format-version: 1.2 date: 04:08:2010 09:34 auto-generated-by: OBO-Edit 2.0 subsetdef: goslim_candida "Candida GO slim" subsetdef: goslim_generic "Generic GO slim" subsetdef: goslim_goa "GOA and proteome slim" subsetdef: goslim_pir "PIR GO slim" subsetdef: goslim_plant "Plant GO slim" subsetdef: goslim_pombe "Fission yeast GO slim" subsetdef: goslim_yeast "Yeast GO slim" subsetdef: gosubset_prok "Prokaryotic GO subset" subsetdef: unvetted "unvetted" synonymtypedef: systematic_synonym "Systematic synonym" EXACT default-namespace: gene_ontology remark: cvs version: $Revision: 1.1359 $ [Term] id: GO:0000001 name: mitochondrion inheritance namespace: biological_process def: "The distribution of mitochondria, including the mitochondrial genome, into daughter cells after mitosis or meiosis, mediated by interactions between mitochondria and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:11389764] synonym: "mitochondrial inheritance" EXACT [] is_a: GO:0048308 ! organelle inheritance is_a: GO:0048311 ! mitochondrion distribution [Term] id: GO:0000002 name: mitochondrial genome maintenance namespace: biological_process def: "The maintenance of the structure and integrity of the mitochondrial genome; includes replication and segregation of the mitochondrial chromosome." [GOC:ai, GOC:vw] is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0000003 name: reproduction namespace: biological_process alt_id: GO:0019952 alt_id: GO:0050876 def: "The production by an organism of new individuals that contain some portion of their genetic material inherited from that organism." [GOC:go_curators, GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "reproductive physiological process" EXACT [] xref: Wikipedia:Reproduction is_a: GO:0008150 ! biological_process [Term] id: GO:0000005 name: ribosomal chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct assembly of ribosomes or ribosomal subunits in vivo, but is not a component of the assembled ribosome when performing its normal biological function." [GOC:jl, PMID:12150913] comment: This term was made obsolete because it refers to a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0042254 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0000006 name: high affinity zinc uptake transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+(out) = Zn2+(in), probably powered by proton motive force. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [TC:2.A.5.1.1] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000007 name: low-affinity zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Zn2+ = Zn2+, probably powered by proton motive force. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005385 ! zinc ion transmembrane transporter activity [Term] id: GO:0000008 name: thioredoxin namespace: molecular_function alt_id: GO:0000013 def: "OBSOLETE. A small disulfide-containing redox protein that serves as a general protein disulfide oxidoreductase. Interacts with a broad range of proteins by a redox mechanism, based on the reversible oxidation of 2 cysteine thiol groups to a disulfide, accompanied by the transfer of 2 electrons and 2 protons. The net result is the covalent interconversion of a disulfide and a dithiol." [GOC:kd] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0006467 consider: GO:0015036 [Term] id: GO:0000009 name: alpha-1,6-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,6-linkage." [GOC:mcc, PMID:2644248] xref: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000010 name: trans-hexaprenyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-hexaprenyl diphosphate + isopentenyl diphosphate = diphosphate + all-trans-heptaprenyl diphosphate." [EC:2.5.1.30] subset: gosubset_prok synonym: "all-trans-heptaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "all-trans-hexaprenyl-diphosphate:isopentenyl-diphosphate hexaprenyltranstransferase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl diphosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.30] synonym: "heptaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.30] xref: EC:2.5.1.30 xref: MetaCyc:TRANS-HEXAPRENYLTRANSTRANSFERASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0000011 name: vacuole inheritance namespace: biological_process def: "The distribution of vacuoles into daughter cells after mitosis or meiosis, mediated by interactions between vacuoles and the cytoskeleton." [GOC:mcc, PMID:10873824, PMID:14616069] is_a: GO:0007033 ! vacuole organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0000012 name: single strand break repair namespace: biological_process def: "The repair of single strand breaks in DNA. Repair of such breaks is mediated by the same enzyme systems as are used in base excision repair." [http://www.ultranet.com/~jkimball/BiologyPages/D/DNArepair.html] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000014 name: single-stranded DNA specific endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within a single-stranded deoxyribonucleic acid molecule by creating internal breaks." [GOC:mah] synonym: "ssDNA-specific endodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0000015 name: phosphopyruvate hydratase complex namespace: cellular_component def: "A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "enolase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000016 name: lactase activity namespace: molecular_function def: "Catalysis of the reaction: lactose + H2O = D-glucose + D-galactose." [EC:3.2.1.108] synonym: "lactase-phlorizin hydrolase activity" BROAD [EC:3.2.1.108] synonym: "lactose galactohydrolase activity" EXACT [EC:3.2.1.108] xref: EC:3.2.1.108 xref: MetaCyc:LACTASE-RXN xref: Reactome:20536 "lactase activity" is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0000017 name: alpha-glucoside transport namespace: biological_process def: "The directed movement of alpha-glucosides into, out of, within or between cells by means of some external agent such as a transporter or pore. Alpha-glucosides are glycosides in which the sugar moiety is a glucose residue, and the anomeric carbon of the bond is in an alpha configuration." [GOC:jl, http://www.biochem.purdue.edu/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0042946 ! glucoside transport [Term] id: GO:0000018 name: regulation of DNA recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination, a process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006310 ! DNA recombination relationship: regulates GO:0006310 ! DNA recombination [Term] id: GO:0000019 name: regulation of mitotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA recombination during mitosis." [GOC:go_curators] synonym: "regulation of recombination within rDNA repeats" NARROW [] is_a: GO:0000018 ! regulation of DNA recombination intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006312 ! mitotic recombination relationship: regulates GO:0006312 ! mitotic recombination [Term] id: GO:0000020 name: negative regulation of recombination within rDNA repeats namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of genetic recombination within the DNA of the genes coding for ribosomal RNA." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a substrate-specific process. is_obsolete: true consider: GO:0045950 [Term] id: GO:0000022 name: mitotic spindle elongation namespace: biological_process def: "Lengthening of the distance between poles of the mitotic spindle." [GOC:mah] synonym: "spindle elongation during mitosis" EXACT [] is_a: GO:0051231 ! spindle elongation relationship: part_of GO:0007052 ! mitotic spindle organization [Term] id: GO:0000023 name: maltose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose), an intermediate in the catabolism of glycogen and starch." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar metabolic process" EXACT [] synonym: "malt sugar metabolism" EXACT [] synonym: "maltose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0000024 name: maltose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar biosynthesis" EXACT [] synonym: "malt sugar biosynthetic process" EXACT [] synonym: "maltose anabolism" EXACT [] synonym: "maltose biosynthesis" EXACT [] synonym: "maltose formation" EXACT [] synonym: "maltose synthesis" EXACT [] is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0000025 name: maltose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the disaccharide maltose (4-O-alpha-D-glucopyranosyl-D-glucopyranose)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malt sugar catabolic process" EXACT [] synonym: "malt sugar catabolism" EXACT [] synonym: "maltose breakdown" EXACT [] synonym: "maltose degradation" EXACT [] synonym: "maltose hydrolysis" NARROW [] xref: MetaCyc:MALTOSECAT-PWY is_a: GO:0000023 ! maltose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0000026 name: alpha-1,2-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,2-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000027 name: ribosomal large subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit." [GOC:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly relationship: part_of GO:0042273 ! ribosomal large subunit biogenesis [Term] id: GO:0000028 name: ribosomal small subunit assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the small ribosomal subunit." [GOC:jl] subset: gosubset_prok is_a: GO:0042257 ! ribosomal subunit assembly relationship: part_of GO:0042274 ! ribosomal small subunit biogenesis [Term] id: GO:0000030 name: mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- xref: Reactome:7672 "mannosyltransferase activity" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0000031 name: mannosylphosphate transferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannosylphosphate group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0000032 name: cell wall mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall mannoproteins, any cell wall protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [GOC:ai] subset: gosubset_prok synonym: "cell wall mannoprotein anabolism" EXACT [] synonym: "cell wall mannoprotein biosynthesis" EXACT [] synonym: "cell wall mannoprotein formation" EXACT [] synonym: "cell wall mannoprotein synthesis" EXACT [] is_a: GO:0006057 ! mannoprotein biosynthetic process is_a: GO:0031506 ! cell wall glycoprotein biosynthetic process [Term] id: GO:0000033 name: alpha-1,3-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a mannose residue from GDP-mannose to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:mcc, PMID:10521541] xref: EC:2.4.1.- is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0000034 name: adenine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenine + H2O = hypoxanthine + NH3." [EC:3.5.4.2] subset: gosubset_prok synonym: "ADase activity" EXACT [EC:3.5.4.2] synonym: "adenase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminase activity" EXACT [EC:3.5.4.2] synonym: "adenine aminohydrolase activity" EXACT [EC:3.5.4.2] xref: EC:3.5.4.2 xref: MetaCyc:ADENINE-DEAMINASE-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0000035 name: acyl binding namespace: molecular_function def: "Interacting selectively and non-covalently with an acyl group, any group formally derived by removal of the hydroxyl group from the acid function of a carboxylic acid." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0000036 name: acyl carrier activity namespace: molecular_function def: "Enables the directed movement of acyl groups into, out of, within or between cells." [ChEBI:22221, GOC:cb] subset: gosubset_prok is_a: GO:0022892 ! substrate-specific transporter activity [Term] id: GO:0000038 name: very long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids with a chain length of C18 or greater." [GOC:hjd] subset: gosubset_prok synonym: "very-long-chain fatty acid metabolic process" EXACT [] synonym: "very-long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0000039 name: plasma membrane long-chain fatty acid transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product and it contains component information. is_obsolete: true consider: GO:0005324 consider: GO:0005886 [Term] id: GO:0000040 name: low-affinity iron ion transport namespace: biological_process def: "The directed, low-affinity movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] synonym: "low affinity iron ion transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0000041 name: transition metal ion transport namespace: biological_process def: "The directed movement of transition metal ions into, out of, within or between cells by means of some external agent such as a transporter or pore. A transition metal is an element whose atom has an incomplete d-subshell of extranuclear electrons, or which gives rise to a cation or cations with an incomplete d-subshell. Transition metals often have more than one valency state. Biologically relevant transition metals include vanadium, manganese, iron, copper, cobalt, nickel, molybdenum and silver." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "transition metal transport" EXACT [] is_a: GO:0030001 ! metal ion transport [Term] id: GO:0000042 name: protein targeting to Golgi namespace: biological_process def: "The process of directing proteins towards the Golgi; usually uses signals contained within the protein." [GOC:ai, GOC:mah] synonym: "protein-Golgi targeting" EXACT [] is_a: GO:0000301 ! retrograde transport, vesicle recycling within Golgi is_a: GO:0006605 ! protein targeting relationship: part_of GO:0034067 ! protein localization in Golgi apparatus [Term] id: GO:0000044 name: ascorbate stabilization namespace: biological_process def: "OBSOLETE. The reduction of the ascorbate free radical to a stable form." [GOC:ai, GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. synonym: "vitamin C stabilization" EXACT [] is_obsolete: true [Term] id: GO:0000045 name: autophagic vacuole assembly namespace: biological_process def: "The formation of a double membrane-bounded structure, the autophagosome, that occurs when a specialized membrane sac, called the isolation membrane, starts to enclose a portion of the cytoplasm." [PMID:9412464] synonym: "autophagic vacuole formation" RELATED [GOC:mah] synonym: "autophagosome biosynthesis" EXACT [] synonym: "autophagosome formation" EXACT [] synonym: "PAS formation" NARROW [] is_a: GO:0007033 ! vacuole organization is_a: GO:0070925 ! organelle assembly relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000046 name: autophagic vacuole fusion namespace: biological_process def: "The fusion of an autophagic vacuole with a vacuole (yeast) or lysosome (e.g. mammals and insects). In the case of yeast, inner membrane-bounded structures (autophagic bodies) appear in the vacuole." [PMID:11099404] synonym: "fusion of autophagosome with lysosome" NARROW [] is_a: GO:0048284 ! organelle fusion is_a: GO:0090174 ! organelle membrane fusion relationship: part_of GO:0016236 ! macroautophagy [Term] id: GO:0000047 name: Rieske iron-sulfur protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "Rieske iron-sulphur protein" EXACT [] is_obsolete: true consider: GO:0009055 [Term] id: GO:0000048 name: peptidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-tRNA(1) + aminoacyl-tRNA(2) = tRNA(1) + peptidylaminoacyl-tRNA(2)." [EC:2.3.2.12, PMID:11433365, PMID:9242921] synonym: "peptidyl-tRNA:aminoacyl-tRNA N-peptidyltransferase activity" EXACT [EC:2.3.2.12] xref: EC:2.3.2.12 xref: MetaCyc:PEPTIDYLTRANSFERASE-RXN xref: Reactome:20610 "peptidyltransferase activity" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0000049 name: tRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with transfer RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0000050 name: urea cycle namespace: biological_process alt_id: GO:0006594 alt_id: GO:0006871 def: "A cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ornithine cycle" EXACT [] synonym: "urea biosynthesis" EXACT [] synonym: "urea biosynthetic process" EXACT [] xref: Reactome:562580 "Urea cycle" xref: Reactome:588206 "Urea cycle" xref: Reactome:608967 "Urea cycle" xref: Reactome:633649 "Urea cycle" xref: Reactome:645277 "Urea cycle" xref: Reactome:655654 "Urea cycle" xref: Reactome:660929 "Urea cycle" xref: Reactome:666704 "Urea cycle" xref: Reactome:672800 "Urea cycle" xref: Reactome:678524 "Urea cycle" xref: Reactome:683480 "Urea cycle" xref: Reactome:689684 "Urea cycle" xref: Reactome:701420 "Urea cycle" xref: Reactome:70635 "Urea cycle" xref: Reactome:715991 "Urea cycle" xref: Reactome:720736 "Urea cycle" xref: Reactome:727938 "Urea cycle" xref: Reactome:730910 "Urea cycle" xref: Reactome:732996 "Urea cycle" xref: Reactome:733842 "Urea cycle" xref: Reactome:735550 "Urea cycle" xref: Reactome:736531 "Urea cycle" xref: Reactome:738460 "Urea cycle" xref: Wikipedia:Urea_cycle is_a: GO:0019627 ! urea metabolic process is_a: GO:0043604 ! amide biosynthetic process [Term] id: GO:0000051 name: urea cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving any of the intermediate compounds involved in the urea cycle, a cyclic metabolic pathway that converts waste nitrogen in the form of ammonium to urea." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. subset: gosubset_prok synonym: "urea cycle intermediate metabolism" EXACT [] is_obsolete: true [Term] id: GO:0000052 name: citrulline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrulline, N5-carbamoyl-L-ornithine, an alpha amino acid not found in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrulline metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006575 ! cellular amino acid derivative metabolic process [Term] id: GO:0000053 name: argininosuccinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving argininosuccinate, 2-(N(omega)-arginino)succinate, an intermediate in the ornithine-urea cycle, where it is synthesized from citrulline and aspartate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "argininosuccinate metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0000054 name: ribosomal subunit export from nucleus namespace: biological_process def: "The directed movement of a ribosomal subunit from the nucleus into the cytoplasm." [GOC:ai] synonym: "ribosomal subunit export from cell nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit export out of nucleus" EXACT [GOC:mah] synonym: "ribosomal subunit transport from nucleus to cytoplasm" EXACT [GOC:mah] synonym: "ribosomal subunit-nucleus export" EXACT [GOC:mah] synonym: "ribosome export from nucleus" RELATED [GOC:mah, GOC:rb] is_a: GO:0033753 ! establishment of ribosome localization is_a: GO:0051168 ! nuclear export relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0000055 name: ribosomal large subunit export from nucleus namespace: biological_process alt_id: GO:0000057 def: "The directed movement of a ribosomal large subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "ribosomal large subunit export from cell nucleus" EXACT [] synonym: "ribosomal large subunit export out of nucleus" EXACT [] synonym: "ribosomal large subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal large subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000056 name: ribosomal small subunit export from nucleus namespace: biological_process alt_id: GO:0000058 def: "The directed movement of a ribosomal small subunit from the nucleus into the cytoplasm." [GOC:mah] synonym: "ribosomal small subunit export from cell nucleus" EXACT [] synonym: "ribosomal small subunit export out of nucleus" EXACT [] synonym: "ribosomal small subunit transport from nucleus to cytoplasm" EXACT [] synonym: "ribosomal small subunit-nucleus export" EXACT [] is_a: GO:0000054 ! ribosomal subunit export from nucleus [Term] id: GO:0000059 name: protein import into nucleus, docking namespace: biological_process def: "The aggregation, arrangement and bonding together of the nuclear localization signal of a protein with nuclear envelope proteins such as importins." [GOC:isa_complete, PMID:7878057] synonym: "protein docking during protein import into nucleus" EXACT [] synonym: "protein docking during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein docking during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, docking" EXACT [] synonym: "protein-nucleus import, docking" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000060 name: protein import into nucleus, translocation namespace: biological_process def: "The vectorial transfer of a protein from the cytoplasm into the nucleus, through the nuclear pore and across the nuclear envelope." [GOC:jl, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "protein import into cell nucleus, translocation" EXACT [] synonym: "protein translocation during protein import into nucleus" EXACT [] synonym: "protein translocation during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein translocation during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, translocation" EXACT [] synonym: "protein-nucleus import, translocation" EXACT [] is_a: GO:0006886 ! intracellular protein transport relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000061 name: protein import into nucleus, substrate release namespace: biological_process def: "The disaggregation of a protein complex composed of the nuclear localization sequence and the importin alpha, and importin beta proteins." [PMID:9687515] synonym: "protein import into cell nucleus, substrate release" EXACT [] synonym: "protein substrate release during protein import into nucleus" EXACT [] synonym: "protein substrate release during protein transport from cytoplasm to nucleus" EXACT [] synonym: "protein substrate release during protein-nucleus import" EXACT [] synonym: "protein transport from cytoplasm to nucleus, substrate release" EXACT [] synonym: "protein-nucleus import, substrate release" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006606 ! protein import into nucleus [Term] id: GO:0000062 name: acyl-CoA binding namespace: molecular_function def: "Interacting selectively and non-covalently with acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA or acyl binding" BROAD [] is_a: GO:0005504 ! fatty acid binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0000064 name: L-ornithine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-ornithine from one side of a membrane to the other. L-ornithine is 2,5-diaminopentanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" RELATED [] synonym: "L-ornithine transporter activity" BROAD [] xref: Reactome:20635 "L-ornithine transmembrane transporter activity" is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015822 ! ornithine transport [Term] id: GO:0000066 name: mitochondrial ornithine transport namespace: biological_process def: "The directed movement of ornithine, 2,5-diaminopentanoic acid, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015822 ! ornithine transport [Term] id: GO:0000067 name: DNA replication and chromosome cycle namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it has been superseded by more accurate terms to represent the biological processes occurring, and it is not clear that this term represents a useful entity. is_obsolete: true consider: GO:0006260 consider: GO:0007059 consider: GO:0051276 [Term] id: GO:0000070 name: mitotic sister chromatid segregation namespace: biological_process alt_id: GO:0016359 def: "The cell cycle process whereby replicated homologous chromosomes are organized and then physically separated and apportioned to two sets during the mitotic cell cycle. Each replicated chromosome, composed of two sister chromatids, aligns at the cell equator, paired with its homologous partner. One homolog of each morphologic type goes into each of the resulting chromosome sets." [GOC:ai] synonym: "mitotic chromosome segregation" EXACT [] synonym: "mitotic sister-chromatid adhesion release" NARROW [] is_a: GO:0000819 ! sister chromatid segregation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000072 name: M phase specific microtubule process namespace: biological_process def: "A microtubule-based process that occurs only during M phase of the cell cycle." [GOC:mah] synonym: "M-phase specific microtubule process" EXACT [] is_a: GO:0007017 ! microtubule-based process relationship: part_of GO:0000279 ! M phase [Term] id: GO:0000073 name: spindle pole body separation namespace: biological_process alt_id: GO:0030475 def: "A largely uncharacterized process involving the release of duplicated spindle pole bodies (SPBs) and their migration away from each other within the nuclear membrane. Duplicated SPBs are connected by a bridge structure that may be severed in order to release the SPBs from one another. Following liberation, SPBs diffuse through the nuclear membrane until they are across from each other. SPB separation must take place in order for a bipolar mitotic spindle to assemble." [GOC:sgd_curators] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051300 ! spindle pole body organization [Term] id: GO:0000075 name: cell cycle checkpoint namespace: biological_process def: "The cell cycle regulatory process by which progression through the cycle can be halted until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, ISBN:0815316194] xref: Reactome:562759 "Cell Cycle Checkpoints" xref: Reactome:588615 "Cell Cycle Checkpoints" xref: Reactome:609115 "Cell Cycle Checkpoints" xref: Reactome:633811 "Cell Cycle Checkpoints" xref: Reactome:645581 "Cell Cycle Checkpoints" xref: Reactome:656123 "Cell Cycle Checkpoints" xref: Reactome:661257 "Cell Cycle Checkpoints" xref: Reactome:667030 "Cell Cycle Checkpoints" xref: Reactome:673178 "Cell Cycle Checkpoints" xref: Reactome:678713 "Cell Cycle Checkpoints" xref: Reactome:683635 "Cell Cycle Checkpoints" xref: Reactome:690004 "Cell Cycle Checkpoints" xref: Reactome:69620 "Cell Cycle Checkpoints" xref: Reactome:701599 "Cell Cycle Checkpoints" xref: Reactome:716184 "Cell Cycle Checkpoints" xref: Reactome:720889 "Cell Cycle Checkpoints" xref: Reactome:728134 "Cell Cycle Checkpoints" xref: Wikipedia:Cell_cycle_checkpoint is_a: GO:0051726 ! regulation of cell cycle [Term] id: GO:0000076 name: DNA replication checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that prevents the initiation of mitosis until DNA replication is complete, thereby ensuring that progeny inherit a full complement of the genome." [GOC:rn, PMID:11728327, PMID:12537518] is_a: GO:0007165 ! signal transduction is_a: GO:0031570 ! DNA integrity checkpoint is_a: GO:0032297 ! negative regulation of DNA-dependent DNA replication initiation [Term] id: GO:0000077 name: DNA damage checkpoint namespace: biological_process def: "A signal transduction pathway, induced by DNA damage, that blocks cell cycle progression (in G1, G2 or metaphase) or slows the rate at which S phase proceeds." [PMID:11891124] synonym: "DNA damage response, signal transduction resulting in cell cycle arrest" NARROW [] xref: Wikipedia:DNA_damage_checkpoint xref: Wikipedia:Postreplication_checkpoint is_a: GO:0007165 ! signal transduction is_a: GO:0031570 ! DNA integrity checkpoint is_a: GO:0042770 ! DNA damage response, signal transduction [Term] id: GO:0000078 name: cell morphogenesis checkpoint namespace: biological_process def: "A cell cycle checkpoint observed when aspects of polarity control are defective, which maintains coordination between the process of cellular morphogenesis and the nuclear events of the cell cycle. For example, in budding yeast cell-cycle delay or arrest is induced when aspects of bud formation are defective." [GOC:vw, PMID:14644188] is_a: GO:0007093 ! mitotic cell cycle checkpoint relationship: part_of GO:0000902 ! cell morphogenesis [Term] id: GO:0000079 name: regulation of cyclin-dependent protein kinase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of CDK activity." [GOC:go_curators] synonym: "regulation of CDK activity" EXACT [] is_a: GO:0045859 ! regulation of protein kinase activity is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004693 ! cyclin-dependent protein kinase activity relationship: regulates GO:0004693 ! cyclin-dependent protein kinase activity [Term] id: GO:0000080 name: G1 phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through G1 phase, one of two 'gap' phases in the mitotic cell cycle; G1 is the interval between the completion of mitosis and the beginning of DNA synthesis." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:563078 "G1 Phase" xref: Reactome:588690 "G1 Phase" xref: Reactome:609426 "G1 Phase" xref: Reactome:634126 "G1 Phase" xref: Reactome:69236 "G1 Phase" is_a: GO:0051318 ! G1 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000082 name: G1/S transition of mitotic cell cycle namespace: biological_process def: "Progression from G1 phase to S phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:562723 "G1/S Transition" xref: Reactome:588343 "G1/S Transition" xref: Reactome:609086 "G1/S Transition" xref: Reactome:633781 "G1/S Transition" xref: Reactome:645384 "G1/S Transition" xref: Reactome:655752 "G1/S Transition" xref: Reactome:660985 "G1/S Transition" xref: Reactome:666764 "G1/S Transition" xref: Reactome:672872 "G1/S Transition" xref: Reactome:678586 "G1/S Transition" xref: Reactome:683544 "G1/S Transition" xref: Reactome:689750 "G1/S Transition" xref: Reactome:69206 "G1/S Transition" xref: Reactome:701481 "G1/S Transition" xref: Reactome:716052 "G1/S Transition" xref: Reactome:720691 "G1/S Transition" xref: Reactome:728003 "G1/S Transition" xref: Reactome:730933 "G1/S Transition" xref: Reactome:733033 "G1/S Transition" xref: Reactome:733875 "G1/S Transition" xref: Reactome:735596 "G1/S Transition" xref: Reactome:738507 "G1/S Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000083 name: regulation of transcription involved in G1/S-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1/S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1/S-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter of G1/S-phase of mitotic cell cycle" RELATED [] xref: Reactome:69205 "G1/S-Specific Transcription" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000082 ! G1/S transition of mitotic cell cycle [Term] id: GO:0000084 name: S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through S phase, the part of the mitotic cell cycle during which DNA synthesis takes place." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:562903 "S Phase" xref: Reactome:588524 "S Phase" xref: Reactome:609265 "S Phase" xref: Reactome:634035 "S Phase" xref: Reactome:645520 "S Phase" xref: Reactome:655877 "S Phase" xref: Reactome:661101 "S Phase" xref: Reactome:666879 "S Phase" xref: Reactome:673001 "S Phase" xref: Reactome:678722 "S Phase" xref: Reactome:683655 "S Phase" xref: Reactome:689993 "S Phase" xref: Reactome:69242 "S Phase" xref: Reactome:701627 "S Phase" xref: Reactome:716211 "S Phase" xref: Reactome:720784 "S Phase" xref: Reactome:728160 "S Phase" xref: Reactome:731116 "S Phase" xref: Reactome:733118 "S Phase" xref: Reactome:733928 "S Phase" xref: Reactome:736604 "S Phase" xref: Reactome:738583 "S Phase" is_a: GO:0051320 ! S phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000085 name: G2 phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through G2 phase, one of two 'gap' phases in the mitotic cell cycle; G2 is the interval between the completion of DNA synthesis and the beginning of mitosis." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:563344 "G2 Phase" xref: Reactome:588959 "G2 Phase" xref: Reactome:609681 "G2 Phase" xref: Reactome:634371 "G2 Phase" xref: Reactome:645836 "G2 Phase" xref: Reactome:656157 "G2 Phase" xref: Reactome:683841 "G2 Phase" xref: Reactome:68911 "G2 Phase" xref: Reactome:690089 "G2 Phase" xref: Reactome:701840 "G2 Phase" xref: Reactome:716415 "G2 Phase" xref: Reactome:728366 "G2 Phase" is_a: GO:0051319 ! G2 phase relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000086 name: G2/M transition of mitotic cell cycle namespace: biological_process def: "Progression from G2 phase to M phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:562747 "G2/M Transition" xref: Reactome:588367 "G2/M Transition" xref: Reactome:609289 "G2/M Transition" xref: Reactome:634060 "G2/M Transition" xref: Reactome:645587 "G2/M Transition" xref: Reactome:655913 "G2/M Transition" xref: Reactome:661098 "G2/M Transition" xref: Reactome:666876 "G2/M Transition" xref: Reactome:672998 "G2/M Transition" xref: Reactome:678719 "G2/M Transition" xref: Reactome:683652 "G2/M Transition" xref: Reactome:689990 "G2/M Transition" xref: Reactome:69275 "G2/M Transition" xref: Reactome:701624 "G2/M Transition" xref: Reactome:716208 "G2/M Transition" xref: Reactome:720812 "G2/M Transition" xref: Reactome:728157 "G2/M Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000087 name: M phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the mitotic cell cycle during which mitosis takes place." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "M-phase of mitotic cell cycle" EXACT [] xref: Reactome:562807 "M Phase" xref: Reactome:588423 "M Phase" xref: Reactome:609163 "M Phase" xref: Reactome:633858 "M Phase" xref: Reactome:645443 "M Phase" xref: Reactome:655806 "M Phase" xref: Reactome:661016 "M Phase" xref: Reactome:666794 "M Phase" xref: Reactome:672905 "M Phase" xref: Reactome:678619 "M Phase" xref: Reactome:683844 "M Phase" xref: Reactome:68886 "M Phase" xref: Reactome:689775 "M Phase" xref: Reactome:720919 "M Phase" xref: Reactome:728036 "M Phase" is_a: GO:0000279 ! M phase relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0000088 name: mitotic prophase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prophase, the initial stage of mitosis in which the chromosomes are condensed but are not yet attached to a mitotic spindle." [GOC:dph, GOC:mah, ISBN:0815316194] xref: Reactome:562806 "Mitotic Prophase" xref: Reactome:588422 "Mitotic Prophase" xref: Reactome:609162 "Mitotic Prophase" xref: Reactome:633857 "Mitotic Prophase" xref: Reactome:645442 "Mitotic Prophase" xref: Reactome:655805 "Mitotic Prophase" xref: Reactome:661015 "Mitotic Prophase" xref: Reactome:666793 "Mitotic Prophase" xref: Reactome:672904 "Mitotic Prophase" xref: Reactome:678618 "Mitotic Prophase" xref: Reactome:68875 "Mitotic Prophase" xref: Reactome:689774 "Mitotic Prophase" xref: Reactome:728035 "Mitotic Prophase" is_a: GO:0051324 ! prophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000089 name: mitotic metaphase namespace: biological_process def: "Progression through metaphase, the stage of mitosis at which chromosomes are firmly attached to the mitotic spindle at its equator but have not yet segregated to opposite poles." [ISBN:0815316194] xref: Reactome:68879 "Mitotic Metaphase" is_a: GO:0051323 ! metaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000090 name: mitotic anaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase, the stage of mitosis during which the two sets of chromosomes separate and move away from each other." [GOC:dph, ISBN:0815316194] xref: Reactome:68882 "Mitotic Anaphase" is_a: GO:0051322 ! anaphase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000091 name: mitotic anaphase A namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase A, the part of mitotic anaphase in which the kinetochore microtubules shorten as chromosomes move toward the spindle poles." [GOC:dph, GOC:mah, ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000092 name: mitotic anaphase B namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase B, the part of mitotic anaphase in which the polar microtubules elongate and the two poles of the spindle move farther apart." [GOC:dph, GOC:mah, ISBN:0815316194] is_a: GO:0000090 ! mitotic anaphase [Term] id: GO:0000093 name: mitotic telophase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through telophase, the last of the stages of mitosis; in the canonical cell cycle, telophase begins when the chromosomes arrive at the poles of the cell and the division of the cytoplasm starts." [GOC:dph, GOC:mah, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0051326 ! telophase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000094 name: septin assembly and septum formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined and the string name implied two separate processes. is_obsolete: true consider: GO:0000917 consider: GO:0000918 consider: GO:0000921 [Term] id: GO:0000095 name: S-adenosylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015177 def: "Catalysis of the transfer of S-adenosylmethionine from one side of a membrane to the other. S-adenosylmethionine is S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:ai] synonym: "S-adenosyl methionine permease activity" EXACT [] synonym: "S-adenosyl methionine transporter activity" EXACT [] synonym: "S-adenosylmethionine permease activity" EXACT [] synonym: "S-adenosylmethionine transporter activity" BROAD [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity is_a: GO:0051184 ! cofactor transporter activity relationship: part_of GO:0015805 ! S-adenosylmethionine transport [Term] id: GO:0000096 name: sulfur amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing sulfur, comprising cysteine, homocysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid metabolism" EXACT [] synonym: "sulphur amino acid metabolic process" EXACT [] synonym: "sulphur amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006790 ! sulfur metabolic process [Term] id: GO:0000097 name: sulfur amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid anabolism" EXACT [] synonym: "sulfur amino acid biosynthesis" EXACT [] synonym: "sulfur amino acid formation" EXACT [] synonym: "sulfur amino acid synthesis" EXACT [] synonym: "sulphur amino acid biosynthesis" EXACT [] synonym: "sulphur amino acid biosynthetic process" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0000098 name: sulfur amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing sulfur, comprising cysteine, methionine and selenocysteine." [GOC:ai] subset: gosubset_prok synonym: "sulfur amino acid breakdown" EXACT [] synonym: "sulfur amino acid catabolism" EXACT [] synonym: "sulfur amino acid degradation" EXACT [] synonym: "sulphur amino acid catabolic process" EXACT [] synonym: "sulphur amino acid catabolism" EXACT [] is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0000099 name: sulfur amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfur amino acids from one side of a membrane to the other. Sulphur amino acids contain sulfur in the form of cystine, methionine or their derivatives." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "sulfur amino acid transporter activity" BROAD [] synonym: "sulphur amino acid transmembrane transporter activity" EXACT [] synonym: "sulphur amino acid transporter activity" BROAD [] is_a: GO:0015171 ! amino acid transmembrane transporter activity relationship: part_of GO:0000101 ! sulfur amino acid transport [Term] id: GO:0000100 name: S-methylmethionine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015178 def: "Catalysis of the transfer of S-methylmethionine from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "S-methylmethionine permease activity" EXACT [] synonym: "S-methylmethionine transporter activity" BROAD [] is_a: GO:0000099 ! sulfur amino acid transmembrane transporter activity relationship: part_of GO:0015806 ! S-methylmethionine transport [Term] id: GO:0000101 name: sulfur amino acid transport namespace: biological_process def: "The directed movement of amino acids containing sulfur (cystine, methionine and their derivatives) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "sulphur amino acid transport" EXACT [] is_a: GO:0006865 ! amino acid transport [Term] id: GO:0000102 name: L-methionine secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-methionine from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "L-methionine porter activity" RELATED [] is_a: GO:0005294 ! neutral L-amino acid secondary active transmembrane transporter activity is_a: GO:0015191 ! L-methionine transmembrane transporter activity [Term] id: GO:0000103 name: sulfate assimilation namespace: biological_process alt_id: GO:0019378 def: "The pathways by which inorganic sulfate is processed and incorporated into sulfated compounds." [GOC:jl] subset: gosubset_prok synonym: "sulfate assimilation, phosphoadenylyl sulfate reduction by an oxidoreductase, acting on sulfur group of donors, NAD or NADP as acceptor" NARROW [] synonym: "sulphate assimilation" EXACT [] synonym: "sulphate assimilation, phosphoadenylyl sulphate reduction by an oxidoreductase, acting on sulphur group of donors, NAD or NADP as acceptor" NARROW [] is_a: GO:0006790 ! sulfur metabolic process [Term] id: GO:0000104 name: succinate dehydrogenase activity namespace: molecular_function alt_id: GO:0019739 def: "Catalysis of the reaction: succinate + acceptor = fumarate + reduced acceptor." [EC:1.3.99.1, GOC:kd] subset: gosubset_prok synonym: "fumarate dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "fumarate reductase activity" EXACT [EC:1.3.99.1] synonym: "fumaric hydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinate oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.1] synonym: "succinic acid dehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.99.1] synonym: "succinodehydrogenase activity" EXACT [EC:1.3.99.1] synonym: "succinyl dehydrogenase activity" EXACT [EC:1.3.99.1] xref: EC:1.3.99.1 xref: MetaCyc:SUCC-FUM-OXRED-RXN xref: Reactome:21566 "succinate dehydrogenase activity" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0000105 name: histidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine anabolism" EXACT [] synonym: "histidine biosynthesis" EXACT [] synonym: "histidine formation" EXACT [] synonym: "histidine synthesis" EXACT [] xref: MetaCyc:HISTSYN-PWY is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009076 ! histidine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0000107 name: imidazoleglycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + AICAR + L-glutamate." [MetaCyc:GLUTAMIDOTRANS-RXN] subset: gosubset_prok synonym: "glutamine amidotransferase:cyclase activity" BROAD [] synonym: "imidazole glycerol phosphate synthase activity" EXACT [] synonym: "imidazole-glycerol-phosphate synthase activity" RELATED [] synonym: "imidazoleglycerol phosphate synthase activity" EXACT [] xref: EC:2.4.2.- xref: MetaCyc:GLUTAMIDOTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000108 name: repairosome namespace: cellular_component def: "A stable complex of proteins that carry out the DNA damage recognition and incision reactions characteristic of nucleotide excision repair (NER), such as DNA damage recognition, DNA helix unwinding, and endonucleolytic cleavage at sites flanking damaged DNA; includes TFIIH subunits and additional polypeptides; may form in the absence of DNA damage." [PMID:10681587, PMID:9852079] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000109 name: nucleotide-excision repair complex namespace: cellular_component def: "Any complex formed of proteins that act in nucleotide-excision repair." [PMID:10915862] comment: Note that process information is included in the term and definition for the purpose of describing and distinguishing the complex. subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000110 name: nucleotide-excision repair factor 1 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and endodeoxynuclease activities. In S. cerevisiae, it is composed of Rad1p, Rad10p, and Rad14p; in human the subunits are ERCC4/XPF, ERCC1 and XPA, respectively." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF1 complex" EXACT [] synonym: "XPA-ERCC1-ERCC4 complex" EXACT [PMID:8197175] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000111 name: nucleotide-excision repair factor 2 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses damaged DNA binding activity. In S. cerevisiae, it is composed of Rad4p and Rad23p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF2 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000112 name: nucleotide-excision repair factor 3 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses endodeoxynuclease and DNA helicase activities. In S. cerevisiae, it is composed of Rad2p and the core TFIIH-Ssl2p complex (Core TFIIH is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. Note that Ssl2p is also called Rad25p)." [PMID:10915862, PMID:14500720, PMID:7813015] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF3 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000113 name: nucleotide-excision repair factor 4 complex namespace: cellular_component def: "One of several protein complexes involved in nucleotide-excision repair; possesses DNA damage recognition and DNA-dependent ATPase activities. In S. cerevisiae, it is composed of Rad7p and Rad16p." [PMID:10915862] comment: Note that process and function information are included in the term and definition for the purpose of describing and distinguishing the complex. synonym: "NEF4 complex" EXACT [] is_a: GO:0000109 ! nucleotide-excision repair complex [Term] id: GO:0000114 name: regulation of transcription involved in G1 phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G1 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G1-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G1 phase of cell cycle" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0000115 name: regulation of transcription involved in S-phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that regulates transcription such that the target genes are transcribed as part of the S phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "regulation of transcription from RNA polymerase II promoter during S-phase of mitotic cell cycle" RELATED [] synonym: "S-phase-specific transcription in mitotic cell cycle" RELATED [] synonym: "S-specific transcription in mitotic cell cycle" EXACT [] xref: Reactome:69241 "S-specific transcription in mitotic cell cycle" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0000116 name: regulation of transcription involved in G2-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2 phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II during G2-phase of mitotic cell cycle" RELATED [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000085 ! G2 phase of mitotic cell cycle [Term] id: GO:0000117 name: regulation of transcription involved in G2/M-phase of mitotic cell cycle namespace: biological_process def: "Any process that regulates transcription such that the target genes are transcribed as part of the G2/M phase of the mitotic cell cycle." [GOC:dph, GOC:mah, GOC:tb] synonym: "G2/M-specific transcription in mitotic cell cycle" RELATED [] synonym: "regulation of transcription from RNA polymerase II promoter during G2/M-phase of mitotic cell cycle" RELATED [] xref: Reactome:69274 "G2/M-specific transcription in mitotic cell cycle" is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0000118 name: histone deacetylase complex namespace: cellular_component def: "A protein complex that possesses histone deacetylase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone deacetylase activity ; GO:0004407'. synonym: "HDAC complex" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000120 name: RNA polymerase I transcription factor complex namespace: cellular_component def: "A transcription factor complex that acts at promoters of genes transcribed by RNA polymerase I." [GOC:mah] is_a: GO:0005667 ! transcription factor complex is_a: GO:0044452 ! nucleolar part [Term] id: GO:0000121 name: glycerol-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol 1-phosphate + H2O = glycerol + phosphate." [EC:3.1.3.21] synonym: "alpha-glycerol phosphatase activity" EXACT [EC:3.1.3.21] synonym: "alpha-glycerophosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphatase activity" EXACT [EC:3.1.3.21] synonym: "glycerol 3-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.21] synonym: "glycerol-3-phosphate phosphatase activity" EXACT [EC:3.1.3.21] xref: EC:3.1.3.21 xref: MetaCyc:GLYCEROL-1-PHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0000122 name: negative regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter" NARROW [] synonym: "negative regulation of transcription from Pol II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter relationship: negatively_regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0000123 name: histone acetyltransferase complex namespace: cellular_component def: "A protein complex that possesses histone acetyltransferase activity." [GOC:mah] comment: Note that this term represents a location, not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'histone acetyltransferase activity ; GO:0004402'. synonym: "histone acetylase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0000124 name: SAGA complex namespace: cellular_component def: "A SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof; additional polypeptides include Spt group, consisting of Spt7, Spt3, and Spt20/Ada5, which interact with the TATA-binding protein (TBP); the Ada group, consisting of Ada1, Ada2, Ada3, Ada4/Gcn5, and Ada5/Spt20, which is functionally linked to the nucleosomal HAT activity; Tra1, an ATM/PI-3 kinase-related protein that targets DNA-bound activators for recruitment to promoters; the TBP-associated factor (TAF) proteins, consisting of Taf5, Taf6, Taf9, Taf10, and Taf12, which mediate nucleosomal HAT activity and are thought to help recruit the basal transcription machinery." [PMID:10637607, PMID:17337012] synonym: "Spt-Ada-Gcn5-acetyltransferase complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000125 name: PCAF complex namespace: cellular_component def: "A large multiprotein complex that possesses histone acetyltransferase activity and is involved in regulation of transcription. The composition is similar to that of the SAGA complex, but includes fewer Spt and Ada proteins, and more TAFs." [PMID:10637607] comment: See also the cellular component term 'SAGA complex ; GO:0000124'. synonym: "PCAF histone acetylase-associated complex" EXACT [] is_a: GO:0070461 ! SAGA-type complex [Term] id: GO:0000126 name: transcription factor TFIIIB complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIB contains the TATA-binding protein (TBP) and two Pol III-specific proteins, B'' and BRF." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000127 name: transcription factor TFIIIC complex namespace: cellular_component def: "A transcription factor complex that is involved in regulating transcription from RNA polymerase III (Pol III) promoters. TFIIIC contains three conserved subunits that associate with the proximal Pol III promoter element, and additional subunits that associate with sequence elements downstream of the promoter and are more diverged among species." [GOC:mah, PMID:11433012] is_a: GO:0005667 ! transcription factor complex [Term] id: GO:0000128 name: flocculation namespace: biological_process def: "The non-sexual aggregation of single-celled organisms." [GOC:jl] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Flocculation is_a: GO:0051704 ! multi-organism process [Term] id: GO:0000131 name: incipient cellular bud site namespace: cellular_component def: "The portion of the budding yeast plasma membrane where a daughter cell will emerge. The yeast marks this spot with bud-site selection proteins before bud emergence occurs. Actin is polarized to this spot just prior to and during bud emergence." [GOC:clt] is_a: GO:0044424 ! intracellular part [Term] id: GO:0000132 name: establishment of mitotic spindle orientation namespace: biological_process alt_id: GO:0030607 alt_id: GO:0030609 def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures." [GOC:ems] synonym: "establishment of spindle orientation during mitosis" RELATED [GOC:dph, GOC:tb] synonym: "establishment of spindle orientation involved in mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "mitotic spindle orientation" EXACT [] synonym: "orienting of mitotic spindle" EXACT [] is_a: GO:0040001 ! establishment of mitotic spindle localization is_a: GO:0051294 ! establishment of spindle orientation [Term] id: GO:0000133 name: polarisome namespace: cellular_component def: "Protein complex that plays a role in determining cell polarity by directing the localized assembly of actin filaments at polarization sites; in Saccharomyces the polarisome includes Bni1p, Spa2p, Pea2p, and Bud6p." [PMID:14734532, PMID:14998522, PMID:9632790] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030427 ! site of polarized growth [Term] id: GO:0000135 name: septin checkpoint namespace: biological_process def: "A cell cycle checkpoint that detects septin defects and responds by inhibiting the mitotic CDK. In Saccharomyces cerevisiae, correct formation of a functional septin cytoskeleton permits the cell to switch to isotropic bud growth and the onset of mitotic chromosome segregation. In the presence of septin defects, the mitotic CDK is inhibited and both the switch to isotropic bud growth and the onset of mitotic chromosome segregation is delayed." [PMID:9925642] is_a: GO:0031565 ! cytokinesis checkpoint [Term] id: GO:0000136 name: alpha-1,6-mannosyltransferase complex namespace: cellular_component def: "A large, multiprotein complex with alpha-1,6 mannosyltransferase activity, located in the cis Golgi membrane; adds mannan to N-linked glycans on proteins." [GOC:mcc, PMID:10037752, PMID:11095735] is_a: GO:0031501 ! mannosyltransferase complex is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0000137 ! Golgi cis cisterna [Term] id: GO:0000137 name: Golgi cis cisterna namespace: cellular_component def: "The Golgi cisterna closest to the endoplasmic reticulum; the first processing compartment through which proteins pass after export from the ER." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000138 name: Golgi trans cisterna namespace: cellular_component def: "The Golgi cisterna farthest from the endoplasmic reticulum; the final processing compartment through which proteins pass before exiting the Golgi apparatus; the compartment in which N-linked protein glycosylation is completed." [ISBN:0815316194] synonym: "late Golgi" RELATED [GOC:mah] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0000139 name: Golgi membrane namespace: cellular_component def: "The lipid bilayer surrounding any of the compartments of the Golgi apparatus." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044431 ! Golgi apparatus part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0000140 name: acylglycerone-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-palmitoylglycerol 3-phosphate + NADP+ = palmitoylglycerone phosphate + NADPH + H+." [EC:1.1.1.101] synonym: "1-acyldihydroxyacetone-phosphate reductase activity" EXACT [] synonym: "1-palmitoylglycerol-3-phosphate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.101] synonym: "acyldihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl dihydroxyacetone phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyl-dihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] synonym: "palmitoyldihydroxyacetone-phosphate reductase activity" EXACT [EC:1.1.1.101] xref: EC:1.1.1.101 xref: MetaCyc:ACYLGLYCERONE-PHOSPHATE-REDUCTASE-RXN xref: Reactome:21659 "acylglycerone-phosphate reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000142 name: cellular bud neck contractile ring namespace: cellular_component def: "A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane at the mother-bud neck in mitotic cells that divide by budding in preparation for completing cytokinesis. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, PMID:16009555] synonym: "neck ring" EXACT [] is_a: GO:0005826 ! actomyosin contractile ring intersection_of: GO:0005826 ! actomyosin contractile ring intersection_of: part_of GO:0005935 ! cellular bud neck relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000144 name: cellular bud neck septin ring namespace: cellular_component def: "A ring-shaped structure that forms at the site of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins. In S. cerevisiae, this structure forms at the time of bud emergence and the septins show a high rate of exchange." [GOC:krc, PMID:16009555] is_a: GO:0000399 ! cellular bud neck septin structure is_a: GO:0005940 ! septin ring is_a: GO:0032161 ! cleavage apparatus septin structure intersection_of: GO:0005940 ! septin ring intersection_of: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000145 name: exocyst namespace: cellular_component def: "A protein complex peripherally associated with the plasma membrane that determines where vesicles dock and fuse. At least eight complex components are conserved between yeast and mammals." [PMID:9700152] synonym: "Sec6/8 complex" EXACT [] xref: Wikipedia:Exocyst is_a: GO:0043234 ! protein complex is_a: GO:0044448 ! cell cortex part [Term] id: GO:0000146 name: microfilament motor activity namespace: molecular_function def: "Catalysis of movement along a microfilament, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] synonym: "actin filament motor activity" EXACT [GOC:dph] synonym: "actin-filament motor activity" EXACT [] synonym: "muscle motor activity" NARROW [] synonym: "myosin ATPase activity" RELATED [] xref: Reactome:10657 "microfilament motor activity" is_a: GO:0003774 ! motor activity [Term] id: GO:0000147 name: actin cortical patch assembly namespace: biological_process def: "Assembly of an actin cortical patch, a discrete actin-containing structure found at the plasma membrane of fungal cells." [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0030866 ! cortical actin cytoskeleton organization [Term] id: GO:0000148 name: 1,3-beta-glucan synthase complex namespace: cellular_component def: "A protein complex that catalyzes the transfer of a glucose moiety from UDP-glucose to a 1,3-beta-D-glucan chain." [EC:2.4.1.34] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0000149 name: SNARE binding namespace: molecular_function def: "Interacting selectively and non-covalently with a SNARE (soluble N-ethylmaleimide-sensitive factor attached protein receptor) protein." [PMID:12642621] synonym: "SNAP receptor binding" EXACT [] xref: Reactome:15373 "SNARE binding" is_a: GO:0005515 ! protein binding [Term] id: GO:0000150 name: recombinase activity namespace: molecular_function def: "Catalysis of the identification and base-pairing of homologous sequences between single-stranded DNA and double-stranded DNA." [GOC:elh] comment: Note that this term represents activities that do not break or form phosphodiester bonds, and is therefore not a parent of 'site-specific recombinase activity ; GO:0009009'. subset: gosubset_prok synonym: "strand transferase" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0000151 name: ubiquitin ligase complex namespace: cellular_component def: "A protein complex that includes a ubiquitin-protein ligase and other proteins that may confer substrate specificity on the complex." [PMID:9529603] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000152 name: nuclear ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the nucleus." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044428 ! nuclear part intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000153 name: cytoplasmic ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the cytoplasm." [GOC:mah] is_a: GO:0000151 ! ubiquitin ligase complex is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000154 name: rRNA modification namespace: biological_process alt_id: GO:0016548 def: "The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "rRNA editing" NARROW [GOC:hjd] is_a: GO:0006364 ! rRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0000155 name: two-component sensor activity namespace: molecular_function def: "Catalysis of the phosphorylation of a specific transcription regulator in response to the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok synonym: "two-component sensor molecule" NARROW [] synonym: "two-component system sensor activity " EXACT [] xref: EC:2.7.3.- is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0000156 name: two-component response regulator activity namespace: molecular_function def: "Alters the level of transcription of target genes, usually by binding to a transcription factor, when phosphorylated by a sensor that detects the presence of a particular signal substance outside the cell." [GOC:mah] subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity is_a: GO:0030528 ! transcription regulator activity relationship: part_of GO:0070297 ! regulation of two-component signal transduction system (phosphorelay) [Term] id: GO:0000159 name: protein phosphatase type 2A complex namespace: cellular_component def: "A protein complex that has protein serine/threonine phosphatase activity that is polycation-stimulated (PCS), being directly stimulated by protamine, polylysine, or histone H1; it constitutes a subclass of several enzymes activated by different histones and polylysine, and consists of catalytic, scaffolding, and regulatory subunits. The catalytic and scaffolding subunits form the core enzyme, and the holoenzyme also includes the regulatory subunit." [GOC:mah, ISBN:0198547684, PMID:17245430] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000160 name: two-component signal transduction system (phosphorelay) namespace: biological_process def: "A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins." [PMID:9191038] subset: gosubset_prok synonym: "histidyl-aspartyl phosphorelay" EXACT [] is_a: GO:0023060 ! signal transmission [Term] id: GO:0000161 name: MAPKKK cascade involved in osmosensory signaling pathway namespace: biological_process def: "MAPKKK cascade involved in signal transduction in response to change in osmotic conditions." [PMID:9561267] synonym: "MAPKKK cascade during osmolarity sensing" EXACT [] synonym: "osmolarity sensing, MAPKKK cascade" EXACT [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0000162 name: tryptophan biosynthetic process namespace: biological_process alt_id: GO:0009096 def: "The chemical reactions and pathways resulting in the formation of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid; tryptophan is synthesized from chorismate via anthranilate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways", MetaCyc:TRPSYN-PWY] subset: gosubset_prok synonym: "aromatic amino acid family biosynthetic process, anthranilate pathway" EXACT [] synonym: "tryptophan anabolism" EXACT [] synonym: "tryptophan biosynthesis" EXACT [] synonym: "tryptophan formation" EXACT [] synonym: "tryptophan synthesis" EXACT [] xref: MetaCyc:TRPSYN-PWY is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009073 ! aromatic amino acid family biosynthetic process is_a: GO:0046219 ! indolalkylamine biosynthetic process [Term] id: GO:0000164 name: protein phosphatase type 1 complex namespace: cellular_component def: "A protein complex that possesses magnesium-dependent protein serine/threonine phosphatase (AMD phosphatase) activity, and consists of a catalytic subunit and one or more regulatory subunits that dictates the phosphatase's substrate specificity, function, and activity." [GOC:mah, GOC:ssd] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000165 name: MAPKKK cascade namespace: biological_process def: "A cascade of at least three protein kinase activities culminating in the phosphorylation and activation of a MAP kinase. MAPKKK cascades lie downstream of numerous signaling pathways." [GOC:mah, PMID:9561267] synonym: "ERK/MAPK cascade" EXACT [] synonym: "MAP kinase cascade" EXACT [] synonym: "MAP kinase kinase kinase cascade" EXACT [] synonym: "MAPK cascade" EXACT [] synonym: "MAPK signaling" RELATED [] synonym: "MAPK signalling" RELATED [] synonym: "MAPKKK cascade during sporulation" NARROW [] xref: Reactome:109869 "MAP kinase cascade" xref: Reactome:562693 "MAP kinase cascade" xref: Reactome:588314 "MAP kinase cascade" xref: Reactome:609058 "MAP kinase cascade" xref: Reactome:633751 "MAP kinase cascade" xref: Reactome:645360 "MAP kinase cascade" xref: Reactome:655728 "MAP kinase cascade" xref: Reactome:661175 "MAP kinase cascade" xref: Reactome:666953 "MAP kinase cascade" xref: Reactome:673088 "MAP kinase cascade" xref: Reactome:678788 "MAP kinase cascade" xref: Reactome:683716 "MAP kinase cascade" xref: Reactome:689933 "MAP kinase cascade" xref: Reactome:701708 "MAP kinase cascade" xref: Reactome:716285 "MAP kinase cascade" xref: Reactome:728228 "MAP kinase cascade" xref: Reactome:731060 "MAP kinase cascade" xref: Wikipedia:MAPK_cascade xref: Wikipedia:Mitogen-activated_protein_kinase is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0000166 name: nucleotide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose moiety." [GOC:mah, ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0000167 name: activation of MAPKKK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKKK activity during osmolarity sensing" EXACT [] synonym: "osmolarity sensing, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000168 name: activation of MAPKK activity involved in osmosensory signaling pathway namespace: biological_process alt_id: GO:0007233 def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase during osmolarity sensing." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during osmolarity sensing" EXACT [] synonym: "activation of MAPKK activity during osmolarity sensing" EXACT [] synonym: "activation of Pbs2 kinase" NARROW [] synonym: "osmolarity sensing, activation of MAP kinase kinase activity" EXACT [] synonym: "osmolarity sensing, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000169 name: activation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase activity during osmolarity sensing." [PMID:9561267] synonym: "activation of MAPK activity during osmolarity sensing" EXACT [] synonym: "osmolarity sensing, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000170 name: sphingosine hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of sphingolipid long chain bases." [PMID:9556590] xref: Reactome:21747 "sphingosine hydroxylase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0000171 name: ribonuclease MRP activity namespace: molecular_function def: "Catalysis of the site-specific cleavage of RNA by a catalytic RNA_mediated mechanism; substrates include the A3 site in the ITS1 of pre-rRNA." [PMID:17881380] synonym: "RNase MRP" EXACT [] xref: Wikipedia:RNase_MRP is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0000172 name: ribonuclease MRP complex namespace: cellular_component def: "A ribonucleoprotein complex that contains an RNA molecule of the snoRNA family, and cleaves the rRNA precursor as part of rRNA transcript processing. It also has other roles: In S. cerevisiae it is involved in cell cycle-regulated degradation of daughter cell-specific mRNAs, while in mammalian cells it also enters the mitochondria and processes RNAs to create RNA primers for DNA replication." [GOC:sgd_curators, PMID:10690410, PMID:14729943, PMID:7510714] synonym: "ribonuclease mitochondrial RNA processing complex" EXACT [] synonym: "RNase MRP complex" EXACT [] is_a: GO:0005732 ! small nucleolar ribonucleoprotein complex [Term] id: GO:0000173 name: inactivation of MAPK activity involved in osmosensory signaling pathway namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase during osmolarity sensing." [PMID:9561267] synonym: "inactivation of MAPK activity during osmolarity sensing" EXACT [] synonym: "osmolarity sensing, inactivation of MAPK" EXACT [] synonym: "osmolarity sensing, termination of MAPK activity" EXACT [] synonym: "termination of MAPK activity during osmolarity sensing" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000174 name: inactivation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0000175 name: 3'-5'-exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "3'-5' exoribonuclease activity" EXACT [] xref: EC:3.1.13.- xref: Reactome:21755 "3'-5'-exoribonuclease activity" is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0000176 name: nuclear exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the nucleus." [PMID:10465791] synonym: "eukaryotic exosome multienzyme ribonuclease complex" EXACT [] synonym: "nuclear exosome (ribonuclease complex)" EXACT [] synonym: "nuclear exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044428 ! nuclear part intersection_of: GO:0000178 ! exosome (RNase complex) intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000177 name: cytoplasmic exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases found in the cytoplasm." [PMID:10465791] synonym: "cytoplasmic exosome (ribonuclease complex)" EXACT [] synonym: "cytoplasmic exosome multienzyme ribonuclease complex" EXACT [] synonym: "prokaryotic exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0000178 ! exosome (RNase complex) is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000178 ! exosome (RNase complex) intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000178 name: exosome (RNase complex) namespace: cellular_component def: "Complex of 3'-5' exoribonucleases." [PMID:10465791] comment: Note that this term should not be confused with 'exosome' used in the context of vesicles released from multivesicular bodies. subset: goslim_pir synonym: "exosome (ribonucleasease complex)" EXACT [] synonym: "exosome multienzyme ribonuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000179 name: rRNA (adenine-N6,N6-)-dimethyltransferase activity namespace: molecular_function alt_id: GO:0043790 def: "Catalysis of the dimethylation two adjacent A residues in the loop closing the 3'-terminal stem of the 18S rRNA, using S-adenosyl-L-methionine as a methyl donor." [ISBN:1555811337 "Modification and Editing of RNA", PMID:10690410] subset: gosubset_prok synonym: "18S rRNA dimethylase activity" EXACT [] synonym: "dimethyladenosine transferase activity" EXACT [IMG:02532] synonym: "S-adenosylmethionine-6-N', N'-adenosyl(rRNA) dimethyltransferase activity" EXACT [IMG:02532] xref: EC:2.1.1.- is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0000180 name: cytosolic large ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022625 [Term] id: GO:0000181 name: cytosolic small ribosomal subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0022627 [Term] id: GO:0000182 name: rDNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA sequences encoding ribosomal RNA." [GOC:mah] synonym: "ribosomal DNA binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0000183 name: chromatin silencing at rDNA namespace: biological_process def: "Repression of transcription of ribosomal DNA by altering the structure of chromatin." [PMID:10219245] synonym: "chromatin silencing at ribosomal DNA" EXACT [] synonym: "heterochromatic silencing at rDNA" EXACT [] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0000184 name: nuclear-transcribed mRNA catabolic process, nonsense-mediated decay namespace: biological_process def: "The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins." [GOC:krc, GOC:ma, PMID:10025395] synonym: "mRNA breakdown, nonsense-mediated decay" EXACT [] synonym: "mRNA catabolic process, nonsense-mediated" EXACT [] synonym: "mRNA catabolism, nonsense-mediated" EXACT [] synonym: "mRNA degradation, nonsense-mediated decay" EXACT [] synonym: "nonsense-mediated mRNA decay" EXACT [] synonym: "nuclear mRNA catabolic process, nonsense-mediated decay" EXACT [] xref: Wikipedia:Nonsense-mediated_decay xref: Wikipedia:Nonsense-mediated_mRNA_decay is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000185 name: activation of MAPKKK activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase" EXACT [] synonym: "activation of MAPKKK activity during sporulation" NARROW [] synonym: "positive regulation of MAP kinase kinase kinase activity" BROAD [] synonym: "positive regulation of MAPKKK activity" BROAD [] is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000186 name: activation of MAPKK activity namespace: biological_process alt_id: GO:0007255 def: "The initiation of the activity of the inactive enzyme MAP kinase kinase by phosphorylation by a MAPKKK." [PMID:9561267] synonym: "activation of MAP kinase kinase activity" EXACT [] synonym: "activation of MAP/ERK kinase kinase" EXACT [] synonym: "activation of MAPKK activity during sporulation" NARROW [] synonym: "positive regulation of MAPKK activity" BROAD [] xref: Reactome:110049 "MEK activation" xref: Reactome:169893 "Prolonged ERK activation events" xref: Reactome:562528 "Prolonged ERK activation events" xref: Reactome:562692 "MEK activation" xref: Reactome:588154 "Prolonged ERK activation events" xref: Reactome:588313 "MEK activation" xref: Reactome:608922 "Prolonged ERK activation events" xref: Reactome:609057 "MEK activation" xref: Reactome:633604 "Prolonged ERK activation events" xref: Reactome:633750 "MEK activation" xref: Reactome:645245 "Prolonged ERK activation events" xref: Reactome:645359 "MEK activation" xref: Reactome:655621 "Prolonged ERK activation events" xref: Reactome:655727 "MEK activation" xref: Reactome:661182 "Prolonged ERK activation events" xref: Reactome:666960 "Prolonged ERK activation events" xref: Reactome:673095 "Prolonged ERK activation events" xref: Reactome:678795 "Prolonged ERK activation events" xref: Reactome:683723 "Prolonged ERK activation events" xref: Reactome:689940 "Prolonged ERK activation events" xref: Reactome:701715 "Prolonged ERK activation events" xref: Reactome:716292 "Prolonged ERK activation events" xref: Reactome:728235 "Prolonged ERK activation events" xref: Reactome:731071 "Prolonged ERK activation events" is_a: GO:0006468 ! protein amino acid phosphorylation is_a: GO:0032147 ! activation of protein kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000187 name: activation of MAPK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme MAP kinase by phosphorylation by a MAPKK." [PMID:9561267] synonym: "activation of MAP kinase" EXACT [] synonym: "activation of MAPK activity during sporulation" NARROW [] synonym: "MAPK activation" EXACT [] xref: Reactome:112409 "ERK activation" xref: Reactome:450302 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:562685 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:563117 "ERK activation" xref: Reactome:588310 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:588729 "ERK activation" xref: Reactome:609050 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:609465 "ERK activation" xref: Reactome:633743 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:634166 "ERK activation" xref: Reactome:645356 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:645675 "ERK activation" xref: Reactome:655726 "activated TAK1 mediates p38 MAPK activation" xref: Reactome:656005 "ERK activation" xref: Reactome:661174 "ERK activation" xref: Reactome:666952 "ERK activation" xref: Reactome:673087 "ERK activation" xref: Reactome:678787 "ERK activation" xref: Reactome:683715 "ERK activation" xref: Reactome:689932 "ERK activation" xref: Reactome:701707 "ERK activation" xref: Reactome:716284 "ERK activation" xref: Reactome:728227 "ERK activation" xref: Reactome:731059 "ERK activation" is_a: GO:0006468 ! protein amino acid phosphorylation is_a: GO:0043406 ! positive regulation of MAP kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000188 name: inactivation of MAPK activity namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase." [PMID:9561267] synonym: "inactivation of MAPK during sporulation" NARROW [] synonym: "termination of MAPK activity" EXACT [] is_a: GO:0043407 ! negative regulation of MAP kinase activity relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000189 name: nuclear translocation of MAPK namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus upon activation." [PMID:9561267] xref: Reactome:109867 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:109868 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:112353 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:556252 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:556253 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:604756 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:604757 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:628892 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:628893 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:642893 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:642894 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:653436 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:653437 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:659822 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:659824 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:665541 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:665543 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:671573 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:671575 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:677442 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:677444 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:682504 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:682506 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:688450 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:688452 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:699339 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:699341 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:713488 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:713490 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:726480 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:726482 "Nuclear translocation of phospho-ERK-2 dimer" xref: Reactome:730355 "Nuclear translocation of phospho-ERK-1 dimer" xref: Reactome:730357 "Nuclear translocation of phospho-ERK-2 dimer" is_a: GO:0000060 ! protein import into nucleus, translocation relationship: part_of GO:0000165 ! MAPKKK cascade [Term] id: GO:0000190 name: MAPKKK cascade (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000191 name: activation of MAPKKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000192 name: activation of MAPKK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000193 name: activation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000194 name: inactivation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000195 name: nuclear translocation of MAPK (pseudohyphal growth) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of regulating pseudohyphal or invasive growth." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000196 name: MAPKKK cascade involved in cell wall biogenesis namespace: biological_process def: "A MAPKKK cascade culminating in the phosphorylation and activation of a MAP kinase that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, MAPKKK cascade" EXACT [] is_a: GO:0000165 ! MAPKKK cascade relationship: part_of GO:0042546 ! cell wall biogenesis [Term] id: GO:0000197 name: activation of MAPKKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKKK activity" EXACT [] is_a: GO:0000185 ! activation of MAPKKK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000198 name: activation of MAPKK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAP kinase kinase activity during cell wall biogenesis" EXACT [] synonym: "activation of MAPKK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAP kinase kinase activity" EXACT [] synonym: "cell wall biogenesis, activation of MAPKK activity" EXACT [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000199 name: activation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "activation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "cell wall biogenesis, activation of MAPK activity" EXACT [] is_a: GO:0000187 ! activation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000200 name: inactivation of MAPK activity involved in cell wall biogenesis namespace: biological_process def: "Any process that terminates the activity of the active enzyme MAP kinase in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, inactivation of MAPK activity" EXACT [] synonym: "cell wall biogenesis, termination of MAPK activity" EXACT [] synonym: "inactivation of MAPK activity involved in cell wall integrity" EXACT [GOC:dgf] synonym: "termination of MAPK activity during cell wall biogenesis" EXACT [] is_a: GO:0000188 ! inactivation of MAPK activity relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000201 name: nuclear translocation of MAPK involved in cell wall biogenesis namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus that occurs in the context of cell wall biogenesis, the assembly and arrangement of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells." [PMID:9561267] synonym: "cell wall biogenesis, nuclear translocation of MAPK" EXACT [] synonym: "nuclear translocation of MAPK involved in cell wall integrity" EXACT [GOC:dgf] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000196 ! MAPKKK cascade involved in cell wall biogenesis [Term] id: GO:0000202 name: MAPKKK cascade during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of signal promoting sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000203 name: activation of MAPKKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000204 name: activation of MAPKK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000205 name: activation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000206 name: inactivation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Downregulation of MAP kinase activity in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000207 name: nuclear translocation of MAPK during sporulation (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of sporulation. As in, but not restricted to, the taxon Saccharomyces (Saccharomyces, ncbi_taxonomy_id:4930)." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true [Term] id: GO:0000208 name: nuclear translocation of MAPK involved in osmosensory signaling pathway namespace: biological_process def: "The directed movement of a MAP kinase to the nucleus during osmolarity sensing." [PMID:9561267] synonym: "nuclear translocation of MAPK during osmolarity sensing" EXACT [] synonym: "osmolarity sensing, nuclear translocation of MAPK" EXACT [] is_a: GO:0000189 ! nuclear translocation of MAPK relationship: part_of GO:0000161 ! MAPKKK cascade involved in osmosensory signaling pathway [Term] id: GO:0000209 name: protein polyubiquitination namespace: biological_process def: "Addition of multiple ubiquitin moieties to a protein, forming a ubiquitin chain." [ISBN:0815316194] synonym: "polyubiquitin" RELATED [] synonym: "protein polyubiquitinylation" EXACT [] synonym: "protein polyubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0000210 name: NAD+ diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = AMP + NMN." [EC:3.6.1.22] subset: gosubset_prok synonym: "NAD diphosphatase activity" EXACT [] synonym: "NAD pyrophosphatase activity" EXACT [] synonym: "NAD(+) pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ phosphohydrolase activity" EXACT [EC:3.6.1.22] synonym: "NAD+ pyrophosphatase activity" EXACT [EC:3.6.1.22] synonym: "NADH pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "NADP pyrophosphatase activity" BROAD [EC:3.6.1.22] synonym: "nicotinamide adenine dinucleotide pyrophosphatase activity" EXACT [EC:3.6.1.22] xref: EC:3.6.1.22 xref: MetaCyc:NADPYROPHOSPHAT-RXN is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0000211 name: protein degradation tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of polyubiquitin to another protein, targeting the tagged protein for destruction." [GOC:cl, ISBN:0815316194] comment: This term was made obsolete because it represents a biological process and a molecular function. is_obsolete: true consider: GO:0005515 consider: GO:0019941 consider: GO:0042787 [Term] id: GO:0000212 name: meiotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a meiotic cell cycle." [GOC:mah] synonym: "meiotic spindle organisation" EXACT [GOC:curators] synonym: "meiotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization during meiosis" EXACT [GOC:mah] is_a: GO:0007051 ! spindle organization is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000213 name: tRNA-intron endonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] synonym: "splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer ribonucleate intron endoribonuclease activity" EXACT [EC:3.1.27.9] synonym: "transfer splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNA-intron endoribonuclease activity" EXACT [] synonym: "tRNA-splicing endonuclease activity" EXACT [EC:3.1.27.9] synonym: "tRNATRPintron endonuclease activity" EXACT [EC:3.1.27.9] xref: EC:3.1.27.9 xref: MetaCyc:3.1.27.9-RXN is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0000214 name: tRNA-intron endonuclease complex namespace: cellular_component def: "A protein complex that catalyzes the endonucleolytic cleavage of pre-tRNA, producing 5'-hydroxyl and 2',3'-cyclic phosphate termini, and specifically removing the intron." [EC:3.1.27.9] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000215 name: tRNA 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-phospho-[ligated tRNA] + NAD+ = mature tRNA + ADP ribose 1'',2''-phosphate + nicotinamide + H2O; transfers the splice junction 2-phosphate from ligated tRNA to NAD+ to produce ADP-ribose 1'-2' cyclic phosphate." [EC:2.7.1.160, PMID:9148937] synonym: "2'-phospho-[ligated tRNA]:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "2'-phospho-tRNA:NAD+ phosphotransferase activity" EXACT [EC:2.7.1.160] synonym: "Tpt1" RELATED [EC:2.7.1.160] synonym: "Tpt1p" RELATED [EC:2.7.1.160] synonym: "yeast 2'-phosphotransferase activity" NARROW [EC:2.7.1.160] xref: EC:2.7.1.160 xref: MetaCyc:2.7.1.160-RXN is_a: GO:0008665 ! 2'-phosphotransferase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0000216 name: M/G1 transition of mitotic cell cycle namespace: biological_process def: "Progression from M phase to G1 phase of the mitotic cell cycle." [GOC:mah] xref: Reactome:562918 "M/G1 Transition" xref: Reactome:588539 "M/G1 Transition" xref: Reactome:609281 "M/G1 Transition" xref: Reactome:633974 "M/G1 Transition" xref: Reactome:645537 "M/G1 Transition" xref: Reactome:655929 "M/G1 Transition" xref: Reactome:661284 "M/G1 Transition" xref: Reactome:666908 "M/G1 Transition" xref: Reactome:673030 "M/G1 Transition" xref: Reactome:678750 "M/G1 Transition" xref: Reactome:683833 "M/G1 Transition" xref: Reactome:68874 "M/G1 Transition" xref: Reactome:701578 "M/G1 Transition" xref: Reactome:716162 "M/G1 Transition" xref: Reactome:728111 "M/G1 Transition" xref: Reactome:733075 "M/G1 Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051329 ! interphase of mitotic cell cycle [Term] id: GO:0000217 name: DNA secondary structure binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing secondary structure elements such as four-way junctions, bubbles, loops, Y-form DNA, or double-strand/single-strand junctions." [GOC:krc] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0000219 name: vacuolar hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" EXACT [] is_obsolete: true consider: GO:0016469 [Term] id: GO:0000220 name: vacuolar proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain often consists of five subunits, although in some mammalian tissues it may have an additional subunit. synonym: "vacuolar hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044437 ! vacuolar part intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000221 name: vacuolar proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the vacuolar membrane." [GOC:mah, PMID:16449553] comment: Note that this domain generally consists of eight subunits. synonym: "vacuolar hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044437 ! vacuolar part intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: part_of GO:0005773 ! vacuole relationship: part_of GO:0016471 ! vacuolar proton-transporting V-type ATPase complex [Term] id: GO:0000222 name: plasma membrane proton-transporting V-type ATPase, V0 domain namespace: cellular_component def: "The V0 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V0 domain" EXACT [] is_a: GO:0033179 ! proton-transporting V-type ATPase, V0 domain is_a: GO:0044459 ! plasma membrane part intersection_of: GO:0033179 ! proton-transporting V-type ATPase, V0 domain intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000223 name: plasma membrane proton-transporting V-type ATPase, V1 domain namespace: cellular_component def: "The V1 domain of a proton-transporting V-type ATPase found in the plasma membrane." [GOC:mah] synonym: "plasma membrane hydrogen ion-transporting ATPase V1 domain" EXACT [] is_a: GO:0033180 ! proton-transporting V-type ATPase, V1 domain is_a: GO:0044459 ! plasma membrane part intersection_of: GO:0033180 ! proton-transporting V-type ATPase, V1 domain intersection_of: part_of GO:0005886 ! plasma membrane relationship: part_of GO:0005887 ! integral to plasma membrane relationship: part_of GO:0033181 ! plasma membrane proton-transporting V-type ATPase complex [Term] id: GO:0000224 name: peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of an N4-(acetyl-beta-D-glucosaminyl)asparagine residue in which the N-acetyl-D-glucosamine residue may be further glycosylated, to yield a (substituted) N-acetyl-beta-D-glucosaminylamine and the peptide containing an aspartic residue." [EC:3.5.1.52] subset: gosubset_prok synonym: "glycopeptidase activity" BROAD [EC:3.5.1.52] synonym: "glycopeptide N-glycosidase activity" BROAD [EC:3.5.1.52] synonym: "jack-bean glycopeptidase" NARROW [EC:3.5.1.52] synonym: "N-glycanase activity" RELATED [EC:3.5.1.52] synonym: "N-linked-glycopeptide-(N-acetyl-beta-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.52] synonym: "N-oligosaccharide glycopeptidase activity" RELATED [EC:3.5.1.52] synonym: "peptide:N-glycanase" RELATED [] synonym: "PNGase" EXACT [] synonym: "PNGase A" RELATED [EC:3.5.1.52] synonym: "PNGase F" RELATED [EC:3.5.1.52] xref: EC:3.5.1.52 xref: MetaCyc:3.5.1.52-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0000225 name: N-acetylglucosaminylphosphatidylinositol deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosaminylphosphatidylinositol + H2O = D-glucosaminylphosphatidylinositol + acetate. The second step enzyme catalyzing the biosynthesis of glycosylphosphatidylinositol (GPI), used to anchor various eukaryotic proteins to the cell-surface membrane. Catalyzes the N-deacetylation of GlcNAc-PI to GlcN-PI." [EC:3.5.1.89] comment: Note that this function was formerly EC:3.1.1.69. synonym: "6-(N-acetyl-alpha-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "acetylglucosaminylphosphatidylinositol deacetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI de-N-acetylase activity" EXACT [EC:3.5.1.89] synonym: "GlcNAc-PI deacetylase activity" EXACT [EC:3.5.1.89] synonym: "N-acetyl-D-glucosaminylphosphatidylinositol acetylhydrolase activity" EXACT [EC:3.5.1.89] synonym: "N-acetylglucosaminylphosphatidylinositol de-N-acetylase activity" EXACT [EC:3.5.1.89] xref: EC:3.5.1.89 xref: MetaCyc:3.1.1.69-RXN xref: Reactome:22619 "N-acetylglucosaminylphosphatidylinositol deacetylase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0000226 name: microtubule cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins." [GOC:mah] synonym: "microtubule cytoskeleton organization and biogenesis" RELATED [GOC:mah] synonym: "microtubule dynamics" EXACT [GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0000227 name: oxaloacetate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of oxaloacetate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "oxaloacetate carrier activity" RELATED [] is_a: GO:0015131 ! oxaloacetate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0000228 name: nuclear chromosome namespace: cellular_component def: "A chromosome found in the nucleus of a eukaryotic cell." [GOC:mah] subset: goslim_generic synonym: "nuclear interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044428 ! nuclear part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000229 name: cytoplasmic chromosome namespace: cellular_component def: "A chromosome found in the cytoplasm." [GOC:mah] subset: goslim_generic subset: gosubset_prok synonym: "cytoplasmic interphase chromosome" NARROW [] is_a: GO:0005694 ! chromosome is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000230 name: nuclear mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000794 [Term] id: GO:0000231 name: cytoplasmic mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during mitosis." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000793 [Term] id: GO:0000232 name: nuclear interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the nucleus during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000228 [Term] id: GO:0000233 name: cytoplasmic interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cytoplasm during interphase." [GOC:mah] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000229 [Term] id: GO:0000234 name: phosphoethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + ethanolamine phosphate = S-adenosyl-L-homocysteine + N-methylethanolamine phosphate." [EC:2.1.1.103] synonym: "phosphoethanolamine methyltransferase activity" EXACT [EC:2.1.1.103] synonym: "S-adenosyl-L-methionine:ethanolamine-phosphate N-methyltransferase activity" EXACT [EC:2.1.1.103] xref: EC:2.1.1.103 xref: MetaCyc:2.1.1.103-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000235 name: astral microtubule namespace: cellular_component def: "Any of the spindle microtubules that radiate in all directions from the spindle poles and are thought to contribute to the forces that separate the poles and position them in relation to the rest of the cell." [ISBN:0815316194] is_a: GO:0005876 ! spindle microtubule is_a: GO:0005881 ! cytoplasmic microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0005818 ! aster relationship: part_of GO:0005818 ! aster [Term] id: GO:0000236 name: mitotic prometaphase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prometaphase, the stage following prophase in mitosis (in higher eukaryotes) during which the nuclear envelope is disrupted and breaks into membrane vesicles, and the spindle microtubules enter the nuclear region. Kinetochores mature on each centromere and attach to some of the spindle microtubules. Kinetochore microtubules begin the process of aligning chromosomes in one plane halfway between the poles." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Reactome:563263 "Mitotic Prometaphase" xref: Reactome:588872 "Mitotic Prometaphase" xref: Reactome:609587 "Mitotic Prometaphase" xref: Reactome:634296 "Mitotic Prometaphase" xref: Reactome:645841 "Mitotic Prometaphase" xref: Reactome:656161 "Mitotic Prometaphase" xref: Reactome:661303 "Mitotic Prometaphase" xref: Reactome:667081 "Mitotic Prometaphase" xref: Reactome:673230 "Mitotic Prometaphase" xref: Reactome:678914 "Mitotic Prometaphase" xref: Reactome:683843 "Mitotic Prometaphase" xref: Reactome:68877 "Mitotic Prometaphase" xref: Reactome:690096 "Mitotic Prometaphase" xref: Reactome:720918 "Mitotic Prometaphase" xref: Reactome:728368 "Mitotic Prometaphase" is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0000237 name: leptotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the first stage of prophase I in meiosis, in which chromosomes first become visible." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Leptotene xref: Wikipedia:Meiosis#Leptotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000238 name: zygotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the second stage of prophase I in meiosis, in which each chromosome pairs with its homolog; the two become aligned and crossing over may occur." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Zygotene xref: Wikipedia:Zygotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000239 name: pachytene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the third stage of prophase I in meiosis, in which crossing over occurs between a chromatid in one partner and another chromatid in the homologous chromosome." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Pachytene xref: Wikipedia:Pachytene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000240 name: diplotene namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the fourth stage of prophase I in meiosis, in which the homologous chromosomes begin to separate and the synaptonemal complex dissolves." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Diplotene xref: Wikipedia:Meiosis#Diplotene is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000241 name: diakinesis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Diakinesis xref: Wikipedia:Meiosis#Diakinesis is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007128 ! meiotic prophase I [Term] id: GO:0000242 name: pericentriolar material namespace: cellular_component def: "A network of small fibers that surrounds the centrioles in cells; contains the microtubule nucleating activity of the centrosome." [GOC:clt, ISBN:0815316194] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0000243 name: commitment complex namespace: cellular_component def: "A spliceosomal complex that is formed by association of the U1 snRNP with the 5' splice site of an unspliced intron in an RNA transcript." [GOC:krc, ISBN:0879695897, PMID:9150140] synonym: "mammalian spliceosomal complex E" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] synonym: "mammalian spliceosomal E complex" NARROW [GOC:mah] synonym: "yeast spliceosomal complex CC" NARROW [GOC:krc, GOC:mah, ISBN:0879695897, ISBN:0879697393] is_a: GO:0005684 ! U2-type spliceosomal complex relationship: has_part GO:0005685 ! U1 snRNP [Term] id: GO:0000244 name: assembly of spliceosomal tri-snRNP namespace: biological_process alt_id: GO:0000351 alt_id: GO:0000355 def: "The formation of a tri-snRNP complex containing U4 and U6 (or U4atac and U6atac) snRNAs and U5 snRNAs and associated proteins. This includes reannealing of U4 and U6 (or U4atac and U6atac) snRNAs released from previous rounds of splicing to reform the U4/U6 snRNP (or U4atac/U6atac snRNP) as well as the subsequent association of the U5 snRNP with the U4/U6 snRNP (or U4atac/U6atac snRNP) to form a tri-snRNP that is ready to reassemble into another spliceosome complex." [ISBN:0879695897, PMID:9452384] synonym: "assembly of spliceosomal tri-snRNP U4/U6.U5" NARROW [] synonym: "assembly of spliceosomal tri-snRNP U4atac/U6atac.U5" NARROW [] synonym: "snRNP recycling" BROAD [] synonym: "spliceosomal tri-snRNP assembly" EXACT [] synonym: "spliceosomal tri-snRNP U4/U6.U5 assembly" NARROW [] synonym: "spliceosomal tri-snRNP U4atac/U6atac.U5 assembly" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000387 ! spliceosomal snRNP assembly [Term] id: GO:0000245 name: spliceosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of the spliceosome, a ribonucleoprotein apparatus that catalyzes nuclear mRNA splicing via transesterification reactions." [PMID:9476892] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000246 name: delta24(24-1) sterol reductase activity namespace: molecular_function def: "Catalysis of the reaction: ergosterol + NADP+ = ergosta-5,7,22,24(241)-tetraen-3-beta-ol + NADPH + H+." [EC:1.3.1.71, PMID:10722850] subset: gosubset_prok synonym: "C-24(28) sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "D24(24-1)-sterol reductase activity" EXACT [] synonym: "delta24(241)-sterol reductase activity" EXACT [EC:1.3.1.71] synonym: "ergosterol:NADP+ delta24(241)-oxidoreductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol Delta(24(28))-reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta-24(28) methylene reductase activity" EXACT [] synonym: "sterol delta-24(28) reductase activity" EXACT [] synonym: "sterol delta24(28)-methylene reductase activity" EXACT [EC:1.3.1.71] synonym: "sterol delta24(28)-reductase activity" EXACT [EC:1.3.1.71] xref: EC:1.3.1.71 xref: MetaCyc:1.3.1.71-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0000247 name: C-8 sterol isomerase activity namespace: molecular_function def: "Catalysis of the reaction which results in unsaturation at C-7 in the B ring of sterols." [MetaCyc:RXN3O-203, PMID:8988026] synonym: "delta-8-delta-7 sterol isomerase activity" EXACT [] xref: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0000248 name: C-5 sterol desaturase activity namespace: molecular_function def: "Catalysis of the reaction: 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] synonym: "sterol-C5-desaturase activity" EXACT [] xref: Reactome:22657 "C-5 sterol desaturase activity" is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000249 name: C-22 sterol desaturase activity namespace: molecular_function def: "Catalysis of the formation of the C-22(23) double bond in the sterol side chain. An example reaction is 5,7,24(28)-ergostatrienol + O2 + NADPH = 5,7,22,24(28)-ergostatetraenol + 2 H2O + NADP+." [MetaCyc:RXN3O-227] is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water is_a: GO:0070704 ! sterol desaturase activity [Term] id: GO:0000250 name: lanosterol synthase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2,3-epoxysqualene = lanosterol. This is a cyclization reaction that forms the sterol nucleus." [EC:5.4.99.7] subset: gosubset_prok synonym: "(S)-2,3-epoxysqualene mutase (cyclizing, lanosterol-forming)" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "2,3-epoxysqualene-lanosterol cyclase activity" EXACT [] synonym: "2,3-oxidosqualene sterol cyclase activity" BROAD [EC:5.4.99.7] synonym: "2,3-oxidosqualene-lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "lanosterol 2,3-oxidosqualene cyclase activity" EXACT [EC:5.4.99.7] synonym: "OSC" EXACT [] synonym: "oxidosqualene--lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "oxidosqualene-lanosterol cyclase activity" EXACT [] synonym: "oxidosqualene:lanosterol cyclase activity" EXACT [PMID:18033581] synonym: "squalene 2,3-epoxide:lanosterol cyclase activity" EXACT [EC:5.4.99.7] synonym: "squalene epoxidase-cyclase activity" BROAD [EC:5.4.99.7] synonym: "squalene-2,3-oxide-lanosterol cyclase activity" EXACT [EC:5.4.99.7] xref: EC:5.4.99.7 xref: MetaCyc:LANOSTEROL-SYNTHASE-RXN xref: Reactome:22668 "lanosterol synthase activity" is_a: GO:0031559 ! oxidosqualene cyclase activity [Term] id: GO:0000252 name: C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-4-beta-methyl-5-alpha-cholesta-8,24-dien-4-alpha-carboxylate + NAD(P)+ = 4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-one + CO2 + NAD(P)H." [EC:1.1.1.170, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3beta-hydroxy-4alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [EC:1.1.1.170] synonym: "3beta-hydroxy-4beta-methyl-5alpha-cholest-7-ene-4alpha-carboxylate:NAD(P)+ 3-oxidoreductase (decarboxylating)" EXACT [] synonym: "3beta-hydroxy-4beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating)" RELATED [] synonym: "3beta-hydroxy-4beta-methylcholestenoate dehydrogenase activity" RELATED [] synonym: "C-3 sterol dehydrogenase (C-4 decarboxylase) activity" RELATED [] synonym: "C-3 sterol dehydrogenase activity" RELATED [] synonym: "sterol 4alpha-carboxylic decarboxylase activity" RELATED [] synonym: "sterol-4-carboxylate 3-dehydrogenase (decarboxylating) activity" RELATED [] synonym: "sterol-4alpha-carboxylate 3-dehydrogenase (decarboxylating)" RELATED [] xref: EC:1.1.1.- xref: Reactome:22670 "C-3 sterol dehydrogenase (C-4 sterol decarboxylase) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000253 name: 3-keto sterol reductase activity namespace: molecular_function alt_id: GO:0050576 def: "Catalysis of the reaction: a 3-beta-hydroxyl sterol + NADP+ = a 3-keto sterol + NADPH + H+." [EC:1.1.1.270, GOC:mah, MetaCyc:1.1.1.270-RXN, MetaCyc:RXN3O-4110, MetaCyc:RXN66-19, MetaCyc:RXN66-24, MetaCyc:RXN66-314, MetaCyc:RXN66-319, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "3-keto-steroid reductase activity" EXACT [] synonym: "3-KSR activity" EXACT [EC:1.1.1.270] synonym: "3beta-hydroxy-steroid:NADP+ 3-oxidoreductase" RELATED [EC:1.1.1.270] xref: EC:1.1.1.270 xref: MetaCyc:1.1.1.270-RXN xref: MetaCyc:RXN3O-4110 xref: MetaCyc:RXN66-19 xref: MetaCyc:RXN66-24 xref: MetaCyc:RXN66-314 xref: MetaCyc:RXN66-319 xref: Reactome:22671 "3-keto sterol reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000254 name: C-4 methylsterol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4,4-dimethyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)H + H+ + O2 = 4-beta-hydroxymethyl-4-alpha-methyl-5-alpha-cholesta-8,24-dien-3-beta-ol + NAD(P)+ + H2O." [EC:1.14.13.72, PMID:9811880] comment: Note that zymosterol is cholesta-8,24-dien-3-ol. synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,hydrogen-donor:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4,4-dimethyl-5alpha-cholest-7-en-3beta-ol,NAD(P)H:oxygen oxidoreductase (hydroxylating)" EXACT [EC:1.14.13.72] synonym: "4-methylsterol oxidase activity" EXACT [] synonym: "methylsterol hydroxylase activity" RELATED [] synonym: "methylsterol monooxygenase activity" RELATED [] xref: EC:1.14.13.72 xref: MetaCyc:1.14.13.72-RXN xref: Reactome:22672 "C-4 methylsterol oxidase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0000255 name: allantoin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving allantoin, (2,5-dioxo-4-imidazolidinyl)urea, an intermediate or end product of purine catabolism." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0000256 name: allantoin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of allantoin, (2,5-dioxo-4-imidazolidinyl)urea." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "allantoin breakdown" EXACT [] synonym: "allantoin catabolism" EXACT [] synonym: "allantoin degradation" EXACT [] is_a: GO:0000255 ! allantoin metabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0000257 name: nitrilase activity namespace: molecular_function def: "Catalysis of the reaction: a nitrile + H2O = a carboxylate + NH3. Acts on a wide range of aromatic nitriles including (indole-3-yl)-acetonitrile and some aliphatic nitriles, and on the corresponding acid amides." [EC:3.5.5.1, GOC:kd] subset: gosubset_prok synonym: "acetonitrilase activity" EXACT [EC:3.5.5.1] synonym: "benzonitrilase activity" EXACT [EC:3.5.5.1] synonym: "nitrile aminohydrolase activity" EXACT [EC:3.5.5.1] xref: EC:3.5.5.1 xref: MetaCyc:3.5.5.1-RXN xref: UM-BBD_enzymeID:e0283 is_a: GO:0016815 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in nitriles [Term] id: GO:0000258 name: isoleucine/valine:sodium symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (isoleucine or valine)(out) + Na+(out) = (isoleucine or valine)(in) + Na+(in)." [TC:2.A.26.1.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0005283 consider: GO:0005304 consider: GO:0015188 [Term] id: GO:0000259 name: intracellular nucleoside transmembrane transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose (a deoxyribonucleotide) within a cell." [GOC:ai] comment: This term was made obsolete because it contains component and function information. is_obsolete: true replaced_by: GO:0005337 replaced_by: GO:0005622 [Term] id: GO:0000260 name: hydrogen-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.1, TC:3.A.2.2.3] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046961 [Term] id: GO:0000261 name: sodium-translocating V-type ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out). Found in vacuoles of eukaryotes and in bacteria." [TC:3.A.2.2.2] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0046962 [Term] id: GO:0000262 name: mitochondrial chromosome namespace: cellular_component def: "A chromosome found in the mitochondrion of a eukaryotic cell." [GOC:mah] synonym: "mitochondrial DNA" NARROW [] synonym: "mitochondrial genome" RELATED [] synonym: "mtDNA" NARROW [] xref: NIF_Subcellular:sao1186327184 is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0042645 ! mitochondrial nucleoid [Term] id: GO:0000263 name: heterotrimeric G-protein GTPase, alpha-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase that contains the guanine nucleotide binding site and possesses GTPase activity." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000264 name: heterotrimeric G-protein GTPase, beta-subunit namespace: molecular_function def: "OBSOLETE. Subunit of a heterotrimeric G-protein GTPase; associates tightly with the gamma subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000265 name: heterotrimeric G-protein GTPase, gamma-subunit namespace: molecular_function def: "OBSOLETE. Smallest subunit of a heterotrimeric G-protein GTPase; associates tightly with the beta subunit." [GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003924 consider: GO:0005834 [Term] id: GO:0000266 name: mitochondrial fission namespace: biological_process def: "The division of a mitochondrion within a cell to form two or more separate mitochondrial compartments." [PMID:11038192] synonym: "mitochondrial division" EXACT [] synonym: "mitochondrial proliferation" RELATED [] is_a: GO:0048285 ! organelle fission is_a: GO:0070584 ! mitochondrion morphogenesis [Term] id: GO:0000267 name: cell fraction namespace: cellular_component def: "A generic term for parts of cells prepared by disruptive biochemical techniques." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_pir subset: gosubset_prok is_a: GO:0044464 ! cell part [Term] id: GO:0000268 name: peroxisome targeting sequence binding namespace: molecular_function alt_id: GO:0005051 def: "Interacting selectively and non-covalently with a peroxisomal targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome." [GOC:mah, ISBN:0879693568] synonym: "peroxisome targeting signal receptor" NARROW [] synonym: "PTS binding" EXACT [] synonym: "PTS receptor" NARROW [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0000269 name: toxin export channel activity namespace: molecular_function def: "Enables the energy independent passage of toxins, sized less than 1000 Da, across a membrane towards the outside of the cell. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria." [GOC:mtg_transport] is_a: GO:0015288 ! porin activity is_a: GO:0019534 ! toxin transporter activity [Term] id: GO:0000270 name: peptidoglycan metabolic process namespace: biological_process alt_id: GO:0009284 def: "The chemical reactions and pathways involving peptidoglycans, any of a class of glycoconjugates found only in bacterial cell walls and consisting of strands of glycosaminoglycan cross-linked by oligopeptides to form a huge and rigid network." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein metabolic process" EXACT [] synonym: "murein metabolism" EXACT [] synonym: "peptidoglycan metabolism" EXACT [] is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0000271 name: polysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "glycan biosynthesis" EXACT [] synonym: "glycan biosynthetic process" EXACT [] synonym: "polysaccharide anabolism" EXACT [] synonym: "polysaccharide biosynthesis" EXACT [] synonym: "polysaccharide formation" EXACT [] synonym: "polysaccharide synthesis" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009059 ! macromolecule biosynthetic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0000272 name: polysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polysaccharides, polymers of more than 10 monosaccharide residues joined by glycosidic linkages." [GOC:go_curators] subset: gosubset_prok synonym: "polysaccharide breakdown" EXACT [] synonym: "polysaccharide catabolism" EXACT [] synonym: "polysaccharide degradation" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0000273 name: lipoic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "lipoic acid metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0000274 name: mitochondrial proton-transporting ATP synthase, stator stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; is thought to prevent futile rotation of the catalytic core." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045265 ! proton-transporting ATP synthase, stator stalk intersection_of: GO:0045265 ! proton-transporting ATP synthase, stator stalk intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000276 ! mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) [Term] id: GO:0000275 name: mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) namespace: cellular_component def: "The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the mitochondrial inner membrane when the entire ATP synthase is assembled." [GOC:mtg_sensu, PMID:10838056] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "hydrogen-transporting ATP synthase, F1 sector" BROAD [] synonym: "proton-transporting ATP synthase complex, catalytic core F(1)" BROAD [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) intersection_of: GO:0045261 ! proton-transporting ATP synthase complex, catalytic core F(1) intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000276 name: mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) namespace: cellular_component def: "All non-F1 subunits of the mitochondrial hydrogen-transporting ATP synthase, including integral and peripheral mitochondrial inner membrane proteins." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) intersection_of: GO:0045263 ! proton-transporting ATP synthase complex, coupling factor F(o) intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005753 ! mitochondrial proton-transporting ATP synthase complex [Term] id: GO:0000277 name: [cytochrome c]-lysine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + cytochrome c L-lysine = S-adenosyl-L-homocysteine + cytochrome c N6-methyl-L-lysine. This is the addition of a methyl group to the N6 atom of a lysine residue in cytochrome c." [EC:2.1.1.59] synonym: "cytochrome c (lysine) methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-lysine N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein methylase III activity" EXACT [EC:2.1.1.59] synonym: "cytochrome c-specific protein-lysine methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine 6-N-methyltransferase activity" EXACT [EC:2.1.1.59] synonym: "S-adenosyl-L-methionine:cytochrome c-L-lysine N6-methyltransferase activity" EXACT [EC:2.1.1.59] xref: EC:2.1.1.59 xref: MetaCyc:2.1.1.59-RXN is_a: GO:0016279 ! protein-lysine N-methyltransferase activity [Term] id: GO:0000278 name: mitotic cell cycle namespace: biological_process def: "Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent." [GOC:mah, ISBN:0815316194, Reactome:69278] xref: Reactome:562725 "Cell Cycle, Mitotic" xref: Reactome:588345 "Cell Cycle, Mitotic" xref: Reactome:609088 "Cell Cycle, Mitotic" xref: Reactome:633783 "Cell Cycle, Mitotic" xref: Reactome:645386 "Cell Cycle, Mitotic" xref: Reactome:655754 "Cell Cycle, Mitotic" xref: Reactome:660987 "Cell Cycle, Mitotic" xref: Reactome:666766 "Cell Cycle, Mitotic" xref: Reactome:672874 "Cell Cycle, Mitotic" xref: Reactome:678588 "Cell Cycle, Mitotic" xref: Reactome:683546 "Cell Cycle, Mitotic" xref: Reactome:689752 "Cell Cycle, Mitotic" xref: Reactome:69278 "Cell Cycle, Mitotic" xref: Reactome:701483 "Cell Cycle, Mitotic" xref: Reactome:716054 "Cell Cycle, Mitotic" xref: Reactome:720693 "Cell Cycle, Mitotic" xref: Reactome:728005 "Cell Cycle, Mitotic" xref: Reactome:730935 "Cell Cycle, Mitotic" xref: Reactome:733035 "Cell Cycle, Mitotic" xref: Reactome:733877 "Cell Cycle, Mitotic" xref: Reactome:735598 "Cell Cycle, Mitotic" xref: Reactome:736605 "Cell Cycle, Mitotic" xref: Reactome:738509 "Cell Cycle, Mitotic" is_a: GO:0007049 ! cell cycle [Term] id: GO:0000279 name: M phase namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through M phase, the part of the cell cycle comprising nuclear division." [GOC:dph, GOC:mah, ISBN:0815316194] synonym: "M-phase" EXACT [] xref: Wikipedia:M_phase is_a: GO:0022403 ! cell cycle phase [Term] id: GO:0000280 name: nuclear division namespace: biological_process def: "A process by which a cell nucleus is divided into two nuclei, with DNA and other nuclear contents distributed between the daughter nuclei." [GOC:mah] subset: goslim_pir synonym: "karyokinesis" RELATED [] is_a: GO:0048285 ! organelle fission [Term] id: GO:0000281 name: cytokinesis after mitosis namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after mitosis, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000282 name: cellular bud site selection namespace: biological_process def: "The specification of the site where a daughter cell will form, in organisms that reproduce by budding. An example of this process is found in Saccharomyces cerevisiae." [GOC:mah] comment: Note that this term was split from 'bud site selection/establishment of cell polarity (sensu Saccharomyces) ; GO:0007115' (a sibling term, 'establishment of cell polarity (sensu Saccharomyces) ; GO:0000283', was created but has since been merged with 'establishment of cell polarity' ; GO:0030010). synonym: "bud site selection/establishment of cell polarity" BROAD [] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000284 name: shmoo orientation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it is an organism specific term. The entire branch of the ontology was reorganized to be more generally applicable. is_obsolete: true replaced_by: GO:0000753 [Term] id: GO:0000285 name: 1-phosphatidylinositol-3-phosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 3-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate." [EC:2.7.1.150] synonym: "ATP:1-phosphatidyl-1D-myo-inositol-3-phosphate 5-phosphotransferase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol 3-phosphate 5-kinase activity" EXACT [EC:2.7.1.150] synonym: "phosphatidylinositol-3-phosphate 5-kinase activity" EXACT [] synonym: "type III PIP kinase activity" RELATED [EC:2.7.1.150] xref: EC:2.7.1.150 xref: MetaCyc:2.7.1.150-RXN is_a: GO:0016307 ! phosphatidylinositol phosphate kinase activity [Term] id: GO:0000286 name: alanine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + H2O + NAD+ = pyruvate + NH3 + NADH + H+." [EC:1.4.1.1] subset: gosubset_prok synonym: "AlaDH" RELATED [EC:1.4.1.1] synonym: "alanine oxidoreductase activity" EXACT [EC:1.4.1.1] synonym: "alpha-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "L-alanine:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.1] synonym: "NAD-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NAD-linked alanine dehydrogenase activity" EXACT [EC:1.4.1.1] synonym: "NADH-dependent alanine dehydrogenase activity" EXACT [EC:1.4.1.1] xref: EC:1.4.1.1 xref: MetaCyc:ALANINE-DEHYDROGENASE-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0000287 name: magnesium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with magnesium (Mg) ions." [GOC:ai] subset: gosubset_prok synonym: "magnesium binding" EXACT [] is_a: GO:0046872 ! metal ion binding [Term] id: GO:0000288 name: nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay namespace: biological_process def: "A major pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of ordered steps that includes poly(A) tail shortening and that can regulate mRNA stability." [GOC:jp, GOC:krc] synonym: "deadenylation-dependent mRNA decay" EXACT [] synonym: "mRNA breakdown, deadenylation-dependent decay" EXACT [] synonym: "mRNA catabolic process, deadenylation-dependent" EXACT [] synonym: "mRNA catabolic process, deadenylylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylation-dependent" EXACT [] synonym: "mRNA catabolism, deadenylylation-dependent" EXACT [] synonym: "mRNA degradation, deadenylation-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, deadenylation-dependent decay" EXACT [] xref: Reactome:429914 "Deadenylation-dependent mRNA decay" xref: Reactome:562609 "Deadenylation-dependent mRNA decay" xref: Reactome:588235 "Deadenylation-dependent mRNA decay" xref: Reactome:609660 "Deadenylation-dependent mRNA decay" xref: Reactome:633681 "Deadenylation-dependent mRNA decay" xref: Reactome:645291 "Deadenylation-dependent mRNA decay" xref: Reactome:655667 "Deadenylation-dependent mRNA decay" xref: Reactome:660949 "Deadenylation-dependent mRNA decay" xref: Reactome:666733 "Deadenylation-dependent mRNA decay" xref: Reactome:672821 "Deadenylation-dependent mRNA decay" xref: Reactome:678544 "Deadenylation-dependent mRNA decay" xref: Reactome:683506 "Deadenylation-dependent mRNA decay" xref: Reactome:689705 "Deadenylation-dependent mRNA decay" xref: Reactome:701438 "Deadenylation-dependent mRNA decay" xref: Reactome:716009 "Deadenylation-dependent mRNA decay" xref: Reactome:720764 "Deadenylation-dependent mRNA decay" xref: Reactome:727959 "Deadenylation-dependent mRNA decay" xref: Reactome:731014 "Deadenylation-dependent mRNA decay" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000289 name: nuclear-transcribed mRNA poly(A) tail shortening namespace: biological_process def: "Shortening of the poly(A) tail of a nuclear-transcribed mRNA from full length to an oligo(A) length." [GOC:krc] synonym: "3' to 5' mRNA deadenylation" RELATED [] synonym: "mRNA deadenylation" RELATED [] synonym: "nuclear mRNA poly(A) tail shortening" RELATED [] xref: Reactome:429947 "Deadenylation of mRNA" xref: Reactome:563093 "Deadenylation of mRNA" xref: Reactome:588704 "Deadenylation of mRNA" xref: Reactome:609659 "Deadenylation of mRNA" xref: Reactome:634143 "Deadenylation of mRNA" xref: Reactome:645653 "Deadenylation of mRNA" xref: Reactome:661289 "Deadenylation of mRNA" xref: Reactome:667066 "Deadenylation of mRNA" xref: Reactome:673215 "Deadenylation of mRNA" xref: Reactome:678899 "Deadenylation of mRNA" is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process is_a: GO:0031124 ! mRNA 3'-end processing relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000290 name: deadenylation-dependent decapping of nuclear-transcribed mRNA namespace: biological_process def: "Cleavage of the 5'-cap of a nuclear mRNA triggered by shortening of the poly(A) tail to below a minimum functional length." [GOC:krc] synonym: "deadenylation-dependent decapping of nuclear mRNA" EXACT [] synonym: "deadenylylation-dependent decapping" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process relationship: part_of GO:0000288 ! nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay [Term] id: GO:0000291 name: nuclear-transcribed mRNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the transcript body of a nuclear-transcribed mRNA that occurs when the ends are not protected by the 5'-cap or the 3'-poly(A) tail." [GOC:krc] synonym: "exonucleolytic degradation of mRNA" EXACT [] synonym: "mRNA breakdown, exonucleolytic" EXACT [] synonym: "mRNA degradation, exonucleolytic" EXACT [] synonym: "nuclear mRNA catabolic process, exonucleolytic" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000292 name: RNA fragment catabolic process namespace: biological_process alt_id: GO:0030452 def: "The chemical reactions and pathways resulting in the breakdown of a fragment of RNA, such as excised introns or sequences removed from ribosomal RNA during processing." [GOC:mah] subset: gosubset_prok synonym: "group I intron catabolic process" NARROW [] synonym: "RNA fragment breakdown" EXACT [] synonym: "RNA fragment catabolism" EXACT [GOC:mah] synonym: "RNA fragment degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000293 name: ferric-chelate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 Fe2+ + NAD+ = 2 Fe3+ + NADH + H+." [EC:1.16.1.7] comment: Note that this function was formerly EC:1.6.99.13. synonym: "Fe(II):NAD+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "ferric chelate reductase activity" EXACT [EC:1.16.1.7] synonym: "iron chelate reductase activity" RELATED [EC:1.16.1.7] synonym: "NADH2:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+) oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe(3+)-EDTA reductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+ oxidoreductase activity" EXACT [EC:1.16.1.7] synonym: "NADH:Fe3+-EDTA reductase activity" EXACT [EC:1.16.1.7] xref: EC:1.16.1.7 xref: MetaCyc:FERRIC-CHELATE-REDUCTASE-RXN is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0000294 name: nuclear-transcribed mRNA catabolic process, endonucleolytic cleavage-dependent decay namespace: biological_process def: "A minor degradation pathway nuclear-transcribed mRNAs that begins with an endonucleolytic cleavage to generate unprotected ends." [GOC:krc] synonym: "endonucleolytic mRNA decay" EXACT [] synonym: "mRNA breakdown, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "mRNA catabolic process, endonucleolytic" EXACT [] synonym: "mRNA catabolism, endonucleolytic" EXACT [] synonym: "mRNA degradation, endonucleolytic cleavage-dependent decay" EXACT [] synonym: "nuclear mRNA catabolic process, endonucleolytic cleavage-dependent decay" EXACT [] is_a: GO:0000956 ! nuclear-transcribed mRNA catabolic process [Term] id: GO:0000295 name: adenine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of adenine nucleotides (AMP, ADP, and ATP) from one side of the membrane to the other." [PMID:11566870] xref: Reactome:22791 "adenine nucleotide transmembrane transporter activity" is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity relationship: part_of GO:0051503 ! adenine nucleotide transport [Term] id: GO:0000296 name: spermine transport namespace: biological_process def: "The directed movement of spermine, N,N-bis(3-aminopropyl)-1,4-diaminobutane, a polyamine formed by the transfer of a propylamine group from decarboxylated S-adenosylmethionine to spermidine, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0015846 ! polyamine transport [Term] id: GO:0000297 name: spermine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of spermine from one side of the membrane to the other. Spermine is a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [GOC:ai] is_a: GO:0015203 ! polyamine transmembrane transporter activity relationship: part_of GO:0000296 ! spermine transport [Term] id: GO:0000298 name: endopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate + n H2O = (n+1) oligophosphate. The product contains 4 or 5 phosphate residues." [EC:3.6.1.10] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polymetaphosphatase activity" EXACT [EC:3.6.1.10] synonym: "polyphosphatase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate depolymerase activity" BROAD [EC:3.6.1.10] synonym: "polyphosphate polyphosphohydrolase activity" EXACT [EC:3.6.1.10] xref: EC:3.6.1.10 xref: MetaCyc:ENDOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000299 name: integral to membrane of membrane fraction namespace: cellular_component def: "Integral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; require detergents, such as Triton X-100, to be released from membranes." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000300 name: peripheral to membrane of membrane fraction namespace: cellular_component def: "Peripheral to that fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes; can be extracted from membrane fraction with high concentrations of salt or high pH." [PMID:10512869] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. is_a: GO:0005624 ! membrane fraction [Term] id: GO:0000301 name: retrograde transport, vesicle recycling within Golgi namespace: biological_process def: "The retrograde movement of substances within the Golgi, mediated by COP I vesicles. Cis-Golgi vesicles are constantly moving forward through the Golgi stack by cisternal progression, eventually becoming trans-Golgi vesicles. They then selectively transport membrane and luminal proteins from the trans- to the medial-Golgi while leaving others behind in the trans-Golgi cisternae; similarly, they selectively move proteins from the medial- to the cis-Golgi." [ISBN:0716731363] synonym: "retrograde (vesicle recycling within Golgi) transport" EXACT [] is_a: GO:0006891 ! intra-Golgi vesicle-mediated transport [Term] id: GO:0000302 name: response to reactive oxygen species namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals." [GOC:krc] subset: gosubset_prok synonym: "response to active oxygen species" EXACT [] synonym: "response to AOS" EXACT [] synonym: "response to reactive oxidative species" EXACT [] synonym: "response to reactive oxygen intermediate" EXACT [] synonym: "response to ROI" EXACT [] synonym: "response to ROS" EXACT [] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0000303 name: response to superoxide namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a superoxide stimulus. Superoxide is the anion, oxygen-, formed by addition of one electron to dioxygen (O2) or any compound containing the superoxide anion." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0000305 ! response to oxygen radical [Term] id: GO:0000304 name: response to singlet oxygen namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a singlet oxygen stimulus. Singlet oxygen is a dioxygen (O2) molecule in which two 2p electrons have similar spin. Singlet oxygen is more highly reactive than the form in which these electrons are of opposite spin, and it is produced in mutant chloroplasts lacking carotenoids and by leukocytes during metabolic burst." [GOC:krc, ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000305 name: response to oxygen radical namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an oxygen radical stimulus. An oxygen radical is any oxygen species that carries a free electron; examples include hydroxyl radicals and the superoxide anion." [GOC:krc, ISBN:0124325653] subset: gosubset_prok is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0000306 name: extrinsic to vacuolar membrane namespace: cellular_component def: "Loosely bound to one or the other surface of the vacuolar membrane, but not integrated into the hydrophobic region." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044437 ! vacuolar part relationship: part_of GO:0005774 ! vacuolar membrane [Term] id: GO:0000307 name: cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinases (CDKs) are heterodimeric enzymes that contain a kinase catalytic subunit associated with a regulatory cyclin partner." [GOC:krc, PMID:11602261] subset: goslim_pir synonym: "CDK holoenzyme" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000308 name: cytoplasmic cyclin-dependent protein kinase holoenzyme complex namespace: cellular_component def: "Cyclin-dependent protein kinase (CDK) complex found in the cytoplasm." [GOC:krc] synonym: "CDK holoenzyme" BROAD [] is_a: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000307 ! cyclin-dependent protein kinase holoenzyme complex intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0000309 name: nicotinamide-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide nucleotide = diphosphate + NAD+." [EC:2.7.7.1] subset: gosubset_prok synonym: "adenosine triphosphate-nicotinamide mononucleotide transadenylase activity" EXACT [EC:2.7.7.1] synonym: "ATP:nicotinamide-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:NMN adenylyltransferase activity" EXACT [EC:2.7.7.1] synonym: "diphosphopyridine nucleotide pyrophosphorylase activity" RELATED [EC:2.7.7.1] synonym: "NAD(+) diphosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD(+) pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "NAD+ diphosphorylase activity" EXACT [EC:2.7.7.1] synonym: "NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.1] synonym: "nicotinamide adenine dinucleotide pyrophosphorylase activity" NARROW [EC:2.7.7.1] synonym: "nicotinamide mononucleotide adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMN adenylyltransferase activity" NARROW [EC:2.7.7.1] synonym: "NMNAT activity" NARROW [EC:2.7.7.1] xref: EC:2.7.7.1 xref: MetaCyc:2.7.7.1-RXN xref: Reactome:23250 "nicotinamide-nucleotide adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0000310 name: xanthine phosphoribosyltransferase activity namespace: molecular_function alt_id: GO:0009043 def: "Catalysis of the reaction: 5-phospho-alpha-D-ribose 1-diphosphate + xanthine = (9-D-ribosylxanthine)-5'-phosphate + diphosphate; substrate specificity for xanthine." [EC:2.4.2.22, GOC:clt] subset: gosubset_prok synonym: "5-phospho-alpha-D-ribose-1-diphosphate:xanthine phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "Xan phosphoribosyltransferase activity" EXACT [EC:2.4.2.22] synonym: "xanthine-guanine phosphoribosyltransferase activity" EXACT [] synonym: "xanthosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylate pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "xanthylic pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP pyrophosphorylase activity" EXACT [EC:2.4.2.22] synonym: "XMP:diphosphate 5-phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.22] xref: EC:2.4.2.22 xref: MetaCyc:XANPRIBOSYLTRAN-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0000311 name: plastid large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a plastid ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044435 ! plastid part intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0009547 ! plastid ribosome relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000312 name: plastid small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a plastid ribosome." [GOC:mcc] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044435 ! plastid part intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0009547 ! plastid ribosome relationship: part_of GO:0009547 ! plastid ribosome [Term] id: GO:0000313 name: organellar ribosome namespace: cellular_component def: "A ribosome contained within a subcellular membrane-bounded organelle." [GOC:mah, GOC:mcc] is_a: GO:0005840 ! ribosome is_a: GO:0044422 ! organelle part intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0043226 ! organelle [Term] id: GO:0000314 name: organellar small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of an organellar ribosome." [GOC:mcc] is_a: GO:0015935 ! small ribosomal subunit intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0000313 ! organellar ribosome relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000315 name: organellar large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of an organellar ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] is_a: GO:0015934 ! large ribosomal subunit intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0000313 ! organellar ribosome relationship: part_of GO:0000313 ! organellar ribosome [Term] id: GO:0000316 name: sulfite transport namespace: biological_process def: "The directed movement of sulfite into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] synonym: "sulphite transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0000317 name: methionine-S-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine S-oxide + thioredoxin = L-methionine + thioredoxin disulfide. Thioredoxin disulfide is the oxidized form of thioredoxin. No reaction on oxidized methionine in peptide linkage." [PMID:11169920] subset: gosubset_prok synonym: "methionine sulfoxide reductase activity" EXACT [] is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0000318 name: protein-methionine-R-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-methionine R-oxide + thioredoxin = L-methionine + thioredoxin disulfide; can act on oxidized methionine in peptide linkage with specificity for the R enantiomer. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.8.4.-, PMID:11929995] subset: gosubset_prok xref: EC:1.8.4.- is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0000319 name: sulfite transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of sulfite ions from one side of a membrane to the other." [GOC:as] synonym: "sulphite transporter activity" EXACT [] is_a: GO:0015103 ! inorganic anion transmembrane transporter activity relationship: part_of GO:0000316 ! sulfite transport [Term] id: GO:0000320 name: re-entry into mitotic cell cycle namespace: biological_process def: "The resumption of the mitotic cell division cycle by cells that were in a quiescent or other non-dividing state." [GOC:krc] is_a: GO:0022402 ! cell cycle process [Term] id: GO:0000321 name: re-entry into mitotic cell cycle after pheromone arrest namespace: biological_process def: "The resumption of the mitotic cell division cycle by pheromone-arrested cells that have not mated. An example of this process is found in Saccharomyces cerevisiae." [GOC:krc, PMID:9927449] is_a: GO:0000320 ! re-entry into mitotic cell cycle is_a: GO:0000754 ! adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion is_a: GO:0048610 ! reproductive cellular process [Term] id: GO:0000322 name: storage vacuole namespace: cellular_component def: "A vacuole that functions primarily in the storage of materials, including nutrients, pigments, waste products, and small molecules." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000323 name: lytic vacuole namespace: cellular_component def: "A vacuole that is maintained at an acidic pH and which contains degradative enzymes, including a wide variety of acid hydrolases." [GOC:krc] is_a: GO:0005773 ! vacuole [Term] id: GO:0000324 name: fungal-type vacuole namespace: cellular_component def: "A vacuole that has both lytic and storage functions. The fungal vacuole is a large, membrane-bounded organelle that functions as a reservoir for the storage of small molecules (including polyphosphate, amino acids, several divalent cations (e.g. calcium), other ions, and other small molecules) as well as being the primary compartment for degradation. It is an acidic compartment, containing an ensemble of acid hydrolases. At least in S. cerevisiae, there are indications that the morphology of the vacuole is variable and correlated with the cell cycle, with logarithmically growing cells having a multilobed, reticulated vacuole, while stationary phase cells contain a single large structure." [GOC:mah, GOC:mtg_sensu, ISBN:0879693649] synonym: "vacuole, cell cycle-correlated morphology" EXACT [] is_a: GO:0000322 ! storage vacuole is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0000325 name: plant-type vacuole namespace: cellular_component def: "A closed structure that is completely surrounded by a unit membrane, contains liquid, and retains the same shape regardless of cell cycle phase. An example of this structure is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0815316208] synonym: "vacuole, cell cycle-independent morphology" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0000326 name: protein storage vacuole namespace: cellular_component def: "A storage vacuole that contains a lytic vacuole; identified in plants." [PMID:11739409] is_a: GO:0000322 ! storage vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0000327 name: lytic vacuole within protein storage vacuole namespace: cellular_component def: "A membrane-bounded compartment containing crystals of phytic acid and proteins characteristic of a lytic vacuole, found within a storage vacuole." [PMID:11739490] is_a: GO:0000323 ! lytic vacuole is_a: GO:0044437 ! vacuolar part intersection_of: GO:0000323 ! lytic vacuole intersection_of: part_of GO:0000326 ! protein storage vacuole relationship: part_of GO:0000326 ! protein storage vacuole [Term] id: GO:0000328 name: fungal-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole, the shape of which correlates with cell cycle phase. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000329 name: fungal-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole, the shape of which correlates with cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this structure is found in Saccharomyces cerevisiae." [GOC:krc, GOC:mtg_sensu] synonym: "fungal-type vacuolar membrane" RELATED [] synonym: "membrane of vacuole with cell cycle-correlated morphology" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000324 ! fungal-type vacuole [Term] id: GO:0000330 name: plant-type vacuole lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane of a vacuole that retains the same shape regardless of cell cycle phase. An example of this is found in Arabidopsis thaliana." [GOC:krc, GOC:mtg_sensu] synonym: "lumen of vacuole with cell cycle-independent morphology" EXACT [] is_a: GO:0005775 ! vacuolar lumen relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0000331 name: contractile vacuole namespace: cellular_component def: "A specialized vacuole of eukaryotic cells, especially Protozoa, that fills with water from the cytoplasm and then discharges this externally by the opening of contractile vacuole pores. Its function is probably osmoregulatory." [GOC:jl, http://cancerweb.ncl.ac.uk/, PMID:10503189] xref: Wikipedia:Contractile_vacuole is_a: GO:0005773 ! vacuole is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle is_a: GO:0031988 ! membrane-bounded vesicle [Term] id: GO:0000332 name: template for synthesis of G-rich strand of telomere DNA activity namespace: molecular_function def: "Provision of the template used by reverse transcriptase to synthesize the G-rich strand of telomeric DNA." [PMID:11812242] comment: Note that this term describes the activity of an RNA gene product that interacts with other nucleic acid molecules via base pairing; it should not be used to annotate proteins. synonym: "telomerase RNA" EXACT [] synonym: "telomerase, template" EXACT [] is_a: GO:0000497 ! base pairing with DNA relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0000333 name: telomerase catalytic core complex namespace: cellular_component def: "The minimal catalytic core of telomerase is a ribonucleoprotein complex composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition." [PMID:11884619] is_a: GO:0005697 ! telomerase holoenzyme complex [Term] id: GO:0000334 name: 3-hydroxyanthranilate 3,4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxyanthranilate + O2 = 2-amino-3-carboxymuconate semialdehyde." [EC:1.13.11.6] subset: gosubset_prok synonym: "3-hydroxyanthranilate oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilate:oxygen 3,4-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid dioxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic acid oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3-hydroxyanthranilic oxygenase activity" EXACT [EC:1.13.11.6] synonym: "3HAO" RELATED [EC:1.13.11.6] xref: EC:1.13.11.6 xref: MetaCyc:1.13.11.6-RXN xref: Reactome:23302 "3-hydroxyanthranilate 3,4-dioxygenase activity" xref: UM-BBD_enzymeID:e0633 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0000335 name: negative regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc, GOC:tb] subset: gosubset_prok synonym: "down regulation of DNA transposition" EXACT [] synonym: "down-regulation of DNA transposition" EXACT [] synonym: "downregulation of DNA transposition" EXACT [] synonym: "inhibition of DNA transposition" NARROW [] synonym: "negative regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010529 ! negative regulation of transposition is_a: GO:0045910 ! negative regulation of DNA recombination intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006313 ! transposition, DNA-mediated relationship: negatively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000336 name: positive regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of DNA transposition." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "activation of DNA transposition" NARROW [] synonym: "positive regulation of DNA transposition" EXACT [GOC:dph] synonym: "stimulation of DNA transposition" NARROW [] synonym: "up regulation of DNA transposition" EXACT [] synonym: "up-regulation of DNA transposition" EXACT [] synonym: "upregulation of DNA transposition" EXACT [] is_a: GO:0000337 ! regulation of transposition, DNA-mediated is_a: GO:0010530 ! positive regulation of transposition is_a: GO:0045911 ! positive regulation of DNA recombination intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006313 ! transposition, DNA-mediated relationship: positively_regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000337 name: regulation of transposition, DNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA transposition, the process of transposing (moving to a different location) a segment of a chromosome or a piece of a DNA molecule." [GOC:dph, GOC:krc] subset: gosubset_prok synonym: "regulation of DNA transposition" EXACT [GOC:dph] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0010528 ! regulation of transposition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006313 ! transposition, DNA-mediated relationship: regulates GO:0006313 ! transposition, DNA-mediated [Term] id: GO:0000338 name: protein deneddylation namespace: biological_process def: "The removal of a ubiquitin-like protein of the NEDD8 type from a protein." [GOC:krc] is_a: GO:0043687 ! post-translational protein modification is_a: GO:0070646 ! protein modification by small protein removal [Term] id: GO:0000339 name: RNA cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with a 7-methylguanosine (m7G) moiety or derivative located at the 5' end of an RNA molecule." [GOC:krc] synonym: "binding to mRNA cap" NARROW [] synonym: "mRNA cap binding" NARROW [] synonym: "snRNA cap binding" NARROW [] is_a: GO:0003723 ! RNA binding [Term] id: GO:0000340 name: RNA 7-methylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 7-methylguanosine moiety added cotranscriptionally to the 5' end of RNA molecules transcribed by polymerase II." [GOC:krc] synonym: "RNA m7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000341 name: RNA trimethylguanosine cap binding namespace: molecular_function def: "Interacting selectively and non-covalently with the trimethylguanosine (m(3)(2,2,7)-GTP) moiety located at the 5' end of some RNA molecules. Such trimethylated cap structures, generally produced by posttranscriptional modification of a 7-methylguanosine cap, are often found on snRNAs and snoRNAs transcribed by RNA polymerase II, but have also be found on snRNAs transcribed by RNA polymerase III. They have also been found on a subset of the mRNA population in some species, e.g. C. elegans." [GOC:krc] synonym: "RNA m2,2,7G cap binding" EXACT [] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000342 name: RNA cap 4 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a hypermethylated cap structure consisting of 7-methylguanosine (m(7)G) followed by four methylated nucleotides (cap 4): 7-methylguanosine-ppp-N6, N6, 2'-O-trimethyladenosine-p-2'-O-methyladenosine-p-2'-O-methylcytosine-p-N3, 2'-O-dimethyluridine Such caps are known to be found at the 5' ends of SL RNAs of trypanosomatid protozoa." [GOC:krc, PMID:10880518, PMID:12121975] is_a: GO:0000339 ! RNA cap binding [Term] id: GO:0000343 name: plastid-encoded plastid RNA polymerase complex A namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-A is generated from the PEP-B form during chloroplast maturation to generate a complex composed of at least thirteen polypeptides that is not sensitive to the antibiotic rifampicin, like its precursor form the PEP-B complex." [PMID:10946105] synonym: "PEP-A" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000344 name: plastid-encoded plastid RNA polymerase complex B namespace: cellular_component def: "A plastid-encoded DNA-directed RNA polymerase complex that resembles eubacterial multisubunit RNA polymerases with a core composed of alpha, beta, and beta-prime subunits. An additional subunit, a sigma factor, is required for promoter recognition. PEP-B is distinguished from PEP-A by its sensitivity to the antibiotic rifampicin. PEP-B is found in both etioplasts and chloroplasts, but is the predominate form in etioplasts. It forms the core of the PEP-A form; the conversion from PEP-B to PEP-A occurs during chloroplast maturation." [PMID:10946105] synonym: "PEP-B" EXACT [] is_a: GO:0000427 ! plastid-encoded plastid RNA polymerase complex [Term] id: GO:0000345 name: cytosolic DNA-directed RNA polymerase complex namespace: cellular_component def: "The eubacterial DNA-directed RNA polymerase is a multisubunit complex with a core composed of the essential subunits beta-prime, beta, and two copies of alpha and a fifth nonessential subunit called omega. An additional subunit, a sigma factor, is required for promoter recognition and specificity." [PMID:11158566] subset: gosubset_prok is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0000346 name: transcription export complex namespace: cellular_component def: "The transcription export (TREX) complex couples transcription elongation by RNA polymerase II to mRNA export. The complex associates with the polymerase and travels with it along the length of the transcribed gene. TREX is composed of the THO transcription elongation complex as well as other proteins that couple THO to mRNA export proteins. The TREX complex is known to be found in a wide range of eukaryotes, including S. cerevisiae and metazoans." [GOC:krc, PMID:11979277] subset: goslim_pir synonym: "TREX complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000347 name: THO complex namespace: cellular_component def: "The THO complex is a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. The THO complex is also part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1p, Tho2p, Thp1p, and Mft1p, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0000348 name: nuclear mRNA branch site recognition namespace: biological_process alt_id: GO:0000370 alt_id: GO:0000371 def: "Recognition of the pre-mRNA branch site sequence by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the B complex (yeast) or the A complex (mammalian). synonym: "spliceosomal A complex biosynthesis" NARROW [] synonym: "spliceosomal A complex formation" NARROW [] synonym: "spliceosomal B complex biosynthesis" NARROW [] synonym: "spliceosomal B complex formation" NARROW [] synonym: "U12-type nuclear mRNA branch site recognition" NARROW [] synonym: "U2-type nuclear mRNA branch site recognition" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly [Term] id: GO:0000349 name: generation of catalytic spliceosome for first transesterification step namespace: biological_process alt_id: GO:0000356 alt_id: GO:0000357 def: "Formation of a catalytic spliceosome complex ready to perform the first splicing reaction. This occurs by an ATP-dependent conformational change of the pre-catalytic spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents the formation of the A2-2 complex (yeast) or the C1 complex (mammalian). synonym: "catalytic spliceosome assembly for first transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for first transesterification step" EXACT [] synonym: "spliceosomal A2-2 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-2 complex formation" NARROW [] synonym: "spliceosomal C1 complex biosynthesis" NARROW [] synonym: "spliceosomal C1 complex formation" NARROW [] synonym: "U12-type catalytic spliceosome formation for first transesterification step" NARROW [] synonym: "U2-type catalytic spliceosome formation for first transesterification step" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000350 name: generation of catalytic spliceosome for second transesterification step namespace: biological_process alt_id: GO:0000358 alt_id: GO:0000359 def: "Conformational rearrangement of the spliceosomal complex containing the RNA products from the 1st step of splicing to form the catalytic site for the second step of splicing." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A2-3 complex (yeast) or the C2 complex (mammalian). synonym: "catalytic spliceosome assembly for second transesterification step" RELATED [] synonym: "formation of catalytic spliceosome for second transesterification step" EXACT [] synonym: "formation of catalytic U12-type spliceosome for second transesterification step" NARROW [] synonym: "formation of catalytic U2-type spliceosome for second transesterification step" NARROW [] synonym: "formation of spliceosomal A2-2 complex" NARROW [] synonym: "formation of spliceosomal C1 complex" NARROW [] synonym: "lariat formation, 5'-splice site cleavage" RELATED [] synonym: "spliceosomal A2-3 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-3 complex formation" NARROW [] synonym: "spliceosomal C2 complex biosynthesis" NARROW [] synonym: "spliceosomal C2 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000352 name: trans assembly of SL-containing precatalytic spliceosome namespace: biological_process def: "Assembly of a spliceosomal complex containing the SL RNA and the pre-mRNA to be joined, as well as all the spliceosomal snRNPs involved in trans leader splicing. Formation of the trans leader spliceosome brings together the quadruple SL/U4/U5/U6 snRNP and the complex of the U2 snRNP with the splice site of the pre-mRNA." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] synonym: "trans assembly of spliced leader-containing precatalytic spliceosome" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition [Term] id: GO:0000353 name: formation of quadruple SL/U4/U5/U6 snRNP namespace: biological_process def: "Formation of a quadruple snRNP complex composed of the spliced leader (SL) RNA along with the U4/U6-U5 tri-snRNP complex. Interactions that may facilitate this include a duplex between the SL and U6 RNAs and interactions between the U5 RNA and the exon sequence at the 5' splice site within the SL RNA." [GOC:krc, ISBN:0879695897] comment: Note that this step is analogous to 5' splice site selection in cis-splicing. is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0045291 ! nuclear mRNA trans splicing, SL addition [Term] id: GO:0000354 name: cis assembly of pre-catalytic spliceosome namespace: biological_process alt_id: GO:0000360 alt_id: GO:0000361 def: "Assembly of a spliceosomal complex containing the intact pre-mRNA and all of the spliceosomal snRNPs. This occurs when the tri-snRNP associates with the pre-mRNA and associated snRNPs in an ATP-dependent manner." [GOC:krc, GOC:mtg_mpo, ISBN:0879695897] comment: Note that this step represents formation of the A2-1 complex (yeast) or the B1 complex (mammals). synonym: "cis assembly of U12-type pre-catalytic spliceosome" NARROW [] synonym: "cis assembly of U2-type pre-catalytic spliceosome" NARROW [] synonym: "formation of spliceosomal A2-1 complex" NARROW [] synonym: "formation of spliceosomal B1 complex" NARROW [] synonym: "spliceosomal A2-1 complex biosynthesis" NARROW [] synonym: "spliceosomal A2-1 complex formation" NARROW [] synonym: "spliceosomal B1 complex biosynthesis" NARROW [] synonym: "spliceosomal B1 complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome [Term] id: GO:0000362 name: first U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U2-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6 and/or U2 snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000363 name: first U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the first transesterification reaction of U12-type spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, which is still joined to the 3' exon. The catalytic site is thought to be formed by U6atac snRNA and/or U2atac snRNA, and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "lariat formation, 5'-splice site cleavage" BROAD [] is_obsolete: true replaced_by: GO:0000384 [Term] id: GO:0000364 name: second U2-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U2-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000365 name: nuclear mRNA trans splicing, via spliceosome namespace: biological_process def: "The joining together of exons from two different primary transcripts of messenger RNA (mRNA) via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0879695897] synonym: "nuclear mRNA trans splicing, via U2-type spliceosome" NARROW [] is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000366 name: intergenic nuclear mRNA trans splicing namespace: biological_process def: "The joining together of two independently transcribed RNAs from two different genes, each of which also produces mRNA(s) via cis-splicing." [GOC:krc, PMID:11726664, PMID:12110900] is_a: GO:0000365 ! nuclear mRNA trans splicing, via spliceosome is_a: GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome [Term] id: GO:0000367 name: second U12-type spliceosomal transesterification activity namespace: molecular_function def: "OBSOLETE. Catalysis of the second transesterification reaction of U12-type spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure. The catalytic site is thought to be formed by U6 and/or U2 snRNAs and/or associated proteins." [GOC:krc, ISBN:0879695897] comment: This term was made obsolete because the activities used in the U2- and U12-type complexes are the same. The cellular component ontology should (and does) represent the two different complexes, but the molecular function ontology should not. synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_obsolete: true replaced_by: GO:0000386 [Term] id: GO:0000372 name: Group I intron splicing namespace: biological_process def: "The splicing of Group I introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group I introns and involved in determining the locations of the splice sites (there do not appear to be consensus splice site sequences) as well as having a role in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions, generally with exogenous guanosine as the initiating nucleophile. The intron is excised as a linear piece (though it may subsequently circularize)." [GOC:krc, PMID:11377794] comment: Note that Group I introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; tRNA and mRNA of bacteria and bacteriophage; rRNA of protists and fungi; and occasionally in mRNA of animal mitochondria (e.g. sea anemone). subset: gosubset_prok synonym: "mRNA splicing" NARROW [] is_a: GO:0000376 ! RNA splicing, via transesterification reactions with guanosine as nucleophile [Term] id: GO:0000373 name: Group II intron splicing namespace: biological_process def: "The splicing of Group II introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group II introns and containing splice site consensus sequences, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions (mechanistically similar to those for splicing of nuclear mRNAs) initiated by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat." [GOC:krc, PMID:11377794] comment: Note that Group II introns are known to be found in a number of places: rRNA, mRNA, and tRNA in organelles of fungi, plants, and protists; and mRNA of bacteria. subset: gosubset_prok synonym: "mRNA splicing" NARROW [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000374 name: Group III intron splicing namespace: biological_process def: "The splicing of Group III introns. This occurs by a ribozymic mechanism where the intron sequence forms a distinct 3D structure, characteristic of Group III introns, that is involved in catalyzing the splicing reactions, though protein factors are also required in vivo. Splicing occurs by a series of two transesterification reactions begun by a bulged adenosine residue within the intron sequence as the initiating nucleophile. The intron is excised as a lariat. Though very similar in structure and mechanism to Group II introns, Group III introns are smaller and more streamlined and the splice site consensus sequences are not as well conserved." [GOC:krc, PMID:11377794] comment: Note that Group III introns are known to be found in mRNA of plastids of euglenoid protists. subset: gosubset_prok synonym: "mRNA splicing" NARROW [] is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile [Term] id: GO:0000375 name: RNA splicing, via transesterification reactions namespace: biological_process alt_id: GO:0000385 alt_id: GO:0031202 def: "Splicing of RNA via a series of two transesterification reactions." [GOC:krc] comment: Note that nuclear mRNA, Group I, Group II, and Group III introns are all spliced by a series of two transesterification reactions that occur within the RNA itself, or between two RNAs in trans splicing. Some of these require one or more proteins to stabilize the catalytic conformation, while others are autocatalytic. Note that tRNA introns are spliced by a different catalytic mechanism. subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [GOC:krc, GOC:mah] synonym: "RNA splicing factor activity, transesterification mechanism" RELATED [GOC:krc, GOC:mah] synonym: "spliceosomal catalysis" RELATED [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000376 name: RNA splicing, via transesterification reactions with guanosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with exogenous guanosine as the initiating nucleophile." [GOC:krc, PMID:11377794] subset: gosubset_prok is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000377 name: RNA splicing, via transesterification reactions with bulged adenosine as nucleophile namespace: biological_process def: "Splicing of RNA via a series of two transesterification reactions with a bulged adenosine residue from the intron branch point as the initiating nucleophile. When the initial RNA for the splicing reaction is a single molecule (cis splicing), the excised intron is released in a lariat structure." [GOC:krc, PMID:11377794] subset: gosubset_prok synonym: "lariat RNA biosynthesis" RELATED [] synonym: "lariat RNA formation" RELATED [] is_a: GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000378 name: RNA exon ligation namespace: biological_process def: "The process of joining two exons, each of which has free ends that were generated by endonucleolytic cleavages, by a ligation reaction." [GOC:krc, ISBN:0879695897] comment: Note that this is not a part of spliceosomal RNA splicing. subset: gosubset_prok is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000379 name: tRNA-type intron splice site recognition and cleavage namespace: biological_process def: "The process by which the tertiary structure of a tRNA type intron is recognized, and the endonucleolytic cleavage of the RNA at both the 5' and 3' splice sites occurs." [GOC:krc, GOC:mah, ISBN:0879695897] subset: gosubset_prok is_a: GO:0006396 ! RNA processing relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation [Term] id: GO:0000380 name: alternative nuclear mRNA splicing, via spliceosome namespace: biological_process def: "The process of generating multiple mRNA molecules from a given set of exons by differential use of exons from the primary transcript(s) to form multiple mature mRNAs that vary in their exon composition." [GOC:krc, PMID:12110900] comment: Note that this process most commonly occurs in cis, selecting or skipping exons from the same primary transcript, but it has also been observed to occur in trans at low frequency, at least in some mammals. synonym: "splice site selection" BROAD [] is_a: GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000381 name: regulation of alternative nuclear mRNA splicing, via spliceosome namespace: biological_process def: "Any process that modulates the frequency, rate or extent of alternative splicing of nuclear mRNAs." [GOC:krc] synonym: "splice site selection" BROAD [] is_a: GO:0048024 ! regulation of nuclear mRNA splicing, via spliceosome intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome relationship: regulates GO:0000380 ! alternative nuclear mRNA splicing, via spliceosome [Term] id: GO:0000384 name: first spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the first transesterification reaction of spliceosomal mRNA splicing. The intron branch site adenosine is the nucleophile attacking the 5' splice site, resulting in cleavage at this position. In cis splicing, this is the step that forms a lariat structure of the intron RNA, while it is still joined to the 3' exon." [GOC:krc, ISBN:0879695897] synonym: "lariat formation, 5'-splice site cleavage" NARROW [] is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000386 name: second spliceosomal transesterification activity namespace: molecular_function def: "Catalysis of the second transesterification reaction of spliceosomal mRNA splicing. Ligation of the two exons occurs via a transesterification reaction where the free 3'-hydroxyl group of the 5' exon is the nucleophile attacking the 3' splice site. Non-expressed sequences are now detached from the exons. In cis splicing, the intron is in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "lariat formation, 5'-splice site cleavage" NARROW [] is_a: GO:0003824 ! catalytic activity relationship: part_of GO:0000375 ! RNA splicing, via transesterification reactions [Term] id: GO:0000387 name: spliceosomal snRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of one or more snRNA and multiple protein components to form a ribonucleoprotein complex that is involved in formation of the spliceosome." [GOC:krc, GOC:mah, ISBN:0879695897] synonym: "spliceosomal snRNP biogenesis" RELATED [GOC:mah] xref: Reactome:191763 "snRNP:Snurportin complex formation" xref: Reactome:191784 "snRNA Cap hypermethylation" xref: Reactome:191786 "snRNP complex assembly" xref: Reactome:191790 "Loading and methylation of Sm proteins onto SMN Complexes" xref: Reactome:191859 "snRNP Assembly" xref: Reactome:560676 "snRNA Cap hypermethylation" xref: Reactome:560677 "snRNP complex assembly" xref: Reactome:560697 "snRNP:Snurportin complex formation" xref: Reactome:563310 "snRNP Assembly" xref: Reactome:580473 "Loading and methylation of Sm proteins onto SMN Complexes" xref: Reactome:586415 "snRNA Cap hypermethylation" xref: Reactome:586416 "snRNP complex assembly" xref: Reactome:586433 "snRNP:Snurportin complex formation" xref: Reactome:588881 "snRNP Assembly" xref: Reactome:607444 "snRNA Cap hypermethylation" xref: Reactome:607445 "snRNP complex assembly" xref: Reactome:607457 "snRNP:Snurportin complex formation" xref: Reactome:609643 "snRNP Assembly" xref: Reactome:631935 "snRNA Cap hypermethylation" xref: Reactome:631936 "snRNP complex assembly" xref: Reactome:631940 "snRNP:Snurportin complex formation" xref: Reactome:634417 "snRNP Assembly" xref: Reactome:644515 "snRNA Cap hypermethylation" xref: Reactome:644516 "snRNP complex assembly" xref: Reactome:644520 "snRNP:Snurportin complex formation" xref: Reactome:645813 "snRNP Assembly" is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000388 name: spliceosome conformational change to release U4 (or U4atac) and U1 (or U11) namespace: biological_process alt_id: GO:0000396 alt_id: GO:0000397 def: "Rearrangement of the pre-catalytic spliceosome containing U4 (or U4atac) and U1 (or U11) snRNPs to unpair U4 (or U4atac) from U6 (or U6atac) and release it from the spliceosomal complex along with U1 (or U11)." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the A1 complex (yeast) or the B2 complex (mammalian). synonym: "3'-splice site cleavage, exon ligation" BROAD [] synonym: "spliceosomal A1 complex biosynthesis" NARROW [] synonym: "spliceosomal A1 complex formation" NARROW [] synonym: "spliceosomal B2 complex biosynthesis" NARROW [] synonym: "spliceosomal B2 complex formation" NARROW [] synonym: "U12-type spliceosome conformational change to release U4atac and U11" NARROW [] synonym: "U2-type spliceosome conformational change to release U4 and U1" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000393 ! spliceosomal conformational changes to generate catalytic conformation [Term] id: GO:0000389 name: nuclear mRNA 3'-splice site recognition namespace: biological_process alt_id: GO:0000382 alt_id: GO:0000383 def: "Recognition of the intron 3'-splice site by components of the assembling U2- or U12-type spliceosome." [GOC:krc, ISBN:0879695897] synonym: "U12-type nuclear mRNA 3'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 3'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection [Term] id: GO:0000390 name: spliceosome disassembly namespace: biological_process alt_id: GO:0000391 alt_id: GO:0000392 def: "Disassembly of the spliceosome with the ATP-dependent release of the product RNAs, one of which is composed of the joined exons. In cis splicing, the other product is the excised sequence, often a single intron, in a lariat structure." [GOC:krc, ISBN:0879695897] synonym: "spliceosome complex disassembly" EXACT [] synonym: "U12-type spliceosome disassembly" NARROW [] synonym: "U2-type spliceosome disassembly" NARROW [] is_a: GO:0032988 ! ribonucleoprotein complex disassembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000393 name: spliceosomal conformational changes to generate catalytic conformation namespace: biological_process def: "Structural rearrangements of the spliceosome complex, containing RNA to be spliced, to generate a catalytic conformation." [GOC:krc] synonym: "3'-splice site cleavage, exon ligation" BROAD [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000398 ! nuclear mRNA splicing, via spliceosome [Term] id: GO:0000394 name: RNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of RNA via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897] comment: Note that while typically associated with tRNA splicing, this mechanism of splicing is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "mRNA splicing" BROAD [] is_a: GO:0008380 ! RNA splicing [Term] id: GO:0000395 name: nuclear mRNA 5'-splice site recognition namespace: biological_process alt_id: GO:0000368 alt_id: GO:0000369 def: "Recognition of the intron 5'-splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] comment: Note that this step represents formation of the Commitment Complex (CC, in yeast) or the E complex (mammalian). synonym: "nuclear mRNA 5' splice site recognition" EXACT [] synonym: "spliceosomal CC complex biosynthesis" NARROW [] synonym: "spliceosomal CC complex formation" NARROW [] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] synonym: "U12-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U12-type nuclear mRNA 5'-splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5' splice site recognition" NARROW [] synonym: "U2-type nuclear mRNA 5'-splice site recognition" NARROW [] is_a: GO:0006376 ! mRNA splice site selection relationship: part_of GO:0045292 ! nuclear mRNA cis splicing, via spliceosome [Term] id: GO:0000398 name: nuclear mRNA splicing, via spliceosome namespace: biological_process alt_id: GO:0006374 alt_id: GO:0006375 def: "The joining together of exons from one or more primary transcripts of nuclear messenger RNA (mRNA) and the excision of intron sequences, via a spliceosomal mechanism, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0879695897] comment: Note that although the many U12-type introns have the sequence AT-AC at the intron termini, some introns with these terminal sequences are spliced by the U2-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. Note that although the majority of U2-type introns have the sequence GU-AG at the intron termini, some introns with these terminal sequences are spliced by the U12-type spliceosome. The distinguishing characteristics are sequences near the 5' splice site and the branch point sequences of the intron. synonym: "mRNA splicing" BROAD [] synonym: "nuclear mRNA splicing via U12-type spliceosome" NARROW [] synonym: "nuclear mRNA splicing via U2-type spliceosome" NARROW [] synonym: "pre-mRNA splicing" BROAD [] synonym: "splicing AT-AC intron" RELATED [] synonym: "splicing GT-AG intron" RELATED [] xref: Reactome:562935 "mRNA Splicing - Minor Pathway" xref: Reactome:563043 "mRNA Splicing - Major Pathway" xref: Reactome:588556 "mRNA Splicing - Minor Pathway" xref: Reactome:588662 "mRNA Splicing - Major Pathway" xref: Reactome:609297 "mRNA Splicing - Minor Pathway" xref: Reactome:609525 "mRNA Splicing - Major Pathway" xref: Reactome:633987 "mRNA Splicing - Minor Pathway" xref: Reactome:634096 "mRNA Splicing - Major Pathway" xref: Reactome:645547 "mRNA Splicing - Minor Pathway" xref: Reactome:645712 "mRNA Splicing - Major Pathway" xref: Reactome:655887 "mRNA Splicing - Minor Pathway" xref: Reactome:656042 "mRNA Splicing - Major Pathway" xref: Reactome:666851 "mRNA Splicing - Minor Pathway" xref: Reactome:672966 "mRNA Splicing - Minor Pathway" xref: Reactome:678685 "mRNA Splicing - Minor Pathway" xref: Reactome:689852 "mRNA Splicing - Minor Pathway" xref: Reactome:701588 "mRNA Splicing - Minor Pathway" xref: Reactome:701765 "mRNA Splicing - Major Pathway" xref: Reactome:716172 "mRNA Splicing - Minor Pathway" xref: Reactome:716341 "mRNA Splicing - Major Pathway" xref: Reactome:720746 "mRNA Splicing - Minor Pathway" xref: Reactome:72163 "mRNA Splicing - Major Pathway" xref: Reactome:72165 "mRNA Splicing - Minor Pathway" xref: Reactome:728122 "mRNA Splicing - Minor Pathway" xref: Reactome:731007 "mRNA Splicing - Minor Pathway" is_a: GO:0000377 ! RNA splicing, via transesterification reactions with bulged adenosine as nucleophile is_a: GO:0006397 ! mRNA processing [Term] id: GO:0000399 name: cellular bud neck septin structure namespace: cellular_component def: "Any of a series of septin structures that are localized in the bud neck of a budding fungal cell during the cell cycle." [GOC:krc] is_a: GO:0032155 ! cell division site part relationship: part_of GO:0005935 ! cellular bud neck [Term] id: GO:0000400 name: four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing four-way junctions, also known as Holliday junctions, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "forked DNA binding" BROAD [] synonym: "Holliday junction binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000401 name: open form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the open form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The open form of a four-way junction can be diagrammed without any of the strands crossing over." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "open form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000402 name: crossed form four-way junction DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing the crossed form of a four-way junction, also known as a Holliday junction, a structure where two DNA double strands are held together by reciprocal exchange of two of the four strands, one strand each from the two original helices. The crossed form of a four-way junction cannot be diagrammed without any of the strands crossing over, and instead contains a single crossover between two of the strands." [GOC:krc, ISBN:0815332181, PMID:15563464] synonym: "crossed form Holliday junction binding" EXACT [] is_a: GO:0000400 ! four-way junction DNA binding [Term] id: GO:0000403 name: Y-form DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with segment of DNA shaped like a Y. This shape occurs when DNA contains a region of paired double-stranded DNA on one end and a region of unpaired DNA strands on the opposite end." [GOC:elh, PMID:16781730] synonym: "forked DNA binding" BROAD [] synonym: "splayed Y-form DNA binding" EXACT [] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000404 name: loop DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA containing a loop. A loop occurs when DNA contains a large insertion or deletion that causes a region of unpaired single-stranded DNA to loop out, while the rest of the DNA is in a paired double-stranded configuration." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding is_a: GO:0032135 ! DNA insertion or deletion binding [Term] id: GO:0000405 name: bubble DNA binding namespace: molecular_function def: "Interacting selective with DNA that contains a bubble. A bubble occurs when DNA contains a region of unpaired, single-stranded DNA flanked on both sides by regions of paired, double-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000406 name: double-strand/single-strand DNA junction binding namespace: molecular_function def: "Interacting selectively and non-covalently with a region of DNA that contains double-stranded DNA flanked by a region of single-stranded DNA." [GOC:elh, PMID:16781730] is_a: GO:0000217 ! DNA secondary structure binding [Term] id: GO:0000407 name: pre-autophagosomal structure namespace: cellular_component def: "A punctate structure localized in the vicinity of the vacuole that is required for the formation of autophagosomes." [GOC:elh, PMID:11689437, PMID:12048214, PMID:12554655] synonym: "isolation membrane" RELATED [] synonym: "PAS" EXACT [] synonym: "perivacuolar space" NARROW [] synonym: "phagophore assembly site" RELATED [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000408 name: EKC/KEOPS protein complex namespace: cellular_component def: "A protein complex proposed to be involved in transcription as well as promoting telomere uncapping and telomere elongation. For example, in Saccharomyces cerevisiae the complex contains Bud32p, Kae1p, Gon7p, Cgi121p, and Pcc1p." [GOC:elh, PMID:16564010, PMID:16874308] synonym: "Endopeptidase-like Kinase Chromatin-associated protein complex" EXACT [] synonym: "Kinase, putative Endopeptidase and Other Proteins of Small size protein complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000409 name: regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent or transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0045990 ! regulation of transcription by carbon catabolites [Term] id: GO:0000410 name: negative regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription." [GOC:mah] synonym: "down regulation of transcription by galactose" EXACT [] synonym: "down-regulation of transcription by galactose" EXACT [] synonym: "downregulation of transcription by galactose" EXACT [] synonym: "inhibition of transcription by galactose" NARROW [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045013 ! negative regulation of transcription by carbon catabolites [Term] id: GO:0000411 name: positive regulation of transcription by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription." [GOC:go_curators] synonym: "activation of transcription by galactose" NARROW [] synonym: "stimulation of transcription by galactose" NARROW [] synonym: "up regulation of transcription by galactose" EXACT [] synonym: "up-regulation of transcription by galactose" EXACT [] synonym: "upregulation of transcription by galactose" EXACT [] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0045991 ! positive regulation of transcription by carbon catabolites [Term] id: GO:0000412 name: histone peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a histone by cis-trans isomerization of a proline residue." [GOC:krc] synonym: "histone proline isomerization" EXACT [] is_a: GO:0000413 ! protein peptidyl-prolyl isomerization is_a: GO:0016570 ! histone modification [Term] id: GO:0000413 name: protein peptidyl-prolyl isomerization namespace: biological_process def: "The modification of a protein by cis-trans isomerization of a proline residue." [GOC:krc, PMID:16959570] synonym: "protein proline isomerization" EXACT [] is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0000414 name: regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] is_a: GO:0031060 ! regulation of histone methylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010452 ! histone H3-K36 methylation relationship: regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000415 name: negative regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "down regulation of histone H3-K36 methylation" EXACT [] synonym: "down-regulation of histone H3-K36 methylation" EXACT [] synonym: "downregulation of histone H3-K36 methylation" EXACT [] synonym: "inhibition of histone H3-K36 methylation" NARROW [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031061 ! negative regulation of histone methylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010452 ! histone H3-K36 methylation relationship: negatively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000416 name: positive regulation of histone H3-K36 methylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the covalent addition of a methyl group to the lysine at position 36 of histone H3." [GOC:krc] synonym: "activation of histone H3-K36 methylation" NARROW [] synonym: "stimulation of histone H3-K36 methylation" NARROW [] synonym: "up regulation of histone H3-K36 methylation" EXACT [] synonym: "up-regulation of histone H3-K36 methylation" EXACT [] synonym: "upregulation of histone H3-K36 methylation" EXACT [] is_a: GO:0000414 ! regulation of histone H3-K36 methylation is_a: GO:0031062 ! positive regulation of histone methylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010452 ! histone H3-K36 methylation relationship: positively_regulates GO:0010452 ! histone H3-K36 methylation [Term] id: GO:0000417 name: HIR complex namespace: cellular_component def: "A protein complex proposed to be involved in replication-independent nucleosome assembly, by promoting histone deposition onto DNA. For example, in Saccharomyces, the complex contains Hir1p, Hir2p, Hir3p, and Hpc2p." [GOC:elh, GOC:mah, PMID:16303565, PMID:17180700] is_a: GO:0005678 ! chromatin assembly complex [Term] id: GO:0000418 name: DNA-directed RNA polymerase IV complex namespace: cellular_component def: "RNA polymerase IV is a multisubunit RNA polymerase complex found in the nucleus of plants. In addition to RNA polymerases I, II, and III, the essential RNA polymerases present in all eukaryotes, plants have two additional nuclear RNA polymerases, Pol IV and Pol V, that play nonredundant roles in siRNA-directed DNA methylation and gene silencing. Pol IV is required for siRNA production and Pol V is required for generating noncoding transcripts at target loci. Pol IV is composed of subunits that are paralogous or identical to the 12 subunits of Pol II. The largest and second-largest subunits of Pol IV are the catalytic subunits and share similarity with the corresponding subunits of other eukaryotic and bacterial multisubunit RNA polymerases." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984, PMID:19110459] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0000419 name: DNA-directed RNA polymerase IVb complex namespace: cellular_component def: "RNA polymerase IVb is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVa, while the largest subunit is found only in the IVa complex and contains an extended C-terminal domain (CTD) that includes multiple repeats of a 16 amino-acid consensus sequence as well as other sequences. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:16140984] is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex [Term] id: GO:0000420 name: DNA-directed RNA polymerase IVa complex namespace: cellular_component def: "RNA polymerase IVa is a multisubunit RNA polymerase complex found in the nucleus of plants and involved in accumulation of siRNAs and in DNA methylation-dependent silencing of endogenous repeated sequences. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The second largest subunit is also found in RNA polymerase IVb, while the largest subunit is found only in the IVa complex. The remainder of the complex is composed of smaller subunits." [GOC:krc, GOC:mtg_sensu, PMID:15692015, PMID:15766525, PMID:16140984] is_a: GO:0000418 ! DNA-directed RNA polymerase IV complex [Term] id: GO:0000421 name: autophagic vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding an autophagic vacuole, a double-membrane-bounded vesicle in which endogenous cellular material is sequestered." [GOC:isa_complete] synonym: "autophagosome membrane" EXACT [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005776 ! autophagic vacuole [Term] id: GO:0000422 name: mitochondrion degradation namespace: biological_process def: "The process by which mitochondria are delivered to the vacuole and degraded in response to changing cellular conditions, autophagy of mitochondria." [PMID:15798367] synonym: "mitophagy" EXACT [] xref: Wikipedia:Autophagy_(cellular)#Selective_autophagy xref: Wikipedia:Mitophagy is_a: GO:0006914 ! autophagy [Term] id: GO:0000423 name: macromitophagy namespace: biological_process def: "Degradation of a mitochondrion by macroautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016236 ! macroautophagy [Term] id: GO:0000424 name: micromitophagy namespace: biological_process def: "Degradation of a mitochondrion by microautophagy." [PMID:15798367] is_a: GO:0000422 ! mitochondrion degradation is_a: GO:0016237 ! microautophagy [Term] id: GO:0000425 name: macropexophagy namespace: biological_process def: "Degradation of a peroxisome by macropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016236 ! macroautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000426 name: micropexophagy namespace: biological_process def: "Degradation of a peroxisome by micropexophagy." [PMID:12914914, PMID:16973210] is_a: GO:0016237 ! microautophagy is_a: GO:0030242 ! peroxisome degradation [Term] id: GO:0000427 name: plastid-encoded plastid RNA polymerase complex namespace: cellular_component def: "An RNA polymerase complex containing polypeptides encoded by the plastid genome. Plastid-encoded DNA-directed RNA polymerases resemble eubacterial multisubunit RNA polymerases, with a core composed of alpha, beta, and beta-prime subunits. Some forms contain multiple additional subunits. An additional sigma factor subunit is required for promoter recognition." [GOC:krc, GOC:mah, GOC:pj] is_a: GO:0000428 ! DNA-directed RNA polymerase complex is_a: GO:0044435 ! plastid part intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0009536 ! plastid [Term] id: GO:0000428 name: DNA-directed RNA polymerase complex namespace: cellular_component def: "A protein complex that possesses DNA-directed RNA polymerase activity." [GOC:krc] is_a: GO:0030880 ! RNA polymerase complex [Term] id: GO:0000429 name: regulation of transcription from RNA polymerase II promoter by carbon catabolites namespace: biological_process def: "Any process involving carbon catabolites that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter is_a: GO:0045990 ! regulation of transcription by carbon catabolites [Term] id: GO:0000430 name: regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites is_a: GO:0046015 ! regulation of transcription by glucose [Term] id: GO:0000431 name: regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] is_a: GO:0000409 ! regulation of transcription by galactose is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites [Term] id: GO:0000432 name: positive regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by glucose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites is_a: GO:0046016 ! positive regulation of transcription by glucose [Term] id: GO:0000433 name: negative regulation of transcription from RNA polymerase II promoter by glucose namespace: biological_process def: "Any process involving glucose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by glucose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by glucose" NARROW [] is_a: GO:0000430 ! regulation of transcription from RNA polymerase II promoter by glucose is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites is_a: GO:0045014 ! negative regulation of transcription by glucose [Term] id: GO:0000434 name: negative regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that stops, prevents or reduces the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by galactose" NARROW [] is_a: GO:0000410 ! negative regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000437 ! negative regulation of transcription from RNA polymerase II promoter by carbon catabolites [Term] id: GO:0000435 name: positive regulation of transcription from RNA polymerase II promoter by galactose namespace: biological_process def: "Any process involving galactose that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by galactose" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by galactose" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by galactose" EXACT [] is_a: GO:0000411 ! positive regulation of transcription by galactose is_a: GO:0000431 ! regulation of transcription from RNA polymerase II promoter by galactose is_a: GO:0000436 ! positive regulation of transcription from RNA polymerase II promoter by carbon catabolites [Term] id: GO:0000436 name: positive regulation of transcription from RNA polymerase II promoter by carbon catabolites namespace: biological_process def: "Any process involving carbon catabolites that activates or increases the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "activation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] synonym: "stimulation of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter [Term] id: GO:0000437 name: negative regulation of transcription from RNA polymerase II promoter by carbon catabolites namespace: biological_process def: "Any process involving carbon catabolites that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:krc] synonym: "down regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter by carbon catabolites" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter by carbon catabolites" NARROW [] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0000429 ! regulation of transcription from RNA polymerase II promoter by carbon catabolites [Term] id: GO:0000438 name: core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The core TFIIH complex when it is part of the general transcription factor TFIIH. In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex is_a: GO:0044451 ! nucleoplasm part intersection_of: GO:0000439 ! core TFIIH complex intersection_of: part_of GO:0005675 ! holo TFIIH complex relationship: part_of GO:0000443 ! SSL2-core TFIIH complex portion of holo TFIIH complex [Term] id: GO:0000439 name: core TFIIH complex namespace: cellular_component def: "The 5 subunit core of TFIIH that has tightly associated subunits and is found in both the general transcription factor holo-TFIIH and in the nucleotide-excision repair factor 3 complex. In S. cerevisiae, it is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4. In humans, it is composed of XPD, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex relationship: part_of GO:0000441 ! SSL2-core TFIIH complex [Term] id: GO:0000440 name: core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). In S. cerevisiae, it is composed of Rad3p, Tfb1p, Tfb2p, Ssl1p, and Tfb4p. In humans, it is composed of ERCC2, p62, p55, p44, p34." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000439 ! core TFIIH complex intersection_of: GO:0000439 ! core TFIIH complex intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex relationship: part_of GO:0000442 ! SSL2-core TFIIH complex portion of NEF3 complex [Term] id: GO:0000441 name: SSL2-core TFIIH complex namespace: cellular_component def: "A complex which is part of both the general transcription factor TFIIH and the nucleotide-excision repair factor 3 complex. It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, more loosely associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] subset: goslim_pir is_a: GO:0043234 ! protein complex [Term] id: GO:0000442 name: SSL2-core TFIIH complex portion of NEF3 complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the nucleotide-excision repair factor 3 (NEF3). It is composed of the tightly associated 5 subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044428 ! nuclear part intersection_of: GO:0000441 ! SSL2-core TFIIH complex intersection_of: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex relationship: part_of GO:0000112 ! nucleotide-excision repair factor 3 complex [Term] id: GO:0000443 name: SSL2-core TFIIH complex portion of holo TFIIH complex namespace: cellular_component def: "The SSL2-core TFIIH complex when it is part of the general transcription factor TFIIH. It is composed of the tightly associated five subunit core TFIIH subcomplex plus one additional, less tighly associated subunit. The subunits are well conserved from yeast to humans. In S. cerevisiae, the 5-subunit core is composed of Rad3, Tfb1, Tfb2, Ssl1, Tfb4 and the loosely associated subunit is Ssl2p (also called Rad25). In humans, the 5 subunit core is composed of ERCC2, p62, p55, p44, p34 and the loosely associated subunit is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0000441 ! SSL2-core TFIIH complex is_a: GO:0044451 ! nucleoplasm part relationship: part_of GO:0005675 ! holo TFIIH complex [Term] id: GO:0000444 name: MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore. It helps to recruit outer kinetochore subunits that will bind to microtubules. In humans, it consists of MIS12, DSN1, NSL1 and PMF1." [GOC:krc, PMID:14633972, PMID:16585270] synonym: "Mis12 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000445 name: THO complex part of transcription export complex namespace: cellular_component def: "The THO complex when it is part of the TREX (TRanscription EXport) complex that is involved in coupling transcription to export of mRNAs to the cytoplasm. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] synonym: "THO complex part of TREX complex" EXACT [] is_a: GO:0000347 ! THO complex intersection_of: GO:0000347 ! THO complex intersection_of: part_of GO:0000346 ! transcription export complex relationship: part_of GO:0000346 ! transcription export complex [Term] id: GO:0000446 name: nucleoplasmic THO complex namespace: cellular_component def: "The THO complex when it is acting as a nuclear complex that is required for transcription elongation through genes containing tandemly repeated DNA sequences. In S. cerevisiae, it is composed of four subunits: Hpr1, Tho2, Thp1, and Mft1, while the human complex is composed of 7 subunits." [GOC:krc, PMID:11060033, PMID:11979277, PMID:16983072] is_a: GO:0000347 ! THO complex is_a: GO:0008023 ! transcription elongation factor complex [Term] id: GO:0000447 name: endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A2" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000448 name: cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process alt_id: GO:0000490 def: "Endonucleolytic cleavage within ITS2 between the 5.8S rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "cleavage at C2" RELATED [] synonym: "cleavage in ITS2 of tricistronic rRNA transcript to separate 5.8S and LSU rRNAs (SSU-rRNA, 5.8S rRNA, LSU-rRNA)" EXACT [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000449 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. For example, primary ribosomal RNA transcripts containing three genes, in this order, are produced in E. coli and other prokaryotic species. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000450 name: cleavage of bicistronic rRNA transcript (SSU-rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of pre-rRNAs originally produced as a bicistronic rRNA transcript that contains the SSU-rRNA and the LSU-rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with two genes in this order are produced in Archaeal species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000451 name: rRNA 2'-O-methylation namespace: biological_process def: "The addition of a methyl group to the 2'-oxygen atom of a nucleotide residue in an rRNA molecule during ribosome biogenesis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031167 ! rRNA methylation [Term] id: GO:0000452 name: snoRNA guided rRNA 2'-O-methylation namespace: biological_process def: "The posttranscriptional addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of methylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] synonym: "snoRNA guided rRNA 2'-O-ribose methylation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000453 name: enzyme-directed rRNA 2'-O-methylation namespace: biological_process def: "The addition of methyl groups to the 2'-oxygen atom of nucleotide residues in an rRNA molecule during ribosome biogenesis where the methylase specifies the site that becomes methylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0000451 ! rRNA 2'-O-methylation [Term] id: GO:0000454 name: snoRNA guided rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine in an rRNA molecule during ribosome biogenesis using a snoRNA guide that targets the position of pseudouridylation." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000455 name: enzyme-directed rRNA pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine during ribosome biogenesis where the enzyme specifies the site that becomes pseudouridylated without using a guide RNA." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031118 ! rRNA pseudouridine synthesis [Term] id: GO:0000456 name: dimethylation involved in SSU-rRNA maturation namespace: biological_process def: "Dimethylation of the N6 amino groups of two consecutive adenosine residues near the 3'-end of the SSU rRNA. This process has been conserved from bacteria to eukaryotes." [GOC:curators, GOC:dph, GOC:tb, ISBN:1555811337 "Modification and Editing of RNA"] is_a: GO:0031167 ! rRNA methylation relationship: part_of GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000457 name: endonucleolytic cleavage between SSU-rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-SSU-rRNA from a pre-LSU-rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) relationship: part_of GO:0002109 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000458 name: endonucleolytic cleavage between LSU-rRNA and 5S rRNA of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) namespace: biological_process def: "Endonucleolytic cleavage to separate a pre-LSU-rRNA from a pre-5S rRNA originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the Large Subunit (LSU) rRNA, and the 5S rRNA, in that order, from 5' to 3' along the primary transcript. Note that the use of the word tricistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000449 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 5S) relationship: part_of GO:0002108 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) [Term] id: GO:0000459 name: exonucleolytic trimming involved in rRNA processing namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule in the process to generate a mature rRNA molecule." [GOC:curators] synonym: "exonucleolytic trimming during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing [Term] id: GO:0000460 name: maturation of 5.8S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000461 name: endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage at the 3'-end of the SSU-rRNA from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at site D" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000462 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000463 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000464 name: endonucleolytic cleavage in ITS1 upstream of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within Internal Transcribed Spacer 1 (ITS1) upstream of the 5.8S rRNA derived from an originally tricistronic rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, this endonucleolytic cleavage within ITS1 initiates the maturation of the LSU and the 5.8S rRNAs." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage at A3" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000465 name: exonucleolytic trimming to generate mature 5'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 5'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000466 name: maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of an rRNA molecule originally produced as part of a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000467 name: exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Exonucleolytic digestion of a pre-rRNA molecule to generate the mature 3'-end of a 5.8S rRNA molecule derived from an originally tricistronic pre-rRNA transcript that contained the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] is_a: GO:0000459 ! exonucleolytic trimming involved in rRNA processing is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000466 ! maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000468 name: generation of mature 3'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in generating the mature 3'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:krc, PMID:10690410] synonym: "processing at B2" NARROW [] is_a: GO:0031125 ! rRNA 3'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000469 name: cleavage involved in rRNA processing namespace: biological_process def: "Any cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule." [GOC:curators] synonym: "cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0006364 ! rRNA processing [Term] id: GO:0000470 name: maturation of LSU-rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000471 name: endonucleolytic cleavage in 3'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 3'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. In S. cerevisiae, endonucleolytic cleavage within the 3'-ETS of the pre-RNA, which may occur cotranscriptionally, is the first step in rRNA processing, and initiates a cascade of subsequent processing and modification events." [GOC:krc, PMID:10690410] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000472 name: endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5'-External Transcribed Spacer (5'-ETS) and the 5' end of the SSU-rRNA of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript, to produce the mature end of the SSU-rRNA." [GOC:curators, PMID:10690410] synonym: "endonucleolytic cleavage at A1" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000473 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000474 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, 5.8 S rRNA, 2S rRNA, and Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000475 name: maturation of 2S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 2S ribosomal RNA (rRNA) molecule into a mature 2S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000476 name: maturation of 4.5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 4.5S ribosomal RNA (rRNA) molecule into a mature 4.5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000477 name: generation of mature 5'-end of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Cleavage within ITS2 to generate the mature 5'-end of an LSU-rRNA derived from a tricistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:10690410] synonym: "processing at C1" NARROW [] is_a: GO:0000469 ! cleavage involved in rRNA processing is_a: GO:0000967 ! rRNA 5'-end processing relationship: part_of GO:0000463 ! maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000478 name: endonucleolytic cleavage involved in rRNA processing namespace: biological_process def: "Any endonucleolytic cleavage involved in the conversion of a primary ribosomal RNA (rRNA) transcript into a mature rRNA molecule. Some endonucleolytic cleavages produce the mature end, while others are a step in the process of generating the mature end from the pre-rRNA." [GOC:krc, PMID:10690410] synonym: "endonucleolytic cleavage during rRNA processing" RELATED [GOC:dph, GOC:tb] is_a: GO:0000469 ! cleavage involved in rRNA processing [Term] id: GO:0000479 name: endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with three genes, in this order, are produced in the nuclei of many eukaryotic species, including S. cerevisiae." [GOC:curators, PMID:10690410] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000480 name: endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage within the 5'-External Transcribed Spacer (ETS) of a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 5.8S rRNA, and the Large Subunit (LSU) rRNA in that order from 5' to 3' along the primary transcript. Endonucleolytic cleavage within the 5'-ETS of the pre-RNA is conserved as one of the early steps of rRNA processing in all eukaryotes, but the specific position of cleavage is variable." [GOC:curators, PMID:10690410, PMID:15282326] synonym: "endonucleolytic cleavage at A-prime" NARROW [PMID:15282326] synonym: "endonucleolytic cleavage at A0" NARROW [] is_a: GO:0000479 ! endonucleolytic cleavage of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) relationship: part_of GO:0000462 ! maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) [Term] id: GO:0000481 name: maturation of 5S rRNA namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule." [GOC:curators] is_a: GO:0006364 ! rRNA processing [Term] id: GO:0000482 name: maturation of 5S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5S ribosomal RNA (rRNA) molecule into a mature 5S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000481 ! maturation of 5S rRNA [Term] id: GO:0000483 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the nuclei of D. melanogaster as well as in those of other dipteran species." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0000484 name: cleavage between SSU-rRNA and 5.8S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the SSU-rRNA and the 5.8S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000474 ! maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000485 name: cleavage between 2S rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000473 ! maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA [Term] id: GO:0000486 name: cleavage between 5.8S rRNA and 2S rRNA of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5.8S rRNA and the 2S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contained the Small SubUnit (SSU) rRNA, the 5.8S rRNA, 2S rRNA, and the Large SubUnit (LSU) rRNA, in that order, from 5' to 3' along the primary transcript." [GOC:curators, PMID:768488] is_a: GO:0000483 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) relationship: part_of GO:0000475 ! maturation of 2S rRNA relationship: part_of GO:0000487 ! maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) [Term] id: GO:0000487 name: maturation of 5.8S rRNA from tetracistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, 2S rRNA, LSU-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor 5.8S ribosomal RNA (rRNA) molecule into a mature 5.8S rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, the 8.8S rRNA, the 2S rRNA, and the Large Subunit (LSU) in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000460 ! maturation of 5.8S rRNA [Term] id: GO:0000488 name: maturation of LSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0000489 name: maturation of SSU-rRNA from tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0000491 name: small nucleolar ribonucleoprotein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a snoRNA to form a small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "snoRNP assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly [Term] id: GO:0000492 name: box C/D snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box C/D snoRNA to form a box C/D small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc] synonym: "box C/D small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000493 name: box H/ACA snoRNP assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins and a box H/ACA snoRNA to form a box H/ACA small nucleolar ribonucleoprotein (snoRNP) complex." [GOC:krc, PMID:12515383] synonym: "box H/ACA small nucleolar ribonucleoprotein complex assembly" EXACT [] is_a: GO:0000491 ! small nucleolar ribonucleoprotein complex assembly [Term] id: GO:0000494 name: box C/D snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box C/D snoRNA molecule." [GOC:krc] synonym: "box C/D snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034963 ! box C/D snoRNA processing [Term] id: GO:0000495 name: box H/ACA snoRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a box H/ACA snoRNA molecule." [GOC:krc] synonym: "box H/ACA snoRNA 3' end processing" EXACT [] is_a: GO:0031126 ! snoRNA 3'-end processing is_a: GO:0034964 ! box H/ACA snoRNA processing [Term] id: GO:0000496 name: base pairing namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target nucleic acid molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other nucleic acid molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. xref: Wikipedia:Base_pair is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0000497 name: base pairing with DNA namespace: molecular_function def: "Interacting selectively and non-covalently with nucleic acid via hydrogen bonds between the bases of a gene product molecule and the bases of a target DNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with DNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003677 ! DNA binding [Term] id: GO:0000498 name: base pairing with RNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribonucleic acid (RNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target RNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000496 ! base pairing is_a: GO:0003723 ! RNA binding [Term] id: GO:0000499 name: base pairing with mRNA namespace: molecular_function def: "Interacting selectively and non-covalently with messenger ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target mRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000500 name: RNA polymerase I upstream activating factor complex namespace: cellular_component def: "A complex required for the transcription of rDNA by RNA polymerase I. In yeast the complex consists of Rrrn5p, Rrn9p, Rrn10p, histones H3 and H4, and Uaf30p." [PMID:11500378] synonym: "RNA polymerase I upstream activation factor complex" EXACT [] synonym: "UAF" EXACT [] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0000501 name: flocculation via cell wall protein-carbohydrate interaction namespace: biological_process def: "Mannose-sensitive, nonsexual aggregation of cells mediated by protein-carbohydrate (flocculin-mannan) interaction present in the cell wall. This process is pH- and calcium-dependent and reversible. An example of this process is found in Saccharomyces cerevisiae." [DOI:10.1016/S0963-9969(99)00021-6, GOC:sgd_curators] subset: gosubset_prok is_a: GO:0000128 ! flocculation [Term] id: GO:0000502 name: proteasome complex namespace: cellular_component def: "A large multisubunit complex which catalyzes protein degradation. This complex consists of the barrel shaped proteasome core complex and one or two associated proteins or complexes that act in regulating entry into or exit from the core." [GOC:rb] subset: goslim_pir synonym: "26S proteasome" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0000504 name: proteasome regulatory particle (sensu Bacteria) namespace: cellular_component def: "OBSOLETE. A multisubunit complex that recognizes and unfolds ubiquitinated proteins, and translocates them to the core complex in an ATP dependent manner. As in, but not restricted to, the taxon Bacteria (Bacteria, ncbi_taxonomy_id:2)." [GOC:rb] comment: This term was made obsolete because there is no ubiquitin in bacteria and they do not have proteasome regulatory particles. Instead they have proteasome-activating nucleotidase. synonym: "26S proteasome" NARROW [] is_obsolete: true [Term] id: GO:0000506 name: glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI anchors for cell surface proteins. The complex contains PIG-A, PIG-C, PIG-H, PIG-Q, PIG-P, and DPM2 in human, and Eri1p, Gpi1p, Gpi2p, Gpi15p, Gpi19p, and Spt14p in budding yeast." [GOC:kp, GOC:rb, PMID:10944123, PMID:15163411] comment: Note that this term should not be confused with 'GPI-anchor transamidase complex ; GO:0042765', which represents a distinct complex with a different catalytic activity. synonym: "GPI-GlcNAc transferase complex" EXACT [] synonym: "GPI-GnT complex" EXACT [] synonym: "GPI-N-acetylglucosaminyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044432 ! endoplasmic reticulum part [Term] id: GO:0000578 name: embryonic axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or a point in an embryo." [GOC:dph, GOC:go_curators, GOC:sdb_2009, GOC:tb] synonym: "embryonic axis determination" RELATED [] is_a: GO:0009798 ! axis specification is_a: GO:0009880 ! embryonic pattern specification [Term] id: GO:0000700 name: mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of single bases present in mismatches by the cleavage the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000701 name: purine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of purines present in mismatches, especially opposite oxidized purines, by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [GOC:elh, PMID:9224623] synonym: "A/G-specific adenine DNA glycosylase activity" NARROW [] xref: EC:3.2.2.- is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0000702 name: oxidized base lesion DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of oxidized bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site." [GOC:elh, PMID:11554296] subset: gosubset_prok is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000703 name: oxidized pyrimidine base lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0019004 def: "Catalysis of the removal oxidized pyrimidine bases by cleaving the N-C1' glycosidic bond between the oxidized pyrimidine and the deoxyribose sugar. The reaction involves formation of a covalent enzyme-pyrimidine base intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. subset: gosubset_prok synonym: "bifunctional DNA glycosylase" BROAD [] synonym: "DNA glycosylase/AP-lyase" BROAD [] synonym: "DNA glycosylase/beta-lyase" BROAD [] synonym: "endodeoxyribonuclease III" RELATED [] synonym: "endonuclease III" RELATED [] synonym: "endonuclease VIII activity" RELATED [] synonym: "pyrimidine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: Reactome:25087 "oxidized pyrimidine base lesion DNA N-glycosylase activity" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: GO:0000704 name: pyrimidine dimer DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of pyrimidine dimers by removing the 5' pyrimidine of the dimer by cleaving the N-C1' glycosidic bond between the 5' pyrimidine of the dimer and the deoxyribose sugar. The reaction releases the 5' pyrimidine of the dimer and leaves an apurinic (AP) site. The reaction involves the formation of a covalent enzyme substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apyrimidinic (AP) site." [GOC:elh, PMID:9224623] is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity is_a: GO:0004520 ! endodeoxyribonuclease activity is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0000705 name: achiasmate meiosis I namespace: biological_process def: "The first division of meiosis in which homologous chromosomes are paired and segregated from each other, occurring in the constitutive absence of chiasmata." [GOC:elh, GOC:sart, PMID:10690419] is_a: GO:0007127 ! meiosis I [Term] id: GO:0000706 name: meiotic DNA double-strand break processing namespace: biological_process def: "The cell cycle process whereby the 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang occurs. This takes place during meiosis." [GOC:elh, PMID:9334324] is_a: GO:0000729 ! DNA double-strand break processing is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0000707 name: meiotic DNA recombinase assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form higher order oligomers on single-stranded DNA." [GOC:elh, PMID:11459983] is_a: GO:0000730 ! DNA recombinase assembly is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000708 name: meiotic strand invasion namespace: biological_process def: "The cell cycle process whereby the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules. This occurs during meiosis." [GOC:elh, PMID:10915877] synonym: "meiotic D-loop biosynthesis" RELATED [] synonym: "meiotic D-loop formation" RELATED [] is_a: GO:0022402 ! cell cycle process is_a: GO:0042148 ! strand invasion relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000709 name: meiotic joint molecule formation namespace: biological_process def: "The conversion of the paired broken DNA and homologous duplex DNA into a four-stranded branched intermediate, known as a joint molecule, formed during meiotic recombination. These joint molecules contain Holliday junctions on either side of heteroduplex DNA." [GOC:elh, PMID:8521495] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000710 name: meiotic mismatch repair namespace: biological_process def: "A system for the identification and correction of base-base mismatches, small insertion-deletion loops, and regions of heterology that are present in duplex DNA formed with strands from two recombining molecules. Correction of the mismatch can result in non-Mendelian segregation of alleles following meiosis." [GOC:elh, PMID:10357855] is_a: GO:0006298 ! mismatch repair is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000711 name: meiotic DNA repair synthesis namespace: biological_process def: "During meiosis, the synthesis of DNA proceeding from the broken 3' single-strand DNA end that uses the homologous intact duplex as the template." [GOC:elh, PMID:9334324] is_a: GO:0000731 ! DNA synthesis involved in DNA repair is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000712 name: resolution of meiotic recombination intermediates namespace: biological_process def: "The cleavage and rejoining of intermediates, such as Holliday junctions, formed during meiotic recombination to produce two intact molecules in which genetic material has been exchanged." [GOC:elh, PMID:11733053] synonym: "crossover biosynthesis" NARROW [] synonym: "crossover formation" NARROW [] synonym: "formation of chiasmata" NARROW [] synonym: "homologous chromosome separation at meiosis I" EXACT [] synonym: "meiotic homologous chromosome separation" RELATED [] synonym: "resolution of meiotic joint molecules as recombinants" NARROW [GOC:elh, GOC:mah] is_a: GO:0051307 ! meiotic chromosome separation relationship: part_of GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0000713 name: meiotic heteroduplex formation namespace: biological_process def: "During meiosis, the formation of a stable duplex DNA that contains one strand from each of the two recombining DNA molecules." [GOC:elh, PMID:9334324] is_a: GO:0022402 ! cell cycle process is_a: GO:0030491 ! heteroduplex formation relationship: part_of GO:0006310 ! DNA recombination relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000714 name: meiotic strand displacement namespace: biological_process def: "The cell cycle process whereby the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA is rejected. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules. This occurs during meiosis." [GOC:elh, PMID:10357855] is_a: GO:0000732 ! strand displacement is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0000715 name: nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions in DNA, such as pyrimidine-dimers, intrastrand cross-links, and bulky adducts. The wide range of substrate specificity suggests the repair complex recognizes distortions in the DNA helix." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW [] xref: Reactome:563401 "DNA Damage Recognition in GG-NER" xref: Reactome:589020 "DNA Damage Recognition in GG-NER" xref: Reactome:609745 "DNA Damage Recognition in GG-NER" xref: Reactome:634442 "DNA Damage Recognition in GG-NER" xref: Reactome:645905 "DNA Damage Recognition in GG-NER" xref: Reactome:656223 "DNA Damage Recognition in GG-NER" xref: Reactome:661351 "DNA Damage Recognition in GG-NER" xref: Reactome:667137 "DNA Damage Recognition in GG-NER" xref: Reactome:673279 "DNA Damage Recognition in GG-NER" xref: Reactome:678960 "DNA Damage Recognition in GG-NER" xref: Reactome:683889 "DNA Damage Recognition in GG-NER" xref: Reactome:690141 "DNA Damage Recognition in GG-NER" xref: Reactome:701890 "DNA Damage Recognition in GG-NER" xref: Reactome:716462 "DNA Damage Recognition in GG-NER" xref: Reactome:728425 "DNA Damage Recognition in GG-NER" xref: Reactome:73940 "DNA Damage Recognition in GG-NER" is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000716 name: transcription-coupled nucleotide-excision repair, DNA damage recognition namespace: biological_process def: "The identification of lesions on the actively transcribed strand of the DNA duplex as well as a small subset of lesions not recognized by the general nucleotide-excision repair pathway." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "pyrimidine-dimer repair, DNA damage recognition" NARROW [] xref: Reactome:109972 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:560216 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:585981 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:607083 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:631491 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:644253 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:654718 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:660508 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:666281 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:672323 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:678123 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:683050 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:689178 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:700482 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:714988 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:720348 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:727442 "RNA Pol II is blocked by the lesion leading to reduced transcription" xref: Reactome:730627 "RNA Pol II is blocked by the lesion leading to reduced transcription" is_a: GO:0000715 ! nucleotide-excision repair, DNA damage recognition relationship: part_of GO:0006283 ! transcription-coupled nucleotide-excision repair [Term] id: GO:0000717 name: nucleotide-excision repair, DNA duplex unwinding namespace: biological_process def: "The unwinding, or local denaturation, of the DNA duplex to create a bubble around the site of the DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:550670 "Formation of open bubble structure in DNA by helicases" xref: Reactome:577323 "Formation of open bubble structure in DNA by helicases" xref: Reactome:600224 "Formation of open bubble structure in DNA by helicases" xref: Reactome:623730 "Formation of open bubble structure in DNA by helicases" xref: Reactome:640794 "Formation of open bubble structure in DNA by helicases" xref: Reactome:651404 "Formation of open bubble structure in DNA by helicases" xref: Reactome:658950 "Formation of open bubble structure in DNA by helicases" xref: Reactome:664657 "Formation of open bubble structure in DNA by helicases" xref: Reactome:670593 "Formation of open bubble structure in DNA by helicases" xref: Reactome:676621 "Formation of open bubble structure in DNA by helicases" xref: Reactome:681735 "Formation of open bubble structure in DNA by helicases" xref: Reactome:687373 "Formation of open bubble structure in DNA by helicases" xref: Reactome:697653 "Formation of open bubble structure in DNA by helicases" xref: Reactome:711444 "Formation of open bubble structure in DNA by helicases" xref: Reactome:725157 "Formation of open bubble structure in DNA by helicases" xref: Reactome:73934 "Formation of open bubble structure in DNA by helicases" is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000718 name: nucleotide-excision repair, DNA damage removal namespace: biological_process def: "The removal of the oligonucleotide that contains the DNA damage. The oligonucleotide is formed by dual incisions that flank the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:562612 "Dual incision reaction in GG-NER" xref: Reactome:588238 "Dual incision reaction in GG-NER" xref: Reactome:608997 "Dual incision reaction in GG-NER" xref: Reactome:633684 "Dual incision reaction in GG-NER" xref: Reactome:645294 "Dual incision reaction in GG-NER" xref: Reactome:655670 "Dual incision reaction in GG-NER" xref: Reactome:660952 "Dual incision reaction in GG-NER" xref: Reactome:666722 "Dual incision reaction in GG-NER" xref: Reactome:672824 "Dual incision reaction in GG-NER" xref: Reactome:678547 "Dual incision reaction in GG-NER" xref: Reactome:683509 "Dual incision reaction in GG-NER" xref: Reactome:689708 "Dual incision reaction in GG-NER" xref: Reactome:701441 "Dual incision reaction in GG-NER" xref: Reactome:716012 "Dual incision reaction in GG-NER" xref: Reactome:727962 "Dual incision reaction in GG-NER" xref: Reactome:73941 "Dual incision reaction in GG-NER" is_a: GO:0006308 ! DNA catabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0000719 name: photoreactive repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers by directly reversing the damage to restore the original pyrimidines." [GOC:elh, PMID:10915863] subset: gosubset_prok synonym: "pyrimidine-dimer repair by photolyase" NARROW [] is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000720 name: pyrimidine dimer repair by nucleotide-excision repair namespace: biological_process def: "The repair of UV-induced T-T, C-T, and C-C dimers by the recognition and removal of the damaged DNA strand from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [GOC:elh] comment: Note that the repair of pyrimidine dimers by nucleotide excision repair involves the same gene products that are involved in general nucleotide excision repair. Consider also annotating to other children of the biological process term 'nucleotide-excision repair ; GO:0006289'. subset: gosubset_prok is_a: GO:0006289 ! nucleotide-excision repair is_a: GO:0006290 ! pyrimidine dimer repair [Term] id: GO:0000721 name: (R,R)-butanediol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reversible reaction: (R,R)-butane-2,3-diol + NAD+ = (R)-acetoin + NADH + H+." [EC:1.1.1.4] subset: gosubset_prok synonym: "(R)-2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "(R)-diacetyl reductase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "1-amino-2-propanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "2,3-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "aminopropanol oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "butylene glycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "butyleneglycol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-(-)-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-1-amino-2-propanol:NAD(2) oxidoreductase activity" EXACT [EC:1.1.1.4] synonym: "D-aminopropanol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "D-butanediol dehydrogenase activity" EXACT [EC:1.1.1.4] synonym: "diacetyl (acetoin) reductase activity" RELATED [EC:1.1.1.4] xref: EC:1.1.1.4 xref: MetaCyc:RR-BUTANEDIOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0000722 name: telomere maintenance via recombination namespace: biological_process def: "Any recombinational process that contributes to the maintenance of proper telomeric length." [GOC:elh, PMID:11850777] synonym: "telomerase-independent telomere maintenance" RELATED [] xref: Reactome:174411 "Polymerase switching on the C-strand of the telomere" xref: Reactome:174414 "Processive synthesis on the C-strand of the telomere" xref: Reactome:174425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:174427 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:174430 "Telomere C-strand synthesis initiation" xref: Reactome:174437 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:174438 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:174439 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:174441 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:174444 "Formation of C-strand Okazaki fragments" xref: Reactome:174445 "RPA binds to the Flap on the C-strand" xref: Reactome:174446 "Removal of remaining Flap from the C-strand" xref: Reactome:174447 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:174448 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:174451 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:174452 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:174456 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:550357 "Formation of C-strand Okazaki fragments" xref: Reactome:550677 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:550726 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:553947 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:554720 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:559668 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:560118 "Removal of remaining Flap from the C-strand" xref: Reactome:560122 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:560148 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:560150 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:560256 "RPA binds to the Flap on the C-strand" xref: Reactome:561063 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:561068 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:563185 "Processive synthesis on the C-strand of the telomere" xref: Reactome:563195 "Polymerase switching on the C-strand of the telomere" xref: Reactome:563364 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:563386 "Telomere C-strand synthesis initiation" xref: Reactome:576985 "Formation of C-strand Okazaki fragments" xref: Reactome:577330 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:577372 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:579849 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:580511 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:585427 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:585893 "Removal of remaining Flap from the C-strand" xref: Reactome:585897 "Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand" xref: Reactome:585923 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:585925 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:586034 "RPA binds to the Flap on the C-strand" xref: Reactome:586824 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:586829 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:588791 "Processive synthesis on the C-strand of the telomere" xref: Reactome:588801 "Polymerase switching on the C-strand of the telomere" xref: Reactome:588985 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:589006 "Telomere C-strand synthesis initiation" xref: Reactome:603330 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:607042 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:609602 "Polymerase switching on the C-strand of the telomere" xref: Reactome:623419 "Formation of C-strand Okazaki fragments" xref: Reactome:623737 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:623780 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:626808 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:627314 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:630994 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:631425 "Removal of remaining Flap from the C-strand" xref: Reactome:631448 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:631450 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:632287 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:632292 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:634220 "Processive synthesis on the C-strand of the telomere" xref: Reactome:634232 "Polymerase switching on the C-strand of the telomere" xref: Reactome:634397 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:634425 "Telomere C-strand synthesis initiation" xref: Reactome:642035 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:644229 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:644231 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:644670 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:644675 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:645781 "Polymerase switching on the C-strand of the telomere" xref: Reactome:645889 "Telomere C-strand synthesis initiation" xref: Reactome:652640 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:654687 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:654689 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:655032 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:655037 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:656104 "Polymerase switching on the C-strand of the telomere" xref: Reactome:656209 "Telomere C-strand synthesis initiation" xref: Reactome:658902 "Formation of C-strand Okazaki fragments" xref: Reactome:658955 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:658968 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:659482 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:659549 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:660352 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:660489 "Removal of remaining Flap from the C-strand" xref: Reactome:660496 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:660498 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:660647 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:660652 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:661221 "Processive synthesis on the C-strand of the telomere" xref: Reactome:661229 "Polymerase switching on the C-strand of the telomere" xref: Reactome:661321 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:661339 "Telomere C-strand synthesis initiation" xref: Reactome:665242 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:666269 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:666271 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:666420 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:666425 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:667046 "Polymerase switching on the C-strand of the telomere" xref: Reactome:667123 "Telomere C-strand synthesis initiation" xref: Reactome:670552 "Formation of C-strand Okazaki fragments" xref: Reactome:670597 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:670610 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:671153 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:671226 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:672143 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:672304 "Removal of remaining Flap from the C-strand" xref: Reactome:672311 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:672313 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:672471 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:672476 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:673139 "Processive synthesis on the C-strand of the telomere" xref: Reactome:673145 "Polymerase switching on the C-strand of the telomere" xref: Reactome:673246 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:673264 "Telomere C-strand synthesis initiation" xref: Reactome:676573 "Formation of C-strand Okazaki fragments" xref: Reactome:676624 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:676637 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:677101 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:677159 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:677946 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:678104 "Removal of remaining Flap from the C-strand" xref: Reactome:678111 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:678113 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:678276 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:678281 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:678834 "Processive synthesis on the C-strand of the telomere" xref: Reactome:678840 "Polymerase switching on the C-strand of the telomere" xref: Reactome:678933 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:678950 "Telomere C-strand synthesis initiation" xref: Reactome:681688 "Formation of C-strand Okazaki fragments" xref: Reactome:681739 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:681752 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:682183 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:682261 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:682934 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:683031 "Removal of remaining Flap from the C-strand" xref: Reactome:683038 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:683040 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:683168 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:683173 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:683766 "Processive synthesis on the C-strand of the telomere" xref: Reactome:683777 "Polymerase switching on the C-strand of the telomere" xref: Reactome:683855 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:683870 "Telomere C-strand synthesis initiation" xref: Reactome:688041 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:689163 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:689165 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:689324 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:689329 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:690047 "Polymerase switching on the C-strand of the telomere" xref: Reactome:690124 "Telomere C-strand synthesis initiation" xref: Reactome:697616 "Formation of C-strand Okazaki fragments" xref: Reactome:697656 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:697671 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:698588 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:698758 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:700185 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:700457 "Removal of remaining Flap from the C-strand" xref: Reactome:700470 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:700472 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:700768 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:700773 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:701766 "Processive synthesis on the C-strand of the telomere" xref: Reactome:701772 "Polymerase switching on the C-strand of the telomere" xref: Reactome:701856 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:701872 "Telomere C-strand synthesis initiation" xref: Reactome:711384 "Formation of C-strand Okazaki fragments" xref: Reactome:711446 "Formation of Processive Complex on the C-strand of the telomere" xref: Reactome:711461 "Formation of the Flap Intermediate on the C-strand" xref: Reactome:712570 "Joining of adjacent Okazaki fragments of the C-strand" xref: Reactome:712786 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:714600 "Recruitment of Dna2 endonuclease to the C strand" xref: Reactome:714958 "Removal of remaining Flap from the C-strand" xref: Reactome:714971 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:714973 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:715287 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:715292 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:716342 "Processive synthesis on the C-strand of the telomere" xref: Reactome:716348 "Polymerase switching on the C-strand of the telomere" xref: Reactome:716430 "Removal of the Flap Intermediate from the C-strand" xref: Reactome:716446 "Telomere C-strand synthesis initiation" xref: Reactome:719533 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:720342 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:720344 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:720466 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:720874 "Polymerase switching on the C-strand of the telomere" xref: Reactome:720954 "Telomere C-strand synthesis initiation" xref: Reactome:725966 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:727416 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:727418 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:727591 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:727596 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:728323 "Polymerase switching on the C-strand of the telomere" xref: Reactome:728404 "Telomere C-strand synthesis initiation" xref: Reactome:730178 "Loading of PCNA - Sliding Clamp Formation on the C-strand of the telomere" xref: Reactome:730615 "RFC binding displaces Pol Alpha on the C-strand of the telomere" xref: Reactome:730617 "RFC dissociates after sliding clamp formation on the C-strand of the telomere" xref: Reactome:730685 "The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer on the G strand of the telomere" xref: Reactome:730690 "The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer on the G strand of the telomere" xref: Reactome:731143 "Polymerase switching on the C-strand of the telomere" xref: Reactome:731183 "Telomere C-strand synthesis initiation" is_a: GO:0000723 ! telomere maintenance is_a: GO:0006312 ! mitotic recombination [Term] id: GO:0000723 name: telomere maintenance namespace: biological_process def: "Any process that contributes to the maintenance of proper telomeric length and structure by affecting and monitoring the activity of telomeric proteins and the length of telomeric DNA. These processes includes those that shorten and lengthen the telomeric DNA sequences." [GOC:elh, PMID:11092831] synonym: "regulation of telomere length" RELATED [GOC:dph, GOC:tb] xref: Reactome:157579 "Telomere Maintenance" xref: Reactome:171306 "Packaging Of Telomere Ends" xref: Reactome:176702 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:548037 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:562857 "Telomere Maintenance" xref: Reactome:575018 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:588477 "Telomere Maintenance" xref: Reactome:609218 "Telomere Maintenance" xref: Reactome:621805 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:633911 "Telomere Maintenance" xref: Reactome:645784 "Telomere Maintenance" xref: Reactome:656107 "Telomere Maintenance" xref: Reactome:658594 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:661047 "Telomere Maintenance" xref: Reactome:666823 "Telomere Maintenance" xref: Reactome:670188 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:672934 "Telomere Maintenance" xref: Reactome:676212 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:678647 "Telomere Maintenance" xref: Reactome:681329 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:683580 "Telomere Maintenance" xref: Reactome:689816 "Telomere Maintenance" xref: Reactome:696862 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:701531 "Telomere Maintenance" xref: Reactome:710415 "Disassociation of Processive Complex and Completed Telomere End" xref: Reactome:716115 "Telomere Maintenance" xref: Reactome:720877 "Telomere Maintenance" xref: Reactome:728079 "Telomere Maintenance" xref: Reactome:731146 "Telomere Maintenance" is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032200 ! telomere organization is_a: GO:0060249 ! anatomical structure homeostasis [Term] id: GO:0000724 name: double-strand break repair via homologous recombination namespace: biological_process alt_id: GO:0016924 def: "The error-free repair of a double-strand break in DNA in which the broken DNA molecule is repaired using homologous sequences. A strand in the broken DNA searches for a homologous region in an intact chromosome to serve as the template for DNA synthesis. The restoration of two intact DNA molecules results in the exchange, reciprocal or nonreciprocal, of genetic material between the intact DNA molecule and the broken DNA molecule." [GOC:elh, PMID:10357855] subset: gosubset_prok synonym: "HDR" EXACT [GOC:vk] synonym: "homologous recombinational repair" EXACT [] synonym: "homology-directed repair" EXACT [GOC:vk] synonym: "HRR" EXACT [] synonym: "Rad51-dependent recombinational repair" EXACT [GOC:mah] synonym: "Rhp51-dependent recombinational repair" EXACT [] xref: Reactome:562635 "Homologous Recombination Repair" xref: Reactome:588261 "Homologous Recombination Repair" xref: Reactome:609254 "Homologous Recombination Repair" xref: Reactome:633970 "Homologous Recombination Repair" xref: Reactome:645533 "Homologous Recombination Repair" xref: Reactome:655886 "Homologous Recombination Repair" xref: Reactome:661071 "Homologous Recombination Repair" xref: Reactome:666850 "Homologous Recombination Repair" xref: Reactome:672965 "Homologous Recombination Repair" xref: Reactome:678684 "Homologous Recombination Repair" xref: Reactome:683624 "Homologous Recombination Repair" xref: Reactome:689849 "Homologous Recombination Repair" xref: Reactome:701574 "Homologous Recombination Repair" xref: Reactome:716158 "Homologous Recombination Repair" xref: Reactome:720743 "Homologous Recombination Repair" xref: Reactome:728120 "Homologous Recombination Repair" xref: Reactome:731005 "Homologous Recombination Repair" xref: Reactome:733059 "Homologous Recombination Repair" xref: Reactome:733894 "Homologous Recombination Repair" xref: Reactome:736610 "Homologous Recombination Repair" xref: Reactome:738590 "Homologous Recombination Repair" xref: Reactome:73888 "Homologous Recombination Repair" is_a: GO:0000725 ! recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0000725 name: recombinational repair namespace: biological_process def: "A DNA repair process that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok xref: Wikipedia:Recombinational_repair is_a: GO:0006281 ! DNA repair is_a: GO:0006310 ! DNA recombination [Term] id: GO:0000726 name: non-recombinational repair namespace: biological_process def: "A DNA repair process in which that does not require the exchange of genetic material between the broken DNA molecule and a homologous region of DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0000727 name: double-strand break repair via break-induced replication namespace: biological_process def: "The error-free repair of a double-strand break in DNA in which the centromere-proximal end of a broken chromosome searches for a homologous region in an intact chromosome. DNA synthesis initiates from the 3' end of the invading DNA strand, using the intact chromosome as the template, and progresses to the end of the chromosome." [GOC:elh, PMID:10357855] subset: gosubset_prok is_a: GO:0000724 ! double-strand break repair via homologous recombination [Term] id: GO:0000728 name: gene conversion at mating-type locus, DNA double-strand break formation namespace: biological_process def: "The site-specific endonucleolytic cleavage of DNA at the mating-type locus which initiates the conversion of one mating-type allele to another." [GOC:elh, PMID:7646483] is_a: GO:0048610 ! reproductive cellular process is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000729 name: DNA double-strand break processing namespace: biological_process def: "The 5' to 3' exonucleolytic resection of the DNA at the site of the break to form a 3' single-strand DNA overhang." [PMID:10357855] xref: Reactome:83897 "Resection of double-strand break ends" is_a: GO:0000738 ! DNA catabolic process, exonucleolytic relationship: part_of GO:0006302 ! double-strand break repair [Term] id: GO:0000730 name: DNA recombinase assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of strand exchange proteins (recombinases) into higher order oligomers on single-stranded DNA." [PMID:10357855] synonym: "Rad51 nucleoprotein filament formation" EXACT [GOC:elh, GOC:vw] xref: Reactome:562932 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:588553 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:609293 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:633985 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:645544 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:655882 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:661072 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:666846 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:672961 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:678680 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:683620 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:689851 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:701587 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:716171 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:720745 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:728121 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:731001 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:733055 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:733890 "Assembly of the RAD51-ssDNA nucleoprotein complex" xref: Reactome:76000 "Assembly of the RAD51-ssDNA nucleoprotein complex" is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0045003 ! double-strand break repair via synthesis-dependent strand annealing [Term] id: GO:0000731 name: DNA synthesis involved in DNA repair namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template." [PMID:10357855] subset: gosubset_prok synonym: "DNA repair synthesis" BROAD [] synonym: "DNA synthesis during DNA repair" RELATED [GOC:dph, GOC:tb] xref: Reactome:76011 "DNA repair synthesis" is_a: GO:0006260 ! DNA replication relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0000732 name: strand displacement namespace: biological_process def: "The rejection of the broken 3' single-strand DNA molecule that formed heteroduplex DNA with its complement in an intact duplex DNA. The Watson-Crick base pairing in the original duplex is restored. The rejected 3' single-strand DNA molecule reanneals with its original complement to reform two intact duplex molecules." [PMID:10357855] subset: gosubset_prok xref: Reactome:83663 "Dissociation of the extended strands" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006310 ! DNA recombination [Term] id: GO:0000733 name: DNA strand renaturation namespace: biological_process def: "The identification and annealing of complementary base pairs in single-strand DNA." [GOC:elh] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000734 name: gene conversion at mating-type locus, DNA repair synthesis namespace: biological_process def: "Synthesis of DNA that proceeds from the broken 3' single-strand DNA end uses the homologous intact duplex as the template during gene conversion at the mating-type locus." [GOC:elh] is_a: GO:0000731 ! DNA synthesis involved in DNA repair relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000735 name: removal of nonhomologous ends namespace: biological_process def: "The removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] is_a: GO:0000737 ! DNA catabolic process, endonucleolytic is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007534 ! gene conversion at mating-type locus [Term] id: GO:0000736 name: double-strand break repair via single-strand annealing, removal of nonhomologous ends namespace: biological_process def: "During DSBR via single-strand annealing, the removal of nonhomologous sequences at the broken 3' single-strand DNA end before DNA repair synthesis can occur." [PMID:10357855] subset: gosubset_prok is_a: GO:0000735 ! removal of nonhomologous ends relationship: part_of GO:0045002 ! double-strand break repair via single-strand annealing [Term] id: GO:0000737 name: DNA catabolic process, endonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, endonucleolytic" EXACT [] synonym: "DNA degradation, endonucleolytic" EXACT [] synonym: "endonucleolytic degradation of DNA" EXACT [] synonym: "endonucleolytic DNA catabolism" EXACT [] is_a: GO:0006308 ! DNA catabolic process [Term] id: GO:0000738 name: DNA catabolic process, exonucleolytic namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of DNA, involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of deoxyribonucleotides." [GOC:elh, GOC:mah] subset: gosubset_prok synonym: "DNA breakdown, exonucleolytic" EXACT [] synonym: "DNA degradation, exonucleolytic" EXACT [] synonym: "exonucleolytic degradation of DNA" EXACT [] is_a: GO:0006308 ! DNA catabolic process [Term] id: GO:0000739 name: DNA strand annealing activity namespace: molecular_function def: "Facilitates the base-pairing of complementary single-stranded DNA." [GOC:elh] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0003697 ! single-stranded DNA binding [Term] id: GO:0000740 name: nuclear membrane fusion namespace: biological_process def: "The joining of 2 or more lipid bilayer membranes that surround the nucleus." [GOC:elh] is_a: GO:0090174 ! organelle membrane fusion [Term] id: GO:0000741 name: karyogamy namespace: biological_process alt_id: GO:0007335 def: "The creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei." [GOC:elh] synonym: "nuclear fusion" EXACT [] synonym: "nuclear fusion during karyogamy" EXACT [] xref: Wikipedia:Karyogamy is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0000742 name: karyogamy involved in conjugation with cellular fusion namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after cytogamy." [GOC:elh] synonym: "karyogamy during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000743 name: nuclear migration involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0006946 def: "The net movement of nuclei towards one another as a prelude to karyogamy in organisms undergoing conjugation with cellular fusion." [GOC:clt] synonym: "nuclear congression" BROAD [] synonym: "nuclear migration during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] is_a: GO:0030473 ! nuclear migration along microtubule is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000744 name: karyogamy involved in conjugation with mutual genetic exchange namespace: biological_process def: "During sexual reproduction, the creation of a single nucleus from multiple nuclei as a result of fusing the lipid bilayers that surround each nuclei. This occurs after the mutual exchange of nuclei." [GOC:elh] synonym: "karyogamy involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000745 name: nuclear migration involved in conjugation with mutual genetic exchange namespace: biological_process def: "The net movement of nuclei towards one another, leading to the bilateral transfer of genetic material in organisms undergoing conjugation without cellular fusion." [GOC:clt, GOC:mah] synonym: "nuclear exchange during conjugation without cellular fusion" RELATED [] synonym: "nuclear migration involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0000744 ! karyogamy involved in conjugation with mutual genetic exchange [Term] id: GO:0000746 name: conjugation namespace: biological_process def: "The union or introduction of genetic information from compatible mating types that results in a genetically different individual. Conjugation requires direct cellular contact between the organisms." [GOC:elh] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Conjugation is_a: GO:0051704 ! multi-organism process [Term] id: GO:0000747 name: conjugation with cellular fusion namespace: biological_process alt_id: GO:0007322 alt_id: GO:0007333 alt_id: GO:0030461 alt_id: GO:0030477 def: "A conjugation process that results in the union of cellular and genetic information from compatible mating types. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: goslim_pombe synonym: "cell fusion" RELATED [] synonym: "mating" RELATED [] is_a: GO:0000746 ! conjugation is_a: GO:0019953 ! sexual reproduction [Term] id: GO:0000748 name: conjugation with mutual genetic exchange namespace: biological_process def: "A conjugation process that results in the mutual exchange and union of only genetic information between compatible mating types. Conjugation without cellular fusion requires direct cellular contact between the organisms without plasma membrane fusion. The organisms involved in conjugation without cellular fusion separate after nuclear exchange." [GOC:elh] synonym: "conjugation without cellular fusion" EXACT [] is_a: GO:0000746 ! conjugation [Term] id: GO:0000749 name: response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007328 alt_id: GO:0030434 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "response to pheromone during conjugation with cellular fusion" RELATED [GOC:dph] is_a: GO:0019236 ! response to pheromone is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000750 name: pheromone-dependent signal transduction involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007330 alt_id: GO:0030454 def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt] synonym: "transduction of mating signal" BROAD [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0032005 ! regulation of conjugation with cellular fusion by signal transduction relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000751 name: cell cycle arrest in response to pheromone namespace: biological_process alt_id: GO:0030571 def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M) as a result of a pheromone stimulus. An example of this process is found in Saccharomyces cerevisiae." [GOC:clt, GOC:dph, GOC:tb] is_a: GO:0007050 ! cell cycle arrest is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000752 name: agglutination involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007334 def: "During conjugation with cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions. An example of this process is agglutination in Saccharomyces cerevisiae." [GOC:elh] synonym: "agglutination" BROAD [] synonym: "cell-cell adhesion during conjugation with cellular fusion" EXACT [] synonym: "cell-cell adhesion during mating" EXACT [] is_a: GO:0000771 ! agglutination involved in conjugation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000753 name: cell morphogenesis involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007332 def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation cellular fusion." [GOC:clt] synonym: "shmoo orientation" NARROW [] synonym: "shmooing" NARROW [] is_a: GO:0000767 ! cell morphogenesis involved in conjugation is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0000749 ! response to pheromone involved in conjugation with cellular fusion [Term] id: GO:0000754 name: adaptation of signaling pathway by response to pheromone involved in conjugation with cellular fusion namespace: biological_process alt_id: GO:0007331 alt_id: GO:0030453 def: "In organisms that undergo conjugation with cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses. An example of this is the adaptation to pheromone during conjugation with cellular fusion in Saccharomyces cerevisiae." [GOC:clt] synonym: "adaptation to pheromone during conjugation with cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation with cellular fusion" EXACT [] is_a: GO:0000749 ! response to pheromone involved in conjugation with cellular fusion is_a: GO:0023058 ! adaptation of signaling pathway [Term] id: GO:0000755 name: cytogamy namespace: biological_process alt_id: GO:0000218 alt_id: GO:0030462 def: "During conjugation with cellular fusion, the process resulting in creating a single cell from complementary mating types. The localized remodeling and dissolution of external protective structures allow the fusion of the plasma membranes and cytoplasmic mixing. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] synonym: "zygote formation" NARROW [] is_a: GO:0022413 ! reproductive process in single-celled organism relationship: part_of GO:0000747 ! conjugation with cellular fusion [Term] id: GO:0000756 name: response to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus during the process of conjugation without cellular fusion." [GOC:clt] synonym: "response to pheromone involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007154 ! cell communication is_a: GO:0019236 ! response to pheromone is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000757 name: signal transduction involved in conjugation with mutual genetic exchange namespace: biological_process def: "A signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "signal transduction involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000758 name: agglutination involved in conjugation with mutual genetic exchange namespace: biological_process def: "During conjugation without cellular fusion, the aggregation or adhesion of compatible mating types via complementary cell-cell interactions." [GOC:elh] synonym: "agglutination involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000771 ! agglutination involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000759 name: cell morphogenesis involved in conjugation with mutual genetic exchange namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo conjugation without cellular fusion." [GOC:clt] synonym: "cellular morphogenesis involved in conjugation without cellular fusion" EXACT [GOC:dph, GOC:tb] is_a: GO:0000767 ! cell morphogenesis involved in conjugation relationship: part_of GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange [Term] id: GO:0000760 name: adaptation to pheromone involved in conjugation with mutual genetic exchange namespace: biological_process def: "In organisms that undergo conjugation without cellular fusion, the process resulting in desensitization following exposure to pheromone stimulus that act to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone involved conjugation without cellular fusion" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during conjugation without cellular fusion" EXACT [] is_a: GO:0000756 ! response to pheromone involved in conjugation with mutual genetic exchange is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000761 name: conjugant formation namespace: biological_process def: "During conjugation without cellular fusion, the process that results in pairing complementary mating types. Localized morphological, cytological, and cytoskeletal changes connect the mating types without cytoplasmic mixing." [GOC:elh] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0000748 ! conjugation with mutual genetic exchange [Term] id: GO:0000762 name: pheromone-induced unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information in response to a pheromone. It involves direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types." [GOC:elh] is_a: GO:0009291 ! unidirectional conjugation [Term] id: GO:0000763 name: cell morphogenesis involved in unidirectional conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo unidirectional conjugation." [GOC:clt] is_a: GO:0000767 ! cell morphogenesis involved in conjugation relationship: part_of GO:0009291 ! unidirectional conjugation [Term] id: GO:0000764 name: cellular morphogenesis involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "The change in form (cell shape and size) that contributes to sexual reproduction in order to facilitate direct contact between the compatible mating types in organisms that undergo pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "cellular morphogenesis during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0000763 ! cell morphogenesis involved in unidirectional conjugation relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000765 name: response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pheromone stimulus that contributes to the process of pheromone-induced unidirectional conjugation." [GOC:clt] synonym: "response to pheromone during pheromone-induced unidirectional" RELATED [GOC:dph, GOC:tb] is_a: GO:0019236 ! response to pheromone relationship: part_of GO:0000762 ! pheromone-induced unidirectional conjugation [Term] id: GO:0000766 name: negative adaptation of signaling pathway by response to pheromone involved in pheromone-induced unidirectional conjugation namespace: biological_process def: "In organisms that undergo pheromone-induced unidirectional conjugation, the process involved in desensitization following exposure to pheromone stimulus that acts to down-regulate further stimulation or block initial conjugation responses." [GOC:clt] synonym: "adaptation to pheromone during pheromone-induced unidirectional conjugation" RELATED [GOC:dph, GOC:tb] synonym: "desensitization to pheromone during pheromone-induced unidirectional conjugation" EXACT [] is_a: GO:0000765 ! response to pheromone involved in pheromone-induced unidirectional conjugation is_a: GO:0022401 ! negative adaptation of signaling pathway [Term] id: GO:0000767 name: cell morphogenesis involved in conjugation namespace: biological_process def: "The change in form (cell shape and size) that occurs during sexual reproduction in order to facilitate direct contact between the compatible mating types." [GOC:elh] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000768 name: syncytium formation by plasma membrane fusion namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by the fusion of the plasma membranes of two or more individual cells." [GOC:mtg_muscle, GOC:tb] synonym: "cell fusion" BROAD [] synonym: "cell-cell fusion" EXACT [] is_a: GO:0006949 ! syncytium formation relationship: has_part GO:0045026 ! plasma membrane fusion [Term] id: GO:0000769 name: syncytium formation by mitosis without cell division namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane, by one or more rounds of nuclear division without cell division." [GOC:tb] is_a: GO:0006949 ! syncytium formation relationship: has_part GO:0033301 ! cell cycle comprising mitosis without cytokinesis [Term] id: GO:0000770 name: peptide pheromone export namespace: biological_process alt_id: GO:0007325 def: "The directed movement of a peptide pheromone out of a cell by a secretion or export pathway used solely for the export of peptide pheromones." [GOC:elh] synonym: "a-factor export" NARROW [] is_a: GO:0015833 ! peptide transport [Term] id: GO:0000771 name: agglutination involved in conjugation namespace: biological_process def: "The aggregation or adhesion of compatible mating types via complementary cell-cell interactions prior to the formation of irreversible cellular contacts during conjugation." [GOC:elh] is_a: GO:0007157 ! heterophilic cell-cell adhesion relationship: part_of GO:0000746 ! conjugation [Term] id: GO:0000772 name: mating pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing a behavioral or physiological response(s) from a responding organism or cell that leads to the transfer or union of genetic material between organisms or cells. The mating pheromone can either be retained on the cell surface or secreted." [GOC:clt, GOC:elh] is_a: GO:0005186 ! pheromone activity [Term] id: GO:0000773 name: phosphatidyl-N-methylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidyl-N-methylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-dimethylethanolamine." [EC:2.1.1.71] subset: gosubset_prok synonym: "methyltransferase II" RELATED [EC:2.1.1.71] synonym: "phosphatidyl-N-methylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidyl-N-monomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phosphatidylethanolamine methyltransferase I" RELATED [EC:2.1.1.71] synonym: "phosphatidylmonomethylethanolamine methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "phospholipid methyltransferase activity" EXACT [EC:2.1.1.71] synonym: "PLMT" EXACT [] synonym: "S-adenosyl-L-methionine:phosphatidyl-N-methylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.71] xref: EC:2.1.1.71 xref: MetaCyc:2.1.1.71-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0000774 name: adenyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins." [GOC:kd] subset: gosubset_prok is_a: GO:0030554 ! adenyl nucleotide binding is_a: GO:0060590 ! ATPase regulator activity [Term] id: GO:0000775 name: chromosome, centromeric region namespace: cellular_component def: "The region of a chromosome that includes the centromeric DNA and associated proteins. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "centromere" RELATED [] synonym: "chromosome, centric region" EXACT [] synonym: "chromosome, pericentric region" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000776 name: kinetochore namespace: cellular_component alt_id: GO:0005699 def: "A multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules." [GOC:elh] subset: goslim_pir xref: Wikipedia:Kinetochore is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0000777 name: condensed chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000776 ! kinetochore intersection_of: GO:0000776 ! kinetochore intersection_of: part_of GO:0000793 ! condensed chromosome relationship: part_of GO:0000779 ! condensed chromosome, centromeric region [Term] id: GO:0000778 name: condensed nuclear chromosome kinetochore namespace: cellular_component def: "A multisubunit complex that is located at the centromeric region of a condensed chromosome in the nucleus and provides an attachment point for the spindle microtubules." [GOC:elh] is_a: GO:0000777 ! condensed chromosome kinetochore is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000776 ! kinetochore intersection_of: part_of GO:0000794 ! condensed nuclear chromosome relationship: part_of GO:0000780 ! condensed nuclear chromosome, centromeric region [Term] id: GO:0000779 name: condensed chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed chromosome, centric region" EXACT [] synonym: "condensed chromosome, centromere" RELATED [] synonym: "condensed chromosome, pericentric region" RELATED [] is_a: GO:0000775 ! chromosome, centromeric region intersection_of: GO:0000775 ! chromosome, centromeric region intersection_of: part_of GO:0000793 ! condensed chromosome relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000780 name: condensed nuclear chromosome, centromeric region namespace: cellular_component def: "The region of a condensed chromosome in the nucleus that includes the centromere and associated proteins, including the kinetochore. In monocentric chromosomes, this region corresponds to a single area of the chromosome, whereas in holocentric chromosomes, it is evenly distributed along the chromosome." [GOC:elh, GOC:kmv] comment: Note that this term can be used in place of the obsolete cellular component term 'centromere ; GO:0005698'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "condensed nuclear chromosome, centric region" EXACT [] synonym: "condensed nuclear chromosome, centromere" RELATED [] synonym: "condensed nuclear chromosome, pericentric region" RELATED [] is_a: GO:0000779 ! condensed chromosome, centromeric region is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000779 ! condensed chromosome, centromeric region intersection_of: part_of GO:0000794 ! condensed nuclear chromosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000781 name: chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "telomere" RELATED [] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000782 name: telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. subset: goslim_pir subset: gosubset_prok is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000781 ! chromosome, telomeric region [Term] id: GO:0000783 name: nuclear telomere cap complex namespace: cellular_component def: "A complex of DNA and protein located at the end of a linear chromosome in the nucleus that protects and stabilizes a linear chromosome." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific protein complex and not a region of the chromosome. is_a: GO:0000782 ! telomere cap complex is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000782 ! telomere cap complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0000784 name: nuclear chromosome, telomeric region namespace: cellular_component def: "The terminal region of a linear chromosome in the nucleus that includes the telomeric DNA repeats and associated proteins." [GOC:elh] comment: Note that this term can be used in place of the obsolete cellular component term 'telomere ; GO:0005696'. Use with caution because this term refers to a specific region of the chromosome and not a protein complex. synonym: "nuclear chromosome, telomere" EXACT [] is_a: GO:0000781 ! chromosome, telomeric region is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000781 ! chromosome, telomeric region intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000785 name: chromatin namespace: cellular_component alt_id: GO:0005717 def: "The ordered and organized complex of DNA and protein that forms the chromosome." [GOC:elh] synonym: "chromosome scaffold" RELATED [] xref: NIF_Subcellular:sao1615953555 is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000786 name: nucleosome namespace: cellular_component alt_id: GO:0005718 def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures." [GOC:elh] subset: goslim_pir xref: Wikipedia:Nucleosome is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000785 ! chromatin [Term] id: GO:0000787 name: cytoplasmic nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the cytoplasm into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000786 ! nucleosome intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000789 ! cytoplasmic chromatin [Term] id: GO:0000788 name: nuclear nucleosome namespace: cellular_component def: "A complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA in the nucleus into higher order structures." [GOC:elh] is_a: GO:0000786 ! nucleosome is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000786 ! nucleosome intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000789 name: cytoplasmic chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the cytoplasm." [GOC:elh] is_a: GO:0000785 ! chromatin is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000790 name: nuclear chromatin namespace: cellular_component def: "The ordered and organized complex of DNA and protein that forms the chromosome in the nucleus." [GOC:elh] is_a: GO:0000785 ! chromatin is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000785 ! chromatin intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000791 name: euchromatin namespace: cellular_component def: "A dispersed and relatively uncompacted form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao445485807 xref: Wikipedia:Euchromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000792 name: heterochromatin namespace: cellular_component def: "A compact and highly condensed form of chromatin." [GOC:elh] xref: NIF_Subcellular:sao581845896 xref: Wikipedia:Heterochromatin is_a: GO:0000785 ! chromatin [Term] id: GO:0000793 name: condensed chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure." [GOC:elh] comment: Note that this term can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes an 'open mitosis' in which the nuclear envelope breaks down during mitosis. synonym: "cytoplasmic mitotic chromosome" RELATED [] synonym: "metaphase chromosome" RELATED [] synonym: "mitotic chromosome" RELATED [] is_a: GO:0005694 ! chromosome [Term] id: GO:0000794 name: condensed nuclear chromosome namespace: cellular_component def: "A highly compacted molecule of DNA and associated proteins resulting in a cytologically distinct structure that remains in the nucleus." [GOC:elh] comment: Note that this term and its children can be used to annotate gene products that localize to a mitotic chromosome in an organism that undergoes a 'closed mitosis' in which the nuclear envelope does not break down during mitosis and for gene products that localize to a meiotic chromosome. synonym: "meiotic chromosome" RELATED [] synonym: "nuclear mitotic chromosome" RELATED [] is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000793 ! condensed chromosome intersection_of: GO:0000793 ! condensed chromosome intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0000795 name: synaptonemal complex namespace: cellular_component alt_id: GO:0005716 def: "A proteinaceous scaffold found between homologous chromosomes during meiosis." [GOC:elh] xref: Wikipedia:Synaptonemal_complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000796 name: condensin complex namespace: cellular_component alt_id: GO:0005676 alt_id: GO:0008620 def: "A multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] subset: goslim_pir synonym: "13S condensin complex" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000793 ! condensed chromosome [Term] id: GO:0000797 name: condensin core heterodimer namespace: cellular_component alt_id: GO:0008621 def: "The core heterodimer of a condensin complex, a multisubunit protein complex that plays a central role in chromosome condensation." [GOC:elh] synonym: "8S condensin complex" NARROW [] synonym: "Smc2-Smc4 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0000796 ! condensin complex relationship: part_of GO:0000796 ! condensin complex [Term] id: GO:0000798 name: nuclear cohesin complex namespace: cellular_component def: "A cohesin complex required for cohesion between sister chromatids that remain in the nucleus." [GOC:elh] comment: Note that this term and its children should be used to annotate gene products found in cohesin complexes in organisms that undergo closed mitosis (i.e. where the nuclear envelope does not break down, as in fungi). For organisms in which the nuclear envelope breaks down during mitosis, the parent should be used. is_a: GO:0008278 ! cohesin complex is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0008278 ! cohesin complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000799 name: nuclear condensin complex namespace: cellular_component def: "A multisubunit protein complex that plays a central role in the condensation of chromosomes that remain in the nucleus." [GOC:elh] is_a: GO:0000796 ! condensin complex is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000796 ! condensin complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0000800 name: lateral element namespace: cellular_component def: "A proteinaceous core found between sister chromatids during meiotic prophase." [GOC:elh] synonym: "axial element" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000801 name: central element namespace: cellular_component def: "A structural unit of the synaptonemal complex found between the lateral elements." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000802 name: transverse filament namespace: cellular_component def: "A structural unit of the synaptonemal complex that spans the regions between the lateral elements and connects them." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000795 ! synaptonemal complex [Term] id: GO:0000803 name: sex chromosome namespace: cellular_component def: "A chromosome involved in sex determination." [GOC:elh] is_a: GO:0005694 ! chromosome [Term] id: GO:0000804 name: W chromosome namespace: cellular_component def: "The sex chromosome present in females of species in which the female is the heterogametic sex; generally, the sex chromosome that pairs with the Z chromosome in the heterogametic sex. The W chromosome is absent from the cells of males and present in one copy in the somatic cells of females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000805 name: X chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the male is the heterogametic sex. Two copies of the X chromosome are present in each somatic cell of females and one copy is present in males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:X_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000806 name: Y chromosome namespace: cellular_component def: "The sex chromosome present in males of species in which the male is the heterogametic sex; generally, the sex chromosome that pairs with the X chromosome in the heterogametic sex. The Y chromosome is absent from the cells of females and present in one copy in the somatic cells of males." [GOC:mah, ISBN:0582227089] xref: Wikipedia:Y_chromosome is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000807 name: Z chromosome namespace: cellular_component def: "The sex chromosome present in both sexes of species in which the female is the heterogametic sex. Two copies of the Z chromosome are present in each somatic cell of males and one copy is present in females." [GOC:mah, ISBN:0321000382] xref: Wikipedia:ZW_sex-determination_system is_a: GO:0000803 ! sex chromosome [Term] id: GO:0000808 name: origin recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome." [GOC:elh] subset: goslim_pir subset: gosubset_prok synonym: "ORC" EXACT [] synonym: "origin of replication recognition complex" EXACT [] xref: Wikipedia:Origin_recognition_complex is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0000809 name: cytoplasmic origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the cytoplasm." [GOC:elh] subset: gosubset_prok synonym: "cytoplasmic ORC" EXACT [] synonym: "prokaryotic ORC" RELATED [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0000808 ! origin recognition complex intersection_of: part_of GO:0005737 ! cytoplasm relationship: part_of GO:0000229 ! cytoplasmic chromosome [Term] id: GO:0000810 name: diacylglycerol pyrophosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diacylglycerol pyrophosphate + H20 = 3-sn-phosphatidate + phosphate." [EC:3.6.1.-, PMID:8567632, PMID:9452443] synonym: "DGPP phosphatase activity" EXACT [] synonym: "DGPP phosphohydrolase activity" EXACT [] is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0000811 name: GINS complex namespace: cellular_component def: "A heterotetrameric protein complex that associates with replication origins, where it is required for the initiation of DNA replication, and with replication forks." [GOC:rn, PMID:12730134, PMID:16990792, PMID:17467990] synonym: "Go, Ichi, Ni and San complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0000812 name: Swr1 complex namespace: cellular_component def: "A multisubunit protein complex that is involved in chromatin remodeling. It is required for the incorporation of the histone variant H2AZ into chromatin. In S. cerevisiae, the complex contains Swr1p, a Swi2/Snf2-related ATPase, and 12 additional subunits." [PMID:14645854, PMID:14690608] synonym: "SWR-C" EXACT [] is_a: GO:0016585 ! chromatin remodeling complex relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0000813 name: ESCRT I complex namespace: cellular_component def: "An endosomal sorting complex required for transport. It consists of the class E vacuolar protein sorting (Vps) proteins and interacts with ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000814 name: ESCRT II complex namespace: cellular_component def: "An endosomal sorting complex required for transport and functions downstream of ESCRT I complex. It consists of the class E vacuolar protein sorting (Vps) proteins and is required for the membrane recruitment of ESCRT III complex and binds to ubiquitinated cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000815 name: ESCRT III complex namespace: cellular_component def: "An endosomal sorting complex required for transport. Consists of two soluble subcomplexes of highly charged coiled-coil proteins and is required for sorting and/or concentration of multivesicular body (MVB) cargoes." [GOC:rb, PMID:12892785, PMID:12900393] synonym: "Endosomal Sorting Complex Required for Transport" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0000816 name: nicotinamide riboside kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinamide riboside = ADP + nicotinamide nucleotide (NMN)." [PMID:15137942] is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0000817 name: COMA complex namespace: cellular_component def: "A multiprotein complex in yeast consisting of Ctf19p, Okp1p, Mcm21p, and Ame1p. This complex bridges the subunits that are in contact with centromeric DNA and the subunits bound to microtubules during kinetochore assembly." [GOC:se, PMID:14633972] synonym: "Ctf19p-Okp1p-Mcm1p-Ame1p complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000818 name: nuclear MIS12/MIND type complex namespace: cellular_component def: "A multiprotein kinetochore subcomplex that binds to centromeric chromatin and forms part of the inner kinetochore of a chromosome in the nucleus. It helps to recruit outer kinetochore subunits that will bind to microtubules. Nuclear localization arises in some organisms because the nuclear envelope is not broken down during mitosis. In S. cerevisiae, it consists of at least four proteins: Mtw1p, Nnf1p, Nsl1p, and Dsn1." [GOC:krc, GOC:se, PMID:14633972] synonym: "MIND complex" EXACT [] synonym: "Mtw1p Including Nnf1p-Nsl1p-Dsn1p complex" EXACT [] is_a: GO:0000444 ! MIS12/MIND type complex is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000444 ! MIS12/MIND type complex intersection_of: part_of GO:0005634 ! nucleus relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000819 name: sister chromatid segregation namespace: biological_process def: "The process by which sister chromatids are organized and then physically separated and apportioned to two or more sets." [GOC:ai, GOC:elh] is_a: GO:0007059 ! chromosome segregation is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization [Term] id: GO:0000820 name: regulation of glutamine family amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:go_curators] synonym: "regulation of glutamine family amino acid metabolism" EXACT [] is_a: GO:0006521 ! regulation of cellular amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009064 ! glutamine family amino acid metabolic process relationship: regulates GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0000821 name: regulation of arginine metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] synonym: "regulation of arginine metabolism" EXACT [] is_a: GO:0000820 ! regulation of glutamine family amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006525 ! arginine metabolic process relationship: regulates GO:0006525 ! arginine metabolic process [Term] id: GO:0000822 name: inositol hexakisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with inositol hexakisphosphate." [GOC:go_curators] synonym: "InsP6 binding" EXACT [] synonym: "IP6 binding" EXACT [] is_a: GO:0043178 ! alcohol binding [Term] id: GO:0000823 name: inositol trisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate." [GOC:elh] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 6-phosphotransferase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0000824 name: inositol tetrakisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5,6-tetrakisphosphate = ADP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "EC:2.7.1.151" BROAD [] synonym: "inositol 1,4,5,6-tetrakisphosphate 3-kinase activity" EXACT [] synonym: "inositol polyphosphate multikinase activity" BROAD [] synonym: "IpmK" BROAD [] is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000825 name: inositol tetrakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,3,4,5-tetrakisphosphate + ATP = 1D-myo-inositol 1,3,4,5,6-pentakisphosphate + ADP." [GOC:elh] synonym: "1D-myo-inositol-tetrakisphosphate 6-kinase activity" EXACT [] synonym: "inositol 1,3,4,5-tetrakisphosphate 6-kinase activity" EXACT [] is_a: GO:0051765 ! inositol tetrakisphosphate kinase activity [Term] id: GO:0000826 name: inositol pyrophosphate synthase activity namespace: molecular_function def: "Catalysis of the phosphorylation of inositol phosphates which possess pyrophosphate bonds." [GOC:elh, PMID:16429326] synonym: "inositol diphosphate synthase activity" EXACT [] is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0000827 name: inositol 1,3,4,5,6-pentakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,3,4,5,6-pentakisphosphate = ADP + diphospho-1D-myo-inositol tetrakisphosphate (isomeric configuration unknown)." [GOC:elh, PMID:11311242] synonym: "EC:2.7.4.21" BROAD [] is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000828 name: inositol hexakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate (IP6) = ADP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown)." [GOC:elh, PMID:16429326] xref: MetaCyc:2.7.1.152-RXN is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000829 name: inositol heptakisphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + diphospho-1D-myo-inositol-pentakisphosphate (PP-IP5; isomer unknown) = ADP + bis(diphospho)-1D-myo-inositol-tetrakisphosphate (bis-PP-IP4; isomer unknown)." [GOC:elh, PMID:16429326] is_a: GO:0000826 ! inositol pyrophosphate synthase activity [Term] id: GO:0000830 name: inositol hexakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000831 name: inositol hexakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033187 ! inositol hexakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000832 name: inositol hexakisphosphate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol hexakisphosphate = ADP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate." [GOC:elh, PMID:16429326] synonym: "ATP:1D-myo-inositol-hexakisphosphate 5-phosphotransferase activity" EXACT [] synonym: "EC:2.7.4.21" BROAD [] is_a: GO:0000828 ! inositol hexakisphosphate kinase activity [Term] id: GO:0000833 name: inositol heptakisphosphate 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate." [GOC:elh, PMID:16429326] synonym: "diphosphoinositol-pentakisphosphate 4-kinase activity" EXACT [] synonym: "IP7 4-kinase activity" EXACT [] is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000834 name: inositol heptakisphosphate 6-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-diphospho-1D-myo-inositol (1,2,3,4,6)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate." [GOC:elh, PMID:16429326] is_a: GO:0033199 ! inositol heptakisphosphate 4-kinase or 6-kinase activity [Term] id: GO:0000835 name: ER ubiquitin ligase complex namespace: cellular_component def: "A ubiquitin ligase complex found in the ER." [GOC:elh] is_a: GO:0000153 ! cytoplasmic ubiquitin ligase complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part intersection_of: GO:0000151 ! ubiquitin ligase complex intersection_of: part_of GO:0005783 ! endoplasmic reticulum relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0000836 name: Hrd1p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal and membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000837 name: Doa10p ubiquitin ligase complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates membranes proteins with misfolded cytosolic domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Ssm4p/Doa10p." [GOC:elh, PMID:16873066] synonym: "Ssm4p ubiquitin ligase complex" EXACT [] is_a: GO:0000835 ! ER ubiquitin ligase complex [Term] id: GO:0000838 name: Hrd1p ubiquitin ligase ERAD-M complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded membrane domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000839 name: Hrd1p ubiquitin ligase ERAD-L complex namespace: cellular_component def: "A multiprotein complex that recognizes and ubiquitinates proteins with misfolded luminal domains during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligase Hrd1p." [GOC:elh, PMID:16873065, PMID:16873066] is_a: GO:0000836 ! Hrd1p ubiquitin ligase complex [Term] id: GO:0000900 name: translation repressor activity, nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide via direct binding to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0090079 ! translation regulator activity, nucleic acid binding [Term] id: GO:0000901 name: translation repressor activity, non-nucleic acid binding namespace: molecular_function def: "Antagonizes the ribosome-mediated translation of mRNA into a polypeptide but does not bind directly to nucleic acid." [GOC:clt] is_a: GO:0030371 ! translation repressor activity is_a: GO:0045183 ! translation factor activity, non-nucleic acid binding [Term] id: GO:0000902 name: cell morphogenesis namespace: biological_process alt_id: GO:0007148 alt_id: GO:0045790 alt_id: GO:0045791 def: "The developmental process by which the size or shape of a cell is generated and organized. Morphogenesis pertains to the creation of form." [GOC:clt, GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "cellular morphogenesis" EXACT [] is_a: GO:0032989 ! cellular component morphogenesis [Term] id: GO:0000903 name: cell morphogenesis during vegetative growth phase namespace: biological_process def: "The change in cell shape that occurs during the vegetative growth phase. The vegetative growth phase is the growth phase during which single celled organisms reproduce by budding or other asexual methods." [GOC:clt, GOC:go_curators] synonym: "cellular morphogenesis during vegetative growth" EXACT [GOC:dph, GOC:tb] is_a: GO:0000902 ! cell morphogenesis [Term] id: GO:0000904 name: cell morphogenesis involved in differentiation namespace: biological_process def: "The change in form (cell shape and size) that occurs when relatively unspecialized cells, e.g. embryonic or regenerative cells, acquire specialized structural and/or functional features that characterize the cells, tissues, or organs of the mature organism or some other relatively stable phase of the organism's life history." [GOC:go_curators] is_a: GO:0000902 ! cell morphogenesis relationship: part_of GO:0048468 ! cell development [Term] id: GO:0000905 name: sporocarp development involved in asexual reproduction namespace: biological_process def: "The formation of a spore-bearing structure by fungus where spores will arise from asexual reproduction." [GOC:clt, GOC:mtg_sensu] synonym: "conidium development" NARROW [] synonym: "fruiting body formation involved in asexual reproduction" BROAD [] synonym: "haploid fruiting" RELATED [] synonym: "homokaryotic fruiting" RELATED [] synonym: "imperfect stage fruiting body development" NARROW [] synonym: "monokaryotic fruiting" RELATED [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019954 ! asexual reproduction [Term] id: GO:0000906 name: 6,7-dimethyl-8-ribityllumazine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxy-2-butanone 4-phosphate + 5-amino-6-ribitylamino-2,4(1H,3H)-pyrimidinedione = 6,7-dimethyl-8-ribityllumazine + phosphate." [EC:5.4.-.-, PMID:7559556] synonym: "lumazine synthase activity" BROAD [MetaCyc:LUMAZINESYN-CPLX] xref: EC:5.4.-.- is_a: GO:0016867 ! intramolecular transferase activity, transferring acyl groups [Term] id: GO:0000907 name: sulfonate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: sulfonate + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.-, GOC:clt, PMID:10482536] subset: gosubset_prok synonym: "sulfonate/alpha-ketoglutarate dioxygenase activity" EXACT [] synonym: "sulphonate dioxygenase activity" EXACT [] xref: EC:1.14.11.- is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0000908 name: taurine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: taurine + 2-oxoglutarate + O2 = SO3(2-) (sulfite) + aminoacetaldehyde + succinate + CO2." [EC:1.14.11.17, MetaCyc:RXN0-299] subset: gosubset_prok synonym: "2-aminoethanesulfonate dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "alpha-ketoglutarate-dependent taurine dioxygenase activity" EXACT [EC:1.14.11.17] synonym: "taurine, 2-oxoglutarate:O2 oxidoreductase (sulfite-forming)" EXACT [EC:1.14.11.17] xref: EC:1.14.11.17 xref: MetaCyc:RXN0-299 is_a: GO:0000907 ! sulfonate dioxygenase activity [Term] id: GO:0000909 name: sporocarp development involved in sexual reproduction namespace: biological_process def: "The process whose specific outcome is the progression of a fruiting body organ over time, from its formation to the mature structure. The fruiting body is a spore bearing structure. In fungi, the sporocarp (also known as fruiting body) is a multicellular structure on which spore-producing structures, such as basidia or asci, are borne. The fruiting body is part of the sexual phase of a fungal life cycle, with the rest of the life cycle being characterized by vegetative mycelial growth. The sporocarp of a basidiomycete is known as a basidiocarp, while the fruiting body of an ascomycete is known as an ascocarp. A significant range of different shapes and morphologies is found in both basidiocarps and ascocarps; these features play an important role in the identification and taxonomy of fungi." [GOC:clt, GOC:mtg_sensu] synonym: "ascus development" NARROW [] synonym: "fruiting body development involved in sexual reproduction" BROAD [] synonym: "fruiting body formation involved in sexual reproduction" BROAD [] synonym: "perfect stage fruiting body development" NARROW [] is_a: GO:0030584 ! sporocarp development relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0000910 name: cytokinesis namespace: biological_process alt_id: GO:0007104 alt_id: GO:0016288 def: "A cellular process resulting in the division of the cytoplasm of a cell and its separation into two daughter cells. Cytokinesis usually occurs after growth, replication, and segregation of cellular components." [GOC:ai] subset: goslim_candida subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok xref: Reactome:563366 "Mitotic Telophase /Cytokinesis" xref: Reactome:588987 "Mitotic Telophase /Cytokinesis" xref: Reactome:609703 "Mitotic Telophase /Cytokinesis" xref: Reactome:634401 "Mitotic Telophase /Cytokinesis" xref: Reactome:645864 "Mitotic Telophase /Cytokinesis" xref: Reactome:656182 "Mitotic Telophase /Cytokinesis" xref: Reactome:661326 "Mitotic Telophase /Cytokinesis" xref: Reactome:673252 "Mitotic Telophase /Cytokinesis" xref: Reactome:678938 "Mitotic Telophase /Cytokinesis" xref: Reactome:683860 "Mitotic Telophase /Cytokinesis" xref: Reactome:68884 "Mitotic Telophase /Cytokinesis" xref: Reactome:690112 "Mitotic Telophase /Cytokinesis" xref: Reactome:720937 "Mitotic Telophase /Cytokinesis" xref: Reactome:728389 "Mitotic Telophase /Cytokinesis" xref: Wikipedia:Cytokinesis is_a: GO:0051301 ! cell division [Term] id: GO:0000911 name: cytokinesis by cell plate formation namespace: biological_process def: "The process of dividing the cytoplasm of a parent cell where a structure forms in the cytoplasm and grows until reaching the plasma membrane, thereby completely separating the cytoplasms of adjacent progeny cells. An example of this is found in Arabidopsis thaliana." [GOC:clt] is_a: GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000912 name: assembly of actomyosin apparatus involved in cell cycle cytokinesis namespace: biological_process def: "The assembly and arrangement of an apparatus composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:mah] synonym: "actomyosin apparatus assembly involved in cytokinesis" EXACT [GOC:mah] synonym: "cytokinesis, formation of actomyosin apparatus" EXACT [GOC:dph, GOC:tb] synonym: "formation of actomyosin apparatus involved in cytokinesis" RELATED [GOC:dph] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000913 name: preprophase band assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the preprophase band, a dense band of microtubules that marks the position in the cell where cytokinesis will occur in cells that perform cytokinesis by cell plate formation." [GOC:clt, GOC:mah] synonym: "preprophase band formation" RELATED [GOC:mah] is_a: GO:0007105 ! cytokinesis, site selection is_a: GO:0022607 ! cellular component assembly relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000914 name: phragmoplast assembly namespace: biological_process def: "The formation of a structure composed of actin, myosin, and associated proteins that will function in cytokinesis in cells that perform cytokinesis by cell plate formation. The structure usually contains antiparallel microtubules and membrane (often visible as vesicles)." [GOC:clt] synonym: "phragmoplast formation" RELATED [goc:dph] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000915 name: cytokinesis, actomyosin contractile ring assembly namespace: biological_process alt_id: GO:0045573 def: "The process of assembly of a ring composed of actin, myosin, and associated proteins that will function in cytokinesis." [GOC:clt, GOC:dph, GOC:tb] synonym: "constriction ring assembly" NARROW [] synonym: "contractile ring assembly" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin contractile ring formation" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring biosynthesis" RELATED [] synonym: "cytokinesis, actomyosin ring formation" RELATED [] synonym: "cytokinesis, contractile ring assembly" RELATED [GOC:mah] is_a: GO:0000912 ! assembly of actomyosin apparatus involved in cell cycle cytokinesis [Term] id: GO:0000916 name: contractile ring contraction involved in cell cycle cytokinesis namespace: biological_process def: "The process of an actomyosin ring getting smaller in diameter, in the context of cytokinesis that takes place as part of a cell cycle." [GOC:clt, GOC:dph, GOC:mah, GOC:tb] synonym: "contractile ring constriction" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "cytokinesis, actomyosin ring contraction" EXACT [] synonym: "cytokinesis, contractile ring contraction" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0033205 ! cell cycle cytokinesis [Term] id: GO:0000917 name: barrier septum formation namespace: biological_process def: "The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a barrier septum are not able to exchange intracellular material." [GOC:clt, GOC:mah] synonym: "barrier septum assembly" EXACT [GOC:mah] synonym: "formation of barrier septum" EXACT [] synonym: "septation" BROAD [] synonym: "septin assembly and septum biosynthesis" RELATED [] synonym: "septin assembly and septum formation" RELATED [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0000918 name: selection of site for barrier septum formation namespace: biological_process def: "The process of marking the site where a barrier septum will form." [GOC:clt] synonym: "selection of site for barrier cell septum biosynthesis" EXACT [] synonym: "selection of site for barrier cell septum formation" EXACT [] synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] synonym: "septum positioning" EXACT [] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000917 ! barrier septum formation [Term] id: GO:0000919 name: cell plate assembly namespace: biological_process def: "The process of assembly, maturation, and growth of the cell plate to the cell periphery in cells that divide by cell plate formation; often involves deposition of cell wall material in and around the phragmoplast." [GOC:clt] synonym: "cell plate formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000911 ! cytokinesis by cell plate formation [Term] id: GO:0000920 name: cytokinetic cell separation namespace: biological_process def: "The process of physically separating progeny cells during cytokinesis; this may involve enzymatic digestion of septum or cell wall components." [GOC:clt] synonym: "cell separation during cytokinesis" RELATED [GOC:dph, GOC:tb] synonym: "rotokinesis" NARROW [] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0000921 name: septin ring assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of septins and associated proteins to form an organized structure resembling a ring at the cell cortex." [GOC:clt] subset: gosubset_prok synonym: "septin assembly and septum biosynthesis" BROAD [] synonym: "septin assembly and septum formation" BROAD [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0031106 ! septin ring organization [Term] id: GO:0000922 name: spindle pole namespace: cellular_component alt_id: GO:0030615 def: "Either of the ends of a spindle, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules." [GOC:clt] is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0000923 name: equatorial microtubule organizing center namespace: cellular_component def: "A microtubule organizing center formed by a band of gamma-tubulin that is recruited to a circumferential band of F-actin at the midpoint of a cell and which nucleates microtubules from the cell division site at the end of mitosis." [PMID:11792817] synonym: "EMTOC" EXACT [] synonym: "equatorial microtubule organising centre" EXACT [] is_a: GO:0005815 ! microtubule organizing center is_a: GO:0032155 ! cell division site part intersection_of: GO:0005815 ! microtubule organizing center intersection_of: part_of GO:0032153 ! cell division site [Term] id: GO:0000924 name: gamma-tubulin ring complex, centrosomal namespace: cellular_component alt_id: GO:0000925 alt_id: GO:0000926 def: "A centrosome-localized multiprotein complex composed of gamma-tubulin and other non-tubulin proteins assembled into a ring structure that is thought to be the unit of nucleation at the minus end of a microtubule. Gamma-tubulin small complexes are thought to be the core repeating units of the ring." [GOC:clt, GOC:mtg_sensu, PMID:12134075, PMID:17021256] synonym: "gamma-tubulin large complex, centrosomal" EXACT [] is_a: GO:0008274 ! gamma-tubulin ring complex intersection_of: GO:0008274 ! gamma-tubulin ring complex intersection_of: part_of GO:0000242 ! pericentriolar material relationship: part_of GO:0000242 ! pericentriolar material [Term] id: GO:0000927 name: gamma-tubulin small complex, centrosomal namespace: cellular_component def: "A centrosomal complex usually comprising two gamma-tubulin molecules, at least two conserved non-tubulin proteins that multimerize along with additional non-tubulin proteins in animal cells into larger functional complexes. Gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex. An example of this structure is found in Mus musculus." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0008275 ! gamma-tubulin small complex [Term] id: GO:0000928 name: gamma-tubulin small complex, spindle pole body namespace: cellular_component def: "A complex composed of two gamma-tubulin molecules and conserved non-tubulin proteins isolated by fractionation from cells. The complex, approximately 6S-9S, is analogous to the small complex in animal cells but contains fewer subunits, and is not thought to multimerize into larger functional units, like complexes in those organisms. An example of this structure is found in Saccharomyces cerevisiae." [GOC:mtg_sensu, PMID:12134075] synonym: "Tub4 complex" EXACT [] is_a: GO:0008275 ! gamma-tubulin small complex intersection_of: GO:0008275 ! gamma-tubulin small complex intersection_of: part_of GO:0005816 ! spindle pole body relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0000930 name: gamma-tubulin complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins. Gamma-tubulin complexes are localized to microtubule organizing centers, and play an important role in the nucleation of microtubules. The number and complexity of non-tubulin proteins associated with these complexes varies between species." [GOC:clt, PMID:12134075] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044450 ! microtubule organizing center part [Term] id: GO:0000931 name: gamma-tubulin large complex namespace: cellular_component alt_id: GO:0000929 def: "A complex of gamma tubulin and associated proteins thought to be formed by multimerization of gamma-tubulin small complexes. An example of this structure is found in Schizosaccharomyces pombe." [GOC:mtg_sensu, PMID:12134075] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0000932 name: cytoplasmic mRNA processing body namespace: cellular_component def: "A focus in the cytoplasm where mRNAs may become inactivated by decapping or some other mechanism. mRNA processing and binding proteins are localized to these foci." [GOC:clt, PMID:12730603] synonym: "cytoplasmic foci" RELATED [] synonym: "P body" EXACT [] synonym: "P-body" EXACT [] xref: Wikipedia:P_body is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0000933 name: adventitious septum namespace: cellular_component def: "A cell septum whose formation is independent of nuclear division." [GOC:clt, ISBN:0471940526] is_a: GO:0030428 ! cell septum [Term] id: GO:0000934 name: porous cell septum namespace: cellular_component def: "A septum or cross wall which does not entirely span the space between two portions of cell wall and may contain a specialized central pore structure. A porous septum allows the movement of organelles and/or cytoplasm between compartments." [GOC:clt] synonym: "porous septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000935 name: barrier septum namespace: cellular_component def: "A septum which spans a cell and does not allow exchange of organelles or cytoplasm between compartments." [GOC:clt] synonym: "complete septum" EXACT [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000936 name: primary cell septum namespace: cellular_component def: "A cell septum that forms following nuclear division." [GOC:clt, ISBN:0471940526] synonym: "primary septum" BROAD [] is_a: GO:0030428 ! cell septum [Term] id: GO:0000937 name: dolipore septum namespace: cellular_component def: "A septum, or cross-wall, between two portions of a cell or hypha; contains a central pore around which the septum is swollen to form a barrel-shaped structure; pore is covered on each side of the septum by a septal pore cap (parenthosome)." [GOC:clt] is_a: GO:0000934 ! porous cell septum [Term] id: GO:0000938 name: GARP complex namespace: cellular_component def: "A quatrefoil tethering complex required for retrograde traffic from the early endosome back to the late Golgi and biogenesis of cytoplasmic vesicles." [GOC:clt, GOC:rn, PMID:10637310, PMID:12077354, PMID:12446664] synonym: "Golgi associated retrograde protein complex" EXACT [] synonym: "VFT tethering complex" EXACT [] synonym: "Vps fifty three tethering complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0016023 ! cytoplasmic membrane-bounded vesicle [Term] id: GO:0000939 name: inner kinetochore of condensed chromosome namespace: cellular_component def: "The region of a condensed chromosome kinetochore closest to centromeric DNA; in mammals the CREST antigens (CENP proteins) are found in this layer; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:11483983] synonym: "inner centromere core complex" RELATED [] synonym: "inner kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000940 name: outer kinetochore of condensed chromosome namespace: cellular_component def: "The region of a condensed chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:11483983] synonym: "outer kinetochore plate" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0000777 ! condensed chromosome kinetochore [Term] id: GO:0000941 name: inner kinetochore of condensed nuclear chromosome namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore closest to centromeric DNA; this layer may help define underlying centromeric chromatin structure and position of the kinetochore on the chromosome." [GOC:clt, PMID:10619130, PMID:1148398] is_a: GO:0000939 ! inner kinetochore of condensed chromosome is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000939 ! inner kinetochore of condensed chromosome intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000942 name: outer kinetochore of condensed nuclear chromosome namespace: cellular_component def: "The region of a condensed nuclear chromosome kinetochore most external to centromeric DNA; this outer region mediates kinetochore-microtubule interactions." [GOC:clt, PMID:1148398] is_a: GO:0000940 ! outer kinetochore of condensed chromosome is_a: GO:0044454 ! nuclear chromosome part intersection_of: GO:0000940 ! outer kinetochore of condensed chromosome intersection_of: part_of GO:0000778 ! condensed nuclear chromosome kinetochore relationship: part_of GO:0000778 ! condensed nuclear chromosome kinetochore [Term] id: GO:0000943 name: retrotransposon nucleocapsid namespace: cellular_component def: "A complex of the retrotransposon RNA genome, reverse transcriptase, integrase, and associated molecules required for reproduction and integration of the retrotransposon into the host genome; the main structural molecule of the nucleocapsid is often a gag protein homolog." [GOC:clt, PMID:10861903] synonym: "Virus-like particle" EXACT [] synonym: "VLP" EXACT [] xref: Wikipedia:Virus-like_particle is_a: GO:0044428 ! nuclear part [Term] id: GO:0000944 name: base pairing with rRNA namespace: molecular_function def: "Interacting selectively and non-covalently with ribosomal ribonucleic acid (rRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target rRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0019843 ! rRNA binding [Term] id: GO:0000945 name: base pairing with snRNA namespace: molecular_function def: "Interacting selectively and non-covalently with small nuclear ribonucleic acid (snRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target snRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000498 ! base pairing with RNA is_a: GO:0017069 ! snRNA binding [Term] id: GO:0000946 name: base pairing with tRNA namespace: molecular_function def: "Interacting selectively and non-covalently with transfer ribonucleic acid (mRNA) via hydrogen bonds between the bases of a gene product molecule and the bases of a target tRNA molecule." [GOC:krc] comment: Note that with respect to annotation, "base pairing with RNA" and its child terms are intended to be used to annotate the activity of gene products composed of nucleic acid, presumably RNA, to interact with other RNA molecules via base pairing. Internal base pairing with itself is considered part of the secondary structure of the molecule and is not within the scope of GO function. is_a: GO:0000049 ! tRNA binding is_a: GO:0000498 ! base pairing with RNA [Term] id: GO:0000947 name: amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046165 ! alcohol biosynthetic process [Term] id: GO:0000948 name: amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000955 ! amino acid catabolic process via Ehrlich pathway is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0000949 name: aromatic amino acid family catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of aromatic amino acids to produce aromatic alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanol, 4-hydroxyphenylethanol, or tryptophol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000950 name: branched chain family amino acid catabolic process to alcohol via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanol, 2-methylbutanol, or 2-methylpropanol, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0000951 name: methionine catabolic process to 3-methylthiopropanol namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of branched chain amino acids to produce branched chain alcohols with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanol is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0000947 ! amino acid catabolic process to alcohol via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0000952 name: aromatic amino acid family catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When an aromatic family amino acid, phenylalanine, tyrosine, or tryptophan, is used as the substrate, 2-phenylethanoate, 4-hydroxyphenylethanoate, or 2-(Indol-3-yl)-ethanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0000953 name: branched chain family amino acid catabolic process to carboxylic acid via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When a branched chain family amino acid, leucine, isoleucine, or valine, is used as the substrate, 3-methylbutanoate, 2-methylbutanoate, or 2-methylpropanoate, respectively, is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0000954 name: methionine catabolic process to 3-methylthiopropanoate namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce carboxylic acids with one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. When methionine is used as the substrate, 3-methylthiopropanoate is produced. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of carboxylic acids, sometimes collectively referred to as fusel acids. Depending on the redox state of the cells, alcohol derivatives may be produced instead of carboxylic acids." [GOC:krc, PMID:18281432] is_a: GO:0000948 ! amino acid catabolic process to carboxylic acid via Ehrlich pathway is_a: GO:0009087 ! methionine catabolic process [Term] id: GO:0000955 name: amino acid catabolic process via Ehrlich pathway namespace: biological_process def: "The chemical reactions and pathways involving the catabolism of amino acids to produce alcohols or carboxylic acids containing one carbon less than the starting amino acid. In S. cerevisiae, this is known to occur for leucine, isoleucine, valine, methionine, phenylalanine, tyrosine, or tryptophan. Often referred to as the Ehrlich pathway, these reactions generally occur during fermentation to produce a variety of alcohols, often collectively referred to as fusel alcohols. Depending on the redox state of the cells, carboxylic acid derivatives, sometimes referred to as fusel acids, may be produced instead of alcohols." [GOC:krc, PMID:18281432] is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0000956 name: nuclear-transcribed mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nuclear-transcribed mRNAs in eukaryotic cells." [GOC:krc] synonym: "nuclear mRNA breakdown" EXACT [] synonym: "nuclear mRNA catabolism" EXACT [] synonym: "nuclear mRNA degradation" EXACT [] is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000957 name: mitochondrial RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006401 ! RNA catabolic process [Term] id: GO:0000958 name: mitochondrial mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000957 ! mitochondrial RNA catabolic process is_a: GO:0006402 ! mRNA catabolic process [Term] id: GO:0000959 name: mitochondrial RNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving RNA transcribed from the mitochondrial genome and occurring in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0000960 name: regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000961 name: negative regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0051253 ! negative regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: negatively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000962 name: positive regulation of mitochondrial RNA catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving catabolism in the mitochondrion of RNA transcribed from the mitochondrial genome." [GOC:krc, GOC:mah] is_a: GO:0000960 ! regulation of mitochondrial RNA catabolic process is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0051254 ! positive regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process relationship: positively_regulates GO:0000957 ! mitochondrial RNA catabolic process [Term] id: GO:0000963 name: mitochondrial RNA processing namespace: biological_process def: "The conversion of a primary RNA molecule transcribed from a mitochondrial genome into one or more mature RNA molecules; occurs in the mitochondrion." [GOC:krc, GOC:mah] is_a: GO:0000959 ! mitochondrial RNA metabolic process is_a: GO:0006396 ! RNA processing [Term] id: GO:0000964 name: mitochondrial RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 5' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0000966 ! RNA 5'-end processing [Term] id: GO:0000965 name: mitochondrial RNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of an RNA molecule transcribed from a mitochondrial genome; occurs in the mitochondrion." [GOC:krc, GOC:mah] synonym: "mitochondrial RNA 3' end processing" RELATED [] is_a: GO:0000963 ! mitochondrial RNA processing is_a: GO:0031123 ! RNA 3'-end processing [Term] id: GO:0000966 name: RNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an RNA molecule." [GOC:krc] synonym: "RNA 5' end processing" EXACT [] is_a: GO:0006396 ! RNA processing [Term] id: GO:0000967 name: rRNA 5'-end processing namespace: biological_process def: "Any process involved in forming the mature 5' end of an rRNA molecule." [GOC:krc] synonym: "rRNA 5' end processing" EXACT [] is_a: GO:0034471 ! ncRNA 5'-end processing [Term] id: GO:0000968 name: tRNA exon ligation namespace: biological_process def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined." [GOC:krc] is_a: GO:0000378 ! RNA exon ligation relationship: part_of GO:0006388 ! tRNA splicing, via endonucleolytic cleavage and ligation created_by: kchris creation_date: 2009-04-28T10:22:40Z [Term] id: GO:0000969 name: tRNA exon ligation utilizing ATP as source of linkage phosphate namespace: biological_process def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from exogenous ATP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in vertebrate species." [GOC:krc, PMID:17786051] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:29:37Z [Term] id: GO:0000970 name: tRNA exon ligation utilizing GTP as source of linkage phosphate namespace: biological_process def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from exogenous GTP. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in the yeast Saccharomyces cerevisiae where the ligation reaction also produces a 2'-phosphate at the splice junction which is subsequently removed as part of the ligation process." [GOC:krc, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:33:25Z [Term] id: GO:0000971 name: tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate namespace: biological_process def: "The process by which the two exons of a pre-tRNA which has had the intron removed are rejoined where the splice junction phosphate is derived from the 2',3' cyclic phosphate at the 3'-end of the 5'-exon. This type of ligation to rejoin the 5' and 3' exons of a tRNA is observed in wheat, Chlamydomonas, and vertebrate species including humans." [GOC:krc, PMID:17786051, PMID:18217203, PMID:9299409] is_a: GO:0000968 ! tRNA exon ligation created_by: kchris creation_date: 2009-04-28T10:36:17Z [Term] id: GO:0000972 name: transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The process by which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery. In S. cerevisiae, this process involves cis-acting DNA sequences such as the TATA box and upstream activating sequence (UAS) elements, trans-acting transcriptional activators, and also the 3'-UTR of the transcript." [GOC:krc, PMID:18614049] is_a: GO:0051276 ! chromosome organization created_by: kchris creation_date: 2009-09-10T12:25:11Z [Term] id: GO:0000973 name: posttranscriptional tethering of RNA polymerase II gene DNA at nuclear periphery namespace: biological_process def: "The process by which the DNA sequence containing a gene transcribed by RNA polymerase II is maintained in a specific location at the nuclear periphery even after transcription has been repressed." [GOC:krc, PMID:17373856, PMID:18614049] is_a: GO:0000972 ! transcription-dependent tethering of RNA polymerase II gene DNA at nuclear periphery created_by: kchris creation_date: 2009-09-10T12:28:04Z [Term] id: GO:0000974 name: Prp19 complex namespace: cellular_component def: "A protein complex consisting of Prp19 and associated proteins that is involved in the transition from the precatalytic spliceosome to the activated form that catalyzes step 1 of splicing, and which remains associated with the spliceosome through the second catalytic step. It is widely conserved, found in both yeast and mammals, though the exact composition varies. In S. cerevisiae, it contains Prp19p, Ntc20p, Snt309p, Isy1p, Syf2p, Cwc2p, Prp46p, Clf1p, Cef1p, and Syf1p." [GOC:krc, PMID:16540691, PMID:19239890] synonym: "nineteen complex" NARROW [] synonym: "NTC" RELATED [] synonym: "Prp19/CDC5 complex" NARROW [] is_a: GO:0043234 ! protein complex created_by: kchris creation_date: 2009-10-12T10:01:30Z [Term] id: GO:0001100 name: negative regulation of exit from mitosis namespace: biological_process def: "Any process involved in the inhibition of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity)." [GOC:rn] synonym: "down regulation of exit from mitosis" EXACT [] synonym: "down-regulation of exit from mitosis" EXACT [] synonym: "downregulation of exit from mitosis" EXACT [] synonym: "inhibition of exit from mitosis" NARROW [] is_a: GO:0007096 ! regulation of exit from mitosis is_a: GO:0010948 ! negative regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010458 ! exit from mitosis relationship: negatively_regulates GO:0010458 ! exit from mitosis [Term] id: GO:0001101 name: response to acid namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acid stimulus." [GOC:rn] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0001300 name: chronological cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs when the cell is in a non-dividing, or quiescent, state." [GOC:jh, PMID:12044934] synonym: "chronological cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001301 name: progressive alteration of chromatin involved in cell aging namespace: biological_process def: "The chromatin modification process that occurs during the lifespan of the cell that results in changes in chromatin structure. Such changes may lead to gene dysregulation and ultimately to a loss in cell homeostasis, bringing about an aging phenotype." [GOC:jh, PMID:12044938] synonym: "age-dependent accumulation of genetic damage" RELATED [] synonym: "progressive alteration of chromatin during cell ageing" EXACT [] synonym: "progressive alteration of chromatin during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0016568 ! chromatin modification relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0001302 name: replicative cell aging namespace: biological_process def: "The process associated with progression of the cell from its inception to the end of its lifespan that occurs as the cell continues cycles of growth and division." [GOC:jh, PMID:12044934] synonym: "replicative cell ageing" EXACT [] is_a: GO:0007569 ! cell aging [Term] id: GO:0001303 name: nucleolar fragmentation involved in replicative aging namespace: biological_process def: "Process of enlargement and fragmentation of the nucleolus into multiple rounded structures that occurs in conjunction with increasing age in dividing cells." [GOC:jh, PMID:9891807] synonym: "nucleolar fragmentation during replicative ageing" RELATED [] synonym: "nucleolar fragmentation during replicative aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007576 ! nucleolar fragmentation relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001304 name: progressive alteration of chromatin involved in replicative cell aging namespace: biological_process def: "The process by which changes in chromatin structure contributing to replicative cell aging occurs." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during replicative cell ageing" EXACT [] synonym: "progressive alteration of chromatin during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001305 name: progressive alteration of chromatin involved in chronological cell aging namespace: biological_process def: "The process by which changes in chromatin structure contributing to chronological cell aging occur in non-dividing cells." [GOC:dph, GOC:jh, GOC:tb] synonym: "progressive alteration of chromatin during chronological cell ageing" RELATED [] synonym: "progressive alteration of chromatin during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001306 name: age-dependent response to oxidative stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] is_a: GO:0006979 ! response to oxidative stress is_a: GO:0007571 ! age-dependent general metabolic decline [Term] id: GO:0001307 name: extrachromosomal circular DNA accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh] synonym: "extrachromosomal circular DNA accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0007580 ! extrachromosomal circular DNA accumulation involved in cell aging [Term] id: GO:0001308 name: loss of chromatin silencing involved in replicative cell aging namespace: biological_process def: "The process, which occurs as a dividing cell ages, leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:jh, PMID:12044934] synonym: "loss of chromatin silencing during replicative cell ageing" RELATED [] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0006345 ! loss of chromatin silencing [Term] id: GO:0001309 name: age-dependent telomere shortening namespace: biological_process def: "Progressive reduction in length of the telomeres, the termini of eukaryotic chromosomes, that occurs as part of the cellular aging process." [GOC:jh, PMID:9891807] is_a: GO:0001304 ! progressive alteration of chromatin involved in replicative cell aging is_a: GO:0010834 ! telomere maintenance via telomere shortening [Term] id: GO:0001310 name: extrachromosomal rDNA circle accumulation involved in replicative cell aging namespace: biological_process def: "Increase in abundance of circular DNA molecules containing ribosomal DNA repeats in dividing cells as they age. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and then replicated independently of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "extrachromosomal rDNA circle accumulation during replicative cell ageing" RELATED [] synonym: "extrachromosomal rDNA circle accumulation during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "extrachromosomal ribosomal DNA circle accumulation during replicative cell aging" RELATED [] is_a: GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001311 name: formation of extrachromosomal circular rDNA by homologous recombination involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of DNA molecules encoding ribosomal RNA in dividing cells as they age." [GOC:jh, PMID:12044934] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular rDNA by homologous recombination during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "formation of extrachromosomal circular ribosomal DNA by homologous recombination during replicative cell aging" RELATED [] is_a: GO:0001313 ! formation of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001312 name: replication of extrachromosomal rDNA circles involved in replicative cell aging namespace: biological_process def: "Replication of rDNA following its excision from the chromosome of dividing cells as they age. Extrachromosomal rDNA forms a circle that contains at least one autonomously replicating sequence (ARS), which supports replication independent of chromosomal replication." [GOC:jh, PMID:12044934] synonym: "replication of extrachromosomal rDNA circles during replicative cell ageing" RELATED [] synonym: "replication of extrachromosomal rDNA circles during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "replication of extrachromosomal ribosomal DNA circles during replicative cell aging" RELATED [] is_a: GO:0001314 ! replication of extrachromosomal circular DNA involved in replicative cell aging relationship: part_of GO:0001310 ! extrachromosomal rDNA circle accumulation involved in replicative cell aging [Term] id: GO:0001313 name: formation of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats, in dividing cells as they age." [GOC:jh] synonym: "formation of extrachromosomal circular DNA during replicative cell ageing" RELATED [] synonym: "formation of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001325 ! formation of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001314 name: replication of extrachromosomal circular DNA involved in replicative cell aging namespace: biological_process def: "Replication of circular DNA following excision from the chromosome of dividing cells as they age; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] synonym: "replication of extrachromosomal circular DNA during replicative cell ageing" EXACT [] synonym: "replication of extrachromosomal circular DNA during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001326 ! replication of extrachromosomal circular DNA relationship: part_of GO:0001307 ! extrachromosomal circular DNA accumulation involved in replicative cell aging [Term] id: GO:0001315 name: age-dependent response to reactive oxygen species namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh, PMID:12044938] subset: gosubset_prok synonym: "age-dependent response to active oxygen species" EXACT [] synonym: "age-dependent response to AOS" EXACT [] synonym: "age-dependent response to reactive oxidative species" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate" EXACT [] synonym: "age-dependent response to ROI" EXACT [] synonym: "age-dependent response to ROS" EXACT [] is_a: GO:0000302 ! response to reactive oxygen species [Term] id: GO:0001316 name: age-dependent response to reactive oxygen species involved in replicative cell aging namespace: biological_process def: "A change in state or activity of a cell or an organism occurring during the process of replicative cell aging as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during replicative cell aging" RELATED [] synonym: "age-dependent response to AOS during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxidative species during replicative cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during replicative cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during replicative cell ageing" EXACT [] synonym: "age-dependent response to reactive oxygen species during replicative cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during replicative cell aging" RELATED [] synonym: "age-dependent response to ROS during replicative cell aging" RELATED [] is_a: GO:0001315 ! age-dependent response to reactive oxygen species is_a: GO:0001322 ! age-dependent response to oxidative stress involved in replicative cell aging [Term] id: GO:0001317 name: accumulation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Accumulation of proteins that have undergone reactions with reactive oxygen species in aging dividing cells and exhibit modifications such as increased protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "accumulation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "accumulation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001316 ! age-dependent response to reactive oxygen species involved in replicative cell aging [Term] id: GO:0001318 name: formation of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Chemical reaction, between proteins and reactive oxygen species, that occurs in dividing cells as they age and leads to a variety of changes in the affected proteins, including increases in protein carbonyl content, oxidized methionine, protein hydrophobicity, and cross-linking." [GOC:jh] synonym: "formation of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "formation of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0043687 ! post-translational protein modification relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001319 name: inheritance of oxidatively modified proteins involved in replicative cell aging namespace: biological_process def: "Process by which progeny cells acquire, or are barred from acquiring, proteins that have been altered by reaction with reactive oxygen species in dividing aging cells." [GOC:jh] synonym: "inheritance of oxidatively modified proteins during replicative cell ageing" RELATED [] synonym: "inheritance of oxidatively modified proteins during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0001317 ! accumulation of oxidatively modified proteins involved in replicative cell aging [Term] id: GO:0001320 name: age-dependent response to reactive oxygen species involved in chronological cell aging namespace: biological_process def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of reactive oxygen species, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to active oxygen species during chronological cell aging" RELATED [] synonym: "age-dependent response to AOS during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxidative species during chronological cell aging" EXACT [] synonym: "age-dependent response to reactive oxygen intermediate during chronological cell aging" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell ageing" RELATED [] synonym: "age-dependent response to reactive oxygen species during chronological cell aging" RELATED [GOC:dph, GOC:tb] synonym: "age-dependent response to ROI during chronological cell aging" RELATED [] synonym: "age-dependent response to ROS during chronological cell aging" RELATED [] is_a: GO:0001315 ! age-dependent response to reactive oxygen species is_a: GO:0001324 ! age-dependent response to oxidative stress involved in chronological cell aging [Term] id: GO:0001321 name: age-dependent general metabolic decline involved in replicative cell aging namespace: biological_process def: "The process, arising in dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh] synonym: "age-dependent general metabolic decline during replicative cell ageing" RELATED [] synonym: "age-dependent general metabolic decline involved in replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001302 ! replicative cell aging [Term] id: GO:0001322 name: age-dependent response to oxidative stress involved in replicative cell aging namespace: biological_process def: "A change in state or activity of a cell or an organism occurring in dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during replicative cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during replicative cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0001321 ! age-dependent general metabolic decline involved in replicative cell aging [Term] id: GO:0001323 name: age-dependent general metabolic decline involved in chronological cell aging namespace: biological_process def: "The process, arising in non-dividing cells as they age, that alters cellular metabolism and thus causes a decline in cell function." [GOC:jh] synonym: "age-dependent general metabolic decline during chronological cell ageing" RELATED [] synonym: "age-dependent general metabolic decline during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0007571 ! age-dependent general metabolic decline relationship: part_of GO:0001300 ! chronological cell aging [Term] id: GO:0001324 name: age-dependent response to oxidative stress involved in chronological cell aging namespace: biological_process def: "A change in state or activity of a cell or an organism occurring in non-dividing cells as they age as a result of oxidative stress, where the change varies according to the age of the cell or organism." [GOC:jh] synonym: "age-dependent response to oxidative stress during chronological cell ageing" RELATED [] synonym: "age-dependent response to oxidative stress during chronological cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001306 ! age-dependent response to oxidative stress is_a: GO:0001323 ! age-dependent general metabolic decline involved in chronological cell aging [Term] id: GO:0001325 name: formation of extrachromosomal circular DNA namespace: biological_process def: "Excision from the chromosome and circularization of a region of chromosomal DNA, generally, but not always, via homologous recombination between direct tandem repeats." [GOC:jh, PMID:12044938] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process is_a: GO:0022607 ! cellular component assembly [Term] id: GO:0001326 name: replication of extrachromosomal circular DNA namespace: biological_process def: "Replication of circular DNA following excision from the chromosome; replication of extrachromosomal circular DNA generally occurs independently of chromosomal replication." [GOC:jh] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0001400 name: mating projection base namespace: cellular_component def: "The region where the mating projection meets the bulk of the cell, in unicellular fungi exposed to mating pheromone." [GOC:mcc] synonym: "base of shmoo tip" NARROW [] synonym: "conjugation tube base" NARROW [] is_a: GO:0044463 ! cell projection part relationship: part_of GO:0005937 ! mating projection [Term] id: GO:0001401 name: mitochondrial sorting and assembly machinery complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates sorting of some imported proteins to the outer membrane and their assembly in the membrane; functions after import of incoming proteins by the mitochondrial outer membrane translocase complex." [PMID:12891361] comment: See also the cellular component term 'mitochondrial outer membrane translocase complex ; GO:0005742'. synonym: "SAM complex" EXACT [] synonym: "TOB complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0001402 name: signal transduction involved in filamentous growth namespace: biological_process def: "Relaying of environmental signals promoting filamentous growth." [GOC:mcc, PMID:9728395] synonym: "MAPKKK cascade (pseudohyphal growth)" RELATED [] synonym: "signal transduction during filamentous growth" RELATED [GOC:dph, GOC:tb] is_a: GO:0007165 ! signal transduction relationship: part_of GO:0030447 ! filamentous growth [Term] id: GO:0001403 name: invasive growth in response to glucose limitation namespace: biological_process def: "A growth pattern exhibited by budding haploid cells under certain growth conditions, in which cells retain the typical axial budding pattern of haploids, but become elongated and fail to separate after division; during growth on a solid substrate, this results in penetration of cells into the agar medium. An example of this process is found in Saccharomyces cerevisiae." [GOC:mcc, PMID:9728395] comment: Note that this term should not be used to describe the invasion of host tissues by pathogenic organisms, which is described by the biological process term 'invasive growth', nor should it be used to describe growth of diseased cells of an organism into the surrounding normal tissue, which is outside of the scope of GO. synonym: "colony morphology" RELATED [] is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0001404 name: invasive growth namespace: biological_process def: "OBSOLETE. Growth of a pathogenic organism that results in penetration into cells or tissues of the host organism. This often (but not necessarily) includes a filamentous growth form, and also can include secretion of proteases and lipases to break down host tissue." [GOC:mcc, PMID:9728395] comment: This term was made obsolete because more appropriate terms were created. synonym: "tissue invasion" EXACT [] is_obsolete: true consider: GO:0044409 [Term] id: GO:0001405 name: presequence translocase-associated import motor namespace: cellular_component def: "Protein complex located on the matrix side of the mitochondrial inner membrane and associated with the presequence translocase complex; hydrolyzes ATP to provide the force to drive import of proteins into the mitochondrial matrix." [GOC:mcc, PMID:14517234, PMID:14638855] synonym: "mitochondrial import motor" EXACT [] synonym: "PAM complex" EXACT [] synonym: "pre-sequence translocase-associated import motor" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005744 ! mitochondrial inner membrane presequence translocase complex [Term] id: GO:0001406 name: glycerophosphodiester transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of glycerophosphodiesters from one side of a membrane to the other. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015605 ! organophosphate ester transmembrane transporter activity relationship: part_of GO:0001407 ! glycerophosphodiester transport [Term] id: GO:0001407 name: glycerophosphodiester transport namespace: biological_process def: "The directed movement of glycerophosphodiesters into, out of, within or between cells by means of some external agent such as a transporter or pore. Glycerophosphodiesters are small molecules composed of glycerol-3-phosphate and an alcohol, for example, glycerophosphoinositol." [GOC:mcc, PMID:12912892] is_a: GO:0015748 ! organophosphate ester transport [Term] id: GO:0001408 name: guanine nucleotide transport namespace: biological_process def: "The directed movement of guanine nucleotides, GTP, GDP, and/or GMP, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:mcc] is_a: GO:0015865 ! purine nucleotide transport [Term] id: GO:0001409 name: guanine nucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of guanine nucleotides (GMP, GDP, and GTP) from one side of the membrane to the other." [GOC:mcc] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity relationship: part_of GO:0001408 ! guanine nucleotide transport [Term] id: GO:0001410 name: chlamydospore formation namespace: biological_process alt_id: GO:0055027 def: "The process whose specific outcome is the progression of the chlamydospore over time, from its formation to the mature structure. A chlamydospores is a mitotic (asexual) one-celled spore, produced primarily for survival, not dispersal, originating endogenously and singly within part of a pre-existing cell and possessing an inner secondary and often thickened cell wall. An example of this is found in Candida albicans." [GOC:mcc, GOC:mtg_sensu, ISBN:085199377X, PMID:14663094] synonym: "chlamydospore development" EXACT [] is_a: GO:0043936 ! asexual sporulation resulting in formation of a cellular spore is_a: GO:0048468 ! cell development [Term] id: GO:0001411 name: hyphal tip namespace: cellular_component def: "The end, or tip, of a fungal hypha, where polarized growth occurs during hyphal elongation." [GOC:mcc] subset: goslim_candida is_a: GO:0030427 ! site of polarized growth [Term] id: GO:0001501 name: skeletal system development namespace: biological_process def: "The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton)." [GOC:dph, GOC:jid, GOC:tb, http://www.stedmans.com/] synonym: "skeletal development" EXACT [] is_a: GO:0048731 ! system development [Term] id: GO:0001502 name: cartilage condensation namespace: biological_process def: "The condensation of mesenchymal cells that have been committed to differentiate into chondrocytes." [ISBN:0878932437] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0048705 ! skeletal system morphogenesis relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0001503 name: ossification namespace: biological_process def: "The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance." [GOC:mtg_mpo, http://cancerweb.ncl.ac.uk/] synonym: "bone biosynthesis" EXACT [] synonym: "bone formation" EXACT [] synonym: "osteogenesis" EXACT [] xref: Wikipedia:Ossification is_a: GO:0032502 ! developmental process relationship: part_of GO:0060348 ! bone development [Term] id: GO:0001504 name: neurotransmitter uptake namespace: biological_process def: "The directed movement of neurotransmitters into neurons or glial cells. This process leads to inactivation and recycling of neurotransmitters. It does not occur during cholinergic synaptic transmission. Instead, acetylcholine is enzymatically degraded in the synaptic cleft." [ISBN:0123668387] synonym: "neurotransmitter import" EXACT [GOC:dph, GOC:tb] synonym: "neurotransmitter import into glial cell" NARROW [] synonym: "neurotransmitter import into neuron" NARROW [] synonym: "neurotransmitter recycling" BROAD [] synonym: "neurotransmitter reuptake" EXACT [] xref: Reactome:112313 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:563219 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:588824 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:609549 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:634255 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:645736 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:656063 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:661243 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:667014 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:673159 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:678858 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:683787 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:690013 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:701782 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:716357 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:720840 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:735656 "Neurotransmitter uptake and Metabolism In Glial Cells" xref: Reactome:738572 "Neurotransmitter uptake and Metabolism In Glial Cells" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport [Term] id: GO:0001505 name: regulation of neurotransmitter levels namespace: biological_process def: "Any process that modulates levels of neurotransmitter." [GOC:jl] is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0007268 ! synaptic transmission [Term] id: GO:0001506 name: neurotransmitter biosynthetic process and storage namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of neurotransmitters and the storage of the synthesized molecules." [GOC:go_curators, ISBN:0123668387] comment: This term was made obsolete because it is an amalgamation of its two children. synonym: "neurotransmitter anabolism and storage" EXACT [] synonym: "neurotransmitter formation and storage" EXACT [] synonym: "neurotransmitter synthesis and storage" EXACT [] is_obsolete: true consider: GO:0042136 consider: GO:0042137 [Term] id: GO:0001507 name: acetylcholine catabolic process in synaptic cleft namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine that occurs in the synaptic cleft during synaptic transmission." [GOC:ai] synonym: "acetylcholine breakdown in synaptic cleft" EXACT [] synonym: "acetylcholine degradation in synaptic cleft" EXACT [] is_a: GO:0006581 ! acetylcholine catabolic process relationship: part_of GO:0007271 ! synaptic transmission, cholinergic [Term] id: GO:0001508 name: regulation of action potential namespace: biological_process def: "Any process that modulates the frequency, rate or extent of action potential creation, propagation or termination. An action potential is a spike of membrane depolarization and repolarization that travels along the membrane of a cell." [GOC:dph, GOC:go_curators, GOC:tb] is_a: GO:0042391 ! regulation of membrane potential [Term] id: GO:0001509 name: legumain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins and small-molecule substrates at Asn-Xaa bonds." [EC:3.4.22.34] comment: This term was made obsolete because it represents a gene product. synonym: "asparaginyl endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "bean endopeptidase activity" RELATED [EC:3.4.22.34] synonym: "citvac" RELATED [EC:3.4.22.34] synonym: "hemoglobinase activity" RELATED [EC:3.4.22.34] synonym: "phaseolin activity" RELATED [EC:3.4.22.34] synonym: "proteinase B" RELATED [EC:3.4.22.34] synonym: "PRSC1 gene product (Homo sapiens)" RELATED [EC:3.4.22.34] synonym: "vicilin peptidohydrolase activity" RELATED [EC:3.4.22.34] xref: EC:3.4.22.34 xref: MetaCyc:3.4.22.34-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0001510 name: RNA methylation namespace: biological_process def: "Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor." [GOC:hjd] subset: gosubset_prok is_a: GO:0009451 ! RNA modification is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0001511 name: fibrillin namespace: molecular_function def: "OBSOLETE. Large glycoprotein that is a calcium binding component of connective tissue microfibrils containing 34 six-cysteine (EGF-like) repeats and five eight-cysteine (TGFbeta-1 binding protein-like) repeats. Defects associated with Marfan syndrome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0001527 consider: GO:0005509 [Term] id: GO:0001512 name: dihydronicotinamide riboside quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide + a quinone = 1-(beta-D-ribofuranosyl)nicotinamide + a hydroquinone." [EC:1.10.99.2] synonym: "1-(beta-D-ribofuranosyl)-1,4-dihydronicotinamide:quinone oxidoreductase activity" EXACT [EC:1.10.99.2] synonym: "N-ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase 2 activity" EXACT [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase-2" RELATED [EC:1.10.99.2] synonym: "NAD(P)H:quinone oxidoreductase2" RELATED [EC:1.10.99.2] synonym: "NQO(2) activity" EXACT [EC:1.10.99.2] synonym: "NQO2" RELATED [EC:1.10.99.2] synonym: "NRH:quinone oxidoreductase 2 activity" NARROW [EC:1.10.99.2] synonym: "QR2 activity" RELATED [EC:1.10.99.2] synonym: "quinone reductase 2 activity" RELATED [EC:1.10.99.2] synonym: "ribosyldihydronicotinamide dehydrogenase (quinone) activity" EXACT [] xref: EC:1.10.99.2 xref: MetaCyc:1.10.99.2-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0001514 name: selenocysteine incorporation namespace: biological_process def: "The incorporation of selenocysteine into a peptide; uses a special tRNA that recognizes the UGA codon as selenocysteine, rather than as a termination codon. Selenocysteine is synthesized from serine before its incorporation; it is not a posttranslational modification of peptidyl-cysteine." [RESID:AA0022] subset: gosubset_prok xref: RESID:AA0022 is_a: GO:0006451 ! translational readthrough [Term] id: GO:0001515 name: opioid peptide activity namespace: molecular_function def: "Naturally occurring peptide that is an opioid (any non-alkaloid having an opiate-like effect that can be reversed by naloxone or other recognized morphine antagonist). These include Leu- and Met-enkephalin, dynorphin and neoendorphin, alpha, beta, gamma and delta endorphins formed from beta-lipotropin, various pronase-resistant peptides such as beta casamorphin, and other peptides whose opiate-like action seems to be indirect." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005102 ! receptor binding [Term] id: GO:0001516 name: prostaglandin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring." [GOC:ai] subset: gosubset_prok synonym: "prostaglandin anabolism" EXACT [] synonym: "prostaglandin biosynthesis" EXACT [] synonym: "prostaglandin formation" EXACT [] synonym: "prostaglandin synthesis" EXACT [] is_a: GO:0006693 ! prostaglandin metabolic process is_a: GO:0046457 ! prostanoid biosynthetic process [Term] id: GO:0001517 name: N-acetylglucosamine 6-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-glucosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-glucosamine 6-sulfate." [GOC:ai, GOC:hjd] synonym: "N-acetylglucosamine 6-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001518 name: voltage-gated sodium channel complex namespace: cellular_component def: "A sodium channel in a cell membrane whose opening is governed by the membrane potential." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "voltage gated sodium channel complex" EXACT [] synonym: "voltage-dependent sodium channel complex" EXACT [] synonym: "voltage-sensitive sodium channel complex" EXACT [] xref: NIF_Subcellular:sao785001660 is_a: GO:0034706 ! sodium channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0001519 name: peptide amidation namespace: biological_process def: "The posttranslational conversion of C-terminal glycine-extended peptides to C-terminal alpha-amidated peptides. Occurs to over half of all peptide hormones to give bioactive peptides. This is a two step process catalyzed by a peptidyl-glycine alpha-hydroxylating monooxygenase and a peptidyl-alpha-hydroxyglycine alpha-amidating lyase. In some organisms, this process is catalyzed by two separate enzymes, whereas in higher organisms, one polypeptide catalyzes both reactions." [PMID:11028916] subset: gosubset_prok is_a: GO:0031179 ! peptide modification [Term] id: GO:0001520 name: outer dense fiber namespace: cellular_component def: "Structure or material found in the flagella of mammalian sperm that surrounds each of the nine microtubule doublets, giving a 9 + 9 + 2 arrangement rather than the 9 + 2 pattern usually seen. These dense fibers are stiff and noncontractile." [ISBN:0824072820] synonym: "outer dense fibre" EXACT [] is_a: GO:0044447 ! axoneme part [Term] id: GO:0001522 name: pseudouridine synthesis namespace: biological_process def: "The intramolecular conversion of uridine to pseudouridine within an RNA molecule. This posttranscriptional base modification occurs in tRNA, rRNA, and snRNAs." [GOC:hjd, GOC:mah] subset: gosubset_prok synonym: "pseudouridylation" EXACT [] xref: Wikipedia:Pseudouridine xref: Wikipedia:Pseudouridylation is_a: GO:0009451 ! RNA modification [Term] id: GO:0001523 name: retinoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "retinoid metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process [Term] id: GO:0001524 name: globin namespace: molecular_function def: "OBSOLETE. The colorless and basic protein moiety of hemoglobin and myoglobins." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0005344 [Term] id: GO:0001525 name: angiogenesis namespace: biological_process def: "Blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels." [ISBN:0878932453] synonym: "blood vessel formation from pre-existing blood vessels" EXACT systematic_synonym [] xref: Wikipedia:Angiogenesis is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001526 name: proteoglycan sulfate transfer namespace: biological_process def: "OBSOLETE. Transfer of sulfate to a proteoglycan (a glycoprotein whose carbohydrate units are glycosaminoglycans) using 3'-phosphoadenyl sulfate." [GOC:hjd] comment: This term was made obsolete because it represents a group of molecular functions. synonym: "proteoglycan sulphate transfer" EXACT [] is_obsolete: true consider: GO:0006029 consider: GO:0006790 consider: GO:0050698 [Term] id: GO:0001527 name: microfibril namespace: cellular_component def: "Extracellular matrix components occurring independently or along with elastin. Thought to have force-bearing functions in tendon. In addition to fibrillins, microfibrils may contain other associated proteins." [http://www.xrefer.com/entry/490235] synonym: "extended fibrils" EXACT [] synonym: "fibrillin" RELATED [] is_a: GO:0043205 ! fibril [Term] id: GO:0001528 name: elastin namespace: molecular_function def: "OBSOLETE. A major structural protein of mammalian connective tissues; composed of one third glycine, and also rich in proline, alanine, and valine. Chains are cross-linked together via lysine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001529 name: elastin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030023 [Term] id: GO:0001530 name: lipopolysaccharide binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipopolysaccharide." [PMID:11079463] synonym: "endotoxin binding" BROAD [] synonym: "LPS binding" EXACT [] is_a: GO:0005488 ! binding [Term] id: GO:0001531 name: interleukin-21 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-21 receptor." [GOC:ai] synonym: "IL-21" NARROW [] synonym: "interleukin-21 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0001532 name: interleukin-21 receptor activity namespace: molecular_function def: "Combining with interleukin-21 to initiate a change in cell activity." [GOC:jl] synonym: "IL-21 receptor activity" EXACT [GOC:mah] synonym: "IL-21R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019977 ! interleukin-21 binding [Term] id: GO:0001533 name: cornified envelope namespace: cellular_component def: "An insoluble protein structure formed under the plasma membrane of cornifying epithelial cells." [PMID:11112355] is_a: GO:0005856 ! cytoskeleton [Term] id: GO:0001534 name: radial spoke namespace: cellular_component def: "Protein complex that links the outer microtubule doublet of the ciliary or flagellum axoneme with the sheath that surrounds the central pair of microtubules. Composed of a stalk that attaches to each doublet microtubule and a globular structure (spoke head) that projects toward the central pair of microtubules." [ISBN:0124325653, PMID:9450971] subset: goslim_pir xref: Wikipedia:Radial_spoke is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0001535 name: radial spokehead namespace: cellular_component def: "Protein complex forming part of eukaryotic flagellar apparatus." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001536 name: radial spoke stalk namespace: cellular_component def: "Globular portion of the radial spoke that projects towards the central pair of microtubules." [GOC:hjd] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part relationship: part_of GO:0001534 ! radial spoke [Term] id: GO:0001537 name: N-acetylgalactosamine 4-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + N-acetyl-D-galactosamine = adenosine 3',5'-bisphosphate + N-acetyl-D-galactosamine 4-sulfate." [EC:2.8.2.-, GOC:ai] synonym: "N-acetylgalactosamine 4-O-sulphotransferase activity" EXACT [] xref: EC:2.8.2.- is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0001539 name: ciliary or flagellar motility namespace: biological_process def: "Cell motility due to movement of cilia or flagella." [GOC:hjd] subset: gosubset_prok synonym: "ciliary/flagellar motility" EXACT [] is_a: GO:0048870 ! cell motility [Term] id: GO:0001540 name: beta-amyloid binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-amyloid peptide/protein and/or its precursor." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0001541 name: ovarian follicle development namespace: biological_process def: "The process whose specific outcome is the progression of the ovarian follicle over time, from its formation to the mature structure." [GOC:go_curators] synonym: "follicular phase" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001542 name: ovulation from ovarian follicle namespace: biological_process def: "The process leading to the rupture of the follicle, releasing the centrally located oocyte into the oviduct. An example of this is found in Mus musculus." [GOC:mtg_sensu, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process is_a: GO:0030728 ! ovulation relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001543 name: ovarian follicle rupture namespace: biological_process def: "Disruption of theca cell layer releasing follicular fluid and/or the oocyte." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001542 ! ovulation from ovarian follicle [Term] id: GO:0001544 name: initiation of primordial ovarian follicle growth namespace: biological_process def: "Increase in size of primordial follicles including proliferation and shape changes of granulosa and/or theca cells until oocyte is surrounded by one layer of cuboidal shaped granulosa cells (primary follicle)." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001545 name: primary ovarian follicle growth namespace: biological_process def: "Increase in size of primary follicles including oocyte growth and granulosa and/or theca cell proliferation until more than one layer of granulosa cells is present (preantral follicle)." [GOC:mtg_mpo, http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001546 name: preantral ovarian follicle growth namespace: biological_process def: "Increase in size of follicles surrounded by two or more layers of granulosa cells up to the onset of antrum formation." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development relationship: part_of GO:0048162 ! multi-layer follicle stage [Term] id: GO:0001547 name: antral ovarian follicle growth namespace: biological_process def: "Increase in size of antral follicles due to cell proliferation and/or growth of the antral cavity." [http://ovary.stanford.edu] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0022602 ! ovulation cycle process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001548 name: follicular fluid formation in ovarian follicle antrum namespace: biological_process def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed during the various stages of oogenesis." [GOC:dph, GOC:tb, http://ovary.stanford.edu] synonym: "ovarian follicle antrum/follicular fluid biosynthesis" EXACT [] synonym: "ovarian follicle antrum/follicular fluid formation" EXACT [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth [Term] id: GO:0001549 name: cumulus cell differentiation namespace: biological_process def: "The process whereby a subpopulation of granulosa cells surrounding the oocyte acquires the specialized features of an ovarian cumulus cell." [http://ovary.stanford.edu] synonym: "ovarian cumulus cell differentiation" EXACT [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001550 name: ovarian cumulus expansion namespace: biological_process def: "Increase in size of the cumulus surrounding the oocyte including change in morphology due to proliferation and dispersion of cumulus cells." [http://ovary.stanford.edu] synonym: "ovarian cumulus growth" RELATED [] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001547 ! antral ovarian follicle growth relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0001551 name: ovarian follicle endowment namespace: biological_process def: "Association of oocytes with supporting epithelial granulosa cells to form primordial follicles." [http://ovary.stanford.edu] is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0001541 ! ovarian follicle development [Term] id: GO:0001552 name: ovarian follicle atresia namespace: biological_process def: "Ovarian follicle demise mediated by apoptosis." [http://ovary.stanford.edu] is_a: GO:0006915 ! apoptosis is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001553 name: luteinization namespace: biological_process def: "The set of processes resulting in differentiation of theca and granulosa cells into luteal cells and in the formation of a corpus luteum after ovulation." [http://ovary.stanford.edu] synonym: "luteal phase" RELATED [] xref: Wikipedia:Luteal_phase xref: Wikipedia:Luteinization is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001554 name: luteolysis namespace: biological_process def: "Regression of ovarian corpora lutea." [http://ovary.stanford.edu] xref: Wikipedia:Luteolysis is_a: GO:0022602 ! ovulation cycle process relationship: part_of GO:0008585 ! female gonad development [Term] id: GO:0001555 name: oocyte growth namespace: biological_process def: "The process by which an oocyte irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [http://ovary.stanford.edu] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048601 ! oocyte morphogenesis [Term] id: GO:0001556 name: oocyte maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for an oocyte to attain its fully functional state. Oocyte maturation commences after reinitiation of meiosis commonly starting with germinal vesicle breakdown, and continues up to the second meiotic arrest prior to fertilization." [GOC:devbiol, http://ovary.stanford.edu] xref: Wikipedia:Oocyte_maturation is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048469 ! cell maturation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0001557 name: metabolic process resulting in cell growth namespace: biological_process def: "OBSOLETE. The chemical reactions that occur in living organisms that result in an increase in the mass (size) of a cell." [GOC:dph] comment: This term was made obsolete as part of the metabolism rearrangements, because it is redundant with other terms. is_obsolete: true replaced_by: GO:0008152 replaced_by: GO:0016049 [Term] id: GO:0001558 name: regulation of cell growth namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell growth." [GOC:go_curators] subset: gosubset_prok xref: Reactome:110498 "DTOR is positively regulated by DRheb-GTP" is_a: GO:0040008 ! regulation of growth is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016049 ! cell growth relationship: regulates GO:0016049 ! cell growth [Term] id: GO:0001559 name: regulation of cell growth by detection of nuclear:cytoplasmic ratio namespace: biological_process def: "Any process whereby the size of the nucleus with respect to the cytoplasm modulates the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "detection of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "interpretation of nuclear:cytoplasmic ratio to regulate cell growth" EXACT [] synonym: "regulation of cell growth by nuclear:cytoplasmic ratio" EXACT [] synonym: "regulation of cell growth by sensing of nuclear:cytoplasmic ratio" EXACT [] is_a: GO:0001558 ! regulation of cell growth is_a: GO:0016475 ! detection of nuclear:cytoplasmic ratio [Term] id: GO:0001560 name: regulation of cell growth by extracellular stimulus namespace: biological_process def: "Any process whereby external signals modulate the frequency, rate or extent of cell growth, the irreversible increase in size of a cell over time." [GOC:dph] synonym: "interpretation of external signals that regulate cell growth" EXACT [] synonym: "regulation of cell growth by detection of exogenous stimulus" EXACT [] synonym: "regulation of cell growth by sensing of exogenous stimulus" EXACT [] synonym: "regulation of growth by exogenous signal" EXACT [] synonym: "regulation of growth by exogenous stimuli" EXACT [] synonym: "regulation of growth by exogenous stimulus" EXACT [] synonym: "regulation of growth by external signal" EXACT [] synonym: "regulation of growth by external stimuli" EXACT [] synonym: "regulation of growth by external stimulus" EXACT [] is_a: GO:0001558 ! regulation of cell growth relationship: part_of GO:0031668 ! cellular response to extracellular stimulus [Term] id: GO:0001561 name: fatty acid alpha-oxidation namespace: biological_process def: "A metabolic pathway by which 3-methyl branched fatty acids are degraded. These compounds are not degraded by the normal peroxisomal beta-oxidation pathway, because the 3-methyl blocks the dehydrogenation of the hydroxyl group by hydroxyacyl-CoA dehydrogenase. The 3-methyl branched fatty acid is converted in several steps to pristenic acid, which can then feed into the beta-oxidative pathway." [http://www.peroxisome.org/Scientist/Biochemistry/alpha-oxidation.html] subset: gosubset_prok xref: MetaCyc:PWY-2501 xref: Reactome:389599 "Alpha-oxidation of phytanate" xref: Reactome:562594 "Alpha-oxidation of phytanate" xref: Reactome:588220 "Alpha-oxidation of phytanate" xref: Reactome:608981 "Alpha-oxidation of phytanate" xref: Reactome:633663 "Alpha-oxidation of phytanate" xref: Reactome:645283 "Alpha-oxidation of phytanate" xref: Reactome:655660 "Alpha-oxidation of phytanate" xref: Reactome:660942 "Alpha-oxidation of phytanate" xref: Reactome:666716 "Alpha-oxidation of phytanate" xref: Reactome:672813 "Alpha-oxidation of phytanate" xref: Reactome:678536 "Alpha-oxidation of phytanate" xref: Reactome:683492 "Alpha-oxidation of phytanate" xref: Reactome:689695 "Alpha-oxidation of phytanate" xref: Reactome:701432 "Alpha-oxidation of phytanate" xref: Reactome:716003 "Alpha-oxidation of phytanate" xref: Reactome:727952 "Alpha-oxidation of phytanate" xref: Reactome:731134 "Alpha-oxidation of phytanate" xref: Reactome:732999 "Alpha-oxidation of phytanate" xref: Reactome:733844 "Alpha-oxidation of phytanate" xref: Reactome:735562 "Alpha-oxidation of phytanate" xref: Reactome:736533 "Alpha-oxidation of phytanate" xref: Reactome:738471 "Alpha-oxidation of phytanate" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0001562 name: response to protozoan namespace: biological_process alt_id: GO:0042833 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a protozoan." [GOC:ai] synonym: "resistance to pathogenic protozoa" RELATED [] synonym: "response to protozoa" EXACT [] synonym: "response to protozoon" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0001563 name: detection of protozoan namespace: biological_process def: "The series of events in which a stimulus from a protozoan is received and converted into a molecular signal." [GOC:ai] synonym: "detection of protozoa" EXACT [] synonym: "detection of protozoon" EXACT [] synonym: "perception of protozoa" RELATED [] is_a: GO:0001562 ! response to protozoan is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0001564 name: resistance to pathogenic protozoa namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0001562 [Term] id: GO:0001565 name: phorbol ester receptor activity namespace: molecular_function def: "Combining with a phorbol ester to initiate a change in cell activity." [GOC:ai, PMID:10506570] is_a: GO:0004872 ! receptor activity [Term] id: GO:0001566 name: non-kinase phorbol ester receptor activity namespace: molecular_function def: "Phorbol ester/diacylglycerol binding proteins that do not have intrinsic kinase activity." [PMID:10506570] is_a: GO:0001565 ! phorbol ester receptor activity [Term] id: GO:0001567 name: cholesterol 25-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + AH2 + O2 = 25-hydroxycholesterol + A + H2O." [EC:1.14.99.38] synonym: "cholesterol 25-monooxygenase activity" EXACT [EC:1.14.99.38] synonym: "cholesterol,hydrogen-donor:oxygen oxidoreductase (25-hydroxylating) activity" EXACT [EC:1.14.99.38] xref: EC:1.14.99.38 xref: MetaCyc:1.14.99.38-RXN is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0001568 name: blood vessel development namespace: biological_process def: "The process whose specific outcome is the progression of a blood vessel over time, from its formation to the mature structure. The blood vessel is the vasculature carrying blood." [GOC:hjd] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001569 name: patterning of blood vessels namespace: biological_process def: "The process that regulates the coordinated growth and sprouting of blood vessels giving rise to the organized vascular system." [GOC:dph] synonym: "branching involved in blood vessel morphogenesis" EXACT [GOC:dph] is_a: GO:0007389 ! pattern specification process is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0001525 ! angiogenesis [Term] id: GO:0001570 name: vasculogenesis namespace: biological_process def: "The differentiation of endothelial cells from progenitor cells during blood vessel development, and the de novo formation of blood vessels and tubes." [PMID:8999798] synonym: "vascular morphogenesis" EXACT [] xref: Wikipedia:Vasculogenesis is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001571 name: non-tyrosine kinase fibroblast growth factor receptor activity namespace: molecular_function def: "A receptor belonging to the FGFR family but lacking the tyrosine kinase domain." [PMID:11418238] synonym: "non-tyrosine kinase FGF receptor activity" EXACT [] synonym: "non-tyrosine kinase FGFR activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0001572 name: lactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactosylceramides, Gal beta(1,4)Glc beta(1,1') ceramides, any compound formed by the replacement of the glycosidic C1 hydroxyl group of lactose by a ceramide group. They are the precursors of both gangliosides and globosides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471586501] subset: gosubset_prok synonym: "lactosylceramide anabolism" EXACT [] synonym: "lactosylceramide biosynthesis" EXACT [] synonym: "lactosylceramide formation" EXACT [] synonym: "lactosylceramide synthesis" EXACT [] is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process is_a: GO:0046478 ! lactosylceramide metabolic process [Term] id: GO:0001573 name: ganglioside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ganglioside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001574 name: ganglioside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ceramide oligosaccharides carrying in addition to other sugar residues, one or more sialic acid residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ganglioside anabolism" EXACT [] synonym: "ganglioside biosynthesis" EXACT [] synonym: "ganglioside formation" EXACT [] synonym: "ganglioside synthesis" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001575 name: globoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving globosides, globotetraosylceramides, ceramides containing a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I). Globosides are the major neutral glycosphingolipid in normal kidneys and erythrocytes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "globoside metabolism" EXACT [] is_a: GO:0006672 ! ceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0001576 name: globoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ceramide with a core structure of GalNAc-beta-(1,3)-Gal-alpha(1,4)Glc(I)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "globoside anabolism" EXACT [] synonym: "globoside biosynthesis" EXACT [] synonym: "globoside formation" EXACT [] synonym: "globoside synthesis" EXACT [] is_a: GO:0001575 ! globoside metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process [Term] id: GO:0001577 name: galectin namespace: molecular_function def: "OBSOLETE. A lectin that exhibits calcium independent binding of beta-galactoside sugars." [PMID:9786891] comment: This term was made obsolete because it refers to a class of gene products. synonym: "S-type lectin" EXACT [] is_obsolete: true consider: GO:0007157 consider: GO:0016936 [Term] id: GO:0001578 name: microtubule bundle formation namespace: biological_process def: "A process that results in a parallel arrangement of microtubules." [GOC:dph] synonym: "microtubule bundling" EXACT [] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0001579 name: medium-chain fatty acid transport namespace: biological_process def: "The directed movement of medium-chain fatty acids into, out of, within or between cells by means of some external agent such as a transporter or pore. Medium-chain fatty acids are fatty acids with a chain length of between 8 and 12 carbons." [GOC:ai] is_a: GO:0015908 ! fatty acid transport [Term] id: GO:0001580 name: detection of chemical stimulus involved in sensory perception of bitter taste namespace: biological_process def: "The series of events required for a bitter taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "bitter taste detection" EXACT [] synonym: "perception of bitter taste, detection of chemical stimulus" EXACT [] synonym: "perception of bitter taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of bitter taste" EXACT [] synonym: "sensory detection of chemical stimulus during perception of bitter taste" EXACT [] synonym: "sensory transduction of bitter taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of bitter taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050913 ! sensory perception of bitter taste [Term] id: GO:0001581 name: detection of chemical stimulus involved in sensory perception of sour taste namespace: biological_process def: "The series of events required for a sour taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sour taste, detection of chemical stimulus" EXACT [] synonym: "perception of sour taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory detection of sour taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sour taste" EXACT [] synonym: "sensory transduction of sour taste" EXACT [] synonym: "sour taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050915 ! sensory perception of sour taste [Term] id: GO:0001582 name: detection of chemical stimulus involved in sensory perception of sweet taste namespace: biological_process def: "The series of events required for a sweet taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of sweet taste, detection of chemical stimulus" EXACT [] synonym: "perception of sweet taste, sensory transduction of chemical stimulus" EXACT [] synonym: "sensory detection of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory detection of sweet taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of sweet taste" EXACT [] synonym: "sensory transduction of sweet taste" EXACT [] synonym: "sweet taste detection" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050916 ! sensory perception of sweet taste [Term] id: GO:0001583 name: detection of chemical stimulus involved in sensory perception of salty taste namespace: biological_process def: "The series of events required for a salty taste stimulus to be received and converted to a molecular signal." [GOC:go_curators] synonym: "perception of salty taste, detection of chemical stimulus" EXACT [] synonym: "perception of salty taste, sensory transduction of chemical stimulus" EXACT [] synonym: "salty taste detection" EXACT [] synonym: "sensory detection of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory detection of salty taste" EXACT [] synonym: "sensory transduction of chemical stimulus during perception of salty taste" EXACT [] synonym: "sensory transduction of salty taste" EXACT [] is_a: GO:0050912 ! detection of chemical stimulus involved in sensory perception of taste relationship: part_of GO:0050914 ! sensory perception of salty taste [Term] id: GO:0001584 name: rhodopsin-like receptor activity namespace: molecular_function alt_id: GO:0001620 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the rhodopsin receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1505] comment: This term was made obsolete because it represents a gene product and is named based on protein features. subset: gosubset_prok synonym: "Class A G protein coupled receptor" EXACT [] synonym: "Class A G-protein coupled receptor" EXACT [] synonym: "Class A GPCR" EXACT [] synonym: "class A orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001586 name: 5-HT1 receptor activity namespace: molecular_function is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001587 name: 5-HT2 receptor activity namespace: molecular_function is_a: GO:0004993 ! serotonin receptor activity [Term] id: GO:0001588 name: dopamine receptor activity, coupled via Gs namespace: molecular_function def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gs to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] is_a: GO:0004952 ! dopamine receptor activity [Term] id: GO:0001589 name: dopamine D5 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D5 receptors." [IUPHAR_RECEPTOR:2260] is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs [Term] id: GO:0001590 name: dopamine D1 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D1 receptors." [IUPHAR_RECEPTOR:2252] is_a: GO:0001588 ! dopamine receptor activity, coupled via Gs [Term] id: GO:0001591 name: dopamine receptor activity, coupled via Gi/Go namespace: molecular_function def: "Combining with the neurotransmitter dopamine and activating adenylate cyclase via coupling to Gi/Go to initiate a change in cell activity." [GOC:mah, ISBN:0953351033] is_a: GO:0004952 ! dopamine receptor activity [Term] id: GO:0001592 name: dopamine D3 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D3 receptors." [IUPHAR_RECEPTOR:2256] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001593 name: dopamine D4 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D4 receptors." [IUPHAR_RECEPTOR:2258] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001594 name: trace-amine receptor activity namespace: molecular_function is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0001595 name: angiotensin receptor activity namespace: molecular_function def: "Combining with angiotensin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001596 name: angiotensin type I receptor activity namespace: molecular_function is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0001597 name: apelin-like receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because the function it represents does not exist. synonym: "APJ-like receptor" EXACT [] is_obsolete: true consider: GO:0031704 [Term] id: GO:0001598 name: chemokine receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001599 name: endothelin-A receptor activity namespace: molecular_function def: "A G-protein coupled receptor that preferentially binds endothelin 1." [IUPHAR_RECEPTOR:2263, PMID:8582288] is_a: GO:0004962 ! endothelin receptor activity [Term] id: GO:0001600 name: endothelin-B receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds all endothelin molecules with approximately equal affinity." [IUPHAR_RECEPTOR:2265, PMID:8582288] is_a: GO:0004962 ! endothelin receptor activity [Term] id: GO:0001601 name: peptide YY receptor activity namespace: molecular_function def: "Combining with gut peptide YY to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001602 name: pancreatic polypeptide receptor activity namespace: molecular_function def: "Combining with pancreatic polypeptide PP to initiate a change in cell activity." [PMID:9315606] is_a: GO:0004983 ! neuropeptide Y receptor activity [Term] id: GO:0001603 name: vasopressin-like receptor activity namespace: molecular_function is_obsolete: true [Term] id: GO:0001604 name: urotensin II receptor activity namespace: molecular_function is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001605 name: adrenomedullin receptor activity namespace: molecular_function def: "Combining with adrenomedullin to initiate a change in cell activity." [GOC:ai] synonym: "G10D receptor" NARROW [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001606 name: GPR37/endothelin B-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001607 name: neuromedin U receptor activity namespace: molecular_function def: "Combining with neuromedin U to initiate a change in cell activity." [GOC:ai] synonym: "NMUR activity" EXACT [] is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0042924 ! neuromedin U binding [Term] id: GO:0001608 name: nucleotide receptor activity, G-protein coupled namespace: molecular_function def: "A GPCR that binds a nucleotide or nucleotide derivative as its ligand." [GOC:dph, IUPHAR_GPCR:1294] synonym: "G protein coupled nucleotide receptor activity" EXACT [] synonym: "G-protein-coupled nucleotide receptor activity" EXACT [] synonym: "nucleotide receptor activity, G protein coupled" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001609 name: adenosine receptor activity, G-protein coupled namespace: molecular_function alt_id: GO:0001610 alt_id: GO:0001611 alt_id: GO:0001612 alt_id: GO:0001613 alt_id: GO:0008501 def: "Combining with adenosine and transmitting the signal to a heterotrimeric G-protein complex to initiate a change in cell activity." [GOC:mah, PMID:9755289] synonym: "A1 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A1 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2A adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G protein coupled" NARROW [] synonym: "A2B adenosine receptor activity, G-protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G protein coupled" NARROW [] synonym: "A3 adenosine receptor activity, G-protein coupled" NARROW [] synonym: "adenosine nucleotide receptor" BROAD [] synonym: "adenosine receptor activity, G protein coupled" EXACT [] synonym: "G protein coupled A1 adenosine receptor activity" NARROW [] synonym: "G protein coupled A2A adenosine receptor activity" NARROW [] synonym: "G protein coupled A2B adenosine receptor activity" NARROW [] synonym: "G protein coupled A3 adenosine receptor activity" NARROW [] synonym: "G protein coupled adenosine receptor activity" EXACT [] synonym: "G-protein-coupled A1 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2A adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A2B adenosine receptor activity" NARROW [] synonym: "G-protein-coupled A3 adenosine receptor activity" NARROW [] synonym: "G-protein-coupled adenosine receptor activity" EXACT [] xref: Reactome:71 "adenosine receptor activity, G-protein coupled" is_a: GO:0045028 ! purinergic nucleotide receptor activity, G-protein coupled [Term] id: GO:0001614 name: purinergic nucleotide receptor activity namespace: molecular_function def: "Combining with a purine nucleotide to initiate a change in cell activity." [GOC:mah] synonym: "P2Y receptor" NARROW [] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] is_a: GO:0016502 ! nucleotide receptor activity [Term] id: GO:0001615 name: thyrotropin releasing hormone and secretagogue-like receptors activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001616 name: growth hormone secretagogue receptor activity namespace: molecular_function is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001617 name: growth hormone secretagogue-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001618 name: viral receptor activity namespace: molecular_function def: "Combining with a virus component to initiate a change in cell activity." [GOC:dph] is_a: GO:0004872 ! receptor activity [Term] id: GO:0001619 name: lysosphingolipid and lysophosphatidic acid receptor activity namespace: molecular_function def: "Combining with lysosphingolipid or lysophosphatidic acid to initiate a change in cell activity." [GOC:dph] is_a: GO:0045125 ! bioactive lipid receptor activity [Term] id: GO:0001621 name: platelet ADP receptor activity namespace: molecular_function synonym: "K101 receptor" NARROW [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001622 name: super conserved receptor expressed in brain receptor activity namespace: molecular_function synonym: "SREB receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001623 name: Mas proto-oncogene receptor activity namespace: molecular_function is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001624 name: RDC1 receptor activity namespace: molecular_function is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001625 name: Epstein-Barr Virus-induced receptor activity namespace: molecular_function synonym: "EBV-induced receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001626 name: nociceptin/orphanin-FQ receptor activity namespace: molecular_function synonym: "ORPH receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001627 name: leucine-rich G-protein receptor-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "leucine-rich G protein receptor-like receptor activity" EXACT [] synonym: "LGR-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001628 name: gastropyloric receptor activity namespace: molecular_function synonym: "GPR receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001629 name: G-protein receptor 45-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. synonym: "G protein receptor 45-like receptor activity" EXACT [] synonym: "GPR45-like receptor" EXACT [] is_obsolete: true [Term] id: GO:0001630 name: GP40-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001631 name: cysteinyl leukotriene receptor activity namespace: molecular_function def: "Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "CysLT receptor" EXACT [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001632 name: leukotriene B4 receptor activity namespace: molecular_function def: "Combining with leukotriene B4, LTB4, to initiate a change in cell activity. Leukotriene B4 is also known as (6Z, 8E, 10E, 14Z)-(5S, 12R)-5,12-dihydroxyicosa-6,8,10,14-tetraen-1-oate." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "BLT receptor" NARROW [] is_a: GO:0004974 ! leukotriene receptor activity [Term] id: GO:0001633 name: secretin-like receptor activity namespace: molecular_function alt_id: GO:0001638 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the secretin receptor." [GOC:mah, IUPHAR_GPCR:1506] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class B G protein coupled receptor" EXACT [] synonym: "class B G-protein coupled receptor" EXACT [] synonym: "class B GPCR" EXACT [] synonym: "class B orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0001634 name: pituitary adenylate cyclase-activating polypeptide receptor activity namespace: molecular_function alt_id: GO:0016522 def: "A G-protein coupled receptor that interacts with pituitary adenylate cyclase-activating polypeptide." [GOC:dph, GOC:tb] synonym: "PACAP receptor" EXACT [] synonym: "pituitary adenylate cyclase activating polypeptide receptor" EXACT [] synonym: "pituitary adenylate cyclase activating protein receptor activity" EXACT [GOC:dph, GOC:tb] synonym: "pituitary adenylate cyclase-activating peptide receptor activity" RELATED [] synonym: "pituitary adenylate cyclase-activating polypeptide receptor activity" RELATED [] synonym: "pituitary adenylyl cyclase activating protein receptor activity" EXACT [] xref: Reactome:272 "pituitary adenylate cyclase-activating polypeptide receptor activity" is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001635 name: calcitonin gene-related polypeptide receptor activity namespace: molecular_function synonym: "CGRP receptor" EXACT [] xref: Wikipedia:CALCRL is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0001636 name: corticotrophin-releasing factor gastric inhibitory peptide-like receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, was not defined, and is named based on protein features. is_obsolete: true [Term] id: GO:0001637 name: G-protein chemoattractant receptor activity namespace: molecular_function synonym: "G protein chemoattractant receptor activity" EXACT [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001639 name: PLC activating metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and is linked to the inositol 1,4,5-trisphosphate/calcium signaling system." [PMID:9016303] synonym: "Group I metabotropic glutamate receptor" RELATED [] synonym: "group I metabotropic glutamate receptor activity" RELATED [] synonym: "phospholipase C activating metabotropic glutamate receptor activity" EXACT [] is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0001640 name: adenylate cyclase inhibiting metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds glutamate and inhibits adenylate cyclase activity." [GOC:dph] synonym: "adenylyl cyclase inhibiting metabotropic glutamate receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0008066 ! glutamate receptor activity relationship: part_of GO:0007196 ! inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway [Term] id: GO:0001641 name: group II metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by trans-1-aminocyclopentane-1,3-dicarboxylic acid (t-ACPD) and inhibits adenylate cyclase activity." [GOC:dph] is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: GO:0001642 name: group III metabotropic glutamate receptor activity namespace: molecular_function def: "A G-protein coupled receptor that is activated by L-AP-4 and inhibits adenylate cyclase activity." [PMID:9016303] is_a: GO:0001640 ! adenylate cyclase inhibiting metabotropic glutamate receptor activity [Term] id: GO:0001646 name: cAMP receptor activity namespace: molecular_function alt_id: GO:0001644 def: "Combining with cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) to initiate a change in cell activity." [GOC:pg] synonym: "3',5' cAMP receptor activity" EXACT [] synonym: "3',5'-cAMP receptor activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate receptor activity" EXACT [] synonym: "class E G protein coupled receptor" BROAD [] synonym: "class E G-protein coupled receptor" BROAD [] synonym: "class E GPCR" BROAD [] synonym: "cyclic AMP receptor activity" EXACT [] is_a: GO:0016502 ! nucleotide receptor activity is_a: GO:0030552 ! cAMP binding [Term] id: GO:0001647 name: G-protein coupled cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity. The receptor is G-protein coupled." [GOC:dph] synonym: "G protein coupled cytokinin receptor activity" EXACT [] synonym: "G-protein-coupled cytokinin receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0001648 name: proteinase activated receptor activity namespace: molecular_function is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0001649 name: osteoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, the mesodermal cell that gives rise to bone." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "osteoblast cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001503 ! ossification [Term] id: GO:0001650 name: fibrillar center namespace: cellular_component def: "A structure found most metazoan nucleoli, but not usually found in lower eukaryotes; surrounded by the dense fibrillar component; the zone of transcription from multiple copies of the pre-rRNA genes is in the border region between these two structures." [PMID:10754561] synonym: "fibrillar centre" EXACT [] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001651 name: dense fibrillar component namespace: cellular_component def: "A structure found in the nucleolus, which contains newly synthesized preribosomal RNA (pre-rRNA) and a collection of proteins." [PMID:10754561] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001652 name: granular component namespace: cellular_component def: "A structure found in the nucleolus, which contains nearly completed preribosomal particles destined for the cytoplasm." [PMID:10754561] is_a: GO:0044452 ! nucleolar part [Term] id: GO:0001653 name: peptide receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a change in cell activity." [GOC:jl] synonym: "endogenous peptide receptor activity" NARROW [] synonym: "exogenous peptide receptor activity" NARROW [] is_a: GO:0004872 ! receptor activity is_a: GO:0042277 ! peptide binding [Term] id: GO:0001654 name: eye development namespace: biological_process alt_id: GO:0042460 def: "The process whose specific outcome is the progression of the eye over time, from its formation to the mature structure. The eye is the organ of sight." [GOC:jid, GOC:jl] xref: Wikipedia:Eye_development is_a: GO:0007423 ! sensory organ development [Term] id: GO:0001655 name: urogenital system development namespace: biological_process def: "The process whose specific outcome is the progression of the urogenital system over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048731 ! system development [Term] id: GO:0001656 name: metanephros development namespace: biological_process def: "The process whose specific outcome is the progression of the metanephros over time, from its formation to the mature structure. In mammals, the metanephros is the excretory organ of the fetus, which develops into the mature kidney and is formed from the rear portion of the nephrogenic cord. The metanephros is an endocrine and metabolic organ that filters the blood and excretes the end products of body metabolism in the form of urine." [GOC:bf, ISBN:0192800752] is_a: GO:0001822 ! kidney development [Term] id: GO:0001657 name: ureteric bud development namespace: biological_process def: "The process whose specific outcome is the progression of the ureteric bud over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0035295 ! tube development [Term] id: GO:0001658 name: branching involved in ureteric bud morphogenesis namespace: biological_process def: "The process by which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules." [GOC:dph, PMID:16916378] synonym: "ureteric bud branching" EXACT [GOC:dph] is_a: GO:0048754 ! branching morphogenesis of a tube is_a: GO:0061138 ! morphogenesis of a branching epithelium relationship: part_of GO:0060675 ! ureteric bud morphogenesis [Term] id: GO:0001659 name: temperature homeostasis namespace: biological_process def: "A homeostatic process by which an organism modulates its internal body temperature." [GOC:jl] synonym: "thermoregulation" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Thermoregulation is_a: GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001660 name: fever namespace: biological_process def: "A rise in body temperature above the normal, often as a response to infection." [GOC:jl] synonym: "pyrexia" BROAD [] xref: Wikipedia:Fever is_a: GO:0006953 ! acute-phase response is_a: GO:0031649 ! heat generation [Term] id: GO:0001661 name: conditioned taste aversion namespace: biological_process def: "A conditioned aversion to a specific chemical compound as a result of that compound being coupled with a noxious stimulus." [GOC:dph, PMID:9920659] xref: Wikipedia:Conditioned_taste_aversion xref: Wikipedia:Taste_aversion is_a: GO:0007631 ! feeding behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0001662 name: behavioral fear response namespace: biological_process def: "An acute behavioral change resulting from a perceived external threat." [GOC:dph, PMID:9920659] synonym: "behavioural fear response" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0042596 ! fear response [Term] id: GO:0001664 name: G-protein-coupled receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein-coupled receptor." [GOC:ceb, GOC:dph] synonym: "G protein coupled receptor binding" EXACT [] synonym: "G protein coupled receptor ligand" NARROW [] synonym: "G-protein-coupled receptor ligand" NARROW [] xref: Reactome:260 "G-protein-coupled receptor binding" is_a: GO:0005102 ! receptor binding [Term] id: GO:0001665 name: alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein = CMP + glycano-(2,6-alpha-N-acetylneuraminyl)-(N-acetyl-D-galactosaminyl)-glycoprotein." [EC:2.4.99.3] synonym: "CMP-N-acetylneuraminate:glycano-1,3-(N-acetyl-alpha-D-galactosaminyl)-glycoprotein alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.3] synonym: "GalNAc alpha-2,6-sialyltransferase I activity" EXACT [EC:2.4.99.3] xref: EC:2.4.99.3 xref: MetaCyc:2.4.99.3-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0001666 name: response to hypoxia namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating lowered oxygen tension. Hypoxia, defined as a decline in O2 levels below normoxic levels of 20.8 - 20.95%, results in metabolic adaptation at both the cellular and organismal level." [GOC:hjd] comment: Note that this term should not be confused with 'response to anoxia ; GO:0034059'. Note that in laboratory studies, hypoxia is typically studied at O2 concentrations ranging from 0.1 - 5%. synonym: "response to hypoxic stress" EXACT [] synonym: "response to lowered oxygen tension" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0001667 name: ameboidal cell migration namespace: biological_process def: "Cell migration that is accomplished by extension and retraction of a pseudopodium." [GOC:dph] synonym: "ameboid cell migration" EXACT [] synonym: "amoeboid cell migration" EXACT [] synonym: "amoeboidal cell migration" EXACT [] is_a: GO:0016477 ! cell migration [Term] id: GO:0001669 name: acrosomal vesicle namespace: cellular_component def: "A structure in the head of a spermatozoon that contains acid hydrolases, and is concerned with the breakdown of the outer membrane of the ovum during fertilization. It lies just beneath the plasma membrane and is derived from the lysosome." [ISBN:0124325653, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "acrosome" RELATED [GOC:dph] xref: Wikipedia:Acrosome is_a: GO:0030141 ! stored secretory granule [Term] id: GO:0001670 name: dopamine D2 receptor activity namespace: molecular_function def: "A G-protein coupled receptor that binds dopamine and has the pharmacological characteristics of classic D2 receptors." [IUPHAR_RECEPTOR:2254] is_a: GO:0001591 ! dopamine receptor activity, coupled via Gi/Go [Term] id: GO:0001671 name: ATPase activator activity namespace: molecular_function def: "Functions to increase the rate of ATP hydrolysis." [GOC:ajp] synonym: "ATPase stimulator activity" EXACT [] is_a: GO:0008047 ! enzyme activator activity is_a: GO:0060590 ! ATPase regulator activity relationship: positively_regulates GO:0016887 ! ATPase activity [Term] id: GO:0001672 name: regulation of chromatin assembly or disassembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chromatin assembly or disassembly." [GOC:go_curators] synonym: "regulation of chromatin assembly/disassembly" EXACT [] is_a: GO:0033044 ! regulation of chromosome organization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006333 ! chromatin assembly or disassembly relationship: regulates GO:0006333 ! chromatin assembly or disassembly [Term] id: GO:0001673 name: male germ cell nucleus namespace: cellular_component alt_id: GO:0043081 def: "The nucleus of a male germ cell, a reproductive cell in males." [GOC:hjd, GOC:mtg_sensu, http://cancerweb.ncl.ac.uk] synonym: "male germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001674 name: female germ cell nucleus namespace: cellular_component alt_id: GO:0043080 def: "The nucleus of the female germ cell, a reproductive cell in females." [GOC:hjd, http://cancerweb.ncl.ac.uk] synonym: "female germ-cell nucleus" EXACT [] is_a: GO:0043073 ! germ cell nucleus [Term] id: GO:0001675 name: acrosome assembly namespace: biological_process def: "The formation of the acrosome from the spermatid Golgi." [GOC:dph, GOC:hjd, GOC:tb] synonym: "acrosome formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0001676 name: long-chain fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving long-chain fatty acids, aliphatic compounds having a terminal carboxyl group and with a chain length of C12-18." [GOC:ajp] subset: gosubset_prok synonym: "long-chain fatty acid metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0001677 name: formation of translation initiation ternary complex namespace: biological_process def: "Formation of a complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2 (either eIF2 in eukaryotes, or IF2 in prokaryotes). In prokaryotes, fMet-tRNA (initiator) is used rather than Met-tRNA (initiator)." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation ternary complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001678 name: cellular glucose homeostasis namespace: biological_process def: "A cellular homeostatic process involved in the maintenance of an internal steady-state of glucose within a cell or between a cell and its external environment." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "cell glucose homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0042593 ! glucose homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0001680 name: tRNA 3'-terminal CCA addition namespace: biological_process def: "Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript." [GOC:go_curators] subset: gosubset_prok is_a: GO:0042780 ! tRNA 3'-end processing [Term] id: GO:0001681 name: sialate O-acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-O-acetylneuraminate (free or glycosidically bound) + H2O = N-acetylneuraminate + acetate." [EC:3.1.1.53, PMID:1991039] subset: gosubset_prok synonym: "N-acetylneuraminate acetyltransferase activity" EXACT [EC:3.1.1.53] synonym: "N-acyl-O-acetylneuraminate O-acetylhydrolase activity" EXACT [EC:3.1.1.53] synonym: "sialate 9(4)-O-acetylesterase activity" EXACT [] xref: EC:3.1.1.53 xref: MetaCyc:SIALATE-O-ACETYLESTERASE-RXN is_a: GO:0008126 ! acetylesterase activity [Term] id: GO:0001682 name: tRNA 5'-leader removal namespace: biological_process def: "Generation of the mature 5'-end of the tRNA, usually via an endonucleolytic cleavage by RNase P." [PMID:11592395] subset: gosubset_prok synonym: "tRNA 5' leader removal" EXACT [] is_a: GO:0008033 ! tRNA processing [Term] id: GO:0001683 name: axonemal dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001684 name: axonemal dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001685 name: axonemal dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001686 name: axonemal dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005858 [Term] id: GO:0001687 name: cytoplasmic dynein heavy chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001688 name: cytoplasmic dynein intermediate chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001689 name: cytoplasmic dynein intermediate light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001690 name: cytoplasmic dynein light chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005868 [Term] id: GO:0001691 name: pseudophosphatase activity namespace: molecular_function def: "Maintains the phosphorylation state of certain molecules by associating with them and preventing them from associating with active phosphatases, and thus inhibiting the enzyme activity without interacting with the enzyme. Often pertains to proteins belonging to dual-specificity phosphatase family but lacking critical active site residues." [GOC:ajp] is_a: GO:0019212 ! phosphatase inhibitor activity [Term] id: GO:0001692 name: histamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0001694 name: histamine biosynthetic process namespace: biological_process alt_id: GO:0001693 def: "The chemical reactions and pathways resulting in the formation of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine anabolism" EXACT [] synonym: "histamine biosynthesis" EXACT [] synonym: "histamine formation" EXACT [] synonym: "histamine synthesis" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0001695 name: histamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histamine, a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:jl, ISBN:0395825172] synonym: "histamine breakdown" EXACT [] synonym: "histamine catabolism" EXACT [] synonym: "histamine degradation" EXACT [] is_a: GO:0001692 ! histamine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0001696 name: gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid (hydrochloric acid) by parietal or oxyntic cells during digestion." [GOC:hjd] synonym: "hydrochloric acid secretion" NARROW [] is_a: GO:0022600 ! digestive system process is_a: GO:0046717 ! acid secretion [Term] id: GO:0001697 name: histamine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of histamine with H2 type receptor receptors with subsequent activation of adenylate cyclase and elevation of intracellular cyclic AMP." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001698 name: gastrin-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid induced by the interaction of gastrin with its receptor." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001699 name: acetylcholine-induced gastric acid secretion namespace: biological_process def: "The regulated release of gastric acid by parietal cells in response to acetylcholine." [GOC:hjd] is_a: GO:0001696 ! gastric acid secretion [Term] id: GO:0001700 name: embryonic development via the syncytial blastoderm namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation through syncytial blastoderm to the hatching of the first instar larva. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0009792 ! embryo development ending in birth or egg hatching [Term] id: GO:0001701 name: in utero embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the embryo in the uterus over time, from formation of the zygote in the oviduct, to birth. An example of this process is found in Mus musculus." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0043009 ! chordate embryonic development [Term] id: GO:0001702 name: gastrulation with mouth forming second namespace: biological_process alt_id: GO:0010003 alt_id: GO:0048276 def: "A gastrulation process in which the initial invagination becomes the anus and the mouth forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "deuterostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001703 name: gastrulation with mouth forming first namespace: biological_process def: "A gastrulation process in which the initial invagination becomes the mouth and the anus forms second." [GOC:go_curators, GOC:mtg_sensu] synonym: "protostomic gastrulation" EXACT [GOC:dph] is_a: GO:0007369 ! gastrulation [Term] id: GO:0001704 name: formation of primary germ layer namespace: biological_process def: "The formation of the ectoderm, mesoderm and endoderm during gastrulation." [GOC:go_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007369 ! gastrulation [Term] id: GO:0001705 name: ectoderm formation namespace: biological_process def: "The formation of ectoderm during gastrulation." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0001706 name: endoderm formation namespace: biological_process def: "The formation of the endoderm during gastrulation." [GOC:go_curators] synonym: "endoblast formation" NARROW [GOC:dph, GOC:sdb_2009, GOC:tb] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0007492 ! endoderm development [Term] id: GO:0001707 name: mesoderm formation namespace: biological_process def: "The process that gives rise to the mesoderm. This process pertains to the initial formation of the structure from unspecified parts." [GOC:go_curators] is_a: GO:0001704 ! formation of primary germ layer relationship: part_of GO:0048332 ! mesoderm morphogenesis [Term] id: GO:0001708 name: cell fate specification namespace: biological_process def: "The process involved in the specification of cell identity. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment." [GOC:go_curators] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001709 name: cell fate determination namespace: biological_process def: "Process involved in cell fate commitment. Once determination has taken place, a cell becomes committed to differentiate down a particular pathway regardless of its environment." [ISBN:0878932437] xref: Wikipedia:Cell_fate_determination is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0045165 ! cell fate commitment [Term] id: GO:0001710 name: mesodermal cell fate commitment namespace: biological_process def: "The process by which a cell becomes committed to become part of the mesoderm." [GOC:go_curators, ISBN:0878932437] synonym: "mesoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers relationship: part_of GO:0048333 ! mesodermal cell differentiation [Term] id: GO:0001711 name: endodermal cell fate commitment namespace: biological_process def: "The process by which a cell becomes committed to become part of the endoderm." [GOC:go_curators, ISBN:0878932437] synonym: "endoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers relationship: part_of GO:0001706 ! endoderm formation [Term] id: GO:0001712 name: ectodermal cell fate commitment namespace: biological_process def: "The process by which a cell becomes committed to become part of the ectoderm." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate commitment" EXACT [] is_a: GO:0060795 ! cell fate commitment involved in the formation of primary germ layers relationship: part_of GO:0001705 ! ectoderm formation relationship: part_of GO:0010668 ! ectodermal cell differentiation [Term] id: GO:0001713 name: ectodermal cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] synonym: "ectoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001714 name: endodermal cell fate specification namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "endoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0001715 name: ectodermal cell fate specification namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into an ectoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] synonym: "ectoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001712 ! ectodermal cell fate commitment [Term] id: GO:0001716 name: L-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a L-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.2] subset: gosubset_prok synonym: "L-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.2] synonym: "ophio-amino-acid oxidase activity" EXACT [EC:1.4.3.2] xref: EC:1.4.3.2 xref: MetaCyc:L-AMINO-ACID-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0001717 name: conversion of seryl-tRNAsec to selenocys-tRNAsec namespace: biological_process def: "Process whereby serine carried by a specialized tRNA(ser) (which can read a UGA anticodon) is converted to selenocysteine." [ISBN:155581073X] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001720 name: conversion of lysyl-tRNA to pyrrolysyl-tRNA namespace: biological_process def: "Process whereby lysine carried by a specialized lysine-accepting tRNA (possessing a CUA anticodon) is converted to pyrrolysine (a lysine with an amide linkage to a (4R,5R)-4-substituted pyrroline-5-carboxylate)." [PMID:12029131, PMID:12029132, PMID:12121639] subset: gosubset_prok is_a: GO:0019988 ! charged-tRNA amino acid modification [Term] id: GO:0001721 name: intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with intermediate filaments and function in the supramolecular organization of cellular intermediate filament networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "IFAP" EXACT [] is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001722 name: type I intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Low molecular weight (10-45 kDa) proteins that associate with intermediate filaments by lateral binding of the filaments and have the effect of creating tight macrofilament aggregates." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001723 name: type II intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. High molecular weight (100-300 kDa) proteins that associate with intermediate filaments to cross-link them into loose networks." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005882 [Term] id: GO:0001724 name: type III intermediate filament associated protein namespace: cellular_component def: "OBSOLETE. Proteins that associate with the ends of intermediate filaments and couple the intermediate filaments to the plasma membrane." [GOC:ajp, PMID:9484600] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0045098 [Term] id: GO:0001725 name: stress fiber namespace: cellular_component def: "A contractile actin filament bundle that consists of short actin filaments with alternating polarity, cross-linked by alpha-actinin and possibly other actin bundling proteins, and with myosin present in a periodic distribution along the fiber." [PMID:16651381] synonym: "actin cable" RELATED [GOC:mah] synonym: "stress fibre" EXACT [] is_a: GO:0032432 ! actin filament bundle is_a: GO:0042641 ! actomyosin [Term] id: GO:0001726 name: ruffle namespace: cellular_component def: "Projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork." [ISBN:0124325653] synonym: "membrane ruffle" RELATED [] is_a: GO:0042995 ! cell projection relationship: part_of GO:0031252 ! cell leading edge [Term] id: GO:0001727 name: lipid kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of a simple or complex lipid." [GOC:hjd] subset: gosubset_prok is_a: GO:0016301 ! kinase activity relationship: part_of GO:0046834 ! lipid phosphorylation [Term] id: GO:0001729 name: ceramide kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ceramide = ADP + ceramide 1-phosphate." [EC:2.7.1.138] synonym: "acylsphingosine kinase activity" EXACT [EC:2.7.1.138] synonym: "ATP:ceramide 1-phosphotransferase activity" EXACT [EC:2.7.1.138] xref: EC:2.7.1.138 xref: MetaCyc:CERAMIDE-KINASE-RXN is_a: GO:0001727 ! lipid kinase activity [Term] id: GO:0001730 name: 2'-5'-oligoadenylate synthetase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = pppA(2'p5'A)n oligomers. Requires binding of double-stranded RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "(2-5')oligo(A) synthetase activity" EXACT [] synonym: "2'-5' oligoadenylate synthetase activity" EXACT [] synonym: "2-5A synthetase activity" EXACT [] synonym: "oligo-2',5'-adenylate synthetase activity" EXACT [] is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0001731 name: formation of translation preinitiation complex namespace: biological_process def: "The joining of the small ribosomal subunit, ternary complex, and mRNA." [GOC:hjd] comment: See also the cellular component terms 'eukaryotic 43S preinitiation complex ; GO:0016282', 'eukaryotic 48S initiation complex ; GO:0033290', and their children. subset: gosubset_prok synonym: "formation of translation pre-initiation complex" EXACT [] synonym: "translation preinitiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001732 name: formation of translation initiation complex namespace: biological_process def: "Joining of the large subunit, with release of IF2/eIF2 and IF3/eIF3. This leaves the functional ribosome at the AUG, with the methionyl/formyl-methionyl-tRNA positioned at the P site." [GOC:hjd] subset: gosubset_prok synonym: "translation initiation complex assembly" EXACT [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0001733 name: galactosylceramide sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate." [EC:2.8.2.11, PMID:10727929] synonym: "3'-phosphoadenosine-5'-phosphosulfate-cerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "3'-phosphoadenylyl-sulfate:galactosylceramide 3'-sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "cerebroside sulfotransferase activity" EXACT [] synonym: "galactocerebroside sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "galactosylceramide sulphotransferase activity" EXACT [] synonym: "glycolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "glycosphingolipid sulfotransferase activity" EXACT [EC:2.8.2.11] synonym: "GSase" EXACT [EC:2.8.2.11] xref: EC:2.8.2.11 xref: MetaCyc:GALACTOSYLCERAMIDE-SULFOTRANSFERASE-RXN is_a: GO:0050694 ! galactose 3-O-sulfotransferase activity [Term] id: GO:0001734 name: mRNA (N6-adenosine)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + RRACH = S-adenosyl-L-homocysteine + RRm6ACH; R = purine, and H = C, A, or U." [GOC:hjd] xref: Reactome:2399 "mRNA (N6-adenosine)-methyltransferase activity" is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0001735 name: prenylcysteine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: S-prenyl-L-cysteine + O2 + H20 = a prenal + L-cysteine + H202." [GOC:hjd] synonym: "prenylcysteine lyase activity" EXACT [EC:1.8.3.5] synonym: "S-prenyl-L-cysteine:oxygen oxidoreductase activity" EXACT [EC:1.8.3.5] xref: EC:1.8.3.5 xref: MetaCyc:1.8.3.5-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: GO:0001736 name: establishment of planar polarity namespace: biological_process def: "Coordinated organization of groups of cells in the plane of an epithelium, such that they all orient to similar coordinates." [GOC:dph] synonym: "establishment of planar cell polarity" NARROW [] is_a: GO:0007164 ! establishment of tissue polarity relationship: part_of GO:0001738 ! morphogenesis of a polarized epithelium [Term] id: GO:0001737 name: establishment of imaginal disc-derived wing hair orientation namespace: biological_process def: "Orientation of hairs in the imaginal disc-derived wing along a proximal-distal axis, such that each cell of the wing produces one wing hair which points in a distal direction." [GOC:ascb_2009, GOC:dph, GOC:mtg_sensu, GOC:tb, PMID:11239465] synonym: "establishment of wing hair orientation" EXACT [] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0035317 ! imaginal disc-derived wing hair organization [Term] id: GO:0001738 name: morphogenesis of a polarized epithelium namespace: biological_process def: "The process by which the anatomical structures of a polarized epithelium are generated and organized. Morphogenesis pertains to the creation of form. A polarized epithelium is an epithelium where the epithelial sheet is oriented with respect to the planar axis." [GOC:dph] synonym: "epithelial polarization" EXACT [GOC:dph] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0001739 name: sex chromatin namespace: cellular_component def: "A condensed mass of compacted chromatin that represents an inactivated X chromosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005720 ! nuclear heterochromatin intersection_of: GO:0005720 ! nuclear heterochromatin intersection_of: part_of GO:0000803 ! sex chromosome relationship: part_of GO:0000803 ! sex chromosome [Term] id: GO:0001740 name: Barr body namespace: cellular_component def: "A structure found in a female mammalian cell containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] xref: Wikipedia:Barr_body is_a: GO:0000228 ! nuclear chromosome is_a: GO:0000805 ! X chromosome is_a: GO:0001739 ! sex chromatin [Term] id: GO:0001741 name: XY body namespace: cellular_component def: "A structure found in a male mammalian spermatocyte containing an unpaired X chromosome that has become densely heterochromatic, silenced and localized at the nuclear periphery." [GOC:hjd] is_a: GO:0001739 ! sex chromatin [Term] id: GO:0001742 name: oenocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an oenocyte. Oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:go_curators] synonym: "oenocyte cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation [Term] id: GO:0001743 name: optic placode formation namespace: biological_process def: "The initial developmental process that will lead to the formation of an eye." [GOC:dph] is_a: GO:0060788 ! ectodermal placode formation relationship: part_of GO:0048598 ! embryonic morphogenesis [Term] id: GO:0001744 name: optic lobe placode formation namespace: biological_process alt_id: GO:0007457 def: "Establishment of the optic placode, a thickened area of densely packed ectoderm cells directly overlying the optic vesicle in the early embryo. In Drosophila, for example, the placode appears in the dorsolateral region of the head in late stage 11 embryos and is the precursor to the larval visual system." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor formation" EXACT [] is_a: GO:0001743 ! optic placode formation relationship: part_of GO:0001748 ! optic lobe placode development [Term] id: GO:0001745 name: compound eye morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the compound eye are generated and organized. Morphogenesis pertains to the creation of form. The adult compound eye is a precise assembly of 700-800 ommatidia. Each ommatidium is composed of 20 cells, identified by cell type and position. An example of compound eye morphogenesis is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu] synonym: "insect-type retina morphogenesis" EXACT [PMID:11735386] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0048749 ! compound eye development [Term] id: GO:0001746 name: Bolwig's organ morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the larval eye in Drosophila are generated and organized. Morphogenesis pertains to the creation of form. The larval eye in Drosophila is a relatively simple sensory system composed of Bolwig's organs: two clusters, each composed of 12 photoreceptor cells from which axons extend in a single fascicle to the brain." [http://sdb.bio.purdue.edu/fly/torstoll/tailess.htm#bolwigs, PMID:6185380] is_a: GO:0048592 ! eye morphogenesis relationship: part_of GO:0055034 ! Bolwig's organ development [Term] id: GO:0001748 name: optic lobe placode development namespace: biological_process alt_id: GO:0048049 def: "The process whose specific outcome is the progression of the optic placode over time, from its formation to the mature structure. During embryonic stage 12 the placode starts to invaginate, forming a pouch. Cells that will form Bolwig's organ segregate from the ventral lip of this pouch, remaining in the head epidermis. The remainder of the invagination loses contact with the outer surface and becomes the optic lobe. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8402833] synonym: "optic lobe and Bolwig's organ precursor development" EXACT [] synonym: "optic placode development" BROAD [] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0001750 name: photoreceptor outer segment namespace: cellular_component def: "The outer segment of a vertebrate photoreceptor that contains discs of photoreceptive membranes." [ISBN:0824072820] is_a: GO:0031513 ! nonmotile primary cilium [Term] id: GO:0001751 name: compound eye photoreceptor cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an eye photoreceptor cell." [GOC:go_curators] is_a: GO:0001754 ! eye photoreceptor cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0001752 name: compound eye photoreceptor fate commitment namespace: biological_process alt_id: GO:0007459 def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a compound eye photoreceptor cell. A photoreceptor cell is a cell that responds to incident electromagnetic radiation. Different classes of photoreceptor have different spectral sensitivities and express different photosensitive pigments." [GOC:mtg_sensu] is_a: GO:0042706 ! eye photoreceptor cell fate commitment relationship: part_of GO:0001751 ! compound eye photoreceptor cell differentiation [Term] id: GO:0001753 name: adult eye photoreceptor development (sensu Drosophila) namespace: biological_process def: "OBSOLETE. Development of a photoreceptor, a receptor that responds to light, in the adult Drosophila eye." [GOC:go_curators] comment: This term was made obsolete because eye photoreceptors have completed their development by the time the adult phase begins. is_obsolete: true consider: GO:0042051 [Term] id: GO:0001754 name: eye photoreceptor cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a photoreceptor cell, as found in the eye, the primary visual organ of most organisms." [GOC:go_curators] is_a: GO:0046530 ! photoreceptor cell differentiation relationship: part_of GO:0048592 ! eye morphogenesis [Term] id: GO:0001755 name: neural crest cell migration namespace: biological_process def: "The characteristic movement of cells from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo." [GOC:ascb_2009, GOC:dph, GOC:tb, ISBN:0878932437] is_a: GO:0001667 ! ameboidal cell migration relationship: part_of GO:0014032 ! neural crest cell development [Term] id: GO:0001756 name: somitogenesis namespace: biological_process def: "The formation of mesodermal clusters that are arranged segmentally along the anterior posterior axis of an embryo." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "formation of mesodermal clusters" EXACT systematic_synonym [] xref: Wikipedia:Somitogenesis is_a: GO:0009952 ! anterior/posterior pattern formation is_a: GO:0035282 ! segmentation is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0043009 ! chordate embryonic development relationship: part_of GO:0061053 ! somite development [Term] id: GO:0001757 name: somite specification namespace: biological_process def: "The process by which individual somites establish identity during embryogenesis." [GOC:dph] is_a: GO:0007379 ! segment specification is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0001756 ! somitogenesis [Term] id: GO:0001758 name: retinal dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinal + NAD+ + H2O = retinoate + NADH. Acts on both 11-trans and 13-cis forms of retinal." [EC:1.2.1.36] synonym: "cytosolic retinal dehydrogenase activity" EXACT [EC:1.2.1.36] synonym: "retinal:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.36] xref: EC:1.2.1.36 xref: MetaCyc:RETINAL-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0001759 name: induction of an organ namespace: biological_process def: "The interaction of two or more cells or tissues that causes them to change their fates and specify the development of an organ." [ISBN:0878932437] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0031128 ! developmental induction is_a: GO:0051094 ! positive regulation of developmental process relationship: positively_regulates GO:0010092 ! specification of organ identity [Term] id: GO:0001760 name: aminocarboxymuconate-semialdehyde decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-3-(3-oxoprop-2-enyl)-but-2-enedioate = 2-aminomuconate semialdehyde + CO2." [EC:4.1.1.45] subset: gosubset_prok synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase (2-aminomuconate-semialdehyde-forming)" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-1-en-1-yl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "2-amino-3-(3-oxoprop-2-enyl)but-2-enedioate carboxy-lyase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehade decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "alpha-amino-beta-carboxymuconate-epsilon-semialdehyde beta-decarboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid carboxylase activity" EXACT [EC:4.1.1.45] synonym: "picolinic acid decarboxylase activity" EXACT [EC:4.1.1.45] xref: EC:4.1.1.45 xref: MetaCyc:AMINO-CARBOXYMUCONATE-SEMIALDEHYDE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0001761 name: beta-alanine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of beta-alanine from one side of a membrane to the other. Beta-alanine is 3-aminopropanoic acid." [GOC:hjd] synonym: "beta-alanine transporter activity" BROAD [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity relationship: part_of GO:0001762 ! beta-alanine transport [Term] id: GO:0001762 name: beta-alanine transport namespace: biological_process def: "The directed movement of beta-alanine, 3-aminopropanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:hjd] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0001763 name: morphogenesis of a branching structure namespace: biological_process def: "The process by which the anatomical structures of branches are generated and organized. Morphogenesis pertains to the creation of form. A branch is a division or offshoot from a main stem. Examples in animals would include blood vessels, nerves, lymphatics and other endothelial or epithelial tubes." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "branching morphogenesis" EXACT [GOC:dph] is_a: GO:0009653 ! anatomical structure morphogenesis is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001764 name: neuron migration namespace: biological_process def: "The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature." [GOC:go_curators] synonym: "neuron chemotaxis" EXACT [GOC:curators] synonym: "neuron guidance" RELATED [GOC:curators] synonym: "neuronal migration" EXACT [] xref: Wikipedia:Neural_development#Neuron_migration xref: Wikipedia:Neuron_migration is_a: GO:0016477 ! cell migration relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0001765 name: membrane raft assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a membrane raft, a small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalizes cellular processes." [PMID:12648772, PMID:12803918, PMID:16645198] synonym: "lipid raft assembly" EXACT [GOC:mah] synonym: "lipid raft formation" RELATED [] synonym: "membrane raft formation" RELATED [GOC:mah] is_a: GO:0022607 ! cellular component assembly is_a: GO:0031579 ! membrane raft organization [Term] id: GO:0001766 name: membrane raft polarization namespace: biological_process def: "The clustering and aggregation of membrane rafts at a single cellular pole during activation of particular cell types, such as lymphocytes." [PMID:12615889] synonym: "lipid raft polarization" EXACT [] is_a: GO:0031580 ! membrane raft distribution [Term] id: GO:0001767 name: establishment of lymphocyte polarity namespace: biological_process def: "The directed orientation of lymphocyte signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with an appropriate activating cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "lymphocyte polarization" EXACT [] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001768 name: establishment of T cell polarity namespace: biological_process def: "The directed orientation of T cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with antigen presenting cell." [GOC:mgi_curators, PMID:11244041, PMID:12615889] synonym: "establishment of T lymphocyte polarity" EXACT [] synonym: "establishment of T-cell polarity" EXACT [] synonym: "establishment of T-lymphocyte polarity" EXACT [] synonym: "T cell polarization" EXACT [] synonym: "T lymphocyte polarization" EXACT [] synonym: "T-cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042110 ! T cell activation [Term] id: GO:0001769 name: establishment of B cell polarity namespace: biological_process def: "The directed orientation of B cell signaling molecules and associated membrane rafts towards a chemokine gradient of a contact point with an antigen displaying cell." [GOC:mgi_curators, PMID:12615889, PMID:9692889] comment: Note that 'antigen displaying cell' in this term encompasses cell types such as follicular dendritic cells which display the unprocessed antigens of a B cell, leading to activation of the B cells and antigen uptake and processing by the B cells. synonym: "B cell polarization" EXACT [] synonym: "B lymphocyte polarization" EXACT [] synonym: "B-cell polarization" EXACT [] synonym: "establishment of B lymphocyte polarity" EXACT [] synonym: "establishment of B-cell polarity" EXACT [] synonym: "establishment of B-lymphocyte polarity" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0042113 ! B cell activation [Term] id: GO:0001770 name: establishment of natural killer cell polarity namespace: biological_process def: "The directed orientation of natural killer cell signaling molecules and associated membrane rafts towards a chemokine gradient or a contact point with a cell displaying natural killer cell activating ligands." [GOC:mgi_curators, PMID:12615886, PMID:9759849] synonym: "establishment of NK cell polarity" EXACT [] synonym: "natural killer cell polarization" EXACT [] synonym: "NK cell polarization" EXACT [] is_a: GO:0001767 ! establishment of lymphocyte polarity relationship: part_of GO:0030101 ! natural killer cell activation [Term] id: GO:0001771 name: formation of immunological synapse namespace: biological_process def: "The formation of an area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and target cell, which facilitates activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376330] is_a: GO:0009988 ! cell-cell recognition relationship: part_of GO:0046649 ! lymphocyte activation [Term] id: GO:0001772 name: immunological synapse namespace: cellular_component def: "An area of close contact between a lymphocyte (T-, B-, or natural killer cell) and a target cell formed through the clustering of particular signaling and adhesion molecules and their associated membrane rafts on both the lymphocyte and the target cell and facilitating activation of the lymphocyte, transfer of membrane from the target cell to the lymphocyte, and in some situations killing of the target cell through release of secretory granules and/or death-pathway ligand-receptor interaction." [GOC:mgi_curators, PMID:11244041, PMID:11376300] synonym: "c-SMAC" NARROW [PMID:14724296] synonym: "supramolecular activation cluster" EXACT [PMID:14724296] xref: Wikipedia:Immunological_synapse is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001773 name: myeloid dendritic cell activation namespace: biological_process def: "The change in morphology and behavior of a dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002274 ! myeloid leukocyte activation [Term] id: GO:0001774 name: microglial cell activation namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor." [GOC:mgi_curators, PMID:10626665, PMID:10695728, PMID:12580336, PMID:9893949] is_a: GO:0042116 ! macrophage activation [Term] id: GO:0001775 name: cell activation namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:mgi_curators] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0001776 name: leukocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of cells of the immune system such that the total number of cells of a particular cell type within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term represents the return of immune system cell levels to stable numbers following an immune response as well as the proliferation and elimination of cells of the immune system required to maintain stable numbers in the absence of an outside stimulus. synonym: "immune cell homeostasis" EXACT [] synonym: "leucocyte homeostasis" EXACT [] is_a: GO:0002376 ! immune system process is_a: GO:0048872 ! homeostasis of number of cells [Term] id: GO:0001777 name: T cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of T cell populations within a whole or part of an organism to reach to a total number of T cells which will then remain stable over time in the absence of an external stimulus." [GOC:mgi_curators, ISBN:0781735149 "Fundamental Immunology"] synonym: "resting T cell proliferation" EXACT [] synonym: "resting T-cell proliferation" EXACT [] synonym: "T lymphocyte homeostatic proliferation" EXACT [] synonym: "T-cell homeostatic proliferation" EXACT [] synonym: "T-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042098 ! T cell proliferation relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0001778 name: plasma membrane repair namespace: biological_process def: "The resealing of a cell plasma membrane after cellular wounding due to, for instance, mechanical stress." [GOC:add, PMID:12925704] is_a: GO:0007009 ! plasma membrane organization relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0001779 name: natural killer cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "NK cell differentiation" EXACT [] is_a: GO:0030098 ! lymphocyte differentiation is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0001780 name: neutrophil homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of neutrophils such that the total number of neutrophils within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:12752675, PMID:12960266] comment: Note that this term represents the return of neutrophil levels to stable numbers following an immune response as well as the proliferation and elimination of neutrophils required to maintain stable numbers in the absence of an outside stimulus. is_a: GO:0002262 ! myeloid cell homeostasis [Term] id: GO:0001781 name: neutrophil apoptosis namespace: biological_process def: "The process of apoptosis in neutrophils." [GOC:add, PMID:12752675, PMID:12960266] synonym: "apoptosis of neutrophils" EXACT [] synonym: "neutrophil programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of neutrophils by apoptosis" EXACT [] synonym: "programmed cell death, neutrophils" EXACT [] is_a: GO:0033028 ! myeloid cell apoptosis relationship: part_of GO:0001780 ! neutrophil homeostasis [Term] id: GO:0001782 name: B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells such that the total number of B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12956429] comment: Note that this term represents the return of B cell levels to stable numbers following an immune response as well as the proliferation and elimination of B cells required to maintain stable numbers in the absence of an outside stimulus. synonym: "B lymphocyte homeostasis" EXACT [] synonym: "B-cell homeostasis" EXACT [] synonym: "B-lymphocyte homeostasis" EXACT [] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0001783 name: B cell apoptosis namespace: biological_process def: "The process of apoptosis in B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "apoptosis of B cells" EXACT [] synonym: "apoptosis of B lymphocytes" EXACT [] synonym: "apoptosis of B-cells" EXACT [] synonym: "apoptosis of B-lymphocytes" EXACT [] synonym: "B cell programmed cell death by apoptosis" EXACT [] synonym: "B lymphocyte apoptosis" EXACT [] synonym: "B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "B-cell apoptosis" EXACT [] synonym: "B-cell programmed cell death by apoptosis" EXACT [] synonym: "B-lymphocyte apoptosis" EXACT [] synonym: "B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of B cells by apoptosis" EXACT [] synonym: "programmed cell death of B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of B-cells by apoptosis" EXACT [] synonym: "programmed cell death of B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, B cells" EXACT [] synonym: "programmed cell death, B lymphocytes" EXACT [] synonym: "programmed cell death, B-cells" EXACT [] synonym: "programmed cell death, B-lymphocytes" EXACT [] is_a: GO:0070227 ! lymphocyte apoptosis [Term] id: GO:0001784 name: phosphotyrosine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a phosphorylated tyrosine residue within a protein." [PMID:14636584] is_a: GO:0045309 ! protein phosphorylated amino acid binding [Term] id: GO:0001785 name: prostaglandin J receptor activity namespace: molecular_function def: "Combining with prostaglandin J (PGJ(2)), a metabolite of prostaglandin D (PGD(2)) to initiate a change in cell activity." [PMID:12878180] synonym: "PGJ receptor activity" RELATED [] synonym: "PGJ(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0001786 name: phosphatidylserine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylserine, a class of glycophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12000961] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0001787 name: natural killer cell proliferation namespace: biological_process def: "The expansion of a natural killer cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "NK cell proliferation" EXACT [] is_a: GO:0030101 ! natural killer cell activation is_a: GO:0046651 ! lymphocyte proliferation [Term] id: GO:0001788 name: antibody-dependent cellular cytotoxicity namespace: biological_process def: "Cytolysis of target cells by natural killer cells, eosinophils, neutrophils, monocytes, or macrophages following engagement of antibodies bound to the target cells by Fc receptors on the effector cells." [ISBN:0781735149 "Fundamental Immunology", PMID:11677095, PMID:9581795] synonym: "ADCC" EXACT [] synonym: "antibody dependent cell death" EXACT [] synonym: "antibody dependent cell killing" EXACT [] synonym: "antibody-dependent cell death" EXACT [] synonym: "antibody-dependent cell killing" EXACT [] synonym: "type VI hypersensitivity" EXACT [] xref: Wikipedia:Antibody-dependent_cell-mediated_cytotoxicity xref: Wikipedia:Antibody-dependent_cellular_cytotoxicity is_a: GO:0001794 ! type IIa hypersensitivity is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0001789 name: G-protein signaling, coupled to S1P second messenger (sphingosine kinase activating) namespace: biological_process def: "A G-protein coupled signaling pathway that results in the activation of sphingosine kinase, causing an increase in cellular levels of sphingosine-1-phosphate." [GOC:dph, PMID:14592418] synonym: "G protein signaling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] synonym: "G-protein signalling, coupled to S1P second messenger (sphingosine kinase activating)" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0001790 name: polymeric immunoglobulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001791 name: IgM binding namespace: molecular_function def: "Interacting selectively and non-covalently with an immunoglobulin of the IgM isotype." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019865 ! immunoglobulin binding [Term] id: GO:0001792 name: polymeric immunoglobulin receptor activity namespace: molecular_function def: "Combining with a J-chain-containing polymeric immunoglobulin of the IgA or IgM isotypes via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001790 ! polymeric immunoglobulin binding is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001793 name: IgM receptor activity namespace: molecular_function def: "Combining with an immunoglobulin of the IgM isotype via the Fc region to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001791 ! IgM binding is_a: GO:0019763 ! immunoglobulin receptor activity [Term] id: GO:0001794 name: type IIa hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death mediated by activation of the classical complement pathway or induction of effector cell phagocytosis or cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that some type IIb hypersensitivity responses (GO:0001795) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIa hypersensitivity. is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001795 name: type IIb hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that some type IIa hypersensitivity response (GO:0001794) are referred to simply as type II hypersensitivity in the earlier literature, but are mechanistically distinct from type IIb hypersensitivity. synonym: "type V hypersensitivity" EXACT [] is_a: GO:0002445 ! type II hypersensitivity [Term] id: GO:0001796 name: regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001794 ! type IIa hypersensitivity relationship: regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001797 name: negative regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IIa hypersensitivity" EXACT [] synonym: "down-regulation of type IIa hypersensitivity" EXACT [] synonym: "downregulation of type IIa hypersensitivity" EXACT [] synonym: "inhibition of type IIa hypersensitivity" NARROW [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001794 ! type IIa hypersensitivity relationship: negatively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001798 name: positive regulation of type IIa hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIa hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IIa hypersensitivity" NARROW [] synonym: "stimulation of type IIa hypersensitivity" NARROW [] synonym: "up regulation of type IIa hypersensitivity" EXACT [] synonym: "up-regulation of type IIa hypersensitivity" EXACT [] synonym: "upregulation of type IIa hypersensitivity" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001794 ! type IIa hypersensitivity relationship: positively_regulates GO:0001794 ! type IIa hypersensitivity [Term] id: GO:0001799 name: regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001795 ! type IIb hypersensitivity relationship: regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001800 name: negative regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IIb hypersensitivity" EXACT [] synonym: "down-regulation of type IIb hypersensitivity" EXACT [] synonym: "downregulation of type IIb hypersensitivity" EXACT [] synonym: "inhibition of type IIb hypersensitivity" NARROW [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002893 ! negative regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001795 ! type IIb hypersensitivity relationship: negatively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001801 name: positive regulation of type IIb hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IIb hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IIb hypersensitivity" NARROW [] synonym: "stimulation of type IIb hypersensitivity" NARROW [] synonym: "up regulation of type IIb hypersensitivity" EXACT [] synonym: "up-regulation of type IIb hypersensitivity" EXACT [] synonym: "upregulation of type IIb hypersensitivity" EXACT [] is_a: GO:0001799 ! regulation of type IIb hypersensitivity is_a: GO:0002894 ! positive regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001795 ! type IIb hypersensitivity relationship: positively_regulates GO:0001795 ! type IIb hypersensitivity [Term] id: GO:0001802 name: type III hypersensitivity namespace: biological_process def: "An inflammatory response resulting from recognition of immune complexes via complement or Fc receptors on effector cells leading to activation of neutrophils and other leukocytes and damage to bystander tissue." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the Arthus reaction is an example of type III hypersensitivity. xref: Wikipedia:Type_III_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0001803 name: regulation of type III hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001802 ! type III hypersensitivity relationship: regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001804 name: negative regulation of type III hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type III hypersensitivity" EXACT [] synonym: "down-regulation of type III hypersensitivity" EXACT [] synonym: "downregulation of type III hypersensitivity" EXACT [] synonym: "inhibition of type III hypersensitivity" NARROW [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001802 ! type III hypersensitivity relationship: negatively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001805 name: positive regulation of type III hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type III hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type III hypersensitivity" NARROW [] synonym: "stimulation of type III hypersensitivity" NARROW [] synonym: "up regulation of type III hypersensitivity" EXACT [] synonym: "up-regulation of type III hypersensitivity" EXACT [] synonym: "upregulation of type III hypersensitivity" EXACT [] is_a: GO:0001803 ! regulation of type III hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001802 ! type III hypersensitivity relationship: positively_regulates GO:0001802 ! type III hypersensitivity [Term] id: GO:0001806 name: type IV hypersensitivity namespace: biological_process alt_id: GO:0016069 def: "An inflammatory response driven by T cell recognition of processed soluble or cell-associated antigens leading to cytokine release and leukocyte activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "delayed hypersensitivity response" EXACT [] synonym: "delayed-type hypersensitivity" EXACT [] xref: Wikipedia:Type_IV_hypersensitivity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002524 ! hypersensitivity [Term] id: GO:0001807 name: regulation of type IV hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001806 ! type IV hypersensitivity relationship: regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001808 name: negative regulation of type IV hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type IV hypersensitivity" EXACT [] synonym: "down-regulation of type IV hypersensitivity" EXACT [] synonym: "downregulation of type IV hypersensitivity" EXACT [] synonym: "inhibition of type IV hypersensitivity" NARROW [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002884 ! negative regulation of hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001806 ! type IV hypersensitivity relationship: negatively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001809 name: positive regulation of type IV hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type IV hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type IV hypersensitivity" NARROW [] synonym: "stimulation of type IV hypersensitivity" NARROW [] synonym: "up regulation of type IV hypersensitivity" EXACT [] synonym: "up-regulation of type IV hypersensitivity" EXACT [] synonym: "upregulation of type IV hypersensitivity" EXACT [] is_a: GO:0001807 ! regulation of type IV hypersensitivity is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002885 ! positive regulation of hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001806 ! type IV hypersensitivity relationship: positively_regulates GO:0001806 ! type IV hypersensitivity [Term] id: GO:0001810 name: regulation of type I hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type I hypersensitivity, a type of inflammatory response." [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016068 ! type I hypersensitivity relationship: regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001811 name: negative regulation of type I hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of type I hypersensitivity" EXACT [] synonym: "down-regulation of type I hypersensitivity" EXACT [] synonym: "downregulation of type I hypersensitivity" EXACT [] synonym: "inhibition of type I hypersensitivity" NARROW [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016068 ! type I hypersensitivity relationship: negatively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001812 name: positive regulation of type I hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of type I hypersensitivity, a type of inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of type I hypersensitivity" NARROW [] synonym: "stimulation of type I hypersensitivity" NARROW [] synonym: "up regulation of type I hypersensitivity" EXACT [] synonym: "up-regulation of type I hypersensitivity" EXACT [] synonym: "upregulation of type I hypersensitivity" EXACT [] is_a: GO:0001810 ! regulation of type I hypersensitivity is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016068 ! type I hypersensitivity relationship: positively_regulates GO:0016068 ! type I hypersensitivity [Term] id: GO:0001813 name: regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of antibody dependent cell death" EXACT [] synonym: "regulation of antibody dependent cell killing" EXACT [] synonym: "regulation of antibody-dependent cell death" EXACT [] synonym: "regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001796 ! regulation of type IIa hypersensitivity is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001814 name: negative regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "down-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "downregulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "inhibition of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "negative regulation of antibody dependent cell death" EXACT [] synonym: "negative regulation of antibody dependent cell killing" EXACT [] synonym: "negative regulation of antibody-dependent cell death" EXACT [] synonym: "negative regulation of antibody-dependent cell killing" EXACT [] is_a: GO:0001797 ! negative regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: negatively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001815 name: positive regulation of antibody-dependent cellular cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of antibody-dependent cellular cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "positive regulation of antibody dependent cell death" EXACT [] synonym: "positive regulation of antibody dependent cell killing" EXACT [] synonym: "positive regulation of antibody-dependent cell death" EXACT [] synonym: "positive regulation of antibody-dependent cell killing" EXACT [] synonym: "stimulation of antibody-dependent cellular cytotoxicity" NARROW [] synonym: "up regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "up-regulation of antibody-dependent cellular cytotoxicity" EXACT [] synonym: "upregulation of antibody-dependent cellular cytotoxicity" EXACT [] is_a: GO:0001798 ! positive regulation of type IIa hypersensitivity is_a: GO:0001813 ! regulation of antibody-dependent cellular cytotoxicity is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity relationship: positively_regulates GO:0001788 ! antibody-dependent cellular cytotoxicity [Term] id: GO:0001816 name: cytokine production namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. subset: goslim_pir is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0001817 name: regulation of cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001816 ! cytokine production relationship: regulates GO:0001816 ! cytokine production [Term] id: GO:0001818 name: negative regulation of cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of cytokine production" EXACT [] synonym: "down-regulation of cytokine production" EXACT [] synonym: "downregulation of cytokine production" EXACT [] synonym: "inhibition of cytokine production" NARROW [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001816 ! cytokine production relationship: negatively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001819 name: positive regulation of cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of production of a cytokine." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of cytokine production" NARROW [] synonym: "stimulation of cytokine production" NARROW [] synonym: "up regulation of cytokine production" EXACT [] synonym: "up-regulation of cytokine production" EXACT [] synonym: "upregulation of cytokine production" EXACT [] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001816 ! cytokine production relationship: positively_regulates GO:0001816 ! cytokine production [Term] id: GO:0001820 name: serotonin secretion namespace: biological_process def: "The regulated release of serotonin by a cell or group of cells. Serotonin (5-hydroxytryptamine, or 5-HT) is a monoamine synthesised in serotonergic neurons in the central nervous system, enterochromaffin cells in the gastrointestinal tract and some immune system cells." [GOC:ef, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] synonym: "5-HT secretion" EXACT [] synonym: "5-hydroxytryptamine secretion" EXACT [] is_a: GO:0006837 ! serotonin transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0001821 name: histamine secretion namespace: biological_process def: "The regulated release of histamine by a cell or group of cells. It is formed by decarboxylation of histidine and it acts through receptors in smooth muscle and in secretory systems." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0046903 ! secretion is_a: GO:0051608 ! histamine transport [Term] id: GO:0001822 name: kidney development namespace: biological_process def: "The process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and/or excretes the end products of body metabolism in the form of urine." [GOC:dph, GOC:mtg_kidney_jan10, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "nephrogenesis" RELATED [GOC:dph, GOC:tb] xref: Wikipedia:Kidney_development is_a: GO:0048513 ! organ development relationship: part_of GO:0072001 ! renal system development [Term] id: GO:0001823 name: mesonephros development namespace: biological_process def: "The process whose specific outcome is the progression of the mesonephros over time, from its formation to the mature structure. In mammals, the mesonephros is the second of the three embryonic kidneys to be established and exists only transiently. In lower vertebrates such as fish and amphibia, the mesonephros will form the mature kidney." [GOC:dph, ISBN:0124020607, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary", PMID:10535314] is_a: GO:0001822 ! kidney development [Term] id: GO:0001824 name: blastocyst development namespace: biological_process def: "The process whose specific outcome is the progression of the blastocyst over time, from its formation to the mature structure. The mammalian blastocyst is a hollow ball of cells containing two cell types, the inner cell mass and the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS5, embryo ; EMAP:23', 'TS5, inner cell mass ; EMAP:24' and 'TS5, trophectoderm; EMAP:28'. is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001701 ! in utero embryonic development [Term] id: GO:0001825 name: blastocyst formation namespace: biological_process def: "The initial formation of a blastocyst from a solid ball of cells known as a morula." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology term 'TS3, compacted morula ; EMAP:9'. is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001826 name: inner cell mass cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of an inner cell mass cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001827 name: inner cell mass cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become inner cell mass cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, compacted morula ; EMAP:13' and 'TS4, inner cell mass ; EMAP:14'. is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001828 name: inner cell mass cellular morphogenesis namespace: biological_process def: "The morphogenesis of cells in the inner cell mass." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001826 ! inner cell mass cell differentiation [Term] id: GO:0001829 name: trophectodermal cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trophectoderm cell." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001825 ! blastocyst formation [Term] id: GO:0001830 name: trophectodermal cell fate commitment namespace: biological_process def: "The cell fate commitment of precursor cells that will become trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19'. synonym: "trophectoderm cell fate commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001831 name: trophectodermal cellular morphogenesis namespace: biological_process def: "The morphogenesis of trophectoderm cells." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cellular morphogenesis" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001829 ! trophectodermal cell differentiation [Term] id: GO:0001832 name: blastocyst growth namespace: biological_process def: "An increase in size of a blastocyst due to expansion of the blastocoelic cavity cell shape changes and cell proliferation." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, blastocoelic cavity ; EMAP:17', 'TS5, blastocoelic cavity ; EMAP:27' and 'TS6, blastocoelic cavity ; EMAP:36'. is_a: GO:0048589 ! developmental growth relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001833 name: inner cell mass cell proliferation namespace: biological_process def: "The proliferation of cells in the inner cell mass." [GOC:dph, GOC:isa_complete, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, inner cell mass ; EMAP:14' and 'TS5, inner cell mass ; EMAP:24'. is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001834 name: trophectodermal cell proliferation namespace: biological_process def: "The proliferation of cells in the trophectoderm." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, trophectoderm ; EMAP:19', 'TS5, trophectoderm ; EMAP:28' and 'TS6, trophectoderm ; EMAP:39'. synonym: "trophectoderm cell proliferation" EXACT [] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0001832 ! blastocyst growth [Term] id: GO:0001835 name: blastocyst hatching namespace: biological_process def: "The hatching of the cellular blastocyst from the zona pellucida." [GOC:dph, ISBN:0124020607, ISBN:0198542771] comment: See also the Anatomical Dictionary for Mouse Development ontology terms 'TS4, zona pellucida ; EMAP:22' and 'TS5, embryo ; EMAP:23'. is_a: GO:0035188 ! hatching relationship: part_of GO:0001824 ! blastocyst development [Term] id: GO:0001836 name: release of cytochrome c from mitochondria namespace: biological_process def: "The process by which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation." [GOC:add, GOC:mah, ISBN:0721639976, PMID:12925707, PMID:9560217] is_a: GO:0008637 ! apoptotic mitochondrial changes [Term] id: GO:0001837 name: epithelial to mesenchymal transition namespace: biological_process def: "A transition where an epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell." [GOC:dph, PMID:14701881] synonym: "EMT" EXACT [] synonym: "epithelial-mesenchymal transition" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0014031 ! mesenchymal cell development [Term] id: GO:0001838 name: embryonic epithelial tube formation namespace: biological_process def: "The morphogenesis of an embryonic epithelium into a tube-shaped structure." [GOC:dph, ISBN:0824072820] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0072175 ! epithelial tube formation [Term] id: GO:0001839 name: neural plate morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the neural plate are generated and organized. Morphogenesis pertains to the creation of form. The neural plate is a specialized region of columnar epithelial cells in the dorsal ectoderm that will give rise to nervous system tissue." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001840 ! neural plate development [Term] id: GO:0001840 name: neural plate development namespace: biological_process def: "The process whose specific outcome is the progression of the neural plate over time, from its formation to the mature structure. The neural plate is a flat, thickened layer of ectodermal cells. The underlying dorsal mesoderm signals the ectodermal cells above it to elongate into columnar neural plate cells. The neural plate subsequently develops into the neural tube, which gives rise to the central nervous system." [GOC:dph, GOC:ef, ISBN:0878932437, ISBN:0878932585] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0043009 ! chordate embryonic development [Term] id: GO:0001841 name: neural tube formation namespace: biological_process alt_id: GO:0001679 def: "The formation of a tube from the flat layer of ectodermal cells known as the neural plate. This will give rise to the central nervous system." [GOC:dph, ISBN:0878932437] synonym: "neural tube morphogenesis" EXACT [GOC:dph] synonym: "neurulation" EXACT [] xref: Wikipedia:Neurulation is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0021915 ! neural tube development [Term] id: GO:0001842 name: neural fold formation namespace: biological_process def: "The process by which the edges of the neural plate thicken and move up to form a U-shaped structure called the neural groove." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0001839 ! neural plate morphogenesis relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001843 name: neural tube closure namespace: biological_process def: "The last step in the formation of the neural tube, where the paired neural folds are brought together and fuse at the dorsal midline." [GOC:dph, ISBN:0878932437] is_a: GO:0016331 ! morphogenesis of embryonic epithelium is_a: GO:0060606 ! tube closure relationship: part_of GO:0014020 ! primary neural tube formation [Term] id: GO:0001844 name: protein insertion into mitochondrial membrane involved in induction of apoptosis namespace: biological_process def: "The process by which a protein is incorporated into a mitochondrial membrane that contributes to the induction of apoptosis." [GOC:add, PMID:12952892] comment: Note that this term is intended to cover the insertion of pro-apoptotic proteins such as Bax or its homologs into mitochondrial membranes which occurs as an early step in the apoptotic program. synonym: "insertion of proteins into mitochondrial membranes during the induction of apoptosis" EXACT [] synonym: "protein insertion into mitochondrial membrane during induction of apoptosis" RELATED [GOC:dph, GOC:tb] synonym: "protein insertion into mitochondrion membrane during induction of apoptosis" EXACT [] xref: Reactome:114264 "Translocation of activated BAX to the mitochondria" xref: Reactome:139905 "Translocation of activated BAD protein to mitochondria" xref: Reactome:139909 "Translocation of BMF to mitochondria" xref: Reactome:139914 "Translocation of PUMA protein to mitochondria" xref: Reactome:139919 "Translocation of BIM to mitochondria" xref: Reactome:140216 "Translocation of NOXA to mitochondria" xref: Reactome:561740 "Translocation of activated BAD protein to mitochondria" xref: Reactome:561741 "Translocation of activated BAX to the mitochondria" xref: Reactome:561747 "Translocation of BIM to mitochondria" xref: Reactome:561749 "Translocation of BMF to mitochondria" xref: Reactome:561807 "Translocation of PUMA protein to mitochondria" xref: Reactome:587357 "Translocation of activated BAD protein to mitochondria" xref: Reactome:587358 "Translocation of activated BAX to the mitochondria" xref: Reactome:587364 "Translocation of BIM to mitochondria" xref: Reactome:587366 "Translocation of BMF to mitochondria" xref: Reactome:608350 "Translocation of BMF to mitochondria" xref: Reactome:632851 "Translocation of activated BAD protein to mitochondria" xref: Reactome:632853 "Translocation of activated BAX to the mitochondria" is_a: GO:0008637 ! apoptotic mitochondrial changes is_a: GO:0051204 ! protein insertion into mitochondrial membrane relationship: part_of GO:0006917 ! induction of apoptosis [Term] id: GO:0001845 name: phagolysosome assembly namespace: biological_process def: "The process by which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "late phagosome biosynthesis" RELATED [] synonym: "late phagosome formation" RELATED [] synonym: "phagolysosome formation" RELATED [GOC:mah] is_a: GO:0006906 ! vesicle fusion is_a: GO:0006909 ! phagocytosis is_a: GO:0070925 ! organelle assembly [Term] id: GO:0001846 name: opsonin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsonin, such as a complement component or antibody, deposited on the surface of a bacteria, virus, immune complex, or other particulate material." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that an opsonin is a blood serum protein or fragment which when deposited on the surface of a bacteria, virus, immune complex, or other particulate material acts a signal for phagocytosis to cells bearing the appropriate receptors. Not all complement components or fragments and not all antibodies have opsonic properties. is_a: GO:0005515 ! protein binding [Term] id: GO:0001847 name: opsonin receptor activity namespace: molecular_function def: "Combining with an opsonin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0001848 name: complement binding namespace: molecular_function def: "Interacting selectively and non-covalently with any component or product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0005515 ! protein binding [Term] id: GO:0001849 name: complement component C1q binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C1q component of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001850 name: complement component C3a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001851 name: complement component C3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001852 name: complement component iC3b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the iC3b product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001853 name: complement component C3dg binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3dg product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001854 name: complement component C3d binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C3d product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001855 name: complement component C4b binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C4b product of the classical complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001846 ! opsonin binding is_a: GO:0001848 ! complement binding [Term] id: GO:0001856 name: complement component C5a binding namespace: molecular_function def: "Interacting selectively and non-covalently with the C5a product of the complement cascade." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001848 ! complement binding [Term] id: GO:0001857 name: complement component C1q receptor activity namespace: molecular_function def: "Combining with the C1q component of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001849 ! complement component C1q binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001858 name: complement component iC3b receptor activity namespace: molecular_function def: "Combining with the iC3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001852 ! complement component iC3b binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001859 name: complement component C3dg receptor activity namespace: molecular_function def: "Combining with the C3dg product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001860 name: complement component C3d receptor activity namespace: molecular_function def: "Combining with the C3d product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001861 name: complement component C4b receptor activity namespace: molecular_function def: "Combining with the C4b product of the classical complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001855 ! complement component C4b binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0001862 name: collectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a collectin, a member of a group of structurally related pattern recognition molecules characterized by having a carbohydrate recognition domain of the C-type lectin family at the C-terminus and a collagenous domain at the N-terminus." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectins (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001863 name: collectin receptor activity namespace: molecular_function def: "Combining with a collectin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that collectins include such proteins as mannose-binding lectin (MBL) and surfactant proteins A and D (SP-A and SP-D). is_a: GO:0001847 ! opsonin receptor activity [Term] id: GO:0001864 name: pentraxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pentraxin, a member of a family of inflammatory proteins with a radially symmetric arrangement of five identical, noncovalently linked chains in a pentagonal array." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). is_a: GO:0001846 ! opsonin binding [Term] id: GO:0001865 name: NK T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell differentiation" EXACT [] synonym: "natural T cell differentiation" EXACT [] synonym: "NK T lymphocyte differentiation" EXACT [] synonym: "NK T-cell differentiation" EXACT [] synonym: "NK T-lymphocyte differentiation" EXACT [] synonym: "NKT cell differentiation" EXACT [] synonym: "NT cell differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0001866 name: NK T cell proliferation namespace: biological_process def: "The expansion of a NK T cell population by cell division." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:10704459] comment: Note that NK T cells are a distinct lineage of T cells expressing natural killer cell markers and having T cell receptors characterized by the usage of a restricted repertoire of variable region gene segments. synonym: "natural killer T cell proliferation" EXACT [] synonym: "natural T cell proliferation" EXACT [] synonym: "NK T lymphocyte proliferation" EXACT [] synonym: "NK T-cell proliferation" EXACT [] synonym: "NK T-lymphocyte proliferation" EXACT [] synonym: "NKT cell proliferation" EXACT [] synonym: "NT cell proliferation" EXACT [] is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0001867 name: complement activation, lectin pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the lectin pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that proteins such as mannose-binding lectin (MBL) and certain serum ficolins can activate the lectin complement pathway. xref: Reactome:166662 "Lectin pathway of complement activation" xref: Reactome:562783 "Lectin pathway of complement activation" xref: Reactome:588399 "Lectin pathway of complement activation" xref: Reactome:609136 "Lectin pathway of complement activation" is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0001868 name: regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the lectin pathway of complement activation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0030449 ! regulation of complement activation is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001867 ! complement activation, lectin pathway relationship: regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001869 name: negative regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of complement activation, lectin pathway" EXACT [] synonym: "down-regulation of complement activation, lectin pathway" EXACT [] synonym: "downregulation of complement activation, lectin pathway" EXACT [] synonym: "inhibition of complement activation, lectin pathway" NARROW [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045824 ! negative regulation of innate immune response is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001867 ! complement activation, lectin pathway relationship: negatively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001870 name: positive regulation of complement activation, lectin pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of complement activation by the lectin pathway." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of complement activation, lectin pathway" NARROW [] synonym: "stimulation of complement activation, lectin pathway" NARROW [] synonym: "up regulation of complement activation, lectin pathway" EXACT [] synonym: "up-regulation of complement activation, lectin pathway" EXACT [] synonym: "upregulation of complement activation, lectin pathway" EXACT [] is_a: GO:0001868 ! regulation of complement activation, lectin pathway is_a: GO:0045089 ! positive regulation of innate immune response is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001867 ! complement activation, lectin pathway relationship: positively_regulates GO:0001867 ! complement activation, lectin pathway [Term] id: GO:0001871 name: pattern binding namespace: molecular_function def: "Interacting selectively and non-covalently with a repeating or polymeric structure, such as a polysaccharide or peptidoglycan." [PMID:12072369, PMID:12225919, PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for annotation of gene products which function to recognize (bind) the repeating structural units such as polysaccharides or peptidoglycans commonly found in microbial cell walls and virions. If such binding is coupled to signal transduction, use 'pattern recognition receptor activity ; GO:0008329' instead. subset: goslim_pir subset: gosubset_prok synonym: "pattern recognition activity" BROAD [] is_a: GO:0005488 ! binding [Term] id: GO:0001872 name: zymosan binding namespace: molecular_function def: "Interacting selectively and non-covalently with zymosan." [PMID:14707091] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001873 name: polysaccharide receptor activity namespace: molecular_function def: "Combining with a polysaccharide to initiate a change in cell activity." [PMID:14707091] is_a: GO:0008329 ! pattern recognition receptor activity is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0001874 name: zymosan receptor activity namespace: molecular_function def: "Combining with zymosan to initiate a change in cell activity." [PMID:14707091] is_a: GO:0001872 ! zymosan binding is_a: GO:0001873 ! polysaccharide receptor activity [Term] id: GO:0001875 name: lipopolysaccharide receptor activity namespace: molecular_function def: "Combining with a lipopolysaccharide to initiate a change in cell activity. Lipopolysaccharides (LPS) are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system." [PMID:14609719, PMID:15379975] synonym: "endotoxin receptor activity" BROAD [] synonym: "LPS receptor activity" EXACT [] is_a: GO:0001530 ! lipopolysaccharide binding is_a: GO:0008329 ! pattern recognition receptor activity relationship: part_of GO:0031663 ! lipopolysaccharide-mediated signaling pathway [Term] id: GO:0001876 name: lipoarabinomannan binding namespace: molecular_function def: "Interacting selectively and non-covalently with lipoarabinomannan." [PMID:10586073] synonym: "LAM binding" EXACT [] is_a: GO:0001871 ! pattern binding [Term] id: GO:0001877 name: lipoarabinomannan receptor activity namespace: molecular_function def: "Combining with lipoarabinomannan to initiate a change in cell activity." [PMID:10586073] synonym: "LAM receptor activity" EXACT [] is_a: GO:0001876 ! lipoarabinomannan binding is_a: GO:0008329 ! pattern recognition receptor activity [Term] id: GO:0001878 name: response to yeast namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a yeast species." [PMID:14707091] is_a: GO:0009620 ! response to fungus [Term] id: GO:0001879 name: detection of yeast namespace: biological_process def: "The series of events in which a stimulus from a yeast is received and converted into a molecular signal." [PMID:14707091] is_a: GO:0001878 ! response to yeast is_a: GO:0016046 ! detection of fungus [Term] id: GO:0001880 name: Mullerian duct regression namespace: biological_process def: "The process by which the Mullerian ducts, primordia of the oviducts, uterus and upper vagina, undergo regression in male embryos." [GOC:dph, PMID:12368913] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0060033 ! anatomical structure regression relationship: part_of GO:0046661 ! male sex differentiation [Term] id: GO:0001881 name: receptor recycling namespace: biological_process def: "The process by which receptor molecules are returned to an active state and in an active cellular location after they have been stimulated by a ligand. An active state is when the receptor is ready to receive a signal." [GOC:dph] is_a: GO:0023046 ! signaling process is_a: GO:0043112 ! receptor metabolic process [Term] id: GO:0001882 name: nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked either to ribose or deoxyribose." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0001883 name: purine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine nucleoside, a compound consisting of a purine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001884 name: pyrimidine nucleoside binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine nucleoside, a compound consisting of a pyrimidine base linked either to ribose or deoxyribose." [GOC:hjd] is_a: GO:0001882 ! nucleoside binding [Term] id: GO:0001885 name: endothelial cell development namespace: biological_process def: "The progression of an endothelial cell over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0045446 ! endothelial cell differentiation [Term] id: GO:0001886 name: endothelial cell morphogenesis namespace: biological_process def: "The change in form (cell shape and size) that occurs during the differentiation of an endothelial cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis relationship: part_of GO:0001885 ! endothelial cell development [Term] id: GO:0001887 name: selenium metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element selenium or compounds that contain selenium, such as selenocysteine." [PMID:12730456] subset: gosubset_prok synonym: "selenium metabolism" EXACT [] is_a: GO:0006790 ! sulfur metabolic process [Term] id: GO:0001888 name: glucuronyl-galactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan = UDP + alpha-N-acetyl-D-glucosaminyl-(1,4)-beta-D-glucuronosyl-(1,3)-beta-D-galactosyl-(1,3)-beta-D-galactosyl-(1,4)-beta-D-xylosyl-proteoglycan." [EC:2.4.1.223] synonym: "alpha-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "alpha-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.223] synonym: "alpha1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "glucuronosylgalactosyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.223] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-glucuronosyl-(1->3)-beta-D-galactosyl-(1->3)-beta-D-galactosyl-(1->4)-beta-D-xylosyl-proteoglycan 4IV-alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.223] xref: EC:2.4.1.223 xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0001889 name: liver development namespace: biological_process def: "The process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] is_a: GO:0048513 ! organ development relationship: part_of GO:0061008 ! hepaticobiliary system development [Term] id: GO:0001890 name: placenta development namespace: biological_process def: "The process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "placental development" EXACT [] synonym: "placentation" EXACT [GOC:dph, GOC:tb] is_a: GO:0048513 ! organ development [Term] id: GO:0001891 name: phagocytic cup namespace: cellular_component def: "An invagination of the cell membrane formed by an actin dependent process during phagocytosis. Following internalization it is converted into a phagosome." [PMID:10358769] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0001892 name: embryonic placenta development namespace: biological_process def: "The embryonically driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "fetal placenta development" EXACT [GOC:dph] is_a: GO:0048568 ! embryonic organ development relationship: part_of GO:0001701 ! in utero embryonic development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001893 name: maternal placenta development namespace: biological_process def: "Maternally driven process whose specific outcome is the progression of the placenta over time, from its formation to the mature structure. The placenta is an organ of metabolic interchange between fetus and mother, partly of embryonic origin and partly of maternal origin." [GOC:add, ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "decidua development" RELATED [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001890 ! placenta development [Term] id: GO:0001894 name: tissue homeostasis namespace: biological_process def: "A homeostatic process involved in the maintenance of an internal steady-state within a defined tissue of an organism, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:isa_complete] synonym: "tissue maintenance" NARROW [GOC:add] is_a: GO:0060249 ! anatomical structure homeostasis relationship: part_of GO:0048871 ! multicellular organismal homeostasis [Term] id: GO:0001895 name: retina homeostasis namespace: biological_process def: "A tissue homeostatic process involved in the maintenance of an internal equilibrium within the retina of the eye, including control of cellular proliferation and death and control of metabolic function." [GOC:add, GOC:dph, GOC:tb, PMID:15365173, PMID:15365178] is_a: GO:0001894 ! tissue homeostasis [Term] id: GO:0001896 name: autolysis namespace: biological_process def: "The spontaneous death by lysis of bacteria in response to environmental conditions." [GOC:add] subset: gosubset_prok xref: Wikipedia:Autolysis is_a: GO:0019835 ! cytolysis [Term] id: GO:0001897 name: cytolysis by symbiont of host cells namespace: biological_process def: "The killing by an organism of a cell in its host organism by means of the rupture of cell membranes and the loss of cytoplasm. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok synonym: "cytolysis by organism of host cells" EXACT [] is_a: GO:0001907 ! killing by symbiont of host cells is_a: GO:0051801 ! cytolysis of cells in other organism involved in symbiotic interaction is_a: GO:0052025 ! modification by symbiont of host cell membrane [Term] id: GO:0001898 name: regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process by which an organism modulates the frequency, rate or extent of the cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0051802 ! regulation of cytolysis of cells in other organism involved in symbiotic interaction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001899 name: negative regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process by which an organism stops, prevents or reduces the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "down regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "down-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "downregulation by symbiont of cytolysis of host cells" EXACT [] synonym: "inhibition by symbiont of cytolysis of host cells" NARROW [] synonym: "negative regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051803 ! negative regulation of cytolysis of cells in other organism involved in symbiotic interaction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: negatively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001900 name: positive regulation of cytolysis by symbiont of host cells namespace: biological_process def: "Any process by which an organism activates or increases the frequency, rate or extent of cytolysis by that organism of cells in its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "activation by symbiont of cytolysis of host cells" NARROW [] synonym: "positive regulation by symbiont of cytolysis of host cells" EXACT [GOC:dph, GOC:tb] synonym: "stimulation by symbiont of cytolysis of host cells" NARROW [] synonym: "up regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "up-regulation by symbiont of cytolysis of host cells" EXACT [] synonym: "upregulation by symbiont of cytolysis of host cells" EXACT [] is_a: GO:0001898 ! regulation of cytolysis by symbiont of host cells is_a: GO:0051804 ! positive regulation of cytolysis of cells in other organism involved in symbiotic interaction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells relationship: positively_regulates GO:0001897 ! cytolysis by symbiont of host cells [Term] id: GO:0001905 name: activation of membrane attack complex namespace: biological_process def: "The activation of the membrane attack complex components of the complement cascade which can result in death of a target cell through cytolysis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of MAC" EXACT [] synonym: "activation of TCC" NARROW [] synonym: "activation of terminal complement complex" NARROW [GOC:add] synonym: "activation of the terminal complement cascade" NARROW [] synonym: "MAC assembly" EXACT [GOC:rl] synonym: "MAC formation" EXACT [GOC:rl] synonym: "membrane attack complex assembly" EXACT [GOC:rl] synonym: "membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0006956 ! complement activation [Term] id: GO:0001906 name: cell killing namespace: biological_process def: "Any process in an organism that results in the killing of its own cells or those of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions." [GOC:add] subset: goslim_pir subset: gosubset_prok synonym: "necrosis" RELATED [] is_a: GO:0008150 ! biological_process [Term] id: GO:0001907 name: killing by symbiont of host cells namespace: biological_process def: "Any process mediated by an organism that results in the death of cells in the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction." [GOC:add] subset: gosubset_prok is_a: GO:0044004 ! disruption by symbiont of host cells is_a: GO:0051883 ! killing of cells in other organism involved in symbiotic interaction [Term] id: GO:0001909 name: leukocyte mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] comment: This term was improved by GO_REF:0000022. It was moved. Note that this term and its children describe contact-dependent killing of target cells by lymphocytes and myeloid cells of the immune system. synonym: "immune cell mediated cell death" EXACT [] synonym: "immune cell mediated cell killing" EXACT [] synonym: "immune cell mediated cytotoxicity" EXACT [] synonym: "leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001906 ! cell killing is_a: GO:0002252 ! immune effector process [Term] id: GO:0001910 name: regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "regulation of immune cell mediated cell death" EXACT [] synonym: "regulation of immune cell mediated cell killing" EXACT [] synonym: "regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process is_a: GO:0031341 ! regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001911 name: negative regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "down regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "down-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "downregulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "inhibition of leukocyte mediated cytotoxicity" NARROW [] synonym: "negative regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of leucocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0031342 ! negative regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: negatively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001912 name: positive regulation of leukocyte mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of leukocyte mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] synonym: "activation of leukocyte mediated cytotoxicity" NARROW [] synonym: "positive regulation of immune cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of leucocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of leukocyte mediated cytotoxicity" NARROW [] synonym: "up regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "up-regulation of leukocyte mediated cytotoxicity" EXACT [] synonym: "upregulation of leukocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0031343 ! positive regulation of cell killing intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity relationship: positively_regulates GO:0001909 ! leukocyte mediated cytotoxicity [Term] id: GO:0001913 name: T cell mediated cytotoxicity namespace: biological_process def: "The directed killing of a target cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11911826] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in the induction of apoptosis in the target cell. Note that both CD4 and CD8 positive T cells can mediate apoptosis of target cells, independently of their definition as 'helper' T cells or not. synonym: "T cell mediated apoptosis" EXACT [] synonym: "T cell mediated cell death" EXACT [] synonym: "T cell mediated cell killing" EXACT [] synonym: "T cell mediated cytolysis" RELATED [] synonym: "T lymphocyte mediated cytotoxicity" EXACT [] synonym: "T-cell mediated apoptosis" EXACT [] synonym: "T-cell mediated cell death" EXACT [] synonym: "T-cell mediated cell killing" EXACT [] synonym: "T-cell mediated cytotoxicity" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001909 ! leukocyte mediated cytotoxicity is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0001914 name: regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of T cell mediated apoptosis" EXACT [] synonym: "regulation of T cell mediated cell death" EXACT [] synonym: "regulation of T cell mediated cell killing" EXACT [] synonym: "regulation of T cell mediated cytolysis" RELATED [] synonym: "regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "regulation of T-cell mediated apoptosis" EXACT [] synonym: "regulation of T-cell mediated cell death" EXACT [] synonym: "regulation of T-cell mediated cell killing" EXACT [] synonym: "regulation of T-cell mediated cytolysis" RELATED [] synonym: "regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001910 ! regulation of leukocyte mediated cytotoxicity is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001913 ! T cell mediated cytotoxicity relationship: regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001915 name: negative regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of T cell mediated cytotoxicity" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity" NARROW [] synonym: "negative regulation of T cell mediated apoptosis" EXACT [] synonym: "negative regulation of T cell mediated cell death" EXACT [] synonym: "negative regulation of T cell mediated cell killing" EXACT [] synonym: "negative regulation of T cell mediated cytolysis" RELATED [] synonym: "negative regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-cell mediated apoptosis" EXACT [] synonym: "negative regulation of T-cell mediated cell death" EXACT [] synonym: "negative regulation of T-cell mediated cell killing" EXACT [] synonym: "negative regulation of T-cell mediated cytolysis" RELATED [] synonym: "negative regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated cytotoxicity" EXACT [] is_a: GO:0001911 ! negative regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002710 ! negative regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity relationship: negatively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001916 name: positive regulation of T cell mediated cytotoxicity namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of T cell mediated cytotoxicity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of T cell mediated cytotoxicity" NARROW [] synonym: "positive regulation of T cell mediated apoptosis" EXACT [] synonym: "positive regulation of T cell mediated cell death" EXACT [] synonym: "positive regulation of T cell mediated cell killing" EXACT [] synonym: "positive regulation of T cell mediated cytolysis" RELATED [] synonym: "positive regulation of T lymphocyte mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-cell mediated apoptosis" EXACT [] synonym: "positive regulation of T-cell mediated cell death" EXACT [] synonym: "positive regulation of T-cell mediated cell killing" EXACT [] synonym: "positive regulation of T-cell mediated cytolysis" RELATED [] synonym: "positive regulation of T-cell mediated cytotoxicity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated cytotoxicity" EXACT [] synonym: "stimulation of T cell mediated cytotoxicity" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity" EXACT [] is_a: GO:0001912 ! positive regulation of leukocyte mediated cytotoxicity is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002711 ! positive regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001913 ! T cell mediated cytotoxicity relationship: positively_regulates GO:0001913 ! T cell mediated cytotoxicity [Term] id: GO:0001917 name: photoreceptor inner segment namespace: cellular_component def: "The inner segment of a vertebrate photoreceptor containing mitochondria, ribosomes and membranes where opsin molecules are assembled and passed to be part of the outer segment discs." [GOC:add, PMID:12019563] subset: goslim_pir is_a: GO:0044464 ! cell part [Term] id: GO:0001918 name: farnesylated protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a farnesylated protein." [GOC:add, PMID:14555765] is_a: GO:0005515 ! protein binding [Term] id: GO:0001919 name: regulation of receptor recycling namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of receptor recycling." [GOC:add] is_a: GO:0023051 ! regulation of signaling process is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001881 ! receptor recycling relationship: regulates GO:0001881 ! receptor recycling [Term] id: GO:0001920 name: negative regulation of receptor recycling namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of receptor recycling." [GOC:add] synonym: "down regulation of receptor recycling" EXACT [] synonym: "down-regulation of receptor recycling" EXACT [] synonym: "downregulation of receptor recycling" EXACT [] synonym: "inhibition of receptor recycling" NARROW [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0023057 ! negative regulation of signaling process is_a: GO:0031324 ! negative regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001881 ! receptor recycling relationship: negatively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001921 name: positive regulation of receptor recycling namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor recycling." [GOC:add] synonym: "activation of receptor recycling" NARROW [] synonym: "stimulation of receptor recycling" NARROW [] synonym: "up regulation of receptor recycling" EXACT [] synonym: "up-regulation of receptor recycling" EXACT [] synonym: "upregulation of receptor recycling" EXACT [] is_a: GO:0001919 ! regulation of receptor recycling is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0023056 ! positive regulation of signaling process is_a: GO:0031325 ! positive regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001881 ! receptor recycling relationship: positively_regulates GO:0001881 ! receptor recycling [Term] id: GO:0001922 name: B-1 B cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of B cells of the B-1 subset such that the total number of B-1 B cells within a whole or part of an organism is stable over time in the absence of an outside stimulus. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that this term represents the return of B-1 B cell levels to stable numbers following an immune response, as well as the proliferation and elimination of B-1 B cells in a organism required to maintain stable numbers in the absence of an outside stimulus. synonym: "B-1 B lymphocyte homeostasis" EXACT [] synonym: "B-1 B-cell homeostasis" EXACT [] synonym: "B-1 B-lymphocyte homeostasis" EXACT [] is_a: GO:0001782 ! B cell homeostasis [Term] id: GO:0001923 name: B-1 B cell differentiation namespace: biological_process def: "The process whereby a hemopoietic stem cell acquires the specialized features of a B-1 B cell. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1 B lymphocyte differentiation" EXACT [] synonym: "B-1 B-cell differentiation" EXACT [] synonym: "B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0001924 name: regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B-1 B cell differentiation. B-1 B cells are a distinct subset of B cells characterized as being CD5 positive, found predominantly in the peritoneum, pleural cavities, and spleen, and enriched for self-reactivity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "regulation of B-1 B-cell differentiation" EXACT [] synonym: "regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001923 ! B-1 B cell differentiation relationship: regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001925 name: negative regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "down regulation of B-1 B cell differentiation" EXACT [] synonym: "down-regulation of B-1 B cell differentiation" EXACT [] synonym: "downregulation of B-1 B cell differentiation" EXACT [] synonym: "inhibition of B-1 B cell differentiation" NARROW [] synonym: "negative regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "negative regulation of B-1 B-cell differentiation" EXACT [] synonym: "negative regulation of B-1 B-lymphocyte differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045578 ! negative regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001923 ! B-1 B cell differentiation relationship: negatively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001926 name: positive regulation of B-1 B cell differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of B-1 B cell differentiation." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of B-1 B cell differentiation" NARROW [] synonym: "positive regulation of B-1 B lymphocyte differentiation" EXACT [] synonym: "positive regulation of B-1 B-cell differentiation" EXACT [] synonym: "positive regulation of B-1 B-lymphocyte differentiation" EXACT [] synonym: "stimulation of B-1 B cell differentiation" NARROW [] synonym: "up regulation of B-1 B cell differentiation" EXACT [] synonym: "up-regulation of B-1 B cell differentiation" EXACT [] synonym: "upregulation of B-1 B cell differentiation" EXACT [] is_a: GO:0001924 ! regulation of B-1 B cell differentiation is_a: GO:0045579 ! positive regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001923 ! B-1 B cell differentiation relationship: positively_regulates GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0001927 name: exocyst assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of various polypeptides into the exocyst complex." [GOC:hjd, Wikipedia:Exocyst] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006904 ! vesicle docking involved in exocytosis [Term] id: GO:0001928 name: regulation of exocyst assembly namespace: biological_process def: "Any process that modulates the frequency, rate or extent of exocyst assembly." [GOC:hjd] comment: Note that the assembly is regulated by several small GTPases of the Rab and Rho families. is_a: GO:0017157 ! regulation of exocytosis is_a: GO:0043254 ! regulation of protein complex assembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001927 ! exocyst assembly relationship: regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001929 name: negative regulation of exocyst assembly namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of exocyst assembly." [GOC:hjd] synonym: "down regulation of exocyst assembly" EXACT [] synonym: "down-regulation of exocyst assembly" EXACT [] synonym: "downregulation of exocyst assembly" EXACT [] synonym: "inhibition of exocyst assembly" NARROW [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031333 ! negative regulation of protein complex assembly is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001927 ! exocyst assembly relationship: negatively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001930 name: positive regulation of exocyst assembly namespace: biological_process def: "Any process that increases the rate or extent of exocyst assembly." [GOC:hjd] synonym: "activation of exocyst assembly" NARROW [] synonym: "stimulation of exocyst assembly" NARROW [] synonym: "up regulation of exocyst assembly" EXACT [] synonym: "up-regulation of exocyst assembly" EXACT [] synonym: "upregulation of exocyst assembly" EXACT [] is_a: GO:0001928 ! regulation of exocyst assembly is_a: GO:0031334 ! positive regulation of protein complex assembly is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001927 ! exocyst assembly relationship: positively_regulates GO:0001927 ! exocyst assembly [Term] id: GO:0001931 name: uropod namespace: cellular_component def: "A membrane projection with related cytoskeletal components at the trailing edge of a cell in the process of migrating or being activated, found on the opposite side of the cell from the leading edge or immunological synapse, respectively." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12714569, PMID:12787750] synonym: "distal pole complex" RELATED [] synonym: "retractile pole" RELATED [] synonym: "uropodium" EXACT [] is_a: GO:0042995 ! cell projection intersection_of: GO:0042995 ! cell projection intersection_of: part_of GO:0031254 ! trailing edge relationship: part_of GO:0031254 ! trailing edge [Term] id: GO:0001932 name: regulation of protein amino acid phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of addition of phosphate groups into an amino acid in a protein." [GOC:hjd] subset: gosubset_prok is_a: GO:0031399 ! regulation of protein modification process is_a: GO:0042325 ! regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006468 ! protein amino acid phosphorylation relationship: regulates GO:0006468 ! protein amino acid phosphorylation [Term] id: GO:0001933 name: negative regulation of protein amino acid phosphorylation namespace: biological_process def: "Any process that stops, prevents or decreases the rate of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "down regulation of protein amino acid phosphorylation" EXACT [] synonym: "down-regulation of protein amino acid phosphorylation" EXACT [] synonym: "downregulation of protein amino acid phosphorylation" EXACT [] synonym: "inhibition of protein amino acid phosphorylation" NARROW [] is_a: GO:0001932 ! regulation of protein amino acid phosphorylation is_a: GO:0031400 ! negative regulation of protein modification process is_a: GO:0042326 ! negative regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006468 ! protein amino acid phosphorylation relationship: negatively_regulates GO:0006468 ! protein amino acid phosphorylation [Term] id: GO:0001934 name: positive regulation of protein amino acid phosphorylation namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of addition of phosphate groups to amino acids within a protein." [GOC:hjd] subset: gosubset_prok synonym: "activation of protein amino acid phosphorylation" NARROW [] synonym: "stimulation of protein amino acid phosphorylation" NARROW [] synonym: "up regulation of protein amino acid phosphorylation" EXACT [] synonym: "up-regulation of protein amino acid phosphorylation" EXACT [] synonym: "upregulation of protein amino acid phosphorylation" EXACT [] is_a: GO:0001932 ! regulation of protein amino acid phosphorylation is_a: GO:0031401 ! positive regulation of protein modification process is_a: GO:0042327 ! positive regulation of phosphorylation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006468 ! protein amino acid phosphorylation relationship: positively_regulates GO:0006468 ! protein amino acid phosphorylation [Term] id: GO:0001935 name: endothelial cell proliferation namespace: biological_process def: "The multiplication or reproduction of endothelial cells, resulting in the expansion of a cell population. Endothelial cells are thin flattened cells which line the inside surfaces of body cavities, blood vessels, and lymph vessels, making up the endothelium." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0001936 name: regulation of endothelial cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of endothelial cell proliferation." [GOC:add] is_a: GO:0042127 ! regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001935 ! endothelial cell proliferation relationship: regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001937 name: negative regulation of endothelial cell proliferation namespace: biological_process def: "Any process that stops, prevents, or reduces the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "down regulation of endothelial cell proliferation" EXACT [] synonym: "down-regulation of endothelial cell proliferation" EXACT [] synonym: "downregulation of endothelial cell proliferation" EXACT [] synonym: "inhibition of endothelial cell proliferation" NARROW [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0008285 ! negative regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001935 ! endothelial cell proliferation relationship: negatively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001938 name: positive regulation of endothelial cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of endothelial cell proliferation." [GOC:add] synonym: "activation of endothelial cell proliferation" NARROW [] synonym: "stimulation of endothelial cell proliferation" NARROW [] synonym: "up regulation of endothelial cell proliferation" EXACT [] synonym: "up-regulation of endothelial cell proliferation" EXACT [] synonym: "upregulation of endothelial cell proliferation" EXACT [] is_a: GO:0001936 ! regulation of endothelial cell proliferation is_a: GO:0008284 ! positive regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001935 ! endothelial cell proliferation relationship: positively_regulates GO:0001935 ! endothelial cell proliferation [Term] id: GO:0001939 name: female pronucleus namespace: cellular_component def: "The pronucleus originating from the ovum that is being fertilized." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001940 name: male pronucleus namespace: cellular_component def: "The pronucleus originating from the spermatozoa that was involved in fertilization." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0045120 ! pronucleus [Term] id: GO:0001941 name: postsynaptic membrane organization namespace: biological_process def: "The maintenance of membrane composition in a postsynaptic membrane, the specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft)." [GOC:dph] synonym: "postsynaptic membrane organisation" EXACT [GOC:curators] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0001942 name: hair follicle development namespace: biological_process alt_id: GO:0001943 def: "The process whose specific outcome is the progression of the hair follicle over time, from its formation to the mature structure. A hair follicle is a tube-like opening in the epidermis where the hair shaft develops and into which the sebaceous glands open." [GOC:dph, http://cancerweb.ncl.ac.uk] is_a: GO:0008544 ! epidermis development is_a: GO:0022405 ! hair cycle process [Term] id: GO:0001944 name: vasculature development namespace: biological_process def: "The process whose specific outcome is the progression of the vasculature over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0048513 ! organ development [Term] id: GO:0001945 name: lymph vessel development namespace: biological_process def: "The process whose specific outcome is the progression of the lymphatic vasculature over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001944 ! vasculature development [Term] id: GO:0001946 name: lymphangiogenesis namespace: biological_process def: "Lymph vessel formation when new vessels emerge from the proliferation of pre-existing vessels." [GOC:dph, PMID:11596157] synonym: "lymph vessel formation" EXACT systematic_synonym [] xref: Wikipedia:Lymphangiogenesis is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0001945 ! lymph vessel development [Term] id: GO:0001947 name: heart looping namespace: biological_process def: "The characteristic morphogenetic movements where the primitive heart tube loops asymmetrically. This looping brings the primitive heart chambers into alignment preceding their future integration." [GOC:dph, PMID:12094232] synonym: "cardiac looping" EXACT [] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis [Term] id: GO:0001948 name: glycoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with a glycoprotein, a protein that contains covalently bound glycose (monosaccharide) residues. These also include proteoglycans." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0001949 name: sebaceous gland cell differentiation namespace: biological_process def: "Process whereby a relatively unspecialized epidermal cell acquires the specialized features of a sebaceous gland cell." [GOC:mgi_curators, PMID:15737203] synonym: "sebocytes differentiation" NARROW [GOC:mgi_curators] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0048733 ! sebaceous gland development [Term] id: GO:0001950 name: plasma membrane enriched fraction namespace: cellular_component def: "The fraction of cells, prepared by disruptive biochemical methods, that is enriched for plasma membranes." [GOC:mgi_curators, PMID:11562363, PMID:15601832] synonym: "PME fraction" RELATED [GOC:mah] is_a: GO:0000267 ! cell fraction relationship: part_of GO:0005624 ! membrane fraction [Term] id: GO:0001951 name: intestinal D-glucose absorption namespace: biological_process def: "Uptake of D-glucose into the blood by absorption from the small intestine." [GOC:mgi_curators, PMID:5601832] is_a: GO:0015758 ! glucose transport is_a: GO:0050892 ! intestinal absorption [Term] id: GO:0001952 name: regulation of cell-matrix adhesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to the extracellular matrix." [GOC:hjd] is_a: GO:0010810 ! regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007160 ! cell-matrix adhesion relationship: regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001953 name: negative regulation of cell-matrix adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell adhesion to the extracellular matrix." [GOC:hjd] synonym: "down regulation of cell-matrix adhesion" EXACT [] synonym: "down-regulation of cell-matrix adhesion" EXACT [] synonym: "downregulation of cell-matrix adhesion" EXACT [] synonym: "inhibition of cell-matrix adhesion" NARROW [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010812 ! negative regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007160 ! cell-matrix adhesion relationship: negatively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001954 name: positive regulation of cell-matrix adhesion namespace: biological_process def: "Any process that activates or increases the rate or extent of cell adhesion to an extracellular matrix." [GOC:hjd] synonym: "activation of cell-matrix adhesion" NARROW [] synonym: "stimulation of cell-matrix adhesion" NARROW [] synonym: "up regulation of cell-matrix adhesion" EXACT [] synonym: "up-regulation of cell-matrix adhesion" EXACT [] synonym: "upregulation of cell-matrix adhesion" EXACT [] is_a: GO:0001952 ! regulation of cell-matrix adhesion is_a: GO:0010811 ! positive regulation of cell-substrate adhesion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007160 ! cell-matrix adhesion relationship: positively_regulates GO:0007160 ! cell-matrix adhesion [Term] id: GO:0001955 name: blood vessel maturation namespace: biological_process def: "A developmental process, independent of morphogenetic (shape) change, that is required for a blood vessel to attain its fully functional state." [GOC:dph] is_a: GO:0071695 ! anatomical structure maturation relationship: part_of GO:0001568 ! blood vessel development [Term] id: GO:0001956 name: positive regulation of neurotransmitter secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the regulated release of a neurotransmitter." [GOC:hjd] synonym: "activation of neurotransmitter secretion" NARROW [] synonym: "stimulation of neurotransmitter secretion" NARROW [] synonym: "up regulation of neurotransmitter secretion" EXACT [] synonym: "up-regulation of neurotransmitter secretion" EXACT [] synonym: "upregulation of neurotransmitter secretion" EXACT [] is_a: GO:0046928 ! regulation of neurotransmitter secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051590 ! positive regulation of neurotransmitter transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007269 ! neurotransmitter secretion relationship: positively_regulates GO:0007269 ! neurotransmitter secretion [Term] id: GO:0001957 name: intramembranous ossification namespace: biological_process def: "The formation of bone in which osteoblasts secrete a collagen-proteoglycan matrix that binds calcium salts and becomes calcified. Intramembranous ossification is the way flat bones and the shell of a turtle are formed." [ISBN:0878932437] xref: Wikipedia:Intramembranous_ossification is_a: GO:0001503 ! ossification [Term] id: GO:0001958 name: endochondral ossification namespace: biological_process def: "The formation of bone by the replacement of cartilage tissue with mineralized bone." [ISBN:0878932437] xref: Wikipedia:Endochondral_ossification is_a: GO:0001503 ! ossification relationship: part_of GO:0060350 ! endochondral bone morphogenesis [Term] id: GO:0001959 name: regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001960 name: negative regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the cytokine mediated signaling pathway." [GOC:hjd] synonym: "down regulation of cytokine mediated signaling pathway" EXACT [] synonym: "down-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "downregulation of cytokine mediated signaling pathway" EXACT [] synonym: "inhibition of cytokine mediated signaling pathway" NARROW [] synonym: "negative regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "negative regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "negative regulation of cytokine mediated signalling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0035467 ! negative regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: negatively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001961 name: positive regulation of cytokine-mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of a cytokine mediated signaling pathway." [GOC:hjd] synonym: "activation of cytokine mediated signaling pathway" NARROW [] synonym: "positive regulation of cytokine and chemokine mediated signaling pathway" EXACT [] synonym: "positive regulation of cytokine mediated signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of cytokine mediated signalling pathway" EXACT [] synonym: "stimulation of cytokine mediated signaling pathway" NARROW [] synonym: "up regulation of cytokine mediated signaling pathway" EXACT [] synonym: "up-regulation of cytokine mediated signaling pathway" EXACT [] synonym: "upregulation of cytokine mediated signaling pathway" EXACT [] is_a: GO:0001959 ! regulation of cytokine-mediated signaling pathway is_a: GO:0035468 ! positive regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway relationship: positively_regulates GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0001962 name: alpha-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,3-linkage." [GOC:hjd, PMID:10854427] synonym: "isoglobotriaosylceramide synthase" NARROW [] xref: EC:2.4.1.- is_a: GO:0008378 ! galactosyltransferase activity [Term] id: GO:0001963 name: synaptic transmission, dopaminergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine." [GOC:dph] is_a: GO:0007270 ! nerve-nerve synaptic transmission [Term] id: GO:0001964 name: startle response namespace: biological_process def: "An action or movement due to the application of a sudden unexpected stimulus." [GOC:dph] xref: Wikipedia:Startle_reaction is_a: GO:0009605 ! response to external stimulus is_a: GO:0050905 ! neuromuscular process [Term] id: GO:0001965 name: G-protein alpha-subunit binding namespace: molecular_function def: "Interacting selectively and non-covalently with a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide." [GOC:hjd] synonym: "G-alpha protein subunit binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0001966 name: thigmotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to touch." [GOC:dph] synonym: "stereotaxis" EXACT [] synonym: "taxis in response to mechanical stimulus" BROAD [] synonym: "taxis in response to touch stimulus" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0001967 name: suckling behavior namespace: biological_process def: "Specific actions of a newborn or infant mammal that result in the derivation of nourishment from the breast." [GOC:dph] synonym: "nursing behavior" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0001968 name: fibronectin binding namespace: molecular_function def: "Interacting selectively and non-covalently with a fibronectin, a group of related adhesive glycoproteins of high molecular weight found on the surface of animal cells, connective tissue matrices, and in extracellular fluids." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0001969 name: regulation of activation of membrane attack complex namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "regulation of activation of MAC" EXACT [GOC:mah] synonym: "regulation of activation of TCC" NARROW [GOC:mah] synonym: "regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "regulation of MAC assembly" EXACT [GOC:rl] synonym: "regulation of MAC formation" EXACT [GOC:rl] synonym: "regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0030449 ! regulation of complement activation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001905 ! activation of membrane attack complex relationship: regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001970 name: positive regulation of activation of membrane attack complex namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "activation of activation of membrane attack complex" NARROW [] synonym: "positive regulation of activation of MAC" EXACT [GOC:mah] synonym: "positive regulation of activation of TCC" NARROW [GOC:mah] synonym: "positive regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "positive regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "positive regulation of MAC assembly" EXACT [GOC:rl] synonym: "positive regulation of MAC formation" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "positive regulation of membrane attack complex formation" EXACT [GOC:rl] synonym: "stimulation of activation of membrane attack complex" NARROW [] synonym: "up regulation of activation of membrane attack complex" EXACT [] synonym: "up-regulation of activation of membrane attack complex" EXACT [] synonym: "upregulation of activation of membrane attack complex" EXACT [] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045917 ! positive regulation of complement activation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001905 ! activation of membrane attack complex relationship: positively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001971 name: negative regulation of activation of membrane attack complex namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the activation of the membrane attack complex components of the complement cascade." [GOC:hjd] synonym: "down regulation of activation of membrane attack complex" EXACT [] synonym: "down-regulation of activation of membrane attack complex" EXACT [] synonym: "downregulation of activation of membrane attack complex" EXACT [] synonym: "inhibition of activation of membrane attack complex" NARROW [] synonym: "negative regulation of activation of MAC" EXACT [GOC:mah] synonym: "negative regulation of activation of TCC" NARROW [GOC:mah] synonym: "negative regulation of activation of terminal complement complex" NARROW [GOC:add] synonym: "negative regulation of activation of the terminal complement cascade" NARROW [GOC:mah] synonym: "negative regulation of MAC assembly" EXACT [GOC:rl] synonym: "negative regulation of MAC formation" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex assembly" EXACT [GOC:rl] synonym: "negative regulation of membrane attack complex formation" EXACT [GOC:rl] is_a: GO:0001969 ! regulation of activation of membrane attack complex is_a: GO:0045916 ! negative regulation of complement activation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001905 ! activation of membrane attack complex relationship: negatively_regulates GO:0001905 ! activation of membrane attack complex [Term] id: GO:0001972 name: retinoic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid." [GOC:hjd] is_a: GO:0005501 ! retinoid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0001973 name: adenosine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an adenosine receptor binding to one of its physiological ligands." [GOC:dph] synonym: "adenosine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0001974 name: blood vessel remodeling namespace: biological_process def: "The reorganization or renovation of existing blood vessels." [GOC:hjd] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0048514 ! blood vessel morphogenesis [Term] id: GO:0001975 name: response to amphetamine namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amphetamine stimulus. Amphetamines consist of a group of compounds related to alpha-methylphenethylamine." [ChEBI:2679, GOC:dph, GOC:ef] is_a: GO:0014075 ! response to amine stimulus [Term] id: GO:0001976 name: neurological system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The regulation of blood pressure mediated by detection of stimuli and a neurological response." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by neurological process" EXACT [] synonym: "fast control of arterial pressure" RELATED [] synonym: "neurological process involved in regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0001977 name: renal system process involved in regulation of blood volume namespace: biological_process def: "A slow mechanism of blood pressure regulation that responds to changes in pressure resulting from fluid and salt intake by modulating the quantity of blood in the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renal blood volume control of blood pressure" RELATED [] synonym: "renal regulation of blood volume" RELATED [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0050878 ! regulation of body fluid levels [Term] id: GO:0001978 name: regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in large arteries and responding to the input via central nervous system control." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "baroreceptor feedback control of blood pressure" RELATED [] synonym: "baroreceptor pressure buffer system" RELATED [ISBN:068340007X "Stedman's Medical Dictionary"] synonym: "carotid sinus baroreceptor feedback regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0001979 name: regulation of systemic arterial blood pressure by chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid and aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "chemoreceptor control of blood pressure" RELATED [] synonym: "chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "regulation of systemic arterial blood pressure by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001980 name: regulation of systemic arterial blood pressure by ischemic conditions namespace: biological_process def: "The process that modulates blood pressure by the detection of carbon dioxide levels in the brain stem. Increased levels activate the sympathetic vasoconstrictor mechanism increasing the force with which blood flows through the circulatory system." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "CNS ischemic response" RELATED [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "ischemic control of blood pressure" RELATED [] synonym: "ischemic regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0001981 name: baroreceptor detection of arterial stretch namespace: biological_process def: "The series of events by which the change in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003018 ! vascular process in circulatory system is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0001982 name: baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "The lowering of the number of nerve impulses from baroreceptors as a result of decreased stretch of an artery that results in an increased in sympathetic nerve impulses to peripheral blood vessels." [GOC:dph, GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0001983 name: baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "The increase in nerve impulses from baroreceptors as a result of increased pressure on an artery that results in an inhibition of sympathetic nerve impulses to peripheral blood vessels." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology", ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0001984 name: vasodilation of artery involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "An increase in the internal diameter of an artery, triggered by vasomotor suppression, during the chemoreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001985 name: negative regulation of heart rate involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of heart contraction as a result of the baroreceptor response to increased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "down regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "down-regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "downregulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "inhibition of heart contraction rate in baroreceptor response to increased blood pressure" NARROW [] synonym: "negative control of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] synonym: "negative regulation of cardiac contraction rate in baroreceptor response to increased blood pressure" RELATED [] synonym: "negative regulation of heart contraction rate in baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001986 name: negative regulation of the force of heart contraction involved in baroreceptor response to increased systemic arterial blood pressure namespace: biological_process def: "Any process that decreases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the baroreceptor response to increased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "decreased force of heart contraction during baroreceptor response to increased systemic arterial blood pressure" EXACT [] synonym: "decreased strength of cardiac contraction during baroreceptor response to increased blood pressure" EXACT [] is_a: GO:0045822 ! negative regulation of heart contraction relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0001987 name: vasoconstriction of artery involved in baroreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001988 name: positive regulation of heart rate in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of heart contraction as a result of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "activation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "positive control of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of cardiac contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "positive regulation of heart contraction rate in baroreceptor response to decreased blood pressure" RELATED [] synonym: "stimulation of heart contraction rate in baroreceptor response to decreased blood pressure" NARROW [] synonym: "up regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "up-regulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] synonym: "upregulation of heart contraction rate in baroreceptor response to decreased blood pressure" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001989 name: positive regulation of the force of heart contraction involved in baroreceptor response to decreased systemic arterial blood pressure namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as part of the baroreceptor response to decreased blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "increased force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [] synonym: "increased strength of cardiac contraction during baroreceptor response to decreased blood pressure" RELATED [] synonym: "positive regulation of the force of heart contraction during baroreceptor response to decreased systemic arterial blood pressure" RELATED [GOC:tb] is_a: GO:0045823 ! positive regulation of heart contraction relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0001990 name: regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process by which hormones modulate the force with which blood passes through the circulatory system. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by hormone" EXACT [] synonym: "hormonal control of blood pressure" RELATED [] synonym: "hormonal regulation of blood pressure" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal is_a: GO:0050886 ! endocrine process [Term] id: GO:0001991 name: regulation of systemic arterial blood pressure by circulatory renin-angiotensin namespace: biological_process def: "The process by which angiotensinogen metabolites in the bloodstream modulate the force with which blood passes through the circulatory system. The process begins when renin is released and cleaves angiotensinogen." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "circulatory renin-angiotensin blood pressure regulation" EXACT [] synonym: "circulatory renin-angiotensin control of blood pressure" RELATED [] synonym: "circulatory renin-angiotensin regulation of blood pressure" EXACT [] synonym: "control of blood pressure by circulatory renin-angiotensin" RELATED [] synonym: "renin-angiotensin blood pressure control" RELATED [] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0001992 name: regulation of systemic arterial blood pressure by vasopressin namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule vasopressin. Vasopressin is produced in the hypothalamus, and affects vasoconstriction, and renal water transport." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by vasopressin" EXACT [] synonym: "vasopressin control of blood pressure" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0001993 name: regulation of systemic arterial blood pressure by norepinephrine-epinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine or epinephrine into the bloodstream modulates the force with which blood passes through the circulatory system." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "noradrenaline-adrenaline regulation of blood pressure" RELATED [] synonym: "norepinephrine-epinephrine blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine blood pressure regulation" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0001994 name: norepinephrine-epinephrine vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in a decrease in the diameter of an artery during the norepinephrine-epinephrine response to decreased blood pressure." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "noradrenaline-adrenaline vasoconstriction involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure control" RELATED [] synonym: "norepinephrine-epinephrine vasoconstriction during blood pressure regulation" EXACT [] synonym: "norepinephrine-epinephrine vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001995 name: norepinephrine-epinephrine catabolic process in blood stream namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of norepinephrine or epinephrine in the bloodstream." [GOC:hjd] synonym: "noradrenaline-adrenalin catabolic process in blood stream" EXACT [] is_a: GO:0042419 ! epinephrine catabolic process relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0001996 name: positive regulation of heart rate by epinephrine-norepinephrine namespace: biological_process def: "The process by which the presence of epinephrine or norepinephrine in the bloodstream activates, maintains or increases the rate of heart contraction." [GOC:dph] synonym: "activation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "increased chronotropy by epinephrine-norepinephrine" RELATED [] synonym: "positive control of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "positive regulation of cardiac contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction rate by adrenaline-noradrenaline" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine-norepinephrine" RELATED [] synonym: "stimulation of heart contraction rate by epinephrine-norepinephrine" NARROW [] synonym: "up regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "up-regulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] synonym: "upregulation of heart contraction rate by epinephrine-norepinephrine" EXACT [] is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001997 name: positive regulation of the force of heart contraction by epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream or released from the nerve endings." [GOC:dph, GOC:mtg_cardio] synonym: "increased force of heart contraction by adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by epinephrine-norepinephrine" EXACT [] synonym: "increased inotropy by epinephrine-norepinephrine " RELATED [] synonym: "increased strength of cardiac contraction by epinephrine-norepinephrine" EXACT [] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003321 ! positive regulation of blood pressure by epinephrine-norepinephrine [Term] id: GO:0001998 name: angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of angiotensin into the blood stream." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "angiotensin mediated vasoconstriction during blood pressure control" RELATED [] synonym: "angiotensin mediated vasoconstriction during blood pressure regulation" EXACT [] synonym: "angiotensin mediated vasoconstriction during control of blood pressure" RELATED [] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0001999 name: renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure namespace: biological_process def: "The physiological response of the kidneys to a decrease in blood flow." [GOC:dph] synonym: "renal response to blood flow during renin-angiotensin control of blood pressure" RELATED [] is_a: GO:0003014 ! renal system process relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002000 name: detection of renal blood flow namespace: biological_process def: "The process by which the juxtaglomerular cells of the kidneys receive information about the amount of blood flowing through the arterioles and converts the information to a molecular signal." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0050982 ! detection of mechanical stimulus relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002001 name: renin secretion into blood stream namespace: biological_process def: "The regulated release of renin into the blood stream by juxtoglomerular cells." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin release into blood stream" EXACT [] is_a: GO:0009306 ! protein secretion relationship: part_of GO:0001999 ! renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure [Term] id: GO:0002002 name: regulation of angiotensin levels in blood namespace: biological_process def: "The process that modulates the level of angiotensin in the blood by balancing the maturation of renin substrate to mature angiotensin and the catabolism of mature angiotensin." [GOC:dph] synonym: "control of angiotensin levels in blood" RELATED [] synonym: "control of blood angiotensin level" RELATED [] synonym: "regulation of blood angiotensin level" EXACT [] is_a: GO:0010817 ! regulation of hormone levels is_a: GO:0060177 ! regulation of angiotensin metabolic process relationship: part_of GO:0001991 ! regulation of systemic arterial blood pressure by circulatory renin-angiotensin [Term] id: GO:0002003 name: angiotensin maturation namespace: biological_process def: "The process leading to the attainment of the full functional capacity of angiotensin by conversion of renin substrate into mature angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0016486 ! peptide hormone processing relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002004 name: secretion of vasopressin involved in fast regulation of systemic arterial blood pressure namespace: biological_process def: "The regulated release of the hormone vasopressin into the blood stream by the hypothalamus and pituitary gland contributing to fast regulation of blood pressure." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "secretion of vasopressin during fast control of blood pressure" RELATED [] synonym: "secretion of vasopressin during fast regulation of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0030103 ! vasopressin secretion relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002005 name: angiotensin catabolic process in blood namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of angiotensin in the blood." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0044254 ! multicellular organismal protein catabolic process relationship: part_of GO:0002002 ! regulation of angiotensin levels in blood [Term] id: GO:0002006 name: vasoconstriction by vasopressin involved in systemic arterial blood pressure control namespace: biological_process def: "The decrease in blood vessel diameter as a result of the release of vasopressin into the blood stream." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "vasopressin mediated vasoconstriction involved in systemic arterial blood pressure control" EXACT [GOC:dph, GOC:tb] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001992 ! regulation of systemic arterial blood pressure by vasopressin [Term] id: GO:0002007 name: detection of hypoxic conditions in blood by chemoreceptor signaling namespace: biological_process def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:dph] synonym: "detection of hypoxic conditions in blood by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0010850 ! chemoreceptor signaling pathway involved in regulation of blood pressure is_a: GO:0070887 ! cellular response to chemical stimulus relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002008 name: excitation of vasomotor center by chemoreceptor signaling namespace: biological_process def: "The process by which the molecular signal from the carotid and aortic bodies is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by chemoreceptor signalling" EXACT [] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling relationship: part_of GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002009 name: morphogenesis of an epithelium namespace: biological_process def: "The process by which the anatomical structures of epithelia are generated and organized. Morphogenesis pertains to the creation of form. An epithelium consists of closely packed cells arranged in one or more layers, that covers the outer surfaces of the body or lines any internal cavity or tube." [GOC:dph, GOC:jl, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0060429 ! epithelium development [Term] id: GO:0002010 name: excitation of vasomotor center by baroreceptor signaling namespace: biological_process def: "The process by which the molecular signal from the arterial baroreceptors is relayed to the vasomotor center causing it to signal increase arterial pressure." [GOC:dph] synonym: "excitation of vasomotor center by baroreceptor signalling" EXACT [] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0002011 name: morphogenesis of an epithelial sheet namespace: biological_process def: "The process by which the anatomical structures of an epithelial sheet are generated and organized. Morphogenesis pertains to the creation of form. An epithelial sheet is a flat surface consisting of closely packed epithelial cells." [GOC:jl] is_a: GO:0002009 ! morphogenesis of an epithelium [Term] id: GO:0002012 name: vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:dph, GOC:mtg_cardio] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0002013 name: detection of carbon dioxide by vasomotor center namespace: biological_process def: "The process by a carbon dioxide stimulus is received and converted to a molecular signal by the vasomotor center of the central nervous system." [ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002014 name: vasoconstriction of artery involved in ischemic response to lowering of systemic arterial blood pressure namespace: biological_process def: "The vasoconstriction that is triggered by vasomotor excitation resulting from the detection of high carbon dioxide levels in the vasomotor center of the central nervous system." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure is_a: GO:0042310 ! vasoconstriction relationship: part_of GO:0001980 ! regulation of systemic arterial blood pressure by ischemic conditions [Term] id: GO:0002015 name: regulation of systemic arterial blood pressure by atrial baroreceptor feedback namespace: biological_process def: "A process that controls blood pressure by sensing the amount of stretch occurring in the atria." [GOC:dph, GOC:tb] synonym: "atrial baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "atrial control of blood pressure" RELATED [] synonym: "atrial low pressure baroreceptor regulation of blood pressure" EXACT [GOC:mtg_cardio] synonym: "atrial reflex" RELATED [GOC:dph] is_a: GO:0003015 ! heart process relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0002016 name: regulation of blood volume by renin-angiotensin namespace: biological_process def: "The process by which the renin-angiotensin system controls the rate of fluid intake and output into the blood." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin-angiotensin control of body fluid levels" RELATED [] synonym: "renin-angiotensin regulation of blood volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0002017 name: regulation of blood volume by renal aldosterone namespace: biological_process def: "The process by which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume." [GOC:dph, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "aldosterone mediated control of body fluids" RELATED [] synonym: "aldosterone mediated regulation of blood volume" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of blood volume by aldosterone" EXACT [GOC:dph, GOC:tb] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0002018 name: renin-angiotensin regulation of aldosterone production namespace: biological_process def: "The process by which an increase in active angiotensin stimulates the adrenal cortices to secrete aldosterone." [ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "renin-angiotensin control of aldosterone production" RELATED [] is_a: GO:0003014 ! renal system process relationship: part_of GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002019 name: regulation of renal output by angiotensin namespace: biological_process def: "The process by which angiotensin directly modulates the rate of urine output by the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "angiotensin mediated control of renal output" RELATED [] synonym: "angiotensin mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002020 name: protease binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protease or peptidase." [GOC:hjd] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0002021 name: response to dietary excess namespace: biological_process def: "The physiological process by which dietary excess is sensed by the central nervous system and results in a reduction in food intake and increased energy expenditure." [PMID:12161655] is_a: GO:0032501 ! multicellular organismal process is_a: GO:0050896 ! response to stimulus relationship: part_of GO:0040014 ! regulation of multicellular organism growth [Term] id: GO:0002022 name: detection of dietary excess namespace: biological_process def: "The mechanism by which the brain senses excessive caloric intake." [PMID:12161655] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002023 name: reduction of food intake in response to dietary excess namespace: biological_process def: "The specific actions of an organism that are triggered by the detection of dietary excess and result in a decreased intake of food." [PMID:12161655] is_a: GO:0042755 ! eating behavior relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002024 name: diet induced thermogenesis namespace: biological_process def: "The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signalling in the sympathetic nervous system." [PMID:12161655] is_a: GO:0044253 ! positive regulation of multicellular organismal metabolic process relationship: part_of GO:0002021 ! response to dietary excess [Term] id: GO:0002025 name: vasodilation by norepinephrine-epinephrine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change." [GOC:mtg_cardio, PMID:10358008] synonym: "noradrenaline-adrenaline vasodilation involved in regulation of blood pressure" EXACT [] synonym: "norepinephrine-epinephrine vasodilation during blood pressure regulation" EXACT [] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0002026 name: regulation of the force of heart contraction namespace: biological_process def: "Any process that modulates the extent of heart contraction, changing the force with which blood is propelled." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac inotropy" EXACT [GOC:dph, GOC:tb] synonym: "heart inotropy" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002027 name: regulation of heart rate namespace: biological_process def: "Any process that modulates the frequency or rate of heart contraction." [GOC:dph, GOC:tb, PMID:10358008] synonym: "cardiac chronotropy" EXACT [GOC:dph, GOC:tb] synonym: "regulation of heart contraction rate" EXACT [] synonym: "regulation of rate of heart contraction" EXACT [] is_a: GO:0008016 ! regulation of heart contraction is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0002028 name: regulation of sodium ion transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:dph] synonym: "regulation of Na+ transport" EXACT [] synonym: "regulation of sodium transport" EXACT [] is_a: GO:0010959 ! regulation of metal ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006814 ! sodium ion transport relationship: regulates GO:0006814 ! sodium ion transport [Term] id: GO:0002029 name: desensitization of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The process that stops, prevents or reduces the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity after prolonged stimulation with an agonist of the pathway." [PMID:8396717] synonym: "desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] is_a: GO:0022401 ! negative adaptation of signaling pathway is_a: GO:0045744 ! negative regulation of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002030 name: inhibitory G-protein coupled receptor phosphorylation namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by addition of a phosphate group to its third intracellular loop consensus site." [PMID:8396717] is_a: GO:0006468 ! protein amino acid phosphorylation relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002031 name: G-protein coupled receptor internalization namespace: biological_process def: "The process by which a G-protein coupled receptor is taken up into an endocytic vesicle." [PMID:8396717] is_a: GO:0031623 ! receptor internalization relationship: part_of GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway [Term] id: GO:0002032 name: desensitization of G-protein coupled receptor protein signaling pathway by arrestin namespace: biological_process def: "The process that inhibits the signaling function of a G-protein coupled receptor by uncoupling the receptor from its downstream G proteins." [GOC:dph, GOC:tb, PMID:8396717] synonym: "arrestin mediated desensitisation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "arrestin mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [GOC:dph, GOC:tb] synonym: "arrestin-mediated desensitization of G-protein coupled receptor protein signaling pathway" EXACT [] is_a: GO:0002029 ! desensitization of G-protein coupled receptor protein signaling pathway is_a: GO:0032091 ! negative regulation of protein binding [Term] id: GO:0002033 name: vasodilation by angiotensin involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the size of a blood vessel via the renin-angiotensin system." [ISBN:0323031951 "Principles of Physiology", PMID:10425188] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002034 ! regulation of blood vessel size by renin-angiotensin [Term] id: GO:0002034 name: regulation of blood vessel size by renin-angiotensin namespace: biological_process def: "The process where the diameter of a blood vessel is changed due to activity of the renin-angiotensin system." [GOC:dph, GOC:tb] synonym: "renin-angiotensin regulation of blood vessel size" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin is_a: GO:0050880 ! regulation of blood vessel size [Term] id: GO:0002035 name: brain renin-angiotensin system namespace: biological_process def: "The process by which an angiotensin-mediated signaling system present in the brain regulates the force with which blood passes through the circulatory system." [PMID:2909574] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0002016 ! regulation of blood volume by renin-angiotensin [Term] id: GO:0002036 name: regulation of L-glutamate transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of L-glutamate transport." [GOC:hjd] is_a: GO:0044070 ! regulation of anion transport is_a: GO:0051955 ! regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015813 ! L-glutamate transport relationship: regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002037 name: negative regulation of L-glutamate transport namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "down regulation of L-glutamate transport" EXACT [] synonym: "down-regulation of L-glutamate transport" EXACT [] synonym: "downregulation of L-glutamate transport" EXACT [] synonym: "inhibition of L-glutamate transport" NARROW [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0043271 ! negative regulation of ion transport is_a: GO:0051956 ! negative regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0015813 ! L-glutamate transport relationship: negatively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002038 name: positive regulation of L-glutamate transport namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of L-glutamate transport." [GOC:hjd] synonym: "activation of L-glutamate transport" NARROW [] synonym: "stimulation of L-glutamate transport" NARROW [] synonym: "up regulation of L-glutamate transport" EXACT [] synonym: "up-regulation of L-glutamate transport" EXACT [] synonym: "upregulation of L-glutamate transport" EXACT [] is_a: GO:0002036 ! regulation of L-glutamate transport is_a: GO:0043270 ! positive regulation of ion transport is_a: GO:0051957 ! positive regulation of amino acid transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0015813 ! L-glutamate transport relationship: positively_regulates GO:0015813 ! L-glutamate transport [Term] id: GO:0002039 name: p53 binding namespace: molecular_function def: "Interacting selectively and non-covalently with one of the p53 family of proteins." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002040 name: sprouting angiogenesis namespace: biological_process def: "The extension of new blood vessels from existing capillaries into avascular tissues resulting from the proliferation of blood vessel endothelial cells." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002041 name: intussusceptive angiogenesis namespace: biological_process def: "The formation of new blood vessels as a result of the insertion and extension of lumenal tissue pillars." [PMID:16391003] is_a: GO:0001525 ! angiogenesis [Term] id: GO:0002042 name: cell migration involved in sprouting angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels involved in sprouting angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002043 name: blood vessel endothelial cell proliferation involved in sprouting angiogenesis namespace: biological_process def: "The multiplication or reproduction of blood vessel endothelial cells, resulting in the expansion of a cell population contributing to sprouting angiogenesis." [GOC:dph, GOC:tb, PMID:16391003] synonym: "blood vessel endothelial cell proliferation during sprouting angiogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0001935 ! endothelial cell proliferation relationship: part_of GO:0002040 ! sprouting angiogenesis [Term] id: GO:0002044 name: blood vessel endothelial cell migration involved in intussusceptive angiogenesis namespace: biological_process def: "The orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels during intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0043534 ! blood vessel endothelial cell migration relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002045 name: regulation of cell adhesion involved in intussusceptive angiogenesis namespace: biological_process def: "The process that modulates the frequency, rate or extent of attachment of a blood vessel endothelial cell to another cell or to the extracellular matrix involved in intussusceptive angiogenesis." [PMID:16391003] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0002041 ! intussusceptive angiogenesis [Term] id: GO:0002046 name: opsin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an opsin, any of a group of hydrophobic, integral membrane glycoproteins located primarily in the disc membrane of rods or cones, involved in photoreception." [GOC:hjd] is_a: GO:0005515 ! protein binding [Term] id: GO:0002047 name: phenazine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a phenazine antibiotic, a polycyclic pyrazine with two nitrogen atoms in the ring." [GOC:dph] subset: gosubset_prok synonym: "acridizine biosynthesis" RELATED [] synonym: "acridizine biosynthetic process" RELATED [] synonym: "azophenylene biosynthesis" RELATED [] synonym: "azophenylene biosynthetic process" RELATED [] synonym: "dibenzo-p-diazine biosynthesis" RELATED [] synonym: "dibenzo-p-diazine biosynthetic process" RELATED [] synonym: "dibenzopyrazine biosynthesis" RELATED [] synonym: "dibenzopyrazine biosynthetic process" RELATED [] is_a: GO:0017000 ! antibiotic biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0002048 name: pyoverdine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the siderochrome pyoverdine." [PMID:15317763] synonym: "pyoverdine metabolism" EXACT [] is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0002049 name: pyoverdine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0019290 ! siderophore biosynthetic process [Term] id: GO:0002050 name: pyoverdine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the siderochrome pyoverdine." [PMID:15317763] is_a: GO:0002048 ! pyoverdine metabolic process is_a: GO:0046215 ! siderophore catabolic process [Term] id: GO:0002051 name: osteoblast fate commitment namespace: biological_process def: "The commitment of mesenchymal cells to the specific cell fate of an osteoblast. An osteoblast is a bone-forming cell which secretes an extracellular matrix. Hydroxyapatite crystals are then deposited into the matrix to form bone." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002052 name: positive regulation of neuroblast proliferation namespace: biological_process def: "Any process that activates or increases the rate of neuroblast proliferation." [GOC:dph] synonym: "activation of neuroblast proliferation" NARROW [] synonym: "stimulation of neuroblast proliferation" NARROW [] synonym: "up regulation of neuroblast proliferation" EXACT [] synonym: "up-regulation of neuroblast proliferation" EXACT [] synonym: "upregulation of neuroblast proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0050769 ! positive regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007405 ! neuroblast proliferation relationship: positively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0002053 name: positive regulation of mesenchymal cell proliferation namespace: biological_process def: "The process of activating or increasing the rate or extent of mesenchymal cell proliferation. Mesenchymal cells are loosely organized embryonic cells." [GOC:dph] synonym: "activation of mesenchymal cell proliferation" NARROW [] synonym: "stimulation of mesenchymal cell proliferation" NARROW [] synonym: "up regulation of mesenchymal cell proliferation" EXACT [] synonym: "up-regulation of mesenchymal cell proliferation" EXACT [] synonym: "upregulation of mesenchymal cell proliferation" EXACT [] is_a: GO:0008284 ! positive regulation of cell proliferation is_a: GO:0010464 ! regulation of mesenchymal cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010463 ! mesenchymal cell proliferation relationship: positively_regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0002054 name: nucleobase binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nucleobase, any of a class of pyrmidines or purines, organic nitrogenous bases." [GOC:hjd] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0002055 name: adenine binding namespace: molecular_function def: "Interacting selectively and non-covalently with adenine, a purine base." [GOC:hjd] synonym: "6-aminopurine binding" EXACT [] is_a: GO:0002060 ! purine binding [Term] id: GO:0002056 name: cytosine binding namespace: molecular_function def: "Interactiing selectively with cytosine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine binding [Term] id: GO:0002057 name: guanine binding namespace: molecular_function def: "Interacting selectively and non-covalently with guanine." [GOC:hjd] is_a: GO:0002060 ! purine binding [Term] id: GO:0002058 name: uracil binding namespace: molecular_function def: "Interacting selectively and non-covalently with uracil." [GOC:hjd] is_a: GO:0002061 ! pyrimidine binding [Term] id: GO:0002059 name: thymine binding namespace: molecular_function def: "Interacting selectively and non-covalently with thymine." [GOC:hjd] is_a: GO:0002061 ! pyrimidine binding [Term] id: GO:0002060 name: purine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a purine, an organic nitrogenous base." [GOC:hjd] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002061 name: pyrimidine binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pyrimidine, an organic nitrogenous base." [GOC:hjd] synonym: "1,3-diazine binding" EXACT [] is_a: GO:0002054 ! nucleobase binding [Term] id: GO:0002062 name: chondrocyte differentiation namespace: biological_process def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0051216 ! cartilage development [Term] id: GO:0002063 name: chondrocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a chondrocyte over time, from its commitment to its mature state. Chondrocyte development does not include the steps involved in committing a chondroblast to a chondrocyte fate." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0002062 ! chondrocyte differentiation [Term] id: GO:0002064 name: epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of an epithelial cell over time, from its formation to the mature structure. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002065 name: columnar/cuboidal epithelial cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of a columnar/cuboidal epithelial cell. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0030855 ! epithelial cell differentiation [Term] id: GO:0002066 name: columnar/cuboidal epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a columnar/cuboidal epithelial cell over time, from its formation to the mature structure. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002064 ! epithelial cell development relationship: part_of GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002067 name: glandular epithelial cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of a glandular epithelial cell. A glandular epithelial cell is a columnar/cuboidal epithelial cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002065 ! columnar/cuboidal epithelial cell differentiation [Term] id: GO:0002068 name: glandular epithelial cell development namespace: biological_process def: "The process whose specific outcome is the progression of a glandular epithelial cell over time, from its formation to the mature structure. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002066 ! columnar/cuboidal epithelial cell development relationship: part_of GO:0002067 ! glandular epithelial cell differentiation [Term] id: GO:0002069 name: columnar/cuboidal epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a columna/cuboidal epithelial cell to attain its fully functional state. A columnar/cuboidal epithelial cell is a cell usually found in a two dimensional sheet with a free surface. Columnar/cuboidal epithelial cells take on the shape of a column or cube." [GOC:dph] is_a: GO:0002070 ! epithelial cell maturation relationship: part_of GO:0002066 ! columnar/cuboidal epithelial cell development [Term] id: GO:0002070 name: epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for an epithelial cell to attain its fully functional state. An epithelial cell is a cell usually found in a two-dimensional sheet with a free surface." [GOC:dph] is_a: GO:0048469 ! cell maturation relationship: part_of GO:0002064 ! epithelial cell development [Term] id: GO:0002071 name: glandular epithelial cell maturation namespace: biological_process def: "The developmental process, independent of morphogenetic (shape) change, that is required for a glandular epithelial cell to attain its fully functional state. A glandular epithelial cell is a columnar/cuboidal epithelial cell is a cell found in a two dimensional sheet with a free surface exposed to the lumen of a gland." [GOC:dph] is_a: GO:0002069 ! columnar/cuboidal epithelial cell maturation relationship: part_of GO:0002068 ! glandular epithelial cell development [Term] id: GO:0002072 name: optic cup morphogenesis involved in camera-type eye development namespace: biological_process def: "The invagination of the optic vesicle to form two-walled indentations, the optic cups, that will go on to form the retina. This process begins with the optic vesicle becoming a two-walled structure and its subsequent shape changes. It does not include the fate commitment of cells to become the pigmented retina and the neural retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb, ISBN:0878932437] synonym: "optic cup morphogenesis involved in camera-style eye development" EXACT [] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0060900 ! embryonic camera-type eye formation [Term] id: GO:0002074 name: extraocular skeletal muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the extraocular skeletal muscle over time, from its formation to the mature structure. The extraocular muscle is derived from cranial mesoderm and controls eye movements. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_muscle, GOC:mtg_sensu, MA:0001271, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002075 name: somitomeric trunk muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somitomeric trunk muscle over time, from its formation to the mature structure. The somitomeric trunk muscle is derived from somitomeric mesoderm. The muscle begins its development with the differentiation of the muscle cells and ends with the mature muscle. An example of this process is found in Mus musculus." [GOC:dph, PMID:16638982] is_a: GO:0007519 ! skeletal muscle tissue development [Term] id: GO:0002076 name: osteoblast development namespace: biological_process def: "The process whose specific outcome is the progression of an osteoblast over time, from its formation to the mature structure. Osteoblast development does not include the steps involved in committing a cranial neural crest cell or an osteoprogenitor cell to an osteoblast fate. An osteoblast is a cell that gives rise to bone." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0001649 ! osteoblast differentiation [Term] id: GO:0002077 name: acrosome matrix dispersal namespace: biological_process def: "The proteolytic digestion of components in the acrosomal matrix that allows for their release into the egg. The dispersal of the components allows for the inner acrosomal membrane to interact with the egg." [GOC:dph, PMID:3886029] is_a: GO:0048610 ! reproductive cellular process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002078 name: membrane fusion involved in acrosome reaction namespace: biological_process def: "The fusion of the plasma membrane of the sperm with the outer acrosomal membrane." [GOC:dph, PMID:3886029] synonym: "membrane fusion involved in the acrosomal reaction" EXACT [] is_a: GO:0006944 ! cellular membrane fusion relationship: part_of GO:0007340 ! acrosome reaction [Term] id: GO:0002079 name: inner acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the acrosomal vesicle and is located toward the sperm nucleus. This region is responsible for molecular interactions allowing the sperm to penetrate the zona pellucida and fuses with the egg plasma membrane." [GOC:dph, PMID:3899643, PMID:8936405] comment: Note that this term is not a descendant of 'organelle inner membrane ; GO:0019866' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002080 name: acrosomal membrane namespace: cellular_component def: "The membrane that surrounds the acrosomal lumen. The acrosome is a special type of lysosome in the head of a spermatozoon that contains acid hydrolases and is concerned with the breakdown of the outer membrane of the ovum during fertilization." [GOC:dph] is_a: GO:0030667 ! secretory granule membrane relationship: part_of GO:0001669 ! acrosomal vesicle [Term] id: GO:0002081 name: outer acrosomal membrane namespace: cellular_component def: "The acrosomal membrane region that underlies the plasma membrane of the sperm. This membrane fuses with the sperm plasma membrane as part of the acrosome reaction." [GOC:dph, PMID:8936405] comment: Note that this term is not a descendant of 'organelle outer membrane ; GO:0031968' because the outer acrosomal membrane is a portion of the acrosomal membrane; the latter is a single lipid bilayer. is_a: GO:0044425 ! membrane part is_a: GO:0044433 ! cytoplasmic vesicle part relationship: part_of GO:0002080 ! acrosomal membrane [Term] id: GO:0002082 name: regulation of oxidative phosphorylation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [GOC:dph] is_a: GO:0042325 ! regulation of phosphorylation is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006119 ! oxidative phosphorylation relationship: regulates GO:0006119 ! oxidative phosphorylation [Term] id: GO:0002083 name: 4-hydroxybenzoate decaprenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: decaprenyl-PP + p-hydroxybenzoate = decaprenyl-4-hydroxybenzoate + diphosphate." [GOC:hjd] is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0002084 name: protein depalmitoylation namespace: biological_process def: "The removal of palymitoyl groups from a lipoprotein." [GOC:hjd] is_a: GO:0006464 ! protein modification process is_a: GO:0042159 ! lipoprotein catabolic process [Term] id: GO:0002085 name: inhibition of neuroepithelial cell differentiation namespace: biological_process def: "Any process that prevents the activation of neuroepithelial cell differentiation. Neuroepithelial cell differentiation is the process by which epiblast cells acquire specialized features of neuroepithelial cells." [GOC:dph, PMID:16678814] synonym: "negative regulation of neural plate formation" NARROW [GOC:dph, GOC:tb] synonym: "repression of premature neural plate formation" NARROW [GOC:dph, GOC:tairtb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045596 ! negative regulation of cell differentiation is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0048505 ! regulation of timing of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation relationship: negatively_regulates GO:0060563 ! neuroepithelial cell differentiation [Term] id: GO:0002086 name: diaphragm contraction namespace: biological_process def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. This process occurs in the diaphragm. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The diaphragm is a striated muscle that is necessary for the process of respiratory gaseous exchange." [GOC:dph, GOC:mtg_muscle, PMID:12458206] is_a: GO:0003011 ! involuntary skeletal muscle contraction is_a: GO:0003016 ! respiratory system process [Term] id: GO:0002087 name: regulation of respiratory gaseous exchange by neurological system process namespace: biological_process def: "A process carried out by the nervous system that is required for the proper control of respiratory gaseous exchange. This process occurs in the respiratory center of the brain in vertebrates." [GOC:dph, GOC:tb, PMID:12458206] synonym: "neurological control of breathing" EXACT [GOC:dph, GOC:tb] is_a: GO:0044065 ! regulation of respiratory system process is_a: GO:0050877 ! neurological system process [Term] id: GO:0002088 name: lens development in camera-type eye namespace: biological_process def: "The process whose specific outcome is the progression of the lens over time, from its formation to the mature structure. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, ISBN:0582064333] synonym: "lens development" EXACT [] synonym: "lens development in camera-style eye" EXACT [] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development [Term] id: GO:0002089 name: lens morphogenesis in camera-type eye namespace: biological_process def: "The process by which the anatomical structures of the lens are generated and organized. Morphogenesis pertains to the creation of form. The lens is a transparent structure in the eye through which light is focused onto the retina. An example of this process is found in Mus musculus." [GOC:dph, GOC:mtg_sensu] synonym: "lens morphogenesis" EXACT [] synonym: "lens morphogenesis in camera-style eye" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0002088 ! lens development in camera-type eye relationship: part_of GO:0048593 ! camera-type eye morphogenesis [Term] id: GO:0002090 name: regulation of receptor internalization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor internalization." [GOC:hjd] is_a: GO:0031323 ! regulation of cellular metabolic process is_a: GO:0048259 ! regulation of receptor-mediated endocytosis is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0031623 ! receptor internalization relationship: regulates GO:0031623 ! receptor internalization [Term] id: GO:0002091 name: negative regulation of receptor internalization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "down regulation of receptor internalization" EXACT [] synonym: "down-regulation of receptor internalization" EXACT [] synonym: "downregulation of receptor internalization" EXACT [] synonym: "inhibition of receptor internalization" NARROW [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010605 ! negative regulation of macromolecule metabolic process is_a: GO:0031324 ! negative regulation of cellular metabolic process is_a: GO:0048261 ! negative regulation of receptor-mediated endocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0031623 ! receptor internalization relationship: negatively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002092 name: positive regulation of receptor internalization namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of receptor internalization." [GOC:hjd] synonym: "activation of receptor internalization" NARROW [] synonym: "stimulation of receptor internalization" NARROW [] synonym: "up regulation of receptor internalization" EXACT [] synonym: "up-regulation of receptor internalization" EXACT [] synonym: "upregulation of receptor internalization" EXACT [] is_a: GO:0002090 ! regulation of receptor internalization is_a: GO:0010604 ! positive regulation of macromolecule metabolic process is_a: GO:0031325 ! positive regulation of cellular metabolic process is_a: GO:0048260 ! positive regulation of receptor-mediated endocytosis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0031623 ! receptor internalization relationship: positively_regulates GO:0031623 ! receptor internalization [Term] id: GO:0002093 name: auditory receptor cell morphogenesis namespace: biological_process def: "Any process that alters the size or shape of an auditory receptor cell." [GOC:dph, GOC:tb] synonym: "hair cell morphogenesis" BROAD [GO:dph] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042472 ! inner ear morphogenesis relationship: part_of GO:0060117 ! auditory receptor cell development [Term] id: GO:0002094 name: polyprenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of multiple prenyl groups from one compound (donor) to another (acceptor)." [GOC:hjd] subset: gosubset_prok is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0002095 name: caveolar macromolecular signaling complex namespace: cellular_component def: "A complex composed of proteins required for beta adrenergic receptor activation of protein kinase A. It includes the Cav 12. subunit of L-type calcium channel, protein kinase A regulatory subunit 2(PKAR2), adenyl cyclase, beta-adrenergic receptor, G-alpha-S, protein phosphatase 2A (PP2A) and caveolin 3 (CAV3)." [PMID:16648270] synonym: "caveolar macromolecular signalling complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005901 ! caveola [Term] id: GO:0002096 name: polkadots namespace: cellular_component def: "A punctate, filamentous structure composed of Bcl10 that appears in the cytoplasm of T-cells shortly after T-cell receptor stimulation. Polkadots stands for Punctate Oligomeric Killing and Activating DOmains Transducing Signals." [PMID:14724296, PMID:16495340] comment: Note that polkadots also contains some amount of MALT1. Interaction with MALT1 is required for formation of the polkadots. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0002097 name: tRNA wobble base modification namespace: biological_process def: "The process whereby the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0006400 ! tRNA modification [Term] id: GO:0002098 name: tRNA wobble uridine modification namespace: biological_process def: "The process whereby a uridine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002099 name: tRNA wobble guanine modification namespace: biological_process def: "The process whereby a guanine in t position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002100 name: tRNA wobble adenosine to inosine editing namespace: biological_process def: "The process whereby an adenosine in position 34 of a tRNA is post-transcriptionally corverted to inosine." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002101 name: tRNA wobble cytosine modification namespace: biological_process def: "The process whereby a cytosine in position 34 of a tRNA is post-transcriptionally modified." [GOC:hjd, ISBN:155581073X] is_a: GO:0002097 ! tRNA wobble base modification [Term] id: GO:0002102 name: podosome namespace: cellular_component def: "An actin-rich adhesion structure characterized by formation upon cell substrate contact and localization at the substrate-attached part of the cell, contain an F-actin-rich core surrounded by a ring structure containing proteins such as vinculin and talin, and have a diameter of 0.5 mm." [PMID:12837608, PMID:15890982] comment: Note that podosomes can be distinguished from other F-actin-rich structures or from other matrix contacts. For example, focal adhesions and focal contacts do not display a core structure of F-actin. Unlike focal adhesions, podosome assembly does not require de novo protein synthesis. However, most of the podosome ring components are found in focal adhesions and other cell-matrix contacts. Podosomes are typically found in cells that cross tissue boundaries, recruited to the leading edge of migrating cells, and are often sites of extracellular matrix degradation. xref: Wikipedia:Podosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0002103 name: endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage of a pre-rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Primary ribosomal RNA transcripts with four genes, in this order, are produced in the chloroplasts of vascular plants. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0000478 ! endonucleolytic cleavage involved in rRNA processing [Term] id: GO:0002104 name: endonucleolytic cleaveage between 4.5S rRNA and 5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the 5S rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002105 name: endonucleolytic cleaveage between LSU-rRNA and 4.5S rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavage between the LSU-rRNA and the 4.5S rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002106 name: endonucleolytic cleaveage between SSU-rRNA and LSU-rRNA of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) namespace: biological_process def: "Endonucleolytic cleavages between the SSU-rRNA and the LSU-rRNA of an rRNA molecule originally produced as a tetracistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 4.5S rRNA, and the 5S rRNA in that order from 5' to 3' along the primary transcript. These cleavages liberate tRNAs from the polycistronic transcript as well as separating the SSU and LSU containing transcript. Note that the use of the word tetracistronic refers only to the number of mature rRNA molecules which will be produced from the primary transcript and ignores tRNAs that may also be present within the primary transcript." [GOC:curators] is_a: GO:0002103 ! endonucleolytic cleavage of tetracistronic rRNA transcript (SSU-rRNA, LSU-rRNA, 4.5S-rRNA, 5S-rRNA) [Term] id: GO:0002107 name: generation of mature 3'-end of 5S rRNA generated by RNA polymerase III namespace: biological_process def: "The removal of extra uridine residues from the 3' end of a 5S pre-rRNA generated by transcription by RNA polymerase III to generate the mature 3'-end." [GOC:hjd, PMID:16387655, PMID:1748637, PMID:1902221, PMID:8389357] is_a: GO:0000481 ! maturation of 5S rRNA is_a: GO:0031125 ! rRNA 3'-end processing [Term] id: GO:0002108 name: maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Large SubUnit (LSU) ribosomal RNA (rRNA) molecule into a mature LSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0000470 ! maturation of LSU-rRNA [Term] id: GO:0002109 name: maturation of SSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, LSU-rRNA,5S) namespace: biological_process def: "Any process involved in the maturation of a precursor Small SubUnit (SSU) ribosomal RNA (rRNA) molecule into a mature SSU-rRNA molecule from the pre-rRNA molecule originally produced as a tricistronic rRNA transcript that contains the Small Subunit (SSU) rRNA, Large Subunit (LSU) the 5S rRNA in that order from 5' to 3' along the primary transcript." [GOC:curators] is_a: GO:0030490 ! maturation of SSU-rRNA [Term] id: GO:0002110 name: cotranscriptional mitochondrial rRNA nucleotide insertion namespace: biological_process def: "The insertion of one or two non-coded nucleotides during the transcription of a mitochondrial rRNA. Such additions are known to occur in myxomycetes such as Physarum, Didymium, and Stemonitis." [GOC:curators, ISBN:1555811337 "Modification and Editing of RNA", PMID:8306965] is_a: GO:0000154 ! rRNA modification is_a: GO:0070705 ! RNA nucleotide insertion [Term] id: GO:0002111 name: BRCA2-BRAF35 complex namespace: cellular_component def: "A heterodimeric complex of BRCA2 and BRAF35 (BRCA2-associated factor 35). The BRCA2-BRAF35 complex is often associated with condensed chromatin during mitosis." [GOC:hjd, PMID:11207365] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0002112 name: interleukin-33 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-33 receptor." [GOC:hjd] synonym: "IL-33" NARROW [GOC:mah] synonym: "interleukin-33 receptor ligand" NARROW [GOC:mah] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0002113 name: interleukin-33 binding namespace: molecular_function def: "Interacting selectively and non-covalently with interleukin-33." [GOC:hjd] synonym: "IL-33 binding" EXACT [GOC:mah] is_a: GO:0019955 ! cytokine binding [Term] id: GO:0002114 name: interleukin-33 receptor activity namespace: molecular_function def: "Combining with interleukin-33 to initiate a change in cell activity." [GOC:hjd] synonym: "IL-33 receptor activity" EXACT [GOC:mah] synonym: "IL-33R" EXACT [GOC:mah] is_a: GO:0002113 ! interleukin-33 binding is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0002115 name: store-operated calcium entry namespace: biological_process def: "A calcium ion entry mechanism in the plasma membrane activated by the depletion of calcium ion from the internal calcium ion store in the endoplasmic reticulum." [GOC:hjd, PMID:11120592, PMID:17956991] comment: SOCE is initiated by response to stiumlation of membrane receptors leading to the hydrolysis ofphosphatidylinositol bisphosphate (PIP2), inositol 1,4,5-trisphosphate (IP3) generation, and IP3-mediated calcium ion release from the endoplasmic reticulum. synonym: "calcium ion import" BROAD [] synonym: "capacitative calcium entry" EXACT [] synonym: "SOCE" EXACT [] synonym: "store-operated calcium import" EXACT [] is_a: GO:0006816 ! calcium ion transport [Term] id: GO:0002116 name: semaphorin receptor complex namespace: cellular_component def: "A stable binary complex of a neurophilin and a plexin, together forming a functional semaphorin receptor." [GOC:hjd, PMID:10934324, PMID:12367632, PMID:12613544] synonym: "plexin-neurophilin complex" EXACT [] is_a: GO:0043235 ! receptor complex [Term] id: GO:0002117 name: amphibian larval development namespace: biological_process def: "The process whose specific outcome is the progression of the amphibian larva over time, from its formation to the mature structure. Amphibian larvae, sometimes called pollywogs or tadpoles, hatch from eggs and begin to grow limbs and other adult physical features at various times, depending on the species, before they metamorphose into the adult form." [GOC:bf, GOC:go_curators, http://www.livingunderworld.org/biology/] is_a: GO:0002164 ! larval development [Term] id: GO:0002118 name: aggressive behavior namespace: biological_process def: "A behavioral interaction between organisms in which one organism has the intention of inflicting physical damage on another individual." [GOC:hjd] synonym: "aggression" EXACT [] xref: Wikipedia:Aggression is_a: GO:0051705 ! behavioral interaction between organisms [Term] id: GO:0002119 name: nematode larval development namespace: biological_process def: "The process whose specific outcome is the progression of the nematode larva over time, from its formation to the mature structure. Nematode larval development begins with the newly hatched first-stage larva (L1) and ends with the end of the last larval stage (for example the fourth larval stage (L4) in C. elegans). Each stage of nematode larval development is characterized by proliferation of specific cell lineages and an increase in body size without alteration of the basic body plan. Nematode larval stages are separated by molts in which each stage-specific exoskeleton, or cuticle, is shed and replaced anew." [GOC:ems, GOC:kmv] is_a: GO:0002164 ! larval development [Term] id: GO:0002120 name: predatory aggressive behavior namespace: biological_process def: "Aggressive behavior involving attack on prey by a predator, characterized by lack of threatening displays, silence, and no sex differences." [GOC:hjd] synonym: "predatory aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002121 name: inter-male aggressive behavior namespace: biological_process def: "Aggressive behavior based on competition between males of the same species over access to resources such as females, dominance, status, etc. and characterized by noise, threats, and is often less injurious." [GOC:hjd] synonym: "inter-male aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002122 name: fear-induced aggressive behavior namespace: biological_process def: "Aggressive behavior associated with attempts to flee from a threat." [GOC:hjd] synonym: "fear-induced aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002123 name: irritable aggressive behavior namespace: biological_process def: "Aggressive behavior induced by frustration and directed against an available target." [GOC:hjd] synonym: "irritable aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002124 name: territorial aggressive behavior namespace: biological_process def: "Aggressive behavior performed in defence of a fixed area against intruders, typically conspecifics." [GOC:hjd] synonym: "territorial aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002125 name: maternal aggressive behavior namespace: biological_process def: "Aggressive behavior of a female to protect her offspring from a threat." [GOC:hjd] comment: Paternal aggression also exists. Serves to protect the offspring from intruders. synonym: "maternal aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002126 name: instrumental aggressive behavior namespace: biological_process def: "Aggressive behavior directed towards obtaining some goal, considered to be a learned response to a situation." [GOC:hjd] synonym: "instrumental aggression" EXACT [] is_a: GO:0002118 ! aggressive behavior [Term] id: GO:0002127 name: wobble base cytosine methylation namespace: biological_process def: "The process whereby the base of cytosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the C5 position." [GOC:hjd, ISBN:155581073X] synonym: "wobble position m5C biosynthesis" EXACT [] is_a: GO:0002101 ! tRNA wobble cytosine modification is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002128 name: tRNA nucleoside ribose methylation namespace: biological_process def: "The process by which the sugar of a nucleoside in tRNA is modified at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0030488 ! tRNA methylation [Term] id: GO:0002129 name: wobble position guanine ribose methylation namespace: biological_process def: "The process whereby the ribose of guanosine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002130 name: wobble position ribose methylation namespace: biological_process def: "The process whereby the ribose base of the nucleotide at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002128 ! tRNA nucleoside ribose methylation [Term] id: GO:0002131 name: wobble position cytosine ribose methylation namespace: biological_process def: "The process whereby the ribose of cytidine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002132 name: wobble position uridine ribose methylation namespace: biological_process def: "The process whereby the ribose of uridine at position 34 in the anticodon of a tRNA is post-transcriptionally methylated at the 2'-O position." [GOC:hjd, ISBN:155581073X] is_a: GO:0002130 ! wobble position ribose methylation [Term] id: GO:0002133 name: polycystin complex namespace: cellular_component def: "A stable heterodimeric complex composed of polycystin-1 and polycystin-2." [GOC:hjd, PMID:11901144] comment: Different forms of the complex differing in type of N-glycosylation of polycystin-1 can exist (endoglycosidase sensitive and endoglycosidase resistant). is_a: GO:0043234 ! protein complex [Term] id: GO:0002134 name: UTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with UTP, uridine 5'-triphosphate." [GOC:hjd, ISBN:0198506732 "Oxford Dictionary"] is_a: GO:0032557 ! pyrimidine ribonucleotide binding [Term] id: GO:0002135 name: CTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with CTP, cytidine 5'-triphosphate." [GOC:hjd, ISBN:0124020607 "The Anatomical Basis of Mouse Development"] is_a: GO:0032557 ! pyrimidine ribonucleotide binding [Term] id: GO:0002136 name: wobble base lysidine biosynthesis namespace: biological_process def: "The process whereby the carbonyl of cytosine at position 34 of a tRNA is post-transcriptionally replaced by lysine." [PMID:15894617] comment: Exclusively located at the anticodon wobble position (i.e., position 34) of eubacterial and some organellar tRNAIle2. This modification converts the codon specificity from AUG to AUA, and it also converts the aminoacylation specificity of the tRNA from methionine to isoleucine. Requires ATP. is_a: GO:0002101 ! tRNA wobble cytosine modification [Term] id: GO:0002137 name: nuclear cluster namespace: cellular_component def: "Discrete hetero-chromatin-containing foci in interphase nuclei, which comprise clusters of centromeric DNA (as defined by gamma-satellite sequences and the abundance of heterochromatin protein 1 (HP-1) ." [PMID:9413993] is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031618 ! nuclear centromeric heterochromatin created_by: hjd creation_date: 2009-04-22T12:51:32Z [Term] id: GO:0002138 name: retinoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the biosynthesis of retinoic acid, one of the three components that makes up vitamin A." [GOC:hjd] synonym: "retinoic acid anabolic process" EXACT [] is_a: GO:0042573 ! retinoic acid metabolic process is_a: GO:0044249 ! cellular biosynthetic process created_by: hjd creation_date: 2009-05-01T10:53:24Z [Term] id: GO:0002139 name: stereocilia coupling link namespace: cellular_component def: "A structure involved in coupling stereocilia to one another in sensory hair cells There are four morphologically distinct types: tip links, horizontal top connectors, shaft connectors and ankle links. Tip links and horizontal top connectors are the only inter-stereocilia links associated with mature cochlea, whereas ankle links appear during development of the auditory hair bundle." [PMID:16775142] is_a: GO:0044464 ! cell part created_by: hjd creation_date: 2009-05-06T10:25:38Z [Term] id: GO:0002140 name: stereocilia tip link namespace: cellular_component def: "A stereocilia link that is formed by a fine filament running more or less vertically upward from the tip of each shorter stereocilium to attach at a higher point on its adjacent taller neighbor. Tilting the bundle puts tension on the filaments, which pull on mechanically gated ion channels in the membrane of the stereocilia." [PMID:1108787] is_a: GO:0002139 ! stereocilia coupling link created_by: hjd creation_date: 2009-05-06T10:28:10Z [Term] id: GO:0002141 name: stereocilia ankle link namespace: cellular_component def: "A stereocilia coupling link that is composed of a fine filament present in developing stereocilia that couples the bases of individual stereocilia to one another. They are not present in mature stereocilia." [PMID:17567809] is_a: GO:0002139 ! stereocilia coupling link created_by: hjd creation_date: 2009-05-06T10:31:56Z [Term] id: GO:0002142 name: stereocilia ankle link complex namespace: cellular_component def: "A complex of proteins that connect growing stereocilia in developing cochlear hair cells, composed of Vlgr1, usherin, vezatin, and whirlin." [PMID:16775142] is_a: GO:0043234 ! protein complex relationship: part_of GO:0002141 ! stereocilia ankle link created_by: hjd creation_date: 2009-05-06T10:33:57Z [Term] id: GO:0002143 name: wobble position uridine thiolation namespace: biological_process def: "The process whereby a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps." [PMID:16871210] comment: In E. coli, the first step of the reaction is reductive elimination of sulfur from L-cysteine by IscS cysteine desulfurase to form an enzyme-bound cysteine-persulfide intermediate. Then, five essential gene products, TusA, TusB, TusC, TusD and TusE, mediate a sulfur relay that delivers the terminal sulfur of persulfide from IscS to MnmA12. The last protein, MnmA catalyzes the transfer of the sulfur from IscS to an ATP activated U34 of the tRNA. synonym: "tRNA wobble uridine thiolation" EXACT [GOC:mah] synonym: "wobble position s2U biosynthesis" EXACT [] is_a: GO:0002098 ! tRNA wobble uridine modification is_a: GO:0034227 ! tRNA thio-modification created_by: hjd creation_date: 2009-05-06T05:05:40Z [Term] id: GO:0002144 name: cytosolic tRNA wobble base thiouridylase complex namespace: cellular_component def: "A complex of two proteins involved in the thiolation of U34 in glutamate, lysine, and glutamine tRNAs of eukaryotes." [PMID:18391219] synonym: "Cut1-Cut2 complex" NARROW [] synonym: "tRNA thiouridylase" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part created_by: hjd creation_date: 2009-05-08T02:32:55Z [Term] id: GO:0002145 name: 4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphatase activity namespace: molecular_function def: "4-amino-5-hydroxymethyl-2-methylpyrimidine diphosphate + water = 2-methyl-4-amino-5-hydroxymethyl pyrimidine monophosphate + phosphate." [GOC:hjd] synonym: "HMP-PP diphosphatase" EXACT [] synonym: "HMP-PP pyrophosphatase" EXACT [] is_a: GO:0016462 ! pyrophosphatase activity created_by: hjd creation_date: 2009-06-10T11:21:35Z [Term] id: GO:0002146 name: steroid hormone receptor nuclear translocation namespace: biological_process def: "The directed movement of a steroid hormone receptor into the nucleus." [GOC:hjd] is_a: GO:0000060 ! protein import into nucleus, translocation created_by: hjd creation_date: 2009-07-09T02:34:42Z [Term] id: GO:0002147 name: glucocorticoid receptor nuclear translocation namespace: biological_process def: "The directed movement of a glucocorticoid receptor into the nucleus." [GOC:hjd] is_a: GO:0002146 ! steroid hormone receptor nuclear translocation relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway created_by: hjd creation_date: 2009-07-09T02:36:09Z [Term] id: GO:0002148 name: hypochlorous acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hypochlorous acid." [GOC:add, PMID:176150, PMIG:10085024] synonym: "HClO metabolic process" EXACT [] synonym: "HOCl metabolic process" EXACT [] synonym: "hypochlorite metabolic process" RELATED [] synonym: "hypochlorous acid metabolism" EXACT [] is_a: GO:0070276 ! halogen metabolic process created_by: hjd creation_date: 2009-10-13T10:27:48Z [Term] id: GO:0002149 name: hypochlorous acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hypochlorous acid." [GOC:add, PMID:10085024, PMID:176150] comment: Note that this reaction is catalyzed by myeloperoxidase in neutrophils. synonym: "HClO biosynthetic process" EXACT [] synonym: "HOCl biosynthetic process" EXACT [] synonym: "hypochlorite biosynthetic process" RELATED [] synonym: "hypochlorous acid biosynthesis" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process created_by: hjd creation_date: 2009-10-13T10:32:35Z [Term] id: GO:0002150 name: hypochlorous acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypochlorous acid." [GOC:add] synonym: "HClO catabolic process" EXACT [] synonym: "HOCl catabolic process" EXACT [] synonym: "hypochlorite catabolic process" RELATED [] synonym: "hypochlorous acid catabolism" EXACT [] is_a: GO:0002148 ! hypochlorous acid metabolic process created_by: hjd creation_date: 2009-10-13T10:36:09Z [Term] id: GO:0002151 name: G-quadruplex RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with G-quadruplex RNA structures, in which groups of four guanines adopt a flat, cyclic hydrogen-bonding arrangement known as a guanine tetrad." [PMID:18294969, PMID:18568163, PMID:19330720] comment: The structures of RNA and DNA G quartets differ regarding sugar conformation so that a protein binding to the RNA structure might not bind to the DNA structure. synonym: "G quadruplex binding" EXACT [GOC:mah] synonym: "G quartet binding" BROAD [GOC:hjd] synonym: "G quartet RNA binding" EXACT [GOC:hjd] synonym: "G-quartet binding" BROAD [GOC:mah] is_a: GO:0003723 ! RNA binding created_by: hjd creation_date: 2009-10-22T01:38:02Z [Term] id: GO:0002152 name: bile acid conjugation namespace: biological_process def: "The process whereby bile acids are covalently linked to taurine or glycine." [PMID:1094911, PMID:708413] comment: The bile acid is first activated using CoA by cholate-CoA ligase activity(GO:0047747), then conjugated to taurine or glycine by glycine N-choloyltransferase activity (GO:0047963; appears to use either glycine or taurine). is_a: GO:0008206 ! bile acid metabolic process created_by: hjd creation_date: 2009-10-29T01:41:51Z [Term] id: GO:0002153 name: steroid receptor RNA activator RNA binding namespace: molecular_function def: "Selectively interacting with the steroid receptor RNA activator RNA (SRA). SRA enhances steroid hormone receptor transcriptional activity as an RNA transcript by an indirect mechanism that does not involve SRA-steroid receptor binding." [PMID:10199399, PMID:15180993] comment: Note: there is also evidence that the RNA itself may code a protein (solution structure of mouse steroid receptor RNA activator 1 (SRA1) protein submitted to PDB by Riken). synonym: "SRA binding" EXACT [] is_a: GO:0003727 ! single-stranded RNA binding created_by: hjd creation_date: 2009-11-16T02:18:55Z [Term] id: GO:0002154 name: thyroid hormone mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a thyroid hormone." [GOC:hjd] is_a: GO:0009755 ! hormone-mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:36:29Z [Term] id: GO:0002155 name: regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of a thyroid hormone mediated signaling pathway." [GOC:hjd] is_a: GO:0035466 ! regulation of signaling pathway is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:37:46Z [Term] id: GO:0002156 name: negative regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0035467 ! negative regulation of signaling pathway is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: negatively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:41:48Z [Term] id: GO:0002157 name: positive regulation of thyroid hormone mediated signaling pathway namespace: biological_process def: "Any process that increases the frequency, rate or extent of thyroid hormone mediated signaling pathway." [GOC:hjd] is_a: GO:0002155 ! regulation of thyroid hormone mediated signaling pathway is_a: GO:0035468 ! positive regulation of signaling pathway is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway relationship: positively_regulates GO:0002154 ! thyroid hormone mediated signaling pathway created_by: hjd creation_date: 2009-11-19T12:42:57Z [Term] id: GO:0002158 name: osteoclast proliferation namespace: biological_process def: "The multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, which typically differentiates from monocytes." [CL:0000092, GOC:hjd] is_a: GO:0070661 ! leukocyte proliferation created_by: hjd creation_date: 2010-02-03T01:50:37Z [Term] id: GO:0002159 name: desmosome assembly namespace: biological_process def: "A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0007043 ! cell-cell junction assembly created_by: hjd creation_date: 2010-02-09T10:46:30Z [Term] id: GO:0002160 name: desmosome maintenance namespace: biological_process def: "The maintenance of a desmosome. A desmosome is a patch-like intercellular junctions found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an interspace of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm." [GOC:hjd, ISBN:0198506732] comment: Desmosomes link two cells together; hemidesmosomes attach one cell to the extracellular matrix. is_a: GO:0045217 ! cell-cell junction maintenance created_by: hjd creation_date: 2010-02-09T10:50:59Z [Term] id: GO:0002161 name: aminoacyl-tRNA editing activity namespace: molecular_function def: "The hydrolysis of an incorrectly aminoacylated tRNA." [GOC:hjd, PMID:14663147, PMID:16087889] synonym: "amino acid proofreading activity" RELATED [] synonym: "aminoacyl-tRNA hydrolysis activity" RELATED [] is_a: GO:0004091 ! carboxylesterase activity relationship: part_of GO:0006450 ! regulation of translational fidelity created_by: hjd creation_date: 2010-02-12T03:06:56Z [Term] id: GO:0002162 name: dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with dystroglycan. Dystroglycan is glycoprotein found in non-muscle tissues as well as in muscle tissues, often in association with dystrophin. The native dystroglycan cleaved into two non-covalently associated subunits, alpha (N-terminal) and beta (C-terminal)." [GOC:hjd] is_a: GO:0001948 ! glycoprotein binding created_by: hjd creation_date: 2010-02-22T02:17:58Z [Term] id: GO:0002163 name: alpha-dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with alpha-dystroglycan. Alpha-dystroglycan is extracellular protein derived from cleavage of dystroglycan." [GOC:hjd] is_a: GO:0002162 ! dystroglycan binding created_by: hjd creation_date: 2010-02-22T02:19:16Z [Term] id: GO:0002164 name: larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. The larva is the early, immature form of any animal when more or less of a metamorphosis takes place, before the assumption of the mature shape." [GOC:jid, http://cancerweb.ncl.ac.uk] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002165 name: instar larval or pupal development namespace: biological_process def: "The process whose specific outcome is the progression of the instar larva or pupa over time, from its formation to the mature structure. An example of this process is found in Drosophila melanogaster." [GOC:jid, GOC:mtg_sensu] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0002166 name: beta-dystroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with beta-dystroglycan. Beta-dystroglycan is a transmembrane protein derived from cleavage of dystroglycan." [GOC:hjd] is_a: GO:0002162 ! dystroglycan binding created_by: hjd creation_date: 2010-02-22T02:20:08Z [Term] id: GO:0002167 name: VRK3/VHR/ERK complex namespace: cellular_component def: "A ternary complex consisting of VRK3 , VHR (Dusp3), and ERK1 (Mapk3) existing in neuronal cells, and is involved in regulation of the ERK signaling pathway." [GOC:hjd, PMID:16845380] is_a: GO:0043234 ! protein complex created_by: hjd creation_date: 2010-03-04T01:15:05Z [Term] id: GO:0002168 name: instar larval development namespace: biological_process def: "The process whose specific outcome is the progression of the larva over time, from its formation to the mature structure. This begins with the newly hatched first-instar larva, through its maturation to the end of the last larval stage. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0002164 ! larval development is_a: GO:0002165 ! instar larval or pupal development [Term] id: GO:0002169 name: 3-methylcrotonyl-CoA carboxylase complex, mitochondrial namespace: cellular_component def: "A heterodimeric complex having 3-methylcrotonyl-CoA carboxylase activity. The alpha subunit has a covalently bound biotin essential for the ATP-dependent carboxylation. The beta subunit possess carboxyltransferase activity which presumably is essential for binding to 3-methylcrotonyl-CoA." [GOC:hjd, PMID:15868465] is_a: GO:0043234 ! protein complex is_a: GO:0044429 ! mitochondrial part created_by: hjd creation_date: 2010-03-15T04:58:08Z [Term] id: GO:0002170 name: high affinity IgA receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0019766 ! IgA receptor activity created_by: hjd creation_date: 2010-05-06T05:00:11Z [Term] id: GO:0002171 name: low affinity IgA receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgA isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0019766 ! IgA receptor activity created_by: hjd creation_date: 2010-05-06T05:01:41Z [Term] id: GO:0002172 name: high affinity IgM receptor activity namespace: molecular_function def: "Combining with high affinity with an immunoglobulin of an IgM isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0001793 ! IgM receptor activity created_by: hjd creation_date: 2010-05-06T05:03:26Z [Term] id: GO:0002173 name: low affinity IgM receptor activity namespace: molecular_function def: "Combining with low affinity with an immunoglobulin of an IgM isotype via the Fc region to initiate a change in cell activity." [GOC:hjd] is_a: GO:0001793 ! IgM receptor activity created_by: hjd creation_date: 2010-05-06T05:04:24Z [Term] id: GO:0002200 name: somatic diversification of immune receptors namespace: biological_process def: "The somatic process allowing for the production of immune receptors whose specificity is not encoded in the germline genomic sequences." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] comment: Note that this process covers somatic recombination, gene conversion, hypermutation, N-region addition, and alternate splicing processes of immune receptor diversification. is_a: GO:0002376 ! immune system process relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002201 name: somatic diversification of DSCAM-based immune receptors namespace: biological_process def: "The somatic process by means of which sequence diversity of the DSCAM-based immune receptors of insects is generated." [GOC:add, PMID:16261174] comment: Note that this type of immune receptor may not be limited to insects. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002202 name: somatic diversification of variable lymphocyte receptors of jawless fish namespace: biological_process def: "The somatic process by means of which sequence diversity of the variable lymphocyte receptors (VLR) of jawless fish is generated." [GOC:add, PMID:16373579] comment: Note that jawless fish refers to both lampreys (Petremyzontidae, ncbi_taxonomy_id:7746) and hagfish (Myxinidae, ncbi_taxonomy_id:7762). is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002203 name: proteolysis by cytosolic proteases associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by cytosolic resident proteases during antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] comment: Note that a separate term covers proteolysis by the proteasome complex (proteasomal proteolysis associated with antigen processing and presentation ; GO:0002497). is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002204 name: somatic recombination of immunoglobulin genes involved in immune response namespace: biological_process def: "The process by which immunoglobulin genes are formed through recombination of the germline genetic elements, also known as immunoglobulin gene segments, within a single locus following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic recombination of antibody genes during immune response" RELATED [] synonym: "somatic recombination of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002205 name: somatic hypermutation of immunoglobulin genes involved in immune response namespace: biological_process def: "Mutations occurring somatically that result in amino acid changes in the rearranged V regions of immunoglobulins following the induction of and contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11205333, PMID:14991701] synonym: "somatic hypermutation of antibody genes during immune response" RELATED [] synonym: "somatic hypermutation of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response is_a: GO:0016446 ! somatic hypermutation of immunoglobulin genes relationship: part_of GO:0002344 ! B cell affinity maturation [Term] id: GO:0002206 name: gene conversion of immunoglobulin genes namespace: biological_process def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes" EXACT [] is_a: GO:0002565 ! somatic diversification of immune receptors via gene conversion is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002207 name: gene conversion of immunoglobulin genes involved in immune response namespace: biological_process def: "The somatic process by which immunoglobulin genes are diversified through the mechanism of gene conversion following the induction of and contributing to an immune response." [GOC:add, PMID:14991701] synonym: "gene conversion of antibody genes during immune response" RELATED [] synonym: "gene conversion of immunoglobulin genes during immune response" RELATED [GOC:dph] is_a: GO:0002206 ! gene conversion of immunoglobulin genes is_a: GO:0002208 ! somatic diversification of immunoglobulins involved in immune response [Term] id: GO:0002208 name: somatic diversification of immunoglobulins involved in immune response namespace: biological_process def: "The somatic process by means of which sequence diversity of immunoglobulins is generated after the induction and contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14991701] synonym: "somatic diversification of antibodies during immune response" RELATED [] synonym: "somatic diversification of immunoglobulins during immune response" RELATED [GOC:dph] is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002209 name: behavioral defense response namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat to that organism." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural defense response" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0007610 ! behavior [Term] id: GO:0002210 name: behavioral response to wounding namespace: biological_process def: "A behavioral response resulting from wounding." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "behavioural response to wounding" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009611 ! response to wounding [Term] id: GO:0002211 name: behavioral defense response to insect namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "behavioural defense response to insect" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002213 ! defense response to insect [Term] id: GO:0002212 name: behavioral defense response to nematode namespace: biological_process def: "A behavioral response seeking to protect an organism from an a perceived external threat from a nematode or nematodes to that organism." [GOC:add, PMID:14506883] synonym: "behavioural defense response to nematode" EXACT [] is_a: GO:0002209 ! behavioral defense response is_a: GO:0002215 ! defense response to nematode [Term] id: GO:0002213 name: defense response to insect namespace: biological_process alt_id: GO:0002214 def: "A response to protect an organism from a directly detected or perceived external threat from an insect or insects to that organism." [GOC:add] synonym: "physiological defense response to insect" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009625 ! response to insect [Term] id: GO:0002215 name: defense response to nematode namespace: biological_process alt_id: GO:0002216 def: "A response to protect an organism from a directly detected or perceived external threat from a nematode or nematodes, which results in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:add, PMID:11516579, PMID:14506883] synonym: "physiological defense response to nematode" EXACT [] is_a: GO:0006952 ! defense response is_a: GO:0009624 ! response to nematode [Term] id: GO:0002218 name: activation of innate immune response namespace: biological_process alt_id: GO:0002219 def: "Any process that initiates an innate immune response. Innate immune responses are defense responses mediated by germline encoded components that directly recognize components of potential pathogens. Examples of this process include activation of the hypersensitive response of Arabidopsis thaliana and activation of any NOD or TLR signaling pathway in vertebrate species." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:16177805] comment: This term was added by GO_REF:0000022. is_a: GO:0002253 ! activation of immune response is_a: GO:0045089 ! positive regulation of innate immune response [Term] id: GO:0002220 name: innate immune response activating cell surface receptor signaling pathway namespace: biological_process def: "Any series of molecular signals leading to activation of the innate immune response generated as a consequence of binding to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "activation of innate immune response by cell surface receptor signaling pathway" EXACT [] synonym: "innate immune response activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002221 name: pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface or intracellular pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "PAMP receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "pathogen receptor signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "pathogen receptor signalling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] synonym: "PRR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology", PMID:15199967, PMID:15728447] is_a: GO:0002758 ! innate immune response-activating signal transduction [Term] id: GO:0002222 name: stimulatory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a killer cell immunoglobulin-like receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "stimulatory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "stimulatory KIR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002223 name: stimulatory C-type lectin receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a C-type lectin receptor capable of cellular activation." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "stimulatory C-type lectin receptor signalling pathway" EXACT [] synonym: "stimulatory Ly49 family receptor signaling pathway." NARROW [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway [Term] id: GO:0002224 name: toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] comment: This term was added by GO_REF:0000022. Note that the vertebrate toll-like receptors, unlike the Drosophila Toll molecule, directly bind their ligands. The Drosophila Toll molecule requires the Sptzle factor to bind microbial ligands and then the receptor in order to initiate innate immune responses. synonym: "TLR signaling pathway" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "toll-like receptor signalling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002225 name: positive regulation of antimicrobial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide production." [GOC:add, PMID:11807545] synonym: "activation of antimicrobial peptide production" NARROW [] synonym: "antimicrobial peptide induction" EXACT [] synonym: "stimulation of antimicrobial peptide production" NARROW [] synonym: "up regulation of antimicrobial peptide production" EXACT [] synonym: "up-regulation of antimicrobial peptide production" EXACT [] synonym: "upregulation of antimicrobial peptide production" EXACT [] is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002775 ! antimicrobial peptide production relationship: positively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002227 name: innate immune response in mucosa namespace: biological_process def: "Any process of the innate immune response that takes place in the mucosal tissues." [GOC:add, PMID:10719665, PMID:15971105] is_a: GO:0002385 ! mucosal immune response is_a: GO:0045087 ! innate immune response [Term] id: GO:0002228 name: natural killer cell mediated immunity namespace: biological_process def: "The promotion of an immune response by natural killer cells through direct recognition of target cells or through the release of cytokines." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "NK cell mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0045087 ! innate immune response [Term] id: GO:0002229 name: defense response to oomycetes namespace: biological_process def: "Reactions triggered in response to the presence of oomycetes that act to protect the cell or organism." [GOC:add, PMID:16497589] is_a: GO:0002239 ! response to oomycetes is_a: GO:0006952 ! defense response [Term] id: GO:0002230 name: positive regulation of defense response to virus by host namespace: biological_process def: "Any host process that results in the promotion of antiviral immune response mechanisms, thereby limiting viral replication." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of antiviral response by host" NARROW [] synonym: "positive regulation of antiviral response by host" EXACT [GOC:dph, GOC:tb] synonym: "stimulation of antiviral response by host" NARROW [] synonym: "up regulation of antiviral response by host" EXACT [] synonym: "up-regulation of antiviral response by host" EXACT [] synonym: "upregulation of antiviral response by host" EXACT [] is_a: GO:0050691 ! regulation of defense response to virus by host [Term] id: GO:0002231 name: detection of oomycetes namespace: biological_process def: "The series of events in which a stimulus from an oomycetes is received and converted into a molecular signal." [GOC:add, PMID:15922649] is_a: GO:0002239 ! response to oomycetes is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002232 name: leukocyte chemotaxis involved in inflammatory response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus contributing to an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell chemotaxis during inflammatory response" RELATED [] synonym: "leucocyte chemotaxis during inflammatory response" RELATED [] synonym: "leukocyte chemotaxis during inflammatory response" RELATED [GOC:dph] is_a: GO:0002523 ! leukocyte migration involved in inflammatory response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002233 name: leukocyte chemotaxis involved in immune response namespace: biological_process def: "The movement of an immune cell in response to an external stimulus a part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell chemotaxis during immune response" EXACT [] synonym: "leucocyte chemotaxis during immune response" EXACT [] is_a: GO:0002522 ! leukocyte migration involved in immune response is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002234 name: detection of endoplasmic reticulum overloading namespace: biological_process def: "The series of events in which a stimulus generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum is received and converted into a molecular signal." [GOC:add, PMID:10390516] synonym: "detection of ER overloading" EXACT [] is_a: GO:0006983 ! ER overload response is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002235 name: detection of unfolded protein namespace: biological_process def: "The series of events in which an unfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511, PMID:7765470] is_a: GO:0006986 ! response to unfolded protein is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002236 name: detection of misfolded protein namespace: biological_process def: "The series of events in which a misfolded protein stimulus is received and converted into a molecular signal." [GOC:add, PMID:15226511] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0051788 ! response to misfolded protein [Term] id: GO:0002237 name: response to molecule of bacterial origin namespace: biological_process def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of bacterial origin such as peptides derived from bacterial flagellin." [GOC:rl, GOC:sm] synonym: "response to bacteria associated molecule" EXACT [] synonym: "response to bacterial associated molecule" EXACT [] synonym: "response to bacterium associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009617 ! response to bacterium [Term] id: GO:0002238 name: response to molecule of fungal origin namespace: biological_process def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of fungal origin such as chito-octamer oligosaccharide." [GOC:rl, GOC:sm] synonym: "response to fungus associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0010033 ! response to organic substance relationship: part_of GO:0009620 ! response to fungus [Term] id: GO:0002239 name: response to oomycetes namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an oomycetes." [GOC:add, PMID:16497589] is_a: GO:0051707 ! response to other organism [Term] id: GO:0002240 name: response to molecule of oomycetes origin namespace: biological_process def: "A change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus by molecules of oomycetes origin." [GOC:rl, GOC:sm] synonym: "response to oomycetes associated molecule" EXACT [] is_a: GO:0009607 ! response to biotic stimulus relationship: part_of GO:0002239 ! response to oomycetes [Term] id: GO:0002241 name: response to parasitic plant namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic plant." [GOC:add, PMID:16547862] is_a: GO:0009608 ! response to symbiont [Term] id: GO:0002242 name: defense response to parasitic plant namespace: biological_process def: "Reactions triggered in response to the presence of a parasitic plant that act to protect an organism." [GOC:add] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0006952 ! defense response [Term] id: GO:0002243 name: detection of parasitic plant namespace: biological_process def: "The series of events in which a stimulus from a parasitic plant is received and converted into a molecular signal." [GOC:add, PMID:16547862] is_a: GO:0002241 ! response to parasitic plant is_a: GO:0009602 ! detection of symbiont [Term] id: GO:0002244 name: hemopoietic progenitor cell differentiation namespace: biological_process def: "The process whereby precursor cell type acquires the specialized features of a hemopoietic progenitor cell, a class of cell types including myeloid progenitor cells and lymphoid progenitor cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] synonym: "haematopoietic progenitor cell differentiation" EXACT [] synonym: "haemopoietic progenitor cell differentiation" EXACT [] synonym: "hematopoietic progenitor cell differentiation" RELATED [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002246 name: wound healing involved in inflammatory response namespace: biological_process def: "The series of events that restore integrity to damaged tissue that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "healing during inflammatory response" RELATED [GOC:dph] synonym: "inflammatory response wound healing" RELATED [GOC:dph] is_a: GO:0042060 ! wound healing relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002247 name: clearance of damaged tissue involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to removal of necrotic debris that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "clearance of damaged tissue during inflammatory response" RELATED [GOC:dph] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002248 name: connective tissue replacement involved in inflammatory response wound healing namespace: biological_process def: "The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared that contribute to an inflammatory response." [GOC:jal, ISBN:0721601871] synonym: "connective tissue replacement during inflammatory response" RELATED [GOC:dph] synonym: "fibrosis during inflammatory response" NARROW [ISBN:0721601871] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0002246 ! wound healing involved in inflammatory response [Term] id: GO:0002249 name: lymphocyte anergy namespace: biological_process def: "Any process contributing to lymphocyte anergy, a state of functional inactivation." [GOC:add] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002250 name: adaptive immune response namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory)." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "acquired immune response" EXACT [ISBN:068340007X "Stedman's Medical Dictionary"] xref: Wikipedia:Adaptive_immune_system is_a: GO:0006955 ! immune response [Term] id: GO:0002251 name: organ or tissue specific immune response namespace: biological_process def: "An immune response taking place in an organ or tissues such as the liver, brain, mucosa, or nervous system tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. synonym: "immune response in organ or tissue" EXACT [] is_a: GO:0006955 ! immune response [Term] id: GO:0002252 name: immune effector process namespace: biological_process def: "Any process of the immune system that occurs as part of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002253 name: activation of immune response namespace: biological_process def: "Any process that initiates an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process is_a: GO:0050778 ! positive regulation of immune response [Term] id: GO:0002254 name: kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell that occur as a result of by-products of tissue damage, including collagen, cartilage, and basement membrane. The ultimate product of the kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:jal, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002255 name: tissue kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell initiated by the action of tissue (glandular) kallikreins on low molecular weight kininogen in response to tissue damage. Tissue kallikreins are present in glandular tissues and their fluids, such as the salivary glands, sweat glands, pancreas, and kidney. The ultimate products of the tissue kallikrein-kinin cascade include kallidin and bradykinin, agents known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, PMID:11842287, PMID:14501145] synonym: "glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002256 name: regulation of kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the kinin cascade." [GOC:jal] is_a: GO:0002673 ! regulation of acute inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002254 ! kinin cascade relationship: regulates GO:0002254 ! kinin cascade [Term] id: GO:0002257 name: negative regulation of kinin cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "down regulation of kinin cascade" EXACT [] synonym: "down-regulation of kinin cascade" EXACT [] synonym: "downregulation of kinin cascade" EXACT [] synonym: "inhibition of kinin cascade" NARROW [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002674 ! negative regulation of acute inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002254 ! kinin cascade relationship: negatively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002258 name: positive regulation of kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the kinin cascade." [GOC:jal] synonym: "activation of kinin cascade" NARROW [] synonym: "stimulation of kinin cascade" NARROW [] synonym: "up regulation of kinin cascade" EXACT [] synonym: "up-regulation of kinin cascade" EXACT [] synonym: "upregulation of kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade is_a: GO:0002675 ! positive regulation of acute inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002254 ! kinin cascade relationship: positively_regulates GO:0002254 ! kinin cascade [Term] id: GO:0002259 name: endothelial cell activation within high endothelial venule involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell within a high endothelial venule resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endothelial cell activation within high endothelial venule during immune response" RELATED [GOC:tb] is_a: GO:0002264 ! endothelial cell activation involved in immune response [Term] id: GO:0002260 name: lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15826826, PMID:16319493, PMID:16551252, PMID:16551262] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002261 name: mucosal lymphocyte homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of lymphocytes such that the total number of lymphocytes within the mucosal tissue of an organism is stable over time in the absence of an outside stimulus." [GOC:add, PMID:15609020] is_a: GO:0002260 ! lymphocyte homeostasis [Term] id: GO:0002262 name: myeloid cell homeostasis namespace: biological_process def: "The process of regulating the proliferation and elimination of myeloid cells such that the total number of myeloid cells within a whole or part of an organism is stable over time in the absence of an outside stimulus." [GOC:add] is_a: GO:0001776 ! leukocyte homeostasis [Term] id: GO:0002263 name: cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001775 ! cell activation relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002264 name: endothelial cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an endothelial cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endothelial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0042118 ! endothelial cell activation [Term] id: GO:0002265 name: astrocyte activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of an astrocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:11138785] synonym: "astrocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0048143 ! astrocyte activation [Term] id: GO:0002266 name: follicular dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15606789] is_a: GO:0001775 ! cell activation [Term] id: GO:0002267 name: follicular dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a follicular dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15606789] synonym: "follicular dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0002266 ! follicular dendritic cell activation [Term] id: GO:0002268 name: follicular dendritic cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized precursor cell acquires the specialized features of a follicular dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002266 ! follicular dendritic cell activation is_a: GO:0030154 ! cell differentiation [Term] id: GO:0002269 name: leukocyte activation involved in inflammatory response namespace: biological_process def: "A change in the morphology or behavior of a leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell activation during inflammatory response" RELATED [] synonym: "leukocyte activation during inflammatory response" RELATED [GOC:tb] is_a: GO:0045321 ! leukocyte activation relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002270 name: plasmacytoid dendritic cell activation namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, PMID:15990333, PMID:16174109] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002271 name: plasmacytoid dendritic cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a plasmacytoid dendritic cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15990333, PMID:16174109] synonym: "plasmacytoid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002272 name: plasmacytoid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process whereby an immature plasmacytoid dendritic cell acquires the specialized features of a mature plasmacytoid dendritic cell contributing to an immune response." [GOC:add, PMID:15990333] synonym: "plasmacytoid dendritic cell differentiation during immune response" RELATED [GOC:dph] is_a: GO:0002271 ! plasmacytoid dendritic cell activation involved in immune response is_a: GO:0002273 ! plasmacytoid dendritic cell differentiation [Term] id: GO:0002273 name: plasmacytoid dendritic cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell." [GOC:add, PMID:15990333, PMID:16174108] is_a: GO:0002270 ! plasmacytoid dendritic cell activation is_a: GO:0002521 ! leukocyte differentiation [Term] id: GO:0002274 name: myeloid leukocyte activation namespace: biological_process def: "A change in the morphology or behavior of a myeloid leukocyte resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid leucocyte activation" EXACT [] is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002275 name: myeloid cell activation involved in immune response namespace: biological_process def: "A change in the morphology or behavior of a myeloid cell resulting from exposure to an activating factor such as a cellular or soluble ligand, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002274 ! myeloid leukocyte activation is_a: GO:0002366 ! leukocyte activation involved in immune response [Term] id: GO:0002276 name: basophil activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a basophil resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the basophil has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "basophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045575 ! basophil activation [Term] id: GO:0002277 name: myeloid dendritic cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a myeloid dendritic cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid dendritic cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001773 ! myeloid dendritic cell activation is_a: GO:0002275 ! myeloid cell activation involved in immune response [Term] id: GO:0002278 name: eosinophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a eosinophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "eosinophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0043307 ! eosinophil activation [Term] id: GO:0002279 name: mast cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "mast cell activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0045576 ! mast cell activation [Term] id: GO:0002280 name: monocyte activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16551245] synonym: "monocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042117 ! monocyte activation [Term] id: GO:0002281 name: macrophage activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "macrophage activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042116 ! macrophage activation [Term] id: GO:0002282 name: microglial cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a microglial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "microglial cell activation during immune response" RELATED [GOC:tb] is_a: GO:0001774 ! microglial cell activation is_a: GO:0002281 ! macrophage activation involved in immune response [Term] id: GO:0002283 name: neutrophil activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "neutrophil activation during immune response" RELATED [GOC:tb] is_a: GO:0002275 ! myeloid cell activation involved in immune response is_a: GO:0042119 ! neutrophil activation [Term] id: GO:0002284 name: myeloid dendritic cell differentiation involved in immune response namespace: biological_process def: "The process whereby an immature myeloid dendritic cell acquires the specialized features of a mature myeloid dendritic cell as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "myeloid dendritic cell differentiation during immune response" RELATED [GOC:tb] is_a: GO:0002277 ! myeloid dendritic cell activation involved in immune response is_a: GO:0043011 ! myeloid dendritic cell differentiation [Term] id: GO:0002285 name: lymphocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a lymphocyte resulting from exposure to a specific antigen, mitogen, cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "lymphocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002366 ! leukocyte activation involved in immune response is_a: GO:0046649 ! lymphocyte activation [Term] id: GO:0002286 name: T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell activation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte activation during immune response" RELATED [] synonym: "T-cell activation during immune response" RELATED [] synonym: "T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042110 ! T cell activation [Term] id: GO:0002287 name: alpha-beta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of an alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T cell activation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte activation during immune response" RELATED [] synonym: "alpha-beta T-cell activation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046631 ! alpha-beta T cell activation [Term] id: GO:0002288 name: NK T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature natural killer T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte activation during immune response" RELATED [] synonym: "natural killer T-cell activation during immune response" RELATED [] synonym: "natural killer T-lymphocyte activation during immune response" RELATED [] synonym: "NK T cell activation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte activation during immune response" RELATED [] synonym: "NK T-cell activation during immune response" RELATED [] synonym: "NK T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0051132 ! NK T cell activation [Term] id: GO:0002289 name: NK T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a NK T cell population by cell division as part of an immune response." [GOC:add, PMID:15771592] synonym: "natural killer T lymphocyte proliferation during immune response" RELATED [] synonym: "natural killer T-cell proliferation during immune response" RELATED [] synonym: "natural killer T-lymphocyte proliferation during immune response" RELATED [] synonym: "NK T cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK T lymphocyte proliferation during immune response" RELATED [] synonym: "NK T-cell proliferation during immune response" RELATED [] synonym: "NK T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0001866 ! NK T cell proliferation is_a: GO:0002288 ! NK T cell activation involved in immune response is_a: GO:0002310 ! alpha-beta T cell proliferation involved in immune response [Term] id: GO:0002290 name: gamma-delta T cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a gamma-delta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:8717523] synonym: "gamma-delta T cell activation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte activation during immune response" RELATED [] synonym: "gamma-delta T-cell activation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte activation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0046629 ! gamma-delta T cell activation [Term] id: GO:0002291 name: T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell namespace: biological_process def: "The change in morphology and behavior of a mature or immature T cell resulting from exposure to an antigen for which its T cell receptor is specific bound to an MHC molecule on an antigen presenting cell, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] synonym: "T-lymphocyte activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell" EXACT [] is_a: GO:0002286 ! T cell activation involved in immune response [Term] id: GO:0002292 name: T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell differentiation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte differentiation during immune response" RELATED [] synonym: "T-cell differentiation during immune response" RELATED [] synonym: "T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0030217 ! T cell differentiation [Term] id: GO:0002293 name: alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell during an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002294 name: CD4-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD4-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation [Term] id: GO:0002295 name: T-helper cell lineage commitment namespace: biological_process def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper cell, a CD4-positive, alpha-beta T cell specialized to promote various immunological processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper cell fate commitment" EXACT [] synonym: "Th0 lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] synonym: "Thp lineage commitment" RELATED [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042093 ! T-helper cell differentiation [Term] id: GO:0002296 name: T-helper 1 cell lineage commitment namespace: biological_process def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 1 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper 1 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th1 cell lineage commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th1 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045063 ! T-helper 1 cell differentiation [Term] id: GO:0002297 name: T-helper 2 cell lineage commitment namespace: biological_process def: "The process whereby a CD4-positive, alpha-beta T cell becomes committed to becoming a T-helper 2 cell, a CD4-positive, alpha-beta T cell specialized to promote immunological processes often associated with resistance to extracellular organisms such as helminths, enhanced production of particular antibody isotypes, and pathological conditions such as allergy." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T-helper 2 cell fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] synonym: "Th2 fate commitment" EXACT [ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002295 ! T-helper cell lineage commitment relationship: part_of GO:0045064 ! T-helper 2 cell differentiation [Term] id: GO:0002298 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave CD4-positive, alpha-beta T cell acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell as part of an immune response." [GOC:add, PMID:12093005] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation during immune response" RELATED [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002294 ! CD4-positive, alpha-beta T cell differentiation involved in immune response is_a: GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002299 name: alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of an alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002300 name: CD8-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002301 name: CD4-positive, alpha-beta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, alpha-beta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD4-positive, alpha-beta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, alpha-beta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002299 ! alpha-beta intraepithelial T cell differentiation is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation [Term] id: GO:0002302 name: CD8-positive, alpha-beta T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave CD8-positive, alpha-beta T cell acquires the specialized features of an effector, regulatory, or memory T cell as part of an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, alpha-beta T cell differentiation during immune response" RELATED [GOC:tb] synonym: "CD8-positive, alpha-beta T lymphocyte differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-cell differentiation during immune response" RELATED [] synonym: "CD8-positive, alpha-beta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002293 ! alpha-beta T cell differentiation involved in immune response is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation [Term] id: GO:0002303 name: gamma-delta T cell differentiation involved in immune response namespace: biological_process def: "The process whereby an antigenically nave gamma-delta T cell acquires the specialized features of an effector, regulatory, or memory T cell and contributes to an immune response. Effector T cells include cells which provide T cell help or exhibit cytotoxicity towards other cells." [GOC:add] synonym: "gamma-delta T cell differentiation during immune response" RELATED [GOC:dph] synonym: "gamma-delta T lymphocyte differentiation during immune response" RELATED [] synonym: "gamma-delta T-cell differentiation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002292 ! T cell differentiation involved in immune response is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002304 name: gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002305 name: CD8-positive, gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD8-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002306 name: CD4-positive gamma-delta intraepithelial T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, gamma-delta intraepithelial T cell. Intraepithelial T cells are found among epithelial cells in mucosal areas and have distinct phenotypes and developmental pathways." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD4-positive, gamma-delta intraepithelial T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-cell differentiation" EXACT [] synonym: "CD4-positive, gamma-delta intraepithelial T-lymphocyte differentiation" EXACT [] is_a: GO:0002304 ! gamma-delta intraepithelial T cell differentiation [Term] id: GO:0002307 name: CD8-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta regulatory T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002308 name: CD8-positive, alpha-beta cytotoxic T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD8-positive, alpha-beta cytotoxic T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "CD8-positive, alpha-beta cytotoxic T lymphocyte differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-cell differentiation" EXACT [] synonym: "CD8-positive, alpha-beta cytotoxic T-lymphocyte differentiation" EXACT [] is_a: GO:0043374 ! CD8-positive, alpha-beta T cell differentiation is_a: GO:0045065 ! cytotoxic T cell differentiation [Term] id: GO:0002309 name: T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T cell proliferation during immune response" RELATED [GOC:tb] synonym: "T lymphocyte proliferation during immune response" RELATED [] synonym: "T-cell proliferation during immune response" RELATED [] synonym: "T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002286 ! T cell activation involved in immune response is_a: GO:0042098 ! T cell proliferation [Term] id: GO:0002310 name: alpha-beta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of an alpha-beta T cell population by cell division as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "alpha-beta T lymphocyte proliferation during immune response" RELATED [] synonym: "alpha-beta T-cell proliferation during immune response" RELATED [] synonym: "alpha-beta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002287 ! alpha-beta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046633 ! alpha-beta T cell proliferation [Term] id: GO:0002311 name: gamma-delta T cell proliferation involved in immune response namespace: biological_process def: "The expansion of a gamma-delta T cell population by cell division as part of an immune response." [GOC:add] synonym: "gamma-delta T cell proliferation during immune response" RELATED [GOC:tb] synonym: "gamma-delta T lymphocyte proliferation during immune response" RELATED [] synonym: "gamma-delta T-cell proliferation during immune response" RELATED [] synonym: "gamma-delta T-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002290 ! gamma-delta T cell activation involved in immune response is_a: GO:0002309 ! T cell proliferation involved in immune response is_a: GO:0046630 ! gamma-delta T cell proliferation [Term] id: GO:0002312 name: B cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a mature or immature B cell during an immune response, resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific." [GOC:jal] synonym: "B cell activation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte activation during immune response" RELATED [] synonym: "B-cell activation during immune response" RELATED [] synonym: "B-lymphocyte activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0042113 ! B cell activation [Term] id: GO:0002313 name: mature B cell differentiation involved in immune response namespace: biological_process def: "The process whereby a nave B cell acquires the specialized features of a mature or memory B cell during an immune response." [GOC:jal] synonym: "mature B cell differentiation during immune response" RELATED [GOC:tb] synonym: "mature B lymphocyte differentiation during immune response" RELATED [] synonym: "mature B-cell differentiation during immune response" RELATED [] synonym: "mature B-lymphocyte differentiation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0002335 ! mature B cell differentiation [Term] id: GO:0002314 name: germinal center B cell differentiation namespace: biological_process def: "The process whereby a B cell in the spleen acquires the specialized features of a germinal center B cell. Germinal center B cells are rapidly cycling B cells which have downregulated IgD expression and exhibit high levels of binding by peanut agglutinin (PNA)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "germinal center B lymphocyte differentiation" EXACT [] synonym: "germinal center B-cell differentiation" EXACT [] synonym: "germinal center B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002315 name: marginal zone B cell differentiation namespace: biological_process def: "The process whereby a B cell in the spleen acquires the specialized features of a marginal zone B cell. Marginal zone B cells are localized in a distinct anatomical region of the spleen that represents the major antigen-filtering and scavenging area (by specialized macrophages resident there). It appears that they are preselected to express a BCR repertoire similar to B-1 B cells, biased toward bacterial cell wall constituents and senescent self-components (such as oxidized LDL)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "marginal zone B lymphocyte differentiation" EXACT [] synonym: "marginal zone B-cell differentiation" EXACT [] synonym: "marginal zone B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002316 name: follicular B cell differentiation namespace: biological_process def: "The process whereby a B cell in the spleen acquires the specialized features of a follicular B cell. Follicular B cells are major population of mature recirculating B cells in the spleen and are located in the B-cell follicle region." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "follicular B lymphocyte differentiation" EXACT [] synonym: "follicular B-cell differentiation" EXACT [] synonym: "follicular B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002317 name: plasma cell differentiation namespace: biological_process def: "The process whereby a B cell acquires the specialized features of a plasma cell. A plasma cell is a lymphocyte which develops from a B cell and produces high amounts of antibody." [GOC:jal] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002318 name: myeloid progenitor cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a myeloid progenitor cell. Myeloid progenitor cells include progenitor cells for any of the myeloid lineages." [GOC:add, PMID:16551264] is_a: GO:0002244 ! hemopoietic progenitor cell differentiation [Term] id: GO:0002319 name: memory B cell differentiation namespace: biological_process def: "The process whereby a B cell acquires the specialized features of a memory B cell. Memory B cells are cells that can respond rapidly to antigen re-exposure by production of high-affinity antibody." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "memory B lymphocyte differentiation" EXACT [] synonym: "memory B-cell differentiation" EXACT [] synonym: "memory B-lymphocyte differentiation" EXACT [] is_a: GO:0002313 ! mature B cell differentiation involved in immune response [Term] id: GO:0002320 name: lymphoid progenitor cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a lymphoid progenitor cell. Lymphoid progenitor cells include progenitor cells for any of the lymphoid lineages." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002244 ! hemopoietic progenitor cell differentiation [Term] id: GO:0002321 name: natural killer cell progenitor differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a natural killer cell progenitor." [GOC:add, PMID:16551251, PMID:16551264] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002322 name: B cell proliferation involved in immune response namespace: biological_process def: "The expansion of a B cell population by cell division following B cell activation during an immune response." [GOC:jal] synonym: "B cell proliferation during immune response" RELATED [GOC:tb] synonym: "B lymphocyte proliferation during immune response" RELATED [] synonym: "B-cell proliferation during immune response" RELATED [] synonym: "B-lymphocyte proliferation during immune response" RELATED [] is_a: GO:0002312 ! B cell activation involved in immune response is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002323 name: natural killer cell activation involved in immune response namespace: biological_process def: "The change in morphology and behavior of a natural killer cell resulting from exposure a cytokine, chemokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell activation during immune response" RELATED [GOC:tb] synonym: "NK cell activation during immune response" RELATED [] is_a: GO:0002285 ! lymphocyte activation involved in immune response is_a: GO:0030101 ! natural killer cell activation [Term] id: GO:0002324 name: natural killer cell proliferation involved in immune response namespace: biological_process def: "The expansion of a natural killer cell population by cell division as part of an immune response." [GOC:add, PMID:15032583] synonym: "natural killer cell proliferation during immune response" RELATED [GOC:tb] synonym: "NK cell proliferation during immune response" RELATED [] is_a: GO:0001787 ! natural killer cell proliferation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002325 name: natural killer cell differentiation involved in immune response namespace: biological_process def: "The process whereby a nave natural killer cell acquires the specialized features of an effector natural killer T cell as part of an immune response." [GOC:add, PMID:11698225] synonym: "natural killer cell differentiation during immune response" RELATED [GOC:tb] synonym: "NK cell differentiation during immune response" RELATED [] is_a: GO:0001779 ! natural killer cell differentiation is_a: GO:0002323 ! natural killer cell activation involved in immune response [Term] id: GO:0002326 name: B cell lineage commitment namespace: biological_process def: "The process whereby a lymphoid progenitor cell becomes committed to become any type of B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte lineage commitment" EXACT [] synonym: "B-cell lineage commitment" EXACT [] synonym: "B-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002327 name: immature B cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of an immature B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551251] synonym: "immature B lymphocyte differentiation" EXACT [] synonym: "immature B-cell differentiation" EXACT [] synonym: "immature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002328 name: pro-B cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a pro-B cell. Pro-B cells are the earliest stage of the B cell lineage and undergo heavy chain D and J gene rearrangements, although they are not fully committed." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-B lymphocyte differentiation" EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation [Term] id: GO:0002329 name: pre-B cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a pre-B cell. Pre-B cells follow the pro-B cell stage of immature B cell differentiation and undergo rearrangement of heavy chain V, D, and J gene segments." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "pre-B lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002330 name: pre-B cell receptor expression namespace: biological_process def: "The process leading up to expression of the pre-B cell receptor on the surface of pre-B cells, including expression of the surrogate light chain, association of the surrogate light chain with heavy chain, and expression of the complete pre-B cell receptor on the cell surface." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002331 name: pre-B cell allelic exclusion namespace: biological_process def: "Expression of a single heavy chain allele during pre-B cell differentiation." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "pre-B lymphocyte allelic exclusion" EXACT [] is_a: GO:0002329 ! pre-B cell differentiation [Term] id: GO:0002332 name: transitional stage B cell differentiation namespace: biological_process def: "The process whereby immature B cells from the bone marrow become mature B cells in the spleen. Transitional stage B cells are subdivided into transitional one (T1) and transitional two (T2) stages and are short-lived and functionally incompetent." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "transitional stage B lymphocyte differentiation" EXACT [] synonym: "transitional stage B-cell differentiation" EXACT [] synonym: "transitional stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002327 ! immature B cell differentiation [Term] id: GO:0002333 name: transitional one stage B cell differentiation namespace: biological_process def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T1 stage B cells in the spleen. T1 stage B cells do not express either CD23 or CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "T1 stage B cell differentiation" EXACT [] synonym: "transitional one stage B lymphocyte differentiation" EXACT [] synonym: "transitional one stage B-cell differentiation" EXACT [] synonym: "transitional one stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002334 name: transitional two stage B cell differentiation namespace: biological_process def: "The process whereby immature B cells from the bone marrow acquire the specialized features of T2 stage B cells in the spleen. T2 stage B cells express CD23 but not CD21." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "T2 stage B cell differentiation" EXACT [] synonym: "transitional two stage B lymphocyte differentiation" EXACT [] synonym: "transitional two stage B-cell differentiation" EXACT [] synonym: "transitional two stage B-lymphocyte differentiation" EXACT [] is_a: GO:0002332 ! transitional stage B cell differentiation [Term] id: GO:0002335 name: mature B cell differentiation namespace: biological_process def: "The process whereby transitional stage B cells acquire the specialized features of mature B cells in the spleen." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "mature B lymphocyte differentiation" EXACT [] synonym: "mature B-cell differentiation" EXACT [] synonym: "mature B-lymphocyte differentiation" EXACT [] is_a: GO:0030183 ! B cell differentiation [Term] id: GO:0002336 name: B-1 B cell lineage commitment namespace: biological_process def: "The process by which an immature B cell becomes committed to become a B-1 B cell." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1 B lymphocyte lineage commitment" EXACT [] synonym: "B-1 B-cell lineage commitment" EXACT [] synonym: "B-1 B-lymphocyte lineage commitment" EXACT [] is_a: GO:0002326 ! B cell lineage commitment relationship: part_of GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002337 name: B-1a B cell differentiation namespace: biological_process def: "The process whereby B cells acquire the specialized features of B-1a B cells. B-1a B cells are B-1 cells that express CD5 and arise from fetal liver precursors." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1a B lymphocyte differentiation" EXACT [] synonym: "B-1a B-cell differentiation" EXACT [] synonym: "B-1a B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002338 name: B-1b B cell differentiation namespace: biological_process def: "The process whereby B cells acquire the specialized features of B-1b B cells. B-1b B cells are B-1 cells that do not express CD5." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B-1b B lymphocyte differentiation" EXACT [] synonym: "B-1b B-cell differentiation" EXACT [] synonym: "B-1b B-lymphocyte differentiation" EXACT [] is_a: GO:0001923 ! B-1 B cell differentiation [Term] id: GO:0002339 name: B cell selection namespace: biological_process def: "The process dependent upon B cell antigen receptor signaling in response to self or foreign antigen through which B cells are selected for survival." [GOC:jal] synonym: "B lymphocyte selection" EXACT [] synonym: "B-cell selection" EXACT [] synonym: "B-lymphocyte selection" EXACT [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0030183 ! B cell differentiation [Term] id: GO:0002340 name: central B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the bone marrow." [GOC:jal] synonym: "central B lymphocyte selection" EXACT [] synonym: "central B-cell selection" EXACT [] synonym: "central B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002341 name: central B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte anergy" EXACT [] synonym: "central B-cell anergy" EXACT [] synonym: "central B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002342 name: central B cell deletion namespace: biological_process def: "The deletion of B cells by apoptosis occurring as part of central tolerance induction and B cell selection." [GOC:add, GOC:jal] synonym: "central B lymphocyte deletion" EXACT [] synonym: "central B-cell deletion" EXACT [] synonym: "central B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002340 ! central B cell selection relationship: part_of GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002343 name: peripheral B cell selection namespace: biological_process def: "Any B cell selection process that occurs in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte selection" EXACT [] synonym: "peripheral B-cell selection" EXACT [] synonym: "peripheral B-lymphocyte selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002344 name: B cell affinity maturation namespace: biological_process def: "The process by which B cells produce antibodies with increased antigen affinity. This is accomplished by somatic hypermutation and selection for B cells which produce higher affinity antibodies to antigen." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "B lymphocyte affinity maturation" EXACT [] synonym: "B-cell affinity maturation" EXACT [] synonym: "B-lymphocyte affinity maturation" EXACT [] is_a: GO:0002343 ! peripheral B cell selection relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002345 name: peripheral B cell receptor editing namespace: biological_process def: "The process that takes place mainly in germinal center B cells in which a large number of mutations are generated in the heavy chain and light chain V-region genes and their immediately surrounding introns in order to increase antibody diversity and contribute to affinity maturation." [GOC:jal] synonym: "peripheral B lymphocyte receptor editing" EXACT [] synonym: "peripheral B-cell receptor editing" EXACT [] synonym: "peripheral B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002346 name: B cell positive selection namespace: biological_process def: "Any process by which B cells are selected to survive based on signaling through the B cell antigen receptor." [GOC:jal] synonym: "B lymphocyte positive selection" EXACT [] synonym: "B-cell positive selection" EXACT [] synonym: "B-lymphocyte positive selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002347 name: response to tumor cell namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0009607 ! response to biotic stimulus [Term] id: GO:0002348 name: central B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the bone marrow. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "central B lymphocyte positive selection" EXACT [] synonym: "central B-cell positive selection" EXACT [] synonym: "central B-lymphocyte positive selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002349 name: histamine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of histamine following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] synonym: "histamine production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002350 name: peripheral B cell positive selection namespace: biological_process def: "Any process leading to positive selection of B cells in the periphery. Positive selection is the process by which B or T cells are selected to survive based on signaling through their antigen receptors." [GOC:jal] synonym: "peripheral B lymphocyte positive selection" EXACT [] synonym: "peripheral B-cell positive selection" EXACT [] synonym: "peripheral B-lymphocyte positive selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002346 ! B cell positive selection [Term] id: GO:0002351 name: serotonin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of serotonin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] synonym: "serotonin production involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002352 name: B cell negative selection namespace: biological_process def: "Any process leading to negative selection in B cells. Mechanisms of negative selection include anergy and deletion." [GOC:jal] synonym: "B lymphocyte negative selection" EXACT [] synonym: "B-cell negative selection" EXACT [] synonym: "B-lymphocyte negative selection" EXACT [] is_a: GO:0002339 ! B cell selection [Term] id: GO:0002353 name: plasma kallikrein-kinin cascade namespace: biological_process def: "A series of reactions that takes place outside the cell occurring in response to tissue damage and initiated within blood plasma by the action of activated Factor XII (Hageman Factor) on prekallikrein to convert it to plasma kallikrein, and the subsequent reaction of plasma kallikrein with high molecular weight kininogen. The ultimate product of the plasma kallikrein-kinin cascade is bradykinin, an agent known to induce smooth muscle contraction, vasoconstriction, and increased vascular permeability." [GOC:add, ISBN:0721601871, PMID:11842287, PMID:14501145] is_a: GO:0002254 ! kinin cascade [Term] id: GO:0002354 name: central B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the bone marrow." [GOC:jal] synonym: "central B lymphocyte negative selection" EXACT [] synonym: "central B-cell negative selection" EXACT [] synonym: "central B-lymphocyte negative selection" EXACT [] is_a: GO:0002340 ! central B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002355 name: detection of tumor cell namespace: biological_process def: "The series of events in which a stimulus from a tumor cell is received and converted into a molecular signal." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0009595 ! detection of biotic stimulus [Term] id: GO:0002356 name: peripheral B cell negative selection namespace: biological_process def: "Any process leading to negative selection of B cells in the periphery." [GOC:jal] synonym: "peripheral B lymphocyte negative selection" EXACT [] synonym: "peripheral B-cell negative selection" EXACT [] synonym: "peripheral B-lymphocyte negative selection" EXACT [] is_a: GO:0002343 ! peripheral B cell selection is_a: GO:0002352 ! B cell negative selection [Term] id: GO:0002357 name: defense response to tumor cell namespace: biological_process def: "Reactions triggered in response to the presence of a tumor cell that act to protect the cell or organism." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006952 ! defense response [Term] id: GO:0002358 name: B cell homeostatic proliferation namespace: biological_process def: "The non-specific expansion of B cell populations within a whole or part of an organism to reach to a total number of B cells which will then remain stable over time in the absence of an external stimulus." [GOC:jal] synonym: "B lymphocyte homeostatic proliferation" EXACT [] synonym: "B-cell homeostatic proliferation" EXACT [] synonym: "B-lymphocyte homeostatic proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002359 name: B-1 B cell proliferation namespace: biological_process def: "The expansion of a B-1 B cell by cell division. Follows B cell activation." [GOC:jal] synonym: "B-1 B lymphocyte proliferation" EXACT [] synonym: "B-1 B-cell proliferation" EXACT [] synonym: "B-1 B-lymphocyte proliferation" EXACT [] is_a: GO:0042100 ! B cell proliferation [Term] id: GO:0002360 name: T cell lineage commitment namespace: biological_process def: "The process by which a lymphoid progenitor cell becomes committed to becoming any type of T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte lineage commitment" EXACT [] synonym: "T-cell lineage commitment" EXACT [] synonym: "T-lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002361 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell differentiation" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte differentiation" EXACT [] is_a: GO:0043367 ! CD4-positive, alpha beta T cell differentiation is_a: GO:0045066 ! regulatory T cell differentiation [Term] id: GO:0002362 name: CD4-positive, CD25-positive, alpha-beta regulatory T cell lineage commitment namespace: biological_process def: "The process by which a CD4-positive, alpha-beta T cell becomes committed to becoming a CD4-positive, CD25-positive, alpha-beta regulatory T cell." [GOC:add, PMID:15207821] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T lymphocyte lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-cell lineage commitment" EXACT [] synonym: "CD4-positive, CD25-positive, alpha-beta regulatory T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0002361 ! CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation [Term] id: GO:0002363 name: alpha-beta T cell lineage commitment namespace: biological_process def: "The process by which a pro-T cell becomes committed to becoming an alpha-beta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "alpha-beta T lymphocyte lineage commitment" EXACT [] synonym: "alpha-beta T-cell lineage commitment" EXACT [] synonym: "alpha-beta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0046632 ! alpha-beta T cell differentiation [Term] id: GO:0002364 name: NK T cell lineage commitment namespace: biological_process def: "The process by which a pro-T cell becomes committed to becoming an NK T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "natural killer T lymphocyte lineage commitment" EXACT [] synonym: "natural killer T-cell lineage commitment" EXACT [] synonym: "natural killer T-lymphocyte lineage commitment" EXACT [] synonym: "NK T lymphocyte lineage commitment" EXACT [] synonym: "NK T-cell lineage commitment" EXACT [] synonym: "NK T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0001865 ! NK T cell differentiation [Term] id: GO:0002365 name: gamma-delta T cell lineage commitment namespace: biological_process def: "The process by which a pro-T cell becomes committed to becoming a gamma-delta T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "gamma-delta T lymphocyte lineage commitment" EXACT [] synonym: "gamma-delta T-cell lineage commitment" EXACT [] synonym: "gamma-delta T-lymphocyte lineage commitment" EXACT [] is_a: GO:0002360 ! T cell lineage commitment relationship: part_of GO:0042492 ! gamma-delta T cell differentiation [Term] id: GO:0002366 name: leukocyte activation involved in immune response namespace: biological_process def: "A change in morphology and behavior of a leukocyte resulting from exposure to a specific antigen, mitogen, cytokine, cellular ligand, or soluble factor, leading to the initiation or perpetuation of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune cell activation during immune response" RELATED [] synonym: "leucocyte activation during immune response" RELATED [] synonym: "leukocyte activation during immune response" RELATED [GOC:tb] is_a: GO:0002263 ! cell activation involved in immune response is_a: GO:0045321 ! leukocyte activation [Term] id: GO:0002367 name: cytokine production involved in immune response namespace: biological_process def: "The appearance of a cytokine due to biosynthesis or secretion following a cellular stimulus contributing to an immune response, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. Note that this term is intended for use when a gene product is seen to cause apparent increases in intracellular or extracellular cytokine levels, without specific regard as to whether the increase is due to increased biosynthesis, increased secretion of preexisting cytokine molecules, or increased conversion from precursor molecules. synonym: "cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001816 ! cytokine production is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002368 name: B cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a B cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte cytokine production" EXACT [] synonym: "B-cell cytokine production" EXACT [] synonym: "B-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002369 name: T cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte cytokine production" EXACT [] synonym: "T-cell cytokine production" EXACT [] synonym: "T-lymphocyte cytokine production" EXACT [] is_a: GO:0002367 ! cytokine production involved in immune response is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002370 name: natural killer cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a natural killer cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "NK cell cytokine production" EXACT [] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002371 name: dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002372 name: myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a myeloid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002371 ! dendritic cell cytokine production is_a: GO:0061082 ! myeloid leukocyte cytokine production [Term] id: GO:0002373 name: plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that contributes to cytokine production by a plasmacytoid dendritic cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002374 name: cytokine secretion involved in immune response namespace: biological_process def: "The regulated release of cytokines from a cell or group of cells that contributes to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0050663 ! cytokine secretion relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002375 name: cytokine biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cytokine that contributes to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0042089 ! cytokine biosynthetic process relationship: part_of GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002376 name: immune system process namespace: biological_process def: "Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: Note that this term is a direct child of 'biological_process ; GO:0008150' because some immune system processes are types of cellular process (GO:0009987), whereas others are types of multicellular organism process (GO:0032501). This term was added by GO_REF:0000022. subset: goslim_pir xref: Wikipedia:Immune_system is_a: GO:0008150 ! biological_process [Term] id: GO:0002377 name: immunoglobulin production namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody production" EXACT [] is_a: GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002378 name: immunoglobulin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody biosynthesis" EXACT [] synonym: "antibody biosynthetic process" EXACT [] is_a: GO:0009059 ! macromolecule biosynthetic process relationship: part_of GO:0002377 ! immunoglobulin production [Term] id: GO:0002379 name: immunoglobulin biosynthetic process involved in immune response namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of immunoglobulin contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody biosynthesis during immune response" RELATED [] synonym: "antibody biosynthetic process during immune response" RELATED [] synonym: "immunoglobulin biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002378 ! immunoglobulin biosynthetic process relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002380 name: immunoglobulin secretion involved in immune response namespace: biological_process def: "The regulated release of immunoglobulins from a B cell or plasma cell contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:9185563] synonym: "antibody secretion during immune response" RELATED [] synonym: "immunoglobulin secretion during immune response" RELATED [goc:dph] is_a: GO:0048305 ! immunoglobulin secretion relationship: part_of GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response [Term] id: GO:0002381 name: immunoglobulin production involved in immunoglobulin mediated immune response namespace: biological_process def: "The appearance of immunoglobulin due to biosynthesis or secretion following a cellular stimulus during an immune response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antibody production during immune response" RELATED [] synonym: "immunoglobulin production during immune response" RELATED [GOC:dph] synonym: "immunoglobulin production involved in immune response" RELATED [GOC:dph] is_a: GO:0002377 ! immunoglobulin production relationship: part_of GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002382 name: regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002256 ! regulation of kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002383 name: immune response in brain or nervous system namespace: biological_process def: "An immune response taking place in the brain or nervous system." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002384 name: hepatic immune response namespace: biological_process def: "An immune response taking place in the liver." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002385 name: mucosal immune response namespace: biological_process def: "An immune response taking place in mucosal tissues, including those of the intestinal tract, nasal and upper respiratory tract, and genital tract." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002251 ! organ or tissue specific immune response [Term] id: GO:0002386 name: immune response in mucosal-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the mucosal-associated lymphoid tissue (MALT). Mucosal-associated lymphoid tissue is typically found as nodules associated with mucosal epithelia with distinct internal structures including B- and T-zones for the activation of lymphocytes." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in MALT" EXACT [] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002387 name: immune response in gut-associated lymphoid tissue namespace: biological_process def: "Immune response taking place in the gut-associated lymphoid tissue (GALT). GALT includes Peyer's patches, appendix, and solitary lymph nodules." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in GALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002388 name: immune response in Peyer's patch namespace: biological_process def: "Immune response taking place in the Peyer's patch, nodular lymphoid structures on the serosal surface of the small intestine." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue [Term] id: GO:0002389 name: tolerance induction in Peyer's patch namespace: biological_process def: "Tolerance induction taking place in the Peyer's patches." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002388 ! immune response in Peyer's patch is_a: GO:0002394 ! tolerance induction in gut-associated lymphoid tissue [Term] id: GO:0002390 name: platelet activating factor production namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001816 ! cytokine production [Term] id: GO:0002391 name: platelet activating factor production involved in inflammatory response namespace: biological_process def: "The synthesis or release of platelet activating factor following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "platelet activating factor production involved in acute inflammatory response" BROAD [] is_a: GO:0002390 ! platelet activating factor production is_a: GO:0002534 ! cytokine production involved in inflammatory response [Term] id: GO:0002392 name: platelet activating factor secretion namespace: biological_process def: "The regulated release of platelet activating factor by a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0050663 ! cytokine secretion [Term] id: GO:0002393 name: production of lysosomal enzymes involved in inflammatory response namespace: biological_process def: "The synthesis or release of lysosomal enzymes following a stimulus as part of a inflammatory response, resulting in an increase in intracellular or extracellular levels." [GOC:add] synonym: "production of lysosomal enzymes involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002394 name: tolerance induction in gut-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the gut-associated lymphoid tissue (GALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "oral tolerance" RELATED [] synonym: "tolerance induction in GALT" EXACT [] is_a: GO:0002387 ! immune response in gut-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002395 name: immune response in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "An immune response taking place in the nasopharyngeal-associated lymphoid tissue (NALT). NALT includes the tonsils and adenoids." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "immune response in NALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002396 name: MHC protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591, PMID:15928678] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0002397 name: MHC class I protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002398 name: MHC class Ib protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002399 name: MHC class II protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002396 ! MHC protein complex assembly [Term] id: GO:0002400 name: tolerance induction in nasopharyngeal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the nasopharyngeal-associated lymphoid tissue (NALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "nasal tolerance" RELATED [] synonym: "tolerance induction in NALT" EXACT [] is_a: GO:0002395 ! immune response in nasopharyngeal-associated lymphoid tissue is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue [Term] id: GO:0002401 name: tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT)." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "tolerance induction in MALT" EXACT [] is_a: GO:0002386 ! immune response in mucosal-associated lymphoid tissue is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002402 name: B cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002403 name: T cell tolerance induction in mucosal-associated lymphoid tissue namespace: biological_process def: "Tolerance induction taking place in the mucosal-associated lymphoid tissue (MALT) mediated by T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] synonym: "T cell tolerance induction in MALT" EXACT [] is_a: GO:0002401 ! tolerance induction in mucosal-associated lymphoid tissue is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002404 name: antigen sampling in mucosal-associated lymphoid tissue namespace: biological_process def: "The process initiating the mucosal immune response which entails the apical-to-basolateral delivery of soluble and particulate antigens to underlying mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:12843411, PMID:15681746] synonym: "antigen sampling in MALT" EXACT [] synonym: "antigen transport in MALT" RELATED [] synonym: "antigen transport in mucosal-associated lymphoid tissue" RELATED [] is_a: GO:0002376 ! immune system process relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002405 name: antigen sampling by dendritic cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen sampling carried out by dendritic cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763, PMID:15681746] synonym: "antigen sampling by dendritic cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue relationship: part_of GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002406 name: antigen sampling by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen samples carried out by M cells in the mucosal-associated lymphoid tissue." [GOC:jal, PMID:11896763] synonym: "antigen sampling by M cells in MALT" EXACT [] is_a: GO:0002404 ! antigen sampling in mucosal-associated lymphoid tissue [Term] id: GO:0002407 name: dendritic cell chemotaxis namespace: biological_process def: "The movement of a dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002408 name: myeloid dendritic cell chemotaxis namespace: biological_process def: "The movement of a myeloid dendritic cell in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15814331, PMID:16056255] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002409 name: Langerhans cell chemotaxis namespace: biological_process def: "The movement of a Langerhans cell in response to an external stimulus." [GOC:add, PMID:16056255, PMID:16387601] is_a: GO:0002408 ! myeloid dendritic cell chemotaxis [Term] id: GO:0002410 name: plasmacytoid dendritic cell chemotaxis namespace: biological_process def: "The movement of a plasmacytoid dendritic cell in response to an external stimulus." [GOC:add, PMID:15159375, PMID:15814331] is_a: GO:0002407 ! dendritic cell chemotaxis [Term] id: GO:0002411 name: T cell tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction dependent on T cells which leads to immunological tolerance of a tumor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002413 ! tolerance induction to tumor cell is_a: GO:0002424 ! T cell mediated immune response to tumor cell is_a: GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002412 name: antigen transcytosis by M cells in mucosal-associated lymphoid tissue namespace: biological_process def: "The process of antigen transcytosis carried out by M cells in the mucosal-associated lymphoid tissue (MALT). Transcytosis is the process of the directed movement of endocytosed material through the cell and its exocytosis from the plasma membrane at the opposite side. M cells are specialized epithelia cells with a microfold structure that are adept at moving antigens from the gut lumen to antigen presenting cells in the MALT." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:12843411] synonym: "antigen transcytosis by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in MALT" EXACT [] synonym: "antigen transport by M cells in mucosal-associated lymphoid tissue" EXACT [] is_a: GO:0045056 ! transcytosis relationship: part_of GO:0002406 ! antigen sampling by M cells in mucosal-associated lymphoid tissue [Term] id: GO:0002413 name: tolerance induction to tumor cell namespace: biological_process def: "A process of tolerance induction which leads to immunological tolerance of a tumor." [GOC:add] is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002414 name: immunoglobulin transcytosis in epithelial cells namespace: biological_process def: "The process of transporting immunoglobulin, via transcytosis, from one side of an epithelial cell to the other." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] is_a: GO:0045056 ! transcytosis [Term] id: GO:0002415 name: immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor namespace: biological_process def: "The process of transporting polymeric IgA and polymeric IgM immunoglobulin, via transcytosis mediated by the polymeric immunoglobulin receptor (pIgR), from the basolateral surface to apical surface of an epithelial cell. At the apical surface the immunoglobulin binding portion of the pIgRis cleaved and remains bound to the transported immunoglobulin as secretory component (SC). The same process is used for the transport and excretion of IgA immune complexes to the luminal surface of the mucosa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X, PMID:16048543] synonym: "antibody transcytosis mediated by pIgR" EXACT [] synonym: "immunoglobulin transcytosis mediated by pIgR" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells relationship: part_of GO:0002386 ! immune response in mucosal-associated lymphoid tissue [Term] id: GO:0002416 name: IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor namespace: biological_process def: "The process of transporting IgG immunoglobulin, via transcytosis using the FcRn (also known as the neonatal Fc receptor; gene name FCGRT), from apical surface of an epithelial cell to the basolateral surface or vice versa depending on the location. This process is used for uptake of IgG from the milk in the gut in rodents, for transplacental transport of IgG from mother to embryo in humans, and for maintenance of a steady-state distribution of IgG across epithelial boundaries in general in adult mammals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", ISBN:081533642X] synonym: "IgG antibody transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor" EXACT [] synonym: "IgG immunoglobulin transcytosis in epithelial cells mediated by neonatal immunoglobulin receptor" EXACT [] is_a: GO:0002414 ! immunoglobulin transcytosis in epithelial cells [Term] id: GO:0002417 name: B cell antigen processing and presentation mediated by B cell receptor uptake of antigen namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen bound to the B cell receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "B lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-cell antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] synonym: "B-lymphocyte antigen processing and presentation mediated by B cell receptor uptake of antigen" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002751 ! antigen processing and presentation following receptor mediated endocytosis [Term] id: GO:0002418 name: immune response to tumor cell namespace: biological_process def: "An immune system process that functions in the response of an organism to a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002347 ! response to tumor cell is_a: GO:0006955 ! immune response [Term] id: GO:0002419 name: T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a T cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "T lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "T-lymphocyte mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001913 ! T cell mediated cytotoxicity is_a: GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002420 name: natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "The directed killing of a tumor cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that either or both mechanisms mentioned in the definition may be used in this process. Note that both granule release and the engagement of death receptors on target cells result in induction of apoptosis in the target cell. synonym: "NK cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002423 ! natural killer cell mediated immune response to tumor cell is_a: GO:0042267 ! natural killer cell mediated cytotoxicity [Term] id: GO:0002421 name: B cell antigen processing and presentation following pinocytosis namespace: biological_process def: "B cell antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, PMID:7543530] synonym: "B lymphocyte antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-cell antigen processing and presentation following pinocytosis" EXACT [] synonym: "B-lymphocyte antigen processing and presentation following pinocytosis" EXACT [] is_a: GO:0002450 ! B cell antigen processing and presentation is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002422 name: immune response in urogenital tract namespace: biological_process def: "An immune response taking place in the urogenital tract. The urogenital tract." [GOC:jal] is_a: GO:0002385 ! mucosal immune response [Term] id: GO:0002423 name: natural killer cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a natural killer cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] is_a: GO:0002228 ! natural killer cell mediated immunity is_a: GO:0002418 ! immune response to tumor cell [Term] id: GO:0002424 name: T cell mediated immune response to tumor cell namespace: biological_process def: "An immune response mediated by a T cell triggered in response to the presence of a tumor cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16730260] comment: Note that this term includes tolerogenic responses to tumor cells mediated by responding T cells. is_a: GO:0002418 ! immune response to tumor cell is_a: GO:0002456 ! T cell mediated immunity [Term] id: GO:0002425 name: tolerance induction in urogenital tract namespace: biological_process def: "Tolerance induction taking place in the urogenital tract." [GOC:jal] is_a: GO:0002422 ! immune response in urogenital tract is_a: GO:0002427 ! mucosal tolerance induction [Term] id: GO:0002426 name: immunoglobulin production in mucosal tissue namespace: biological_process def: "The synthesis and release of immunoglobulin in the mucosal tissue." [GOC:jal] synonym: "antibody production in mucosal tissue " EXACT [] is_a: GO:0002381 ! immunoglobulin production involved in immunoglobulin mediated immune response relationship: part_of GO:0002385 ! mucosal immune response [Term] id: GO:0002427 name: mucosal tolerance induction namespace: biological_process def: "Tolerance induction taking place in the mucosal tissues." [GOC:jal] is_a: GO:0002385 ! mucosal immune response is_a: GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002428 name: antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "The process by which an antigen-presenting cell expresses peptide antigen in association with an MHC class Ib protein complex on its cell surface. The peptide antigen may originate from an endogenous or exogenous protein. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E family." [GOC:add, PMID:15928678] synonym: "peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002475 ! antigen processing and presentation via MHC class Ib is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002429 name: immune response-activating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a cell capable of activating or perpetuating an immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "activation of immune response by cell surface receptor signaling pathway" EXACT [] synonym: "immune response-activating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002757 ! immune response-activating signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002430 name: complement receptor mediated signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a component of the complement pathway binding to a complement receptor. Such components include both whole complement proteins and fragments of complement proteins generated through the activity of the complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "complement receptor mediated signalling pathway" EXACT [] synonym: "immune response-regulating cell surface receptor signalling pathway" BROAD [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002431 name: Fc receptor mediated stimulatory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of activating or perpetuating an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "Fc receptor mediated stimulatory signalling pathway" EXACT [] synonym: "Fc-receptor mediated stimulatory signaling pathway" EXACT [] is_a: GO:0002429 ! immune response-activating cell surface receptor signaling pathway [Term] id: GO:0002432 name: granuloma formation namespace: biological_process def: "The formation of nodular inflammatory lesions, usually small or granular, firm, persistent, well-structured, and containing compactly grouped T lymphocytes and modified phagocytes such as epithelioid cells, giant cells, and other macrophages. Granuloma formation represents a chronic inflammatory response initiated by various infectious and noninfectious agents. The center of a granuloma consists of fused macrophages, which can become necrotic." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0721601464, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process relationship: part_of GO:0002544 ! chronic inflammatory response [Term] id: GO:0002433 name: phagocytosis triggered by activation of immune response cell surface activating receptor namespace: biological_process def: "Phagocytosis occurring as the result of a ligand binding an immune response cell surface activating receptor." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process is_a: GO:0006909 ! phagocytosis [Term] id: GO:0002434 name: immune complex clearance namespace: biological_process def: "A process directed at removing immune complexes from the body. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:068340007X "Stedman's Medical Dictionary"] comment: This term was added by GO_REF:0000022. is_a: GO:0002252 ! immune effector process [Term] id: GO:0002435 name: immune complex clearance by erythrocytes namespace: biological_process def: "The process of immune complex clearance by erythrocytes." [GOC:add, PMID:11414352] synonym: "immune complex clearance by RBCs" EXACT [CL:0000232] synonym: "immune complex clearance by red blood cells" EXACT [CL:0000232] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002436 name: immune complex clearance by monocytes and macrophages namespace: biological_process def: "The process of immune complex clearance by monocytes or macrophages." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002434 ! immune complex clearance [Term] id: GO:0002437 name: inflammatory response to antigenic stimulus namespace: biological_process def: "An inflammatory response to an antigenic stimulus, which can be include any number of T cell or B cell epitopes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0006954 ! inflammatory response is_a: GO:0006955 ! immune response [Term] id: GO:0002438 name: acute inflammatory response to antigenic stimulus namespace: biological_process def: "An acute inflammatory response to an antigenic stimulus. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002439 name: chronic inflammatory response to antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to an antigenic stimulus. A chronic inflammatory response persists indefinitely during days, weeks, or months in the life of an individual." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002437 ! inflammatory response to antigenic stimulus is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002440 name: production of molecular mediator of immune response namespace: biological_process def: "The synthesis or release of any molecular mediator of the immune response following an immunological stimulus, resulting in an increase in its intracellular or extracellular levels." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "production of cellular mediator of immune response" RELATED [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002441 name: histamine secretion involved in inflammatory response namespace: biological_process def: "The regulated release of histamine by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "histamine secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001821 ! histamine secretion is_a: GO:0046879 ! hormone secretion relationship: part_of GO:0002349 ! histamine production involved in inflammatory response [Term] id: GO:0002442 name: serotonin secretion involved in inflammatory response namespace: biological_process def: "The regulated release of serotonin by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "serotonin secretion involved in acute inflammatory response" BROAD [] is_a: GO:0001820 ! serotonin secretion relationship: part_of GO:0002351 ! serotonin production involved in inflammatory response [Term] id: GO:0002443 name: leukocyte mediated immunity namespace: biological_process alt_id: GO:0019723 alt_id: GO:0042087 def: "Any process involved in the carrying out of an immune response by a leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immune response" RELATED [] synonym: "cellular immune response" RELATED [] synonym: "immune cell effector process" EXACT [] synonym: "immune cell mediated immunity" EXACT [] synonym: "leucocyte immune effector process" EXACT [] synonym: "leucocyte mediated immunity" EXACT [] synonym: "leukocyte immune effector process" EXACT [] is_a: GO:0002252 ! immune effector process [Term] id: GO:0002444 name: myeloid leukocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a myeloid leukocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "myeloid leucocyte immune effector process" EXACT [] synonym: "myeloid leucocyte mediated immunity" EXACT [] synonym: "myeloid leukocyte immune effector process" EXACT [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002445 name: type II hypersensitivity namespace: biological_process def: "An inflammatory response resulting in cell death or dysfunction mediated by activation of the classical complement pathway or induction of effector cell phagocytosis, cytolysis mechanisms via complement or Fc receptors following the binding of antibodies to cell surface antigens on a target cell, or mediated by the direct binding of antibody to cellular receptors." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Type_II_hypersensitivity is_a: GO:0002444 ! myeloid leukocyte mediated immunity is_a: GO:0002524 ! hypersensitivity is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002446 name: neutrophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a neutrophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002447 name: eosinophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by an eosinophil." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002448 name: mast cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a mast cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002449 name: lymphocyte mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a lymphocyte." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] is_a: GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002450 name: B cell antigen processing and presentation namespace: biological_process def: "The process by which a B cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "B lymphocyte antigen processing and presentation" EXACT [] synonym: "B-cell antigen processing and presentation" EXACT [] synonym: "B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0019724 ! B cell mediated immunity [Term] id: GO:0002451 name: peripheral B cell tolerance induction namespace: biological_process def: "Tolerance induction of mature B cells in the peripheral lymphoid tissues: the blood, lymph nodes, spleen, and mucosal-associated lymphoid tissue." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte tolerance induction" EXACT [] synonym: "peripheral B-cell tolerance induction" EXACT [] synonym: "peripheral B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002514 ! B cell tolerance induction is_a: GO:0019724 ! B cell mediated immunity [Term] id: GO:0002452 name: B cell receptor editing namespace: biological_process def: "The process of replacing receptors on B cells, in which RAG gene expression allows continued light-chain gene rearrangement and expression of a new light change which combines with the previous heavy chain to form a new receptor." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte receptor editing" EXACT [] synonym: "B-cell receptor editing" EXACT [] synonym: "B-lymphocyte receptor editing" EXACT [] is_a: GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002453 name: peripheral B cell anergy namespace: biological_process def: "Any process contributing to anergy, a state of functional inactivation that occurs as part of tolerance induction, in peripheral B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte anergy" EXACT [] synonym: "peripheral B-cell anergy" EXACT [] synonym: "peripheral B-lymphocyte anergy" EXACT [] is_a: GO:0002515 ! B cell anergy relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002454 name: peripheral B cell deletion namespace: biological_process def: "The deletion of B cells by apoptosis occurring as part of peripheral tolerance induction and B cell selection." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral B lymphocyte deletion" EXACT [] synonym: "peripheral B-cell deletion" EXACT [] synonym: "peripheral B-lymphocyte deletion" EXACT [] is_a: GO:0002516 ! B cell deletion relationship: part_of GO:0002451 ! peripheral B cell tolerance induction [Term] id: GO:0002455 name: humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "An immune response dependent upon secreted immunoglobulin. An example of this process is found in Mus musculus." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "circulating antibody mediated immune response" EXACT [] synonym: "circulating immunoglobulin mediated immune response" EXACT [] synonym: "humoral defence mechanism" RELATED [] synonym: "humoral immune response mediated by circulating antibody" EXACT [] is_a: GO:0006959 ! humoral immune response is_a: GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002456 name: T cell mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a T cell." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "cell-mediated immunity" BROAD [] synonym: "cellular immune response" BROAD [] synonym: "T lymphocyte mediated immunity" EXACT [] synonym: "T-cell mediated immunity" EXACT [] synonym: "T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002449 ! lymphocyte mediated immunity is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002457 name: T cell antigen processing and presentation namespace: biological_process def: "The process by which a T cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11417857, PMID:15120183] synonym: "T lymphocyte antigen processing and presentation" EXACT [] synonym: "T-cell antigen processing and presentation" EXACT [] synonym: "T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0019882 ! antigen processing and presentation relationship: part_of GO:0002456 ! T cell mediated immunity [Term] id: GO:0002458 name: peripheral T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the periphery, in this case, any location in the body other than the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "peripheral T lymphocyte tolerance induction" EXACT [] synonym: "peripheral T-cell tolerance induction" EXACT [] synonym: "peripheral T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002456 ! T cell mediated immunity is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002459 name: adaptive immune response based on somatic recombination of immune receptors built from leucine-rich repeat domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of variable lymphocyte receptors (VLR) incorporating leucine-rich repeat (LRR) domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Examples of this process are found in jawless fish, including the lampreys (Petromyzontidae) and hagfishes (Myxinidae)." [GOC:add, GOC:mtg_sensu, PMID:16373579] synonym: "adaptive immune response based on somatic recombination of variable lymphocyte receptors built from leucine-rich repeat domains" EXACT [] synonym: "adaptive immune response based on somatic recombination of VLR built from LRR domains" EXACT [] synonym: "adaptive immune response in jawless fish" EXACT [] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002460 name: adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "An immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process that includes somatic recombination of germline gene segments encoding immunoglobulin superfamily domains, and allowing for enhanced responses upon subsequent exposures to the same antigen (immunological memory). Recombined receptors for antigen encoded by immunoglobulin superfamily domains include T cell receptors and immunoglobulins (antibodies). An example of this is the adaptive immune response found in Mus musculus." [GOC:add, GOC:mtg_sensu, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002250 ! adaptive immune response [Term] id: GO:0002461 name: tolerance induction dependent upon immune response namespace: biological_process def: "Tolerance induction dependent upon an immune response, typically a response by a mature T or B cell in the periphery resulting tolerance towards an antigen via induction of anergy, cellular deletion, or regulatory T cell activation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. synonym: "immune response-dependent tolerance induction" EXACT [] is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002462 name: tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction in response to nonself antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002463 name: central tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the central lymphoid organs." [GOC:jal, PMID:12547504] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002508 ! central tolerance induction [Term] id: GO:0002464 name: peripheral tolerance induction to nonself antigen namespace: biological_process def: "Tolerance induction to nonself antigens in the periphery." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002462 ! tolerance induction to nonself antigen is_a: GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002465 name: peripheral tolerance induction namespace: biological_process def: "Tolerance induction in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002466 name: peripheral tolerance induction to self antigen namespace: biological_process def: "Tolerance induction to self antigens in the peripheral lymphoid tissues: blood, lymph nodes, spleen, and mucosal-associated lymphoid tissues." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002465 ! peripheral tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002467 name: germinal center formation namespace: biological_process def: "The process by which germinal centers form. A germinal center is a specialized microenvironment formed when activated B cells enter lymphoid follicles. Germinal centers are the foci for B cell proliferation and somatic hypermutation." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:081533642X] comment: This term was added by GO_REF:0000022. is_a: GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002468 name: dendritic cell antigen processing and presentation namespace: biological_process def: "The process by which a dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002469 name: myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "The process by which a myeloid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002470 name: plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "The process by which a plasmacytoid dendritic cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002471 name: monocyte antigen processing and presentation namespace: biological_process def: "The process by which a monocyte expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, PMID:11200054] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002472 name: macrophage antigen processing and presentation namespace: biological_process def: "The process by which a macrophage expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002473 name: non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "The process by which a non-professional antigen presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC protein complex. Non-professional antigen presenting cells include all cell types but dendritic cells, B cells, T cells, monocytes, macrophages, and neutrophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002474 name: antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002475 name: antigen processing and presentation via MHC class Ib namespace: biological_process def: "The process by which an antigen-presenting cell expresses antigen (peptide or lipid) on its cell surface in association with an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002476 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen [Term] id: GO:0002477 name: antigen processing and presentation of exogenous peptide antigen via MHC class Ib namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib is_a: GO:0002478 ! antigen processing and presentation of exogenous peptide antigen [Term] id: GO:0002478 name: antigen processing and presentation of exogenous peptide antigen namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "exogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019884 ! antigen processing and presentation of exogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002479 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class I molecule. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002480 name: antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class I here refers to classical class I molecules." [GOC:add, PMID:15224093, PMID:15771591, PMID:16181335] synonym: "cross presentation" BROAD [] synonym: "cross-presentation" BROAD [] synonym: "exogenous peptide antigen processing and presentation via MHC class I, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class I" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0042590 ! antigen processing and presentation of exogenous peptide antigen via MHC class I [Term] id: GO:0002481 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-dependent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002482 name: antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-independent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of exogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger exogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "exogenous peptide antigen processing and presentation via MHC class Ib, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of exogenous peptide antigen via MHC class Ib" EXACT [] synonym: "TAP-independent exogenous peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002477 ! antigen processing and presentation of exogenous peptide antigen via MHC class Ib [Term] id: GO:0002483 name: antigen processing and presentation of endogenous peptide antigen namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "endogenous peptide antigen processing and presentation" EXACT [] is_a: GO:0019883 ! antigen processing and presentation of endogenous antigen is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002484 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002485 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-dependent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following TAP-dependent transport from the cytosol. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002486 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex following intracellular transport via a TAP-independent ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in the ER following transport from the cytosol via a TAP-independent pathway. Class I here refers to classical class I molecules." [GOC:add, PMID:14647477, PMID:15771591] synonym: "endogenous peptide antigen processing and presentation via MHC class I via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class I via ER pathway" EXACT [] is_a: GO:0002484 ! antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway [Term] id: GO:0002487 name: antigen processing and presentation of endogenous peptide antigen via MHC class I via endolysosomal pathway namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class I protein complex. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class I molecule in an endolysosome. Class I here refers to classical class I molecules." [GOC:add, PMID:10631943] synonym: "endogenous peptide antigen processing and presentation via MHC class I via endolysosomal pathway" EXACT [] is_a: GO:0019885 ! antigen processing and presentation of endogenous peptide antigen via MHC class I [Term] id: GO:0002488 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via an ER pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and becomes associated with the MHC class Ib molecule in the ER. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002476 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib [Term] id: GO:0002489 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-dependent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a TAP (transporter associated with antigen processing) pathway. The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell and is dependent on TAP transport from the cytosol to ER for association with the MHC class Ib molecule. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-dependent" EXACT [] synonym: "TAP-dependent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-dependent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002490 name: antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway, TAP-independent namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class Ib protein complex following intracellular transport via a pathway not requiring TAP (transporter associated with antigen processing). The peptide is typically a fragment of a larger endogenous protein which has been degraded within the cell. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] synonym: "endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway, TAP-independent" EXACT [] synonym: "TAP-independent antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway" EXACT [] synonym: "TAP-independent endogenous peptide antigen processing and presentation via MHC class Ib via ER pathway" EXACT [] is_a: GO:0002488 ! antigen processing and presentation of endogenous peptide antigen via MHC class Ib via ER pathway [Term] id: GO:0002491 name: antigen processing and presentation of endogenous peptide antigen via MHC class II namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen of endogenous origin on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, PMID:15531770, PMID:16181338] synonym: "endogenous peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002483 ! antigen processing and presentation of endogenous peptide antigen is_a: GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002492 name: peptide antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a peptide antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the HLA-E gene family." [GOC:add, PMID:15928678] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002493 name: lipid antigen assembly with MHC class Ib protein complex namespace: biological_process def: "The binding of a lipid antigen to the antigen binding groove of an MHC class Ib protein complex. Class Ib here refers to non-classical class I molecules, such as those of the CD1 gene family." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0065005 ! protein-lipid complex assembly relationship: part_of GO:0002398 ! MHC class Ib protein complex assembly relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002494 name: lipid antigen transport namespace: biological_process def: "The directed movement of a lipid antigen into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:add, PMID:15928678, PMID:15928680] is_a: GO:0006869 ! lipid transport relationship: part_of GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002495 name: antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "The process by which an antigen-presenting cell expresses a peptide antigen on its cell surface in association with an MHC class II protein complex. The peptide antigen is typically, but not always, processed from a whole protein." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591] synonym: "peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002496 name: proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002497 name: proteasomal proteolysis associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by the proteasome complex contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0002498 name: proteolysis within endoplasmic reticulum associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by ER resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15224092, PMID:15771591] synonym: "endoplasmic reticulum proteolysis associated with antigen processing and presentation" EXACT [] synonym: "ER proteolysis associated with antigen processing and presentation" EXACT [] synonym: "proteolysis within ER associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002499 name: proteolysis within endosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by endosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "endosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002500 name: proteolysis within lysosome associated with antigen processing and presentation namespace: biological_process def: "The hydrolysis of a peptide bond or bonds within a protein by lysosomal resident proteases contributing to antigen processing and presentation." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] synonym: "lysosomal proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002496 ! proteolysis associated with antigen processing and presentation is_a: GO:0007039 ! vacuolar protein catabolic process [Term] id: GO:0002501 name: peptide antigen assembly with MHC protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0002396 ! MHC protein complex assembly relationship: part_of GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002502 name: peptide antigen assembly with MHC class I protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class I protein complex. Class I here refers to classical class I molecules." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002397 ! MHC class I protein complex assembly relationship: part_of GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002503 name: peptide antigen assembly with MHC class II protein complex namespace: biological_process def: "The binding of a peptide to the antigen binding groove of an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771591] is_a: GO:0002501 ! peptide antigen assembly with MHC protein complex relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002504 name: antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "The process by which an antigen-presenting cell expresses antigen (peptide or polysaccharide) on its cell surface in association with an MHC class II protein complex." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15531770, PMID:15771591, PMID:16153240] synonym: "peptide or polysaccharide antigen processing and presentation of via MHC class II" EXACT [] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002505 name: antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "The process by which an antigen-presenting cell expresses a polysaccharide antigen on its cell surface in association with an MHC class II protein complex." [GOC:add, PMID:16153240] synonym: "polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002506 name: polysaccharide assembly with MHC class II protein complex namespace: biological_process def: "The binding of a polysaccharide to the antigen binding groove of an MHC class II protein complex." [GOC:add, PMID:16153240] is_a: GO:0065006 ! protein-carbohydrate complex assembly relationship: part_of GO:0002399 ! MHC class II protein complex assembly relationship: part_of GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002507 name: tolerance induction namespace: biological_process def: "A process that directly activates any of the steps required for tolerance, a physiologic state in which the immune system does not react destructively against the components of an organism that harbors it or against antigens that are introduced to it." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002376 ! immune system process [Term] id: GO:0002508 name: central tolerance induction namespace: biological_process def: "Tolerance induction in the central lymphoid organs: the thymus and bone marrow." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction relationship: part_of GO:0002520 ! immune system development [Term] id: GO:0002509 name: central tolerance induction to self antigen namespace: biological_process def: "Tolerance induction in the central lymphoid organs directed at self antigens." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002510 name: central B cell tolerance induction namespace: biological_process def: "Tolerance induction of B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte tolerance induction" EXACT [] synonym: "central B-cell tolerance induction" EXACT [] synonym: "central B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002511 name: central B cell receptor editing namespace: biological_process def: "Receptor editing occurring in B cells in the bone marrow." [GOC:jal, PMID:16460922] synonym: "central B lymphocyte receptor editing" EXACT [] synonym: "central B-cell receptor editing" EXACT [] synonym: "central B-lymphocyte receptor editing" EXACT [] is_a: GO:0002452 ! B cell receptor editing [Term] id: GO:0002512 name: central T cell tolerance induction namespace: biological_process def: "Tolerance induction of T cells in the thymus." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "central T lymphocyte tolerance induction" EXACT [] synonym: "central T-cell tolerance induction" EXACT [] synonym: "central T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002508 ! central tolerance induction is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002513 name: tolerance induction to self antigen namespace: biological_process def: "Tolerance induction directed at self antigens." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002514 name: B cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in B cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16460922] synonym: "B lymphocyte tolerance induction" EXACT [] synonym: "B-cell tolerance induction" EXACT [] synonym: "B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002515 name: B cell anergy namespace: biological_process def: "Any process contributing to anergy in B cells, a state of functional inactivation which is part of B cell tolerance induction." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte anergy" EXACT [] synonym: "B-cell anergy" EXACT [] synonym: "B-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002514 ! B cell tolerance induction [Term] id: GO:0002516 name: B cell deletion namespace: biological_process def: "The apoptotic death of B cells which is part of B cell tolerance induction." [GOC:add, GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "B lymphocyte deletion" EXACT [] synonym: "B-cell deletion" EXACT [] synonym: "B-lymphocyte deletion" EXACT [] is_a: GO:0001783 ! B cell apoptosis relationship: part_of GO:0002514 ! B cell tolerance induction [Term] id: GO:0002517 name: T cell tolerance induction namespace: biological_process def: "A process involving any mechanism for tolerance induction in T cells." [GOC:jal, ISBN:0781735149 "Fundamental Immunology", PMID:16551263] synonym: "T lymphocyte tolerance induction" EXACT [] synonym: "T-cell tolerance induction" EXACT [] synonym: "T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002518 name: lymphocyte chemotaxis across high endothelial venule namespace: biological_process def: "The movement of a lymphocyte to cross a high endothelial venule in response to an external stimulus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15122201] is_a: GO:0048247 ! lymphocyte chemotaxis [Term] id: GO:0002519 name: natural killer cell tolerance induction namespace: biological_process def: "Tolerance induction of natural killer cells." [GOC:jal, PMID:16546094] synonym: "NK cell tolerance induction" EXACT [] is_a: GO:0002507 ! tolerance induction [Term] id: GO:0002520 name: immune system development namespace: biological_process def: "The process whose specific outcome is the progression of an organismal system whose objective is to provide calibrated responses by an organism to a potential internal or invasive threat, over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process." [GOC:add, GOC:dph] is_a: GO:0002376 ! immune system process is_a: GO:0048731 ! system development [Term] id: GO:0002521 name: leukocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized hemopoietic precursor cell acquires the specialized features of a plasmacytoid dendritic cell or any cell of the myeloid leukocyte or lymphocyte lineages." [GOC:add, PMID:16551264] synonym: "immune cell differentiation" EXACT [] synonym: "leucocyte differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0030097 ! hemopoiesis [Term] id: GO:0002522 name: leukocyte migration involved in immune response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body as part of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during immune response" EXACT [] synonym: "immune cell trafficking during immune response" EXACT [] synonym: "leucocyte migration during immune response" EXACT [] synonym: "leucocyte trafficking during immune response" EXACT [] synonym: "leukocyte trafficking during immune response" EXACT [] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006955 ! immune response [Term] id: GO:0002523 name: leukocyte migration involved in inflammatory response namespace: biological_process def: "The movement of a leukocyte within or between different tissues and organs of the body contributing to an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:14680625, PMID:14708592, PMID:7507411, PMID:8600538] synonym: "immune cell migration during inflammatory response" RELATED [] synonym: "immune cell trafficking during inflammatory response" RELATED [] synonym: "leucocyte migration during inflammatory response" RELATED [] synonym: "leucocyte trafficking during inflammatory response" RELATED [] synonym: "leukocyte migration during inflammatory response" RELATED [GOC:dph] synonym: "leukocyte trafficking during inflammatory response" RELATED [] is_a: GO:0050900 ! leukocyte migration relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002524 name: hypersensitivity namespace: biological_process def: "An inflammatory response to an exogenous environmental antigen or an endogenous antigen initiated by the adaptive immune system." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "hypersensitivity response" RELATED [ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Hypersensitivity is_a: GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002525 name: acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "An acute inflammatory response to non-antigenic stimuli such as heat or physical trauma." [GOC:jal, PMID:16459497, PMID:9073326] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0002526 name: acute inflammatory response namespace: biological_process def: "Inflammation which comprises a rapid, short-lived, relatively uniform response to acute injury or antigenic challenge and is characterized by accumulations of fluid, plasma proteins, and granulocytic leukocytes. An acute inflammatory response occurs within a matter of minutes or hours, and either resolves within a few days or becomes a chronic inflammatory response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002527 name: vasodilation involved in acute inflammatory response namespace: biological_process def: "An increase in the internal diameter of blood vessels, especially arterioles or capillaries, usually resulting in a decrease in blood pressure contributing to an acute inflammatory response." [GOC:jal] synonym: "vasodilation during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0042311 ! vasodilation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002528 name: regulation of vascular permeability involved in acute inflammatory response namespace: biological_process def: "Any process that modulates the extent to which blood vessels can be pervaded by fluid contributing to an acute inflammatory response." [GOC:jal] synonym: "regulation of vascular permeability during acute inflammatory response" RELATED [GOC:dph] is_a: GO:0043114 ! regulation of vascular permeability relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002529 name: regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] is_a: GO:0002256 ! regulation of kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002530 name: regulation of systemic arterial blood pressure involved in acute-phase response namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, ISBN:081533642X] synonym: "blood pressure regulation during acute phase response" RELATED [] synonym: "regulation of systemic arterial blood pressure during acute phase response" RELATED [GOC:tb] is_a: GO:0003073 ! regulation of systemic arterial blood pressure relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002531 name: regulation of heart contraction involved in acute-phase response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction that contributes to the acute phase response. The acute phase response occurs during the early phases of an infection and is marked by changes in the production of plasma proteins such as C-reactive protein." [GOC:jal, PMID:15642986, PMID:15834430] synonym: "regulation of cardiac contraction during acute phase response" RELATED [] synonym: "regulation of heart contraction during acute phase response" RELATED [GOC:tb] is_a: GO:0008016 ! regulation of heart contraction relationship: part_of GO:0006953 ! acute-phase response [Term] id: GO:0002532 name: production of molecular mediator involved in inflammatory response namespace: biological_process def: "The synthesis or release of any molecular mediator of the inflammatory response following an inflammatory stimulus, resulting in an increase in its intracellular or extracellular levels." [GOC:add, GOC:dph, GOC:tb, ISBN:0781735149 "Fundamental Immunology"] synonym: "production of cellular mediator of acute inflammation" RELATED [] synonym: "production of molecular mediator involved in acute inflammatory response" BROAD [] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0006954 ! inflammatory response [Term] id: GO:0002533 name: secretion of lysosomal enzymes involved in inflammatory response namespace: biological_process def: "The regulated release of lysosomal enzymes by a cell or group of cells as part of an inflammatory response." [GOC:jal, PMID:11836514] synonym: "secretion of lysosomal enzymes involved in acute inflammatory response" BROAD [] is_a: GO:0033299 ! secretion of lysosomal enzymes relationship: part_of GO:0002393 ! production of lysosomal enzymes involved in inflammatory response [Term] id: GO:0002534 name: cytokine production involved in inflammatory response namespace: biological_process def: "The synthesis or release of a cytokine following a inflammatory stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "cytokine production involved in acute inflammatory response" BROAD [] is_a: GO:0001816 ! cytokine production is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002535 name: platelet activating factor secretion involved in inflammatory response namespace: biological_process def: "The regulated release of platelet activating factor by a cell or group of cells as part of an inflammatory response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "platelet activating factor secretion involved in acute inflammatory response" BROAD [] is_a: GO:0002392 ! platelet activating factor secretion relationship: part_of GO:0002391 ! platelet activating factor production involved in inflammatory response [Term] id: GO:0002536 name: respiratory burst involved in inflammatory response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases following a stimulus as part of an inflammatory response; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "oxidative burst during acute inflammatory response " BROAD [] synonym: "production of reactive oxygen species during acute inflammatory response" BROAD [] synonym: "respiratory burst involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response is_a: GO:0002679 ! respiratory burst involved in defense response [Term] id: GO:0002537 name: production of nitric oxide involved in inflammatory response namespace: biological_process def: "The synthesis or release of nitric oxide following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "production of nitric oxide involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002538 name: production of arachidonic acid metabolites involved in inflammatory response namespace: biological_process def: "The synthesis or release of products of arachidonic acid metabolism following a stimulus as part of an inflammatory response, resulting in an increase in their intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "production of arachidonic acid metabolites involved in acute inflammatory response" BROAD [] is_a: GO:0002532 ! production of molecular mediator involved in inflammatory response [Term] id: GO:0002539 name: prostaglandin production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any prostaglandin following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "prostaglandin production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! production of arachidonic acid metabolites involved in inflammatory response [Term] id: GO:0002540 name: leukotriene production involved in inflammatory response namespace: biological_process def: "The synthesis or release of any leukotriene following a stimulus as part of an inflammatory response, resulting in an increase in its intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "leukotriene production involved in acute inflammatory response" BROAD [] is_a: GO:0002538 ! production of arachidonic acid metabolites involved in inflammatory response [Term] id: GO:0002541 name: activation of plasma proteins involved in acute inflammatory response namespace: biological_process def: "Any process activating plasma proteins by proteolysis as part of an acute inflammatory response." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002542 name: Factor XII activation namespace: biological_process def: "Any process that activates Factor XII (Hageman factor). Factor XII is a protein synthesized by the liver that circulates in an inactive form until it encounters collagen or basement membrane or activated platelets (as occurs at the site of endothelial injury). Factor XII then undergoes a conformational change (becoming factor XIIa), exposing an active serine center that can subsequently cleave protein substrates and activate a variety of mediator systems. Factor XII is a participant in the clotting cascade as well as the kinin cascade." [GOC:jal, ISBN:0721601871] synonym: "Hageman factor activation" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0010954 ! positive regulation of protein maturation by peptide bond cleavage relationship: part_of GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002541 ! activation of plasma proteins involved in acute inflammatory response [Term] id: GO:0002543 name: activation of blood coagulation via clotting cascade namespace: biological_process def: "Any process that initiates the clotting cascade of blood coagulation, a cascade of plasma enzymes that is triggered following damage to blood vessels, leading to formation of a clot." [GOC:jal, ISBN:0781735149 "Fundamental Immunology"] synonym: "activation of clotting cascade" EXACT [] is_a: GO:0030194 ! positive regulation of blood coagulation relationship: part_of GO:0002526 ! acute inflammatory response [Term] id: GO:0002544 name: chronic inflammatory response namespace: biological_process def: "Inflammation of prolonged duration (weeks or months) in which active inflammation, tissue destruction, and attempts at repair are proceeding simultaneously. Although it may follow acute inflammation, chronic inflammation frequently begins insidiously, as a low-grade, smoldering, often asymptomatic response." [GO_REF:0000022, GOC:jal, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was added by GO_REF:0000022. is_a: GO:0006954 ! inflammatory response [Term] id: GO:0002545 name: chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "A chronic inflammatory response to a non-antigenic stimulus such as heat or physical trauma." [GOC:jal] is_a: GO:0002544 ! chronic inflammatory response [Term] id: GO:0002546 name: negative regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "downregulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "inhibition of tissue kallikrein-kinin cascade" NARROW [] synonym: "negative regulation of glandular kallikrein-kinin cascade" EXACT [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: negatively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002547 name: positive regulation of tissue kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the tissue kallikrein-kinin cascade." [GOC:add] synonym: "activation of tissue kallikrein-kinin cascade" NARROW [] synonym: "positive regulation of glandular kallikrein-kinin cascade" EXACT [] synonym: "stimulation of tissue kallikrein-kinin cascade" NARROW [] synonym: "up regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of tissue kallikrein-kinin cascade" EXACT [] synonym: "upregulation of tissue kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002382 ! regulation of tissue kallikrein-kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade relationship: positively_regulates GO:0002255 ! tissue kallikrein-kinin cascade [Term] id: GO:0002548 name: monocyte chemotaxis namespace: biological_process def: "The movement of a monocyte in response to an external stimulus." [GOC:add, PMID:11696603, PMID:15173832] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002549 name: negative regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "down regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "down-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "downregulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "inhibition of plasma kallikrein-kinin cascade" NARROW [] is_a: GO:0002257 ! negative regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: negatively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002550 name: positive regulation of plasma kallikrein-kinin cascade namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the plasma kallikrein-kinin cascade." [GOC:add] synonym: "activation of plasma kallikrein-kinin cascade" NARROW [] synonym: "stimulation of plasma kallikrein-kinin cascade" NARROW [] synonym: "up regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "up-regulation of plasma kallikrein-kinin cascade" EXACT [] synonym: "upregulation of plasma kallikrein-kinin cascade" EXACT [] is_a: GO:0002258 ! positive regulation of kinin cascade is_a: GO:0002529 ! regulation of plasma kallikrein-kinin cascade intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade relationship: positively_regulates GO:0002353 ! plasma kallikrein-kinin cascade [Term] id: GO:0002551 name: mast cell chemotaxis namespace: biological_process def: "The movement of a mast cell in response to an external stimulus." [GOC:add, PMID:11292027, PMID:12789214, PMID:16448392] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002552 name: serotonin secretion by mast cell namespace: biological_process def: "The regulated release of serotonin by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002553 name: histamine secretion by mast cell namespace: biological_process def: "The regulated release of histamine by a mast cell or group of mast cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0043303 ! mast cell degranulation [Term] id: GO:0002554 name: serotonin secretion by platelet namespace: biological_process def: "The regulated release of serotonin by a platelet or group of platelets." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002555 name: histamine secretion by platelet namespace: biological_process def: "The regulated release of histamine by a platelet or group of platelets." [GOC:add, PMID:9117517] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002576 ! platelet degranulation [Term] id: GO:0002556 name: serotonin secretion by basophil namespace: biological_process def: "The regulated release of serotonin by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002442 ! serotonin secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002557 name: histamine secretion by basophil namespace: biological_process def: "The regulated release of histamine by a basophil or group of basophils." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002441 ! histamine secretion involved in inflammatory response relationship: part_of GO:0002561 ! basophil degranulation [Term] id: GO:0002558 name: type I hypersensitivity mediated by mast cells namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors on mast cells, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002448 ! mast cell mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002559 name: type I hypersensitivity mediated by basophils namespace: biological_process def: "An inflammatory response driven by antigen recognition by antibodies bound to Fc receptors basophils, occurring within minutes after exposure of a sensitized individual to the antigen, and leading to the release of a variety of inflammatory mediators such as histamines." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002560 ! basophil mediated immunity is_a: GO:0016068 ! type I hypersensitivity [Term] id: GO:0002560 name: basophil mediated immunity namespace: biological_process def: "Any process involved in the carrying out of an immune response by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002561 name: basophil degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a basophil." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002276 ! basophil activation involved in immune response is_a: GO:0043299 ! leukocyte degranulation relationship: part_of GO:0002560 ! basophil mediated immunity [Term] id: GO:0002562 name: somatic diversification of immune receptors via germline recombination within a single locus namespace: biological_process def: "The process by which immune receptor genes are diversified through recombination of the germline genetic elements within a single genetic locus." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16102575, PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002563 name: somatic diversification of immune receptors via alternate splicing namespace: biological_process def: "The process by which immune receptor genes are diversified through alternate splicing." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:16166509] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002564 name: alternate splicing of immunoglobulin genes namespace: biological_process def: "The generation of alternate transcripts of immunoglobulin genes through alternate splicing of exons." [ISBN:0781735149 "Fundamental Immunology", PMID:9185563] synonym: "alternate splicing of antibody genes" EXACT [] is_a: GO:0002563 ! somatic diversification of immune receptors via alternate splicing is_a: GO:0016445 ! somatic diversification of immunoglobulins [Term] id: GO:0002565 name: somatic diversification of immune receptors via gene conversion namespace: biological_process def: "The process by which immune receptor genes are diversified through gene conversion." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002200 ! somatic diversification of immune receptors is_a: GO:0016444 ! somatic cell DNA recombination [Term] id: GO:0002566 name: somatic diversification of immune receptors via somatic mutation namespace: biological_process def: "The process by which immune receptor genes are diversified through somatic mutation." [ISBN:0781735149 "Fundamental Immunology", PMID:16102575] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002567 name: somatic diversification of FREP-based immune receptors namespace: biological_process def: "The process by means of which sequence diversity of the FREP-based immune receptors of snails is generated." [GOC:add, PMID:16102575] comment: Note that this type of immune receptor has been found in snails (Pulmonata, ncbi_axonomy_id:6519), but may also be seen in other species. is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002568 name: somatic diversification of T cell receptor genes namespace: biological_process def: "The somatic process by means of which sequence diversity of T cell receptor genes is generated." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of TCR genes" EXACT [] is_a: GO:0002200 ! somatic diversification of immune receptors relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002569 name: somatic diversification of immune receptors by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin and T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the immune receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002200 ! somatic diversification of immune receptors [Term] id: GO:0002570 name: somatic diversification of immunoglobulin genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of heavy chain immunoglobulin genes. N regions are found at the V-D and D-J recombinational junctions." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of antibody genes by N region addition" EXACT [] is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition is_a: GO:0016445 ! somatic diversification of immunoglobulins relationship: part_of GO:0016447 ! somatic recombination of immunoglobulin gene segments [Term] id: GO:0002571 name: somatic diversification of T cell receptor genes by N region addition namespace: biological_process def: "The addition of variable numbers of random nucleotides by terminal deoxytransferase in the N regions of T cell receptor genes. N regions are found at the V-D, D-D, V-J, and D-J recombinational junctions, depending on the T cell receptor gene." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic diversification of TCR genes by N region addition" EXACT [] is_a: GO:0002568 ! somatic diversification of T cell receptor genes is_a: GO:0002569 ! somatic diversification of immune receptors by N region addition relationship: part_of GO:0002681 ! somatic recombination of T cell receptor gene segments [Term] id: GO:0002572 name: pro-T cell differentiation namespace: biological_process def: "The process whereby a precursor cell type acquires the specialized features of a pro-T cell. Pro-T cells are the earliest stage of the T cell lineage but are not fully committed." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-T lymphocyte differentiation " EXACT [] is_a: GO:0002320 ! lymphoid progenitor cell differentiation relationship: part_of GO:0030217 ! T cell differentiation [Term] id: GO:0002573 name: myeloid leukocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of any cell of the myeloid leukocyte lineage." [GOC:add, PMID:16551251] synonym: "myeloid leucocyte differentiation" EXACT [] is_a: GO:0002521 ! leukocyte differentiation is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002574 name: thrombocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized myeloid precursor cell acquires the specialized features of a thrombocyte, a nucleated cell found in all vertebrates but mammals involved in hemostasis." [GOC:add] comment: Note that platelets are the non-nucleated mammalian functional equivalent of the nucleated thrombocytes of non-mammalian vertebrates and are sometimes also referred to as thrombocytes. Platelet formation in mammals is covered by the biological_process term platelet formation ; GO:0030220. is_a: GO:0030099 ! myeloid cell differentiation [Term] id: GO:0002575 name: basophil chemotaxis namespace: biological_process def: "The movement of a basophil in response to an external stimulus." [GOC:add, PMID:11292027] is_a: GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002576 name: platelet degranulation namespace: biological_process def: "The regulated exocytosis of secretory granules containing preformed mediators such as histamine and serotonin by a platelet." [GOC:add] synonym: "platelet exocytosis" EXACT [] xref: Reactome:114608 "Platelet degranulation" xref: Reactome:563163 "Platelet degranulation" xref: Reactome:588773 "Platelet degranulation" xref: Reactome:609499 "Platelet degranulation" xref: Reactome:634206 "Platelet degranulation" xref: Reactome:645705 "Platelet degranulation" xref: Reactome:656036 "Platelet degranulation" xref: Reactome:661215 "Platelet degranulation" xref: Reactome:666992 "Platelet degranulation" xref: Reactome:673131 "Platelet degranulation" xref: Reactome:678827 "Platelet degranulation" xref: Reactome:683759 "Platelet degranulation" xref: Reactome:689981 "Platelet degranulation" xref: Reactome:701754 "Platelet degranulation" xref: Reactome:716330 "Platelet degranulation" xref: Reactome:720829 "Platelet degranulation" xref: Reactome:728274 "Platelet degranulation" xref: Reactome:731099 "Platelet degranulation" xref: Reactome:733101 "Platelet degranulation" xref: Reactome:735650 "Platelet degranulation" xref: Reactome:736591 "Platelet degranulation" xref: Reactome:738618 "Platelet degranulation" is_a: GO:0006887 ! exocytosis [Term] id: GO:0002577 name: regulation of antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019882 ! antigen processing and presentation relationship: regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002578 name: negative regulation of antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "down regulation of antigen processing and presentation" EXACT [] synonym: "down-regulation of antigen processing and presentation" EXACT [] synonym: "downregulation of antigen processing and presentation" EXACT [] synonym: "inhibition of antigen processing and presentation" NARROW [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019882 ! antigen processing and presentation relationship: negatively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002579 name: positive regulation of antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation." [GOC:add] synonym: "activation of antigen processing and presentation" NARROW [] synonym: "stimulation of antigen processing and presentation" NARROW [] synonym: "up regulation of antigen processing and presentation" EXACT [] synonym: "up-regulation of antigen processing and presentation" EXACT [] synonym: "upregulation of antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019882 ! antigen processing and presentation relationship: positively_regulates GO:0019882 ! antigen processing and presentation [Term] id: GO:0002580 name: regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002581 name: negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002582 name: positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen (peptide or polysaccharide) via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide or polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002504 ! antigen processing and presentation of peptide or polysaccharide antigen via MHC class II [Term] id: GO:0002583 name: regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002584 name: negative regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: negatively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002585 name: positive regulation of antigen processing and presentation of peptide antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen relationship: positively_regulates GO:0048002 ! antigen processing and presentation of peptide antigen [Term] id: GO:0002586 name: regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002587 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: negatively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002588 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002586 ! regulation of antigen processing and presentation of peptide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II relationship: positively_regulates GO:0002495 ! antigen processing and presentation of peptide antigen via MHC class II [Term] id: GO:0002589 name: regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002590 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class I" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: negatively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002591 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class I namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class I." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class I" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class I" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class I" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002589 ! regulation of antigen processing and presentation of peptide antigen via MHC class I intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I relationship: positively_regulates GO:0002474 ! antigen processing and presentation of peptide antigen via MHC class I [Term] id: GO:0002592 name: regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002593 name: negative regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation via MHC class Ib" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: negatively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002594 name: positive regulation of antigen processing and presentation via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "stimulation of antigen processing and presentation via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib relationship: positively_regulates GO:0002475 ! antigen processing and presentation via MHC class Ib [Term] id: GO:0002595 name: regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002596 name: negative regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "negative regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002584 ! negative regulation of antigen processing and presentation of peptide antigen is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: negatively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002597 name: positive regulation of antigen processing and presentation of peptide antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of peptide antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "positive regulation of peptide antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of peptide antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of peptide antigen via MHC class Ib" EXACT [] is_a: GO:0002585 ! positive regulation of antigen processing and presentation of peptide antigen is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002595 ! regulation of antigen processing and presentation of peptide antigen via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib relationship: positively_regulates GO:0002428 ! antigen processing and presentation of peptide antigen via MHC class Ib [Term] id: GO:0002598 name: regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002592 ! regulation of antigen processing and presentation via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002599 name: negative regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "down regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "down-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "downregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "inhibition of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "negative regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] is_a: GO:0002593 ! negative regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: negatively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002600 name: positive regulation of antigen processing and presentation of lipid antigen via MHC class Ib namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of lipid antigen via MHC class Ib." [GOC:add] synonym: "activation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "positive regulation of lipid antigen processing and presentation via MHC class Ib" EXACT [] synonym: "stimulation of antigen processing and presentation of lipid antigen via MHC class Ib" NARROW [] synonym: "up regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "up-regulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] synonym: "upregulation of antigen processing and presentation of lipid antigen via MHC class Ib" EXACT [] is_a: GO:0002594 ! positive regulation of antigen processing and presentation via MHC class Ib is_a: GO:0002598 ! regulation of antigen processing and presentation of lipid antigen via MHC class Ib intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib relationship: positively_regulates GO:0048003 ! antigen processing and presentation of lipid antigen via MHC class Ib [Term] id: GO:0002601 name: regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002580 ! regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002602 name: negative regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "down regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "down-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "downregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "inhibition of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "negative regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] is_a: GO:0002581 ! negative regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: negatively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002603 name: positive regulation of antigen processing and presentation of polysaccharide antigen via MHC class II namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antigen processing and presentation of polysaccharide antigen via MHC class II." [GOC:add] synonym: "activation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "positive regulation of polysaccharide antigen processing and presentation via MHC class II" EXACT [] synonym: "stimulation of antigen processing and presentation of polysaccharide antigen via MHC class II" NARROW [] synonym: "up regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "up-regulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] synonym: "upregulation of antigen processing and presentation of polysaccharide antigen via MHC class II" EXACT [] is_a: GO:0002582 ! positive regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II is_a: GO:0002601 ! regulation of antigen processing and presentation of polysaccharide antigen via MHC class II intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II relationship: positively_regulates GO:0002505 ! antigen processing and presentation of polysaccharide antigen via MHC class II [Term] id: GO:0002604 name: regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002605 name: negative regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002606 name: positive regulation of dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002468 ! dendritic cell antigen processing and presentation [Term] id: GO:0002607 name: regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002608 name: negative regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of myeloid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002609 name: positive regulation of myeloid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of myeloid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of myeloid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of myeloid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002607 ! regulation of myeloid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002469 ! myeloid dendritic cell antigen processing and presentation [Term] id: GO:0002610 name: regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] is_a: GO:0002604 ! regulation of dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002611 name: negative regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] is_a: GO:0002605 ! negative regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: negatively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002612 name: positive regulation of plasmacytoid dendritic cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell antigen processing and presentation." [GOC:add] synonym: "activation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell antigen processing and presentation" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell antigen processing and presentation" EXACT [] is_a: GO:0002606 ! positive regulation of dendritic cell antigen processing and presentation is_a: GO:0002610 ! regulation of plasmacytoid dendritic cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation relationship: positively_regulates GO:0002470 ! plasmacytoid dendritic cell antigen processing and presentation [Term] id: GO:0002613 name: regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002471 ! monocyte antigen processing and presentation relationship: regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002614 name: negative regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "down regulation of monocyte antigen processing and presentation" EXACT [] synonym: "down-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "downregulation of monocyte antigen processing and presentation" EXACT [] synonym: "inhibition of monocyte antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation relationship: negatively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002615 name: positive regulation of monocyte antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of monocyte antigen processing and presentation." [GOC:add] synonym: "activation of monocyte antigen processing and presentation" NARROW [] synonym: "stimulation of monocyte antigen processing and presentation" NARROW [] synonym: "up regulation of monocyte antigen processing and presentation" EXACT [] synonym: "up-regulation of monocyte antigen processing and presentation" EXACT [] synonym: "upregulation of monocyte antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002613 ! regulation of monocyte antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002471 ! monocyte antigen processing and presentation relationship: positively_regulates GO:0002471 ! monocyte antigen processing and presentation [Term] id: GO:0002616 name: regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002472 ! macrophage antigen processing and presentation relationship: regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002617 name: negative regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "down regulation of macrophage antigen processing and presentation" EXACT [] synonym: "down-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "downregulation of macrophage antigen processing and presentation" EXACT [] synonym: "inhibition of macrophage antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation relationship: negatively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002618 name: positive regulation of macrophage antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of macrophage antigen processing and presentation." [GOC:add] synonym: "activation of macrophage antigen processing and presentation" NARROW [] synonym: "stimulation of macrophage antigen processing and presentation" NARROW [] synonym: "up regulation of macrophage antigen processing and presentation" EXACT [] synonym: "up-regulation of macrophage antigen processing and presentation" EXACT [] synonym: "upregulation of macrophage antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002616 ! regulation of macrophage antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002472 ! macrophage antigen processing and presentation relationship: positively_regulates GO:0002472 ! macrophage antigen processing and presentation [Term] id: GO:0002619 name: regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] is_a: GO:0002577 ! regulation of antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002620 name: negative regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "down regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "down-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "downregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "inhibition of non-professional antigen presenting cell antigen processing and presentation" NARROW [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: negatively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002621 name: positive regulation of non-professional antigen presenting cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of non-professional antigen presenting cell antigen processing and presentation." [GOC:add] synonym: "activation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "stimulation of non-professional antigen presenting cell antigen processing and presentation" NARROW [] synonym: "up regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "up-regulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] synonym: "upregulation of non-professional antigen presenting cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002619 ! regulation of non-professional antigen presenting cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation relationship: positively_regulates GO:0002473 ! non-professional antigen presenting cell antigen processing and presentation [Term] id: GO:0002622 name: regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of B-cell antigen processing and presentation" EXACT [] synonym: "regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002450 ! B cell antigen processing and presentation relationship: regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002623 name: negative regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "down regulation of B cell antigen processing and presentation" EXACT [] synonym: "down-regulation of B cell antigen processing and presentation" EXACT [] synonym: "downregulation of B cell antigen processing and presentation" EXACT [] synonym: "inhibition of B cell antigen processing and presentation" NARROW [] synonym: "negative regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of B-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of B-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002450 ! B cell antigen processing and presentation relationship: negatively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002624 name: positive regulation of B cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell antigen processing and presentation." [GOC:add] synonym: "activation of B cell antigen processing and presentation" NARROW [] synonym: "positive regulation of B lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of B-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of B-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of B cell antigen processing and presentation" NARROW [] synonym: "up regulation of B cell antigen processing and presentation" EXACT [] synonym: "up-regulation of B cell antigen processing and presentation" EXACT [] synonym: "upregulation of B cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002622 ! regulation of B cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002450 ! B cell antigen processing and presentation relationship: positively_regulates GO:0002450 ! B cell antigen processing and presentation [Term] id: GO:0002625 name: regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "regulation of T-cell antigen processing and presentation" EXACT [] synonym: "regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002577 ! regulation of antigen processing and presentation is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002457 ! T cell antigen processing and presentation relationship: regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002626 name: negative regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "down regulation of T cell antigen processing and presentation" EXACT [] synonym: "down-regulation of T cell antigen processing and presentation" EXACT [] synonym: "downregulation of T cell antigen processing and presentation" EXACT [] synonym: "inhibition of T cell antigen processing and presentation" NARROW [] synonym: "negative regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "negative regulation of T-cell antigen processing and presentation" EXACT [] synonym: "negative regulation of T-lymphocyte antigen processing and presentation" EXACT [] is_a: GO:0002578 ! negative regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002457 ! T cell antigen processing and presentation relationship: negatively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002627 name: positive regulation of T cell antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell antigen processing and presentation." [GOC:add] synonym: "activation of T cell antigen processing and presentation" NARROW [] synonym: "positive regulation of T lymphocyte antigen processing and presentation" EXACT [] synonym: "positive regulation of T-cell antigen processing and presentation" EXACT [] synonym: "positive regulation of T-lymphocyte antigen processing and presentation" EXACT [] synonym: "stimulation of T cell antigen processing and presentation" NARROW [] synonym: "up regulation of T cell antigen processing and presentation" EXACT [] synonym: "up-regulation of T cell antigen processing and presentation" EXACT [] synonym: "upregulation of T cell antigen processing and presentation" EXACT [] is_a: GO:0002579 ! positive regulation of antigen processing and presentation is_a: GO:0002625 ! regulation of T cell antigen processing and presentation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002457 ! T cell antigen processing and presentation relationship: positively_regulates GO:0002457 ! T cell antigen processing and presentation [Term] id: GO:0002628 name: regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] is_a: GO:0002583 ! regulation of antigen processing and presentation of peptide antigen is_a: GO:0030162 ! regulation of proteolysis is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0032268 ! regulation of cellular protein metabolic process is_a: GO:0042176 ! regulation of protein catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002629 name: negative regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "down regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "down-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "downregulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "inhibition of proteolysis associated with antigen processing and presentation" NARROW [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031330 ! negative regulation of cellular catabolic process is_a: GO:0042177 ! negative regulation of protein catabolic process is_a: GO:0045861 ! negative regulation of proteolysis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: negatively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002630 name: positive regulation of proteolysis associated with antigen processing and presentation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of proteolysis associated with antigen processing and presentation." [GOC:add] synonym: "activation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "stimulation of proteolysis associated with antigen processing and presentation" NARROW [] synonym: "up regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "up-regulation of proteolysis associated with antigen processing and presentation" EXACT [] synonym: "upregulation of proteolysis associated with antigen processing and presentation" EXACT [] is_a: GO:0002628 ! regulation of proteolysis associated with antigen processing and presentation is_a: GO:0031331 ! positive regulation of cellular catabolic process is_a: GO:0045732 ! positive regulation of protein catabolic process is_a: GO:0045862 ! positive regulation of proteolysis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation relationship: positively_regulates GO:0002496 ! proteolysis associated with antigen processing and presentation [Term] id: GO:0002631 name: regulation of granuloma formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of granuloma formation." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002432 ! granuloma formation relationship: regulates GO:0002432 ! granuloma formation [Term] id: GO:0002632 name: negative regulation of granuloma formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "down regulation of granuloma formation" EXACT [] synonym: "down-regulation of granuloma formation" EXACT [] synonym: "downregulation of granuloma formation" EXACT [] synonym: "inhibition of granuloma formation" NARROW [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002698 ! negative regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002432 ! granuloma formation relationship: negatively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002633 name: positive regulation of granuloma formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of granuloma formation." [GOC:add] synonym: "activation of granuloma formation" NARROW [] synonym: "stimulation of granuloma formation" NARROW [] synonym: "up regulation of granuloma formation" EXACT [] synonym: "up-regulation of granuloma formation" EXACT [] synonym: "upregulation of granuloma formation" EXACT [] is_a: GO:0002631 ! regulation of granuloma formation is_a: GO:0002699 ! positive regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002432 ! granuloma formation relationship: positively_regulates GO:0002432 ! granuloma formation [Term] id: GO:0002634 name: regulation of germinal center formation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of germinal center formation." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002467 ! germinal center formation relationship: regulates GO:0002467 ! germinal center formation [Term] id: GO:0002635 name: negative regulation of germinal center formation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "down regulation of germinal center formation" EXACT [] synonym: "down-regulation of germinal center formation" EXACT [] synonym: "downregulation of germinal center formation" EXACT [] synonym: "inhibition of germinal center formation" NARROW [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002467 ! germinal center formation relationship: negatively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002636 name: positive regulation of germinal center formation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of germinal center formation." [GOC:add] synonym: "activation of germinal center formation" NARROW [] synonym: "stimulation of germinal center formation" NARROW [] synonym: "up regulation of germinal center formation" EXACT [] synonym: "up-regulation of germinal center formation" EXACT [] synonym: "upregulation of germinal center formation" EXACT [] is_a: GO:0002634 ! regulation of germinal center formation is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002467 ! germinal center formation relationship: positively_regulates GO:0002467 ! germinal center formation [Term] id: GO:0002637 name: regulation of immunoglobulin production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002377 ! immunoglobulin production relationship: regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002638 name: negative regulation of immunoglobulin production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "down regulation of immunoglobulin production" EXACT [] synonym: "down-regulation of immunoglobulin production" EXACT [] synonym: "downregulation of immunoglobulin production" EXACT [] synonym: "inhibition of immunoglobulin production" NARROW [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002377 ! immunoglobulin production relationship: negatively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002639 name: positive regulation of immunoglobulin production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin production." [GOC:add] synonym: "activation of immunoglobulin production" NARROW [] synonym: "stimulation of immunoglobulin production" NARROW [] synonym: "up regulation of immunoglobulin production" EXACT [] synonym: "up-regulation of immunoglobulin production" EXACT [] synonym: "upregulation of immunoglobulin production" EXACT [] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002377 ! immunoglobulin production relationship: positively_regulates GO:0002377 ! immunoglobulin production [Term] id: GO:0002640 name: regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] is_a: GO:0002637 ! regulation of immunoglobulin production is_a: GO:0010556 ! regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002641 name: negative regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "down regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "down-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "downregulation of immunoglobulin biosynthetic process" EXACT [] synonym: "inhibition of immunoglobulin biosynthetic process" NARROW [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: negatively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002642 name: positive regulation of immunoglobulin biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of immunoglobulin biosynthesis." [GOC:add] synonym: "activation of immunoglobulin biosynthetic process" NARROW [] synonym: "stimulation of immunoglobulin biosynthetic process" NARROW [] synonym: "up regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "up-regulation of immunoglobulin biosynthetic process" EXACT [] synonym: "upregulation of immunoglobulin biosynthetic process" EXACT [] is_a: GO:0002640 ! regulation of immunoglobulin biosynthetic process is_a: GO:0010557 ! positive regulation of macromolecule biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process relationship: positively_regulates GO:0002378 ! immunoglobulin biosynthetic process [Term] id: GO:0002643 name: regulation of tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction." [GOC:add] is_a: GO:0002682 ! regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002507 ! tolerance induction relationship: regulates GO:0002507 ! tolerance induction [Term] id: GO:0002644 name: negative regulation of tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "down regulation of tolerance induction" EXACT [] synonym: "down-regulation of tolerance induction" EXACT [] synonym: "downregulation of tolerance induction" EXACT [] synonym: "inhibition of tolerance induction" NARROW [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002683 ! negative regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002507 ! tolerance induction relationship: negatively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002645 name: positive regulation of tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction." [GOC:add] synonym: "activation of tolerance induction" NARROW [] synonym: "stimulation of tolerance induction" NARROW [] synonym: "up regulation of tolerance induction" EXACT [] synonym: "up-regulation of tolerance induction" EXACT [] synonym: "upregulation of tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002684 ! positive regulation of immune system process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002507 ! tolerance induction relationship: positively_regulates GO:0002507 ! tolerance induction [Term] id: GO:0002646 name: regulation of central tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central tolerance induction." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002508 ! central tolerance induction relationship: regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002647 name: negative regulation of central tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "down regulation of central tolerance induction" EXACT [] synonym: "down-regulation of central tolerance induction" EXACT [] synonym: "downregulation of central tolerance induction" EXACT [] synonym: "inhibition of central tolerance induction" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002508 ! central tolerance induction relationship: negatively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002648 name: positive regulation of central tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central tolerance induction." [GOC:add] synonym: "activation of central tolerance induction" NARROW [] synonym: "stimulation of central tolerance induction" NARROW [] synonym: "up regulation of central tolerance induction" EXACT [] synonym: "up-regulation of central tolerance induction" EXACT [] synonym: "upregulation of central tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002646 ! regulation of central tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002508 ! central tolerance induction relationship: positively_regulates GO:0002508 ! central tolerance induction [Term] id: GO:0002649 name: regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002513 ! tolerance induction to self antigen relationship: regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002650 name: negative regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "down regulation of tolerance induction to self antigen" EXACT [] synonym: "down-regulation of tolerance induction to self antigen" EXACT [] synonym: "downregulation of tolerance induction to self antigen" EXACT [] synonym: "inhibition of tolerance induction to self antigen" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002513 ! tolerance induction to self antigen relationship: negatively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002651 name: positive regulation of tolerance induction to self antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to self antigen." [GOC:add] synonym: "activation of tolerance induction to self antigen" NARROW [] synonym: "stimulation of tolerance induction to self antigen" NARROW [] synonym: "up regulation of tolerance induction to self antigen" EXACT [] synonym: "up-regulation of tolerance induction to self antigen" EXACT [] synonym: "upregulation of tolerance induction to self antigen" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002649 ! regulation of tolerance induction to self antigen intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002513 ! tolerance induction to self antigen relationship: positively_regulates GO:0002513 ! tolerance induction to self antigen [Term] id: GO:0002652 name: regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002653 name: negative regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "down regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "down-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "downregulation of tolerance induction dependent upon immune response" EXACT [] synonym: "inhibition of tolerance induction dependent upon immune response" NARROW [] synonym: "negative regulation of immune response-dependent tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: negatively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002654 name: positive regulation of tolerance induction dependent upon immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction dependent upon immune response." [GOC:add] synonym: "activation of tolerance induction dependent upon immune response" NARROW [] synonym: "positive regulation of immune response-dependent tolerance induction" EXACT [] synonym: "stimulation of tolerance induction dependent upon immune response" NARROW [] synonym: "up regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "up-regulation of tolerance induction dependent upon immune response" EXACT [] synonym: "upregulation of tolerance induction dependent upon immune response" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response relationship: positively_regulates GO:0002461 ! tolerance induction dependent upon immune response [Term] id: GO:0002655 name: regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002462 ! tolerance induction to nonself antigen relationship: regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002656 name: negative regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "down regulation of tolerance induction to nonself antigen" EXACT [] synonym: "down-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "downregulation of tolerance induction to nonself antigen" EXACT [] synonym: "inhibition of tolerance induction to nonself antigen" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen relationship: negatively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002657 name: positive regulation of tolerance induction to nonself antigen namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to nonself antigen." [GOC:add] synonym: "activation of tolerance induction to nonself antigen" NARROW [] synonym: "stimulation of tolerance induction to nonself antigen" NARROW [] synonym: "up regulation of tolerance induction to nonself antigen" EXACT [] synonym: "up-regulation of tolerance induction to nonself antigen" EXACT [] synonym: "upregulation of tolerance induction to nonself antigen" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002655 ! regulation of tolerance induction to nonself antigen intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002462 ! tolerance induction to nonself antigen relationship: positively_regulates GO:0002462 ! tolerance induction to nonself antigen [Term] id: GO:0002658 name: regulation of peripheral tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] is_a: GO:0002652 ! regulation of tolerance induction dependent upon immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002465 ! peripheral tolerance induction relationship: regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002659 name: negative regulation of peripheral tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "down regulation of peripheral tolerance induction" EXACT [] synonym: "down-regulation of peripheral tolerance induction" EXACT [] synonym: "downregulation of peripheral tolerance induction" EXACT [] synonym: "inhibition of peripheral tolerance induction" NARROW [] is_a: GO:0002653 ! negative regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002465 ! peripheral tolerance induction relationship: negatively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002660 name: positive regulation of peripheral tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral tolerance induction." [GOC:add] synonym: "activation of peripheral tolerance induction" NARROW [] synonym: "stimulation of peripheral tolerance induction" NARROW [] synonym: "up regulation of peripheral tolerance induction" EXACT [] synonym: "up-regulation of peripheral tolerance induction" EXACT [] synonym: "upregulation of peripheral tolerance induction" EXACT [] is_a: GO:0002654 ! positive regulation of tolerance induction dependent upon immune response is_a: GO:0002658 ! regulation of peripheral tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002465 ! peripheral tolerance induction relationship: positively_regulates GO:0002465 ! peripheral tolerance induction [Term] id: GO:0002661 name: regulation of B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "regulation of B lymphocyte tolerance induction" EXACT [] synonym: "regulation of B-cell tolerance induction" EXACT [] synonym: "regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002514 ! B cell tolerance induction relationship: regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002662 name: negative regulation of B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "down regulation of B cell tolerance induction" EXACT [] synonym: "down-regulation of B cell tolerance induction" EXACT [] synonym: "downregulation of B cell tolerance induction" EXACT [] synonym: "inhibition of B cell tolerance induction" NARROW [] synonym: "negative regulation of B lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of B-cell tolerance induction" EXACT [] synonym: "negative regulation of B-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002514 ! B cell tolerance induction relationship: negatively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002663 name: positive regulation of B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell tolerance induction." [GOC:add] synonym: "activation of B cell tolerance induction" NARROW [] synonym: "positive regulation of B lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of B-cell tolerance induction" EXACT [] synonym: "positive regulation of B-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of B cell tolerance induction" NARROW [] synonym: "up regulation of B cell tolerance induction" EXACT [] synonym: "up-regulation of B cell tolerance induction" EXACT [] synonym: "upregulation of B cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002514 ! B cell tolerance induction relationship: positively_regulates GO:0002514 ! B cell tolerance induction [Term] id: GO:0002664 name: regulation of T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "regulation of T lymphocyte tolerance induction" EXACT [] synonym: "regulation of T-cell tolerance induction" EXACT [] synonym: "regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002517 ! T cell tolerance induction relationship: regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002665 name: negative regulation of T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "down regulation of T cell tolerance induction" EXACT [] synonym: "down-regulation of T cell tolerance induction" EXACT [] synonym: "downregulation of T cell tolerance induction" EXACT [] synonym: "inhibition of T cell tolerance induction" NARROW [] synonym: "negative regulation of T lymphocyte tolerance induction" EXACT [] synonym: "negative regulation of T-cell tolerance induction" EXACT [] synonym: "negative regulation of T-lymphocyte tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002517 ! T cell tolerance induction relationship: negatively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002666 name: positive regulation of T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction." [GOC:add] synonym: "activation of T cell tolerance induction" NARROW [] synonym: "positive regulation of T lymphocyte tolerance induction" EXACT [] synonym: "positive regulation of T-cell tolerance induction" EXACT [] synonym: "positive regulation of T-lymphocyte tolerance induction" EXACT [] synonym: "stimulation of T cell tolerance induction" NARROW [] synonym: "up regulation of T cell tolerance induction" EXACT [] synonym: "up-regulation of T cell tolerance induction" EXACT [] synonym: "upregulation of T cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002517 ! T cell tolerance induction relationship: positively_regulates GO:0002517 ! T cell tolerance induction [Term] id: GO:0002667 name: regulation of T cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "regulation of T lymphocyte anergy" EXACT [] synonym: "regulation of T-cell anergy" EXACT [] synonym: "regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002870 ! T cell anergy relationship: regulates GO:0002870 ! T cell anergy [Term] id: GO:0002668 name: negative regulation of T cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "down regulation of T cell anergy" EXACT [] synonym: "down-regulation of T cell anergy" EXACT [] synonym: "downregulation of T cell anergy" EXACT [] synonym: "inhibition of T cell anergy" NARROW [] synonym: "negative regulation of T lymphocyte anergy" EXACT [] synonym: "negative regulation of T-cell anergy" EXACT [] synonym: "negative regulation of T-lymphocyte anergy" EXACT [] is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002870 ! T cell anergy relationship: negatively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002669 name: positive regulation of T cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell anergy." [GOC:add] synonym: "activation of T cell anergy" NARROW [] synonym: "positive regulation of T lymphocyte anergy" EXACT [] synonym: "positive regulation of T-cell anergy" EXACT [] synonym: "positive regulation of T-lymphocyte anergy" EXACT [] synonym: "stimulation of T cell anergy" NARROW [] synonym: "up regulation of T cell anergy" EXACT [] synonym: "up-regulation of T cell anergy" EXACT [] synonym: "upregulation of T cell anergy" EXACT [] is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002667 ! regulation of T cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002870 ! T cell anergy relationship: positively_regulates GO:0002870 ! T cell anergy [Term] id: GO:0002670 name: regulation of B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "regulation of B lymphocyte anergy" EXACT [] synonym: "regulation of B-cell anergy" EXACT [] synonym: "regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002515 ! B cell anergy relationship: regulates GO:0002515 ! B cell anergy [Term] id: GO:0002671 name: negative regulation of B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "down regulation of B cell anergy" EXACT [] synonym: "down-regulation of B cell anergy" EXACT [] synonym: "downregulation of B cell anergy" EXACT [] synonym: "inhibition of B cell anergy" NARROW [] synonym: "negative regulation of B lymphocyte anergy" EXACT [] synonym: "negative regulation of B-cell anergy" EXACT [] synonym: "negative regulation of B-lymphocyte anergy" EXACT [] is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002912 ! negative regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002515 ! B cell anergy relationship: negatively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002672 name: positive regulation of B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell anergy." [GOC:add] synonym: "activation of B cell anergy" NARROW [] synonym: "positive regulation of B lymphocyte anergy" EXACT [] synonym: "positive regulation of B-cell anergy" EXACT [] synonym: "positive regulation of B-lymphocyte anergy" EXACT [] synonym: "stimulation of B cell anergy" NARROW [] synonym: "up regulation of B cell anergy" EXACT [] synonym: "up-regulation of B cell anergy" EXACT [] synonym: "upregulation of B cell anergy" EXACT [] is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002913 ! positive regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002515 ! B cell anergy relationship: positively_regulates GO:0002515 ! B cell anergy [Term] id: GO:0002673 name: regulation of acute inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002526 ! acute inflammatory response relationship: regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002674 name: negative regulation of acute inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "down regulation of acute inflammatory response" EXACT [] synonym: "down-regulation of acute inflammatory response" EXACT [] synonym: "downregulation of acute inflammatory response" EXACT [] synonym: "inhibition of acute inflammatory response" NARROW [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002526 ! acute inflammatory response relationship: negatively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002675 name: positive regulation of acute inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response." [GOC:add] synonym: "activation of acute inflammatory response" NARROW [] synonym: "stimulation of acute inflammatory response" NARROW [] synonym: "up regulation of acute inflammatory response" EXACT [] synonym: "up-regulation of acute inflammatory response" EXACT [] synonym: "upregulation of acute inflammatory response" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002526 ! acute inflammatory response relationship: positively_regulates GO:0002526 ! acute inflammatory response [Term] id: GO:0002676 name: regulation of chronic inflammatory response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002544 ! chronic inflammatory response relationship: regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002677 name: negative regulation of chronic inflammatory response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "down regulation of chronic inflammatory response" EXACT [] synonym: "down-regulation of chronic inflammatory response" EXACT [] synonym: "downregulation of chronic inflammatory response" EXACT [] synonym: "inhibition of chronic inflammatory response" NARROW [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050728 ! negative regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002544 ! chronic inflammatory response relationship: negatively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002678 name: positive regulation of chronic inflammatory response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response." [GOC:add] synonym: "activation of chronic inflammatory response" NARROW [] synonym: "stimulation of chronic inflammatory response" NARROW [] synonym: "up regulation of chronic inflammatory response" EXACT [] synonym: "up-regulation of chronic inflammatory response" EXACT [] synonym: "upregulation of chronic inflammatory response" EXACT [] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0050729 ! positive regulation of inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002544 ! chronic inflammatory response relationship: positively_regulates GO:0002544 ! chronic inflammatory response [Term] id: GO:0002679 name: respiratory burst involved in defense response namespace: biological_process def: "A phase of elevated metabolic activity, during which oxygen consumption increases made as part of a defense response ; this leads to the production, by an NADH dependent system, of hydrogen peroxide (H2O2), superoxide anions and hydroxyl radicals." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12789499] is_a: GO:0002252 ! immune effector process is_a: GO:0045730 ! respiratory burst relationship: part_of GO:0006952 ! defense response [Term] id: GO:0002680 name: pro-T cell lineage commitment namespace: biological_process def: "The process by which a lymphoid progenitor cell becomes committed to becoming a pro-T cell." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "pro-T cell fate commitment" EXACT [] synonym: "pro-T lymphocyte fate commitment" EXACT [] synonym: "pro-T lymphocyte lineage commitment" EXACT [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0002572 ! pro-T cell differentiation [Term] id: GO:0002681 name: somatic recombination of T cell receptor gene segments namespace: biological_process def: "The process by which T cell receptor genes are formed through recombination of the germline genetic elements, also known as T cell receptor gene segments." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "somatic recombination of TCR gene segments" EXACT [] is_a: GO:0002562 ! somatic diversification of immune receptors via germline recombination within a single locus is_a: GO:0002568 ! somatic diversification of T cell receptor genes [Term] id: GO:0002682 name: regulation of immune system process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune system process." [GOC:add] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002376 ! immune system process relationship: regulates GO:0002376 ! immune system process [Term] id: GO:0002683 name: negative regulation of immune system process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "down regulation of immune system process" EXACT [] synonym: "down-regulation of immune system process" EXACT [] synonym: "downregulation of immune system process" EXACT [] synonym: "inhibition of immune system process" NARROW [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002376 ! immune system process relationship: negatively_regulates GO:0002376 ! immune system process [Term] id: GO:0002684 name: positive regulation of immune system process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune system process." [GOC:add] synonym: "activation of immune system process" NARROW [] synonym: "stimulation of immune system process" NARROW [] synonym: "up regulation of immune system process" EXACT [] synonym: "up-regulation of immune system process" EXACT [] synonym: "upregulation of immune system process" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002376 ! immune system process relationship: positively_regulates GO:0002376 ! immune system process [Term] id: GO:0002685 name: regulation of leukocyte migration namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "regulation of immune cell migration" EXACT [] synonym: "regulation of leucocyte migration" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0030334 ! regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0050900 ! leukocyte migration relationship: regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002686 name: negative regulation of leukocyte migration namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "down regulation of leukocyte migration" EXACT [] synonym: "down-regulation of leukocyte migration" EXACT [] synonym: "downregulation of leukocyte migration" EXACT [] synonym: "inhibition of leukocyte migration" NARROW [] synonym: "negative regulation of immune cell migration" EXACT [] synonym: "negative regulation of leucocyte migration" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030336 ! negative regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0050900 ! leukocyte migration relationship: negatively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002687 name: positive regulation of leukocyte migration namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte migration." [GOC:add] synonym: "activation of leukocyte migration" NARROW [] synonym: "positive regulation of immune cell migration" EXACT [] synonym: "positive regulation of leucocyte migration" EXACT [] synonym: "stimulation of leukocyte migration" NARROW [] synonym: "up regulation of leukocyte migration" EXACT [] synonym: "up-regulation of leukocyte migration" EXACT [] synonym: "upregulation of leukocyte migration" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0030335 ! positive regulation of cell migration intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0050900 ! leukocyte migration relationship: positively_regulates GO:0050900 ! leukocyte migration [Term] id: GO:0002688 name: regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "regulation of immune cell chemotaxis" EXACT [] synonym: "regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002685 ! regulation of leukocyte migration is_a: GO:0050920 ! regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030595 ! leukocyte chemotaxis relationship: regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002689 name: negative regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "down regulation of leukocyte chemotaxis" EXACT [] synonym: "down-regulation of leukocyte chemotaxis" EXACT [] synonym: "downregulation of leukocyte chemotaxis" EXACT [] synonym: "inhibition of leukocyte chemotaxis" NARROW [] synonym: "negative regulation of immune cell chemotaxis" EXACT [] synonym: "negative regulation of leucocyte chemotaxis" EXACT [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050922 ! negative regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030595 ! leukocyte chemotaxis relationship: negatively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002690 name: positive regulation of leukocyte chemotaxis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte chemotaxis." [GOC:add] synonym: "activation of leukocyte chemotaxis" NARROW [] synonym: "positive regulation of immune cell chemotaxis" EXACT [] synonym: "positive regulation of leucocyte chemotaxis" EXACT [] synonym: "stimulation of leukocyte chemotaxis" NARROW [] synonym: "up regulation of leukocyte chemotaxis" EXACT [] synonym: "up-regulation of leukocyte chemotaxis" EXACT [] synonym: "upregulation of leukocyte chemotaxis" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002688 ! regulation of leukocyte chemotaxis is_a: GO:0050921 ! positive regulation of chemotaxis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030595 ! leukocyte chemotaxis relationship: positively_regulates GO:0030595 ! leukocyte chemotaxis [Term] id: GO:0002691 name: regulation of cellular extravasation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cellular extravasation." [GOC:add] is_a: GO:0002685 ! regulation of leukocyte migration intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045123 ! cellular extravasation relationship: regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002692 name: negative regulation of cellular extravasation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "down regulation of cellular extravasation" EXACT [] synonym: "down-regulation of cellular extravasation" EXACT [] synonym: "downregulation of cellular extravasation" EXACT [] synonym: "inhibition of cellular extravasation" NARROW [] is_a: GO:0002686 ! negative regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045123 ! cellular extravasation relationship: negatively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002693 name: positive regulation of cellular extravasation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cellular extravasation." [GOC:add] synonym: "activation of cellular extravasation" NARROW [] synonym: "stimulation of cellular extravasation" NARROW [] synonym: "up regulation of cellular extravasation" EXACT [] synonym: "up-regulation of cellular extravasation" EXACT [] synonym: "upregulation of cellular extravasation" EXACT [] is_a: GO:0002687 ! positive regulation of leukocyte migration is_a: GO:0002691 ! regulation of cellular extravasation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045123 ! cellular extravasation relationship: positively_regulates GO:0045123 ! cellular extravasation [Term] id: GO:0002694 name: regulation of leukocyte activation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "regulation of immune cell activation" EXACT [] synonym: "regulation of leucocyte activation" EXACT [] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0050865 ! regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045321 ! leukocyte activation relationship: regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002695 name: negative regulation of leukocyte activation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "down regulation of leukocyte activation" EXACT [] synonym: "down-regulation of leukocyte activation" EXACT [] synonym: "downregulation of leukocyte activation" EXACT [] synonym: "inhibition of leukocyte activation" NARROW [] synonym: "negative regulation of immune cell activation" EXACT [] synonym: "negative regulation of leucocyte activation" EXACT [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050866 ! negative regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045321 ! leukocyte activation relationship: negatively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002696 name: positive regulation of leukocyte activation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte activation." [GOC:add] synonym: "activation of leukocyte activation" NARROW [] synonym: "positive regulation of immune cell activation" EXACT [] synonym: "positive regulation of leucocyte activation" EXACT [] synonym: "stimulation of leukocyte activation" NARROW [] synonym: "up regulation of leukocyte activation" EXACT [] synonym: "up-regulation of leukocyte activation" EXACT [] synonym: "upregulation of leukocyte activation" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002694 ! regulation of leukocyte activation is_a: GO:0050867 ! positive regulation of cell activation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045321 ! leukocyte activation relationship: positively_regulates GO:0045321 ! leukocyte activation [Term] id: GO:0002697 name: regulation of immune effector process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune effector process." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002252 ! immune effector process relationship: regulates GO:0002252 ! immune effector process [Term] id: GO:0002698 name: negative regulation of immune effector process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "down regulation of immune effector process" EXACT [] synonym: "down-regulation of immune effector process" EXACT [] synonym: "downregulation of immune effector process" EXACT [] synonym: "inhibition of immune effector process" NARROW [] is_a: GO:0002683 ! negative regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002252 ! immune effector process relationship: negatively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002699 name: positive regulation of immune effector process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune effector process." [GOC:add] synonym: "activation of immune effector process" NARROW [] synonym: "stimulation of immune effector process" NARROW [] synonym: "up regulation of immune effector process" EXACT [] synonym: "up-regulation of immune effector process" EXACT [] synonym: "upregulation of immune effector process" EXACT [] is_a: GO:0002684 ! positive regulation of immune system process is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002252 ! immune effector process relationship: positively_regulates GO:0002252 ! immune effector process [Term] id: GO:0002700 name: regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002440 ! production of molecular mediator of immune response relationship: regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002701 name: negative regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "down regulation of production of molecular mediator of immune response" EXACT [] synonym: "down-regulation of production of molecular mediator of immune response" EXACT [] synonym: "downregulation of production of molecular mediator of immune response" EXACT [] synonym: "inhibition of production of molecular mediator of immune response" NARROW [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002440 ! production of molecular mediator of immune response relationship: negatively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002702 name: positive regulation of production of molecular mediator of immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of the production of molecular mediator of immune response." [GOC:add] synonym: "activation of production of molecular mediator of immune response" NARROW [] synonym: "stimulation of production of molecular mediator of immune response" NARROW [] synonym: "up regulation of production of molecular mediator of immune response" EXACT [] synonym: "up-regulation of production of molecular mediator of immune response" EXACT [] synonym: "upregulation of production of molecular mediator of immune response" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002440 ! production of molecular mediator of immune response relationship: positively_regulates GO:0002440 ! production of molecular mediator of immune response [Term] id: GO:0002703 name: regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "regulation of immune cell mediated immunity" EXACT [] synonym: "regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002697 ! regulation of immune effector process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002443 ! leukocyte mediated immunity relationship: regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002704 name: negative regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "down regulation of leukocyte mediated immunity" EXACT [] synonym: "down-regulation of leukocyte mediated immunity" EXACT [] synonym: "downregulation of leukocyte mediated immunity" EXACT [] synonym: "inhibition of leukocyte mediated immunity" NARROW [] synonym: "negative regulation of immune cell mediated immunity" EXACT [] synonym: "negative regulation of leucocyte mediated immunity" EXACT [] is_a: GO:0002698 ! negative regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002443 ! leukocyte mediated immunity relationship: negatively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002705 name: positive regulation of leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of leukocyte mediated immunity." [GOC:add] synonym: "activation of leukocyte mediated immunity" NARROW [] synonym: "positive regulation of immune cell mediated immunity" EXACT [] synonym: "positive regulation of leucocyte mediated immunity" EXACT [] synonym: "stimulation of leukocyte mediated immunity" NARROW [] synonym: "up regulation of leukocyte mediated immunity" EXACT [] synonym: "up-regulation of leukocyte mediated immunity" EXACT [] synonym: "upregulation of leukocyte mediated immunity" EXACT [] is_a: GO:0002699 ! positive regulation of immune effector process is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002443 ! leukocyte mediated immunity relationship: positively_regulates GO:0002443 ! leukocyte mediated immunity [Term] id: GO:0002706 name: regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002449 ! lymphocyte mediated immunity relationship: regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002707 name: negative regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "down regulation of lymphocyte mediated immunity" EXACT [] synonym: "down-regulation of lymphocyte mediated immunity" EXACT [] synonym: "downregulation of lymphocyte mediated immunity" EXACT [] synonym: "inhibition of lymphocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: negatively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002708 name: positive regulation of lymphocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte mediated immunity." [GOC:add] synonym: "activation of lymphocyte mediated immunity" NARROW [] synonym: "stimulation of lymphocyte mediated immunity" NARROW [] synonym: "up regulation of lymphocyte mediated immunity" EXACT [] synonym: "up-regulation of lymphocyte mediated immunity" EXACT [] synonym: "upregulation of lymphocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002706 ! regulation of lymphocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002449 ! lymphocyte mediated immunity relationship: positively_regulates GO:0002449 ! lymphocyte mediated immunity [Term] id: GO:0002709 name: regulation of T cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "regulation of T lymphocyte mediated immunity" EXACT [] synonym: "regulation of T-cell mediated immunity" EXACT [] synonym: "regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002456 ! T cell mediated immunity relationship: regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002710 name: negative regulation of T cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "down regulation of T cell mediated immunity" EXACT [] synonym: "down-regulation of T cell mediated immunity" EXACT [] synonym: "downregulation of T cell mediated immunity" EXACT [] synonym: "inhibition of T cell mediated immunity" NARROW [] synonym: "negative regulation of T lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of T-cell mediated immunity" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002456 ! T cell mediated immunity relationship: negatively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002711 name: positive regulation of T cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated immunity." [GOC:add] synonym: "activation of T cell mediated immunity" NARROW [] synonym: "positive regulation of T lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of T-cell mediated immunity" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of T cell mediated immunity" NARROW [] synonym: "up regulation of T cell mediated immunity" EXACT [] synonym: "up-regulation of T cell mediated immunity" EXACT [] synonym: "upregulation of T cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002456 ! T cell mediated immunity relationship: positively_regulates GO:0002456 ! T cell mediated immunity [Term] id: GO:0002712 name: regulation of B cell mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "regulation of B lymphocyte mediated immunity" EXACT [] synonym: "regulation of B-cell mediated immunity" EXACT [] synonym: "regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019724 ! B cell mediated immunity relationship: regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002713 name: negative regulation of B cell mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "down regulation of B cell mediated immunity" EXACT [] synonym: "down-regulation of B cell mediated immunity" EXACT [] synonym: "downregulation of B cell mediated immunity" EXACT [] synonym: "inhibition of B cell mediated immunity" NARROW [] synonym: "negative regulation of B lymphocyte mediated immunity" EXACT [] synonym: "negative regulation of B-cell mediated immunity" EXACT [] synonym: "negative regulation of B-lymphocyte mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019724 ! B cell mediated immunity relationship: negatively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002714 name: positive regulation of B cell mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell mediated immunity." [GOC:add] synonym: "activation of B cell mediated immunity" NARROW [] synonym: "positive regulation of B lymphocyte mediated immunity" EXACT [] synonym: "positive regulation of B-cell mediated immunity" EXACT [] synonym: "positive regulation of B-lymphocyte mediated immunity" EXACT [] synonym: "stimulation of B cell mediated immunity" NARROW [] synonym: "up regulation of B cell mediated immunity" EXACT [] synonym: "up-regulation of B cell mediated immunity" EXACT [] synonym: "upregulation of B cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019724 ! B cell mediated immunity relationship: positively_regulates GO:0019724 ! B cell mediated immunity [Term] id: GO:0002715 name: regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045845 def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "regulation of natural killer cell activity" RELATED [] synonym: "regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002706 ! regulation of lymphocyte mediated immunity is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002228 ! natural killer cell mediated immunity relationship: regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002716 name: negative regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0030102 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "down regulation of natural killer cell mediated immunity" EXACT [] synonym: "down-regulation of natural killer cell mediated immunity" EXACT [] synonym: "downregulation of natural killer cell mediated immunity" EXACT [] synonym: "inhibition of natural killer cell mediated immunity" NARROW [] synonym: "negative regulation of natural killer cell activity" RELATED [] synonym: "negative regulation of NK cell activity" RELATED [] synonym: "negative regulation of NK cell mediated immunity" EXACT [] is_a: GO:0002707 ! negative regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002228 ! natural killer cell mediated immunity relationship: negatively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002717 name: positive regulation of natural killer cell mediated immunity namespace: biological_process alt_id: GO:0045846 def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immunity." [GOC:add] synonym: "activation of natural killer cell mediated immunity" NARROW [] synonym: "positive regulation of natural killer cell activity" RELATED [] synonym: "positive regulation of NK cell activity" RELATED [] synonym: "positive regulation of NK cell mediated immunity" EXACT [] synonym: "stimulation of natural killer cell mediated immunity" NARROW [] synonym: "up regulation of natural killer cell mediated immunity" EXACT [] synonym: "up-regulation of natural killer cell mediated immunity" EXACT [] synonym: "upregulation of natural killer cell mediated immunity" EXACT [] is_a: GO:0002708 ! positive regulation of lymphocyte mediated immunity is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0045089 ! positive regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002228 ! natural killer cell mediated immunity relationship: positively_regulates GO:0002228 ! natural killer cell mediated immunity [Term] id: GO:0002718 name: regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001817 ! regulation of cytokine production is_a: GO:0002700 ! regulation of production of molecular mediator of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002367 ! cytokine production involved in immune response relationship: regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002719 name: negative regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine production contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine production during immune response" RELATED [] synonym: "down-regulation of cytokine production during immune response" EXACT [] synonym: "downregulation of cytokine production during immune response" RELATED [] synonym: "inhibition of cytokine production during immune response" RELATED [] synonym: "negative regulation of cytokine production during immune response" RELATED [GOC:dph] is_a: GO:0001818 ! negative regulation of cytokine production is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002367 ! cytokine production involved in immune response relationship: negatively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002720 name: positive regulation of cytokine production involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine production that contributes to an immune response." [GOC:add] synonym: "activation of cytokine production during immune response" NARROW [] synonym: "positive regulation of cytokine production during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine production during immune response" NARROW [] synonym: "up regulation of cytokine production during immune response" RELATED [] synonym: "up-regulation of cytokine production during immune response" RELATED [] synonym: "upregulation of cytokine production during immune response" RELATED [] is_a: GO:0001819 ! positive regulation of cytokine production is_a: GO:0002702 ! positive regulation of production of molecular mediator of immune response is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002367 ! cytokine production involved in immune response relationship: positively_regulates GO:0002367 ! cytokine production involved in immune response [Term] id: GO:0002721 name: regulation of B cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "regulation of B lymphocyte cytokine production" EXACT [] synonym: "regulation of B-cell cytokine production" EXACT [] synonym: "regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002368 ! B cell cytokine production relationship: regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002722 name: negative regulation of B cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "down regulation of B cell cytokine production" EXACT [] synonym: "down-regulation of B cell cytokine production" EXACT [] synonym: "downregulation of B cell cytokine production" EXACT [] synonym: "inhibition of B cell cytokine production" NARROW [] synonym: "negative regulation of B lymphocyte cytokine production" EXACT [] synonym: "negative regulation of B-cell cytokine production" EXACT [] synonym: "negative regulation of B-lymphocyte cytokine production" EXACT [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002368 ! B cell cytokine production relationship: negatively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002723 name: positive regulation of B cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell cytokine production." [GOC:add] synonym: "activation of B cell cytokine production" NARROW [] synonym: "positive regulation of B lymphocyte cytokine production" EXACT [] synonym: "positive regulation of B-cell cytokine production" EXACT [] synonym: "positive regulation of B-lymphocyte cytokine production" EXACT [] synonym: "stimulation of B cell cytokine production" NARROW [] synonym: "up regulation of B cell cytokine production" EXACT [] synonym: "up-regulation of B cell cytokine production" EXACT [] synonym: "upregulation of B cell cytokine production" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002721 ! regulation of B cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002368 ! B cell cytokine production relationship: positively_regulates GO:0002368 ! B cell cytokine production [Term] id: GO:0002724 name: regulation of T cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "regulation of T lymphocyte cytokine production" EXACT [] synonym: "regulation of T-cell cytokine production" EXACT [] synonym: "regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002369 ! T cell cytokine production relationship: regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002725 name: negative regulation of T cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "down regulation of T cell cytokine production" EXACT [] synonym: "down-regulation of T cell cytokine production" EXACT [] synonym: "downregulation of T cell cytokine production" EXACT [] synonym: "inhibition of T cell cytokine production" NARROW [] synonym: "negative regulation of T lymphocyte cytokine production" EXACT [] synonym: "negative regulation of T-cell cytokine production" EXACT [] synonym: "negative regulation of T-lymphocyte cytokine production" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002369 ! T cell cytokine production relationship: negatively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002726 name: positive regulation of T cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell cytokine production." [GOC:add] synonym: "activation of T cell cytokine production" NARROW [] synonym: "positive regulation of T lymphocyte cytokine production" EXACT [] synonym: "positive regulation of T-cell cytokine production" EXACT [] synonym: "positive regulation of T-lymphocyte cytokine production" EXACT [] synonym: "stimulation of T cell cytokine production" NARROW [] synonym: "up regulation of T cell cytokine production" EXACT [] synonym: "up-regulation of T cell cytokine production" EXACT [] synonym: "upregulation of T cell cytokine production" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002724 ! regulation of T cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002369 ! T cell cytokine production relationship: positively_regulates GO:0002369 ! T cell cytokine production [Term] id: GO:0002727 name: regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "regulation of NK cell cytokine production" EXACT [] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002370 ! natural killer cell cytokine production relationship: regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002728 name: negative regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "down regulation of natural killer cell cytokine production" EXACT [] synonym: "down-regulation of natural killer cell cytokine production" EXACT [] synonym: "downregulation of natural killer cell cytokine production" EXACT [] synonym: "inhibition of natural killer cell cytokine production" NARROW [] synonym: "negative regulation of NK cell cytokine production" EXACT [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002370 ! natural killer cell cytokine production relationship: negatively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002729 name: positive regulation of natural killer cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell cytokine production." [GOC:add] synonym: "activation of natural killer cell cytokine production" NARROW [] synonym: "positive regulation of NK cell cytokine production" EXACT [] synonym: "stimulation of natural killer cell cytokine production" NARROW [] synonym: "up regulation of natural killer cell cytokine production" EXACT [] synonym: "up-regulation of natural killer cell cytokine production" EXACT [] synonym: "upregulation of natural killer cell cytokine production" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002727 ! regulation of natural killer cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002370 ! natural killer cell cytokine production relationship: positively_regulates GO:0002370 ! natural killer cell cytokine production [Term] id: GO:0002730 name: regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] is_a: GO:0002718 ! regulation of cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002371 ! dendritic cell cytokine production relationship: regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002731 name: negative regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "down regulation of dendritic cell cytokine production" EXACT [] synonym: "down-regulation of dendritic cell cytokine production" EXACT [] synonym: "downregulation of dendritic cell cytokine production" EXACT [] synonym: "inhibition of dendritic cell cytokine production" NARROW [] is_a: GO:0002719 ! negative regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002371 ! dendritic cell cytokine production relationship: negatively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002732 name: positive regulation of dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of dendritic cell cytokine production." [GOC:add] synonym: "activation of dendritic cell cytokine production" NARROW [] synonym: "stimulation of dendritic cell cytokine production" NARROW [] synonym: "up regulation of dendritic cell cytokine production" EXACT [] synonym: "up-regulation of dendritic cell cytokine production" EXACT [] synonym: "upregulation of dendritic cell cytokine production" EXACT [] is_a: GO:0002720 ! positive regulation of cytokine production involved in immune response is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002371 ! dendritic cell cytokine production relationship: positively_regulates GO:0002371 ! dendritic cell cytokine production [Term] id: GO:0002733 name: regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002734 name: negative regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "downregulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "inhibition of myeloid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: negatively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002735 name: positive regulation of myeloid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid dendritic cell cytokine production." [GOC:add] synonym: "activation of myeloid dendritic cell cytokine production" NARROW [] synonym: "stimulation of myeloid dendritic cell cytokine production" NARROW [] synonym: "up regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of myeloid dendritic cell cytokine production" EXACT [] synonym: "upregulation of myeloid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002733 ! regulation of myeloid dendritic cell cytokine production is_a: GO:0061081 ! positive regulation of myeloid leukocyte cytokine production involved in immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production relationship: positively_regulates GO:0002372 ! myeloid dendritic cell cytokine production [Term] id: GO:0002736 name: regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] is_a: GO:0002730 ! regulation of dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002737 name: negative regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "down regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "down-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "downregulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "inhibition of plasmacytoid dendritic cell cytokine production" NARROW [] is_a: GO:0002731 ! negative regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: negatively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002738 name: positive regulation of plasmacytoid dendritic cell cytokine production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of plasmacytoid dendritic cell cytokine production." [GOC:add] synonym: "activation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "stimulation of plasmacytoid dendritic cell cytokine production" NARROW [] synonym: "up regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "up-regulation of plasmacytoid dendritic cell cytokine production" EXACT [] synonym: "upregulation of plasmacytoid dendritic cell cytokine production" EXACT [] is_a: GO:0002732 ! positive regulation of dendritic cell cytokine production is_a: GO:0002736 ! regulation of plasmacytoid dendritic cell cytokine production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production relationship: positively_regulates GO:0002373 ! plasmacytoid dendritic cell cytokine production [Term] id: GO:0002739 name: regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0050707 ! regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002374 ! cytokine secretion involved in immune response relationship: regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002740 name: negative regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine secretion during immune response" RELATED [] synonym: "down-regulation of cytokine secretion during immune response" RELATED [] synonym: "downregulation of cytokine secretion during immune response" RELATED [] synonym: "inhibition of cytokine secretion during immune response" NARROW [] synonym: "negative regulation of cytokine secretion during immune response" RELATED [GOC:dph] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050710 ! negative regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response relationship: negatively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002741 name: positive regulation of cytokine secretion involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine secretion contributing to an immune response." [GOC:add] synonym: "activation of cytokine secretion during immune response" NARROW [] synonym: "positive regulation of cytokine secretion during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine secretion during immune response" NARROW [] synonym: "up regulation of cytokine secretion during immune response" RELATED [] synonym: "up-regulation of cytokine secretion during immune response" RELATED [] synonym: "upregulation of cytokine secretion during immune response" RELATED [] is_a: GO:0002739 ! regulation of cytokine secretion involved in immune response is_a: GO:0050715 ! positive regulation of cytokine secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002374 ! cytokine secretion involved in immune response relationship: positively_regulates GO:0002374 ! cytokine secretion involved in immune response [Term] id: GO:0002742 name: regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of cytokine biosynthesis that contributes to an immune response." [GOC:add] synonym: "regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002718 ! regulation of cytokine production involved in immune response is_a: GO:0042035 ! regulation of cytokine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002743 name: negative regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "down regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "down-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "downregulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "inhibition of cytokine biosynthetic process during immune response" NARROW [] synonym: "negative regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042036 ! negative regulation of cytokine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: negatively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002744 name: positive regulation of cytokine biosynthetic process involved in immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of cytokine biosynthesis contributing to an immune response." [GOC:add] synonym: "activation of cytokine biosynthetic process during immune response" NARROW [] synonym: "positive regulation of cytokine biosynthetic process during immune response" RELATED [GOC:dph] synonym: "stimulation of cytokine biosynthetic process during immune response" NARROW [] synonym: "up regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "up-regulation of cytokine biosynthetic process during immune response" RELATED [] synonym: "upregulation of cytokine biosynthetic process during immune response" RELATED [] is_a: GO:0002742 ! regulation of cytokine biosynthetic process involved in immune response is_a: GO:0042108 ! positive regulation of cytokine biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response relationship: positively_regulates GO:0002375 ! cytokine biosynthetic process involved in immune response [Term] id: GO:0002745 name: antigen processing and presentation initiated by receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface receptor." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002746 name: antigen processing and presentation following pinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via pinocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002747 name: antigen processing and presentation following phagocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via phagocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0019882 ! antigen processing and presentation [Term] id: GO:0002748 name: antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen bound to a cell surface pattern recognition receptor (PRR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "antigen processing and presentation initiated by PAMP receptor mediated uptake of antigen" EXACT [] synonym: "antigen processing and presentation initiated by PRR mediated uptake of antigen" EXACT [] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002749 name: antigen processing and presentation initiated by toll-like receptor mediated phagocytosis of antigen namespace: biological_process def: "Antigen processing and presentation which is initiated by phagocytosis of antigen bound directly or indirectly to a cell surface toll-like receptor (TLR)." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15596122] synonym: "antigen processing and presentation initiated by TLR mediated phagocytosis of antigen" EXACT [] is_a: GO:0002747 ! antigen processing and presentation following phagocytosis is_a: GO:0002748 ! antigen processing and presentation initiated by pattern recognition receptor mediated uptake of antigen [Term] id: GO:0002750 name: antigen processing and presentation following macropinocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen via macropinocytosis." [GOC:add, PMID:16556257] is_a: GO:0002746 ! antigen processing and presentation following pinocytosis [Term] id: GO:0002751 name: antigen processing and presentation following receptor mediated endocytosis namespace: biological_process def: "Antigen processing and presentation which is initiated by uptake of antigen receptor-mediated endocytosis." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002745 ! antigen processing and presentation initiated by receptor mediated uptake of antigen [Term] id: GO:0002752 name: cell surface pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a cell surface pattern recognition receptor (PRR). Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "cell surface PAMP receptor signaling pathway" EXACT [] synonym: "cell surface pathogen receptor signaling pathway" EXACT [] synonym: "cell surface pattern recognition receptor signalling pathway" EXACT [] synonym: "cell surface PRR signaling pathway" EXACT [] is_a: GO:0002220 ! innate immune response activating cell surface receptor signaling pathway is_a: GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0002753 name: cytoplasmic pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located in the cytoplasm. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "cytoplasmic PAMP receptor signaling pathway" EXACT [] synonym: "cytoplasmic pathogen receptor signaling pathway" EXACT [] synonym: "cytoplasmic pattern recognition receptor signalling pathway" EXACT [] synonym: "cytoplasmic PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0002754 name: intracellular vesicle pattern recognition receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a pattern recognition receptor (PRR) located within the membrane of an intracellular vesicle such as an endosome or lysosome. Such receptors bind for molecular patterns based on a repeating or polymeric structures, like those of polysaccharides or peptidoglycans, which are sometimes associated with potential pathogens." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15199967] synonym: "intracellular vesicle PAMP receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pathogen receptor signaling pathway" EXACT [] synonym: "intracellular vesicle pattern recognition receptor signalling pathway" EXACT [] synonym: "intracellular vesicle PRR signaling pathway" EXACT [] is_a: GO:0002221 ! pattern recognition receptor signaling pathway is_a: GO:0030522 ! intracellular receptor mediated signaling pathway [Term] id: GO:0002755 name: MyD88-dependent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor and relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-dependent TLR signaling pathway" EXACT [] synonym: "MyD88-dependent toll-like receptor signalling pathway" EXACT [] is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002756 name: MyD88-independent toll-like receptor signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of binding to a toll-like receptor not relying on the MyD88 adaptor molecule. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:12467241, PMID:12524386, PMID:12855817, PMID:15585605, PMID:15728447] synonym: "MyD88-independent TLR signaling pathway" EXACT [] synonym: "MyD88-independent toll-like receptor signalling pathway" EXACT [] xref: Reactome:168180 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:168927 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:168936 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:562680 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:563119 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:563328 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:588305 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:588731 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:588943 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:609045 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:609467 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:609707 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:633738 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:634168 "Viral dsRNA:TLR3:TRIF Complex Activates TBK1/IKK epsilon" xref: Reactome:634358 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:645351 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:645824 "Viral dsRNA:TLR3:TRIF Complex Activates RIP1" xref: Reactome:655721 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:661193 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:666971 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:673106 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:678806 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:683734 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:689951 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:701726 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:716303 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:728246 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" xref: Reactome:731082 "TRAF6 Mediated Induction of the antiviral cytokine IFN-alpha/beta cascade" is_a: GO:0002224 ! toll-like receptor signaling pathway [Term] id: GO:0002757 name: immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an immune response." [GOC:add] is_a: GO:0002253 ! activation of immune response is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002758 name: innate immune response-activating signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to activation or perpetuation of an innate immune response." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was added by GO_REF:0000022. is_a: GO:0002218 ! activation of innate immune response is_a: GO:0002757 ! immune response-activating signal transduction [Term] id: GO:0002759 name: regulation of antimicrobial humoral response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0043900 ! regulation of multi-organism process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019730 ! antimicrobial humoral response relationship: regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002760 name: positive regulation of antimicrobial humoral response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an antimicrobial humoral response." [GOC:add] synonym: "activation of antimicrobial humoral response" NARROW [] synonym: "stimulation of antimicrobial humoral response" NARROW [] synonym: "up regulation of antimicrobial humoral response" EXACT [] synonym: "up-regulation of antimicrobial humoral response" EXACT [] synonym: "upregulation of antimicrobial humoral response" EXACT [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0043902 ! positive regulation of multi-organism process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0019730 ! antimicrobial humoral response relationship: positively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002761 name: regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] is_a: GO:0045637 ! regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002573 ! myeloid leukocyte differentiation relationship: regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002762 name: negative regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "down regulation of myeloid leukocyte differentiation" EXACT [] synonym: "down-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "downregulation of myeloid leukocyte differentiation" EXACT [] synonym: "inhibition of myeloid leukocyte differentiation" NARROW [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045638 ! negative regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: negatively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002763 name: positive regulation of myeloid leukocyte differentiation namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte differentiation." [GOC:add] synonym: "activation of myeloid leukocyte differentiation" NARROW [] synonym: "stimulation of myeloid leukocyte differentiation" NARROW [] synonym: "up regulation of myeloid leukocyte differentiation" EXACT [] synonym: "up-regulation of myeloid leukocyte differentiation" EXACT [] synonym: "upregulation of myeloid leukocyte differentiation" EXACT [] is_a: GO:0002761 ! regulation of myeloid leukocyte differentiation is_a: GO:0045639 ! positive regulation of myeloid cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002573 ! myeloid leukocyte differentiation relationship: positively_regulates GO:0002573 ! myeloid leukocyte differentiation [Term] id: GO:0002764 name: immune response-regulating signaling pathway namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to the activation, perpetuation, or inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] is_a: GO:0023033 ! signaling pathway is_a: GO:0050776 ! regulation of immune response [Term] id: GO:0002765 name: immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0002764 ! immune response-regulating signaling pathway [Term] id: GO:0002766 name: innate immune response-inhibiting signal transduction namespace: biological_process def: "The cascade of processes by which a signal interacts with a receptor, causing a change in the level or activity of a second messenger or other downstream target, and ultimately leading to inhibition of an innate immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] is_a: GO:0002765 ! immune response-inhibiting signal transduction [Term] id: GO:0002767 name: immune response-inhibiting cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "immune response-inhibiting cell surface receptor signalling pathway" EXACT [] is_a: GO:0002765 ! immune response-inhibiting signal transduction is_a: GO:0002768 ! immune response-regulating cell surface receptor signaling pathway [Term] id: GO:0002768 name: immune response-regulating cell surface receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell capable of activating, perpetuating, or inhibiting an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "immune response-regulating cell surface receptor signalling pathway" EXACT [] is_a: GO:0002764 ! immune response-regulating signaling pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0002769 name: natural killer cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a natural killer cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory KIR signaling pathway" NARROW [] synonym: "killer cell inhibitory receptor signaling pathway" NARROW [] synonym: "Ly49 inhibitory receptor signaling pathway" NARROW [] synonym: "natural killer cell inhibitory signalling pathway" EXACT [] synonym: "NK cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002770 name: T cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a T cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:15258309] synonym: "T cell inhibitory signalling pathway" EXACT [] synonym: "T lymphocyte inhibitory signaling pathway" EXACT [] synonym: "T-cell inhibitory signaling pathway" EXACT [] synonym: "T-lymphocyte inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002771 name: inhibitory killer cell immunoglobulin-like receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a inhibitory killer cell immunoglobulin-like receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory killer cell immunoglobulin-like receptor signalling pathway" EXACT [] synonym: "killer cell inhibitory receptor signaling pathway" EXACT [] synonym: "KIR signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002772 name: inhibitory C-type lectin receptor signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to an inhibitory C-type lectin receptor capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:15771571] synonym: "inhibitory C-type lectin receptor signalling pathway" EXACT [] synonym: "Ly49 inhibitory receptor signaling pathway" NARROW [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002773 name: B cell inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of a B cell capable of inhibiting an immune effector process contributing to an immune response." [GOC:add, PMID:16413920] synonym: "B cell inhibitory signalling pathway" EXACT [] synonym: "B lymphocyte inhibitory signaling pathwayBT-lymphocyte inhibitory signaling pathway" EXACT [] synonym: "B-cell inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002774 name: Fc receptor mediated inhibitory signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of a the binding of the Fc portion of an immunoglobulin by an Fc receptor capable of inhibiting an immune effector process contributing to an immune response. The Fc portion of an immunoglobulin is its C-terminal constant region." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "Fc receptor mediated inhibitory signalling pathway" EXACT [] synonym: "Fc-receptor mediated inhibitory signaling pathway" EXACT [] is_a: GO:0002767 ! immune response-inhibiting cell surface receptor signaling pathway [Term] id: GO:0002775 name: antimicrobial peptide production namespace: biological_process def: "The synthesis or release of an antimicrobial peptide during an immune response, resulting in an increase in intracellular or extracellular levels. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002440 ! production of molecular mediator of immune response relationship: part_of GO:0019730 ! antimicrobial humoral response [Term] id: GO:0002776 name: antimicrobial peptide secretion namespace: biological_process def: "The regulated release of an antimicrobial peptide from a cell or group of cells. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002790 ! peptide secretion relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002777 name: antimicrobial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antimicrobial peptide. Such peptides may have protective properties against bacteria, fungi, viruses, or protozoa." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0043043 ! peptide biosynthetic process relationship: part_of GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002778 name: antibacterial peptide production namespace: biological_process def: "The synthesis or release of an antibacterial peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019731 ! antibacterial humoral response [Term] id: GO:0002779 name: antibacterial peptide secretion namespace: biological_process def: "The regulated release of an antibacterial peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002780 name: antibacterial peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002778 ! antibacterial peptide production [Term] id: GO:0002781 name: antifungal peptide production namespace: biological_process def: "The synthesis or release of an antifungal peptide during an immune response, resulting in an increase in intracellular or extracellular levels." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002775 ! antimicrobial peptide production relationship: part_of GO:0019732 ! antifungal humoral response [Term] id: GO:0002782 name: antifungal peptide secretion namespace: biological_process def: "The regulated release of an antifungal peptide from a cell or group of cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002776 ! antimicrobial peptide secretion relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002783 name: antifungal peptide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antifungal peptide." [GOC:add, ISBN:0781735149 "Fundamental Immunology", PMID:11807545, PMID:15638771] is_a: GO:0002777 ! antimicrobial peptide biosynthetic process relationship: part_of GO:0002781 ! antifungal peptide production [Term] id: GO:0002784 name: regulation of antimicrobial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] is_a: GO:0002700 ! regulation of production of molecular mediator of immune response is_a: GO:0002759 ! regulation of antimicrobial humoral response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002775 ! antimicrobial peptide production relationship: regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002785 name: negative regulation of antimicrobial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide production." [GOC:add] synonym: "down regulation of antimicrobial peptide production" EXACT [] synonym: "down-regulation of antimicrobial peptide production" EXACT [] synonym: "downregulation of antimicrobial peptide production" EXACT [] synonym: "inhibition of antimicrobial peptide production" NARROW [] is_a: GO:0002701 ! negative regulation of production of molecular mediator of immune response is_a: GO:0002784 ! regulation of antimicrobial peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002775 ! antimicrobial peptide production relationship: negatively_regulates GO:0002775 ! antimicrobial peptide production [Term] id: GO:0002786 name: regulation of antibacterial peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002778 ! antibacterial peptide production relationship: regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002787 name: negative regulation of antibacterial peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "down regulation of antibacterial peptide production" EXACT [] synonym: "down-regulation of antibacterial peptide production" EXACT [] synonym: "downregulation of antibacterial peptide production" EXACT [] synonym: "inhibition of antibacterial peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002778 ! antibacterial peptide production relationship: negatively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002788 name: regulation of antifungal peptide production namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide production." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002781 ! antifungal peptide production relationship: regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002789 name: negative regulation of antifungal peptide production namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "down regulation of antifungal peptide production" EXACT [] synonym: "down-regulation of antifungal peptide production" EXACT [] synonym: "downregulation of antifungal peptide production" EXACT [] synonym: "inhibition of antifungal peptide production" NARROW [] is_a: GO:0002785 ! negative regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002781 ! antifungal peptide production relationship: negatively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002790 name: peptide secretion namespace: biological_process def: "The controlled release of a peptide from a cell or group of cells." [GOC:add] is_a: GO:0015833 ! peptide transport is_a: GO:0046903 ! secretion [Term] id: GO:0002791 name: regulation of peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peptide secretion." [GOC:add] is_a: GO:0051046 ! regulation of secretion is_a: GO:0090087 ! regulation of peptide transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002790 ! peptide secretion relationship: regulates GO:0002790 ! peptide secretion [Term] id: GO:0002792 name: negative regulation of peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "down regulation of peptide secretion" EXACT [] synonym: "down-regulation of peptide secretion" EXACT [] synonym: "downregulation of peptide secretion" EXACT [] synonym: "inhibition of peptide secretion" NARROW [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002790 ! peptide secretion relationship: negatively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002793 name: positive regulation of peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peptide secretion." [GOC:add] synonym: "activation of peptide secretion" NARROW [] synonym: "stimulation of peptide secretion" NARROW [] synonym: "up regulation of peptide secretion" EXACT [] synonym: "up-regulation of peptide secretion" EXACT [] synonym: "upregulation of peptide secretion" EXACT [] is_a: GO:0002791 ! regulation of peptide secretion is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002790 ! peptide secretion relationship: positively_regulates GO:0002790 ! peptide secretion [Term] id: GO:0002794 name: regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0002791 ! regulation of peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002776 ! antimicrobial peptide secretion relationship: regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002795 name: negative regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "down regulation of antimicrobial peptide secretion" EXACT [] synonym: "down-regulation of antimicrobial peptide secretion" EXACT [] synonym: "downregulation of antimicrobial peptide secretion" EXACT [] synonym: "inhibition of antimicrobial peptide secretion" NARROW [] is_a: GO:0002792 ! negative regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002776 ! antimicrobial peptide secretion relationship: negatively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002796 name: positive regulation of antimicrobial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide secretion." [GOC:add] synonym: "activation of antimicrobial peptide secretion" NARROW [] synonym: "stimulation of antimicrobial peptide secretion" NARROW [] synonym: "up regulation of antimicrobial peptide secretion" EXACT [] synonym: "up-regulation of antimicrobial peptide secretion" EXACT [] synonym: "upregulation of antimicrobial peptide secretion" EXACT [] is_a: GO:0002793 ! positive regulation of peptide secretion is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002776 ! antimicrobial peptide secretion relationship: positively_regulates GO:0002776 ! antimicrobial peptide secretion [Term] id: GO:0002797 name: regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002779 ! antibacterial peptide secretion relationship: regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002798 name: negative regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "down regulation of antibacterial peptide secretion" EXACT [] synonym: "down-regulation of antibacterial peptide secretion" EXACT [] synonym: "downregulation of antibacterial peptide secretion" EXACT [] synonym: "inhibition of antibacterial peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002779 ! antibacterial peptide secretion relationship: negatively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002799 name: positive regulation of antibacterial peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide secretion." [GOC:add] synonym: "activation of antibacterial peptide secretion" NARROW [] synonym: "stimulation of antibacterial peptide secretion" NARROW [] synonym: "up regulation of antibacterial peptide secretion" EXACT [] synonym: "up-regulation of antibacterial peptide secretion" EXACT [] synonym: "upregulation of antibacterial peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002797 ! regulation of antibacterial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002779 ! antibacterial peptide secretion relationship: positively_regulates GO:0002779 ! antibacterial peptide secretion [Term] id: GO:0002800 name: regulation of antifungal peptide secretion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002794 ! regulation of antimicrobial peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002782 ! antifungal peptide secretion relationship: regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002801 name: negative regulation of antifungal peptide secretion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "down regulation of antifungal peptide secretion" EXACT [] synonym: "down-regulation of antifungal peptide secretion" EXACT [] synonym: "downregulation of antifungal peptide secretion" EXACT [] synonym: "inhibition of antifungal peptide secretion" NARROW [] is_a: GO:0002795 ! negative regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002782 ! antifungal peptide secretion relationship: negatively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002802 name: positive regulation of antifungal peptide secretion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide secretion." [GOC:add] synonym: "activation of antifungal peptide secretion" NARROW [] synonym: "stimulation of antifungal peptide secretion" NARROW [] synonym: "up regulation of antifungal peptide secretion" EXACT [] synonym: "up-regulation of antifungal peptide secretion" EXACT [] synonym: "upregulation of antifungal peptide secretion" EXACT [] is_a: GO:0002796 ! positive regulation of antimicrobial peptide secretion is_a: GO:0002800 ! regulation of antifungal peptide secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002782 ! antifungal peptide secretion relationship: positively_regulates GO:0002782 ! antifungal peptide secretion [Term] id: GO:0002803 name: positive regulation of antibacterial peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide production." [GOC:add] synonym: "activation of antibacterial peptide production" NARROW [] synonym: "stimulation of antibacterial peptide production" NARROW [] synonym: "up regulation of antibacterial peptide production" EXACT [] synonym: "up-regulation of antibacterial peptide production" EXACT [] synonym: "upregulation of antibacterial peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002786 ! regulation of antibacterial peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002778 ! antibacterial peptide production relationship: positively_regulates GO:0002778 ! antibacterial peptide production [Term] id: GO:0002804 name: positive regulation of antifungal peptide production namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide production." [GOC:add] synonym: "activation of antifungal peptide production" NARROW [] synonym: "stimulation of antifungal peptide production" NARROW [] synonym: "up regulation of antifungal peptide production" EXACT [] synonym: "up-regulation of antifungal peptide production" EXACT [] synonym: "upregulation of antifungal peptide production" EXACT [] is_a: GO:0002225 ! positive regulation of antimicrobial peptide production is_a: GO:0002788 ! regulation of antifungal peptide production intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002781 ! antifungal peptide production relationship: positively_regulates GO:0002781 ! antifungal peptide production [Term] id: GO:0002805 name: regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] is_a: GO:0002784 ! regulation of antimicrobial peptide production is_a: GO:0031326 ! regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002806 name: negative regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "down regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "downregulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "inhibition of antimicrobial peptide biosynthetic process" NARROW [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: negatively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002807 name: positive regulation of antimicrobial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antimicrobial peptide biosynthesis." [GOC:add] synonym: "activation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "stimulation of antimicrobial peptide biosynthetic process" NARROW [] synonym: "up regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antimicrobial peptide biosynthetic process" EXACT [] synonym: "upregulation of antimicrobial peptide biosynthetic process" EXACT [] is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process relationship: positively_regulates GO:0002777 ! antimicrobial peptide biosynthetic process [Term] id: GO:0002808 name: regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] is_a: GO:0002786 ! regulation of antibacterial peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002809 name: negative regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:add] synonym: "down regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "down-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "downregulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "inhibition of antibacterial peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: negatively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0002810 name: regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] is_a: GO:0002788 ! regulation of antifungal peptide production is_a: GO:0002805 ! regulation of antimicrobial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002811 name: negative regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:add] synonym: "down regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "down-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "downregulation of antifungal peptide biosynthetic process" EXACT [] synonym: "inhibition of antifungal peptide biosynthetic process" NARROW [] is_a: GO:0002806 ! negative regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: negatively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0002812 name: biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-negative bacteria." [GOC:add, PMID:11807545] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050829 ! defense response to Gram-negative bacterium [Term] id: GO:0002813 name: regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002814 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: negatively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0002815 name: biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an antibacterial peptide with activity against Gram-positive bacteria." [GOC:add] is_a: GO:0002780 ! antibacterial peptide biosynthetic process relationship: part_of GO:0050830 ! defense response to Gram-positive bacterium [Term] id: GO:0002816 name: regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002817 name: negative regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:add] synonym: "down regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "down-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "downregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "inhibition of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] is_a: GO:0002809 ! negative regulation of antibacterial peptide biosynthetic process is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: negatively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0002818 name: intracellular defense response namespace: biological_process def: "A physiological defense response which occurs intracellularly." [GOC:add] synonym: "intracellular defence response" EXACT [] is_a: GO:0006968 ! cellular defense response is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0002819 name: regulation of adaptive immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002250 ! adaptive immune response relationship: regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002820 name: negative regulation of adaptive immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "down regulation of adaptive immune response" EXACT [] synonym: "down-regulation of adaptive immune response" EXACT [] synonym: "downregulation of adaptive immune response" EXACT [] synonym: "inhibition of adaptive immune response" NARROW [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002250 ! adaptive immune response relationship: negatively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002821 name: positive regulation of adaptive immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response." [GOC:add] synonym: "activation of adaptive immune response" NARROW [] synonym: "stimulation of adaptive immune response" NARROW [] synonym: "up regulation of adaptive immune response" EXACT [] synonym: "up-regulation of adaptive immune response" EXACT [] synonym: "upregulation of adaptive immune response" EXACT [] is_a: GO:0002819 ! regulation of adaptive immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002250 ! adaptive immune response relationship: positively_regulates GO:0002250 ! adaptive immune response [Term] id: GO:0002822 name: regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002819 ! regulation of adaptive immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002823 name: negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002820 ! negative regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: negatively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002824 name: positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains. An example of this process is found in the Gnathostomata." [GOC:add, GOC:mtg_sensu] is_a: GO:0002821 ! positive regulation of adaptive immune response is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains relationship: positively_regulates GO:0002460 ! adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains [Term] id: GO:0002825 name: regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042088 ! T-helper 1 type immune response relationship: regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002826 name: negative regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "down regulation of T-helper 1 type immune response" EXACT [] synonym: "down-regulation of T-helper 1 type immune response" EXACT [] synonym: "downregulation of T-helper 1 type immune response" EXACT [] synonym: "inhibition of T-helper 1 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042088 ! T-helper 1 type immune response relationship: negatively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002827 name: positive regulation of T-helper 1 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 1 type immune response." [GOC:add] synonym: "activation of T-helper 1 type immune response" NARROW [] synonym: "stimulation of T-helper 1 type immune response" NARROW [] synonym: "up regulation of T-helper 1 type immune response" EXACT [] synonym: "up-regulation of T-helper 1 type immune response" EXACT [] synonym: "upregulation of T-helper 1 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002825 ! regulation of T-helper 1 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042088 ! T-helper 1 type immune response relationship: positively_regulates GO:0042088 ! T-helper 1 type immune response [Term] id: GO:0002828 name: regulation of T-helper 2 type immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] is_a: GO:0002822 ! regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042092 ! T-helper 2 type immune response relationship: regulates GO:0042092 ! T-helper 2 type immune response [Term] id: GO:0002829 name: negative regulation of T-helper 2 type immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] synonym: "down regulation of T-helper 2 type immune response" EXACT [] synonym: "down-regulation of T-helper 2 type immune response" EXACT [] synonym: "downregulation of T-helper 2 type immune response" EXACT [] synonym: "inhibition of T-helper 2 type immune response" NARROW [] is_a: GO:0002823 ! negative regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002828 ! regulation of T-helper 2 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042092 ! T-helper 2 type immune response relationship: negatively_regulates GO:0042092 ! T-helper 2 type immune response [Term] id: GO:0002830 name: positive regulation of T-helper 2 type immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T-helper 2 type immune response." [GOC:add] synonym: "activation of T-helper 2 type immune response" NARROW [] synonym: "stimulation of T-helper 2 type immune response" NARROW [] synonym: "up regulation of T-helper 2 type immune response" EXACT [] synonym: "up-regulation of T-helper 2 type immune response" EXACT [] synonym: "upregulation of T-helper 2 type immune response" EXACT [] is_a: GO:0002824 ! positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains is_a: GO:0002828 ! regulation of T-helper 2 type immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0042092 ! T-helper 2 type immune response relationship: positively_regulates GO:0042092 ! T-helper 2 type immune response [Term] id: GO:0002831 name: regulation of response to biotic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009607 ! response to biotic stimulus relationship: regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002832 name: negative regulation of response to biotic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] synonym: "down regulation of response to biotic stimulus" EXACT [] synonym: "down-regulation of response to biotic stimulus" EXACT [] synonym: "downregulation of response to biotic stimulus" EXACT [] synonym: "inhibition of response to biotic stimulus" NARROW [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009607 ! response to biotic stimulus relationship: negatively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002833 name: positive regulation of response to biotic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to biotic stimulus." [GOC:add] synonym: "activation of response to biotic stimulus" NARROW [] synonym: "stimulation of response to biotic stimulus" NARROW [] synonym: "up regulation of response to biotic stimulus" EXACT [] synonym: "up-regulation of response to biotic stimulus" EXACT [] synonym: "upregulation of response to biotic stimulus" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009607 ! response to biotic stimulus relationship: positively_regulates GO:0009607 ! response to biotic stimulus [Term] id: GO:0002834 name: regulation of response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "regulation of response to tumour cell" EXACT [] is_a: GO:0002831 ! regulation of response to biotic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002347 ! response to tumor cell relationship: regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002835 name: negative regulation of response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "down regulation of response to tumor cell" EXACT [] synonym: "down-regulation of response to tumor cell" EXACT [] synonym: "downregulation of response to tumor cell" EXACT [] synonym: "inhibition of response to tumor cell" NARROW [] synonym: "negative regulation of response to tumour cell" EXACT [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002347 ! response to tumor cell relationship: negatively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002836 name: positive regulation of response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a response to tumor cell." [GOC:add] synonym: "activation of response to tumor cell" NARROW [] synonym: "positive regulation of response to tumour cell" EXACT [] synonym: "stimulation of response to tumor cell" NARROW [] synonym: "up regulation of response to tumor cell" EXACT [] synonym: "up-regulation of response to tumor cell" EXACT [] synonym: "upregulation of response to tumor cell" EXACT [] is_a: GO:0002833 ! positive regulation of response to biotic stimulus is_a: GO:0002834 ! regulation of response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002347 ! response to tumor cell relationship: positively_regulates GO:0002347 ! response to tumor cell [Term] id: GO:0002837 name: regulation of immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "regulation of immune response to tumour cell" EXACT [] is_a: GO:0002834 ! regulation of response to tumor cell is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002418 ! immune response to tumor cell relationship: regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002838 name: negative regulation of immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "down regulation of immune response to tumor cell" EXACT [] synonym: "down-regulation of immune response to tumor cell" EXACT [] synonym: "downregulation of immune response to tumor cell" EXACT [] synonym: "inhibition of immune response to tumor cell" NARROW [] synonym: "negative regulation of immune response to tumour cell" EXACT [] is_a: GO:0002835 ! negative regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002418 ! immune response to tumor cell relationship: negatively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002839 name: positive regulation of immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immune response to tumor cell." [GOC:add] synonym: "activation of immune response to tumor cell" NARROW [] synonym: "positive regulation of immune response to tumour cell" EXACT [] synonym: "stimulation of immune response to tumor cell" NARROW [] synonym: "up regulation of immune response to tumor cell" EXACT [] synonym: "up-regulation of immune response to tumor cell" EXACT [] synonym: "upregulation of immune response to tumor cell" EXACT [] is_a: GO:0002836 ! positive regulation of response to tumor cell is_a: GO:0002837 ! regulation of immune response to tumor cell is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002418 ! immune response to tumor cell relationship: positively_regulates GO:0002418 ! immune response to tumor cell [Term] id: GO:0002840 name: regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002709 ! regulation of T cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002841 name: negative regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "down regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of T cell mediated immune response to tumor cell" NARROW [] synonym: "negative regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "negative regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "negative regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002842 name: positive regulation of T cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a T cell mediated immune response to tumor cell." [GOC:add] synonym: "activation of T cell mediated immune response to tumor cell" NARROW [] synonym: "positive regulation of T cell mediated immune response to tumour cell" EXACT [] synonym: "positive regulation of T lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-cell mediated immune response to tumor cell" EXACT [] synonym: "positive regulation of T-lymphocyte mediated immune response to tumor cell" EXACT [] synonym: "stimulation of T cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of T cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of T cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell relationship: positively_regulates GO:0002424 ! T cell mediated immune response to tumor cell [Term] id: GO:0002843 name: regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002413 ! tolerance induction to tumor cell relationship: regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002844 name: negative regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of tolerance induction to tumor cell" EXACT [] synonym: "downregulation of tolerance induction to tumor cell" EXACT [] synonym: "inhibition of tolerance induction to tumor cell" NARROW [] synonym: "negative regulation of tolerance induction to tumour cell" EXACT [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002413 ! tolerance induction to tumor cell relationship: negatively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002845 name: positive regulation of tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of tolerance induction to tumor cell." [GOC:add] synonym: "activation of tolerance induction to tumor cell" NARROW [] synonym: "positive regulation of tolerance induction to tumour cell" EXACT [] synonym: "stimulation of tolerance induction to tumor cell" NARROW [] synonym: "up regulation of tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of tolerance induction to tumor cell" EXACT [] synonym: "upregulation of tolerance induction to tumor cell" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002413 ! tolerance induction to tumor cell relationship: positively_regulates GO:0002413 ! tolerance induction to tumor cell [Term] id: GO:0002846 name: regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell is_a: GO:0002843 ! regulation of tolerance induction to tumor cell is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002847 name: negative regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "down regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "down-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "downregulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "inhibition of T cell tolerance induction to tumor cell" NARROW [] is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002844 ! negative regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002850 ! negative regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: negatively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002848 name: positive regulation of T cell tolerance induction to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell tolerance induction to tumor cell." [GOC:add] synonym: "activation of T cell tolerance induction to tumor cell" NARROW [] synonym: "stimulation of T cell tolerance induction to tumor cell" NARROW [] synonym: "up regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "up-regulation of T cell tolerance induction to tumor cell" EXACT [] synonym: "upregulation of T cell tolerance induction to tumor cell" EXACT [] is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002845 ! positive regulation of tolerance induction to tumor cell is_a: GO:0002846 ! regulation of T cell tolerance induction to tumor cell is_a: GO:0002851 ! positive regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell relationship: positively_regulates GO:0002411 ! T cell tolerance induction to tumor cell [Term] id: GO:0002849 name: regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002664 ! regulation of T cell tolerance induction is_a: GO:0002709 ! regulation of T cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002458 ! peripheral T cell tolerance induction relationship: regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002850 name: negative regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "down regulation of peripheral T cell tolerance induction" EXACT [] synonym: "down-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "downregulation of peripheral T cell tolerance induction" EXACT [] synonym: "inhibition of peripheral T cell tolerance induction" NARROW [] is_a: GO:0002659 ! negative regulation of peripheral tolerance induction is_a: GO:0002665 ! negative regulation of T cell tolerance induction is_a: GO:0002710 ! negative regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction relationship: negatively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002851 name: positive regulation of peripheral T cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral T cell tolerance induction." [GOC:add] synonym: "activation of peripheral T cell tolerance induction" NARROW [] synonym: "stimulation of peripheral T cell tolerance induction" NARROW [] synonym: "up regulation of peripheral T cell tolerance induction" EXACT [] synonym: "up-regulation of peripheral T cell tolerance induction" EXACT [] synonym: "upregulation of peripheral T cell tolerance induction" EXACT [] is_a: GO:0002660 ! positive regulation of peripheral tolerance induction is_a: GO:0002666 ! positive regulation of T cell tolerance induction is_a: GO:0002711 ! positive regulation of T cell mediated immunity is_a: GO:0002849 ! regulation of peripheral T cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002458 ! peripheral T cell tolerance induction relationship: positively_regulates GO:0002458 ! peripheral T cell tolerance induction [Term] id: GO:0002852 name: regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] is_a: GO:0001914 ! regulation of T cell mediated cytotoxicity is_a: GO:0002840 ! regulation of T cell mediated immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002853 name: negative regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "down regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0001915 ! negative regulation of T cell mediated cytotoxicity is_a: GO:0002841 ! negative regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002854 name: positive regulation of T cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of T cell mediated cytotoxicity directed against a tumor cell target." [GOC:add] synonym: "activation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of T cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of T cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0001916 ! positive regulation of T cell mediated cytotoxicity is_a: GO:0002842 ! positive regulation of T cell mediated immune response to tumor cell is_a: GO:0002852 ! regulation of T cell mediated cytotoxicity directed against tumor cell target intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002419 ! T cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002855 name: regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] is_a: GO:0002715 ! regulation of natural killer cell mediated immunity is_a: GO:0002837 ! regulation of immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002856 name: negative regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "down regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "down-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "downregulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "inhibition of natural killer cell mediated immune response to tumor cell" NARROW [] is_a: GO:0002716 ! negative regulation of natural killer cell mediated immunity is_a: GO:0002838 ! negative regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: negatively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002857 name: positive regulation of natural killer cell mediated immune response to tumor cell namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated immune response to a tumor cell." [GOC:add] synonym: "activation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "stimulation of natural killer cell mediated immune response to tumor cell" NARROW [] synonym: "up regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "up-regulation of natural killer cell mediated immune response to tumor cell" EXACT [] synonym: "upregulation of natural killer cell mediated immune response to tumor cell" EXACT [] is_a: GO:0002717 ! positive regulation of natural killer cell mediated immunity is_a: GO:0002839 ! positive regulation of immune response to tumor cell is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell relationship: positively_regulates GO:0002423 ! natural killer cell mediated immune response to tumor cell [Term] id: GO:0002858 name: regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] is_a: GO:0002855 ! regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0042269 ! regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002859 name: negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "down regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "down-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "downregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "inhibition of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] is_a: GO:0002856 ! negative regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045953 ! negative regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: negatively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002860 name: positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell mediated cytotoxicity directed against tumor cell target." [GOC:add] synonym: "activation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "stimulation of natural killer cell mediated cytotoxicity directed against tumor cell target" NARROW [] synonym: "up regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "up-regulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] synonym: "upregulation of natural killer cell mediated cytotoxicity directed against tumor cell target" EXACT [] is_a: GO:0002857 ! positive regulation of natural killer cell mediated immune response to tumor cell is_a: GO:0002858 ! regulation of natural killer cell mediated cytotoxicity directed against tumor cell target is_a: GO:0045954 ! positive regulation of natural killer cell mediated cytotoxicity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target relationship: positively_regulates GO:0002420 ! natural killer cell mediated cytotoxicity directed against tumor cell target [Term] id: GO:0002861 name: regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0050727 ! regulation of inflammatory response is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002862 name: negative regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050728 ! negative regulation of inflammatory response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002863 name: positive regulation of inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus is_a: GO:0050729 ! positive regulation of inflammatory response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002437 ! inflammatory response to antigenic stimulus [Term] id: GO:0002864 name: regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002865 name: negative regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002866 name: positive regulation of acute inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002438 ! acute inflammatory response to antigenic stimulus [Term] id: GO:0002867 name: regulation of B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "regulation of B lymphocyte deletion" EXACT [] synonym: "regulation of B-cell deletion" EXACT [] synonym: "regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002661 ! regulation of B cell tolerance induction is_a: GO:0002902 ! regulation of B cell apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002516 ! B cell deletion relationship: regulates GO:0002516 ! B cell deletion [Term] id: GO:0002868 name: negative regulation of B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "down regulation of B cell deletion" EXACT [] synonym: "down-regulation of B cell deletion" EXACT [] synonym: "downregulation of B cell deletion" EXACT [] synonym: "inhibition of B cell deletion" NARROW [] synonym: "negative regulation of B lymphocyte deletion" EXACT [] synonym: "negative regulation of B-cell deletion" EXACT [] synonym: "negative regulation of B-lymphocyte deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002903 ! negative regulation of B cell apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002516 ! B cell deletion relationship: negatively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002869 name: positive regulation of B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell deletion." [GOC:add] synonym: "activation of B cell deletion" NARROW [] synonym: "positive regulation of B lymphocyte deletion" EXACT [] synonym: "positive regulation of B-cell deletion" EXACT [] synonym: "positive regulation of B-lymphocyte deletion" EXACT [] synonym: "stimulation of B cell deletion" NARROW [] synonym: "up regulation of B cell deletion" EXACT [] synonym: "up-regulation of B cell deletion" EXACT [] synonym: "upregulation of B cell deletion" EXACT [] is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002904 ! positive regulation of B cell apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002516 ! B cell deletion relationship: positively_regulates GO:0002516 ! B cell deletion [Term] id: GO:0002870 name: T cell anergy namespace: biological_process def: "Any process contributing to anergy in T cells, a state of functional inactivation which is part of T cell tolerance induction." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "T lymphocyte anergy" EXACT [] synonym: "T-cell anergy" EXACT [] synonym: "T-lymphocyte anergy" EXACT [] is_a: GO:0002249 ! lymphocyte anergy is_a: GO:0002517 ! T cell tolerance induction [Term] id: GO:0002871 name: regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002519 ! natural killer cell tolerance induction relationship: regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002872 name: negative regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "down regulation of natural killer cell tolerance induction" EXACT [] synonym: "down-regulation of natural killer cell tolerance induction" EXACT [] synonym: "downregulation of natural killer cell tolerance induction" EXACT [] synonym: "inhibition of natural killer cell tolerance induction" NARROW [] synonym: "negative regulation of NK cell tolerance induction" EXACT [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002519 ! natural killer cell tolerance induction relationship: negatively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002873 name: positive regulation of natural killer cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of natural killer cell tolerance induction." [GOC:add] synonym: "activation of natural killer cell tolerance induction" NARROW [] synonym: "positive regulation of NK cell tolerance induction" EXACT [] synonym: "stimulation of natural killer cell tolerance induction" NARROW [] synonym: "up regulation of natural killer cell tolerance induction" EXACT [] synonym: "up-regulation of natural killer cell tolerance induction" EXACT [] synonym: "upregulation of natural killer cell tolerance induction" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002673 ! regulation of acute inflammatory response is_a: GO:0002871 ! regulation of natural killer cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002519 ! natural killer cell tolerance induction relationship: positively_regulates GO:0002519 ! natural killer cell tolerance induction [Term] id: GO:0002874 name: regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response is_a: GO:0002861 ! regulation of inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002875 name: negative regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002862 ! negative regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: negatively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002876 name: positive regulation of chronic inflammatory response to antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to an antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002863 ! positive regulation of inflammatory response to antigenic stimulus is_a: GO:0002874 ! regulation of chronic inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus relationship: positively_regulates GO:0002439 ! chronic inflammatory response to antigenic stimulus [Term] id: GO:0002877 name: regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002673 ! regulation of acute inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002878 name: negative regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of acute inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002674 ! negative regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002879 name: positive regulation of acute inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an acute inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of acute inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of acute inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of acute inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002675 ! positive regulation of acute inflammatory response is_a: GO:0002877 ! regulation of acute inflammatory response to non-antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002525 ! acute inflammatory response to non-antigenic stimulus [Term] id: GO:0002880 name: regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] is_a: GO:0002676 ! regulation of chronic inflammatory response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002881 name: negative regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "down regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "down-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "downregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "inhibition of chronic inflammatory response to non-antigenic stimulus" NARROW [] is_a: GO:0002677 ! negative regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: negatively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002882 name: positive regulation of chronic inflammatory response to non-antigenic stimulus namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a chronic inflammatory response to a non-antigenic stimulus." [GOC:add] synonym: "activation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "stimulation of chronic inflammatory response to non-antigenic stimulus" NARROW [] synonym: "up regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "up-regulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] synonym: "upregulation of chronic inflammatory response to non-antigenic stimulus" EXACT [] is_a: GO:0002678 ! positive regulation of chronic inflammatory response is_a: GO:0002880 ! regulation of chronic inflammatory response to non-antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus relationship: positively_regulates GO:0002545 ! chronic inflammatory response to non-antigenic stimulus [Term] id: GO:0002883 name: regulation of hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of hypersensitivity." [GOC:add] is_a: GO:0002864 ! regulation of acute inflammatory response to antigenic stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002524 ! hypersensitivity relationship: regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002884 name: negative regulation of hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "down regulation of hypersensitivity" EXACT [] synonym: "down-regulation of hypersensitivity" EXACT [] synonym: "downregulation of hypersensitivity" EXACT [] synonym: "inhibition of hypersensitivity" NARROW [] is_a: GO:0002865 ! negative regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002524 ! hypersensitivity relationship: negatively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002885 name: positive regulation of hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of hypersensitivity." [GOC:add] synonym: "activation of hypersensitivity" NARROW [] synonym: "stimulation of hypersensitivity" NARROW [] synonym: "up regulation of hypersensitivity" EXACT [] synonym: "up-regulation of hypersensitivity" EXACT [] synonym: "upregulation of hypersensitivity" EXACT [] is_a: GO:0002866 ! positive regulation of acute inflammatory response to antigenic stimulus is_a: GO:0002883 ! regulation of hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002524 ! hypersensitivity relationship: positively_regulates GO:0002524 ! hypersensitivity [Term] id: GO:0002886 name: regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] is_a: GO:0002703 ! regulation of leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002887 name: negative regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "down regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "down-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "downregulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "inhibition of myeloid leukocyte mediated immunity" NARROW [] is_a: GO:0002704 ! negative regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: negatively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002888 name: positive regulation of myeloid leukocyte mediated immunity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of myeloid leukocyte mediated immunity." [GOC:add] synonym: "activation of myeloid leukocyte mediated immunity" NARROW [] synonym: "stimulation of myeloid leukocyte mediated immunity" NARROW [] synonym: "up regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "up-regulation of myeloid leukocyte mediated immunity" EXACT [] synonym: "upregulation of myeloid leukocyte mediated immunity" EXACT [] is_a: GO:0002705 ! positive regulation of leukocyte mediated immunity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity relationship: positively_regulates GO:0002444 ! myeloid leukocyte mediated immunity [Term] id: GO:0002889 name: regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016064 ! immunoglobulin mediated immune response relationship: regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002890 name: negative regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "down regulation of immunoglobulin mediated immune response" EXACT [] synonym: "down-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "downregulation of immunoglobulin mediated immune response" EXACT [] synonym: "inhibition of immunoglobulin mediated immune response" NARROW [] is_a: GO:0002713 ! negative regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: negatively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002891 name: positive regulation of immunoglobulin mediated immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of an immunoglobulin mediated immune response." [GOC:add] synonym: "activation of immunoglobulin mediated immune response" NARROW [] synonym: "stimulation of immunoglobulin mediated immune response" NARROW [] synonym: "up regulation of immunoglobulin mediated immune response" EXACT [] synonym: "up-regulation of immunoglobulin mediated immune response" EXACT [] synonym: "upregulation of immunoglobulin mediated immune response" EXACT [] is_a: GO:0002714 ! positive regulation of B cell mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0016064 ! immunoglobulin mediated immune response relationship: positively_regulates GO:0016064 ! immunoglobulin mediated immune response [Term] id: GO:0002892 name: regulation of type II hypersensitivity namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of type II hypersensitivity." [GOC:add] is_a: GO:0002883 ! regulation of hypersensitivity is_a: GO:0002886 ! regulation of myeloid leukocyte mediated immunity is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002445 ! type II hypersensitivity relationship: regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002893 name: negative regulation of type II hypersensitivity namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "down regulation of type II hypersensitivity" EXACT [] synonym: "down-regulation of type II hypersensitivity" EXACT [] synonym: "downregulation of type II hypersensitivity" EXACT [] synonym: "inhibition of type II hypersensitivity" NARROW [] is_a: GO:0002884 ! negative regulation of hypersensitivity is_a: GO:0002887 ! negative regulation of myeloid leukocyte mediated immunity is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002445 ! type II hypersensitivity relationship: negatively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002894 name: positive regulation of type II hypersensitivity namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of type II hypersensitivity." [GOC:add] synonym: "activation of type II hypersensitivity" NARROW [] synonym: "stimulation of type II hypersensitivity" NARROW [] synonym: "up regulation of type II hypersensitivity" EXACT [] synonym: "up-regulation of type II hypersensitivity" EXACT [] synonym: "upregulation of type II hypersensitivity" EXACT [] is_a: GO:0002885 ! positive regulation of hypersensitivity is_a: GO:0002888 ! positive regulation of myeloid leukocyte mediated immunity is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002892 ! regulation of type II hypersensitivity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002445 ! type II hypersensitivity relationship: positively_regulates GO:0002445 ! type II hypersensitivity [Term] id: GO:0002895 name: regulation of central B cell tolerance induction namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] is_a: GO:0002646 ! regulation of central tolerance induction is_a: GO:0002661 ! regulation of B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002510 ! central B cell tolerance induction relationship: regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002896 name: negative regulation of central B cell tolerance induction namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "down regulation of central B cell tolerance induction" EXACT [] synonym: "down-regulation of central B cell tolerance induction" EXACT [] synonym: "downregulation of central B cell tolerance induction" EXACT [] synonym: "inhibition of central B cell tolerance induction" NARROW [] is_a: GO:0002647 ! negative regulation of central tolerance induction is_a: GO:0002662 ! negative regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002510 ! central B cell tolerance induction relationship: negatively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002897 name: positive regulation of central B cell tolerance induction namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell tolerance induction." [GOC:add] synonym: "activation of central B cell tolerance induction" NARROW [] synonym: "stimulation of central B cell tolerance induction" NARROW [] synonym: "up regulation of central B cell tolerance induction" EXACT [] synonym: "up-regulation of central B cell tolerance induction" EXACT [] synonym: "upregulation of central B cell tolerance induction" EXACT [] is_a: GO:0002648 ! positive regulation of central tolerance induction is_a: GO:0002663 ! positive regulation of B cell tolerance induction is_a: GO:0002895 ! regulation of central B cell tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002510 ! central B cell tolerance induction relationship: positively_regulates GO:0002510 ! central B cell tolerance induction [Term] id: GO:0002898 name: regulation of central B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell deletion." [GOC:add] is_a: GO:0002867 ! regulation of B cell deletion is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002342 ! central B cell deletion relationship: regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002899 name: negative regulation of central B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "down regulation of central B cell deletion" EXACT [] synonym: "down-regulation of central B cell deletion" EXACT [] synonym: "downregulation of central B cell deletion" EXACT [] synonym: "inhibition of central B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002342 ! central B cell deletion relationship: negatively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002900 name: positive regulation of central B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell deletion." [GOC:add] synonym: "activation of central B cell deletion" NARROW [] synonym: "stimulation of central B cell deletion" NARROW [] synonym: "up regulation of central B cell deletion" EXACT [] synonym: "up-regulation of central B cell deletion" EXACT [] synonym: "upregulation of central B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002898 ! regulation of central B cell deletion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002342 ! central B cell deletion relationship: positively_regulates GO:0002342 ! central B cell deletion [Term] id: GO:0002901 name: mature B cell apoptosis namespace: biological_process def: "The process of apoptosis in mature B cells." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "apoptosis of mature B cells" EXACT [] synonym: "apoptosis of mature B lymphocytes" EXACT [] synonym: "apoptosis of mature B-cells" EXACT [] synonym: "apoptosis of mature B-lymphocytes" EXACT [] synonym: "mature B cell programmed cell death by apoptosis" EXACT [] synonym: "mature B lymphocyte apoptosis" EXACT [] synonym: "mature B lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "mature B-cell apoptosis" EXACT [] synonym: "mature B-cell programmed cell death by apoptosis" EXACT [] synonym: "mature B-lymphocyte apoptosis" EXACT [] synonym: "mature B-lymphocyte programmed cell death by apoptosis" EXACT [] synonym: "programmed cell death of mature B cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death of mature B-cells by apoptosis" EXACT [] synonym: "programmed cell death of mature B-lymphocytes by apoptosis" EXACT [] synonym: "programmed cell death, mature B cells" EXACT [] synonym: "programmed cell death, mature B lymphocytes" EXACT [] synonym: "programmed cell death, mature B-cells" EXACT [] synonym: "programmed cell death, mature B-lymphocytes" EXACT [] is_a: GO:0001783 ! B cell apoptosis relationship: part_of GO:0001782 ! B cell homeostasis [Term] id: GO:0002902 name: regulation of B cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of B cell apoptosis." [GOC:add] is_a: GO:0070228 ! regulation of lymphocyte apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0001783 ! B cell apoptosis relationship: regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002903 name: negative regulation of B cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of B cell apoptosis." [GOC:add] synonym: "down regulation of B cell apoptosis" EXACT [] synonym: "down-regulation of B cell apoptosis" EXACT [] synonym: "downregulation of B cell apoptosis" EXACT [] synonym: "inhibition of B cell apoptosis" NARROW [] is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0070229 ! negative regulation of lymphocyte apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001783 ! B cell apoptosis relationship: negatively_regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002904 name: positive regulation of B cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of B cell apoptosis." [GOC:add] synonym: "activation of B cell apoptosis" NARROW [] synonym: "stimulation of B cell apoptosis" NARROW [] synonym: "up regulation of B cell apoptosis" EXACT [] synonym: "up-regulation of B cell apoptosis" EXACT [] synonym: "upregulation of B cell apoptosis" EXACT [] is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0070230 ! positive regulation of lymphocyte apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0001783 ! B cell apoptosis relationship: positively_regulates GO:0001783 ! B cell apoptosis [Term] id: GO:0002905 name: regulation of mature B cell apoptosis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] is_a: GO:0002682 ! regulation of immune system process is_a: GO:0002902 ! regulation of B cell apoptosis is_a: GO:0032844 ! regulation of homeostatic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002901 ! mature B cell apoptosis relationship: regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002906 name: negative regulation of mature B cell apoptosis namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] synonym: "down regulation of mature B cell apoptosis" EXACT [] synonym: "down-regulation of mature B cell apoptosis" EXACT [] synonym: "downregulation of mature B cell apoptosis" EXACT [] synonym: "inhibition of mature B cell apoptosis" NARROW [] is_a: GO:0002903 ! negative regulation of B cell apoptosis is_a: GO:0002905 ! regulation of mature B cell apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002901 ! mature B cell apoptosis relationship: negatively_regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002907 name: positive regulation of mature B cell apoptosis namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of mature B cell apoptosis." [GOC:add] synonym: "activation of mature B cell apoptosis" NARROW [] synonym: "stimulation of mature B cell apoptosis" NARROW [] synonym: "up regulation of mature B cell apoptosis" EXACT [] synonym: "up-regulation of mature B cell apoptosis" EXACT [] synonym: "upregulation of mature B cell apoptosis" EXACT [] is_a: GO:0002904 ! positive regulation of B cell apoptosis is_a: GO:0002905 ! regulation of mature B cell apoptosis intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002901 ! mature B cell apoptosis relationship: positively_regulates GO:0002901 ! mature B cell apoptosis [Term] id: GO:0002908 name: regulation of peripheral B cell deletion namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002712 ! regulation of B cell mediated immunity is_a: GO:0002867 ! regulation of B cell deletion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002454 ! peripheral B cell deletion relationship: regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002909 name: negative regulation of peripheral B cell deletion namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "down regulation of peripheral B cell deletion" EXACT [] synonym: "down-regulation of peripheral B cell deletion" EXACT [] synonym: "downregulation of peripheral B cell deletion" EXACT [] synonym: "inhibition of peripheral B cell deletion" NARROW [] is_a: GO:0002868 ! negative regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002454 ! peripheral B cell deletion relationship: negatively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002910 name: positive regulation of peripheral B cell deletion namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell deletion." [GOC:add] synonym: "activation of peripheral B cell deletion" NARROW [] synonym: "stimulation of peripheral B cell deletion" NARROW [] synonym: "up regulation of peripheral B cell deletion" EXACT [] synonym: "up-regulation of peripheral B cell deletion" EXACT [] synonym: "upregulation of peripheral B cell deletion" EXACT [] is_a: GO:0002869 ! positive regulation of B cell deletion is_a: GO:0002908 ! regulation of peripheral B cell deletion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002454 ! peripheral B cell deletion relationship: positively_regulates GO:0002454 ! peripheral B cell deletion [Term] id: GO:0002911 name: regulation of lymphocyte anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of lymphocyte anergy." [GOC:add] is_a: GO:0002643 ! regulation of tolerance induction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002249 ! lymphocyte anergy relationship: regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002912 name: negative regulation of lymphocyte anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "down regulation of lymphocyte anergy" EXACT [] synonym: "down-regulation of lymphocyte anergy" EXACT [] synonym: "downregulation of lymphocyte anergy" EXACT [] synonym: "inhibition of lymphocyte anergy" NARROW [] is_a: GO:0002644 ! negative regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002249 ! lymphocyte anergy relationship: negatively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002913 name: positive regulation of lymphocyte anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of lymphocyte anergy." [GOC:add] synonym: "activation of lymphocyte anergy" NARROW [] synonym: "stimulation of lymphocyte anergy" NARROW [] synonym: "up regulation of lymphocyte anergy" EXACT [] synonym: "up-regulation of lymphocyte anergy" EXACT [] synonym: "upregulation of lymphocyte anergy" EXACT [] is_a: GO:0002645 ! positive regulation of tolerance induction is_a: GO:0002911 ! regulation of lymphocyte anergy intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002249 ! lymphocyte anergy relationship: positively_regulates GO:0002249 ! lymphocyte anergy [Term] id: GO:0002914 name: regulation of central B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of central B cell anergy." [GOC:add] is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002895 ! regulation of central B cell tolerance induction is_a: GO:0045577 ! regulation of B cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002341 ! central B cell anergy relationship: regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002915 name: negative regulation of central B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "down regulation of central B cell anergy" EXACT [] synonym: "down-regulation of central B cell anergy" EXACT [] synonym: "downregulation of central B cell anergy" EXACT [] synonym: "inhibition of central B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002341 ! central B cell anergy relationship: negatively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002916 name: positive regulation of central B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of central B cell anergy." [GOC:add] synonym: "activation of central B cell anergy" NARROW [] synonym: "stimulation of central B cell anergy" NARROW [] synonym: "up regulation of central B cell anergy" EXACT [] synonym: "up-regulation of central B cell anergy" EXACT [] synonym: "upregulation of central B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002914 ! regulation of central B cell anergy intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002341 ! central B cell anergy relationship: positively_regulates GO:0002341 ! central B cell anergy [Term] id: GO:0002917 name: regulation of peripheral B cell anergy namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] is_a: GO:0002658 ! regulation of peripheral tolerance induction is_a: GO:0002670 ! regulation of B cell anergy is_a: GO:0002712 ! regulation of B cell mediated immunity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002453 ! peripheral B cell anergy relationship: regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002918 name: negative regulation of peripheral B cell anergy namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "down regulation of peripheral B cell anergy" EXACT [] synonym: "down-regulation of peripheral B cell anergy" EXACT [] synonym: "downregulation of peripheral B cell anergy" EXACT [] synonym: "inhibition of peripheral B cell anergy" NARROW [] is_a: GO:0002671 ! negative regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002453 ! peripheral B cell anergy relationship: negatively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002919 name: positive regulation of peripheral B cell anergy namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of peripheral B cell anergy." [GOC:add] synonym: "activation of peripheral B cell anergy" NARROW [] synonym: "stimulation of peripheral B cell anergy" NARROW [] synonym: "up regulation of peripheral B cell anergy" EXACT [] synonym: "up-regulation of peripheral B cell anergy" EXACT [] synonym: "upregulation of peripheral B cell anergy" EXACT [] is_a: GO:0002672 ! positive regulation of B cell anergy is_a: GO:0002917 ! regulation of peripheral B cell anergy intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002453 ! peripheral B cell anergy relationship: positively_regulates GO:0002453 ! peripheral B cell anergy [Term] id: GO:0002920 name: regulation of humoral immune response namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response." [GOC:add] is_a: GO:0050776 ! regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006959 ! humoral immune response relationship: regulates GO:0006959 ! humoral immune response [Term] id: GO:0002921 name: negative regulation of humoral immune response namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "down regulation of humoral immune response" EXACT [] synonym: "down-regulation of humoral immune response" EXACT [] synonym: "downregulation of humoral immune response" EXACT [] synonym: "inhibition of humoral immune response" NARROW [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050777 ! negative regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006959 ! humoral immune response relationship: negatively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002922 name: positive regulation of humoral immune response namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response." [GOC:add] synonym: "activation of humoral immune response" NARROW [] synonym: "stimulation of humoral immune response" NARROW [] synonym: "up regulation of humoral immune response" EXACT [] synonym: "up-regulation of humoral immune response" EXACT [] synonym: "upregulation of humoral immune response" EXACT [] is_a: GO:0002920 ! regulation of humoral immune response is_a: GO:0050778 ! positive regulation of immune response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006959 ! humoral immune response relationship: positively_regulates GO:0006959 ! humoral immune response [Term] id: GO:0002923 name: regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] is_a: GO:0002889 ! regulation of immunoglobulin mediated immune response is_a: GO:0002920 ! regulation of humoral immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002924 name: negative regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "down regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "down-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "downregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "inhibition of humoral immune response mediated by circulating immunoglobulin" NARROW [] is_a: GO:0002890 ! negative regulation of immunoglobulin mediated immune response is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: negatively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0002925 name: positive regulation of humoral immune response mediated by circulating immunoglobulin namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of a humoral immune response mediated by circulating immunoglobulin." [GOC:add] synonym: "activation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "stimulation of humoral immune response mediated by circulating immunoglobulin" NARROW [] synonym: "up regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "up-regulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] synonym: "upregulation of humoral immune response mediated by circulating immunoglobulin" EXACT [] is_a: GO:0002891 ! positive regulation of immunoglobulin mediated immune response is_a: GO:0002922 ! positive regulation of humoral immune response is_a: GO:0002923 ! regulation of humoral immune response mediated by circulating immunoglobulin intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin relationship: positively_regulates GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0003001 name: generation of a signal involved in cell-cell signaling namespace: biological_process def: "The cellular process by which a physical entity or change in state, a signal, is created that originates in one cell and is used to transfer information to another cell. This process begins with the initial formation of the signal and ends with the mature form and placement of the signal." [GOC:dph] synonym: "formation of a signal" BROAD [] synonym: "generation of a signal involved in cell-cell signalling" EXACT [] synonym: "signal generation" BROAD [] is_a: GO:0009987 ! cellular process is_a: GO:0023046 ! signaling process relationship: part_of GO:0007267 ! cell-cell signaling [Term] id: GO:0003002 name: regionalization namespace: biological_process def: "The pattern specification process by which an axis or axes is subdivided in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment." [GOC:dph, GOC:isa_complete] synonym: "pattern formation" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0003003 name: follicular fluid formation in ovarian follicle antrum involved in fused antrum stage namespace: biological_process def: "The ovulation cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the fused antrum stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during fused antrum stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048165 ! fused antrum stage [Term] id: GO:0003004 name: follicular fluid formation in ovarian follicle antrum involved in distinct antral spaces stage namespace: biological_process def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during distinct antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048164 ! distinct antral spaces stage [Term] id: GO:0003005 name: follicular fluid formation in ovarian follicle antrum involved in scattered antral spaces stage namespace: biological_process def: "The menstrual cycle process by which one central cavity separating the oocyte/cumulus complex from mural granulosa and theca cells is formed as part of the scattered antral spaces stage of oogenesis." [GOC:dph, GOC:isa_complete] synonym: "follicular fluid formation in ovarian follicle antrum during scattered antral spaces stage" RELATED [GOC:dph, GOC:tb] is_a: GO:0001548 ! follicular fluid formation in ovarian follicle antrum relationship: part_of GO:0048163 ! scattered antral spaces stage [Term] id: GO:0003006 name: reproductive developmental process namespace: biological_process def: "A developmental process by which a progressive change in the state of some part of an organism specifically contributes to its ability to form offspring." [GOC:dph, GOC:isa_complete] is_a: GO:0022414 ! reproductive process is_a: GO:0032502 ! developmental process [Term] id: GO:0003007 name: heart morphogenesis namespace: biological_process def: "The developmental process by which the heart is generated and organized. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:dph, GOC:isa_complete] synonym: "cardiac morphogenesis" RELATED [] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0007507 ! heart development [Term] id: GO:0003008 name: system process namespace: biological_process def: "A multicellular organismal process carried out by any of the organs or tissues in an organ system. An organ system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a biological objective." [GOC:mtg_cardio] synonym: "organ system process" EXACT [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0003009 name: skeletal muscle contraction namespace: biological_process def: "A process whereby force is generated within skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and in most cases it is under voluntary control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0006941 ! striated muscle contraction relationship: part_of GO:0050881 ! musculoskeletal movement [Term] id: GO:0003010 name: voluntary skeletal muscle contraction namespace: biological_process def: "A process whereby force is generated within voluntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. In the voluntary skeletal muscle, the muscle contraction takes advantage of an ordered sarcomeric structure and it is under voluntary control. Voluntary skeletal muscle is skeletal muscle that is under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003011 name: involuntary skeletal muscle contraction namespace: biological_process def: "A process whereby force is generated within involuntary skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Involuntary skeletal muscle is skeletal muscle that is not under conscious control." [GOC:mtg_cardio, GOC:mtg_muscle] is_a: GO:0003009 ! skeletal muscle contraction [Term] id: GO:0003012 name: muscle system process namespace: biological_process def: "A organ system process carried out at the level of a muscle. Muscle tissue is composed of contractile cells or fibers." [GOC:mtg_cardio] synonym: "muscle physiological process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003013 name: circulatory system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the circulatory system. The circulatory system is an organ system that moves extracellular fluids to and from tissue within a multicellular organism." [GOC:mtg_cardio] xref: Wikipedia:Circulatory_system is_a: GO:0003008 ! system process [Term] id: GO:0003014 name: renal system process namespace: biological_process def: "A organ system process carried out by any of the organs or tissues of the renal system. The renal system is responsible for fluid volume regulation and detoxification in an organism." [GOC:mtg_cardio] synonym: "kidney system process" RELATED [] is_a: GO:0003008 ! system process [Term] id: GO:0003015 name: heart process namespace: biological_process def: "A circulatory system process carried out by the heart. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:mtg_cardio] synonym: "cardiac process" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003016 name: respiratory system process namespace: biological_process alt_id: GO:0010802 def: "A system process carried out by the organs and tissues of the respiratory system. The respiratory system is an organ system responsible for respiratory gaseous exchange." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "respiratory gaseous exchange by respiratory system" EXACT [] is_a: GO:0003008 ! system process is_a: GO:0007585 ! respiratory gaseous exchange [Term] id: GO:0003017 name: lymph circulation namespace: biological_process def: "The flow of lymph through the body of an animal." [GOC:mtg_cardio] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003018 name: vascular process in circulatory system namespace: biological_process def: "A circulatory process that occurs at the level of the vasculature." [GOC:mtg_cardio] synonym: "vasculature process" EXACT [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0003019 name: central nervous system control of baroreceptor feedback namespace: biological_process def: "The neurological process by which nerve impulses arising in the aorta or the carotid sinuses travel to the medulla and reach the nucleus of tractus solaris." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] is_a: GO:0050877 ! neurological system process relationship: part_of GO:0001978 ! regulation of systemic arterial blood pressure by carotid sinus baroreceptor feedback [Term] id: GO:0003020 name: detection of reduced oxygen by chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of reduced oxygen by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0070483 ! detection of hypoxia relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003021 name: detection of increased carbon dioxide by chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of increased carbon dioxide by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003031 ! detection of carbon dioxide relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003022 name: detection of pH by chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in the carotid bodies and the aortic bodies." [GOC:mtg_cardio, ISBN:0323031951 "Principles of Physiology"] synonym: "detection of pH by chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003030 ! detection of hydrogen ion relationship: part_of GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling [Term] id: GO:0003023 name: baroreceptor detection of increased arterial stretch namespace: biological_process def: "The series of events by which an increase in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001983 ! baroreceptor response to increased systemic arterial blood pressure [Term] id: GO:0003024 name: baroreceptor detection of decreased arterial stretch namespace: biological_process def: "The series of events by which a decrease in diameter of an artery is detected and converted to a molecular signal." [GOC:mtg_cardio] is_a: GO:0001981 ! baroreceptor detection of arterial stretch relationship: part_of GO:0001982 ! baroreceptor response to decreased systemic arterial blood pressure [Term] id: GO:0003025 name: regulation of systemic arterial blood pressure by baroreceptor feedback namespace: biological_process def: "The neural regulation of blood pressure in which baroreceptors sense the amount of stretch occurring in vessels and respond to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "baroreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003026 name: regulation of systemic arterial blood pressure by aortic arch baroreceptor feedback namespace: biological_process def: "The process that modulates blood pressure by sensing the amount of stretch occurring in the aorta and responding to the input via central nervous system control." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic arch baroreceptor control of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure relationship: part_of GO:0003025 ! regulation of systemic arterial blood pressure by baroreceptor feedback [Term] id: GO:0003027 name: regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the carotid bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "carotid body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "carotid body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by carotid body chemoreceptor signalling" EXACT [GOC:mah] synonym: "vagal reflex" BROAD [] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003028 name: regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling namespace: biological_process def: "The process that modulates blood pressure by the action of chemoreceptors found in the aortic bodies and their resultant modulation of the vasomotor center. Chemoreceptors respond to oxygen, carbon dioxide and hydrogen ions." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "aortic body chemoreceptor regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] synonym: "aortic body chemoreceptor response to lowering of systemic arterial blood pressure" EXACT [GOC:dph] synonym: "regulation of systemic arterial blood pressure by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0001979 ! regulation of systemic arterial blood pressure by chemoreceptor signaling [Term] id: GO:0003029 name: detection of hypoxic conditions in blood by carotid body chemoreceptor signaling namespace: biological_process def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the carotid bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003030 name: detection of hydrogen ion namespace: biological_process def: "The series of events in which a hydrogen ion stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003031 name: detection of carbon dioxide namespace: biological_process def: "The series of events in which a carbon dioxide stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0003032 name: detection of oxygen namespace: biological_process def: "The series of events in which an oxygen stimulus is received by a cell and converted into a molecular signal." [GOC:mtg_cardio] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0070482 ! response to oxygen levels [Term] id: GO:0003033 name: detection of hypoxic conditions in blood by aortic body chemoreceptor signaling namespace: biological_process def: "The process by which information about a lack of oxygen are received and are converted to a molecular signal by chemoreceptors in the aortic bodies." [GOC:mtg_cardio] synonym: "detection of hypoxic conditions in blood by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002007 ! detection of hypoxic conditions in blood by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003034 name: detection of increased carbon dioxide by aortic body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003035 name: detection of increased carbon dioxide by carotid body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of carbon dioxideare received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of increased carbon dioxide by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003021 ! detection of increased carbon dioxide by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003036 name: detection of pH by aortic body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of pH by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003037 name: detection of pH by carotid body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of hydrogen ions are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of pH by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003022 ! detection of pH by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003038 name: detection of reduced oxygen by aortic body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in an aortic body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003033 ! detection of hypoxic conditions in blood by aortic body chemoreceptor signaling [Term] id: GO:0003039 name: detection of reduced oxygen by carotid body chemoreceptor signaling namespace: biological_process def: "The process by which information about the levels of oxygen are received and are converted to a molecular signal by chemoreceptors in a carotid body." [GOC:mtg_cardio] synonym: "detection of reduced oxygen by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0003020 ! detection of reduced oxygen by chemoreceptor signaling relationship: part_of GO:0003029 ! detection of hypoxic conditions in blood by carotid body chemoreceptor signaling [Term] id: GO:0003040 name: excitation of vasomotor center by aortic body chemoreceptor signaling namespace: biological_process def: "The process by which the molecular signal from an aortic body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by aortic body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003041 name: excitation of vasomotor center by carotid body chemoreceptor signaling namespace: biological_process def: "The process by which the molecular signal from a carotid body is relayed to the vasomotor center, causing it to signal an increase arterial pressure." [GOC:mtg_cardio] synonym: "excitation of vasomotor center by carotid body chemoreceptor signalling" EXACT [GOC:mah] is_a: GO:0002008 ! excitation of vasomotor center by chemoreceptor signaling relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003042 name: vasoconstriction of artery involved in carotid body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by carotid body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [ISBN:0323031951 "Principles of Physiology"] synonym: "vasoconstriction of artery during carotid body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003027 ! regulation of systemic arterial blood pressure by carotid body chemoreceptor signaling [Term] id: GO:0003043 name: vasoconstriction of artery involved in aortic body chemoreceptor response to lowering of systemic arterial blood pressure namespace: biological_process def: "A process that is triggered by aortic body-vasomotor excitation and results in a decrease in the diameter of an artery during the chemoreceptor response to decreased blood pressure." [GOC:mtg_cardio] synonym: "vasoconstriction of artery during aortic body chemoreceptor response to lowering of systemic arterial blood pressure" RELATED [GOC:dph] is_a: GO:0002012 ! vasoconstriction of artery involved in chemoreceptor response to lowering of systemic arterial blood pressure relationship: part_of GO:0003028 ! regulation of systemic arterial blood pressure by aortic body chemoreceptor signaling [Term] id: GO:0003044 name: regulation of systemic arterial blood pressure mediated by a chemical signal namespace: biological_process def: "The regulation of blood pressure mediated by biochemical signaling: hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "blood pressure regulation mediated by a chemical signal" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003045 name: regulation of systemic arterial blood pressure by physical factors namespace: biological_process def: "The regulation of blood pressure mediated by detection of forces within the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by physical factors" EXACT [] is_a: GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003046 name: regulation of systemic arterial blood pressure by stress relaxation namespace: biological_process def: "The intrinsic circulatory process resulting from stress relaxation that modulates the force with which blood travels through the systemic arterial circulatory system. Stress relaxation is the adaptation of vessels to a new size as a result of changes in pressure in storage areas such as veins, the liver, the spleen, and the lungs." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by stress relaxation" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003047 name: regulation of systemic arterial blood pressure by epinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule epinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by epinephrine" RELATED [] synonym: "regulation of blood pressure by adrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003048 name: regulation of systemic arterial blood pressure by norepinephrine namespace: biological_process def: "The regulation of blood pressure mediated by the catecholamine signaling molecule norepinephrine." [GOC:mtg_cardio] synonym: "blood pressure regulation by norepinephrine" RELATED [] synonym: "regulation of blood pressure by noradrenaline" EXACT [] is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal relationship: part_of GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine [Term] id: GO:0003049 name: regulation of systemic arterial blood pressure by capillary fluid shift namespace: biological_process def: "The intrinsic circulatory process resulting from capillary fluid shift that modulates the force with which blood travels through the systemic arterial circulatory system. Capillary fluid shift is the movement of fluid across the capillary membrane between the blood and the interstitial fluid compartment." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure regulation by capillary fluid shift" EXACT [] is_a: GO:0003045 ! regulation of systemic arterial blood pressure by physical factors [Term] id: GO:0003050 name: regulation of systemic arterial blood pressure by atrial natriuretic peptide namespace: biological_process def: "The regulation of blood pressure mediated by the signaling molecule atrial natriuretic peptide." [GOC:mtg_cardio] synonym: "blood pressure regulation by ANP" RELATED [GOC:mtg_cardio] synonym: "blood pressure regulation by atrial natriuretic peptide" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003051 name: angiotensin-mediated drinking behavior namespace: biological_process def: "The drinking behavior that is mediated by the action of angiotensin in the brain. Angiotensin stimulates the brain centers that control thirst." [GOC:mtg_cardio] synonym: "angiotensin mediated drinking behavior" EXACT [GOC:dph, GOC:tb] is_a: GO:0042756 ! drinking behavior relationship: part_of GO:0002035 ! brain renin-angiotensin system [Term] id: GO:0003052 name: circadian regulation of systemic arterial blood pressure namespace: biological_process def: "Any process by which an organism modulates its blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003073 ! regulation of systemic arterial blood pressure is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003053 name: circadian regulation of heart rate namespace: biological_process def: "Any process by which an organism modulates its heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate" RELATED [] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0007623 ! circadian rhythm [Term] id: GO:0003054 name: circadian regulation of systemic arterial blood pressure by the suprachiasmatic nucleus namespace: biological_process def: "The process by which the suprachiasmatic nucleus modulates blood pressure at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "master pacemaker clock regulation of blood pressure" EXACT [] synonym: "SCN regulation of blood pressure" EXACT [] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003055 name: circadian regulation of heart rate by the suprachiasmatic nucleus namespace: biological_process def: "The process by which the suprachiasmatic nucleus modulates heart rate at different values with a regularity of approximately 24 hours." [GOC:mtg_cardio, GOC:rl] synonym: "circadian regulation of heart contraction rate by the suprachiasmatic nucleus" RELATED [] synonym: "master pacemaker clock regulation of heart rate" EXACT [] synonym: "SCN regulation of heart rate" EXACT [] is_a: GO:0003053 ! circadian regulation of heart rate [Term] id: GO:0003056 name: regulation of vascular smooth muscle contraction namespace: biological_process def: "Any process that increases the frequency, rate or extent of vascular smooth muscle contraction." [GOC:mtg_cardio, GOC:mtg_sensu, GOC:rl] is_a: GO:0006940 ! regulation of smooth muscle contraction is_a: GO:0019229 ! regulation of vasoconstriction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0014829 ! vascular smooth muscle contraction relationship: regulates GO:0014829 ! vascular smooth muscle contraction [Term] id: GO:0003057 name: regulation of the force of heart contraction by chemical signal namespace: biological_process def: "The regulation of the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio, GOC:rl] synonym: "chemical cardiac inotropy" EXACT [] synonym: "regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0002026 ! regulation of the force of heart contraction [Term] id: GO:0003058 name: hormonal regulation of the force of heart contraction namespace: biological_process def: "The process by which the hormones modulates the force of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac inotropy" EXACT [] synonym: "hormonal regulation of the force of heart muscle contraction" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal [Term] id: GO:0003059 name: positive regulation of the force of heart contraction by epinephrine namespace: biological_process def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac inotropy" EXACT [] synonym: "adrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac inotropy" EXACT [] synonym: "increased force of heart contraction by epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003060 name: negative regulation of the force of heart contraction by acetylcholine namespace: biological_process def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors and decreases the force of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "decreased force of heart contraction by acetylcholine" EXACT [] is_a: GO:0003108 ! negative regulation of the force of heart contraction by chemical signal relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003061 name: positive regulation of the force of heart contraction by norepinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings modulates the force of heart musclecontraction." [GOC:mtg_cardio, GOC:rl] synonym: "increased force of heart contraction by adrenaline" RELATED [] synonym: "increased force of heart contraction by norepinephrine" EXACT [] synonym: "noradrenaline cardiac inotropy" EXACT [] synonym: "noradrenaline regulation of the strength of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac inotropy" EXACT [] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by norepinephrine" RELATED [] is_a: GO:0003099 ! positive regulation of the force of heart contraction by chemical signal relationship: part_of GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003062 name: regulation of heart rate by chemical signal namespace: biological_process def: "The regulation of the rate of heart contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:dph, GOC:mtg_cardio, GOC:rl, GOC:tb] synonym: "chemical cardiac chronotropy" EXACT [] synonym: "chemical signal regulation of heart contraction rate" RELATED [] synonym: "chemical signal regulation of heart rate" EXACT [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate [Term] id: GO:0003063 name: negative regulation of heart rate by acetylcholine namespace: biological_process def: "The process by which acetylcholine released from vagus nerve endings binds to muscarinic receptors on the pacemaker cells and decreases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "negative regulation of heart contraction rate by acetylcholine" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010459 ! negative regulation of heart rate relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003064 name: regulation of the rate of heart contraction by hormone namespace: biological_process def: "The process by which the hormones modulates the rate of heart muscle contraction. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio, GOC:rl] synonym: "hormonal cardiac chronotropy" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal [Term] id: GO:0003065 name: positive regulation of heart rate by epinephrine namespace: biological_process def: "The process by which the secretion of epinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "adrenaline cardiac chronotropy" EXACT [] synonym: "adrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "epinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by epinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" RELATED [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003066 name: positive regulation of heart rate by norepinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine into the bloodstream or released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio, GOC:rl] synonym: "noradrenaline cardiac chronotropy" EXACT [] synonym: "noradrenaline regulation of the rate of heart muscle contraction" EXACT [] synonym: "norepinephrine cardiac chronotropy" EXACT [] synonym: "positive regulation of heart contraction rate by norepinephrine" RELATED [] synonym: "positive regulation of heart rate by adrenaline" EXACT [] is_a: GO:0003062 ! regulation of heart rate by chemical signal is_a: GO:0010460 ! positive regulation of heart rate relationship: part_of GO:0001996 ! positive regulation of heart rate by epinephrine-norepinephrine [Term] id: GO:0003067 name: circadian regulation of systemic arterial blood pressure by hormone namespace: biological_process def: "The process by which hormones modulate the force with which blood passes through the circulatory system contributing to different values of blood pressure oscillating with a regularity of approximately 24 hours. A hormone is one of a group of substances formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells, in the same organism, upon which they have a specific regulatory action." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone relationship: part_of GO:0003052 ! circadian regulation of systemic arterial blood pressure [Term] id: GO:0003068 name: regulation of systemic arterial blood pressure by acetylcholine namespace: biological_process def: "The regulation of blood pressure mediated by acetylcholine signaling. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter." [GOC:mtg_cardio, GOC:rl] synonym: "blood pressure regulation by acetylcholine" EXACT [] is_a: GO:0003070 ! regulation of systemic arterial blood pressure by neurotransmitter [Term] id: GO:0003069 name: vasodilation by acetylcholine involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The process by which acetylcholine signaling causes vasodilation, resulting in a change in blood pressure." [GOC:mtg_cardio, GOC:rl] is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure is_a: GO:0042311 ! vasodilation relationship: part_of GO:0003068 ! regulation of systemic arterial blood pressure by acetylcholine [Term] id: GO:0003070 name: regulation of systemic arterial blood pressure by neurotransmitter namespace: biological_process def: "The regulation of blood pressure mediated by a neurotransmitter. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell." [GOC:mtg_cardio, http://cancerweb.ncl.ac.uk] is_a: GO:0001976 ! neurological system process involved in regulation of systemic arterial blood pressure is_a: GO:0003044 ! regulation of systemic arterial blood pressure mediated by a chemical signal [Term] id: GO:0003071 name: renal system process involved in regulation of systemic arterial blood pressure namespace: biological_process def: "Renal process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "renal control of blood pressure" EXACT [] synonym: "renal regulation of systemic arterial blood pressure" EXACT [GOC:dph, GOC:tb] is_a: GO:0003014 ! renal system process relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003072 name: renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by impeding blood flow through the peripheral vasculature." [GOC:mtg_cardio] synonym: "regulation of systemic arterial blood pressure by renal control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] synonym: "renal regulation of systemic arterial blood pressure by control of peripheral vascular resistence" EXACT [GOC:dph, GOC:tb] is_a: GO:0003071 ! renal system process involved in regulation of systemic arterial blood pressure [Term] id: GO:0003073 name: regulation of systemic arterial blood pressure namespace: biological_process def: "The process that modulates the force with which blood travels through the systemic arterial circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:mtg_cardio] is_a: GO:0008217 ! regulation of blood pressure [Term] id: GO:0003074 name: regulation of diuresis namespace: biological_process def: "Any process that modulates the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0044062 ! regulation of excretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030146 ! diuresis relationship: regulates GO:0030146 ! diuresis [Term] id: GO:0003075 name: renal vasodilation of the peripheral vascular system involved in regulation of systemic arterial blood pressure namespace: biological_process def: "The renal process that modulates the force with which blood travels through the circulatory system, by vasodilation of the peripheral vascular system." [GOC:mtg_cardio] synonym: "renal regulation of systemic arterial blood pressure by vasodilation of the peripheral vascular system" EXACT [GOC:dph, GOC:tb] is_a: GO:0003072 ! renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure [Term] id: GO:0003077 name: negative regulation of diuresis namespace: biological_process def: "Any process that reduces the rate of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] is_a: GO:0003074 ! regulation of diuresis is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030146 ! diuresis relationship: negatively_regulates GO:0030146 ! diuresis [Term] id: GO:0003078 name: regulation of natriuresis namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0044062 ! regulation of excretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030147 ! natriuresis relationship: regulates GO:0030147 ! natriuresis [Term] id: GO:0003079 name: positive regulation of natriuresis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of natriuresis." [GOC:mtg_cardio] is_a: GO:0003078 ! regulation of natriuresis is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030147 ! natriuresis relationship: positively_regulates GO:0030147 ! natriuresis [Term] id: GO:0003080 name: negative regulation of natriuresis namespace: biological_process def: "Any process that stops, prevents, or decreases the frequency, rate, or extent of natriuresis, the process of renal sodium excretion." [GOC:mah] is_a: GO:0003078 ! regulation of natriuresis is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0051048 ! negative regulation of secretion is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030147 ! natriuresis relationship: negatively_regulates GO:0030147 ! natriuresis [Term] id: GO:0003081 name: regulation of systemic arterial blood pressure by renin-angiotensin namespace: biological_process def: "The process by which renin-angiotensin modulates the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "blood pressure regulation by renin-angiotensin" EXACT [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003082 name: positive regulation of renal output by angiotensin namespace: biological_process def: "Any process by which angiotensin directly increases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated positive regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003085 ! negative regulation of systemic arterial blood pressure [Term] id: GO:0003083 name: negative regulation of renal output by angiotensin namespace: biological_process def: "The process by which angiotensin directly decreases the rate of natriuresis and diuresis in the kidney." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] synonym: "angiotensin-mediated negative regulation of renal output" EXACT [GOC:dph, GOC:tb] is_a: GO:0002019 ! regulation of renal output by angiotensin is_a: GO:0003084 ! positive regulation of systemic arterial blood pressure [Term] id: GO:0003084 name: positive regulation of systemic arterial blood pressure namespace: biological_process def: "The process that increases the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045777 ! positive regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003085 name: negative regulation of systemic arterial blood pressure namespace: biological_process def: "The process that reduces the force with which blood travels through the systemic arterial circulatory system." [GOC:mtg_cardio] is_a: GO:0045776 ! negative regulation of blood pressure relationship: part_of GO:0003073 ! regulation of systemic arterial blood pressure [Term] id: GO:0003086 name: regulation of systemic arterial blood pressure by local renal renin-angiotensin namespace: biological_process def: "The process by which angiotensinogen metabolites in the kidney modulate the force with which blood passes through the renal circulatory system. The process begins when renin cleaves angiotensinogen." [GOC:mtg_cardio] is_a: GO:0003081 ! regulation of systemic arterial blood pressure by renin-angiotensin [Term] id: GO:0003087 name: positive regulation of the force of heart contraction by neuronal epinephrine namespace: biological_process def: "The process by which the release of epinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal epinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline" RELATED [] synonym: "positive regulation of heart contraction by neuronal epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003090 ! positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine [Term] id: GO:0003088 name: positive regulation of the force of heart contraction by circulating epinephrine namespace: biological_process def: "The process by which the secretion of epinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline" RELATED [] synonym: "increased force of heart contraction by epinephrine in the bloodstream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine" RELATED [] is_a: GO:0003059 ! positive regulation of the force of heart contraction by epinephrine relationship: part_of GO:0003089 ! positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine [Term] id: GO:0003089 name: positive regulation of the force of heart contraction by circulating epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine in the bloodstream." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by circulating epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "increased force of heart contraction by epinephrine-norepinephrine in the blood stream" EXACT [] synonym: "positive regulation of heart contraction by circulating adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by circulating epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003090 name: positive regulation of the force of heart contraction by neuronal epinephrine-norepinephrine namespace: biological_process def: "Any process that increases the force with which the cardiac muscles of the heart pump blood through the circulatory system as a result of the presence of epinephrine or norepinephrine released from the nerve endings." [GOC:mtg_cardio] synonym: "increased force of heart contraction by epinephrine-norepinephrine released from the nerve endings" EXACT [] synonym: "increased force of heart contraction by neuronal adrenaline-noradrenaline" EXACT [] synonym: "increased force of heart contraction by neuronal epinephrine-norepinephrine" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of heart contraction by adrenaline-noradrenaline" RELATED [] synonym: "positive regulation of heart contraction by epinephrine-norepinephrine" RELATED [] is_a: GO:0001997 ! positive regulation of the force of heart contraction by epinephrine-norepinephrine [Term] id: GO:0003091 name: renal water homeostasis namespace: biological_process def: "Renal process involved in the maintenance of internal steady-state of water in the body." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0050891 ! multicellular organismal water homeostasis [Term] id: GO:0003092 name: renal water retention namespace: biological_process def: "The process whereby renal water excretion is decreased." [GOC:mtg_cardio] synonym: "negative regulation of renal water excretion" EXACT [] is_a: GO:0003077 ! negative regulation of diuresis [Term] id: GO:0003093 name: regulation of glomerular filtration namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glomerular filtration. Glomerular filtration is the process whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003094 ! glomerular filtration relationship: regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003094 name: glomerular filtration namespace: biological_process def: "The process whereby plasma is filtered through the glomerular membrane which consists of capillary endothelial cells, the basement membrane, and epithelial cells. The glomerular filtrate is the same as plasma except it has no significant amount of protein." [GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] is_a: GO:0003014 ! renal system process [Term] id: GO:0003095 name: pressure natriuresis namespace: biological_process def: "The process by which the volume of blood increases renal pressure and results in an increase in natriuresis and diuresis." [GOC:mtg_cardio] is_a: GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003096 name: renal sodium ion transport namespace: biological_process def: "The directed movement of sodium ions (Na+) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006814 ! sodium ion transport relationship: part_of GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003097 name: renal water transport namespace: biological_process def: "The directed movement of water (H2O) by the kidney." [GOC:mtg_cardio] is_a: GO:0003014 ! renal system process is_a: GO:0006833 ! water transport relationship: part_of GO:0001977 ! renal system process involved in regulation of blood volume [Term] id: GO:0003098 name: tubuloglomerular feedback namespace: biological_process def: "The process by which blood volume is regulated due to a change in the rate of glomerular filtration. This is accomplished by a feedback mechanism that senses changes in the juxtaglomerular apparatus." [GOC:mtg_cardio] xref: Wikipedia:Tubuloglomerular_feedback is_a: GO:0001977 ! renal system process involved in regulation of blood volume relationship: part_of GO:0003093 ! regulation of glomerular filtration [Term] id: GO:0003099 name: positive regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which increases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "positive regulation of the force of heart muscle contraction by chemical signal" EXACT [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0003100 name: regulation of systemic arterial blood pressure by endothelin namespace: biological_process def: "The process by which endothelin modulates the force with which blood passes through the circulatory system. Endothelin is a hormone that is released by the endothelium, and it is a vasoconstrictor." [GOC:mtg_cardio] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003101 name: regulation of systemic arterial blood pressure by circulatory epinephrine-norepinephrine namespace: biological_process def: "The process by which epinephrine-norepinephrine modulate the force with which blood passes through the circulatory system." [GOC:mtg_cardio] synonym: "regulation of blood pressure by circulating adrenaline-noradrenaline" RELATED [] is_a: GO:0001990 ! regulation of systemic arterial blood pressure by hormone [Term] id: GO:0003102 name: positive regulation of diuresis by angiotensin namespace: biological_process def: "Any process mediated by angiotensin that increases the rate of diuresis." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin-mediated positive regulation of diuresis" EXACT [GOC:dph, GOC:tb] is_a: GO:0003082 ! positive regulation of renal output by angiotensin is_a: GO:0003103 ! positive regulation of diuresis [Term] id: GO:0003103 name: positive regulation of diuresis namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of diuresis. Diuresis is the process of renal water excretion." [GOC:mtg_cardio] is_a: GO:0003074 ! regulation of diuresis is_a: GO:0051047 ! positive regulation of secretion is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030146 ! diuresis relationship: positively_regulates GO:0030146 ! diuresis [Term] id: GO:0003104 name: positive regulation of glomerular filtration namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003094 ! glomerular filtration relationship: positively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003105 name: negative regulation of glomerular filtration namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of glomerular filtration. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:mtg_cardio] is_a: GO:0003093 ! regulation of glomerular filtration is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003094 ! glomerular filtration relationship: negatively_regulates GO:0003094 ! glomerular filtration [Term] id: GO:0003106 name: regulation of glomerular filtration by angiotensin namespace: biological_process def: "The process by which angiotensin directly decreases the rate of glomerular filtration in the kidney. Glomerular filtration is the processs whereby blood is filtered by the glomerulus into the renal tubule." [GOC:dph, GOC:mah, GOC:tb] synonym: "angiotensin-mediated regulation of glomerular filtration" EXACT [GOC:dph, GOC:tb] is_a: GO:0003083 ! negative regulation of renal output by angiotensin relationship: part_of GO:0003105 ! negative regulation of glomerular filtration [Term] id: GO:0003107 name: positive regulation of natriuresis by angiotensin namespace: biological_process def: "The process by which angiotensin increases the rate of natriuresis indirectly via diuresis. Natriuresis is the process of renal sodium excretion." [GOC:dph, GOC:mtg_cardio, GOC:tb] synonym: "angiotensin-mediated positive regulation of natriuresis" EXACT [GOC:dph, GOC:tb] is_a: GO:0003079 ! positive regulation of natriuresis is_a: GO:0003102 ! positive regulation of diuresis by angiotensin [Term] id: GO:0003108 name: negative regulation of the force of heart contraction by chemical signal namespace: biological_process def: "Any process which decreases the force of heart muscle contraction mediated by chemical signaling, hormonal, autocrine or paracrine." [GOC:mtg_cardio] synonym: "negative regulation of the force of heart muscle contraction by chemical signal" RELATED [] is_a: GO:0003057 ! regulation of the force of heart contraction by chemical signal is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0003109 name: positive regulation of the force of heart contraction by circulating norepinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine into the bloodstream modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by circulating noradrenaline" RELATED [] synonym: "increased force of heart contraction by circulating norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003110 name: positive regulation of the force of heart contraction by neuronal norepinephrine namespace: biological_process def: "The process by which the release of norepinephrine from nerve endings modulates the force of heart muscle contraction." [GOC:mtg_cardio] synonym: "increased force of heart contraction by neuronal noradrenaline" RELATED [] synonym: "increased force of heart contraction by neuronal norepinephrine" EXACT [GOC:dph, GOC:tb] is_a: GO:0003061 ! positive regulation of the force of heart contraction by norepinephrine [Term] id: GO:0003111 name: positive regulation of heart rate by circulating epinephrine namespace: biological_process def: "The process by which the secretion of epinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003112 name: positive regulation of heart rate by neuronal epinephrine namespace: biological_process def: "The process by which the secretion of epinephrine from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal adrenaline" EXACT [] is_a: GO:0003065 ! positive regulation of heart rate by epinephrine [Term] id: GO:0003113 name: positive regulation of heart rate by neuronal norepinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine released from nerve endings increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by neuronal noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003114 name: positive regulation of heart rate by circulating norepinephrine namespace: biological_process def: "The process by which the secretion of norepinephrine into the bloodstream increases the rate of heart muscle contraction." [GOC:mtg_cardio] synonym: "positive regulation of heart rate by circulating noradrenaline" EXACT [] is_a: GO:0003066 ! positive regulation of heart rate by norepinephrine [Term] id: GO:0003115 name: regulation of vasoconstriction by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003116 name: regulation of vasoconstriction by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] is_a: GO:0019229 ! regulation of vasoconstriction [Term] id: GO:0003117 name: regulation of vasoconstriction by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003118 name: regulation of vasoconstriction by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal noradrenaline" EXACT [] is_a: GO:0003116 ! regulation of vasoconstriction by norepinephrine [Term] id: GO:0003119 name: regulation of vasoconstriction by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by neuronal adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003120 name: regulation of vasoconstriction by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of reductions in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasoconstriction by circulating adrenaline" EXACT [] is_a: GO:0003115 ! regulation of vasoconstriction by epinephrine [Term] id: GO:0003121 name: regulation of vasodilation by epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by adrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003122 name: regulation of vasodilation by norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream or released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by noradrenaline" EXACT [] is_a: GO:0042312 ! regulation of vasodilation [Term] id: GO:0003123 name: regulation of vasodilation by circulating epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of epinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003124 name: regulation of vasodilation by neuronal epinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of epinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal adrenaline" EXACT [] is_a: GO:0003121 ! regulation of vasodilation by epinephrine [Term] id: GO:0003125 name: regulation of vasodilation by circulating norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of secretion of norepinephrine into the bloodstream." [GOC:mtg_cardio] synonym: "regulation of vasodilation by circulating noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003126 name: regulation of vasodilation by neuronal norepinephrine namespace: biological_process def: "Any process that modulates the frequency, rate or extent of increases in the diameter of blood vessels as a result of norepinephrine released by nerve endings." [GOC:mtg_cardio] synonym: "regulation of vasodilation by neuronal noradrenaline" EXACT [] is_a: GO:0003122 ! regulation of vasodilation by norepinephrine [Term] id: GO:0003127 name: detection of nodal flow namespace: biological_process def: "The series of events by which an endogenous stimulus is received by a cilium on a cell and converted to a molecular signal contributing to left/right asymmetry." [GOC:mtg_heart] is_a: GO:0009726 ! detection of endogenous stimulus relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: tanyaberardini creation_date: 2009-09-22T02:45:48Z [Term] id: GO:0003128 name: heart field specification namespace: biological_process def: "The process by which a specific region of the lateral mesoderm is delineated into the area in which the heart will develop." [GOC:mtg_heart] is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0060914 ! heart formation created_by: tanyaberardini creation_date: 2009-09-22T02:56:05Z [Term] id: GO:0003129 name: heart induction namespace: biological_process def: "The close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart." [GOC:mtg_heart] is_a: GO:0001759 ! induction of an organ relationship: positively_regulates GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T02:58:41Z [Term] id: GO:0003130 name: BMP signaling pathway involved in heart induction namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to heart induction." [GOC:mtg_heart] is_a: GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction is_a: GO:0030509 ! BMP signaling pathway created_by: tanyaberardini creation_date: 2009-09-22T03:02:00Z [Term] id: GO:0003131 name: mesodermal-endodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling created_by: tanyaberardini creation_date: 2009-09-22T03:07:34Z [Term] id: GO:0003132 name: mesodermal-endodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from mesodermal cells to endodermal cells that contributes to heart induction." [GOC:mtg_heart] is_a: GO:0003131 ! mesodermal-endodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:08:52Z [Term] id: GO:0003133 name: endodermal-mesodermal cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells." [GOC:mtg_heart] is_a: GO:0007267 ! cell-cell signaling created_by: tanyaberardini creation_date: 2009-09-22T03:10:29Z [Term] id: GO:0003134 name: endodermal-mesodermal cell signaling involved in heart induction namespace: biological_process def: "Any process that mediates the transfer of information from endodermal cells to mesodermal cells that contributes to heart induction." [GOC:mtg_heart] is_a: GO:0003133 ! endodermal-mesodermal cell signaling is_a: GO:0045168 ! cell-cell signaling involved in cell fate commitment relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:11:17Z [Term] id: GO:0003135 name: fibroblast growth factor receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to heart induction." [GOC:mtg_heart] is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:17:49Z [Term] id: GO:0003136 name: canonical Wnt receptor signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes involved in heart induction." [GOC:mtg_heart] is_a: GO:0003134 ! endodermal-mesodermal cell signaling involved in heart induction is_a: GO:0003306 ! Wnt receptor signaling pathway involved in heart development is_a: GO:0060070 ! canonical Wnt receptor signaling pathway created_by: tanyaberardini creation_date: 2009-09-22T03:26:17Z [Term] id: GO:0003137 name: Notch signaling pathway involved in heart induction namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction." [GOC:mtg_heart] is_a: GO:0007219 ! Notch signaling pathway relationship: part_of GO:0003129 ! heart induction created_by: tanyaberardini creation_date: 2009-09-22T03:28:42Z [Term] id: GO:0003138 name: primary heart field specification namespace: biological_process def: "The process by which a specific region of the lateral mesoderm is delineated into the area which will form the primary beating heart tube." [GOC:mtg_heart] is_a: GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T03:47:24Z [Term] id: GO:0003139 name: secondary heart field specification namespace: biological_process def: "The process by which a specific region of the lateral mesoderm is delineated into the area which will form the majority of the mesodermal component of the right ventricle, arterial and venous poles." [GOC:mtg_heart] synonym: "anterior heart field specification" NARROW [GOC:mtg_heart] synonym: "second heart field specification" EXACT [GOC:mtg_heart] is_a: GO:0003128 ! heart field specification created_by: tanyaberardini creation_date: 2009-09-22T03:47:56Z [Term] id: GO:0003140 name: determination of left/right asymmetry in lateral mesoderm namespace: biological_process def: "The establishment of the lateral mesoderm with respect to the left and right halves." [GOC:mtg_heart] is_a: GO:0007368 ! determination of left/right symmetry relationship: part_of GO:0048368 ! lateral mesoderm development created_by: tanyaberardini creation_date: 2009-09-22T03:58:29Z [Term] id: GO:0003141 name: transforming growth factor beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to lateral mesoderm left/right asymmetry determination." [GOC:mtg_heart] synonym: "TGF-beta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGF-beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signaling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "TGFbeta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] synonym: "transforming growth factor beta receptor signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway involved in determination of lateral mesoderm left/right asymmetry" EXACT [] is_a: GO:0035463 ! transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm created_by: tanyaberardini creation_date: 2009-09-22T04:03:22Z [Term] id: GO:0003142 name: cardiogenic plate morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the cardiogenic plate are generated and organized. The cardiogenic plate is the first recognizable structure derived from the heart field." [GOC:mtg_heart] synonym: "cardiac crescent morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T04:12:18Z [Term] id: GO:0003143 name: embryonic heart tube morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the embryonic heart tube are generated and organized. Morphogenesis pertains to the creation of form. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060562 ! epithelial tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0035050 ! embryonic heart tube development created_by: tanyaberardini creation_date: 2009-09-22T04:21:17Z [Term] id: GO:0003144 name: embryonic heart tube formation namespace: biological_process def: "The process that gives rise to the embryonic heart tube. This process pertains to the initial formation of a structure from unspecified parts. The embryonic heart tube is an epithelial tube that will give rise to the mature heart." [GOC:mtg_heart] is_a: GO:0001838 ! embryonic epithelial tube formation relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T04:22:34Z [Term] id: GO:0003145 name: embryonic heart tube formation via epithelial folding namespace: biological_process def: "The process that gives rise to the embryonic heart tube by the cells of the heart field along a linear axis." [GOC:mtg_heart] is_a: GO:0003144 ! embryonic heart tube formation created_by: tanyaberardini creation_date: 2009-09-22T04:26:03Z [Term] id: GO:0003146 name: heart jogging namespace: biological_process def: "The morphogenetic process by which the heart cone is displaced to the left with respect to the vector of the anterior-posterior axis." [GOC:mtg_heart, PMID:9334285] synonym: "cardiac jogging" EXACT [GOC:mtg_heart] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003143 ! embryonic heart tube morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T06:11:41Z [Term] id: GO:0003147 name: neural crest cell migration involved in heart formation namespace: biological_process def: "The characteristic movement of a cell from the dorsal ridge of the neural tube to a variety of locations in a vertebrate embryo that contributes to heart formation." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation created_by: tanyaberardini creation_date: 2009-09-22T04:29:55Z [Term] id: GO:0003148 name: outflow tract septum morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the outflow tract septum are generated and organized. Morphogenesis pertains to the creation of form. The outflow tract septum is a partition in the outflow tract." [GOC:mtg_heart] is_a: GO:0060411 ! cardiac septum morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:51:01Z [Term] id: GO:0003149 name: membranous septum morphogenesis namespace: biological_process def: "The process by which the membranous septum is generated and organized. The membranous septum is the upper part of ventricular septum. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:51:41Z [Term] id: GO:0003150 name: muscular septum morphogenesis namespace: biological_process def: "The process by which the muscular septum is generated and organized. The muscular septum is the lower part of the ventricular septum." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0060412 ! ventricular septum morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:53:28Z [Term] id: GO:0003151 name: outflow tract morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the outflow tract are generated and organized. Morphogenesis pertains to the creation of form. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: tanyaberardini creation_date: 2009-09-22T07:59:24Z [Term] id: GO:0003152 name: morphogenesis of an epithelial fold involved in embryonic heart tube formation namespace: biological_process def: "The morphogenetic process by which an epithelial sheet bends along a linear axis that contributes to embryonic heart tube formation." [GOC:mtg_heart] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tanyaberardini creation_date: 2009-09-23T10:10:24Z [Term] id: GO:0003153 name: closure of embryonic heart tube namespace: biological_process def: "Creation of the central hole of the embryonic heart tube by sealing the edges of an epithelial fold." [GOC:mtg_heart] is_a: GO:0060606 ! tube closure relationship: part_of GO:0003145 ! embryonic heart tube formation via epithelial folding created_by: tanyaberardini creation_date: 2009-09-23T10:14:54Z [Term] id: GO:0003154 name: BMP signaling pathway involved in determination of left/right symmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of left/right symmetry." [GOC:mtg_heart] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0007368 ! determination of left/right symmetry created_by: tanyaberardini creation_date: 2009-09-24T05:34:57Z [Term] id: GO:0003155 name: BMP signaling pathway involved in determination of lateral mesoderm left/right asymmetry namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the determination of lateral mesoderm left/right asymmetry." [GOC:mtg_heart] synonym: "BMP signaling pathway involved in lateral mesoderm left/right asymmetry determination" EXACT [] is_a: GO:0003154 ! BMP signaling pathway involved in determination of left/right symmetry relationship: part_of GO:0003140 ! determination of left/right asymmetry in lateral mesoderm created_by: tanyaberardini creation_date: 2009-09-24T05:42:17Z [Term] id: GO:0003156 name: regulation of organ formation namespace: biological_process def: "Any process that modulates the rate, frequency or extent of organ formation. Organ formation is the process pertaining to the initial formation of an organ from unspecified parts. The process begins with the specific processes that contribute to the appearance of the discrete structure, such as inductive events, and ends when the structural rudiment of the organ is recognizable, such as a condensation of mesenchymal cells into the organ rudiment." [GOC:dph, GOC:mtg_heart, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048645 ! organ formation relationship: regulates GO:0048645 ! organ formation created_by: tanyaberardini creation_date: 2009-09-30T11:21:09Z [Term] id: GO:0003157 name: endocardium development namespace: biological_process def: "The process whose specific outcome is the progression of the endocardium over time, from its formation to the mature structure. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-01T12:42:27Z [Term] id: GO:0003158 name: endothelium development namespace: biological_process def: "The process whose specific outcome is the progression of an endothelium over time, from its formation to the mature structure. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development created_by: dph creation_date: 2009-10-01T12:50:57Z [Term] id: GO:0003159 name: morphogenesis of an endothelium namespace: biological_process def: "The process by which the anatomical structure of an endothelium is generated and organized. An endothelium is an epithelium that lines an anatomical structure." [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0003158 ! endothelium development created_by: dph creation_date: 2009-10-01T01:34:06Z [Term] id: GO:0003160 name: endocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structure of the endocardium is generated and organized. The endocardium is an anatomical structure comprised of an endothelium and an extracellular matrix that forms the innermost layer of tissue of the heart, and lines the heart chambers." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003157 ! endocardium development created_by: dph creation_date: 2009-10-01T01:37:26Z [Term] id: GO:0003161 name: cardiac conduction system development namespace: biological_process def: "The process whose specific outcome is the progression of the cardiac conduction system over time, from its formation to the mature structure. The cardiac conduction system consists of specialized cardiomyocytes that regulate the frequency of heart beat." [GOC:mtg_heart] synonym: "cardiac impulse conducting system development" EXACT [GOC:mtg_heart] synonym: "heart conduction system development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-01T01:57:16Z [Term] id: GO:0003162 name: atrioventricular node development namespace: biological_process def: "The process whose specific outcome is the progression of the atrioventricular (AV) node over time, from its formation to the mature structure. The AV node is part of the cardiac conduction system that controls the timing of ventricle contraction by receiving electrical signals from the sinoatrial (SA) node and relaying them to the His-Purkinje system." [GOC:mtg_heart] synonym: "AV node development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:05:13Z [Term] id: GO:0003163 name: sinoatrial node development namespace: biological_process def: "The process whose specific outcome is the progression of the sinoatrial (SA) node over time, from its formation to the mature structure. The SA node is part of the cardiac conduction system that controls the timing of heart muscle contraction. It relays electrical signals to the AV node." [GOC:mtg_heart] synonym: "SA node development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:06:09Z [Term] id: GO:0003164 name: His-Purkinje system development namespace: biological_process def: "The process whose specific outcome is the progression of the His-Purkinje system over time, from its formation to the mature structure. The His-Purkinje system receives signals from the AV node and is composed of the fibers that regulate cardiac muscle contraction in the ventricles." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003161 ! cardiac conduction system development created_by: dph creation_date: 2009-10-01T02:07:12Z [Term] id: GO:0003165 name: cardiac Purkinje fiber development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac Purkinje fiber over time, from its formation to the mature structure. The cardiac Purkinje fiber is part of the cardiac conduction system that receives signals from the bundle of His and innervates the ventricular cardiac muscle." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development created_by: dph creation_date: 2009-10-01T02:07:50Z [Term] id: GO:0003166 name: bundle of His development namespace: biological_process def: "The process whose specific outcome is the progression of the bundle of His over time, from its formation to the mature structure. The bundle of His is part of the His-Purkinje system that transmits signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "atrioventricular bundle development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003164 ! His-Purkinje system development created_by: dph creation_date: 2009-10-01T02:08:43Z [Term] id: GO:0003167 name: atrioventricular bundle cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cell of the atrioventricular bundle. These cells are specialized cardiomyocytes that transmit signals from the AV node to the cardiac Purkinje fibers." [GOC:mtg_heart] synonym: "AV bundle cell differentiation" EXACT [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003166 ! bundle of His development created_by: dph creation_date: 2009-10-01T02:48:23Z [Term] id: GO:0003168 name: cardiac Purkinje fiber cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac Purkinje fiber cell. These cells are specialized cardiomyocytes that receive signals from the bundle of His and innervate the ventricular cardiac muscle." [GOC:mtg_heart] is_a: GO:0060932 ! His-Purkinje system cell differentiation relationship: part_of GO:0003165 ! cardiac Purkinje fiber development created_by: dph creation_date: 2009-10-01T02:49:54Z [Term] id: GO:0003169 name: coronary vein morphogenesis namespace: biological_process def: "The process by which the anatomical structures of veins of the heart are generated and organized." [GOC:mtg_heart] is_a: GO:0048845 ! venous blood vessel morphogenesis is_a: GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-08T10:45:41Z [Term] id: GO:0003170 name: heart valve development namespace: biological_process def: "The progression of a heart valve over time, from its formation to the mature structure. A heart valve is a structure that restricts the flow of blood to different regions of the heart and forms from an endocardial cushion." [GOC:mtg_heart] synonym: "cardiac valve development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-08T10:50:09Z [Term] id: GO:0003171 name: atrioventricular valve development namespace: biological_process def: "The progression of the atrioventricular valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "AV valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:14:21Z [Term] id: GO:0003172 name: sinoatrial valve development namespace: biological_process def: "The progression of the sinoatrial valve over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "SA valve development" EXACT [GOC:mah] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:15:39Z [Term] id: GO:0003173 name: ventriculo bulbo valve development namespace: biological_process def: "The progression of the ventriculo bulbo valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:16:25Z [Term] id: GO:0003174 name: mitral valve development namespace: biological_process def: "The progression of the mitral valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:17:22Z [Term] id: GO:0003175 name: tricuspid valve development namespace: biological_process def: "The progression of the tricuspid valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:18:12Z [Term] id: GO:0003176 name: aortic valve development namespace: biological_process def: "The progression of the aortic valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:18:55Z [Term] id: GO:0003177 name: pulmonary valve development namespace: biological_process def: "The progression of the pulmonary valve over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:19:44Z [Term] id: GO:0003178 name: coronary sinus valve development namespace: biological_process def: "The progression of the valve of the coronary sinus over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:21:43Z [Term] id: GO:0003179 name: heart valve morphogenesis namespace: biological_process def: "The process by which the structure of a heart valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-08T11:23:48Z [Term] id: GO:0003180 name: aortic valve morphogenesis namespace: biological_process def: "The process by which the structure of the aortic valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003176 ! aortic valve development created_by: dph creation_date: 2009-10-08T11:29:42Z [Term] id: GO:0003181 name: atrioventricular valve morphogenesis namespace: biological_process def: "The process by which the structure of the atrioventricular valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] synonym: "AV valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003171 ! atrioventricular valve development created_by: dph creation_date: 2009-10-08T11:31:59Z [Term] id: GO:0003182 name: coronary sinus valve morphogenesis namespace: biological_process def: "The process by which the structure of the coronary sinus valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003178 ! coronary sinus valve development created_by: dph creation_date: 2009-10-08T11:33:31Z [Term] id: GO:0003183 name: mitral valve morphogenesis namespace: biological_process def: "The process by which the structure of the mitral valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003174 ! mitral valve development created_by: dph creation_date: 2009-10-08T12:02:01Z [Term] id: GO:0003184 name: pulmonary valve morphogenesis namespace: biological_process def: "The process by which the structure of the pulmonary valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003177 ! pulmonary valve development created_by: dph creation_date: 2009-10-08T12:03:35Z [Term] id: GO:0003185 name: sinoatrial valve morphogenesis namespace: biological_process def: "The process by which the structure of the sinoatrial valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] synonym: "SA valve morphogenesis" EXACT [GOC:mah] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003172 ! sinoatrial valve development created_by: dph creation_date: 2009-10-08T12:04:52Z [Term] id: GO:0003186 name: tricuspid valve morphogenesis namespace: biological_process def: "The process by which the structure of the tricuspid valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003175 ! tricuspid valve development created_by: dph creation_date: 2009-10-08T12:05:45Z [Term] id: GO:0003187 name: ventriculo bulbo valve morphogenesis namespace: biological_process def: "The process by which the structure of the ventriculo bulbo valve is generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_heart] is_a: GO:0003179 ! heart valve morphogenesis relationship: part_of GO:0003173 ! ventriculo bulbo valve development created_by: dph creation_date: 2009-10-08T12:07:00Z [Term] id: GO:0003188 name: heart valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a heart valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-08T12:20:15Z [Term] id: GO:0003189 name: aortic valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the aortic valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003180 ! aortic valve morphogenesis created_by: dph creation_date: 2009-10-08T01:05:44Z [Term] id: GO:0003190 name: atrioventricular valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the atrioventricular valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "AV valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003181 ! atrioventricular valve morphogenesis created_by: dph creation_date: 2009-10-08T01:07:28Z [Term] id: GO:0003191 name: coronary sinus valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the coronary sinus valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003182 ! coronary sinus valve morphogenesis created_by: dph creation_date: 2009-10-08T01:09:04Z [Term] id: GO:0003192 name: mitral valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the mitral valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003183 ! mitral valve morphogenesis created_by: dph creation_date: 2009-10-08T01:10:19Z [Term] id: GO:0003193 name: pulmonary valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the pulmonary valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003184 ! pulmonary valve morphogenesis created_by: dph creation_date: 2009-10-08T01:11:20Z [Term] id: GO:0003194 name: sinoatrial valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinoatrial valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] synonym: "SA valve formation" EXACT [GOC:mah] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003185 ! sinoatrial valve morphogenesis created_by: dph creation_date: 2009-10-08T01:12:45Z [Term] id: GO:0003195 name: tricuspid valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the tricuspid valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003186 ! tricuspid valve morphogenesis created_by: dph creation_date: 2009-10-08T01:14:40Z [Term] id: GO:0003196 name: ventriculo bulbo valve formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the ventriculo bulbo valve from unspecified parts. This process begins with the specific processes that contribute to the appearance of the discrete structure and ends when the structural rudiment is recognizable." [GOC:mtg_heart] is_a: GO:0003188 ! heart valve formation relationship: part_of GO:0003187 ! ventriculo bulbo valve morphogenesis created_by: dph creation_date: 2009-10-08T01:16:02Z [Term] id: GO:0003197 name: endocardial cushion development namespace: biological_process def: "The progression of a cardiac cushion over time, from its initial formation to the mature structure. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-08T01:17:43Z [Term] id: GO:0003198 name: epithelial to mesenchymal transition involved in endocardial cushion formation namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the endocardial cushion." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-08T01:27:42Z [Term] id: GO:0003199 name: endocardial cushion to mesenchymal transition involved in valve formation namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of a cardiac valve." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003188 ! heart valve formation created_by: dph creation_date: 2009-10-08T01:31:21Z [Term] id: GO:0003200 name: endocardial cushion to mesenchymal transition involved in heart chamber septation namespace: biological_process def: "A transition where an endocardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the formation of the heart septum." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060411 ! cardiac septum morphogenesis created_by: dph creation_date: 2009-10-08T01:34:31Z [Term] id: GO:0003201 name: epithelial to mesenchymal transition involved in coronary vasculature morphogenesis namespace: biological_process def: "A transition where a cardiac epithelial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will contribute to the shaping of the coronary vasculature." [GOC:mtg_heart] is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0060977 ! coronary vasculature morphogenesis created_by: dph creation_date: 2009-10-08T01:36:54Z [Term] id: GO:0003202 name: endocardial cushion to mesenchymal transition involved in cardiac skeleton development namespace: biological_process def: "A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell that will give rise to the cardiac skeleton." [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development is_a: GO:0060317 ! cardiac epithelial to mesenchymal transition relationship: part_of GO:0003204 ! cardiac skeleton development created_by: dph creation_date: 2009-10-08T01:39:57Z [Term] id: GO:0003203 name: endocardial cushion morphogenesis namespace: biological_process def: "The process by which the anatomical structure of the endocardial cushion is generated and organized. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0072132 ! mesenchyme morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003197 ! endocardial cushion development created_by: dph creation_date: 2009-10-08T01:43:22Z [Term] id: GO:0003204 name: cardiac skeleton development namespace: biological_process def: "The progression of the cardiac skeleton over time, from its formation to the mature structure. The cardiac skeleton is a specialized extracellular matrix that separates the atria from the ventricles and provides physical support for the heart." [GOC:mtg_heart] synonym: "heart fibrous skeleton development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-13T09:05:04Z [Term] id: GO:0003205 name: cardiac chamber development namespace: biological_process def: "The progression of a cardiac chamber over time, from its formation to the mature structure. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] xref: GOC:mtg_heart is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-13T09:11:18Z [Term] id: GO:0003206 name: cardiac chamber morphogenesis namespace: biological_process def: "The process by which a cardiac chamber is generated and organized. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T09:14:51Z [Term] id: GO:0003207 name: cardiac chamber formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac chamber from unspecified parts. A cardiac chamber is an enclosed cavity within the heart." [GOC:mtg_heart] synonym: "heart chamber formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis created_by: dph creation_date: 2009-10-13T09:29:13Z [Term] id: GO:0003208 name: cardiac ventricle morphogenesis namespace: biological_process def: "The process by which the cardiac ventricle is generated and organized. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003231 ! cardiac ventricle development created_by: dph creation_date: 2009-10-13T09:38:44Z [Term] id: GO:0003209 name: cardiac atrium morphogenesis namespace: biological_process def: "The process by which the cardiac atrium is generated and organized. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003230 ! cardiac atrium development created_by: dph creation_date: 2009-10-13T09:39:44Z [Term] id: GO:0003210 name: cardiac atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac atrium from unspecified parts. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:44:25Z [Term] id: GO:0003211 name: cardiac ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac ventricle from unspecified parts. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:46:27Z [Term] id: GO:0003212 name: cardiac left atrium morphogenesis namespace: biological_process def: "The process by which the left cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:48:16Z [Term] id: GO:0003213 name: cardiac right atrium morphogenesis namespace: biological_process def: "The process by which the right cardiac atrium is generated and organized." [GOC:mtg_heart] is_a: GO:0003209 ! cardiac atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:49:03Z [Term] id: GO:0003214 name: cardiac left ventricle morphogenesis namespace: biological_process def: "The process by which the left cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:50:08Z [Term] id: GO:0003215 name: cardiac right ventricle morphogenesis namespace: biological_process def: "The process by which the right cardiac ventricle is generated and organized." [GOC:mtg_heart] is_a: GO:0003208 ! cardiac ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:50:57Z [Term] id: GO:0003216 name: cardiac left atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003212 ! cardiac left atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:52:31Z [Term] id: GO:0003217 name: cardiac right atrium formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a cardiac right atrium from unspecified parts." [GOC:mtg_heart] is_a: GO:0003210 ! cardiac atrium formation relationship: part_of GO:0003213 ! cardiac right atrium morphogenesis created_by: dph creation_date: 2009-10-13T09:53:12Z [Term] id: GO:0003218 name: cardiac left ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a left cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:54:33Z [Term] id: GO:0003219 name: cardiac right ventricle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of a right cardiac ventricle from unspecified parts." [GOC:mtg_heart] is_a: GO:0003211 ! cardiac ventricle formation relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis created_by: dph creation_date: 2009-10-13T09:55:38Z [Term] id: GO:0003220 name: left ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process by which the anatomical structures of left cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "left ventricular myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T10:18:05Z [Term] id: GO:0003221 name: right ventricular cardiac muscle tissue morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the right cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] synonym: "right ventricle myocardium morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T10:26:33Z [Term] id: GO:0003222 name: ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the trabecular cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T10:33:00Z [Term] id: GO:0003223 name: ventricular compact myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the compact cardiac ventricle muscle are generated and organized." [GOC:mtg_heart] is_a: GO:0055010 ! ventricular cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T10:34:21Z [Term] id: GO:0003224 name: left ventricular compact myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of cardiac left ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:43:36Z [Term] id: GO:0003225 name: left ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of cardiac left ventricular trabecular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003220 ! left ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:45:09Z [Term] id: GO:0003226 name: right ventricular compact myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the right ventricular compact myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003223 ! ventricular compact myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:48:42Z [Term] id: GO:0003227 name: right ventricular trabecular myocardium morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the right ventricular myocardium are generated and organized." [GOC:mtg_heart] is_a: GO:0003221 ! right ventricular cardiac muscle tissue morphogenesis is_a: GO:0003222 ! ventricular trabecular myocardium morphogenesis created_by: dph creation_date: 2009-10-13T10:50:59Z [Term] id: GO:0003228 name: atrial cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of cardiac muscle of the atrium over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "atrial myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development created_by: dph creation_date: 2009-10-13T10:53:18Z [Term] id: GO:0003229 name: ventricular cardiac muscle tissue development namespace: biological_process def: "The process whose specific outcome is the progression of ventricular cardiac muscle over time, from its formation to the mature structure." [GOC:mtg_heart] synonym: "ventricular myocardium development" EXACT [GOC:mtg_heart] is_a: GO:0048738 ! cardiac muscle tissue development created_by: dph creation_date: 2009-10-13T10:56:01Z [Term] id: GO:0003230 name: cardiac atrium development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac atrium over time, from its formation to the mature structure. A cardiac atrium receives blood from a vein and pumps it to a cardiac ventricle." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:02:07Z [Term] id: GO:0003231 name: cardiac ventricle development namespace: biological_process def: "The process whose specific outcome is the progression of a cardiac ventricle over time, from its formation to the mature structure. A cardiac ventricle receives blood from a cardiac atrium and pumps it out of the heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:03:16Z [Term] id: GO:0003232 name: bulbus arteriosus development namespace: biological_process def: "The process whose specific outcome is the progression of the bulbus arteriosus over time, from its formation to the mature structure. The bulbus arteriosus is an elastic heart chamber." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:05:36Z [Term] id: GO:0003233 name: bulbus arteriosus morphogenesis namespace: biological_process def: "The process by which the bulbus arteriosus is generated and organized. The bulbus arteriosus is an elastic cardiac chamber." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003232 ! bulbus arteriosus development created_by: dph creation_date: 2009-10-13T11:07:30Z [Term] id: GO:0003234 name: bulbus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the bulbus arteriosus from unspecified parts. The bulbus arteriosus is an elastic chamber of the heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003233 ! bulbus arteriosus morphogenesis created_by: dph creation_date: 2009-10-13T11:10:02Z [Term] id: GO:0003235 name: sinus venosus development namespace: biological_process def: "The progression of the sinus venosus over time, from its formation to the mature structure. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:12:34Z [Term] id: GO:0003236 name: sinus venosus morphogenesis namespace: biological_process def: "The process by which the sinus venosus is generated and organized. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003235 ! sinus venosus development created_by: dph creation_date: 2009-10-13T11:16:52Z [Term] id: GO:0003237 name: sinus venosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the sinus venosus from unspecified parts. The sinus venosus is a heart chamber attached to the atrium on the venous side of the embryonic heart." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003236 ! sinus venosus morphogenesis created_by: dph creation_date: 2009-10-13T11:18:34Z [Term] id: GO:0003238 name: conus arteriosus development namespace: biological_process def: "The progression of the conus arteriosus over time, from its formation to the mature structure. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-13T11:20:57Z [Term] id: GO:0003239 name: conus arteriosus morphogenesis namespace: biological_process def: "The process by which the conus arteriosus is generated and organized. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003206 ! cardiac chamber morphogenesis relationship: part_of GO:0003238 ! conus arteriosus development created_by: dph creation_date: 2009-10-13T11:25:04Z [Term] id: GO:0003240 name: conus arteriosus formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the conus arteriosus from unspecified parts. The conus arteriosus is a valved chamber with thick muscular walls stemming from the ventricle and connecting to the pulmonary trunk." [GOC:mtg_heart] is_a: GO:0003207 ! cardiac chamber formation relationship: part_of GO:0003239 ! conus arteriosus morphogenesis created_by: dph creation_date: 2009-10-13T11:25:47Z [Term] id: GO:0003241 name: growth involved in heart morphogenesis namespace: biological_process def: "Developmental growth that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis relationship: part_of GO:0060419 ! heart growth created_by: dph creation_date: 2009-10-13T11:28:46Z [Term] id: GO:0003242 name: cardiac chamber ballooning namespace: biological_process def: "The morphogenic growth in which the chambers of the heart expand in size, contributing to their shaping." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003206 ! cardiac chamber morphogenesis created_by: dph creation_date: 2009-10-13T11:30:30Z [Term] id: GO:0003243 name: circumferential growth involved in left ventricle morphogenesis namespace: biological_process def: "The morphogenetic growth in which the left ventricle grows expanding its external boundary." [GOC:mtg_heart, PMID:14709543] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003214 ! cardiac left ventricle morphogenesis created_by: dph creation_date: 2009-10-13T11:33:09Z [Term] id: GO:0003244 name: radial growth involved in right ventricle morphogenesis namespace: biological_process def: "The morphogenic growth in which the right ventricle grows along a radial axis." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis relationship: part_of GO:0003215 ! cardiac right ventricle morphogenesis created_by: dph creation_date: 2009-10-13T11:38:23Z [Term] id: GO:0003245 name: cardiac muscle tissue growth involved in heart morphogenesis namespace: biological_process def: "The developmental growth of cardiac muscle tissue that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0003241 ! growth involved in heart morphogenesis is_a: GO:0055017 ! cardiac muscle tissue growth relationship: part_of GO:0055008 ! cardiac muscle tissue morphogenesis created_by: dph creation_date: 2009-10-13T11:44:21Z [Term] id: GO:0003246 name: embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the embryonic period, that contributes to the shaping of the heart." [GOC:mtg_heart] synonym: "embryonic cardiac muscle physiological hypertrophy" EXACT [GOC:mtg_heart] is_a: GO:0061049 ! cell growth involved in cardiac muscle cell development relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis created_by: dph creation_date: 2009-10-13T11:46:23Z [Term] id: GO:0003247 name: post-embryonic cardiac muscle cell growth involved in heart morphogenesis namespace: biological_process def: "The growth of a cardiac muscle cell during the postembryonic period that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0003245 ! cardiac muscle tissue growth involved in heart morphogenesis created_by: dph creation_date: 2009-10-13T11:50:29Z [Term] id: GO:0003248 name: heart capillary growth namespace: biological_process def: "The increase in heart capillaries that accompanies physiological hypertrophy of cardiac muscle." [GOC:mtg_heart] is_a: GO:0048589 ! developmental growth relationship: part_of GO:0060419 ! heart growth relationship: part_of GO:0060976 ! coronary vasculature development created_by: dph creation_date: 2009-10-13T11:53:12Z [Term] id: GO:0003249 name: cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-13T01:59:19Z [Term] id: GO:0003250 name: regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:03:42Z [Term] id: GO:0003251 name: positive regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that increases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:0008284 ! positive regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: positively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:07:20Z [Term] id: GO:0003252 name: negative regulation of cell proliferation involved in heart valve morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of cell proliferation that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003250 ! regulation of cell proliferation involved in heart valve morphogenesis is_a: GO:0008285 ! negative regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis relationship: negatively_regulates GO:0003249 ! cell proliferation involved in heart valve morphogenesis created_by: dph creation_date: 2009-10-13T02:10:39Z [Term] id: GO:0003253 name: cardiac neural crest cell migration involved in outflow tract morphogenesis namespace: biological_process def: "The orderly movement of a neural crest cell from one site to another that will contribute to the morphogenesis of the outflow tract." [GOC:mtg_heart] is_a: GO:0001755 ! neural crest cell migration is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2009-10-13T02:14:16Z [Term] id: GO:0003254 name: regulation of membrane depolarization namespace: biological_process def: "Any process that modulates the rate, frequency or extent of membrane depolarization. Membrane depolarization is the process in which membrane potential changes in the depolarizing direction from the resting potential, usually from negative to positive." [GOC:dph, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051899 ! membrane depolarization relationship: regulates GO:0051899 ! membrane depolarization created_by: tanyaberardini creation_date: 2009-10-14T10:54:09Z [Term] id: GO:0003255 name: endocardial precursor cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of an endocardial precursor cell. A endocardial precursor cell is a cell that has been committed to a endocardial cell fate, but will undergo further cell divisions rather than terminally differentiate." [GOC:mtg_heart] is_a: GO:0010002 ! cardioblast differentiation created_by: dph creation_date: 2009-10-15T12:09:43Z [Term] id: GO:0003256 name: regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0060379 ! cardiac muscle cell myoblast differentiation created_by: dph creation_date: 2009-10-15T01:01:25Z [Term] id: GO:0003257 name: positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of a myocardial precursor cell." [GOC:mtg_heart] is_a: GO:0003256 ! regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter created_by: dph creation_date: 2009-10-15T01:07:25Z [Term] id: GO:0003258 name: regulation of transcription from RNA polymerase II promoter involved in endocardial precursor cell differentiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter that contributes to the differentiation of an endocardial precursor cell." [GOC:mtg_heart] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0003255 ! endocardial precursor cell differentiation created_by: dph creation_date: 2009-10-15T01:10:34Z [Term] id: GO:0003259 name: cardioblast anterior-lateral migration namespace: biological_process def: "The orderly movement of a cardioblast toward the head and laterally to form the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003260 ! cardioblast migration created_by: dph creation_date: 2009-10-15T01:17:28Z [Term] id: GO:0003260 name: cardioblast migration namespace: biological_process def: "The orderly movement of a cardiac progenitor cell to form the heart field. Cardiac progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into cells of the heart. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0060974 ! cell migration involved in heart formation relationship: part_of GO:0060914 ! heart formation created_by: dph creation_date: 2009-10-15T01:52:25Z [Term] id: GO:0003261 name: cardiac muscle progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of a myocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into myocardial cells of the heart." [GOC:mtg_heart] synonym: "myocardial progenitor cell midline convergence" EXACT [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation created_by: dph creation_date: 2009-10-15T01:57:55Z [Term] id: GO:0003262 name: endocardial progenitor cell migration to the midline involved in heart field formation namespace: biological_process def: "The orderly movement of an endocardial progenitor cell toward the midline to form the heart field. Cardiac muscle progenitor cells are non-terminally differentiated, mesoderm-derived cells that are committed to differentiate into endocardial cells of the heart." [GOC:mtg_heart] is_a: GO:0060975 ! cardioblast migration to the midline involved in heart field formation created_by: dph creation_date: 2009-10-15T02:00:41Z [Term] id: GO:0003263 name: cardioblast proliferation namespace: biological_process def: "The multiplication or reproduction of cardioblasts, resulting in the expansion of the population in the heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation is_a: GO:0060914 ! heart formation created_by: dph creation_date: 2009-10-15T02:13:05Z [Term] id: GO:0003264 name: regulation of cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003156 ! regulation of organ formation is_a: GO:0042127 ! regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003263 ! cardioblast proliferation relationship: regulates GO:0003263 ! cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:19:37Z [Term] id: GO:0003265 name: regulation of first heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the first heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003264 ! regulation of cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:25:26Z [Term] id: GO:0003266 name: regulation of second heart field cardioblast proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cardioblast proliferation in the second heart field. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003264 ! regulation of cardioblast proliferation created_by: dph creation_date: 2009-10-15T02:26:15Z [Term] id: GO:0003267 name: regulation of second heart field cardioblast proliferation by Wnt receptor signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation is_a: GO:0016055 ! Wnt receptor signaling pathway created_by: dph creation_date: 2009-10-15T02:36:08Z [Term] id: GO:0003268 name: regulation of second heart field cardioblast cell proliferation by fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation is_a: GO:0008543 ! fibroblast growth factor receptor signaling pathway created_by: dph creation_date: 2009-10-15T02:43:03Z [Term] id: GO:0003269 name: regulation of second heart field cardioblast proliferation by BMP signaling pathway namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation is_a: GO:0030509 ! BMP signaling pathway created_by: dph creation_date: 2009-10-15T02:45:28Z [Term] id: GO:0003270 name: regulation of second heart field cardioblast proliferation by Notch signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation is_a: GO:0007219 ! Notch signaling pathway created_by: dph creation_date: 2009-10-15T02:47:00Z [Term] id: GO:0003271 name: regulation of second heart field cardioblast proliferation by smoothened receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened resulting in the modulation of the frequency, rate or extent of cardioblast proliferation. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:mtg_heart] synonym: "regulation of second heart field cardioblast proliferation by hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of second heart field cardioblast proliferation by hh signaling pathway" EXACT [GOC:bf, GOC:ecd] is_a: GO:0003266 ! regulation of second heart field cardioblast proliferation is_a: GO:0007224 ! smoothened signaling pathway created_by: dph creation_date: 2009-10-15T02:48:32Z [Term] id: GO:0003272 name: endocardial cushion formation namespace: biological_process def: "The developmental process pertaining to the initial formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart, PMID:15797462] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T08:53:19Z [Term] id: GO:0003273 name: cell migration involved in endocardial cushion formation namespace: biological_process def: "The orderly movement of a cell from one site to another that will contribute to the formation of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003272 ! endocardial cushion formation created_by: dph creation_date: 2009-10-20T09:08:44Z [Term] id: GO:0003274 name: endocardial cushion fusion namespace: biological_process def: "The cell-cell adhesion process of mesenchymal cardiac cushion cells that contributes to the process of cushion shaping." [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:26:32Z [Term] id: GO:0003275 name: apoptosis involved in outflow tract morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of the outflow tract. The outflow tract is the portion of the heart through which blood flows into the arteries." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003151 ! outflow tract morphogenesis created_by: dph creation_date: 2009-10-20T09:30:01Z [Term] id: GO:0003276 name: apoptosis involved in heart valve morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of a heart valve." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003179 ! heart valve morphogenesis created_by: dph creation_date: 2009-10-20T09:34:29Z [Term] id: GO:0003277 name: apoptosis involved in endocardial cushion morphogenesis namespace: biological_process def: "The apoptosis process that contributes to the shaping of an endocardial cushion. The endocardial cushion is a specialized region of mesenchymal cells that will give rise to the heart septa and valves." [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003203 ! endocardial cushion morphogenesis created_by: dph creation_date: 2009-10-20T09:37:03Z [Term] id: GO:0003278 name: apoptosis involved in heart morphogenesis namespace: biological_process def: "The process of apoptosis that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0060561 ! apoptosis involved in morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-20T09:40:22Z [Term] id: GO:0003279 name: cardiac septum development namespace: biological_process def: "The progression of a cardiac septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] synonym: "heart septum development" EXACT [GOC:mtg_heart] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0003205 ! cardiac chamber development created_by: dph creation_date: 2009-10-20T09:45:13Z [Term] id: GO:0003281 name: ventricular septum development namespace: biological_process def: "The progression of the ventricular septum over time from its formation to the mature structure." [GOC:mtg_heart] synonym: "interventricular septum development" EXACT [GOC:mtg_heart] synonym: "septum inferius development" NARROW [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003231 ! cardiac ventricle development created_by: dph creation_date: 2009-10-20T10:04:51Z [Term] id: GO:0003282 name: ventricular septum intermedium development namespace: biological_process def: "The progression of the ventricular septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003281 ! ventricular septum development created_by: dph creation_date: 2009-10-20T10:09:53Z [Term] id: GO:0003283 name: atrial septum development namespace: biological_process def: "The progression of the atrial septum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003279 ! cardiac septum development relationship: part_of GO:0003230 ! cardiac atrium development created_by: dph creation_date: 2009-10-20T10:10:38Z [Term] id: GO:0003284 name: septum primum development namespace: biological_process def: "The progression of the septum primum over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:12:26Z [Term] id: GO:0003285 name: septum secundum development namespace: biological_process def: "The progression of the septum secundum over time, from its initial formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:21:13Z [Term] id: GO:0003286 name: atrial septum intermedium development namespace: biological_process def: "The progression of the atrial septum intermedium over time, from its formation to the mature structure." [GOC:mtg_heart] is_a: GO:0003283 ! atrial septum development created_by: dph creation_date: 2009-10-20T10:23:52Z [Term] id: GO:0003288 name: ventricular septum intermedium morphogenesis namespace: biological_process def: "The developmental process by which a ventricular septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060412 ! ventricular septum morphogenesis created_by: dph creation_date: 2009-10-20T10:58:48Z [Term] id: GO:0003289 name: atrial septum primum morphogenesis namespace: biological_process def: "The process by which anatomical structure of an atrial septum primum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003284 ! septum primum development created_by: dph creation_date: 2009-10-20T10:32:32Z [Term] id: GO:0003290 name: atrial septum secundum morphogenesis namespace: biological_process def: "The process by which anatomical structure of an atrial septum secundum is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003285 ! septum secundum development created_by: dph creation_date: 2009-10-20T10:33:57Z [Term] id: GO:0003291 name: atrial septum intermedium morphogenesis namespace: biological_process def: "The process by which anatomical structure of an atrial septum intermedium is generated and organized." [GOC:mtg_heart] is_a: GO:0060413 ! atrial septum morphogenesis relationship: part_of GO:0003286 ! atrial septum intermedium development created_by: dph creation_date: 2009-10-20T10:35:04Z [Term] id: GO:0003292 name: cardiac septum cell differentiation namespace: biological_process def: "The process by which an endocardial cushion cell becomes a cell of a cardiac septum." [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation relationship: part_of GO:0003279 ! cardiac septum development created_by: dph creation_date: 2009-10-20T11:03:46Z [Term] id: GO:0003293 name: heart valve cell differentiation namespace: biological_process def: "The process by which an endocardial cushion cell give rise to a cell that is part of a heart valve." [GOC:mtg_heart] is_a: GO:0035051 ! cardiac cell differentiation relationship: part_of GO:0003170 ! heart valve development created_by: dph creation_date: 2009-10-20T11:06:46Z [Term] id: GO:0003294 name: atrial ventricular junction remodeling namespace: biological_process def: "The reorganization or renovation of heart tissue that contributes to the process by which the connection between an atrium and a ventricle matures." [GOC:mtg_heart] synonym: "atrio-ventricular junction remodeling " RELATED [GOC:mtg_heart] synonym: "atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0048771 ! tissue remodeling relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-22T08:35:36Z [Term] id: GO:0003295 name: cell proliferation involved in atrial ventricular junction remodeling namespace: biological_process def: "The multiplication or reproduction of cells that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "cell proliferation involved in atrio-ventricular junction remodeling " EXACT [GOC:mtg_heart] synonym: "cell proliferation involved in atrioventricular junction remodeling" EXACT [GOC:mtg_heart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003294 ! atrial ventricular junction remodeling created_by: dph creation_date: 2009-10-22T08:38:30Z [Term] id: GO:0003296 name: apoptosis involved in atrial ventricular junction remodeling namespace: biological_process def: "The process of apoptosis that contributes to the reorganization of tissue resulting in the maturation of the atrial ventricular junction." [GOC:mtg_heart] synonym: "apoptosis involved in atrio-ventricular junction remodeling" EXACT [GOC:mtg_heart] synonym: "apoptosis involved in atrioventricular junction remodeling " EXACT [GOC:mtg_heart] is_a: GO:0003278 ! apoptosis involved in heart morphogenesis relationship: part_of GO:0003294 ! atrial ventricular junction remodeling created_by: dph creation_date: 2009-10-22T08:43:11Z [Term] id: GO:0003297 name: heart wedging namespace: biological_process def: "The morphogenetic process by which the aorta inserts between the atrioventricular valves that contributes to the shaping of the heart." [GOC:mtg_heart] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0003007 ! heart morphogenesis created_by: dph creation_date: 2009-10-22T08:52:58Z [Term] id: GO:0003298 name: physiological muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells. Physiological hypertrophy is a normal process during development." [GOC:mtg_heart] is_a: GO:0014896 ! muscle hypertrophy created_by: dph creation_date: 2009-10-22T09:24:51Z [Term] id: GO:0003299 name: muscle hypertrophy in response to stress namespace: biological_process def: "The enlargement or overgrowth of all or part of a muscle organ or tissue due to an increase in the size of its muscle cells as a result of a disturbance in organismal or cellular homeostasis." [GOC:mtg_heart] is_a: GO:0006950 ! response to stress is_a: GO:0014896 ! muscle hypertrophy is_a: GO:0043500 ! muscle adaptation created_by: dph creation_date: 2009-10-22T09:26:10Z [Term] id: GO:0003300 name: cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division." [GOC:mtg_heart] is_a: GO:0014897 ! striated muscle hypertrophy created_by: dph creation_date: 2009-10-22T10:33:56Z [Term] id: GO:0003301 name: physiological cardiac muscle hypertrophy namespace: biological_process def: "The enlargement or overgrowth of all or part of the heart muscle due to an increase in size of cardiac muscle cells without cell division. This process contributes to the developmental growth of the heart." [GOC:mtg_heart] is_a: GO:0003300 ! cardiac muscle hypertrophy relationship: part_of GO:0055017 ! cardiac muscle tissue growth created_by: dph creation_date: 2009-10-22T10:38:10Z [Term] id: GO:0003302 name: transforming growth factor beta receptor signaling pathway involved in heart jogging namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart] synonym: "nodal signaling involved in heart jogging" NARROW [GOC:mtg_heart] is_a: GO:0007179 ! transforming growth factor beta receptor signaling pathway relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T10:51:58Z [Term] id: GO:0003303 name: BMP signaling pathway involved in heart jogging namespace: biological_process def: "The series of molecular signals generated as a consequence of a bone morphogenic protein receptor binding to one of its physiological ligands that contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:00:58Z [Term] id: GO:0003304 name: myocardial epithelial involution involved in heart jogging namespace: biological_process def: "The morphogenetic process by which the myocardium bends along a linear axis and contributes to the process of heart jogging." [GOC:mtg_heart] is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:03:33Z [Term] id: GO:0003305 name: cell migration involved in heart jogging namespace: biological_process def: "The orderly movement of a cell of the myocardium from one site to another that will contribute to heart jogging." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development relationship: part_of GO:0003146 ! heart jogging created_by: dph creation_date: 2009-10-22T11:05:46Z [Term] id: GO:0003306 name: Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "The series of molecular signals initiated by binding of Wnt protein to a receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0016055 ! Wnt receptor signaling pathway relationship: part_of GO:0007507 ! heart development created_by: dph creation_date: 2009-10-22T12:26:07Z [Term] id: GO:0003307 name: regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development relationship: regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:32:10Z [Term] id: GO:0003308 name: negative regulation of Wnt receptor signaling pathway involved in heart development namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, resulting a change in cell state that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0003307 ! regulation of Wnt receptor signaling pathway involved in heart development is_a: GO:0030178 ! negative regulation of Wnt receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development relationship: negatively_regulates GO:0003306 ! Wnt receptor signaling pathway involved in heart development created_by: dph creation_date: 2009-10-22T12:36:11Z [Term] id: GO:0003309 name: pancreatic B cell differentiation namespace: biological_process def: "The process whereby relatively unspecialized cells acquire specialized structural and/or functional features of a pancreatic beta cell. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph, PMID:11076772] synonym: "pancreatic beta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:27:23Z [Term] id: GO:0003310 name: pancreatic A cell differentiation namespace: biological_process def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features of a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph, PMID:11076772] synonym: "pancreatic alpha cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:28:05Z [Term] id: GO:0003311 name: pancreatic D cell differentiation namespace: biological_process def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features that characterize a pancreatic delta cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph, PMID:11076772] synonym: "pancreatic delta cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:30:27Z [Term] id: GO:0003312 name: pancreatic PP cell differentiation namespace: biological_process def: "The process whereby relatively unspecialized cells acquire specialized structural and functional features of a pancreatic polypeptide-producing cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph, PMID:11076772] synonym: "pancreatic polypeptide-producing cell differentiation" EXACT [GOC:dph] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0031018 ! endocrine pancreas development created_by: dph creation_date: 2009-10-26T09:32:32Z [Term] id: GO:0003313 name: heart rudiment development namespace: biological_process def: "The progression of the heart rudiment over time, from its initial formation to the mature structure. The heart rudiment is a cone-like structure that is formed when myocardial progenitor cells of the heart field fuse at the midline. The heart rudiment is the first structure of the heart tube." [GOC:mtg_heart] synonym: "heart cone development" EXACT [GOC:mtg_heart] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0035050 ! embryonic heart tube development created_by: dph creation_date: 2009-10-27T08:32:40Z [Term] id: GO:0003314 name: heart rudiment morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the heart rudiment are generated and organized." [GOC:mtg_heart] synonym: "heart cone morphogenesis" EXACT [GOC:mtg_heart] is_a: GO:0002009 ! morphogenesis of an epithelium is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0003313 ! heart rudiment development created_by: dph creation_date: 2009-10-27T08:38:04Z [Term] id: GO:0003315 name: heart rudiment formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the heart rudiment." [GOC:mtg_heart] synonym: "heart cone formation" EXACT [GOC:mtg_heart] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003314 ! heart rudiment morphogenesis created_by: dph creation_date: 2009-10-27T08:43:37Z [Term] id: GO:0003316 name: establishment of myocardial progenitor cell apical/basal polarity namespace: biological_process def: "The specification and formation of the apicobasal polarity of an myocardial progenitor cell that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "myocardial progenitor epithelial polarization" EXACT [GOC:mtg_heart] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:01:26Z [Term] id: GO:0003317 name: cardioblast cell midline fusion namespace: biological_process def: "The attachment of cardiac progenitor cells to one another that contributes to the formation of the heart rudiment." [GOC:mtg_heart] synonym: "cardiac progenitor cell midline fusion" EXACT [GOC:mtg_heart] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:08:57Z [Term] id: GO:0003318 name: cell migration to the midline involved in heart development namespace: biological_process def: "The orderly movement of a cell toward the midline that contributes to the progression of the heart over time." [GOC:mtg_heart] is_a: GO:0060973 ! cell migration involved in heart development created_by: dph creation_date: 2009-10-27T09:15:43Z [Term] id: GO:0003319 name: cardioblast migration to the midline involved in heart rudiment formation namespace: biological_process def: "The orderly movement of a cardioblast toward the midline that contributes to the initial appearance of the heart rudiment." [GOC:mtg_heart] is_a: GO:0003318 ! cell migration to the midline involved in heart development relationship: part_of GO:0003315 ! heart rudiment formation created_by: dph creation_date: 2009-10-27T09:21:36Z [Term] id: GO:0003320 name: heart rudiment involution namespace: biological_process def: "The inward folding of myocardial tissue derived from the right half of the heart rudiment that will form the future ventral part of the heart tube." [GOC:mtg_heart] is_a: GO:0003152 ! morphogenesis of an epithelial fold involved in embryonic heart tube formation created_by: dph creation_date: 2009-10-27T09:29:24Z [Term] id: GO:0003321 name: positive regulation of blood pressure by epinephrine-norepinephrine namespace: biological_process def: "Any process by which the force of blood traveling through the circulatory system is increased by the chemicals epinephrine and norepinephrine." [GOC:dph] is_a: GO:0001993 ! regulation of systemic arterial blood pressure by norepinephrine-epinephrine is_a: GO:0045777 ! positive regulation of blood pressure created_by: dph creation_date: 2009-10-29T01:52:50Z [Term] id: GO:0003322 name: pancreatic A cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic A cell over time, from its formation to the mature structure. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] synonym: "pancreatic alpha cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003310 ! pancreatic A cell differentiation created_by: dph creation_date: 2009-11-02T08:13:55Z [Term] id: GO:0003323 name: pancreatic B cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic B cell over time, from its formation to the mature structure. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph] synonym: "pancreatic beta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003309 ! pancreatic B cell differentiation created_by: dph creation_date: 2009-11-02T08:20:11Z [Term] id: GO:0003324 name: pancreatic D cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic delta cell over time, from its formation to the mature structure. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] synonym: "pancreatic delta cell development" EXACT [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003311 ! pancreatic D cell differentiation created_by: dph creation_date: 2009-11-02T08:23:26Z [Term] id: GO:0003325 name: pancreatic PP cell development namespace: biological_process def: "The process whose specific outcome is the progression of a pancreatic PP cell over time, from its formation to the mature structure. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0048468 ! cell development relationship: part_of GO:0003312 ! pancreatic PP cell differentiation created_by: dph creation_date: 2009-11-02T08:25:03Z [Term] id: GO:0003326 name: pancreatic A cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic A cell and its capacity to differentiate into a pancreatic A cell. A pancreatic A cell is a cell in the pancreas that secretes glucagon." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003310 ! pancreatic A cell differentiation created_by: dph creation_date: 2009-11-02T08:29:00Z [Term] id: GO:0003327 name: pancreatic B cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic B cell fate and its capacity to differentiate into a pancreatic B cell. Beta cells are cells of the pancreas that secrete insulin." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003309 ! pancreatic B cell differentiation created_by: dph creation_date: 2009-11-02T08:31:24Z [Term] id: GO:0003328 name: pancreatic D cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic D cell fate and its capacity to differentiate into a pancreatic D cell. A delta cell is a cell of the pancreas that produces somatostatin." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003311 ! pancreatic D cell differentiation created_by: dph creation_date: 2009-11-02T08:33:36Z [Term] id: GO:0003329 name: pancreatic PP cell fate commitment namespace: biological_process def: "The commitment of a cell to a pancreatic PP cell fate and its capacity to differentiate into a pancreatic PP cell. A pancreatic polypeptide-producing cell is a cell in the pancreas that produces pancreatic polypeptide." [GOC:dph] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0003312 ! pancreatic PP cell differentiation created_by: dph creation_date: 2009-11-02T08:35:13Z [Term] id: GO:0003330 name: regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0051046 ! regulation of secretion is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0070278 ! extracellular matrix constituent secretion relationship: regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:07:40Z [Term] id: GO:0003331 name: positive regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that increases the rate, frequency, or extent of the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051047 ! positive regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0070278 ! extracellular matrix constituent secretion relationship: positively_regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:11:22Z [Term] id: GO:0003332 name: negative regulation of extracellular matrix constituent secretion namespace: biological_process def: "Any process that decreases the rate, frequency, or extent the controlled release of molecules that form the extracellular matrix, including carbohydrates and glycoproteins by a cell or a group of cells." [GOC:dph, GOC:tb] is_a: GO:0003330 ! regulation of extracellular matrix constituent secretion is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051048 ! negative regulation of secretion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion relationship: negatively_regulates GO:0070278 ! extracellular matrix constituent secretion created_by: dph creation_date: 2009-11-02T02:13:49Z [Term] id: GO:0003333 name: amino acid transmembrane transport namespace: biological_process def: "The directed movement of amino acids, organic acids containing one or more amino substituents across a membrane." [GOC:dph, GOC:tb] is_a: GO:0006865 ! amino acid transport is_a: GO:0055085 ! transmembrane transport created_by: dph creation_date: 2009-11-02T02:36:11Z [Term] id: GO:0003334 name: keratinocyte development namespace: biological_process def: "The process whose specific outcome is the progression of a keratinocyte over time, from its formation to the mature structure." [GOC:dph] is_a: GO:0002064 ! epithelial cell development is_a: GO:0030216 ! keratinocyte differentiation created_by: dph creation_date: 2009-11-24T08:55:57Z [Term] id: GO:0003335 name: corneocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the corneocyte over time, from its formation to the mature structure. A corneocyte is the last stage of development of a keratinocyte where the keratinocyte flattens, loses its nucleus and eventually delaminates from the epidermis." [GOC:dph] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0003334 ! keratinocyte development created_by: dph creation_date: 2009-11-24T09:01:02Z [Term] id: GO:0003336 name: corneocyte desquamation namespace: biological_process def: "The negative regulation of cell adhesion process by which a corneocyte is shed from the surface of the epidermis." [GOC:dph] synonym: "epidermal desquamation" EXACT [GOC:dph] is_a: GO:0060232 ! delamination relationship: part_of GO:0003335 ! corneocyte development created_by: dph creation_date: 2009-11-24T09:11:53Z [Term] id: GO:0003337 name: mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "A transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] synonym: "metanephric mesenchyme to epithelial transition" RELATED [GOC:dph] is_a: GO:0060231 ! mesenchymal to epithelial transition relationship: part_of GO:0072283 ! metanephric renal vesicle morphogenesis created_by: dph creation_date: 2009-11-24T09:29:49Z [Term] id: GO:0003338 name: metanephros morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the metanephros are generated and organized. Morphogenesis pertains to the creation of form." [GOC:dph] is_a: GO:0060993 ! kidney morphogenesis relationship: part_of GO:0001656 ! metanephros development created_by: dph creation_date: 2009-11-24T09:32:09Z [Term] id: GO:0003339 name: regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that modulates the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0010769 ! regulation of cell morphogenesis involved in differentiation is_a: GO:0030856 ! regulation of epithelial cell differentiation is_a: GO:0072215 ! regulation of metanephros development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis created_by: dph creation_date: 2009-11-24T09:43:04Z [Term] id: GO:0003340 name: negative regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis namespace: biological_process def: "Any process that decreases the rate, frequency or extent of the transition where a mesenchymal cell establishes apical/basolateral polarity,forms intercellular adhesive junctions, synthesizes basement membrane components and becomes an epithelial cell that will contribute to the shaping of the metanephros." [GOC:dph] is_a: GO:0003339 ! regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis is_a: GO:0010771 ! negative regulation of cell morphogenesis involved in differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis relationship: negatively_regulates GO:0003337 ! mesenchymal to epithelial transition involved in metanephros morphogenesis created_by: dph creation_date: 2009-11-24T09:46:12Z [Term] id: GO:0003341 name: cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium." [GOC:dph, GOC:jl] synonym: "cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0006928 ! cellular component movement is_a: GO:0007018 ! microtubule-based movement created_by: dph creation_date: 2009-11-24T09:56:26Z [Term] id: GO:0003342 name: proepicardium development namespace: biological_process def: "The progression of the proepicardium from its formation to the mature structure. The proepicardium is an outpouching of the septum transversum." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development relationship: part_of GO:0003343 ! septum transversum development created_by: dph creation_date: 2009-12-01T10:30:17Z [Term] id: GO:0003343 name: septum transversum development namespace: biological_process def: "The progression of the septum transversum from its initial formation to the mature structure. The septum transversum is a portion of the trunk mesenchyme." [GOC:dph, PMID:18722343] is_a: GO:0060485 ! mesenchyme development created_by: dph creation_date: 2009-12-01T10:40:17Z [Term] id: GO:0003344 name: pericardium morphogenesis namespace: biological_process def: "The process by which the anatomical structure of the pericardium is generated and organized." [GOC:dph, PMID:18722343] is_a: GO:0002011 ! morphogenesis of an epithelial sheet is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0060039 ! pericardium development created_by: dph creation_date: 2009-12-01T10:46:34Z [Term] id: GO:0003345 name: proepicardium cell migration involved in pericardium morphogenesis namespace: biological_process def: "The coordinated movement of a mesenchymal proepicardial cell to the surface of the developing heart." [GOC:dph, PMID:18722343] is_a: GO:0016477 ! cell migration relationship: part_of GO:0003344 ! pericardium morphogenesis created_by: dph creation_date: 2009-12-01T10:49:32Z [Term] id: GO:0003346 name: epicardium-derived cell migration to the myocardium namespace: biological_process def: "The orderly movement of a cell that have undergone an epithelial to mesenchymal transition from the epicardium into the myocardium." [GOC:dph, PMID:18722343] is_a: GO:0060973 ! cell migration involved in heart development created_by: dph creation_date: 2009-12-01T11:00:42Z [Term] id: GO:0003347 name: epicardial cell to mesenchymal cell transition namespace: biological_process def: "A transition where an epicardial cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell. The epicardium is a part of the pericardium." [GOC:dph, PMID:18722343] is_a: GO:0001837 ! epithelial to mesenchymal transition created_by: dph creation_date: 2009-12-01T11:05:39Z [Term] id: GO:0003348 name: cardiac endothelial cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0035051 ! cardiac cell differentiation created_by: dph creation_date: 2009-12-01T11:12:05Z [Term] id: GO:0003349 name: epicardium-derived cardiac endothelial cell differentiation namespace: biological_process def: "The process whereby an epicardial cell acquires the specialized structural and/or functional features of a cardiac endothelial cell." [GOC:dph, PMID:18722343] is_a: GO:0003348 ! cardiac endothelial cell differentiation created_by: dph creation_date: 2009-12-01T11:17:49Z [Term] id: GO:0003350 name: pulmonary myocardium development namespace: biological_process def: "The progression of the pulmonary myocardium over time, from its initial formation to the mature structure. The pulmonary myocardium is the myocardial tissue present in the pulmonary vein." [GOC:dph, PMID:17638577] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060841 ! venous blood vessel development created_by: dph creation_date: 2009-12-01T12:50:06Z [Term] id: GO:0003351 name: epithelial cilium movement namespace: biological_process def: "The directed, self-propelled movement of a cilium of an epithelial cell. This movement is usually coordinated between many epithelial cells, and serves to move fluid." [GOC:dph] synonym: "epithelial cilium beating" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:08:25Z [Term] id: GO:0003352 name: regulation of cilium movement namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0051270 ! regulation of cellular component movement is_a: GO:0060632 ! regulation of microtubule-based movement intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003341 ! cilium movement relationship: regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:12:00Z [Term] id: GO:0003353 name: positive regulation of cilium movement namespace: biological_process def: "Any process that increases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051272 ! positive regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0003341 ! cilium movement relationship: positively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:16:10Z [Term] id: GO:0003354 name: negative regulation of cilium movement namespace: biological_process def: "Any process that decreases the rate, frequency, or extent of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement is_a: GO:0051271 ! negative regulation of cellular component movement intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0003341 ! cilium movement relationship: negatively_regulates GO:0003341 ! cilium movement created_by: dph creation_date: 2009-12-03T10:17:47Z [Term] id: GO:0003355 name: cilium movement involved in otolith formation namespace: biological_process def: "The directed, self-propelled movement of a cilium of an inner ear epithelial cell, resulting the aggregation of otolith seed particles." [GOC:dph] is_a: GO:0003351 ! epithelial cilium movement relationship: part_of GO:0032475 ! otolith formation created_by: dph creation_date: 2009-12-03T10:21:08Z [Term] id: GO:0003356 name: regulation of cilium beat frequency namespace: biological_process def: "Any process that modulates the frequency of cilium movement, the directed, self-propelled movement of a cilium." [GOC:dph] is_a: GO:0003352 ! regulation of cilium movement created_by: dph creation_date: 2009-12-03T10:27:12Z [Term] id: GO:0003357 name: noradrenergic neuron differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of an noradrenergic neuron, a neuron that secretes noradrenaline." [GOC:dph] synonym: "norepinephrine secreting neuron differentiation" EXACT [GOC:dph] is_a: GO:0030182 ! neuron differentiation created_by: dph creation_date: 2009-12-03T10:34:30Z [Term] id: GO:0003358 name: noradrenergic neuron development namespace: biological_process def: "The process whose specific outcome is the progression of a noradrenergic neuron over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell." [GOC:dph] synonym: "norepinephrine secreting neuron development" EXACT [GOC:dph] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003357 ! noradrenergic neuron differentiation created_by: dph creation_date: 2009-12-03T10:38:37Z [Term] id: GO:0003359 name: noradrenergic neuron fate commitment namespace: biological_process def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron." [GOC:dph] synonym: "norepinephrine secreting neuron fate commitment" EXACT [GOC:dph] is_a: GO:0048663 ! neuron fate commitment relationship: part_of GO:0003357 ! noradrenergic neuron differentiation created_by: dph creation_date: 2009-12-03T10:41:08Z [Term] id: GO:0003360 name: brainstem development namespace: biological_process def: "The progression of the brainstem from its formation to the mature structure. The brainstem is the part of the brain that connects the brain with the spinal cord." [GOC:dph] is_a: GO:0048856 ! anatomical structure development created_by: dph creation_date: 2009-12-03T10:47:20Z [Term] id: GO:0003361 name: noradrenergic neuron differentiation involved in brainstem development namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of an noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003357 ! noradrenergic neuron differentiation relationship: part_of GO:0003360 ! brainstem development created_by: dph creation_date: 2009-12-03T10:53:30Z [Term] id: GO:0003362 name: noradrenergic neuron fate commitment involved in brainstem development namespace: biological_process def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a noradrenergic neuron that is part of the brainstem." [GOC:dph] is_a: GO:0003359 ! noradrenergic neuron fate commitment relationship: part_of GO:0003361 ! noradrenergic neuron differentiation involved in brainstem development created_by: dph creation_date: 2009-12-03T10:56:16Z [Term] id: GO:0003363 name: lamellipodium assembly involved in ameboidal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self propelled movement of a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030032 ! lamellipodium assembly relationship: part_of GO:0001667 ! ameboidal cell migration created_by: dph creation_date: 2009-12-08T04:38:04Z [Term] id: GO:0003364 name: lamellipodium assembly involved in mesendodermal cell migration namespace: biological_process def: "Formation of a lamellipodium, a thin sheetlike extension of the surface of a migrating cell that contributes to the directed self-propelled movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003363 ! lamellipodium assembly involved in ameboidal cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T04:46:39Z [Term] id: GO:0003365 name: establishment of cell polarity involved in ameboidal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0001667 ! ameboidal cell migration created_by: dph creation_date: 2009-12-08T04:50:41Z [Term] id: GO:0003366 name: cell-matrix adhesion involved in ameboidal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of an ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007160 ! cell-matrix adhesion relationship: part_of GO:0001667 ! ameboidal cell migration created_by: dph creation_date: 2009-12-08T04:54:33Z [Term] id: GO:0003367 name: cell-cell adhesion involved in ameboidal cell migration namespace: biological_process def: "The attachment of one ameboid cell to another that contributes to the establishment of cell polarity that is part of the directed movement of one of the cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016337 ! cell-cell adhesion relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration created_by: dph creation_date: 2009-12-08T05:15:49Z [Term] id: GO:0003368 name: cell-matrix adhesion involved in mesendodermal cell migration namespace: biological_process def: "The binding of a cell to the extracellular matrix that contributes to the directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003366 ! cell-matrix adhesion involved in ameboidal cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T05:26:12Z [Term] id: GO:0003369 name: establishment of cell polarity involved in mesendodermal cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of a mesendodermal cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration relationship: part_of GO:0090134 ! cell migration involved in mesendoderm migration created_by: dph creation_date: 2009-12-08T05:31:51Z [Term] id: GO:0003370 name: cell-cell adhesion involved in mesendodermal cell migration namespace: biological_process def: "The attachment of mesendodermal cells to each other that contributes to the establishment of cell polarity that is part of the directed movement of the cells of the mesendoderm." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003367 ! cell-cell adhesion involved in ameboidal cell migration relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration created_by: dph creation_date: 2009-12-08T05:33:51Z [Term] id: GO:0003371 name: establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030952 ! establishment or maintenance of cytoskeleton polarity relationship: part_of GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration created_by: dph creation_date: 2009-12-08T05:42:46Z [Term] id: GO:0003372 name: establishment or maintenance of cytoskeleton polarity involved in mesendodermal cell migration namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003380 ! establishment or maintenance of cytoskeleton polarity involved in gastrulation relationship: part_of GO:0003369 ! establishment of cell polarity involved in mesendodermal cell migration created_by: dph creation_date: 2009-12-08T05:46:23Z [Term] id: GO:0003373 name: dynamin polymerization involved in membrane fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051258 ! protein polymerization relationship: part_of GO:0090148 ! membrane fission created_by: dph creation_date: 2009-12-09T04:55:16Z [Term] id: GO:0003374 name: dynamin polymerization involved in mitochondrial fission namespace: biological_process def: "The process of creating dynamin polymers, compounds composed of a large number of dynamin monomers around a lipid tube of a dividing mitochondrion. Dynamin polymers form around lipid tubes and contribute to membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003373 ! dynamin polymerization involved in membrane fission created_by: dph creation_date: 2009-12-09T05:39:52Z [Term] id: GO:0003375 name: regulation of dynamin polymerization involved in membrane fission namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of membrane fission." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0032271 ! regulation of protein polymerization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003373 ! dynamin polymerization involved in membrane fission relationship: regulates GO:0003373 ! dynamin polymerization involved in membrane fission created_by: dph creation_date: 2009-12-09T05:50:15Z [Term] id: GO:0003376 name: sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0023033 ! signaling pathway created_by: dph creation_date: 2009-12-09T06:30:12Z [Term] id: GO:0003377 name: regulation of apoptosis by sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of apoptosis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003376 ! sphingolipid signaling pathway is_a: GO:0042981 ! regulation of apoptosis created_by: dph creation_date: 2009-12-09T06:32:22Z [Term] id: GO:0003378 name: regulation of inflammatory response by sphingolipid signaling pathway namespace: biological_process def: "A series of molecular signals mediated by a sphingolipid that modulates the rate, frequency, or extent of the inflammatory response." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003376 ! sphingolipid signaling pathway is_a: GO:0050727 ! regulation of inflammatory response created_by: dph creation_date: 2009-12-09T06:38:06Z [Term] id: GO:0003379 name: establishment of cell polarity involved in gastrulation cell migration namespace: biological_process def: "The specification and formation of anisotropic intracellular organization that contributes to the self-propelled directed movement of an ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003365 ! establishment of cell polarity involved in ameboidal cell migration relationship: part_of GO:0042074 ! cell migration involved in gastrulation created_by: dph creation_date: 2009-12-09T06:54:44Z [Term] id: GO:0003380 name: establishment or maintenance of cytoskeleton polarity involved in gastrulation namespace: biological_process def: "Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures that contribute to the cell polarity of a migrating ameboid cell taking part in gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003371 ! establishment or maintenance of cytoskeleton polarity involved in ameboidal cell migration relationship: part_of GO:0003379 ! establishment of cell polarity involved in gastrulation cell migration created_by: dph creation_date: 2009-12-09T07:10:57Z [Term] id: GO:0003381 name: epithelial cell morphogenesis involved in gastrulation namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from it initial formation to its mature state, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003382 ! epithelial cell morphogenesis is_a: GO:0007369 ! gastrulation created_by: dph creation_date: 2009-12-09T07:18:53Z [Term] id: GO:0003382 name: epithelial cell morphogenesis namespace: biological_process def: "The change in form that occurs when an epithelial cell progresses from its initial formation to its mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0002064 ! epithelial cell development created_by: dph creation_date: 2009-12-09T07:21:06Z [Term] id: GO:0003383 name: apical constriction namespace: biological_process def: "The actin-mediated process by which the apical end of a polarized columnar epithelial cell contracts." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0003382 ! epithelial cell morphogenesis created_by: dph creation_date: 2009-12-09T07:30:34Z [Term] id: GO:0003384 name: apical constriction involved in gastrulation namespace: biological_process def: "The actin-mediated process by which the apical end of a polarized columnar epithelial cell contracts, contributing to the process of gastrulation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003383 ! apical constriction relationship: part_of GO:0003381 ! epithelial cell morphogenesis involved in gastrulation created_by: dph creation_date: 2009-12-09T07:35:38Z [Term] id: GO:0003385 name: cell-cell signaling involved in amphid sensory organ development namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another and contributes to the progression of an amphid sensory organ over time, from its formation to the mature state." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0003386 ! amphid sensory organ development created_by: dph creation_date: 2009-12-09T08:55:37Z [Term] id: GO:0003386 name: amphid sensory organ development namespace: biological_process def: "The progression of the amphid sensory organ over time, from it's formation to the mature structure. Amphid sensory organs are the sensory organs of nematodes." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007423 ! sensory organ development created_by: dph creation_date: 2009-12-09T09:09:20Z [Term] id: GO:0003387 name: neuron differentiation involved in amphid sensory organ development namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires specialized features of a neuron that contributes to the progression of the amphid sensory gland." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030182 ! neuron differentiation relationship: part_of GO:0003386 ! amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:15:00Z [Term] id: GO:0003388 name: neuron development involved in amphid sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of a neuron over time, that contributes to the development of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048666 ! neuron development relationship: part_of GO:0003387 ! neuron differentiation involved in amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:18:06Z [Term] id: GO:0003389 name: retrograde extension namespace: biological_process def: "The progression of a neuronal projection over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0031175 ! neuron projection development created_by: dph creation_date: 2009-12-09T09:22:03Z [Term] id: GO:0003390 name: dendrite development by retrograde extension namespace: biological_process def: "The progression of a dendrite over time by the attachment of a part of the neuron to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "dendrite retrograde extension" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003389 ! retrograde extension is_a: GO:0016358 ! dendrite development created_by: dph creation_date: 2009-12-09T09:25:24Z [Term] id: GO:0003391 name: amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The progression of an amphid sensory organ's neuronal dendrite over time by the attachment of a part of the cell to an anchor and the subsequent migration of the cell body away from the anchor point." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003390 ! dendrite development by retrograde extension relationship: part_of GO:0003388 ! neuron development involved in amphid sensory organ development created_by: dph creation_date: 2009-12-09T09:28:27Z [Term] id: GO:0003392 name: cell adhesion involved in retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007155 ! cell adhesion relationship: part_of GO:0003389 ! retrograde extension created_by: dph creation_date: 2009-12-09T09:32:06Z [Term] id: GO:0003393 name: neuron migration involved in retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001764 ! neuron migration relationship: part_of GO:0003389 ! retrograde extension created_by: dph creation_date: 2009-12-09T09:36:03Z [Term] id: GO:0003394 name: cell adhesion involved in dendrite retrograde extension namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003392 ! cell adhesion involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension created_by: dph creation_date: 2009-12-09T09:42:09Z [Term] id: GO:0003395 name: neuron migration involved in dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003393 ! neuron migration involved in retrograde extension relationship: part_of GO:0003390 ! dendrite development by retrograde extension created_by: dph creation_date: 2009-12-09T09:44:24Z [Term] id: GO:0003396 name: cell adhesion involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite in a neuron of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003394 ! cell adhesion involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension created_by: dph creation_date: 2009-12-09T09:50:18Z [Term] id: GO:0003397 name: neuron migration involved in amphid sensory organ dendrite retrograde extension namespace: biological_process def: "The directed, self-propelled movement of a neuron that contributes to the process of retrograde extension of a dendrite of a neuron in the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003395 ! neuron migration involved in dendrite retrograde extension relationship: part_of GO:0003391 ! amphid sensory organ dendrite retrograde extension created_by: dph creation_date: 2009-12-09T09:52:18Z [Term] id: GO:0003398 name: glial cell differentiation involved in amphid sensory organ development namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell of the amphid sensory organ." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003386 ! amphid sensory organ development is_a: GO:0010001 ! glial cell differentiation created_by: dph creation_date: 2009-12-09T09:55:27Z [Term] id: GO:0003399 name: cytoneme morphogenesis namespace: biological_process def: "The process by which the anatomical structures of a cytoneme are shaped. A cytoneme is a long, thin and polarized actin-based cytoplasmic extension that projects from a cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048858 ! cell projection morphogenesis created_by: dph creation_date: 2009-12-09T10:03:32Z [Term] id: GO:0003400 name: regulation of COPII vesicle coating namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the addition of COPII proteins and adaptor proteins to ER membranes during the formation of transport vesicles, forming a vesicle coat." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb] is_a: GO:0033043 ! regulation of organelle organization is_a: GO:0048209 ! regulation of vesicle targeting, to, from or within Golgi is_a: GO:0090113 ! regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0048208 ! COPII vesicle coating relationship: regulates GO:0048208 ! COPII vesicle coating created_by: dph creation_date: 2009-12-17T08:38:14Z [Term] id: GO:0003401 name: axis elongation namespace: biological_process def: "The developmental growth that results in the elongation of a line that defines polarity or symmetry in an anatomical structure." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "elongation of an axis" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis created_by: dph creation_date: 2009-12-21T01:12:15Z [Term] id: GO:0003402 name: planar cell polarity pathway involved in axis elongation namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal to modulate cytoskeletal elements and control cell polarity that contributes to axis elongation." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway relationship: part_of GO:0003401 ! axis elongation created_by: dph creation_date: 2009-12-21T01:22:11Z [Term] id: GO:0003403 name: optic vesicle formation namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic vesicle from the lateral wall of the forebrain. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis relationship: part_of GO:0060900 ! embryonic camera-type eye formation created_by: dph creation_date: 2009-12-21T01:42:37Z [Term] id: GO:0003404 name: optic vesicle morphogenesis namespace: biological_process def: "The developmental process pertaining to the formation and shaping of the optic vesicle. This process begins with the specific processes that contribute to the appearance of the vesicle and ends when the vesicle has evaginated. The optic vesicle is the evagination of neurectoderm that precedes formation of the optic cup." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048596 ! embryonic camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T01:54:34Z [Term] id: GO:0003405 name: optic vesicle elongation namespace: biological_process def: "The developmental growth that results in the lengthening of the optic vesicle in the posterior direction." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0003404 ! optic vesicle morphogenesis created_by: dph creation_date: 2009-12-21T01:59:50Z [Term] id: GO:0003406 name: retinal pigment epithelium development namespace: biological_process def: "The progression of the retinal pigment epithelium over time, from its initial formation to the mature structure. The retinal pigment epithelium is the melanin-containing layer of cells between the retina and the choroid that absorbs scattered and reflected light and removes waste products produced by the photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "RPE development" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060429 ! epithelium development relationship: part_of GO:0060041 ! retina development in camera-type eye created_by: dph creation_date: 2009-12-21T02:04:27Z [Term] id: GO:0003407 name: neural retina development namespace: biological_process def: "The progression of the neural retina over time from its initial formation to the mature structure. The neural retina is the part of the retina that contains neurons and photoreceptor cells." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0060041 ! retina development in camera-type eye created_by: dph creation_date: 2009-12-21T02:15:14Z [Term] id: GO:0003408 name: optic cup formation involved in camera-type eye development namespace: biological_process def: "The developmental process pertaining to the initial formation of the optic cup, a two-walled vesicle formed from the optic vesicle." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development created_by: dph creation_date: 2009-12-21T02:37:12Z [Term] id: GO:0003409 name: optic cup structural organization namespace: biological_process def: "The process that contributes to creating the structural organization of the optic cup. This process pertains to the physical shaping of the rudimentary structure." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0002072 ! optic cup morphogenesis involved in camera-type eye development created_by: dph creation_date: 2009-12-21T02:44:20Z [Term] id: GO:0003410 name: anterior rotation of the optic cup namespace: biological_process def: "A 90 degree-rotation of the optic cup resulting in its alignment with the anterior-posterior body axis." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0043010 ! camera-type eye development created_by: dph creation_date: 2009-12-21T02:49:48Z [Term] id: GO:0003411 name: cell motility involved in camera-type eye morphogenesis namespace: biological_process def: "Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another and contributes to the physical shaping or formation of the camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048870 ! cell motility relationship: part_of GO:0048593 ! camera-type eye morphogenesis created_by: dph creation_date: 2009-12-21T03:04:27Z [Term] id: GO:0003412 name: establishment of epithelial cell apical/basal polarity involved in camera-type eye morphogenesis namespace: biological_process def: "The specification and formation of the apicobasal polarity of an epithelial cell that contributes to the shaping of a camera-type eye." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0045198 ! establishment of epithelial cell apical/basal polarity created_by: dph creation_date: 2009-12-21T03:09:23Z [Term] id: GO:0003413 name: chondrocyte differentiation involved in endochondral bone morphogenesis namespace: biological_process def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the development of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002062 ! chondrocyte differentiation relationship: part_of GO:0060351 ! cartilage development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:39:58Z [Term] id: GO:0003414 name: chondrocyte morphogenesis involved in endochondral bone morphogenesis namespace: biological_process def: "The process by which the structures of a chondrocyte that will contribute to bone development are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0090171 ! chondrocyte morphogenesis relationship: part_of GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:42:55Z [Term] id: GO:0003415 name: chondrocyte hypertrophy namespace: biological_process def: "The growth of a chondrocyte, where growth contributes to the progression of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0048588 ! developmental cell growth relationship: part_of GO:0002063 ! chondrocyte development created_by: dph creation_date: 2009-12-22T08:48:44Z [Term] id: GO:0003416 name: endochondral bone growth namespace: biological_process def: "The increase in size or mass of an endochondral bone that contributes to the shaping of the bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060560 ! developmental growth involved in morphogenesis relationship: part_of GO:0060350 ! endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T08:52:55Z [Term] id: GO:0003417 name: growth plate cartilage development namespace: biological_process def: "The process whose specific outcome is the progression of the cartilage that will provide a scaffold for mineralization of endochondral bones as they elongate or grow." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060351 ! cartilage development involved in endochondral bone morphogenesis relationship: part_of GO:0003416 ! endochondral bone growth created_by: dph creation_date: 2009-12-22T08:57:42Z [Term] id: GO:0003418 name: growth plate cartilage chondrocyte differentiation namespace: biological_process def: "The process whereby a chondroblast acquires specialized structural and/or functional features of a chondrocyte that will contribute to the growth of a bone. A chondrocyte is a polymorphic cell that forms cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:00:56Z [Term] id: GO:0003419 name: growth plate cartilage chondrocyte proliferation namespace: biological_process def: "The multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:02:51Z [Term] id: GO:0003420 name: regulation of growth plate cartilage chondrocyte proliferation namespace: biological_process def: "Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of chondrocytes in a growing endochondral bone, resulting in the expansion of a cell population." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0061035 ! regulation of cartilage development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation relationship: regulates GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2009-12-22T09:07:40Z [Term] id: GO:0003421 name: growth plate cartilage axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the columnar cartilage along the axis of a long bone that contributes to bone growth." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T09:16:33Z [Term] id: GO:0003422 name: growth plate cartilage morphogenesis namespace: biological_process def: "The process by which the anatomical structures of cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0060536 ! cartilage morphogenesis relationship: part_of GO:0003417 ! growth plate cartilage development created_by: dph creation_date: 2009-12-22T09:21:30Z [Term] id: GO:0003423 name: growth plate cartilage chondrocyte division namespace: biological_process def: "The process resulting in the oriented physical partitioning and separation of a chondrocytes in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0051301 ! cell division relationship: part_of GO:0003419 ! growth plate cartilage chondrocyte proliferation created_by: dph creation_date: 2009-12-22T09:55:51Z [Term] id: GO:0003424 name: establishment of cell polarity involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization that results in the directional division of a growth plate cartilage chondrocyte." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte polarization" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0001736 ! establishment of planar polarity is_a: GO:0030010 ! establishment of cell polarity relationship: part_of GO:0003423 ! growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T10:18:10Z [Term] id: GO:0003425 name: establishment of spindle orientation involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A cell cycle process that sets the alignment of mitotic spindle relative to other cellular structures and contributes to oriented chondrocyte division in the growth plate." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0000132 ! establishment of mitotic spindle orientation is_a: GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T10:36:36Z [Term] id: GO:0003426 name: cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "A process that is carried out at the cellular level which results in the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0007010 ! cytoskeleton organization relationship: part_of GO:0003424 ! establishment of cell polarity involved in growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T11:38:22Z [Term] id: GO:0003427 name: regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell that modulates the rate, frequency, or extent of the polarization of cytoskeletal structures in a growth plate cartilage chondrocyte. This process results in the oriented division of the cell." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "regulation of cytoskeleton polarization involved in growth plate cartilage chondrocyte division by planar cell polarity pathway" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003420 ! regulation of growth plate cartilage chondrocyte proliferation is_a: GO:0032878 ! regulation of establishment or maintenance of cell polarity is_a: GO:0051302 ! regulation of cell division is_a: GO:0051493 ! regulation of cytoskeleton organization is_a: GO:0060071 ! Wnt receptor signaling pathway, planar cell polarity pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division relationship: regulates GO:0003426 ! cytoskeleton polarization involved in growth plate cartilage chondrocyte division created_by: dph creation_date: 2009-12-22T11:43:29Z [Term] id: GO:0003428 name: chondrocyte intercalation involved in growth plate cartilage morphogenesis namespace: biological_process def: "The orderly movement of a chondrocyte from one site to another that contributes to the shaping of growth plate cartilage in an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0016477 ! cell migration is_a: GO:0060026 ! convergent extension relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T11:52:32Z [Term] id: GO:0003429 name: growth plate cartilage chondrocyte morphogenesis namespace: biological_process def: "The process by which the structures of a chondrocyte in the growth plate cartilage are generated and organized." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003414 ! chondrocyte morphogenesis involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation created_by: dph creation_date: 2009-12-22T12:22:24Z [Term] id: GO:0003430 name: growth plate cartilage chondrocyte growth namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the progression of the chondrocyte over time from one condition to another." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "growth plate cartilage chondrocyte hypertrophy" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003415 ! chondrocyte hypertrophy relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T12:29:19Z [Term] id: GO:0003431 name: growth plate cartilage chondrocyte development namespace: biological_process def: "The progression of a growth plate cartilage chondrocyte over time from after its fate commitment to the mature cell." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003433 ! chondrocyte development involved in endochondral bone morphogenesis relationship: part_of GO:0003418 ! growth plate cartilage chondrocyte differentiation created_by: dph creation_date: 2009-12-22T12:32:49Z [Term] id: GO:0003432 name: cell growth involved in growth plate cartilage chondrocyte morphogensis namespace: biological_process def: "The growth of a growth plate cartilage chondrocyte, where growth contributes to the shaping of the chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003430 ! growth plate cartilage chondrocyte growth relationship: part_of GO:0003429 ! growth plate cartilage chondrocyte morphogenesis created_by: dph creation_date: 2009-12-22T12:37:48Z [Term] id: GO:0003433 name: chondrocyte development involved in endochondral bone morphogenesis namespace: biological_process def: "The progression of a chondrocyte over time from after its commitment to its mature state where the chondrocyte will contribute to the shaping of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0002063 ! chondrocyte development relationship: part_of GO:0003413 ! chondrocyte differentiation involved in endochondral bone morphogenesis created_by: dph creation_date: 2009-12-22T12:42:44Z [Term] id: GO:0003434 name: BMP signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "A series of molecular signals generated as a consequence of any member of the BMP (bone morphogenetic protein) family binding to a cell surface receptor that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030509 ! BMP signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T12:50:17Z [Term] id: GO:0003435 name: smoothened signaling pathway involved in growth plate cartilage chondrocyte development namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened that contributes to the progression of a growth plate cartilage chondrocyte over time." [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "hedgehog signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] synonym: "hh signaling pathway involved in growth plate cartilage chondrocyte development" EXACT [GOC:bf, GOC:ecd] is_a: GO:0007224 ! smoothened signaling pathway relationship: part_of GO:0003431 ! growth plate cartilage chondrocyte development created_by: dph creation_date: 2009-12-22T01:02:42Z [Term] id: GO:0003436 name: regulation of cell adhesion involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of attachment of a cell to another cell or to the extracellular matrix and contributes to the shaping of the growth plate cartilage of an endochondral bone." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0030155 ! regulation of cell adhesion relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T01:28:15Z [Term] id: GO:0003437 name: regulation of cell communication involved in growth plate cartilage morphogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell communication that contributes to the shaping of the growth plate cartilage." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication relationship: part_of GO:0003422 ! growth plate cartilage morphogenesis created_by: dph creation_date: 2009-12-22T01:34:24Z [Term] id: GO:0003673 name: Gene_Ontology namespace: biological_process def: "OBSOLETE. A controlled vocabulary that can be applied to all organisms even as knowledge of gene and protein roles in cells is accumulating and changing. GO provides three structured networks of defined terms to describe gene product attributes." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true [Term] id: GO:0003674 name: molecular_function namespace: molecular_function alt_id: GO:0005554 def: "Elemental activities, such as catalysis or binding, describing the actions of a gene product at the molecular level. A given gene product may exhibit one or more molecular functions." [GOC:go_curators] comment: Note that, in addition to forming the root of the molecular function ontology, this term is recommended for use for the annotation of gene products whose molecular function is unknown. Note that when this term is used for annotation, it indicates that no information was available about the molecular function of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "molecular function" EXACT [] synonym: "molecular function unknown" NARROW [] [Term] id: GO:0003675 name: protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0003676 name: nucleic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with any nucleic acid." [GOC:jl] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0003677 name: DNA binding namespace: molecular_function def: "Any molecular function by which a gene product interacts selectively with DNA (deoxyribonucleic acid)." [GOC:dph, GOC:jl, GOC:tb] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "microtubule/chromatin interaction" RELATED [] synonym: "plasmid binding" NARROW [] is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003678 name: DNA helicase activity namespace: molecular_function alt_id: GO:0003679 def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA helix." [GOC:jl, GOC:mah, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok is_a: GO:0004386 ! helicase activity [Term] id: GO:0003680 name: AT DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with oligo(A) and oligo(T) tracts of DNA (AT DNA)." [GOC:jl, PMID:2670564] synonym: "AT binding" EXACT [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003681 name: bent DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in a bent conformation." [GOC:jl, PMID:12627977] subset: gosubset_prok is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003682 name: chromatin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chromatin, the network of fibers of DNA and protein that make up the chromosomes of the eukaryotic nucleus during interphase." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant synonym: "lamin/chromatin binding" BROAD [] synonym: "microtubule/chromatin interaction" RELATED [] synonym: "nuclear membrane vesicle binding to chromatin" NARROW [] is_a: GO:0005488 ! binding [Term] id: GO:0003683 name: lamin/chromatin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two functions. is_obsolete: true replaced_by: GO:0003682 replaced_by: GO:0005521 [Term] id: GO:0003684 name: damaged DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with damaged DNA." [GOC:jl] subset: gosubset_prok synonym: "DNA repair enzyme" RELATED [] synonym: "DNA repair protein" RELATED [] xref: Reactome:7372 "damaged DNA binding" is_a: GO:0003677 ! DNA binding [Term] id: GO:0003685 name: DNA repair protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003686 name: DNA repair enzyme namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:elh] comment: This term was made obsolete because it includes a process term. is_obsolete: true consider: GO:0003684 [Term] id: GO:0003687 name: DNA replication factor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it does not represent a true molecular function. is_obsolete: true consider: GO:0006260 [Term] id: GO:0003688 name: DNA replication origin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "ARS binding" NARROW [] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003689 name: DNA clamp loader activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the opening of the ring structure of the PCNA complex, or any of the related sliding clamp complexes, and their closing around the DNA duplex." [GOC:mah, GOC:vw, PMID:16082778] subset: gosubset_prok synonym: "DNA clamp loading ATPase activity" EXACT [] synonym: "PCNA loading activity" NARROW [] synonym: "PCNA loading complex activity" NARROW [] xref: Reactome:9823 "DNA clamp loader activity" is_a: GO:0003677 ! DNA binding is_a: GO:0033170 ! protein-DNA loading ATPase activity [Term] id: GO:0003690 name: double-stranded DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded DNA." [GOC:elh] subset: gosubset_prok synonym: "dsDNA binding" EXACT [GOC:elh] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003691 name: double-stranded telomeric DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded telomere-associated DNA." [GOC:jl, ISBN:0321000382] is_a: GO:0003690 ! double-stranded DNA binding is_a: GO:0042162 ! telomeric DNA binding [Term] id: GO:0003692 name: left-handed Z-DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with DNA in the Z form, i.e. a left-handed helix in which the phosphate backbone zigzags." [ISBN:0716720094] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003693 name: P-element binding namespace: molecular_function def: "Interacting selectively and non-covalently with any P-element, a class of Drosophila transposon responsible for hybrid dysgenesis." [GOC:jl, http://cancerweb.ncl.ac.uk/] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003694 name: plasmid binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a plasmid, an extrachromosomal genetic element usually characterized as a covalently continuous double stranded DNA molecule found in bacteria and some other microorganisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to component information. synonym: "plasmid-associated protein" RELATED [] is_obsolete: true consider: GO:0003677 consider: GO:0005727 [Term] id: GO:0003695 name: random coil DNA binding namespace: molecular_function alt_id: GO:0016017 def: "Interacting selectively and non-covalently with DNA in a random coil configuration." [GOC:mah] synonym: "random coil binding" EXACT [] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003696 name: satellite DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with satellite DNA, the many tandem repeats (identical or related) of a short basic repeating unit; many have a base composition or other property different from the genome average that allows them to be separated from the bulk (main band) genomic DNA." [GOC:jl, SO:0000005] is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0003697 name: single-stranded DNA binding namespace: molecular_function alt_id: GO:0003698 alt_id: GO:0003699 def: "Interacting selectively and non-covalently with single-stranded DNA." [GOC:elh] comment: Note that this term is restricted to those cases where the binding is to a single-stranded DNA molecule, not to one of the stands of double-stranded DNA. subset: gosubset_prok synonym: "ssDNA binding" EXACT [GOC:mah] is_a: GO:0043566 ! structure-specific DNA binding [Term] id: GO:0003700 name: transcription factor activity namespace: molecular_function alt_id: GO:0000130 def: "The function of binding to a specific DNA sequence in order to modulate transcription. The transcription factor may or may not also interact selectively with a protein or macromolecular complex." [GOC:curators] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0003677 ! DNA binding is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0003701 name: RNA polymerase I transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase I transcription." [GOC:jl] is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0003702 name: RNA polymerase II transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase II transcription." [GOC:jl] is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0003704 name: specific RNA polymerase II transcription factor activity namespace: molecular_function def: "Functions to enable the transcription of specific, or specific sets, of genes by RNA polymerase II." [GOC:ma] is_a: GO:0003702 ! RNA polymerase II transcription factor activity [Term] id: GO:0003705 name: RNA polymerase II transcription factor activity, enhancer binding namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase II transcription by binding an enhancer region of DNA." [GOC:jl] is_a: GO:0003700 ! transcription factor activity is_a: GO:0003702 ! RNA polymerase II transcription factor activity is_a: GO:0035326 ! enhancer binding [Term] id: GO:0003706 name: ligand-regulated transcription factor activity namespace: molecular_function is_a: GO:0003704 ! specific RNA polymerase II transcription factor activity [Term] id: GO:0003707 name: steroid hormone receptor activity namespace: molecular_function def: "Combining with a steroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity relationship: part_of GO:0043401 ! steroid hormone mediated signaling pathway [Term] id: GO:0003708 name: retinoic acid receptor activity namespace: molecular_function def: "Combining with retinoic acid to initiate a change in cell activity. Retinoic acid is one of the forms of vitamin A." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "vitamin A receptor activity" BROAD [] is_a: GO:0004879 ! ligand-dependent nuclear receptor activity relationship: part_of GO:0048384 ! retinoic acid receptor signaling pathway [Term] id: GO:0003709 name: RNA polymerase III transcription factor activity namespace: molecular_function def: "Functions to initiate or regulate RNA polymerase III transcription." [GOC:jl] is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0003711 name: transcription elongation regulator activity namespace: molecular_function def: "Any activity that modulates the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] subset: gosubset_prok synonym: "transcription elongation factor activity" EXACT [] synonym: "transcriptional elongation regulator activity" EXACT [] is_a: GO:0030528 ! transcription regulator activity relationship: part_of GO:0032784 ! regulation of RNA elongation [Term] id: GO:0003712 name: transcription cofactor activity namespace: molecular_function def: "The function that links a sequence-specific transcription factor to the core RNA polymerase II complex but does not bind DNA itself." [PMID:10213677] subset: gosubset_prok synonym: "transcriptional co-regulator" EXACT [] synonym: "transcriptional cofactor activity" EXACT [] is_a: GO:0008134 ! transcription factor binding is_a: GO:0030528 ! transcription regulator activity [Term] id: GO:0003713 name: transcription coactivator activity namespace: molecular_function def: "The function of a transcription cofactor that activates transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] subset: gosubset_prok synonym: "transcription co-activator activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity is_a: GO:0016563 ! transcription activator activity [Term] id: GO:0003714 name: transcription corepressor activity namespace: molecular_function def: "The function of a transcription cofactor that represses transcription from a RNA polymerase II promoter; does not bind DNA itself." [GOC:ma] synonym: "transcription co-repressor activity" EXACT [] is_a: GO:0003712 ! transcription cofactor activity is_a: GO:0016564 ! transcription repressor activity [Term] id: GO:0003715 name: transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription." [GOC:mah] subset: gosubset_prok synonym: "transcriptional termination factor activity" EXACT [] is_a: GO:0030528 ! transcription regulator activity relationship: part_of GO:0031554 ! regulation of transcription termination [Term] id: GO:0003716 name: RNA polymerase I transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase I." [GOC:mah] synonym: "Pol I transcription termination factor activity" EXACT [] is_a: GO:0003715 ! transcription termination factor activity [Term] id: GO:0003717 name: RNA polymerase II transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase II." [GOC:mah] synonym: "Pol II transcription termination factor activity" EXACT [] is_a: GO:0003715 ! transcription termination factor activity [Term] id: GO:0003718 name: RNA polymerase III transcription termination factor activity namespace: molecular_function def: "Any activity that brings about termination of transcription by RNA polymerase III." [GOC:mah] synonym: "Pol III transcription termination factor activity" EXACT [] is_a: GO:0003715 ! transcription termination factor activity [Term] id: GO:0003719 name: transcription factor binding, cytoplasmic sequestering namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process rather than a function. is_obsolete: true replaced_by: GO:0042994 [Term] id: GO:0003720 name: telomerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:krc] xref: EC:2.7.7.- xref: Reactome:10567 "telomerase activity" is_a: GO:0003964 ! RNA-directed DNA polymerase activity [Term] id: GO:0003721 name: telomeric template RNA reverse transcriptase activity namespace: molecular_function def: "Catalysis of the extension of the 3' end of a DNA strand by one deoxynucleotide at a time. Cannot initiate a chain de novo; uses the RNA subunit of the telomerase enzyme complex as its template." [EC:2.7.7.49, PMID:11812242] synonym: "telomerase, catalyst" EXACT [] is_a: GO:0003964 ! RNA-directed DNA polymerase activity relationship: part_of GO:0003720 ! telomerase activity [Term] id: GO:0003723 name: RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with an RNA molecule or a portion thereof." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Reactome:1805 "RNA binding" is_a: GO:0003676 ! nucleic acid binding [Term] id: GO:0003724 name: RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a RNA helix." [GOC:jl, GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- xref: Reactome:7008 "RNA helicase activity" is_a: GO:0004386 ! helicase activity [Term] id: GO:0003725 name: double-stranded RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded RNA." [GOC:jl] subset: gosubset_prok synonym: "dsRNA binding" EXACT [GOC:ecd] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003726 name: double-stranded RNA adenosine deaminase activity namespace: molecular_function alt_id: GO:0003971 def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a double-stranded RNA molecule." [GOC:mah] subset: gosubset_prok synonym: "double-stranded RNA specific editase activity" RELATED [] xref: Reactome:10576 "double-stranded RNA adenosine deaminase activity" is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0003727 name: single-stranded RNA binding namespace: molecular_function alt_id: GO:0003728 def: "Interacting selectively and non-covalently with single-stranded RNA." [GOC:jl] synonym: "ssRNA binding" EXACT [GOC:mah] is_a: GO:0003723 ! RNA binding [Term] id: GO:0003729 name: mRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with pre-messenger RNA (pre-mRNA) or messenger RNA (mRNA)." [GOC:jl] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0003730 name: mRNA 3'-UTR binding namespace: molecular_function def: "Interacting selectively and non-covalently with the 3' untranslated region of an mRNA molecule." [GOC:mah] synonym: "mRNA 3' UTR binding" EXACT [] is_a: GO:0003729 ! mRNA binding [Term] id: GO:0003731 name: mRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the 7-methylguanosine cap at the 5' end of a nascent messenger RNA transcript." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003732 name: snRNA cap binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with the cap structure at the 5' end of a small nuclear RNA molecule." [GOC:mah] comment: This term was made obsolete because the functional distinction for cap binding is the structure of the cap, not the type of RNA it is attached to. is_obsolete: true consider: GO:0000339 [Term] id: GO:0003733 name: ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. is_obsolete: true replaced_by: GO:0030529 [Term] id: GO:0003734 name: small nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "snRNP" EXACT [] is_obsolete: true replaced_by: GO:0030532 [Term] id: GO:0003735 name: structural constituent of ribosome namespace: molecular_function alt_id: GO:0003736 alt_id: GO:0003737 alt_id: GO:0003738 alt_id: GO:0003739 alt_id: GO:0003740 alt_id: GO:0003741 alt_id: GO:0003742 def: "The action of a molecule that contributes to the structural integrity of the ribosome." [GOC:mah] comment: Note that this term may be used to annotate ribosomal RNAs as well as ribosomal proteins. subset: gosubset_prok synonym: "ribosomal protein" BROAD [] synonym: "ribosomal RNA" RELATED [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0003743 name: translation initiation factor activity namespace: molecular_function alt_id: GO:0003744 alt_id: GO:0003745 def: "Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:10611 "translation initiation factor activity" is_a: GO:0008135 ! translation factor activity, nucleic acid binding relationship: part_of GO:0006413 ! translational initiation relationship: part_of GO:0045948 ! positive regulation of translational initiation [Term] id: GO:0003746 name: translation elongation factor activity namespace: molecular_function alt_id: GO:0008182 alt_id: GO:0008183 def: "Functions in chain elongation during polypeptide synthesis at the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:10616 "translation elongation factor activity" is_a: GO:0008135 ! translation factor activity, nucleic acid binding relationship: part_of GO:0006414 ! translational elongation [Term] id: GO:0003747 name: translation release factor activity namespace: molecular_function alt_id: GO:0003748 alt_id: GO:0003749 def: "Involved in catalyzing the release of a nascent polypeptide chain from a ribosome." [ISBN:0198547684] subset: gosubset_prok is_a: GO:0008079 ! translation termination factor activity [Term] id: GO:0003750 name: cell cycle regulator namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a single molecular function. is_obsolete: true replaced_by: GO:0051726 [Term] id: GO:0003754 name: chaperone activity namespace: molecular_function alt_id: GO:0003757 alt_id: GO:0003758 alt_id: GO:0003760 alt_id: GO:0003761 def: "OBSOLETE. Assists in the correct non-covalent assembly of polypeptide-containing structures in vivo, but is not a component of these assembled structures when they are performing their normal biological function." [ISBN:0198547684] comment: This term was made obsolete because, as defined, it represents a class of gene products rather than a molecular function. The term string is also ambiguous, having connotations of involvement in transport processes. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003755 name: peptidyl-prolyl cis-trans isomerase activity namespace: molecular_function alt_id: GO:0004752 alt_id: GO:0042028 def: "Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0)." [EC:5.2.1.8] subset: gosubset_prok synonym: "cis-trans proline isomerase activity" EXACT [] synonym: "cyclophilin activity" RELATED [EC:5.2.1.8] synonym: "cyclophilin-type peptidyl-prolyl cis-trans isomerase activity" NARROW [] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" NARROW [] synonym: "immunophilin" RELATED [] synonym: "juglone-sensitive cis-trans proline isomerase activity" NARROW [GOC:mah] synonym: "juglone-sensitive peptidyl-prolyl cis-trans isomerase activity" NARROW [GOC:mah] synonym: "parvulin" RELATED [] synonym: "peptide bond isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidyl-prolyl isomerase B reaction" RELATED [] synonym: "peptidylproline cis-trans-isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl cis-trans isomerase activity" EXACT [EC:5.2.1.8] synonym: "peptidylprolyl isomerase activity" EXACT [EC:5.2.1.8] synonym: "PPIase activity" EXACT [EC:5.2.1.8] synonym: "rotamase activity" EXACT [EC:5.2.1.8] xref: EC:5.2.1.8 xref: MetaCyc:PEPTIDYLPROLYL-ISOMERASE-RXN is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0003756 name: protein disulfide isomerase activity namespace: molecular_function def: "Catalysis of the rearrangement of both intrachain and interchain disulfide bonds in proteins." [EC:5.3.4.1] subset: gosubset_prok synonym: "protein cysteine-thiol oxidation" RELATED [] synonym: "protein disulfide-isomerase" BROAD [EC:5.3.4.1] synonym: "protein disulfide-isomerase reaction" EXACT [EC:5.3.4.1] synonym: "protein disulphide isomerase activity" EXACT [] synonym: "S-S rearrangase activity" RELATED [EC:5.3.4.1] xref: EC:5.3.4.1 xref: MetaCyc:5.3.4.1-RXN is_a: GO:0016862 ! intramolecular oxidoreductase activity, interconverting keto- and enol-groups is_a: GO:0016864 ! intramolecular oxidoreductase activity, transposing S-S bonds [Term] id: GO:0003759 name: glycoprotein-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in the correct, non-covalent assembly of glycoproteins in vivo, but is not a component of the assembled structures when performing its normal biological function. Utilizes a lectin site as a means to associate with the unfolded glycoproteins." [GOC:jl, PMID:11337494] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003762 name: histone-specific chaperone activity namespace: molecular_function def: "OBSOLETE. Assists in chromatin assembly by chaperoning histones on to replicating DNA, but is not a component of the assembled nucleosome when performing its normal biological function." [GOC:jl, PMID:7600578, PMID:9325046] comment: This term was made obsolete because it represents a class of gene products and a biological process rather than a molecular function. synonym: "nucleosome assembly chaperone" EXACT [] is_obsolete: true consider: GO:0006333 consider: GO:0006334 consider: GO:0034728 consider: GO:0042393 consider: GO:0043486 consider: GO:0044183 consider: GO:0051082 [Term] id: GO:0003763 name: chaperonin ATPase activity namespace: molecular_function alt_id: GO:0003764 alt_id: GO:0003765 alt_id: GO:0003766 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP involved in maintaining an unfolded polypeptide structure before folding or to entry into mitochondria and chloroplasts." [EC:3.6.4.9, ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. synonym: "chaperonin" EXACT [] is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0003767 name: co-chaperone activity namespace: molecular_function alt_id: GO:0003768 alt_id: GO:0003769 alt_id: GO:0003770 alt_id: GO:0003771 def: "OBSOLETE. Co-chaperones are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperones by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003772 name: co-chaperonin activity namespace: molecular_function def: "OBSOLETE. Co-chaperonins are proteins that bind to chaperones and this complex then folds misfolded proteins. Co-chaperonins by themselves do not possess chaperone activity." [GOC:rb] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006457 consider: GO:0044183 consider: GO:0051087 [Term] id: GO:0003773 name: heat shock protein activity namespace: molecular_function def: "OBSOLETE. Any of a group of specific proteins that are synthesized by both prokaryotic and eukaryotic cells after they have been exposed to a temperature that is higher than normal. Other stresses, e.g. free radical damage, have a similar effect. Many members of the hsp family are not induced but are present in all cells. They are characterized by their role as molecular chaperones." [ISBN:0198547684] comment: This term was made obsolete because it represents a class of gene products rather than a molecular function. is_obsolete: true consider: GO:0006986 consider: GO:0042026 [Term] id: GO:0003774 name: motor activity namespace: molecular_function def: "Catalysis of movement along a polymeric molecule such as a microfilament or microtubule, coupled to the hydrolysis of a nucleoside triphosphate." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0003775 name: axonemal motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. is_obsolete: true consider: GO:0003777 consider: GO:0005930 [Term] id: GO:0003776 name: muscle motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes anatomy information. is_obsolete: true replaced_by: GO:0000146 consider: GO:0006936 consider: GO:0043292 [Term] id: GO:0003777 name: microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule, coupled to the hydrolysis of a nucleoside triphosphate (usually ATP)." [GOC:mah, ISBN:0815316194] comment: Consider also annotating to the molecular function term 'microtubule binding ; GO:0008017'. synonym: "axonemal motor activity" NARROW [] synonym: "dynein" BROAD [] synonym: "dynein ATPase activity" NARROW [] synonym: "kinesin" BROAD [] synonym: "kinesin motor activity" NARROW [] synonym: "kinetochore motor activity" NARROW [] xref: Reactome:10659 "microtubule motor activity" is_a: GO:0003774 ! motor activity [Term] id: GO:0003778 name: dynactin motor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because the dynactin complex is not a motor as such, but does regulate the dynein motor complex. is_obsolete: true [Term] id: GO:0003779 name: actin binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric or multimeric forms of actin, including actin filaments." [GOC:clt] subset: goslim_generic synonym: "membrane associated actin binding" NARROW [] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0003780 name: actin cross-linking activity namespace: molecular_function def: "OBSOLETE. Interacting selectively with two actin filaments to anchor them together." [GOC:jid] comment: This term was made obsolete because it represents a combination of molecular functions. is_obsolete: true replaced_by: GO:0030674 replaced_by: GO:0051015 [Term] id: GO:0003781 name: actin bundling activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0051017 [Term] id: GO:0003782 name: F-actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003783 name: barbed-end actin capping activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051016 [Term] id: GO:0003784 name: barbed-end actin capping/severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes two biological processes. is_obsolete: true replaced_by: GO:0051014 replaced_by: GO:0051016 [Term] id: GO:0003785 name: actin monomer binding namespace: molecular_function def: "Interacting selectively and non-covalently with monomeric actin, also known as G-actin." [GOC:ai] synonym: "G actin binding" EXACT [] is_a: GO:0003779 ! actin binding [Term] id: GO:0003786 name: actin lateral binding namespace: molecular_function def: "Interacting selectively and non-covalently with an actin filament along its length." [GOC:mah] is_a: GO:0051015 ! actin filament binding [Term] id: GO:0003787 name: actin depolymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0030042 [Term] id: GO:0003788 name: actin monomer sequestering activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because sequestering is a process, not an activity. is_obsolete: true replaced_by: GO:0042989 [Term] id: GO:0003789 name: actin filament severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0051014 [Term] id: GO:0003790 name: actin modulating activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not make sense. is_obsolete: true consider: GO:0030036 [Term] id: GO:0003791 name: membrane associated actin binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0003779 consider: GO:0016020 [Term] id: GO:0003792 name: regulation of actin thin filament length activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the term belongs in the process ontology. is_obsolete: true replaced_by: GO:0030832 [Term] id: GO:0003793 name: defense/immunity protein activity namespace: molecular_function def: "OBSOLETE. Any activity that plays a role in the defense/immune response of an organism against infection and disease." [GOC:go_curators] comment: This term was made obsolete because it refers to involvement in a biological process. synonym: "defence/immunity protein activity" EXACT [] is_obsolete: true consider: GO:0006952 [Term] id: GO:0003794 name: acute-phase response protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006953 [Term] id: GO:0003795 name: antimicrobial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, microbial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0006952 [Term] id: GO:0003796 name: lysozyme activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 1,4-beta-linkages between N-acetyl-D-glucosamine and N-acetylmuramic acid in peptidoglycan heteropolymers of the prokaryotes cell walls and between N-acetyl-D-glucosamine residues in chitodextrins." [EC:3.2.1.17] subset: gosubset_prok synonym: "1,4-N-acetylmuramidase activity" EXACT [] synonym: "globulin G" RELATED [EC:3.2.1.17] synonym: "globulin G1" RELATED [EC:3.2.1.17] synonym: "L-7001" RELATED [EC:3.2.1.17] synonym: "lysozyme g" RELATED [EC:3.2.1.17] synonym: "mucopeptide glucohydrolase activity" EXACT [] synonym: "mucopeptide N-acetylmuramoylhydrolase activity" EXACT [] synonym: "muramidase activity" EXACT [] synonym: "N,O-diacetylmuramidase activity" EXACT [] synonym: "peptidoglycan N-acetylmuramoylhydrolase activity" EXACT [EC:3.2.1.17] synonym: "PR1-lysozyme" RELATED [EC:3.2.1.17] xref: EC:3.2.1.17 xref: MetaCyc:3.2.1.17-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003797 name: antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0042742 [Term] id: GO:0003798 name: male-specific antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, bacterial cells, but which is only expressed in males." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050831 [Term] id: GO:0003799 name: antifungal peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, fungal cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050832 [Term] id: GO:0003800 name: antiviral response protein activity namespace: molecular_function def: "OBSOLETE. A protein involved in an antiviral response." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0009615 [Term] id: GO:0003801 name: blood coagulation factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0004252 consider: GO:0007596 [Term] id: GO:0003802 name: coagulation factor VIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of one Arg-Ile bond in factor X to form factor Xa, and on factor IX to form factor IXa beta." [EC:3.4.21.21, PMID:12496253] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor VII" RELATED [EC:3.4.21.21] synonym: "blood coagulation factor VII activity" EXACT [] synonym: "blood-coagulation factor VIIa" RELATED [EC:3.4.21.21] xref: EC:3.4.21.21 xref: MetaCyc:3.4.21.21-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003803 name: coagulation factor IXa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of the Arg-Ile bond in factor X to form factor Xa." [EC:3.4.21.22] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XI" RELATED [EC:3.4.21.22] synonym: "activated blood-coagulation factor IX" RELATED [EC:3.4.21.22] synonym: "activated christmas factor" RELATED [EC:3.4.21.22] synonym: "autoprothrombin II" RELATED [EC:3.4.21.22] synonym: "blood coagulation factor IX activity" EXACT [] synonym: "blood platelet cofactor II" RELATED [EC:3.4.21.22] synonym: "blood-coagulation factor IXa" RELATED [EC:3.4.21.22] synonym: "Christmas factor activity" EXACT [EC:3.4.21.22] xref: EC:3.4.21.22 xref: MetaCyc:3.4.21.22-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003804 name: coagulation factor Xa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Thr and then Arg-Ile bonds in prothrombin to form thrombin, and on factor VII, which it converts to a two-chain form (factor VIIa)." [EC:3.4.21.6, GOC:jl, PMID:7354023] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor X" RELATED [EC:3.4.21.6] synonym: "activated factor X" RELATED [EC:3.4.21.6] synonym: "activated Stuart-Prower factor" RELATED [EC:3.4.21.6] synonym: "autoprothrombin C" RELATED [EC:3.4.21.6] synonym: "blood coagulation factor X activity" EXACT [] synonym: "factor Xa" RELATED [EC:3.4.21.6] synonym: "plasma thromboplastin" RELATED [EC:3.4.21.6] synonym: "prothrombase activity" EXACT [EC:3.4.21.6] synonym: "prothrombinase activity" EXACT [EC:3.4.21.6] synonym: "Stuart factor" RELATED [EC:3.4.21.6] synonym: "Stuart factor activity" EXACT [EC:3.4.21.6] synonym: "thrombokinase activity" EXACT [EC:3.4.21.6] synonym: "thromboplastin" RELATED [EC:3.4.21.6] xref: EC:3.4.21.6 xref: MetaCyc:3.4.21.6-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003805 name: coagulation factor XIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ala and Arg-Val bonds in factor IX to form factor IXa." [EC:3.4.21.27] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor XI" RELATED [EC:3.4.21.27] synonym: "activated plasma thromboplastin antecedent" RELATED [EC:3.4.21.27] synonym: "blood coagulation factor XI activity" EXACT [] synonym: "blood-coagulation factor XIa" RELATED [EC:3.4.21.27] synonym: "plasma thromboplastin antecedent activity" EXACT [EC:3.4.21.27] xref: EC:3.4.21.27 xref: MetaCyc:3.4.21.27-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003806 name: coagulation factor XIIa activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ile bonds in factor VII to form factor VIIa and factor XI to form factor XIa." [EC:3.4.21.38] comment: This term was made obsolete because it represents a gene product. synonym: "activated beta blood-coagulation factor XII" RELATED [EC:3.4.21.38] synonym: "blood coagulation factor XII activity" EXACT [] synonym: "blood-coagulation factor XIIabeta" RELATED [EC:3.4.21.38] synonym: "blood-coagulation factor XIIf" RELATED [EC:3.4.21.38] synonym: "hageman factor (activated)" RELATED [EC:3.4.21.38] synonym: "hageman factor activity" EXACT [EC:3.4.21.38] synonym: "hageman factor beta-fragment" RELATED [EC:3.4.21.38] synonym: "hageman factor fragment HFf" RELATED [EC:3.4.21.38] synonym: "kallikreinogen activator" RELATED [EC:3.4.21.38] synonym: "prealbumin activator" RELATED [EC:3.4.21.38] synonym: "prekallikrein activator" RELATED [EC:3.4.21.38] xref: EC:3.4.21.38 xref: MetaCyc:3.4.21.38-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003807 name: plasma kallikrein activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Xaa and Lys-Xaa bonds, including Lys-Arg and Arg-Ser bonds in (human) kininogen to release bradykinin." [EC:3.4.21.34] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.34] synonym: "callicrein" RELATED [EC:3.4.21.34] synonym: "depot-padutin" RELATED [EC:3.4.21.34] synonym: "dilminal D" RELATED [EC:3.4.21.34] synonym: "glumorin" RELATED [EC:3.4.21.34] synonym: "kallidinogenase" BROAD [EC:3.4.21.34] synonym: "kallikrein" RELATED [EC:3.4.21.34] synonym: "kallikrein I" RELATED [EC:3.4.21.34] synonym: "kallikrein II" RELATED [EC:3.4.21.34] synonym: "kininogenase" BROAD [EC:3.4.21.34] synonym: "kininogenin activity" RELATED [EC:3.4.21.34] synonym: "onokrein P" RELATED [EC:3.4.21.34] synonym: "padreatin" RELATED [EC:3.4.21.34] synonym: "padutin" RELATED [EC:3.4.21.34] synonym: "panceatic kallikrein" RELATED [EC:3.4.21.34] synonym: "serum kallikrein activity" EXACT [EC:3.4.21.34] synonym: "urinary kallikrein" RELATED [EC:3.4.21.34] synonym: "urokallikrein" RELATED [EC:3.4.21.34] xref: EC:3.4.21.34 xref: MetaCyc:3.4.21.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003808 name: protein C (activated) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of blood coagulation factors Va and VIIIa." [EC:3.4.21.69] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood coagulation factor XIV activity" EXACT [EC:3.4.21.69] synonym: "activated protein C" RELATED [EC:3.4.21.69] synonym: "autoprothrombin II-A" RELATED [EC:3.4.21.69] synonym: "autoprothrombin IIA activity" EXACT [EC:3.4.21.69] synonym: "blood-coagulation factor XIVa" RELATED [EC:3.4.21.69] synonym: "GSAPC" RELATED [EC:3.4.21.69] synonym: "protein Ca" RELATED [EC:3.4.21.69] xref: EC:3.4.21.69 xref: MetaCyc:3.4.21.69-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003809 name: thrombin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Gly; activates fibrinogen to fibrin and releases fibrinopeptide A and B." [EC:3.4.21.5] comment: This term was made obsolete because it represents a gene product. synonym: "activated blood-coagulation factor II" RELATED [EC:3.4.21.5] synonym: "beta-thrombin" RELATED [EC:3.4.21.5] synonym: "blood-coagulation factor IIa" RELATED [EC:3.4.21.5] synonym: "E thrombin" RELATED [EC:3.4.21.5] synonym: "factor IIa" RELATED [EC:3.4.21.5] synonym: "fibrinogenase activity" EXACT [EC:3.4.21.5] synonym: "gamma-thrombin" RELATED [EC:3.4.21.5] synonym: "thrombase activity" EXACT [EC:3.4.21.5] synonym: "thrombin-C" RELATED [EC:3.4.21.5] synonym: "thrombofort" RELATED [EC:3.4.21.5] synonym: "topical" RELATED [EC:3.4.21.5] synonym: "tropostasin" RELATED [EC:3.4.21.5] xref: EC:3.4.21.5 xref: MetaCyc:3.4.21.5-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003810 name: protein-glutamine gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: protein glutamine + alkylamine = protein N5-alkylglutamine + NH3. This reaction is the formation of the N6-(L-isoglutamyl)-L-lysine isopeptide, resulting in cross-linking polypeptide chains; the gamma-carboxamide groups of peptidyl-glutamine residues act as acyl donors, and the 6-amino-groups of peptidyl-lysine residues act as acceptors, to give intra- and intermolecular N6-(5-glutamyl)lysine cross-links." [EC:2.3.2.13, RESID:AA0124] subset: gosubset_prok synonym: "factor XIIIa" RELATED [EC:2.3.2.13] synonym: "fibrin stabilizing factor" RELATED [EC:2.3.2.13] synonym: "fibrinoligase activity" EXACT [] synonym: "glutaminylpeptide gamma-glutamyltransferase activity" EXACT [EC:2.3.2.13] synonym: "polyamine transglutaminase activity" RELATED [EC:2.3.2.13] synonym: "protein-glutamine:amine gamma-glutamyltransferase" EXACT [EC:2.3.2.13] synonym: "R-glutaminyl-peptide:amine gamma-glutamyl transferase activity" EXACT [EC:2.3.2.13] synonym: "TGase activity" EXACT [] synonym: "tissue transglutaminase" NARROW [EC:2.3.2.13] synonym: "transglutaminase activity" EXACT [] xref: EC:2.3.2.13 xref: MetaCyc:2.3.2.13-RXN xref: Reactome:11549 "protein-glutamine gamma-glutamyltransferase activity" xref: RESID:AA0124 is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003811 name: complement activity namespace: molecular_function def: "OBSOLETE. Any of a set of activities involved in the complement cascade." [GOC:jl] comment: This term was made obsolete because it refers to involvement in a biological process. is_obsolete: true consider: GO:0006956 [Term] id: GO:0003812 name: alternative-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Arg-Ser bond in complement component C3 alpha-chain to yield C3a and C3b, and Arg bond in complement component C5 alpha-chain to yield C5a and C5b." [EC:3.4.21.47] comment: This term was made obsolete because it represents a gene product. synonym: "(C3b)n,Bb" RELATED [EC:3.4.21.47] synonym: "(CVF)-dependent glycine-rich-beta-glucoprotein" RELATED [EC:3.4.21.47] synonym: "alternative complement pathway C3(C5) convertase activity" EXACT [EC:3.4.21.47] synonym: "C3 convertase activity" BROAD [EC:3.4.21.47] synonym: "C3 proactivator" RELATED [EC:3.4.21.47] synonym: "C3b,Bb,CVF,Bb,C5 convertase activity" EXACT [EC:3.4.21.47] synonym: "C5 convertase activity" BROAD [EC:3.4.21.47] synonym: "cobra venom factor-dependent C3 convertase" NARROW [EC:3.4.21.47] synonym: "complement C 3(C 5) convertase (amplification)" EXACT [EC:3.4.21.47] synonym: "complement component C3/C5 convertase (alternative) activity" EXACT [EC:3.4.21.47] synonym: "complement factor B activity" EXACT [EC:3.4.21.47] synonym: "CVF,Bb" RELATED [EC:3.4.21.47] synonym: "glycine-rich beta-glycoprotein" RELATED [EC:3.4.21.47] synonym: "heat-labile factor" RELATED [EC:3.4.21.47] synonym: "proenzyme factor B" EXACT [] synonym: "properdin factor B activity" EXACT [EC:3.4.21.47] xref: EC:3.4.21.47 xref: MetaCyc:3.4.21.47-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003813 name: classical-complement-pathway C3/C5 convertase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Arg-Ser bond in complement component C3 alpha-chain to form C3a and C3b, and Arg bond in complement component C5 alpha-chain to form C5a and C5b." [EC:3.4.21.43] comment: This term was made obsolete because it represents a gene product. synonym: "C3 convertase activity" BROAD [EC:3.4.21.43] synonym: "C42" RELATED [EC:3.4.21.43] synonym: "C423" RELATED [EC:3.4.21.43] synonym: "C4b,2a" RELATED [EC:3.4.21.43] synonym: "C4b,2a,3b" RELATED [EC:3.4.21.43] synonym: "C5 convertase activity" BROAD [EC:3.4.21.43] synonym: "complement C2 activity" BROAD [EC:3.4.21.43] synonym: "complement C3 convertase activity" EXACT [EC:3.4.21.43] synonym: "complement C42" RELATED [EC:3.4.21.43] xref: EC:3.4.21.43 xref: MetaCyc:3.4.21.43-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003815 name: complement component C1r activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys(or Arg)-Ile bond in complement subcomponent C1s to form the active form of C1s (EC:3.4.21.42)." [EC:3.4.21.41] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1r" RELATED [EC:3.4.21.41] synonym: "C1r esterase activity" EXACT [EC:3.4.21.41] synonym: "complement subcomponent C1r" RELATED [EC:3.4.21.41] xref: EC:3.4.21.41 xref: MetaCyc:3.4.21.41-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003816 name: complement component C1s activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component C4 to C4a and C4b (Arg-Ala bond), and component C2 to C2a and C2b (Lys-Lys or Arg-Lys bond)." [EC:3.4.21.42] comment: This term was made obsolete because it represents a gene product. synonym: "activated complement C1s" RELATED [EC:3.4.21.42] synonym: "C1 esterase activity" EXACT [EC:3.4.21.42] synonym: "C1s esterase activity" EXACT [EC:3.4.21.42] synonym: "complement C1s" RELATED [EC:3.4.21.42] synonym: "complement subcomponent C1s" RELATED [EC:3.4.21.42] xref: EC:3.4.21.42 xref: MetaCyc:3.4.21.42-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003817 name: complement factor D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of component factor B (Arg-Lys) when in complex with C3b or with cobra venom factor (CVF)." [EC:3.4.21.46] comment: This term was made obsolete because it represents a gene product. synonym: "adipsin" EXACT [] synonym: "C3 convertase activator activity" EXACT [EC:3.4.21.46] synonym: "C3 proactivator convertase activity" EXACT [EC:3.4.21.46] synonym: "factor D" RELATED [EC:3.4.21.46] synonym: "factor D (complement)" RELATED [EC:3.4.21.46] synonym: "properdin factor D esterase activity" EXACT [EC:3.4.21.46] xref: EC:3.4.21.46 xref: MetaCyc:3.4.21.46-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003818 name: complement factor I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of complement subcomponents C3b, iC3b and C4b by proteolytic cleavage." [EC:3.4.21.45] comment: This term was made obsolete because it represents a gene product. synonym: "C3b inactivator activity" NARROW [EC:3.4.21.45] synonym: "C3b/C4b inactivator activity" EXACT [EC:3.4.21.45] synonym: "C3bINA" RELATED [EC:3.4.21.45] synonym: "complement C3b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C3b/C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4b inactivator" RELATED [EC:3.4.21.45] synonym: "complement C4bi" RELATED [EC:3.4.21.45] synonym: "complement component C3b inactivator activity" EXACT [EC:3.4.21.45] synonym: "conglutinogen-activating factor C" RELATED [EC:3.4.21.45] synonym: "factor I" RELATED [EC:3.4.21.45] xref: EC:3.4.21.45 xref: MetaCyc:3.4.21.45-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0003819 name: major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "MHC protein" EXACT [] is_obsolete: true [Term] id: GO:0003820 name: class I major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042612 [Term] id: GO:0003821 name: class II major histocompatibility complex antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true consider: GO:0042613 [Term] id: GO:0003822 name: MHC-interacting protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0003823 name: antigen binding namespace: molecular_function def: "Interacting selectively and non-covalently with an antigen, any substance which is capable of inducing a specific immune response and of reacting with the products of that response, the specific antibody or specifically sensitized T-lymphocytes, or both. Binding may counteract the biological activity of the antigen." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir synonym: "antibody" RELATED [] synonym: "B cell receptor activity" RELATED [] synonym: "immunoglobulin" RELATED [] synonym: "opsonin activity" RELATED [] is_a: GO:0005488 ! binding [Term] id: GO:0003824 name: catalytic activity namespace: molecular_function def: "Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "enzyme activity" EXACT [GOC:dph, GOC:tb] xref: Wikipedia:Enzyme is_a: GO:0003674 ! molecular_function relationship: part_of GO:0008152 ! metabolic process [Term] id: GO:0003825 name: alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + D-glucose 6-phosphate = UDP + alpha,alpha-trehalose 6-phosphate." [EC:2.4.1.15] subset: gosubset_prok synonym: "alpha,alpha-trehalose phosphate synthase (UDP-forming)" EXACT [EC:2.4.1.15] synonym: "phosphotrehalose-uridine diphosphate transglucosylase activity" EXACT [EC:2.4.1.15] synonym: "transglucosylase activity" EXACT [] synonym: "trehalose 6-phosphate synthase activity" EXACT [] synonym: "trehalose 6-phosphate synthetase activity" EXACT [] synonym: "trehalose phosphate synthase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose phosphate-uridine diphosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-P synthetase activity" EXACT [EC:2.4.1.15] synonym: "trehalose-phosphate synthase activity" EXACT [] synonym: "trehalose-phosphate synthetase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyl transferase activity" EXACT [] synonym: "trehalosephosphate-UDP glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucose-phosphate glucosyltransferase activity" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [] synonym: "UDPglucose-glucose-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "UDPglucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.15] synonym: "uridine diphosphoglucose phosphate glucosyltransferase activity" EXACT [EC:2.4.1.15] xref: EC:2.4.1.15 xref: MetaCyc:TREHALOSE6PSYN-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003826 name: alpha-ketoacid dehydrogenase activity namespace: molecular_function def: "Catalysis of an oxidation-reduction (redox) reaction involving an alpha-ketoacid." [GOC:mah] subset: gosubset_prok xref: Reactome:11574 "alpha-ketoacid dehydrogenase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0003827 name: alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2 = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3-(R1)-beta-D-mannosyl-R2." [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTI" RELATED [EC:2.4.1.101] synonym: "GNTI activity" EXACT [EC:2.4.1.101] synonym: "N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetyl-D-glucosamine:3-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-1,3-D-mannoside-beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "UDP-N-acetylglucosaminyl:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.101] synonym: "uridine diphosphoacetylglucosamine-alpha-1,3-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.101] xref: EC:2.4.1.101 xref: MetaCyc:2.4.1.101-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003828 name: alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R = CMP + alpha-N-acetylneuraminyl-2,8-alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-R." [EC:2.4.99.8] synonym: "alpha-2,8-sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "alpha-N-acetylneuraminide alpha-2,8-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate:alpha-N-acetylneuraminyl-2,3-beta-D-galactoside alpha-2,8-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.8] synonym: "CMP-NeuAc:LM1(alpha2-8) sialyltranferase activity" EXACT [EC:2.4.99.8] synonym: "cytidine monophosphoacetylneuraminate-ganglioside GM3" RELATED [EC:2.4.99.8] synonym: "ganglioside GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "ganglioside GD3 synthetase sialyltransferase activity" EXACT [EC:2.4.99.8] synonym: "GD3 synthase activity" EXACT [EC:2.4.99.8] synonym: "SAT-2" RELATED [EC:2.4.99.8] xref: EC:2.4.99.8 xref: MetaCyc:2.4.99.8-RXN xref: Reactome:11580 "alpha-N-acetylneuraminate alpha-2,8-sialyltransferase activity" is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003829 name: beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R = UDP + beta-D-galactosyl-1,3-(N-acetyl-beta-D-glucosaminyl-1,6)-N-acetyl-D-galactosaminyl-R." [EC:2.4.1.102] synonym: "beta(6)-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "beta6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 2 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "core 6-beta-GlcNAc-transferase A" RELATED [EC:2.4.1.102] synonym: "O-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I activity" EXACT [EC:2.4.1.102] synonym: "UDP-N-acetyl-D-glucosamine:O-glycosyl-glycoprotein (N-acetyl-D-glucosamine to N-acetyl-D-galactosamine of beta-D-galactosyl-1,3-N-acetyl-D-galactosaminyl-R) beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.102] synonym: "uridine diphosphoacetylglucosamine-mucin beta-(1->6)-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.102] xref: EC:2.4.1.102 xref: MetaCyc:2.4.1.102-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003830 name: beta-1,4-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-mannosyl-R = UDP + 4-(N-acetyl-beta-D-glucosaminyl)-beta-D-mannosyl-R." [EC:2.4.1.144] subset: gosubset_prok synonym: "beta-1,4-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "beta-1,4-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "GnTIII activity" EXACT [EC:2.4.1.144] synonym: "N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-mannosyl-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase III activity" EXACT [EC:2.4.1.144] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase III" RELATED [EC:2.4.1.144] xref: EC:2.4.1.144 xref: MetaCyc:2.4.1.144-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0003831 name: beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-beta-D-glucosaminylglycopeptide = UDP + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminylglycopeptide." [EC:2.4.1.38] synonym: "beta-N-acetyl-beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "GalT activity" RELATED [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyl-transferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein 4-beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "glycoprotein beta-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "thyroid galactosyltransferase activity" NARROW [EC:2.4.1.38] synonym: "thyroid glycoprotein beta-galactosyltransferase" NARROW [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of 4-N-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-D-xylose:glycoprotein (D-xylose to the 3,6-disubstituted mannose of N4-{N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->3)-[N-acetyl-beta-D-glucosaminyl-(1->2)-alpha-D-mannosyl-(1->6)]-beta-D-mannosyl-(1->4)-N-acetyl-beta-D-glucosaminyl-(1->4)-N-acetyl-beta-D-glucosaminyl}asparagine) 2-beta-D-xylosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose--glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDP-galactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "UDPgalactose:N-acetyl-beta-D-glucosaminylglycopeptide beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.38] synonym: "uridine diphosphogalactose-glycoprotein galactosyltransferase activity" EXACT [EC:2.4.1.38] xref: EC:2.4.1.38 xref: MetaCyc:2.4.1.38-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003832 name: beta-alanyl-dopamine hydrolase activity namespace: molecular_function def: "Catalysis of the conversion of beta-alanyl dopamine to dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl-dopamine hydrolase activity" EXACT [] synonym: "NBAD hydrolase activity" EXACT [] is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003833 name: beta-alanyl-dopamine synthase activity namespace: molecular_function def: "Catalysis of the synthesis of beta-alanyl-dopamine from the precursor dopamine (3,4-dihydroxyphenylethylamine)." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:12957543] synonym: "N-beta-alanyl dopamine synthetase activity" EXACT [] synonym: "NBAD transferase activity" EXACT [] is_a: GO:0016874 ! ligase activity [Term] id: GO:0003834 name: beta-carotene 15,15'-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: beta-carotene + O2 = 2 retinal." [EC:1.14.99.36] comment: Note that this function was formerly EC:1.13.11.21. synonym: "beta-carotene 15,15'-dioxygenase activity" EXACT [] synonym: "beta-carotene:oxygen 15,15'-oxidoreductase (bond-cleaving)" EXACT [EC:1.14.99.36] synonym: "carotene 15,15'-dioxygenase activity" EXACT [EC:1.14.99.36] synonym: "carotene dioxygenase activity" EXACT [EC:1.14.99.36] xref: EC:1.14.99.36 xref: MetaCyc:BETA-CAROTENE-1515-DIOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003835 name: beta-galactoside alpha-2,6-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-acetyl-beta-D-glucosamine = CMP + alpha-N-acetylneuraminyl-2,6-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine." [EC:2.4.99.1] synonym: "beta-galactosamide alpha-2,6-sialyltransferase activity" EXACT [] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,6-sialyltransferase activity" EXACT [EC:2.4.99.1] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosamine alpha-2,6-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.1] xref: EC:2.4.99.1 xref: MetaCyc:2.4.99.1-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003836 name: beta-galactoside alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,3-N-acetyl-alpha-D-galactosaminyl-R." [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.4] synonym: "CMP-N-acetylneuraminate:beta-D-galactoside alpha-2,3-N-acetylneuraminyl-transferase activity" EXACT [EC:2.4.99.4] xref: EC:2.4.99.4 xref: MetaCyc:2.4.99.4-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0003837 name: beta-ureidopropionase activity namespace: molecular_function def: "Catalysis of the reaction: N-carbamoyl-beta-alanine + H2O = beta-alanine + CO2 + NH3." [EC:3.5.1.6] subset: gosubset_prok synonym: "N-carbamoyl-beta-alanine amidohydrolase activity" EXACT [EC:3.5.1.6] xref: EC:3.5.1.6 xref: MetaCyc:BETA-UREIDOPROPIONASE-RXN xref: Reactome:11609 "beta-ureidopropionase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0003838 name: sterol 24-C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 5-alpha-cholest-8,24-dien-3-beta-ol = S-adenosyl-L-homocysteine + 24-methylene-5-alpha-cholest-8-en-3-beta-ol." [EC:2.1.1.41] subset: gosubset_prok synonym: "24-sterol C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta(24)-sterol C-methyltransferase activity" EXACT [] synonym: "delta(24)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "delta24-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "phytosterol methyltransferase activity" NARROW [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol Delta(24)-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-4-methionine:sterol delta24-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta(24(23))-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:Delta24(23)-sterol methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "S-adenosyl-L-methionine:zymosterol 24-C-methyltransferase activity" EXACT [EC:2.1.1.41] synonym: "SMT1 activity" NARROW [EC:2.1.1.41] synonym: "zymosterol-24-methyltransferase activity" NARROW [EC:2.1.1.41] xref: EC:2.1.1.41 xref: MetaCyc:RXN3O-178 is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0003839 name: gamma-glutamylcyclotransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-L-amino acid = 5-oxoproline + L-amino acid." [EC:2.3.2.4] synonym: "(5-L-glutamyl)-L-amino-acid 5-glutamyltransferase (cyclizing)" EXACT [EC:2.3.2.4] synonym: "gamma-glutamyl-amino acid cyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "gamma-L-glutamylcyclotransferase activity" EXACT [EC:2.3.2.4] synonym: "L-glutamic cyclase activity" EXACT [EC:2.3.2.4] xref: EC:2.3.2.4 xref: MetaCyc:GAMMA-GLUTAMYLCYCLOTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003840 name: gamma-glutamyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (5-L-glutamyl)-peptide + an amino acid = peptide + 5-L-glutamyl-amino acid." [EC:2.3.2.2] subset: gosubset_prok synonym: "(5-L-glutamyl)-peptide:amino-acid 5-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "alpha-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl peptidyltransferase activity" EXACT [EC:2.3.2.2] synonym: "gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "gamma-GPT" RELATED [EC:2.3.2.2] synonym: "gamma-GT" RELATED [EC:2.3.2.2] synonym: "gamma-GTP" RELATED [EC:2.3.2.2] synonym: "glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyl transpeptidase activity" EXACT [EC:2.3.2.2] synonym: "L-gamma-glutamyltransferase activity" EXACT [EC:2.3.2.2] synonym: "L-glutamyltransferase activity" EXACT [EC:2.3.2.2] xref: EC:2.3.2.2 xref: MetaCyc:GAMMA-GLUTAMYLTRANSFERASE-RXN xref: Reactome:11628 "gamma-glutamyltransferase activity" is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0003841 name: 1-acylglycerol-3-phosphate O-acyltransferase activity namespace: molecular_function alt_id: GO:0004469 def: "Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol 3-phosphate = CoA + 1,2-diacyl-sn-glycerol 3-phosphate." [EC:2.3.1.51] subset: gosubset_prok synonym: "1-acyl-sn-glycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acyl-sn-glycerol-3-phosphate acyltransferase activity" EXACT [] synonym: "1-acylglycero-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerolphosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "1-acylglycerophosphate acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "acyl-CoA:1-acyl-sn-glycerol-3-phosphate 2-O-acyltransferase activity" EXACT [EC:2.3.1.51] synonym: "lysophosphatidate acyltransferase activity" EXACT [] synonym: "lysophosphatidic acid-acyltransferase activity" EXACT [EC:2.3.1.51] xref: EC:2.3.1.51 xref: MetaCyc:RXN-1623 is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003842 name: 1-pyrroline-5-carboxylate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-pyrroline-5-carboxylate + NAD+ + H2O = L-glutamate + NADH + H+." [EC:1.5.1.12] subset: gosubset_prok synonym: "1-pyrroline dehydrogenase" BROAD [EC:1.5.1.12] synonym: "1-pyrroline-5-carboxylate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "delta1-pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "L-pyrroline-5-carboxylate-NAD+ oxidoreductase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylate dehydrogenase activity" EXACT [EC:1.5.1.12] synonym: "pyrroline-5-carboxylic acid dehydrogenase activity" EXACT [EC:1.5.1.12] xref: EC:1.5.1.12 xref: MetaCyc:PYRROLINECARBDEHYDROG-RXN xref: Reactome:11630 "1-pyrroline-5-carboxylate dehydrogenase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0003843 name: 1,3-beta-glucan synthase activity namespace: molecular_function alt_id: GO:0009981 def: "Catalysis of the reaction: UDP-glucose + 1,3-beta-D-glucosyl(n) = UDP + 1,3-beta-D-glucosyl(n+1)." [EC:2.4.1.34] synonym: "(1,3)-beta-glucan (callose) synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-D-glucan-UDP glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "1,3-beta-glucan-uridine diphosphoglucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "beta-1,3-glucan synthase activity" EXACT [] synonym: "beta-1,3-glucan synthetase activity" EXACT [EC:2.4.1.34] synonym: "callose synthase activity" EXACT [] synonym: "callose synthetase activity" EXACT [EC:2.4.1.34] synonym: "GS-II" RELATED [EC:2.4.1.34] synonym: "paramylon synthetase" RELATED [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:(1,3)beta-glucan synthase activity" EXACT [EC:2.4.1.34] synonym: "UDP-glucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose-1,3-beta-D-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "UDPglucose:1,3-beta-D-glucan 3-beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.34] synonym: "uridine diphosphoglucose-1,3-beta-glucan glucosyltransferase activity" EXACT [EC:2.4.1.34] xref: EC:2.4.1.34 xref: MetaCyc:13-BETA-GLUCAN-SYNTHASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003844 name: 1,4-alpha-glucan branching enzyme activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a 1,4-alpha-D-glucan chain to a primary hydroxyl group in a similar glucan chain." [EC:2.4.1.18] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 6-alpha-D-(1,4-alpha-D-glucano)-transferase activity" EXACT [] synonym: "1,4-glucan-6-(1,4-glucano)-transferase activity" EXACT [] synonym: "alpha-1,4-glucan:alpha-1,4-glucan-6-glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "alpha-glucan-branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4 to 1,6)transglucosidase activity" EXACT [EC:2.4.1.18] synonym: "amylo-(1,4->1,6)-transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "amylose isomerase activity" EXACT [EC:2.4.1.18] synonym: "branching enzyme activity" RELATED [EC:2.4.1.18] synonym: "branching glycosyltransferase activity" EXACT [EC:2.4.1.18] synonym: "enzymatic branching factor" RELATED [EC:2.4.1.18] synonym: "enzyme Q" RELATED [EC:2.4.1.18] synonym: "glucosan transglycosylase activity" EXACT [EC:2.4.1.18] synonym: "glycogen branching enzyme activity" EXACT [EC:2.4.1.18] synonym: "plant branching enzyme" RELATED [EC:2.4.1.18] synonym: "Q-enzyme" RELATED [EC:2.4.1.18] synonym: "starch branching enzyme" RELATED [EC:2.4.1.18] xref: EC:2.4.1.18 xref: MetaCyc:GLYCOGEN-BRANCH-RXN xref: Reactome:11632 "1,4-alpha-glucan branching enzyme activity" is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0003845 name: 11-beta-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: an 11-beta-hydroxysteroid + NAD(P)+ = an 11-oxosteroid + NAD(P)H + H+." [EC:1.1.1.146, PMID:15761036] subset: gosubset_prok synonym: "11beta-hydroxy steroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "11beta-hydroxysteroid dehydrogenase" EXACT [EC:1.1.1.146] synonym: "beta-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.146] synonym: "corticosteroid 11-reductase" RELATED [EC:1.1.1.146] synonym: "corticosteroid 11beta-dehydrogenase" RELATED [EC:1.1.1.146] synonym: "dehydrogenase, 11beta-hydroxy steroid" EXACT [EC:1.1.1.146] xref: MetaCyc:11-BETA-HYDROXYSTEROID-DEHYDROGENASE-RXN xref: Reactome:11633 "11-beta-hydroxysteroid dehydrogenase activity" xref: Wikipedia:11beta-hydroxysteroid_dehydrogenase is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003846 name: 2-acylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 2-acylglycerol = CoA + diacylglycerol." [EC:2.3.1.22] synonym: "acyl coenzyme A-monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acyl-CoA:2-acylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "acylglycerol palmitoyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoacylglycerol acyltransferase activity" EXACT [EC:2.3.1.22] synonym: "monoglyceride acyltransferase activity" EXACT [EC:2.3.1.22] xref: EC:2.3.1.22 xref: MetaCyc:2-ACYLGLYCEROL-O-ACYLTRANSFERASE-RXN is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0003847 name: 1-alkyl-2-acetylglycerophosphocholine esterase activity namespace: molecular_function def: "Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycero-3-phosphocholine + H2O = 1-alkyl-sn-glycero-3-phosphocholine + acetate." [EC:3.1.1.47] subset: gosubset_prok synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetohydrolase activity" EXACT [EC:3.1.1.47] synonym: "1-alkyl-2-acetyl-sn-glycero-3-phosphocholine acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "2-acetyl-1-alkylglycerophosphocholine esterase activity" EXACT [] synonym: "alkylacetyl-GPC:acetylhydrolase activity" EXACT [EC:3.1.1.47] synonym: "LDL-associated phospholipase A(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-associated phospholipase A2" RELATED [EC:3.1.1.47] synonym: "LDL-PLA(2) activity" RELATED [EC:3.1.1.47] synonym: "LDL-PLA2" RELATED [EC:3.1.1.47] synonym: "PAF 2-acylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "PAF acetylhydrolase activity" RELATED [EC:3.1.1.47] synonym: "platelet-activating factor acetylhydrolase activity" RELATED [EC:3.1.1.47] xref: EC:3.1.1.47 xref: MetaCyc:3.1.1.47-RXN is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0003848 name: 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine = AMP + 2-amino-7,8-dihydro-4-hydroxy-6-(diphosphooxymethyl)pteridine." [EC:2.7.6.3] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [] synonym: "6-hydroxymethyl-7,8-dihydropterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin diphosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydro-6-hydroxymethylpterin pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "7,8-dihydroxymethylpterin-pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "ATP:2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine 6'-diphosphotransferase activity" EXACT [EC:2.7.6.3] synonym: "H2-pteridine-CH2OH pyrophosphokinase activity" EXACT [EC:2.7.6.3] synonym: "HPPK" RELATED [EC:2.7.6.3] synonym: "hydroxymethyldihydropteridine pyrophosphokinase activity" EXACT [EC:2.7.6.3] xref: EC:2.7.6.3 xref: MetaCyc:H2PTERIDINEPYROPHOSPHOKIN-RXN is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0003849 name: 3-deoxy-7-phosphoheptulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + D-erythrose 4-phosphate + H2O = 2-dehydro-3-deoxy-D-arabino-heptonate 7-phosphate + phosphate." [EC:2.5.1.54] comment: Note that this function was formerly EC:4.1.2.15. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-phosphoheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "2-dehydro-3-deoxyphosphoheptonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-D-arabino-heptonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-2-heptulosonic acid 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptolosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "3-deoxy-D-arabino-heptulosonate 7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate" RELATED [EC:2.5.1.54] synonym: "7-phospho-2-dehydro-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "7-phospho-2-keto-3-deoxy-D-arabino-heptonate D-erythrose-4-phosphate lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.54] synonym: "D-erythrose-4-phosphate-lyase activity" RELATED [EC:2.5.1.54] synonym: "DAH7-P synthase activity" EXACT [EC:2.5.1.54] synonym: "DAHP synthase activity" EXACT [EC:2.5.1.54] synonym: "deoxy-D-arabino-heptulosonate-7-phosphate synthetase activity" EXACT [EC:2.5.1.54] synonym: "DHAP synthase activity" EXACT [EC:2.5.1.54] synonym: "DS-Co activity" RELATED [EC:2.5.1.54] synonym: "DS-Mn activity" RELATED [EC:2.5.1.54] synonym: "KDPH synthase activity" EXACT [EC:2.5.1.54] synonym: "KDPH synthetase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-dehydro-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptanoate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-keto-3-deoxyheptonic aldolase activity" EXACT [EC:2.5.1.54] synonym: "phospho-2-oxo-3-deoxyheptonate aldolase activity" EXACT [EC:2.5.1.54] synonym: "phosphoenolpyruvate:D-erythrose-4-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.54] xref: EC:2.5.1.54 xref: MetaCyc:DAHPSYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003850 name: 2-deoxyglucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-glucose 6-phosphate + H2O = 2-deoxy-D-glucose + phosphate." [EC:3.1.3.68] synonym: "2-deoxy-D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.68] synonym: "2-deoxyglucose-6-phosphate phosphatase activity" EXACT [EC:3.1.3.68] xref: EC:3.1.3.68 xref: MetaCyc:3.1.3.68-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0003851 name: 2-hydroxyacylsphingosine 1-beta-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + 2-(2-hydroxyacyl)sphingosine = UDP + 1-(beta-D-galactosyl)-2-(2-hydroxyacyl)sphingosine." [EC:2.4.1.45] synonym: "cerebroside synthase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose-ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDP-galactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-(2-hydroxyacyl)sphingosine 1-beta-D-galactosyl-transferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:2-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "UDPgalactose:ceramide galactosyltransferase activity" EXACT [EC:2.4.1.45] synonym: "uridine diphosphogalactose-2-hydroxyacylsphingosine galactosyltransferase activity" EXACT [EC:2.4.1.45] xref: EC:2.4.1.45 xref: MetaCyc:2.4.1.45-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003852 name: 2-isopropylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + 3-methyl-2-oxobutanoate + H2O = (2S)-2-isopropylmalate + CoA." [EC:2.3.3.13] comment: Note that this function was formerly EC:4.1.3.12. subset: gosubset_prok synonym: "3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.13] synonym: "acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.13] synonym: "alpha-IPM synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] synonym: "alpha-isopropylmalic synthetase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthase activity" EXACT [EC:2.3.3.13] synonym: "isopropylmalate synthetase activity" EXACT [EC:2.3.3.13] xref: EC:2.3.3.13 xref: MetaCyc:2-ISOPROPYLMALATESYN-RXN is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003853 name: 2-methylacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methylbutanoyl-CoA + acceptor = 2-methylbut-2-enoyl-CoA + reduced acceptor." [EC:1.3.99.12] synonym: "2-methyl branched chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "2-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.12] synonym: "branched-chain acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.12] xref: EC:1.3.99.12 xref: MetaCyc:2-METHYLACYL-COA-DEHYDROGENASE-RXN is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0003854 name: 3-beta-hydroxy-delta5-steroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxy-delta(5)-steroid + NAD+ = 3-oxo-delta(5)-steroid + NADH + H+." [EC:1.1.1.145] subset: gosubset_prok synonym: "3-beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3-beta-hydroxy-D5-steroid dehydrogenase activity" EXACT [] synonym: "3beta-HSDH" RELATED [EC:1.1.1.145] synonym: "3beta-hydroxy steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-5-ene-steroid oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-C27-steroid oxidoreductase" BROAD [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.145] synonym: "5-ene-3-beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "delta5-3beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.145] synonym: "progesterone reductase activity" BROAD [EC:1.1.1.145] synonym: "steroid-delta5-3beta-ol dehydrogenase activity" EXACT [EC:1.1.1.145] xref: EC:1.1.1.145 xref: MetaCyc:1.1.1.145-RXN xref: Reactome:11642 "3-beta-hydroxy-delta5-steroid dehydrogenase activity" is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003855 name: 3-dehydroquinate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O." [EC:4.2.1.10] subset: gosubset_prok synonym: "3-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase (3-dehydroshikimate-forming)" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "3-dehydroquinate hydrolase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "5-dehydroquinate hydro-lyase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinase activity" EXACT [EC:4.2.1.10] synonym: "dehydroquinate dehydratase activity" EXACT [EC:4.2.1.10] synonym: "DHQase" EXACT [EC:4.2.1.10] xref: EC:4.2.1.10 xref: MetaCyc:3-DEHYDROQUINATE-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003856 name: 3-dehydroquinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 3-deoxy-arabino-heptulosonate 7-phosphate = 3-dehydroquinate + phosphate." [EC:4.2.3.4] subset: gosubset_prok synonym: "3-dehydroquinate synthetase activity" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulonate-7-phosphate phosphate-lyase (cyclizing; 3-dehydroquinate-forming)" EXACT [EC:4.2.3.4] synonym: "3-deoxy-arabino-heptulosonate-7-phosphate phosphate-lyase (cyclizing)" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "5-dehydroquinic acid synthetase activity" EXACT [EC:4.2.3.4] synonym: "dehydroquinate synthase activity" EXACT [EC:4.2.3.4] synonym: "DHQ synthase" EXACT [PMID:17586643] synonym: "DHQS" EXACT [PMID:17586643] xref: EC:4.2.3.4 xref: MetaCyc:3-DEHYDROQUINATE-SYNTHASE-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003857 name: 3-hydroxyacyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxyacyl-CoA + NAD+ = 3-oxoacyl-CoA + NADH + H+." [EC:1.1.1.35] comment: See also 'long-chain-3-hydroxyacyl-CoA dehydrogenase activity ; GO:0016509'. subset: gosubset_prok synonym: "beta-hydroxyacyl dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacyl-coenzyme A synthetase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxyacylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-hydroxybutyrylcoenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "beta-keto-reductase activity" EXACT [EC:1.1.1.35] synonym: "beta-ketoacyl-CoA reductase" BROAD [EC:1.1.1.35] synonym: "L-3-hydroxyacyl CoA dehydrogenase activity" EXACT [EC:1.1.1.35] synonym: "L-3-hydroxyacyl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.35] xref: EC:1.1.1.35 xref: MetaCyc:OHACYL-COA-DEHYDROG-RXN xref: Reactome:11645 "3-hydroxyacyl-CoA dehydrogenase activity" xref: UM-BBD_enzymeID:e0664 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003858 name: 3-hydroxybutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + NADH + H+." [EC:1.1.1.30] subset: gosubset_prok synonym: "D-beta-hydroxybutyrate dehydrogenase activity" EXACT [EC:1.1.1.30] xref: EC:1.1.1.30 xref: MetaCyc:3-HYDROXYBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:11646 "3-hydroxybutyrate dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003859 name: 3-hydroxybutyryl-CoA dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxybutanoyl-CoA = crotonoyl-CoA + H2O." [EC:4.2.1.55] subset: gosubset_prok synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase (crotonoyl-CoA-forming)" EXACT [EC:4.2.1.55] synonym: "(3R)-3-hydroxybutanoyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.55] synonym: "crotonase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl coenzyme A dehydratase activity" EXACT [EC:4.2.1.55] synonym: "D-3-hydroxybutyryl-CoA dehydratase activity" EXACT [EC:4.2.1.55] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.55] xref: EC:4.2.1.55 xref: MetaCyc:3-HYDROXBUTYRYL-COA-DEHYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003860 name: 3-hydroxyisobutyryl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoyl-CoA + H2O = CoA + 3-hydroxy-2-methylpropanoate." [EC:3.1.2.4] subset: gosubset_prok synonym: "3-hydroxy-2-methylpropanoyl-CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "3-hydroxy-isobutyryl CoA hydrolase activity" EXACT [EC:3.1.2.4] synonym: "HIB CoA deacylase activity" EXACT [EC:3.1.2.4] xref: EC:3.1.2.4 xref: MetaCyc:3-HYDROXYISOBUTYRYL-COA-HYDROLASE-RXN xref: Reactome:11660 "3-hydroxyisobutyryl-CoA hydrolase activity" is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003861 name: 3-isopropylmalate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 3-isopropylmalate = 2-isopropylmaleate + H2O." [EC:4.2.1.33] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate hydro-lyase (2-isopropylmaleate-forming)" EXACT [EC:4.2.1.33] synonym: "(2R,3S)-3-isopropylmalate hydro-lyase activity" EXACT [EC:4.2.1.33] synonym: "alpha-IPM isomerase activity" EXACT [EC:4.2.1.33] synonym: "alpha-isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] synonym: "beta-isopropylmalate dehydratase activity" EXACT [EC:4.2.1.33] synonym: "isopropylmalate isomerase activity" EXACT [EC:4.2.1.33] xref: EC:4.2.1.33 xref: MetaCyc:3-ISOPROPYLMALISOM-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003862 name: 3-isopropylmalate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-carboxy-2-hydroxy-4-methylpentanoate + NAD+ = 3-carboxy-4-methyl-2-oxopentanoate + NADH + H+." [EC:1.1.1.85] subset: gosubset_prok synonym: "(2R,3S)-3-isopropylmalate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "3-carboxy-2-hydroxy-4-methylpentanoate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.85] synonym: "beta-IPM dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] synonym: "beta-isopropylmalic enzyme" RELATED [EC:1.1.1.85] synonym: "IMDH activity" EXACT [EC:1.1.1.85] synonym: "IPMDH" RELATED [EC:1.1.1.85] synonym: "threo-Ds-3-isopropylmalate dehydrogenase activity" EXACT [EC:1.1.1.85] xref: EC:1.1.1.85 xref: MetaCyc:3-ISOPROPYLMALDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003863 name: 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 3-methyl-2-oxobutanoate + lipoamide = S-(2-methylpropanoyl)dihydrolipoamide + CO2." [EC:1.2.4.4] subset: gosubset_prok synonym: "2-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "2-oxoisovalerate (lipoate) dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate dehydrogenase (lipoamide) activity" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:dihydrolipoyllysine-residue (2-methylpropanoyl)transferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-2-methylpropanoylating)" EXACT [EC:1.2.4.4] synonym: "3-methyl-2-oxobutanoate:lipoamide oxidoreductase (decarboxylating and acceptor-2-methylpropanoylating) activity" EXACT [EC:1.2.4.4] synonym: "alpha-keto-alpha-methylvalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisocaproic-alpha-keto-alpha-methylvaleric dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-ketoisovalerate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "alpha-oxoisocaproate dehydrogenase activity" EXACT [EC:1.2.4.4] synonym: "BCKDH activity" RELATED [EC:1.2.4.4] synonym: "BCOAD activity" RELATED [EC:1.2.4.4] synonym: "branched chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain (-2-oxoacid) dehydrogenase (BCD) activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain 2-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain alpha-oxo acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain keto acid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "branched-chain ketoacid dehydrogenase activity" RELATED [EC:1.2.4.4] synonym: "dehydrogenase, 2-oxoisovalerate (lipoate) activity" EXACT [EC:1.2.4.4] synonym: "dehydrogenase, branched chain alpha-keto acid activity" RELATED [EC:1.2.4.4] xref: EC:1.2.4.4 xref: MetaCyc:1.2.4.4-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0003864 name: 3-methyl-2-oxobutanoate hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + 3-methyl-2-oxobutanoate = tetrahydrofolate + 2-dehydropantoate." [EC:2.1.2.11] subset: gosubset_prok synonym: "5,10-methylene tetrahydrofolate:alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "5,10-methylenetetrahydrofolate:3-methyl-2-oxobutanoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "alpha-ketoisovalerate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "dehydropantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "ketopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] synonym: "oxopantoate hydroxymethyltransferase activity" EXACT [EC:2.1.2.11] xref: EC:2.1.2.11 xref: MetaCyc:3-CH3-2-OXOBUTANOATE-OH-CH3-XFER-RXN is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0003865 name: 3-oxo-5-alpha-steroid 4-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-5-alpha-steroid + acceptor = a 3-oxo-delta(4)-steroid + reduced acceptor." [EC:1.3.99.5] synonym: "3-keto-delta4-steroid-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid 4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid delta4-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:(acceptor) delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxo-5alpha-steroid:acceptor delta4-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "3-oxosteroid delta4-dehydrogenase" BROAD [EC:1.3.99.5] synonym: "4-ene-3-ketosteroid-5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-3-keto steroid 5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-ketosteroid5alpha-oxidoreductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxo steroid reductase activity" EXACT [EC:1.3.99.5] synonym: "delta4-3-oxosteroid-5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "delta4-5alpha-dehydrogenase activity" EXACT [EC:1.3.99.5] synonym: "steroid 5 alpha reductase" BROAD [EC:1.3.99.5] synonym: "steroid 5-alpha-reductase activity" BROAD [EC:1.3.99.5] synonym: "steroid 5alpha-reductase" BROAD [EC:1.3.99.5] synonym: "steroid delta4-5alpha-reductase activity" EXACT [EC:1.3.99.5] synonym: "testosterone 5alpha-reductase" BROAD [EC:1.3.99.5] xref: EC:1.3.99.5 xref: MetaCyc:1.3.99.5-RXN is_a: GO:0033765 ! steroid dehydrogenase activity, acting on the CH-CH group of donors [Term] id: GO:0003866 name: 3-phosphoshikimate 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + 3-phosphoshikimate = phosphate + 5-O-(1-carboxyvinyl)-3-phosphoshikimate." [EC:2.5.1.19] subset: gosubset_prok synonym: "3-enol-pyruvoylshikimate-5-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "5-enolpyruvylshikimate-3-phosphate synthase activity" EXACT [EC:2.5.1.19] synonym: "EPSP synthase activity" EXACT [EC:2.5.1.19] synonym: "phosphoenolpyruvate:3-phosphoshikimate 5-O-(1-carboxyvinyl)-transferase activity" EXACT [EC:2.5.1.19] xref: EC:2.5.1.19 xref: MetaCyc:2.5.1.19-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003867 name: 4-aminobutyrate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: 4-aminobutanoate + amino group acceptor = succinate semialdehyde + amino acid." [EC:2.6.1.19, GOC:mah] subset: gosubset_prok synonym: "4-aminobutanoate transaminase activity" EXACT [] synonym: "4-aminobutyrate aminotransferase activity" EXACT [] synonym: "4-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "beta-alanine aminotransferase" RELATED [EC:2.6.1.19] synonym: "beta-alanine--oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.19] synonym: "beta-alanine-oxoglutarate transaminase activity" RELATED [EC:2.6.1.19] synonym: "GABA aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "GABA transaminase activity" EXACT [] synonym: "GABA transferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-amino-N-butyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate aminotransaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyrate transaminase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid aminotransferase activity" EXACT [EC:2.6.1.19] synonym: "gamma-aminobutyric acid transaminase activity" EXACT [] synonym: "gamma-aminobutyric transaminase activity" EXACT [EC:2.6.1.19] synonym: "glutamate-succinic semialdehyde transaminase activity" EXACT [EC:2.6.1.19] xref: EC:2.6.1.19 xref: MetaCyc:GABATRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003868 name: 4-hydroxyphenylpyruvate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxyphenylpyruvate + O2 = homogentisate + CO2." [EC:1.13.11.27] subset: gosubset_prok synonym: "4-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvate:oxygen oxidoreductase (hydroxylating, decarboxylating)" EXACT [EC:1.13.11.27] synonym: "4-hydroxyphenylpyruvic acid dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate dioxygenase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvate oxidase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic acid hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic hydroxylase activity" EXACT [EC:1.13.11.27] synonym: "p-hydroxyphenylpyruvic oxidase activity" EXACT [EC:1.13.11.27] xref: EC:1.13.11.27 xref: MetaCyc:4-HYDROXYPHENYLPYRUVATE-DIOXYGENASE-RXN xref: Reactome:11670 "4-hydroxyphenylpyruvate dioxygenase activity" xref: UM-BBD_enzymeID:e0126 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0003869 name: 4-nitrophenylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 4-nitrophenyl phosphate + H2O = 4-nitrophenol + phosphate." [EC:3.1.3.41] subset: gosubset_prok synonym: "4-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "ecto-p-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "K-pNPPase activity" EXACT [EC:3.1.3.41] synonym: "nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "NPPase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphatase activity" EXACT [EC:3.1.3.41] synonym: "p-nitrophenylphosphate phosphohydrolase activity" EXACT [EC:3.1.3.41] synonym: "para-nitrophenyl phosphatase activity" EXACT [EC:3.1.3.41] synonym: "PNPPase activity" EXACT [EC:3.1.3.41] xref: EC:3.1.3.41 xref: MetaCyc:4-NITROPHENYLPHOSPHATASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003870 name: 5-aminolevulinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + glycine = 5-aminolevulinate + CoA + CO2." [EC:2.3.1.37] subset: gosubset_prok synonym: "5-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "5-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthase activity" EXACT [EC:2.3.1.37] synonym: "ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "ALAS activity" EXACT [EC:2.3.1.37] synonym: "alpha-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-ALA synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinate synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic acid synthetase activity" EXACT [EC:2.3.1.37] synonym: "delta-aminolevulinic synthetase activity" EXACT [EC:2.3.1.37] synonym: "succinyl-CoA:glycine C-succinyltransferase (decarboxylating)" EXACT [EC:2.3.1.37] xref: EC:2.3.1.37 xref: MetaCyc:5-AMINOLEVULINIC-ACID-SYNTHASE-RXN xref: Reactome:11690 "5-aminolevulinate synthase activity" is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0003871 name: 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydropteroyltri-L-glutamate + L-homocysteine = tetrahydropteroyltri-L-glutamate + L-methionine." [EC:2.1.1.14] subset: gosubset_prok synonym: "5-methyltetrahydropteroyltri-L-glutamate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "cobalamin-independent methionine synthase activity" EXACT [EC:2.1.1.14] synonym: "homocysteine methylase activity" EXACT [EC:2.1.1.14] synonym: "MetE" RELATED [EC:2.1.1.14] synonym: "methionine synthase (cobalamin-independent) activity" EXACT [EC:2.1.1.14] synonym: "methyltetrahydropteroylpolyglutamate:homocysteine methyltransferase activity" EXACT [EC:2.1.1.14] synonym: "methyltransferase, tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroylglutamate-homocysteine transmethylase activity" EXACT [EC:2.1.1.14] synonym: "tetrahydropteroyltriglutamate methyltransferase activity" EXACT [EC:2.1.1.14] xref: EC:2.1.1.14 xref: MetaCyc:HOMOCYSMET-RXN is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042085 ! 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity [Term] id: GO:0003872 name: 6-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.11] subset: gosubset_prok synonym: "6-phosphofructokinase reduction" EXACT [] synonym: "6-phosphofructose 1-kinase activity" EXACT [EC:2.7.1.11] synonym: "ATP-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "ATP:D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "D-fructose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphate kinase activity" EXACT [EC:2.7.1.11] synonym: "fructose 6-phosphokinase activity" EXACT [EC:2.7.1.11] synonym: "nucleotide triphosphate-dependent phosphofructokinase activity" EXACT [EC:2.7.1.11] synonym: "PFK" RELATED [EC:2.7.1.11] synonym: "phospho-1,6-fructokinase activity" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.11] synonym: "phosphofructokinase I activity" EXACT [EC:2.7.1.11] synonym: "phosphohexokinase activity" BROAD [EC:2.7.1.11] xref: EC:2.7.1.11 xref: MetaCyc:6PFRUCTPHOS-RXN xref: Reactome:11692 "6-phosphofructokinase activity" is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003873 name: 6-phosphofructo-2-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 6-phosphate = ADP + D-fructose 2,6-bisphosphate." [EC:2.7.1.105] synonym: "6-phosphofructo-2-kinase (phosphorylating)" EXACT [EC:2.7.1.105] synonym: "6-phosphofructose 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "ATP:beta-D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "ATP:D-fructose-6-phosphate 2-phosphotransferase activity" EXACT [EC:2.7.1.105] synonym: "fructose 6-phosphate 2-kinase activity" EXACT [EC:2.7.1.105] synonym: "phosphofructokinase 2 activity" EXACT [EC:2.7.1.105] xref: EC:2.7.1.105 xref: MetaCyc:6-PHOSPHOFRUCTO-2-KINASE-RXN xref: Reactome:11695 "6-phosphofructo-2-kinase activity" is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0003874 name: 6-pyruvoyltetrahydropterin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydropterin = 6-pyruvoyl-5,6,7,8-tetrahydropterin + triphosphate." [EC:4.2.3.12] subset: gosubset_prok synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate lyase activity" EXACT [EC:4.2.3.12] synonym: "2-amino-4-oxo-6-[(1S,2R)-1,2-dihydroxy-3-triphosphooxypropyl]-7,8-dihydroxypteridine triphosphate-lyase (6-pyruvoyl-5,6,7,8-tetrahydropterin-forming)" EXACT [EC:4.2.3.12] synonym: "6-pyruvoyl tetrahydrobiopterin synthase activity" EXACT [EC:4.2.3.12] synonym: "PTPS activity" EXACT [EC:4.2.3.12] xref: EC:4.2.3.12 xref: MetaCyc:4.2.3.12-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0003875 name: ADP-ribosylarginine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-(ADP-D-ribosyl)-L-arginine + H2O = L-arginine + ADP-ribose." [EC:3.2.2.19] subset: gosubset_prok synonym: "ADP-ribose-L-arginine cleavage enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADP-ribose-L-arginine cleaving enzyme activity" EXACT [EC:3.2.2.19] synonym: "ADPribosylarginine hydrolase activity" EXACT [] synonym: "N(omega)-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "omega-protein-N-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein ADP-ribosylarginine hydrolase activity" EXACT [EC:3.2.2.19] synonym: "protein-nomega-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase activity" EXACT [EC:3.2.2.19] xref: EC:3.2.2.19 xref: MetaCyc:ADP-RIBOSYLARGININE-HYDROLASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003876 name: AMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = IMP + NH3." [EC:3.5.4.6] synonym: "5-adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "5-AMP deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenosine 5-phosphate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenosine monophosphate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenyl deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylate deaminase reaction" EXACT [] synonym: "adenylate desaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic acid deaminase activity" EXACT [EC:3.5.4.6] synonym: "adenylic deaminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminase activity" EXACT [EC:3.5.4.6] synonym: "AMP aminohydrolase activity" EXACT [EC:3.5.4.6] synonym: "myoadenylate deaminase activity" NARROW [EC:3.5.4.6] xref: EC:3.5.4.6 xref: MetaCyc:AMP-DEAMINASE-RXN xref: Reactome:11698 "AMP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0003877 name: ATP adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ADP + ATP = phosphate + P(1),P(4)-bis(5'-adenosyl)tetraphosphate." [EC:2.7.7.53] subset: gosubset_prok synonym: "adenine triphosphate adenylyltransferase activity" EXACT [EC:2.7.7.53] synonym: "ADP:ATP adenylyltransferase activity" EXACT [] synonym: "AP-4-A phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "bis(5'-nucleosyl)-tetraphosphate phosphorylase (NDP-forming) activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate alphabeta-phosphorylase (ADP-forming)" EXACT [EC:2.7.7.53] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alpha-beta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "diadenosinetetraphosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] synonym: "dinucleoside oligophosphate alphabeta-phosphorylase activity" EXACT [EC:2.7.7.53] xref: EC:2.7.7.53 xref: MetaCyc:ATP-ADENYLYLTRANSFERASE-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003878 name: ATP citrate synthase activity namespace: molecular_function alt_id: GO:0046913 def: "Catalysis of the reaction: ADP + phosphate + acetyl-CoA + oxaloacetate = ATP + citrate + CoA." [EC:2.3.3.8] comment: Note that this function was formerly EC:4.1.3.8. synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP- phosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate acetyltransferase (isomerizing; ADP-phosphorylating)" EXACT [EC:2.3.3.8] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [(pro-S)-carboxymethyl-forming, ADP-phosphorylating]" RELATED [EC:2.3.3.8] synonym: "adenosine triphosphate citrate lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP citrate (pro-S)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citrate (pro-S)-lyase activity" EXACT [] synonym: "ATP-citrate (pro-S-)-lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP-citric lyase activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase ((pro-S)-CH(2)COO(-)->acetyl-CoA) (ATP- dephosphorylating) activity" EXACT [EC:2.3.3.8] synonym: "ATP:citrate oxaloacetate-lyase [(pro-S)-CH2COO-rightacetyl-CoA] (ATP-dephosphorylating)" RELATED [EC:2.3.3.8] synonym: "citrate cleavage enzyme activity" RELATED [EC:2.3.3.8] synonym: "citrate-ATP lyase activity" EXACT [EC:2.3.3.8] synonym: "citric cleavage enzyme activity" RELATED [EC:2.3.3.8] xref: EC:2.3.3.8 xref: MetaCyc:ATP-CITRATE-PRO-S--LYASE-RXN xref: MetaCyc:PWY-5172 is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0003879 name: ATP phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phospho-D-ribosyl)-ATP + diphosphate = ATP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.17] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-ATP:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.17] synonym: "adenosine triphosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl ATP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP diphosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyl-ATP:pyrophosphate-phosphoribosyl phosphotransferase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate pyrophosphorylase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate synthetase activity" EXACT [EC:2.4.2.17] synonym: "phosphoribosyladenosine triphosphate:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.17] xref: EC:2.4.2.17 xref: MetaCyc:ATPPHOSPHORIBOSYLTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003880 name: protein C-terminal carboxyl O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of a carboxyl group at the C-terminal of a protein." [PMID:8428937] subset: gosubset_prok synonym: "C-terminal protein carboxyl methyltransferase activity" EXACT [] xref: EC:2.1.1.- is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity relationship: part_of GO:0006481 ! C-terminal protein amino acid methylation [Term] id: GO:0003881 name: CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + myo-inositol = CMP + phosphatidyl-1D-myo-inositol." [EC:2.7.8.11] subset: gosubset_prok synonym: "CDP diglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-DG:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol--inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diacylglycerol:myo-inositol-3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDP-diglyceride:inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "CDPdiacylglycerol-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:myo-inositol 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphodiglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol phosphatidyltransferase activity" EXACT [EC:2.7.8.11] synonym: "cytidine diphosphoglyceride-inositol transferase activity" EXACT [EC:2.7.8.11] synonym: "phosphatidylinositol synthase activity" EXACT [] xref: EC:2.7.8.11 xref: MetaCyc:2.7.8.11-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003882 name: CDP-diacylglycerol-serine O-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + L-serine = CMP + O-sn-phosphatidyl-L-serine." [EC:2.7.8.8] subset: gosubset_prok synonym: "CDP-diacylglycerol-L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diacylglycerol:L-serine 3-O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride-L-serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglyceride:serine phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDP-diglycerine-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiacylglycerol-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "CDPdiglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol:L-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "cytidine diphosphoglyceride-serine O-phosphatidyltransferase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthase activity" EXACT [EC:2.7.8.8] synonym: "phosphatidylserine synthetase activity" EXACT [EC:2.7.8.8] synonym: "PS synthase activity" EXACT [EC:2.7.8.8] synonym: "serine exchange enzyme" BROAD [] xref: EC:2.7.8.8 xref: MetaCyc:PHOSPHASERSYN-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0003883 name: CTP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UTP + NH3 = ADP + phosphate + CTP." [EC:6.3.4.2] subset: gosubset_prok synonym: "CTP synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine 5'-triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "cytidine triphosphate synthetase activity" EXACT [EC:6.3.4.2] synonym: "uridine triphosphate aminase activity" EXACT [EC:6.3.4.2] synonym: "UTP--ammonia ligase activity" EXACT [EC:6.3.4.2] synonym: "UTP:ammonia ligase (ADP-forming)" EXACT [EC:6.3.4.2] xref: EC:6.3.4.2 xref: MetaCyc:CTPSYN-RXN xref: Reactome:11718 "CTP synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0003884 name: D-amino-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + O2 = a 2-oxo acid + NH3 + H2O2." [EC:1.4.3.3] subset: gosubset_prok synonym: "D-amino-acid:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.3] synonym: "L-amino acid:O2 oxidoreductase activity" EXACT [EC:1.4.3.3] synonym: "new yellow enzyme" RELATED [EC:1.4.3.3] xref: EC:1.4.3.3 xref: MetaCyc:D-AMINO-ACID-OXIDASE-RXN xref: Reactome:11719 "D-amino-acid oxidase activity" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0003885 name: D-arabinono-1,4-lactone oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinono-1,4-lactone + O2 = dehydro-D-arabinono-1,4-lactone + H2O2." [EC:1.1.3.37] subset: gosubset_prok synonym: "D-arabinono-1,4-lactone:oxygen oxidoreductase activity" EXACT [EC:1.1.3.37] xref: EC:1.1.3.37 xref: MetaCyc:1.1.3.37-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003886 name: DNA (cytosine-5-)-methyltransferase activity namespace: molecular_function alt_id: GO:0008326 def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA containing cytosine = S-adenosyl-L-homocysteine + DNA containing 5-methylcytosine." [EC:2.1.1.37] comment: Note that EC:2.1.1.73 was deleted from EC as the reaction is performed by DNA (cytosine-5-)-methyltransferase (EC:2.1.1.37). subset: gosubset_prok synonym: "cytosine 5-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "cytosine DNA methylase activity" BROAD [EC:2.1.1.37] synonym: "cytosine DNA methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "cytosine-specific DNA methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic acid (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "deoxyribonucleic methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA 5-cytosine methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C(5) methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine c5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine C5 methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA cytosine methylase activity" BROAD [EC:2.1.1.37] synonym: "DNA-cytosine 5-methylase activity" EXACT [EC:2.1.1.37] synonym: "DNA-cytosine methyltransferase activity" BROAD [EC:2.1.1.37] synonym: "methylphosphotriester-DNA methyltransferase activity" RELATED [EC:2.1.1.37] synonym: "modification methylase activity" RELATED [EC:2.1.1.37] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.37] synonym: "S-adenosyl-L-methionine:DNA (cytosine-5-)-methyltransferase activity" EXACT [EC:2.1.1.37] synonym: "site-specific DNA-methyltransferase (cytosine-specific) activity" NARROW [EC:2.1.1.37] synonym: "type II DNA methylase activity" RELATED [EC:2.1.1.37] xref: EC:2.1.1.37 xref: MetaCyc:2.1.1.73-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0090116 ! C-5 methylation of cytosine [Term] id: GO:0003887 name: DNA-directed DNA polymerase activity namespace: molecular_function alt_id: GO:0003888 alt_id: GO:0003889 alt_id: GO:0003890 alt_id: GO:0003891 alt_id: GO:0003893 alt_id: GO:0003894 alt_id: GO:0003895 alt_id: GO:0008723 alt_id: GO:0015999 alt_id: GO:0016000 alt_id: GO:0016448 alt_id: GO:0016449 alt_id: GO:0016450 alt_id: GO:0016451 alt_id: GO:0016452 alt_id: GO:0019984 def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1); the synthesis of DNA from deoxyribonucleotide triphosphates in the presence of a DNA template and primer." [EC:2.7.7.7, ISBN:0198547684] subset: gosubset_prok synonym: "alpha DNA polymerase activity" NARROW [] synonym: "beta DNA polymerase activity" NARROW [] synonym: "delta DNA polymerase activity" NARROW [] synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic acid duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic duplicase activity" EXACT [EC:2.7.7.7] synonym: "deoxyribonucleic polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA duplicase activity" EXACT [EC:2.7.7.7] synonym: "DNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.7] synonym: "DNA polymerase alpha" NARROW [EC:2.7.7.7] synonym: "DNA polymerase beta" NARROW [EC:2.7.7.7] synonym: "DNA polymerase gamma" NARROW [EC:2.7.7.7] synonym: "DNA polymerase I" NARROW [EC:2.7.7.7] synonym: "DNA polymerase II" NARROW [EC:2.7.7.7] synonym: "DNA polymerase III" NARROW [EC:2.7.7.7] synonym: "DNA polymerase V activity" NARROW [] synonym: "DNA replicase activity" EXACT [EC:2.7.7.7] synonym: "DNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.7] synonym: "duplicase" BROAD [EC:2.7.7.7] synonym: "epsilon DNA polymerase activity" NARROW [] synonym: "eta DNA polymerase activity" NARROW [] synonym: "gamma DNA-directed DNA polymerase activity" NARROW [] synonym: "iota DNA polymerase activity" NARROW [] synonym: "kappa DNA polymerase activity" NARROW [] synonym: "Klenow fragment" NARROW [EC:2.7.7.7] synonym: "lambda DNA polymerase activity" NARROW [] synonym: "mu DNA polymerase activity" NARROW [] synonym: "nu DNA polymerase activity" NARROW [] synonym: "sequenase" RELATED [EC:2.7.7.7] synonym: "sigma DNA polymerase activity" NARROW [] synonym: "Taq DNA polymerase" NARROW [EC:2.7.7.7] synonym: "Taq Pol I" NARROW [EC:2.7.7.7] synonym: "Tca DNA polymerase" NARROW [EC:2.7.7.7] synonym: "theta DNA polymerase activity" NARROW [] synonym: "zeta DNA polymerase activity" NARROW [] xref: EC:2.7.7.- xref: EC:2.7.7.7 xref: MetaCyc:DNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:11722 "DNA-directed DNA polymerase activity" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003892 name: proliferating cell nuclear antigen namespace: molecular_function alt_id: GO:0005661 def: "OBSOLETE. A nuclear protein that associates as a trimer and then interacts with delta DNA polymerase and epsilon DNA polymerase, acting as an auxiliary factor for DNA replication and DNA repair." [ISBN:0123668387] comment: This term was made obsolete because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. synonym: "PCNA" EXACT [] is_obsolete: true [Term] id: GO:0003896 name: DNA primase activity namespace: molecular_function alt_id: GO:0003897 alt_id: GO:0003898 def: "Catalysis of the synthesis of a short RNA primer on a DNA template, providing a free 3'-OH that can be extended by DNA-directed DNA polymerases. Catalyzed by a DNA-directed RNA polymerase that forms a complex with alpha DNA polymerase." [GOC:mah, ISBN:0716720094] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0003899 ! DNA-directed RNA polymerase activity [Term] id: GO:0003899 name: DNA-directed RNA polymerase activity namespace: molecular_function alt_id: GO:0000129 def: "Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'." [EC:2.7.7.6] subset: gosubset_prok synonym: "C ribonucleic acid formation factors" RELATED [EC:2.7.7.6] synonym: "C RNA formation factors" RELATED [EC:2.7.7.6] synonym: "deoxyribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA nucleotidyltransferase activity" EXACT [EC:2.7.7.6] synonym: "DNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.6] synonym: "DNA-directed RNA polymerase I activity" NARROW [] synonym: "DNA-directed RNA polymerase II activity" NARROW [] synonym: "DNA-directed RNA polymerase III activity" NARROW [] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA nucleotidyltransferase (DNA-directed) activity" EXACT [EC:2.7.7.6] synonym: "RNA polymerase I activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase II activity" NARROW [EC:2.7.7.6] synonym: "RNA polymerase III activity" NARROW [EC:2.7.7.6] synonym: "transcriptase" BROAD [EC:2.7.7.6] xref: EC:2.7.7.6 xref: MetaCyc:DNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:11745 "DNA-directed RNA polymerase activity" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003900 name: DNA-directed RNA polymerase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase I complex ; GO:0005736'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003901 name: DNA-directed RNA polymerase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase II, core complex ; GO:0005665'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003902 name: DNA-directed RNA polymerase III activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.6] comment: This term was made obsolete because it represents the specific complex represented by the cellular component term 'DNA-directed RNA polymerase III complex ; GO:0005666'. is_obsolete: true replaced_by: GO:0003899 [Term] id: GO:0003904 name: deoxyribodipyrimidine photo-lyase activity namespace: molecular_function def: "Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). The enzyme catalyzes the reactivation by light of irradiated DNA. A similar reactivation of irradiated RNA is probably due to a separate enzyme." [EC:4.1.99.3] subset: gosubset_prok synonym: "deoxyribocyclobutadipyrimidine pyrimidine-lyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribodipyrimidine photolyase activity" EXACT [] synonym: "deoxyribonucleate pyrimidine dimer lyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "deoxyribonucleic photolyase activity" EXACT [EC:4.1.99.3] synonym: "dipyrimidine photolyase (photosensitive)" EXACT [EC:4.1.99.3] synonym: "DNA cyclobutane dipyrimidine photolyase activity" EXACT [EC:4.1.99.3] synonym: "DNA-photoreactivating enzyme" RELATED [EC:4.1.99.3] synonym: "photolyase activity" EXACT [EC:4.1.99.3] synonym: "photoreactivating enzyme activity" RELATED [EC:4.1.99.3] synonym: "phr A photolyase activity" EXACT [EC:4.1.99.3] synonym: "PhrB photolyase activity" EXACT [EC:4.1.99.3] synonym: "PRE" RELATED [EC:4.1.99.3] xref: EC:4.1.99.3 xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003905 name: alkylbase DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0004036 def: "Catalysis of the hydrolysis of alkylated DNA; recognizes and removes alkylated purines and pyrimidines by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic or apyrimidinic (AP) site. Enzyme has broad substrate specificity, being able to recognize alkylpurines, alkylpyrimidines or ethenopurines." [EC:3.2.2.21, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase II" RELATED [EC:3.2.2.21] synonym: "AlkA" RELATED [EC:3.2.2.21] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.21] synonym: "alkylbase DNA glycosidase activity" EXACT [] synonym: "deoxyribonucleate 3-methyladenine glycosidase II" RELATED [EC:3.2.2.21] synonym: "DNA glycosidase II activity" EXACT [EC:3.2.2.21] synonym: "DNA-3-methyladenine glycosidase II activity" EXACT [] synonym: "DNA-3-methyladenine glycosylase II" RELATED [EC:3.2.2.21] xref: EC:3.2.2.21 xref: MetaCyc:3.2.2.21-RXN is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0003906 name: DNA-(apurinic or apyrimidinic site) lyase activity namespace: molecular_function def: "Catalysis of the cleavage of the C-O-P bond 3' to the apurinic or apyrimidinic site in DNA by a beta-elimination reaction, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate." [EC:4.2.99.18] subset: gosubset_prok synonym: "AP endonuclease class I activity" NARROW [EC:4.2.99.18] synonym: "AP lyase activity" EXACT [EC:4.2.99.18] synonym: "AP site-DNA 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "deoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "DNA-(apurinic or apyrimidinic site) 5'-phosphomonoester-lyase activity" EXACT [EC:4.2.99.18] synonym: "E. coli endonuclease III" RELATED [EC:4.2.99.18] synonym: "E. coli endonuclease III activity" NARROW [EC:4.2.99.18] synonym: "endodeoxyribonuclease (apurinic or apyrimidinic) activity" EXACT [EC:4.2.99.18] synonym: "endonuclease VIII activity" RELATED [] synonym: "micrococcus luteus UV endonuclease" NARROW [EC:4.2.99.18] synonym: "Micrococcus luteus UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "Phage-T(4) UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "phage-T4 UV endonuclease" BROAD [EC:4.2.99.18] synonym: "Phage-T4 UV endonuclease activity" NARROW [EC:4.2.99.18] synonym: "X-ray endonuclease III" RELATED [EC:4.2.99.18] xref: EC:4.2.99.18 xref: MetaCyc:4.2.99.18-RXN xref: Reactome:12450 "DNA-(apurinic or apyrimidinic site) lyase activity" is_a: GO:0016835 ! carbon-oxygen lyase activity [Term] id: GO:0003908 name: methylated-DNA-[protein]-cysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: DNA (containing 6-O-methylguanine) + (protein)-L-cysteine = DNA (without 6-O-methylguanine) + protein S-methyl-L-cysteine." [EC:2.1.1.63] subset: gosubset_prok synonym: "6-O-methylguanine-DNA methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "DNA-6-O-methylguanine:[protein]-L-cysteine S-methyltransferase activity" EXACT [] synonym: "DNA-6-O-methylguanine:protein-L-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "methylated-DNA-protein-cysteine S-methyltransferase activity" EXACT [EC:2.1.1.63] synonym: "MGMT" EXACT [] synonym: "O-6-methylguanine-DNA-alkyltransferase activity" EXACT [EC:2.1.1.63] synonym: "O6-alkylguanine-DNA alkyltransferase" BROAD [] xref: EC:2.1.1.63 xref: MetaCyc:2.1.1.63-RXN xref: Reactome:12455 "methylated-DNA-[protein]-cysteine S-methyltransferase activity" is_a: GO:0008172 ! S-methyltransferase activity [Term] id: GO:0003909 name: DNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 3'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another; requires an energy source such as ATP or NAD+." [ISBN:0716720094] subset: gosubset_prok xref: EC:6.5.1.- xref: Reactome:12459 "DNA ligase activity" is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003910 name: DNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + diphosphate + deoxyribonucleotide(n+m)." [EC:6.5.1.1] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic acid repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic acid-joining enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.1] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.1] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.1] synonym: "DNA joinase activity" BROAD [EC:6.5.1.1] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.1] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.1] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.1] synonym: "polydeoxyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.1] synonym: "polynucleotide ligase (ATP) activity" EXACT [EC:6.5.1.1] synonym: "sealase activity" RELATED [EC:6.5.1.1] xref: EC:6.5.1.1 xref: MetaCyc:DNA-LIGASE-ATP-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003911 name: DNA ligase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + deoxyribonucleotide(n) + deoxyribonucleotide(m) = AMP + nicotinamide nucleotide + deoxyribonucleotide(n+m)." [EC:6.5.1.2] subset: gosubset_prok synonym: "deoxyribonucleate ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic acid ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic joinase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic ligase" BROAD [EC:6.5.1.2] synonym: "deoxyribonucleic repair enzyme" RELATED [EC:6.5.1.2] synonym: "deoxyribonucleic-joining enzyme" RELATED [EC:6.5.1.2] synonym: "DNA joinase activity" BROAD [EC:6.5.1.2] synonym: "DNA ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "DNA repair enzyme activity" RELATED [EC:6.5.1.2] synonym: "DNA-joining enzyme" RELATED [EC:6.5.1.2] synonym: "poly(deoxyribonucleotide):poly(deoxyribonucleotide) ligase (AMP-forming, NMN-forming)" EXACT [EC:6.5.1.2] synonym: "Polydeoxyribonucleotide synthase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD)" EXACT [EC:6.5.1.2] synonym: "polydeoxyribonucleotide synthase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase" BROAD [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD(+)) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD)" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (NAD+) activity" EXACT [EC:6.5.1.2] synonym: "polynucleotide ligase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase (nicotinamide adenine dinucleotide)" EXACT [EC:6.5.1.2] synonym: "polynucleotide synthetase activity" EXACT [EC:6.5.1.2] xref: EC:6.5.1.2 xref: MetaCyc:DNA-LIGASE-NAD+-RXN is_a: GO:0003909 ! DNA ligase activity [Term] id: GO:0003912 name: DNA nucleotidylexotransferase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1)." [EC:2.7.7.31] synonym: "addase activity" EXACT [EC:2.7.7.31] synonym: "deoxynucleotidyl terminal transferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic acid nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "deoxyribonucleic nucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "nucleoside-triphosphate:DNA deoxynucleotidylexotransferase activity" EXACT [EC:2.7.7.31] synonym: "TdT" RELATED [EC:2.7.7.31] synonym: "terminal addition enzyme activity" RELATED [EC:2.7.7.31] synonym: "terminal deoxynucleotide transferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxynucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal deoxyribonucleotidyltransferase activity" EXACT [EC:2.7.7.31] synonym: "terminal transferase activity" EXACT [EC:2.7.7.31] xref: EC:2.7.7.31 xref: MetaCyc:DNA-NUCLEOTIDYLEXOTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0003913 name: DNA photolyase activity namespace: molecular_function def: "Catalysis of the repair of a photoproduct resulting from ultraviolet irradiation of two adjacent pyrimidine residues in DNA." [GOC:mah, PMID:11124949] subset: gosubset_prok xref: EC:4.1.99.- xref: MetaCyc:DEOXYRIBODIPYRIMIDINE-PHOTOLYASE-RXN is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0003914 name: DNA (6-4) photolyase activity namespace: molecular_function def: "Catalysis of the reaction: pyrimidine-pyrimidone (6-4) photoproduct (in DNA) = 2 pyrimidine residues (in DNA). Catalyzes the reactivation of ultraviolet-irradiated DNA." [GOC:mah, PMID:11124949] is_a: GO:0003913 ! DNA photolyase activity [Term] id: GO:0003916 name: DNA topoisomerase activity namespace: molecular_function alt_id: GO:0009387 def: "Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA." [GOC:mah, PMID:8811192] subset: gosubset_prok xref: EC:5.99.1.- xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003677 ! DNA binding is_a: GO:0016853 ! isomerase activity [Term] id: GO:0003917 name: DNA topoisomerase type I activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle." [PMID:8811192] comment: Note that a further distinction, between type IA and type IB topoisomerases, is based on sequence or structural similarity between gene products that possess type I catalytic activity. subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.2] synonym: "DNA topoisomerase I activity" NARROW [] synonym: "nicking-closing enzyme activity" RELATED [EC:5.99.1.2] synonym: "omega-protein activity" RELATED [EC:5.99.1.2] synonym: "relaxing enzyme activity" RELATED [EC:5.99.1.2] synonym: "swivelase activity" RELATED [EC:5.99.1.2] synonym: "topoisomerase" BROAD [EC:5.99.1.2] synonym: "type I DNA topoisomerase activity" EXACT [] synonym: "type I topoisomerase activity" EXACT [] synonym: "untwisting enzyme activity" RELATED [EC:5.99.1.2] xref: EC:5.99.1.2 xref: MetaCyc:5.99.1.2-RXN is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003918 name: DNA topoisomerase (ATP-hydrolyzing) activity namespace: molecular_function def: "Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [PMID:8811192] subset: gosubset_prok synonym: "deoxyribonucleate topoisomerase" BROAD [EC:5.99.1.3] synonym: "deoxyribonucleic topoisomerase activity" EXACT [EC:5.99.1.3] synonym: "DNA gyrase activity" EXACT [] synonym: "DNA topoisomerase (ATP-hydrolysing)" BROAD [EC:5.99.1.3] synonym: "DNA topoisomerase II" RELATED [EC:5.99.1.3] synonym: "DNA topoisomerase IV activity" EXACT [] synonym: "DNA topoisomerase type II activity" EXACT [] synonym: "DNA-gyrase activity" EXACT [EC:5.99.1.3] synonym: "topoisomerase" BROAD [EC:5.99.1.3] synonym: "topoisomerase II" EXACT [] synonym: "type II DNA topoisomerase activity" EXACT [EC:5.99.1.3] xref: EC:5.99.1.3 xref: MetaCyc:5.99.1.3-RXN xref: Wikipedia:Type_II_topoisomerase is_a: GO:0003916 ! DNA topoisomerase activity [Term] id: GO:0003919 name: FMN adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + FMN = diphosphate + FAD." [EC:2.7.7.2] subset: gosubset_prok synonym: "adenosine triphosphate-riboflavin mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "adenosine triphosphate-riboflavine mononucleotide transadenylase activity" EXACT [EC:2.7.7.2] synonym: "ATP:FMN adenylyltransferase activity" EXACT [] synonym: "FAD diphosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "FAD synthetase activity" EXACT [EC:2.7.7.2] synonym: "flavin adenine dinucleotide synthetase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.2] synonym: "riboflavin mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] synonym: "riboflavine adenine dinucleotide adenylyltransferase activity" EXACT [EC:2.7.7.2] xref: EC:2.7.7.2 xref: MetaCyc:FADSYN-RXN xref: Reactome:12494 "FMN adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0003920 name: GMP reductase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NH3 + NADP+ = guanosine 5'-phosphate + NADPH + H+." [EC:1.7.1.7] comment: Note that this function was formerly EC:1.6.6.8. subset: gosubset_prok synonym: "guanosine 5'-monophosphate oxidoreductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine 5'-phosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanosine monophosphate reductase activity" EXACT [EC:1.7.1.7] synonym: "guanylate reductase activity" RELATED [EC:1.7.1.7] synonym: "inosine-5'-phosphate:NADP+ oxidoreductase (aminating)" EXACT [EC:1.7.1.7] synonym: "NADPH2:guanosine-5'-phosphate oxidoreductase (deaminating)" EXACT [EC:1.7.1.7] synonym: "NADPH:GMP oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] synonym: "NADPH:guanosine-5'-phosphate oxidoreductase (deaminating) activity" EXACT [EC:1.7.1.7] xref: EC:1.7.1.7 xref: MetaCyc:GMP-REDUCT-RXN xref: Reactome:12504 "GMP reductase activity" is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0003921 name: GMP synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + NH3 = AMP + diphosphate + GMP." [EC:6.3.4.1] synonym: "guanylate synthetase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine 5'-monophosphate aminase activity" EXACT [EC:6.3.4.1] synonym: "Xanthosine-5'-phosphate--ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate-ammonia ligase activity" EXACT [EC:6.3.4.1] synonym: "xanthosine-5'-phosphate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.4.1] synonym: "XMP aminase activity" EXACT [EC:6.3.4.1] xref: EC:6.3.4.1 xref: MetaCyc:GMP-SYN-NH3-RXN xref: Reactome:12506 "GMP synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds relationship: part_of GO:0006177 ! GMP biosynthetic process [Term] id: GO:0003922 name: GMP synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + xanthosine 5'-phosphate + L-glutamine + H2O = AMP + diphosphate + GMP + L-glutamate." [EC:6.3.5.2] subset: gosubset_prok synonym: "glutamine amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "GMP synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.2] synonym: "GMP synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.2] synonym: "guanosine 5'-monophosphate synthetase activity" EXACT [EC:6.3.5.2] synonym: "guanosine monophosphate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "guanylate synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.2] synonym: "xanthosine 5'-phosphate amidotransferase activity" EXACT [EC:6.3.5.2] synonym: "xanthosine-5'-phosphate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.2] xref: EC:6.3.5.2 xref: MetaCyc:GMP-SYN-GLUT-RXN xref: Wikipedia:GMP_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003923 name: GPI-anchor transamidase activity namespace: molecular_function def: "Catalysis of the formation of the linkage between a protein and a glycosylphosphatidylinositol anchor. The reaction probably occurs by subjecting a peptide bond to nucleophilic attack by the amino group of ethanolamine-GPI, transferring the protein from a signal peptide to the GPI anchor." [ISBN:0471331309 "Biochemical Pathways"] xref: EC:3.-.-.- xref: Reactome:12511 "GPI-anchor transamidase activity" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0003924 name: GTPase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + H2O = GDP + phosphate." [ISBN:0198547684] subset: gosubset_prok synonym: "ARF small monomeric GTPase activity" NARROW [] synonym: "dynamin GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase activity" NARROW [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" RELATED [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" RELATED [] synonym: "hydrolase activity, acting on acid anhydrides, acting on GTP, involved in cellular and subcellular movement" BROAD [] synonym: "protein-synthesizing GTPase activity" NARROW [] synonym: "protein-synthesizing GTPase activity, elongation" NARROW [] synonym: "protein-synthesizing GTPase activity, initiation" NARROW [] synonym: "protein-synthesizing GTPase activity, termination" NARROW [] synonym: "Rab small monomeric GTPase activity" NARROW [] synonym: "Ran small monomeric GTPase activity" NARROW [] synonym: "Ras small monomeric GTPase activity" NARROW [] synonym: "RHEB small monomeric GTPase activity" NARROW [] synonym: "Rho small monomeric GTPase activity" NARROW [] synonym: "Sar small monomeric GTPase activity" NARROW [] synonym: "signal-recognition-particle GTPase activity" NARROW [] synonym: "small monomeric GTPase activity" NARROW [] synonym: "tubulin GTPase activity" NARROW [] xref: Reactome:12513 "GTPase activity" is_a: GO:0017111 ! nucleoside-triphosphatase activity relationship: part_of GO:0006184 ! GTP catabolic process [Term] id: GO:0003925 name: small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Small monomeric enzymes with a molecular mass of 21 kDa that are distantly related to the alpha-subunit of heterotrimeric G-protein GTPase. They are involved in cell-growth regulation (RAS subfamily), membrane vesicle traffic and uncoating (RAB and ARF subfamilies), nuclear protein import (RAN subfamily) and organization of the cytoskeleton (Rho and Rac subfamilies)." [EC:3.6.5.2, GOC:mah, ISBN:0198547684, MetaCyc:3.6.1.47-RXN] comment: This term was made obsolete because it represents a gene product and contains cellular component information. is_obsolete: true replaced_by: GO:0003924 [Term] id: GO:0003926 name: ARF small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003927 name: heterotrimeric G-protein GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. GTP-hydrolyzing enzymes, where GTP and GDP alternate in binding. Includes stimulatory and inhibitory G-proteins such as Gs, Gi, Go and Golf, targeting adenylate cyclase and/or potassium ion and calcium ion channels; Gq stimulating phospholipase C; transducin activating cGMP phosphodiesterase; gustducin activating cAMP phosphodiesterase." [EC:3.6.5.1, ISBN:0198547684, MetaCyc:3.6.1.46-RXN] comment: This term was made obsolete because it represents a cellular component. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0005834 [Term] id: GO:0003928 name: RAB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0016191 consider: GO:0016192 [Term] id: GO:0003929 name: RAN small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0006606 [Term] id: GO:0003930 name: RAS small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 [Term] id: GO:0003931 name: Rho small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Any member of the Rho subfamily of the RAS superfamily of monomeric GTPases. Proteins in the Rho subfamily are involved in relaying signals from cell-surface receptors to the actin cytoskeleton." [EC:3.6.1.47, GOC:mah, ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0007010 [Term] id: GO:0003932 name: SAR small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0046903 [Term] id: GO:0003933 name: GTP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the imidazole ring of GTP, releasing formate. Two C-N bonds are hydrolyzed and the pentase unit is isomerized." [GOC:jl, http://cancerweb.ncl.ac.uk] subset: gosubset_prok xref: EC:3.5.4.- is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003934 name: GTP cyclohydrolase I activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 2 H2O = formate + 2-amino-4-hydroxy-6-(erythro-1,2,3-trihydroxypropyl)-dihydropteridine triphosphate." [EC:3.5.4.16] subset: gosubset_prok synonym: "dihydroneopterin triphosphate synthase activity" EXACT [EC:3.5.4.16] synonym: "GTP 7,8-8,9-dihydrolase activity" EXACT [EC:3.5.4.16] synonym: "GTP 8-formylhydrolase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate 8-deformylase activity" EXACT [EC:3.5.4.16] synonym: "guanosine triphosphate cyclohydrolase activity" EXACT [EC:3.5.4.16] xref: EC:3.5.4.16 xref: MetaCyc:GTP-CYCLOHYDRO-I-RXN is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003935 name: GTP cyclohydrolase II activity namespace: molecular_function def: "Catalysis of the reaction: GTP + 3 H2O = formate + 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + diphosphate." [EC:3.5.4.25] subset: gosubset_prok synonym: "GTP 7,8-8,9-dihydrolase (diphosphate-forming)" EXACT [EC:3.5.4.25] synonym: "GTP-8-formylhydrolase activity" EXACT [EC:3.5.4.25] synonym: "guanosine triphosphate cyclohydrolase II" RELATED [EC:3.5.4.25] xref: EC:3.5.4.25 xref: MetaCyc:GTP-CYCLOHYDRO-II-RXN is_a: GO:0003933 ! GTP cyclohydrolase activity [Term] id: GO:0003936 name: hydrogen-transporting two-sector ATPase activity namespace: molecular_function alt_id: GO:0004006 alt_id: GO:0008729 def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out)." [EC:3.6.3.14, TC:3.A.3.-.-] comment: This term was made obsolete because it refers to a bifunctional gene product. synonym: "proton-transporting two-sector ATPase activity" EXACT [] is_obsolete: true consider: GO:0046933 consider: GO:0046961 [Term] id: GO:0003937 name: IMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + H2O = 5-formamido-1-(5-phosphoribosyl)imidazole-4-carboxamide." [EC:3.5.4.10] subset: gosubset_prok synonym: "IMP 1,2-hydrolase (decyclizing)" EXACT [EC:3.5.4.10] synonym: "IMP synthetase activity" EXACT [EC:3.5.4.10] synonym: "inosinate cyclohydrolase activity" EXACT [EC:3.5.4.10] synonym: "inosinicase activity" EXACT [EC:3.5.4.10] xref: EC:3.5.4.10 xref: MetaCyc:IMPCYCLOHYDROLASE-RXN xref: Reactome:12558 "IMP cyclohydrolase activity" is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0003938 name: IMP dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: inosine 5'-phosphate + NAD+ + H2O = xanthosine 5'-phosphate + NADH + H+." [EC:1.1.1.205] subset: gosubset_prok synonym: "IMP oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "IMP:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosinate dehydrogenase activity" RELATED [EC:1.1.1.205] synonym: "inosine 5'-monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosine monophosphate oxidoreductase activity" EXACT [EC:1.1.1.205] synonym: "inosine-5'-phosphate dehydrogenase activity" EXACT [EC:1.1.1.205] synonym: "inosinic acid dehydrogenase activity" RELATED [EC:1.1.1.205] xref: EC:1.1.1.205 xref: MetaCyc:IMP-DEHYDROG-RXN xref: Reactome:12563 "IMP dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003939 name: L-iditol 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-iditol + NAD+ = L-sorbose + NADH + H+." [EC:1.1.1.14] comment: Note that enzymes with this activity also act on D-glucitol (giving D-fructose) and other closely related sugar alcohols. subset: gosubset_prok synonym: " L-iditol:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "glucitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol (sorbitol) dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "L-iditol:NAD oxidoreductase activity" EXACT [EC:1.1.1.14] synonym: "NAD+-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-dependent sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] synonym: "NAD-sorbitol dehydrogenase" RELATED [EC:1.1.1.14] synonym: "polyol dehydrogenase activity" BROAD [EC:1.1.1.14] synonym: "sorbitol dehydrogenase activity" RELATED [EC:1.1.1.14] xref: EC:1.1.1.14 xref: MetaCyc:L-IDITOL-2-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003940 name: L-iduronidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-L-iduronosidic linkages in desulfated dermatan." [EC:3.2.1.76] synonym: "alpha-L-iduronidase activity" EXACT [EC:3.2.1.76] synonym: "glycosaminoglycan alpha-L-iduronohydrolase activity" EXACT [EC:3.2.1.76] xref: EC:3.2.1.76 xref: MetaCyc:3.2.1.76-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0003941 name: L-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine = pyruvate + NH3." [EC:4.3.1.17] comment: Note that this function was formerly EC:4.3.1.13. subset: gosubset_prok synonym: "L-hydroxyaminoacid dehydratase activity" BROAD [] synonym: "L-serine ammonia-lyase (pyruvate-forming) activity" EXACT [EC:4.3.1.17] synonym: "L-serine deaminase activity" EXACT [] synonym: "L-serine dehydratase activity" BROAD [EC:4.3.1.17] synonym: "L-serine hydro-lyase (deaminating) activity" EXACT [] synonym: "serine deaminase activity" BROAD [EC:4.3.1.17] xref: EC:4.3.1.17 xref: MetaCyc:4.3.1.17-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0003942 name: N-acetyl-gamma-glutamyl-phosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-L-glutamate 5-semialdehyde + NADP+ + phosphate = N-acetyl-5-glutamyl phosphate + NADPH + H+." [EC:1.2.1.38] subset: gosubset_prok synonym: "N-acetyl-glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate gamma-semialdehyde:NADP oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetyl-L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamate 5-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "N-acetylglutamic gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.38] synonym: "NAGSA dehydrogenase activity" BROAD [EC:1.2.1.38] synonym: "reductase, acetyl-gamma-glutamyl phosphate" EXACT [EC:1.2.1.38] xref: EC:1.2.1.38 xref: MetaCyc:N-ACETYLGLUTPREDUCT-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0003943 name: N-acetylgalactosamine-4-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 4-sulfate groups of the N-acetyl-D-galactosamine 4-sulfate units of chondroitin sulfate and dermatan sulfate." [EC:3.1.6.12] subset: gosubset_prok synonym: "acetylgalactosamine 4-sulfatase activity" EXACT [EC:3.1.6.12] synonym: "arylsulfatase B" EXACT [] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.12] synonym: "N-acetyl-D-galactosamine-4-sulfate 4-sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine 4-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.12] synonym: "N-acetylgalactosamine-4-sulphatase activity" EXACT [] xref: EC:3.1.6.12 xref: MetaCyc:3.1.6.12-RXN xref: Wikipedia:Arylsulfatase_B is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0003944 name: N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein N-acetyl-D-glucosaminyl-phospho-D-mannose + H2O = N-acetyl-D-glucosamine + glycoprotein phospho-D-mannose." [EC:3.1.4.45] synonym: "2-acetamido-2-deoxy-alpha-D-glucose 1-phosphodiester acetamidodeoxyglucohydrolase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetyl-D-glucosamine-1-phosphodiester N-acetylglucosaminidase activity" EXACT [EC:3.1.4.45] synonym: "alpha-N-acetylglucosaminyl phosphodiesterase activity" EXACT [EC:3.1.4.45] synonym: "glycoprotein-N-acetyl-D-glucosaminyl-phospho-D-mannose N-acetyl-D-glucosaminylphosphohydrolase activity" EXACT [EC:3.1.4.45] synonym: "lysosomal alpha-N-acetylglucosaminidase activity" NARROW [EC:3.1.4.45] synonym: "phosphodiester glycosidase activity" EXACT [EC:3.1.4.45] xref: EC:3.1.4.45 xref: MetaCyc:3.1.4.45-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0003945 name: N-acetyllactosamine synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetyl-D-glucosamine = UDP + N-acetyllactosamine." [EC:2.4.1.90] subset: gosubset_prok synonym: "acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta-N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "beta1-4GalT" RELATED [EC:2.4.1.90] synonym: "Gal-T" RELATED [EC:2.4.1.90] synonym: "lactosamine synthase activity" EXACT [EC:2.4.1.90] synonym: "lactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "lactose synthetase A protein" RELATED [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta-1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetylglucosamine (beta1,4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "N-acetyllactosamine synthetase activity" EXACT [EC:2.4.1.90] synonym: "NAL synthetase activity" EXACT [EC:2.4.1.90] synonym: "UDP-beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-Gal:N-acetylglucosamine beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose N-acetylglucosamine beta-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-1,4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose-N-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDP-galactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:N-acetylglucosaminide beta1-4-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose-N-acetylglucosamine beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetyl-D-glucosamine 4-beta-D-galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "UDPgalactose:N-acetylglucosaminyl(beta1-4)galactosyltransferase activity" EXACT [EC:2.4.1.90] synonym: "uridine diphosphogalactose-acetylglucosamine galactosyltransferase activity" EXACT [EC:2.4.1.90] xref: EC:2.4.1.90 xref: MetaCyc:N-ACETYLLACTOSAMINE-SYNTHASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0003947 name: (N-acetylneuraminyl)-galactosylglucosylceramide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + (N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide = UDP + N-acetyl-D-galactosaminyl-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide." [EC:2.4.1.92] synonym: "asialo-GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "beta-1,4N-aetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GalNAc-T activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "GM2 synthase activity" EXACT [EC:2.4.1.92] synonym: "GM2/GD2-synthase activity" EXACT [EC:2.4.1.92] synonym: "UDP acetylgalactosamine-(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:(N-acetylneuraminyl)-D-galactosyl-D-glucosylceramide N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetyl-D-galactosamine:1-O-[O-(N-acetyl-alpha-neuraminosyl)-(2->3)-O-beta-D-galactopyranosyl-(1->4)-beta-D-glucopyranosyl]-ceramide 1,4-beta-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "UDP-N-acetylgalactosamine GM3 N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-acetylneuraminylgalactosylglucosylceramide acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-ganglioside GM3 acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] synonym: "uridine diphosphoacetylgalactosamine-hematoside acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.92] xref: EC:2.4.1.92 xref: MetaCyc:2.4.1.92-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0003948 name: N4-(beta-N-acetylglucosaminyl)-L-asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: N(4)-(beta-N-acetyl-D-glucosaminyl)-L-asparagine + H2O = N-acetyl-beta-glucosaminylamine + L-aspartate." [EC:3.5.1.26] subset: gosubset_prok synonym: "4-N-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylamine deaspartylase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglucosylaminidase activity" EXACT [EC:3.5.1.26] synonym: "aspartylglycosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "beta-aspartylglucosylamine amidohydrolase activity" EXACT [EC:3.5.1.26] synonym: "glucosylamidase activity" RELATED [EC:3.5.1.26] synonym: "glycosylasparaginase activity" EXACT [EC:3.5.1.26] synonym: "N-aspartyl-beta-glucosaminidase activity" EXACT [EC:3.5.1.26] synonym: "N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.26] xref: EC:3.5.1.26 xref: MetaCyc:3.5.1.26-RXN is_a: GO:0004067 ! asparaginase activity [Term] id: GO:0003949 name: 1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide = N-(5'-phospho-D-1'-ribulosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide." [EC:5.3.1.16] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide aldose-ketose-isomerase activity" EXACT [EC:5.3.1.16] synonym: "1-(5-phosphoribosyl)-5-[(5-phosphoribosylamino)methylideneamino]imidazole-4-carboxamide ketol-isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(5'-phospho-D-ribosylformimino)-5-amino-1-(5''-phosphoribosyl)-4-imidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "N-(phosphoribosylformimino) aminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase activity" EXACT [EC:5.3.1.16] synonym: "phosphoribosylformiminoaminophosphoribosylimidazolecarboxamide isomerase activity" EXACT [EC:5.3.1.16] xref: EC:5.3.1.16 xref: MetaCyc:PRIBFAICARPISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0003950 name: NAD+ ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + (ADP-D-ribosyl)(n)-acceptor = nicotinamide + (ADP-D-ribosyl)(n+1)-acceptor." [EC:2.4.2.30] subset: gosubset_prok synonym: "ADP-ribosyltransferase (polymerizing) activity" EXACT [EC:2.4.2.30] synonym: "NAD ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:poly(adenine-diphosphate-D-ribosyl)-acceptor ADP-D-ribosyl-transferase activity" EXACT [EC:2.4.2.30] synonym: "poly(adenosine diphosphate ribose) polymerase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose) synthetase activity" EXACT [EC:2.4.2.30] synonym: "poly(ADP-ribose)polymerase activity" EXACT [EC:2.4.2.30] xref: EC:2.4.2.30 xref: MetaCyc:NAD+-ADP-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003951 name: NAD+ kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NAD+ = ADP + NADP+." [EC:2.7.1.23] subset: gosubset_prok synonym: "ATP:NAD+ 2'-phosphotransferase activity" EXACT [EC:2.7.1.23] synonym: "DPN kinase activity" RELATED [EC:2.7.1.23] synonym: "NAD kinase activity" EXACT [] synonym: "NADK" RELATED [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase (phosphorylating)" EXACT [EC:2.7.1.23] synonym: "nicotinamide adenine dinucleotide kinase activity" EXACT [EC:2.7.1.23] xref: EC:2.7.1.23 xref: MetaCyc:NAD-KIN-RXN xref: Reactome:12598 "NAD+ kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0003952 name: NAD+ synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deamido-NAD+ + L-glutamine + H2O = AMP + diphosphate + NAD+ + L-glutamate." [EC:6.3.5.1] subset: gosubset_prok synonym: "deamido-NAD+:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.1] synonym: "desamidonicotinamide adenine dinucleotide amidotransferase activity" EXACT [EC:6.3.5.1] synonym: "DPN synthetase activity" EXACT [EC:6.3.5.1] synonym: "NAD synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "NAD synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD(+) synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.1] synonym: "NAD+ synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.1] synonym: "NAD+ synthetase (glutamine-hydrolyzing)" EXACT [EC:6.3.5.1] synonym: "nicotinamide adenine dinucleotide synthetase (glutamine) activity" EXACT [EC:6.3.5.1] xref: EC:6.3.5.1 xref: MetaCyc:NAD-SYNTH-GLN-RXN xref: Reactome:12600 "NAD+ synthase (glutamine-hydrolyzing) activity" xref: Wikipedia:NAD+_synthase_(glutamine-hydrolysing) is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0003953 name: NAD+ nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: NAD+ + H2O = nicotinamide + ADP-ribose." [EC:3.2.2.5] subset: gosubset_prok synonym: "ADP-ribosyl cyclase activity" RELATED [EC:3.2.2.5] synonym: "diphosphopyridine nucleosidase activity" EXACT [EC:3.2.2.5] synonym: "DPN hydrolase activity" EXACT [EC:3.2.2.5] synonym: "DPNase activity" EXACT [EC:3.2.2.5] synonym: "NAD glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD hydrolase activity" EXACT [EC:3.2.2.5] synonym: "NAD nucleosidase activity" EXACT [] synonym: "NAD+ glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "NADase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide glycohydrolase activity" EXACT [EC:3.2.2.5] synonym: "nicotinamide adenine dinucleotide nucleosidase activity" EXACT [EC:3.2.2.5] xref: EC:3.2.2.5 xref: MetaCyc:NADNUCLEOSID-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0003954 name: NADH dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + acceptor = NAD+ + reduced acceptor." [EC:1.6.99.3] subset: gosubset_prok synonym: "beta-NADH dehydrogenase dinucleotide activity" EXACT [EC:1.6.99.3] synonym: "cytochrome c reductase activity" RELATED [EC:1.6.99.3] synonym: "diaphorase activity" BROAD [EC:1.6.99.3] synonym: "dihydrocodehydrogenase I dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "dihydronicotinamide adenine dinucleotide dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyridine diaphorase activity" EXACT [EC:1.6.99.3] synonym: "diphosphopyrinase activity" EXACT [EC:1.6.99.3] synonym: "DPNH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH diaphorase activity" EXACT [EC:1.6.99.3] synonym: "NADH hydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH-menadione oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "NADH2 dehydrogenase activity" EXACT [EC:1.6.99.3] synonym: "NADH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.3] synonym: "NADH:cytochrome c oxidoreductase activity" NARROW [EC:1.6.99.3] synonym: "reduced diphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.99.3] synonym: "type I dehydrogenase activity" RELATED [EC:1.6.99.3] xref: EC:1.6.99.3 xref: MetaCyc:NADH-DEHYDROGENASE-RXN is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0003955 name: NAD(P)H dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)(+) + a hydroquinone." [EC:1.6.5.2] subset: gosubset_prok synonym: "azoreductase activity" BROAD [EC:1.6.5.2] synonym: "dehydrogenase, reduced nicotinamide adenine dinucleotide (phosphate, quinone) activity" EXACT [EC:1.6.5.2] synonym: "diaphorase activity" BROAD [EC:1.6.5.2] synonym: "DT-diaphorase activity" EXACT [EC:1.6.5.2] synonym: "flavoprotein NAD(P)H-quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "menadione oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H menadione reductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H(2) dehydrogenase (quinone) activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H-quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H2 dehydrogenase (quinone)" EXACT [EC:1.6.5.2] synonym: "NAD(P)H: menadione oxidoreductase activity" BROAD [EC:1.6.5.2] synonym: "NAD(P)H:(quinone-acceptor)oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NAD(P)H:quinone oxidoreductase activity" EXACT [EC:1.6.5.2] synonym: "NADH-menadione reductase activity" NARROW [EC:1.6.5.2] synonym: "naphthoquinone reductase activity" EXACT [EC:1.6.5.2] synonym: "Naphthoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "NQO1" RELATED [EC:1.6.5.2] synonym: "p-benzoquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "phylloquinone reductase activity" NARROW [EC:1.6.5.2] synonym: "QR1" RELATED [EC:1.6.5.2] synonym: "quinone reductase activity" EXACT [EC:1.6.5.2] synonym: "reduced NAD(P)H dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "reduced nicotinamide-adenine dinucleotide (phosphate) dehydrogenase activity" EXACT [EC:1.6.5.2] synonym: "viologen accepting pyridine nucleotide oxidoreductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin K reductase activity" NARROW [EC:1.6.5.2] synonym: "vitamin-K reductase activity" NARROW [EC:1.6.5.2] xref: EC:1.6.5.2 xref: MetaCyc:NQOR-RXN xref: UM-BBD_enzymeID:e0202 is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0003956 name: NAD(P)+-protein-arginine ADP-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: NAD(P)+ + L-arginine = nicotinamide + N2-(ADP-D-ribosyl)-L-arginine." [EC:2.4.2.31] synonym: "ADP-ribosyltransferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADP-ribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "mono(ADPribosyl)transferase activity" BROAD [EC:2.4.2.31] synonym: "NAD(+):L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)(+)--arginine ADP-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD(P)+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)+:protein-L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "NAD(P)-arginine ADP-ribosyltransferase activity" EXACT [] synonym: "NAD+:L-arginine ADP-D-ribosyltransferase activity" EXACT [EC:2.4.2.31] synonym: "peptidyl-arginine ADP-ribosylation activity" EXACT [] synonym: "protein-arginine ADP-ribosyltransferase activity" EXACT [] xref: EC:2.4.2.31 xref: MetaCyc:2.4.2.31-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0003957 name: NAD(P)+ transhydrogenase (B-specific) activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is B-specific (i.e. the pro-S hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to both NAD+ and NADP+." [EC:1.6.1.1, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3] subset: gosubset_prok synonym: "H+-thase" BROAD [EC:1.6.1.1] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NAD(P) transhydrogenase (B-specific) activity" EXACT [] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1] synonym: "NADPH:NAD+ oxidoreductase (B-specific)" EXACT [EC:1.6.1.1] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1] synonym: "nicotinamide nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] synonym: "non-energy-linked transhydrogenase activity" EXACT [EC:1.6.1.1] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.1] xref: EC:1.6.1.1 xref: MetaCyc:PYRNUTRANSHYDROGEN-RXN is_a: GO:0008746 ! NAD(P) transhydrogenase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0003958 name: NADPH-hemoprotein reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + n oxidized hemoprotein = NADP+ + n reduced hemoprotein." [EC:1.6.2.4] subset: gosubset_prok synonym: "aldehyde reductase (NADPH-dependent) activity" RELATED [EC:1.6.2.4] synonym: "CPR activity" RELATED [EC:1.6.2.4] synonym: "cytochrome c reductase (reduced nicotinamide adenine dinucleotide phosphate, NADPH, NADPH-dependent) activity" NARROW [EC:1.6.2.4] synonym: "cytochrome P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "dihydroxynicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "FAD-cytochrome c reductase activity" RELATED [EC:1.6.2.4] synonym: "ferrihemoprotein P-450 reductase activity" RELATED [EC:1.6.2.4] synonym: "NADP--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADP--cytochrome reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--cytochrome P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferricytochrome c oxidoreductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH--ferrihemoprotein reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-cytochrome P-450 oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-cytochrome p-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH-dependent cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "NADPH-ferrihemoprotein reductase activity" EXACT [] synonym: "NADPH:cytochrome c reductase activity" EXACT [] synonym: "NADPH:cytochrome P450 reductase activity" EXACT [] synonym: "NADPH:ferrihemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:hemoprotein oxidoreductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P-450 reductase activity" EXACT [EC:1.6.2.4] synonym: "NADPH:P450 reductase activity" NARROW [EC:1.6.2.4] synonym: "POR" RELATED [EC:1.6.2.4] synonym: "reduced nicotinamide adenine dinucleotide phosphate-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "reductase, cytochrome c (reduced nicotinamide adenine dinucleotide phosphate) activity" NARROW [EC:1.6.2.4] synonym: "TPNH(2) cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH-cytochrome c reductase activity" NARROW [EC:1.6.2.4] synonym: "TPNH2 cytochrome c reductase activity" EXACT [EC:1.6.2.4] xref: EC:1.6.2.4 xref: MetaCyc:NADPH--FERRIHEMOPROTEIN-REDUCTASE-RXN is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0003959 name: NADPH dehydrogenase activity namespace: molecular_function alt_id: GO:0008468 alt_id: GO:0016660 def: "Catalysis of the reaction: NADPH + H+ + quinone acceptor = NADP+ + hydroquinone." [EC:1.6.99.1] subset: gosubset_prok synonym: "dihydronicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2 diaphorase activity" EXACT [EC:1.6.99.1] synonym: "NADPH2-dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:(acceptor) oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "NADPH:acceptor oxidoreductase activity" EXACT [EC:1.6.99.1] synonym: "old yellow enzyme" RELATED [EC:1.6.99.1] synonym: "OYE" RELATED [EC:1.6.99.1] synonym: "reduced nicotinamide adenine dinucleotide phosphate dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH dehydrogenase activity" EXACT [EC:1.6.99.1] synonym: "TPNH-diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine diaphorase activity" EXACT [EC:1.6.99.1] synonym: "triphosphopyridine nucleotide diaphorase activity" EXACT [EC:1.6.99.1] xref: EC:1.6.99.1 xref: MetaCyc:NADPH-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0523 is_a: GO:0016651 ! oxidoreductase activity, acting on NADH or NADPH [Term] id: GO:0003960 name: NADPH:quinone reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + quinone = NADP+ + semiquinone." [EC:1.6.5.5] subset: gosubset_prok synonym: "NADPH:quinone oxidoreductase activity" EXACT [EC:1.6.5.5] synonym: "quinone oxidoreductase activity" BROAD [EC:1.6.5.5] synonym: "zeta-crystallin activity" NARROW [EC:1.6.5.5] xref: EC:1.6.5.5 xref: MetaCyc:QOR-RXN is_a: GO:0016655 ! oxidoreductase activity, acting on NADH or NADPH, quinone or similar compound as acceptor [Term] id: GO:0003961 name: O-acetylhomoserine aminocarboxypropyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: O-acetyl-L-homoserine + methanethiol = L-methionine + acetate." [EC:2.5.1.49] comment: Note that this function was formerly EC:4.2.99.10. subset: gosubset_prok synonym: "4.2.99.9" RELATED [] synonym: "O-acetyl-L-homoserine acetate-lyase (adding methanethiol) activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "O-acetyl-L-homoserine:methanethiol 3-amino-3-carboxypropyltransferase activity" EXACT [EC:2.5.1.49] synonym: "O-acetylhomoserine (thiol)-lyase activity" EXACT [] synonym: "O-acetylhomoserine sulfhydrolase activity" EXACT [EC:2.5.1.49] synonym: "OAH sulfhydrylase activity" EXACT [EC:2.5.1.49] xref: EC:2.5.1.49 xref: MetaCyc:O-ACETYLHOMOSERINE-THIOL-LYASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003962 name: cystathionine gamma-synthase activity namespace: molecular_function alt_id: GO:0000505 def: "Catalysis of the reaction: O-succinyl-L-homoserine + L-cysteine = cystathionine + succinate." [EC:2.5.1.48] comment: Formerly EC 4.2.99.9. subset: gosubset_prok synonym: "CTT gamma synthase activity" EXACT [] synonym: "cystathionine g-synthase activity" EXACT [] synonym: "cystathionine gamma synthase activity" EXACT [] synonym: "cystathionine synthase activity" EXACT [EC:2.5.1.48] synonym: "cystathionine synthetase activity" EXACT [EC:2.5.1.48] synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "homoserine transsuccinylase activity" BROAD [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine (thiol)-lyase activity" EXACT [] synonym: "O-succinyl-L-homoserine succinate-lyase (adding cysteine) activity" EXACT [EC:2.5.1.48] synonym: "O-succinyl-L-homoserine succinate-lyase activity" EXACT [] synonym: "O-succinylhomoserine (thiol)-lyase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthase activity" EXACT [EC:2.5.1.48] synonym: "O-succinylhomoserine synthetase activity" EXACT [EC:2.5.1.48] synonym: "O4-succinyl-L-homoserine:L-cysteine S-(3-amino-3-carboxypropyl)transferase activity" EXACT [EC:2.5.1.48] xref: EC:2.5.1.48 xref: MetaCyc:O-SUCCHOMOSERLYASE-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0003963 name: RNA-3'-phosphate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA 3'-terminal-phosphate = AMP + diphosphate + RNA terminal-2',3'-cyclic-phosphate." [EC:6.5.1.4] subset: gosubset_prok synonym: "RNA 3'-terminal phosphate cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA cyclase activity" EXACT [EC:6.5.1.4] synonym: "RNA-3'-phosphate:RNA ligase (cyclizing, AMP-forming)" EXACT [EC:6.5.1.4] xref: EC:6.5.1.4 xref: MetaCyc:RNA-3-PHOSPHATE-CYCLASE-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0003964 name: RNA-directed DNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time." [EC:2.7.7.49] subset: gosubset_prok synonym: "deoxynucleoside-triphosphate:DNA deoxynucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "DNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.49] synonym: "reverse transcriptase activity" EXACT [EC:2.7.7.49] synonym: "revertase activity" RELATED [EC:2.7.7.49] synonym: "RNA revertase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent deoxyribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.49] synonym: "RNA-dependent DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RNA-directed DNA polymerase, group II intron encoded" NARROW [] synonym: "RNA-directed DNA polymerase, transposon encoded" NARROW [] synonym: "RNA-instructed DNA polymerase activity" EXACT [EC:2.7.7.49] synonym: "RT" RELATED [EC:2.7.7.49] xref: EC:2.7.7.49 xref: MetaCyc:RNA-DIRECTED-DNA-POLYMERASE-RXN xref: Reactome:10568 "RNA-directed DNA polymerase activity" is_a: GO:0034061 ! DNA polymerase activity [Term] id: GO:0003966 name: RNA-directed DNA polymerase, transposon encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003967 name: RNA-directed DNA polymerase, group II intron encoded namespace: molecular_function def: "OBSOLETE. Catalysis of RNA-template-directed extension of the 3'- end of a DNA strand by one deoxynucleotide at a time; cannot initiate a chain de novo." [EC:2.7.7.49] comment: This term was made obsolete because it does not represent a function distinct from its parent term 'RNA-directed DNA polymerase'. is_obsolete: true replaced_by: GO:0003964 [Term] id: GO:0003968 name: RNA-directed RNA polymerase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + RNA (n) = diphosphate + RNA (n+1); uses an RNA template." [EC:2.7.7.48, GOC:mah] subset: gosubset_prok synonym: "3D polymerase activity" EXACT [EC:2.7.7.48] synonym: "nucleoside-triphosphate:RNA nucleotidyltransferase (RNA-directed)" EXACT [EC:2.7.7.48] synonym: "PB1 proteins" RELATED [EC:2.7.7.48] synonym: "PB2 proteins" RELATED [EC:2.7.7.48] synonym: "phage f2 replicase" NARROW [EC:2.7.7.48] synonym: "polymerase L" RELATED [EC:2.7.7.48] synonym: "Q-beta replicase activity" EXACT [EC:2.7.7.48] synonym: "RDRP" RELATED [EC:2.7.7.48] synonym: "ribonucleic acid replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic acid-dependent ribonucleic acid polymerase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic replicase activity" EXACT [EC:2.7.7.48] synonym: "ribonucleic synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA nucleotidyltransferase (RNA-directed) activity" EXACT [EC:2.7.7.48] synonym: "RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "RNA synthetase activity" RELATED [EC:2.7.7.48] synonym: "RNA-dependent ribonucleate nucleotidyltransferase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA polymerase activity" EXACT [EC:2.7.7.48] synonym: "RNA-dependent RNA replicase activity" EXACT [EC:2.7.7.48] synonym: "transcriptase" BROAD [EC:2.7.7.48] xref: EC:2.7.7.48 xref: MetaCyc:RNA-DIRECTED-RNA-POLYMERASE-RXN xref: Reactome:12642 "RNA-directed RNA polymerase activity" is_a: GO:0034062 ! RNA polymerase activity [Term] id: GO:0003969 name: RNA editase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a biological process. is_obsolete: true [Term] id: GO:0003972 name: RNA ligase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ribonucleotide (n) + ribonucleotide (m) = AMP + diphosphate + ribonucleotide (n+m)." [EC:6.5.1.3] subset: gosubset_prok synonym: "poly(ribonucleotide):poly(ribonucleotide) ligase (AMP-forming)" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide ligase activity" EXACT [EC:6.5.1.3] synonym: "polyribonucleotide synthase (ATP) activity" EXACT [EC:6.5.1.3] synonym: "ribonucleic ligase activity" BROAD [EC:6.5.1.3] xref: EC:6.5.1.3 xref: MetaCyc:RNA-LIGASE-ATP-RXN is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0003973 name: (S)-2-hydroxy-acid oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-hydroxy-acid + O2 = 2-oxo acid + H2O2." [EC:1.1.3.15] subset: gosubset_prok synonym: "(S)-2-hydroxy-acid:oxygen 2-oxidoreductase" EXACT [EC:1.1.3.15] synonym: "hydroxy-acid oxidase A activity" NARROW [EC:1.1.3.15] synonym: "hydroxy-acid oxidase B activity" NARROW [EC:1.1.3.15] synonym: "hydroxyacid oxidase A" RELATED [EC:1.1.3.15] synonym: "L-2-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "L-alpha-hydroxy acid oxidase" EXACT [EC:1.1.3.15] synonym: "oxidase, L-2-hydroxy acid" EXACT [EC:1.1.3.15] xref: EC:1.1.3.15 xref: MetaCyc:S-2-HYDROXY-ACID-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0003974 name: UDP-N-acetylglucosamine 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-galactosamine." [EC:5.1.3.7] subset: gosubset_prok synonym: "UDP acetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-GlcNAc 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "UDP-N-acetyl-D-glucosamine 4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine 5'-diphospho-N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphate N-acetylglucosamine-4-epimerase activity" EXACT [EC:5.1.3.7] synonym: "uridine diphosphoacetylglucosamine epimerase activity" EXACT [EC:5.1.3.7] xref: EC:5.1.3.7 xref: MetaCyc:UDP-N-ACETYLGLUCOSAMINE-4-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003975 name: UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UMP + N-acetyl-D-glucosaminyl-diphosphodolichol." [EC:2.7.8.15] subset: gosubset_prok synonym: "chitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.7.8.15] synonym: "dolichol phosphate N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "GlcNAc-1-P transferase activity" EXACT [EC:2.7.8.15] synonym: "N-acetylglucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-acetylglucosamine-dolichol phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-D-N-acetylglucosamine N-acetylglucosamine 1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-GlcNAc:dolichyl-phosphate GlcNAc-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichol phosphate N-acetyl-D-glucosamine-1-phosphate transferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate N-acetyl-D-glucosaminephosphotransferase activity" EXACT [EC:2.7.8.15] synonym: "UDP-N-acetylglucosamine-dolichyl-phosphate N-acetylglucosamine-1-phosphate transferase activity" EXACT [] synonym: "uridine diphosphoacetylglucosamine-dolichyl phosphate acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.15] xref: EC:2.7.8.15 xref: MetaCyc:2.7.8.15-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003976 name: UDP-N-acetylglucosamine-lysosomal-enzyme N-acetylglucosaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lysosomal-enzyme D-mannose = UMP + lysosomal-enzyme N-acetyl-D-glucosaminyl-phospho-D-mannose." [EC:2.7.8.17] synonym: "lysosomal enzyme precursor acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminyl phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "N-acetylglucosaminylphosphotransferase activity" RELATED [EC:2.7.8.17] synonym: "UDP-GlcNAc:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetyl-D-glucosamine:lysosomal-enzyme N-acetylglucosaminephosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:glycoprotein N-acetylglucosaminyl-1-phosphotransferase activity" EXACT [EC:2.7.8.17] synonym: "UDP-N-acetylglucosamine:lysosomal enzyme N-acetylglucosamine-1-phosphotransferase activity" EXACT [EC:2.7.8.17] xref: EC:2.7.8.17 xref: MetaCyc:2.7.8.17-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0003977 name: UDP-N-acetylglucosamine diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + N-acetyl-alpha-D-glucosamine 1-phosphate = diphosphate + UDP-N-acetyl-D-glucosamine." [EC:2.7.7.23] subset: gosubset_prok synonym: "acetylglucosamine 1-phosphate uridylyltransferase" BROAD [EC:2.7.7.23] synonym: "GlmU uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "N-acetylglucosamine-1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UDP-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-GlcNAc pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UDP-N-acetylglucosamine pyrophosphorylase activity" EXACT [] synonym: "uridine diphosphate-N-acetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine phosphorylase activity" EXACT [EC:2.7.7.23] synonym: "uridine diphosphoacetylglucosamine pyrophosphorylase activity" EXACT [EC:2.7.7.23] synonym: "UTP:2-acetamido-2-deoxy-alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] synonym: "UTP:N-acetyl-alpha-D-glucosamine-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.23] xref: EC:2.7.7.23 xref: MetaCyc:NAG1P-URIDYLTRANS-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0003978 name: UDP-glucose 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose = UDP-galactose." [EC:5.1.3.2] subset: gosubset_prok synonym: "4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "galactowaldenase activity" RELATED [EC:5.1.3.2] synonym: "UDP-D-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDP-glucose epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPG-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPgalactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "UDPglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate galactose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphate glucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphospho-galactose-4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose 4-epimerase activity" EXACT [EC:5.1.3.2] synonym: "uridine diphosphoglucose epimerase activity" EXACT [EC:5.1.3.2] xref: EC:5.1.3.2 xref: MetaCyc:UDPGLUCEPIM-RXN xref: Reactome:12673 "UDP-glucose 4-epimerase activity" is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0003979 name: UDP-glucose 6-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + 2 NAD+ + H2O = UDP-glucuronate + 2 NADH + H+." [EC:1.1.1.22] subset: gosubset_prok xref: EC:1.1.1.22 xref: MetaCyc:UGD-RXN xref: Reactome:12674 "UDP-glucose 6-dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0003980 name: UDP-glucose:glycoprotein glucosyltransferase activity namespace: molecular_function def: "Catalysis of the addition of UDP-glucose on to asparagine-linked (N-linked) oligosaccharides of the form Man7-9GlcNAc2 on incorrectly folded glycoproteins." [PMID:10764828] synonym: "UGGT activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0003983 name: UTP:glucose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose." [EC:2.7.7.9] subset: gosubset_prok synonym: "glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UDP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG phosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UDPG pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine 5'-diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphate-D-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "uridine-diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.9] synonym: "UTP-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] synonym: "UTP:alpha-D-glucose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.9] xref: EC:2.7.7.9 xref: MetaCyc:GLUC1PURIDYLTRANS-RXN xref: Reactome:12708 "UTP:glucose-1-phosphate uridylyltransferase activity" is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0003984 name: acetolactate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 pyruvate = 2-acetolactate + CO2." [EC:2.2.1.6] comment: Note that this function was formerly EC:4.1.3.18. subset: gosubset_prok synonym: "acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "acetolactate pyruvate-lyase (carboxylating) activity" EXACT [EC:2.2.1.6] synonym: "acetolactic synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxy acid synthetase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetohydroxyacid synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthase activity" EXACT [EC:2.2.1.6] synonym: "alpha-acetolactate synthetase activity" EXACT [EC:2.2.1.6] synonym: "pyruvate:pyruvate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.6] xref: EC:2.2.1.6 xref: MetaCyc:ACETOLACTSYN-RXN is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0003985 name: acetyl-CoA C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA." [EC:2.3.1.9] subset: gosubset_prok synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.9] synonym: "3-oxothiolase activity" EXACT [EC:2.3.1.9] synonym: "acetoacetyl-CoA thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:acetyl-CoA C-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "acetyl-CoA:N-acetyltransferase activity" EXACT [EC:2.3.1.9] synonym: "beta-acetoacetyl coenzyme A thiolase activity" EXACT [EC:2.3.1.9] synonym: "thiolase II" RELATED [EC:2.3.1.9] xref: EC:2.3.1.9 xref: MetaCyc:ACETYL-COA-ACETYLTRANSFER-RXN xref: Reactome:12710 "acetyl-CoA C-acetyltransferase activity" xref: UM-BBD_enzymeID:e0144 is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0003986 name: acetyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O = CoA + acetate." [EC:3.1.2.1] subset: gosubset_prok synonym: "acetyl coenzyme A acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA acylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA deacylase activity" EXACT [EC:3.1.2.1] synonym: "acetyl-CoA thiol esterase activity" EXACT [EC:3.1.2.1] xref: EC:3.1.2.1 xref: MetaCyc:ACETYL-COA-HYDROLASE-RXN xref: Reactome:12713 "acetyl-CoA hydrolase activity" is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0003987 name: acetate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA." [EC:6.2.1.1] subset: gosubset_prok synonym: "acetate thiokinase activity" BROAD [EC:6.2.1.1] synonym: "acetate to acetyl-CoA" RELATED [] synonym: "acetate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.1] synonym: "acetic thiokinase activity" EXACT [EC:6.2.1.1] synonym: "acetyl activating enzyme" RELATED [EC:6.2.1.1] synonym: "acetyl CoA ligase activity" EXACT [EC:6.2.1.1] synonym: "acetyl CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl coenzyme A synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-activating enzyme activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "acetyl-coenzyme A synthase activity" EXACT [EC:6.2.1.1] synonym: "ACS" RELATED [EC:6.2.1.1] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.1] synonym: "short chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.1] synonym: "short-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.1] xref: EC:6.2.1.1 xref: MetaCyc:ACETATE--COA-LIGASE-RXN xref: Reactome:12714 "acetate-CoA ligase activity" is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003988 name: acetyl-CoA C-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA." [EC:2.3.1.16] subset: gosubset_prok synonym: "2-keto-acyl thiolase activity" EXACT [] synonym: "2-methylacetoacetyl-CoA thiolase" BROAD [EC:2.3.1.16] synonym: "3-ketoacyl CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-ketoacyl-CoA thiolase activity" EXACT [] synonym: "3-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "3-oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "6-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "acetoacetyl-CoA beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "acetyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "acyl-CoA:acetyl-CoA C-acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketoadipyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "beta-ketothiolase activity" EXACT [EC:2.3.1.16] synonym: "KAT" RELATED [EC:2.3.1.16] synonym: "ketoacyl-CoA acyltransferase activity" EXACT [EC:2.3.1.16] synonym: "ketoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "long-chain 3-oxoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "oxoacyl-coenzyme A thiolase activity" EXACT [EC:2.3.1.16] synonym: "pro-3-ketoacyl-CoA thiolase activity" EXACT [EC:2.3.1.16] synonym: "thiolase I" RELATED [EC:2.3.1.16] xref: EC:2.3.1.16 xref: MetaCyc:KETOACYLCOATHIOL-RXN xref: Reactome:12715 "acetyl-CoA C-acyltransferase activity" xref: UM-BBD_enzymeID:e0653 is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0003989 name: acetyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA." [EC:6.4.1.2] subset: gosubset_prok synonym: "acetyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.2] synonym: "acetyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.2] xref: EC:6.4.1.2 xref: MetaCyc:ACETYL-COA-CARBOXYLTRANSFER-RXN xref: Reactome:12716 "acetyl-CoA carboxylase activity" is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0003990 name: acetylcholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: acetylcholine + H2O = choline + acetate." [EC:3.1.1.7] subset: gosubset_prok synonym: "AcCholE" RELATED [EC:3.1.1.7] synonym: "acetyl.beta-methylcholinesterase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine acetylhydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylcholine hydrolase activity" EXACT [EC:3.1.1.7] synonym: "acetylthiocholinesterase activity" EXACT [EC:3.1.1.7] synonym: "choline esterase I activity" EXACT [EC:3.1.1.7] synonym: "true cholinesterase activity" EXACT [EC:3.1.1.7] xref: EC:3.1.1.7 xref: MetaCyc:ACETYLCHOLINESTERASE-RXN is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0003991 name: acetylglutamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acetyl-L-glutamate = ADP + N-acetyl-L-glutamate 5-phosphate." [EC:2.7.2.8] subset: gosubset_prok synonym: "acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "ATP:N-acetyl-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate kinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamate phosphokinase activity" EXACT [EC:2.7.2.8] synonym: "N-acetylglutamic 5-phosphotransferase activity" EXACT [EC:2.7.2.8] xref: EC:2.7.2.8 xref: MetaCyc:ACETYLGLUTKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0003992 name: N2-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity namespace: molecular_function alt_id: GO:0047318 def: "Catalysis of the reaction: N2-acetyl-L-ornithine + 2-oxoglutarate = N-acetyl-L-glutamate 5-semialdehyde + L-glutamate." [EC:2.6.1.11] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:2-oxoglutarate 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine 5-aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine aminotransferase activity" BROAD [] synonym: "acetylornithine delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "acetylornithine transaminase activity" BROAD [EC:2.6.1.11] synonym: "ACOAT activity" EXACT [EC:2.6.1.11] synonym: "N(2)-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N-acetylornithine-delta-transaminase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetyl-L-ornithine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.11] synonym: "N2-acetylornithine 5-aminotransferase activity" EXACT [] synonym: "N2-acetylornithine 5-transaminase activity" EXACT [EC:2.6.1.11] synonym: "succinylornithine aminotransferase activity" BROAD [EC:2.6.1.11] xref: EC:2.6.1.11 xref: MetaCyc:ACETYLORNTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0003993 name: acid phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum." [EC:3.1.3.2] subset: gosubset_prok synonym: "acid monophosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid nucleoside diphosphate phosphatase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphohydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoester hydrolase activity" EXACT [EC:3.1.3.2] synonym: "acid phosphomonoesterase activity" EXACT [EC:3.1.3.2] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.2] synonym: "orthophosphoric-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphate-monoester phosphohydrolase (acid optimum)" EXACT [EC:3.1.3.2] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.2] synonym: "uteroferrin" RELATED [EC:3.1.3.2] xref: EC:3.1.3.2 xref: MetaCyc:ACID-PHOSPHATASE-RXN xref: Reactome:9271 "acid phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0003994 name: aconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = cis-aconitate + H2O = isocitrate; i.e. the interconversion of citrate and isocitrate via the labile, enzyme-bound intermediate cis-aconitate. Water is removed from one part of the citrate molecule and added back to a different atom to form isocitrate." [EC:4.2.1.3] subset: gosubset_prok synonym: "aconitase activity" EXACT [] synonym: "cis-aconitase activity" EXACT [EC:4.2.1.3] synonym: "citrate hydro-lyase activity" BROAD [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase (cis-aconitate-forming)" EXACT [EC:4.2.1.3] synonym: "citrate(isocitrate) hydro-lyase activity" EXACT [EC:4.2.1.3] xref: EC:4.2.1.3 xref: MetaCyc:ACONITATEDEHYDR-RXN xref: Reactome:12740 "aconitate hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0003995 name: acyl-CoA dehydrogenase activity namespace: molecular_function alt_id: GO:0019109 def: "Catalysis of the reaction: acyl-CoA + acceptor = 2,3-dehydroacyl-CoA + reduced acceptor." [EC:1.3.99.3] subset: gosubset_prok synonym: "acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA reductase activity" EXACT [GOC:mah] synonym: "acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.3] synonym: "fatty acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "fatty-acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "general acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "long-chain acyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.3] synonym: "medium-chain acyl-CoA dehydrogenase activity" NARROW [EC:1.3.99.3] synonym: "medium-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.3] xref: EC:1.3.99.- xref: EC:1.3.99.3 xref: MetaCyc:ACYLCOADEHYDROG-RXN xref: MetaCyc:LONG-CHAIN-FATTY-ACYL-COA-REDUCTASE-RXN xref: Reactome:4266 "acyl-CoA dehydrogenase activity" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0003996 name: acyl-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl + ATP + CoASH = AMP + diphosphate + acyl-CoA." [GOC:mah] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0003997 name: acyl-CoA oxidase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + O2 = trans-2,3-dehydroacyl-CoA + H2O2." [EC:1.3.3.6] subset: gosubset_prok synonym: "acyl coenzyme A oxidase activity" EXACT [EC:1.3.3.6] synonym: "acyl-CoA:oxygen 2-oxidoreductase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-CoA oxidase activity" EXACT [EC:1.3.3.6] synonym: "fatty acyl-coenzyme A oxidase activity" EXACT [EC:1.3.3.6] xref: EC:1.3.3.6 xref: MetaCyc:ACYL-COA-OXIDASE-RXN xref: Reactome:12745 "acyl-CoA oxidase activity" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0003998 name: acylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an acyl phosphate + H2O = a carboxylate + phosphate." [EC:3.6.1.7] subset: gosubset_prok synonym: "1,3-diphosphoglycerate phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetic phosphatase activity" EXACT [EC:3.6.1.7] synonym: "acetylphosphatase activity" EXACT [EC:3.6.1.7] synonym: "acylphosphate phosphohydrolase activity" EXACT [EC:3.6.1.7] synonym: "GP 1-3" RELATED [EC:3.6.1.7] synonym: "Ho 1-3" RELATED [EC:3.6.1.7] xref: EC:3.6.1.7 xref: MetaCyc:ACYLPHOSPHATASE-RXN is_a: GO:0016818 ! hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [Term] id: GO:0003999 name: adenine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + diphosphate = adenine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.7] subset: gosubset_prok synonym: "adenine phosphoribosylpyrophosphate transferase activity" EXACT [EC:2.4.2.7] synonym: "adenosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "adenylate pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "adenylic pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP diphosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP pyrophosphorylase activity" EXACT [EC:2.4.2.7] synonym: "AMP-pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "AMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.7] synonym: "APRT activity" EXACT [EC:2.4.2.7] synonym: "transphosphoribosidase activity" RELATED [EC:2.4.2.7] xref: EC:2.4.2.7 xref: MetaCyc:ADENPRIBOSYLTRAN-RXN xref: Reactome:12749 "adenine phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004000 name: adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3." [EC:3.5.4.4] subset: gosubset_prok synonym: "adenosine aminohydrolase activity" EXACT [EC:3.5.4.4] synonym: "adenosine deaminase reaction" EXACT [] xref: EC:3.5.4.4 xref: MetaCyc:ADENODEAMIN-RXN xref: Reactome:6985 "adenosine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004001 name: adenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenosine = ADP + AMP." [EC:2.7.1.20, PMID:11223943] subset: gosubset_prok synonym: "adenosine 5-phosphotransferase activity" EXACT [] synonym: "adenosine kinase (phosphorylating)" EXACT [EC:2.7.1.20] synonym: "ATP:adenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.20] xref: EC:2.7.1.20 xref: MetaCyc:ADENOSINE-KINASE-RXN xref: Reactome:6989 "adenosine kinase activity" is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004003 name: ATP-dependent DNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of the DNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003678 ! DNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008094 ! DNA-dependent ATPase activity [Term] id: GO:0004004 name: ATP-dependent RNA helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, driving the unwinding of an RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0003724 ! RNA helicase activity is_a: GO:0008026 ! ATP-dependent helicase activity is_a: GO:0008186 ! RNA-dependent ATPase activity [Term] id: GO:0004005 name: plasma membrane cation-transporting ATPase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005886 consider: GO:0019829 [Term] id: GO:0004007 name: heavy metal-exporting ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: heavy metal ion(in) + ATP + H2O = heavy metal ion(out) + ADP + phosphate." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046873 [Term] id: GO:0004008 name: copper-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cu2+(in) = ADP + phosphate + Cu2+(out)." [EC:3.6.3.4] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cu2+-exporting)" EXACT [EC:3.6.3.4] synonym: "copper exporting ATPase activity" EXACT [] synonym: "copper-translocating P-type ATPase activity" RELATED [EC:3.6.3.4] synonym: "Cu(2+)-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "Cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] synonym: "cu2+-exporting ATPase activity" EXACT [EC:3.6.3.4] xref: EC:3.6.3.4 xref: MetaCyc:3.6.3.4-RXN is_a: GO:0043682 ! copper-transporting ATPase activity relationship: part_of GO:0060003 ! copper ion export [Term] id: GO:0004009 name: ATP-binding cassette (ABC) transporter activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because ABC transporters are a protein family rather than a functional grouping. is_obsolete: true consider: GO:0042626 consider: GO:0043190 [Term] id: GO:0004012 name: phospholipid-translocating ATPase activity namespace: molecular_function alt_id: GO:0008557 def: "Catalysis of the movement of phospholipids from one membrane face to the other (phospolipid 'flippase' activity), driven by the hydrolysis of ATP." [EC:3.6.3.1, PMID:15919184, PMID:9099684] subset: gosubset_prok synonym: "aminophospholipid-transporting ATPase" NARROW [] synonym: "ATP phosphohydrolase (phospholipid-flipping)" EXACT [EC:3.6.3.1] synonym: "flippase activity" BROAD [EC:3.6.3.1] synonym: "magnesium-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg(2+)-ATPase activity" RELATED [EC:3.6.3.1] synonym: "Mg2+-ATPase activity" EXACT [EC:3.6.3.1] synonym: "phospholipid translocating ATPase activity" EXACT [] synonym: "phospholipid-transporting ATPase activity" EXACT [EC:3.6.3.1] xref: EC:3.6.3.1 xref: MetaCyc:3.6.3.1-RXN is_a: GO:0005548 ! phospholipid transporter activity is_a: GO:0043492 ! ATPase activity, coupled to movement of substances [Term] id: GO:0004013 name: adenosylhomocysteinase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine." [EC:3.3.1.1] subset: gosubset_prok synonym: "adenosylhomocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "AdoHcyase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosyl-L-homocysteine hydrolase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteinase activity" EXACT [EC:3.3.1.1] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.3.1.1] synonym: "S-adenosylhomocysteine synthase activity" EXACT [EC:3.3.1.1] synonym: "SAHase activity" EXACT [EC:3.3.1.1] xref: EC:3.3.1.1 xref: MetaCyc:ADENOSYLHOMOCYSTEINASE-RXN xref: Reactome:7047 "adenosylhomocysteinase activity" is_a: GO:0016802 ! trialkylsulfonium hydrolase activity [Term] id: GO:0004014 name: adenosylmethionine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine = (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt + CO2." [EC:4.1.1.50] subset: gosubset_prok synonym: "adenosyl methionine decarboxylase activity" EXACT [] synonym: "S-adenosyl-L-methionine carboxy-lyase [(5-deoxy-5-adenosyl)(3-aminopropyl)-methylsulfonium-salt-forming]" RELATED [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine carboxy-lyase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosyl-L-methionine decarboxylase activity" EXACT [EC:4.1.1.50] synonym: "S-adenosylmethionine decarboxylase activity" EXACT [EC:4.1.1.50] xref: EC:4.1.1.50 xref: MetaCyc:SAMDECARB-RXN xref: Reactome:7049 "adenosylmethionine decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004015 name: adenosylmethionine-8-amino-7-oxononanoate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 8-amino-7-oxononanoate = S-adenosyl-4-methylthio-2-oxobutanoate + 7,8-diaminononanoate." [EC:2.6.1.62] subset: gosubset_prok synonym: "7,8-diamino-pelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminonanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminononanoate transaminase activity" EXACT [EC:2.6.1.62] synonym: "7,8-diaminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid" RELATED [EC:2.6.1.62] synonym: "7-keto-8-aminopelargonic acid aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosyl methionine-8-amino-7-oxononanoate transaminase activity" EXACT [] synonym: "adenosylmethionine--8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "adenosylmethionine-8-amino-7-oxononanoate aminotransferase activity" EXACT [] synonym: "DAPA aminotransferase activity" EXACT [EC:2.6.1.62] synonym: "DAPA transaminase activity" EXACT [EC:2.6.1.62] synonym: "diaminopelargonate synthase activity" EXACT [EC:2.6.1.62] synonym: "S-adenosyl-L-methionine:8-amino-7-oxononanoate aminotransferase activity" EXACT [EC:2.6.1.62] xref: EC:2.6.1.62 xref: MetaCyc:DAPASYN-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004016 name: adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate." [EC:4.6.1.1] subset: gosubset_prok synonym: "3',5'-cyclic AMP synthetase activity" EXACT [EC:4.6.1.1] synonym: "adenyl cyclase activity" EXACT [EC:4.6.1.1] synonym: "adenylyl cyclase activity" EXACT [] synonym: "adenylylcyclase activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.1] synonym: "ATP diphosphate-lyase (cyclizing; 3',5'-cyclic-AMP-forming) activity" EXACT [EC:4.6.1.1] synonym: "ATP pyrophosphate-lyase activity" EXACT [EC:4.6.1.1] synonym: "cAMP generating peptide activity" RELATED [] xref: EC:4.6.1.1 xref: MetaCyc:ADENYLATECYC-RXN xref: Reactome:7056 "adenylate cyclase activity" is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity relationship: part_of GO:0006171 ! cAMP biosynthetic process [Term] id: GO:0004017 name: adenylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + AMP = 2 ADP." [EC:2.7.4.3] subset: gosubset_prok synonym: "5'-AMP-kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylic kinase activity" EXACT [EC:2.7.4.3] synonym: "adenylokinase activity" EXACT [EC:2.7.4.3] synonym: "ATP:AMP phosphotransferase activity" EXACT [EC:2.7.4.3] synonym: "myokinase activity" NARROW [EC:2.7.4.3] xref: EC:2.7.4.3 xref: MetaCyc:ADENYL-KIN-RXN xref: Reactome:7059 "adenylate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004018 name: N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP." [EC:4.3.2.2] subset: gosubset_prok synonym: "6-N-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "adenylosuccinase activity" BROAD [EC:4.3.2.2, GOC:mah] synonym: "adenylosuccinate lyase activity" BROAD [GOC:mah] synonym: "N6-(1,2-dicarboxyethyl)AMP AMP-lyase activity" EXACT [EC:4.3.2.2] synonym: "succino AMP-lyase activity" BROAD [EC:4.3.2.2, GOC:mah] xref: EC:4.3.2.2 xref: KEGG:R01083 xref: MetaCyc:AMPSYN-RXN xref: Reactome:7065 "N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004019 name: adenylosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + IMP + L-aspartate = GDP + phosphate + N6-(1,2-dicarboxyethyl)-AMP." [EC:6.3.4.4] subset: gosubset_prok synonym: "adenylosuccinate synthetase activity" EXACT [EC:6.3.4.4] synonym: "IMP--aspartate ligase activity" EXACT [EC:6.3.4.4] synonym: "IMP:L-aspartate ligase (GDP-forming)" EXACT [EC:6.3.4.4] synonym: "succino-AMP synthetase activity" EXACT [EC:6.3.4.4] synonym: "succinoadenylic kinosynthetase activity" EXACT [EC:6.3.4.4] xref: EC:6.3.4.4 xref: MetaCyc:ADENYLOSUCCINATE-SYNTHASE-RXN xref: Reactome:7069 "adenylosuccinate synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004020 name: adenylylsulfate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + adenylylsulfate = ADP + 3'-phosphoadenosine 5'-phosphosulfate." [EC:2.7.1.25] subset: gosubset_prok synonym: "5'-phosphoadenosine sulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine 5'-phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfate kinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine phosphosulfokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulfate 3'-phosphotransferase activity" EXACT [] synonym: "adenosine-5'-phosphosulfate-3'-phosphokinase activity" EXACT [EC:2.7.1.25] synonym: "adenosine-5'-phosphosulphate 3'-phosphotransferase activity" EXACT [] synonym: "adenylyl-sulfate kinase activity" EXACT [] synonym: "adenylyl-sulphate kinase activity" EXACT [] synonym: "adenylylsulfate kinase (phosphorylating)" EXACT [EC:2.7.1.25] synonym: "APS kinase activity" EXACT [EC:2.7.1.25] synonym: "ATP:adenylyl-sulfate 3'-phosphotransferase activity" EXACT [EC:2.7.1.25] xref: EC:2.7.1.25 xref: MetaCyc:ADENYLYLSULFKIN-RXN xref: Reactome:7077 "adenylylsulfate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004021 name: L-alanine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + 2-oxoglutarate = pyruvate + L-glutamate." [EC:2.6.1.2] subset: gosubset_prok synonym: "alanine aminotransferase activity" BROAD [] synonym: "alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "alanine-pyruvate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "ALT" RELATED [EC:2.6.1.2] synonym: "beta-alanine aminotransferase" BROAD [EC:2.6.1.2] synonym: "glutamic acid-pyruvic acid transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--alanine transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic--pyruvic transaminase activity" EXACT [EC:2.6.1.2] synonym: "glutamic-pyruvic aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "GPT" RELATED [EC:2.6.1.2] synonym: "L-alanine aminotransferase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine transaminase activity" BROAD [EC:2.6.1.2] synonym: "L-alanine-alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate transaminase activity" BROAD [EC:2.6.1.2] synonym: "pyruvate-alanine aminotransferase activity" EXACT [EC:2.6.1.2] synonym: "pyruvate-glutamate transaminase activity" EXACT [EC:2.6.1.2] xref: EC:2.6.1.2 xref: MetaCyc:ALANINE-AMINOTRANSFERASE-RXN xref: Reactome:7079 "L-alanine:2-oxoglutarate aminotransferase activity" is_a: GO:0047635 ! alanine-oxo-acid transaminase activity [Term] id: GO:0004022 name: alcohol dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+." [EC:1.1.1.1] subset: gosubset_prok synonym: "ADH" RELATED [EC:1.1.1.1] synonym: "alcohol dehydrogenase activity" BROAD [GOC:mah] synonym: "alcohol:NAD+ oxidoreductase" EXACT [EC:1.1.1.1] synonym: "aliphatic alcohol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "ethanol dehydrogenase" NARROW [EC:1.1.1.1] synonym: "NAD-dependent alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NAD-specific aromatic alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-alcohol dehydrogenase" EXACT [EC:1.1.1.1] synonym: "NADH-aldehyde dehydrogenase" EXACT [EC:1.1.1.1] synonym: "primary alcohol dehydrogenase" BROAD [EC:1.1.1.1] synonym: "yeast alcohol dehydrogenase" NARROW [EC:1.1.1.1] xref: EC:1.1.1.1 xref: MetaCyc:ALCOHOL-DEHYDROG-GENERIC-RXN xref: UM-BBD_enzymeID:e0023 is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004023 name: alcohol dehydrogenase activity, metal ion-independent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+; can proceed in the absence of a metal ion." [EC:1.1.1.1, GOC:mah] is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004024 name: alcohol dehydrogenase activity, zinc-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+ requiring the presence of zinc." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok xref: Reactome:7085 "alcohol dehydrogenase activity, zinc-dependent" is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004025 name: alcohol dehydrogenase activity, iron-dependent namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+, requiring the presence of iron." [EC:1.1.1.1, GOC:mah] subset: gosubset_prok is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0004026 name: alcohol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alcohol = CoA + an acetyl ester." [EC:2.3.1.84] synonym: "AATASE activity" EXACT [EC:2.3.1.84] synonym: "acetyl-CoA:alcohol O-acetyltransferase activity" EXACT [EC:2.3.1.84] synonym: "alcohol acetyltransferase activity" EXACT [EC:2.3.1.84] xref: EC:2.3.1.84 xref: MetaCyc:ALCOHOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity is_a: GO:0034318 ! alcohol O-acyltransferase activity [Term] id: GO:0004027 name: alcohol sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + an alcohol = adenosine 3',5'-bisphosphate + an alkyl sulfate." [EC:2.8.2.2] subset: gosubset_prok synonym: "3'-phosphoadenylyl-sulfate:alcohol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxy steroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "3beta-hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "5alpha-androstenol sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "alcohol sulphotransferase activity" EXACT [] synonym: "alcohol/hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "dehydroepiandrosterone sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "delta5-3beta-hydroxysteroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.2] synonym: "HST" RELATED [EC:2.8.2.2] synonym: "hydroxysteroid sulfotransferase activity" EXACT [EC:2.8.2.2] synonym: "steroid alcohol sulfotransferase" BROAD [EC:2.8.2.2] synonym: "steroid sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfokinase activity" EXACT [EC:2.8.2.2] synonym: "sterol sulfotransferase activity" EXACT [EC:2.8.2.2] xref: EC:2.8.2.2 xref: MetaCyc:ALCOHOL-SULFOTRANSFERASE-RXN xref: Reactome:7092 "alcohol sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004028 name: 3-chloroallyl aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-chloroallyl aldehyde + H2O = 2 H+ + 2 e- + 3-chloroacrylic acid." [UM-BBD_enzymeID:e0432] subset: gosubset_prok xref: EC:1.2.1.- xref: Reactome:7095 "3-chloroallyl aldehyde dehydrogenase activity" xref: UM-BBD_enzymeID:e0432 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004029 name: aldehyde dehydrogenase (NAD) activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD+ + H2O = an acid + NADH + H+." [EC:1.2.1.3] subset: gosubset_prok synonym: "aldehyde dehydrogenase (NAD+)" EXACT [EC:1.2.1.3] synonym: "aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.3] synonym: "CoA-independent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "m-methylbenzaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent 4-hydroxynonenal dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-dependent aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "NAD-linked aldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] synonym: "propionaldehyde dehydrogenase activity" EXACT [EC:1.2.1.3] xref: EC:1.2.1.3 xref: MetaCyc:ALDHDEHYDROG-RXN xref: Reactome:7097 "aldehyde dehydrogenase (NAD) activity" xref: UM-BBD_enzymeID:e0024 xref: Wikipedia:Aldehyde_dehydrogenase_(NAD+) is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004030 name: aldehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+." [EC:1.2.1.5] subset: gosubset_prok synonym: "aldehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.5] synonym: "ALDH" RELATED [EC:1.2.1.5] xref: EC:1.2.1.5 xref: MetaCyc:ALDEHYDE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004031 name: aldehyde oxidase activity namespace: molecular_function def: "Catalysis of the reaction: an aldehyde + H2O + O2 = a carboxylic acid + H2O2." [EC:1.2.3.1] subset: gosubset_prok synonym: "aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.1] synonym: "quinoline oxidase activity" RELATED [EC:1.2.3.1] xref: EC:1.2.3.1 xref: MetaCyc:ALDEHYDE-OXIDASE-RXN is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004032 name: aldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: an alditol + NADP+ = an aldose + NADPH + H+." [EC:1.1.1.21] subset: gosubset_prok synonym: "aldose reductase activity" EXACT [EC:1.1.1.21] synonym: "polyol dehydrogenase (NADP(+)) activity" RELATED [EC:1.1.1.21] xref: EC:1.1.1.21 xref: MetaCyc:ALDEHYDE-REDUCTASE-RXN xref: Reactome:7111 "aldehyde reductase activity" is_a: GO:0004033 ! aldo-keto reductase activity [Term] id: GO:0004033 name: aldo-keto reductase activity namespace: molecular_function def: "Catalysis of the NADPH-dependent reduction of carbonyl compounds." [GOC:jl, PMID:2498333] subset: gosubset_prok synonym: "NADPH-dependent aldo-keto reductase activity" EXACT [GOC:vw] xref: EC:1.1.1.- xref: Reactome:7114 "aldo-keto reductase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004034 name: aldose 1-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose = beta-D-glucose. Also acts on L-arabinose, D-xylose, D-galactose, maltose and lactose." [EC:5.1.3.3] subset: gosubset_prok synonym: "aldose mutarotase activity" RELATED [EC:5.1.3.3] synonym: "mutarotase activity" RELATED [EC:5.1.3.3] xref: EC:5.1.3.3 xref: MetaCyc:ALDOSE-1-EPIMERASE-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004035 name: alkaline phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum." [EC:3.1.3.1] subset: gosubset_prok synonym: "alkaline phenyl phosphatase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphohydrolase activity" EXACT [EC:3.1.3.1] synonym: "alkaline phosphomonoesterase activity" EXACT [EC:3.1.3.1] synonym: "glycerophosphatase activity" BROAD [EC:3.1.3.1] synonym: "orthophosphoric-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphate-monoester phosphohydrolase (alkaline optimum)" EXACT [EC:3.1.3.1] synonym: "phosphomonoesterase activity" BROAD [EC:3.1.3.1] xref: EC:3.1.3.1 xref: MetaCyc:ALKAPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004037 name: allantoicase activity namespace: molecular_function def: "Catalysis of the reaction: allantoate + H2O = (-)-ureidoglycolate + urea." [EC:3.5.3.4] subset: gosubset_prok synonym: "allantoate amidinohydrolase activity" EXACT [EC:3.5.3.4] synonym: "allantoine amidinohydrolase activity" EXACT [] xref: EC:3.5.3.4 xref: MetaCyc:ALLANTOICASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004038 name: allantoinase activity namespace: molecular_function def: "Catalysis of the reaction: allantoin + H2O = allantoate." [EC:3.5.2.5] subset: gosubset_prok synonym: "(S)-allantoin amidohydrolase activity" EXACT [EC:3.5.2.5] xref: EC:3.5.2.5 xref: MetaCyc:ALLANTOINASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004039 name: allophanate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: urea-1-carboxylate + H2O = 2 CO2 + 2 NH3." [EC:3.5.1.54] subset: gosubset_prok synonym: "allophanate lyase activity" EXACT [EC:3.5.1.54] synonym: "urea-1-carboxylate amidohydrolase activity" EXACT [EC:3.5.1.54] xref: EC:3.5.1.54 xref: MetaCyc:ALLOPHANATE-HYDROLASE-RXN xref: UM-BBD_enzymeID:e0534 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004040 name: amidase activity namespace: molecular_function def: "Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH3." [EC:3.5.1.4] subset: gosubset_prok synonym: "acetamidase activity" EXACT [] synonym: "acylamidase activity" EXACT [EC:3.5.1.4] synonym: "acylamide amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "acylase activity" EXACT [EC:3.5.1.4] synonym: "amidohydrolase activity" EXACT [EC:3.5.1.4] synonym: "fatty acylamidase activity" EXACT [EC:3.5.1.4] synonym: "N-acetylaminohydrolase activity" EXACT [EC:3.5.1.4] xref: EC:3.5.1.4 xref: MetaCyc:AMIDASE-RXN xref: UM-BBD_enzymeID:e0068 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004042 name: acetyl-CoA:L-glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-glutamate = CoA + N-acetyl-L-glutamate." [EC:2.3.1.1] subset: gosubset_prok synonym: "acetylglutamate acetylglutamate synthetase activity" EXACT [EC:2.3.1.1] synonym: "AGAS" RELATED [EC:2.3.1.1] synonym: "amino acid acetyltransferase activity" EXACT [EC:2.3.1.1] synonym: "amino-acid N-acetyltransferase activity" BROAD [EC:2.3.1.1] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.1] xref: EC:2.3.1.1 xref: MetaCyc:N-ACETYLTRANSFER-RXN xref: Reactome:7143 "acetyl-CoA:L-glutamate N-acetyltransferase activity" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004043 name: L-aminoadipate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-2-aminoadipate 6-semialdehyde + NADP+ + H2O = L-2-aminoadipate + NADPH + H+." [EC:1.2.1.31] subset: gosubset_prok synonym: "2-aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "2-aminoadipic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "AAR" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate reductase activity" EXACT [EC:1.2.1.31] synonym: "alpha-aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "aminoadipate-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.31] synonym: "L-2-aminoadipate-6-semialdehyde:NAD(P)+ 6-oxidoreductase" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.31] synonym: "L-alpha-aminoadipate delta-semialdehyde:nicotinamide adenine dinucleotide oxidoreductase activity" EXACT [EC:1.2.1.31] xref: EC:1.2.1.31 xref: MetaCyc:1.2.1.31-RXN xref: Reactome:7145 "L-aminoadipate-semialdehyde dehydrogenase activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004044 name: amidophosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phospho-beta-D-ribosylamine + diphosphate + L-glutamate = L-glutamine + 5-phospho-alpha-D-ribose 1-diphosphate + H2O." [EC:2.4.2.14] subset: gosubset_prok synonym: "5'-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "5-phosphoribosylamine:diphosphate phospho-alpha-D-ribosyltransferase (glutamate-amidating)" EXACT [EC:2.4.2.14] synonym: "5-phosphororibosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "alpha-5-phosphoribosyl-1-pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine 5-phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosyldiphosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine phosphoribosylpyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "glutamine ribosylpyrophosphate 5-phosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribose pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyl pyrophosphate amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosyldiphosphate 5-amidotransferase activity" EXACT [EC:2.4.2.14] synonym: "phosphoribosylpyrophosphate glutamyl amidotransferase activity" EXACT [EC:2.4.2.14] xref: EC:2.4.2.14 xref: MetaCyc:PRPPAMIDOTRANS-RXN xref: Reactome:7147 "amidophosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004045 name: aminoacyl-tRNA hydrolase activity namespace: molecular_function alt_id: GO:0019850 alt_id: GO:0019851 def: "Catalysis of the reaction: N-substituted aminoacyl-tRNA + H2O = N-substituted amino acid + tRNA." [EC:3.1.1.29] subset: gosubset_prok synonym: "aminoacyl-transfer ribonucleate hydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA aminoacylhydrolase activity" EXACT [EC:3.1.1.29] synonym: "aminoacyl-tRNA hydrolase reaction" EXACT [] synonym: "D-tyrosyl-tRNA hydrolase activity" NARROW [PMID:15292242] synonym: "N-substituted aminoacyl transfer RNA hydrolase activity" EXACT [EC:3.1.1.29] synonym: "peptidyl-tRNA hydrolase activity" EXACT [EC:3.1.1.29] xref: EC:3.1.1.29 xref: MetaCyc:AMINOCYL-TRNA-HYDROLASE-RXN is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004046 name: aminoacylase activity namespace: molecular_function def: "Catalysis of the reaction: an N-acyl-L-amino acid + H2O = a carboxylate + an L-amino acid." [EC:3.5.1.14] subset: gosubset_prok synonym: "acylase I activity" NARROW [EC:3.5.1.14] synonym: "alpha-N-acylaminoacid hydrolase activity" EXACT [EC:3.5.1.14] synonym: "amido acid deacylase activity" EXACT [EC:3.5.1.14] synonym: "aminoacylase I activity" NARROW [EC:3.5.1.14] synonym: "benzamidase activity" RELATED [EC:3.5.1.14] synonym: "dehydropeptidase II activity" NARROW [EC:3.5.1.14] synonym: "hippurase activity" EXACT [EC:3.5.1.14] synonym: "histozyme activity" RELATED [EC:3.5.1.14] synonym: "L-amino-acid acylase activity" EXACT [EC:3.5.1.14] synonym: "L-aminoacylase activity" EXACT [EC:3.5.1.14] synonym: "long acyl amidoacylase activity" EXACT [EC:3.5.1.14] synonym: "N-acyl-L-amino-acid amidohydrolase activity" EXACT [EC:3.5.1.14] synonym: "short acyl amidoacylase activity" EXACT [EC:3.5.1.14] xref: EC:3.5.1.14 xref: MetaCyc:AMINOACYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004047 name: aminomethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (6S)-tetrahydrofolate + S-aminomethyldihydrolipoylprotein = (6R)-5,10-methylenetetrahydrofolate + NH3 + dihydrolipoylprotein." [EC:2.1.2.10] subset: gosubset_prok synonym: "glycine synthase activity" RELATED [EC:2.1.2.10] synonym: "glycine-cleavage system T-protein activity" RELATED [EC:2.1.2.10] synonym: "protein-8-S-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "protein-S8-aminomethyldihydrolipoyllysine:tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "S-aminomethyldihydrolipoylprotein:(6S)-tetrahydrofolate aminomethyltransferase (ammonia-forming) activity" EXACT [EC:2.1.2.10] synonym: "T-protein" RELATED [EC:2.1.2.10] synonym: "tetrahydrofolate aminomethyltransferase activity" EXACT [EC:2.1.2.10] xref: EC:2.1.2.10 xref: MetaCyc:GCVT-RXN is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004048 name: anthranilate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-D-ribosyl)-anthranilate + diphosphate = anthranilate + 5-phospho-a-D-ribose 1-diphosphate." [EC:2.4.2.18] subset: gosubset_prok synonym: "anthranilate 5-phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate phosphoribosylpyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "anthranilate-PP-ribose-P phosphoribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "N-(5-phospho-D-ribosyl)-anthranilate:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate diphosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosyl-anthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate pyrophosphorylase activity" EXACT [EC:2.4.2.18] synonym: "phosphoribosylanthranilate transferase activity" EXACT [EC:2.4.2.18] synonym: "PRT" RELATED [EC:2.4.2.18] xref: EC:2.4.2.18 xref: MetaCyc:PRTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004049 name: anthranilate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate." [EC:4.1.3.27] subset: gosubset_prok synonym: "anthranilate synthetase activity" EXACT [EC:4.1.3.27] synonym: "chorismate pyruvate-lyase (amino-accepting) activity" EXACT [EC:4.1.3.27] xref: EC:4.1.3.27 xref: MetaCyc:ANTHRANSYN-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004050 name: apyrase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + 2 H2O = AMP + 2 phosphate." [EC:3.6.1.5, MetaCyc:APYRASE-RXN] comment: This term was made obsolete because it represents a gene product which can catalyze two reactions. is_obsolete: true consider: GO:0017110 consider: GO:0017111 [Term] id: GO:0004051 name: arachidonate 5-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (6E,8Z,11Z,14Z)-(5S)-5-hydroperoxycosa-6,8,11,14-tetraenoate." [EC:1.13.11.34] subset: gosubset_prok synonym: "5-delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "5Delta-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonate:oxygen 5-oxidoreductase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "arachidonic acid 5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "C-5-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta(5)-lipoxygenase activity" RELATED [EC:1.13.11.34] synonym: "delta5-lipoxygenase activity" EXACT [EC:1.13.11.34] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.34] synonym: "leukotriene-A(4) synthase activity" NARROW [EC:1.13.11.34] synonym: "leukotriene-A4 synthase activity" EXACT [EC:1.13.11.34] synonym: "LTA synthase activity" NARROW [EC:1.13.11.34] xref: EC:1.13.11.34 xref: MetaCyc:ARACHIDONATE-5-LIPOXYGENASE-RXN xref: Reactome:7163 "arachidonate 5-lipoxygenase activity" is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004052 name: arachidonate 12-lipoxygenase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + O2 = (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate." [EC:1.13.11.31] synonym: "12-lipoxygenase activity" RELATED [EC:1.13.11.31] synonym: "12Delta-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "12S-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "arachidonate:oxygen 12-oxidoreductase activity" EXACT [EC:1.13.11.31] synonym: "C-12 lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "delta12-lipoxygenase activity" EXACT [EC:1.13.11.31] synonym: "leukotriene A4 synthase" BROAD [EC:1.13.11.31] synonym: "LTA4 synthase activity" EXACT [EC:1.13.11.31] xref: EC:1.13.11.31 xref: MetaCyc:ARACHIDONATE-12-LIPOXYGENASE-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004053 name: arginase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + H2O = L-ornithine + urea." [EC:3.5.3.1] subset: gosubset_prok synonym: "arginine amidinase activity" EXACT [EC:3.5.3.1] synonym: "arginine transamidinase activity" EXACT [EC:3.5.3.1] synonym: "canavanase activity" EXACT [EC:3.5.3.1] synonym: "L-arginase activity" EXACT [EC:3.5.3.1] synonym: "L-arginine amidinohydrolase activity" EXACT [EC:3.5.3.1] xref: EC:3.5.3.1 xref: MetaCyc:ARGINASE-RXN xref: Reactome:7167 "arginase activity" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004054 name: arginine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine = ADP + N-phospho-L-arginine." [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate-arginine phosphotransferase activity" EXACT [EC:2.7.3.3] synonym: "adenosine 5'-triphosphate:L-arginine" RELATED [EC:2.7.3.3] synonym: "arginine phosphokinase activity" EXACT [EC:2.7.3.3] synonym: "ATP:L-arginine N-phosphotransferase activity" EXACT [EC:2.7.3.3] xref: EC:2.7.3.3 xref: MetaCyc:ARGININE-KINASE-RXN is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004055 name: argininosuccinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-citrulline + L-aspartate = AMP + diphosphate + (N(omega)-L-arginino)succinate." [EC:6.3.4.5] subset: gosubset_prok synonym: "arginine succinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "argininosuccinic acid synthetase activity" EXACT [EC:6.3.4.5] synonym: "arginosuccinate synthetase activity" EXACT [EC:6.3.4.5] synonym: "citrulline--aspartate ligase activity" EXACT [EC:6.3.4.5] synonym: "L-citrulline:L-aspartate ligase (AMP-forming)" EXACT [EC:6.3.4.5] xref: EC:6.3.4.5 xref: MetaCyc:ARGSUCCINSYN-RXN xref: Reactome:7171 "argininosuccinate synthase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004056 name: argininosuccinate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-(L-arginino)succinate = fumarate + L-arginine." [EC:4.3.2.1] subset: gosubset_prok synonym: "2-(Nomega-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "2-(omega-N-L-arginino)succinate arginine-lyase (fumarate-forming)" EXACT [EC:4.3.2.1] synonym: "arginine-succinate lyase activity" EXACT [EC:4.3.2.1] synonym: "argininosuccinic acid lyase activity" EXACT [EC:4.3.2.1] synonym: "arginosuccinase activity" EXACT [EC:4.3.2.1] synonym: "N-(L-argininosuccinate) arginine-lyase activity" EXACT [EC:4.3.2.1] synonym: "omega-N-(L-arginino)succinate arginine-lyase activity" EXACT [EC:4.3.2.1] xref: EC:4.3.2.1 xref: MetaCyc:ARGSUCCINLYA-RXN xref: Reactome:7173 "argininosuccinate lyase activity" is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004057 name: arginyltransferase activity namespace: molecular_function alt_id: GO:0042172 def: "Catalysis of the reaction: L-arginyl-tRNA + protein = tRNA + L-arginyl-protein." [EC:2.3.2.8] subset: gosubset_prok synonym: "arginine transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.8] synonym: "arginyl-tRNA-protein transferase activity" EXACT [] synonym: "L-arginyl-tRNA:protein arginyltransferase activity" EXACT [EC:2.3.2.8] xref: EC:2.3.2.8 xref: MetaCyc:ARGINYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0004058 name: aromatic-L-amino-acid decarboxylase activity namespace: molecular_function alt_id: GO:0016400 def: "Catalysis of the reaction: L-tryptophan = tryptamine + CO2." [EC:4.1.1.28] synonym: "5-hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic amino acid decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase (tryptamine-forming)" EXACT [EC:4.1.1.28] synonym: "aromatic-L-amino-acid carboxy-lyase activity" EXACT [EC:4.1.1.28] synonym: "DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "hydroxytryptophan decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "L-DOPA decarboxylase activity" EXACT [EC:4.1.1.28] synonym: "tryptophan decarboxylase activity" EXACT [EC:4.1.1.28] xref: EC:4.1.1.28 xref: MetaCyc:AROMATIC-L-AMINO-ACID-DECARBOXYLASE-RXN xref: Reactome:7178 "aromatic-L-amino-acid decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004059 name: aralkylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an aralkylamine = CoA + an N-acetylaralkylamine." [EC:2.3.1.87] synonym: "AANAT activity" EXACT [EC:2.3.1.87] synonym: "acetyl-CoA:2-arylethylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "arylalkylamine N-acetyltransferase activity" EXACT [EC:2.3.1.87] synonym: "melatonin rhythm enzyme activity" RELATED [EC:2.3.1.87] synonym: "serotonin acetylase activity" NARROW [EC:2.3.1.87] synonym: "serotonin acetyltransferase activity" NARROW [EC:2.3.1.87] synonym: "serotonin N-acetyltransferase activity" NARROW [EC:2.3.1.87] xref: EC:2.3.1.87 xref: MetaCyc:ARALKYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:7181 "aralkylamine N-acetyltransferase activity" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004060 name: arylamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an arylamine = CoA + an N-acetylarylamine." [EC:2.3.1.5] subset: gosubset_prok synonym: "2-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "4-aminobiphenyl N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl CoA-arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "acetyl-CoA:arylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetylase activity" EXACT [EC:2.3.1.5] synonym: "arylamine acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "beta-naphthylamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "indoleamine N-acetyltransferase activity" EXACT [EC:2.3.1.5] synonym: "p-aminosalicylate N-acetyltransferase activity" EXACT [EC:2.3.1.5] xref: EC:2.3.1.5 xref: MetaCyc:ARYLAMINE-N-ACETYLTRANSFERASE-RXN xref: Reactome:7187 "arylamine N-acetyltransferase activity" xref: UM-BBD_enzymeID:e0341 is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004061 name: arylformamidase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-kynurenine + H2O = formate + L-kynurenine." [EC:3.5.1.9] subset: gosubset_prok synonym: "aryl-formylamine amidohydrolase activity" EXACT [EC:3.5.1.9] synonym: "formamidase I" RELATED [EC:3.5.1.9] synonym: "formamidase II" RELATED [EC:3.5.1.9] synonym: "formylase activity" EXACT [EC:3.5.1.9] synonym: "formylkynureninase activity" EXACT [EC:3.5.1.9] synonym: "formylkynurenine formamidase activity" EXACT [EC:3.5.1.9] synonym: "kynurenine formamidase activity" EXACT [EC:3.5.1.9] xref: EC:3.5.1.9 xref: MetaCyc:ARYLFORMAMIDASE-RXN xref: Reactome:7190 "arylformamidase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004062 name: aryl sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + a phenol = adenosine 3',5'-bisphosphate + an aryl sulfate." [EC:2.8.2.1] subset: gosubset_prok synonym: "1-naphthol phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "2-naphtholsulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "3'-phosphoadenylyl-sulfate:phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "4-nitrocatechol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "aryl sulphotransferase activity" EXACT [] synonym: "arylsulfotransferase" BROAD [EC:2.8.2.1] synonym: "dopamine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "p-nitrophenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfokinase activity" EXACT [EC:2.8.2.1] synonym: "phenol sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "PST" RELATED [EC:2.8.2.1] synonym: "ritodrine sulfotransferase activity" EXACT [EC:2.8.2.1] synonym: "sulfokinase activity" RELATED [EC:2.8.2.1] xref: EC:2.8.2.1 xref: MetaCyc:ARYL-SULFOTRANSFERASE-RXN xref: Reactome:7193 "aryl sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004063 name: aryldialkylphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: aryl dialkyl phosphate + H2O = dialkyl phosphate + an aryl alcohol." [EC:3.1.8.1] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.8.1] synonym: "aryltriphosphatase activity" EXACT [EC:3.1.8.1] synonym: "aryltriphosphate dialkylphosphohydrolase activity" EXACT [EC:3.1.8.1] synonym: "esterase B1" RELATED [EC:3.1.8.1] synonym: "esterase E4" RELATED [EC:3.1.8.1] synonym: "OPH" RELATED [EC:3.1.8.1] synonym: "organophosphate esterase activity" EXACT [EC:3.1.8.1] synonym: "organophosphate hydrolase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus acid anhydrase activity" EXACT [EC:3.1.8.1] synonym: "organophosphorus hydrolase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon esterase activity" EXACT [EC:3.1.8.1] synonym: "paraoxon hydrolase activity" BROAD [EC:3.1.8.1] synonym: "paraoxonase activity" BROAD [EC:3.1.8.1] synonym: "phosphotriesterase activity" EXACT [EC:3.1.8.1] synonym: "pirimiphos-methyloxon esterase activity" EXACT [EC:3.1.8.1] xref: EC:3.1.8.1 xref: MetaCyc:ARYLDIALKYLPHOSPHATASE-RXN xref: UM-BBD_enzymeID:e0054 is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004064 name: arylesterase activity namespace: molecular_function def: "Catalysis of the reaction: a phenyl acetate + H2O = a phenol + acetate." [EC:3.1.1.2] subset: gosubset_prok synonym: "A-esterase activity" BROAD [EC:3.1.1.2] synonym: "aromatic esterase" NARROW [EC:3.1.1.2] synonym: "aryl-ester hydrolase" NARROW [EC:3.1.1.2] synonym: "paraoxonase activity" BROAD [EC:3.1.1.2] xref: EC:3.1.1.2 xref: MetaCyc:ARYLESTERASE-RXN xref: UM-BBD_enzymeID:e0535 is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004065 name: arylsulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a phenol sulfate + H2O = a phenol + SO4(2-) (sulfate)." [EC:3.1.6.1] subset: gosubset_prok synonym: "4-methylumbelliferyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulfate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "aryl-sulphate sulphohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulfohydrolase activity" EXACT [EC:3.1.6.1] synonym: "arylsulphatase activity" EXACT [] synonym: "estrogen sulfatase activity" EXACT [EC:3.1.6.1] synonym: "nitrocatechol sulfatase activity" EXACT [EC:3.1.6.1] synonym: "p-nitrophenyl sulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenolsulfatase activity" EXACT [EC:3.1.6.1] synonym: "phenylsulfatase activity" EXACT [EC:3.1.6.1] synonym: "sulfatase activity" RELATED [EC:3.1.6.1] xref: EC:3.1.6.1 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004066 name: asparagine synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate." [EC:6.3.5.4] subset: gosubset_prok synonym: "AS" RELATED [EC:6.3.5.4] synonym: "AS-B activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolysing)" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.4] synonym: "asparagine synthetase B activity" EXACT [EC:6.3.5.4] synonym: "glutamine-dependent asparagine synthetase activity" EXACT [EC:6.3.5.4] synonym: "L-aspartate:L-glutamine amido-ligase (AMP-forming)" EXACT [EC:6.3.5.4] xref: EC:6.3.5.4 xref: MetaCyc:ASNSYNB-RXN xref: Reactome:7213 "asparagine synthase (glutamine-hydrolyzing) activity" is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004067 name: asparaginase activity namespace: molecular_function def: "Catalysis of the reaction: L-asparagine + H2O = L-aspartate + NH3." [EC:3.5.1.1] subset: gosubset_prok synonym: "alpha-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "asparaginase II" RELATED [EC:3.5.1.1] synonym: "colaspase activity" EXACT [EC:3.5.1.1] synonym: "crasnitin" RELATED [EC:3.5.1.1] synonym: "elspar" RELATED [EC:3.5.1.1] synonym: "L-asparaginase activity" EXACT [EC:3.5.1.1] synonym: "L-asparagine amidohydrolase activity" EXACT [EC:3.5.1.1] synonym: "leunase activity" EXACT [EC:3.5.1.1] xref: EC:3.5.1.1 xref: MetaCyc:ASPARAGHYD-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004068 name: aspartate 1-decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = beta-alanine + CO2." [EC:4.1.1.11] subset: gosubset_prok synonym: "aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase (beta-alanine-forming)" EXACT [EC:4.1.1.11] synonym: "L-aspartate 1-carboxy-lyase activity" EXACT [EC:4.1.1.11] synonym: "L-aspartate alpha-decarboxylase activity" EXACT [EC:4.1.1.11] xref: EC:4.1.1.11 xref: MetaCyc:ASPDECARBOX-RXN xref: MetaCyc:PWY-5155 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004069 name: L-aspartate:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + 2-oxoglutarate = oxaloacetate + L-glutamate." [EC:2.6.1.1] subset: gosubset_prok synonym: "2-oxoglutarate-glutamate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "AAT" RELATED [EC:2.6.1.1] synonym: "aspartate alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate aminotransferase activity" BROAD [] synonym: "aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "aspartate-2-oxoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "aspartate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "aspartic acid aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "aspartyl aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "AspT" RELATED [EC:2.6.1.1] synonym: "glutamate oxaloacetate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalacetate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamate-oxalate transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic oxalic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--aspartic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic--oxaloacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-aspartic aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "glutamic-oxalacetic transaminase activity" EXACT [EC:2.6.1.1] synonym: "GOT (enzyme)" RELATED [EC:2.6.1.1] synonym: "L-aspartate transaminase activity" BROAD [EC:2.6.1.1] synonym: "L-aspartate-2-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-2-oxoglutarate-transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartate-alpha-ketoglutarate transaminase activity" EXACT [EC:2.6.1.1] synonym: "L-aspartic aminotransferase activity" BROAD [EC:2.6.1.1] synonym: "oxaloacetate transferase activity" EXACT [EC:2.6.1.1] synonym: "oxaloacetate-aspartate aminotransferase activity" EXACT [EC:2.6.1.1] synonym: "transaminase A activity" RELATED [EC:2.6.1.1] xref: EC:2.6.1.1 xref: MetaCyc:ASPAMINOTRANS-RXN xref: Reactome:7220 "L-aspartate:2-oxoglutarate aminotransferase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004070 name: aspartate carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-aspartate = phosphate + N-carbamoyl-L-aspartate." [EC:2.1.3.2] subset: gosubset_prok synonym: "aspartate carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic acid transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "aspartic carbamyltransferase activity" EXACT [EC:2.1.3.2] synonym: "aspartic transcarbamylase activity" EXACT [EC:2.1.3.2] synonym: "ATCase activity" EXACT [EC:2.1.3.2] synonym: "carbamoyl-phosphate:L-aspartate carbamoyltransferase activity" EXACT [EC:2.1.3.2] synonym: "carbamoylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "carbamylaspartotranskinase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamoylase activity" EXACT [EC:2.1.3.2] synonym: "L-aspartate transcarbamylase activity" EXACT [EC:2.1.3.2] xref: EC:2.1.3.2 xref: MetaCyc:ASPCARBTRANS-RXN xref: Reactome:7225 "aspartate carbamoyltransferase activity" is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity [Term] id: GO:0004071 name: aspartate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + NH3 = AMP + diphosphate + L-asparagine." [EC:6.3.1.1] subset: gosubset_prok synonym: "asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-asparagine synthetase activity" EXACT [EC:6.3.1.1] synonym: "L-aspartate:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.1] xref: EC:6.3.1.1 xref: MetaCyc:ASNSYNA-RXN is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004072 name: aspartate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate = ADP + 4-phospho-L-aspartate." [EC:2.7.2.4] subset: gosubset_prok synonym: "aspartic kinase activity" EXACT [EC:2.7.2.4] synonym: "aspartokinase activity" EXACT [EC:2.7.2.4] synonym: "ATP:L-aspartate 4-phosphotransferase activity" EXACT [EC:2.7.2.4] synonym: "beta-aspartokinase activity" EXACT [EC:2.7.2.4] xref: EC:2.7.2.4 xref: MetaCyc:ASPARTATEKIN-RXN is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004073 name: aspartate-semialdehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + phosphate + NADP+ = L-4-aspartyl phosphate + NADPH + H+." [EC:1.2.1.11] subset: gosubset_prok synonym: "ASA dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "aspartic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-4-semialdehyde:NADP+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.11] synonym: "L-aspartate-beta-semialdehyde:NADP oxidoreductase (phosporylating)" EXACT [EC:1.2.1.11] xref: EC:1.2.1.11 xref: MetaCyc:ASPARTATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004074 name: biliverdin reductase activity namespace: molecular_function def: "Catalysis of the reaction: bilirubin + NAD(P)+ = biliverdin + NAD(P)H + H+." [EC:1.3.1.24] synonym: "bilirubin:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.24] xref: EC:1.3.1.24 xref: MetaCyc:BILIVERDIN-REDUCTASE-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004075 name: biotin carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin-carboxyl-carrier protein + CO2 = ADP + phosphate + carboxybiotin-carboxyl-carrier protein." [EC:6.3.4.14] subset: gosubset_prok synonym: "biotin carboxylase (component of acetyl CoA carboxylase) activity" EXACT [EC:6.3.4.14] synonym: "biotin-carboxyl-carrier-protein:carbon-dioxide ligase (ADP-forming) activity" EXACT [EC:6.3.4.14] xref: EC:6.3.4.14 xref: MetaCyc:BIOTIN-CARBOXYL-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004076 name: biotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: dethiobiotin + sulfur = biotin." [EC:2.8.1.6, PMID:18307109] subset: gosubset_prok synonym: "biotin synthetase activity" EXACT [EC:2.8.1.6] synonym: "dethiobiotin:sulfur sulfurtransferase activity" EXACT [EC:2.8.1.6] xref: EC:2.8.1.6 xref: MetaCyc:2.8.1.6-RXN is_a: GO:0016783 ! sulfurtransferase activity is_a: GO:0070283 ! radical SAM enzyme activity [Term] id: GO:0004077 name: biotin-[acetyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(acetyl-CoA:carbon-dioxide ligase (ADP forming)) = AMP + diphosphate + (acetyl-CoA:carbon-dioxide ligase (ADP forming))." [EC:6.3.4.15] subset: gosubset_prok synonym: "acetyl CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "acetyl-CoA carboxylase biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin holoenzyme synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--[acetyl-CoA carboxylase] synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin--protein ligase activity" RELATED [EC:6.3.4.15] synonym: "biotin-acetyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.15] synonym: "biotin-acetyl-CoA carboxylase synthetase" BROAD [EC:6.3.4.15] synonym: "biotin-acetyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "biotin:apo-acetyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.15] synonym: "biotin:apocarboxylase ligase activity" EXACT [EC:6.3.4.15] synonym: "HCS" RELATED [EC:6.3.4.15] xref: EC:6.3.4.15 xref: MetaCyc:BIOTINLIG-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004078 name: biotin-[methylcrotonoyl-CoA-carboxylase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.11] synonym: "beta-methylcrotonyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin--[methylcrotonoyl-CoA-carboxylase] synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-beta-methylcrotonyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase ligase activity" EXACT [EC:6.3.4.11] synonym: "biotin-methylcrotonoyl-CoA-carboxylase synthetase" BROAD [EC:6.3.4.11] synonym: "biotin:apo-3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.11] synonym: "holocarboxylase-synthetase activity" EXACT [EC:6.3.4.11] xref: EC:6.3.4.11 xref: MetaCyc:6.3.4.11-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004079 name: biotin-[methylmalonyl-CoA-carboxytransferase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(methylmalonyl-CoA:pyruvate carboxytransferase) = AMP + diphosphate + (methylmalonyl-CoA:pyruvate carboxytransferase)." [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxyltransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin--[methylmalonyl-CoA-carboxytransferase] synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-[methylmalonyl-CoA-carboxyltransferase] ligase activity" EXACT [] synonym: "biotin-methylmalonyl coenzyme A carboxyltransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxyltransferase synthetase" BROAD [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase ligase activity" EXACT [EC:6.3.4.9] synonym: "biotin-methylmalonyl-CoA-carboxytransferase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin-transcarboxylase synthetase activity" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxyltransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "biotin:apomethylmalonyl-CoA:pyruvate carboxytransferase ligase (AMP-forming)" EXACT [EC:6.3.4.9] synonym: "methylmalonyl coenzyme A holotranscarboxylase synthetase activity" EXACT [EC:6.3.4.9] xref: EC:6.3.4.9 xref: MetaCyc:6.3.4.9-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004080 name: biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + biotin + apo-(propanoyl-CoA:carbon-dioxide ligase (ADP-forming)) = AMP + diphosphate + (propanoyl-CoA:carbon-dioxide ligase (ADP-forming))." [EC:6.3.4.10] synonym: "biotin-[propionyl-CoA-carboxylase (ATP-hydrolyzing)] synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl coenzyme A carboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) ligase activity" EXACT [EC:6.3.4.10] synonym: "biotin-propionyl-CoA-carboxylase (ATP-hydrolysing) synthetase activity" EXACT [EC:6.3.4.10] synonym: "biotin:apo-propanoyl-CoA:carbon-dioxide ligase (ADP-forming) ligase (AMP-forming)" EXACT [EC:6.3.4.10] synonym: "holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl coenzyme A holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] synonym: "propionyl-CoA holocarboxylase synthetase activity" EXACT [EC:6.3.4.10] xref: EC:6.3.4.10 xref: MetaCyc:6.3.4.10-RXN is_a: GO:0018271 ! biotin-protein ligase activity [Term] id: GO:0004081 name: bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = NTP + NMP. Acts on bis(5'-guanosyl)-, bis(5'-xanthosyl)-, bis(5'-adenosyl)- and bis(5'-uridyl)-tetraphosphate." [EC:3.6.1.17, PMID:4955726] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap(4)Aase activity" BROAD [EC:3.6.1.17] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.17] synonym: "Ap4Aase activity" BROAD [EC:3.6.1.17] synonym: "bis(5'-adenosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "bis(5'-guanosyl)-tetraphosphatase activity" NARROW [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase activity" EXACT [EC:3.6.1.17] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate hydrolase" NARROW [] synonym: "diadenosine P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "diadenosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "diguanosinetetraphosphatase (asymmetrical) activity" NARROW [EC:3.6.1.17] synonym: "dinucleoside tetraphosphatase activity" EXACT [EC:3.6.1.17] synonym: "dinucleosidetetraphosphatase (asymmetrical) activity" EXACT [EC:3.6.1.17] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.17] xref: EC:3.6.1.17 xref: MetaCyc:3.6.1.17-RXN is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0004082 name: bisphosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phospho-D-glyceroyl phosphate = 2,3-bisphospho-D-glycerate." [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "2,3-diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "3-phospho-D-glycerate 1,2-phosphomutase activity" EXACT [EC:5.4.2.4] synonym: "biphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglycerate synthase activity" EXACT [EC:5.4.2.4] synonym: "bisphosphoglyceromutase" BROAD [EC:5.4.2.4] synonym: "BPGM activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglycerate mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceric mutase activity" EXACT [EC:5.4.2.4] synonym: "diphosphoglyceromutase activity" EXACT [EC:5.4.2.4] synonym: "DPGM" RELATED [EC:5.4.2.4] synonym: "glycerate phosphomutase activity" EXACT [EC:5.4.2.4] xref: EC:5.4.2.4 xref: MetaCyc:BISPHOSPHOGLYCERATE-MUTASE-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004083 name: 2,3-bisphospho-D-glycerate 2-phosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diphosphoglycerate + H2O = 3-phosphoglycerate + phosphate." [EC:3.1.3.13] synonym: "bisphosphoglycerate 2-phosphatase activity" BROAD [EC:3.1.3.13] xref: EC:3.1.3.13 xref: MetaCyc:BISPHOSPHOGLYCERATE-PHOSPHATASE-RXN is_a: GO:0034416 ! bisphosphoglycerate phosphatase activity [Term] id: GO:0004084 name: branched-chain-amino-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: a branched-chain amino acid + 2-oxoglutarate = L-glutamate + a 2-oxocarboxylate derived from the branched-chain amino acid. Includes catalysis of the reaction: L-leucine + 2-oxoglutarate = 4-methyl-2-oxopentanoate + L-glutamate and anaologous reactions involving L-isoleucine and L-valine." [EC:2.6.1.42, GOC:mah] subset: gosubset_prok synonym: "branched-chain amino acid aminotransferase activity" EXACT [] synonym: "branched-chain amino acid-glutamate transaminase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "branched-chain-amino-acid:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "glutamate-branched-chain amino acid transaminase activity" EXACT [EC:2.6.1.42] synonym: "L-branched chain amino acid aminotransferase activity" EXACT [EC:2.6.1.42] synonym: "transaminase B activity" RELATED [EC:2.6.1.42] xref: EC:2.6.1.42 xref: MetaCyc:BRANCHED-CHAINAMINOTRANSFERLEU-RXN xref: Reactome:70697 "branched-chain-amino-acid transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004085 name: butyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: butanoyl-CoA + ETF = 2-butenoyl-CoA + reduced ETF." [EC:1.3.99.2] subset: gosubset_prok synonym: "3-hydroxyacyl CoA reductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butanoyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.2] synonym: "butyryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "butyryl dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "enoyl-coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "ethylene reductase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl CoA dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.2] synonym: "short-chain-acyl-CoA dehydrogenase activity" RELATED [EC:1.3.99.2] synonym: "unsaturated acyl coenzyme A reductase activity" EXACT [EC:1.3.99.2] synonym: "unsaturated acyl-CoA reductase activity" RELATED [EC:1.3.99.2] xref: EC:1.3.99.2 xref: MetaCyc:BUTYRYL-COA-DEHYDROGENASE-RXN xref: UM-BBD_enzymeID:e0034 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004086 name: carbamoyl-phosphate synthase activity namespace: molecular_function def: "Catalysis of a reaction that results in the formation of carbamoyl phosphate." [EC:6.3.4.16, EC:6.3.5.5, GOC:mah] subset: gosubset_prok synonym: "carbamoyl phosphate synthase activity" EXACT [] xref: EC:6.3.-.- is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004087 name: carbamoyl-phosphate synthase (ammonia) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + NH3 + CO2 + H2O = 2 ADP + phosphate + carbamoyl phosphate." [EC:6.3.4.16] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (ammonia) activity" EXACT [] synonym: "carbamoyl-phosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamoyl-phosphate synthetase I activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase (ammonia)" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthase activity" EXACT [EC:6.3.4.16] synonym: "carbamoylphosphate synthetase (ammonia) activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbamylphosphate synthetase I" RELATED [EC:6.3.4.16] synonym: "carbmoylphosphate synthetase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide--ammonia ligase activity" EXACT [EC:6.3.4.16] synonym: "carbon-dioxide:ammonia ligase (ADP-forming, carbamate-phosphorylating)" EXACT [EC:6.3.4.16] synonym: "CPS I activity" NARROW [EC:6.3.4.16] xref: EC:6.3.4.16 xref: MetaCyc:6.3.4.16-RXN xref: Reactome:7296 "carbamoyl-phosphate synthase (ammonia) activity" is_a: GO:0004086 ! carbamoyl-phosphate synthase activity [Term] id: GO:0004088 name: carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity namespace: molecular_function def: "Catalysis of the reaction: 2 ATP + L-glutamine + CO2 + H2O = 2 ADP + phosphate + glutamate + carbamoyl phosphate." [EC:6.3.5.5] subset: gosubset_prok synonym: "carbamoyl phosphate synthase (glutamine-hydrolyzing) activity" EXACT [] synonym: "carbamoyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolysing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoyl-phosphate synthetase (glutamine-hydrolyzing) activity" EXACT [EC:6.3.5.5] synonym: "carbamoylphosphate synthetase II activity" EXACT [EC:6.3.5.5] synonym: "carbamyl phosphate synthetase (glutamine) activity" EXACT [EC:6.3.5.5] synonym: "carbon-dioxide::L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] synonym: "CPS activity" EXACT [EC:6.3.5.5] synonym: "GD-CPSase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamoyl-phosphate synthase activity" EXACT [EC:6.3.5.5] synonym: "glutamine-dependent carbamyl phosphate synthetase activity" EXACT [EC:6.3.5.5] synonym: "hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating) activity" EXACT [EC:6.3.5.5] xref: EC:6.3.5.5 xref: MetaCyc:CARBPSYN-RXN xref: Reactome:7299 "carbamoyl-phosphate synthase (glutamine-hydrolyzing) activity" is_a: GO:0004086 ! carbamoyl-phosphate synthase activity is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004089 name: carbonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: H2CO3 = CO2 + H2O." [EC:4.2.1.1] subset: gosubset_prok synonym: "anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase (carbon-dioxide-forming)" EXACT [EC:4.2.1.1] synonym: "carbonate hydro-lyase activity" EXACT [EC:4.2.1.1] synonym: "carbonic acid anhydrase activity" EXACT [EC:4.2.1.1] synonym: "carbonic anhydrase A" RELATED [EC:4.2.1.1] synonym: "carbonic anhydrase activity" EXACT [] synonym: "carbonic dehydratase activity" EXACT [EC:4.2.1.1] synonym: "carboxyanhydrase activity" EXACT [EC:4.2.1.1] xref: EC:4.2.1.1 xref: MetaCyc:CARBODEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004090 name: carbonyl reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: R-CHOH-R' + NADP+ = R-CO-R' + NADPH + H+." [EC:1.1.1.184] subset: gosubset_prok synonym: "aldehyde reductase 1" RELATED [EC:1.1.1.184] synonym: "aldehyde reductase I activity" RELATED [EC:1.1.1.184] synonym: "ALR3" RELATED [EC:1.1.1.184] synonym: "carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "NADPH2-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "nonspecific NADPH-dependent carbonyl reductase activity" EXACT [EC:1.1.1.184] synonym: "prostaglandin 9-ketoreductase activity" NARROW [EC:1.1.1.184] synonym: "secondary-alcohol:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.184] synonym: "xenobiotic ketone reductase activity" NARROW [EC:1.1.1.184] xref: EC:1.1.1.184 xref: MetaCyc:CARBONYL-REDUCTASE-NADPH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004091 name: carboxylesterase activity namespace: molecular_function alt_id: GO:0004302 alt_id: GO:0004759 alt_id: GO:0016789 def: "Catalysis of the reaction: a carboxylic ester + H2O = an alcohol + a carboxylic anion." [EC:3.1.1.1] subset: gosubset_prok synonym: "Ali-esterase activity" RELATED [EC:3.1.1] synonym: "ali-esterase activity" EXACT [EC:3.1.1] synonym: "alpha-carboxylesterase activity" EXACT [EC:3.1.1] synonym: "B-esterase activity" RELATED [EC:3.1.1] synonym: "carboxyesterase activity" EXACT [EC:3.1.1] synonym: "carboxyl ester hydrolase activity" EXACT [EC:3.1.1] synonym: "carboxylate esterase activity" EXACT [EC:3.1.1] synonym: "carboxylic acid esterase activity" EXACT [] synonym: "carboxylic ester hydrolase activity" EXACT [] synonym: "carboxylic esterase activity" EXACT [EC:3.1.1] synonym: "carboxylic-ester hydrolase activity" EXACT [EC:3.1.1] synonym: "cocaine esterase activity" NARROW [EC:3.1.1] synonym: "esterase A" RELATED [EC:3.1.1] synonym: "esterase B" RELATED [EC:3.1.1] synonym: "nonspecific carboxylesterase activity" EXACT [EC:3.1.1] synonym: "procaine esterase activity" NARROW [EC:3.1.1] synonym: "serine esterase activity" EXACT [] synonym: "triacetin esterase" NARROW [EC:3.1.1] synonym: "vitamin A esterase" NARROW [EC:3.1.1] xref: EC:3.1.1 xref: EC:3.1.1.1 xref: MetaCyc:CARBOXYLESTERASE-RXN xref: UM-BBD_enzymeID:e0631 is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004092 name: carnitine O-acetyltransferase activity namespace: molecular_function alt_id: GO:0004093 alt_id: GO:0004094 def: "Catalysis of the reaction: acetyl-CoA + carnitine = CoA + O-acetylcarnitine." [EC:2.3.1.7] subset: gosubset_prok synonym: "acetyl-CoA-carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetyl-CoA:carnitine O-acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "acetylcarnitine transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyl coenzyme A transferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetylase activity" EXACT [EC:2.3.1.7] synonym: "carnitine acetyltransferase activity" EXACT [EC:2.3.1.7] synonym: "carnitine O-acetyltransferase I activity" NARROW [] synonym: "carnitine O-acetyltransferase II activity" NARROW [] synonym: "carnitine-acetyl-CoA transferase activity" EXACT [EC:2.3.1.7] synonym: "CATC" RELATED [EC:2.3.1.7] xref: EC:2.3.1.7 xref: MetaCyc:CARNITINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:7311 "carnitine O-acetyltransferase activity" is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004095 name: carnitine O-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-carnitine = CoA + L-palmitoylcarnitine." [EC:2.3.1.21] synonym: "acylcarnitine transferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase I" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase II" RELATED [EC:2.3.1.21] synonym: "carnitine palmitoyltransferase-A" RELATED [EC:2.3.1.21] synonym: "CPT" RELATED [EC:2.3.1.21] synonym: "CPT I (outer membrane carnitine palmitoyl transferase)" RELATED [EC:2.3.1.21] synonym: "CPT-A" RELATED [EC:2.3.1.21] synonym: "CPT-B" RELATED [EC:2.3.1.21] synonym: "CPTi" RELATED [EC:2.3.1.21] synonym: "CPTo" RELATED [EC:2.3.1.21] synonym: "L-carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "outer malonyl-CoA inhibitable carnitine palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoyl-CoA:L-carnitine O-palmitoyltransferase activity" EXACT [EC:2.3.1.21] synonym: "palmitoylcarnitine transferase activity" EXACT [EC:2.3.1.21] xref: EC:2.3.1.21 xref: MetaCyc:CARNITINE-O-PALMITOYLTRANSFERASE-RXN xref: Reactome:7324 "carnitine O-palmitoyltransferase activity" is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016416 ! O-palmitoyltransferase activity [Term] id: GO:0004096 name: catalase activity namespace: molecular_function alt_id: GO:0016952 alt_id: GO:0016953 def: "Catalysis of the reaction: 2 H2O2 = O2 + 2 H2O." [EC:1.11.1.6] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "caperase activity" EXACT [EC:1.11.1.6] synonym: "CAT" RELATED [EC:1.11.1.6] synonym: "catalase reaction" EXACT [] synonym: "catalase-peroxidase activity" EXACT [EC:1.11.1.6] synonym: "equilase activity" EXACT [EC:1.11.1.6] synonym: "haem catalase activity" NARROW [] synonym: "heme catalase activity" NARROW [] synonym: "hydrogen-peroxide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.6] synonym: "manganese catalase activity" NARROW [] synonym: "optidase activity" EXACT [EC:1.11.1.6] xref: EC:1.11.1.6 xref: MetaCyc:CATAL-RXN xref: Reactome:76029 "catalase activity" xref: UM-BBD_enzymeID:e0834 is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004097 name: catechol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 catechol + O2 = 2 1,2-benzoquinone + 2 H2O." [EC:1.10.3.1] subset: gosubset_prok synonym: "1,2-benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.1] synonym: "catecholase" BROAD [EC:1.10.3.1] synonym: "diphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "dopa oxidase" BROAD [EC:1.10.3.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.10.3.1] synonym: "o-diphenolase activity" EXACT [EC:1.10.3.1] synonym: "phenolase activity" BROAD [EC:1.10.3.1] synonym: "polyphenol oxidase activity" EXACT [EC:1.10.3.1] synonym: "pyrocatechol oxidase" BROAD [EC:1.10.3.1] synonym: "tyrosinase activity" BROAD [EC:1.10.3.1] xref: EC:1.10.3.1 xref: MetaCyc:CATECHOL-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0004098 name: cerebroside-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: a cerebroside 3-sulfate + H2O = a cerebroside + SO4(2-) (sulfate)." [EC:3.1.6.8] subset: gosubset_prok synonym: "arylsulfatase A activity" EXACT [EC:3.1.6.8] synonym: "cerebroside sulfate sulfatase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-3-sulfate 3-sulfohydrolase activity" EXACT [EC:3.1.6.8] synonym: "cerebroside-sulphatase activity" EXACT [] xref: EC:3.1.6.8 xref: MetaCyc:CEREBROSIDE-SULFATASE-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004099 name: chitin deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: chitin + H2O = chitosan + acetate." [EC:3.5.1.41] subset: gosubset_prok synonym: "chitin amidohydrolase activity" EXACT [EC:3.5.1.41] xref: EC:3.5.1.41 xref: MetaCyc:CHITIN-DEACETYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0004100 name: chitin synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n) = UDP + ((1,4)-(N-acetyl-beta-D-glucosaminyl))(n+1)." [EC:2.4.1.16] subset: gosubset_prok synonym: "chitin synthetase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP acetyl-glucosaminyl transferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-UDP N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "chitin-uridine diphosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.16] synonym: "trans-N-acetylglucosaminosylase activity" EXACT [EC:2.4.1.16] synonym: "UDP-N-acetyl-D-glucosamine:chitin 4-beta-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.16] xref: EC:2.4.1.16 xref: MetaCyc:CHITIN-SYNTHASE-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004102 name: choline O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + choline = CoA + O-acetylcholine." [EC:2.3.1.6] subset: gosubset_prok synonym: "acetyl-CoA:choline O-acetyltransferase activity" EXACT [EC:2.3.1.6] synonym: "CHOACTase activity" EXACT [EC:2.3.1.6] synonym: "choline acetylase activity" EXACT [EC:2.3.1.6] synonym: "choline acetyltransferase activity" EXACT [EC:2.3.1.6] xref: EC:2.3.1.6 xref: MetaCyc:CHOLINE-O-ACETYLTRANSFERASE-RXN xref: Reactome:264627 "choline O-acetyltransferase activity" is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004103 name: choline kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + choline = ADP + O-phosphocholine." [EC:2.7.1.32] subset: gosubset_prok synonym: "ATP:choline phosphotransferase activity" EXACT [EC:2.7.1.32] synonym: "choline kinase (phosphorylating)" EXACT [EC:2.7.1.32] synonym: "choline phosphokinase activity" EXACT [EC:2.7.1.32] synonym: "choline-ethanolamine kinase activity" EXACT [EC:2.7.1.32] xref: EC:2.7.1.32 xref: MetaCyc:CHOLINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004104 name: cholinesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acylcholine + H2O = choline + a carboxylic acid anion." [EC:3.1.1.8] subset: gosubset_prok synonym: "acylcholine acylhydrolase activity" EXACT [EC:3.1.1.8] synonym: "anticholineesterase activity" EXACT [EC:3.1.1.8] synonym: "benzoylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "BtChoEase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholine esterase activity" EXACT [EC:3.1.1.8] synonym: "butyrylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase activity" EXACT [EC:3.1.1.8] synonym: "choline esterase II (unspecific) activity" EXACT [EC:3.1.1.8] synonym: "non-specific cholinesterase activity" EXACT [EC:3.1.1.8] synonym: "propionylcholinesterase activity" EXACT [EC:3.1.1.8] synonym: "pseudocholinesterase activity" EXACT [EC:3.1.1.8] xref: EC:3.1.1.8 xref: MetaCyc:CHOLINESTERASE-RXN xref: Reactome:8144 "cholinesterase activity" is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004105 name: choline-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + choline phosphate = diphosphate + CDP-choline." [EC:2.7.7.15] subset: gosubset_prok synonym: "CDP-choline pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "CDP-choline synthetase activity" EXACT [EC:2.7.7.15] synonym: "choline phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP-phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:choline-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "CTP:phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "cytidine diphosphocholine pyrophosphorylase activity" EXACT [EC:2.7.7.15] synonym: "phosphocholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine cytidylyltransferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine transferase activity" EXACT [EC:2.7.7.15] synonym: "phosphorylcholine:CTP cytidylyltransferase activity" EXACT [EC:2.7.7.15] xref: EC:2.7.7.15 xref: MetaCyc:2.7.7.15-RXN is_a: GO:0070567 ! cytidylyltransferase activity relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004106 name: chorismate mutase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = prephenate." [EC:5.4.99.5] subset: gosubset_prok synonym: "chorismate pyruvatemutase activity" EXACT [EC:5.4.99.5] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:5.4.99.5] xref: EC:5.4.99.5 xref: MetaCyc:CHORISMATEMUT-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004107 name: chorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-O-(1-carboxyvinyl)-3-phosphoshikimate = chorismate + phosphate." [EC:4.2.3.5] subset: gosubset_prok synonym: "5-enolpyruvylshikimate-3-phosphate phospholyase activity" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase (chorismate-forming)" EXACT [EC:4.2.3.5] synonym: "5-O-(1-carboxyvinyl)-3-phosphoshikimate phosphate-lyase activity" EXACT [EC:4.2.3.5] xref: EC:4.2.3.5 xref: MetaCyc:CHORISMATE-SYNTHASE-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004108 name: citrate (Si)-synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + oxaloacetate = citrate + CoA, where the acetyl group is added to the si-face of oxaloacetate; acetyl-CoA thus provides the two carbon atoms of the pro-S carboxymethyl group." [EC:2.3.3.1, ISBN:0121227073] comment: Note that this function was formerly EC:4.1.3.7. subset: gosubset_prok synonym: "(R)-citric synthase activity" EXACT [EC:2.3.3.1] synonym: "acetyl-CoA:oxaloacetate C-acetyltransferase [thioester-hydrolysing, (pro-S)-carboxymethyl forming]" RELATED [EC:2.3.3.1] synonym: "citrate condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH(2)COO(-)->acetyl-CoA) activity" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase ((pro-3S)-CH2COO-rightacetyl-CoA)" EXACT [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COOrightacetyl-CoA]" RELATED [EC:2.3.3.1] synonym: "citrate oxaloacetate-lyase, CoA-acetylating activity" EXACT [EC:2.3.3.1] synonym: "citrate synthase activity" BROAD [EC:2.3.3.1] synonym: "citrate synthetase activity" EXACT [EC:2.3.3.1] synonym: "citric synthase activity" EXACT [EC:2.3.3.1] synonym: "citric-condensing enzyme activity" EXACT [EC:2.3.3.1] synonym: "citrogenase activity" EXACT [EC:2.3.3.1] synonym: "condensing enzyme activity" BROAD [EC:2.3.3.1] synonym: "oxalacetic transacetase activity" EXACT [EC:2.3.3.1] synonym: "oxaloacetate transacetase activity" EXACT [EC:2.3.3.1] xref: EC:2.3.3.1 xref: MetaCyc:CITSYN-RXN xref: Reactome:8157 "citrate (Si)-synthase activity" is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004109 name: coproporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: coproporphyrinogen-III + O2 + 2 H+ = protoporphyrinogen-IX + 2 CO2 + 2 H2O." [EC:1.3.3.3] subset: gosubset_prok synonym: "coprogen oxidase activity" EXACT [] synonym: "coproporphyrinogen-III oxidase activity" EXACT [] synonym: "coproporphyrinogen:oxygen oxidoreductase (decarboxylating)" EXACT [EC:1.3.3.3] synonym: "coproporphyrinogenase activity" EXACT [] xref: EC:1.3.3.3 xref: MetaCyc:RXN0-1461 xref: Reactome:8160 "coproporphyrinogen oxidase activity" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004110 name: corticosteroid side-chain-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 11-deoxycorticosterone = 20-hydroxy-3-oxopregn-4-en-21-al." [EC:5.3.1.21] synonym: "11-deoxycorticosterone aldose-ketose-isomerase activity" EXACT [EC:5.3.1.21] synonym: "11-deoxycorticosterone ketol-isomerase activity" EXACT [EC:5.3.1.21] xref: EC:5.3.1.21 xref: MetaCyc:CORTICOSTEROID-SIDE-CHAIN-ISOMERASE-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004111 name: creatine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + creatine = ADP + phosphocreatine." [EC:2.7.3.2] synonym: "adenosine triphosphate-creatine transphosphorylase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine N-phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "ATP:creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "BB-CK" RELATED [EC:2.7.3.2] synonym: "CK" RELATED [EC:2.7.3.2] synonym: "CK-BB" RELATED [EC:2.7.3.2] synonym: "CK-MB" RELATED [EC:2.7.3.2] synonym: "CK-MM" RELATED [EC:2.7.3.2] synonym: "CKMiMi" RELATED [EC:2.7.3.2] synonym: "creatine phosphokinase activity" EXACT [EC:2.7.3.2] synonym: "creatine phosphotransferase activity" EXACT [EC:2.7.3.2] synonym: "MB-CK" RELATED [EC:2.7.3.2] synonym: "Mi-CK" RELATED [EC:2.7.3.2] synonym: "MiMi-CK" RELATED [EC:2.7.3.2] synonym: "MM-CK" RELATED [EC:2.7.3.2] synonym: "phosphocreatine kinase activity" EXACT [EC:2.7.3.2] xref: EC:2.7.3.2 xref: MetaCyc:CREATINE-KINASE-RXN xref: Reactome:8202 "creatine kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004112 name: cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleoside cyclic phosphate + H2O = a nucleoside phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.4.- is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004113 name: 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate." [EC:3.1.4.37] subset: gosubset_prok synonym: "2',3'-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [] synonym: "2',3'-cyclic nucleotide 3'-phosphohydrolase activity" EXACT [EC:3.1.4.37] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.37] synonym: "2':3'-CNMP-3'-ase activity" EXACT [EC:3.1.4.37] synonym: "2':3'-cyclic nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "CNPase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide 3'-phosphodiesterase activity" EXACT [EC:3.1.4.37] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.37] synonym: "cyclic-CMP phosphodiesterase activity" NARROW [EC:3.1.4.37] synonym: "nucleoside-2',3'-cyclic-phosphate 2'-nucleotidohydrolase activity" EXACT [EC:3.1.4.37] xref: EC:3.1.4.37 xref: MetaCyc:3.1.4.37-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004114 name: 3',5'-cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate." [EC:3.1.4.17] subset: gosubset_prok synonym: "3', 5'-cyclic nucleoside monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5' cyclic-nucleotide phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-cyclonucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "3': 5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "3':5'-cyclic nucleotide 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-mononucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5'-phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic 3',5-nucleotide monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cyclic AMP phosphodiesterase activity" NARROW [EC:3.1.4.17] synonym: "cyclic nucleotide phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "cytidine 3':5'-monophosphate phosphodiesterase (cyclic CMP) activity" EXACT [EC:3.1.4.17] synonym: "nucleoside 3',5'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.17] synonym: "nucleoside-3',5-monophosphate phosphodiesterase activity" EXACT [EC:3.1.4.17] synonym: "PDE" RELATED [EC:3.1.4.17] xref: EC:3.1.4.17 xref: MetaCyc:3.1.4.17-RXN xref: Reactome:8210 "3',5'-cyclic-nucleotide phosphodiesterase activity" is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004115 name: 3',5'-cyclic-AMP phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-cyclic phosphate + H2O = adenosine 5'-phosphate." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cAMP-specific phosphodiesterase activity" EXACT [] synonym: "3',5'-cyclic-AMP-specific phosphodiesterase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-specific phosphodiesterase activity" EXACT [] synonym: "cAMP-specific phosphodiesterase activity" EXACT [] synonym: "cyclic AMP-specific phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- xref: MetaCyc:RXN0-5038 xref: Reactome:8212 "3',5'-cyclic-AMP phosphodiesterase activity" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004117 name: calmodulin-dependent cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is regulated by calmodulin." [GOC:mah] xref: EC:3.1.4.- xref: Reactome:8219 "calmodulin-dependent cyclic-nucleotide phosphodiesterase activity" is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004118 name: cGMP-stimulated cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is increased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004119 name: cGMP-inhibited cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP." [GOC:mah] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004120 name: photoreceptor cyclic-nucleotide phosphodiesterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of bonds in a cyclic nucleotide (nucleoside cyclic phosphate + H2O = nucleoside phosphate)." [EC:3.1.4.-] xref: EC:3.1.4.- is_a: GO:0004114 ! 3',5'-cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0004121 name: cystathionine beta-lyase activity namespace: molecular_function alt_id: GO:0008799 def: "Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate." [EC:4.4.1.8] subset: gosubset_prok synonym: "beta C-S lyase activity" EXACT [EC:4.4.1.8] synonym: "beta-cystathionase activity" EXACT [EC:4.4.1.8] synonym: "cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "cystine lyase activity" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating)" EXACT [EC:4.4.1.8] synonym: "L-cystathionine L-homocysteine-lyase (deaminating; pyruvate-forming)" EXACT [EC:4.4.1.8] xref: EC:4.4.1.8 xref: MetaCyc:CYSTATHIONINE-BETA-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004122 name: cystathionine beta-synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + L-homocysteine = cystathionine + H2O." [EC:4.2.1.22] subset: gosubset_prok synonym: "beta-thionase activity" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine)" EXACT [EC:4.2.1.22] synonym: "L-serine hydro-lyase (adding homocysteine; L-cystathionine-forming)" EXACT [EC:4.2.1.22] synonym: "methylcysteine synthase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrase activity" EXACT [EC:4.2.1.22] synonym: "serine sulfhydrylase activity" EXACT [EC:4.2.1.22] xref: EC:4.2.1.22 xref: MetaCyc:CYSTATHIONINE-BETA-SYNTHASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004123 name: cystathionine gamma-lyase activity namespace: molecular_function alt_id: GO:0016225 def: "Catalysis of the reaction: L-cystathionine + H2O = L-cysteine + NH3 + 2-oxobutanoate." [EC:4.4.1.1] subset: gosubset_prok synonym: "cystalysin" RELATED [EC:4.4.1.1] synonym: "cystathionase activity" EXACT [EC:4.4.1.1] synonym: "cystathioninase activity" EXACT [EC:4.4.1.1] synonym: "cysteine desulfhydrase activity" EXACT [] synonym: "cystine desulfhydrase activity" EXACT [EC:4.4.1.1] synonym: "gamma-CTL" RELATED [EC:4.4.1.1] synonym: "gamma-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase activity" EXACT [EC:4.4.1.1] synonym: "homoserine deaminase-cystathionase activity" EXACT [EC:4.4.1.1] synonym: "homoserine dehydratase activity" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating)" EXACT [EC:4.4.1.1] synonym: "L-cystathionine cysteine-lyase (deaminating; 2-oxobutanoate-forming)" EXACT [EC:4.4.1.1] xref: EC:4.4.1.1 xref: MetaCyc:CYSTAGLY-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004124 name: cysteine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O3-acetyl-L-serine + H2S = L-cysteine + acetate." [EC:4.2.99.8] comment: Note that this function was formerly 4.2.99.8. subset: gosubset_prok synonym: "3-O-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "cysteine synthetase activity" EXACT [EC:2.5.1.47] synonym: "O(3)-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide) activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O-acetyl-L-serine sulfohydrolase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase A activity" NARROW [EC:2.5.1.47] synonym: "O-acetylserine (thiol)-lyase activity" EXACT [EC:2.5.1.47] synonym: "O-acetylserine sulfhydrylase activity" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine acetate-lyase (adding hydrogen-sulfide)" EXACT [EC:2.5.1.47] synonym: "O3-acetyl-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase activity" EXACT [EC:2.5.1.47] synonym: "OAS sulfhydrylase activity" EXACT [EC:2.5.1.47] xref: EC:2.5.1.47 xref: MetaCyc:ACSERLY-RXN is_a: GO:0016835 ! carbon-oxygen lyase activity relationship: part_of GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0004125 name: L-seryl-tRNASec selenium transferase activity namespace: molecular_function def: "Catalysis of the reaction: L-seryl-tRNA(Sec) + selenophosphate = L-selenocysteinyl-tRNA(Sec) + H2O + phosphate." [EC:2.9.1.1] subset: gosubset_prok synonym: "cysteinyl-tRNA(Sec)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Sel)-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "cysteinyl-tRNASec-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "cysteinyl-tRNASel-selenium transferase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sec) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNA(Sel) synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASec synthase activity" EXACT [EC:2.9.1.1] synonym: "L-selenocysteinyl-tRNASel synthase activity" EXACT [EC:2.9.1.1] synonym: "L-seryl-tRNA(Ser) selenium transferase activity" EXACT [] synonym: "selenocysteine synthase activity" EXACT [] synonym: "selenocysteinyl-tRNA(Ser) synthase activity" EXACT [] synonym: "selenophosphate:L-seryl-tRNASec selenium transferase activity" EXACT [EC:2.9.1.1] xref: EC:2.9.1.1 xref: MetaCyc:2.9.1.1-RXN is_a: GO:0016786 ! selenotransferase activity [Term] id: GO:0004126 name: cytidine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytidine + H2O = uridine + NH3." [EC:3.5.4.5] subset: gosubset_prok synonym: "cytidine aminohydrolase activity" EXACT [EC:3.5.4.5] synonym: "cytosine nucleoside deaminase activity" EXACT [EC:3.5.4.5] xref: EC:3.5.4.5 xref: MetaCyc:CYTIDEAM2-RXN xref: Reactome:8270 "cytidine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity relationship: part_of GO:0009972 ! cytidine deamination [Term] id: GO:0004127 name: cytidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)CMP = ADP + (d)CDP." [EC:2.7.4.14] subset: gosubset_prok synonym: "ATP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "ATP:UMP-CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "CMP kinase activity" NARROW [EC:2.7.4.14] synonym: "CTP:CMP phosphotransferase activity" EXACT [EC:2.7.4.14] synonym: "cytidine monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "dCMP kinase activity" NARROW [EC:2.7.4.14] synonym: "deoxycytidine monophosphokinase activity" EXACT [EC:2.7.4.14] synonym: "deoxycytidylate kinase activity" BROAD [EC:2.7.4.14] synonym: "pyrimidine nucleoside monophosphate kinase activity" EXACT [EC:2.7.4.14] synonym: "UMP-CMP kinase activity" EXACT [EC:2.7.4.14] xref: EC:2.7.4.14 xref: MetaCyc:CMPKI-RXN is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004128 name: cytochrome-b5 reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + 2 ferricytochrome b(5) = NAD+ + 2 ferrocytochrome b(5)." [EC:1.6.2.2, ISBN:0198547684] synonym: "cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "dihydronicotinamide adenine dinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH 5alpha-reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-cytochrome-b5 reductase activity" EXACT [EC:1.6.2.2] synonym: "NADH-ferricytochrome b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "NADH:ferricytochrome-b5 oxidoreductase activity" EXACT [EC:1.6.2.2] synonym: "reduced nicotinamide adeninedinucleotide-cytochrome b5 reductase activity" EXACT [EC:1.6.2.2] xref: EC:1.6.2.2 xref: MetaCyc:CYTOCHROME-B5-REDUCTASE-RXN xref: Reactome:8276 "cytochrome-b5 reductase activity" is_a: GO:0016653 ! oxidoreductase activity, acting on NADH or NADPH, heme protein as acceptor [Term] id: GO:0004129 name: cytochrome-c oxidase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] subset: gosubset_prok synonym: "aa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ba3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "caa3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "cbb3-type cytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "complex IV (mitochondrial electron transport) activity" RELATED [EC:1.9.3.1] synonym: "cytochrome a3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome aa3 activity" NARROW [EC:1.9.3.1] synonym: "cytochrome oxidase activity" RELATED [EC:1.9.3.1] synonym: "ferrocytochrome c oxidase" NARROW [EC:1.9.3.1] synonym: "ferrocytochrome-c:oxygen oxidoreductase" NARROW [EC:1.9.3.1] synonym: "indophenol oxidase" NARROW [EC:1.9.3.1] synonym: "indophenolase" NARROW [EC:1.9.3.1] synonym: "NADH cytochrome c oxidase" EXACT [EC:1.9.3.1] synonym: "warburg's respiratory enzyme activity" RELATED [EC:1.9.3.1] xref: EC:1.9.3.1 xref: MetaCyc:CYTOCHROME-C-OXIDASE-RXN xref: Reactome:8283 "cytochrome-c oxidase activity" is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016676 ! oxidoreductase activity, acting on heme group of donors, oxygen as acceptor [Term] id: GO:0004130 name: cytochrome-c peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 ferrocytochrome c + H2O2 = 2 ferricytochrome c + 2 H2O." [EC:1.11.1.5] subset: gosubset_prok synonym: "apocytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-551 peroxidase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome c-H2O oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "cytochrome peroxidase activity" EXACT [EC:1.11.1.5] synonym: "ferrocytochrome-c:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase azide" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanate" RELATED [EC:1.11.1.5] synonym: "mesocytochrome c peroxidase cyanide" RELATED [EC:1.11.1.5] xref: EC:1.11.1.5 xref: MetaCyc:CYTOCHROME-C-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004131 name: cytosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: cytosine + H2O = uracil + NH3." [EC:3.5.4.1] subset: gosubset_prok synonym: "cytosine aminohydrolase activity" EXACT [EC:3.5.4.1] synonym: "isocytosine deaminase activity" EXACT [EC:3.5.4.1] xref: EC:3.5.4.1 xref: MetaCyc:CYTDEAM-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004132 name: dCMP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCMP + H2O = dUMP + NH3." [EC:3.5.4.12] subset: gosubset_prok synonym: "dCMP aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxy-CMP-deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine monophosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-monophosphate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidine-5'-phosphate deaminase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate aminohydrolase activity" EXACT [EC:3.5.4.12] synonym: "deoxycytidylate deaminase activity" EXACT [EC:3.5.4.12] xref: EC:3.5.4.12 xref: MetaCyc:DCMP-DEAMINASE-RXN xref: Reactome:8340 "dCMP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004133 name: glycogen debranching enzyme activity namespace: molecular_function def: "Catalysis of the cleavage of branch points in branched glycogen polymers." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004134 name: 4-alpha-glucanotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a segment of a (1,4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1,4)-alpha-D-glucan." [EC:2.4.1.25] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "amylomaltase activity" EXACT [EC:2.4.1.25] synonym: "D-enzyme activity" RELATED [EC:2.4.1.25] synonym: "debranching enzyme maltodextrin glycosyltransferase activity" EXACT [EC:2.4.1.25] synonym: "dextrin glycosyltransferase activity" RELATED [EC:2.4.1.25] synonym: "dextrin transglycosylase activity" EXACT [EC:2.4.1.25] synonym: "disproportionating enzyme activity" RELATED [EC:2.4.1.25] synonym: "oligo-1,4-1,4-glucantransferase activity" EXACT [EC:2.4.1.25] xref: EC:2.4.1.25 xref: MetaCyc:AMYLOMALT-RXN xref: MetaCyc:RXN-1828 xref: MetaCyc:RXN-9023 xref: Reactome:8344 "4-alpha-glucanotransferase activity" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004135 name: amylo-alpha-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (1,6)-alpha-D-glucosidic branch linkages in glycogen phosphorylase limit dextrin. Limit dextrin is the highly branched core that remains after exhaustive treatment of glycogen with glycogen phosphorylase. It is formed because these enzymes cannot hydrolyze the 1,6 glycosidic linkages present." [EC:3.2.1.33, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amylo-1,6-glucosidase activity" EXACT [] synonym: "amylopectin 1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "dextrin 6-alpha-D-glucosidase activity" RELATED [EC:3.2.1.33] synonym: "dextrin-1,6-glucosidase activity" EXACT [EC:3.2.1.33] synonym: "glycogen phosphorylase-limit dextrin alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.33] xref: EC:3.2.1.33 xref: MetaCyc:3.2.1.33-RXN xref: Reactome:8347 "amylo-alpha-1,6-glucosidase activity" is_a: GO:0004133 ! glycogen debranching enzyme activity is_a: GO:0004558 ! alpha-glucosidase activity [Term] id: GO:0004136 name: deoxyadenosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyadenosine = ADP + dAMP." [EC:2.7.1.76] subset: gosubset_prok synonym: "ATP:deoxyadenosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.76] synonym: "deoxyadenosine kinase (phosphorylating)" EXACT [EC:2.7.1.76] synonym: "purine-deoxyribonucleoside kinase activity" EXACT [EC:2.7.1.76] xref: EC:2.7.1.76 xref: MetaCyc:DEOXYADENOSINE-KINASE-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004137 name: deoxycytidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + deoxycytidine = NDP + CMP." [EC:2.7.1.74] subset: gosubset_prok synonym: "2'-deoxycytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "Ara-C kinase activity" EXACT [EC:2.7.1.74] synonym: "arabinofuranosylcytosine kinase activity" EXACT [EC:2.7.1.74] synonym: "deoxycytidine kinase (phosphorylating)" EXACT [EC:2.7.1.74] synonym: "deoxycytidine-cytidine kinase activity" EXACT [EC:2.7.1.74] synonym: "NTP:deoxycytidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.74] xref: EC:2.7.1.74 xref: MetaCyc:DEOXYCYTIDINE-KINASE-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004138 name: deoxyguanosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + deoxyguanosine = ADP + dGMP." [EC:2.7.1.113] subset: gosubset_prok synonym: "(dihydroxypropoxymethyl)guanine kinase activity" EXACT [EC:2.7.1.113] synonym: "2'-deoxyguanosine kinase activity" EXACT [EC:2.7.1.113] synonym: "ATP:deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] synonym: "deoxyguanosine kinase (phosphorylating)" EXACT [EC:2.7.1.113] synonym: "NTP-deoxyguanosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.113] xref: EC:2.7.1.113 xref: MetaCyc:DEOXYGUANOSINE-KINASE-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004139 name: deoxyribose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-ribose 5-phosphate = D-glyceraldehyde 3-phosphate + acetaldehyde." [EC:4.1.2.4] subset: gosubset_prok synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase (D-glyceraldehyde-3-phosphate-forming)" EXACT [EC:4.1.2.4] synonym: "2-deoxy-D-ribose-5-phosphate acetaldehyde-lyase activity" EXACT [EC:4.1.2.4] synonym: "2-deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "deoxyriboaldolase activity" RELATED [EC:4.1.2.4] synonym: "deoxyribose-5-phosphate aldolase activity" EXACT [EC:4.1.2.4] synonym: "phosphodeoxyriboaldolase activity" EXACT [EC:4.1.2.4] xref: EC:4.1.2.4 xref: MetaCyc:DEOXYRIBOSE-P-ALD-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004140 name: dephospho-CoA kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dephospho-CoA = ADP + CoA." [EC:2.7.1.24] subset: gosubset_prok synonym: "3'-dephospho-CoA kinase activity" EXACT [EC:2.7.1.24] synonym: "ATP:dephospho-CoA 3'-phosphotransferase activity" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase (phosphorylating)" EXACT [EC:2.7.1.24] synonym: "dephosphocoenzyme A kinase activity" RELATED [EC:2.7.1.24] xref: EC:2.7.1.24 xref: MetaCyc:DEPHOSPHOCOAKIN-RXN xref: Reactome:8372 "dephospho-CoA kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004141 name: dethiobiotin synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 7,8-diaminononanoate + CO2 = ADP + phosphate + dethiobiotin." [EC:6.3.3.3] subset: gosubset_prok synonym: "7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.3] synonym: "desthiobiotin synthase activity" EXACT [EC:6.3.3.3] synonym: "DTB synthetase activity" EXACT [EC:6.3.3.3] xref: EC:6.3.3.3 xref: MetaCyc:DETHIOBIOTIN-SYN-RXN is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004142 name: diacylglycerol cholinephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-choline + 1,2-diacylglycerol = CMP + a phosphatidylcholine." [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-m-glycerol:CDPcholine choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "1-alkyl-2-acetylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "alkylacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline diglyceride phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "CDP-choline:1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "cholinephosphotransferase activity" RELATED [EC:2.7.8.2] synonym: "CPT" RELATED [EC:2.7.8.2] synonym: "cytidine diphosphocholine glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "cytidine diphosphorylcholine diglyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "diacylglycerol choline phosphotransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphocholine diacylglyceroltransferase activity" EXACT [EC:2.7.8.2] synonym: "phosphorylcholine--glyceride transferase activity" EXACT [EC:2.7.8.2] synonym: "sn-1,2-diacylglycerol cholinephosphotransferase activity" EXACT [EC:2.7.8.2] xref: EC:2.7.8.2 xref: MetaCyc:RXN-5781 is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity relationship: part_of GO:0006657 ! CDP-choline pathway [Term] id: GO:0004143 name: diacylglycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + 1,2-diacylglycerol = NDP + 1,2-diacylglycerol 3-phosphate." [EC:2.7.1.107, GOC:elh] subset: gosubset_prok synonym: "1,2-diacylglycerol kinase (phosphorylating)" EXACT [EC:2.7.1.107] synonym: "1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "arachidonoyl-specific diacylglycerol kinase activity" EXACT [EC:2.7.1.107] synonym: "ATP:1,2-diacylglycerol 3-phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "ATP:diacylglycerol phosphotransferase activity" NARROW [EC:2.7.1.107] synonym: "CTP:diacylglycerol kinase activity" NARROW [] synonym: "DG kinase activity" EXACT [EC:2.7.1.107] synonym: "DGK activity" EXACT [EC:2.7.1.107] synonym: "diacylglycerol:ATP kinase activity" NARROW [EC:2.7.1.107] synonym: "diglyceride kinase activity" EXACT [EC:2.7.1.107] synonym: "sn-1,2-diacylglycerol kinase activity" EXACT [EC:2.7.1.107] xref: EC:2.7.1.107 xref: MetaCyc:DIACYLGLYKIN-RXN xref: Reactome:8381 "diacylglycerol kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004144 name: diacylglycerol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol." [EC:2.3.1.20] subset: gosubset_prok synonym: "1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "acyl-CoA:1,2-diacylglycerol O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "diglyceride O-acyltransferase activity" EXACT [EC:2.3.1.20] synonym: "palmitoyl-CoA-sn-1,2-diacylglycerol acyltransferase activity" EXACT [EC:2.3.1.20] xref: EC:2.3.1.20 xref: MetaCyc:DIACYLGLYCEROL-O-ACYLTRANSFERASE-RXN xref: Reactome:8383 "diacylglycerol O-acyltransferase activity" is_a: GO:0016411 ! acylglycerol O-acyltransferase activity [Term] id: GO:0004145 name: diamine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + an alkane-alpha,omega-diamine = CoA + an N-acetyldiamine." [EC:2.3.1.57] subset: gosubset_prok synonym: "acetyl-CoA:alkane-alpha,omega-diamine N-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "acetyl-coenzyme A-1,4-diaminobutane N-acetyltransferase activity" NARROW [] synonym: "diamine acetyltransferase activity" EXACT [] synonym: "putrescine (diamine)-acetylating enzyme activity" NARROW [] synonym: "putrescine acetylase activity" NARROW [EC:2.3.1.57] synonym: "putrescine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "putrescine N-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N(1)-acetyltransferase activity" NARROW [EC:2.3.1.57] synonym: "spermidine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermidine/spermine N1-acetyltransferase activity" EXACT [EC:2.3.1.57] synonym: "spermine acetyltransferase" NARROW [] synonym: "spermine N(1)-acetyltransferase" NARROW [] synonym: "spermine N-acetyltransferase" RELATED [] xref: EC:2.3.1.57 xref: MetaCyc:DIAMACTRANS-RXN xref: Reactome:8388 "diamine N-acetyltransferase activity" is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004146 name: dihydrofolate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+." [EC:1.5.1.3] subset: gosubset_prok synonym: "5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.3] synonym: "7,8-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "DHFR" RELATED [EC:1.5.1.3] synonym: "dihydrofolate reductase:thymidylate synthase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolate reduction" EXACT [] synonym: "dihydrofolic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "dihydrofolic reductase activity" EXACT [EC:1.5.1.3] synonym: "folic acid reductase activity" EXACT [EC:1.5.1.3] synonym: "folic reductase activity" EXACT [EC:1.5.1.3] synonym: "NADPH-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "pteridine reductase:dihydrofolate reductase activity" EXACT [EC:1.5.1.3] synonym: "tetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.3] synonym: "thymidylate synthetase-dihydrofolate reductase activity" EXACT [EC:1.5.1.3] xref: EC:1.5.1.3 xref: MetaCyc:DIHYDROFOLATEREDUCT-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004147 name: dihydrolipoamide branched chain acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + dihydrolipoamide = CoA + S-acyldihydrolipoamide, where the acyl group is a branched chain." [GOC:mah] subset: gosubset_prok synonym: "dihydrolipoamide branched chain transacylase activity" EXACT [] xref: EC:2.3.1.