0045944","count":2},{"id":"GO:1903799","count":2},{"id":"GO:1900271","count":2},{"id":"GO:2001015","count":2}]},{"hash":"116718579457444003","title":"Cartilage ECM remodeling and adhesion signaling","description":"The top GO terms cluster around cartilage development (growth plate chondrocyte morphogenesis), hyaluronan metabolism, and regulation of extracellular matrix assembly, plus integrin-mediated signaling and metallopeptidase activity, pointing to extracellular matrix remodeling in cartilage and cell-ECM adhesion pathways. Some terms like T cell activation and coagulation appear, but the dominant pattern supports cartilage ECM remodeling and adhesion signaling.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003429","count":3},{"id":"GO:0045123","count":3},{"id":"GO:0030212","count":3},{"id":"GO:1901202","count":3},{"id":"GO:0070208","count":3}]},{"hash":"1202744464489409291","title":"Actin dynamics and cell migration","description":"These proteins are enriched for terms tied to actin cytoskeleton remodeling and cell movement: Arp2/3-mediated actin nucleation, actin cortical patch assembly, regulation of endocytosis, mesenchyme migration, and skeletal muscle fiber adaptation. The mitochondrion localization term suggests trafficking along the cytoskeleton, supporting a motility/cytoskeletal theme. A couple of terms (subtelomeric heterochromatin formation, inter-male aggressive behavior) are less clearly connected and may reflect distant functional links or noise.","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0009825","count":5},{"id":"GO:0030100","count":5},{"id":"GO:0043503","count":5},{"id":"GO:0090131","count":5},{"id":"GO:0000147","count":5}]},{"hash":"883941915143902344","title":"Cellular maintenance and stress responses","description":"The terms point to basic housekeeping processes (mitochondrial dynamics, mitophagy, protein translation/export, Golgi retention) along with cell cycle and broad stress/immune responses (interferon signaling and defense against bacteria). This suggests a general theme of cellular maintenance and responses to stress rather than a single specific pathway.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010636","count":1},{"id":"GO:0045053","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000055","count":1}]},{"hash":"236171167317162338","title":"Lipid biosynthesis and sterol metabolism","description":"The Top Terms converge on lipid pathways: unsaturated fatty acid biosynthesis, sphingosine biosynthesis, ergosterol/sterol metabolism, and cholesterol esterification regulation, plus related lipid processes like MIPC metabolism and myelin/sebaceous-associated lipid maintenance. While a few terms are peripheral, the central theme is lipid and sterol biosynthesis and homeostasis across eukaryotes, supporting this label.","confidence":"Medium","size":6,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":5},{"id":"GO:0032286","count":5},{"id":"GO:0001949","count":5},{"id":"GO:0006675","count":5},{"id":"GO:0000001","count":5}]},{"hash":"2293270349829193185","title":"Carbohydrate Biosynthesis and Osmotic Stress Response","description":"This cluster centers on carbohydrate metabolism (glycogen, starch, sucrose, glycolipid, bacillithiol biosynthesis) and osmotic stress-related responses (flooding, sorbitol, sucrose). The combination suggests proteins involved in sugar biosynthesis and osmotic adjustment rather than a single narrowly defined pathway, justifying a label focused on carbohydrate biosynthesis with osmotic stress responsiveness.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0005978","count":3},{"id":"GO:0009413","count":2},{"id":"GO:0009247","count":2},{"id":"GO:0072708","count":2},{"id":"GO:0071793","count":2}]},{"hash":"639489944745710929","title":"Diverse Metabolite Biosynthesis","description":"The top GO terms point to a range of biosynthetic processes (retinol, estrogen, glucocorticoid, melanin, very long-chain fatty acids, antibiotics, tetrahydrobiopterin, poly-hydroxybutyrate), suggesting a general theme of metabolite and small-molecule biosynthesis rather than a single pathway. The lack of explicit interactions (Edges 0) fits a cluster annotated with diverse biosynthetic activities rather than a specific complex, so a broad biosynthesis label best captures the common function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":4},{"id":"GO:0042619","count":3},{"id":"GO:0042572","count":2},{"id":"GO:0006704","count":2},{"id":"GO:0046677","count":2}]},{"hash":"1587726091970435730","title":"Mitochondrial lipid remodeling and energy production","description":"Top terms cluster around mitochondrial lipid remodeling (cardiolipin, phosphatidylcholine, ether lipids) and lipid biosynthesis (CDP-diacylglycerol) together with mitochondrial ATP synthesis, indicating a cohesive theme of mitochondrial lipid metabolism supporting energy production.","confidence":"High","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0021587","count":4},{"id":"GO:2001246","count":4},{"id":"GO:0070236","count":4},{"id":"GO:0035965","count":4},{"id":"GO:0042775","count":4}]},{"hash":"21272080147816743","title":"GPCR Signaling and Phototransduction","description":"The dominant GO terms point to GTPase activity regulation and signaling via G protein-coupled receptors, including dopamine and adrenergic receptor pathways, with downstream effects on adenylate cyclase and phospholipase C, as well as phototransduction. This suggests a cohesive theme of GPCR-driven signaling with cAMP/PI pathways and sensory signal processing, though a few terms related to development or plant signaling may reflect broader roles or cross-ontology noise. ","confidence":"Medium","size":6,"edges":15,"triangles":20,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":5},{"id":"GO:0007507","count":5},{"id":"GO:0007191","count":4},{"id":"GO:0071880","count":4},{"id":"GO:0007603","count":4}]},{"hash":"1259815373292438039","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051384","count":1},{"id":"GO:0034354","count":1},{"id":"GO:0043420","count":1},{"id":"GO:0007219","count":1},{"id":"GO:0019442","count":1}]},{"hash":"1404441537363212993","title":"RNA methylation and mitochondrial transcription regulation","description":"The cluster\u2019s top terms cluster around RNA modification (tRNA/rRNA methylation, protein methylation) and mitochondrial gene expression control (regulation and initiation of transcription at mitochondrial promoters, SSU-rRNA maturation). While some links to broader transcription by RNA Pol II and a glucose-response signal exist, the strongest shared theme is RNA modification together with mitochondrial transcription regulation, justifying a concise label that highlights these connected processes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030488","count":1},{"id":"GO:0031167","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0006479","count":1},{"id":"GO:1903108","count":1}]},{"hash":"967342528160593379","title":"Nucleotide metabolism and RNA editing","description":"The set includes several nucleotide metabolism processes (UMP salvage, cytosine/cytidine/uridine metabolism, deoxycytidine catabolism, guanine catabolic, uridine biosynthesis) and a tRNA wobble adenosine to inosine editing, indicating a common theme around nucleotide metabolism and RNA modification. Some terms like riboflavin biosynthesis, nuclear envelope organization, and response to antibiotic appear less directly connected, but the dominant signal is nucleotide metabolism.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006217","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0044206","count":1},{"id":"GO:0019858","count":1},{"id":"GO:0002100","count":1}]},{"hash":"1762571734581340459","title":"Ribosome Biogenesis and rRNA Processing","description":"The proteins are dominated by GO terms for maturation and processing of rRNA (SSU and LSU, including 5.8S), ribosomal large subunit biogenesis, and nucleolus organization, pointing to a cohesive role in ribosome assembly within the nucleolus. A few terms like cell cycle DNA replication and defense response to virus appear but do not define the core function of the cluster.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":1},{"id":"GO:0007000","count":1},{"id":"GO:0042273","count":1},{"id":"GO:0000462","count":1},{"id":"GO:0042254","count":1}]},{"hash":"841019709418408442","title":"Vesicle trafficking and synaptic exocytosis","description":"The top GO terms point to Golgi-to-plasma membrane transport, Golgi vesicle budding, and especially regulation of synaptic vesicle exocytosis and dopamine uptake, together with brain development. This suggests a shared function in neuronal vesicle trafficking and secretion, guiding cargo to the plasma membrane and supporting synaptic transmission. Some terms (hair follicle placode formation, bone resorption) are less connected and may reflect broader annotations, but the dominant theme is vesicle transport in neurons.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043001","count":2},{"id":"GO:0031384","count":2},{"id":"GO:0007420","count":2},{"id":"GO:2000300","count":2},{"id":"GO:0010796","count":2}]},{"hash":"1128371219659971138","title":"Meiosis: synaptonemal complex and DNA damage response","description":"The terms point to meiotic chromosome pairing (synaptonemal complex assembly, microsporogenesis) and genome maintenance (DNA damage response, mitotic DNA integrity checkpoint signaling), with ubiquitin-mediated proteolysis supporting regulation. A few unrelated terms (cadherin regulation) may reflect incidental annotations, but the core theme is meiotic chromosome dynamics and DNA damage checkpoints.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051301","count":1},{"id":"GO:0007130","count":1},{"id":"GO:0010944","count":1},{"id":"GO:0044774","count":1},{"id":"GO:0051312","count":1}]},{"hash":"1730679119946547698","title":"Ubiquitin-dependent antiviral signaling","description":"This cluster centers on ubiquitin-mediated processes (ubiquitin-dependent protein catabolic process, autoubiquitination, K63-linked ubiquitination, ERAD) and innate immune/ antiviral responses (innate immune response, defense response to virus) including NF-\u03baB pathway activation, suggesting a cohesive role in tagging proteins for turnover while modulating antiviral signaling.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:0042787","count":5},{"id":"GO:0051865","count":4},{"id":"GO:0045087","count":4},{"id":"GO:0051607","count":4},{"id":"GO:0030433","count":4}]},{"hash":"1884018964951041139","title":"Signaling and cytoskeletal regulation","description":"The cluster features GO terms focused on signaling pathways (JUN phosphorylation; insulin receptor signaling; thrombin-activated receptor signaling; activation of GTPase activity; regulation of Rho signaling) and processes related to cytoskeletal dynamics and cell adhesion (positive regulation of substrate adhesion-dependent cell spreading; Rho signaling). These together point to a shared function in transducing signals that control adhesion, cytoskeleton remodeling, and cell motility, with a few terms touching development or immune signaling that are less central to the core theme.","confidence":"Medium","size":6,"edges":5,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0007258","count":2},{"id":"GO:0043314","count":2},{"id":"GO:1900026","count":2},{"id":"GO:1904693","count":2},{"id":"GO:0060313","count":2}]},{"hash":"923820937845152730","title":"TLR9-driven antibacterial defense and cytokine regulation","description":"This cluster centers on innate immune signaling and antibacterial responses, highlighted by TLR9 signaling, detection of diacyl lipopeptides, defense against Gram-negative bacteria, and regulation of cytokines like IL-6, IL-12, and IL-17, with links to endosomal signaling and barrier-related responses.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032700","count":1},{"id":"GO:0046330","count":1},{"id":"GO:0034162","count":1},{"id":"GO:0050829","count":1},{"id":"GO:0045410","count":1}]},{"hash":"1606803355491563991","title":"Golgi\u2013endosome vesicle trafficking","description":"These proteins predominantly map to vesicle transport within the endomembrane system, including ER-to-Golgi, endosome-to-Golgi, intra-Golgi, and retrograde pathways, plus related secretory processes such as neutrophil degranulation and autophagosome docking. The common thread is intracellular vesicle trafficking and secretion centered on the Golgi-endosome axis, justifying the name.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006888","count":2},{"id":"GO:0001501","count":1},{"id":"GO:0034498","count":1},{"id":"GO:0015031","count":1},{"id":"GO:0060291","count":1}]},{"hash":"975768221195374883","title":"Unknown","description":"The GO terms are scattered across development, neural signaling, vesicle trafficking, metal ion homeostasis, and immune cell interactions, with only single counts for each term. This lack of a unifying biological process makes it impossible to assign a meaningful, specific label to the cluster.","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0060789","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0051586","count":1},{"id":"GO:0048194","count":1},{"id":"GO:0006878","count":1}]},{"hash":"25815843171745740","title":"Lipid catabolism and membrane trafficking","description":"The top GO terms point to lipid breakdown (sphingomyelin and phosphatidylcholine catabolism) and receptor-mediated endocytosis, suggesting a shared theme of membrane lipid processing and uptake. Some terms about actin remodeling and differentiation appear but may reflect downstream or broader membrane dynamics rather than a single pathway. Overall, the cluster seems best described by lipid catabolism coupled with membrane trafficking processes.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0090305","count":4},{"id":"GO:0031953","count":4},{"id":"GO:0006685","count":4},{"id":"GO:0034638","count":4},{"id":"GO:0048714","count":4}]},{"hash":"371029754251676176","title":"Paranode and Juxtaparanode Axon Localization","description":"Most of the top GO terms map to assembly and localization at paranodal and juxtaparanodal regions of the axon, indicating proteins involved in organizing nodes of Ranvier and axon\u2013glia interfaces. Other terms (platelet activation, mitotic cell cycle, endoderm development, neural crest migration, HGF signaling) are represented sparsely and likely reflect broader or unrelated functions; the core signal is axonal paranodal organization.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030913","count":2},{"id":"GO:0071205","count":2},{"id":"GO:0030168","count":2},{"id":"GO:0002175","count":2},{"id":"GO:0000278","count":2}]},{"hash":"684356894180606741","title":"GPCR Signaling with GTPase Regulation","description":"The top GO terms cluster around GPCR signaling pathways (adenylate cyclase-activating and PLC-activating) and the regulation of GTPase/Rho activity, pointing to GPCR-driven signal transduction and downstream GTPase control as the core theme. Some terms about development and metabolism appear as broader context, but they do not override the central GPCR/GTPase link.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0008283","count":3},{"id":"GO:0060041","count":3},{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3}]},{"hash":"974015202024574712","title":"Regulation of synaptic transmission","description":"This cluster is dominated by GO terms related to neuronal signaling and synaptic regulation, including regulation of vesicle fusion at the presynaptic zone, short-term synaptic plasticity, and receptor clustering, indicating roles in modulating synaptic communication. Some metabolic/ion terms appear incidental to this core neuronal function.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045471","count":1},{"id":"GO:0031630","count":1},{"id":"GO:0048172","count":1},{"id":"GO:0018964","count":1},{"id":"GO:0071311","count":1}]},{"hash":"829423435902715140","title":"Unknown","description":"The top GO terms are highly diverse, spanning cellular signaling, immune defense, transcription, viral mRNA export, development, and stress responses, with no single cohesive function or pathway linking the proteins. The lack of edges and a unifying theme supports labeling this cluster as Unknown.","confidence":"","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0036120","count":3},{"id":"GO:0043029","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0050830","count":3},{"id":"GO:0046784","count":3}]},{"hash":"1803366716656682316","title":"Developmental signaling and tissue differentiation","description":"This cluster centers on signals governing tissue development, including skin and seminiferous tubule formation, and broader multicellular organism development. The presence of GO terms for positive regulation of GTPase activity and kinase/autophosphorylation suggests active signal transduction, while other terms point to post-transcriptional processes (mRNA transport) and cell cycle involvement, implying coordination between development and cellular proliferation. Overall, a coherent theme of developmental signaling in tissues, with some peripheral functions, supports this label.","confidence":"Medium","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":3},{"id":"GO:0043588","count":3},{"id":"GO:0007275","count":3},{"id":"GO:0072520","count":2},{"id":"GO:0051028","count":2}]},{"hash":"1749385412125754180","title":"Unknown","description":"Unknown","confidence":"","size":6,"edges":5,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0034402","count":1},{"id":"GO:0006397","count":1},{"id":"GO:0000288","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0006367","count":1}]},{"hash":"35825032463700557","title":"Nitrate uptake and metabolism with peptide transport","description":"This cluster is dominated by nitrate-related processes: nitrate assimilation (6), response to nitrate (4), and nitrate transmembrane transport (4). It also shows oligopeptide and dipeptide transport (4), indicating active amino acid transport alongside nitrogen metabolism. Additionally, there are hormone signaling terms (auxin-activated signaling and gibberellic acid homeostasis) suggesting a link between nitrogen status and growth regulation, with some broad ion transport. Overall, the core theme centers on nitrate uptake/metabolism and peptide transport, with supporting transport and growth-related signals.","confidence":"Medium","size":6,"edges":6,"triangles":1,"max_degree":5,"top_function":null,"top_go_terms":[{"id":"GO:0042128","count":6},{"id":"GO:0010167","count":4},{"id":"GO:0009734","count":4},{"id":"GO:0042938","count":4},{"id":"GO:0010336","count":4}]},{"hash":"59300951982528757","title":"Kinetochore-spindle assembly and chromosome alignment","description":"The dominant theme is mitosis: terms on spindle organization, kinetochore assembly and attachment, spindle checkpoint activation, and metaphase chromosome alignment. A couple terms related to epithelial differentiation and lens morphogenesis are present but are secondary to the core mitotic functions.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007052","count":1},{"id":"GO:0000132","count":1},{"id":"GO:1903394","count":1},{"id":"GO:0090268","count":1},{"id":"GO:0051315","count":1}]},{"hash":"1096615335318565560","title":"Embryonic morphogenesis and organ development","description":"The top GO terms point to embryonic development and diverse organ morphogenesis (brain, eye, digestive tract, kidney podocyte), plus neural connectivity (axon guidance/axonogenesis) and cell adhesion. This suggests a cohesive role in shaping tissues during development, with involvement of adhesion-mediated processes across multiple organs.","confidence":"High","size":6,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003412","count":1},{"id":"GO:0033564","count":1},{"id":"GO:0048854","count":1},{"id":"GO:0007502","count":1},{"id":"GO:0045995","count":1}]},{"hash":"348206947865970679","title":"Mitosis control and ubiquitin-mediated proteolysis","description":"The cluster centers on mitotic control and ubiquitin-regulated proteolysis. G2/M transition, exit from mitosis, and chromosome segregation are prominent, with SCF-dependent ubiquitin tagging and K63-linked ubiquitination tying proteolysis to mitotic progression. While a viral process and some peripheral terms appear, the dominant theme is cell cycle regulation through targeted protein degradation and signaling.","confidence":"High","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:0000086","count":5},{"id":"GO:0016032","count":5},{"id":"GO:0070911","count":5},{"id":"GO:0031146","count":5},{"id":"GO:0010458","count":5}]},{"hash":"89288258279728582","title":"Sterol and Lipid Biosynthesis","description":"The cluster is dominated by GO terms tied to lipid and sterol metabolism, including ether lipid metabolism, cholesterol biosynthesis via lathosterol, fatty acid biosynthesis, and ergosterol biosynthesis, plus sterol oxidation. The CNS myelin maintenance term also reflects lipid-rich myelin biology, supporting a unifying theme of lipid/sterol biosynthesis and processing. Some items (e.g., B cell chemotaxis, sebaceous gland differentiation) are tangentially related through broader lipid-related biology, but the core signal is lipid and sterol metabolism.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0046485","count":2},{"id":"GO:0032286","count":2},{"id":"GO:0033490","count":2},{"id":"GO:0006633","count":2},{"id":"GO:0006675","count":2}]},{"hash":"950335992927607587","title":"ERAD and Proteostasis in the ER","description":"This cluster highlights ubiquitin-dependent ER-associated degradation (ERAD), aggresome assembly, proteasomal regulation, and ER-related membrane protein handling (tail-anchored insertion) and deglycosylation, all pointing to protein quality control and proteostasis in the endoplasmic reticulum. A few terms about cell division or transcription appear less connected and may reflect annotation noise, but the dominant signal is ER-based proteolysis and quality control.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0070842","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071555","count":2},{"id":"GO:0006517","count":1}]},{"hash":"768757967089711142","title":"Ubiquitin-Proteasome Degradation","description":"The cluster is dominated by GO terms for ubiquitin-dependent protein degradation (SCF-dependent proteasomal ubiquitinylation and ERAD), indicating a cohesive function in marking proteins for destruction. A few meiotic progression terms and other roles (peroxisomal import, Wnt turnover, NF-\u03baB signaling) may reflect broader regulatory connections, but the central theme remains ubiquitin-proteasome\u2013mediated proteolysis.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031146","count":4},{"id":"GO:0042787","count":4},{"id":"GO:1902104","count":3},{"id":"GO:0051759","count":3},{"id":"GO:0030433","count":2}]},{"hash":"138049771771819999","title":"DNA damage response and repair","description":"The cluster is dominated by GO terms tied to DNA replication, DNA repair, DNA-templated transcription, and error-free translesion synthesis, plus a toxin-response term, which together point to genome integrity maintenance and DNA damage response. The presence of MAPK-related and cell signaling terms suggests downstream stress signaling that accompanies DNA damage repair processes. Overall, these proteins appear to functionally cluster around DNA damage sensing/repair pathways, with ancillary signaling roles.","confidence":"High","size":5,"edges":2,"triangles":0,"max_degree":1,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0006260","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0006351","count":3},{"id":"GO:0009636","count":3},{"id":"GO:0051260","count":2}]},{"hash":"1867801394412558283","title":"Ubiquitin-Dependent Innate Antiviral Signaling","description":"The cluster shows strong representation of ubiquitin-dependent protein degradation (ERAD, proteolysis) alongside innate immune pathways such as NF-kappaB activation, TNF signaling, JNK regulation, and defense against viruses, suggesting proteins involved in tagging and degrading factors to modulate antiviral signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":4},{"id":"GO:0007250","count":3},{"id":"GO:0038018","count":3},{"id":"GO:0042787","count":3},{"id":"GO:0045087","count":3}]},{"hash":"1847826768719196005","title":"Ossification and vasculature development","description":"The top GO terms cluster around bone formation signals (intramembranous ossification; BMP stimulus response) and vascular development/remodeling (glomerulus vasculature development; endothelial migration regulation; fibrinolysis). While a few terms touch on cell surface signaling, the dominant pattern points to skeletal ossification processes and related blood vessel formation and remodeling, suggesting these proteins contribute to bone formation and its vasculature context.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002752","count":1},{"id":"GO:0034394","count":1},{"id":"GO:0071773","count":1},{"id":"GO:0010519","count":1},{"id":"GO:0042730","count":1}]},{"hash":"103964126799403153","title":"Ribosome Biogenesis and Translation","description":"The cluster\u2019s top GO terms are dominated by ribosome-related processes: maturation of LSU-rRNA, ribosome biogenesis, cytoplasmic translation, and ribosomal large subunit export from the nucleus, indicating a core function in ribosome assembly and protein synthesis. While some plant-specific terms appear, they do not override the central ribosome-focused theme. Therefore, a label centered on ribosome biogenesis and translation best represents the cluster.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0000463","count":2},{"id":"GO:0042254","count":2},{"id":"GO:0002181","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000055","count":1}]},{"hash":"489649774774191134","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001209","count":1},{"id":"GO:0090262","count":1},{"id":"GO:0033696","count":1},{"id":"GO:0032968","count":1},{"id":"GO:2001173","count":1}]},{"hash":"691316835513847864","title":"Developmental signaling and synapse organization","description":"This cluster includes GO terms pointing to broad signaling regulation (negative regulation of TGF-beta production; IL-27 signaling; STAT phosphorylation) as well as neural connectivity (synapse organization; dendritic spine morphogenesis) and developmental processes (axial mesoderm formation; vagina development) plus adhesion processes. The mix suggests proteins involved in coordinating signaling pathways during development and synaptic maturation.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:2001202","count":5},{"id":"GO:0050925","count":5},{"id":"GO:0001954","count":5},{"id":"GO:0060068","count":5},{"id":"GO:0050808","count":5}]},{"hash":"1007658365543944489","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0031047","count":2},{"id":"GO:0045451","count":2},{"id":"GO:0048026","count":2},{"id":"GO:0060213","count":2},{"id":"GO:0031124","count":1}]},{"hash":"2212176105394403330","title":"Heat Shock and Nuclear Transport","description":"The GO terms point to heat-stress responses (e.g., mRNA export from the nucleus in response to heat stress) and nuclear trafficking/localization (nuclear inner membrane localization, nuclear import), suggesting a loose theme of heat-induced nuclear transport. However, with no edges and several obsolete terms, the connection is not tightly defined, so this label reflects a broad, high-level function rather than a specific module.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0035392","count":1},{"id":"GO:0035080","count":1},{"id":"GO:0043547","count":1},{"id":"GO:0031990","count":1},{"id":"GO:0036228","count":1}]},{"hash":"82717995512042800","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"DNA replication","top_go_terms":[{"id":"GO:0034476","count":3},{"id":"GO:0042766","count":3},{"id":"GO:1990416","count":3},{"id":"GO:0031047","count":3},{"id":"GO:1902775","count":3}]},{"hash":"858228428183251804","title":"Dendritic Spine Morphogenesis and Synaptic Signaling","description":"The dominant terms are about synapse biology: dendritic spine morphogenesis, receptor clustering, and protein localization to the synapse, plus Rho-mediated signal transduction that influences cytoskeletal remodeling needed for spine formation. This points to a module focused on synapse assembly/maintenance and related signaling pathways (e.g., JNK regulation). Some VEGF/prostaglandin and hematopoiesis terms may reflect broader signaling cross-talk but do not override the synaptic core.