- is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004148 name: dihydrolipoyl dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: protein N6-(dihydrolipoyl)lysine + NAD+ = protein N6-(lipoyl)lysine + NADH + H+." [EC:1.8.1.4] subset: gosubset_prok synonym: "dehydrolipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "diaphorase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoamide reduction" RELATED [EC:1.8.1.4] synonym: "dihydrolipoamide:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "dihydrolipoic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "dihydrolipoylprotein reduction" RELATED [EC:1.8.1.4] synonym: "dihydrothioctic dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "E3 component of alpha-ketoacid dehydrogenase complexes activity" RELATED [EC:1.8.1.4] synonym: "glycine-cleavage system L-protein activity" RELATED [EC:1.8.1.4] synonym: "L-protein activity" RELATED [EC:1.8.1.4] synonym: "LDP-Glc activity" NARROW [EC:1.8.1.4] synonym: "LDP-Val activity" NARROW [EC:1.8.1.4] synonym: "lipoamide dehydrogenase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide oxidoreductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase (NADH) activity" EXACT [EC:1.8.1.4] synonym: "lipoamide reductase activity" EXACT [EC:1.8.1.4] synonym: "lipoate dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoic acid dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "lipoyl dehydrogenase activity" EXACT [EC:1.8.1.4] synonym: "protein-6-N-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] synonym: "protein-N6-(dihydrolipoyl)lysine:NAD+ oxidoreductase" EXACT [EC:1.8.1.4] xref: EC:1.8.1.4 xref: MetaCyc:DIHYDLIPOXN-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004149 name: dihydrolipoyllysine-residue succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + dihydrolipoamide = CoA + S-succinyldihydrolipoamide." [EC:2.3.1.61] subset: gosubset_prok synonym: "dihydrolipoamide S-succinyltransferase activity" EXACT [] synonym: "dihydrolipoamide succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipolyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "dihydrolipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "enzyme-dihydrolipoyllysine:succinyl-CoA S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase (Escherichia coli) activity" EXACT [EC:2.3.1.61] synonym: "lipoate succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "lipoic transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "lipoyl transsuccinylase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoamide S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:dihydrolipoate S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-6-N-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] synonym: "succinyl-CoA:enzyme-N6-(dihydrolipoyl)lysine S-succinyltransferase activity" EXACT [EC:2.3.1.61] xref: EC:2.3.1.61 is_a: GO:0016751 ! S-succinyltransferase activity [Term] id: GO:0004150 name: dihydroneopterin aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde." [EC:4.1.2.25] subset: gosubset_prok synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase (2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-forming)" EXACT [EC:4.1.2.25] synonym: "2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine glycolaldehyde-lyase activity" EXACT [EC:4.1.2.25] xref: EC:4.1.2.25 xref: MetaCyc:H2NEOPTERINALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004151 name: dihydroorotase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + H2O = N-carbamoyl-L-aspartate." [EC:3.5.2.3] subset: gosubset_prok synonym: "(S)-dihydroorotate amidohydrolase activity" EXACT [EC:3.5.2.3] synonym: "carbamoylaspartic dehydrase activity" EXACT [EC:3.5.2.3] synonym: "DHOase activity" EXACT [EC:3.5.2.3] synonym: "dihydroorotate hydrolase activity" EXACT [EC:3.5.2.3] xref: EC:3.5.2.3 xref: MetaCyc:DIHYDROOROT-RXN xref: Reactome:8410 "dihydroorotase activity" is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004152 name: dihydroorotate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + acceptor = orotate + reduced acceptor." [EC:1.3.99.11] subset: gosubset_prok synonym: "(DHO) dehydrogenase activity" RELATED [EC:1.3.3.1] synonym: "(S)-dihydroorotate:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.11] synonym: "(S)-dihydroorotate:acceptor oxidoreductase activity" EXACT [EC:1.3.99.11] synonym: "DHOdehase activity" EXACT [EC:1.3.3.1] synonym: "dihydoorotic acid dehydrogenase activity" EXACT [EC:1.3.3.1] synonym: "dihydroorotate:ubiquinone oxidoreductase activity" NARROW [EC:1.3.99.11] xref: EC:1.3.99.11 xref: MetaCyc:DIHYDROOROTATE-DEHYDROGENASE-RXN xref: Reactome:8412 "dihydroorotate dehydrogenase activity" is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0004153 name: dihydropterin deaminase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydropterin + H20 = 7,8-dihydrolumazine + NH3." [FB:FBrf0039640, GOC:jl, http://www.abbs.info/fulltxt/eng/35030306.htm, ISSN:05829879] is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004154 name: dihydropterin oxidase activity namespace: molecular_function def: "Catalysis of the reaction: a 7,8-dihydropteridine + O2 = a pterin + H2O2." [GOC:mah, PMID:1745247, PMID:6815189] xref: EC:1.5.3.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004155 name: 6,7-dihydropteridine reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADP+ + 5,6,7,8-tetrahydropteridine = NADPH + H+ + 6,7-dihydropteridine." [EC:1.5.1.34] comment: Note that this function was formerly EC:1.6.99.7. subset: gosubset_prok synonym: "5,6,7,8-tetrahydropteridine:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "5,6,7,8-tetrahydropteridine:NAD(P)H+ oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "6,7-dihydropteridine:NAD(P)H oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "DHPR activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine (reduced nicotinamide adenine dinucleotide) reductase activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase (NADH) activity" EXACT [EC:1.5.1.34] synonym: "dihydropteridine reductase activity" EXACT [] synonym: "dihydropteridine reduction" RELATED [] synonym: "NAD(P)H(2):6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NAD(P)H2:6,7-dihydropteridine oxidoreductase activity" EXACT [EC:1.5.1.34] synonym: "NADH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-dihydropteridine reductase activity" EXACT [EC:1.5.1.34] synonym: "NADPH-specific dihydropteridine reductase activity" EXACT [EC:1.5.1.34] xref: EC:1.5.1.34 xref: MetaCyc:1.5.1.34-RXN xref: Reactome:8421 "6,7-dihydropteridine reductase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004156 name: dihydropteroate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine diphosphate + 4-aminobenzoate = diphosphate + dihydropteroate." [EC:2.5.1.15] subset: gosubset_prok synonym: "(2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine-diphosphate:4-aminobenzoate 2-amino-4-hydroxydihydropteridine-6-methenyltransferase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "7,8-dihydropteroic acid synthetase activity" EXACT [EC:2.5.1.15] synonym: "DHPS activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate diphosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate pyrophosphorylase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroate synthetase activity" EXACT [EC:2.5.1.15] synonym: "dihydropteroic synthetase activity" EXACT [EC:2.5.1.15] xref: EC:2.5.1.15 xref: MetaCyc:H2PTEROATESYNTH-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004157 name: dihydropyrimidinase activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + H2O = 3-ureidopropionate." [EC:3.5.2.2] subset: gosubset_prok synonym: "5,6-dihydropyrimidine amidohydrolase activity" EXACT [EC:3.5.2.2] synonym: "D-hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydantoin peptidase activity" EXACT [EC:3.5.2.2] synonym: "hydantoinase activity" EXACT [EC:3.5.2.2] synonym: "hydropyrimidine hydrase activity" EXACT [EC:3.5.2.2] synonym: "pyrimidine hydrase activity" EXACT [EC:3.5.2.2] xref: EC:3.5.2.2 xref: MetaCyc:DIHYDROPYRIMIDINASE-RXN xref: Reactome:8430 "dihydropyrimidinase activity" is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0004158 name: dihydroorotate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + O2 = orotate + H2O2." [EC:1.3.3.1] subset: gosubset_prok synonym: "(S)-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] synonym: "4,5-L-dihydroorotate:oxygen oxidoreductase activity" EXACT [EC:1.3.3.1] xref: EC:1.3.3.1 xref: MetaCyc:DIHYDROOROTOX-RXN is_a: GO:0004152 ! dihydroorotate dehydrogenase activity is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor [Term] id: GO:0004159 name: dihydrouracil dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,6-dihydrouracil + NAD+ = uracil + NADH + H+." [EC:1.3.1.1] synonym: "5,6-dihydrouracil:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.1] synonym: "dehydrogenase, dihydrouracil" EXACT [EC:1.3.1.1] synonym: "pyrimidine reductase activity" EXACT [EC:1.3.1.1] synonym: "thymine reductase activity" EXACT [EC:1.3.1.1] synonym: "uracil reductase activity" EXACT [EC:1.3.1.1] xref: EC:1.3.1.1 xref: MetaCyc:DIHYDROURACIL-DEHYDROGENASE-NAD+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004160 name: dihydroxy-acid dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydroxy-3-methylbutanoate = 3-methyl-2-oxobutanoate + H2O." [EC:4.2.1.9] subset: gosubset_prok synonym: "2,3-dihydroxy-acid hydro-lyase (3-methyl-2-oxobutanoate-forming)" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxy-acid hydro-lyase activity" EXACT [EC:4.2.1.9] synonym: "2,3-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "acetohydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyacid dehydratase activity" EXACT [EC:4.2.1.9] synonym: "alpha,beta-dihydroxyisovalerate dehydratase activity" EXACT [EC:4.2.1.9] synonym: "DHAD" RELATED [EC:4.2.1.9] synonym: "dihydroxy acid dehydrase activity" EXACT [EC:4.2.1.9] xref: EC:4.2.1.9 xref: MetaCyc:DIHYDROXYISOVALDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004161 name: dimethylallyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: dimethylallyl diphosphate + isopentenyl diphosphate = diphosphate + geranyl diphosphate." [EC:2.5.1.1] comment: Note that this is the first step in the formation of farnesyl diphosphate. The second step is 'geranyltranstransferase activity ; GO:0004337'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "(2E,6E)-farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyl-diphosphate:isopentenyl-diphosphate dimethylallyltranstransferase activity" EXACT [EC:2.5.1.1] synonym: "dimethylallyltransferase activity" EXACT [] synonym: "diprenyltransferase activity" EXACT [EC:2.5.1.1] synonym: "DMAPP:IPP-dimethylallyltransferase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.1] synonym: "geranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] synonym: "geranyl-diphosphate synthase activity" RELATED [EC:2.5.1.1] synonym: "trans-farnesyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.1] xref: EC:2.5.1.1 xref: MetaCyc:GPPSYN-RXN is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004162 name: dimethylnitrosamine demethylase activity namespace: molecular_function def: "Catalysis of the removal of a methyl group from N-nitrosodimethylamine." [GOC:mah] synonym: "N-nitrosodimethylamine demethylase activity" EXACT [] is_a: GO:0032451 ! demethylase activity [Term] id: GO:0004163 name: diphosphomevalonate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-5-diphosphomevalonate = ADP + phosphate + isopentenyl diphosphate + CO2." [EC:4.1.1.33] subset: gosubset_prok synonym: "5-pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (adding ATP; isopentenyl-diphosphate-forming)" EXACT [EC:4.1.1.33] synonym: "ATP:(R)-5-diphosphomevalonate carboxy-lyase (dehydrating)" EXACT [EC:4.1.1.33] synonym: "mevalonate 5-diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate diphosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "mevalonate-5-pyrophosphate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonate decarboxylase activity" EXACT [EC:4.1.1.33] synonym: "pyrophosphomevalonic acid decarboxylase activity" EXACT [EC:4.1.1.33] xref: EC:4.1.1.33 xref: MetaCyc:DIPHOSPHOMEVALONTE-DECARBOXYLASE-RXN xref: Reactome:8449 "diphosphomevalonate decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004164 name: diphthine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 2-(3-carboxy-3-aminopropyl)-L-histidine = S-adenosyl-L-homocysteine + 2-(3-carboxy-3-(methylammonio)propyl)-L-histidine." [EC:2.1.1.98] subset: gosubset_prok synonym: "diphthine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:2-(3-carboxy-3-aminopropyl)-L-histidine methyltransferase activity" EXACT [EC:2.1.1.98] synonym: "S-adenosyl-L-methionine:elongation factor 2 methyltransferase activity" EXACT [EC:2.1.1.98] xref: EC:2.1.1.98 xref: MetaCyc:RXN-11370 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004165 name: dodecenoyl-CoA delta-isomerase activity namespace: molecular_function alt_id: GO:0008461 def: "Catalysis of the reaction: 3-cis-dodecenoyl-CoA = 2-trans-dodecenoyl-CoA." [EC:5.3.3.8] subset: gosubset_prok synonym: "3,2-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "acetylene-allene isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3),Delta(2)-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta(3)-cis-Delta(2)-trans-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3,Delta2-enoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] synonym: "delta3-cis-delta2-trans-enoyl-CoA isomerase" BROAD [EC:5.3.3.8] synonym: "dodecenoyl-CoA (3Z)-(2E)-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA D-isomerase activity" EXACT [] synonym: "dodecenoyl-CoA Delta-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA delta3-cis-delta2-trans-isomerase activity" EXACT [EC:5.3.3.8] synonym: "dodecenoyl-CoA isomerase activity" EXACT [EC:5.3.3.8] xref: EC:5.3.3.8 xref: MetaCyc:ENOYL-COA-DELTA-ISOM-RXN xref: Reactome:8459 "dodecenoyl-CoA delta-isomerase activity" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004166 name: dolichyl-phosphate alpha-N-acetylglucosaminyltransferase activity namespace: molecular_function alt_id: GO:0004101 def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + dolichyl phosphate = UDP + dolichyl N-acetyl-alpha-D-glucosaminyl phosphate." [EC:2.4.1.153] synonym: "dolichyl phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "dolichyl-phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetyl-D-glucosamine:dolichyl-phosphate alpha-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "UDP-N-acetylglucosamine-dolichol phosphate N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] synonym: "uridine diphosphoacetylglucosamine-dolichol phosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.153] xref: EC:2.4.1.153 xref: MetaCyc:2.4.1.153-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004167 name: dopachrome isomerase activity namespace: molecular_function alt_id: GO:0048059 def: "Catalysis of the reaction: L-dopachrome = 5,6-dihydroxyindole-2-carboxylate." [EC:5.3.3.12] synonym: "DCF activity" EXACT [EC:5.3.3.12] synonym: "DCT activity" EXACT [EC:5.3.3.12] synonym: "dopachrome conversion activity" BROAD [] synonym: "dopachrome conversion factor activity" BROAD [EC:5.3.3.12] synonym: "dopachrome Delta(7),Delta(2)-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome delta-isomerase activity" EXACT [] synonym: "dopachrome delta7,Delta2-isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome oxidoreductase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome rearranging enzyme activity" EXACT [EC:5.3.3.12] synonym: "dopachrome tautomerase activity" EXACT [EC:5.3.3.12] synonym: "dopachrome-rearranging enzyme" RELATED [EC:5.3.3.12] synonym: "L-dopachrome isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome keto-enol isomerase activity" EXACT [EC:5.3.3.12] synonym: "L-dopachrome-methyl ester tautomerase activity" EXACT [EC:5.3.3.12] synonym: "TRP activity" EXACT [EC:5.3.3.12] synonym: "TRP-1" RELATED [EC:5.3.3.12] synonym: "TRP-2" RELATED [EC:5.3.3.12] synonym: "TRP2" RELATED [EC:5.3.3.12] synonym: "tryosinase-related protein-2" RELATED [EC:5.3.3.12] synonym: "tyrosinase-related protein 2 activity" EXACT [EC:5.3.3.12] xref: EC:5.3.3.12 xref: MetaCyc:DOPACHROME-DELTA-ISOMERASE-RXN is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004168 name: dolichol kinase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + dolichol = CDP + dolichyl phosphate." [EC:2.7.1.108] synonym: "CTP:dolichol O-phosphotransferase activity" EXACT [EC:2.7.1.108] synonym: "dolichol phosphokinase activity" EXACT [EC:2.7.1.108] xref: EC:2.7.1.108 xref: MetaCyc:DOLICHOL-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004169 name: dolichyl-phosphate-mannose-protein mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl phosphate D-mannose + protein = dolichyl phosphate + O-D-mannosylprotein." [EC:2.4.1.109] subset: gosubset_prok synonym: "dolichol phosphomannose-protein mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-D-mannose:protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "dolichyl-phosphate-mannose-protein O-mannosyltransferase activity" EXACT [] synonym: "O-glycoside mannosyltransferase" BROAD [] synonym: "protein O-D-mannosyltransferase activity" EXACT [EC:2.4.1.109] synonym: "protein O-mannosyltransferase activity" EXACT [] xref: EC:2.4.1.109 xref: MetaCyc:2.4.1.109-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004170 name: dUTP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: dUTP + H2O = dUMP + diphosphate." [EC:3.6.1.23] subset: gosubset_prok synonym: "deoxyuridine-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphatase activity" EXACT [EC:3.6.1.23] synonym: "desoxyuridine 5'-triphosphate nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP nucleotidohydrolase activity" EXACT [EC:3.6.1.23] synonym: "dUTP pyrophosphatase activity" EXACT [] synonym: "dUTPase activity" EXACT [EC:3.6.1.23] xref: EC:3.6.1.23 xref: MetaCyc:DUTP-PYROP-RXN xref: Reactome:8479 "dUTP diphosphatase activity" is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0004171 name: deoxyhypusine synthase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: [eIF5A-precursor]-lysine + spermidine = [eIF5A-precursor]-deoxyhypusine + propane-1,3-diamine." [EC:2.5.1.46] comment: This term was made obsolete because it represents a multistep reaction. synonym: "[eIF-5A]-deoxyhypusine synthase" RELATED [] is_obsolete: true replaced_by: GO:0008612 replaced_by: GO:0034038 replaced_by: GO:0050983 [Term] id: GO:0004172 name: ecdysteroid UDP-glucosyl/UDP-glucuronosyl transferase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents two molecular functions. is_obsolete: true consider: GO:0050488 [Term] id: GO:0004173 name: ecdysone O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + ecdysone = CoA + ecdysone palmitate." [EC:2.3.1.139] synonym: "acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "fatty acyl-CoA:ecdysone acyltransferase activity" EXACT [EC:2.3.1.139] synonym: "palmitoyl-CoA:ecdysone palmitoyltransferase activity" EXACT [EC:2.3.1.139] xref: EC:2.3.1.139 xref: MetaCyc:ECDYSONE-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004174 name: electron-transferring-flavoprotein dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ETF + ubiquinone = ETF + ubiquinol." [EC:1.5.5.1] subset: gosubset_prok synonym: "electron transfer flavoprotein dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein Q oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein reductase activity" EXACT [EC:1.5.5.1] synonym: "electron transfer flavoprotein-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "electron-transferring-flavoprotein:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF dehydrogenase activity" EXACT [EC:1.5.5.1] synonym: "ETF-QO activity" EXACT [EC:1.5.5.1] synonym: "ETF-ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] synonym: "ETF:ubiquinone oxidoreductase activity" EXACT [EC:1.5.5.1] xref: EC:1.5.5.1 xref: MetaCyc:1.5.5.1-RXN xref: Reactome:8494 "electron-transferring-flavoprotein dehydrogenase activity" is_a: GO:0016649 ! oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor [Term] id: GO:0004175 name: endopeptidase activity namespace: molecular_function alt_id: GO:0016809 def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain." [http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "endoprotease activity" EXACT [] synonym: "proteasome endopeptidase activity" NARROW [] synonym: "proteinase" BROAD [] xref: Reactome:1793 "endopeptidase activity" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004176 name: ATP-dependent peptidase activity namespace: molecular_function alt_id: GO:0004280 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the hydrolysis of peptide bonds." [GOC:mah] subset: gosubset_prok synonym: "ATP-dependent proteolysis" RELATED [GOC:mah] is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0004177 name: aminopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal amino acid residues from in a polypeptide chain." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.11 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004178 name: leucyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb-, in which Xaa is preferably Leu, but may be other amino acids including Pro although not Arg or Lys, and Xbb may be Pro." [EC:3.4.11.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase II" RELATED [EC:3.4.11.1] synonym: "cathepsin III" RELATED [EC:3.4.11.1] synonym: "cytosol aminopeptidase activity" NARROW [EC:3.4.11.1] synonym: "FTBL proteins" RELATED [EC:3.4.11.1] synonym: "L-leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinamide aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucinaminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucine aminopeptidase activity" EXACT [EC:3.4.11.1] synonym: "leucyl peptidase activity" EXACT [EC:3.4.11.1] synonym: "peptidase S activity" NARROW [EC:3.4.11.1] synonym: "proteinates FTBL" RELATED [EC:3.4.11.1] xref: EC:3.4.11.1 xref: MetaCyc:3.4.11.1-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004179 name: membrane alanyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, Xaa-Xbb- from a peptide, amide or arylamide. Xaa is preferably Ala, but may be most amino acids including Pro (slow action). When a terminal hydrophobic residue is followed by a prolyl residue, the two may be released as an intact Xaa-Pro dipeptide." [EC:3.4.11.2] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alanine-specific aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "alanyl aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "amino-oligopeptidase activity" EXACT [EC:3.4.11.2] synonym: "aminopeptidase M activity" NARROW [EC:3.4.11.2] synonym: "aminopeptidase N activity" NARROW [EC:3.4.11.2] synonym: "CD13" RELATED [EC:3.4.11.2] synonym: "cysteinylglycinase activity" EXACT [EC:3.4.11.2] synonym: "cysteinylglycine dipeptidase activity" EXACT [EC:3.4.11.2] synonym: "L-alanine aminopeptidase activity" EXACT [EC:3.4.11.2] synonym: "membrane alanine aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "membrane aminopeptidase I activity" NARROW [EC:3.4.11.2] synonym: "microsomal aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "particle-bound aminopeptidase activity" NARROW [EC:3.4.11.2] synonym: "peptidase E activity" BROAD [EC:3.4.11.2] synonym: "pseudo leucine aminopeptidase activity" EXACT [EC:3.4.11.2] xref: EC:3.4.11.2 xref: MetaCyc:3.4.11.2-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004180 name: carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal or penultimate peptide bond at the C-terminal end of a peptide or polypeptide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0004181 name: metallocarboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of C-terminal amino acid residues from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.4.17 xref: Reactome:8516 "metallocarboxypeptidase activity" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0008235 ! metalloexopeptidase activity [Term] id: GO:0004182 name: carboxypeptidase A activity namespace: molecular_function alt_id: GO:0008731 def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-amino acid + H2O = peptide + L-amino acid. Little or no action with -Asp, -Glu, -Arg, -Lys or -Pro." [EC:3.4.17.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "carboxypolypeptidase activity" EXACT [EC:3.4.17.1] synonym: "pancreatic carboxypeptidase A" RELATED [EC:3.4.17.1] synonym: "tissue carboxypeptidase A" RELATED [EC:3.4.17.1] xref: EC:3.4.17.1 xref: MetaCyc:CARBOXYPEPTIDASE-A-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004183 name: carboxypeptidase E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+ and inhibited by 1,10-phenanthroline and other chelating agents." [EC:3.4.17.10] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase H activity" EXACT [] synonym: "cobalt-stimulated chromaffin granule carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin convertase activity" NARROW [EC:3.4.17.10] synonym: "enkephalin precursor carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "enkephalin-precursor endopeptidase activity" EXACT [EC:3.4.17.10] synonym: "insulin granule-associated carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "membrane-bound carboxypeptidase activity" EXACT [EC:3.4.17.10] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.10] xref: EC:3.4.17.10 xref: MetaCyc:CARBOXYPEPTIDASE-H-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004184 name: lysine carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Release of a C-terminal basic amino acid, preferentially lysine; inactivates bradykinin and anaphylatoxins in blood plasma." [EC:3.4.17.3] comment: This term was made obsolete because it represents a gene product. synonym: "anaphylatoxin inactivator activity" NARROW [EC:3.4.17.3] synonym: "arginine carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "bradykinase activity" EXACT [EC:3.4.17.3] synonym: "bradykinin-decomposing enzyme" RELATED [EC:3.4.17.3] synonym: "carboxypeptidase N activity" EXACT [] synonym: "CPase N" RELATED [EC:3.4.17.3] synonym: "creatine kinase conversion factor" RELATED [EC:3.4.17.3] synonym: "creatinine kinase convertase activity" EXACT [EC:3.4.17.3] synonym: "hippuryllysine hydrolase activity" EXACT [EC:3.4.17.3] synonym: "kininase I activity" EXACT [EC:3.4.17.3] synonym: "kininase Ia" RELATED [EC:3.4.17.3] synonym: "lysine (arginine) carboxypeptidase activity" EXACT [] synonym: "lysine(arginine) carboxypeptidase activity" EXACT [EC:3.4.17.3] synonym: "peptidyl-L-lysine(-L-arginine) hydrolase" BROAD [EC:3.4.17.3] synonym: "plasma carboxypeptidase B" RELATED [EC:3.4.17.3] xref: EC:3.4.17.3 xref: MetaCyc:LYSINEARGININE-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004185 name: serine-type carboxypeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the C-terminus of a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CARBOXYPEPTIDASE, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "serine carboxypeptidase activity" EXACT [] xref: EC:3.4.16 xref: Reactome:8533 "serine-type carboxypeptidase activity" is_a: GO:0004180 ! carboxypeptidase activity is_a: GO:0070008 ! serine-type exopeptidase activity [Term] id: GO:0004186 name: carboxypeptidase C activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase Y activity" EXACT [EC:3.4.16.5] synonym: "cathepsin A activity" NARROW [EC:3.4.16.5] synonym: "deamidase" RELATED [EC:3.4.16.5] synonym: "lysosomal carboxypeptidase A" NARROW [EC:3.4.16.5] synonym: "lysosomal protective protein activity" NARROW [EC:3.4.16.5] synonym: "serine carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "serine-type carboxypeptidase I activity" EXACT [EC:3.4.16.5] synonym: "vacuolar carboxypeptidase Y" NARROW [] xref: EC:3.4.16.5 xref: MetaCyc:3.4.16.5-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004187 name: carboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential release of a C-terminal arginine or lysine residue. Function is inhibited by diisopropyl fluorophosphate and sensitive to thiol-blocking reagents." [EC:3.4.16.6] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase Kex1" RELATED [EC:3.4.16.6] synonym: "carboxypeptidase KEX1 activity" NARROW [EC:3.4.16.6] synonym: "carboxypeptidase S1 activity" EXACT [EC:3.4.16.6] synonym: "cereal serine carboxypeptidase II" RELATED [EC:3.4.16.6] synonym: "CPDW-II" RELATED [EC:3.4.16.6] synonym: "gene KEX1 serine carboxypeptidase" NARROW [EC:3.4.16.6] synonym: "KEX1 carboxypeptidase activity" EXACT [EC:3.4.16.6] synonym: "KEX1 proteinase activity" EXACT [EC:3.4.16.6] synonym: "KEX1DELTAp" RELATED [EC:3.4.16.6] synonym: "saccharomyces cerevisiae KEX1 gene product" RELATED [EC:3.4.16.6] xref: EC:3.4.16.6 xref: MetaCyc:3.4.16.6-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004188 name: serine-type Pro-X carboxypeptidase activity namespace: molecular_function alt_id: GO:0008323 def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond by a serine-type peptidase mechanism to release a C-terminal amino acid." [EC:3.4.16.2] comment: This term was made obsolete because it represents a gene product. synonym: "aminoacylproline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "angiotensinase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal carboxypeptidase C activity" NARROW [EC:3.4.16.2] synonym: "lysosomal Pro-X carboxypeptidase activity" NARROW [] synonym: "lysosomal Pro-Xaa carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "PCP" RELATED [EC:3.4.16.2] synonym: "peptidylprolylamino acid carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline carboxypeptidase activity" EXACT [EC:3.4.16.2] synonym: "proline-specific carboxypeptidase P" RELATED [EC:3.4.16.2] synonym: "prolyl carboxypeptidase activity" EXACT [EC:3.4.16.2] xref: EC:3.4.16.2 xref: MetaCyc:3.4.16.2-RXN is_obsolete: true replaced_by: GO:0004185 [Term] id: GO:0004189 name: tubulinyl-Tyr carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Glu-Tyr bond to release the C-terminal tyrosine residue from the native tyrosinated tubulin. Inactive on Z-Glu-Tyr." [EC:3.4.17.17] comment: This term was made obsolete because it represents a gene product. synonym: "brain I carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "carboxypeptidase-tubulin activity" EXACT [EC:3.4.17.17] synonym: "soluble carboxypeptidase activity" RELATED [EC:3.4.17.17] synonym: "TTCPase activity" EXACT [EC:3.4.17.17] synonym: "tubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulin-tyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tubulinyl-tyrosine carboxypeptidase activity" EXACT [] synonym: "tubulinyltyrosine carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosinotubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] synonym: "tyrosyltubulin carboxypeptidase activity" EXACT [EC:3.4.17.17] xref: EC:3.4.17.17 xref: MetaCyc:3.4.17.17-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004190 name: aspartic-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartic endopeptidase activity" EXACT [] synonym: "aspartic protease activity" EXACT [] synonym: "aspartyl protease activity" EXACT [] synonym: "carboxyl protease activity" EXACT [] xref: EC:3.4.23 xref: Reactome:1933 "aspartic-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070001 ! aspartic-type peptidase activity [Term] id: GO:0004191 name: barrierpepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selected cleavage of the Leu6-Lys7 bond in the pheromone alpha-mating factor." [EC:3.4.23.35] comment: This term was made obsolete because it represents a gene product. synonym: "Bar proteinase activity" NARROW [EC:3.4.23.35] synonym: "barrier proteinase activity" EXACT [EC:3.4.23.35] synonym: "extracellular 'barrier' protein activity" RELATED [EC:3.4.23.35] xref: EC:3.4.23.35 xref: MetaCyc:3.4.23.35-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004192 name: cathepsin D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to, but narrower than, that of pepsin A. Does not cleave the Gln4-His5 bond in the B chain of insulin." [EC:3.4.23.5] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.23.5 xref: MetaCyc:3.4.23.5-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004193 name: cathepsin E activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin D, but slightly broader specificity." [EC:3.4.23.34] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin D-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin D-type proteinase activity" EXACT [EC:3.4.23.34] synonym: "cathepsin E-like acid proteinase activity" EXACT [EC:3.4.23.34] synonym: "EMAP" RELATED [EC:3.4.23.34] synonym: "erythrocyte membrane aspartic proteinase activity" NARROW [EC:3.4.23.34] synonym: "non-pepsin proteinase activity" EXACT [EC:3.4.23.34] synonym: "slow-moving proteinase activity" RELATED [EC:3.4.23.34] synonym: "SMP" RELATED [EC:3.4.23.34] xref: EC:3.4.23.34 xref: MetaCyc:3.4.23.34-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004194 name: pepsin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Preferential cleavage: hydrophobic, preferably aromatic, residues in P1 and P1' positions. Cleaves Phe1-Val2, Gln4-His5, Glu13-Ala14, Ala14-Leu15, Leu15-Tyr16, Tyr16-Leu17, Gly23-Phe24, Phe24-Phe25 and Phe25-Tyr26 bonds in the B chain of insulin." [EC:3.4.23.1] comment: This term was made obsolete because it represents a gene product. synonym: "elixir lactate of pepsin" RELATED [EC:3.4.23.1] synonym: "fundus-pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin" RELATED [EC:3.4.23.1] synonym: "lactated pepsin elixir" RELATED [EC:3.4.23.1] synonym: "P I" RELATED [EC:3.4.23.1] synonym: "P II" RELATED [EC:3.4.23.1] synonym: "pepsin activity" BROAD [EC:3.4.23.1] synonym: "pepsin D" RELATED [EC:3.4.23.1] synonym: "pepsin fortior" RELATED [EC:3.4.23.1] synonym: "pepsin R" RELATED [EC:3.4.23.1] xref: EC:3.4.23.1 xref: MetaCyc:3.4.23.1-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004195 name: renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Leu-Xaa bond in angiotensinogen to generate angiotensin I." [EC:3.4.23.15] comment: This term was made obsolete because it represents a gene product. synonym: "angiotensin-forming enzyme activity" EXACT [EC:3.4.23.15] synonym: "angiotensinogenase activity" EXACT [EC:3.4.23.15] xref: EC:3.4.23.15 xref: MetaCyc:3.4.23.15-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004196 name: saccharopepsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of gelatin; little activity on hemoglobin. Specificity on B chain of insulin more restricted than pepsin A; does not cleave Phe1-Val2, Gln4-His5 or Gly23-Phe24." [EC:3.4.23.25] comment: This term was made obsolete because it represents a gene product. synonym: "aspartic proteinase yscA" RELATED [EC:3.4.23.25] synonym: "PRA" RELATED [EC:3.4.23.25] synonym: "proteinase A" RELATED [EC:3.4.23.25] synonym: "proteinase yscA" RELATED [EC:3.4.23.25] synonym: "saccharomyces aspartic proteinase activity" EXACT [EC:3.4.23.25] synonym: "Saccharomyces aspartic proteinase activity" NARROW [EC:3.4.23.25] synonym: "saccharomyces cerevisiae aspartic proteinase A" RELATED [EC:3.4.23.25] synonym: "yeast endopeptidase A activity" NARROW [EC:3.4.23.25] synonym: "yeast proteinase A" RELATED [EC:3.4.23.25] xref: EC:3.4.23.25 xref: MetaCyc:3.4.23.25-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0004197 name: cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "lysosomal cysteine-type endopeptidase" NARROW [] synonym: "thiol endopeptidase activity" EXACT [] xref: EC:3.4.22 xref: Reactome:4344 "cysteine-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004198 name: calcium-dependent cysteine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium." [GOC:mah] subset: gosubset_prok synonym: "calpain activity" NARROW [] is_a: GO:0004197 ! cysteine-type endopeptidase activity [Term] id: GO:0004200 name: signaling (initiator) caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. synonym: "signalling (initiator) caspase activity" EXACT [] is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004201 name: caspase-1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of interleukin 1-beta by specific cleavage of Asp116-Ala117 and Asp27-Gly28 bonds in precursor. Enzymes with this function can also hydrolyze the terminal bond in the small-molecule substrate, Ac-Tyr-Val-Ala-Asp-NHMec." [EC:3.4.22.36] comment: This term was made obsolete because it represents a gene product. synonym: "ICE" BROAD [] is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004202 name: caspase-2 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004203 name: caspase-4 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004204 name: caspase-5 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004205 name: caspase-8 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004206 name: caspase-10 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004207 name: effector caspase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes biological process information. is_obsolete: true replaced_by: GO:0004197 consider: GO:0006915 [Term] id: GO:0004208 name: caspase-3 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at the terminal bond of the motif: Asp-Xaa-Xaa-Asp-Xaa. Enzymes with this function are members of the peptidase family C14 and they appear to function in the inactivation of proteins involved in cellular repair and homeostasis during the effector stage of apoptosis." [ISBN:0120793709] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004209 name: caspase-6 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004210 name: caspase-7 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004211 name: caspase-9 activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004212 name: lysosomal cysteine-type endopeptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0004197 consider: GO:0005764 [Term] id: GO:0004213 name: cathepsin B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds with a broad specificity. Preferentially cleaves the terminal bond of -Arg-Arg-Xaa motifs in small molecule substrates (thus differing from cathepsin L). In addition to being an endopeptidase, shows peptidyl-dipeptidase activity, liberating C-terminal dipeptides." [EC:3.4.22.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin B1 activity" EXACT [EC:3.4.22.1] synonym: "cathepsin II" RELATED [EC:3.4.22.1] xref: EC:3.4.22.1 xref: MetaCyc:3.4.22.1-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004214 name: dipeptidyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, Xaa-Xbb from Xaa-Xbb-Xcc, except when Xaa is Arg or Lys, or Xbb or Xcc is Pro." [EC:3.4.14.1] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin C activity" EXACT [EC:3.4.14.1] synonym: "cathepsin J activity" EXACT [EC:3.4.14.1] synonym: "DAP I" RELATED [EC:3.4.14.1] synonym: "dipeptide arylamidase I" RELATED [EC:3.4.14.1] synonym: "dipeptidyl aminopeptidase I activity" EXACT [EC:3.4.14.1] synonym: "dipeptidyl transferase activity" EXACT [EC:3.4.14.1] xref: EC:3.4.14.1 xref: MetaCyc:3.4.14.1-RXN is_obsolete: true replaced_by: GO:0008234 replaced_by: GO:0008239 [Term] id: GO:0004215 name: cathepsin H activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds, acting as an aminopeptidase (notably, cleaving Arg-Xaa bonds) as well as an endopeptidase." [EC:3.4.22.16] comment: This term was made obsolete because it represents a gene product. synonym: "aleurain activity" EXACT [EC:3.4.22.16] synonym: "benzoylarginine-naphthylamide (BANA) hydrolase activity" EXACT [EC:3.4.22.16] synonym: "cathepsin B3 activity" EXACT [EC:3.4.22.16] synonym: "cathepsin Ba" RELATED [EC:3.4.22.16] synonym: "cathepsin BA activity" EXACT [EC:3.4.22.16] synonym: "N-benzoylarginine-beta-naphthylamide hydrolase activity" EXACT [EC:3.4.22.16] xref: EC:3.4.22.16 xref: MetaCyc:3.4.22.16-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004216 name: cathepsin K activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Has a broad proteolytic activity. With small-molecule substrates and inhibitors, the major determinant of specificity is P2, which is preferably Leu, Met > Phe, and not Arg." [EC:3.4.22.38] comment: This term was made obsolete because it represents a gene product. synonym: "cathepsin O activity" EXACT [EC:3.4.22.38] synonym: "cathepsin O2 activity" EXACT [EC:3.4.22.38] synonym: "cathepsin X activity" EXACT [EC:3.4.22.38] xref: EC:3.4.22.38 xref: MetaCyc:3.4.22.38-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004217 name: cathepsin L activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity close to that of papain. As compared to cathepsin B, cathepsin L exhibits higher activity towards protein substrates, but has little activity on Z-Arg-Arg-NHMec, and no peptidyl-dipeptidase activity." [EC:3.4.22.15] comment: This term was made obsolete because it represents a gene product. synonym: "Aldrichina grahami cysteine proteinase" NARROW [EC:3.4.22.15] xref: EC:3.4.22.15 xref: MetaCyc:3.4.22.15-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004218 name: cathepsin S activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Similar to cathepsin L, but with much less activity on the terminal bond of Z-Phe-Arg-NHMec, and more activity on the terminal bond of Z-Val-Val-Arg-Xaa compounds." [EC:3.4.22.27] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.22.27 xref: MetaCyc:3.4.22.27-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0004219 name: pyroglutamyl-peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: pyroglutamyl-peptide + H2O = pyroglutamate + peptide." [EC:3.4.19.3] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "5-oxoprolyl-peptidase activity" EXACT [EC:3.4.19.3] synonym: "L-pyroglutamyl peptide hydrolase activity" EXACT [EC:3.4.19.3] synonym: "L-pyrrolidonecarboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrase activity" EXACT [EC:3.4.19.3] synonym: "PYRase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamate aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamidase activity" EXACT [EC:3.4.19.3] synonym: "pyroglutamyl aminopeptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidone-carboxylate peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonecarboxylyl peptidase activity" EXACT [EC:3.4.19.3] synonym: "pyrrolidonyl peptidase activity" EXACT [EC:3.4.19.3] xref: EC:3.4.19.3 xref: MetaCyc:PYROGLUTAMYL-PEPTIDASE-I-RXN is_obsolete: true replaced_by: GO:0008234 replaced_by: GO:0016920 [Term] id: GO:0004221 name: ubiquitin thiolesterase activity namespace: molecular_function alt_id: GO:0008577 def: "Catalysis of the reaction: ubiquitin C-terminal thiolester + H2O = ubiquitin + a thiol. Hydrolysis of esters, including those formed between thiols such as dithiothreitol or glutathione and the C-terminal glycine residue of the polypeptide ubiquitin, and AMP-ubiquitin." [EC:3.1.2.15] comment: Note that this term is distinguished from 'ubiquitin-specific protease activity ; GO:0004843' in that it specifically refers to hydrolysis of thiolester bonds, but encompasses the removal of any substrate attached to ubiquitin via a thiolester bond. subset: gosubset_prok synonym: "ubiquitin C-terminal hydrolase activity" RELATED [] synonym: "ubiquitin carboxy-terminal esterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin carboxy-terminal hydrolase activity" RELATED [EC:3.1.2.15] synonym: "ubiquitin thioesterase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitin-C-terminal-thioester hydrolase activity" EXACT [EC:3.1.2.15] synonym: "ubiquitinyl hydrolase 1 activity" NARROW [] xref: EC:3.1.2.15 xref: MetaCyc:UBIQUITIN-THIOLESTERASE-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004222 name: metalloendopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "metalloendoprotease activity" EXACT [GOC:mah] synonym: "metalloendoproteinase activity" EXACT [GOC:mah] xref: EC:3.4.24 xref: Reactome:1791 "metalloendopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008237 ! metallopeptidase activity [Term] id: GO:0004226 name: Gly-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-Gly-Xaa + H2O = peptidyl-Gly + Xaa." [EC:3.4.17.4] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "carboxypeptidase a" RELATED [EC:3.4.17.4] synonym: "carboxypeptidase S activity" EXACT [EC:3.4.17.4] synonym: "Gly-Xaa carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "glycine carboxypeptidase activity" EXACT [EC:3.4.17.4] synonym: "peptidase alpha" RELATED [EC:3.4.17.4] synonym: "yeast carboxypeptidase activity" EXACT [EC:3.4.17.4] xref: EC:3.4.17.4 xref: MetaCyc:GLY-X-CARBOXYPEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0004228 name: gelatinase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin type I and collagen types IV, V, VII, X. Cleaves the collagen-like sequence Pro-Gln-Gly-Ile-Ala-Gly-Gln at the Gly-Ile bond." [EC:3.4.24.24] comment: This term was made obsolete because it represents a gene product. synonym: "3/4 collagenase activity" EXACT [EC:3.4.24.24] synonym: "72 kDa gelatinase type A" RELATED [EC:3.4.24.24] synonym: "72-kDa gelatinase activity" NARROW [EC:3.4.24.24] synonym: "collagenase IV" RELATED [EC:3.4.24.24] synonym: "collagenase type IV" RELATED [EC:3.4.24.24] synonym: "matrix metalloproteinase 2 activity" EXACT [EC:3.4.24.24] synonym: "matrix metalloproteinase 5" RELATED [EC:3.4.24.24] synonym: "MMP 2" RELATED [EC:3.4.24.24] synonym: "MMP-2" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.24] synonym: "type IV collagenase activity" EXACT [EC:3.4.24.24] synonym: "type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.24] xref: EC:3.4.24.24 xref: MetaCyc:3.4.24.24-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004229 name: gelatinase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of gelatin types I and V and collagen types IV and V." [EC:3.4.24.35] comment: This term was made obsolete because it represents a gene product. synonym: "92-kDa gelatinase activity" NARROW [EC:3.4.24.35] synonym: "92-kDa type IV collagenase activity" NARROW [EC:3.4.24.35] synonym: "95 kDa type IV collagenase/gelatinase activity" EXACT [EC:3.4.24.35] synonym: "collagenase IV" RELATED [EC:3.4.24.35] synonym: "collagenase type IV" RELATED [EC:3.4.24.35] synonym: "gelatinase MMP 9" RELATED [EC:3.4.24.35] synonym: "macrophage gelatinase activity" NARROW [EC:3.4.24.35] synonym: "matrix metalloproteinase 9 activity" EXACT [EC:3.4.24.35] synonym: "MMP 9" RELATED [EC:3.4.24.35] synonym: "MMP-9" EXACT [] synonym: "type IV collagen metalloproteinase" BROAD [EC:3.4.24.35] synonym: "type V collagenase activity" EXACT [EC:3.4.24.35] xref: EC:3.4.24.35 xref: MetaCyc:3.4.24.35-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004230 name: glutamyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a N-terminal glutamate (and to a lesser extent aspartate) from a peptide." [EC:3.4.11.7] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A" RELATED [EC:3.4.11.7] synonym: "angiotensinase A2" RELATED [EC:3.4.11.7] synonym: "antigen BP-1/6C3 of mouse B lymphocytes" RELATED [EC:3.4.11.7] synonym: "aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "Ca2+-activated glutamate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "glutamyl peptidase activity" EXACT [EC:3.4.11.7] synonym: "L-aspartate aminopeptidase activity" EXACT [EC:3.4.11.7] synonym: "membrane aminopeptidase II" RELATED [EC:3.4.11.7] xref: EC:3.4.11.7 xref: MetaCyc:3.4.11.7-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004231 name: insulysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the degradation of insulin, glucagon and other polypeptides. No action on proteins." [EC:3.4.24.56] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "IDE" RELATED [EC:3.4.24.56] synonym: "insulin protease activity" EXACT [EC:3.4.24.56] synonym: "insulin proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading enzyme activity" EXACT [EC:3.4.24.56] synonym: "insulin-degrading neutral proteinase activity" EXACT [EC:3.4.24.56] synonym: "insulin-glucagon protease activity" EXACT [EC:3.4.24.56] synonym: "insulin-specific protease activity" EXACT [EC:3.4.24.56] synonym: "insulinase activity" EXACT [EC:3.4.24.56] synonym: "metalloinsulinase activity" EXACT [EC:3.4.24.56] xref: EC:3.4.24.56 xref: MetaCyc:3.4.24.56-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004232 name: interstitial collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of one bond in native collagen. Cleavage of the triple helix of collagen at about three-quarters of the length of the molecule from the N-terminus, at Gly775-Ile776 in the alpha-1(I) chain. Cleaves synthetic substrates and alpha-macroglobulins at bonds where P1' is a hydrophobic residue." [EC:3.4.24.7] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 1" EXACT [] synonym: "MMP-1" EXACT [] synonym: "vertebrate collagenase activity" EXACT [EC:3.4.24.7] xref: EC:3.4.24.7 xref: MetaCyc:3.4.24.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004234 name: macrophage elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of soluble and insoluble elastin. Specific cleavages are also produced at Ala14-Leu15 and Tyr16-Leu17 in the B chain of insulin." [EC:3.4.24.65] comment: This term was made obsolete because it represents a gene product. synonym: "human macrophage metalloelastase (HME)" EXACT [EC:3.4.24.65] synonym: "matrix metalloproteinase 12 activity" EXACT [EC:3.4.24.65] synonym: "metalloelastase activity" EXACT [EC:3.4.24.65] synonym: "metalloesterase activity" EXACT [] synonym: "MMP-12" EXACT [] xref: EC:3.4.24.65 xref: MetaCyc:3.4.24.65-RXN is_obsolete: true replaced_by: GO:0004175 replaced_by: GO:0004222 [Term] id: GO:0004235 name: matrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Ala14-Leu15 and Tyr16-Leu17 in B chain of insulin. No action on collagen types I, II, IV and V. Cleaves gelatin chain alpha-2(I) > alpha-1(I)." [EC:3.4.24.23] comment: This term was made obsolete because it represents a gene product. synonym: "matrin activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase 7 activity" EXACT [EC:3.4.24.23] synonym: "matrix metalloproteinase pump 1" RELATED [EC:3.4.24.23] synonym: "metalloproteinase pump-1" RELATED [EC:3.4.24.23] synonym: "MMP" RELATED [EC:3.4.24.23] synonym: "MMP 7" RELATED [EC:3.4.24.23] synonym: "MMP-7" EXACT [] synonym: "PUMP" RELATED [EC:3.4.24.23] synonym: "PUMP-1 activity" NARROW [EC:3.4.24.23] synonym: "PUMP-1 proteinase activity" EXACT [EC:3.4.24.23] synonym: "putative (or punctuated) metalloproteinase-1 activity" NARROW [EC:3.4.24.23] synonym: "putative metalloproteinase activity" EXACT [EC:3.4.24.23] synonym: "uterine metalloendopeptidase activity" NARROW [EC:3.4.24.23] xref: EC:3.4.24.23 xref: MetaCyc:3.4.24.23-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004237 name: membrane dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of dipeptides." [EC:3.4.13.19] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminodipeptidase activity" EXACT [EC:3.4.13.19] synonym: "dehydropeptidase I (DPH I)" RELATED [EC:3.4.13.19] synonym: "dehydropeptidase I activity" EXACT [EC:3.4.13.19] synonym: "dipeptide hydrolase" BROAD [EC:3.4.13.19] synonym: "dipeptidyl hydrolase activity" EXACT [EC:3.4.13.19] synonym: "DPH I activity" NARROW [EC:3.4.13.19] synonym: "glycosyl-phosphatidylinositol-anchored renal dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "MDP" RELATED [EC:3.4.13.19] synonym: "microsomal dipeptidase activity" NARROW [EC:3.4.13.19] synonym: "nonspecific dipeptidase activity" EXACT [EC:3.4.13.19] synonym: "renal dipeptidase activity" NARROW [EC:3.4.13.19] xref: EC:3.4.13.19 xref: MetaCyc:3.4.13.19-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0004238 name: meprin A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of protein and peptide substrates preferentially on carboxyl side of hydrophobic residues." [EC:3.4.24.18] comment: This term was made obsolete because it represents a gene product. synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.18] synonym: "meprin" RELATED [EC:3.4.24.18] synonym: "meprin-a" RELATED [EC:3.4.24.18] synonym: "N-benzoyl-L-tyrosyl-p-aminobenzoic acid hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PABA-peptide hydrolase activity" EXACT [EC:3.4.24.18] synonym: "PPH" RELATED [EC:3.4.24.18] xref: EC:3.4.24.18 xref: MetaCyc:3.4.24.18-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004239 name: methionyl aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal amino acids, preferentially methionine, from peptides and arylamides." [EC:3.4.11.18] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "L-methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "MAP" RELATED [EC:3.4.11.18] synonym: "methionine aminopeptidase activity" EXACT [EC:3.4.11.18] synonym: "peptidase M activity" EXACT [EC:3.4.11.18] xref: EC:3.4.11.18 xref: MetaCyc:3.4.11.18-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 consider: GO:0070084 [Term] id: GO:0004240 name: mitochondrial processing peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal transit peptides from precursor proteins imported into the mitochondrion, typically with Arg in position P2." [EC:3.4.24.64] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-mitochondrial processing peptidase" NARROW [] synonym: "beta-mitochondrial processing peptidase" NARROW [] synonym: "matrix peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing peptidase" RELATED [EC:3.4.24.64] synonym: "matrix processing proteinase" RELATED [EC:3.4.24.64] synonym: "mitochondrial protein precursor-processing proteinase activity" EXACT [EC:3.4.24.64] synonym: "MPP" EXACT [] synonym: "processing enhancing peptidase (for one of two subunits)" RELATED [EC:3.4.24.64] synonym: "processing enhancing peptidase activity" NARROW [EC:3.4.24.64] xref: EC:3.4.24.64 xref: MetaCyc:3.4.24.64-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004241 name: alpha-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "alpha-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004242 name: beta-mitochondrial processing peptidase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "beta-MPP" EXACT [] is_obsolete: true consider: GO:0004222 consider: GO:0005739 [Term] id: GO:0004243 name: mitochondrial intermediate peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal octapeptide as second stage of processing of some proteins imported in the mitochondrion." [EC:3.4.24.59] comment: This term was made obsolete because it represents a gene product. synonym: "MIP" BROAD [] synonym: "mitochondrial intermediate precursor-processing proteinase activity" EXACT [EC:3.4.24.59] xref: EC:3.4.24.59 xref: MetaCyc:3.4.24.59-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004244 name: mitochondrial inner membrane peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the maturation of mitochondrial precursor proteins delivered to the intermembrane space." [PMID:12191769] comment: This term was made obsolete because it represents a gene product. synonym: "IMP" BROAD [] xref: EC:3.4.99.- is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0004245 name: neprilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage at the amino group of hydrophobic residues in insulin, casein, hemoglobin, and a number of other proteins and polypeptides." [EC:3.4.24.11] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "CALLA" RELATED [EC:3.4.24.11] synonym: "CALLA (common acute lymphoblastic leukemia-associated) antigens" RELATED [EC:3.4.24.11] synonym: "CALLA antigen" RELATED [EC:3.4.24.11] synonym: "CALLA glycoprotein" RELATED [EC:3.4.24.11] synonym: "CALLA glycoproteins" RELATED [EC:3.4.24.11] synonym: "CD10" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia antigen" RELATED [EC:3.4.24.11] synonym: "common acute lymphoblastic leukemia-associated antigens" RELATED [EC:3.4.24.11] synonym: "endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "endopeptidase-2 activity" BROAD [EC:3.4.24.11] synonym: "enkephalinase activity" EXACT [EC:3.4.24.11] synonym: "kidney-brush-border neutral endopeptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral peptidase" NARROW [EC:3.4.24.11] synonym: "kidney-brush-border neutral proteinase activity" NARROW [EC:3.4.24.11] synonym: "membrane metalloendopeptidase activity" NARROW [EC:3.4.24.11] synonym: "neutral endopeptidase 24.11" RELATED [EC:3.4.24.11] synonym: "neutral endopeptidase activity" EXACT [EC:3.4.24.11] synonym: "neutral metallendopeptidase activity" EXACT [EC:3.4.24.11] xref: EC:3.4.24.11 xref: MetaCyc:3.4.24.11-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004246 name: peptidyl-dipeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal dipeptide, Xaa-Xbb from oligopeptide-Xaa-Xbb, when Xaa is not Pro, and Xbb is neither Asp nor Glu. Converts angiotensin I to angiotensin II." [EC:3.4.15.1] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ACE activity" BROAD [] synonym: "angiotensin converting enzyme" RELATED [EC:3.4.15.1] synonym: "angiotensin I-converting enzyme activity" EXACT [EC:3.4.15.1] synonym: "carboxycathepsin activity" EXACT [EC:3.4.15.1] synonym: "DCP" RELATED [EC:3.4.15.1] synonym: "dipeptide hydrolase" BROAD [EC:3.4.15.1] synonym: "dipeptidyl carboxypeptidase I activity" EXACT [EC:3.4.15.1] synonym: "endothelial cell peptidyl dipeptidase activity" EXACT [EC:3.4.15.1] synonym: "kininase II activity" EXACT [EC:3.4.15.1] synonym: "PDH" RELATED [EC:3.4.15.1] synonym: "peptidase P activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase A" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptidase I activity" EXACT [EC:3.4.15.1] synonym: "peptidyl dipeptidase-4" RELATED [EC:3.4.15.1] synonym: "peptidyl dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyl-dipeptide hydrolase activity" EXACT [EC:3.4.15.1] synonym: "peptidyldipeptide hydrolase activity" EXACT [EC:3.4.15.1] xref: EC:3.4.15.1 xref: MetaCyc:3.4.15.1-RXN is_obsolete: true replaced_by: GO:0008237 replaced_by: GO:0008241 [Term] id: GO:0004247 name: saccharolysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of Pro-Phe and Ala-Ala bonds." [EC:3.4.24.37] comment: This term was made obsolete because it represents a gene product. synonym: "oligopeptidase yscD activity" NARROW [EC:3.4.24.37] synonym: "proteinase yscD activity" NARROW [EC:3.4.24.37] synonym: "saccharomyces cerevisiae proteinase yscD" RELATED [EC:3.4.24.37] synonym: "yeast cysteine proteinase D activity" NARROW [EC:3.4.24.37] xref: EC:3.4.24.37 xref: MetaCyc:3.4.24.37-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004248 name: stromelysin 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage where P1', P2' and P3' are hydrophobic residues." [EC:3.4.24.17] comment: This term was made obsolete because it represents a gene product. synonym: "collagen-activating protein" RELATED [EC:3.4.24.17] synonym: "collagenase activating protein" RELATED [EC:3.4.24.17] synonym: "matrix metalloproteinase 3 activity" EXACT [EC:3.4.24.17] synonym: "MMP-3" EXACT [] synonym: "neutral proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "procollagenase activator" RELATED [EC:3.4.24.17] synonym: "proteoglycanase activity" EXACT [EC:3.4.24.17] synonym: "stromelysin" RELATED [EC:3.4.24.17] synonym: "transin activity" EXACT [EC:3.4.24.17] xref: EC:3.4.24.17 xref: MetaCyc:3.4.24.17-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004249 name: stromelysin 3 activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 11" EXACT [] synonym: "MMP-11" EXACT [] xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0004250 name: aminopeptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal amino acid, preferably a neutral or hydrophobic one, from a polypeptide. Aminoacyl-arylamides are poor substrates." [EC:3.4.11.22] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase III activity" EXACT [EC:3.4.11.22] synonym: "aminopeptidase yscI activity" NARROW [EC:3.4.11.22] synonym: "leucine aminopeptidase IV activity" EXACT [EC:3.4.11.22] synonym: "vacuolar aminopeptidase I activity" NARROW [EC:3.4.11.22] synonym: "yeast aminopeptidase I" RELATED [EC:3.4.11.22] xref: EC:3.4.11.22 xref: MetaCyc:3.4.11.22-RXN is_obsolete: true replaced_by: GO:0004177 replaced_by: GO:0008235 [Term] id: GO:0004251 name: X-Pro dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-Pro dipeptides; also acts on aminoacyl-hydroxyproline analogs. No action on Pro-Pro." [EC:3.4.13.9] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "gamma-peptidase activity" EXACT [EC:3.4.13.9] synonym: "imidodipeptidase activity" EXACT [EC:3.4.13.9] synonym: "peptidase D" RELATED [EC:3.4.13.9] synonym: "prolidase activity" EXACT [EC:3.4.13.9] synonym: "proline dipeptidase activity" EXACT [EC:3.4.13.9] synonym: "Xaa-Pro dipeptidase activity" EXACT [] xref: EC:3.4.13.9 xref: MetaCyc:3.4.13.9-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0004252 name: serine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "blood coagulation factor activity" RELATED [] xref: EC:3.4.21 xref: Reactome:1683 "serine-type endopeptidase activity" is_a: GO:0004175 ! endopeptidase activity is_a: GO:0008236 ! serine-type peptidase activity [Term] id: GO:0004253 name: gamma-renin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Leu-Leu bond in synthetic tetradecapeptide renin substrate, producing angiotensin I, but not active on natural angiotensinogen. Also hydrolyzes BZ-Arg-para-nitroanilide." [EC:3.4.21.54] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.21.54 xref: MetaCyc:3.4.21.54-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004254 name: acylaminoacyl-peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: acylaminoacyl-peptide + H2O = acylamino acid + peptide." [EC:3.4.19.1] subset: gosubset_prok synonym: "acylamino-acid-releasing enzyme activity" EXACT [EC:3.4.19.1] synonym: "alpha-N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-acylpeptide hydrolase activity" EXACT [EC:3.4.19.1] synonym: "N-formylmethionine (fMet) aminopeptidase activity" EXACT [EC:3.4.19.1] xref: EC:3.4.19.1 xref: MetaCyc:ACYLAMINOACYL-PEPTIDASE-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004258 name: vacuolar carboxypeptidase Y namespace: molecular_function def: "OBSOLETE. Catalysis of the release of a C-terminal amino acid with a broad specificity." [EC:3.4.16.5] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0004185 consider: GO:0005773 [Term] id: GO:0004261 name: cathepsin G activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds. Specificity similar to chymotrypsin C." [EC:3.4.21.20] comment: This term was made obsolete because it represents a gene product. synonym: "chymotrypsin-like proteinase activity" EXACT [EC:3.4.21.20] synonym: "neutral proteinase activity" EXACT [EC:3.4.21.20] xref: EC:3.4.21.20 xref: MetaCyc:3.4.21.20-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004262 name: cerevisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity, and of BZ-Arg-OET > Ac-Tyr-OET. Does not hydrolyze peptide amides." [EC:3.4.21.48] comment: This term was made obsolete because it represents a gene product. synonym: "baker's yeast proteinase B" RELATED [EC:3.4.21.48] synonym: "brewer's yeast proteinase" NARROW [EC:3.4.21.48] synonym: "peptidase beta" RELATED [EC:3.4.21.48] synonym: "proteinase yscB activity" NARROW [EC:3.4.21.48] synonym: "yeast proteinase B activity" NARROW [EC:3.4.21.48] xref: EC:3.4.21.48 xref: MetaCyc:3.4.21.48-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004263 name: chymotrypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr-Xaa > Trp-Xaa > Phe-Xaa > Leu-Xaa." [EC:3.4.21.1, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alpha-chymar" RELATED [EC:3.4.21.1] synonym: "alpha-chymar ophth" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin A" RELATED [EC:3.4.21.1] synonym: "alpha-chymotrypsin activity" NARROW [EC:3.4.21.1] synonym: "avazyme" RELATED [EC:3.4.21.1] synonym: "chymar" RELATED [EC:3.4.21.1] synonym: "chymotest" RELATED [EC:3.4.21.1] synonym: "chymotrypsin A activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsin B activity" NARROW [EC:3.4.21.1] synonym: "chymotrypsins A and B" RELATED [EC:3.4.21.1] synonym: "enzeon" RELATED [EC:3.4.21.1] synonym: "quimar" RELATED [EC:3.4.21.1] synonym: "quimotrase activity" EXACT [EC:3.4.21.1] xref: EC:3.4.21.1 xref: MetaCyc:3.4.21.1-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004274 name: dipeptidyl-peptidase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal dipeptide, by the hydrolysis of the Xbb-Xcc bond in Xaa-Xbb-Xcc, preferentially when Xbb is Pro, provided Xcc is neither Pro nor hydroxyproline." [EC:3.4.14.5] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "amino acyl-prolyl dipeptidyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "dipeptidyl peptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "dipeptidyl-peptide hydrolase activity" EXACT [EC:3.4.14.5] synonym: "DPP IV activity" EXACT [EC:3.4.14.5] synonym: "DPP IV/CD26" RELATED [EC:3.4.14.5] synonym: "Gly-Pro naphthylamidase activity" EXACT [EC:3.4.14.5] synonym: "glycoprotein GP110" RELATED [EC:3.4.14.5] synonym: "glycylproline aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "glycylprolyl dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "leukocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "lymphocyte antigen CD26" RELATED [EC:3.4.14.5] synonym: "pep X" RELATED [EC:3.4.14.5] synonym: "post-proline dipeptidyl aminopeptidase IV activity" EXACT [EC:3.4.14.5] synonym: "postproline dipeptidyl aminopeptidase IV" RELATED [EC:3.4.14.5] synonym: "T cell triggering molecule Tp103" RELATED [EC:3.4.14.5] synonym: "X-PDAP" RELATED [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidyl-aminopeptidase activity" EXACT [EC:3.4.14.5] synonym: "Xaa-Pro-dipeptidylaminopeptidase activity" EXACT [EC:3.4.14.5] xref: EC:3.4.14.5 xref: MetaCyc:3.4.14.5-RXN is_obsolete: true replaced_by: GO:0008236 replaced_by: GO:0008239 [Term] id: GO:0004275 name: enteropeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the selective cleavage of Lys6-Ile7 bond in trypsinogen." [EC:3.4.21.9] comment: This term was made obsolete because it represents a gene product. synonym: "enterokinase activity" RELATED [EC:3.4.21.9] xref: EC:3.4.21.9 xref: MetaCyc:3.4.21.9-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004276 name: furin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of mature proteins from their proproteins by cleavage of the terminal bond of Arg-Xaa-Yaa-Arg-Z motifs where Xaa can be any amino acid and Yaa is Arg or Lys. Releases albumin, complement component C3 and von Willebrand factor from their respective precursors." [EC:3.4.21.75] comment: This term was made obsolete because it represents a gene product. synonym: "dibasic processing enzyme activity" EXACT [EC:3.4.21.75] synonym: "PACE" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid cleaving enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid converting enzyme" RELATED [EC:3.4.21.75] synonym: "paired basic amino acid residue cleaving enzyme activity" EXACT [EC:3.4.21.75] synonym: "prohormone convertase activity" NARROW [EC:3.4.21.75] synonym: "serine proteinase PACE" RELATED [EC:3.4.21.75] synonym: "SPC3" RELATED [EC:3.4.21.75] xref: EC:3.4.21.75 xref: MetaCyc:3.4.21.75-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004277 name: granzyme A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including fibronectin, type IV collagen and nucleolin. Preferential cleavage: Arg-Xaa > Lys-Xaa > Phe-Xaa in small molecule substrates." [EC:3.4.21.78] comment: This term was made obsolete because it represents a gene product. synonym: "CTLA3" RELATED [EC:3.4.21.78] synonym: "cytotoxic T lymphocyte serine protease" NARROW [EC:3.4.21.78] synonym: "cytotoxic T-lymphocyte proteinase 1 activity" NARROW [EC:3.4.21.78] synonym: "HuTPS" RELATED [EC:3.4.21.78] synonym: "T-cell associated protease 1" RELATED [EC:3.4.21.78] synonym: "T-cell derived serine proteinase" NARROW [EC:3.4.21.78] synonym: "TSP-1" RELATED [EC:3.4.21.78] xref: EC:3.4.21.78 xref: MetaCyc:3.4.21.78-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004278 name: granzyme B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Asp-Xaa > Asn-Xaa > Met-Xaa, Ser-Xaa." [EC:3.4.21.79] comment: This term was made obsolete because it represents a gene product. synonym: "CCP1 proteinase" NARROW [EC:3.4.21.79] synonym: "CCPII" RELATED [EC:3.4.21.79] synonym: "CTLA1" RELATED [EC:3.4.21.79] synonym: "cytotoxic cell proteinase-1" RELATED [EC:3.4.21.79] synonym: "cytotoxic t-lymphocyte proteinase 2 activity" NARROW [EC:3.4.21.79] synonym: "granzyme G" RELATED [EC:3.4.21.79] synonym: "granzyme H" RELATED [EC:3.4.21.79] xref: EC:3.4.21.79 xref: MetaCyc:3.4.21.79-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004281 name: pancreatic elastase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Leu-Xaa, Met-Xaa and Phe-Xaa. Hydrolyzes elastin." [EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. synonym: "pancreatic elastase 2" RELATED [EC:3.4.21.71] xref: EC:3.4.21.71 xref: MetaCyc:3.4.21.71-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004283 name: plasmin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Lys-Xaa > Arg-Xaa; higher selectivity than trypsin. Converts fibrin into soluble products." [EC:3.4.21.7] comment: This term was made obsolete because it represents a gene product. synonym: "actase activity" EXACT [EC:3.4.21.7] synonym: "fibrinase activity" EXACT [EC:3.4.21.7] synonym: "fibrinolysin activity" EXACT [EC:3.4.21.7] synonym: "serum tryptase activity" EXACT [EC:3.4.21.7] synonym: "thrombolysin" RELATED [EC:3.4.21.7] xref: EC:3.4.21.7 xref: MetaCyc:3.4.21.7-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004284 name: acrosin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa > Lys-Xaa." [EC:3.4.21.10] comment: This term was made obsolete because it represents a gene product. synonym: "acrosin amidase activity" EXACT [EC:3.4.21.10] synonym: "acrosomal protease activity" EXACT [EC:3.4.21.10] synonym: "acrosomal proteinase activity" EXACT [EC:3.4.21.10] synonym: "acrozonase activity" EXACT [EC:3.4.21.10] synonym: "alpha-acrosin" RELATED [EC:3.4.21.10] synonym: "beta-acrosin" RELATED [EC:3.4.21.10] synonym: "psi-acrosin" RELATED [EC:3.4.21.10] xref: EC:3.4.21.10 xref: MetaCyc:3.4.21.10-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004285 name: proprotein convertase 1 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones, neuropeptides and renin from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.93] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 1 activity" NARROW [EC:3.4.21.93] synonym: "neuroendocrine convertase 1 activity" NARROW [EC:3.4.21.93] synonym: "PC1 activity" NARROW [EC:3.4.21.93] synonym: "prohormone convertase 3" RELATED [EC:3.4.21.93] synonym: "prohormone convertase I activity" NARROW [EC:3.4.21.93] xref: EC:3.4.21.93 xref: MetaCyc:3.4.21.93-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004286 name: proprotein convertase 2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of protein hormones and neuropeptides from their precursors, generally by cleavage of -Lys-Arg-Xaa at the Arg-Xaa bond." [EC:3.4.21.94] comment: This term was made obsolete because it represents a gene product. synonym: "NEC 2 activity" NARROW [EC:3.4.21.94] synonym: "neuroendocrine convertase 2 activity" NARROW [EC:3.4.21.94] synonym: "PC2 activity" NARROW [EC:3.4.21.94] synonym: "prohormone convertase II activity" NARROW [EC:3.4.21.94] xref: EC:3.4.21.94 xref: MetaCyc:3.4.21.94-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004287 name: prolyl oligopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Pro-Xaa > Ala-Xaa in oligopeptides." [EC:3.4.21.26] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "endoprolylpeptidase activity" EXACT [EC:3.4.21.26] synonym: "post-proline cleaving enzyme activity" EXACT [EC:3.4.21.26] synonym: "post-proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "proline-specific endopeptidase activity" EXACT [EC:3.4.21.26] synonym: "prolyl endopeptidase activity" EXACT [EC:3.4.21.26] xref: EC:3.4.21.26 xref: MetaCyc:3.4.21.26-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004289 name: subtilase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004290 name: kexin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of the Arg-Xaa bond in Lys-Arg-Xaa and Arg-Arg-Xaa to process Yeast alpha-factor pheromone and killer toxin precursors." [EC:3.4.21.61] comment: This term was made obsolete because it represents a gene product. synonym: "andrenorphin-Gly-generating enzyme" RELATED [EC:3.4.21.61] synonym: "endoproteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "gene KEX2 dibasic proteinase" NARROW [EC:3.4.21.61] synonym: "Kex 2p proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 endopeptidase" NARROW [EC:3.4.21.61] synonym: "Kex2 endoprotease" NARROW [EC:3.4.21.61] synonym: "Kex2 endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2 protease" NARROW [EC:3.4.21.61] synonym: "Kex2 proteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like endoproteinase" NARROW [EC:3.4.21.61] synonym: "Kex2-like precursor protein processing endoprotease" NARROW [EC:3.4.21.61] synonym: "paired-basic endopeptidase activity" EXACT [EC:3.4.21.61] synonym: "prohormone-processing endoprotease activity" RELATED [EC:3.4.21.61] synonym: "prohormone-processing KEX2 proteinase" NARROW [EC:3.4.21.61] synonym: "prohormone-processing proteinase activity" EXACT [EC:3.4.21.61] synonym: "protease KEX2" RELATED [EC:3.4.21.61] synonym: "proteinase Kex2p" RELATED [EC:3.4.21.61] synonym: "proteinase yscF activity" NARROW [EC:3.4.21.61] synonym: "yeast cysteine proteinase F" RELATED [EC:3.4.21.61] synonym: "yeast KEX2 protease activity" NARROW [EC:3.4.21.61] xref: EC:3.4.21.61 xref: MetaCyc:3.4.21.61-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004291 name: subtilisin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, and a preference for a large uncharged residue in P1. Hydrolyzes peptide amides." [EC:3.4.21.62] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alcalase 0.6L" RELATED [EC:3.4.21.62] synonym: "alcalase 2.5L" RELATED [EC:3.4.21.62] synonym: "alcalase activity" EXACT [EC:3.4.21.62] synonym: "ALK-enzyme" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase A" RELATED [EC:3.4.21.62] synonym: "bacillopeptidase B" RELATED [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase activity" EXACT [EC:3.4.21.62] synonym: "bacillus subtilis alkaline proteinase bioprase activity" EXACT [EC:3.4.21.62] synonym: "bioprase AL 15" RELATED [EC:3.4.21.62] synonym: "bioprase APL 30" RELATED [EC:3.4.21.62] synonym: "colistinase activity" EXACT [EC:3.4.21.62] synonym: "esperase activity" EXACT [EC:3.4.21.62] synonym: "genenase I" RELATED [EC:3.4.21.62] synonym: "kazusase activity" EXACT [EC:3.4.21.62] synonym: "maxatase activity" EXACT [EC:3.4.21.62] synonym: "opticlean" RELATED [EC:3.4.21.62] synonym: "orientase 10B" RELATED [EC:3.4.21.62] synonym: "protease S" RELATED [EC:3.4.21.62] synonym: "protease VIII" RELATED [EC:3.4.21.62] synonym: "protease XXVII" RELATED [EC:3.4.21.62] synonym: "protin A 3L" RELATED [EC:3.4.21.62] synonym: "savinase 16.0L" RELATED [EC:3.4.21.62] synonym: "savinase 32.0 L EX" RELATED [EC:3.4.21.62] synonym: "savinase 4.0T" RELATED [EC:3.4.21.62] synonym: "savinase 8.0L" RELATED [EC:3.4.21.62] synonym: "savinase activity" EXACT [EC:3.4.21.62] synonym: "SP 266" RELATED [EC:3.4.21.62] synonym: "subtilisin BL" RELATED [EC:3.4.21.62] synonym: "subtilisin DY" RELATED [EC:3.4.21.62] synonym: "subtilisin E" RELATED [EC:3.4.21.62] synonym: "subtilisin GX" RELATED [EC:3.4.21.62] synonym: "subtilisin J" RELATED [EC:3.4.21.62] synonym: "subtilisin S41" RELATED [EC:3.4.21.62] synonym: "subtilisin sendai" RELATED [EC:3.4.21.62] synonym: "subtilopeptidase activity" EXACT [EC:3.4.21.62] synonym: "superase activity" EXACT [EC:3.4.21.62] synonym: "thermoase" BROAD [EC:3.4.21.62] synonym: "thermoase PC 10" RELATED [EC:3.4.21.62] xref: EC:3.4.21.62 xref: MetaCyc:3.4.21.62-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004293 name: tissue kallikrein activity namespace: molecular_function alt_id: GO:0004279 def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa bonds in small molecule substrates. Highly selective action to release kallidin (lysyl-bradykinin) from kininogen involves hydrolysis of Met-Xaa or Leu-Xaa. The rat enzyme is unusual in liberating bradykinin directly from autologous kininogens by cleavage at two Arg-Xaa bonds." [EC:3.4.21.35] comment: This term was made obsolete because it represents a gene product. synonym: "bradykininogenase" BROAD [EC:3.4.21.35] synonym: "callicrein" RELATED [EC:3.4.21.35] synonym: "depot-padutin" RELATED [EC:3.4.21.35] synonym: "dilminal D" RELATED [EC:3.4.21.35] synonym: "glandular kallikrein activity" RELATED [EC:3.4.21.35] synonym: "glumorin" RELATED [EC:3.4.21.35] synonym: "kallidinogenase" BROAD [EC:3.4.21.35] synonym: "kallikrein" RELATED [EC:3.4.21.35] synonym: "kidney kallikrein" RELATED [EC:3.4.21.35] synonym: "kininogenase" BROAD [EC:3.4.21.35] synonym: "kininogenin activity" RELATED [EC:3.4.21.35] synonym: "onokrein P" RELATED [EC:3.4.21.35] synonym: "padreatin" RELATED [EC:3.4.21.35] synonym: "padutin" RELATED [EC:3.4.21.35] synonym: "pancreatic kallikrein" RELATED [EC:3.4.21.35] synonym: "salivary kallikrein" RELATED [EC:3.4.21.35] synonym: "submandibular kallikrein" RELATED [EC:3.4.21.35] synonym: "submaxillary kallikrein" RELATED [EC:3.4.21.35] synonym: "urinary kallikrein" RELATED [EC:3.4.21.35] synonym: "urokallikrein" RELATED [EC:3.4.21.35] xref: EC:3.4.21.35 xref: MetaCyc:3.4.21.35-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004294 name: tripeptidyl-peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of an N-terminal tripeptide from a polypeptide at neutral pH." [EC:3.4.14.10] comment: This term was made obsolete because it represents a gene product. synonym: "TPP" RELATED [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl aminopeptidase II" RELATED [EC:3.4.14.10] synonym: "tripeptidyl peptidase activity" BROAD [EC:3.4.14.10] synonym: "tripeptidyl peptidase II" RELATED [EC:3.4.14.10] xref: EC:3.4.14.10 xref: MetaCyc:3.4.14.10-RXN is_obsolete: true replaced_by: GO:0008240 [Term] id: GO:0004295 name: trypsin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Arg-Xaa, Lys-Xaa." [EC:3.4.21.4] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "alpha-trypsin activity" NARROW [EC:3.4.21.4] synonym: "beta-trypsin activity" NARROW [EC:3.4.21.4] synonym: "cocoonase activity" EXACT [EC:3.4.21.4] synonym: "parenzyme" RELATED [EC:3.4.21.4] synonym: "parenzymol" RELATED [EC:3.4.21.4] synonym: "pseudotrypsin" RELATED [EC:3.4.21.4] synonym: "sperm receptor hydrolase activity" EXACT [EC:3.4.21.4] synonym: "tripcellim" RELATED [EC:3.4.21.4] synonym: "tryptar" RELATED [EC:3.4.21.4] synonym: "trypure" RELATED [EC:3.4.21.4] xref: EC:3.4.21.4 xref: MetaCyc:3.4.21.4-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0004298 name: threonine-type endopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of internal peptide bonds in a polypeptide chain by a mechanism in which the hydroxyl group of a threonine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#ENDOPEPTIDASE] subset: gosubset_prok synonym: "26S protease" NARROW [EC:3.4.25] synonym: "alkaline protease" RELATED [EC:3.4.25] synonym: "ingensin" RELATED [EC:3.4.25] synonym: "large multicatalytic protease" NARROW [EC:3.4.25] synonym: "lens neutral proteinase" NARROW [EC:3.4.25] synonym: "MCP" RELATED [EC:3.4.25] synonym: "multicatalytic endopeptidase complex" RELATED [EC:3.4.25] synonym: "multicatalytic proteinase" NARROW [EC:3.4.25] synonym: "multicatalytic proteinase (complex)" NARROW [EC:3.4.25] synonym: "prosome" RELATED [EC:3.4.25] synonym: "proteasome endopeptidase complex" NARROW [EC:3.4.25] synonym: "threonine endopeptidase activity" EXACT [] synonym: "tricorn protease" NARROW [EC:3.4.25] synonym: "tricorn proteinase" NARROW [EC:3.4.25] xref: EC:3.4.25 is_a: GO:0004175 ! endopeptidase activity is_a: GO:0070003 ! threonine-type peptidase activity [Term] id: GO:0004299 name: proteasome endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage at peptide bonds with very broad specificity." [EC:3.4.25.1] comment: This term was made obsolete because it mentions a component term in the text string. synonym: "multicatalytic endopeptidase" RELATED [] synonym: "proteasome" RELATED [] synonym: "proteasome endopeptidase complex" RELATED [] is_obsolete: true consider: GO:0004175 consider: GO:0008233 [Term] id: GO:0004300 name: enoyl-CoA hydratase activity namespace: molecular_function alt_id: GO:0016510 def: "Catalysis of the reaction: (3S)-3-hydroxyacyl-CoA = trans-2(or 3)-enoyl-CoA + H2O." [EC:4.2.1.17] subset: gosubset_prok synonym: "(3S)-3-hydroxyacyl-CoA hydro-lyase activity" EXACT [EC:4.2.1.17] synonym: "2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "2-octenoyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "acyl coenzyme A hydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacid dehydrase activity" EXACT [EC:4.2.1.17] synonym: "beta-hydroxyacyl-CoA dehydrase activity" EXACT [EC:4.2.1.17] synonym: "crotonyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "D-3-hydroxyacyl-CoA dehydratase" BROAD [EC:4.2.1.17] synonym: "ECH" RELATED [EC:4.2.1.17] synonym: "enol-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (D)" BROAD [EC:4.2.1.17] synonym: "enoyl coenzyme A hydrase (L)" EXACT [EC:4.2.1.17] synonym: "enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "enoyl hydrase activity" EXACT [EC:4.2.1.17] synonym: "hydratase, enoyl coenzyme A" EXACT [EC:4.2.1.17] synonym: "short chain enoyl coenzyme A hydratase activity" EXACT [EC:4.2.1.17] synonym: "short-chain enoyl-CoA hydratase activity" EXACT [] synonym: "trans-2-enoyl-CoA hydratase activity" EXACT [EC:4.2.1.17] synonym: "unsaturated acyl-CoA hydratase activity" EXACT [EC:4.2.1.17] xref: EC:4.2.1.17 xref: MetaCyc:ENOYL-COA-HYDRAT-RXN xref: Reactome:10287 "enoyl-CoA hydratase activity" xref: UM-BBD_enzymeID:e0014 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004301 name: epoxide hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: an epoxide + H2O = a glycol." [EC:3.3.2.10] subset: gosubset_prok synonym: "arene-oxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "aryl epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "cytosolic epoxide hydrolase activity" EXACT [EC:3.3.2.10] synonym: "epoxide hydrase activity" BROAD [EC:3.3.2.10] synonym: "epoxide hydratase activity" BROAD [EC:3.3.2.10] synonym: "sEH" RELATED [EC:3.3.2.10] synonym: "soluble epoxide hydrolase activity" NARROW [EC:3.3.2.10] synonym: "trans-stilbene oxide hydrolase activity" EXACT [EC:3.3.2.10] xref: EC:3.3.2.10 xref: MetaCyc:3.3.2.10-RXN xref: UM-BBD_enzymeID:e0397 is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004303 name: estradiol 17-beta-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: estradiol-17-beta + NADP+ = estrone + NADPH + H+." [EC:1.1.1.62] synonym: "17-beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17-beta-HSD activity" BROAD [EC:1.1.1.62] synonym: "17-beta-hydroxysteroid dehydrogenase activity" BROAD [EC:1.1.1.62] synonym: "17beta,20alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "17beta-HSD" RELATED [EC:1.1.1.62] synonym: "17beta-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "20alpha-hydroxysteroid dehydrogenase" BROAD [EC:1.1.1.62] synonym: "estradiol 17beta-dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol dehydrogenase activity" EXACT [EC:1.1.1.62] synonym: "estradiol-17beta:NAD(P)+ 17-oxidoreductase activity" EXACT [EC:1.1.1.62] synonym: "estrogen 17-oxidoreductase activity" EXACT [EC:1.1.1.62] xref: EC:1.1.1.62 xref: MetaCyc:ESTRADIOL-17-BETA-DEHYDROGENASE-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004304 name: estrone sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + estrone = adenosine 3',5'-bisphosphate + estrone 3-sulfate." [EC:2.8.2.4] synonym: "3'-phosphoadenylyl sulfate-estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylyl-sulfate:estrone 3-sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "3'-phosphoadenylylsulfate:oestrone sulfotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrogen sulfotransferase" BROAD [EC:2.8.2.4] synonym: "estrogen sulphotransferase activity" EXACT [EC:2.8.2.4] synonym: "estrone sulphotransferase activity" EXACT [] synonym: "oestrogen sulphotransferase activity" EXACT [EC:2.8.2.4] xref: EC:2.8.2.4 xref: MetaCyc:ESTRONE-SULFOTRANSFERASE-RXN xref: Reactome:10293 "estrone sulfotransferase activity" is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0004305 name: ethanolamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + ethanolamine = ADP + O-phosphoethanolamine." [EC:2.7.1.82] synonym: "ATP:ethanolamine O-phosphotransferase activity" EXACT [EC:2.7.1.82] synonym: "ethanolamine kinase (phosphorylating)" EXACT [EC:2.7.1.82] synonym: "ethanolamine phosphokinase activity" EXACT [EC:2.7.1.82] xref: EC:2.7.1.82 xref: MetaCyc:ETHANOLAMINE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004306 name: ethanolamine-phosphate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + ethanolamine phosphate = diphosphate + CDP-ethanolamine." [EC:2.7.7.14] synonym: "CTP-phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "CTP:ethanolamine-phosphate cytidylyltransferase activity" EXACT [] synonym: "CTP:phosphoethanolamine cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "ET" RELATED [EC:2.7.7.14] synonym: "ethanolamine phosphate cytidylyltransferase activity" EXACT [EC:2.7.7.14] synonym: "phosphoethanolamine cytidylyltransferase activity" EXACT [] synonym: "phosphorylethanolamine transferase activity" BROAD [EC:2.7.7.14] xref: EC:2.7.7.14 xref: MetaCyc:2.7.7.14-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004307 name: ethanolaminephosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-ethanolamine + 1,2-diacylglycerol = CMP + a phosphatidylethanolamine." [EC:2.7.8.1] synonym: "CDP-ethanolamine:1,2-diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "CDPethanolamine diglyceride phosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "diacylglycerol ethanolaminephosphotransferase activity" EXACT [EC:2.7.8.1] synonym: "EPT" RELATED [EC:2.7.8.1] synonym: "phosphorylethanolamine-glyceride transferase activity" EXACT [EC:2.7.8.1] xref: EC:2.7.8.1 xref: MetaCyc:ETHANOLAMINEPHOSPHOTRANSFERASE-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0004308 name: exo-alpha-sialidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)-glycosidic linkages of terminal sialic residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates." [EC:3.2.1.18] subset: gosubset_prok synonym: "acetylneuraminidase activity" EXACT [EC:3.2.1.18] synonym: "acetylneuraminyl hydrolase activity" EXACT [EC:3.2.1.18] synonym: "alpha-neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "N-acylneuraminate glycohydrolase activity" EXACT [EC:3.2.1.18] synonym: "neuraminidase activity" EXACT [EC:3.2.1.18] synonym: "sialidase activity" EXACT [EC:3.2.1.18] xref: EC:3.2.1.18 xref: MetaCyc:3.2.1.18-RXN xref: Reactome:10303 "exo-alpha-sialidase activity" is_a: GO:0016997 ! alpha-sialidase activity [Term] id: GO:0004309 name: exopolyphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: polyphosphate(n) + H2O = polyphosphate(n-1) + phosphate." [EC:3.6.1.11] subset: gosubset_prok synonym: "acid phosphoanhydride phosphohydrolase activity" EXACT [EC:3.6.1.11] synonym: "exopolypase activity" EXACT [EC:3.6.1.11] synonym: "Gra-Pase activity" EXACT [EC:3.6.1.11] synonym: "metaphosphatase activity" BROAD [EC:3.6.1.11] synonym: "polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.11] xref: EC:3.6.1.11 xref: MetaCyc:EXOPOLYPHOSPHATASE-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004310 name: farnesyl-diphosphate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 farnesyl diphosphate = diphosphate + presqualene diphosphate." [EC:2.5.1.21] comment: Note that the two reactions performed by EC:2.5.1.21 are represented in GO by 'farnesyl-diphosphate farnesyltransferase activity ; GO:0004310' and 'squalene synthase activity ; GO:0051996'. subset: gosubset_prok synonym: "farnesyl-diphosphate:farnesyl-diphosphate farnesyltransferase activity" EXACT [EC:2.5.1.21] synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.21] synonym: "presqualene synthase activity" EXACT [EC:2.5.1.21] synonym: "presqualene-diphosphate synthase activity" EXACT [EC:2.5.1.21] synonym: "squalene synthase activity" EXACT [EC:2.5.1.21] synonym: "squalene synthetase activity" EXACT [EC:2.5.1.21] xref: EC:2.5.1.21 xref: MetaCyc:2.5.1.21-RXN xref: Reactome:10334 "farnesyl-diphosphate farnesyltransferase activity" is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0004311 name: farnesyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: trans,trans-farnesyl diphosphate + isopentenyl diphosphate = diphosphate + geranylgeranyl diphosphate." [EC:2.5.1.29] subset: gosubset_prok synonym: "farnesyltransferase activity" BROAD [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-diphosphate synthase activity" EXACT [EC:2.5.1.29] synonym: "geranylgeranyl-PP synthetase activity" EXACT [EC:2.5.1.29] synonym: "trans,trans-farnesyl-diphosphate:isopentenyl-diphosphate farnesyltranstransferase activity" EXACT [EC:2.5.1.29] xref: EC:2.5.1.29 xref: MetaCyc:FARNESYLTRANSTRANSFERASE-RXN xref: Reactome:10335 "farnesyltranstransferase activity" is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004312 name: fatty acid synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADPH + 2n H+ = long-chain fatty acid + n+1 CoA + n CO2 + 2n NADP+." [EC:2.3.1.85] subset: gosubset_prok synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl-reducing and thioester-hydrolysing)" EXACT [EC:2.3.1.85] synonym: "fatty-acid synthase activity" EXACT [] xref: EC:2.3.1.85 xref: MetaCyc:FATTY-ACID-SYNTHASE-RXN is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0004313 name: [acyl-carrier-protein] S-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + [acyl-carrier protein] = CoA + acetyl-[acyl-carrier protein]." [EC:2.3.1.38] synonym: "[acyl-carrier protein] S-acetyltransferase activity" EXACT [] synonym: "ACAT activity" BROAD [EC:2.3.1.38] synonym: "acetyl coenzyme A-acyl-carrier-protein transacylase activity" EXACT [EC:2.3.1.38] synonym: "acetyl-CoA:acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "ACP S-acetyltransferase activity" EXACT [] synonym: "ACPacetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-protein S-acetyltransferase activity" EXACT [EC:2.3.1.38] synonym: "acyl-carrier-proteinacetyltransferase activity" EXACT [EC:2.3.1.38] xref: EC:2.3.1.38 xref: MetaCyc:ACP-S-ACETYLTRANSFER-RXN xref: Reactome:76142 "[acyl-carrier-protein] S-acetyltransferase activity" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016418 ! S-acetyltransferase activity [Term] id: GO:0004314 name: [acyl-carrier-protein] S-malonyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: malonyl-CoA + [acyl-carrier protein] = CoA + malonyl-[acyl-carrier protein]." [EC:2.3.1.39] subset: gosubset_prok synonym: "[acyl-carrier protein] S-malonyltransferase activity" EXACT [] synonym: "ACP S-malonyltransferase activity" EXACT [] synonym: "acyl carrier protein malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl carrier proteinmalonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "FabD" RELATED [EC:2.3.1.39] synonym: "malonyl coenzyme A-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl transacylase activity" BROAD [EC:2.3.1.39] synonym: "malonyl transferase activity" BROAD [EC:2.3.1.39] synonym: "malonyl-CoA-acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:ACP transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:AcpM transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl carrier protein transacylase activity" EXACT [EC:2.3.1.39] synonym: "malonyl-CoA:acyl-carrier-protein S-malonyltransferase activity" EXACT [EC:2.3.1.39] synonym: "MAT" RELATED [EC:2.3.1.39] synonym: "MCAT activity" EXACT [EC:2.3.1.39] xref: EC:2.3.1.39 xref: MetaCyc:MALONYL-COA-ACP-TRANSACYL-RXN xref: Reactome:10341 "[acyl-carrier-protein] S-malonyltransferase activity" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016419 ! S-malonyltransferase activity [Term] id: GO:0004315 name: 3-oxoacyl-[acyl-carrier-protein] synthase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + malonyl-[acyl-carrier protein] = 3-oxoacyl-[acyl-carrier protein] + CO2 + [acyl-carrier protein]." [EC:2.3.1.41] subset: gosubset_prok synonym: "3-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl-[acyl-carrier protein] synthase activity" EXACT [] synonym: "3-oxoacyl-ACP synthase activity" EXACT [] synonym: "3-oxoacyl-acyl-carrier-protein synthase activity" EXACT [EC:2.3.1.41] synonym: "3-oxoacyl:ACP synthase I" RELATED [EC:2.3.1.41] synonym: "acyl-acyl-carrier-protein:malonyl-acyl-carrier-protein C-acyltransferase (decarboxylating)" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl acyl carrier protein-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "acyl-malonyl(acyl-carrier-protein)-condensing enzyme activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-[acyl carrier protein] synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthase I activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-ACP synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl carrier protein synthetase activity" EXACT [EC:2.3.1.41] synonym: "beta-ketoacyl-acyl-carrier-protein synthase I" RELATED [EC:2.3.1.41] synonym: "beta-ketoacylsynthase activity" EXACT [EC:2.3.1.41] synonym: "condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "FabB" RELATED [EC:2.3.1.41] synonym: "FabF1" RELATED [EC:2.3.1.41] synonym: "fatty acid condensing enzyme activity" BROAD [EC:2.3.1.41] synonym: "KAS I activity" NARROW [EC:2.3.1.41] synonym: "KASI" RELATED [EC:2.3.1.41] synonym: "ketoacyl-ACP synthase activity" EXACT [] xref: EC:2.3.1.41 xref: MetaCyc:3-OXOACYL-ACP-SYNTH-RXN xref: Reactome:76136 "3-oxoacyl-[acyl-carrier-protein] synthase activity" is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0004316 name: 3-oxoacyl-[acyl-carrier-protein] reductase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxyacyl-[acyl-carrier protein] + NADP+ = 3-oxoacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.1.1.100] subset: gosubset_prok synonym: "(3R)-3-hydroxyacyl-acyl-carrier-protein:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.100] synonym: "3-ketoacyl acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-[acyl-carrier protein] reductase activity" EXACT [] synonym: "3-oxoacyl-ACP reductase activity" EXACT [] synonym: "3-oxoacyl-ACPreductase activity" EXACT [EC:1.1.1.100] synonym: "3-oxoacyl-acyl-carrier-protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl acyl carrier protein (ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl thioester reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-ACP reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl carrier protein reductase activity" EXACT [EC:1.1.1.100] synonym: "beta-ketoacyl-acyl-carrier protein(ACP) reductase activity" EXACT [EC:1.1.1.100] synonym: "NADPH-specific 3-oxoacyl-acylcarrier proteinreductase activity" EXACT [EC:1.1.1.100] xref: EC:1.1.1.100 xref: MetaCyc:3-OXOACYL-ACP-REDUCT-RXN xref: Reactome:76148 "3-oxoacyl-[acyl-carrier-protein] reductase activity" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004317 name: 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxypalmitoyl-[acyl-carrier protein] = 2-hexadecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase (hexadec-2-enoyl-acyl-carrier protein-forming)" EXACT [EC:4.2.1.61] synonym: "(3R)-3-hydroxypalmitoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.61] synonym: "3-hydroxypalmitoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl thioester dehydratase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmitoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.61] synonym: "beta-hydroxypalmityl-ACP dehydrase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.61] synonym: "D-3-hydroxypalmitoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.61] xref: EC:4.2.1.61 xref: MetaCyc:4.2.1.61-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0004318 name: enoyl-[acyl-carrier-protein] reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NAD+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADH + H+." [EC:1.3.1.9] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NAD+ oxidoreductase" EXACT [EC:1.3.1.9] synonym: "enoyl-[acyl-carrier protein] reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-ACP reductase (NADH) activity" EXACT [EC:1.3.1.9] synonym: "enoyl-acyl-carrier-protein reductase (NADH)" EXACT [EC:1.3.1.9] synonym: "NADH-enoyl acyl carrier protein reductase activity" EXACT [EC:1.3.1.9] synonym: "NADH-specific enoyl-ACP reductase activity" EXACT [EC:1.3.1.9] xref: EC:1.3.1.9 xref: MetaCyc:ENOYL-ACP-REDUCT-NADH-RXN is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity [Term] id: GO:0004319 name: enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + NADP+ = trans-2,3-dehydroacyl-[acyl-carrier protein] + NADPH + H+." [EC:1.3.1.10] subset: gosubset_prok synonym: "acyl-acyl-carrier-protein:NADP+ oxidoreductase (B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl acyl-carrier-protein reductase activity" EXACT [EC:1.3.1.10] synonym: "enoyl-[acyl-carrier protein] reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-ACP reductase (NADPH, B-specific) activity" EXACT [] synonym: "enoyl-acyl-carrier-protein reductase (NADPH, B-specific)" EXACT [EC:1.3.1.10] synonym: "enoyl-acyl-carrier-protein reductase (NADPH2, B-specific)" EXACT [EC:1.3.1.10] synonym: "NADPH 2-enoyl Co A reductase activity" EXACT [EC:1.3.1.10] synonym: "reductase, enoyl-acyl carrier protein (reduced nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.3.1.10] xref: EC:1.3.1.10 xref: MetaCyc:ENOYL-ACP-REDUCT-NADPH-RXN xref: Reactome:76151 "enoyl-[acyl-carrier-protein] reductase (NADPH, B-specific) activity" is_a: GO:0004312 ! fatty acid synthase activity is_a: GO:0016631 ! enoyl-[acyl-carrier-protein] reductase activity [Term] id: GO:0004320 name: oleoyl-[acyl-carrier-protein] hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: oleoyl-[acyl-carrier protein] + H2O = [acyl-carrier protein] + oleate." [EC:3.1.2.14] subset: gosubset_prok synonym: "oleoyl-[acyl-carrier protein] hydrolase activity" EXACT [] synonym: "oleoyl-ACP hydrolase activity" EXACT [] synonym: "oleoyl-ACP thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl carrier protein thioesterase activity" EXACT [EC:3.1.2.14] synonym: "oleoyl-acyl-carrier-protein hydrolase" BROAD [EC:3.1.2.14] xref: EC:3.1.2.14 xref: MetaCyc:3.1.2.14-RXN xref: MetaCyc:PWY-5142 xref: Reactome:76154 "oleoyl-[acyl-carrier-protein] hydrolase activity" is_a: GO:0016297 ! acyl-[acyl-carrier-protein] hydrolase activity [Term] id: GO:0004321 name: fatty-acyl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + n malonyl-CoA + 2n NADH + 2n NADPH + 4n H+ = a long-chain acyl-CoA + n CoA + n CO2 + 2n NAD+ + 2n NADP+." [EC:2.3.1.86] synonym: "acyl-CoA:malonyl-CoA C-acyltransferase (decarboxylating, oxoacyl- and enoyl- reducing)" EXACT [EC:2.3.1.86] synonym: "yeast fatty acid synthase activity" NARROW [EC:2.3.1.86] xref: EC:2.3.1.86 xref: MetaCyc:FATTY-ACYL-COA-SYNTHASE-RXN is_a: GO:0016408 ! C-acyltransferase activity [Term] id: GO:0004322 name: ferroxidase activity namespace: molecular_function def: "Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] subset: gosubset_prok synonym: "caeruloplasmin" RELATED [EC:1.16.3.1] synonym: "ceruloplasmin activity" NARROW [EC:1.16.3.1] synonym: "Fe(II):oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferro:O2 oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "ferroxidase I" RELATED [EC:1.16.3.1] synonym: "ferroxidase, iron II:oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "iron(II): oxygen oxidoreductase activity" EXACT [EC:1.16.3.1] synonym: "multicopper ferroxidase iron transport mediator activity" NARROW [] xref: EC:1.16.3.1 xref: MetaCyc:RXN0-1483 is_a: GO:0016724 ! oxidoreductase activity, oxidizing metal ions, oxygen as acceptor [Term] id: GO:0004323 name: multicopper ferroxidase iron transport mediator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: 4 Fe2+ + 4 H+ + O2 = 4 Fe3+ + 2 H2O." [EC:1.16.3.1] comment: This term was made obsolete because it represents a multifunctional gene product. is_obsolete: true consider: GO:0004322 consider: GO:0005381 [Term] id: GO:0004324 name: ferredoxin-NADP+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NADP+ = oxidized ferredoxin + NADPH + H+." [EC:1.18.1.2, GOC:kd] comment: Note that this term specifically refers to the reaction proceeding in the direction shown; it should therefore be used to annotate gene products that catalyze the oxidation of reduced ferredoxin or adrenodoxin; also consider annotating to the molecular function term 'NADPH-adrenodoxin reductase activity ; GO:0015039'. subset: gosubset_prok synonym: "ferredoxin-NADP oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-NADP reductase activity" EXACT [] synonym: "ferredoxin-NADP-oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide adenine dinucleotide phosphate reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-nicotinamide-adenine dinucleotide phosphate (oxidized) reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin-TPN reductase activity" EXACT [EC:1.18.1.2] synonym: "ferredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADP:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "NADPH:ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.2] synonym: "reduced nicotinamide adenine dinucleotide phosphate-adrenodoxin reductase activity" EXACT [EC:1.18.1.2] synonym: "TPNH-ferredoxin reductase activity" EXACT [EC:1.18.1.2] xref: EC:1.18.1.2 xref: MetaCyc:1.18.1.2-RXN is_a: GO:0008937 ! ferredoxin reductase activity [Term] id: GO:0004325 name: ferrochelatase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrin + Fe2+ = protoheme + 2 H+." [EC:4.99.1.1] subset: gosubset_prok synonym: "ferro-protoporphyrin chelatase activity" EXACT [EC:4.99.1.1] synonym: "heme synthase activity" EXACT [EC:4.99.1.1] synonym: "heme synthetase activity" EXACT [EC:4.99.1.1] synonym: "iron chelatase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase (protoporphyrin-forming)" EXACT [EC:4.99.1.1] synonym: "protoheme ferro-lyase activity" EXACT [EC:4.99.1.1] synonym: "protoheme ferrolyase activity" EXACT [EC:4.99.1.1] xref: EC:4.99.1.1 xref: MetaCyc:PROTOHEMEFERROCHELAT-RXN xref: Reactome:10394 "ferrochelatase activity" is_a: GO:0016829 ! lyase activity [Term] id: GO:0004326 name: tetrahydrofolylpolyglutamate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tetrahydrofolyl-(Glu)(n) + L-glutamate = ADP + phosphate + tetrahydrofolyl-(Glu)(n+1)." [EC:6.3.2.17] subset: gosubset_prok synonym: "folate polyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly(gamma-glutamate) synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthase activity" EXACT [EC:6.3.2.17] synonym: "folylpoly-gamma-glutamate synthetase-dihydrofolate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamate synthase activity" EXACT [] synonym: "folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "folylpolyglutamyl synthetase activity" EXACT [EC:6.3.2.17] synonym: "formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "FPGS activity" EXACT [EC:6.3.2.17] synonym: "N(10)-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "N10-formyltetrahydropteroyldiglutamate synthetase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate synthase activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolate:L-glutamate gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.17] synonym: "tetrahydrofolyl-[gamma-Glu]n:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] synonym: "tetrahydropteroyl-[gamma-polyglutamate]:L-glutamate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.17] xref: EC:6.3.2.17 xref: MetaCyc:FOLYLPOLYGLUTAMATESYNTH-RXN xref: Reactome:10396 "tetrahydrofolylpolyglutamate synthase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004327 name: formaldehyde dehydrogenase (glutathione) activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: formaldehyde + glutathione + NAD+ = S-formylglutathione + NADH + H+." [EC:1.2.1.1] comment: This term was made obsolete because it was derived from an EC entry (1.2.1.1) that has since been split into two entries. subset: gosubset_prok xref: UM-BBD_enzymeID:e0028 is_obsolete: true consider: GO:0051903 consider: GO:0051907 [Term] id: GO:0004328 name: formamidase activity namespace: molecular_function def: "Catalysis of the reaction: formamide + H2O = formate + NH3." [EC:3.5.1.49] subset: gosubset_prok synonym: "formamide amidohydrolase activity" EXACT [EC:3.5.1.49] xref: EC:3.5.1.49 xref: MetaCyc:FORMAMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004329 name: formate-tetrahydrofolate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + formate + tetrahydrofolate = ADP + phosphate + 10-formyltetrahydrofolate." [EC:6.3.4.3] subset: gosubset_prok synonym: "10-formyl-THF synthetase activity" EXACT [GOC:vw] synonym: "10-formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "formate:tetrahydrofolate ligase (ADP-forming)" EXACT [EC:6.3.4.3] synonym: "formyltetrahydrofolate synthetase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolate formylase activity" EXACT [EC:6.3.4.3] synonym: "tetrahydrofolic formylase activity" EXACT [EC:6.3.4.3] xref: EC:6.3.4.3 xref: MetaCyc:FORMATETHFLIG-RXN xref: Reactome:10407 "formate-tetrahydrofolate ligase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004331 name: fructose-2,6-bisphosphate 2-phosphatase activity namespace: molecular_function alt_id: GO:0004330 def: "Catalysis of the reaction: D-fructose 2,6-bisphosphate + H2O = D-fructose 6-phosphate + phosphate." [EC:3.1.3.46] subset: gosubset_prok synonym: "beta-D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "D-fructose-2,6-bisphosphate 2-phosphohydrolase activity" EXACT [EC:3.1.3.46] synonym: "fructose-2,6-bisphosphatase activity" EXACT [EC:3.1.3.46] xref: EC:3.1.3.46 xref: MetaCyc:3.1.3.46-RXN xref: Reactome:10434 "fructose-2,6-bisphosphate 2-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004332 name: fructose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-fructose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.13] subset: gosubset_prok synonym: "1,6-diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "aldolase activity" BROAD [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.13] synonym: "D-fructose-1,6-bisphosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "diphosphofructose aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-monophosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose diphosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "fructose-1,6-bisphosphate triosephosphate-lyase activity" EXACT [EC:4.1.2.13] synonym: "ketose 1-phosphate aldolase activity" EXACT [EC:4.1.2.13] synonym: "phosphofructoaldolase activity" EXACT [EC:4.1.2.13] synonym: "SMALDO" RELATED [EC:4.1.2.13] synonym: "zymohexase activity" EXACT [EC:4.1.2.13] xref: EC:4.1.2.13 xref: MetaCyc:F16ALDOLASE-RXN xref: Reactome:10435 "fructose-bisphosphate aldolase activity" is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004333 name: fumarate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate = fumarate + H2O." [EC:4.2.1.2] subset: gosubset_prok synonym: "(S)-malate hydro-lyase (fumarate-forming)" EXACT [EC:4.2.1.2] synonym: "(S)-malate hydro-lyase activity" EXACT [EC:4.2.1.2] synonym: "fumarase activity" EXACT [EC:4.2.1.2] synonym: "L-malate hydro-lyase activity" EXACT [EC:4.2.1.2] xref: EC:4.2.1.2 xref: MetaCyc:FUMHYDR-RXN xref: Reactome:10436 "fumarate hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004334 name: fumarylacetoacetase activity namespace: molecular_function def: "Catalysis of the reaction: 4-fumarylacetoacetate + H2O = acetoacetate + fumarate." [EC:3.7.1.2] subset: gosubset_prok synonym: "4-fumarylacetoacetate fumarylhydrolase activity" EXACT [EC:3.7.1.2] synonym: "beta-diketonase activity" EXACT [EC:3.7.1.2] synonym: "fumarylacetoacetate hydrolase activity" EXACT [EC:3.7.1.2] xref: EC:3.7.1.2 xref: MetaCyc:FUMARYLACETOACETASE-RXN xref: Reactome:10438 "fumarylacetoacetase activity" xref: UM-BBD_enzymeID:e0083 is_a: GO:0016823 ! hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances [Term] id: GO:0004335 name: galactokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-galactose = ADP + D-galactose 1-phosphate." [EC:2.7.1.6] subset: gosubset_prok synonym: "ATP:D-galactose 1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "ATP:D-galactose-1-phosphotransferase activity" EXACT [EC:2.7.1.6] synonym: "galactokinase (phosphorylating)" EXACT [EC:2.7.1.6] xref: EC:2.7.1.6 xref: MetaCyc:GALACTOKIN-RXN xref: Reactome:10440 "galactokinase activity" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004336 name: galactosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactosyl-N-acylsphingosine + H2O = D-galactose + N-acylsphingosine." [EC:3.2.1.46] synonym: "beta-galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "beta-galactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "ceramide galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "cerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "D-galactosyl-N-acylsphingosine galactohydrolase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside-beta-D-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactocerebroside.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramidase I" RELATED [EC:3.2.1.46] synonym: "galactosylceramide beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylceramide.beta-galactosidase activity" EXACT [EC:3.2.1.46] synonym: "galactosylcerebrosidase activity" EXACT [EC:3.2.1.46] synonym: "galcerase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase activity" EXACT [EC:3.2.1.46] synonym: "lactosylceramidase I" RELATED [EC:3.2.1.46] xref: EC:3.2.1.46 xref: MetaCyc:GALACTOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0004337 name: geranyltranstransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranyl diphosphate + isopentenyl diphosphate = diphosphate + trans,trans-farnesyl diphosphate." [EC:2.5.1.10] comment: Note that this is the second step in the formation of farnesyl diphosphate. The first step is 'dimethylallyltransferase activity ; GO:0004161'. Consider also annotating to the biological process term 'farnesyl diphosphate biosynthetic process ; GO:0045337'. subset: gosubset_prok synonym: "farnesyl diphosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "farnesyl pyrophosphate synthetase activity" EXACT [] synonym: "farnesyl-diphosphate synthase activity" EXACT [] synonym: "farnesylpyrophosphate synthetase activity" EXACT [EC:2.5.1.10] synonym: "FPP synthetase activity" EXACT [EC:2.5.1.10] synonym: "geranyl transferase I" RELATED [EC:2.5.1.10] synonym: "geranyl-diphosphate:isopentenyl-diphosphate geranyltranstransferase activity" EXACT [EC:2.5.1.10] synonym: "geranyltransferase activity" EXACT [EC:2.5.1.10] xref: EC:2.5.1.10 xref: MetaCyc:FPPSYN-RXN is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0004338 name: glucan 1,3-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the successive hydrolysis of beta-D-glucose units from the non-reducing ends of 1,3-beta-D-glucans, releasing alpha-glucose." [EC:3.2.1.58] synonym: "1,3-beta-glucan glucohydrolase activity" EXACT [EC:3.2.1.58] synonym: "beta-1,3-glucan exo-hydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo (1->3)-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-1,3-beta-glucosidase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-(1->3)-glucanohydrolase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-D-glucanase activity" EXACT [EC:3.2.1.58] synonym: "exo-beta-1,3-glucanase activity" EXACT [EC:3.2.1.58] xref: EC:3.2.1.58 xref: MetaCyc:3.2.1.58-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0004339 name: glucan 1,4-alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal 1,4-linked alpha-D-glucose residues successively from non-reducing ends of the chains with release of beta-D-glucose." [EC:3.2.1.3] comment: Note that this term is not a child of 'alpha-glucosidase activity ; GO:0004558', because in the reaction represented by GO:0004339 results in the release of beta-D-glucose, whereas in GO:0004558 alpha-D-glucose is released. subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "amyloglucosidase activity" EXACT [EC:3.2.1.3] synonym: "exo-1,4-alpha-glucosidase activity" EXACT [EC:3.2.1.3] synonym: "gamma-1,4-glucan glucohydrolase activity" EXACT [EC:3.2.1.3] synonym: "gamma-amylase activity" EXACT [EC:3.2.1.3] synonym: "glucoamylase activity" EXACT [] synonym: "glucose amylase activity" EXACT [EC:3.2.1.3] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.3] xref: EC:3.2.1.3 xref: MetaCyc:3.2.1.3-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004340 name: glucokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-glucose = ADP + D-glucose 6-phosphate." [EC:2.7.1.2] subset: gosubset_prok synonym: "ATP:D-glucose 6-phosphotransferase activity" EXACT [EC:2.7.1.2] synonym: "glucokinase (phosphorylating)" EXACT [EC:2.7.1.2] synonym: "glucose kinase activity" EXACT [EC:2.7.1.2] xref: EC:2.7.1.2 xref: MetaCyc:GLUCOKIN-RXN xref: Reactome:10457 "glucokinase activity" is_a: GO:0004396 ! hexokinase activity relationship: part_of GO:0051156 ! glucose 6-phosphate metabolic process [Term] id: GO:0004341 name: gluconolactonase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate." [EC:3.1.1.17] subset: gosubset_prok synonym: "aldonolactonase activity" EXACT [EC:3.1.1.17] synonym: "D-glucono-1,5-lactone lactonohydrolase activity" EXACT [EC:3.1.1.17] synonym: "glucono-delta-lactonase activity" EXACT [EC:3.1.1.17] synonym: "gulonolactonase activity" EXACT [EC:3.1.1.17] synonym: "lactonase activity" BROAD [EC:3.1.1.17] xref: EC:3.1.1.17 xref: MetaCyc:GLUCONOLACT-RXN is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004342 name: glucosamine-6-phosphate deaminase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 6-phosphate + H2O = D-fructose 6-phosphate + NH3." [EC:3.5.99.6] comment: Note that this function was formerly EC:5.3.1.10. subset: gosubset_prok synonym: "2-amino-2-deoxy-D-glucose-6-phosphate aminohydrolase (ketol isomerizing)" EXACT [EC:3.5.99.6] synonym: "aminodeoxyglucosephosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "GlcN6P deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine phosphate deaminase activity" EXACT [EC:3.5.99.6] synonym: "glucosamine-6-phosphate isomerase activity" EXACT [EC:3.5.99.6] synonym: "glucosaminephosphate isomerase" BROAD [EC:3.5.99.6] synonym: "phosphoglucosamine isomerase activity" EXACT [EC:3.5.99.6] synonym: "phosphoglucosaminisomerase activity" EXACT [EC:3.5.99.6] xref: EC:3.5.99.6 xref: MetaCyc:GLUCOSAMINE-6-P-DEAMIN-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses is_a: GO:0019239 ! deaminase activity [Term] id: GO:0004343 name: glucosamine 6-phosphate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + D-glucosamine 6-phosphate = CoA + N-acetyl-D-glucosamine 6-phosphate." [EC:2.3.1.4] subset: gosubset_prok synonym: "acetyl-CoA:D-glucosamine-6-phosphate N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "aminodeoxyglucosephosphate acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "D-glucosamine-6-P N-acetyltransferase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine 6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-6-phosphate acetylase activity" EXACT [EC:2.3.1.4] synonym: "glucosamine-phosphate N-acetyltransferase activity" EXACT [] synonym: "N-acetylglucosamine-6-phosphate synthase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine N-acetylase activity" EXACT [EC:2.3.1.4] synonym: "phosphoglucosamine transacetylase activity" EXACT [EC:2.3.1.4] xref: EC:2.3.1.4 xref: MetaCyc:GLUCOSAMINEPNACETYLTRANS-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004344 name: glucose dehydrogenase activity namespace: molecular_function alt_id: GO:0008708 def: "Catalysis of the reaction: D-glucose + acceptor = D-glucono-1,5-lactone + reduced acceptor." [EC:1.1.99.10] synonym: "D-glucose:(acceptor) 1-oxidoreductase" EXACT [EC:1.1.99.10] synonym: "D-glucose:acceptor 1-oxidoreductase" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (acceptor) activity" EXACT [] synonym: "glucose dehydrogenase (Aspergillus) activity" NARROW [EC:1.1.99.10] synonym: "glucose dehydrogenase (decarboxylating)" EXACT [EC:1.1.99.10] xref: EC:1.1.-.- xref: EC:1.1.99.10 xref: MetaCyc:GLUCOSE-DEHYDROGENASE-ACCEPTOR-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004345 name: glucose-6-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + NADP+ = D-glucono-1,5-lactone 6-phosphate + NADPH + H+." [EC:1.1.1.49] subset: gosubset_prok synonym: "6-phosphoglucose dehydrogenas" RELATED [] synonym: "6-phosphoglucose dehydrogenase activity" EXACT [] synonym: "D-glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "D-glucose-6-phosphate:NADP+ 1-oxidoreductase activity" EXACT [EC:1.1.1.49] synonym: "Entner-doudoroff enzyme" RELATED [EC:1.1.1.49] synonym: "G6PD activity" EXACT [EC:1.1.1.49] synonym: "G6PDH" EXACT [] synonym: "GDH" RELATED [] synonym: "glucose 6-phosphate dehydrogenase (NADP) activity" EXACT [] synonym: "glucose-6-phosphate 1-dehydrogenase activity" EXACT [] synonym: "NADP-dependent glucose 6-phosphate dehydrogenase activity" EXACT [] synonym: "NADP-glucose-6-phosphate dehydrogenase activity" EXACT [] synonym: "Zwischenferment" RELATED [] synonym: "zwischenferment" RELATED [EC:1.1.1.49] xref: EC:1.1.1.49 xref: MetaCyc:GLU6PDEHYDROG-RXN xref: Reactome:10468 "glucose-6-phosphate dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004346 name: glucose-6-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.9] synonym: "glucose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.9] xref: EC:3.1.3.9 xref: MetaCyc:GLUCOSE-6-PHOSPHATASE-RXN xref: Reactome:10470 "glucose-6-phosphatase activity" is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004347 name: glucose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.9] subset: gosubset_prok synonym: "D-glucose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.9] synonym: "D-glucose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.9] synonym: "glucose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexose monophosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "hexose phosphate isomerase activity" EXACT [EC:5.3.1.9] synonym: "hexosephosphate isomerase activity" BROAD [EC:5.3.1.9] synonym: "oxoisomerase activity" RELATED [EC:5.3.1.9] synonym: "phosphoglucoisomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphoglucose isomerase activity" EXACT [EC:5.3.1.9] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.9] synonym: "phosphohexose isomerase activity" BROAD [EC:5.3.1.9] synonym: "phosphosaccharomutase activity" BROAD [EC:5.3.1.9] xref: EC:5.3.1.9 xref: MetaCyc:PGLUCISOM-RXN xref: Reactome:10472 "glucose-6-phosphate isomerase activity" is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004348 name: glucosylceramidase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosyl-N-acylsphingosine + H2O = D-glucose + N-acylsphingosine." [EC:3.2.1.45] subset: gosubset_prok synonym: "acid beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-D-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "beta-glucosylceramidase activity" EXACT [EC:3.2.1.45] synonym: "ceramide glucosidase activity" EXACT [EC:3.2.1.45] synonym: "D-glucosyl-N-acylsphingosine glucohydrolase activity" EXACT [EC:3.2.1.45] synonym: "GlcCer-beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucocerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosphingosine glucosylhydrolase activity" EXACT [EC:3.2.1.45] synonym: "glucosylcerebrosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-D-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "glucosylsphingosine beta-glucosidase activity" EXACT [EC:3.2.1.45] synonym: "psychosine hydrolase activity" EXACT [EC:3.2.1.45] xref: EC:3.2.1.45 xref: MetaCyc:GLUCOSYLCERAMIDASE-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds is_a: GO:0017040 ! ceramidase activity [Term] id: GO:0004349 name: glutamate 5-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate = ADP + L-glutamate 5-phosphate." [EC:2.7.2.11] subset: gosubset_prok synonym: "ATP-L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:gamma-L-glutamate phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "ATP:L-glutamate 5-phosphotransferase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamate kinase activity" EXACT [EC:2.7.2.11] synonym: "gamma-glutamyl kinase activity" EXACT [EC:2.7.2.11] synonym: "glutamate kinase activity" EXACT [EC:2.7.2.11] xref: EC:2.7.2.11 xref: MetaCyc:GLUTKIN-RXN is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004350 name: glutamate-5-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0001513 def: "Catalysis of the reaction: L-glutamate 5-semialdehyde + phosphate + NADP+ = L-gamma-glutamyl 5-phosphate + NADPH + H+." [EC:1.2.1.41] subset: gosubset_prok synonym: "beta-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamyl phosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "gamma-glutamylphosphate reductase activity" EXACT [EC:1.2.1.41] synonym: "glutamate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamate-phosphate reductase activity" EXACT [] synonym: "glutamyl-gamma-semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.41] synonym: "glutamylphosphate reductase activity" EXACT [] synonym: "L-glutamate-5-semialdehyde:NADP+ 5-oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.41] xref: EC:1.2.1.41 xref: MetaCyc:GLUTSEMIALDEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004351 name: glutamate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2." [EC:4.1.1.15] subset: gosubset_prok synonym: "aspartic alpha-decarboxylase" BROAD [EC:4.1.1.15] synonym: "cysteic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "gamma-glutamate decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-aspartate-alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase (4-aminobutanoate-forming)" EXACT [EC:4.1.1.15] synonym: "L-glutamate 1-carboxy-lyase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamate alpha-decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic acid decarboxylase activity" EXACT [EC:4.1.1.15] synonym: "L-glutamic decarboxylase activity" EXACT [EC:4.1.1.15] xref: EC:4.1.1.15 xref: MetaCyc:GLUTDECARBOX-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004352 name: glutamate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD+ = 2-oxoglutarate + NH3 + NADH + H+." [EC:1.4.1.2] subset: gosubset_prok synonym: "glutamate dehydrogenase (NAD)" EXACT [EC:1.4.1.2] synonym: "glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.2] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.2] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.2] synonym: "L-glutamate:NAD+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-dependent glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-linked glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD-specific glutamic dehydrogenase activity" EXACT [EC:1.4.1.2] synonym: "NAD:glutamate oxidoreductase activity" EXACT [EC:1.4.1.2] synonym: "NADH-linked glutamate dehydrogenase activity" EXACT [EC:1.4.1.2] xref: EC:1.4.1.2 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-RXN is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004353 name: glutamate dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NAD(P)+ = 2-oxoglutarate + NH3 + NAD(P)H + H+." [EC:1.4.1.3] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" RELATED [] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.3] synonym: "L-glutamate:NAD(P)+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.3] xref: EC:1.4.1.3 xref: MetaCyc:GLUTAMATE-DEHYDROGENASE-NADP+-RXN xref: MetaCyc:GLUTAMATE-SYN2-PWY xref: Reactome:10485 "glutamate dehydrogenase [NAD(P)+] activity" is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004354 name: glutamate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate + H2O + NADP+ = 2-oxoglutarate + NH3 + NADPH + H+." [EC:1.4.1.4] subset: gosubset_prok synonym: "dehydrogenase, glutamate (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.4.1.4] synonym: "glutamic acid dehydrogenase" BROAD [EC:1.4.1.4] synonym: "glutamic dehydrogenase activity" BROAD [EC:1.4.1.4] synonym: "L-glutamate dehydrogenase" BROAD [EC:1.4.1.4] synonym: "L-glutamate:NADP+ oxidoreductase (deaminating)" EXACT [EC:1.4.1.4] synonym: "L-glutamic acid dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)-glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] synonym: "NAD(P)H-dependent glutamate dehydrogenase activity" EXACT [EC:1.4.1.4] xref: EC:1.4.1.4 xref: MetaCyc:GLUTDEHYD-RXN xref: MetaCyc:GLUTSYNIII-PWY is_a: GO:0016639 ! oxidoreductase activity, acting on the CH-NH2 group of donors, NAD or NADP as acceptor [Term] id: GO:0004355 name: glutamate synthase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-glutamate + NADP+ = L-glutamine + 2-oxoglutarate + NADPH + H+." [EC:1.4.1.13] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "glutamate (reduced nicotinamide adenine dinucleotide phosphate) synthase activity" EXACT [EC:1.4.1.13] synonym: "glutamate synthetase (NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine amide-2-oxoglutarate aminotransferase (oxidoreductase, NADP) activity" EXACT [EC:1.4.1.13] synonym: "glutamine-ketoglutaric aminotransferase activity" EXACT [EC:1.4.1.13] synonym: "GOGAT activity" EXACT [EC:1.4.1.13] synonym: "L-glutamate synthase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate synthetase activity" BROAD [EC:1.4.1.13] synonym: "L-glutamate:NADP+ oxidoreductase (transaminating)" EXACT [EC:1.4.1.13] synonym: "L-glutamine:2-oxoglutarate aminotransferase, NADPH oxidizing activity" EXACT [EC:1.4.1.13] synonym: "NADPH-dependent glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-glutamate synthase activity" EXACT [EC:1.4.1.13] synonym: "NADPH-linked glutamate synthase" EXACT [EC:1.4.1.13] xref: EC:1.4.1.13 xref: MetaCyc:GLUGLNSYN-PWY xref: MetaCyc:GLUTAMATESYN-RXN xref: MetaCyc:GLUTSYN-PWY is_a: GO:0045181 ! glutamate synthase activity, NADH or NADPH as acceptor [Term] id: GO:0004356 name: glutamate-ammonia ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + NH3 = ADP + phosphate + L-glutamine." [EC:6.3.1.2] subset: gosubset_prok synonym: "glutamine synthetase activity" EXACT [] synonym: "glutamylhydroxamic synthetase activity" EXACT [EC:6.3.1.2] synonym: "L-glutamate:ammonia ligase (ADP-forming)" EXACT [EC:6.3.1.2] synonym: "L-glutamine synthetase activity" EXACT [EC:6.3.1.2] xref: EC:6.3.1.2 xref: MetaCyc:GLUTAMINESYN-RXN xref: Reactome:10495 "glutamate-ammonia ligase activity" is_a: GO:0016211 ! ammonia ligase activity [Term] id: GO:0004357 name: glutamate-cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + L-cysteine = ADP + phosphate + gamma-L-glutamyl-L-cysteine." [EC:6.3.2.2] subset: gosubset_prok synonym: "gamma-glutamyl-L-cysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteine synthetase activity" EXACT [EC:6.3.2.2] synonym: "gamma-glutamylcysteinyl synthetase activity" EXACT [EC:6.3.2.2] synonym: "L-glutamate:L-cysteine gamma-ligase (ADP-forming) activity" EXACT [EC:6.3.2.2] xref: EC:6.3.2.2 xref: MetaCyc:GLUTCYSLIG-RXN xref: Reactome:10497 "glutamate-cysteine ligase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004358 name: glutamate N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + L-glutamate = L-ornithine + N-acetyl-L-glutamate." [EC:2.3.1.35] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamate-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic synthetase activity" EXACT [EC:2.3.1.35] synonym: "acetylglutamic-acetylornithine transacetylase activity" EXACT [EC:2.3.1.35] synonym: "acetylornithinase activity" BROAD [EC:2.3.1.35] synonym: "acetylornithine glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "alpha-N-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "glutamate acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "N-acetyl-L-glutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthase activity" BROAD [EC:2.3.1.35] synonym: "N-acetylglutamate synthetase activity" BROAD [EC:2.3.1.35] synonym: "N2-acetyl-L-ornithine:L-glutamate N-acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine acetyltransferase activity" EXACT [EC:2.3.1.35] synonym: "ornithine transacetylase activity" EXACT [EC:2.3.1.35] xref: EC:2.3.1.35 xref: MetaCyc:GLUTAMATE-N-ACETYLTRANSFERASE-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004359 name: glutaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH3." [EC:3.5.1.2] subset: gosubset_prok synonym: "glutaminase I" RELATED [EC:3.5.1.2] synonym: "glutamine aminohydrolase activity" EXACT [EC:3.5.1.2] synonym: "L-glutaminase activity" EXACT [EC:3.5.1.2] synonym: "L-glutamine amidohydrolase activity" EXACT [EC:3.5.1.2] xref: EC:3.5.1.2 xref: MetaCyc:GLUTAMIN-RXN xref: Reactome:10219 "glutaminase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004360 name: glutamine-fructose-6-phosphate transaminase (isomerizing) activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamine + D-fructose 6-phosphate = L-glutamate + D-glucosamine 6-phosphate." [EC:2.6.1.16] subset: gosubset_prok synonym: "D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "GlcN6P synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine 6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosamine--fructose-6-phosphate aminotransferase (isomerizing) activity" EXACT [EC:2.6.1.16] synonym: "glucosamine-6-phosphate isomerase (glutamine-forming) activity" EXACT [] synonym: "glucosamine-6-phosphate synthase activity" EXACT [EC:2.6.1.16] synonym: "glucosaminephosphate isomerase" BROAD [EC:2.6.1.16] synonym: "hexosephosphate aminotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine-D-fructose-6-phosphate amidotransferase activity" EXACT [EC:2.6.1.16] synonym: "L-glutamine:D-fructose-6-phosphate isomerase (deaminating)" EXACT [EC:2.6.1.16] xref: EC:2.6.1.16 xref: MetaCyc:L-GLN-FRUCT-6-P-AMINOTRANS-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004361 name: glutaryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glutaryl-CoA + acceptor = crotonoyl-CoA + CO2 + reduced acceptor." [EC:1.3.99.7] subset: gosubset_prok synonym: "glutaryl coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:(acceptor) 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] synonym: "glutaryl-CoA:acceptor 2,3-oxidoreductase (decarboxylating)" EXACT [EC:1.3.99.7] xref: EC:1.3.99.7 xref: MetaCyc:GLUTARYL-COA-DEHYDROGENASE-RXN xref: Reactome:10507 "glutaryl-CoA dehydrogenase activity" xref: UM-BBD_enzymeID:e0123 is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004362 name: glutathione-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+." [EC:1.8.1.7, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this function was formerly EC:1.6.4.2. subset: gosubset_prok synonym: "glutathione reductase (NADPH) activity" EXACT [] synonym: "glutathione reductase activity" EXACT [] synonym: "glutathione S-reductase activity" EXACT [EC:1.8.1.7] synonym: "glutathione-disulphide reductase activity" EXACT [] synonym: "glutathione:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "GSH reductase activity" EXACT [EC:1.8.1.7] synonym: "GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-glutathione reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH-GSSG reductase activity" EXACT [EC:1.8.1.7] synonym: "NADPH:oxidized-glutathione oxidoreductase activity" EXACT [EC:1.8.1.7] synonym: "oxidized glutathione reduction" RELATED [] xref: EC:1.8.1.7 xref: MetaCyc:GLUTATHIONE-REDUCT-NADPH-RXN xref: Reactome:10508 "glutathione-disulfide reductase activity" is_a: GO:0015038 ! glutathione disulfide oxidoreductase activity is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004363 name: glutathione synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + gamma-L-glutamyl-L-cysteine + glycine = ADP + phosphate + glutathione." [EC:6.3.2.3] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteine:glycine ligase (ADP-forming)" EXACT [EC:6.3.2.3] synonym: "glutathione synthetase activity" EXACT [EC:6.3.2.3] synonym: "GSH synthetase activity" EXACT [EC:6.3.2.3] xref: EC:6.3.2.3 xref: MetaCyc:GLUTATHIONE-SYN-RXN xref: Reactome:10524 "glutathione synthase activity" is_a: GO:0016881 ! acid-amino acid ligase activity relationship: part_of GO:0006750 ! glutathione biosynthetic process [Term] id: GO:0004364 name: glutathione transferase activity namespace: molecular_function def: "Catalysis of the reaction: R-X + glutathione = H-X + R-S-glutathione. R may be an aliphatic, aromatic or heterocyclic group; X may be a sulfate, nitrile or halide group." [EC:2.5.1.18] subset: gosubset_prok synonym: "glutathione conjugation reaction" EXACT [] synonym: "glutathione S-alkyl transferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-alkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aralkyltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-aryltransferase activity" EXACT [EC:2.5.1.18] synonym: "glutathione S-transferase activity" EXACT [EC:2.5.1.18] synonym: "RX:glutathione R-transferase activity" EXACT [EC:2.5.1.18] synonym: "S-(hydroxyalkyl)glutathione lyase activity" EXACT [EC:2.5.1.18] xref: EC:2.5.1.18 xref: MetaCyc:GSHTRAN-RXN xref: Reactome:10527 "glutathione transferase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004365 name: glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + phosphate + NAD+ = 3-phospho-D-glyceroyl phosphate + NADH + H+." [EC:1.2.1.12] subset: gosubset_prok synonym: "3-phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "D-glyceraldehyde-3-phosphate:NAD+ oxidoreductase (phosphorylating)" EXACT [EC:1.2.1.12] synonym: "dehydrogenase, glyceraldehyde phosphate" EXACT [EC:1.2.1.12] synonym: "GAPDH activity" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde phosphate dehydrogenase (NAD)" EXACT [EC:1.2.1.12] synonym: "glyceraldehyde-3-P-dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NAD-dependent glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "NADH-glyceraldehyde phosphate dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "phosphoglyceraldehyde dehydrogenase activity" EXACT [EC:1.2.1.12] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.12] xref: EC:1.2.1.12 xref: MetaCyc:GAPOXNPHOSPHN-RXN xref: Reactome:10530 "glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) activity" is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0004366 name: glycerol-3-phosphate O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + sn-glycerol 3-phosphate = CoA + 1-acyl-sn-glycerol 3-phosphate." [EC:2.3.1.15] subset: gosubset_prok synonym: "3-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "ACP:sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "acyl-CoA:sn-glycerol-3-phosphate 1-O-acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "alpha-glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerol phosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "glycerophosphate transacylase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol 3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] synonym: "sn-glycerol-3-phosphate acyltransferase activity" EXACT [EC:2.3.1.15] xref: EC:2.3.1.15 xref: MetaCyc:RXN-1381 xref: Reactome:10531 "glycerol-3-phosphate O-acyltransferase activity" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004367 name: glycerol-3-phosphate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + NAD+ = glycerone phosphate + NADH + H+." [EC:1.1.1.8] subset: gosubset_prok synonym: "alpha-glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "alpha-glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol 1-phosphate dehydrogenase activity" RELATED [EC:1.1.1.8] synonym: "glycerol phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerol-3-phosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "glycerophosphate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.8] synonym: "hydroglycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-alpha-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "L-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-alpha-glycerophosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-dependent glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-L-glycerol-3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NAD-linked glycerol 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.8] synonym: "NADH-dihydroxyacetone phosphate reductase activity" RELATED [EC:1.1.1.8] xref: EC:1.1.1.8 xref: MetaCyc:1.1.1.8-RXN xref: Reactome:10533 "glycerol-3-phosphate dehydrogenase (NAD+) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004368 name: glycerol-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + acceptor = glycerone phosphate + reduced acceptor." [EC:1.1.99.5] subset: gosubset_prok synonym: "alpha-glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "alpha-glycerophosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] synonym: "dehydrogenase, glycerol phosphate (acceptor)" EXACT [EC:1.1.99.5] synonym: "DL-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] synonym: "FAD-dependent glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-dependent sn-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-linked glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "FAD-linked L-glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "flavin-linked glycerol-3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "flavoprotein-linked L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "glycerol 3-phosphate cytochrome c reductase" NARROW [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase (acceptor)" EXACT [EC:1.1.99.5] synonym: "glycerol phosphate dehydrogenase (FAD)" NARROW [EC:1.1.99.5] synonym: "glycerol-3-phosphate dehydrogenase (flavin-linked)" NARROW [EC:1.1.99.5] synonym: "glycerophosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "L-3-glycerophosphate-ubiquinone oxidoreductase" EXACT [EC:1.1.99.5] synonym: "L-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "NAD-independent glycerol phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "pyridine nucleotide-independent L-glycerol 3-phosphate dehydrogenase" NARROW [EC:1.1.99.5] synonym: "sn-glycerol 3-phosphate oxidase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate dehydrogenase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate:(acceptor) 2-oxidoreductase" EXACT [EC:1.1.99.5] synonym: "sn-glycerol-3-phosphate:acceptor 2-oxidoreductase" EXACT [EC:1.1.99.5] xref: EC:1.1.99.5 xref: MetaCyc:GLYC3PDEHYDROG-RXN xref: MetaCyc:RXN-9927 xref: MetaCyc:RXN0-5258 xref: MetaCyc:RXN0-5260 xref: Reactome:10535 "glycerol-3-phosphate dehydrogenase activity" is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004369 name: glycerol-3-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sn-glycerol 3-phosphate + O2 = glycerone phosphate + H2O2." [EC:1.1.3.21] subset: gosubset_prok synonym: "alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "glycerol-1-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerol-3-phosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "L-alpha-glycerophosphate oxidase activity" EXACT [EC:1.1.3.21] synonym: "sn-glycerol-3-phosphate:oxygen 2-oxidoreductase activity" EXACT [EC:1.1.3.21] xref: EC:1.1.3.21 xref: MetaCyc:GLYCEROL-3-PHOSPHATE-OXIDASE-RXN is_a: GO:0016899 ! oxidoreductase activity, acting on the CH-OH group of donors, oxygen as acceptor [Term] id: GO:0004370 name: glycerol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerol = ADP + glycerol 3-phosphate." [EC:2.7.1.30] subset: gosubset_prok synonym: "ATP:glycerol 3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "ATP:glycerol-3-phosphotransferase activity" EXACT [EC:2.7.1.30] synonym: "GK" RELATED [EC:2.7.1.30] synonym: "glyceric kinase activity" EXACT [EC:2.7.1.30] synonym: "glycerokinase activity" EXACT [EC:2.7.1.30] synonym: "glycerol kinase (phosphorylating)" EXACT [EC:2.7.1.30] xref: EC:2.7.1.30 xref: MetaCyc:GLYCEROL-KIN-RXN xref: Reactome:10545 "glycerol kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004371 name: glycerone kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate." [EC:2.7.1.29] subset: gosubset_prok synonym: "acetol kinase (phosphorylating)" EXACT [EC:2.7.1.29] synonym: "acetol kinase activity" EXACT [EC:2.7.1.29] synonym: "ATP:glycerone phosphotransferase activity" EXACT [EC:2.7.1.29] synonym: "dihydroxyacetone kinase activity" EXACT [EC:2.7.1.29] xref: EC:2.7.1.29 xref: MetaCyc:GLYCERONE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004372 name: glycine hydroxymethyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + glycine + H2O = tetrahydrofolate + L-serine." [EC:2.1.2.1] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:glycine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "allothreonine aldolase activity" EXACT [EC:2.1.2.1] synonym: "L-serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine aldolase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethylase activity" EXACT [EC:2.1.2.1] synonym: "serine hydroxymethyltransferase activity" EXACT [EC:2.1.2.1] synonym: "serine transhydroxymethylase activity" EXACT [EC:2.1.2.1] xref: EC:2.1.2.1 xref: MetaCyc:GLYOHMETRANS-RXN xref: Reactome:1060 "glycine hydroxymethyltransferase activity" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0004373 name: glycogen (starch) synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + (1,4)-alpha-D-glucosyl(n) = UDP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.11] subset: gosubset_prok synonym: "glycogen (starch) synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "UDP-glycogen synthase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen synthetase activity" EXACT [EC:2.4.1.11] synonym: "UDPG-glycogen transglucosylase activity" EXACT [EC:2.4.1.11] synonym: "UDPglucose:glycogen 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.11] synonym: "uridine diphosphoglucose-glycogen glucosyltransferase activity" EXACT [EC:2.4.1.11] xref: EC:2.4.1.11 xref: MetaCyc:2.4.1.11-RXN xref: Reactome:10552 "glycogen (starch) synthase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004374 name: glycine cleavage system namespace: molecular_function def: "OBSOLETE. Catalysis of the reactions glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + carbon dioxide (CO2), followed by S-aminomethyldihydrolipoylprotein + (6S)-tetrahydrofolate = dihydrolipoylprotein + (6R)-5,10-methylenetetrahydrofolate + ammonia. Made up of two components, aminomethyltransferase and glycine dehydrogenase (decarboxylating)." [EC:1.4.4.2, EC:2.1.2.10] comment: This term was made obsolete because it represents a process rather than a function. synonym: "glycine synthase" BROAD [] is_obsolete: true replaced_by: GO:0019464 [Term] id: GO:0004375 name: glycine dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: glycine + lipoylprotein = S-aminomethyldihydrolipoylprotein + CO2." [EC:1.4.4.2] subset: gosubset_prok synonym: "glycine cleavage system P-protein activity" NARROW [EC:1.4.4.2] synonym: "glycine decarboxylase activity" EXACT [EC:1.4.4.2] synonym: "glycine-cleavage complex" RELATED [EC:1.4.4.2] synonym: "glycine-cleavage complex P-protein activity" EXACT [EC:1.4.4.2] synonym: "glycine:H-protein-lipoyllysine oxidoreductase (decarboxylating, acceptor-amino-methylating)" EXACT [EC:1.4.4.2] synonym: "glycine:lipoylprotein oxidoreductase (decarboxylating and acceptor-aminomethylating)" EXACT [EC:1.4.4.2] synonym: "P-protein" NARROW [EC:1.4.4.2] synonym: "protein P1" NARROW [EC:1.4.4.2] xref: EC:1.4.4.2 xref: MetaCyc:GCVP-RXN is_a: GO:0016642 ! oxidoreductase activity, acting on the CH-NH2 group of donors, disulfide as acceptor [Term] id: GO:0004376 name: glycolipid mannosyltransferase activity namespace: molecular_function alt_id: GO:0004580 def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-D-mannosyl-D-mannose linkage." [GOC:ai] synonym: "glycolipid mannosyl transferase activity" EXACT [] xref: EC:2.4.1.- xref: Reactome:10559 "glycolipid mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004377 name: glycolipid 2-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,2-D-mannosyl-D-mannose linkage." [EC:2.4.1.131] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "GDP-mannose:glycolipid 1,2-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "guanosine diphosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] synonym: "oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.131] xref: EC:2.4.1.131 xref: MetaCyc:2.4.1.131-RXN is_a: GO:0000026 ! alpha-1,2-mannosyltransferase activity is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004378 name: glycolipid 3-alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-1,3-D-mannosyl-D-mannose linkage." [EC:2.4.1.132] synonym: "GDP-mannose-oligosaccharide-lipid mannosyltransferase II" RELATED [EC:2.4.1.132] synonym: "GDP-mannose:glycolipid 1,3-alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "guanosine diphosphomannose-oligosaccharide-lipid II mannosyltransferase activity" EXACT [EC:2.4.1.132] synonym: "mannosyltransferase II activity" EXACT [EC:2.4.1.132] xref: EC:2.4.1.132 xref: MetaCyc:2.4.1.132-RXN is_a: GO:0004376 ! glycolipid mannosyltransferase activity [Term] id: GO:0004379 name: glycylpeptide N-tetradecanoyltransferase activity namespace: molecular_function alt_id: GO:0019106 def: "Catalysis of the reaction: tetradecanoyl-CoA + glycyl-peptide = CoA + N-tetradecanoylglycyl-peptide." [EC:2.3.1.97] synonym: "myristoyl-CoA-protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "myristoyl-coenzyme A:protein N-myristoyl transferase activity" EXACT [EC:2.3.1.97] synonym: "myristoylating enzymes" RELATED [EC:2.3.1.97] synonym: "N-myristoyltransferase activity" EXACT [] synonym: "peptide N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "peptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "protein N-myristoyltransferase activity" EXACT [EC:2.3.1.97] synonym: "tetradecanoyl-CoA:glycylpeptide N-tetradecanoyltransferase activity" EXACT [EC:2.3.1.97] xref: EC:2.3.1.97 xref: MetaCyc:2.3.1.97-RXN is_a: GO:0016410 ! N-acyltransferase activity is_a: GO:0019107 ! myristoyltransferase activity [Term] id: GO:0004380 name: glycoprotein-fucosylgalactoside alpha-N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-N-acetyl-alpha-D-galactosaminyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.40] synonym: "A transferase activity" RELATED [EC:2.4.1.40] synonym: "A-transferase activity" EXACT [EC:2.4.1.40] synonym: "alpha-3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance A-dependent acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "blood-group substance alpha-acetyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylgalactose alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "fucosylglycoprotein alpha-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "histo-blood group A acetylgalactosaminyltransferase activity" NARROW [EC:2.4.1.40] synonym: "histo-blood group A glycosyltransferase (Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase)" EXACT [EC:2.4.1.40] synonym: "histo-blood group A transferase activity" RELATED [EC:2.4.1.40] synonym: "UDP-GalNAc:Fucalpha1->2Galalpha1->3-N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:alpha-L-fucosyl-1,2-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] synonym: "UDP-N-acetyl-D-galactosamine:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-N-acetyl-D-galactosaminyltransferase activity" EXACT [EC:2.4.1.40] xref: EC:2.4.1.40 xref: MetaCyc:2.4.1.40-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0004381 name: fucosylgalactoside 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose = UDP + glycoprotein-alpha-D-galactosyl-(1,3)-(alpha-L-fucosyl-(1,2))-D-galactose." [EC:2.4.1.37] synonym: "[blood group substance] alpha-galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "B transferase activity" RELATED [EC:2.4.1.37] synonym: "blood-group substance B-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "blood-group substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "fucosylglycoprotein 3-alpha-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "glycoprotein-fucosylgalactoside alpha-galactosyltransferase activity" EXACT [] synonym: "histo-blood group B transferase activity" NARROW [EC:2.4.1.37] synonym: "histo-blood substance B-dependent galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "histo-blood substance beta-dependent galactosyltransferase activity" NARROW [EC:2.4.1.37] synonym: "UDP-galactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:alpha-L-fucosyl-(1->2)-D-galactoside 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:glycoprotein-alpha-L-fucosyl-(1,2)-D-galactose 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] synonym: "UDPgalactose:O-alpha-L-fucosyl(1->2)D-galactose alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.37] xref: EC:2.4.1.37 xref: MetaCyc:2.4.1.37-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004382 name: guanosine-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: GDP + H2O = GMP + phosphate." [EC:3.6.1.42, PMID:2989286] synonym: "GDP phosphohydrolase activity" EXACT [EC:3.6.1.42] synonym: "GDPase activity" EXACT [EC:3.6.1.42] synonym: "guanosine 5'-diphosphatase activity" EXACT [EC:3.6.1.6] synonym: "guanosine diphosphatase activity" EXACT [] xref: EC:3.6.1.42 xref: MetaCyc:GUANOSINE-DIPHOSPHATASE-RXN is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004383 name: guanylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] subset: gosubset_prok synonym: "GTP diphosphate-lyase (cyclizing) activity" EXACT [EC:4.6.1.2] synonym: "GTP diphosphate-lyase (cyclizing; 3',5'-cyclic-GMP-forming) activity" EXACT [EC:4.6.1.2] synonym: "guanyl cyclase activity" EXACT [EC:4.6.1.2] synonym: "guanylyl cyclase activity" EXACT [] synonym: "receptor guanylate cyclase activity" NARROW [] xref: EC:4.6.1.2 xref: MetaCyc:GUANYLCYC-RXN is_a: GO:0009975 ! cyclase activity is_a: GO:0016849 ! phosphorus-oxygen lyase activity relationship: part_of GO:0006182 ! cGMP biosynthetic process [Term] id: GO:0004384 name: membrane-associated guanylate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + GMP = ADP + GDP, associated with the cell membrane." [EC:2.7.4.8] comment: This term was made obsolete because it represents a gene product and not a function. synonym: "MAGUK" EXACT [] is_obsolete: true consider: GO:0004385 consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0050839 [Term] id: GO:0004385 name: guanylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GMP = ADP + GDP." [EC:2.7.4.8] subset: gosubset_prok synonym: "5'-GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "ATP:(d)GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "ATP:GMP phosphotransferase activity" EXACT [EC:2.7.4.8] synonym: "deoxyguanylate kinase activity" RELATED [EC:2.7.4.8] synonym: "GMP kinase activity" EXACT [EC:2.7.4.8] synonym: "guanosine monophosphate kinase activity" EXACT [EC:2.7.4.8] synonym: "membrane-associated guanylate kinase" NARROW [] xref: EC:2.7.4.8 xref: MetaCyc:GUANYL-KIN-RXN xref: Reactome:10583 "guanylate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004386 name: helicase activity namespace: molecular_function def: "Catalysis of the reaction: NTP + H2O = NDP + phosphate to drive the unwinding of a DNA or RNA helix." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that most helicases catalyze processive duplex unwinding. subset: goslim_candida subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok xref: Reactome:7001 "helicase activity" is_a: GO:0017111 ! nucleoside-triphosphatase activity [Term] id: GO:0004392 name: heme oxygenase (decyclizing) activity namespace: molecular_function def: "Catalysis of the reaction: heme + 3 donor-H2 + 3 O2 = biliverdin + Fe2+ + CO + 3 acceptor + 3 H2O." [EC:1.14.99.3] synonym: "haem oxidase activity" EXACT [EC:1.14.99.3] synonym: "haem oxygenase (decyclizing) activity" EXACT [] synonym: "haem oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme oxidase activity" EXACT [EC:1.14.99.3] synonym: "heme oxygenase activity" EXACT [EC:1.14.99.3] synonym: "heme,hydrogen-donor:oxygen oxidoreductase (alpha-methene-oxidizing, hydroxylating)" EXACT [EC:1.14.99.3] synonym: "ORP33 proteins" RELATED [EC:1.14.99.3] xref: EC:1.14.99.3 xref: MetaCyc:HEME-OXYGENASE-DECYCLIZING-RXN is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004394 name: heparan sulfate 2-O-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + heparan sulfate = adenosine 3',5'-bisphosphate + heparan sulfate 2-O-sulfate; results in 2-O-sulfation of iduronic acid residues in heparan sulfate." [PMID:9153262] synonym: "heparan-sulfate 2-O-sulphotransferase activity" EXACT [] synonym: "heparin 2-sulfotransferase activity" RELATED [] synonym: "heparin-sulphate 2-sulphotransferase activity" RELATED [] xref: EC:2.8.2.- is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0004395 name: hexaprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-hexaprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-hexaprenyl-4-hydroxy-5-methoxybenzoate." [EC:2.1.1.114] synonym: "3,4-dihydroxy-5-hexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "DHHB-Mt activity" EXACT [EC:2.1.1.114] synonym: "dihydroxyhexaprenylbenzoate methyltransferase activity" EXACT [EC:2.1.1.114] synonym: "S-adenosyl-L-methionine:3-hexaprenyl-4,5-dihydroxylate O-methyltransferase activity" EXACT [EC:2.1.1.114] xref: EC:2.1.1.114 xref: MetaCyc:2.1.1.114-RXN is_a: GO:0010420 ! polyprenyldihydroxybenzoate methyltransferase activity [Term] id: GO:0004396 name: hexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate." [EC:2.7.1.1] subset: gosubset_prok synonym: "ATP-dependent hexokinase activity" EXACT [EC:2.7.1.1] synonym: "ATP:D-hexose 6-phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "glucose ATP phosphotransferase activity" EXACT [EC:2.7.1.1] synonym: "hexokinase (phosphorylating)" EXACT [EC:2.7.1.1] synonym: "hexokinase D" RELATED [EC:2.7.1.1] synonym: "hexokinase type I activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type II activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type III activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV" RELATED [EC:2.7.1.1] synonym: "hexokinase type IV (glucokinase) activity" NARROW [EC:2.7.1.1] synonym: "hexokinase type IV glucokinase activity" EXACT [EC:2.7.1.1] xref: EC:2.7.1.1 xref: MetaCyc:HEXOKINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004397 name: histidine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = urocanate + NH3." [EC:4.3.1.3] subset: gosubset_prok synonym: "histidase activity" RELATED [GOC:hjd] synonym: "histidinase activity" RELATED [GOC:hjd] synonym: "histidine alpha-deaminase activity" RELATED [GOC:hjd] synonym: "L-histidine ammonia-lyase (urocanate-forming)" EXACT [EC:4.3.1.3] synonym: "L-histidine ammonia-lyase activity" EXACT [EC:4.3.1.3] xref: EC:4.3.1.3 xref: MetaCyc:HISTIDINE-AMMONIA-LYASE-RXN xref: Reactome:10604 "histidine ammonia-lyase activity" is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004398 name: histidine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine = histamine + CO2." [EC:4.1.1.22] subset: gosubset_prok synonym: "L-histidine carboxy-lyase (histamine-forming)" EXACT [EC:4.1.1.22] synonym: "L-histidine carboxy-lyase activity" EXACT [EC:4.1.1.22] synonym: "L-histidine decarboxylase activity" EXACT [EC:4.1.1.22] xref: EC:4.1.1.22 xref: MetaCyc:HISTIDINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004399 name: histidinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol + NAD+ = L-histidine + NADH + H+." [EC:1.1.1.23] subset: gosubset_prok xref: EC:1.1.1.23 xref: MetaCyc:HISTALDEHYD-RXN xref: MetaCyc:HISTOLDEHYD-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004400 name: histidinol-phosphate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + 2-oxoglutarate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + L-glutamate." [EC:2.6.1.9] subset: gosubset_prok synonym: "glutamic-imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidine:imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "histidinol-phosphate aminotransferase activity" EXACT [] synonym: "IAP transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazole acetol-phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazoleacetol phosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "imidazolylacetolphosphate transaminase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol phosphate aminotransferase activity" EXACT [EC:2.6.1.9] synonym: "L-histidinol-phosphate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.9] xref: EC:2.6.1.9 xref: MetaCyc:HISTAMINOTRANS-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004401 name: histidinol-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidinol-phosphate + H2O = L-histidinol + phosphate." [EC:3.1.3.15] subset: gosubset_prok synonym: "histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphatase activity" EXACT [EC:3.1.3.15] synonym: "histidinolphosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "HPpase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol phosphate phosphatase activity" EXACT [EC:3.1.3.15] synonym: "L-histidinol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.15] xref: EC:3.1.3.15 xref: MetaCyc:HISTIDPHOS-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004402 name: histone acetyltransferase activity namespace: molecular_function alt_id: GO:0004403 alt_id: GO:0004404 alt_id: GO:0004405 alt_id: GO:0004406 alt_id: GO:0043166 alt_id: GO:0046971 def: "Catalysis of the reaction: acetyl-CoA + histone = CoA + acetyl-histone." [EC:2.3.1.48] comment: Note that the term 'histone lysine acetyltransferase activity ; GO:0046971' was merged into this term because only lysine residues are ever acetylated in histones, and so the term was redundant. synonym: "acetyl-CoA:histone acetyltransferase activity" EXACT [EC:2.3.1.48] synonym: "H2A/H2B histone acetyltransferase activity" NARROW [] synonym: "H3/H4 histone acetyltransferase activity" NARROW [] synonym: "H4/H2 histone acetyltransferase activity" NARROW [] synonym: "H4/H2A acetyltransferase activity" NARROW [] synonym: "histone acetokinase activity" EXACT [EC:2.3.1.48] synonym: "histone acetylase activity" EXACT [] synonym: "histone lysine acetyltransferase activity" EXACT [] synonym: "histone transacetylase activity" EXACT [EC:2.3.1.48] synonym: "nucleosome-histone acetyltransferase activity" RELATED [EC:2.3.1.48] xref: EC:2.3.1.48 xref: MetaCyc:HISTONE-ACETYLTRANSFERASE-RXN is_a: GO:0004468 ! lysine N-acetyltransferase activity [Term] id: GO:0004407 name: histone deacetylase activity namespace: molecular_function def: "Catalysis of the hydrolysis of acetyl groups from histones, proteins complexed to DNA in chromatin and chromosomes." [EC:3.5.1.-, http://cancerweb.ncl.ac.uk/] xref: EC:3.5.1.- xref: MetaCyc:3.5.1.98-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0033558 ! protein deacetylase activity [Term] id: GO:0004408 name: holocytochrome-c synthase activity namespace: molecular_function def: "Catalysis of the reaction: holocytochrome c = apocytochrome c + heme." [EC:4.4.1.17] subset: gosubset_prok synonym: "cytochrome c heme-lyase activity" EXACT [EC:4.4.1.17] synonym: "cytochrome c synthase activity" RELATED [EC:4.4.1.17] synonym: "holocytochrome c synthetase activity" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase (heme-forming)" EXACT [EC:4.4.1.17] synonym: "holocytochrome-c apocytochrome-c-lyase activity" EXACT [EC:4.4.1.17] xref: EC:4.4.1.17 xref: MetaCyc:HOLOCYTOCHROME-C-SYNTHASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004409 name: homoaconitate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-hydroxybutane-1,2,4-tricarboxylate = but-1-ene-1,2,4-tricarboxylate + H2O." [EC:4.2.1.36] subset: gosubset_prok synonym: "(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate hydro-lyase [(Z)-but-1-ene-1,2,4-tricarboxylate-forming]" RELATED [EC:4.2.1.36] synonym: "2-hydroxybutane-1,2,4-tricarboxylate hydro-lyase activity" EXACT [EC:4.2.1.36] synonym: "cis-homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "HACN activity" EXACT [EC:4.2.1.36] synonym: "homoaconitase activity" EXACT [EC:4.2.1.36] synonym: "Lys4" RELATED [EC:4.2.1.36] synonym: "LysF" RELATED [EC:4.2.1.36] xref: EC:4.2.1.36 xref: MetaCyc:HOMOACONITATE-HYDRATASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004410 name: homocitrate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + 2-oxoglutarate = 2-hydroxybutane-1,2,4-tricarboxylate + CoA." [EC:2.3.3.14] comment: Note that this function was formerly EC:4.1.3.21. subset: gosubset_prok synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.14] synonym: "2-hydroxybutane-1,2,4-tricarboxylate 2-oxoglutarate-lyase (CoA-acetylating)" EXACT [EC:2.3.3.14] synonym: "acetyl-CoA:2-oxoglutarate C-acetyltransferase (thioester-hydrolysing, carboxymethyl forming)" EXACT [EC:2.3.3.14] synonym: "acetyl-coenzyme A:2-ketoglutarate C-acetyl transferase activity" EXACT [EC:2.3.3.14] synonym: "homocitrate synthetase activity" EXACT [EC:2.3.3.14] xref: EC:2.3.3.14 xref: MetaCyc:HOMOCITRATE-SYNTHASE-RXN is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004411 name: homogentisate 1,2-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisate + O2 = 4-maleylacetoacetate." [EC:1.13.11.5] subset: gosubset_prok synonym: "homogentisate dioxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisate:oxygen 1,2-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxidase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic acid oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisic oxygenase activity" EXACT [EC:1.13.11.5] synonym: "homogentisicase activity" EXACT [EC:1.13.11.5] xref: EC:1.13.11.5 xref: MetaCyc:HOMOGENTISATE-12-DIOXYGENASE-RXN xref: Reactome:11355 "homogentisate 1,2-dioxygenase activity" xref: UM-BBD_enzymeID:e0081 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004412 name: homoserine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-homoserine + NADP+ = L-aspartate-4-semialdehyde + NADPH + H+." [EC:1.1.1.3] subset: gosubset_prok xref: EC:1.1.1.3 xref: MetaCyc:HOMOSERDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004413 name: homoserine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-homoserine = ADP + O-phospho-L-homoserine." [EC:2.7.1.39] subset: gosubset_prok synonym: "ATP:L-homoserine O-phosphotransferase activity" EXACT [EC:2.7.1.39] synonym: "homoserine kinase (phosphorylating)" EXACT [EC:2.7.1.39] synonym: "HSK" RELATED [EC:2.7.1.39] xref: EC:2.7.1.39 xref: MetaCyc:HOMOSERKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019202 ! amino acid kinase activity [Term] id: GO:0004414 name: homoserine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-homoserine = CoA + O-acetyl-L-homoserine." [EC:2.3.1.31] subset: gosubset_prok synonym: "acetyl-CoA:L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine acetyltransferase activity" EXACT [EC:2.3.1.31] synonym: "homoserine O-trans-acetylase activity" EXACT [EC:2.3.1.31] synonym: "homoserine transacetylase activity" BROAD [EC:2.3.1.31] synonym: "homoserine-O-transacetylase activity" EXACT [EC:2.3.1.31] synonym: "L-homoserine O-acetyltransferase activity" EXACT [EC:2.3.1.31] xref: EC:2.3.1.31 xref: MetaCyc:HOMOSERINE-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0004415 name: hyalurononglucosaminidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-linkages between N-acetyl-beta-D-glucosamine and D-glucuronate residues in hyaluronate." [EC:3.2.1.35] subset: gosubset_prok synonym: "chondroitinase activity" BROAD [EC:3.2.1.35] synonym: "chondroitinase I activity" EXACT [EC:3.2.1.35] synonym: "hyaluronate 4-glycanohydrolase activity" EXACT [EC:3.2.1.35] synonym: "hyaluronidase activity" BROAD [EC:3.2.1.35] synonym: "hyaluronoglucosaminidase activity" EXACT [] synonym: "hyaluronoglucosidase activity" EXACT [EC:3.2.1.35] xref: EC:3.2.1.35 xref: MetaCyc:3.2.1.35-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004416 name: hydroxyacylglutathione hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate." [EC:3.1.2.6] subset: gosubset_prok synonym: "acetoacetylglutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "glyoxalase II activity" EXACT [EC:3.1.2.6] synonym: "S-(2-hydroxyacyl)glutathione hydrolase activity" EXACT [EC:3.1.2.6] synonym: "S-2-hydroxylacylglutathione hydrolase activity" EXACT [EC:3.1.2.6] xref: EC:3.1.2.6 xref: MetaCyc:GLYOXII-RXN is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0004417 name: hydroxyethylthiazole kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-methyl-5-(2-hydroxyethyl)-thiazole = ADP + 4-methyl-5-(2-phosphoethyl)-thiazole." [EC:2.7.1.50] subset: gosubset_prok synonym: "4-methyl-5-(beta-hydroxyethyl)thiazole kinase activity" EXACT [EC:2.7.1.50] synonym: "ATP:4-methyl-5-(2-hydroxyethyl)thiazole 2-phosphotransferase activity" EXACT [EC:2.7.1.50] synonym: "hydroxyethylthiazole kinase (phosphorylating)" EXACT [EC:2.7.1.50] xref: EC:2.7.1.50 xref: MetaCyc:THIAZOLSYN3-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004418 name: hydroxymethylbilane synthase activity namespace: molecular_function def: "Catalysis of the reaction: 4 porphobilinogen + H2O = hydroxymethylbilane + 4 NH3." [EC:2.5.1.61] comment: Note that this function was formerly EC:4.3.1.8. subset: gosubset_prok synonym: "(4-(2-carboxyethyl)-3-(carboxymethyl)pyrrol-2-yl)methyltransferase (hydrolyzing) activity" EXACT [EC:2.5.1.61] synonym: "(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "HMB-synthase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen ammonia-lyase (polymerizing)" EXACT [EC:2.5.1.61] synonym: "porphobilinogen deaminase activity" EXACT [EC:2.5.1.61] synonym: "porphobilinogen:(4-[2-carboxyethyl]-3-[carboxymethyl]pyrrol-2-yl)methyltransferase (hydrolysing)" EXACT [EC:2.5.1.61] synonym: "pre-uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen I synthase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen I synthetase activity" NARROW [EC:2.5.1.61] synonym: "uroporphyrinogen synthase activity" EXACT [EC:2.5.1.61] synonym: "uroporphyrinogen synthetase activity" EXACT [EC:2.5.1.61] xref: EC:2.5.1.61 xref: MetaCyc:OHMETHYLBILANESYN-RXN xref: Reactome:11374 "hydroxymethylbilane synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004419 name: hydroxymethylglutaryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = acetyl-CoA + acetoacetate." [EC:4.1.3.4] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.4] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetate-lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutarate-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl CoA cleaving enzyme" RELATED [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "3-hydroxy-3-methylglutaryl-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "HMG-CoA lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A lyase activity" EXACT [EC:4.1.3.4] synonym: "hydroxymethylglutaryl coenzyme A-cleaving enzyme" RELATED [EC:4.1.3.4] xref: EC:4.1.3.4 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-LYASE-RXN xref: Reactome:74178 "hydroxymethylglutaryl-CoA lyase activity" is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004420 name: hydroxymethylglutaryl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + CoA + 2 NADP+ = (S)-3-hydroxy-3-methylglutaryl-CoA + 2 NADPH + 2 H+." [EC:1.1.1.34] subset: gosubset_prok synonym: "3-hydroxy-3-methylglutaryl-coenzyme A reductase activity" BROAD [EC:1.1.1.34] synonym: "HMG-CoA reductase activity" BROAD [EC:1.1.1.34] xref: EC:1.1.1.34 xref: MetaCyc:1.1.1.34-RXN xref: Reactome:11408 "hydroxymethylglutaryl-CoA reductase (NADPH) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004421 name: hydroxymethylglutaryl-CoA synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + acetoacetyl-CoA = (S)-3-hydroxy-3-methylglutaryl-CoA + CoA." [EC:2.3.3.10] comment: Note that this function was formerly EC:4.1.3.5. subset: gosubset_prok synonym: "(s)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA- acetylating) activity" EXACT [EC:2.3.3.10] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA acetoacetyl-CoA-lyase (CoA-acetylating)" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl CoA synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl coenzyme A synthetase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "3-hydroxy-3-methylglutaryl-coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "acetoacetyl coenzyme A transacetase activity" EXACT [EC:2.3.3.10] synonym: "acetyl-CoA:acetoacetyl-CoA C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.10] synonym: "beta-hydroxy-beta-methylglutaryl-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "HMG-CoA synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A synthase activity" EXACT [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme A-condensing enzyme" RELATED [EC:2.3.3.10] synonym: "hydroxymethylglutaryl coenzyme alpha-condensing enzyme activity" EXACT [EC:2.3.3.10] xref: EC:2.3.3.10 xref: MetaCyc:HYDROXYMETHYLGLUTARYL-COA-SYNTHASE-RXN xref: Reactome:74169 "hydroxymethylglutaryl-CoA synthase activity" is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004422 name: hypoxanthine phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: IMP + diphosphate = hypoxanthine + 5-phospho-alpha-D-ribose 1-diphosphate or GMP + diphosphate = guanine + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.8, GOC:curators] comment: Note that GO uses one molecular function term for consistency with Enzyme Nomenclature; also, all hypoxanthine phosphoribosyltransferases identified to date can act on either hypoxanthine or guanine, as well as xanthine or 6-mercaptopurine. subset: gosubset_prok synonym: "6-hydroxypurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "6-mercaptopurine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "GPRT" RELATED [EC:2.4.2.8] synonym: "guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanine-hypoxanthine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanosine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "guanylate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "guanylic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "HGPRTase activity" EXACT [EC:2.4.2.8] synonym: "HPRT" RELATED [EC:2.4.2.8] synonym: "hypoxanthine-guanine phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "IMP diphosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP-GMP pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "IMP:diphosphate phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "inosinate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic acid pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "inosinic pyrophosphorylase activity" EXACT [EC:2.4.2.8] synonym: "purine-6-thiol phosphoribosyltransferase activity" EXACT [EC:2.4.2.8] synonym: "Transphosphoribosidase activity" EXACT [EC:2.4.2.8] xref: EC:2.4.2.8 xref: MetaCyc:HYPOXANPRIBOSYLTRAN-RXN xref: Reactome:11410 "hypoxanthine phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004423 name: iduronate-2-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 2-sulfate groups of the L-iduronate 2-sulfate units of dermatan sulfate, heparan sulfate and heparin." [EC:3.1.6.13] subset: gosubset_prok synonym: "2-sulfo-L-iduronate 2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.13] synonym: "iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "iduronate-2-sulphatase activity" EXACT [] synonym: "iduronide-2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "idurono-2-sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate 2-sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronate-2-sulfate 2-sulfohydrolase activity" EXACT [EC:3.1.6.13] synonym: "L-idurono sulfate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "L-iduronosulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfo-L-iduronate sulfatase activity" EXACT [EC:3.1.6.13] synonym: "sulfoiduronate sulfohydrolase activity" EXACT [EC:3.1.6.13] xref: EC:3.1.6.13 xref: MetaCyc:3.1.6.13-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004424 name: imidazoleglycerol-phosphate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O." [EC:4.2.1.19] subset: gosubset_prok synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase [3-(imidazol-4-yl)-2-oxopropyl-phosphate-forming]" RELATED [EC:4.2.1.19] synonym: "D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate hydro-lyase activity" EXACT [EC:4.2.1.19] synonym: "IGP dehydratase activity" EXACT [EC:4.2.1.19] synonym: "imidazoleglycerol phosphate dehydratase activity" EXACT [] xref: EC:4.2.1.19 xref: MetaCyc:IMIDPHOSDEHYD-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004425 name: indole-3-glycerol-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate = 1-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O." [EC:4.1.1.48] subset: gosubset_prok synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase (cyclizing)" EXACT [EC:4.1.1.48] synonym: "1-(2-carboxyphenylamino)-1-deoxy-D-ribulose-5-phosphate carboxy-lyase [cyclizing; 1-C-(3-indolyl)-glycerol-3-phosphate-forming]" RELATED [EC:4.1.1.48] synonym: "indole-3-glycerophosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthase activity" EXACT [EC:4.1.1.48] synonym: "indoleglycerol phosphate synthetase activity" EXACT [EC:4.1.1.48] xref: EC:4.1.1.48 xref: MetaCyc:IGPSYN-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004427 name: inorganic diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + H2O = 2 phosphate." [EC:3.6.1.1] subset: gosubset_prok synonym: "diphosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] synonym: "inorganic pyrophosphatase activity" EXACT [EC:3.6.1.1] synonym: "pyrophosphate phosphohydrolase activity" EXACT [EC:3.6.1.1] xref: EC:3.6.1.1 xref: MetaCyc:INORGPYROPHOSPHAT-RXN xref: Reactome:11425 "inorganic diphosphatase activity" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004428 name: inositol or phosphatidylinositol kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol kinase activity" EXACT [] is_a: GO:0016301 ! kinase activity [Term] id: GO:0004430 name: 1-phosphatidylinositol 4-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol = ADP + 1-phosphatidyl-1D-myo-inositol 4-phosphate." [EC:2.7.1.67, PMID:9759495] synonym: "ATP:1-phosphatidyl-1D-myo-inositol 4-phosphotransferase activity" EXACT [EC:2.7.1.67] synonym: "phosphatidylinositol 4-kinase activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase (phosphorylating) activity" BROAD [EC:2.7.1.67] synonym: "phosphatidylinositol kinase activity" BROAD [EC:2.7.1.67] synonym: "PI 4-kinase activity" EXACT [EC:2.7.1.67] synonym: "PI kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4-kinase activity" BROAD [EC:2.7.1.67] synonym: "PI4K" BROAD [EC:2.7.1.67] synonym: "PI4K-alpha activity" BROAD [EC:2.7.1.67] synonym: "PtdIns-4-kinase activity" BROAD [EC:2.7.1.67] synonym: "type II phosphatidylinositol kinase activity" RELATED [EC:2.7.1.67] xref: EC:2.7.1.67 xref: MetaCyc:1-PHOSPHATIDYLINOSITOL-KINASE-RXN is_a: GO:0001727 ! lipid kinase activity is_a: GO:0004428 ! inositol or phosphatidylinositol kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor relationship: part_of GO:0046854 ! phosphoinositide phosphorylation [Term] id: GO:0004432 name: 1-phosphatidylinositol-4-phosphate kinase, class IA namespace: molecular_function def: "OBSOLETE. A class I PI3K activated by tyrosine phosphorylation events." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. is_obsolete: true consider: GO:0016308 [Term] id: GO:0004433 name: 1-phosphatidylinositol-4-phosphate kinase, class IB namespace: molecular_function def: "OBSOLETE. A class I PI3K activated via heterotrimeric G-proteins." [PMID:11050418] comment: This term was made obsolete because it is not a valid molecular function. is_obsolete: true consider: GO:0016308 [Term] id: GO:0004434 name: inositol or phosphatidylinositol phosphodiesterase activity namespace: molecular_function subset: gosubset_prok synonym: "inositol/phosphatidylinositol phosphodiesterase activity" EXACT [] xref: EC:3.1.4.- is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004435 name: phosphoinositide phospholipase C activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = D-myo-inositol 1,4,5-trisphosphate + diacylglycerol." [EC:3.1.4.11] subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity" EXACT [EC:3.1.4.11] synonym: "1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:3.1.4.11] synonym: "phosphatidylinositol phospholipase C activity" EXACT [EC:3.1.4.11] synonym: "phosphatidylinositol-4,5-bisphosphate hydrolysis" RELATED [] synonym: "phosphoinositidase C activity" EXACT [EC:3.1.4.11] synonym: "PI-PLC activity" EXACT [EC:3.1.4.11] synonym: "triphosphoinositide phosphodiesterase activity" BROAD [EC:3.1.4.11] xref: EC:3.1.4.11 xref: MetaCyc:3.1.4.11-RXN xref: Reactome:11456 "phosphoinositide phospholipase C activity" is_a: GO:0004434 ! inositol or phosphatidylinositol phosphodiesterase activity is_a: GO:0004629 ! phospholipase C activity [Term] id: GO:0004436 name: phosphatidylinositol diacylglycerol-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol = D-myo-inositol 1,2-cyclic phosphate + diacylglycerol." [EC:4.6.1.13] comment: Note that this function was formerly EC:3.1.4.10. subset: gosubset_prok synonym: "1-phosphatidyl-1D-myo-inositol diacyl-sn-glycerol-lyase (1D-myo-inositol-1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-1D-myo-inositol diacylglycerol-lyase (1,2-cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidyl-D-myo-inositol inositolphosphohydrolase (cyclic-phosphate-forming)" EXACT [EC:4.6.1.13] synonym: "1-phosphatidylinositol phosphodiesterase activity" EXACT [] synonym: "monophosphatidylinositol phosphodiesterase activity" BROAD [EC:4.6.1.13] xref: EC:4.6.1.13 xref: MetaCyc:3.1.4.10-RXN is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0004437 name: inositol or phosphatidylinositol phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a phosphate group from phosphorylated myo-inositol (1,2,3,5/4,6-cyclohexanehexol) or a phosphatidylinositol." [GOC:hb] subset: gosubset_prok synonym: "inositol/phosphatidylinositol phosphatase activity" EXACT [] is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004438 name: phosphatidylinositol-3-phosphatase activity namespace: molecular_function alt_id: GO:0016315 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate." [EC:3.1.3.64] comment: Note that this function includes EC:3.1.3.65. synonym: "1-phosphatidyl-1D-myo-inositol-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "D-myo-inositol-1,3-bisphosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] synonym: "inositol 1,3-bisphosphate phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,3-bisphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "inositol-1,4,-bisphosphate 3-phosphatase activity" EXACT [] synonym: "inositol-polyphosphate 3-phosphatase activity" EXACT [EC:3.1.3.64] synonym: "phosphatidyl-3-phosphate 3-phosphohydrolase activity" EXACT [EC:3.1.3.64] xref: EC:3.1.3.64 xref: MetaCyc:PHOSPHATIDYLINOSITOL-3-PHOSPHATASE-RXN is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity is_a: GO:0042577 ! lipid phosphatase activity [Term] id: GO:0004439 name: phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity namespace: molecular_function alt_id: GO:0001668 def: "Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.36] synonym: "inositol 1,4,5-triphosphate 5-phosphomonoesterase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidyl-myo-inositol-4,5-bisphosphate phosphatase activity" EXACT [EC:3.1.3.36] synonym: "phosphatidylinositol 4,5-bisphosphate phosphatase activity" BROAD [EC:3.1.3.36] synonym: "phosphatidylinositol-bisphosphatase activity" BROAD [EC:3.1.3.36] synonym: "PtdIns(4,5)P(2) phosphatase activity" EXACT [EC:3.1.3.36] synonym: "PtdIns(4,5)P2 phosphatase activity" EXACT [EC:3.1.3.36] synonym: "triphosphoinositide phosphatase activity" BROAD [EC:3.1.3.36] synonym: "triphosphoinositide phosphomonoesterase activity" BROAD [EC:3.1.3.36] xref: EC:3.1.3.36 xref: MetaCyc:PHOSPHATIDYLINOSITOL-BISPHOSPHATASE-RXN is_a: GO:0034593 ! phosphatidylinositol bisphosphate phosphatase activity is_a: GO:0034595 ! phosphoinositide 5-phosphatase activity [Term] id: GO:0004441 name: inositol-1,4-bisphosphate 1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 1D-myo-inositol 1,4-bisphosphate + H2O = 1D-myo-inositol 4-phosphate + phosphate." [EC:3.1.3.57, GOC:hb] synonym: "1D-myo-inositol-1,4-bisphosphate 1-phosphohydrolase activity" EXACT [EC:3.1.3.57] synonym: "inositol polyphosphate 1-phosphatase activity" BROAD [EC:3.1.3.57] synonym: "inositol-polyphosphate 1-phosphatase activity" EXACT [EC:3.1.3.57] xref: EC:3.1.3.57 xref: MetaCyc:3.1.3.57-RXN is_a: GO:0016312 ! inositol bisphosphate phosphatase activity [Term] id: GO:0004442 name: inositol-1,4,-bisphosphate 3-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 1,3-bisphosphate + H2O = D-myo-inositol 1-monophosphate + phosphate." [EC:3.1.3.65, GOC:go_curators] is_obsolete: true consider: GO:0004438 [Term] id: GO:0004443 name: inositol-1,4,-bisphosphate 4-phosphatase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: D-myo-inositol 3,4-bisphosphate + H2O = D-myo-inositol 3-monophosphate + phosphate." [EC:3.1.3.66, GOC:go_curators] is_obsolete: true consider: GO:0016316 [Term] id: GO:0004444 name: inositol-1,4,5-trisphosphate 1-phosphatase namespace: molecular_function def: "OBSOLETE. The removal of a phosphate group from the carbon-1 position of D-myo-inositol 1,4,5-trisphosphate." [EC:3.1.3.61, GOC:hb] comment: This term was made obsolete because the existence of this function has not been established. is_obsolete: true consider: GO:0046030 [Term] id: GO:0004445 name: inositol-polyphosphate 5-phosphatase activity namespace: molecular_function def: "Catalysis of the reactions: D-myo-inositol 1,4,5-trisphosphate + H2O = myo-inositol 1,4-bisphosphate + phosphate, and 1D-myo-inositol 1,3,4,5-tetrakisphosphate + H2O = 1D-myo-inositol 1,3,4-trisphosphate + phosphate." [EC:3.1.3.56] synonym: "1D-myo-inositol-1,4,5-trisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.56] synonym: "5PTase activity" RELATED [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-triphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol 1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "D-myo-inositol(1,4,5)/(1,3,4,5)-polyphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inosine triphosphatase activity" RELATED [EC:3.1.3.56] synonym: "inositol 1,4,5-trisphosphate phosphatase activity" BROAD [EC:3.1.3.56] synonym: "inositol phosphate 5-phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol polyphosphate-5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "inositol triphosphate 5-phosphomonoesterase activity" EXACT [] synonym: "inositol trisphosphate phosphomonoesterase activity" BROAD [EC:3.1.3.56] synonym: "inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [] synonym: "inositol-1,4,5-trisphosphate/1,3,4,5-tetrakisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P(3) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P3 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "Ins(1,4,5)P3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP(3)/Ins(1,3,4,5)P(4) 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "InsP3/Ins(1,3,4,5)P4 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "L-myo-inositol 1,4,5-trisphosphate-monoesterase activity" BROAD [EC:3.1.3.56] synonym: "myo-inositol-1,4,5-trisphosphate 5-phosphatase activity" EXACT [EC:3.1.3.56] synonym: "type I inositol-polyphosphate phosphatase activity" RELATED [EC:3.1.3.56] synonym: "type II inositol polyphosphate 5-phosphatase activity" RELATED [] synonym: "type II inositol-1,4,5-trisphosphate 5-phosphatase activity" NARROW [] xref: EC:3.1.3.56 xref: MetaCyc:3.1.3.56-RXN is_a: GO:0046030 ! inositol trisphosphate phosphatase activity [Term] id: GO:0004446 name: multiple inositol-polyphosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = myo-inositol pentakisphosphate (mixed isomers) + phosphate." [EC:3.1.3.62] synonym: "1D-myo-inositol-hexakisphosphate 5-phosphohydrolase activity" EXACT [EC:3.1.3.62] synonym: "inositol tetrakisphosphate phosphomonoesterase activity" EXACT [EC:3.1.3.62] synonym: "MIPP activity" EXACT [EC:3.1.3.62] xref: EC:3.1.3.62 xref: MetaCyc:RXN-7920 is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0004447 name: iodide peroxidase activity namespace: molecular_function def: "Catalysis of the reaction: iodide + H2O2 = iodine + 2 H2O." [EC:1.11.1.8] synonym: "iodide peroxidase-tyrosine iodinase activity" EXACT [EC:1.11.1.8] synonym: "iodide:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.8] synonym: "iodinase activity" RELATED [EC:1.11.1.8] synonym: "iodoperoxidase (heme type)" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodase activity" EXACT [EC:1.11.1.8] synonym: "iodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "monoiodotyrosine deiodinase activity" EXACT [EC:1.11.1.8] synonym: "thyroid peroxidase activity" RELATED [EC:1.11.1.8] synonym: "thyroperoxidase activity" RELATED [EC:1.11.1.8] synonym: "TPO activity" RELATED [EC:1.11.1.8] synonym: "tyrosine iodinase activity" EXACT [EC:1.11.1.8] xref: EC:1.11.1.8 xref: MetaCyc:IODIDE-PEROXIDASE-RXN is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004448 name: isocitrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + acceptor = 2-oxoglutarate + CO2 + reduced acceptor." [EC:1.1.1.41, EC:1.1.1.42] subset: gosubset_prok synonym: "beta-ketoglutaric-isocitric carboxylase activity" EXACT [EC:1.1.1.-] synonym: "IDH activity" EXACT [EC:1.1.1.-] synonym: "IDP activity" EXACT [EC:1.1.1.-] synonym: "IDP1" RELATED [EC:1.1.1.-] synonym: "IDP2" RELATED [EC:1.1.1.-] synonym: "IDP3" RELATED [EC:1.1.1.-] synonym: "isocitric acid dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "isocitric dehydrogenase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate carboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalosuccinate decarboxylase activity" EXACT [EC:1.1.1.-] synonym: "oxalsuccinic decarboxylase activity" EXACT [EC:1.1.1.-] xref: EC:1.1.1.- xref: MetaCyc:ISOCITDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004449 name: isocitrate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NAD+ = 2-oxoglutarate + CO2 + NADH + H+." [EC:1.1.1.41] subset: gosubset_prok synonym: "isocitrate dehydrogenase (NAD) activity" EXACT [EC:1.1.1.41] synonym: "isocitrate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.41] synonym: "NAD dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD isocitric dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "NAD-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] synonym: "nicotinamide adenine dinucleotide isocitrate dehydrogenase activity" EXACT [EC:1.1.1.41] xref: EC:1.1.1.41 xref: MetaCyc:ISOCITRATE-DEHYDROGENASE-NAD+-RXN xref: Reactome:11496 "isocitrate dehydrogenase (NAD+) activity" is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004450 name: isocitrate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH + H+." [EC:1.1.1.42] subset: gosubset_prok synonym: "dual-cofactor-specific isocitrate dehydrogenase activity" RELATED [EC:1.1.1.42] synonym: "isocitrate (NADP) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate dehydrogenase (NADP-dependent) activity" EXACT [EC:1.1.1.42] synonym: "isocitrate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.42] synonym: "NADP isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-ICDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-IDH activity" EXACT [EC:1.1.1.42] synonym: "NADP(+)-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-dependent isocitric dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-linked isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "NADP-specific isocitrate dehydrogenase activity" EXACT [EC:1.1.1.42] synonym: "triphosphopyridine nucleotide-linked isocitrate dehydrogenase- activity" RELATED [EC:1.1.1.42] xref: EC:1.1.1.42 xref: MetaCyc:ISOCITDEH-RXN xref: Reactome:11499 "isocitrate dehydrogenase (NADP+) activity" is_a: GO:0004448 ! isocitrate dehydrogenase activity [Term] id: GO:0004451 name: isocitrate lyase activity namespace: molecular_function def: "Catalysis of the reaction: isocitrate = succinate + glyoxylate." [EC:4.1.3.1] subset: gosubset_prok synonym: "ICL activity" EXACT [EC:4.1.3.1] synonym: "isocitrase activity" EXACT [EC:4.1.3.1] synonym: "isocitratase activity" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase (succinate-forming)" EXACT [EC:4.1.3.1] synonym: "isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] synonym: "isocitritase activity" EXACT [EC:4.1.3.1] synonym: "threo-DS-isocitrate glyoxylate-lyase activity" EXACT [EC:4.1.3.1] xref: EC:4.1.3.1 xref: MetaCyc:ISOCIT-CLEAV-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0004452 name: isopentenyl-diphosphate delta-isomerase activity namespace: molecular_function def: "Catalysis of the isomerization of isopentenyl diphosphate into dimethylallyl diphosphate." [EC:5.3.3.2] subset: gosubset_prok synonym: "IPP isomerase activity" EXACT [EC:5.3.3.2] synonym: "ipp isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenyl-diphosphate D-isomerase activity" EXACT [] synonym: "isopentenyl-diphosphate delta3-delta2-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate Delta-isomerase activity" EXACT [EC:5.3.3.2] synonym: "isopentenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] synonym: "methylbutenylpyrophosphate isomerase activity" EXACT [EC:5.3.3.2] xref: EC:5.3.3.2 xref: MetaCyc:IPPISOM-RXN xref: Reactome:11501 "isopentenyl-diphosphate delta-isomerase activity" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004453 name: juvenile-hormone esterase activity namespace: molecular_function def: "Catalysis of the reaction: methyl (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + H2O = (2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate + methanol. A carboxylesterase that hydrolyzes the ester linkage of juvenile hormone." [EC:3.1.1.59, EMBL:AF304352] synonym: "JH esterase activity" EXACT [EC:3.1.1.59] synonym: "JH-esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone analog esterase activity" EXACT [EC:3.1.1.59] synonym: "juvenile hormone carboxyesterase activity" EXACT [EC:3.1.1.59] synonym: "methyl-(2E,6E)-(10R,11S)-10,11-epoxy-3,7,11-trimethyltrideca-2,6-dienoate acylhydrolase activity" EXACT [EC:3.1.1.59] xref: EC:3.1.1.59 xref: MetaCyc:JUVENILE-HORMONE-ESTERASE-RXN is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004454 name: ketohexokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 1-phosphate." [EC:2.7.1.3] subset: gosubset_prok synonym: "ATP:D-fructose 1-phosphotransferase activity" EXACT [EC:2.7.1.3] synonym: "hepatic fructokinase activity" NARROW [EC:2.7.1.3] synonym: "ketohexokinase (phosphorylating)" EXACT [EC:2.7.1.3] xref: EC:2.7.1.3 xref: MetaCyc:KETOHEXOKINASE-RXN xref: Reactome:11506 "ketohexokinase activity" is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004455 name: ketol-acid reductoisomerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2,3-dihydroxy-3-methylbutanoate + NADP+ = (S)-2-hydroxy-2-methyl-3-oxobutanoate + NADPH + H+." [EC:1.1.1.86] subset: gosubset_prok synonym: "(R)-2,3-dihydroxy-3-methylbutanoate:NADP+ oxidoreductase (isomerizing)" EXACT [EC:1.1.1.86] synonym: "2-hydroxy-3-keto acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "acetohydroxy acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "acetolactate reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "alpha-keto-beta-hydroxylacyl reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate (isomerizing) dehydrogenase activity" EXACT [EC:1.1.1.86] synonym: "dihydroxyisovalerate dehydrogenase (isomerizing) activity" EXACT [EC:1.1.1.86] synonym: "isomeroreductase activity" EXACT [EC:1.1.1.86] synonym: "ketol acid reductoisomerase activity" EXACT [EC:1.1.1.86] synonym: "reductoisomerase activity" EXACT [EC:1.1.1.86] xref: EC:1.1.1.86 xref: MetaCyc:ACETOLACTREDUCTOISOM-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004456 name: phosphogluconate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate = 2-dehydro-3-deoxy-6-phospho-D-gluconate + H2O." [EC:4.2.1.12] subset: gosubset_prok synonym: "6-phospho-D-gluconate hydro-lyase (2-dehydro-3-deoxy-6-phospho-D-gluconate-forming)" EXACT [EC:4.2.1.12] synonym: "6-phospho-D-gluconate hydro-lyase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydrase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "6-phosphogluconic dehydrase activity" EXACT [EC:4.2.1.12] synonym: "gluconate 6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] synonym: "gluconate-6-phosphate dehydratase activity" EXACT [EC:4.2.1.12] xref: EC:4.2.1.12 xref: MetaCyc:PGLUCONDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004457 name: lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidation of lactate to produce pyruvate." [GOC:ai] subset: gosubset_prok is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0004458 name: D-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.4] subset: gosubset_prok synonym: "(R)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "cytochrome-dependent D-(-)-lactate dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-(-)-lactic cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate (cytochrome) dehydrogenase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.4] synonym: "D-lactate-cytochrome c reductase activity" EXACT [EC:1.1.2.4] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.4] xref: EC:1.1.2.4 xref: MetaCyc:D-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004459 name: L-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.27] subset: gosubset_prok synonym: "L-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.27] synonym: "L-lactic dehydrogenase activity" EXACT [EC:1.1.1.27] xref: EC:1.1.1.27 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-RXN xref: Reactome:11515 "L-lactate dehydrogenase activity" is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004460 name: L-lactate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactate + 2 ferricytochrome c = pyruvate + 2 ferrocytochrome c." [EC:1.1.2.3] subset: gosubset_prok synonym: "(S)-lactate:ferricytochrome-c 2-oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "cytochrome b2" RELATED [] synonym: "cytochrome b2 (flavin-free derivative of flavocytochrome b2)" RELATED [EC:1.1.2.3] synonym: "dehydrogenase, lactate (cytochrome)" EXACT [EC:1.1.2.3] synonym: "flavocytochrome b2" RELATED [EC:1.1.2.3] synonym: "L(+)-lactate:cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate cytochrome c reductase activity" EXACT [EC:1.1.2.3] synonym: "L-lactate ferricytochrome c oxidoreductase activity" EXACT [EC:1.1.2.3] synonym: "lactate dehydrogenase (cytochrome)" EXACT [EC:1.1.2.3] synonym: "lactic acid dehydrogenase activity" BROAD [EC:1.1.2.3] synonym: "lactic cytochrome c reductase activity" EXACT [EC:1.1.2.3] xref: EC:1.1.2.3 xref: MetaCyc:L-LACTATE-DEHYDROGENASE-CYTOCHROME-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016898 ! oxidoreductase activity, acting on the CH-OH group of donors, cytochrome as acceptor [Term] id: GO:0004461 name: lactose synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + D-glucose = UDP + lactose." [EC:2.4.1.22] synonym: "lactose synthetase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDP-galactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] synonym: "UDPgalactose:D-glucose 4-beta-D-galactotransferase activity" EXACT [EC:2.4.1.22] synonym: "uridine diphosphogalactose-glucose galactosyltransferase activity" EXACT [EC:2.4.1.22] xref: EC:2.4.1.22 xref: MetaCyc:LACTOSE-SYNTHASE-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0004462 name: lactoylglutathione lyase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal." [EC:4.4.1.5] subset: gosubset_prok synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing) activity" EXACT [EC:4.4.1.5] synonym: "(R)-S-lactoylglutathione methylglyoxal-lyase (isomerizing; glutathione-forming)" EXACT [EC:4.4.1.5] synonym: "aldoketomutase activity" EXACT [EC:4.4.1.5] synonym: "glyoxalase I activity" EXACT [EC:4.4.1.5] synonym: "glyoxylase I" RELATED [EC:4.4.1.5] synonym: "ketone-aldehyde mutase activity" EXACT [EC:4.4.1.5] synonym: "methylglyoxalase activity" EXACT [EC:4.4.1.5] xref: EC:4.4.1.5 xref: MetaCyc:GLYOXI-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004463 name: leukotriene-A4 hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate + H2O = (6Z,8E,10E,14Z)-(5S,12R)-5,12-dihydroxyicosa-6,8,10,14-tetraenoate." [EC:3.3.2.6] subset: gosubset_prok synonym: "(7E,9E,11Z,14Z)-(5S,6S)-5,6-epoxyicosa-7,9,11,14-tetraenoate hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A(4) hydrolase activity" EXACT [EC:3.3.2.6] synonym: "leukotriene A4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA-4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4 hydrolase activity" EXACT [EC:3.3.2.6] synonym: "LTA4H" RELATED [EC:3.3.2.6] xref: EC:3.3.2.6 xref: MetaCyc:LEUKOTRIENE-A4-HYDROLASE-RXN xref: Reactome:1463 "leukotriene-A4 hydrolase activity" is_a: GO:0016803 ! ether hydrolase activity [Term] id: GO:0004464 name: leukotriene-C4 synthase activity namespace: molecular_function def: "Catalysis of the reaction: leukotriene C4 = leukotriene A4 + glutathione." [EC:2.5.1.37] comment: Note that this function was EC:2.5.1.37. synonym: "(7E,9E,11Z,14Z)-(5S,6R)-5,6-epoxyicosa-7,9,11,14-tetraenoate:glutathione leukotriene-transferase (epoxide-ring-opening)" EXACT [EC:4.4.1.20] synonym: "(7E,9E,11Z,14Z)-(5S,6R)-6-(glutathion-S-yl)-5-hydroxyicosa-7,9,11,14-tetraenoate glutathione-lyase (epoxide-forming)" EXACT [EC:4.4.1.20] synonym: "leukotriene A(4):glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene A4:glutathione S-leukotrienyltransferase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene C4 synthetase activity" EXACT [EC:4.4.1.20] synonym: "leukotriene-C4 glutathione-lyase (leukotriene-A4-forming)" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC(4) synthetase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthase activity" EXACT [EC:4.4.1.20] synonym: "LTC4 synthetase activity" EXACT [EC:4.4.1.20] xref: EC:4.4.1.20 xref: MetaCyc:LEUKOTRIENE-C4-SYNTHASE-RXN xref: Reactome:11538 "leukotriene-C4 synthase activity" is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0004465 name: lipoprotein lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate." [EC:3.1.1.34] synonym: "clearing factor lipase activity" RELATED [EC:3.1.1.34] synonym: "diacylglycerol hydrolase activity" EXACT [EC:3.1.1.34] synonym: "diacylglycerol lipase activity" EXACT [EC:3.1.1.34] synonym: "diglyceride lipase activity" EXACT [EC:3.1.1.34] synonym: "lipemia-clearing factor" RELATED [EC:3.1.1.34] synonym: "postheparin esterase activity" EXACT [EC:3.1.1.34] synonym: "postheparin lipase activity" EXACT [EC:3.1.1.34] synonym: "triacylglycero-protein acylhydrolase activity" EXACT [EC:3.1.1.34] xref: EC:3.1.1.34 xref: MetaCyc:LIPOPROTEIN-LIPASE-RXN xref: Reactome:11541 "lipoprotein lipase activity" is_a: GO:0004091 ! carboxylesterase activity is_a: GO:0016298 ! lipase activity [Term] id: GO:0004466 name: long-chain-acyl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + ETF = 2,3-dehydroacyl-CoA + reduced ETF." [EC:1.3.99.13] subset: gosubset_prok synonym: "long-chain acyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:(acceptor) 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "long-chain-acyl-CoA:acceptor 2,3-oxidoreductase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-CoA dehydrogenase activity" EXACT [EC:1.3.99.13] synonym: "palmitoyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.13] xref: EC:1.3.99.13 xref: MetaCyc:LONG-CHAIN-ACYL-COA-DEHYDROGENASE-RXN is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0004467 name: long-chain fatty acid-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a long-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; long-chain fatty acids have chain lengths of C12-18." [EC:6.2.1.3] subset: gosubset_prok synonym: "ACS3" NARROW [EC:6.2.1.3] synonym: "acyl-activating enzyme activity" BROAD [EC:6.2.1.3] synonym: "acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "arachidonyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "FAA1" NARROW [EC:6.2.1.3] synonym: "fatty acid thiokinase (long chain) activity" EXACT [EC:6.2.1.3] synonym: "fatty acid thiokinase (long-chain) activity" EXACT [EC:6.2.1.3] synonym: "LCFA synthetase activity" EXACT [EC:6.2.1.3] synonym: "lignoceroyl-CoA synthase activity" EXACT [EC:6.2.1.3] synonym: "long chain fatty acyl-CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl CoA synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase activity" EXACT [] synonym: "long-chain acyl-CoA synthetase I" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-CoA synthetase II" NARROW [EC:6.2.1.3] synonym: "long-chain acyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain fatty acid activation" RELATED [] synonym: "long-chain fatty acid-CoA ligase activity" EXACT [] synonym: "long-chain fatty acyl coenzyme A synthetase activity" EXACT [EC:6.2.1.3] synonym: "long-chain-fatty-acid-CoA ligase activity" EXACT [] synonym: "long-chain-fatty-acyl-CoA synthetase activity" EXACT [] synonym: "oleoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl coenzyme A synthetase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA ligase" NARROW [EC:6.2.1.3] synonym: "palmitoyl-CoA synthase" NARROW [EC:6.2.1.3] synonym: "pristanoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "stearoyl-CoA synthetase" NARROW [EC:6.2.1.3] synonym: "thiokinase" RELATED [EC:6.2.1.3] xref: EC:6.2.1.3 xref: MetaCyc:ACYLCOASYN-RXN xref: MetaCyc:PWY-5143 xref: Reactome:11544 "long-chain-fatty-acid-CoA ligase activity" xref: UM-BBD_enzymeID:e0025 is_a: GO:0015645 ! fatty acid ligase activity [Term] id: GO:0004468 name: lysine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl phosphate + L-lysine = phosphate + N6-acetyl-L-lysine." [EC:2.3.1.32] subset: gosubset_prok synonym: "acetyl-phosphate:L-lysine 6-N-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "acetyl-phosphate:L-lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "LAT activity" EXACT [EC:2.3.1.32] synonym: "lysine acetyltransferase activity" EXACT [] synonym: "lysine N(6)-acetyltransferase activity" EXACT [EC:2.3.1.32] synonym: "lysine N6-acetyltransferase activity" EXACT [EC:2.3.1.32] xref: EC:2.3.1.32 xref: MetaCyc:LYSINE-N-ACETYLTRANSFERASE-RXN is_a: GO:0008080 ! N-acetyltransferase activity [Term] id: GO:0004470 name: malic enzyme activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyruvic-malic carboxylase activity" EXACT [EC:1.1.1.39] xref: MetaCyc:1.1.1.39-RXN xref: MetaCyc:MALIC-NAD-RXN xref: MetaCyc:MALIC-NADP-RXN is_a: GO:0016615 ! malate dehydrogenase activity [Term] id: GO:0004471 name: malate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH + H+. Does not decarboxylate oxaloacetate." [EC:1.1.1.39] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.39] synonym: "(S)-malate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.39] synonym: "NAD-malic enzyme activity" BROAD [EC:1.1.1.39] synonym: "NAD-specific malic enzyme" RELATED [EC:1.1.1.39] xref: EC:1.1.1.39 xref: MetaCyc:1.1.1.39-RXN is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004473 name: malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH + H+. Also decarboxylates oxaloacetate." [EC:1.1.1.40] subset: gosubset_prok synonym: "'malic' enzyme" RELATED [EC:1.1.1.40] synonym: "(S)-malate:NADP+ oxidoreductase (oxaloacetate-decarboxylating)" EXACT [EC:1.1.1.40] synonym: "L-malate:NADP oxidoreductase activity" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (decarboxylating, NADP)" EXACT [EC:1.1.1.40] synonym: "malate dehydrogenase (NADP, decarboxylating)" EXACT [EC:1.1.1.40] synonym: "NADP-linked decarboxylating malic enzyme" RELATED [EC:1.1.1.40] synonym: "NADP-malic enzyme activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malate dehydrogenase activity" EXACT [EC:1.1.1.40] synonym: "NADP-specific malic enzyme" RELATED [EC:1.1.1.40] xref: EC:1.1.1.40 xref: MetaCyc:MALIC-NADP-RXN is_a: GO:0004470 ! malic enzyme activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004474 name: malate synthase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + H2O + glyoxylate = L-malate + CoA." [EC:2.3.3.9] comment: Note that this function was formerly EC:4.1.3.2. subset: gosubset_prok synonym: "acetyl-CoA:glyoxylate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming)" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylate transacetylase activity" EXACT [EC:2.3.3.9] synonym: "glyoxylic transacetase activity" EXACT [EC:2.3.3.9] synonym: "L-malate glyoxylate-lyase (CoA-acetylating) activity" EXACT [EC:2.3.3.9] synonym: "malate condensing enzyme activity" RELATED [EC:2.3.3.9] synonym: "malate synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic synthetase activity" EXACT [EC:2.3.3.9] synonym: "malic-condensing enzyme activity" RELATED [EC:2.3.3.9] xref: EC:2.3.3.9 xref: MetaCyc:MALSYN-RXN is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0004475 name: mannose-1-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + alpha-D-mannose 1-phosphate = diphosphate + GDP-mannose." [EC:2.7.7.13] subset: gosubset_prok synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.13] synonym: "GTP-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "GTP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine 5'-diphospho-D-mannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine diphosphomannose pyrophosphorylase activity" EXACT [EC:2.7.7.13] synonym: "guanosine triphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.13] synonym: "mannose 1-phosphate guanylyltransferase (guanosine triphosphate)" EXACT [EC:2.7.7.13] synonym: "PIM-GMP (phosphomannose isomerase-guanosine 5'-diphospho-D-mannose pyrophosphorylase)" RELATED [EC:2.7.7.13] xref: EC:2.7.7.13 xref: MetaCyc:2.7.7.13-RXN is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0004476 name: mannose-6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate." [EC:5.3.1.8] subset: gosubset_prok synonym: "D-mannose-6-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.8] synonym: "D-mannose-6-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.8] synonym: "mannose phosphate isomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphohexoisomerase activity" BROAD [EC:5.3.1.8] synonym: "phosphohexomutase activity" BROAD [EC:5.3.1.8] synonym: "phosphomannoisomerase activity" EXACT [EC:5.3.1.8] synonym: "phosphomannose isomerase activity" EXACT [EC:5.3.1.8] xref: EC:5.3.1.8 xref: MetaCyc:MANNPISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004477 name: methenyltetrahydrofolate cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methenyltetrahydrofolate + H2O = 10-formyltetrahydrofolate." [EC:3.5.4.9] subset: gosubset_prok synonym: "5,10-methenyl-THF cyclohydrolase activity" EXACT [GOC:vw] synonym: "5,10-methenyltetrahydrofolate 5-hydrolase (decyclizing)" EXACT [EC:3.5.4.9] synonym: "citrovorum factor cyclodehydrase activity" EXACT [EC:3.5.4.9] synonym: "formyl-methenyl-methylenetetrahydrofolate synthetase (combined)" EXACT [EC:3.5.4.9] xref: EC:3.5.4.9 xref: MetaCyc:METHENYLTHFCYCLOHYDRO-RXN xref: Reactome:11565 "methenyltetrahydrofolate cyclohydrolase activity" is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004478 name: methionine adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + H2O = phosphate + diphosphate + S-adenosyl-L-methionine." [EC:2.5.1.6] subset: gosubset_prok synonym: "adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "AdoMet synthetase activity" EXACT [EC:2.5.1.6] synonym: "ATP-methionine adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "ATP:L-methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine S-adenosyltransferase activity" EXACT [EC:2.5.1.6] synonym: "methionine-activating enzyme" RELATED [EC:2.5.1.6] synonym: "S-adenosyl-L-methionine synthetase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthase activity" EXACT [EC:2.5.1.6] synonym: "S-adenosylmethionine synthetase activity" EXACT [EC:2.5.1.6] xref: EC:2.5.1.6 xref: MetaCyc:S-ADENMETSYN-RXN xref: Reactome:11567 "methionine adenosyltransferase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004479 name: methionyl-tRNA formyltransferase activity namespace: molecular_function alt_id: GO:0001718 alt_id: GO:0070128 def: "Catalysis of the reaction: 10-formyltetrahydrofolate + L-methionyl-tRNA + H2O = tetrahydrofolate + N-formylmethionyl-tRNA." [EC:2.1.2.9] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:L-methionyl-tRNA N-formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "conversion of met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "conversion of mitochondrial met-tRNAf to fmet-tRNA" RELATED [GO:curators] synonym: "formylmethionyl-transfer ribonucleic synthetase activity" EXACT [EC:2.1.2.9] synonym: "methionyl ribonucleic formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleate methyltransferase activity" RELATED [EC:2.1.2.9] synonym: "methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-transfer RNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA Met formyltransferase activity" EXACT [EC:2.1.2.9] synonym: "methionyl-tRNA transformylase activity" EXACT [EC:2.1.2.9] synonym: "mitochondrial N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N(10)-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] synonym: "N-terminal peptidyl-methionine N-formylation" RELATED [GO:curators] synonym: "N10-formyltetrahydrofolic-methionyl-transfer ribonucleic transformylase activity" EXACT [EC:2.1.2.9] xref: EC:2.1.2.9 xref: MetaCyc:METHIONYL-TRNA-FORMYLTRANSFERASE-RXN is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity relationship: part_of GO:0006413 ! translational initiation [Term] id: GO:0004481 name: methylene-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid methylene fatty acid." [EC:2.1.1.16] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.16] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (methenylating)" EXACT [EC:2.1.1.16] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.16] xref: EC:2.1.1.16 xref: MetaCyc:2.1.1.16-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004482 name: mRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppR-RNA; m7G(5')pppR-RNA is mRNA containing an N7-methylguanine cap; R may be guanosine or adenosine." [EC:2.1.1.56] synonym: "guanine-7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "messenger RNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.56] synonym: "S-adenosyl-L-methionine:mRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.56] xref: EC:2.1.1.56 xref: MetaCyc:MRNA-GUANINE-N7--METHYLTRANSFERASE-RXN xref: Reactome:72079 "mRNA (guanine-N7-)-methyltransferase activity" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004483 name: mRNA (nucleoside-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + m7G(5')pppR-RNA = S-adenosyl-L-homocysteine + m7G(5')pppRm-RNA. R may be guanosine or adenosine." [EC:2.1.1.57] subset: gosubset_prok synonym: "messenger ribonucleate nucleoside 2'-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "messenger RNA (nucleoside-2'-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "mRNA (adenosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] synonym: "S-adenosyl-L-methionine:mRNA (nucleoside-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.57] xref: EC:2.1.1.57 xref: MetaCyc:2.1.1.57-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008174 ! mRNA methyltransferase activity [Term] id: GO:0004484 name: mRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GTP + (5')pp-Pur-mRNA = diphosphate + G(5')ppp-Pur-mRNA; G(5')ppp-Pur-mRNA is mRNA containing a guanosine residue linked 5' through three phosphates to the 5' position of the terminal residue." [EC:2.7.7.50] synonym: "GTP--RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "GTP:mRNA guanylyltransferase activity" EXACT [] synonym: "messenger RNA guanylyltransferase activity" EXACT [EC:2.7.7.50] synonym: "mRNA capping enzyme activity" RELATED [EC:2.7.7.50] synonym: "protein lambda2" RELATED [EC:2.7.7.50] xref: EC:2.7.7.50 xref: MetaCyc:MRNA-GUANYLYLTRANSFERASE-RXN xref: Reactome:80327 "mRNA guanylyltransferase activity" is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0004485 name: methylcrotonoyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-methylcrotonyl-CoA + HCO3- = ADP + phosphate + 3-methylglutaconyl-CoA." [EC:6.4.1.4] subset: gosubset_prok synonym: "3-methylcrotonoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "beta-methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.4] synonym: "methylcrotonyl-CoA carboxylase activity" EXACT [EC:6.4.1.4] xref: EC:6.4.1.4 xref: MetaCyc:METHYLCROTONYL-COA-CARBOXYLASE-RXN xref: Reactome:11585 "methylcrotonoyl-CoA carboxylase activity" is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004486 name: methylenetetrahydrofolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD(P)+ = 5,10-methenyltetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.-, EC:1.5.1.15] subset: gosubset_prok synonym: "5,10-methylene-THF dehydrogenase activity" EXACT [GOC:vw] synonym: "N5,N10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.- xref: Reactome:11590 "methylenetetrahydrofolate dehydrogenase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004487 name: methylenetetrahydrofolate dehydrogenase (NAD+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NAD+ = 5,10-methenyltetrahydrofolate + NADH + H+." [EC:1.5.1.15] synonym: "5,10-methylenetetrahydrofolate dehydrogenase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NAD+ oxidoreductase" EXACT [EC:1.5.1.15] xref: EC:1.5.1.15 xref: MetaCyc:1.5.1.15-RXN is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity [Term] id: GO:0004488 name: methylenetetrahydrofolate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH + H+." [EC:1.5.1.5] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:NADP oxidoreductase activity" EXACT [EC:1.5.1.5] synonym: "5,10-methylenetetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.5] xref: EC:1.5.1.5 xref: MetaCyc:METHYLENETHFDEHYDROG-NADP-RXN is_a: GO:0004486 ! methylenetetrahydrofolate dehydrogenase activity [Term] id: GO:0004489 name: methylenetetrahydrofolate reductase (NADPH) activity namespace: molecular_function alt_id: GO:0008702 def: "Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+." [EC:1.5.1.20] comment: Includes EC 1.7.99.5. subset: gosubset_prok synonym: "1.7.99.5" RELATED [] synonym: "5,10-CH(2)-H(4)folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-CH2-H4folate reductase activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH(2)) activity" RELATED [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase (FADH) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (FADH2) activity" EXACT [] synonym: "5,10-methylenetetrahydrofolate reductase (NADPH) activity" EXACT [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "5,10-methylenetetrahydropteroylglutamate reductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:(acceptor) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NAD+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP(+) oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "5-methyltetrahydrofolate:NADP+ oxidoreductase activity" EXACT [EC:1.5.1.20] synonym: "MetF" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH(2)) activity" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase (NADPH2)" EXACT [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase [NAD(P)H]" RELATED [EC:1.5.1.20] synonym: "methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "methylenetetrahydrofolic acid reductase activity" BROAD [EC:1.5.1.20] synonym: "MTHFR activity" BROAD [EC:1.5.1.20] synonym: "N(5),N(10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N(5,10)-methylenetetrahydrofolate reductase activity" BROAD [EC:1.5.1.20] synonym: "N5,10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] synonym: "N5,N10-methylenetetrahydrofolate reductase activity" EXACT [EC:1.5.1.20] xref: EC:1.5.1.20 xref: MetaCyc:1.5.1.20-RXN xref: Reactome:11594 "methylenetetrahydrofolate reductase (NADPH) activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004490 name: methylglutaconyl-CoA hydratase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxy-3-methylglutaryl-CoA = trans-3-methylglutaconyl-CoA + H2O." [EC:4.2.1.18] subset: gosubset_prok synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase (trans-3-methylglutaconyl-CoA-forming)" EXACT [EC:4.2.1.18] synonym: "(S)-3-hydroxy-3-methylglutaryl-CoA hydro-lyase activity" EXACT [EC:4.2.1.18] synonym: "3-methylglutaconyl CoA hydratase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconase activity" EXACT [EC:4.2.1.18] synonym: "methylglutaconyl coenzyme A hydratase activity" EXACT [EC:4.2.1.18] xref: EC:4.2.1.18 xref: MetaCyc:METHYLGLUTACONYL-COA-HYDRATASE-RXN xref: Reactome:11601 "methylglutaconyl-CoA hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004491 name: methylmalonate-semialdehyde dehydrogenase (acylating) activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+." [EC:1.2.1.27] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoate:NAD+ 3-oxidoreductase (CoA-propanoylating)" EXACT [EC:1.2.1.27] synonym: "MMSA dehydrogenase activity" EXACT [EC:1.2.1.27] synonym: "MSDH activity" EXACT [EC:1.2.1.27] xref: EC:1.2.1.27 xref: MetaCyc:1.2.1.27-RXN xref: Reactome:70889 "methylmalonate-semialdehyde dehydrogenase (acylating) activity" is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004492 name: methylmalonyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-2-methyl-3-oxopropanoyl-CoA = propanoyl-CoA + CO2." [EC:4.1.1.41] subset: gosubset_prok synonym: "(S)-2-methyl-3-oxopropanoyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase (propanoyl-CoA-forming)" EXACT [EC:4.1.1.41] synonym: "(S)-methylmalonyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.41] synonym: "methylmalonyl-coenzyme A decarboxylase activity" EXACT [EC:4.1.1.41] xref: EC:4.1.1.41 xref: MetaCyc:METHYLMALONYL-COA-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004493 name: methylmalonyl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = (S)-2-methyl-3-oxopropanoyl-CoA." [EC:5.1.99.1] subset: gosubset_prok synonym: "2-methyl-3-oxopropanoyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "DL-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "dl-methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl coenzyme A racemase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.1] synonym: "methylmalonyl-CoA racemase activity" EXACT [EC:5.1.99.1] xref: EC:5.1.99.1 xref: MetaCyc:METHYLMALONYL-COA-EPIM-RXN xref: Reactome:11610 "methylmalonyl-CoA epimerase activity" is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0004494 name: methylmalonyl-CoA mutase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-2-methyl-3-oxopropanoyl-CoA = succinyl-CoA." [EC:5.4.99.2] subset: gosubset_prok synonym: "(R)-2-methyl-3-oxopropanoyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(R)-methylmalonyl-CoA CoA-carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "(S)-methylmalonyl-CoA mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A carbonylmutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl coenzyme A mutase activity" EXACT [EC:5.4.99.2] synonym: "methylmalonyl-CoA CoA-carbonyl mutase activity" EXACT [EC:5.4.99.2] xref: EC:5.4.99.2 xref: MetaCyc:METHYLMALONYL-COA-MUT-RXN xref: Reactome:11612 "methylmalonyl-CoA mutase activity" xref: UM-BBD_enzymeID:e0575 is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0004495 name: mevaldate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-mevalonate + acceptor = mevaldate + reduced acceptor." [EC:1.1.1.32, EC:1.1.1.33] xref: EC:1.1.1.- xref: MetaCyc:MEVALDATE-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004496 name: mevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-mevalonate = ADP + (R)-5-phosphomevalonate." [EC:2.7.1.36] subset: gosubset_prok synonym: "ATP:(R)-mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "ATP:mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate 5-phosphotransferase activity" EXACT [EC:2.7.1.36] synonym: "mevalonate kinase (phosphorylating)" EXACT [EC:2.7.1.36] synonym: "mevalonate phosphokinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic acid kinase activity" EXACT [EC:2.7.1.36] synonym: "mevalonic kinase activity" EXACT [EC:2.7.1.36] synonym: "MVA kinase activity" EXACT [EC:2.7.1.36] xref: EC:2.7.1.36 xref: MetaCyc:MEVALONATE-KINASE-RXN xref: Reactome:11620 "mevalonate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004497 name: monooxygenase activity namespace: molecular_function def: "Catalysis of the incorporation of one atom from molecular oxygen into a compound and the reduction of the other atom of oxygen to water." [http://www.onelook.com/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "hydroxylase activity" RELATED [GOC:mah, GOC:vk] xref: Reactome:9021 "monooxygenase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004498 name: calcidiol 1-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: calcidiol + NADPH + H+ + O2 = calcitriol + NADP+ + H2O." [EC:1.14.13.13] synonym: "1-hydroxylase-25-hydroxyvitamin D3" RELATED [EC:1.14.13.13] synonym: "25-hydroxy D3-1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxy vitamin D3 1-alpha-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-hydroxylase activity" EXACT [] synonym: "25-hydroxycholecalciferol 1-monooxygenase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxycholecalciferol-1-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D-1 alpha hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-hydroxyvitamin D3 1alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "25-OHD-1 alpha-hydroxylase activity" EXACT [EC:1.14.13.13] synonym: "calcidiol,NADPH:oxygen oxidoreductase (1-hydroxylating)" EXACT [EC:1.14.13.13] synonym: "cytochrome P450 CYP27B" NARROW [] xref: EC:1.14.13.13 xref: MetaCyc:CALCIDIOL-1-MONOOXYGENASE-RXN xref: Reactome:11623 "calcidiol 1-monooxygenase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004499 name: flavin-containing monooxygenase activity namespace: molecular_function alt_id: GO:0047076 def: "Catalysis of the reaction: N,N-dimethylaniline + NADPH + H+ + O2 = N,N-dimethylaniline N-oxide + NADP+ + H2O." [EC:1.14.13.8] subset: gosubset_prok synonym: "1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine:oxygen N-oxidoreductase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline monooxygenase (N-oxide-forming) activity" EXACT [] synonym: "dimethylaniline N-oxidase activity" EXACT [EC:1.13.12.11] synonym: "dimethylaniline oxidase activity" EXACT [EC:1.13.12.11] synonym: "DMA oxidase activity" EXACT [EC:1.13.12.11] synonym: "FAD-containing monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "flavin mixed function oxidase activity" RELATED [EC:1.13.12.11] synonym: "flavin monooxygenase activity" RELATED [EC:1.13.12.11] synonym: "FMO activity" RELATED [EC:1.13.12.11] synonym: "FMO-I" RELATED [EC:1.13.12.11] synonym: "FMO-II" RELATED [EC:1.13.12.11] synonym: "FMO1" RELATED [EC:1.13.12.11] synonym: "FMO2" RELATED [EC:1.13.12.11] synonym: "FMO3" RELATED [EC:1.13.12.11] synonym: "FMO4" RELATED [EC:1.13.12.11] synonym: "FMO5" RELATED [EC:1.13.12.11] synonym: "methylphenyltetrahydropyridine N-monooxygenase activity" EXACT [] synonym: "mixed-function amine oxidase activity" RELATED [EC:1.13.12.11] synonym: "N,N-dimethylaniline monooxygenase activity" EXACT [EC:1.13.12.11] synonym: "N,N-dimethylaniline,NADPH:oxygen oxidoreductase (N-oxide-forming)" EXACT [EC:1.13.12.11] synonym: "Ziegler's enzyme" RELATED [EC:1.13.12.11] xref: EC:1.14.13.8 xref: MetaCyc:1.14.13.8-RXN xref: Reactome:11625 "flavin-containing monooxygenase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004500 name: dopamine beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenethylamine + ascorbate + O2 = noradrenaline + dehydroascorbate + H2O." [EC:1.14.17.1] subset: gosubset_prok synonym: "(3,4-dihydroxyphenethylamine)beta-mono-oxygenase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "3,4-dihydroxyphenethylamine,ascorbate:oxygen oxidoreductase (beta-hydroxylating)" EXACT [EC:1.14.17.1] synonym: "4-(2-aminoethyl)pyrocatechol beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopa beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine b-hydroxylase activity" EXACT [] synonym: "dopamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine beta-oxidase activity" EXACT [EC:1.14.17.1] synonym: "dopamine hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "dopamine-B-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "MDBH (membrane-associated dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] synonym: "oxygenase, dopamine beta-mono-" EXACT [EC:1.14.17.1] synonym: "phenylamine beta-hydroxylase activity" EXACT [EC:1.14.17.1] synonym: "SDBH (soluble dopamine beta-monooxygenase)" RELATED [EC:1.14.17.1] xref: EC:1.14.17.1 xref: MetaCyc:DOPAMINE-BETA-MONOOXYGENASE-RXN xref: Reactome:12238 "dopamine beta-monooxygenase activity" is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004501 name: ecdysone 20-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: ecdysone + donor-H2 + O2 = 20-hydroxyecdysone + acceptor + H2O." [EC:1.14.99.22] synonym: "alpha-ecdysone C-20 hydroxylase activity" EXACT [EC:1.14.99.22] synonym: "ecdysone 20-hydroxylase activity" EXACT [] synonym: "ecdysone modification" BROAD [] synonym: "ecdysone,hydrogen-donor:oxygen oxidoreductase (20-hydroxylating)" EXACT [EC:1.14.99.22] xref: EC:1.14.99.22 xref: MetaCyc:ECDYSONE-20-MONOOXYGENASE-RXN is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004502 name: kynurenine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-kynurenine + NADPH + H+ + O2 = 3-hydroxy-L-kynurenine + NADP+ + H2O." [EC:1.14.13.9] subset: gosubset_prok synonym: "kynurenine 3-hydroxylase activity" EXACT [] synonym: "kynurenine hydroxylase activity" EXACT [EC:1.14.13.9] synonym: "L-kynurenine,NADPH:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.13.9] synonym: "L-kynurenine-3-hydroxylase activity" EXACT [EC:1.14.13.9] xref: EC:1.14.13.9 xref: MetaCyc:KYNURENINE-3-MONOOXYGENASE-RXN xref: Reactome:12242 "kynurenine 3-monooxygenase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004503 name: monophenol monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + L-DOPA + O2 = L-DOPA + DOPAquinone + H2O." [EC:1.14.18.1] subset: gosubset_prok synonym: "catecholase" BROAD [EC:1.14.18.1] synonym: "chlorogenic acid oxidase activity" EXACT [EC:1.14.18.1] synonym: "chlorogenic oxidase activity" EXACT [EC:1.14.18.1] synonym: "cresolase activity" EXACT [EC:1.14.18.1] synonym: "dopa oxidase" BROAD [EC:1.14.18.1] synonym: "monophenol dihydroxyphenylalanine:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol monooxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "monophenol oxygenase" EXACT [PMID:2494997] synonym: "monophenol, dihydroxy-L-phenylalanine oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenol,L-dopa:oxygen oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "monophenolase activity" EXACT [EC:1.14.18.1] synonym: "N-acetyl-6-hydroxytryptophan oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol oxidoreductase" BROAD [EC:1.14.18.1] synonym: "o-diphenol:O2 oxidoreductase activity" EXACT [EC:1.14.18.1] synonym: "o-diphenol:oxygen oxidoreductase" BROAD [EC:1.14.18.1] synonym: "phenol oxidase activity" EXACT [] synonym: "phenolase activity" BROAD [EC:1.14.18.1] synonym: "polyaromatic oxidase activity" EXACT [EC:1.14.18.1] synonym: "polyphenolase activity" EXACT [EC:1.14.18.1] synonym: "prophenol oxidase" RELATED [] synonym: "pyrocatechol oxidase" BROAD [EC:1.14.18.1] synonym: "tyrosinase activity" BROAD [EC:1.14.18.1] synonym: "tyrosine-dopa oxidase activity" EXACT [EC:1.14.18.1] xref: EC:1.14.18.1 xref: MetaCyc:MONOPHENOL-MONOOXYGENASE-RXN is_a: GO:0016716 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, another compound as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004504 name: peptidylglycine monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptidyl-glycine + ascorbate + O2 = peptidyl(2-hydroxyglycine) + dehydroascorbate + H2O." [EC:1.14.17.3] subset: gosubset_prok synonym: "PAM activity" EXACT [EC:1.14.17.3] synonym: "PAM-A" RELATED [EC:1.14.17.3] synonym: "PAM-B" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amidating enzyme" RELATED [EC:1.14.17.3] synonym: "peptide alpha-amide synthase activity" EXACT [EC:1.14.17.3] synonym: "peptide-alpha-amide synthetase activity" EXACT [EC:1.14.17.3] synonym: "peptidyl alpha-amidating enzyme activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine 2-hydroxylase activity" EXACT [] synonym: "peptidylglycine alpha-amidating monooxygenase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine alpha-hydroxylase activity" EXACT [EC:1.14.17.3] synonym: "peptidylglycine,ascorbate:oxygen oxidoreductase (2-hydroxylating)" EXACT [EC:1.14.17.3] synonym: "synthase, peptide alpha-amide" EXACT [EC:1.14.17.3] xref: EC:1.14.17.3 xref: MetaCyc:PEPTIDYLGLYCINE-MONOOXYGENASE-RXN is_a: GO:0016715 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004505 name: phenylalanine 4-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-phenylalanine + tetrahydrobiopterin + O2 = L-tyrosine + 4-alpha-hydroxytetrahydrobiopterin." [EC:1.14.16.1] subset: gosubset_prok synonym: "L-phenylalanine,tetrahydrobiopterin:oxygen oxidoreductase (4-hydroxylating)" EXACT [EC:1.14.16.1] synonym: "PAH activity" EXACT [EC:1.14.16.1] synonym: "phenylalaninase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine 4-hydroxylase activity" EXACT [EC:1.14.16.1] synonym: "phenylalanine hydroxylase activity" EXACT [] xref: EC:1.14.16.1 xref: MetaCyc:PHENYLALANINE-4-MONOOXYGENASE-RXN xref: Reactome:12249 "phenylalanine 4-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004506 name: squalene monooxygenase activity namespace: molecular_function def: "Catalysis of the formation of a 2,3-epoxide in squalene." [EC:1.14.99.7] synonym: "squalene 2,3-oxidocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene hydroxylase activity" EXACT [] synonym: "squalene oxydocyclase activity" EXACT [EC:1.14.99.7] synonym: "squalene,hydrogen-donor:oxygen oxidoreductase (2,3-epoxidizing)" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxidase activity" EXACT [EC:1.14.99.7] synonym: "squalene-2,3-epoxide cyclase activity" EXACT [EC:1.14.99.7] xref: EC:1.14.99.7 xref: MetaCyc:SQUALENE-MONOOXYGENASE-RXN xref: Reactome:12251 "squalene monooxygenase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004507 name: steroid 11-beta-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.4] synonym: "cytochrome P450 CYP11B1" NARROW [] synonym: "cytochrome P450 CYP11B2" NARROW [] synonym: "cytochrome p450 XIB1 activity" NARROW [EC:1.14.15.4] synonym: "oxygenase, steroid 11beta -mono-" EXACT [EC:1.14.15.4] synonym: "steroid 11-beta-hydroxylase activity" EXACT [] synonym: "steroid 11-beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta-monooxygenase activity" EXACT [EC:1.14.15.4] synonym: "steroid 11beta/18-hydroxylase activity" EXACT [EC:1.14.15.4] synonym: "steroid,reduced-adrenal-ferredoxin:oxygen oxidoreductase (11beta-hydroxylating)" EXACT [EC:1.14.15.4] xref: EC:1.14.15.4 xref: MetaCyc:STEROID-11-BETA-MONOOXYGENASE-RXN xref: Reactome:12257 "steroid 11-beta-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004508 name: steroid 17-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + AH2 + O2 = a 17a-hydroxysteroid + A + H2O." [EC:1.14.99.9] synonym: "17alpha-hydroxylase-C17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "cytochrome P-450 (P-45017alpha,lyase)" RELATED [EC:1.14.99.9] synonym: "cytochrome P450 CYP17" NARROW [] synonym: "cytochrome p450 XVIIA1 activity" NARROW [EC:1.14.99.9] synonym: "cytochrome P45017alpha" RELATED [EC:1.14.99.9] synonym: "steroid 17-alpha-hydroxylase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase-C17-20 lyase activity" EXACT [] synonym: "steroid 17-alpha-hydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-hydroxylase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alpha-monooxygenase activity" EXACT [EC:1.14.99.9] synonym: "steroid 17alphahydroxylase/17,20 lyase activity" EXACT [EC:1.14.99.9] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (17alpha-hydroxylating)" EXACT [EC:1.14.99.9] xref: EC:1.14.99.9 xref: MetaCyc:STEROID-17-ALPHA-MONOOXYGENASE-RXN xref: Reactome:12260 "steroid 17-alpha-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004509 name: steroid 21-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = a 21-hydroxysteroid + acceptor + H2O." [EC:1.14.99.10] synonym: "21-hydroxylase activity" EXACT [EC:1.14.99.10] synonym: "cytochrome P450 CYP21A1" NARROW [] synonym: "cytochrome p450 XXIA1 activity" NARROW [EC:1.14.99.10] synonym: "steroid 21-hydroxylase activity" EXACT [] synonym: "steroid,hydrogen-donor:oxygen oxidoreductase (21-hydroxylating)" EXACT [EC:1.14.99.10] xref: EC:1.14.99.10 xref: MetaCyc:STEROID-21-MONOOXYGENASE-RXN xref: Reactome:12262 "steroid 21-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004510 name: tryptophan 5-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + tetrahydrobiopterin + O2 = 5-hydroxy-L-tryptophan + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.4] synonym: "indoleacetic acid-5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "L-tryptophan hydroxylase activity" EXACT [] synonym: "L-tryptophan,tetrahydrobiopterin:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.16.4] synonym: "tryptophan 5-hydroxylase activity" EXACT [EC:1.14.16.4] synonym: "tryptophan hydroxylase activity" EXACT [EC:1.14.16.4] xref: EC:1.14.16.4 xref: MetaCyc:TRYPTOPHAN-5-MONOOXYGENASE-RXN xref: Reactome:12281 "tryptophan 5-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004511 name: tyrosine 3-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + tetrahydrobiopterin + O2 = 3,4-dihydroxy-L-phenylalanine + 4-alpha-hydroxytetrahydrobiopterin + H2O." [EC:1.14.16.2] synonym: "L-tyrosine hydroxylase activity" EXACT [EC:1.14.16.2] synonym: "L-tyrosine,tetrahydrobiopterin:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.16.2] synonym: "tyrosine 3-hydroxylase activity" EXACT [] synonym: "tyrosine hydroxylase activity" EXACT [] xref: EC:1.14.16.2 xref: MetaCyc:TYROSINE-3-MONOOXYGENASE-RXN xref: Reactome:12282 "tyrosine 3-monooxygenase activity" is_a: GO:0016714 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced pteridine as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004512 name: inositol-3-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 6-phosphate = 1D-myo-inositol 3-phosphate; requires NAD, which dehydrogenates the CHOH group to CO at C-5 of the glucose 6-phosphate, making C-6 into an active methylene, able to condense with the aldehyde at C-1. Finally, the enzyme-bound NADH reconverts C-5 into the CHOH form." [EC:5.5.1.4] subset: gosubset_prok synonym: "1L-myo-inositol-1-phosphate lyase (isomerizing)" EXACT [EC:5.5.1.4] synonym: "D-glucose 6-phosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucocycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "glucose 6-phosphate cyclase activity" EXACT [EC:5.5.1.4] synonym: "glucose-6-phosphate inositol monophosphate cycloaldolase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthatase activity" EXACT [EC:5.5.1.4] synonym: "inositol 1-phosphate synthetase activity" EXACT [EC:5.5.1.4] synonym: "myo-inositol-1-phosphate synthase activity" EXACT [] xref: EC:5.5.1.4 xref: MetaCyc:MYO-INOSITOL-1-PHOSPHATE-SYNTHASE-RXN is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0004513 name: neolactotetraosylceramide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-D-glucosylceramide." [EC:2.4.99.10] synonym: "CMP-N-acetylneuraminate:neolactotetraosylceramide alpha-2,3-sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "cytidine monophosphoacetylneuraminate-neolactotetraosylceramide sialyltransferase activity" EXACT [EC:2.4.99.10] synonym: "SAT-3" RELATED [EC:2.4.99.10] synonym: "sialyltransferase 3" RELATED [EC:2.4.99.10] xref: EC:2.4.99.10 xref: MetaCyc:2.4.99.10-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0004514 name: nicotinate-nucleotide diphosphorylase (carboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate + CO2 = pyridine-2,3-dicarboxylate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.19] subset: gosubset_prok synonym: "NAD pyrophosphorylase activity" EXACT [EC:2.4.2.19] synonym: "nicotinate mononucleotide pyrophosphorylase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "nicotinate-nucleotide pyrophosphorylase (carboxylating) activity" EXACT [] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase (carboxylating)" EXACT [EC:2.4.2.19] synonym: "QAPRTase activity" EXACT [EC:2.4.2.19] synonym: "quinolinate phosphoribosyltransferase (decarboxylating) activity" EXACT [EC:2.4.2.19] synonym: "quinolinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] synonym: "quinolinic phosphoribosyltransferase activity" EXACT [EC:2.4.2.19] xref: EC:2.4.2.19 xref: MetaCyc:QUINOPRIBOTRANS-RXN xref: Reactome:12286 "nicotinate-nucleotide diphosphorylase (carboxylating) activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004515 name: nicotinate-nucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nicotinate ribonucleotide = diphosphate + deamido-NAD+." [EC:2.7.7.18] subset: gosubset_prok synonym: "ATP:nicotinate-nucleotide adenylyltransferase activity" EXACT [] synonym: "ATP:nicotinate-ribonucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) diphosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD(+) pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamido-NAD+ pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "deamidonicotinamide adenine dinucleotide pyrophosphorylase activity" EXACT [EC:2.7.7.18] synonym: "NaMN-ATase activity" EXACT [EC:2.7.7.18] synonym: "nicotinate mononucleotide adenylyltransferase activity" EXACT [EC:2.7.7.18] synonym: "nicotinic acid mononucleotide adenylyltransferase" NARROW [] xref: EC:2.7.7.18 xref: MetaCyc:NICONUCADENYLYLTRAN-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004516 name: nicotinate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinate D-ribonucleotide + diphosphate = nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.11] subset: gosubset_prok synonym: "niacin ribonucleotidase activity" EXACT [EC:2.4.2.11] synonym: "nicotinate-nucleotide:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide glycohydrolase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid mononucleotide pyrophosphorylase activity" EXACT [EC:2.4.2.11] synonym: "nicotinic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.11] xref: EC:2.4.2.11 xref: MetaCyc:NICOTINATEPRIBOSYLTRANS-RXN xref: Reactome:12293 "nicotinate phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004517 name: nitric-oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine + n NADPH + n H+ + m O2 = citrulline + nitric oxide + n NADP+." [EC:1.14.13.39] subset: gosubset_prok synonym: "endothelium-derived relaxation factor-forming enzyme activity" RELATED [EC:1.14.13.39] synonym: "endothelium-derived relaxing factor synthase activity" RELATED [EC:1.14.13.39] synonym: "L-arginine,NADPH:oxygen oxidoreductase (nitric-oxide-forming) activity" EXACT [EC:1.14.13.39] synonym: "NADPH-diaphorase activity" EXACT [EC:1.14.13.39] synonym: "nitric oxide synthase activity" EXACT [] synonym: "nitric oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "nitric-oxide synthetase activity" EXACT [EC:1.14.13.39] synonym: "NO synthase activity" EXACT [EC:1.14.13.39] xref: EC:1.14.13.39 xref: MetaCyc:NITRIC-OXIDE-SYNTHASE-RXN xref: Reactome:12296 "nitric-oxide synthase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0004518 name: nuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids." [ISBN:0198547684] comment: Note that 'tRNA nucleotidyltransferase activity ; GO:0009022', also known as 'ribonuclease PH', does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: EC:3.1.