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0060997","count":5},{"id":"GO:0043113","count":5},{"id":"GO:0035418","count":5},{"id":"GO:0007266","count":5},{"id":"GO:0008285","count":5}]},{"hash":"328758055627623128","title":"Oxidative stress response and DNA repair","description":"This cluster shows strong representation of cellular response to oxidative stress and DNA repair terms, suggesting proteins involved in maintaining genome integrity under oxidative conditions. Supporting terms in nucleotide metabolism (AMP salvage, NAD+ biosynthesis, ATP metabolism) and some vesicle/endosomal processes hint at coordinated energy/nucleotide supply and trafficking during stress, but the core theme centers on protecting DNA integrity under oxidative stress.","confidence":"Medium","size":5,"edges":9,"triangles":7,"max_degree":4,"top_function":"DNA repair","top_go_terms":[{"id":"GO:0034599","count":3},{"id":"GO:0044209","count":3},{"id":"GO:0006281","count":3},{"id":"GO:0070676","count":2},{"id":"GO:0030420","count":2}]},{"hash":"656465649654238561","title":"Interferon-driven antiviral response","description":"This cluster\u2019s top GO terms are dominated by positive regulation of type I interferon production and innate antiviral defense (e.g., interferon-beta production, defense response to virus). While a few terms relate to RNA polymerase III transcription and DNA repair, the strongest signals center on interferon-mediated antiviral signaling, which best explains the cluster\u2019s functional theme.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0032481","count":2},{"id":"GO:0045087","count":1},{"id":"GO:0032728","count":1},{"id":"GO:0051607","count":1},{"id":"GO:0042797","count":1}]},{"hash":"811272363389535001","title":"Regulatory control of transcription, chromatin, and cell fate","description":"The GO terms point to broad regulatory roles across transcription (RNA Pol II), chromatin remodeling and histone modification, ubiquitination, splicing, and signaling pathways that govern cell fate decisions such as cell cycle, apoptosis, and necroptosis. This suggests a cohesive theme of modulating gene expression and cellular outcomes rather than a single metabolic function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071157","count":1},{"id":"GO:0043066","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0060544","count":1},{"id":"GO:0034121","count":1}]},{"hash":"792661896377919244","title":"Meiosis and Mitotic Chromosome Segregation","description":"Dominant GO terms describe mitotic/meiosis-specific chromosome segregation, cohesion, and metaphase chromosome alignment, indicating the proteins likely participate in chromosome segregation during cell division. A few terms touch ubiquitin-mediated processes and NF-\u03baB-related signaling, which may reflect ancillary regulatory connections or shared components but do not define the core function of this cluster.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000070","count":1},{"id":"GO:0007112","count":1},{"id":"GO:0007060","count":1},{"id":"GO:0007065","count":1},{"id":"GO:0007080","count":1}]},{"hash":"338792125678087782","title":"Unknown","description":"Top terms are diverse: DNA demethylation, DNA recombination, mRNA stability regulation, redox homeostasis, corneocyte development, aging, hormone-response, and other unrelated processes. There is no clear, unified function linking these terms, and several are obsolete, so a coherent cluster label cannot be inferred.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000466","count":2},{"id":"GO:0080111","count":2},{"id":"GO:0007568","count":2},{"id":"GO:0003335","count":2},{"id":"GO:0045454","count":2}]},{"hash":"340848938038283075","title":"NF-kappaB Activation via Ubiquitination","description":"The cluster is dominated by ubiquitination-related terms (K63-linked ubiquitination, autoubiquitination, regulation of ubiquitin-dependent processes) and NF-kappaB signaling (positive regulation of canonical NF-kappaB signaling and TNF-mediated signaling). Aggresome assembly and hints at RIG-I pathways further support a link to immune signaling workflows that rely on ubiquitin tagging to control NF-kappaB activation. This makes the label a specific, representative summary of the cluster\u2019s function.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"autophagy","top_go_terms":[{"id":"GO:1903265","count":4},{"id":"GO:0070534","count":4},{"id":"GO:0051865","count":4},{"id":"GO:0070842","count":4},{"id":"GO:0043123","count":4}]},{"hash":"632860330590750858","title":"VEGF/HGF Signaling with Angiogenesis and Axon Guidance","description":"This cluster centers on VEGF receptor signaling and HGF receptor signaling, with strong representation of angiogenesis and vascular morphogenesis terms, plus several axon guidance and paranode-associated terms, suggesting a combined role in growth factor\u2013driven vascular development and neural pathfinding.","confidence":"High","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":"carbohydrate metabolic process","top_go_terms":[{"id":"GO:0048010","count":4},{"id":"GO:0002175","count":4},{"id":"GO:0048012","count":3},{"id":"GO:0001868","count":3},{"id":"GO:1902378","count":3}]},{"hash":"2164608600280456125","title":"Developmental signaling and stress responses","description":"The GO terms cover developmental processes (skeletal system development, regulation of myoblast differentiation, prostate gland development) alongside broad signaling and stress-related activities (peptidyl-serine phosphorylation regulation, PI3K/AKT signaling, nitric oxide biosynthesis, hypoxia response, mechanical stimulus response, and immune defense). This mix suggests a broad theme of signaling pathways coordinating development with responses to cellular stress, rather than a single specific function.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033138","count":2},{"id":"GO:0001501","count":2},{"id":"GO:0045662","count":2},{"id":"GO:0045429","count":2},{"id":"GO:0051897","count":2}]},{"hash":"1391773970648967494","title":"Innate Immunity and Oxidative Burst","description":"The GO terms point to innate defense mechanisms, including innate immune response, opsonization, and positive regulation of reactive oxygen species and nitric oxide production, indicating a coordinated antimicrobial response. The presence of a \u201cresponse to yeast\u201d term supports pathogen-related signaling, while a few terms appear peripheral or obsolete; overall, the set centers on host defense via innate immunity and oxidative mechanisms.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0044869","count":1},{"id":"GO:0008228","count":1},{"id":"GO:0010888","count":1},{"id":"GO:0032930","count":1},{"id":"GO:0001878","count":1}]},{"hash":"2049962906242164589","title":"Renin-angiotensin system and ciliary assembly","description":"The top terms center on the renin-angiotensin system (regulation of renal output by angiotensin, renin secretion, brain RAS), with additional terms linking to motile cilium/flagellum biology and spermatogenesis. This suggests a cohesive cluster of RAS components partnering with ciliary/flagellar processes, particularly relevant to sperm development and movement as well as tissue-specific RAS signaling.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002019","count":1},{"id":"GO:0007283","count":1},{"id":"GO:0044458","count":1},{"id":"GO:0002035","count":1},{"id":"GO:0002001","count":1}]},{"hash":"2274812844837260818","title":"Neural Development and Glutamate Biosynthesis","description":"The cluster is enriched for neural development terms (in utero embryonic development, neuron maturation, neural precursor proliferation) and for metabolic steps tied to glutamate production and energy metabolism (L-glutamate biosynthetic process, 2-oxoglutarate metabolism, dihydrolipoamide metabolism), with membrane potential regulation and xenobiotic response signals supporting neuronal function and metabolic control.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulation of DNA-templated transcription","top_go_terms":[{"id":"GO:0001701","count":4},{"id":"GO:0042551","count":4},{"id":"GO:0051068","count":3},{"id":"GO:0097054","count":3},{"id":"GO:0051572","count":3}]},{"hash":"501715660410809626","title":"Muscle development and angiogenesis signaling","description":"The prominent terms include myoblast differentiation, angiogenesis, and multicellular organism development, suggesting a developmental signaling cluster centered on muscle lineage and vascular formation. ERK signaling and GTPase activity regulation provide the mechanism linking these processes, while a few terms like RNA export or cell cycle steps are less central.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":2},{"id":"GO:0070371","count":2},{"id":"GO:0048505","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0045445","count":2}]},{"hash":"1536426009713199336","title":"Developmental signaling and vascular morphogenesis","description":"The cluster centers on developmental signaling pathways, including axon guidance, VEGF signaling, and endothelial/angiogenesis-related morphogenesis (with BMP responses), suggesting a theme of developmental patterning and blood vessel formation; other terms appear less coherently tied to this core theme.","confidence":"Medium","size":5,"edges":10,"triangles":10,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0033564","count":1},{"id":"GO:0043569","count":1},{"id":"GO:1900748","count":1},{"id":"GO:0019836","count":1},{"id":"GO:0006957","count":1}]},{"hash":"727764416768718925","title":"Unknown","description":"Top terms are a mix of diverse, seemingly unrelated processes (plant vernalization, heart development, fibroblast apoptosis regulation, histone ubiquitination, female genitalia development, radiation and vitamin D responses, endothelial adhesion, prostaglandin biosynthesis, and redox). The cluster has no edges and includes obsolete terms, offering no coherent shared function to define a meaningful label. Therefore, Unknown with None confidence.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010048","count":2},{"id":"GO:0003222","count":2},{"id":"GO:2000270","count":2},{"id":"GO:0016574","count":2},{"id":"GO:0030540","count":2}]},{"hash":"1000618922946727114","title":"Organogenesis and Developmental Patterning","description":"The top GO terms point to embryonic development, differentiation, and organ formation (podocyte differentiation, circulatory system and ureter development, mesenchyme migration, left-right patterning, spinal cord neuron fate). A single coherent theme across these terms is developmental patterning and organogenesis, with some neural development signals also represented. This label is representative of the cluster\u2019s overall function.","confidence":"High","size":5,"edges":7,"triangles":3,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0042297","count":5},{"id":"GO:0072112","count":5},{"id":"GO:0072358","count":5},{"id":"GO:0090131","count":5},{"id":"GO:0035947","count":5}]},{"hash":"396637025851394098","title":"Stress- and immune-signaling pathways","description":"The cluster shows frequent GO terms related to responding to various stimuli (glucose, dsRNA, prostaglandin), activation of MAPK signaling, and processes tied to cell movement and immune regulation, suggesting a common theme of signal transduction in stress and immune contexts. Some terms (vagina development, cholesterol biosynthesis) are outliers, so the label is a best-fit generalization rather than a precise single pathway.","confidence":"Medium","size":5,"edges":6,"triangles":2,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:0071333","count":4},{"id":"GO:0043330","count":4},{"id":"GO:0001954","count":2},{"id":"GO:0002688","count":2},{"id":"GO:0000196","count":2}]},{"hash":"1188230149554188983","title":"Unknown","description":"The GO terms are highly heterogeneous, spanning glycosylation, signaling, immune response, development, and synaptic processes, with no clear common function across the cluster, and there are no interactions among proteins to anchor a specific label.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060049","count":1},{"id":"GO:0046329","count":1},{"id":"GO:0035269","count":1},{"id":"GO:0071639","count":1},{"id":"GO:0071699","count":1}]},{"hash":"1682391323777021819","title":"Unknown","description":"The terms span circadian rhythm, several catabolic and one-carbon metabolic processes, pyridoxine (vitamin B6) biosynthesis, and an inflammatory response, with several obsolete terms; there is no clear, cohesive function uniting all terms, so a specific label is unreliable.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0042745","count":2},{"id":"GO:0046392","count":2},{"id":"GO:0042183","count":2},{"id":"GO:0002439","count":2}]},{"hash":"1322809389470590821","title":"Unknown","description":"The GO terms are highly heterogeneous (chromatin assembly, GPCR opsin signaling, inflammatory wound response, cAMP biosynthesis, oocyte maturation regulation, vascular smooth muscle relaxation, phosphorelay signaling, phototaxis, hypoxia detection, and guanylyl cyclase signaling), with no clear shared function or pathway dominating the cluster.","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0006335","count":1},{"id":"GO:0016056","count":1},{"id":"GO:0090594","count":1},{"id":"GO:0006171","count":1},{"id":"GO:1900194","count":1}]},{"hash":"1725740668735198731","title":"Carbohydrate metabolism and osmotic stress response","description":"Most terms point to carbohydrate metabolism (glycogen and sucrose pathways, glycolipid biosynthesis) and osmotic or abiotic stress responses (flooding, sorbitol). There is also bacillithiol biosynthesis, suggesting redox-related metabolism; a couple of obsolete GO entries reduce interpretability. Overall, the cluster seems to reflect sugar metabolism with osmotic/abiotic stress responsiveness.","confidence":"Medium","size":5,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0009413","count":1},{"id":"GO:0005978","count":1},{"id":"GO:0009247","count":1},{"id":"GO:0072708","count":1}]},{"hash":"1897087928425640946","title":"Neural Synaptic Transmission and Brain Development","description":"The cluster centers on neural functions: regulation of synaptic vesicle endocytosis and neurotransmitter secretion, memory, and circadian rhythms, plus retina development and brain-related muscle development contexts, with ubiquitin-dependent protein turnover and stress responses aligning with neural tissue regulation.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900242","count":3},{"id":"GO:0042787","count":2},{"id":"GO:0048741","count":2},{"id":"GO:0042748","count":2},{"id":"GO:0007613","count":2}]},{"hash":"1221709178554892587","title":"RNA methylation and translation machinery","description":"This cluster is enriched for RNA modification and translation-related GO terms: tRNA methylation, rRNA modification, N-terminal methylation, and cytoplasmic translation, suggesting a shared role in RNA processing and protein synthesis. Some other terms are peripheral (lipid biosynthesis, nodulation), but the central theme remains RNA modification and translation.","confidence":"Medium","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006656","count":2},{"id":"GO:0035155","count":2},{"id":"GO:0030488","count":1},{"id":"GO:0009060","count":1},{"id":"GO:0002181","count":1}]},{"hash":"210284045385052161","title":"Embryonic neural and sensory organ development","description":"The cluster\u2019s terms are dominated by brain and sensory system development (cerebellum, forebrain, visual perception, retinal and axon guidance, inner ear, cranial skeleton morphogenesis), pointing to an embryonic program guiding neural and sensory organ formation. There are also broad embryonic organogenesis terms (placenta, thyroid, muscle), suggesting a general developmental theme, but the strongest signal centers on neural and sensory morphogenesis.","confidence":"High","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0021549","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0001890","count":3},{"id":"GO:0048839","count":3},{"id":"GO:0008045","count":3}]},{"hash":"1416613141998350570","title":"Nephron Tubule Morphogenesis","description":"This cluster is dominated by GO terms tied to kidney development and nephron tubule formation (metanephric duct/tubule development, proximal/distal tubule morphogenesis, ascending limb development), indicating a cohesive theme of renal organogenesis. Some terms like cartilage condensation and lymph vessel morphogenesis are less central but do not override the kidney-focused signal. Overall, the cluster represents nephron and kidney tubule development.","confidence":"High","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0072177","count":3},{"id":"GO:0072218","count":3},{"id":"GO:0036303","count":3},{"id":"GO:0001502","count":3},{"id":"GO:0072287","count":3}]},{"hash":"167276882134025721","title":"Endocytosis and intracellular protein processing","description":"The top GO terms converge on internalization and intracellular handling of proteins\u2014receptor-mediated endocytosis, transferrin transport, and various proteolytic/processing steps in the secretory/lysosomal pathway (vacuolar protein catabolism, ERAD-related glycoprotein trimming, membrane protein proteolysis, and related deglutamylation). A single term about isotype switching seems unrelated, but overall the cluster appears to consist of proteins involved in endocytosis and subsequent protein processing/degradation.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007039","count":1},{"id":"GO:0006898","count":1},{"id":"GO:0045830","count":1},{"id":"GO:0098707","count":1},{"id":"GO:0006879","count":1}]},{"hash":"1995772847543569164","title":"Unknown","description":"There are 5 proteins with no edges, no triangles, and no GO terms available, so there is no discernible shared function or pathway to name the cluster. The lack of connections and annotations prevents a meaningful label beyond Unknown.","confidence":"","size":5,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2117973149214996158","title":"Unknown","description":"Unknown","confidence":"","size":5,"edges":3,"triangles":0,"max_degree":2,"top_function":"cytoskeleton organization","top_go_terms":[{"id":"GO:0030516","count":4},{"id":"GO:0019557","count":4},{"id":"GO:0048666","count":4},{"id":"GO:0007411","count":4},{"id":"GO:0006147","count":4}]},{"hash":"192601962518578179","title":"Cell signaling and gene regulation","description":"These five proteins are linked to multiple GO terms covering signaling pathways (Wnt, NOD2) and gene expression control (transcription regulation, mRNA processing), along with roles in cell growth, development (endothelial differentiation, epithelial polarity), and immune modulation (IL-12 regulation). The shared theme is regulation of signaling and gene expression programs that influence cell behavior and tissue development, rather than a single pathway. Therefore this label best fits the cluster.","confidence":"Medium","size":5,"edges":4,"triangles":0,"max_degree":4,"top_function":null,"top_go_terms":[{"id":"GO:1900383","count":4},{"id":"GO:0070431","count":4},{"id":"GO:0000083","count":4},{"id":"GO:0006397","count":4},{"id":"GO:0045083","count":4}]},{"hash":"994236313880126946","title":"Ubiquitin-Dependent Degradation and Signaling","description":"The GO terms point to ubiquitin-mediated proteolysis (ERAD, polyubiquitination, ubiquitin-dependent protein catabolic process) and regulatory signaling pathways (negative regulation of RIG-I signaling, transcription by RNA polymerase II, NF-\u03baB activation, Wnt receptor downregulation). The plus-end-directed microtubule transport suggests trafficking of ubiquitinated proteins to degradation sites. Taken together, the cluster seems to group proteins involved in ubiquitin-driven protein turnover that modulates signaling and transcription rather than a single metabolic function.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0039536","count":2},{"id":"GO:0000122","count":2},{"id":"GO:0097039","count":1},{"id":"GO:0050999","count":1}]},{"hash":"326605085579303701","title":"RNA Pol II Transcription Regulation","description":"This cluster is mainly characterized by regulation of transcription by RNA polymerase II (positive and negative regulation), suggesting a core function in transcription control. Additional terms point to neural development and early embryonic development, with a few mitochondrial and protein quality-control processes appearing less frequently. The transcription regulation signal is the strongest across terms, making this a reasonable cluster label, though the diversity reduces cohesion.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0006357","count":2},{"id":"GO:0045648","count":2},{"id":"GO:0048935","count":2},{"id":"GO:0090009","count":2},{"id":"GO:0000122","count":2}]},{"hash":"1987861469652762468","title":"Ubiquitin-Dependent Proteolysis and NF-kB/JNK Signaling","description":"The top terms cluster around ubiquitin-mediated protein degradation (ubiquitin-dependent proteolysis, K63-linked ubiquitination) and activation/regulation of NF-kappaB and JNK signaling, suggesting proteins here function together in ubiquitin-driven proteolysis linked to these signaling pathways.","confidence":"High","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0097039","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0070534","count":2},{"id":"GO:1903265","count":2}]},{"hash":"2053104959051147690","title":"Sumoylation and ISG15 conjugation in innate immunity","description":"These proteins show enrichment for ubiquitin-like modification processes (SUMO, ISG15 conjugation, and urmylation) together with a term tied to innate immune signaling (positive regulation of MyD88-dependent TLR signaling). This suggests a theme of post-translational modification regulating immune pathways. Some peripheral terms (cadmium response, autophagy-related processes) may reflect broader stress responses or noise in a small cluster.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0034126","count":2},{"id":"GO:0016925","count":2},{"id":"GO:0071276","count":2},{"id":"GO:1903071","count":2},{"id":"GO:0061504","count":1}]},{"hash":"1997608256399695877","title":"Ubiquitin-mediated cell cycle control","description":"Top terms center on different ubiquitin linkages (K63, K11, K27) and ubiquitination processes, with supporting hints from JNK signaling and spindle/chiasma-related cell cycle events. Although some terms are marked obsolete, the recurring theme is ubiquitin-dependent regulation of protein turnover and chromosome segregation, i.e., cell cycle control via ubiquitination.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"chromosome segregation","top_go_terms":[{"id":"GO:1902426","count":4},{"id":"GO:0051569","count":4},{"id":"GO:1903955","count":4},{"id":"GO:0070534","count":4},{"id":"GO:0031505","count":4}]},{"hash":"1350333014983698992","title":"Actin Cytoskeleton Remodeling and Vesicle Trafficking","description":"The top terms center on actin filament polymerization, formin-nucleated actin cables, and stress fiber assembly, all pointing to dynamic actin remodeling regulated by GTPases. Additional terms involve vesicle trafficking and exocytosis (synaptic vesicle exocytosis, Golgi vesicle budding, dopamine uptake at synapses), suggesting the proteins influence vesicle transport via cytoskeletal dynamics. Together, this points to actin-driven remodeling supporting vesicle trafficking and synaptic processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000186","count":3},{"id":"GO:2000300","count":3},{"id":"GO:0090338","count":3},{"id":"GO:0051496","count":3},{"id":"GO:0030838","count":3}]},{"hash":"570213792410669811","title":"Ubiquitin-dependent proteolysis and NF-kappaB signaling","description":"GO terms point to ubiquitin-dependent protein catabolism and ubiquitination (e.g., ubiquitin-dependent proteolysis and ubiquitin tagging) alongside regulation of the NF-kappaB pathway (NIK activation and I-kappaB phosphorylation). There is also a link to transcriptional regulation, suggesting broader control of gene expression. Some terms (peroxisome matrix import, Wnt catabolic process, eye morphogenesis) seem less directly related and may reflect broader or overlapping annotations, but the core theme centers on proteostasis-related ubiquitination and NF-kappaB signaling.","confidence":"Medium","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0016558","count":3},{"id":"GO:0070535","count":3},{"id":"GO:1903721","count":3},{"id":"GO:0000122","count":3}]},{"hash":"448135217071698795","title":"Cell-surface receptor signaling and adhesion","description":"The GO terms are centered on processes at the plasma membrane, including cell-surface localization, cell-matrix adhesion, activation of transmembrane receptor TYK activity, and pattern-recognition receptor signaling, pointing to membrane-associated signaling and adhesion. Some terms touch extracellular processes like triglyceride homeostasis and angiogenesis, but the overarching theme remains cell-surface signaling and adhesion. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051005","count":1},{"id":"GO:0002752","count":1},{"id":"GO:0007160","count":1},{"id":"GO:0034394","count":1},{"id":"GO:0007171","count":1}]},{"hash":"1928780480030751819","title":"Male germline meiosis and spermatogenesis","description":"The top GO terms are dominated by male germline and meiotic processes (germ-line cyst formation, spermatocyte division, G2/M transition of the meiotic cell cycle), suggesting a focus on male germline development and meiosis. Other terms relate to general RNA processing and translation, which are broader contexts but less central to this cluster's core signal.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":1},{"id":"GO:0048136","count":1},{"id":"GO:1905537","count":1},{"id":"GO:1905606","count":1},{"id":"GO:0048137","count":1}]},{"hash":"217165786936719512","title":"Unknown","description":"The top GO terms span several distinct biological areas\u2014immune signaling (IL-2 production, T cell polarity), lipid metabolism (SREBP signaling, cholesterol biosynthesis regulation), protein quality control (ubiquitin-dependent ERAD), mitochondrial dynamics, and podocyte development. There isn\u2019t a clear, single function or pathway that unites these terms for this small protein set, so a cohesive label cannot be confidently assigned.","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":2},{"id":"GO:0060355","count":2},{"id":"GO:0045541","count":2},{"id":"GO:0001302","count":2},{"id":"GO:0032623","count":2}]},{"hash":"1659690387506616474","title":"Multi-tissue signaling and apoptosis","description":"The proteins appear linked to broad signaling and regulatory processes across tissues, including TGF-beta and growth hormone responses, GTPase activity regulation, SREBP signaling, mitochondria-nucleus communication, developmental contexts (lens, seminiferous tubules), and apoptotic processes in cardiac and glial cells. This points to a general theme of signaling and tissue-level regulation rather than a single cohesive function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010659","count":2},{"id":"GO:0070306","count":2},{"id":"GO:0071560","count":2},{"id":"GO:0043547","count":2},{"id":"GO:0034349","count":2}]},{"hash":"2206205364730161047","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0000398","count":3},{"id":"GO:0048026","count":3},{"id":"GO:0031124","count":2},{"id":"GO:1990417","count":2},{"id":"GO:0042273","count":2}]},{"hash":"581003815339649227","title":"Organelle proteostasis and metabolism","description":"This cluster centers on proteins involved in organelle maintenance and function, notably peroxisome matrix import, protein lipoylation, and glycine cleavage, which ties to mitochondrial metabolism via lipoylated enzyme complexes. It also includes proteostasis and quality control (misfolded protein handling, ERAD), oxidative stress response, and trafficking-related processes (intralumenal vesicle formation, microtubule dynamics, cell cycle). The varied terms collectively point to a theme of maintaining organelle proteostasis and coordinating stress responses, rather than a single narrowly defined pathway.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016558","count":2},{"id":"GO:0034599","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0019464","count":1},{"id":"GO:0009249","count":1}]},{"hash":"2155753349035664316","title":"Developmental Neuroimmune Signaling","description":"The proteins point to signaling and development across systems: TGF-beta and IL-27/STAT pathways, cell-matrix adhesion, and neural/synaptic organization (dendritic spines), alongside embryonic development terms like axial mesoderm and genital development, suggesting a theme of developmental signaling with neural-immune integration.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:2001202","count":4},{"id":"GO:0050925","count":4},{"id":"GO:0001954","count":4},{"id":"GO:0060068","count":4},{"id":"GO:0050808","count":4}]},{"hash":"1126634524996296853","title":"Ribosome Biogenesis and Translation","description":"Based on the GO terms, the strongest signals are assembly of large subunit preribosome, positive regulation of ribosome biogenesis, and translation, indicating a shared role in ribosome formation and protein synthesis. Some other terms (apoptosis in heart/glia, lens differentiation, growth hormone signaling) are less connected to ribosome biology, but the core cluster theme aligns with ribosomal assembly and function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1902626","count":1},{"id":"GO:0090070","count":1},{"id":"GO:0006412","count":1},{"id":"GO:1902426","count":1},{"id":"GO:0010659","count":1}]},{"hash":"662354699488334186","title":"Unknown","description":"The GO terms are very diverse, including various biosynthetic processes (L-glutamine metabolism, UDP-xylose, O antigen, colanic acid, wax, poly-hydroxybutyrate, sporopollenin) as well as hair follicle development and transcription, with no clear shared function or pathway across the cluster. Edges are zero, providing no cohesive functional signal to tie the proteins together, so a specific, representative label cannot be assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006541","count":1},{"id":"GO:0033320","count":1},{"id":"GO:0009243","count":1},{"id":"GO:0001942","count":1},{"id":"GO:0010025","count":1}]},{"hash":"1124111830833085950","title":"Epithelial morphogenesis and cell adhesion","description":"The terms cluster around developmental processes shaping tissues (fungiform papilla and hair follicle placode formation, mesenchymal proliferation in organ development) and processes related to cell\u2013cell contacts (adherens junction assembly, cell communication). Positive regulation of GTPase activity supports cytoskeletal remodeling essential for morphogenesis and junction formation, suggesting the proteins act together in tissue development and adhesion. Some other terms (centromere cohesion, ER calcium, proteasome localization) are broader but don\u2019t override the central theme of morphogenesis and adhesion.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0061198","count":4},{"id":"GO:0070602","count":4},{"id":"GO:0043547","count":4},{"id":"GO:0060789","count":4},{"id":"GO:0060916","count":4}]},{"hash":"2060418858809254623","title":"Developmental signaling and cell cycle regulation","description":"This cluster co-occurs with multiple signaling-related GO terms (GABA and glutamate receptor signaling, EGF stimulus response, IGF receptor signaling) and processes tied to calcium signaling (store-operated calcium channel activation). It also includes terms tied to egg activation, meiosis initiation, cell cycle transitions (G2/M), and differentiation, suggesting a theme around signaling pathways that regulate development, cell cycle progression, and differentiation. The combination of signaling pathways and developmental cell cycle events supports labeling this cluster as a developmental signaling and cell cycle regulation group, though the exact functional connections are broad and context-dependent.","confidence":"Medium","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0007343","count":2},{"id":"GO:0046673","count":2},{"id":"GO:0007214","count":2},{"id":"GO:0060466","count":2},{"id":"GO:0071364","count":2}]},{"hash":"1123895919017168260","title":"Unknown","description":"The GO terms span developmental signaling (salivary gland branching, HGF signaling, myoblast differentiation and proliferation), extracellular matrix regulation, coagulation, immune signaling (T cell activation), and kinase pathways (p38MAPK). With no single shared function or cohesive pathway across the four proteins, there isn't a clear, specific label to assign beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0060665","count":1},{"id":"GO:0048012","count":1},{"id":"GO:0045445","count":1},{"id":"GO:1902947","count":1},{"id":"GO:0030212","count":1}]},{"hash":"876294749081276546","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":"regulatory ncRNA-mediated gene silencing","top_go_terms":[{"id":"GO:0031047","count":3},{"id":"GO:0045657","count":2},{"id":"GO:0000335","count":2},{"id":"GO:0048025","count":2},{"id":"GO:0045451","count":2}]},{"hash":"1679803619182542515","title":"Cytoskeleton remodeling and vesicle trafficking","description":"The GO terms cluster around cytoskeletal dynamics (positive regulation of GTPase activity, actin filament reorganization, cell migration) and vesicle-related processes (synaptic vesicle budding, acrosome assembly, lysosomal membrane organization, phosphoinositide signaling), suggesting these proteins participate in membrane remodeling and vesicle trafficking driven by GTPase signaling. While some terms are context-specific, the shared emphasis on cytoskeleton and vesicle dynamics supports this label.","confidence":"Medium","size":4,"edges":4,"triangles":1,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0043547","count":1},{"id":"GO:0030037","count":1},{"id":"GO:0033028","count":1},{"id":"GO:0001675","count":1},{"id":"GO:0097212","count":1}]},{"hash":"2066849319619933342","title":"Mitotic Regulation and Chromatin Modification","description":"The cluster\u2019s top GO terms center on mitosis and proteolysis (cell division, mitotic cell cycle, APC-dependent catabolic process) and on chromatin modification (histone methylation and ubiquitin signaling via K11-linked ubiquitination). This suggests a cohesive theme around mitotic control and chromatin dynamics, with a few additional terms (cadmium response, muscle apoptosis) that are less central. Therefore, the label reflects the core functions of the group.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001162","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000278","count":2}]},{"hash":"1056816268081358008","title":"Unknown","description":"The terms show disparate processes: RNA splicing, ADP-ribosylation regulation, wing disc morphogenesis, and ribosome biogenesis, with no shared pathway or interaction pattern. Given the lack of a unifying theme and no network structure, we cannot assign a meaningful label beyond Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0000387","count":1},{"id":"GO:0010835","count":1},{"id":"GO:0007475","count":1},{"id":"GO:0042273","count":1}]},{"hash":"1864731105586481838","title":"Unknown","description":"There's no shared GO signal in Top Terms; with 4 proteins, 0 edges, and no triangles, there are no enriched terms to tie the proteins together. Without consistent functional annotations or interactions, a meaningful label cannot be assigned, so the cluster remains Unknown.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"1801386834373691473","title":"Unknown","description":"There are no shared GO terms or interactions visible; the cluster has 0 edges and no top terms, so there is no clear functional theme to bind the proteins.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"439163692053899994","title":"Unknown","description":"The terms come from unrelated processes (oxidation\u2013reduction, iron response, immunoglobulin production, dorsal/ventral axis development, integrin activation, cholesterol transport, etc.) and there are no interactions among the four proteins. This does not reveal a coherent shared function for the cluster, so Unknown is the appropriate label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":1},{"id":"GO:0010039","count":1},{"id":"GO:0002642","count":1},{"id":"GO:0009951","count":1},{"id":"GO:0033622","count":1}]},{"hash":"929596673140261695","title":"Neuronal synaptic plasticity and calcium signaling regulators","description":"The top GO terms are dominated by neuronal signaling and plasticity, including negative regulation of postsynaptic calcium concentration, regulation of long-term potentiation, and regulation of neuronal synaptic plasticity, pointing to proteins that modulate synaptic strength and calcium dynamics in neurons. Other terms (glucocorticoid response, heart contraction, muscle differentiation, methylation) are present but less central to the core theme; thus the label emphasizes the neural plasticity angle with calcium signaling. ","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:1903799","count":2},{"id":"GO:1900271","count":2},{"id":"GO:2001015","count":2},{"id":"GO:0099566","count":2},{"id":"GO:0051384","count":2}]},{"hash":"1529564307622259103","title":"Cell signaling and protein modification","description":"This cluster centers on core cellular signaling and how proteins are regulated post-translationally. The terms include ERK cascade regulation, GTPase activity, and monoubiquitination, with an immune context (T cell anergy) and mentions of translation and stress responses, suggesting a theme of signaling-driven control of protein function and gene expression.","confidence":"Medium","size":4,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0031064","count":2},{"id":"GO:0002669","count":2},{"id":"GO:0046898","count":1},{"id":"GO:0046677","count":1},{"id":"GO:0006412","count":1}]},{"hash":"2246884069906622591","title":"DNA Transposition and Proviral Integration","description":"Top GO terms include DNA transposition, DNA integration, and establishment of integrated proviral latency, pointing to a theme of mobile genetic elements and viral genome integration. Other terms appear more disparate (cell cycle, development, etc.), likely representing background annotations. Hence, the label reflects the core motif of DNA mobility and proviral latency with moderate confidence.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046718","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0006313","count":1},{"id":"GO:0007049","count":1},{"id":"GO:0015074","count":1}]},{"hash":"85645834129430835","title":"Cellular stress response and lipid metabolism","description":"This cluster features GO terms tied to stress responses (response to unfolded protein; stress-related cardiac hypertrophy) and lipid/isoprenoid metabolism (mevalonate pathway regulation, isoprenoid biosynthesis, sphingomyelin catabolism, lipid A biosynthetic process). Although some terms are divergent or outdated, the prominent signal is a link between cellular stress signaling and lipid/metabolic pathways, suggesting proteins functioning in stress-related metabolic regulation. Confidence: Medium.","confidence":"","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":"DNA replication","top_go_terms":[{"id":"GO:1903799","count":4},{"id":"GO:0006986","count":4},{"id":"GO:0099566","count":4},{"id":"GO:0051037","count":4},{"id":"GO:0009245","count":4}]},{"hash":"354812932071179942","title":"NF-kappaB/TNF Signaling Regulation via Ubiquitin-Dependent Degradation","description":"This cluster is dominated by GO terms tied to inflammatory signaling and its regulation through ubiquitin-mediated proteolysis, including activation of NF-kappaB-inducing kinase, positive regulation of TNF signaling, and regulation of JNK cascade, plus ubiquitin-dependent protein catabolic processes (ERAD). These points suggest a coherent theme of signaling control and receptor turnover governed by ubiquitin pathways. A few terms (like peroxisomal import) are less central but do not override the core pattern of NF-kB/TNF pathway regulation via degradation. Confidence reflects the clear linkage of the majority of terms to this theme.","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":2},{"id":"GO:0038018","count":2},{"id":"GO:0042787","count":2},{"id":"GO:1903265","count":2},{"id":"GO:1901253","count":2}]},{"hash":"1899006691301577990","title":"Unknown","description":"The GO terms are split between energy/metabolic processes (proton transport, proton motive force-driven ATP synthesis, vacuolar acidification) and various development or unrelated processes (caudal fin development, skeletal muscle development, notochord vacuolation, B cell signaling, spindle localization). With no clear, single cohesive function or strong connectivity among the proteins, there isn\u2019t a consistent theme to bind them into a specific, high-level label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051260","count":2},{"id":"GO:0060036","count":1},{"id":"GO:0015991","count":1},{"id":"GO:0042777","count":1},{"id":"GO:0007035","count":1}]},{"hash":"438403478457755496","title":"Innate immune NF-kappaB signaling and ubiquitination","description":"This cluster centers on innate immune signaling and NF-kappaB regulation, highlighted by terms for innate immune response, TNF-mediated signaling, and various ubiquitination processes (including K63-linked and autoubiquitination), suggesting a functional module where ubiquitylation modulates NF-kappaB\u2013driven immune signaling. Some terms are obsolete or peripheral, but the dominant theme is innate immune signaling linked to ubiquitination. ","confidence":"High","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0051092","count":2},{"id":"GO:0051865","count":2},{"id":"GO:0070534","count":2},{"id":"GO:0045087","count":2},{"id":"GO:1903265","count":2}]},{"hash":"515072934666537552","title":"Ubiquitin-Dependent Proteolysis (ERAD)","description":"The proteins in this cluster are annotated mainly with ubiquitin-dependent protein catabolic processes and ERAD, pointing to a proteostasis/quality-control role via ubiquitin tagging and degradation. Circadian regulation and oligomerization terms are present but less central, so the dominant theme remains ubiquitin-mediated proteolysis.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042787","count":3},{"id":"GO:0030433","count":2},{"id":"GO:0042752","count":2},{"id":"GO:0051260","count":2},{"id":"GO:0097039","count":1}]},{"hash":"1284585245147593158","title":"COPI-mediated ER-Golgi transport","description":"Proteins in this cluster are dominated by GO terms for COPI coating and budding of vesicles, ER lumen protein retention, and ER-to-Golgi transport, which together point to a cohesive function in the secretory pathway and COPI-mediated transport between ER and Golgi. A few developmental terms are present but with single counts, suggesting incidental associations rather than core roles of the cluster.","confidence":"High","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0048205","count":1},{"id":"GO:0035964","count":1},{"id":"GO:0006621","count":1},{"id":"GO:0006888","count":1},{"id":"GO:0070863","count":1}]},{"hash":"498416302805426988","title":"Unknown","description":"The GO terms are diverse and do not point to a single coherent function (ranging from smooth muscle/vascular differentiation and TGF-beta signaling to amyloid-beta clearance, proviral latency, and ncRNA silencing). With no edges linking the proteins, there isn't a clear shared pathway to name, so the cluster appearsUnknown in function.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1900222","count":1},{"id":"GO:2001015","count":1},{"id":"GO:2000721","count":1},{"id":"GO:0060157","count":1},{"id":"GO:0030511","count":1}]},{"hash":"2058086067176316475","title":"Actin Cortical Patch Assembly and Rac Signaling","description":"The top GO terms point to actin cytoskeleton organization at the cortex (actin cortical patch localization/assembly, barbed-end capping, lamellipodium dynamics) and Rac-mediated signaling, with an additional response to growth factors. This suggests a cohesive theme around actin cortex remodeling and signaling, with spermatogenesis appearing in a couple of terms but not driving the cluster\u2019s main function.","confidence":"Medium","size":4,"edges":3,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0007283","count":2},{"id":"GO:0044379","count":1},{"id":"GO:2000814","count":1},{"id":"GO:0000147","count":1},{"id":"GO:0014070","count":1}]},{"hash":"1632567236017072667","title":"Ubiquitin-Driven Degradation and NF-kappaB Signaling","description":"Top GO terms are dominated by ubiquitin-dependent degradation (ERAD, K63-linked ubiquitination) and NF-kappaB signaling components, with innate immune response and Wnt receptor catabolic processes also represented. This pattern suggests a cluster of proteins involved in ubiquitin-regulated proteolysis that modulates immune signaling pathways, including NF-kappaB activation, rather than unrelated functions. Confidence: Medium","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0097039","count":2},{"id":"GO:0050999","count":2},{"id":"GO:0007250","count":2},{"id":"GO:0038018","count":2}]},{"hash":"242009640344323753","title":"RNA Pol II Transcription Regulation","description":"The top GO terms are dominated by transcription-related processes (DNA-templated transcription; positive and negative regulation of transcription by RNA Pol II), suggesting a core function in transcriptional control. Peripheral terms such as protein localization, ubiquitin-dependent catabolic process, vesicle ER fusion, and outer dynein arm assembly may reflect broader cellular context or ancillary roles but do not override the central theme of transcription regulation.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048279","count":1},{"id":"GO:0006511","count":1},{"id":"GO:0000122","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0045944","count":1}]},{"hash":"2013386825104376300","title":"ECM remodeling and immune signaling","description":"The top terms point to extracellular matrix organization/remodeling (hyaluronan metabolism, ECM assembly regulation, chondrocyte morphogenesis) and cell adhesion/signaling (integrin signaling, metallopeptidase activity, extravasation), with immune involvement (T cell activation) and vascular processes (blood coagulation), suggesting a cluster of proteins mediating cell-ECM interactions and immune cell trafficking. An outlier term related to vision appears incidental.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070208","count":3},{"id":"GO:0050908","count":2},{"id":"GO:0003429","count":2},{"id":"GO:0045123","count":2},{"id":"GO:0030212","count":2}]},{"hash":"691544798105578286","title":"Neuronal signaling and ion transport","description":"This cluster is dominated by GO terms related to neural excitability and neurotransmission: potassium and calcium ion transport underpin action potentials; serotonin receptor signaling, action potential, and inhibitory postsynaptic potentials point to synaptic activity; and sensory-related terms (sound detection, mechanical stimulus) align with neuronal signaling and sensory transduction. A few terms about ovulation rhythm and cartilage morphogenesis appear peripheral to the core neural theme, but the central pattern is neural signaling and ion-channel\u2013driven excitability.","confidence":"High","size":4,"edges":6,"triangles":4,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":4},{"id":"GO:0098703","count":3},{"id":"GO:0007210","count":3},{"id":"GO:1901214","count":3},{"id":"GO:0060112","count":3}]},{"hash":"1928892825539661372","title":"Neural Signaling and Sensory Perception","description":"This cluster is driven by neural and sensory processes: visual perception, dopaminergic synaptic transmission, pain perception, and behavioral responses to psychoactive stimuli (e.g., cocaine), along with ERK signaling. A couple of terms (heart development and abscisic acid signaling) appear as outliers, likely annotation noise or cross-species effects, but the core themes are neural signaling and sensory processing.","confidence":"Medium","size":4,"edges":3,"triangles":1,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0007601","count":4},{"id":"GO:0007507","count":4},{"id":"GO:0071380","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0001963","count":3}]},{"hash":"1529880415601452779","title":"Dopaminergic GPCR Signaling and Astrocyte Interaction","description":"The terms point to dopamine receptor\u2013mediated GPCR signaling (adenylate cyclase\u2013activating pathway), including dopamine uptake regulation, calcium and GTPase activity modulation, and glial involvement (astrocyte chemotaxis). Even with a few peripheral terms (renin secretion, peptide response), the dominant theme is dopaminergic neuronal signaling with astrocyte interaction, suggesting a cohesive neural signaling cluster.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":1},{"id":"GO:1900135","count":1},{"id":"GO:2000458","count":1},{"id":"GO:1901652","count":1},{"id":"GO:0018298","count":1}]},{"hash":"282547958094927045","title":"Vascular and Neural Development Signaling","description":"This cluster is characterized by angiogenesis, coronary morphogenesis, axon guidance/extension, and Hedgehog pathway regulation (Smoothened), indicating a shared theme of developmental patterning in vessels and neurons; immune-related terms appear incidental.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002042","count":2},{"id":"GO:0045880","count":2},{"id":"GO:0060982","count":2},{"id":"GO:0001867","count":2},{"id":"GO:0048842","count":2}]},{"hash":"912262497187230670","title":"Glycan biosynthesis and cell wall components","description":"This cluster\u2019s GO terms cluster around glycan production and modification (O-linked glycosylation via threonine/serine and via N-acetyl-galactosamine) and various polysaccharide biosynthetic processes (teichoic acid, cellulose, hyaluronan) plus cell wall organization and UDP-glucose metabolism. Together they point to a cohesive function in building and decorating cell-surface glycans and cell wall components. Immunoglobulin production appears as a minor outlier and may reflect annotation noise rather than a shared function.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0002378","count":2},{"id":"GO:0036108","count":2},{"id":"GO:0019350","count":2},{"id":"GO:0018243","count":2},{"id":"GO:0016266","count":2}]},{"hash":"1832597480119168328","title":"Unknown","description":"Unknown","confidence":"","size":4,"edges":3,"triangles":0,"max_degree":3,"top_function":null,"top_go_terms":[{"id":"GO:0016310","count":1},{"id":"GO:0019379","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0000103","count":1},{"id":"GO:0050428","count":1}]},{"hash":"682142451368292910","title":"Unknown","description":"The GO terms are highly diverse, including nitrosative stress response, retinol metabolism, lignin biosynthesis, various carbon metabolism steps, and respiratory/fermentation processes, with no single dominating function linking all four proteins. There isn\u2019t a clear cohesive biological theme, so a single interpretable label isn\u2019t evident. ","confidence":"","size":4,"edges":5,"triangles":2,"max_degree":3,"top_function":"respiratory system process","top_go_terms":[{"id":"GO:0051409","count":4},{"id":"GO:0042572","count":4},{"id":"GO:0006116","count":4},{"id":"GO:1900116","count":4},{"id":"GO:0009809","count":4}]},{"hash":"2167330749814408432","title":"Neural development and axon guidance","description":"This cluster is driven by neural-development terms: corpus callosum development, positive regulation of synapse assembly, and axonal fasciculation, pointing to roles in brain connectivity and synapse formation. There are also apoptotic and axon-regeneration regulatory terms, reinforcing neural-structure maintenance themes. A few RNA modification terms appear (tRNA methylation, rRNA modification, N-terminal trimethylation) suggesting some multifunctional proteins or annotation noise, but the dominant signal centers on neural development and axon connectivity.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0022038","count":2},{"id":"GO:0051965","count":2},{"id":"GO:0007413","count":2},{"id":"GO:0006915","count":2},{"id":"GO:0048681","count":2}]},{"hash":"1704834608902010088","title":"Unknown","description":"The GO terms include dopamine catabolism, cellular oxidant detoxification, visual perception and behavior, protein adenylylation and its regulation, snoRNP assembly, symbiont-mediated suppression of host translation, histamine transport, and ethanol response, with no single, coherent function linking all four proteins. There isn\u2019t a clear, shared theme to assign a specific, high-confidence label.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042420","count":2},{"id":"GO:0098869","count":2},{"id":"GO:0050908","count":1},{"id":"GO:0018117","count":1},{"id":"GO:0007632","count":1}]},{"hash":"2289233378128053492","title":"Unknown","description":"The GO terms in this cluster span very diverse processes (unfolded protein response, photoreceptor outer segment localization, plant hormone signaling, cardiac and glial apoptotic processes, TGF-beta response, decidualization, and several obsolete terms), with no clear single function tying them together. Because there isn\u2019t a cohesive theme or common biological context across all proteins, a specific, representative label isn\u2019t justifiable. Therefore, the appropriate label is Unknown with no confident representation.","confidence":"","size":4,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006986","count":1},{"id":"GO:1903546","count":1},{"id":"GO:0009938","count":1},{"id":"GO:0010659","count":1},{"id":"GO:0071560","count":1}]},{"hash":"1204774963481667334","title":"Photosynthesis and central carbon metabolism","description":"The top GO terms cluster around energy generation: multiple photosynthesis-related processes (photosynthesis, light reactions, photosystem I electron transport) alongside central carbon metabolism (TCA cycle, fermentation, pyruvate decarboxylation to acetyl-CoA, formate oxidation). A single term like ribosome disassembly is less connected, but the overall theme points to energy production in photosynthetic/central metabolism pathways.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":2},{"id":"GO:0015944","count":1},{"id":"GO:0009773","count":1},{"id":"GO:0008616","count":1},{"id":"GO:0019684","count":1}]},{"hash":"628507552806525861","title":"Metal Ion Transport Across Membranes","description":"This cluster prominently features GO terms for zinc, copper, and cadmium transmembrane transport, suggesting a membrane-associated metal ion transport role. Other terms point to related membrane processes (lipid dephosphorylation, LPS biosynthesis) and xenobiotic metabolism (P450 epoxygenase, stilbene catabolism), which commonly accompany membrane proteins.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016311","count":2},{"id":"GO:0046839","count":2},{"id":"GO:0071577","count":2},{"id":"GO:0070574","count":2},{"id":"GO:0019373","count":2}]},{"hash":"667902821823748028","title":"Unknown","description":"The terms mix adhesion, platelet aggregation, circadian cycle, various catabolic pathways, inflammatory response, and vitamin B6 biosynthesis, with no clear common function. There are no edges among the proteins, suggesting they do not form a cohesive functional module in this cluster. Because no single theme ties the GO terms together, a specific, informative label cannot be confidently assigned.","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0055114","count":3},{"id":"GO:0007160","count":2},{"id":"GO:0070527","count":2},{"id":"GO:0042745","count":1},{"id":"GO:0009087","count":1}]},{"hash":"1086051068372464023","title":"Embryogenesis and Tissue Differentiation Regulators","description":"The top GO terms cluster around developmental processes across various tissues and stages (trophoblast giant cell differentiation, placental development, left-right pattern formation, endocrine system development, cartilage morphogenesis, epithelial-to-mesenchymal transitions in heart development), with ubiquitination indicating regulatory control of protein turnover. While diverse, they point to a shared theme of embryonic tissue differentiation and organogenesis, rather than a single pathway, giving a medium level of confidence in this label.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0033280","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0060707","count":1},{"id":"GO:0035270","count":1},{"id":"GO:0003198","count":1}]},{"hash":"1179435991025774693","title":"Unknown","description":"The GO terms are diverse, spanning protein modification (glycosylation/acetylation), various biosynthetic pathways (ectoine, arginine, carbohydrate, melatonin), and genome regulation, with no clear single function tying the proteins together. ","confidence":"","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006517","count":1},{"id":"GO:0032918","count":1},{"id":"GO:0019491","count":1},{"id":"GO:0006348","count":1},{"id":"GO:0018003","count":1}]},{"hash":"365436408961947496","title":"Dendritic spine maintenance and actin dynamics","description":"This cluster\u2019s terms cluster around neuronal cytoskeleton and synaptic structure, including dendritic spine maintenance and localization to actin cortical patches, plus regulation of endocytosis and GTPase activity which are linked to actin remodeling. While a few immune or behavioral terms appear, the strongest signal is neuronal actin dynamics and spine-related processes.","confidence":"Medium","size":4,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0050894","count":1},{"id":"GO:0051044","count":1},{"id":"GO:0030100","count":1},{"id":"GO:2000821","count":1},{"id":"GO:0044379","count":1}]},{"hash":"2252757245422097249","title":"ER proteostasis and protein processing","description":"Based on the strongest signals, the cluster centers on ER-associated protein handling and quality control, including ubiquitin-dependent ERAD, protein deglycosylation, and regulation of proteasomal degradation, as well as tail-anchored membrane protein insertion into the ER. Some other terms appear tangential (e.g., mitochondrial fusion, ribosomal assembly), but the dominant theme is ER proteostasis.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":3},{"id":"GO:0006517","count":3},{"id":"GO:0010636","count":3},{"id":"GO:1901799","count":3},{"id":"GO:0071816","count":3}]},{"hash":"2083314828881717717","title":"Ion and sugar transmembrane transporters","description":"The top GO terms are dominated by transmembrane transport activities for multiple ions (potassium, sodium, nitrite, nitrate, phosphate) and sugars (galactose), plus a neuronal function of neurotransmitter loading into synaptic vesicles. This points to a coherent theme of membrane transporters that move ions and small molecules across membranes, with one neuronal-specific exception. Overall, a transporter-focused cluster is the best fit. ","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071805","count":2},{"id":"GO:0035435","count":2},{"id":"GO:0015706","count":2},{"id":"GO:0098700","count":2},{"id":"GO:0042128","count":2}]},{"hash":"1780073817183679896","title":"Unknown","description":"The top GO terms are highly diverse and include metabolism, vitamin biosynthesis, transposition/DNA integration, chromatin localization, spindle checkpoint regulation, cardiac and lens differentiation, and TGF-beta signaling, with no clear shared function linking the proteins. The cluster has no edges or coherent functional theme, making it impossible to assign a specific, representative label.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001172","count":1},{"id":"GO:0090180","count":1},{"id":"GO:1903212","count":1},{"id":"GO:0032197","count":1},{"id":"GO:0015074","count":1}]},{"hash":"615972717698893450","title":"X chromosome dosage compensation","description":"GO terms point to dosage compensation of the X chromosome, including assembly of the dosage compensation complex and H4K16 acetylation, a hallmark of transcriptional hyperactivation on the X. This suggests the proteins belong to the dosage compensation machinery rather than unrelated processes. Therefore the label X chromosome dosage compensation accurately reflects the cluster's shared function.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016457","count":1},{"id":"GO:0009047","count":1},{"id":"GO:0043984","count":1}]},{"hash":"1088324384292713011","title":"DNA Replication, Repair, and Damage Response","description":"The proteins clustered here are tied to DNA biosynthesis, replication, and repair, with explicit signals for DNA damage responses (camptothecin and X-ray) and homologous recombination-related steps (DNA strand invasion, reciprocal meiotic recombination), indicating a genome maintenance and replication-focused group.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071897","count":1},{"id":"GO:0006260","count":1},{"id":"GO:0006281","count":1},{"id":"GO:0072757","count":1},{"id":"GO:0001932","count":1}]},{"hash":"1145228115338413324","title":"Neuronal Ion Transport and Membrane Potential","description":"The top GO terms cluster around potassium and calcium ion homeostasis and transport (intracellular potassium homeostasis, potassium import/export, calcium transport), stabilization of membrane potential, and ionotropic glutamate receptor signaling, all of which point to ion channel\u2013mediated neuronal function. The inclusion of cerebellar granule cell differentiation supports a neuron- and brain-specific context. Some terms are ancillary, but the dominant theme is neuronal ion transport and membrane signaling.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030007","count":2},{"id":"GO:0071383","count":2},{"id":"GO:0035235","count":2},{"id":"GO:0030322","count":2},{"id":"GO:0097623","count":2}]},{"hash":"926915637897427518","title":"Developmental signaling and adhesion","description":"The top GO terms cluster around signaling pathways (TGF-beta regulation, IL-27 signaling, STAT phosphorylation) and cell-adhesion processes (cell-matrix adhesion), with supporting terms related to neural morphogenesis (dendritic spine morphogenesis, synapse organization) and embryonic development (vagina development, axial mesoderm formation). This points to a group of proteins coordinating signaling cues with adhesion and morphogenesis during development, rather than a single, specific function.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:2001202","count":3},{"id":"GO:0050925","count":3},{"id":"GO:0001954","count":3},{"id":"GO:0060068","count":3},{"id":"GO:0050808","count":3}]},{"hash":"1733528568696417314","title":"Ribosome biogenesis and translation control","description":"Most top terms center on translation and ribosome biology (cytoplasmic translation, translation, initiation complex formation, ribosome disassembly, ribosomal export from the nucleus, and translational termination/fidelity). A few terms touch cell cycle and cell division, suggesting coordination of protein synthesis with cell proliferation. Overall, the cluster appears to reflect proteins involved in ribosome assembly/transport and the control of translational processes in the cytoplasm.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0046677","count":1},{"id":"GO:0002181","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0000055","count":1},{"id":"GO:0007049","count":1}]},{"hash":"1610043923705110190","title":"Embryo Development and Morphogenesis","description":"GO terms point to embryonic development, axis specification, retina formation, and tissue organization (with some ECM remodeling), suggesting a shared role in developmental morphogenesis across tissues. Some terms like memory are peripheral, but the core signal supports a developmental tissue-formation theme.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0042633","count":2},{"id":"GO:0060579","count":1},{"id":"GO:0033138","count":1},{"id":"GO:0030195","count":1},{"id":"GO:0007613","count":1}]},{"hash":"264572181010481143","title":"Nervous system development and morphogenesis","description":"The top GO terms cluster around broad developmental processes across multiple tissues, with a noticeable emphasis on nervous system formation (forebrain development, axon fasciculation) alongside bone and organ morphogenesis (ossification, pulmonary artery and distal tubule development). This suggests a general developmental function rather than a single, specific pathway, hence a label focused on development with a nervous system emphasis.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007275","count":3},{"id":"GO:0032495","count":2},{"id":"GO:0071372","count":2},{"id":"GO:0043931","count":2},{"id":"GO:0097155","count":2}]},{"hash":"224506687645488961","title":"Unknown","description":"The Top Terms span RNA processing and splicing, cytoskeletal dynamics, muscle assembly, and neural development/behavior with no single cohesive function linking all terms. The mix suggests disparate roles rather than one clear theme for the cluster.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006397","count":1},{"id":"GO:0033120","count":1},{"id":"GO:0030240","count":1},{"id":"GO:0097113","count":1},{"id":"GO:0007019","count":1}]},{"hash":"1843204617155767358","title":"Unknown","description":"The GO terms are spread across vascular and neural development, DNA replication/repair, cell cycle, immune response, and neuronal signaling, with no single cohesive process tying the proteins together. This diversity makes a specific, representative label unlikely.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0043536","count":2},{"id":"GO:0001525","count":2},{"id":"GO:0042220","count":2},{"id":"GO:0014044","count":2},{"id":"GO:0000082","count":2}]},{"hash":"1305750817869579597","title":"ECM remodeling and immune signaling","description":"The GO terms cluster around extracellular matrix dynamics (hyaluronan metabolism, negative regulation of ECM assembly) and immune pathways (complement activation, blood coagulation, T cell activation, integrin signaling), with supporting roles in antigen processing (proteasome assembly) and metallopeptidase activity. This combination points to a group of proteins involved in ECM remodeling that interfaces with immune responses.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030212","count":1},{"id":"GO:1901202","count":1},{"id":"GO:0007596","count":1},{"id":"GO:0002291","count":1},{"id":"GO:0006956","count":1}]},{"hash":"1367510227908210327","title":"TNF/NF-kB signaling and ubiquitin-dependent degradation","description":"The GO terms cluster around TNF-mediated signaling and NF-kB activation (and regulation of JNK cascade), plus ubiquitin-dependent protein catabolic processes, all pointing to inflammatory immune signaling and proteostasis. The inclusion of V(D)J recombination supports a lymphocyte-related immune context. Overall, this seems like a TNF/NF-kB\u2013centered immune signaling cluster with ubiquitin-mediated degradation as a core process.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007250","count":3},{"id":"GO:0042787","count":3},{"id":"GO:1903265","count":3},{"id":"GO:1901253","count":3},{"id":"GO:0046328","count":3}]},{"hash":"1120103309946802148","title":"Unknown","description":"There are no GO terms or network connections to define a shared function for this cluster (edges 0, triangles 0, max degree 0), so a meaningful label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2203563359746260768","title":"Unknown","description":"The top terms span mammalian development (prostate gland development, male sex differentiation) and immune signaling (type I interferon response), plus diverse metabolic and biosynthetic processes (steroid receptor assembly, bacterial ectoine metabolism, fungal verruculogen biosynthesis, fatty acid oxidation, xanthine catabolism). The terms don\u2019t converge on a single function for this small protein set, and there are no network connections, so a meaningful, confident label cannot be assigned.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030850","count":1},{"id":"GO:0071357","count":1},{"id":"GO:0046661","count":1},{"id":"GO:0006463","count":1},{"id":"GO:0097089","count":1}]},{"hash":"2281683377878804811","title":"Cardiac signaling and calcium transport","description":"The top GO terms cluster around heart-related functions: Purkinje myocyte to ventricular cardiac muscle signaling, outflow tract morphogenesis, and positive regulation of calcium transporter activity, suggesting a cardiac signaling and calcium handling theme. While a few terms are unrelated (e.g., membrane repair and some obsolete terms), the strongest common thread appears to be cardiomyocyte signaling and calcium homeostasis, with some ancillary growth or maintenance terms. ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0030433","count":1},{"id":"GO:0043569","count":1},{"id":"GO:0001778","count":1},{"id":"GO:0051092","count":1},{"id":"GO:0071313","count":1}]},{"hash":"1707037729446121989","title":"Unknown","description":"The listed GO terms span vascular development, immune differentiation, synaptic organization, receptor clustering, behavior, drug response, kidney development, and pregnancy-related processes, with no clear single theme tying the proteins together. Therefore no cohesive function can be assigned to this cluster; label Unknown with None.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0061156","count":1},{"id":"GO:0002315","count":1},{"id":"GO:0097116","count":1},{"id":"GO:0043113","count":1},{"id":"GO:2000821","count":1}]},{"hash":"2109861612754527870","title":"Carbohydrate Metabolism and Transcriptional Regulation","description":"The cluster shows several carbohydrate-related metabolic terms (galactose, sorbitol biosynthesis, inositol catabolic process) alongside regulatory terms (negative regulation of transcription by RNA polymerase II, negative regulation of kinase activity), suggesting proteins tied to metabolic regulation and transcriptional control. Some terms are obsolete, which makes the link tentative but still points to a metabolic-regulatory theme.","confidence":"Low","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0000122","count":2},{"id":"GO:0006061","count":2},{"id":"GO:0043433","count":2},{"id":"GO:0009089","count":2},{"id":"GO:0019310","count":2}]},{"hash":"66883402366327702","title":"Unknown","description":"The GO terms cover a highly diverse set of processes (skin development, bone remodeling, dopamine uptake, vesicle trafficking, copper homeostasis, phosphorylation signaling, immune cell aggregation, oligodendrocyte differentiation, lysosomal organization, and inhibition of excitatory signaling), with no single cohesive function standing out. This makes it difficult to assign a specific, representative label to the cluster.","confidence":"","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0060789","count":1},{"id":"GO:0045453","count":1},{"id":"GO:0051586","count":1},{"id":"GO:0048194","count":1},{"id":"GO:0006878","count":1}]},{"hash":"1851170338147923525","title":"Cell cycle and stress signaling","description":"The terms point to cell cycle (GO:0007049) and stress-related signaling (mechanical stimulus response, JNK cascade) with ubiquitination, suggesting a functional cluster where cell-cycle regulation is intertwined with stress signaling and protein turnover.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007049","count":2},{"id":"GO:0071260","count":2},{"id":"GO:0016567","count":2},{"id":"GO:0061408","count":2},{"id":"GO:0046330","count":1}]},{"hash":"947475910686838444","title":"Mitotic Cell Cycle and Chromatin Modification","description":"This cluster is enriched for GO terms tied to cell division and mitosis (mitotic cell cycle, anaphase-promoting complex\u2013dependent catabolic process, general cell division) and chromatin-related regulation (histone H3-K79 methylation, ubiquitination). The combination suggests proteins involved in coordinating chromosome segregation with chromatin modification and proteostasis during mitosis. A few terms like unfolded-protein response or cadmium response are present but secondary to the dominant mitotic/chromatin pattern.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2001162","count":2},{"id":"GO:0070979","count":2},{"id":"GO:0051301","count":2},{"id":"GO:0071276","count":2},{"id":"GO:0000278","count":2}]},{"hash":"607686768395891254","title":"Lipid Biosynthesis and Lipid-Linked Differentiation","description":"This cluster\u2019s GO terms cluster around lipid-related processes: unsaturated fatty acid biosynthesis, ergosterol biosynthesis regulation, and MIPC metabolism indicate lipid metabolism, while CNS myelin maintenance and sebaceous gland differentiation reflect lipid-rich tissues and lipid-driven differentiation. A few terms (nitric oxide/nitrate metabolism, mitochondrial inheritance) are more general, but they don\u2019t override the dominant lipid theme.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0006636","count":3},{"id":"GO:0032286","count":3},{"id":"GO:0006675","count":3},{"id":"GO:0000001","count":3},{"id":"GO:0032443","count":3}]},{"hash":"726103720717943818","title":"Unknown","description":"No GO terms are provided and the network has no connections, so there is no shared functional signal to tie these proteins together. Consequently, I cannot assign a meaningful label beyond Unknown.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"2005676167609143756","title":"Immune cell differentiation and signaling","description":"Top GO terms are dominated by immune-related processes, including positive regulation of T cell differentiation (gamma-delta and alpha-beta), regulation of leukocyte chemotaxis, and innate immune response, along with signaling events such as erythropoietin-mediated signaling and STAT phosphorylation. Although a less related term (vagina development) appears, the overall pattern points to immunomodulatory functions and control of immune cell maturation and trafficking, suggesting the proteins in this cluster participate in immune signaling rather than a structural role.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0045588","count":2},{"id":"GO:0001954","count":2},{"id":"GO:0002688","count":2},{"id":"GO:0038162","count":2},{"id":"GO:0060068","count":2}]},{"hash":"1894768791141762470","title":"COPI-Mediated ER-Golgi Transport","description":"The top GO terms cluster around COPI vesicle coating and ER-to-Golgi trafficking (COPI coating of Golgi vesicle, COPI-coated vesicle budding, ER-to-Golgi vesicle-mediated transport, protein retention in ER lumen, and regulation of ER exit). These collectively indicate a function focused on COPI-mediated transport between the ER and Golgi and ER cargo retention. A few outlier terms related to development or behavior appear incidental and do not override the dominant ER-Golgi trafficking theme.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048205","count":2},{"id":"GO:0035964","count":2},{"id":"GO:0006621","count":2},{"id":"GO:0006888","count":2},{"id":"GO:0070863","count":2}]},{"hash":"1749445645205481254","title":"Fatty acid metabolism","description":"The top GO terms cluster around fatty acid metabolic processes (long-, medium-, very long-chain) and related CoA handling/transport, with ancillary lipid biosynthesis terms (bile acid metabolism, lipoteichoic acid biosynthesis) and a seed coat development term that likely reflects lipid deposition. Together these terms point to a lipid/fatty-acid metabolism theme rather than a single narrow pathway.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010214","count":1},{"id":"GO:0001676","count":1},{"id":"GO:0036112","count":1},{"id":"GO:0015911","count":1},{"id":"GO:0008206","count":1}]},{"hash":"865265840653641134","title":"Endosomal vesicle formation and cell cycle","description":"Based on the GO terms, the cluster clusters around endosomal/vesicular trafficking (intralumenal vesicle formation, multivesicular body assembly, endosome transport, Golgi retention) with an additional tie to mitotic/cell cycle processes (nuclear membrane reassembly, regulation of spindle assembly, cell division). The primary theme is endosomal vesicle formation and trafficking, with a secondary association to cell cycle events.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0070676","count":1},{"id":"GO:1901673","count":1},{"id":"GO:0045053","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0007049","count":1}]},{"hash":"966940292307411889","title":"Vascular remodeling and ECM dynamics","description":"GO terms cluster around regulation of angiogenesis, VEGF signaling, hyaluronan metabolism, extracellular matrix assembly, and blood coagulation, pointing to processes governing vascular development and ECM remodeling. Immune signaling (T cell activation) and axon guidance appear as related contexts within this mix, suggesting cross-talk between vasculature, ECM, and immune pathways. Overall, the common thread is vascular remodeling with ECM interactions rather than a single enzymatic function.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0016525","count":2},{"id":"GO:0006511","count":1},{"id":"GO:0033564","count":1},{"id":"GO:0043569","count":1},{"id":"GO:1900748","count":1}]},{"hash":"1675898386952874926","title":"Unknown","description":"The cluster has no shared GO terms or connections (no edges, triangles, or top terms), so there is no evident common function to label. Without functional signals, the appropriate label is Unknown with no confidence.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[]},{"hash":"191439705352080311","title":"Cartilage ECM remodeling and cell adhesion","description":"GO terms indicate extracellular matrix remodeling and cartilage development (growth plate chondrocyte morphogenesis, hyaluronan metabolism, negative regulation of ECM assembly, metallopeptidase activity) together with cell adhesion and signaling (integrin-mediated signaling, protein heterotrimerization) and immune-related processes (blood coagulation, T cell activation, extravasation). This suggests a cohesive theme of ECM remodeling in cartilage with associated cell adhesion and immune interactions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0003429","count":2},{"id":"GO:0045123","count":2},{"id":"GO:0030212","count":2},{"id":"GO:1901202","count":2},{"id":"GO:0070208","count":2}]},{"hash":"972062942108079532","title":"ABA signaling and seed dormancy regulation","description":"These GO terms converge on abscisic acid (ABA) signaling and seed dormancy maintenance, including positive regulation of ABA signaling, suggesting the proteins participate in ABA-mediated control of seed dormancy.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0009738","count":1},{"id":"GO:0010231","count":1},{"id":"GO:0009789","count":1}]},{"hash":"226101162322836783","title":"Unknown","description":"The GO terms span very diverse processes, including TNF signaling, NF-kappaB regulation, DNA damage checkpoint signaling, endosome transport, and development, with no clear shared function among the three proteins. With zero edges and only one count per term, there isn't a coherent theme to assign, so Unknown is most appropriate.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:2000009","count":1},{"id":"GO:0048227","count":1},{"id":"GO:1902072","count":1},{"id":"GO:1902306","count":1},{"id":"GO:0032088","count":1}]},{"hash":"2124212075621313156","title":"Nuclear transcription initiation and development","description":"This cluster centers on nuclear transcription processes (DNA-templated transcription initiation, RNA Pol II preinitiation complex assembly) and transcriptional regulation (Notch target transcription) with supportive links to development (multicellular organism development, inner cell mass proliferation) and RNA processing (snoRNP assembly). The shared theme appears to be regulation of gene expression in the context of development, so a concise label emphasizing transcription initiation within developmental biology fits well.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0051457","count":1},{"id":"GO:0030307","count":1},{"id":"GO:0032435","count":1},{"id":"GO:0001833","count":1},{"id":"GO:0007221","count":1}]},{"hash":"1350971918424814934","title":"Integrin-driven adhesion and migration","description":"The top GO terms converge on integrin-mediated adhesion, receptor clustering, and various cell migrations (fibroblasts, smooth muscle), plus related signaling and axon guidance. This points to a cohesive theme of integrin-dependent adhesion signaling coordinating cell movement during development and morphogenesis.","confidence":"High","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0048842","count":3},{"id":"GO:0007161","count":3},{"id":"GO:0014909","count":3},{"id":"GO:0043113","count":2},{"id":"GO:0007229","count":2}]},{"hash":"1653590984720576211","title":"Diverse stimulus-response signaling cluster","description":"Top GO terms indicate responses to glucose, prostaglandin, osmotic stress, and chemotactic signaling, along with MAPK cascade and apoptotic regulation, plus some adhesion and development terms. This mix suggests a broad signaling and stress-response theme rather than a single, cohesive pathway, justifying a general stimulus-response signaling label.","confidence":"Medium","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":"mitotic cell cycle","top_go_terms":[{"id":"GO:0071333","count":3},{"id":"GO:0001954","count":3},{"id":"GO:0002688","count":3},{"id":"GO:0000196","count":3},{"id":"GO:0060068","count":3}]},{"hash":"1787727927906423973","title":"GPCR Signaling and Blood Pressure Regulation","description":"This cluster\u2019s top GO terms are dominated by adenylate cyclase-activating GPCR signaling, including dopamine receptor signaling, and processes governing blood pressure and renin secretion, pointing to a coherent theme of GPCR-mediated signaling coordinating cardiovascular homeostasis. Additional terms for Rho signaling, prostaglandin response, and peptide responses support broader cell signaling and regulatory functions, while the electron transport chain term is less central. Overall, GPCR signaling with cardiovascular regulation best captures the shared functions.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0010579","count":3},{"id":"GO:0022900","count":3},{"id":"GO:0035025","count":3},{"id":"GO:0045777","count":3},{"id":"GO:0007191","count":2}]},{"hash":"810553347703378278","title":"Dopaminergic GPCR Signaling","description":"The top GO terms point strongly to dopamine receptor\u2013mediated GPCR signaling, including the adenylate cyclase\u2013activating dopamine pathway and regulation of dopamine uptake. Additional terms touch on GPCR-related processes such as prostaglandin response and GTPase activity, suggesting a common theme of dopaminergic signaling and downstream GPCR modulation, even though some terms are more peripheral (e.g., renin secretion, astrocyte chemotaxis). ","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0007191","count":1},{"id":"GO:1900135","count":1},{"id":"GO:2000458","count":1},{"id":"GO:1901652","count":1},{"id":"GO:0018298","count":1}]},{"hash":"930447363923066567","title":"MAPK/ERK and insulin signaling regulators in neural development","description":"The cluster\u2019s top GO terms heavily emphasize regulation of MAPK/ERK signaling and insulin receptor signaling, along with neural development processes like cerebellar cortex formation, Bergmann glial differentiation, and axon regeneration. While immune signaling terms (T cell receptor pathways) appear, the strongest cohesive theme centers on signaling regulation\u2014especially MAPK/ERK and insulin pathways\u2014in neural development contexts.","confidence":"Medium","size":3,"edges":3,"triangles":1,"max_degree":2,"top_function":null,"top_go_terms":[{"id":"GO:0070373","count":2},{"id":"GO:0008286","count":2},{"id":"GO:0021697","count":2},{"id":"GO:0060020","count":2},{"id":"GO:0050852","count":2}]},{"hash":"186665721875496546","title":"Neural signaling and sensory perception","description":"Based on the top GO terms, the proteins are linked to neural signaling and sensory processing: dopaminergic synaptic transmission, visual perception and learning, sensory perception of pain, and cocaine-related behavioral responses, with ERK1/ERK2 cascade regulation supporting signal transduction. A few terms (macrophage chemotaxis, heart development) are less tied to neural function, likely reflecting multifunctionality. Overall, the dominant theme is neural signaling and sensory perception, giving a reasonable, but not certain, label.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0071380","count":3},{"id":"GO:0001963","count":3},{"id":"GO:0007601","count":3},{"id":"GO:0010759","count":3},{"id":"GO:0048148","count":3}]},{"hash":"231606669961095466","title":"Unknown","description":"Top terms are not provided for this cluster, so there is no identifiable shared function among the three proteins. With no GO terms or functional signals, a meaningful label cannot be assigned; thus Unknown with confidence None.","confidence":"","size":3,"edges":2,"triangles":0,"max_degree":2,"top_function":null,"top_go_terms":[]},{"hash":"1021576979733839885","title":"Tissue Morphogenesis","description":"This cluster is dominated by GO terms involving morphogenesis across tissues (skin morphogenesis, skin development, camera-type eye morphogenesis, cuticle development). Those terms point to a common theme of tissue/organ formation and shaping. A few terms relate to DNA metabolism or lipid-related processes that are less directly tied to morphogenesis, but overall the connected set centers on developmental tissue formation.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0006259","count":1},{"id":"GO:0060355","count":1},{"id":"GO:1903225","count":1},{"id":"GO:0090305","count":1},{"id":"GO:0010743","count":1}]},{"hash":"1470496367987567290","title":"ECM Remodeling and Inflammation","description":"The GO terms show strong signals for extracellular matrix organization (fibronectin fibril organization) and cell adhesion/integrin signaling, plus processes related to endocytosis and immune/inflammatory responses (acute inflammatory response to antigenic stimulus, negative regulation of IL-8 production, apoptotic cell clearance). There are also proteolytic-related activities (zymogen activation, protein deamination) that can accompany ECM remodeling. Taken together, these terms point to a cluster involved in remodeling the extracellular matrix in the context of inflammatory signaling and proteolytic processing.","confidence":"Medium","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:1905590","count":3},{"id":"GO:0006898","count":3},{"id":"GO:2000483","count":3},{"id":"GO:0032332","count":3},{"id":"GO:0031638","count":3}]},{"hash":"436655453788073339","title":"Unknown","description":"GO terms are highly diverse and include lipopolysaccharide metabolism, unfolded protein response, retinal photoreceptor outer segment localization, cell division, centrosome maintenance, and several obsolete terms. There is no clear shared function or pathway linking these proteins, making a coherent label difficult.","confidence":"","size":3,"edges":0,"triangles":0,"max_degree":0,"top_function":null,"top_go_terms":[{"id":"GO:0008653","count":1},{"id":"GO:0006986","count":1},{"id":"GO:1903546","count":1},{"id":"GO:0051301","count":1},{"id":"GO:0051661","count":1}]},{"hash":"606338031350032004","title":"Neuronal signaling and behavior","description":"Based on the GO terms, the cluster centers on nervous system activity and behavior: serotonin receptor signaling, calcium ion transport linked to electrophysiology, action potential and inhibitory postsynaptic potentials, and behavioral responses (walking, nicotine response). Additional terms about sensory detection and neural processing align with neural signaling, while a couple of terms touch on development and growth, but the dominant theme is neuronal signaling and behavioral functions.","confidence":"Medium","size":3,"edges":1,"triangles":0,"max_degree":1,"top_function":null,"top_go_terms":[{"id":"GO:0098703","count":2},{"id":"GO:0007210","count":2},{"id":"GO:0060112","count":2},{"id":"GO:0003428","count":2},{"id":"GO:0050910","count":2}]}]