-.- is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0004519 name: endonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:3138 "endonuclease activity" is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004520 name: endodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "DNA nicking activity" RELATED [GOC:mah] synonym: "endonuclease G activity" NARROW [] xref: Reactome:3136 "endodeoxyribonuclease activity" is_a: GO:0004519 ! endonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004521 name: endoribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within ribonucleic acid by creating internal breaks." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "endonuclease G activity" NARROW [] is_a: GO:0004519 ! endonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004522 name: pancreatic ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA to 3'-phosphomononucleotides and 3'-phosphooligonucleotides ending in C-P or U-P with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.5] synonym: "alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "ceratitis capitata alkaline ribonuclease activity" EXACT [EC:3.1.27.5] synonym: "endoribonuclease I" RELATED [EC:3.1.27.5] synonym: "gene S glycoproteins" RELATED [EC:3.1.27.5] synonym: "gene S locus-specific glycoproteins" RELATED [EC:3.1.27.5] synonym: "pancreatic RNase activity" EXACT [EC:3.1.27.5] synonym: "ribonuclease A" EXACT [] synonym: "ribonuclease I activity" EXACT [EC:3.1.27.5] synonym: "ribonucleate 3'-pyrimidino-oligonucleotidohydrolase activity" EXACT [EC:3.1.27.5] synonym: "ribonucleic phosphatase activity" EXACT [EC:3.1.27.5] synonym: "RNase A activity" EXACT [EC:3.1.27.5] synonym: "RNase activity" BROAD [EC:3.1.27.5] synonym: "RNase I activity" EXACT [EC:3.1.27.5] synonym: "S-genotype-assocd. glycoproteins" RELATED [EC:3.1.27.5] synonym: "SLSG glycoproteins" RELATED [EC:3.1.27.5] xref: EC:3.1.27.5 xref: MetaCyc:3.1.27.5-RXN xref: Wikipedia:Ribonuclease_A is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004523 name: ribonuclease H activity namespace: molecular_function alt_id: GO:0004524 def: "Catalysis of the endonucleolytic cleavage of RNA in RNA-DNA hybrids to 5'-phosphomonoesters." [EC:3.1.26.4] comment: Note that the EC recommended name for this enzyme activity is 'calf thymus ribonuclease H', even though it is found in many species. subset: gosubset_prok synonym: "calf thymus ribonuclease H activity" EXACT [] synonym: "endoribonuclease H" RELATED [EC:3.1.26.4] synonym: "endoribonuclease H (calf thymus)" RELATED [EC:3.1.26.4] synonym: "endoribonuclease0 H activity" NARROW [EC:3.1.26.4] synonym: "hybrid nuclease activity" EXACT [EC:3.1.26.4] synonym: "hybrid ribonuclease activity" EXACT [EC:3.1.26.4] synonym: "hybridase (ribonuclease H)" EXACT [EC:3.1.26.4] synonym: "hybridase activity" EXACT [EC:3.1.26.4] synonym: "ribonuclease H1 activity" NARROW [] synonym: "ribonuclease H2 activity" NARROW [] synonym: "ribonuclease H3 activity" NARROW [] synonym: "RNA*DNA hybrid ribonucleotidohydrolase activity" EXACT [EC:3.1.26.4] synonym: "RNase H activity" EXACT [] synonym: "RNase H1 activity" NARROW [] synonym: "RNase H2 activity" NARROW [] synonym: "RNase H3 activity" NARROW [] xref: EC:3.1.26.4 xref: MetaCyc:3.1.26.4-RXN xref: Reactome:12321 "ribonuclease H activity" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004525 name: ribonuclease III activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA with 5'-phosphomonoesters and 3'-OH termini; makes two staggered cuts in both strands of dsRNA, leaving a 3' overhang of 2 nt." [PMID:11157775, PMID:15242644] subset: gosubset_prok synonym: "pre-mRNA 3'-end processing endonuclease" NARROW [] synonym: "ribonuclease 3 activity" EXACT [EC:3.1.26.3] synonym: "RNase III activity" EXACT [EC:3.1.26.3] xref: EC:3.1.26.3 xref: MetaCyc:3.1.26.3-RXN xref: Reactome:12326 "ribonuclease III activity" is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004526 name: ribonuclease P activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of RNA, removing 5' extra nucleotides from tRNA precursor." [EC:3.1.26.5] subset: gosubset_prok synonym: "RNase P" EXACT [] synonym: "tRNA 5' leader endonuclease activity" EXACT [] xref: EC:3.1.26.5 xref: MetaCyc:3.1.26.5-RXN xref: Wikipedia:RNase_P is_a: GO:0004549 ! tRNA-specific ribonuclease activity is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004527 name: exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004528 name: phosphodiesterase I activity namespace: molecular_function def: "Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides." [EC:3.1.4.1] subset: gosubset_prok synonym: "5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "5'-exonuclease activity" RELATED [EC:3.1.4.1] synonym: "5'-NPDase activity" RELATED [EC:3.1.4.1] synonym: "5'-nucleotide phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDase activity" RELATED [EC:3.1.4.1] synonym: "5'-PDE activity" RELATED [EC:3.1.4.1] synonym: "5'-phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "5'NPDE activity" RELATED [EC:3.1.4.1] synonym: "alkaline phosphodiesterase activity" RELATED [EC:3.1.4.1] synonym: "exonuclease I activity" RELATED [EC:3.1.4.1] synonym: "nucleotide pyrophosphatase/phosphodiesterase I activity" EXACT [EC:3.1.4.1] synonym: "oligonucleate 5'-nucleotidohydrolase activity" EXACT [EC:3.1.4.1] synonym: "orthophosphoric diester phosphohydrolase activity" EXACT [EC:3.1.4.1] synonym: "PDE I activity" EXACT [EC:3.1.4.1] synonym: "phosphodiesterase activity" BROAD [EC:3.1.4.1] xref: EC:3.1.4.1 xref: MetaCyc:3.1.4.1-RXN is_a: GO:0004527 ! exonuclease activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004529 name: exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004530 name: deoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 5'-phosphodinucleotide and 5'-phosphooligonucleotide end products." [EC:3.1.21.1] subset: gosubset_prok synonym: "alkaline deoxyribonuclease activity" EXACT [EC:3.1.21.1] synonym: "alkaline DNase activity" EXACT [EC:3.1.21.1] synonym: "deoxyribonuclease (pancreatic)" NARROW [EC:3.1.21.1] synonym: "deoxyribonuclease A" RELATED [EC:3.1.21.1] synonym: "deoxyribonucleic phosphatase activity" EXACT [EC:3.1.21.1] synonym: "DNA depolymerase activity" EXACT [EC:3.1.21.1] synonym: "DNA endonuclease activity" EXACT [EC:3.1.21.1] synonym: "DNA nuclease activity" EXACT [EC:3.1.21.1] synonym: "DNAase activity" EXACT [EC:3.1.21.1] synonym: "DNase activity" NARROW [EC:3.1.21.1] synonym: "DNase I" RELATED [EC:3.1.21.1] synonym: "dornava" RELATED [EC:3.1.21.1] synonym: "dornavac" RELATED [EC:3.1.21.1] synonym: "endodeoxyribonuclease I" RELATED [EC:3.1.21.1] synonym: "Escherichia coli endonuclease I" RELATED [EC:3.1.21.1] synonym: "pancreatic deoxyribonuclease" NARROW [EC:3.1.21.1] synonym: "pancreatic DNase activity" NARROW [EC:3.1.21.1] synonym: "pancreatic dornase" NARROW [EC:3.1.21.1] synonym: "thymonuclease activity" NARROW [EC:3.1.21.1] synonym: "thymonuclease, dornase activity" EXACT [EC:3.1.21.1] xref: EC:3.1.21.1 xref: MetaCyc:3.1.21.1-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004531 name: deoxyribonuclease II activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to 3'-phosphodinucleotide and 3'-phosphooligonucleotide end products." [EC:3.1.22.1] subset: gosubset_prok synonym: "acid deoxyribonuclease activity" EXACT [EC:3.1.22.1] synonym: "acid DNase activity" EXACT [EC:3.1.22.1] synonym: "deoxyribonucleate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.22.1] synonym: "DNase II activity" EXACT [EC:3.1.22.1] synonym: "lysosomal DNase II activity" NARROW [EC:3.1.22.1] synonym: "pancreatic DNase II" RELATED [EC:3.1.22.1] xref: EC:3.1.22.1 xref: MetaCyc:3.1.22.1-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0004532 name: exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] subset: gosubset_prok xref: Reactome:3228 "exoribonuclease activity" is_a: GO:0004527 ! exonuclease activity is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004533 name: exoribonuclease H activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of RNA to 5'-phosphomonoester oligonucleotides in both 5' to 3' and 3' to 5' directions." [EC:3.1.13.2, ISBN:0198547684] synonym: "retroviral reverse transcriptase RNaseH" RELATED [EC:3.1.13.2] xref: EC:3.1.13.2 xref: MetaCyc:3.1.13.2-RXN is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004534 name: 5'-3' exoribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' terminus of an RNA molecule." [GOC:mah, ISBN:0198547684] xref: EC:3.1.13.- xref: Reactome:12364 "5'-3' exoribonuclease activity" is_a: GO:0008409 ! 5'-3' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0004535 name: poly(A)-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of poly(A) to 5'-AMP." [EC:3.1.13.4, ISBN:0198547684] synonym: "2',3'-exoribonuclease activity" RELATED [EC:3.1.13.4] synonym: "3'-exoribonuclease activity" EXACT [EC:3.1.13.4] synonym: "poly(A)-specific RNase activity" EXACT [] xref: EC:3.1.13.4 xref: MetaCyc:3.1.13.4-RXN xref: Reactome:12368 "poly(A)-specific ribonuclease activity" is_a: GO:0000175 ! 3'-5'-exoribonuclease activity [Term] id: GO:0004536 name: deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004537 name: caspase-activated deoxyribonuclease activity namespace: molecular_function xref: Reactome:12372 "caspase-activated deoxyribonuclease activity" is_a: GO:0004536 ! deoxyribonuclease activity [Term] id: GO:0004540 name: ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:mah, ISBN:0198547684] subset: gosubset_prok is_a: GO:0004518 ! nuclease activity [Term] id: GO:0004549 name: tRNA-specific ribonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of phosphodiester bonds in tRNA molecules." [GOC:mah] subset: gosubset_prok synonym: "tRNA-specific RNase activity" EXACT [] is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0004550 name: nucleoside diphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + nucleoside diphosphate = ADP + nucleoside triphosphate." [EC:2.7.4.6] subset: gosubset_prok synonym: "ATP:nucleoside-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "NDK activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside 5'-diphosphate phosphotransferase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphate (UDP) kinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside diphosphokinase activity" EXACT [EC:2.7.4.6] synonym: "nucleoside-diphosphate kinase activity" EXACT [] synonym: "nucleotide phosphate kinase activity" EXACT [EC:2.7.4.6] synonym: "UDP kinase activity" EXACT [EC:2.7.4.6] synonym: "uridine diphosphate kinase activity" EXACT [EC:2.7.4.6] xref: EC:2.7.4.6 xref: MetaCyc:NUCLEOSIDE-DIP-KIN-RXN xref: Reactome:12403 "nucleoside diphosphate kinase activity" is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019205 ! nucleobase, nucleoside, nucleotide kinase activity relationship: part_of GO:0006165 ! nucleoside diphosphate phosphorylation [Term] id: GO:0004551 name: nucleotide diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a dinucleotide + H2O = 2 mononucleotides." [EC:3.6.1.9] subset: gosubset_prok synonym: "dinucleotide nucleotidohydrolase activity" EXACT [EC:3.6.1.9] synonym: "nucleotide pyrophosphatase activity" EXACT [] synonym: "nucleotide-sugar pyrophosphatase activity" EXACT [EC:3.6.1.9] xref: EC:3.6.1.9 xref: MetaCyc:NUCLEOTIDE-PYROPHOSPHATASE-RXN xref: Reactome:12405 "nucleotide diphosphatase activity" is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004552 name: octanol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 1-octanol + NAD+ = 1-octanal + NADH + H+." [EC:1.1.1.73] synonym: "1-octanol dehydrogenase activity" EXACT [EC:1.1.1.73] synonym: "octanol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.73] xref: EC:1.1.1.73 xref: MetaCyc:OCTANOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004553 name: hydrolase activity, hydrolyzing O-glycosyl compounds namespace: molecular_function alt_id: GO:0016800 def: "Catalysis of the hydrolysis of any O-glycosyl bond." [GOC:mah] subset: gosubset_prok synonym: "O-glucosyl hydrolase activity" EXACT [] xref: EC:3.2.1 is_a: GO:0016798 ! hydrolase activity, acting on glycosyl bonds [Term] id: GO:0004555 name: alpha,alpha-trehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose + H2O = 2 D-glucose." [EC:3.2.1.28] subset: gosubset_prok synonym: "alpha,alpha-trehalose glucohydrolase activity" EXACT [EC:3.2.1.28] xref: EC:3.2.1.28 xref: MetaCyc:TREHALA-RXN xref: Reactome:12414 "alpha,alpha-trehalase activity" is_a: GO:0015927 ! trehalase activity [Term] id: GO:0004556 name: alpha-amylase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-alpha-D-glucosidic linkages in polysaccharides containing three or more 1,4-alpha-linked D-glucose units." [EC:3.2.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan glucanohydrolase activity" EXACT [EC:3.2.1.1] synonym: "alpha amylase activity" EXACT [EC:3.2.1.1] synonym: "endoamylase activity" EXACT [EC:3.2.1.1] synonym: "glycogenase activity" BROAD [EC:3.2.1.1] synonym: "taka-amylase A" RELATED [EC:3.2.1.1] xref: EC:3.2.1.1 xref: MetaCyc:ALPHA-AMYL-RXN xref: MetaCyc:RXN-1823 xref: MetaCyc:RXN-1825 xref: Reactome:12418 "alpha-amylase activity" is_a: GO:0016160 ! amylase activity [Term] id: GO:0004557 name: alpha-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-galactose residues in alpha-D-galactosides, including galactose oligosaccharides, galactomannans and galactohydrolase." [EC:3.2.1.22] subset: gosubset_prok synonym: "alpha-D-galactosidase activity" EXACT [EC:3.2.1.22] synonym: "alpha-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "alpha-galactosidase A" RELATED [EC:3.2.1.22] synonym: "alpha-galactoside galactohydrolase activity" EXACT [EC:3.2.1.22] synonym: "melibiase activity" EXACT [] xref: EC:3.2.1.22 xref: MetaCyc:ALPHAGALACTOSID-RXN is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004558 name: alpha-glucosidase activity namespace: molecular_function alt_id: GO:0004562 alt_id: GO:0016982 def: "Catalysis of the hydrolysis of terminal, non-reducing 1,4-linked alpha-D-glucose residues with release of alpha-D-glucose." [EC:3.2.1.20] subset: gosubset_prok synonym: "acid maltase activity" EXACT [EC:3.2.1.20] synonym: "alpha-1,4-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucopyranosidase activity" EXACT [EC:3.2.1.20] synonym: "alpha-glucosidase II" RELATED [] synonym: "alpha-glucoside hydrolase activity" EXACT [EC:3.2.1.20] synonym: "glucoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidoinvertase activity" EXACT [EC:3.2.1.20] synonym: "glucosidosucrase activity" EXACT [EC:3.2.1.20] synonym: "lysosomal alpha-glucosidase activity" BROAD [EC:3.2.1.20] synonym: "maltase-glucoamylase activity" EXACT [EC:3.2.1.20] xref: EC:3.2.1.20 xref: MetaCyc:MALTODEXGLUCOSID-RXN xref: Reactome:12426 "alpha-glucosidase activity" is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004559 name: alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing alpha-D-mannose residues in alpha-D-mannosides." [EC:3.2.1.24] subset: gosubset_prok synonym: "1,2-alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.24] synonym: "alpha-D-mannopyranosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "alpha-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.24] synonym: "exo-alpha-mannosidase activity" EXACT [EC:3.2.1.24] synonym: "p-nitrophenyl-alpha-mannosidase activity" EXACT [EC:3.2.1.24] xref: EC:3.2.1.24 xref: MetaCyc:3.2.1.24-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004560 name: alpha-L-fucosidase activity namespace: molecular_function def: "Catalysis of the reaction: an alpha-L-fucoside + H2O = an alcohol + L-fucose." [EC:3.2.1.51] subset: gosubset_prok synonym: "alpha-fucosidase activity" EXACT [EC:3.2.1.51] synonym: "alpha-L-fucoside fucohydrolase activity" EXACT [EC:3.2.1.51] xref: EC:3.2.1.51 xref: MetaCyc:ALPHA-L-FUCOSIDASE-RXN is_a: GO:0015928 ! fucosidase activity [Term] id: GO:0004561 name: alpha-N-acetylglucosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-glucosamine residues in N-acetyl-alpha-D-glucosaminides." [EC:3.2.1.50] synonym: "alpha-acetylglucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-D-2-acetamido-2-deoxyglucosidase activity" EXACT [EC:3.2.1.50] synonym: "alpha-N-acetyl-D-glucosaminide N-acetylglucosaminohydrolase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-D-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "N-acetyl-alpha-glucosaminidase activity" EXACT [EC:3.2.1.50] synonym: "NAG activity" EXACT [EC:3.2.1.50] xref: EC:3.2.1.50 xref: MetaCyc:3.2.1.50-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004563 name: beta-N-acetylhexosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-hexosamine residues in N-acetyl-beta-D-hexosaminides." [EC:3.2.1.52] subset: gosubset_prok synonym: "beta-acetylaminodeoxyhexosidase activity" EXACT [EC:3.2.1.52] synonym: "beta-acetylhexosaminidinase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-D-N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "beta-N-acetyl-D-hexosaminide N-acetylhexosaminohydrolase activity" EXACT [EC:3.2.1.52] synonym: "hexosaminidase A" RELATED [EC:3.2.1.52] synonym: "N-acetyl-beta-D-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-glucosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetyl-beta-hexosaminidase activity" EXACT [EC:3.2.1.52] synonym: "N-acetylhexosaminidase activity" EXACT [EC:3.2.1.52] xref: EC:3.2.1.52 xref: MetaCyc:3.2.1.52-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0004564 name: beta-fructofuranosidase activity namespace: molecular_function def: "Catalysis of the reaction: a fructofuranosylated fructofuranosyl acceptor + H2O = a non fructofuranosylated fructofuranosyl acceptor + a beta-D-fructofuranoside." [EC:3.2.1.26, MetaCyc:RXN-9985] subset: gosubset_prok synonym: "acid invertase activity" EXACT [] synonym: "alkaline invertase activity" EXACT [] synonym: "beta-D-fructofuranoside fructohydrolase activity" EXACT [] synonym: "beta-fructosidase activity" BROAD [] synonym: "beta-h-fructosidase activity" EXACT [] synonym: "fructosylinvertase activity" EXACT [] synonym: "glucosucrase activity" EXACT [] synonym: "invertase activity" BROAD [] synonym: "invertin activity" BROAD [] synonym: "maxinvert L 1000 activity" EXACT [] synonym: "saccharase activity" EXACT [] synonym: "sucrase activity" BROAD [] xref: EC:3.2.1.26 xref: MetaCyc:RXN-9985 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004565 name: beta-galactosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23] comment: Note that the inclusion of 'MetaCyc:BGALACT-PWY' is exceptional: normally MetaCyc pathway entries are database references for biological process terms, not molecular function terms. An exception was made in this case because the MetaCyc entry 'BGALACT-PWY' describes only one reaction, that catalyzed by beta-galactosidase. subset: gosubset_prok synonym: "beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-galactoside galactohydrolase activity" EXACT [EC:3.2.1.23] synonym: "beta-D-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "beta-lactosidase activity" EXACT [EC:3.2.1.23] synonym: "exo-(1->4)-beta-D-galactanase activity" EXACT [EC:3.2.1.23] synonym: "hydrolact" RELATED [EC:3.2.1.23] synonym: "lactose hydrolysis" RELATED [] synonym: "lactozym" RELATED [EC:3.2.1.23] synonym: "maxilact" RELATED [EC:3.2.1.23] synonym: "oryzatym" RELATED [EC:3.2.1.23] synonym: "S 2107" RELATED [EC:3.2.1.23] synonym: "sumiklat" RELATED [EC:3.2.1.23] synonym: "trilactase activity" EXACT [EC:3.2.1.23] xref: EC:3.2.1.23 xref: MetaCyc:3.2.1.23-RXN xref: MetaCyc:BGALACT-PWY is_a: GO:0015925 ! galactosidase activity [Term] id: GO:0004566 name: beta-glucuronidase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-D-glucuronoside + H2O = an alcohol + D-glucuronate." [EC:3.2.1.31] subset: gosubset_prok synonym: "beta-D-glucuronoside glucuronosohydrolase activity" EXACT [EC:3.2.1.31] synonym: "beta-glucuronide glucuronohydrolase activity" EXACT [EC:3.2.1.31] synonym: "exo-beta-D-glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "glucuronidase activity" EXACT [EC:3.2.1.31] synonym: "ketodase activity" EXACT [EC:3.2.1.31] xref: EC:3.2.1.31 xref: MetaCyc:BETA-GLUCURONID-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004567 name: beta-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-mannose residues in beta-D-mannosides." [EC:3.2.1.25] subset: gosubset_prok synonym: "beta-D-mannosidase activity" EXACT [EC:3.2.1.25] synonym: "beta-D-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "beta-mannoside mannohydrolase activity" EXACT [EC:3.2.1.25] synonym: "exo-beta-D-mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannanase activity" EXACT [EC:3.2.1.25] synonym: "mannase activity" EXACT [EC:3.2.1.25] xref: EC:3.2.1.25 xref: MetaCyc:3.2.1.25-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0004568 name: chitinase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of N-acetyl-beta-D-glucosaminide 1,4-beta-linkages in chitin and chitodextrins." [EC:3.2.1.14] subset: gosubset_prok synonym: "1,4-beta-poly-N-acetylglucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "beta-1,4-poly-N-acetyl glucosamidinase activity" EXACT [EC:3.2.1.14] synonym: "chitodextrinase activity" EXACT [EC:3.2.1.14] synonym: "poly-beta-glucosaminidase activity" EXACT [EC:3.2.1.14] synonym: "poly[1,4-(N-acetyl-beta-D-glucosaminide)] glycanohydrolase activity" EXACT [EC:3.2.1.14] xref: EC:3.2.1.14 xref: MetaCyc:3.2.1.14-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004569 name: glycoprotein endo-alpha-1,2-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal alpha-glucosyl-(1,3)-mannosyl unit from Glc-Man(9)-(GlcNAc)(2) oligosaccharide component of the glycoprotein produced in the Golgi membrane." [EC:3.2.1.130] synonym: "endo-alpha-mannosidase activity" EXACT [EC:3.2.1.130] synonym: "endomannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosyl mannosidase activity" EXACT [EC:3.2.1.130] synonym: "glucosylmannosidase activity" EXACT [EC:3.2.1.130] synonym: "glycoprotein glucosylmannohydrolase activity" EXACT [EC:3.2.1.130] xref: EC:3.2.1.130 xref: MetaCyc:3.2.1.130-RXN is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0004571 name: mannosyl-oligosaccharide 1,2-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,2-linked alpha-D-mannose residues in the oligo-mannose oligosaccharide Man(9)(GlcNAc)(2)." [EC:3.2.1.113] subset: gosubset_prok synonym: "1,2-alpha-mannosidase" BROAD [EC:3.2.1.113] synonym: "1,2-alpha-mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.113] synonym: "exo-alpha-1,2-mannanase activity" EXACT [EC:3.2.1.113] synonym: "glycoprotein processing mannosidase I" RELATED [EC:3.2.1.113] synonym: "man9-mannosidase activity" RELATED [EC:3.2.1.113] synonym: "Man9-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "ManI activity" NARROW [EC:3.2.1.113] synonym: "mannose-9 processing alpha-mannosidase activity" EXACT [EC:3.2.1.113] synonym: "mannosidase 1A activity" NARROW [EC:3.2.1.113] synonym: "mannosidase 1B activity" NARROW [EC:3.2.1.113] synonym: "mannosidase I" RELATED [EC:3.2.1.113] xref: EC:3.2.1.113 xref: MetaCyc:3.2.1.113-RXN is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004572 name: mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the terminal 1,3- and 1,6-linked alpha-D-mannose residues in the mannosyl-oligosaccharide Man(5)(GlcNAc)(3)." [EC:3.2.1.114] synonym: "1,3-(1,6-)mannosyl-oligosaccharide alpha-D-mannohydrolase activity" EXACT [EC:3.2.1.114] synonym: "alpha-D-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "alpha1-3,6-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "exo-1,3-1,6-alpha-mannosidase activity" EXACT [EC:3.2.1.114] synonym: "GlcNAc transferase I-dependent alpha1,3[alpha1,6]mannosidase activity" EXACT [EC:3.2.1.114] synonym: "Golgi alpha-mannosidase II" RELATED [EC:3.2.1.114] synonym: "ManII activity" NARROW [EC:3.2.1.114] synonym: "mannosidase II activity" NARROW [EC:3.2.1.114] xref: EC:3.2.1.114 xref: MetaCyc:3.2.1.114-RXN is_a: GO:0015924 ! mannosyl-oligosaccharide mannosidase activity [Term] id: GO:0004573 name: mannosyl-oligosaccharide glucosidase activity namespace: molecular_function def: "Catalysis of the exohydrolysis of the non-reducing terminal glucose residue in the mannosyl-oligosaccharide Glc(3)Man(9)GlcNAc(2)." [EC:3.2.1.106] synonym: "Glc3Man9NAc2 oligosaccharide glucosidase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucohydrolase activity" EXACT [EC:3.2.1.106] synonym: "mannosyl-oligosaccharide glucosidase (processing A-glucosidase I) activity" EXACT [] synonym: "processing A-glucosidase I activity" RELATED [EC:3.2.1.106] synonym: "trimming glucosidase I" RELATED [EC:3.2.1.106] xref: EC:3.2.1.106 xref: MetaCyc:3.2.1.106-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004574 name: oligo-1,6-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,6-alpha-D-glucosidic linkages in some oligosaccharides produced from starch and glycogen by alpha-amylase, and in isomaltose." [EC:3.2.1.10] subset: gosubset_prok synonym: "alpha-limit dextrinase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "dextrin 6alpha-glucanohydrolase activity" EXACT [EC:3.2.1.10] synonym: "exo-oligo-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "isomaltase activity" RELATED [EC:3.2.1.10] synonym: "limit dextrinase (erroneous)" BROAD [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucohydrolase activity" EXACT [EC:3.2.1.10] synonym: "oligosaccharide alpha-1,6-glucosidase activity" EXACT [EC:3.2.1.10] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.10] xref: EC:3.2.1.10 xref: MetaCyc:3.2.1.10-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0004575 name: sucrose alpha-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + H2O = alpha-D-glucose + beta-D-fructose." [EC:3.2.1.48, MetaCyc:RXN-1461] synonym: "alpha-D-glucopyranosyl beta-D-fructofuranoside hydrolysis" EXACT [] synonym: "beta-D-fructofuranosyl alpha-D-glucopyranoside hydrolysis" EXACT [] synonym: "intestinal sucrase activity" NARROW [EC:3.2.1.48] synonym: "invertase activity" BROAD [] synonym: "sucrase activity" EXACT [EC:3.2.1.48] synonym: "sucrase(invertase)" RELATED [EC:3.2.1.48] synonym: "sucrase-isomaltase activity" RELATED [EC:3.2.1.48] synonym: "sucrose alpha-D-glucohydrolase activity" EXACT [] synonym: "sucrose alpha-glucohydrolase activity" EXACT [EC:3.2.1.48] synonym: "sucrose hydrolysis" EXACT [] synonym: "sucrose-alpha-D-glucohydrolase activity" EXACT [EC:3.2.1.48] xref: EC:3.2.1.26 xref: EC:3.2.1.48 xref: KEGG:R00802 xref: MetaCyc:RXN-1461 xref: Reactome:12493 "sucrose alpha-glucosidase activity" is_a: GO:0004558 ! alpha-glucosidase activity is_a: GO:0004564 ! beta-fructofuranosidase activity [Term] id: GO:0004576 name: oligosaccharyl transferase activity namespace: molecular_function def: "Catalysis of the transfer of a oligosaccharyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok synonym: "oligosaccharide transferase activity" EXACT [EC:2.4.1.119, GOC:mah] xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004577 name: N-acetylglucosaminyldiphosphodolichol N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + N-acetyl-D-glucosaminyl-diphosphodolichol = UDP + N,N''-diacetylchitobiosyldiphosphodolichol." [EC:2.4.1.141] synonym: "N,N'-diacetylchitobiosylpyrophosphoryldolichol synthase activity" EXACT [EC:2.4.1.141] synonym: "UDP-GlcNAc:dolichyl-pyrophosphoryl-GlcNAc GlcNAc transferase activity" EXACT [EC:2.4.1.141] synonym: "UDP-N-acetyl-D-glucosamine:N-acetyl-D-glucosaminyl-diphosphodolichol N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.141] synonym: "uridine diphosphoacetylglucosamine-dolichylacetylglucosamine pyrophosphate acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.141] xref: EC:2.4.1.141 xref: MetaCyc:2.4.1.141-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0004578 name: chitobiosyldiphosphodolichol beta-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + chitobiosyldiphosphodolichol = GDP + beta-D-mannosylchitobiosyldiphosphodolichol." [EC:2.4.1.142] synonym: "GDP-mannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "GDP-mannose:chitobiosyldiphosphodolichol beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.142] synonym: "guanosine diphosphomannose-dolichol diphosphochitobiose mannosyltransferase activity" EXACT [EC:2.4.1.142] xref: EC:2.4.1.142 xref: MetaCyc:2.4.1.142-RXN is_a: GO:0019187 ! beta-1,4-mannosyltransferase activity [Term] id: GO:0004579 name: dolichyl-diphosphooligosaccharide-protein glycotransferase activity namespace: molecular_function def: "Catalysis of the reaction: dolichyl diphosphooligosaccharide + protein L-asparagine = dolichyl diphosphate + a glycoprotein with the oligosaccharide chain attached by glycosylamine linkage to protein L-asparagine." [EC:2.4.1.119] synonym: "asparagine N-glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyl-diphosphooligosaccharide-protein glycosyltransferase activity" EXACT [] synonym: "dolichyl-diphosphooligosaccharide:protein-L-asparagine oligopolysaccharidotransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphooligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichyldiphosphoryloligosaccharide-protein oligosaccharyltransferase activity" EXACT [EC:2.4.1.119] synonym: "dolichylpyrophosphodiacetylchitobiose-protein glycosyltransferase activity" EXACT [EC:2.4.1.119] synonym: "oligomannosyltransferase activity" RELATED [EC:2.4.1.119] xref: EC:2.4.1.119 xref: MetaCyc:2.4.1.119-RXN is_a: GO:0004576 ! oligosaccharyl transferase activity [Term] id: GO:0004581 name: dolichyl-phosphate beta-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + dolichyl phosphate = UDP + dolichyl beta-D-glucosyl phosphate." [EC:2.4.1.117] subset: gosubset_prok synonym: "polyprenyl phosphate:UDP-D-glucose glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose dolichyl-phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichol phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolicholphosphoryl glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl monophosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl phosphate glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDP-glucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "UDPglucose:dolichyl-phosphate beta-D-glucosyltransferase activity" EXACT [EC:2.4.1.117] synonym: "uridine diphosphoglucose-dolichol glucosyltransferase activity" EXACT [EC:2.4.1.117] xref: EC:2.4.1.117 xref: MetaCyc:2.4.1.117-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0004582 name: dolichyl-phosphate beta-D-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose + dolichyl phosphate = GDP + dolichyl D-mannosyl phosphate." [EC:2.4.1.83] subset: gosubset_prok synonym: "dolichol phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichol-phosphate-mannose synthase activity" EXACT [] synonym: "dolichyl mannosyl phosphate synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phosphate mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "dolichyl-phospho-mannose synthase activity" EXACT [EC:2.4.1.83] synonym: "DPM synthase activity" EXACT [] synonym: "GDP-mannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDP-mannose:dolichyl-phosphate beta-D-mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPMan:DolP mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose-dolichylmonophosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "GDPmannose:dolichyl-phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "guanosine diphosphomannose-dolichol phosphate mannosyltransferase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphodolichol synthase activity" EXACT [EC:2.4.1.83] synonym: "mannosylphosphoryldolichol synthase activity" EXACT [EC:2.4.1.83] xref: EC:2.4.1.83 xref: MetaCyc:2.4.1.83-RXN xref: Reactome:12521 "dolichyl-phosphate beta-D-mannosyltransferase activity" is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004583 name: dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-glucosyl residue from dolichyl-phosphate D-glucose into a membrane lipid-linked oligosaccharide." [GOC:mah] xref: EC:2.4.1.- xref: MetaCyc:RXN-5472 is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0004584 name: dolichyl-phosphate-mannose-glycolipid alpha-mannosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an alpha-D-mannosyl residue from dolichyl-phosphate D-mannose into membrane lipid-linked oligosaccharide." [EC:2.4.1.130] synonym: "dolichol phosphomannose-oligosaccharide-lipid mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "dolichyl-phosphate-D-mannose:glycolipid alpha-D-mannosyltransferase activity" EXACT [EC:2.4.1.130] synonym: "oligomannosylsynthase activity" EXACT [EC:2.4.1.130] xref: EC:2.4.1.130 xref: MetaCyc:2.4.1.130-RXN is_a: GO:0000030 ! mannosyltransferase activity [Term] id: GO:0004585 name: ornithine carbamoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: carbamoyl phosphate + L-ornithine = phosphate + L-citrulline." [EC:2.1.3.3] subset: gosubset_prok synonym: "carbamoyl-phosphate:L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "carbamylphosphate-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "citrulline phosphorylase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamoyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "L-ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "ornithine carbamyltransferase activity" EXACT [EC:2.1.3.3] synonym: "ornithine transcarbamylase activity" EXACT [EC:2.1.3.3] synonym: "OTC activity" EXACT [EC:2.1.3.3] synonym: "OTCase activity" EXACT [EC:2.1.3.3] xref: EC:2.1.3.3 xref: MetaCyc:ORNCARBAMTRANSFER-RXN xref: Reactome:12530 "ornithine carbamoyltransferase activity" is_a: GO:0016743 ! carboxyl- or carbamoyltransferase activity relationship: part_of GO:0006591 ! ornithine metabolic process [Term] id: GO:0004586 name: ornithine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = putrescine + CO2." [EC:4.1.1.17] subset: gosubset_prok synonym: "L-ornithine carboxy-lyase (putrescine-forming)" EXACT [EC:4.1.1.17] synonym: "L-ornithine carboxy-lyase activity" NARROW [EC:4.1.1.17] synonym: "SpeC" RELATED [EC:4.1.1.17] xref: EC:4.1.1.17 xref: MetaCyc:ORNDECARBOX-RXN xref: Reactome:12531 "ornithine decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004587 name: ornithine-oxo-acid transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine + a 2-oxo acid = L-glutamate 5-semialdehyde + an L-amino acid." [EC:2.6.1.13] subset: gosubset_prok synonym: "GabT" RELATED [EC:2.6.1.13] synonym: "L-ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:2-oxo-acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "L-ornithine:alpha-ketoglutarate delta-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "OAT" RELATED [EC:2.6.1.13] synonym: "ornithine 5-aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine delta-transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine ketoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--2-oxoacid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--alpha-ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--keto acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--ketoglutarate aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo acid aminotransferase activity" EXACT [EC:2.6.1.13] synonym: "ornithine--oxo-acid transaminase activity" EXACT [EC:2.6.1.13] synonym: "ornithine-oxo-acid aminotransferase activity" EXACT [] synonym: "ornithine:alpha-oxoglutarate transaminase activity" EXACT [EC:2.6.1.13] xref: EC:2.6.1.13 xref: MetaCyc:ORNITHINE--OXO-ACID-AMINOTRANSFERASE-RXN xref: Reactome:12532 "ornithine-oxo-acid transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004588 name: orotate phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate + diphosphate = orotate + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.10] subset: gosubset_prok synonym: "OPRT activity" EXACT [EC:2.4.2.10] synonym: "OPRTase activity" EXACT [EC:2.4.2.10] synonym: "orotate phosphoribosyl pyrophosphate transferase activity" EXACT [EC:2.4.2.10] synonym: "orotic acid phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine 5'-monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate diphosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidine-5'-phosphate:diphosphate phospho-alpha-D-ribosyl-transferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate phosphoribosyltransferase activity" EXACT [EC:2.4.2.10] synonym: "orotidylate pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic acid pyrophosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic phosphorylase activity" EXACT [EC:2.4.2.10] synonym: "orotidylic pyrophosphorylase activity" EXACT [EC:2.4.2.10] xref: EC:2.4.2.10 xref: MetaCyc:OROPRIBTRANS-RXN xref: Reactome:12534 "orotate phosphoribosyltransferase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004589 name: orotate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-dihydroorotate + NAD+ = orotate + NADH + H+." [EC:1.3.1.14] synonym: "(S)-dihydroorotate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.14] xref: EC:1.3.1.14 xref: MetaCyc:OROTATE-REDUCTASE-NADH-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004590 name: orotidine-5'-phosphate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: orotidine 5'-phosphate = UMP + CO2." [EC:4.1.1.23] subset: gosubset_prok synonym: "ODCase activity" EXACT [EC:4.1.1.23] synonym: "OMP decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "OMP-DC" RELATED [EC:4.1.1.23] synonym: "OMPdcase activity" EXACT [EC:4.1.1.23] synonym: "orotate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotate monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine 5'-phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine phosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-monophosphate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase (UMP-forming)" EXACT [EC:4.1.1.23] synonym: "orotidine-5'-phosphate carboxy-lyase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic acid decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotidylic decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "orotodylate decarboxylase activity" EXACT [EC:4.1.1.23] synonym: "UMP synthase activity" EXACT [EC:4.1.1.23] synonym: "uridine 5'-monophosphate synthase activity" EXACT [EC:4.1.1.23] xref: EC:4.1.1.23 xref: MetaCyc:OROTPDECARB-RXN xref: Reactome:12548 "orotidine-5'-phosphate decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004591 name: oxoglutarate dehydrogenase (succinyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate + lipoamide = S-succinyldihydrolipoamide + CO2." [EC:1.2.4.2] subset: gosubset_prok synonym: "2-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate: lipoate oxidoreductase activity" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:dihydrolipoyllysine-residue succinyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-succinylating)" EXACT [EC:1.2.4.2] synonym: "2-oxoglutarate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-succinylating) activity" EXACT [EC:1.2.4.2] synonym: "AKGDH activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric acid dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "alpha-oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "ketoglutaric dehydrogenase activity" EXACT [EC:1.2.4.2] synonym: "OGDC activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate decarboxylase activity" EXACT [EC:1.2.4.2] synonym: "oxoglutarate dehydrogenase (lipoamide) activity" EXACT [] synonym: "oxoglutarate dehydrogenase activity" EXACT [EC:1.2.4.2] xref: EC:1.2.4.2 xref: MetaCyc:2OXOGLUTDECARB-RXN is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004592 name: pantoate-beta-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-pantoate + beta-alanine = AMP + diphosphate + (R)-pantothenate." [EC:6.3.2.1] subset: gosubset_prok synonym: "(R)-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "D-pantoate:beta-alanine ligase (AMP-forming)" EXACT [EC:6.3.2.1] synonym: "pantoate-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantoic-activating enzyme activity" RELATED [EC:6.3.2.1] synonym: "pantothenate synthetase activity" EXACT [EC:6.3.2.1] xref: EC:6.3.2.1 xref: MetaCyc:PANTOATE-BETA-ALANINE-LIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004593 name: pantothenase activity namespace: molecular_function def: "Catalysis of the reaction: pantothenate + H2O = pantoate + beta-alanine." [EC:3.5.1.22] synonym: "(R)-pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate amidohydrolase activity" EXACT [EC:3.5.1.22] synonym: "pantothenate hydrolase activity" EXACT [EC:3.5.1.22] xref: EC:3.5.1.22 xref: MetaCyc:PANTOTHENASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0004594 name: pantothenate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantothenate = ADP + D-4'-phosphopantothenate." [EC:2.7.1.33] subset: gosubset_prok synonym: "ATP:(R)-pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "ATP:pantothenate 4'-phosphotransferase activity" EXACT [EC:2.7.1.33] synonym: "D-pantothenate kinase activity" EXACT [EC:2.7.1.33] synonym: "pantothenate kinase (phosphorylating) activity" EXACT [EC:2.7.1.33] synonym: "pantothenic acid kinase activity" EXACT [EC:2.7.1.33] xref: EC:2.7.1.33 xref: MetaCyc:PANTOTHENATE-KIN-RXN xref: Reactome:12562 "pantothenate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004595 name: pantetheine-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pantetheine 4'-phosphate = diphosphate + dephospho-CoA." [EC:2.7.7.3] subset: gosubset_prok synonym: "3'-dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-4'-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "ATP:pantetheine-phosphate adenylyltransferase activity" EXACT [] synonym: "dephospho-CoA diphosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-CoA pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "dephospho-coenzyme A pyrophosphorylase activity" EXACT [EC:2.7.7.3] synonym: "pantetheine phosphate adenylyltransferase activity" EXACT [EC:2.7.7.3] synonym: "phosphopantetheine adenylyltransferase activity" EXACT [] synonym: "PPAT activity" EXACT [EC:2.7.7.3] xref: EC:2.7.7.3 xref: MetaCyc:PANTEPADENYLYLTRAN-RXN xref: Reactome:12566 "pantetheine-phosphate adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004596 name: peptide alpha-N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the acetylation of the N-terminal amino acid residue of a peptide or protein, according to the reaction: acetyl-CoA + peptide = CoA + N-alpha-acetylpeptide." [EC:2.3.1.88, GOC:mah] subset: gosubset_prok synonym: "acetyl-CoA:peptide alpha-N-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "acetyl-CoA:peptide nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "amino-terminal amino acid-acetylating enzyme activity" RELATED [EC:2.3.1.88] synonym: "beta-endorphin acetyltransferase activity" NARROW [EC:2.3.1.88] synonym: "N(alpha)-acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "nalpha-acetyltransferase activity" EXACT [EC:2.3.1.88] synonym: "NAT activity" RELATED [EC:2.3.1.88] synonym: "peptide acetyltransferase activity" RELATED [EC:2.3.1.88] synonym: "protein N-terminal acetyltransferase activity" EXACT [EC:2.3.1.88] xref: EC:2.3.1.88 xref: MetaCyc:PEPTIDE-ALPHA-N-ACETYLTRANSFERASE-RXN is_a: GO:0034212 ! peptide N-acetyltransferase activity [Term] id: GO:0004597 name: peptide-aspartate beta-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: peptide L-aspartate + 2-oxoglutarate + O2 = peptide 3-hydroxy-L-aspartate + succinate + CO2." [EC:1.14.11.16] subset: gosubset_prok synonym: "aspartate beta-hydroxylase activity" EXACT [EC:1.14.11.16] synonym: "aspartyl/asparaginyl beta-hydroxylase activity" RELATED [EC:1.14.11.16] synonym: "aspartylpeptide beta-dioxygenase activity" EXACT [EC:1.14.11.16] synonym: "peptide-L-aspartate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating) activity" EXACT [EC:1.14.11.16] xref: EC:1.14.11.16 xref: MetaCyc:PEPTIDE-ASPARTATE-BETA-DIOXYGENASE-RXN is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0004598 name: peptidylamidoglycolate lyase activity namespace: molecular_function def: "Catalysis of the reaction: peptidylamidoglycolate = peptidyl amide + glyoxylate." [EC:4.3.2.5] synonym: "alpha-hydroxyglycine amidating dealkylase activity" EXACT [EC:4.3.2.5] synonym: "HGAD" RELATED [EC:4.3.2.5] synonym: "PAL" RELATED [EC:4.3.2.5] synonym: "peptidyl-alpha-hydroxyglycine alpha-amidating lyase activity" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase (glyoxylate-forming)" EXACT [EC:4.3.2.5] synonym: "peptidylamidoglycolate peptidylamide-lyase activity" EXACT [EC:4.3.2.5] synonym: "PGL" RELATED [EC:4.3.2.5] xref: EC:4.3.2.5 xref: MetaCyc:PEPTIDYLAMIDOGLYCOLATE-LYASE-RXN is_a: GO:0016842 ! amidine-lyase activity [Term] id: GO:0004600 name: cyclophilin namespace: molecular_function def: "OBSOLETE. A protein to which cyclosporin A (an immunosuppressant) binds. Possesses peptidyl-prolyl isomerase activity." [EC:5.2.1.8, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0003755 consider: GO:0016018 [Term] id: GO:0004601 name: peroxidase activity namespace: molecular_function alt_id: GO:0016685 alt_id: GO:0016686 alt_id: GO:0016687 alt_id: GO:0016693 def: "Catalysis of the reaction: donor + H2O2 = oxidized donor + 2 H2O." [EC:1.11.1.7] subset: gosubset_prok synonym: "bacterial catalase-peroxidase activity" NARROW [] synonym: "donor:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.7] synonym: "eosinophil peroxidase activity" NARROW [] synonym: "extensin peroxidase" NARROW [EC:1.11.1.7] synonym: "guaiacol peroxidase" NARROW [EC:1.11.1.7] synonym: "heme peroxidase" NARROW [EC:1.11.1.7] synonym: "horseradish peroxidase (HRP)" NARROW [EC:1.11.1.7] synonym: "japanese radish peroxidase" NARROW [EC:1.11.1.7] synonym: "lactoperoxidase activity" NARROW [] synonym: "MPO" RELATED [EC:1.11.1.7] synonym: "myeloperoxidase activity" NARROW [] synonym: "oxyperoxidase activity" EXACT [EC:1.11.1.7] synonym: "peroxidase reaction" EXACT [] synonym: "protoheme peroxidase" NARROW [EC:1.11.1.7] synonym: "pyrocatechol peroxidase" NARROW [EC:1.11.1.7] synonym: "scopoletin peroxidase" NARROW [EC:1.11.1.7] synonym: "secretory plant peroxidase activity" NARROW [] synonym: "thiocyanate peroxidase" NARROW [EC:1.11.1.7] synonym: "verdoperoxidase" NARROW [EC:1.11.1.7] xref: EC:1.11.1.- xref: EC:1.11.1.7 xref: MetaCyc:PEROXID-RXN xref: Reactome:4411 "peroxidase activity" is_a: GO:0016209 ! antioxidant activity is_a: GO:0016684 ! oxidoreductase activity, acting on peroxide as acceptor [Term] id: GO:0004602 name: glutathione peroxidase activity namespace: molecular_function alt_id: GO:0016224 def: "Catalysis of the reaction: 2 glutathione + H2O2 = oxidized glutathione + 2 H2O." [EC:1.11.1.9] subset: gosubset_prok synonym: "glutathione:hydrogen-peroxide oxidoreductase activity" EXACT [EC:1.11.1.9] synonym: "GSH peroxidase activity" EXACT [EC:1.11.1.9] synonym: "non-selenium glutathione peroxidase activity" NARROW [] synonym: "reduced glutathione peroxidase activity" EXACT [EC:1.11.1.9] synonym: "selenium-glutathione peroxidase activity" EXACT [EC:1.11.1.9] xref: EC:1.11.1.9 xref: MetaCyc:GLUTATHIONE-PEROXIDASE-RXN xref: Reactome:13237 "glutathione peroxidase activity" is_a: GO:0004601 ! peroxidase activity [Term] id: GO:0004603 name: phenylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phenylethanolamine = S-adenosyl-L-homocysteine + N-methylphenylethanolamine." [EC:2.1.1.28] synonym: "noradrenalin N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "noradrenaline N-methyltransferase activity" RELATED [EC:2.1.1.28] synonym: "norepinephrine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "norepinephrine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "phenethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] synonym: "S-adenosyl-L-methionine:phenylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.28] xref: EC:2.1.1.28 xref: MetaCyc:2.1.1.28-RXN xref: Reactome:13238 "phenylethanolamine N-methyltransferase activity" is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004604 name: phosphoadenylyl-sulfate reductase (thioredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + sulfite + thioredoxin disulfide = 3'-phosphoadenosine 5'-phosphosulfate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin; 3'-phosphoadenosine 5'-phosphosulfate is also known as PAPS." [EC:1.8.4.8] subset: gosubset_prok synonym: "3'-phosphoadenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:oxidized-thioredoxin oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "adenosine 3',5'-bisphosphate,sulfite:thioredoxin-disulfide oxidoreductase (3'-phosphoadenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.4.8] synonym: "PAdoPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase activity" EXACT [EC:1.8.4.8] synonym: "PAPS reductase, thioredoxin-dependent activity" EXACT [EC:1.8.4.8] synonym: "PAPS sulfotransferase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenosine-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "phosphoadenylyl-sulphate reductase (thioredoxin) activity" EXACT [] synonym: "thioredoxin:3'-phospho-adenylylsulfate reductase activity" EXACT [EC:1.8.4.8] synonym: "thioredoxin:adenosine 3'-phosphate 5'-phosphosulfate reductase activity" EXACT [EC:1.8.4.8] xref: EC:1.8.4.8 xref: MetaCyc:1.8.4.8-RXN is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0004605 name: phosphatidate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + phosphatidate = diphosphate + CDP-diacylglycerol." [EC:2.7.7.41] subset: gosubset_prok synonym: "CDP diglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "CDP-DG" RELATED [EC:2.7.7.41] synonym: "CDP-diacylglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CDP-diacylglycerol synthase activity" EXACT [] synonym: "CDP-diglyceride diphosphorylase activity" EXACT [] synonym: "CDP-diglyceride pyrophosphorylase activity" EXACT [] synonym: "CDP-diglyceride synthase activity" EXACT [] synonym: "CDP-diglyceride synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP-diacylglycerol synthetase activity" EXACT [EC:2.7.7.41] synonym: "CTP:1,2-diacylglycerophosphate-cytidyl transferase activity" EXACT [EC:2.7.7.41] synonym: "CTP:phosphatidate cytidylyltransferase activity" EXACT [EC:2.7.7.41] synonym: "cytidine diphosphoglyceride pyrophosphorylase activity" EXACT [EC:2.7.7.41] synonym: "DAG synthetase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidate cytidyltransferase activity" EXACT [EC:2.7.7.41] synonym: "phosphatidic acid cytidylyltransferase activity" EXACT [EC:2.7.7.41] xref: EC:2.7.7.41 xref: MetaCyc:CDPDIGLYSYN-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0004607 name: phosphatidylcholine-sterol O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + a sterol = a sterol ester + 1-acylglycerophosphocholine." [EC:2.3.1.43] subset: gosubset_prok synonym: "LCAT (lecithin-cholesterol acyltransferase)" RELATED [EC:2.3.1.43] synonym: "LCAT activity" EXACT [EC:2.3.1.43] synonym: "lecithin--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "lecithin:cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phosphatidylcholine:sterol O-acyltransferase activity" EXACT [EC:2.3.1.43] synonym: "phospholipid--cholesterol acyltransferase activity" EXACT [EC:2.3.1.43] xref: EC:2.3.1.43 xref: MetaCyc:2.3.1.43-RXN xref: Reactome:13245 "phosphatidylcholine-sterol O-acyltransferase activity" is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004608 name: phosphatidylethanolamine N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phosphatidylethanolamine = S-adenosyl-L-homocysteine + phosphatidyl-N-methylethanolamine." [EC:2.1.1.17] subset: gosubset_prok synonym: "lipid methyl transferase activity" EXACT [EC:2.1.1.17] synonym: "LMTase activity" EXACT [EC:2.1.1.17] synonym: "PEMT" RELATED [EC:2.1.1.17] synonym: "phosphatidylethanolamine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-N-methylase activity" EXACT [EC:2.1.1.17] synonym: "phosphatidylethanolamine-S-adenosylmethionine methyltransferase activity" EXACT [EC:2.1.1.17] synonym: "S-adenosyl-L-methionine:phosphatidylethanolamine N-methyltransferase activity" EXACT [EC:2.1.1.17] xref: EC:2.1.1.17 xref: MetaCyc:2.1.1.17-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004609 name: phosphatidylserine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidyl-L-serine = phosphatidylethanolamine + CO2." [EC:4.1.1.65] subset: gosubset_prok synonym: "phosphatidyl-L-serine carboxy-lyase (phosphatidylethanolamine-forming)" EXACT [EC:4.1.1.65] synonym: "phosphatidyl-L-serine carboxy-lyase activity" EXACT [EC:4.1.1.65] synonym: "PS decarboxylase activity" EXACT [EC:4.1.1.65] xref: EC:4.1.1.65 xref: MetaCyc:PHOSPHASERDECARB-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004610 name: phosphoacetylglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 1-phosphate = N-acetyl-D-glucosamine 6-phosphate." [EC:5.4.2.3] subset: gosubset_prok synonym: "acetylaminodeoxyglucose phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "acetylglucosamine phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetyl-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.3] synonym: "N-acetylglucosamine-phosphate mutase activity" EXACT [EC:5.4.2.3] synonym: "phospho-N-acetylglucosamine mutase activity" EXACT [EC:5.4.2.3] xref: EC:5.4.2.3 xref: MetaCyc:PHOSACETYLGLUCOSAMINEMUT-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004611 name: phosphoenolpyruvate carboxykinase activity namespace: molecular_function def: "Catalysis of the reaction: source of phosphate + oxaloacetate = phosphoenolpyruvate + CO2." [EC:4.1.1.-] subset: gosubset_prok synonym: "PEP carboxykinase activity" EXACT [EC:4.1.1.-] synonym: "PEPCK activity" EXACT [EC:4.1.1.-] synonym: "phosphopyruvate carboxylase activity" EXACT [EC:4.1.1.-] xref: EC:4.1.1.- xref: MetaCyc:4.1.1.32-RXN xref: MetaCyc:PEPCARBOXYKIN-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004612 name: phosphoenolpyruvate carboxykinase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + oxaloacetate = ADP + phosphoenolpyruvate + CO2." [EC:4.1.1.49] subset: gosubset_prok synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.49] synonym: "ATP:oxaloacetate carboxy-lyase (transphosphorylating; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.49] synonym: "PEPCK (ATP)" RELATED [EC:4.1.1.49] synonym: "PEPK" RELATED [EC:4.1.1.49] synonym: "phosphoenolpyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase" BROAD [EC:4.1.1.49] synonym: "phosphopyruvate carboxykinase (adenosine triphosphate)" EXACT [EC:4.1.1.49] synonym: "phosphopyruvate carboxylase (ATP)" EXACT [EC:4.1.1.49] xref: EC:4.1.1.49 xref: MetaCyc:PEPCARBOXYKIN-RXN is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004613 name: phosphoenolpyruvate carboxykinase (GTP) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + oxaloacetate = GDP + phosphoenolpyruvate + CO2." [EC:4.1.1.32] subset: gosubset_prok synonym: "GTP:oxaloacetate carboxy-lyase (adding GTP; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.32] synonym: "GTP:oxaloacetate carboxy-lyase (transphosphorylating)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvate carboxylase (GTP)" EXACT [] synonym: "phosphoenolpyruvic carboxykinase" BROAD [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxykinase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphoenolpyruvic carboxylase (GTP)" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate (guanosine triphosphate) carboxykinase activity" EXACT [EC:4.1.1.32] synonym: "phosphopyruvate carboxylase (GTP)" EXACT [EC:4.1.1.32] xref: EC:4.1.1.32 xref: MetaCyc:4.1.1.32-RXN xref: Reactome:13265 "phosphoenolpyruvate carboxykinase (GTP) activity" is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0004614 name: phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-D-glucose 1-phosphate = alpha-D-glucose 6-phosphate." [EC:5.4.2.2] subset: gosubset_prok synonym: "alpha-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "glucose phosphomutase activity" EXACT [EC:5.4.2.2] synonym: "phosphoglucose mutase activity" EXACT [EC:5.4.2.2] xref: EC:5.4.2.2 xref: MetaCyc:PHOSPHOGLUCMUT-RXN xref: Reactome:13266 "phosphoglucomutase activity" is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004615 name: phosphomannomutase activity namespace: molecular_function alt_id: GO:0008971 def: "Catalysis of the reaction: D-mannose 1-phosphate = D-mannose 6-phosphate." [EC:5.4.2.8] subset: gosubset_prok synonym: "alpha-D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "D-mannose 1,6-phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "mannose phosphomutase activity" EXACT [EC:5.4.2.8] synonym: "phosphomannose mutase activity" EXACT [EC:5.4.2.8] xref: EC:5.4.2.8 xref: MetaCyc:PHOSMANMUT-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004616 name: phosphogluconate dehydrogenase (decarboxylating) activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = D-ribulose 5-phosphate + CO2 + NADPH + H+." [EC:1.1.1.44] subset: gosubset_prok synonym: "6-phospho-D-gluconate dehydrogenase activity" EXACT [EC:1.1.1.44] synonym: "6-phospho-D-gluconate:NADP+ 2-oxidoreductase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconate dehydrogenase (decarboxylating)" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic carboxylase activity" EXACT [EC:1.1.1.44] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.44] synonym: "6PGD activity" EXACT [EC:1.1.1.44] synonym: "phosphogluconic acid dehydrogenase activity" EXACT [EC:1.1.1.44] xref: EC:1.1.1.44 xref: MetaCyc:6PGLUCONDEHYDROG-RXN xref: Reactome:13269 "phosphogluconate dehydrogenase (decarboxylating) activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004617 name: phosphoglycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phosphoglycerate + NAD+ = 3-phosphohydroxypyruvate + NADH + H+." [EC:1.1.1.95] subset: gosubset_prok synonym: "3-phospho-D-glycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglycerate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "3-phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "3PHP reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-KG reductase activity" EXACT [EC:1.1.1.95] synonym: "alpha-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "alphaKG reductase activity" EXACT [EC:1.1.1.95] synonym: "D- and L-HGA" RELATED [EC:1.1.1.95] synonym: "D-3-phosphoglycerate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "D-3-phosphoglycerate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "glycerate 3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "glycerate-1,3-phosphate dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "PGDH activity" EXACT [EC:1.1.1.95] synonym: "phosphoglycerate oxidoreductase activity" EXACT [EC:1.1.1.95] synonym: "phosphoglyceric acid dehydrogenase activity" EXACT [EC:1.1.1.95] synonym: "SerA" RELATED [EC:1.1.1.95] synonym: "SerA 3PG dehydrogenase activity" EXACT [EC:1.1.1.95] xref: EC:1.1.1.95 xref: MetaCyc:PGLYCDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004618 name: phosphoglycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-phospho-D-glycerate = ADP + 3-phospho-D-glyceroyl phosphate." [EC:2.7.2.3] subset: gosubset_prok synonym: "3-PGK" RELATED [EC:2.7.2.3] synonym: "3-phosphoglycerate kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglycerate phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric acid phosphokinase activity" EXACT [EC:2.7.2.3] synonym: "3-phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "ATP-3-phospho-D-glycerate-1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:3-phospho-D-glycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "ATP:D-3-phosphoglycerate 1-phosphotransferase activity" EXACT [EC:2.7.2.3] synonym: "glycerate 3-phosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "glycerophosphate kinase activity" EXACT [EC:2.7.2.3] synonym: "PGK" RELATED [EC:2.7.2.3] synonym: "phosphoglyceric acid kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglyceric kinase activity" EXACT [EC:2.7.2.3] synonym: "phosphoglycerokinase activity" EXACT [EC:2.7.2.3] xref: EC:2.7.2.3 xref: MetaCyc:PHOSGLYPHOS-RXN xref: Reactome:13282 "phosphoglycerate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0004619 name: phosphoglycerate mutase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = 3-phospho-D-glycerate." [EC:5.4.2.1] subset: gosubset_prok synonym: "bisphosphoglyceromutase" RELATED [EC:5.4.2.1] synonym: "D-phosphoglycerate 2,3-phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "diphosphoglycomutase" RELATED [EC:5.4.2.1] synonym: "GriP mutase" NARROW [EC:5.4.2.1] synonym: "monophosphoglycerate mutase activity" EXACT [EC:5.4.2.1] synonym: "monophosphoglyceromutase activity" EXACT [EC:5.4.2.1] synonym: "MPGM" RELATED [EC:5.4.2.1] synonym: "PGA mutase activity" EXACT [EC:5.4.2.1] synonym: "PGAM activity" EXACT [EC:5.4.2.1] synonym: "PGM" EXACT [] synonym: "phosphoglycerate phosphomutase activity" EXACT [EC:5.4.2.1] synonym: "phosphoglyceromutase activity" EXACT [EC:5.4.2.1] xref: EC:5.4.2.1 xref: MetaCyc:3PGAREARR-RXN xref: Reactome:13285 "phosphoglycerate mutase activity" is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0004620 name: phospholipase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a glycerophospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:3.1.1.- is_a: GO:0016298 ! lipase activity [Term] id: GO:0004621 name: glycosylphosphatidylinositol phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: glycoprotein phosphatidylinositol + H2O = phosphatidate + glycoprotein inositol." [EC:3.1.4.50] synonym: "glycoprotein phospholipase D activity" EXACT [] synonym: "glycoprotein-phosphatidylinositol phosphatidohydrolase activity" EXACT [EC:3.1.4.50] synonym: "GPI-PLD activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-glycan-specific phospholipase D activity" EXACT [EC:3.1.4.50] synonym: "phosphatidylinositol-specific phospholipase D activity" EXACT [EC:3.1.4.50] xref: EC:3.1.4.50 xref: MetaCyc:GLYCOPROTEIN-PHOSPHOLIPASE-D-RXN is_a: GO:0004630 ! phospholipase D activity [Term] id: GO:0004622 name: lysophospholipase activity namespace: molecular_function alt_id: GO:0045126 def: "Catalysis of the reaction: 2-lysophosphatidylcholine + H2O = glycerophosphocholine + a carboxylate." [EC:3.1.1.5] subset: gosubset_prok synonym: "2-lysophosphatidylcholine acylhydrolase activity" EXACT [EC:3.1.1.5] synonym: "lecithinase B activity" EXACT [EC:3.1.1.5] synonym: "lecitholipase activity" EXACT [EC:3.1.1.5] synonym: "lysolecithinase activity" EXACT [EC:3.1.1.5] synonym: "lysophopholipase L2" RELATED [EC:3.1.1.5] synonym: "lysophosphatidase activity" EXACT [EC:3.1.1.5] synonym: "lysophosphatidylcholine hydrolase activity" EXACT [EC:3.1.1.5] synonym: "lysophospholipase A1" RELATED [EC:3.1.1.5] synonym: "phosphatidase B" RELATED [EC:3.1.1.5] synonym: "phospholipase B activity" EXACT [EC:3.1.1.5] xref: EC:3.1.1.5 xref: MetaCyc:LYSOPHOSPHOLIPASE-RXN is_a: GO:0004091 ! carboxylesterase activity is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0004623 name: phospholipase A2 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.4] subset: gosubset_prok synonym: "cytosolic phospholipase A2 activity" NARROW [] synonym: "lecithinase A activity" EXACT [EC:3.1.1.4] synonym: "phosphatidase activity" RELATED [EC:3.1.1.4] synonym: "phosphatidolipase activity" EXACT [EC:3.1.1.4] synonym: "phosphatidylcholine 2-acylhydrolase activity" EXACT [EC:3.1.1.4] synonym: "phospholipase A" RELATED [EC:3.1.1.4] synonym: "secreted phospholipase A2 activity" NARROW [] xref: EC:3.1.1.4 xref: MetaCyc:PHOSPHOLIPASE-A2-RXN is_a: GO:0004091 ! carboxylesterase activity is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0004624 name: secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0004623 replaced_by: GO:0005576 [Term] id: GO:0004625 name: calcium-dependent secreted phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005576 replaced_by: GO:0047498 [Term] id: GO:0004626 name: cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0004623 replaced_by: GO:0005829 [Term] id: GO:0004627 name: calcium-dependent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005829 replaced_by: GO:0047498 [Term] id: GO:0004628 name: calcium-independent cytosolic phospholipase A2 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: phosphatidylcholine + H2O = 1-acylglycerophosphocholine + a fatty acid anion." [EC:3.1.1.4] comment: This term was made obsolete because it represents component and function information. is_obsolete: true replaced_by: GO:0005829 replaced_by: GO:0047499 [Term] id: GO:0004629 name: phospholipase C activity namespace: molecular_function alt_id: GO:0042298 def: "Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate." [EC:3.1.4.3, EC:3.1.4.4, GOC:mah] subset: gosubset_prok synonym: "lecithinase C activity" RELATED [EC:3.1.4.3] synonym: "lipophosphodiesterase C" RELATED [EC:3.1.4.3] synonym: "phosphatidase C" RELATED [EC:3.1.4.3] xref: MetaCyc:PHOSPHOLIPASE-C-RXN xref: Reactome:11457 "phospholipase C activity" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004630 name: phospholipase D activity namespace: molecular_function def: "Catalysis of the reaction: a phosphatidylcholine + H2O = choline + a phosphatidate." [EC:3.1.4.4] subset: gosubset_prok synonym: "choline phosphatase activity" EXACT [EC:3.1.4.4] synonym: "lecithinase D activity" EXACT [EC:3.1.4.4] synonym: "lipophosphodiesterase II activity" EXACT [EC:3.1.4.4] synonym: "phosphatidylcholine phosphatidohydrolase activity" EXACT [EC:3.1.4.4] xref: EC:3.1.4.4 xref: MetaCyc:PHOSCHOL-RXN is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004631 name: phosphomevalonate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-5-phosphomevalonate = ADP + (R)-5-diphosphomevalonate." [EC:2.7.4.2] subset: gosubset_prok synonym: "5-phosphomevalonate kinase activity" EXACT [EC:2.7.4.2] synonym: "ATP:(R)-5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "ATP:5-phosphomevalonate phosphotransferase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonate-5-phosphate kinase activity" EXACT [EC:2.7.4.2] synonym: "mevalonic acid phosphate kinase activity" EXACT [EC:2.7.4.2] xref: EC:2.7.4.2 xref: MetaCyc:PHOSPHOMEVALONATE-KINASE-RXN xref: Reactome:13380 "phosphomevalonate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0004632 name: phosphopantothenate--cysteine ligase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + (R)-4'-phosphopantothenate + L-cysteine = CMP + diphosphate + (R)-4'-phosphopantothenoyl-L-cysteine. Cysteine can be replaced by some of its derivatives." [EC:6.3.2.5] subset: gosubset_prok synonym: "(R)-4'-phosphopantothenate:L-cysteine ligase activity" EXACT [EC:6.3.2.5] synonym: "phosphopantothenate-cysteine ligase activity" EXACT [] synonym: "phosphopantothenoylcysteine synthetase activity" EXACT [] xref: EC:6.3.2.5 xref: MetaCyc:P-PANTOCYSLIG-RXN xref: Reactome:13381 "phosphopantothenate--cysteine ligase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004633 name: phosphopantothenoylcysteine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: N-((R)-4-phosphopantothenoyl)-L-cysteine = pantetheine 4'-phosphate + CO2." [EC:4.1.1.36] subset: gosubset_prok synonym: "4-phosphopantothenoyl-L-cysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "4-phosphopantotheoylcysteine decarboxylase activity" EXACT [EC:4.1.1.36] synonym: "N-((R)-4'-phosphopantothenoyl)-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase (pantotheine-4'-phosphate-forming)" EXACT [EC:4.1.1.36] synonym: "N-[(R)-4'-phosphopantothenoyl]-L-cysteine carboxy-lyase activity" EXACT [EC:4.1.1.36] synonym: "PPC-decarboxylase activity" EXACT [EC:4.1.1.36] xref: EC:4.1.1.36 xref: MetaCyc:P-PANTOCYSDECARB-RXN xref: Reactome:13382 "phosphopantothenoylcysteine decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004634 name: phosphopyruvate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-D-glycerate = phosphoenolpyruvate + H2O." [EC:4.2.1.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "14-3-2-protein" RELATED [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase (phosphoenolpyruvate-forming)" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate hydro-lyase activity" EXACT [EC:4.2.1.11] synonym: "2-phospho-D-glycerate-hydrolase activity" EXACT [] synonym: "2-phosphoglycerate dehydratase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglycerate enolase activity" EXACT [EC:4.2.1.11] synonym: "2-phosphoglyceric dehydratase activity" EXACT [EC:4.2.1.11] synonym: "enolase activity" EXACT [EC:4.2.1.11] synonym: "gamma-enolase activity" EXACT [EC:4.2.1.11] synonym: "nervous-system specific enolase" NARROW [EC:4.2.1.11] synonym: "phosphoenolpyruvate hydratase activity" EXACT [EC:4.2.1.11] xref: EC:4.2.1.11 xref: MetaCyc:2PGADEHYDRAT-RXN xref: Reactome:13384 "phosphopyruvate hydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004635 name: phosphoribosyl-AMP cyclohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: 1-(5-phosphoribosyl)-AMP + H2O = 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino)imidazole-4-carboxamide." [EC:3.5.4.19] subset: gosubset_prok synonym: "1-(5-phospho-D-ribosyl)-AMP 1,6-hydrolase activity" EXACT [EC:3.5.4.19] synonym: "phosphoribosyladenosine monophosphate cyclohydrolase activity" EXACT [EC:3.5.4.19] synonym: "PRAMP-cyclohydrolase activity" EXACT [EC:3.5.4.19] xref: EC:3.5.4.19 xref: MetaCyc:HISTCYCLOHYD-RXN is_a: GO:0019238 ! cyclohydrolase activity [Term] id: GO:0004636 name: phosphoribosyl-ATP diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5-phosphoribosyl-ATP + H2O = 5-phosphoribosyl-AMP + diphosphate." [EC:3.6.1.31] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-ATP diphosphohydrolase activity" EXACT [EC:3.6.1.31] synonym: "phosphoribosyl-ATP pyrophosphatase activity" EXACT [] synonym: "phosphoribosyladenosine triphosphate pyrophosphatase activity" EXACT [EC:3.6.1.31] xref: EC:3.6.1.31 xref: MetaCyc:HISTPRATPHYD-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0004637 name: phosphoribosylamine-glycine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-phospho-D-ribosylamine + glycine = ADP + phosphate + N1-(5-phospho-D-ribosyl)glycinamide." [EC:6.3.4.13] subset: gosubset_prok synonym: "2-amino-N-ribosylacetamide 5'-phosphate kinosynthase activity" EXACT [EC:6.3.4.13] synonym: "5'-phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "5-phospho-D-ribosylamine:glycine ligase (ADP-forming)" EXACT [EC:6.3.4.13] synonym: "GAR" RELATED [EC:6.3.4.13] synonym: "GAR synthetase activity" EXACT [EC:6.3.4.13] synonym: "GARS activity" EXACT [EC:6.3.4.13] synonym: "glycinamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "glycineamide ribonucleotide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycinamide synthetase activity" EXACT [EC:6.3.4.13] synonym: "phosphoribosylglycineamide synthetase activity" EXACT [EC:6.3.4.13] xref: EC:6.3.4.13 xref: MetaCyc:GLYRIBONUCSYN-RXN xref: Reactome:13392 "phosphoribosylamine-glycine ligase activity" is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004638 name: phosphoribosylaminoimidazole carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate = 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO2." [EC:4.1.1.21] subset: gosubset_prok synonym: "1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase [5-amino-1-(5-phospho-D-ribosyl)imidazole-forming]" RELATED [EC:4.1.1.21] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase activity" EXACT [EC:4.1.1.21] synonym: "5-amino-1-ribosylimidazole 5-phosphate carboxylase activity" EXACT [EC:4.1.1.21] synonym: "5-phosphoribosyl-5-aminoimidazole carboxylase activity" EXACT [EC:4.1.1.21] synonym: "ADE2" RELATED [EC:4.1.1.21] synonym: "AIR carboxylase activity" EXACT [EC:4.1.1.21] synonym: "class II PurE" RELATED [EC:4.1.1.21] xref: EC:4.1.1.21 xref: MetaCyc:AIRCARBOXY-RXN xref: Reactome:13396 "phosphoribosylaminoimidazole carboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004639 name: phosphoribosylaminoimidazolesuccinocarboxamide synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + L-aspartate = ADP + phosphate + (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate." [EC:6.3.2.6] subset: gosubset_prok synonym: "4-((N-succinylamino)carbonyl)-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-(N-succinocarboxamide)-5-aminoimidazole synthetase activity" EXACT [EC:6.3.2.6] synonym: "4-[(N-succinylamino)carbonyl]-5-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate:L-aspartate ligase (ADP-forming)" EXACT [EC:6.3.2.6] synonym: "5-aminoimidazole-4-N-succinocarboxamide ribonucleotide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazole-succinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "phosphoribosylaminoimidazolesuccinocarboxamide synthetase activity" EXACT [EC:6.3.2.6] synonym: "PurC" RELATED [EC:6.3.2.6] synonym: "SAICAR synthase activity" EXACT [EC:6.3.2.6] synonym: "SAICAR synthetase activity" EXACT [EC:6.3.2.6] synonym: "SAICARs activity" EXACT [EC:6.3.2.6] xref: EC:6.3.2.6 xref: MetaCyc:SAICARSYN-RXN xref: Reactome:13398 "phosphoribosylaminoimidazolesuccinocarboxamide synthase activity" is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004640 name: phosphoribosylanthranilate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: N-(5-phospho-beta-D-ribosyl)-anthranilate = 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate." [EC:5.3.1.24] subset: gosubset_prok synonym: "IGPS:PRAI (indole-3-glycerol-phosphate synthetase/N-5'-phosphoribosylanthranilate isomerase complex)" RELATED [EC:5.3.1.24] synonym: "N-(5'-phosphoribosyl)anthranilate isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.24] synonym: "N-(5-phospho-beta-D-ribosyl)anthranilate ketol-isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRA isomerase activity" EXACT [EC:5.3.1.24] synonym: "PRAI activity" EXACT [EC:5.3.1.24] xref: EC:5.3.1.24 xref: MetaCyc:PRAISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004641 name: phosphoribosylformylglycinamidine cyclo-ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-(formamido)-N1-(5-phospho-D-ribosyl)acetamidine = ADP + phosphate + 5-amino-1-(5-phospho-D-ribosyl)imidazole." [EC:6.3.3.1] subset: gosubset_prok synonym: "2-(formamido)-1-N-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "2-(formamido)-N1-(5-phosphoribosyl)acetamidine cyclo-ligase (ADP-forming)" EXACT [EC:6.3.3.1] synonym: "5'-aminoimidazole ribonucleotide synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthase activity" EXACT [EC:6.3.3.1] synonym: "AIR synthetase activity" EXACT [EC:6.3.3.1] synonym: "AIRS activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosyl-aminoimidazole synthetase activity" EXACT [EC:6.3.3.1] synonym: "phosphoribosylaminoimidazole synthetase activity" EXACT [EC:6.3.3.1] xref: EC:6.3.3.1 xref: MetaCyc:AIRS-RXN xref: Reactome:13434 "phosphoribosylformylglycinamidine cyclo-ligase activity" is_a: GO:0016882 ! cyclo-ligase activity [Term] id: GO:0004642 name: phosphoribosylformylglycinamidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 5'-phosphoribosylformylglycinamide + L-glutamine + H2O = ADP + phosphate + 5'-phosphoribosylformylglycinamidine + L-glutamate." [EC:6.3.5.3] subset: gosubset_prok synonym: "2-N-formyl-1-N-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "5'-phosphoribosylformylglycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "FGAM synthase activity" EXACT [EC:6.3.5.3] synonym: "FGAM synthetase activity" EXACT [EC:6.3.5.3] synonym: "FGAR amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "FGARAT activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribonucloetide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "formylglycinamide ribotide amidotransferase activity" EXACT [EC:6.3.5.3] synonym: "N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide:L-glutamine amido-ligase (ADP-forming)" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycinamidine synthetase activity" EXACT [EC:6.3.5.3] synonym: "phosphoribosylformylglycineamidine synthetase activity" EXACT [EC:6.3.5.3] xref: EC:6.3.5.3 xref: MetaCyc:FGAMSYN-RXN xref: Reactome:13437 "phosphoribosylformylglycinamidine synthase activity" is_a: GO:0016884 ! carbon-nitrogen ligase activity, with glutamine as amido-N-donor [Term] id: GO:0004643 name: phosphoribosylaminoimidazolecarboxamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4-imidazolecarboxamide = tetrahydrofolate + 5'-phosphoribosyl-5-formamido-4-imidazolecarboxamide." [EC:2.1.2.3] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazole-carboxamide N-formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "10-formyltetrahydrofolate:5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5'-phosphoribosyl-5-amino-4-imidazolecarboxamide formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-1-ribosyl-4-imidazolecarboxamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "5-amino-4-imidazolecarboxamide ribotide transformylase activity" EXACT [EC:2.1.2.3] synonym: "AICAR formyltransferase activity" EXACT [EC:2.1.2.3] synonym: "AICAR transformylase activity" EXACT [EC:2.1.2.3] synonym: "aminoimidazolecarboxamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.3] xref: EC:2.1.2.3 xref: MetaCyc:AICARTRANSFORM-RXN xref: Reactome:13439 "phosphoribosylaminoimidazolecarboxamide formyltransferase activity" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004644 name: phosphoribosylglycinamide formyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide." [EC:2.1.2.2] subset: gosubset_prok synonym: "10-formyltetrahydrofolate:5'-phosphoribosylglycinamide N-formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "2-amino-N-ribosylacetamide 5'-phosphate transformylase activity" EXACT [EC:2.1.2.2] synonym: "5'-phosphoribosylglycinamide transformylase activity" EXACT [EC:2.1.2.2] synonym: "5,10-methenyltetrahydrofolate:2-amino-N-ribosylacetamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] synonym: "GAR formyltransferase activity" EXACT [EC:2.1.2.2] synonym: "GAR TFase activity" EXACT [EC:2.1.2.2] synonym: "GAR transformylase activity" EXACT [EC:2.1.2.2] synonym: "GART activity" EXACT [EC:2.1.2.2] synonym: "glycinamide ribonucleotide transformylase activity" EXACT [EC:2.1.2.2] xref: EC:2.1.2.2 xref: MetaCyc:GART-RXN xref: Reactome:13440 "phosphoribosylglycinamide formyltransferase activity" is_a: GO:0016742 ! hydroxymethyl-, formyl- and related transferase activity [Term] id: GO:0004645 name: phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 1,4-alpha-D-glucosyl(n) + phosphate = 1,4-alpha-D-glucosyl(n-1) + alpha-D-glucose 1-phosphate. The name should be qualified in each instance by adding the name of the natural substrate, e.g. maltodextrin phosphorylase, starch phosphorylase, glycogen phosphorylase." [EC:2.4.1.1] subset: gosubset_prok synonym: "1,4-alpha-D-glucan:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.1] synonym: "1,4-alpha-glucan phosphorylase activity" EXACT [EC:2.4.1.1] synonym: "alpha-glucan phosphorylase" BROAD [EC:2.4.1.1] synonym: "amylopectin phosphorylase" NARROW [EC:2.4.1.1] synonym: "amylophosphorylase activity" NARROW [EC:2.4.1.1] synonym: "glucan phosphorylase" NARROW [EC:2.4.1.1] synonym: "glucosan phosphorylase" NARROW [EC:2.4.1.1] synonym: "granulose phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase" NARROW [EC:2.4.1.1] synonym: "muscle phosphorylase a and b activity" NARROW [EC:2.4.1.1] synonym: "myophosphorylase" NARROW [EC:2.4.1.1] synonym: "polyphosphorylase activity" EXACT [EC:2.4.1.1] synonym: "potato phosphorylase" NARROW [EC:2.4.1.1] synonym: "starch phosphorylase" NARROW [EC:2.4.1.1] xref: EC:2.4.1.1 xref: MetaCyc:RXN-1826 is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0004647 name: phosphoserine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L(or D)-O-phosphoserine + H2O = L(or D)-serine + phosphate." [EC:3.1.3.3] subset: gosubset_prok synonym: "O-phosphoserine phosphohydrolase activity" EXACT [EC:3.1.3.3] xref: EC:3.1.3.3 xref: MetaCyc:PSERPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004648 name: O-phospho-L-serine:2-oxoglutarate aminotransferase activity namespace: molecular_function alt_id: GO:0004646 def: "Catalysis of the reaction: O-phospho-L-serine + 2-oxoglutarate = 3-phosphonooxypyruvate + L-glutamate." [EC:2.6.1.52] subset: gosubset_prok synonym: "3-O-phospho-L-serine:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "3PHP transaminase activity" EXACT [EC:2.6.1.52] synonym: "hydroxypyruvic phosphate--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "L-phosphoserine aminotransferase activity" EXACT [EC:2.6.1.52] synonym: "PdxC" RELATED [EC:2.6.1.52] synonym: "phosphohydroxypyruvate transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphohydroxypyruvic--glutamic transaminase activity" EXACT [EC:2.6.1.52] synonym: "phosphoserine aminotransferase activity" BROAD [] synonym: "phosphoserine transaminase activity" BROAD [EC:2.6.1.52] synonym: "PSAT activity" EXACT [EC:2.6.1.52] synonym: "SerC" RELATED [EC:2.6.1.52] xref: EC:2.6.1.52 xref: MetaCyc:PSERTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004649 name: poly(ADP-ribose) glycohydrolase activity namespace: molecular_function def: "Catalysis of the hydrolysis of poly(ADP-ribose) at glycosidic (1''-2') linkage of ribose-ribose bond to produce free ADP-ribose." [EC:3.2.1.143] xref: EC:3.2.1.143 xref: MetaCyc:3.2.1.143-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004650 name: polygalacturonase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,4-alpha-D-galactosiduronic linkages in pectate and other galacturonans." [EC:3.2.1.15] subset: gosubset_prok synonym: "endo-D-galacturonase activity" EXACT [] synonym: "endo-polygalacturonase activity" EXACT [] synonym: "endogalacturonase activity" EXACT [] synonym: "endopolygalacturonase activity" EXACT [] synonym: "pectin depolymerase activity" NARROW [EC:3.2.1.15] synonym: "pectin hydrolase activity" EXACT [EC:3.2.1.15] synonym: "pectin polygalacturonase activity" EXACT [EC:3.2.1.15] synonym: "pectinase activity" NARROW [EC:3.2.1.15] synonym: "pectolase activity" EXACT [EC:3.2.1.15] synonym: "poly(1,4-alpha-D-galacturonide) glycanohydrolase activity" EXACT [] synonym: "poly-alpha-1,4-galacturonide glycanohydrolase activity" EXACT [] xref: EC:3.2.1.15 xref: MetaCyc:RXN-2103 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0004651 name: polynucleotide 5'-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 5'-phosphopolynucleotide + H2O = polynucleotide + phosphate." [EC:3.1.3.33] synonym: "5'-polynucleotidase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-phosphohydrolase activity" EXACT [EC:3.1.3.33] synonym: "polynucleotide 5'-triphosphatase activity" EXACT [EC:3.1.3.33] xref: EC:3.1.3.33 xref: MetaCyc:POLYNUCLEOTIDE-5-PHOSPHATASE-RXN xref: Reactome:13463 "polynucleotide 5'-phosphatase activity" is_a: GO:0019204 ! nucleotide phosphatase activity [Term] id: GO:0004652 name: polynucleotide adenylyltransferase activity namespace: molecular_function def: "Catalysis of the template-independent extension of the 3'- end of an RNA or DNA strand by addition of one adenosine molecule at a time. Cannot initiate a chain 'de novo'. The primer, depending on the source of the enzyme, may be an RNA or DNA fragment, or oligo(A) bearing a 3'-OH terminal group." [EC:2.7.7.19] subset: gosubset_prok synonym: "adenosine triphosphate:ribonucleic acid adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "AMP polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP-polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotide adenylyltransferase activity" EXACT [EC:2.7.7.19] synonym: "ATP:polynucleotidylexotransferase activity" EXACT [EC:2.7.7.19] synonym: "NTP polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) hydrolase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) polymerase activity" EXACT [EC:2.7.7.19] synonym: "poly(A) synthetase activity" EXACT [EC:2.7.7.19] synonym: "poly-A polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate nucleotidyltransferase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylate synthetase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic acid polymerase activity" EXACT [EC:2.7.7.19] synonym: "polyadenylic polymerase activity" EXACT [EC:2.7.7.19] synonym: "RNA adenylating enzyme activity" EXACT [EC:2.7.7.19] synonym: "RNA formation factors, PF1" RELATED [EC:2.7.7.19] synonym: "terminal riboadenylate transferase activity" EXACT [EC:2.7.7.19] xref: EC:2.7.7.19 xref: MetaCyc:POLYNUCLEOTIDE-ADENYLYLTRANSFERASE-RXN xref: Reactome:72182 "polynucleotide adenylyltransferase activity" is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004653 name: polypeptide N-acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide. Catalyzes of the modification of serine or threonine residues in polypeptide chains by the transfer of a N-acetylgalactose from UDP-N-acetylgalactose to the hydroxyl group of the amino acid; it is the first step in O-glycan biosynthesis." [EC:2.4.1.41, ISBN:0879695595] synonym: "glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "polypeptide-N-acetylgalactosamine transferase activity" EXACT [EC:2.4.1.41] synonym: "protein-UDP acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-acetylgalactosamine:peptide-N-galactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetyl-D-galactosamine:polypeptide N-acetylgalactosaminyl-transferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-glycoprotein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine-protein N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:kappa-casein polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:polypeptide N-acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] synonym: "UDP-N-acetylgalactosamine:protein N-acetylgalactosaminyl transferase activity" EXACT [EC:2.4.1.41] synonym: "uridine diphosphoacetylgalactosamine-glycoprotein acetylgalactosaminyltransferase activity" EXACT [EC:2.4.1.41] xref: EC:2.4.1.41 xref: MetaCyc:2.4.1.41-RXN is_a: GO:0008376 ! acetylgalactosaminyltransferase activity [Term] id: GO:0004654 name: polyribonucleotide nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + RNA(n) = diphosphate + RNA(n+1)." [EC:2.7.7.8] subset: gosubset_prok synonym: "nucleoside diphosphate:polynucleotidyl transferase activity" EXACT [EC:2.7.7.8] synonym: "polynucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide phosphorylase activity" EXACT [EC:2.7.7.8] synonym: "polyribonucleotide:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.8] xref: EC:2.7.7.8 xref: MetaCyc:2.7.7.8-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0004655 name: porphobilinogen synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 5-aminolevulinate = porphobilinogen + 2 H2O." [EC:4.2.1.24] subset: gosubset_prok synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing)" EXACT [EC:4.2.1.24] synonym: "5-aminolevulinate hydro-lyase (adding 5-aminolevulinate and cyclizing; porphobilinogen-forming)" EXACT [EC:4.2.1.24] synonym: "5-levulinic acid dehydratase activity" EXACT [EC:4.2.1.24] synonym: "aminolevulinate dehydratase activity" EXACT [] synonym: "aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinate dehydratase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydrase activity" EXACT [EC:4.2.1.24] synonym: "delta-aminolevulinic acid dehydratase activity" EXACT [] synonym: "delta-aminolevulinic dehydratase activity" EXACT [EC:4.2.1.24] xref: EC:4.2.1.24 xref: MetaCyc:PORPHOBILSYNTH-RXN xref: Reactome:13469 "porphobilinogen synthase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004656 name: procollagen-proline 4-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-proline + 2-oxoglutarate + O2 = procollagen trans-4-hydroxy-L-proline + succinate + CO2." [EC:1.14.11.2] synonym: "collagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "hydroxylase, collagen proline activity" EXACT [EC:1.14.11.2] synonym: "peptidyl proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "procollagen-L-proline,2-oxoglutarate:oxygen oxidoreductase (4-hydroxylating) activity" EXACT [EC:1.14.11.2] synonym: "procollagen-proline,2-oxoglutarate-4-dioxygenase activity" EXACT [] synonym: "proline hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "proline protocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "proline, 2-oxoglutarate dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "proline,2-oxoglutarate 4-dioxygenase activity" BROAD [EC:1.14.11.2] synonym: "prolyl 4-hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "prolyl-glycyl-peptide, 2-oxoglutarate:oxygen oxidoreductase, 4-hydroxylating activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "prolylprotocollagen hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen hydroxylase activity" BROAD [EC:1.14.11.2] synonym: "protocollagen proline 4-hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline dioxygenase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen proline hydroxylase activity" EXACT [EC:1.14.11.2] synonym: "protocollagen prolyl hydroxylase activity" EXACT [EC:1.14.11.2] xref: EC:1.14.11.2 xref: MetaCyc:1.14.11.2-RXN is_a: GO:0019798 ! procollagen-proline dioxygenase activity is_a: GO:0031545 ! peptidyl-proline 4-dioxygenase activity [Term] id: GO:0004657 name: proline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + acceptor = (S)-1-pyrroline-5-carboxylate + reduced acceptor." [EC:1.5.99.8] subset: gosubset_prok synonym: "L-proline dehydrogenase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:(acceptor) oxidoreductase activity" EXACT [EC:1.5.99.8] synonym: "L-proline:acceptor oxidoreductase activity" EXACT [EC:1.5.99.8] xref: EC:1.5.99.8 xref: MetaCyc:RXN-7181 xref: Reactome:13472 "proline dehydrogenase activity" is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0004658 name: propionyl-CoA carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoyl-CoA + HCO3- = ADP + phosphate + (S)-methylmalonyl-CoA." [EC:6.4.1.3] subset: gosubset_prok synonym: "PCCase activity" EXACT [EC:6.4.1.3] synonym: "propanoyl-CoA:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.3] synonym: "propionyl coenzyme A carboxylase activity" EXACT [EC:6.4.1.3] xref: EC:6.4.1.3 xref: MetaCyc:PROPIONYL-COA-CARBOXY-RXN xref: Reactome:13473 "propionyl-CoA carboxylase activity" is_a: GO:0016421 ! CoA carboxylase activity [Term] id: GO:0004659 name: prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor)." [GOC:mah] subset: gosubset_prok xref: EC:2.5.1.- xref: MetaCyc:GPPSYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004660 name: protein farnesyltransferase activity namespace: molecular_function alt_id: GO:0018223 def: "Catalysis of the reaction: farnesyl diphosphate + protein-cysteine = S-farnesyl protein + diphosphate." [EC:2.5.1.58, PMID:8621375] synonym: "CAAX farnesyltransferase activity" NARROW [EC:2.5.1.58] synonym: "farnesyl-diphosphate:protein-cysteine farnesyltransferase activity" EXACT [EC:2.5.1.58] synonym: "FTase activity" EXACT [EC:2.5.1.58] synonym: "protein-cysteine farnesyltransferase activity" EXACT [] xref: EC:2.5.1.58 xref: MetaCyc:2.5.1.58-RXN is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004661 name: protein geranylgeranyltransferase activity namespace: molecular_function alt_id: GO:0018224 def: "Catalysis of the covalent addition of a geranylgeranyl (20-carbon isoprenoid) group via thioether linkages to a cysteine residue at or near the C terminus of a protein." [PMID:8621375] synonym: "protein-cysteine geranylgeranyltransferase activity" EXACT [] xref: EC:2.5.1.- is_a: GO:0008318 ! protein prenyltransferase activity [Term] id: GO:0004662 name: CAAX-protein geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate. This reaction is the formation of a thioether linkage between the C-1 atom of the geranylgeranyl group and a cysteine residue fourth from the C-terminus of the protein. The protein substrates have the C-terminal sequence CA1A2X, where the terminal residue, X, is preferably leucine and A2 should not be aromatic. Known substrates include most g-subunits of heterotrimeric G proteins and Ras-related GTPases such as members of the Ras and Rac/Rho families." [EC:2.5.1.59, PMID:8621375] synonym: "geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "geranylgeranyltransferase type I activity" EXACT [] synonym: "GGTase-I activity" EXACT [] synonym: "GGTaseI activity" EXACT [] synonym: "protein geranylgeranyltransferase type I" RELATED [EC:2.5.1.59] synonym: "type I protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.59] xref: EC:2.5.1.59 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004663 name: Rab geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 geranylgeranyl diphosphate + protein-cysteine = 2 S-geranylgeranyl-protein + 2 diphosphate. This reaction is the formation of two thioether linkages between the C-1 atom of the geranylgeranyl groups and two cysteine residues within the terminal sequence motifs XXCC, XCXC or CCXX. Known substrates include Ras-related GTPases of a single family and the Rab family." [EC:2.5.1.60, GOC:mah, PMID:8621375] synonym: "geranylgeranyl-diphosphate,geranylgeranyl-diphosphate:protein-cysteine geranyltransferase activity" EXACT [] synonym: "GGTase-II activity" EXACT [] synonym: "GGTaseII activity" EXACT [] synonym: "protein geranylgeranyltransferase type II activity" EXACT [] synonym: "Rab-protein geranylgeranyltransferase activity" EXACT [] synonym: "RabGGTase activity" EXACT [] synonym: "type II protein geranyl-geranyltransferase activity" EXACT [EC:2.5.1.60] xref: EC:2.5.1.60 xref: MetaCyc:2.5.1.60-RXN xref: MetaCyc:RXN-3701 is_a: GO:0004661 ! protein geranylgeranyltransferase activity [Term] id: GO:0004664 name: prephenate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate = phenylpyruvate + H2O + CO2." [EC:4.2.1.51] subset: gosubset_prok synonym: "prephenate hydro-lyase (decarboxylating)" EXACT [EC:4.2.1.51] synonym: "prephenate hydro-lyase (decarboxylating; phenylpyruvate-forming)" EXACT [EC:4.2.1.51] xref: EC:4.2.1.51 xref: MetaCyc:PREPHENATEDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004665 name: prephenate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: prephenate + NADP+ = 4-hydroxyphenylpyruvate + CO2 + NADPH + H+." [EC:1.3.1.13] subset: gosubset_prok synonym: "prephenate (nicotinamide adenine dinucleotide phosphate) dehydrogenase activity" EXACT [EC:1.3.1.13] synonym: "prephenate:NADP+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.13] xref: EC:1.3.1.13 xref: MetaCyc:PREPHENATE-DEHYDROGENASE-NADP+-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0004666 name: prostaglandin-endoperoxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: arachidonate + donor-H2 + 2 O2 = prostaglandin H2 + acceptor + H2O." [EC:1.14.99.1] synonym: "(5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate,hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.99.1] synonym: "(PG)H synthase activity" EXACT [EC:1.14.99.1] synonym: "fatty acid cyclooxygenase activity" EXACT [EC:1.14.99.1] synonym: "PG synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin endoperoxide synthetase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin G/H synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthase activity" EXACT [EC:1.14.99.1] synonym: "prostaglandin synthetase activity" EXACT [EC:1.14.99.1] xref: EC:1.14.99.1 xref: MetaCyc:PROSTAGLANDIN-ENDOPEROXIDE-SYNTHASE-RXN xref: Reactome:13496 "prostaglandin-endoperoxide synthase activity" is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0004667 name: prostaglandin-D synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,15-dihydroxy-11-oxoprosta-5,13-dienoate." [EC:5.3.99.2] synonym: "(5,13)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "PGD2 synthase activity" EXACT [EC:5.3.99.2] synonym: "PGH-PGD isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin D2 synthase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-H2 D-isomerase activity" EXACT [EC:5.3.99.2] synonym: "prostaglandin-R-prostaglandin D isomerase activity" EXACT [EC:5.3.99.2] xref: EC:5.3.99.2 xref: MetaCyc:PROSTAGLANDIN-D-SYNTHASE-RXN is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004668 name: protein-arginine deiminase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-arginine + H2O = protein L-citrulline + NH3." [EC:3.5.3.15] subset: gosubset_prok synonym: "peptidylarginine deiminase activity" EXACT [EC:3.5.3.15] synonym: "protein-L-arginine iminohydrolase activity" EXACT [EC:3.5.3.15] xref: EC:3.5.3.15 xref: MetaCyc:PROTEIN-ARGININE-DEIMINASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004671 name: protein C-terminal S-isoprenylcysteine carboxyl O-methyltransferase activity namespace: molecular_function alt_id: GO:0018225 def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein C-terminal S-farnesyl-L-cysteine = S-adenosyl-L-homocysteine + protein C-terminal S-farnesyl-L-cysteine methyl ester." [EC:2.1.1.100] subset: gosubset_prok synonym: " protein-S-isoprenylcysteine O-methyltransferase activity" EXACT [] synonym: "farnesyl cysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesyl-protein carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "farnesylated protein C-terminal O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "isoprenylcysteine carboxylmethyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylated protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylated protein methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxyl methyltransferase activity" RELATED [EC:2.1.1.100] synonym: "prenylcysteine carboxylmethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine carboxymethyltransferase activity" EXACT [EC:2.1.1.100] synonym: "prenylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein C-terminal farnesylcysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "protein S-farnesylcysteine C-terminal methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-adenosyl-L-methionine:protein-C-terminal-S-farnesyl-L-cysteine O-methyltransferase activity" EXACT [EC:2.1.1.100] synonym: "S-farnesylcysteine methyltransferase activity" EXACT [EC:2.1.1.100] xref: EC:2.1.1.100 xref: KEGG:R04496 xref: MetaCyc:2.1.1.100-RXN is_a: GO:0003880 ! protein C-terminal carboxyl O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004672 name: protein kinase activity namespace: molecular_function alt_id: GO:0050222 def: "Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP." [MetaCyc:PROTEIN-KINASE-RXN] comment: Note that triphosphate is used as a phosphate donor by at least one kinase. subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "protamine kinase activity" NARROW [] xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:4030 "protein kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004673 name: protein histidine kinase activity namespace: molecular_function alt_id: GO:0008896 def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein phospho-L-histidine." [EC:2.7.13.3, GOC:mah] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-phosphotransferase activity" EXACT [EC:2.7.13.3] synonym: "EnvZ" NARROW [EC:2.7.13.3] synonym: "histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine kinase activity" EXACT [] synonym: "histidine protein kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "histidine protein kinase activity" EXACT [EC:2.7.13.3] synonym: "HK1" RELATED [EC:2.7.13.3] synonym: "HP165" RELATED [EC:2.7.13.3] synonym: "protein histidine kinase (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine)" EXACT [EC:2.7.13.3] synonym: "protein kinase (histidine) (ambiguous)" EXACT [EC:2.7.13.3] synonym: "protein-histidine kinase activity" EXACT [] synonym: "Sln1p" NARROW [EC:2.7.13.3] xref: EC:2.7.13.3 xref: MetaCyc:2.7.13.3-RXN is_a: GO:0004672 ! protein kinase activity is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0004674 name: protein serine/threonine kinase activity namespace: molecular_function alt_id: GO:0004700 def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate." [GOC:bf] subset: gosubset_prok synonym: "A-kinase activity" NARROW [EC:2.7.11.1] synonym: "AP50 kinase activity" NARROW [EC:2.7.11.1] synonym: "ATP-protein transphosphorylase activity" NARROW [EC:2.7.11.1] synonym: "ATP:protein phosphotransferase (non-specific) activity" NARROW [EC:2.7.11.1] synonym: "atypical PKC activity" NARROW [] synonym: "atypical protein kinase C activity" NARROW [] synonym: "betaIIPKC" RELATED [EC:2.7.11.1] synonym: "calcium/phospholipid-dependent protein kinase activity" NARROW [EC:2.7.11.1] synonym: "casein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "cytidine 3',5'-cyclic monophosphate-responsive protein kinase activity" NARROW [EC:2.7.11.1] synonym: "dsk1" RELATED [EC:2.7.11.1] synonym: "epsilon PKC" RELATED [EC:2.7.11.1] synonym: "glycogen synthase a kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase A kinase activity" NARROW [EC:2.7.11.1] synonym: "glycogen synthase kinase activity" NARROW [EC:2.7.11.1] synonym: "HIPK2" RELATED [EC:2.7.11.1] synonym: "Hpr kinase activity" NARROW [EC:2.7.11.1] synonym: "hydroxyalkyl-protein kinase activity" NARROW [EC:2.7.11.1] synonym: "M phase-specific cdc2 kinase activity" NARROW [EC:2.7.11.1] synonym: "MAPK" RELATED [EC:2.7.11.1] synonym: "mitogen-activated protein kinase activity" BROAD [EC:2.7.11.1] synonym: "mitogen-activated S6 kinase activity" NARROW [EC:2.7.11.1] synonym: "non-specific serine/threonine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "p82 kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase B kinase kinase activity" NARROW [EC:2.7.11.1] synonym: "phosphorylase b kinase kinase activity" BROAD [EC:2.7.11.1] synonym: "PKA" RELATED [EC:2.7.11.1] synonym: "PKC" RELATED [EC:2.7.11.1] synonym: "protein glutamyl kinase activity" NARROW [EC:2.7.11.1] synonym: "protein kinase (phosphorylating) activity" NARROW [EC:2.7.11.1] synonym: "protein kinase A activity" BROAD [EC:2.7.11.1] synonym: "protein kinase p58 activity" NARROW [EC:2.7.11.1] synonym: "protein phosphokinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein serine-threonine kinase activity" EXACT [EC:2.7.11.1] synonym: "protein-aspartyl kinase activity" RELATED [EC:2.7.11.1] synonym: "protein-cysteine kinase activity" NARROW [EC:2.7.11.1] synonym: "protein-serine kinase activity" NARROW [EC:2.7.11.1] synonym: "Prp4 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf kinase activity" NARROW [EC:2.7.11.1] synonym: "Raf-1" RELATED [EC:2.7.11.1] synonym: "ribosomal protein S6 kinase II activity" NARROW [EC:2.7.11.1] synonym: "ribosomal S6 protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine kinase activity" NARROW [EC:2.7.11.1] synonym: "serine protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine(threonine) protein kinase activity" EXACT [EC:2.7.11.1] synonym: "serine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "serine/threonine protein kinase activity" EXACT [EC:2.7.11.1] synonym: "STK32" RELATED [EC:2.7.11.1] synonym: "T-antigen kinase activity" NARROW [EC:2.7.11.1] synonym: "threonine-specific protein kinase activity" NARROW [EC:2.7.11.1] synonym: "twitchin kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee 1-like kinase activity" NARROW [EC:2.7.11.1] synonym: "Wee-kinase activity" NARROW [EC:2.7.11.1] synonym: "WEE1Hu" RELATED [EC:2.7.11.1] xref: EC:2.7.11 xref: EC:2.7.11.- xref: MetaCyc:PROTEIN-KINASE-RXN xref: Reactome:4028 "protein serine/threonine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004675 name: transmembrane receptor protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + receptor-protein serine/threonine = ADP + receptor-protein serine/threonine phosphate." [EC:2.7.11.30] synonym: "activin receptor kinase activity" NARROW [EC:2.7.11.30] synonym: "ATP:receptor-protein phosphotransferase activity" EXACT [EC:2.7.11.30] synonym: "receptor protein serine/threonine kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor serine/threonine protein kinase activity" EXACT [EC:2.7.11.30] synonym: "receptor type I serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "receptor type II serine/threonine protein kinase activity" NARROW [EC:2.7.11.30] synonym: "STK13" RELATED [EC:2.7.11.30] synonym: "TGF-beta kinase activity" NARROW [EC:2.7.11.30] xref: EC:2.7.11.- xref: MetaCyc:2.7.11.30-RXN xref: Reactome:11160 "transmembrane receptor protein serine/threonine kinase activity" is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004676 name: 3-phosphoinositide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a 3-phosphoinositide." [GOC:mah] xref: EC:2.7.11.- xref: Reactome:13519 "3-phosphoinositide-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004677 name: DNA-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, requiring the presence of DNA." [GOC:mah] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004679 name: AMP-activated protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of AMP." [GOC:mah] synonym: "5'-AMP-activated protein kinase activity" EXACT [] synonym: "SNF1A/AMP-activated protein kinase activity" NARROW [] xref: EC:2.7.11.- xref: Reactome:13522 "AMP-activated protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004680 name: casein kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:2.7.11.- is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004681 name: casein kinase I activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:2.7.11.- is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004682 name: protein kinase CK2 activity namespace: molecular_function alt_id: GO:0008604 def: "OBSOLETE. Catalysis of the reaction: casein + ATP = phosphocasein + ADP." [EC:2.7.11.1] comment: This term was made obsolete because it represents a gene product. synonym: "casein kinase II activity" RELATED [] synonym: "casein kinase II, catalytic activity" EXACT [] synonym: "protein kinase CK2, intrinsic catalyst activity" EXACT [] is_obsolete: true replaced_by: GO:0004674 [Term] id: GO:0004683 name: calmodulin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0004684 alt_id: GO:0004685 alt_id: GO:0004688 def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium-bound calmodulin." [GOC:mah, PMID:11264466] subset: gosubset_prok synonym: "ATP:caldesmon O-phosphotransferase activity" NARROW [EC:2.7.11.17] synonym: "ATP:protein phosphotransferase (Ca2+/calmodulin-dependent) activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent microtubule-associated protein 2 kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase 1 activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase II activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase IV activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/calmodulin-dependent protein kinase kinase beta activity" NARROW [EC:2.7.11.17] synonym: "Ca2+/CaM-dependent kinase activity" EXACT [] synonym: "calcium- and calmodulin-dependent protein kinase activity" EXACT [] synonym: "calcium/calmodulin-dependent protein kinase activity" EXACT [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase type II activity" NARROW [EC:2.7.11.17] synonym: "caldesmon kinase (phosphorylating) activity" NARROW [EC:2.7.11.17] synonym: "calmodulin regulated protein kinase activity" EXACT [] synonym: "calmodulin-dependent kinase II activity" NARROW [EC:2.7.11.17] synonym: "calmodulin-dependent protein kinase I activity" NARROW [] synonym: "CaM kinase activity" EXACT [EC:2.7.11.17] synonym: "CaM kinase II activity" NARROW [EC:2.7.11.17] synonym: "CAM PKII" RELATED [EC:2.7.11.17] synonym: "CaM-regulated serine/threonine kinase activity" EXACT [EC:2.7.11.17] synonym: "CaMKI" RELATED [EC:2.7.11.17] synonym: "CaMKII" RELATED [EC:2.7.11.17] synonym: "CaMKIV" RELATED [EC:2.7.11.17] synonym: "CaMKKalpha" RELATED [EC:2.7.11.17] synonym: "CaMKKbeta" RELATED [EC:2.7.11.17] synonym: "microtubule-associated protein 2 kinase activity" RELATED [EC:2.7.11.17] synonym: "multifunctional calcium- and calmodulin-regulated protein kinase activity" RELATED [] synonym: "multifunctional calcium/calmodulin regulated protein kinase activity" RELATED [] synonym: "STK20" RELATED [EC:2.7.11.17] xref: EC:2.7.11.17 xref: MetaCyc:2.7.11.17-RXN xref: Reactome:4026 "calmodulin-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004686 name: elongation factor-2 kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of eukaryotic elongation factor-2." [GOC:jl, PMID:11904175] synonym: "ATP:elongation factor 2 phosphotransferase activity" EXACT [EC:2.7.11.20] synonym: "Ca/CaM-kinase III activity" EXACT [EC:2.7.11.20] synonym: "calmodulin-dependent protein kinase III activity" EXACT [EC:2.7.11.20] synonym: "CaM kinase III activity" EXACT [EC:2.7.11.20] synonym: "eEF-2 kinase activity" EXACT [] synonym: "eEF2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eEF2K" RELATED [EC:2.7.11.20] synonym: "EF2K" RELATED [EC:2.7.11.20] synonym: "elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "eukaryotic elongation factor 2 kinase activity" EXACT [EC:2.7.11.20] synonym: "STK19" RELATED [EC:2.7.11.20] xref: EC:2.7.11.20 is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004687 name: myosin light chain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (myosin-light-chain) = ADP + (myosin-light-chain) phosphate." [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase" BROAD [EC:2.7.11.18] synonym: "ATP:myosin-light-chain O-phosphotransferase activity" EXACT [EC:2.7.11.18] synonym: "calcium/calmodulin-dependent myosin light chain kinase activity" EXACT [EC:2.7.11.18] synonym: "MLCK" RELATED [EC:2.7.11.18] synonym: "MLCkase activity" EXACT [EC:2.7.11.18] synonym: "myosin kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light chain protein kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase" BROAD [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating)" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase (phosphorylating) activity" EXACT [EC:2.7.11.18] synonym: "myosin light-chain kinase activity" EXACT [EC:2.7.11.18] synonym: "myosin-light-chain kinase activity" EXACT [] synonym: "smooth-muscle-myosin-light-chain kinase activity" NARROW [EC:2.7.11.18] synonym: "STK18" RELATED [EC:2.7.11.18] xref: EC:2.7.11.18 xref: MetaCyc:2.7.11.18-RXN xref: Reactome:13543 "myosin light chain kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004689 name: phosphorylase kinase activity namespace: molecular_function alt_id: GO:0008606 def: "Catalysis of the reaction: 4 ATP + 2 phosphorylase b = 4 ADP + phosphorylase a." [EC:2.7.11.19] subset: gosubset_prok synonym: "ATP:phosphorylase-b phosphotransferase activity" EXACT [EC:2.7.11.19] synonym: "dephosphophosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "glycogen phosphorylase kinase activity" EXACT [EC:2.7.11.19] synonym: "PHK" RELATED [EC:2.7.11.19] synonym: "phosphorylase b kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase B kinase activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase (phosphorylating) activity" EXACT [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic catalyst activity" EXACT [] synonym: "STK17" RELATED [EC:2.7.11.19] xref: EC:2.7.11.19 xref: MetaCyc:2.7.11.19-RXN xref: Reactome:13545 "phosphorylase kinase activity" is_a: GO:0004683 ! calmodulin-dependent protein kinase activity [Term] id: GO:0004690 name: cyclic nucleotide-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of a cyclic nucleotide." [GOC:mah] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004691 name: cAMP-dependent protein kinase activity namespace: molecular_function alt_id: GO:0008602 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cAMP." [EC:2.7.11.11] synonym: "3',5' cAMP-dependent protein kinase activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase activity" EXACT [] synonym: "AMPK" RELATED [EC:2.7.11.11] synonym: "ATP:protein phosphotransferase (cAMP-dependent) activity" EXACT [EC:2.7.11.11] synonym: "cAMP-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "cyclic AMP-dependent protein kinase activity" EXACT [] synonym: "PKA" RELATED [EC:2.7.11.11] synonym: "PKA C" RELATED [EC:2.7.11.11] synonym: "protein kinase A activity" BROAD [EC:2.7.11.11] synonym: "STK22" RELATED [EC:2.7.11.11] xref: EC:2.7.11.11 xref: MetaCyc:2.7.11.11-RXN xref: Reactome:13562 "cAMP-dependent protein kinase activity" is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004692 name: cGMP-dependent protein kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the presence of cGMP." [GOC:mah] synonym: "3':5'-cyclic GMP-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "ATP:protein phosphotransferase (cGMP-dependent) activity" EXACT [EC:2.7.11.12] synonym: "cGMP-dependent protein kinase ibeta activity" EXACT [EC:2.7.11.12] synonym: "guanosine 3':5'-cyclic monophosphate-dependent protein kinase activity" EXACT [EC:2.7.11.12] synonym: "PKG" RELATED [EC:2.7.11.12] synonym: "PKG 1alpha" RELATED [EC:2.7.11.12] synonym: "PKG 1beta" RELATED [EC:2.7.11.12] synonym: "PKG II" RELATED [EC:2.7.11.12] synonym: "STK23" RELATED [EC:2.7.11.12] xref: EC:2.7.11.12 xref: MetaCyc:2.7.11.12-RXN is_a: GO:0004690 ! cyclic nucleotide-dependent protein kinase activity [Term] id: GO:0004693 name: cyclin-dependent protein kinase activity namespace: molecular_function alt_id: GO:0016537 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein; dependent on the binding of a regulatory cyclin subunit and full activity requires stimulatory phosphorylation by a CDK-activating kinase (CAK)." [GOC:rn, PMID:7877684, PMID:9841670] synonym: "ATP:cyclin phosphotransferase activity" EXACT [EC:2.7.11.22] synonym: "cdc2 kinase activity" NARROW [EC:2.7.11.22] synonym: "CDK" RELATED [EC:2.7.11.22] synonym: "CDK activity" EXACT [] synonym: "CDK, catalytic subunit activity" EXACT [] synonym: "cdk-activating kinase activity" EXACT [EC:2.7.11.22] synonym: "Cdk-activating protein kinase activity" EXACT [EC:2.7.11.22] synonym: "cyclin D-cdk6 kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin D-dependent kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin E kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-A associated kinase activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase 6 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase activity" BROAD [EC:2.7.11.22] synonym: "cyclin-dependent kinase-2 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent kinase-4 activity" NARROW [EC:2.7.11.22] synonym: "cyclin-dependent protein kinase, intrinsic catalyst activity" EXACT [] synonym: "D-type cyclin kinase activity" NARROW [EC:2.7.11.22] synonym: "neuronal cdc2-like kinase activity" NARROW [EC:2.7.11.22] xref: EC:2.7.11.22 xref: MetaCyc:2.7.11.22-RXN xref: Reactome:13565 "cyclin-dependent protein kinase activity" is_a: GO:0004674 ! protein serine/threonine kinase activity relationship: part_of GO:0007049 ! cell cycle [Term] id: GO:0004694 name: eukaryotic translation initiation factor 2alpha kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of the alpha subunit of eukaryotic translation initiation factor 2 (EIF2)." [GOC:mah, InterPro:IPR015516] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004695 name: galactosyltransferase-associated kinase activity namespace: molecular_function xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004696 name: glycogen synthase kinase 3 activity namespace: molecular_function xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004697 name: protein kinase C activity namespace: molecular_function alt_id: GO:0004701 def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol." [EC:2.7.11.13] synonym: "ATP:protein phosphotransferase (diacylglycerol-dependent) activity" EXACT [EC:2.7.11.13] synonym: "cPKC" RELATED [EC:2.7.11.13] synonym: "cPKCalpha" RELATED [EC:2.7.11.13] synonym: "cPKCbeta" RELATED [EC:2.7.11.13] synonym: "cPKCgamma" RELATED [EC:2.7.11.13] synonym: "diacylglycerol-activated phospholipid-dependent PKC activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C activity" EXACT [] synonym: "nPKC" RELATED [EC:2.7.11.13] synonym: "nPKCdelta" RELATED [EC:2.7.11.13] synonym: "nPKCepsilon" RELATED [EC:2.7.11.13] synonym: "nPKCeta" RELATED [EC:2.7.11.13] synonym: "nPKCtheta" RELATED [EC:2.7.11.13] synonym: "PKC" RELATED [EC:2.7.11.13] synonym: "PKC activity" EXACT [] synonym: "Pkc1p" RELATED [EC:2.7.11.13] synonym: "PKCalpha" RELATED [EC:2.7.11.13] synonym: "PKCbeta" RELATED [EC:2.7.11.13] synonym: "PKCdelta" RELATED [EC:2.7.11.13] synonym: "PKCepsilon" RELATED [EC:2.7.11.13] synonym: "PKCgamma" RELATED [EC:2.7.11.13] synonym: "PKCzeta" RELATED [EC:2.7.11.13] synonym: "protein kinase Cepsilon activity" NARROW [EC:2.7.11.13] synonym: "STK24" RELATED [EC:2.7.11.13] xref: EC:2.7.11.13 xref: MetaCyc:2.7.11.13-RXN xref: Reactome:13569 "protein kinase C activity" is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004698 name: calcium-dependent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol and calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-dependent PKC activity" EXACT [] synonym: "conventional protein kinase C activity" EXACT [PMID:9601053] xref: EC:2.7.11.- xref: Reactome:13572 "calcium-dependent protein kinase C activity" is_a: GO:0004697 ! protein kinase C activity is_a: GO:0009931 ! calcium-dependent protein serine/threonine kinase activity [Term] id: GO:0004699 name: calcium-independent protein kinase C activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein = ADP + a phosphoprotein, with a requirement for diacylglycerol but not calcium." [EC:2.7.11.13, GOC:mah] synonym: "calcium-independent PKC activity" EXACT [] synonym: "novel protein kinase C activity" EXACT [PMID:9601053] is_a: GO:0004697 ! protein kinase C activity [Term] id: GO:0004702 name: receptor signaling protein serine/threonine kinase activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine kinase activity" EXACT [] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004703 name: G-protein coupled receptor kinase activity namespace: molecular_function alt_id: GO:0004678 def: "Catalysis of the phosphorylation of a G-protein coupled receptor, thereby modulating its activity." [GOC:dph] synonym: "ATP:G-protein-coupled receptor phosphotransferase activity" EXACT [EC:2.7.11.16] synonym: "G protein coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "G protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor kinase activity" EXACT [EC:2.7.11.16] synonym: "G-protein-coupled receptor phosphorylating protein kinase activity" EXACT [] synonym: "GPCR kinase activity" EXACT [EC:2.7.11.16] synonym: "GPCR phosphorylating protein kinase activity" EXACT [] synonym: "GPCRK" RELATED [EC:2.7.11.16] synonym: "GRK4" RELATED [EC:2.7.11.16] synonym: "GRK5" RELATED [EC:2.7.11.16] synonym: "GRK6" RELATED [EC:2.7.11.16] synonym: "STK16" RELATED [EC:2.7.11.16] xref: EC:2.7.11.16 is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004704 name: NF-kappaB-inducing kinase activity namespace: molecular_function synonym: "NIK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004705 name: JUN kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of members of the JUN family, a gene family that encodes nuclear transcription factors." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "c-Jun N-terminal kinase activity" NARROW [] synonym: "JNK" EXACT [] synonym: "JNK3alpha1" RELATED [] synonym: "SAPK1" NARROW [] xref: EC:2.7.11.- xref: MetaCyc:2.7.11.24-RXN xref: Reactome:14136 "JUN kinase activity" is_a: GO:0016909 ! SAP kinase activity relationship: part_of GO:0007258 ! JUN phosphorylation [Term] id: GO:0004706 name: JUN kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of JUN kinase kinases (JNKKs)." [GOC:bf] synonym: "JNK kinase kinase activity" RELATED [] synonym: "JNKKK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0004707 name: MAP kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of proteins. Mitogen-activated protein kinase; a family of protein kinases that perform a crucial step in relaying signals from the plasma membrane to the nucleus. They are activated by a wide range of proliferation- or differentiation-inducing signals; activation is strong with agonists such as polypeptide growth factors and tumor-promoting phorbol esters, but weak (in most cell backgrounds) by stress stimuli." [GOC:ma, ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKK-activated) activity" EXACT [EC:2.7.11.24] synonym: "Dp38" RELATED [EC:2.7.11.24] synonym: "ERK" RELATED [EC:2.7.11.24] synonym: "extracellular signal-regulated kinase activity" NARROW [EC:2.7.11.24] synonym: "LeMPK3" RELATED [EC:2.7.11.24] synonym: "MAP-2 kinase activity" NARROW [EC:2.7.11.24] synonym: "MAPK" RELATED [EC:2.7.11.24] synonym: "MBP kinase I activity" NARROW [EC:2.7.11.24] synonym: "MBP kinase II activity" NARROW [EC:2.7.11.24] synonym: "mitogen activated kinase activity" EXACT [] synonym: "mitogen-activated protein kinase activity" EXACT [EC:2.7.11.24] synonym: "myelin basic protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p38-2" RELATED [EC:2.7.11.24] synonym: "p38delta" RELATED [EC:2.7.11.24] synonym: "p42 mitogen-activated protein kinase activity" NARROW [EC:2.7.11.24] synonym: "p42mapk" RELATED [EC:2.7.11.24] synonym: "p44mpk" RELATED [EC:2.7.11.24] synonym: "PMK-1" RELATED [EC:2.7.11.24] synonym: "PMK-2" RELATED [EC:2.7.11.24] synonym: "PMK-3" RELATED [EC:2.7.11.24] synonym: "pp42" RELATED [EC:2.7.11.24] synonym: "pp44mapk" RELATED [EC:2.7.11.24] synonym: "STK26" RELATED [EC:2.7.11.24] xref: EC:2.7.11.24 xref: MetaCyc:2.7.11.24-RXN xref: Reactome:4049 "MAP kinase activity" is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004708 name: MAP kinase kinase activity namespace: molecular_function def: "Catalysis of the concomitant phosphorylation of threonine (T) and tyrosine (Y) residues in a Thr-Glu-Tyr (TEY) thiolester sequence in MAP kinases. It is a dual-specificity mitogen-activated protein kinase kinase and requires activation by the serine/threonine kinase, MAP kinase kinase kinase." [ISBN:0198547684] synonym: "ATP:protein phosphotransferase (MAPKKK-activated) activity" EXACT [EC:2.7.12.2] synonym: "ERK activator kinase activity" EXACT [] synonym: "MAP kinase kinase 4 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase kinase 7 activity" NARROW [EC:2.7.12.2] synonym: "MAP kinase or ERK kinase activity" RELATED [EC:2.7.12.2] synonym: "MAP2K" RELATED [EC:2.7.12.2] synonym: "MAPKK" RELATED [EC:2.7.12.2] synonym: "MAPKK activity" EXACT [] synonym: "MAPKK1" RELATED [EC:2.7.12.2] synonym: "MEK activity" BROAD [] synonym: "MEK1" RELATED [EC:2.7.12.2] synonym: "MEK2" RELATED [EC:2.7.12.2] synonym: "mitogen-activated protein kinase kinase activity" EXACT [EC:2.7.12.2] synonym: "MKK" RELATED [EC:2.7.12.2] synonym: "MKK2" RELATED [EC:2.7.12.2] synonym: "MKK4" RELATED [EC:2.7.12.2] synonym: "MKK6" RELATED [EC:2.7.12.2] synonym: "MKK7" RELATED [EC:2.7.12.2] synonym: "STK27" RELATED [EC:2.7.12.2] xref: EC:2.7.11.- xref: MetaCyc:2.7.12.2-RXN xref: Reactome:14146 "MAP kinase kinase activity" is_a: GO:0004712 ! protein serine/threonine/tyrosine kinase activity [Term] id: GO:0004709 name: MAP kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation and activation of MAP kinase kinases; each MAP kinase kinase can be phosphorylated by any of several MAP kinase kinase kinases." [PMID:9561267] synonym: "ATP:protein phosphotransferase (MAPKKKK-activated) activity" EXACT [EC:2.7.11.25] synonym: "cMos" RELATED [EC:2.7.11.25] synonym: "cRaf" RELATED [EC:2.7.11.25] synonym: "MAP3K" RELATED [EC:2.7.11.25] synonym: "MAPKKK activity" EXACT [EC:2.7.11.25] synonym: "MEK kinase activity" EXACT [EC:2.7.11.25] synonym: "MEKK" RELATED [EC:2.7.11.25] synonym: "MEKK1" RELATED [EC:2.7.11.25] synonym: "MEKK2" RELATED [EC:2.7.11.25] synonym: "MEKK3" RELATED [EC:2.7.11.25] synonym: "Mil/Raf" RELATED [EC:2.7.11.25] synonym: "mitogen-activated protein kinase kinase kinase activity" EXACT [EC:2.7.11.25] synonym: "MLK-like mitogen-activated protein triple kinase activity" NARROW [EC:2.7.11.25] synonym: "MLTK" RELATED [EC:2.7.11.25] synonym: "MLTKa" RELATED [EC:2.7.11.25] synonym: "MLTKb" RELATED [EC:2.7.11.25] synonym: "REKS" RELATED [EC:2.7.11.25] synonym: "STK28" RELATED [EC:2.7.11.25] xref: EC:2.7.11.25 xref: MetaCyc:2.7.11.25-RXN xref: Reactome:14141 "MAP kinase kinase kinase activity" is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0004710 name: MAP/ERK kinase kinase activity namespace: molecular_function synonym: "MEKK activity" EXACT [] xref: EC:2.7.11.- xref: MetaCyc:2.7.11.25-RXN is_a: GO:0004709 ! MAP kinase kinase kinase activity [Term] id: GO:0004711 name: ribosomal protein S6 kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of ribosomal protein S6." [GOC:mah, PMID:9822608] xref: EC:2.7.11.- is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0004712 name: protein serine/threonine/tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine/tyrosine = ADP + protein serine/threonine/tyrosine phosphate." [GOC:mah] subset: gosubset_prok synonym: "ADK1" RELATED [EC:2.7.12.1] synonym: "Arabidopsis dual specificity kinase 1 activity" NARROW [EC:2.7.12.1] synonym: "ATP:protein phosphotransferase (Ser/Thr- and Tyr-phosphorylating) activity" EXACT [EC:2.7.12.1] synonym: "CLK1" RELATED [EC:2.7.12.1] synonym: "dDYRK2" RELATED [EC:2.7.12.1] synonym: "dual-specificity kinase activity" BROAD [EC:2.7.12.1] synonym: "dual-specificity protein kinase" BROAD [] synonym: "Mps1p" RELATED [EC:2.7.12.1] synonym: "protein threonine/tyrosine kinase activity" NARROW [] xref: EC:2.7.112.1 xref: Reactome:14147 "protein serine/threonine/tyrosine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004713 name: protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein tyrosine = ADP + protein tyrosine phosphate." [EC:2.7.10] subset: gosubset_prok synonym: "protein-tyrosine kinase activity" EXACT [] xref: EC:2.7.10 xref: MetaCyc:2.7.10.1-RXN xref: MetaCyc:2.7.10.2-RXN xref: Reactome:11065 "protein tyrosine kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004714 name: transmembrane receptor protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate, to initiate a change in cell activity." [EC:2.7.10.1, GOC:mah] subset: gosubset_prok synonym: "anaplastic lymphoma kinase activity" NARROW [EC:2.7.10.1] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (receptor-type) activity" EXACT [EC:2.7.10.1] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.1] synonym: "Drosophila Eph kinase activity" NARROW [EC:2.7.10.1] synonym: "ephrin-B3 receptor tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "insulin receptor protein-tyrosine kinase activity" NARROW [EC:2.7.10.1] synonym: "neurite outgrowth regulating kinase activity" NARROW [EC:2.7.10.1] synonym: "neurotrophin TRK receptor activity" RELATED [] synonym: "neurotrophin TRKA receptor activity" RELATED [] synonym: "neurotrophin TRKB receptor activity" RELATED [] synonym: "neurotrophin TRKC receptor activity" RELATED [] synonym: "novel oncogene with kinase-domain activity" NARROW [EC:2.7.10.1] synonym: "receptor protein tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "receptor protein-tyrosine kinase activity" EXACT [EC:2.7.10.1] synonym: "sevenless receptor activity" RELATED [] xref: EC:2.7.10.1 xref: MetaCyc:2.7.10.1-RXN xref: Reactome:11064 "transmembrane receptor protein tyrosine kinase activity" is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0004715 name: non-membrane spanning protein tyrosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate." [EC:2.7.10.2] synonym: "ATP:protein-L-tyrosine O-phosphotransferase (non-specific) activity" EXACT [EC:2.7.10.2] synonym: "ATP:protein-tyrosine O-phosphotransferase activity" BROAD [EC:2.7.10.2] synonym: "Bruton's tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "cytoplasmic protein tyrosine kinase activity" NARROW [EC:2.7.10.2] synonym: "focal adhesion kinase activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 1 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 2 activity" NARROW [EC:2.7.10.2] synonym: "janus kinase 3 activity" NARROW [EC:2.7.10.2] synonym: "non-specific protein-tyrosine kinase activity" EXACT [EC:2.7.10.2] synonym: "p60c-src protein tyrosine kinase activity" NARROW [EC:2.7.10.2] xref: EC:2.7.10.2 xref: MetaCyc:2.7.10.1-RXN xref: MetaCyc:2.7.10.2-RXN is_a: GO:0004713 ! protein tyrosine kinase activity [Term] id: GO:0004716 name: receptor signaling protein tyrosine kinase activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase activity" EXACT [] xref: EC:2.7.10.- is_a: GO:0004713 ! protein tyrosine kinase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004717 name: focal adhesion kinase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product, and because the gene was named after its location of action rather than after its molecular function. synonym: "FAK" EXACT [] is_obsolete: true replaced_by: GO:0004713 [Term] id: GO:0004718 name: Janus kinase activity namespace: molecular_function synonym: "JAK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004716 ! receptor signaling protein tyrosine kinase activity [Term] id: GO:0004719 name: protein-L-isoaspartate (D-aspartate) O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-beta-aspartate = S-adenosyl-L-homocysteine + protein L-beta-aspartate methyl ester." [EC:2.1.1.77] subset: gosubset_prok synonym: "D-aspartyl/L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-aspartyl/L-isoaspartyl protein methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "L-isoaspartyl/D-aspartyl protein carboxyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein (D-aspartate) methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein D-aspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartate methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein L-isoaspartyl methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein O-methyltransferase (L-isoaspartate)" EXACT [EC:2.1.1.77] synonym: "protein-beta-aspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "protein-L-isoaspartate(D-aspartate) O-methyltransferase activity" EXACT [EC:2.1.1.77] synonym: "S-adenosyl-L-methionine:protein-L-isoaspartate O-methyltransferase activity" EXACT [EC:2.1.1.77] xref: EC:2.1.1.77 xref: MetaCyc:2.1.1.77-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0004720 name: protein-lysine 6-oxidase activity namespace: molecular_function alt_id: GO:0018056 def: "Catalysis of the reaction: peptidyl-L-lysyl-peptide + H2O + O2 = peptidyl-allysyl-peptide + NH3 + H2O2." [EC:1.4.3.13] synonym: "lysyl oxidase activity" EXACT [EC:1.4.3.13] synonym: "protein-L-lysine:oxygen 6-oxidoreductase (deaminating)" EXACT [EC:1.4.3.13] xref: EC:1.4.3.13 xref: MetaCyc:PROTEIN-LYSINE-6-OXIDASE-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0004721 name: phosphoprotein phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: a phosphoprotein + H2O = a protein + phosphate. Together with protein kinases, these enzymes control the state of phosphorylation of cell proteins and thereby provide an important mechanism for regulating cellular activity." [EC:3.1.3.16, ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_yeast subset: gosubset_prok synonym: "phosphoprotein phosphohydrolase activity" EXACT [EC:3.1.3.16] synonym: "protein phosphatase activity" EXACT [] synonym: "protein phosphatase-1 activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2A activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2B activity" NARROW [EC:3.1.3.16] synonym: "protein phosphatase-2C activity" NARROW [EC:3.1.3.16] xref: EC:3.1.3.16 xref: MetaCyc:3.1.3.16-RXN xref: Reactome:1887 "phosphoprotein phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004722 name: protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0000158 alt_id: GO:0000163 alt_id: GO:0008598 alt_id: GO:0008600 alt_id: GO:0015071 alt_id: GO:0030357 alt_id: GO:0030358 alt_id: GO:0030360 alt_id: GO:0030361 def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate." [GOC:bf] subset: gosubset_prok synonym: "3-hydroxy 3-methylglutaryl coenzymeA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "Aspergillus awamori acid protein phosphatase" NARROW [EC:3.1.3.16] synonym: "BCKDH phosphatase" NARROW [EC:3.1.3.16] synonym: "branched-chain alpha-keto acid dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "calcineurin" NARROW [] synonym: "casein phosphatase" NARROW [EC:3.1.3.16] synonym: "HMG-CoA reductase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphatase 2A" NARROW [EC:3.1.3.16] synonym: "phosphatase 2B" NARROW [EC:3.1.3.16] synonym: "phosphatase C-II" NARROW [EC:3.1.3.16] synonym: "phosphatase H-II" NARROW [EC:3.1.3.16] synonym: "phosphatase I" NARROW [EC:3.1.3.16] synonym: "phosphatase IB" NARROW [EC:3.1.3.16] synonym: "phosphatase II" NARROW [EC:3.1.3.16] synonym: "phosphatase III" NARROW [EC:3.1.3.16] synonym: "phosphatase IV" NARROW [EC:3.1.3.16] synonym: "phosphatase SP" NARROW [EC:3.1.3.16] synonym: "phosphopyruvate dehydrogenase phosphatase" NARROW [EC:3.1.3.16] synonym: "phosphospectrin phosphatase" NARROW [EC:3.1.3.16] synonym: "polycation modulated (PCM-) phosphatase" NARROW [EC:3.1.3.16] synonym: "protein D phosphatase" NARROW [EC:3.1.3.16] synonym: "protein phosphatase type 1 activity" NARROW [] synonym: "protein phosphatase type 1, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2A activity" NARROW [] synonym: "protein phosphatase type 2A, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2B activity" NARROW [] synonym: "protein phosphatase type 2B, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase type 2C activity" NARROW [] synonym: "protein phosphatase type 4 activity" NARROW [] synonym: "protein phosphatase type 4, intrinsic catalyst activity" NARROW [] synonym: "protein phosphatase X" NARROW [] synonym: "serine/threonine specific protein phosphatase activity" EXACT [] xref: MetaCyc:3.1.3.16-RXN xref: Reactome:14173 "protein serine/threonine phosphatase activity" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004723 name: calcium-dependent protein serine/threonine phosphatase activity namespace: molecular_function alt_id: GO:0008596 def: "Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium ions." [EC:3.1.3.16, GOC:mah] synonym: "calcineurin" NARROW [] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic catalyst activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004724 name: magnesium-dependent protein serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the removal of a serine- or threonine-bound phosphate group from a protein; action dependent on magnesium." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0004725 name: protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate." [EC:3.1.3.48] subset: gosubset_prok synonym: "[phosphotyrosine]protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphoprotein phosphatase (phosphotyrosine) activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine histone phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosine protein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "phosphotyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PPT-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein phosphotyrosine phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "protein-tyrosine-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.48] synonym: "PTP-phosphatase activity" EXACT [EC:3.1.3.48] synonym: "PTPase activity" EXACT [EC:3.1.3.48] synonym: "tyrosine O-phosphate phosphatase activity" EXACT [EC:3.1.3.48] synonym: "tyrosylprotein phosphatase activity" EXACT [EC:3.1.3.48] xref: EC:3.1.3.48 xref: MetaCyc:PROTEIN-TYROSINE-PHOSPHATASE-RXN xref: Reactome:11061 "protein tyrosine phosphatase activity" is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004726 name: non-membrane spanning protein tyrosine phosphatase activity namespace: molecular_function subset: gosubset_prok xref: Reactome:14178 "non-membrane spanning protein tyrosine phosphatase activity" is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004727 name: prenylated protein tyrosine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: prenylated-protein tyrosine phosphate + H2O = prenylated-protein tyrosine + phosphate." [EC:3.1.3.48] is_a: GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0004728 name: receptor signaling protein tyrosine phosphatase activity namespace: molecular_function synonym: "receptor signalling protein tyrosine phosphatase activity" EXACT [] is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0004729 name: oxygen-dependent protoporphyrinogen oxidase activity namespace: molecular_function def: "Catalysis of the reaction: protoporphyrinogen-IX + O2 = protoporphyrin-IX + H2O2." [EC:1.3.3.4] subset: gosubset_prok synonym: "protoporphyrinogen-IX:oxygen oxidoreductase activity" EXACT [EC:1.3.3.4] xref: EC:1.3.3.4 xref: MetaCyc:PROTOPORGENOXI-RXN xref: Reactome:14184 "oxygen-dependent protoporphyrinogen oxidase activity" is_a: GO:0016634 ! oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor is_a: GO:0070818 ! protoporphyrinogen oxidase activity [Term] id: GO:0004730 name: pseudouridylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: uracil + D-ribose 5-phosphate = pseudouridine 5'-phosphate + H2O." [EC:4.2.1.70] comment: Note that this term should not be confused with 'pseudouridine synthase activity ; GO:0009982', which refers to the intramolecular isomerization of uridine to pseudouridine. subset: gosubset_prok synonym: "5-ribosyluracil 5-phosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridine monophosphate synthase activity" EXACT [] synonym: "pseudouridine monophosphate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylate synthetase activity" EXACT [EC:4.2.1.70] synonym: "pseudouridylic acid synthetase activity" EXACT [EC:4.2.1.70] synonym: "psiUMP synthetase activity" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate)" EXACT [EC:4.2.1.70] synonym: "uracil hydro-lyase (adding D-ribose 5-phosphate; pseudouridine-5'-phosphate-forming)" EXACT [EC:4.2.1.70] synonym: "uracil hydrolyase activity" RELATED [EC:4.2.1.70] xref: EC:4.2.1.70 xref: MetaCyc:PSEUDOURIDYLATE-SYNTHASE-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004731 name: purine-nucleoside phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate." [EC:2.4.2.1] subset: gosubset_prok synonym: "inosine phosphorylase activity" NARROW [EC:2.4.2.1] synonym: "inosine-guanosine phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "PNPase activity" EXACT [EC:2.4.2.1] synonym: "PUNPI" RELATED [EC:2.4.2.1] synonym: "PUNPII" RELATED [EC:2.4.2.1] synonym: "purine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine deoxyribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine nucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine ribonucleoside phosphorylase activity" EXACT [EC:2.4.2.1] synonym: "purine-nucleoside:phosphate ribosyltransferase activity" EXACT [EC:2.4.2.1] xref: EC:2.4.2.1 xref: MetaCyc:PNP-RXN xref: Reactome:14201 "purine-nucleoside phosphorylase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004732 name: pyridoxal oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxal + H2O + O2 = 4-pyridoxate + H2O2." [EC:1.2.3.8] synonym: "pyridoxal:oxygen 4-oxidoreductase activity" EXACT [EC:1.2.3.8] xref: EC:1.2.3.8 xref: MetaCyc:PYRIDOXAL-OXIDASE-RXN is_a: GO:0016623 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor [Term] id: GO:0004733 name: pyridoxamine-phosphate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: pyridoxamine 5'-phosphate + H2O + O2 = pyridoxal 5'-phosphate + NH3 + H2O2." [EC:1.4.3.5] subset: gosubset_prok synonym: "PdxH" RELATED [EC:1.4.3.5] synonym: "PMP oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxal 5'-phosphate synthase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxamine-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxaminephosphate oxidase (EC 1.4.3.5: deaminating)" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine) 5'-phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxine (pyridoxamine)phosphate oxidase activity" EXACT [EC:1.4.3.5] synonym: "pyridoxol-5'-phosphate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.5] xref: EC:1.4.3.5 xref: MetaCyc:PMPOXI-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0004734 name: pyrimidodiazepine synthase activity namespace: molecular_function def: "Catalysis of the reaction: a pyrimidodiazepine + oxidized glutathione = 6-pyruvoyltetrahydropterin + 2 glutathione." [EC:1.5.4.1] synonym: "PDA synthase activity" EXACT [EC:1.5.4.1] synonym: "pyrimidodiazepine:glutathione-disulfide oxidoreductase (ring-opening, cyclizing)" EXACT [EC:1.5.4.1] xref: EC:1.5.4.1 xref: MetaCyc:1.5.4.1-RXN is_a: GO:0016648 ! oxidoreductase activity, acting on the CH-NH group of donors, disulfide as acceptor [Term] id: GO:0004735 name: pyrroline-5-carboxylate reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+." [EC:1.5.1.2] subset: gosubset_prok synonym: "1-pyrroline-5-carboxylate reductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline oxidase activity" EXACT [EC:1.5.1.2] synonym: "L-proline-NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "L-proline:NAD(P)+ 5-oxidoreductase activity" EXACT [EC:1.5.1.2] synonym: "NADPH-L-delta1-pyrroline carboxylic acid reductase activity" EXACT [EC:1.5.1.2] synonym: "P5CR activity" EXACT [EC:1.5.1.2] xref: EC:1.5.1.2 xref: MetaCyc:PYRROLINECARBREDUCT-RXN xref: Reactome:14208 "pyrroline-5-carboxylate reductase activity" is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004736 name: pyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate + HCO3- = ADP + phosphate + oxaloacetate." [EC:6.4.1.1] subset: gosubset_prok synonym: "pyruvate:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.4.1.1] synonym: "pyruvic carboxylase activity" EXACT [EC:6.4.1.1] xref: EC:6.4.1.1 xref: MetaCyc:PYRUVATE-CARBOXYLASE-RXN xref: Reactome:14209 "pyruvate carboxylase activity" is_a: GO:0016885 ! ligase activity, forming carbon-carbon bonds [Term] id: GO:0004737 name: pyruvate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: a 2-oxo acid = an aldehyde + CO2." [EC:4.1.1.1] subset: gosubset_prok synonym: "2-oxo-acid carboxy-lyase (aldehyde-forming)" EXACT [EC:4.1.1.1] synonym: "2-oxo-acid carboxy-lyase activity" EXACT [EC:4.1.1.1] synonym: "alpha-carboxylase activity" EXACT [EC:4.1.1.1] synonym: "alpha-ketoacid carboxylase activity" EXACT [EC:4.1.1.1] synonym: "pyruvic decarboxylase activity" EXACT [EC:4.1.1.1] xref: EC:4.1.1.1 xref: MetaCyc:PYRUVATE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004738 name: pyruvate dehydrogenase activity namespace: molecular_function def: "Catalysis of the oxidative decarboxylation of pyruvate." [ISBN:0716020094] subset: gosubset_prok synonym: "pyruvic acid dehydrogenase activity" EXACT [EC:1.2.4.1] synonym: "pyruvic dehydrogenase activity" EXACT [EC:1.2.4.1] xref: MetaCyc:PYRUVOXID-RXN xref: MetaCyc:RXN0-1134 xref: Reactome:1965 "pyruvate dehydrogenase activity" is_a: GO:0016903 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors [Term] id: GO:0004739 name: pyruvate dehydrogenase (acetyl-transferring) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + lipoamide = S-acetyldihydrolipoamide + CO2." [EC:1.2.4.1] subset: gosubset_prok synonym: "MtPDC (mitochondrial pyruvate dehydogenase complex) activity" NARROW [EC:1.2.4.1] synonym: "PDH" RELATED [EC:1.2.4.1] synonym: "pyruvate dehydrogenase (lipoamide) activity" EXACT [] synonym: "pyruvate dehydrogenase complex activity" RELATED [EC:1.2.4.1] synonym: "pyruvate:dihydrolipoyllysine-residue acetyltransferase-lipoyllysine 2-oxidoreductase (decarboxylating, acceptor-acetylating)" EXACT [EC:1.2.4.1] synonym: "pyruvate:lipoamide 2-oxidoreductase (decarboxylating and acceptor-acetylating) activity" EXACT [EC:1.2.4.1] xref: EC:1.2.4.1 is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016624 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, disulfide as acceptor [Term] id: GO:0004740 name: pyruvate dehydrogenase (acetyl-transferring) kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate dehydrogenase (acetyl-transferring) = ADP + pyruvate dehydrogenase (acetyl-transferring) phosphate." [EC:2.7.11.2] synonym: "[pyruvate dehydrogenase (lipoamide)] kinase activity" EXACT [] synonym: "ATP:pyruvate dehydrogenase (acetyl-transferring) phosphotransferase activity" EXACT [EC:2.7.11.2] synonym: "PDH kinase activity" EXACT [EC:2.7.11.2] synonym: "PDHK" RELATED [EC:2.7.11.2] synonym: "PDK" RELATED [EC:2.7.11.2] synonym: "PDK1" RELATED [EC:2.7.11.2] synonym: "PDK2" RELATED [EC:2.7.11.2] synonym: "PDK3" RELATED [EC:2.7.11.2] synonym: "PDK4" RELATED [EC:2.7.11.2] synonym: "pyruvate dehydrogenase (lipoamide) kinase activity" EXACT [] synonym: "pyruvate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activator protein activity" NARROW [EC:2.7.11.2] synonym: "pyruvate dehydrogenase kinase activity" EXACT [EC:2.7.11.2] synonym: "STK1" RELATED [EC:2.7.11.2] xref: EC:2.7.11.2 xref: MetaCyc:2.7.11.2-RXN xref: Reactome:14233 "pyruvate dehydrogenase (acetyl-transferring) kinase activity" is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0004741 name: [pyruvate dehydrogenase (lipoamide)] phosphatase activity namespace: molecular_function alt_id: GO:0019906 def: "Catalysis of the reaction: [pyruvate dehydrogenase (lipoamide)] phosphate + H2O = [pyruvate dehydrogenase (lipoamide)] + phosphate." [EC:3.1.3.43] synonym: "[pyruvate dehydrogenase (lipoamide)] phosphatase, intrinsic catalyst activity" EXACT [] synonym: "phosphopyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide) phosphatase activity" EXACT [] synonym: "pyruvate dehydrogenase (lipoamide)-phosphatase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase (lipoamide)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.43] synonym: "pyruvate dehydrogenase phosphatase activity" EXACT [EC:3.1.3.43] xref: EC:3.1.3.43 xref: MetaCyc:3.1.3.43-RXN xref: Reactome:14236 "[pyruvate dehydrogenase (lipoamide)] phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0004742 name: dihydrolipoyllysine-residue acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + dihydrolipoamide = CoA + S-acetyldihydrolipoamide." [EC:2.3.1.12] subset: gosubset_prok synonym: "acetyl-CoA: enzyme-6-N-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA: enzyme-N6-(dihydrolipoyl)lysine S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "acetyl-CoA:dihydrolipoamide S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoamide S-acetyltransferase activity" EXACT [] synonym: "dihydrolipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "dihydrolipoyl acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "enzyme-dihydrolipoyllysine:acetyl-CoA S-acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoate transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic acid acetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "lipoic transacetylase activity" EXACT [EC:2.3.1.12] synonym: "lipoylacetyltransferase activity" EXACT [EC:2.3.1.12] synonym: "thioltransacetylase A activity" NARROW [EC:2.3.1.12] synonym: "transacetylase X activity" NARROW [EC:2.3.1.12] xref: EC:2.3.1.12 is_a: GO:0016418 ! S-acetyltransferase activity is_a: GO:0030523 ! dihydrolipoamide S-acyltransferase activity [Term] id: GO:0004743 name: pyruvate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate = ADP + phosphoenolpyruvate." [EC:2.7.1.40] subset: gosubset_prok synonym: "ATP:pyruvate 2-O-phosphotransferase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenol transphosphorylase activity" EXACT [EC:2.7.1.40] synonym: "phosphoenolpyruvate kinase activity" EXACT [EC:2.7.1.40] xref: EC:2.7.1.40 xref: MetaCyc:PEPDEPHOS-RXN xref: Reactome:14240 "pyruvate kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004744 name: retinal isomerase activity namespace: molecular_function def: "Catalysis of the reaction: all-trans-retinal = 11-cis-retinal." [EC:5.2.1.3] synonym: "all-trans-retinal 11-cis-trans-isomerase activity" EXACT [EC:5.2.1.3] synonym: "retinene isomerase activity" RELATED [EC:5.2.1.3] synonym: "retinoid isomerase activity" BROAD [EC:5.2.1.3] xref: EC:5.2.1.3 xref: MetaCyc:RETINAL-ISOMERASE-RXN is_a: GO:0016859 ! cis-trans isomerase activity [Term] id: GO:0004745 name: retinol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+." [EC:1.1.1.105] subset: gosubset_prok synonym: "all-trans retinol dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "MDR" RELATED [EC:1.1.1.105] synonym: "microsomal retinol dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "retinene reductase activity" EXACT [EC:1.1.1.105] synonym: "retinol (vitamin A1) dehydrogenase activity" EXACT [EC:1.1.1.105] synonym: "retinol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.105] xref: EC:1.1.1.105 xref: MetaCyc:RETINOL-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004746 name: riboflavin synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 6,7-dimethyl-8-(1-D-ribityl)lumazine = riboflavin + 4-(1-D-ribitylamino)-5-amino-2,6-dihydroxypyrimidine." [EC:2.5.1.9] subset: gosubset_prok synonym: "6,7-dimethyl-8-(1-D-ribityl)lumazine:6,7-dimethyl-8-(1-D-ribityl)lumazine 2,3-butanediyltransferase activity" EXACT [EC:2.5.1.9] synonym: "heavy riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "light riboflavin synthase" NARROW [EC:2.5.1.9] synonym: "lumazine synthase activity" BROAD [BRENDA:2.5.1.9] synonym: "riboflavin synthetase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthase activity" EXACT [EC:2.5.1.9] synonym: "riboflavine synthetase activity" EXACT [EC:2.5.1.9] synonym: "vitamin B2 synthase activity" EXACT [] xref: EC:2.5.1.9 xref: MetaCyc:RIBOFLAVIN-SYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004747 name: ribokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose = ADP + D-ribose 5-phosphate." [EC:2.7.1.15] subset: gosubset_prok synonym: "ATP:D-ribose 5-phosphotransferase activity" EXACT [EC:2.7.1.15] synonym: "D-ribokinase activity" EXACT [EC:2.7.1.15] synonym: "deoxyribokinase activity" EXACT [EC:2.7.1.15] synonym: "ribokinase (phosphorylating)" EXACT [EC:2.7.1.15] xref: EC:2.7.1.15 xref: MetaCyc:RIBOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004748 name: ribonucleoside-diphosphate reductase activity namespace: molecular_function alt_id: GO:0016959 alt_id: GO:0016960 alt_id: GO:0016961 def: "Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + thioredoxin disulfide + H2O = ribonucleoside diphosphate + thioredoxin. Thioredoxin disulfide is the oxidized form of thioredoxin." [EC:1.17.4.1] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-diphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "2'-deoxyribonucleoside-diphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.1] synonym: "adenosylcobalamin-dependent ribonucleotide reductase activity" EXACT [] synonym: "aerobic non-heme iron-dependent ribonucleotide reductase activity" EXACT [] synonym: "anaerobic iron-sulfur-dependent ribonucleotide reductase activity" EXACT [] synonym: "class I ribonucleotide reductase activity" EXACT [] synonym: "class II ribonucleoside-diphosphate reductase activity" EXACT [] synonym: "class II ribonucleotide reductase activity" EXACT [] synonym: "class III ribonucleotide reductase activity" EXACT [] synonym: "nucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "purine/pyrimidine nucleoside diphosphate reduction" RELATED [] synonym: "ribonucleoside 5'-diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleoside diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide diphosphate reductase activity" EXACT [EC:1.17.4.1] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.1] synonym: "RNR" EXACT [] xref: EC:1.17.4.1 xref: MetaCyc:RIBONUCLEOSIDE-DIP-REDUCTI-RXN xref: Reactome:4419 "class I ribonucleotide reductase activity" is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0004749 name: ribose phosphate diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribose 5-phosphate = AMP + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.7.6.1] subset: gosubset_prok synonym: "5-phosphoribose pyrophosphorylase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "5-phosphoribosyl-alpha-1-pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ATP:D-ribose-5-phosphate diphosphotransferase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl pyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosyl-diphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthase activity" EXACT [EC:2.7.6.1] synonym: "phosphoribosylpyrophosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "PP-ribose P synthetase activity" EXACT [EC:2.7.6.1] synonym: "PPRibP synthetase activity" EXACT [EC:2.7.6.1] synonym: "PRPP synthetase activity" EXACT [EC:2.7.6.1] synonym: "pyrophosphoribosylphosphate synthetase activity" EXACT [EC:2.7.6.1] synonym: "ribophosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-5-phosphate pyrophosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate diphosphokinase activity" EXACT [EC:2.7.6.1] synonym: "ribose-phosphate pyrophosphokinase activity" EXACT [] xref: EC:2.7.6.1 xref: MetaCyc:PRPPSYN-RXN xref: MetaCyc:PWY0-662 xref: Reactome:14245 "ribose phosphate diphosphokinase activity" is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004750 name: ribulose-phosphate 3-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribulose 5-phosphate = D-xylulose 5-phosphate." [EC:5.1.3.1] subset: gosubset_prok synonym: "D-ribulose 5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose phosphate-3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-P 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-ribulose-5-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "D-xylulose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate epimerase activity" EXACT [EC:5.1.3.1] synonym: "erythrose-4-phosphate isomerase activity" EXACT [EC:5.1.3.1] synonym: "pentose-5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoketopentose epimerase activity" EXACT [EC:5.1.3.1] synonym: "phosphoribulose epimerase activity" EXACT [EC:5.1.3.1] synonym: "ribulose 5-phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] synonym: "xylulose phosphate 3-epimerase activity" EXACT [EC:5.1.3.1] xref: EC:5.1.3.1 xref: MetaCyc:RIBULP3EPIM-RXN xref: Reactome:14262 "ribulose-phosphate 3-epimerase activity" is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0004751 name: ribose-5-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 5-phosphate = D-ribulose 5-phosphate." [EC:5.3.1.6] subset: gosubset_prok synonym: "5-phosphoribose isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose 5-phosphate isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.6] synonym: "D-ribose-5-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentoseisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphopentosisomerase activity" EXACT [EC:5.3.1.6] synonym: "phosphoriboisomerase activity" EXACT [EC:5.3.1.6] synonym: "ribose 5-phosphate epimerase activity" EXACT [EC:5.3.1.6] synonym: "ribose phosphate isomerase activity" EXACT [EC:5.3.1.6] xref: EC:5.3.1.6 xref: MetaCyc:RIB5PISOM-RXN xref: Reactome:14263 "ribose-5-phosphate isomerase activity" is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004753 name: saccharopine dehydrogenase activity namespace: molecular_function def: "Catalysis of the cleavage of N6-(L-1,3-dicarboxypropyl)-L-lysine to release an amino acid (lysine or glutamate), with the concomitant reduction of an electron acceptor." [GOC:mah] subset: gosubset_prok synonym: "lysine-2-oxoglutarate reductase activity" EXACT [EC:1.5.1.-] synonym: "lysine-ketoglutarate reductase activity" EXACT [EC:1.5.1.-] xref: EC:1.5.1.- xref: MetaCyc:1.5.1.7-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0004754 name: saccharopine dehydrogenase (NAD+, L-lysine-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O = L-lysine + 2-oxoglutarate + NADH + H+." [EC:1.5.1.7] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "dehydrogenase, saccharopine (nicotinamide adenine dinucleotide, lysine forming)" EXACT [EC:1.5.1.7] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD oxidoreductase (L-lysine forming)" EXACT [EC:1.5.1.7] synonym: "N6-(glutar-2-yl)-L-lysine:NAD oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NAD+ oxidoreductase (L-lysine-forming)" EXACT [EC:1.5.1.7] xref: EC:1.5.1.7 xref: MetaCyc:1.5.1.7-RXN is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004755 name: saccharopine dehydrogenase (NADP+, L-glutamate-forming) activity namespace: molecular_function def: "Catalysis of the reaction: N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O = L-glutamate + 2-aminoadipate 6-semialdehyde + NADPH + H+." [EC:1.5.1.10] subset: gosubset_prok synonym: "6-N-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "aminoadipate semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamate reductase activity" EXACT [EC:1.5.1.10] synonym: "aminoadipic semialdehyde-glutamic reductase activity" EXACT [EC:1.5.1.10] synonym: "epsilon-N-(L-glutaryl-2)-L-lysine:NAD+(P) oxidoreductase (L-2-aminoadipate-semialdehyde forming)" EXACT [EC:1.5.1.10] synonym: "N6-(L-1,3-dicarboxypropyl)-L-lysine:NADP+ oxidoreductase (L-glutamate-forming)" EXACT [EC:1.5.1.10] synonym: "saccharopine (nicotinamide adenine dinucleotide phosphate, glutamate-forming) dehydrogenase activity" EXACT [EC:1.5.1.10] synonym: "saccharopine reductase activity" EXACT [EC:1.5.1.10] xref: EC:1.5.1.10 xref: MetaCyc:RXN3O-127 is_a: GO:0004753 ! saccharopine dehydrogenase activity [Term] id: GO:0004756 name: selenide, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + selenide + H2O = AMP + selenophosphate + phosphate." [EC:2.7.9.3] subset: gosubset_prok synonym: "ATP:selenide, water phosphotransferase activity" EXACT [EC:2.7.9.3] synonym: "selenide,water dikinase activity" EXACT [EC:2.7.9.3] synonym: "selenium donor protein activity" EXACT [EC:2.7.9.3] synonym: "selenophosphate synthase activity" EXACT [] synonym: "selenophosphate synthetase activity" EXACT [EC:2.7.9.3] xref: EC:2.7.9.3 xref: MetaCyc:2.7.9.3-RXN xref: UM-BBD_enzymeID:e0509 is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0004757 name: sepiapterin reductase activity namespace: molecular_function def: "Catalysis of the reaction: 7,8-dihydrobiopterin + NADP+ = sepiapterin + NADPH + H+." [EC:1.1.1.153] subset: gosubset_prok synonym: "7,8-dihydrobiopterin:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.153] xref: EC:1.1.1.153 xref: MetaCyc:SEPIAPTERIN-REDUCTASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004758 name: serine C-palmitoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-CoA + L-serine = CoA + 3-dehydro-D-sphinganine + CO2." [EC:2.3.1.50] synonym: "3-oxosphinganine synthetase activity" EXACT [EC:2.3.1.50] synonym: "acyl-CoA:serine C-2 acyltransferase decarboxylating" RELATED [EC:2.3.1.50] synonym: "palmitoyl-CoA:L-serine C-palmitoyltransferase (decarboxylating) activity" EXACT [EC:2.3.1.50] synonym: "serine palmitoyltransferase" BROAD [] synonym: "SPT" RELATED [EC:2.3.1.50] xref: EC:2.3.1.50 xref: MetaCyc:SERINE-C-PALMITOYLTRANSFERASE-RXN xref: Reactome:14271 "serine C-palmitoyltransferase activity" is_a: GO:0016454 ! C-palmitoyltransferase activity [Term] id: GO:0004760 name: serine-pyruvate transaminase activity namespace: molecular_function alt_id: GO:0004761 alt_id: GO:0004762 alt_id: GO:0004763 def: "Catalysis of the reaction: L-serine + pyruvate = 3-hydroxypyruvate + L-alanine." [EC:2.6.1.51] subset: gosubset_prok synonym: "hydroxypyruvate:L-alanine transaminase activity" EXACT [EC:2.6.1.51] synonym: "L-serine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase activity" EXACT [] synonym: "serine-pyruvate aminotransferase, type 1" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2A" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B" NARROW [] synonym: "SPT" RELATED [EC:2.6.1.51] xref: EC:2.6.1.51 xref: MetaCyc:SERINE--PYRUVATE-AMINOTRANSFERASE-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0004764 name: shikimate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: shikimate + NADP+ = 5-dehydroshikimate + NADPH + H+." [EC:1.1.1.25] subset: gosubset_prok synonym: "5-dehydroshikimate reductase activity" EXACT [EC:1.1.1.25] synonym: "5-dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "dehydroshikimic reductase activity" EXACT [EC:1.1.1.25] synonym: "DHS reductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) 5-oxidoreductase activity" EXACT [EC:1.1.1.25] synonym: "shikimate:NADP(+) oxidoreductase activity" EXACT [EC:1.1.1.25] xref: EC:1.1.1.25 xref: MetaCyc:SHIKIMATE-5-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0004765 name: shikimate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + shikimate = ADP + shikimate 3-phosphate." [EC:2.7.1.71] subset: gosubset_prok synonym: "ATP:shikimate 3-phosphotransferase activity" EXACT [EC:2.7.1.71] synonym: "shikimate kinase (phosphorylating)" EXACT [EC:2.7.1.71] synonym: "shikimate kinase II" RELATED [EC:2.7.1.71] xref: EC:2.7.1.71 xref: MetaCyc:SHIKIMATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0004766 name: spermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + putrescine = 5'-methylthioadenosine + spermidine." [EC:2.5.1.16] subset: gosubset_prok synonym: "aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "putrescine aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "S-adenosylmethioninamine:putrescine 3-aminopropyltransferase activity" EXACT [EC:2.5.1.16] synonym: "SpeE" RELATED [EC:2.5.1.16] synonym: "spermidine synthetase activity" EXACT [EC:2.5.1.16] xref: EC:2.5.1.16 xref: MetaCyc:SPERMIDINESYN-RXN xref: Reactome:14296 "spermidine synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004767 name: sphingomyelin phosphodiesterase activity namespace: molecular_function alt_id: GO:0030230 alt_id: GO:0030231 def: "Catalysis of the reaction: sphingomyelin + H2O = N-acylsphingosine + choline phosphate." [EC:3.1.4.12] subset: gosubset_prok synonym: "acid sphingomyelin phosphodiesterase" NARROW [] synonym: "acid sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "neutral sphingomyelin phosphodiesterase" NARROW [] synonym: "neutral sphingomyelinase activity" NARROW [EC:3.1.4.12] synonym: "sphingomyelin cholinephosphohydrolase activity" EXACT [EC:3.1.4.12] synonym: "sphingomyelinase activity" EXACT [] xref: EC:3.1.4.12 xref: MetaCyc:SPHINGOMYELIN-PHOSPHODIESTERASE-RXN xref: Reactome:14297 "sphingomyelin phosphodiesterase activity" is_a: GO:0004620 ! phospholipase activity is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0004768 name: stearoyl-CoA 9-desaturase activity namespace: molecular_function alt_id: GO:0016214 alt_id: GO:0043735 def: "Catalysis of the reaction: stearoyl-CoA + 2 ferrocytochrome b5 + O2 + 2 H+ = oleoyl-CoA + 2 ferricytochrome b5 + H2O." [EC:1.14.19.1] comment: Note that this function was formerly EC:1.14.99.5. subset: gosubset_prok synonym: "acyl-CoA desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta(9)-desaturase activity" EXACT [EC:1.14.19.1] synonym: "delta-9 acyl-phospholipid desaturase activity" RELATED [] synonym: "delta9-desaturase activity" EXACT [EC:1.14.19.1] synonym: "fatty acid desaturase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA desaturase activity" EXACT [] synonym: "stearoyl-CoA, hydrogen-donor:oxygen oxidoreductase activity" EXACT [EC:1.14.19.1] synonym: "stearoyl-CoA,ferrocytochrome-b5:oxygen oxidoreductase (9,10-dehydrogenating)" EXACT [EC:1.14.19.1] xref: EC:1.14.19.1 xref: MetaCyc:1.14.19.1-RXN is_a: GO:0016717 ! oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water [Term] id: GO:0004769 name: steroid delta-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: a 3-oxo-delta(5)-steroid = a 3-oxo-delta(4)-steroid." [EC:5.3.3.1] subset: gosubset_prok synonym: "3-oxosteroid delta5-delta4-isomerase activity" EXACT [EC:5.3.3.1] synonym: "3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta(5)-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5(or delta4)-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-keto steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-3-oxosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-ketosteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "delta5-steroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "hydroxysteroid isomerase activity" EXACT [EC:5.3.3.1] synonym: "steroid D-isomerase activity" EXACT [] synonym: "steroid isomerase activity" EXACT [EC:5.3.3.1] xref: EC:5.3.3.1 xref: MetaCyc:STEROID-DELTA-ISOMERASE-RXN xref: Reactome:14301 "steroid delta-isomerase activity" is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0004770 name: sterol carrier protein X-related thiolase activity namespace: molecular_function xref: Reactome:14315 "sterol carrier protein X-related thiolase activity" is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004771 name: sterol esterase activity namespace: molecular_function def: "Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid." [EC:3.1.1.13] synonym: "acylcholesterol lipase activity" EXACT [EC:3.1.1.13] synonym: "cholesterase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesterol ester synthase activity" NARROW [EC:3.1.1.13] synonym: "cholesterol esterase activity" NARROW [EC:3.1.1.13] synonym: "cholesteryl ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl ester synthase activity" EXACT [EC:3.1.1.13] synonym: "cholesteryl esterase activity" EXACT [EC:3.1.1.13] synonym: "sterol ester hydrolase activity" EXACT [EC:3.1.1.13] synonym: "steryl-ester acylhydrolase activity" EXACT [EC:3.1.1.13] synonym: "triterpenol esterase activity" EXACT [EC:3.1.1.13] xref: EC:3.1.1.13 xref: MetaCyc:STEROL-ESTERASE-RXN xref: Reactome:14316 "sterol esterase activity" is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0004772 name: sterol O-acyltransferase activity namespace: molecular_function alt_id: GO:0017066 def: "Catalysis of the reaction: acyl-CoA + a sterol = CoA + a sterol ester." [EC:2.3.1.26, GOC:mah] synonym: "sterol-ester synthase activity" EXACT [EC:2.3.1.26] synonym: "sterol-ester synthetase activity" EXACT [EC:2.3.1.26] xref: MetaCyc:STEROL-O-ACYLTRANSFERASE-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0004773 name: steryl-sulfatase activity namespace: molecular_function def: "Catalysis of the reaction: 3-beta-hydroxyandrost-5-en-17-one 3-sulfate + H2O = 3-beta-hydroxyandrost-5-en-17-one + SO4(2-) (sulfate)." [EC:3.1.6.2] synonym: "3-beta-hydroxysteroid sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "arylsulfatase C activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "dehydroepiandrosterone sulfate sulfatase activity" EXACT [EC:3.1.6.2] synonym: "phenolic steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "pregnenolone sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid 3-sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steroid sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "sterol sulfatase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulfate sulfohydrolase activity" EXACT [EC:3.1.6.2] synonym: "steryl-sulphatase activity" EXACT [] xref: EC:3.1.6.2 xref: MetaCyc:STERYL-SULFATASE-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0004774 name: succinate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction between succinate and CoA to form succinyl-CoA." [EC:6.2.1.-, GOC:ai] subset: gosubset_prok xref: EC:6.2.1.- is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0004775 name: succinate-CoA ligase (ADP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + succinate + CoA = ADP + succinyl-CoA + phosphate." [EC:6.2.1.5] subset: gosubset_prok synonym: "A-SCS" RELATED [EC:6.2.1.5] synonym: "A-STK (adenin nucleotide-linked succinate thiokinase)" RELATED [EC:6.2.1.5] synonym: "succinate thiokinase activity" EXACT [EC:6.2.1.5] synonym: "succinate:CoA ligase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinic thiokinase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.5] synonym: "succinyl coenzyme A synthetase (adenosine diphosphate-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase (ADP-forming) activity" EXACT [EC:6.2.1.5] synonym: "succinyl-CoA synthetase activity" EXACT [EC:6.2.1.5] xref: EC:6.2.1.5 xref: MetaCyc:SUCCCOASYN-RXN xref: Reactome:14321 "succinate-CoA ligase (ADP-forming) activity" is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004776 name: succinate-CoA ligase (GDP-forming) activity namespace: molecular_function def: "Catalysis of the reaction: GTP + succinate + CoA = GDP + succinyl-CoA + phosphate." [EC:6.2.1.4] subset: gosubset_prok synonym: "G-STK" RELATED [EC:6.2.1.4] synonym: "P-enzyme" RELATED [EC:6.2.1.4] synonym: "SCS" RELATED [EC:6.2.1.4] synonym: "succinate-phosphorylating enzyme" RELATED [EC:6.2.1.4] synonym: "succinate:CoA ligase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinic thiokinase" BROAD [EC:6.2.1.4] synonym: "succinyl CoA synthetase activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase" BROAD [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl coenzyme A synthetase (guanosine diphosphate-forming) activity" EXACT [EC:6.2.1.4] synonym: "succinyl-CoA synthetase (GDP-forming) activity" EXACT [EC:6.2.1.4] xref: EC:6.2.1.4 xref: MetaCyc:SUCCINATE--COA-LIGASE-GDP-FORMING-RXN xref: Reactome:14322 "succinate-CoA ligase (GDP-forming) activity" is_a: GO:0004774 ! succinate-CoA ligase activity [Term] id: GO:0004777 name: succinate-semialdehyde dehydrogenase activity namespace: molecular_function alt_id: GO:0008952 def: "Catalysis of the reaction: succinate semialdehyde + NAD+ + H2O = succinate + NADH + H+." [EC:1.2.1.24] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinate semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinate-semialdehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.24] synonym: "succinic semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] synonym: "succinyl semialdehyde dehydrogenase activity" EXACT [EC:1.2.1.24] xref: EC:1.2.1.24 xref: MetaCyc:SUCCINATE-SEMIALDEHYDE-DEHYDROGENASE-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0004778 name: succinyl-CoA hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + H2O = CoA + succinate." [EC:3.1.2.3] synonym: "succinyl coenzyme A deacylase activity" EXACT [EC:3.1.2.3] synonym: "succinyl coenzyme A hydrolase activity" EXACT [EC:3.1.2.3] synonym: "succinyl-CoA acylase activity" EXACT [EC:3.1.2.3] xref: EC:3.1.2.3 xref: MetaCyc:SUCCINYL-COA-HYDROLASE-RXN is_a: GO:0016289 ! CoA hydrolase activity [Term] id: GO:0004779 name: sulfate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an adenylyl group from an adenosine nucleotide (ATP or ADP) to sulfate, forming adenylylsulfate." [GOC:mah, MetaCyc:SULFATE-ADENYLYLTRANS-RXN, MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN] subset: gosubset_prok synonym: "sulphate adenylyltransferase activity" EXACT [] xref: EC:2.7.7.- is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004780 name: sulfate adenylyltransferase (ADP) activity namespace: molecular_function def: "Catalysis of the reaction: ADP + SO4(2-) (sulfate) = phosphate + adenylylsulfate." [EC:2.7.7.5] synonym: "adenosine diphosphate sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP-sulfurylase activity" EXACT [EC:2.7.7.5] synonym: "ADP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate (adenosine diphosphate) adenylyltransferase activity" EXACT [EC:2.7.7.5] synonym: "sulphate adenylyltransferase (ADP) activity" EXACT [] xref: EC:2.7.7.5 xref: MetaCyc:SULFATE-ADENYLYLTRANSFERASE-ADP-RXN is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004781 name: sulfate adenylyltransferase (ATP) activity namespace: molecular_function def: "Catalysis of the reaction: ATP + SO4(2-) (sulfate) = diphosphate + adenylylsulfate." [EC:2.7.7.4] subset: gosubset_prok synonym: "adenosine-5'-triphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenosinetriphosphate sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "adenylylsulfate pyrophosphorylase activity" EXACT [EC:2.7.7.4] synonym: "ATP sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP-sulfurylase activity" EXACT [EC:2.7.7.4] synonym: "ATP:sulfate adenylyltransferase activity" EXACT [] synonym: "sulfate adenylate transferase activity" EXACT [EC:2.7.7.4] synonym: "sulfurylase activity" RELATED [EC:2.7.7.4] synonym: "sulphate adenylyltransferase (ATP) activity" EXACT [] xref: EC:2.7.7.4 xref: MetaCyc:SULFATE-ADENYLYLTRANS-RXN xref: Reactome:14341 "sulfate adenylyltransferase (ATP) activity" is_a: GO:0004779 ! sulfate adenylyltransferase activity [Term] id: GO:0004782 name: sulfinoalanine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfino-L-alanine = hypotaurine + CO2." [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase (hypotaurine-forming)" EXACT [EC:4.1.1.29] synonym: "3-sulfino-L-alanine carboxy-lyase activity" EXACT [EC:4.1.1.29] synonym: "CADCase/CSADCase activity" EXACT [EC:4.1.1.29] synonym: "CSAD" RELATED [EC:4.1.1.29] synonym: "CSADCase activity" EXACT [EC:4.1.1.29] synonym: "cysteic decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteine-sulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinate decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "L-cysteinesulfinic acid decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulfoalanine decarboxylase activity" EXACT [EC:4.1.1.29] synonym: "sulphinoalanine decarboxylase activity" EXACT [] xref: EC:4.1.1.29 xref: MetaCyc:SULFINOALANINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004783 name: sulfite reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: H2S + 3 NADP+ + 3 H2O = SO3(2-) (sulfite) + 3 NADPH + 3 H+." [EC:1.8.1.2] subset: gosubset_prok synonym: "H2S-NADP oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "hydrogen-sulfide:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-dependent sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH-sulfite reductase activity" EXACT [EC:1.8.1.2] synonym: "NADPH:sulfite reductase flavoprotein" RELATED [] synonym: "sulfite (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.8.1.2] synonym: "sulphite reductase (NADPH) activity" EXACT [] xref: EC:1.8.1.2 xref: MetaCyc:SULFITE-REDUCT-RXN is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004784 name: superoxide dismutase activity namespace: molecular_function alt_id: GO:0004785 alt_id: GO:0008382 alt_id: GO:0008383 alt_id: GO:0016954 def: "Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2." [EC:1.15.1.1] subset: gosubset_prok synonym: "copper, zinc superoxide dismutase activity" NARROW [] synonym: "Cu,Zn-SOD" RELATED [EC:1.15.1.1] synonym: "Cu-Zn superoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "cuprein" RELATED [EC:1.15.1.1] synonym: "cytocuprein" RELATED [EC:1.15.1.1] synonym: "erythrocuprein" RELATED [EC:1.15.1.1] synonym: "Fe-SOD" RELATED [EC:1.15.1.1] synonym: "ferrisuperoxide dismutase activity" NARROW [EC:1.15.1.1] synonym: "hemocuprein" RELATED [EC:1.15.1.1] synonym: "hepatocuprein" RELATED [EC:1.15.1.1] synonym: "iron superoxide dismutase activity" NARROW [] synonym: "iron superoxide oxidoreductase" RELATED [] synonym: "manganese superoxide dismutase activity" NARROW [] synonym: "manganese superoxide oxidoreductase" RELATED [] synonym: "Mn, Fe superoxide dismutase" NARROW [] synonym: "Mn-SOD" RELATED [EC:1.15.1.1] synonym: "nickel superoxide dismutase activity" NARROW [] synonym: "nickel superoxide oxidoreductase" RELATED [] synonym: "SOD" RELATED [EC:1.15.1.1] synonym: "SOD-1" RELATED [EC:1.15.1.1] synonym: "SOD-2" RELATED [EC:1.15.1.1] synonym: "SOD-3" RELATED [EC:1.15.1.1] synonym: "SOD-4" RELATED [EC:1.15.1.1] synonym: "SODF" RELATED [EC:1.15.1.1] synonym: "SODS" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase I" RELATED [EC:1.15.1.1] synonym: "superoxide dismutase II" RELATED [EC:1.15.1.1] synonym: "superoxide:superoxide oxidoreductase activity" EXACT [] synonym: "zinc superoxide oxidoreductase" RELATED [] xref: EC:1.15.1.1 xref: MetaCyc:SUPEROX-DISMUT-RXN is_a: GO:0016209 ! antioxidant activity is_a: GO:0016721 ! oxidoreductase activity, acting on superoxide radicals as acceptor [Term] id: GO:0004786 name: Mn, Fe superoxide dismutase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the function is covered by an existing term. is_obsolete: true consider: GO:0004784 [Term] id: GO:0004787 name: thiamin-pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: TDP + H2O = TMP + phosphate." [EC:3.6.1.-, GOC:ai] synonym: "thiamin pyrophosphatase activity" EXACT [] synonym: "thiamine pyrophosphatase activity" EXACT [] synonym: "thiaminpyrophosphatase activity" EXACT [EC:3.6.1.6] synonym: "TPPase activity" EXACT [] xref: EC:3.6.1.- is_a: GO:0017110 ! nucleoside-diphosphatase activity [Term] id: GO:0004788 name: thiamin diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin = AMP + thiamin diphosphate." [EC:2.7.6.2] subset: gosubset_prok synonym: "ATP:thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "ATP:thiamine diphosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin pyrophosphokinase activity" EXACT [] synonym: "thiamin pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamin:ATP pyrophosphotransferase activity" EXACT [EC:2.7.6.2] synonym: "thiamine diphosphokinase activity" EXACT [EC:2.7.6.2] synonym: "thiamine pyrophosphokinase activity" EXACT [] synonym: "thiaminokinase activity" EXACT [EC:2.7.6.2] synonym: "TPTase activity" EXACT [EC:2.7.6.2] xref: EC:2.7.6.2 xref: MetaCyc:THIAMIN-PYROPHOSPHOKINASE-RXN xref: Reactome:14348 "thiamin diphosphokinase activity" is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0004789 name: thiamin-phosphate diphosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-methyl-4-amino-5-hydroxymethylpyrimidine diphosphate + 4-4-methyl-5-(2-phosphonooxyethyl)-thiazole = diphosphate + thiamin monophosphate." [EC:2.5.1.3] subset: gosubset_prok synonym: "2-methyl-4-amino-5-hydroxymethylpyrimidine-diphosphate:4-methyl-5-(2-phosphoethyl)thiazole 2-methyl-4-aminopyrimidine-5-methenyltransferase activity" EXACT [EC:2.5.1.3] synonym: "thiamin-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine monophosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine phosphate pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "thiamine-phosphate pyrophosphorylase activity" EXACT [] synonym: "thiamine-phosphate synthase activity" EXACT [EC:2.5.1.3] synonym: "TMP diphosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP pyrophosphorylase activity" EXACT [EC:2.5.1.3] synonym: "TMP-PPase activity" EXACT [EC:2.5.1.3] xref: EC:2.5.1.3 xref: MetaCyc:THI-P-SYN-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004790 name: thioether S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl sulfide = S-adenosyl-L-homocysteine + trimethylsulfonium." [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:dimethyl-sulfide S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "S-adenosyl-L-methionine:thioether S-methyltransferase activity" EXACT [EC:2.1.1.96] synonym: "thioether methyltransferase activity" EXACT [EC:2.1.1.96] xref: EC:2.1.1.96 xref: MetaCyc:THIOETHER-S-METHYLTRANSFERASE-RXN is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004791 name: thioredoxin-disulfide reductase activity namespace: molecular_function def: "Catalysis of the reaction: thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+." [EC:1.8.1.9, ISBN:0198547684] subset: gosubset_prok synonym: "NADP--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH--thioredoxin reductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH2:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "NADPH:oxidized thioredoxin oxidoreductase activity" EXACT [EC:1.8.1.9] synonym: "thioredoxin disulfide reductase activity" EXACT [] synonym: "thioredoxin reductase (NADPH) activity" EXACT [] synonym: "thioredoxin-disulphide reductase activity" EXACT [] synonym: "thioredoxin:NADP+ oxidoreductase activity" EXACT [EC:1.8.1.9] xref: EC:1.8.1.9 xref: MetaCyc:THIOREDOXIN-REDUCT-NADPH-RXN xref: Reactome:14367 "thioredoxin-disulfide reductase activity" is_a: GO:0016209 ! antioxidant activity is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0004792 name: thiosulfate sulfurtransferase activity namespace: molecular_function def: "Catalysis of the reaction: thiosulfate + cyanide = SO3(2-) (sulfite) + thiocyanate." [EC:2.8.1.1] subset: gosubset_prok synonym: "rhodanase activity" EXACT [EC:2.8.1.1] synonym: "rhodanese activity" RELATED [EC:2.8.1.1] synonym: "thiosulfate cyanide transsulfurase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate thiotransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulfate:cyanide sulfurtransferase activity" EXACT [EC:2.8.1.1] synonym: "thiosulphate sulphurtransferase activity" EXACT [] xref: EC:2.8.1.1 xref: MetaCyc:THIOSULFATE-SULFURTRANSFERASE-RXN is_a: GO:0016783 ! sulfurtransferase activity [Term] id: GO:0004793 name: threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = glycine + acetaldehyde." [EC:4.1.2.5] subset: gosubset_prok synonym: "L-threonine acetaldehyde-lyase (glycine-forming)" EXACT [EC:4.1.2.5] synonym: "L-threonine acetaldehyde-lyase activity" EXACT [EC:4.1.2.5] synonym: "L-threonine aldolase activity" EXACT [] xref: EC:4.1.2.5 xref: MetaCyc:THREONINE-ALDOLASE-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0004794 name: L-threonine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine = 2-oxobutanoate + NH3." [EC:4.3.1.19] comment: Note that this function was formerly EC:4.2.1.16. subset: gosubset_prok synonym: "L-serine dehydratase activity" RELATED [EC:4.3.1.19] synonym: "L-threonine ammonia-lyase (2-oxobutanoate-forming)" EXACT [EC:4.3.1.19] synonym: "L-threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine dehydratase activity" EXACT [EC:4.3.1.19] synonym: "L-threonine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.19] synonym: "serine deaminase activity" RELATED [EC:4.3.1.19] synonym: "threonine ammonia-lyase activity" EXACT [] synonym: "threonine deaminase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydrase activity" EXACT [EC:4.3.1.19] synonym: "threonine dehydratase activity" EXACT [] xref: EC:4.3.1.19 xref: MetaCyc:THREDEHYD-RXN xref: UM-BBD_enzymeID:e0306 is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0004795 name: threonine synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-phospho-L-homoserine + H2O = L-threonine + phosphate." [EC:4.2.3.1] subset: gosubset_prok synonym: "O-phospho-L-homoserine phospho-lyase (adding water)" EXACT [EC:4.2.3.1] synonym: "O-phospho-L-homoserine phospho-lyase (adding water; L-threonine-forming)" EXACT [EC:4.2.3.1] synonym: "threonine synthetase activity" EXACT [EC:4.2.3.1] xref: EC:4.2.3.1 xref: MetaCyc:THRESYN-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0004796 name: thromboxane-A synthase activity namespace: molecular_function alt_id: GO:0008400 def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-9-alpha,11-alpha-epoxy-15-hydroxythromba-5,13-dienoate." [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate isomerase activity" EXACT [EC:5.3.99.5] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate thromboxane-A2-isomerase activity" EXACT [EC:5.3.99.5] synonym: "cytochrome P450 CYP5" NARROW [] synonym: "thromboxane synthase activity" EXACT [EC:5.3.99.5] synonym: "thromboxane synthetase activity" EXACT [EC:5.3.99.5] xref: EC:5.3.99.5 xref: MetaCyc:THROMBOXANE-A-SYNTHASE-RXN xref: Reactome:14373 "thromboxane-A synthase activity" is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0004797 name: thymidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine = ADP + thymidine 5'-phosphate." [EC:2.7.1.21] subset: gosubset_prok synonym: "2'-deoxythymidine kinase activity" EXACT [EC:2.7.1.21] synonym: "ATP:thymidine 5'-phosphotransferase activity" EXACT [EC:2.7.1.21] synonym: "deoxythymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] synonym: "thymidine kinase (phosphorylating)" EXACT [EC:2.7.1.21] xref: EC:2.7.1.21 xref: MetaCyc:THYKI-RXN is_a: GO:0019136 ! deoxynucleoside kinase activity [Term] id: GO:0004798 name: thymidylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thymidine 5'-phosphate = ADP + thymidine 5'-diphosphate." [EC:2.7.4.9] subset: gosubset_prok synonym: "ATP:dTMP phosphotransferase activity" EXACT [EC:2.7.4.9] synonym: "deoxythymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "dTMP kinase activity" EXACT [] synonym: "thymidine 5'-monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidine monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylate monophosphate kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic acid kinase activity" EXACT [EC:2.7.4.9] synonym: "thymidylic kinase activity" EXACT [EC:2.7.4.9] synonym: "TMPK activity" EXACT [EC:2.7.4.9] xref: EC:2.7.4.9 xref: MetaCyc:DTMPKI-RXN is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0004799 name: thymidylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = dihydrofolate + dTMP." [EC:2.1.1.45] subset: gosubset_prok synonym: "5,10-methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "dTMP synthase activity" EXACT [EC:2.1.1.45] synonym: "methylenetetrahydrofolate:dUMP C-methyltransferase activity" EXACT [EC:2.1.1.45] synonym: "thymidylate synthetase activity" EXACT [EC:2.1.1.45] synonym: "TMP synthetase activity" EXACT [EC:2.1.1.45] xref: EC:2.1.1.45 xref: MetaCyc:THYMIDYLATESYN-RXN xref: Reactome:14376 "thymidylate synthase activity" is_a: GO:0042083 ! 5,10-methylenetetrahydrofolate-dependent methyltransferase activity [Term] id: GO:0004800 name: thyroxine 5'-deiodinase activity namespace: molecular_function def: "Catalysis of the reaction: 3,5,3'-L-triiodo-L-thyronine + iodide + acceptor + H+ = L-thyroxine + donor-H2." [EC:1.97.1.10] comment: Note that this was EC:3.8.1.4. synonym: "acceptor:3,5,3'-triiodo-L-thyronine oxidoreductase (iodinating)" EXACT [EC:1.97.1.10] synonym: "diiodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine 5'-deiodinase activity" EXACT [EC:1.97.1.10] synonym: "iodothyronine outer ring monodeiodinase activity" EXACT [EC:1.97.1.10] synonym: "L-thyroxine iodohydrolase (reducing) activity" EXACT [EC:1.97.1.10] synonym: "thyroxine 5' deiodinase activity" EXACT [] synonym: "thyroxine deiodinase activity" BROAD [] synonym: "type I iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] synonym: "type II iodothyronine deiodinase activity" NARROW [EC:1.97.1.10] xref: EC:1.97.1.10 xref: MetaCyc:THYROXINE-DEIODINASE-RXN xref: Reactome:15048 "thyroxine 5'-deiodinase activity" is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004801 name: transaldolase activity namespace: molecular_function def: "Catalysis of the reaction: sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate = D-erythrose 4-phosphate + D-fructose 6-phosphate." [EC:2.2.1.2] subset: gosubset_prok synonym: "dihydroxyacetone transferase activity" EXACT [EC:2.2.1.2] synonym: "dihydroxyacetonetransferase activity" EXACT [EC:2.2.1.2] synonym: "glycerone transferase activity" EXACT [EC:2.2.1.2] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glyceronetransferase activity" EXACT [EC:2.2.1.2] xref: EC:2.2.1.2 xref: MetaCyc:TRANSALDOL-RXN xref: Reactome:15049 "transaldolase activity" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004802 name: transketolase activity namespace: molecular_function def: "Catalysis of the reversible transfer of a 2-carbon ketol group (CH2OH-CO-) from a ketose phosphate donor to an aldose phosphate acceptor." [EC:2.2.1.1, GOC:fmc] subset: gosubset_prok synonym: "fructose 6-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [GOC:fmc, GOC:mah] synonym: "glycoaldehyde transferase activity" EXACT [EC:2.2.1.1] synonym: "glycolaldehydetransferase activity" EXACT [EC:2.2.1.1] synonym: "sedoheptulose-7-phosphate:D-glyceraldehyde-3-phosphate glycolaldehydetransferase activity" NARROW [EC:2.2.1.1] xref: EC:2.2.1.1 xref: MetaCyc:1TRANSKETO-RXN xref: Reactome:15050 "transketolase activity" is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0004803 name: transposase activity namespace: molecular_function def: "Catalysis of the transposition of transposable elements or transposons. Transposases are involved in site-specific DNA recombination required for transposition in bacteria and other organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0004804 name: P-element encoded transposase activity namespace: molecular_function is_a: GO:0004803 ! transposase activity [Term] id: GO:0004805 name: trehalose-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: trehalose 6-phosphate + H2O = trehalose + phosphate." [EC:3.1.3.12] subset: gosubset_prok synonym: "trehalose 6-phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose 6-phosphate phosphatase activity" EXACT [EC:3.1.3.12] synonym: "trehalose phosphatase activity" EXACT [] synonym: "trehalose-6-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.12] xref: EC:3.1.3.12 xref: MetaCyc:TREHALOSEPHOSPHA-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0004806 name: triglyceride lipase activity namespace: molecular_function def: "Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a fatty acid anion." [EC:3.1.1.3] subset: gosubset_prok synonym: "amano AP" RELATED [EC:3.1.1.3] synonym: "amano B" RELATED [EC:3.1.1.3] synonym: "amano CE" RELATED [EC:3.1.1.3] synonym: "amano CES" RELATED [EC:3.1.1.3] synonym: "amano P" RELATED [EC:3.1.1.3] synonym: "amno N-AP" RELATED [EC:3.1.1.3] synonym: "butyrinase activity" EXACT [EC:3.1.1.3] synonym: "cacordase activity" EXACT [EC:3.1.1.3] synonym: "capalase L" RELATED [EC:3.1.1.3] synonym: "GA 56" RELATED [EC:3.1.1.3] synonym: "GEH" RELATED [EC:3.1.1.3] synonym: "glycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "glycerol-ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "heparin releasable hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic lipase" NARROW [EC:3.1.1.3] synonym: "hepatic monoacylglycerol acyltransferase" NARROW [EC:3.1.1.3] synonym: "lipazin" RELATED [EC:3.1.1.3] synonym: "liver lipase" NARROW [EC:3.1.1.3] synonym: "meito MY 30" RELATED [EC:3.1.1.3] synonym: "meito sangyo OF lipase" RELATED [EC:3.1.1.3] synonym: "post-heparin plasma protamine-resistant lipase" NARROW [EC:3.1.1.3] synonym: "PPL" RELATED [EC:3.1.1.3] synonym: "salt-resistant post-heparin lipase" NARROW [EC:3.1.1.3] synonym: "steapsin" RELATED [EC:3.1.1.3] synonym: "takedo 1969-4-9" RELATED [EC:3.1.1.3] synonym: "triacetinase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol acylhydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol ester hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triacylglycerol lipase activity" EXACT [EC:3.1.1.3] synonym: "tributyrase activity" RELATED [EC:3.1.1.3] synonym: "tributyrin esterase activity" EXACT [EC:3.1.1.3] synonym: "tributyrinase activity" EXACT [EC:3.1.1.3] synonym: "triglyceridase activity" EXACT [EC:3.1.1.3] synonym: "triglyceride hydrolase activity" EXACT [EC:3.1.1.3] synonym: "triolein hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween hydrolase activity" EXACT [EC:3.1.1.3] synonym: "tween-hydrolyzing esterase activity" EXACT [EC:3.1.1.3] synonym: "tweenase activity" EXACT [EC:3.1.1.3] synonym: "tweenesterase activity" EXACT [EC:3.1.1.3] xref: EC:3.1.1.3 xref: MetaCyc:TRIACYLGLYCEROL-LIPASE-RXN xref: Reactome:15058 "triglyceride lipase activity" is_a: GO:0004091 ! carboxylesterase activity is_a: GO:0016298 ! lipase activity [Term] id: GO:0004807 name: triose-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate = glycerone phosphate." [EC:5.3.1.1] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.1] synonym: "D-glyceraldehyde-3-phosphate ketol-isomerase activity" EXACT [EC:5.3.1.1] synonym: "phosphotriose isomerase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphate mutase activity" EXACT [EC:5.3.1.1] synonym: "triose phosphoisomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate isomerase activity" EXACT [EC:5.3.1.1] synonym: "triosephosphate mutase activity" EXACT [EC:5.3.1.1] xref: EC:5.3.1.1 xref: MetaCyc:TRIOSEPISOMERIZATION-RXN xref: Reactome:70450 "triose-phosphate isomerase activity" is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0004808 name: tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase activity namespace: molecular_function alt_id: GO:0016425 def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 5-methylaminomethyl-2-thiouridylate." [EC:2.1.1.61] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (5-methylaminomethyl-2-thio-uridylate)-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "transfer ribonucleate 5-methylaminomethyl-2-thiouridylate 5-methyltransferase activity" EXACT [EC:2.1.1.61] synonym: "tRNA 5-methylaminomethyl-2-thiouridylate 5'-methyltransferase activity" EXACT [EC:2.1.1.61] xref: EC:2.1.1.61 xref: MetaCyc:2.1.1.61-RXN is_a: GO:0008175 ! tRNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004809 name: tRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N2-methylguanine." [EC:2.1.1.32] subset: gosubset_prok synonym: "guanine-N2-methylase activity" EXACT [EC:2.1.1.32] synonym: "N(2),N(2)-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "N2,N2-dimethylguanine tRNA methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer ribonucleate guanine N2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "transfer RNA guanine 2-methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA 2,2-dimethylguanosine-26 methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N(2)-N(2)) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(guanine-26,N2-N2) methyltransferase activity" EXACT [EC:2.1.1.32] synonym: "tRNA(m(2,2)G26)dimethyltransferase activity" EXACT [EC:2.1.1.32] xref: EC:2.1.1.32 xref: MetaCyc:TRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0004810 name: tRNA adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + tRNA(n) = diphosphate + tRNA(n+1)." [EC:2.7.7.25] subset: gosubset_prok synonym: "-C-C-A pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ATP (CTP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP(CTP)-tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ATP:tRNA adenylyltransferase activity" EXACT [] synonym: "CCA-adding enzyme activity" RELATED [EC:2.7.7.25] synonym: "CTP(ATP):tRNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylic cytidylic adenylic pyrophosphorylase" BROAD [EC:2.7.7.25] synonym: "ribonucleic cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate adenyltransferase activity" EXACT [EC:2.7.7.25] synonym: "transfer ribonucleate adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate cytidylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleate nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic acid nucleotidyl transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic adenylyl (cytidylyl) transferase" BROAD [EC:2.7.7.25] synonym: "transfer ribonucleic-terminal trinucleotide nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer RNA adenylyltransferase" BROAD [EC:2.7.7.25] synonym: "transfer-RNA nucleotidyltransferase" BROAD [EC:2.7.7.25] synonym: "tRNA adenylyl(cytidylyl)transferase" BROAD [EC:2.7.7.25] synonym: "tRNA CCA-diphosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA CCA-pyrophosphorylase activity" RELATED [EC:2.7.7.25] synonym: "tRNA-nucleotidyltransferase activity" BROAD [EC:2.7.7.25] xref: EC:2.7.7.25 xref: MetaCyc:TRNA-ADENYLYLTRANSFERASE-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0004811 name: tRNA isopentenyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: isopentenyl diphosphate + tRNA = diphosphate + tRNA containing 6-isopentenyladenosine." [EC:2.5.1.8] subset: gosubset_prok synonym: "delta2-isopentenyl pyrophosphate:transfer ribonucleic acid delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.8] synonym: "delta2-isopentenyl pyrophosphate:tRNA-delta2-isopentenyl transferase activity" EXACT [EC:2.5.1.8] synonym: "IPP transferase activity" EXACT [EC:2.5.1.8] synonym: "isopentenyl-diphosphate:tRNA isopentenyltransferase activity" EXACT [EC:2.5.1.8] synonym: "transfer ribonucleate isopentenyltransferase activity" EXACT [EC:2.5.1.8] xref: EC:2.5.1.8 xref: MetaCyc:RXN0-6274 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0004812 name: aminoacyl-tRNA ligase activity namespace: molecular_function def: "Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of pyrophosphate and AMP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the bond resulting from this reaction is a carboxylic acid ester bond, linking the alpha carboxyl group of the amino acid to either the 2' or 3' hydroxyl of the 3'- terminal adenyl residue of the tRNA. subset: gosubset_prok synonym: "aminoacyl-tRNA synthetase activity" EXACT [GOC:hjd] xref: EC:6.1.1.- is_a: GO:0016876 ! ligase activity, forming aminoacyl-tRNA and related compounds [Term] id: GO:0004813 name: alanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-alanine + tRNA(Ala) = AMP + diphosphate + L-alanyl-tRNA(Ala)." [EC:6.1.1.7] subset: gosubset_prok synonym: "Ala-tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine translase activity" EXACT [EC:6.1.1.7] synonym: "alanine tRNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanine-transfer RNA ligase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.7] synonym: "alanyl-tRNA synthetase activity" EXACT [] synonym: "AlaRS" RELATED [EC:6.1.1.7] synonym: "L-alanine:tRNAAla ligase (AMP-forming)" EXACT [EC:6.1.1.7] xref: EC:6.1.1.7 xref: MetaCyc:ALANINE--TRNA-LIGASE-RXN xref: Reactome:15078 "alanine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004814 name: arginine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arginine + tRNA(Arg) = AMP + diphosphate + L-arginyl-tRNA(Arg)." [EC:6.1.1.19] subset: gosubset_prok synonym: "arginine translase activity" EXACT [EC:6.1.1.19] synonym: "arginine-tRNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.19] synonym: "arginyl-tRNA synthetase activity" EXACT [] synonym: "L-arginine:tRNAArg ligase (AMP-forming)" EXACT [EC:6.1.1.19] xref: EC:6.1.1.19 xref: MetaCyc:ARGININE--TRNA-LIGASE-RXN xref: Reactome:15079 "arginine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004815 name: aspartate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-aspartate + tRNA(Asp) = AMP + diphosphate + L-aspartyl-tRNA(Asp)." [EC:6.1.1.12] subset: gosubset_prok synonym: "aspartic acid translase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleate synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl ribonucleic synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.12] synonym: "aspartyl-tRNA synthetase activity" EXACT [] synonym: "L-aspartate:tRNAAsp ligase (AMP-forming)" EXACT [EC:6.1.1.12] xref: EC:6.1.1.12 xref: MetaCyc:ASPARTATE--TRNA-LIGASE-RXN xref: Reactome:15081 "aspartate-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004816 name: asparagine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-asparagine + tRNA(Asn) = AMP + diphosphate + L-asparaginyl-tRNA(Asn)." [EC:6.1.1.22] subset: gosubset_prok synonym: "asparagine translase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.22] synonym: "asparaginyl-tRNA synthetase activity" EXACT [] synonym: "asparagyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.22] synonym: "L-asparagine:tRNAAsn ligase (AMP-forming)" EXACT [EC:6.1.1.22] xref: EC:6.1.1.22 xref: MetaCyc:ASPARAGINE--TRNA-LIGASE-RXN xref: Reactome:15083 "asparagine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004817 name: cysteine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-cysteine + tRNA(Cys) = AMP + diphosphate + L-cysteinyl-tRNA(Cys)." [EC:6.1.1.16] subset: gosubset_prok synonym: "cysteine translase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-transferRNA synthetase activity" EXACT [EC:6.1.1.16] synonym: "cysteinyl-tRNA synthetase activity" EXACT [] synonym: "L-cysteine:tRNACys ligase (AMP-forming)" EXACT [EC:6.1.1.16] xref: EC:6.1.1.16 xref: MetaCyc:CYSTEINE--TRNA-LIGASE-RXN xref: Reactome:15084 "cysteine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004818 name: glutamate-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamate + tRNA(Glu) = AMP + diphosphate + L-glutamyl-tRNA(Glu)." [EC:6.1.1.17] subset: gosubset_prok synonym: "glutamate-tRNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamic acid translase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.17] synonym: "glutamyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamate:tRNAGlu ligase (AMP-forming) activity" EXACT [EC:6.1.1.17] xref: EC:6.1.1.17 xref: MetaCyc:GLURS-RXN xref: Reactome:15085 "glutamate-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004819 name: glutamine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-glutamine + tRNA(Gln) = AMP + diphosphate + L-glutaminyl-tRNA(Gln)." [EC:6.1.1.18] subset: gosubset_prok synonym: "GlnRS" RELATED [EC:6.1.1.18] synonym: "glutamine translase activity" EXACT [EC:6.1.1.18] synonym: "glutamine-tRNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl ribonucleic acid" RELATED [EC:6.1.1.18] synonym: "glutaminyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.18] synonym: "glutaminyl-tRNA synthetase activity" EXACT [] synonym: "L-glutamine:tRNAGln ligase (AMP-forming)" EXACT [EC:6.1.1.18] xref: EC:6.1.1.18 xref: MetaCyc:GLUTAMINE--TRNA-LIGASE-RXN xref: Reactome:15087 "glutamine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004820 name: glycine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly)." [EC:6.1.1.14] subset: gosubset_prok synonym: "glycine:tRNAGly ligase (AMP-forming) activity" EXACT [EC:6.1.1.14] synonym: "glycyl translase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.14] synonym: "glycyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.14 xref: MetaCyc:GLYCINE--TRNA-LIGASE-RXN xref: Reactome:15097 "glycine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004821 name: histidine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-histidine + tRNA(His) = AMP + diphosphate + L-histidyl-tRNA(His)." [EC:6.1.1.21] subset: gosubset_prok synonym: "histidine translase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.21] synonym: "histidyl-tRNA synthetase activity" EXACT [] synonym: "L-histidine:tRNAHis ligase (AMP-forming)" EXACT [EC:6.1.1.21] xref: EC:6.1.1.21 xref: MetaCyc:HISTIDINE--TRNA-LIGASE-RXN xref: Reactome:15098 "histidine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004822 name: isoleucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-isoleucine + tRNA(Ile) = AMP + diphosphate + L-isoleucyl-tRNA(Ile)." [EC:6.1.1.5] subset: gosubset_prok synonym: "isoleucine translase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-transfer RNA ligase activity" EXACT [EC:6.1.1.5] synonym: "isoleucine-tRNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.5] synonym: "isoleucyl-tRNA synthetase activity" EXACT [] synonym: "L-isoleucine:tRNAIle ligase (AMP-forming)" EXACT [EC:6.1.1.5] xref: EC:6.1.1.5 xref: MetaCyc:ISOLEUCINE--TRNA-LIGASE-RXN xref: Reactome:15099 "isoleucine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004823 name: leucine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-leucine + tRNA(Leu) = AMP + diphosphate + L-leucyl-tRNA(Leu)." [EC:6.1.1.4] subset: gosubset_prok synonym: "L-leucine:tRNALeu ligase (AMP-forming)" EXACT [EC:6.1.1.4] synonym: "leucine translase activity" EXACT [EC:6.1.1.4] synonym: "leucine-tRNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.4] synonym: "leucyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.4 xref: MetaCyc:LEUCINE--TRNA-LIGASE-RXN xref: Reactome:15100 "leucine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004824 name: lysine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-lysine + tRNA(Lys) = AMP + diphosphate + L-lysyl-tRNA(Lys)." [EC:6.1.1.6] subset: gosubset_prok synonym: "L-lysine-transfer RNA ligase activity" EXACT [EC:6.1.1.6] synonym: "L-lysine:tRNALys ligase (AMP-forming)" EXACT [EC:6.1.1.6] synonym: "lysine translase activity" EXACT [EC:6.1.1.6] synonym: "lysine-tRNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.6] synonym: "lysyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.6 xref: MetaCyc:LYSINE--TRNA-LIGASE-RXN xref: Reactome:15101 "lysine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004825 name: methionine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-methionine + tRNA(Met) = AMP + diphosphate + L-methionyl-tRNA(Met)." [EC:6.1.1.10] subset: gosubset_prok synonym: "L-methionine:tRNAMet ligase (AMP-forming)" EXACT [EC:6.1.1.10] synonym: "methionine translase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.10] synonym: "methionyl-tRNA synthetase activity" EXACT [] synonym: "MetRS activity" EXACT [EC:6.1.1.10] xref: EC:6.1.1.10 xref: MetaCyc:METHIONINE--TRNA-LIGASE-RXN xref: Reactome:15102 "methionine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004826 name: phenylalanine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok synonym: "L-phenylalanine:tRNAPhe ligase (AMP-forming) activity" EXACT [EC:6.1.1.20] synonym: "L-phenylalanyl-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine translase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanine-tRNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA ligase activity" EXACT [EC:6.1.1.20] synonym: "phenylalanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.20 xref: MetaCyc:PHENYLALANINE--TRNA-LIGASE-RXN xref: Reactome:15104 "phenylalanine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004827 name: proline-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-proline + tRNA(Pro) = AMP + diphosphate + L-prolyl-tRNA(Pro)." [EC:6.1.1.15] subset: gosubset_prok synonym: "L-proline:tRNAPro ligase (AMP-forming)" EXACT [EC:6.1.1.15] synonym: "proline translase activity" EXACT [EC:6.1.1.15] synonym: "prolinyl-tRNA ligase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-s-RNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-transferRNA synthetase activity" EXACT [EC:6.1.1.15] synonym: "prolyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.15 xref: MetaCyc:PROLINE--TRNA-LIGASE-RXN xref: Reactome:15107 "proline-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004828 name: serine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-serine + tRNA(Ser) = AMP + diphosphate + L-seryl-tRNA(Ser)." [EC:6.1.1.11] subset: gosubset_prok synonym: "L-serine:tRNASer ligase (AMP-forming)" EXACT [EC:6.1.1.11] synonym: "serine translase activity" EXACT [EC:6.1.1.11] synonym: "SerRS activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-transfer RNA synthetase activity" EXACT [EC:6.1.1.11] synonym: "seryl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.11 xref: MetaCyc:SERINE--TRNA-LIGASE-RXN xref: Reactome:15110 "serine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004829 name: threonine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-threonine + tRNA(Thr) = AMP + diphosphate + L-threonyl-tRNA(Thr)." [EC:6.1.1.3] subset: gosubset_prok synonym: "L-threonine:tRNAThr ligase (AMP-forming)" EXACT [EC:6.1.1.3] synonym: "threonine translase activity" EXACT [EC:6.1.1.3] synonym: "threonine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl ribonucleic synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.3] synonym: "threonyl-tRNA synthetase activity" EXACT [] synonym: "TRS" RELATED [EC:6.1.1.3] xref: EC:6.1.1.3 xref: MetaCyc:THREONINE--TRNA-LIGASE-RXN xref: Reactome:15113 "threonine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004830 name: tryptophan-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tryptophan + tRNA(Trp) = AMP + diphosphate + L-tryptophanyl-tRNA(Trp)." [EC:6.1.1.2] subset: gosubset_prok synonym: "L-tryptophan-tRNA(Trp) ligase (AMP-forming) activity" EXACT [EC:6.1.1.2] synonym: "L-tryptophan-tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "L-tryptophan:tRNATrp ligase (AMP-forming)" EXACT [EC:6.1.1.2] synonym: "TrpRS activity" EXACT [EC:6.1.1.2] synonym: "tryptophan translase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer ribonucleic synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthase activity" EXACT [EC:6.1.1.2] synonym: "tryptophanyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.2 xref: MetaCyc:TRYPTOPHAN--TRNA-LIGASE-RXN xref: Reactome:15130 "tryptophan-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004831 name: tyrosine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-tyrosine + tRNA(Tyr) = AMP + diphosphate + L-tyrosyl-tRNA(Tyr)." [EC:6.1.1.1] subset: gosubset_prok synonym: "L-tyrosine-tRNA(Tyr) ligase (AMP-forming) activity" EXACT [EC:6.1.1.1] synonym: "L-tyrosine-tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "L-tyrosine:tRNATyr ligase (AMP-forming)" EXACT [EC:6.1.1.1] synonym: "tyrosine translase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine tRNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosine-transfer RNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA ligase activity" EXACT [EC:6.1.1.1] synonym: "tyrosyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.1 xref: MetaCyc:TYROSINE--TRNA-LIGASE-RXN xref: Reactome:15131 "tyrosine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004832 name: valine-tRNA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-valine + tRNA(Val) = AMP + diphosphate + L-valyl-tRNA(Val)." [EC:6.1.1.9] subset: gosubset_prok synonym: "L-valine:tRNAVal ligase (AMP-forming)" EXACT [EC:6.1.1.9] synonym: "valine transfer ribonucleate ligase activity" EXACT [EC:6.1.1.9] synonym: "valine translase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleate synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer ribonucleic acid synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-transfer RNA synthetase activity" EXACT [EC:6.1.1.9] synonym: "valyl-tRNA synthetase activity" EXACT [] xref: EC:6.1.1.9 xref: MetaCyc:VALINE--TRNA-LIGASE-RXN xref: Reactome:15132 "valine-tRNA ligase activity" is_a: GO:0004812 ! aminoacyl-tRNA ligase activity [Term] id: GO:0004833 name: tryptophan 2,3-dioxygenase activity namespace: molecular_function alt_id: GO:0004426 def: "Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine." [EC:1.13.11.11] subset: gosubset_prok synonym: "indolamine 2,3-dioxygenase activity" BROAD [EC:1.13.11.11] synonym: "indoleamine-pyrrole 2,3-dioxygenase activity" EXACT [] synonym: "L-tryptophan 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan pyrrolase activity" EXACT [EC:1.13.11.11] synonym: "L-tryptophan:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.11] synonym: "TDO" RELATED [EC:1.13.11.11] synonym: "tryptamin 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptamine 2,3-dioxygenase activity" EXACT [EC:1.13.11.11] synonym: "tryptophan oxygenase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan peroxidase activity" BROAD [EC:1.13.11.11] synonym: "tryptophan pyrrolase activity" BROAD [EC:1.13.11.11] xref: EC:1.13.11.11 xref: MetaCyc:TRYPTOPHAN-23-DIOXYGENASE-RXN xref: Reactome:15133 "tryptophan 2,3-dioxygenase activity" is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0004834 name: tryptophan synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-serine + 1-(indol-3-yl)glycerol 3-phosphate = L-tryptophan + glyceraldehyde 3-phosphate + H2O." [EC:4.2.1.20] subset: gosubset_prok synonym: "indoleglycerol phosphate aldolase activity" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase (adding indoleglycerol-phosphate)" EXACT [EC:4.2.1.20] synonym: "L-serine hydro-lyase [adding 1-C-(indol-3-yl)glycerol 3-phosphate; L-tryptophan and glyceraldehyde-3-phosphate-forming]" RELATED [EC:4.2.1.20] synonym: "L-tryptophan synthetase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan desmolase activity" EXACT [EC:4.2.1.20] synonym: "tryptophan synthetase activity" EXACT [EC:4.2.1.20] xref: EC:4.2.1.20 xref: MetaCyc:TRYPSYN-RXN is_a: GO:0016836 ! hydro-lyase activity relationship: part_of GO:0000162 ! tryptophan biosynthetic process [Term] id: GO:0004835 name: tubulin-tyrosine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + detyrosinated alpha-tubulin + L-tyrosine = alpha-tubulin + ADP + phosphate." [EC:6.3.2.25] synonym: "alpha-tubulin:L-tyrosine ligase (ADP-forming)" EXACT [EC:6.3.2.25] synonym: "TTL activity" EXACT [EC:6.3.2.25] synonym: "tubulinyl-tyrosine ligase activity" EXACT [] xref: EC:6.3.2.25 xref: MetaCyc:6.3.2.25-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0004836 name: tyramine-beta hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of tyramine to form octopamine." [PMID:10745161] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0004837 name: tyrosine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine = tyramine + CO2." [EC:4.1.1.25] synonym: "L-(-)-tyrosine apodecarboxylase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase (tyramine-forming)" EXACT [EC:4.1.1.25] synonym: "L-tyrosine carboxy-lyase activity" EXACT [EC:4.1.1.25] synonym: "L-tyrosine decarboxylase activity" EXACT [EC:4.1.1.25] xref: EC:4.1.1.25 xref: MetaCyc:TYROSINE-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004838 name: L-tyrosine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-tyrosine + 2-oxoglutarate = 4-hydroxyphenylpyruvate + L-glutamate." [EC:2.6.1.5] subset: gosubset_prok synonym: "glutamic phenylpyruvic aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "glutamic-hydroxyphenylpyruvic transaminase activity" RELATED [EC:2.6.1.5] synonym: "L-phenylalanine 2-oxoglutarate aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "L-tyrosine aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "phenylalanine aminotransferase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylalanine-alpha-ketoglutarate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvate transaminase activity" RELATED [EC:2.6.1.5] synonym: "phenylpyruvic acid transaminase activity" RELATED [EC:2.6.1.5] synonym: "TyrAT activity" RELATED [EC:2.6.1.5] synonym: "tyrosine aminotransferase activity" BROAD [] synonym: "tyrosine transaminase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-2-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate aminotransferase activity" BROAD [EC:2.6.1.5] synonym: "tyrosine-alpha-ketoglutarate transaminase activity" BROAD [EC:2.6.1.5] xref: EC:2.6.1.5 xref: MetaCyc:TYROSINE-AMINOTRANSFERASE-RXN xref: Reactome:15141 "L-tyrosine:2-oxoglutarate aminotransferase activity" is_a: GO:0070547 ! L-tyrosine aminotransferase activity [Term] id: GO:0004839 name: ubiquitin activating enzyme activity namespace: molecular_function def: "Catalysis of the activation of the C-terminal carboxyl group of ubiquitin by the formation of a high-energy thiolester bond in an ATP-dependent manner." [http://www.bostonbiochem.com/E-301.html, PMID:10072378] synonym: "E1" EXACT [] xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: Wikipedia:Ubiquitin-activating_enzyme is_a: GO:0008641 ! small protein activating enzyme activity [Term] id: GO:0004842 name: ubiquitin-protein ligase activity namespace: molecular_function alt_id: GO:0004840 alt_id: GO:0004841 def: "Catalysis of the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine." [EC:6.3.2.19, PMID:9635407] subset: gosubset_prok synonym: "anaphase-promoting complex activity" NARROW [GOC:dph, GOC:tairtb] synonym: "E2" NARROW [] synonym: "E3" NARROW [] synonym: "ubiquitin activity" RELATED [EC:6.3.2.19] synonym: "ubiquitin conjugating enzyme activity" EXACT [] synonym: "ubiquitin ligase activity" EXACT [] synonym: "ubiquitin protein ligase activity" EXACT [] synonym: "ubiquitin protein-ligase activity" EXACT [] synonym: "ubiquitin-conjugating enzyme activity" EXACT [] synonym: "ubiquitin-ligase activity" EXACT [] synonym: "ubiquitin:protein-lysine N-ligase (AMP-forming) activity" EXACT [EC:6.3.2.19] xref: EC:6.3.2.19 xref: MetaCyc:UBIQUITIN--PROTEIN-LIGASE-RXN xref: Reactome:202455 "ubiquitin-protein ligase activity" is_a: GO:0019787 ! small conjugating protein ligase activity relationship: part_of GO:0016567 ! protein ubiquitination [Term] id: GO:0004843 name: ubiquitin-specific protease activity namespace: molecular_function def: "Catalysis of the hydrolysis of various forms of polymeric ubiquitin sequences." [ISBN:0120793709] comment: Note that this term is distinguished from 'ubiquitin thiolesterase activity ; GO:0004221' in that it encompasses hydrolysis of any type of bonds formed between ubiquitin and another protein. subset: gosubset_prok synonym: "ubiquitin hydrolase activity" EXACT [GOC:rl] synonym: "UBP" NARROW [] synonym: "UCH2" NARROW [] xref: Reactome:15173 "ubiquitin-specific protease activity" is_a: GO:0019783 ! small conjugating protein-specific protease activity [Term] id: GO:0004844 name: uracil DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine." [GOC:elh, PMID:9224623] subset: gosubset_prok synonym: "uracil-DNA glycosylase activity" EXACT [] xref: EC:3.2.2.- xref: Reactome:15174 "uracil DNA N-glycosylase activity" is_a: GO:0019104 ! DNA N-glycosylase activity [Term] id: GO:0004845 name: uracil phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UMP + diphosphate = uracil + 5-phospho-alpha-D-ribose 1-diphosphate." [EC:2.4.2.9] subset: gosubset_prok synonym: "UMP diphosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "UMP:diphosphate phospho-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UMP:pyrophosphate phosphoribosyltransferase activity" EXACT [EC:2.4.2.9] synonym: "UPRTase activity" EXACT [EC:2.4.2.9] synonym: "uridine 5'-phosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridine monophosphate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylate pyrophosphorylase activity" EXACT [EC:2.4.2.9] synonym: "uridylic pyrophosphorylase activity" EXACT [EC:2.4.2.9] xref: EC:2.4.2.9 xref: MetaCyc:URACIL-PRIBOSYLTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004846 name: urate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: urate + O2 + H2O = 5-hydroxyisourate + H2O2." [EC:1.7.3.3] subset: gosubset_prok synonym: "urate:oxygen oxidoreductase activity" EXACT [EC:1.7.3.3] synonym: "uric acid oxidase activity" EXACT [EC:1.7.3.3] synonym: "uricase activity" EXACT [EC:1.7.3.3] synonym: "uricase II activity" NARROW [EC:1.7.3.3] xref: EC:1.7.3.3 xref: MetaCyc:URATE-OXIDASE-RXN xref: UM-BBD_enzymeID:e0832 is_a: GO:0016663 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, oxygen as acceptor [Term] id: GO:0004847 name: urea carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + urea + CO2 = ADP + phosphate + urea-1-carboxylate." [EC:6.3.4.6] subset: gosubset_prok synonym: "ATP--urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "UALase activity" EXACT [EC:6.3.4.6] synonym: "UCA activity" EXACT [EC:6.3.4.6] synonym: "urea amidolyase activity" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urea carboxylase (hydrolyzing) activity" EXACT [EC:6.3.4.6] synonym: "urea:carbon-dioxide ligase (ADP-forming)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolysing)" EXACT [EC:6.3.4.6] synonym: "urease (ATP-hydrolyzing) activity" EXACT [EC:6.3.4.6] xref: EC:6.3.4.6 xref: MetaCyc:UREA-CARBOXYLASE-RXN is_a: GO:0016879 ! ligase activity, forming carbon-nitrogen bonds [Term] id: GO:0004848 name: ureidoglycolate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: (-)-ureidoglycolate + H2O = glyoxylate + 2 NH3 + CO2." [EC:3.5.3.19] subset: gosubset_prok synonym: "(S)-ureidoglycolate amidohydrolase (decarboxylating)" EXACT [EC:3.5.3.19] xref: EC:3.5.3.19 xref: MetaCyc:UREIDOGLYCOLATE-HYDROLASE-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0004849 name: uridine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + uridine = ADP + UMP." [EC:2.7.1.48] subset: gosubset_prok synonym: "ATP:uridine 5'-phosphotransferase activity" EXACT [EC:2.7.1.48] synonym: "pyrimidine ribonucleoside kinase activity" EXACT [EC:2.7.1.48] synonym: "uridine kinase (phosphorylating)" EXACT [EC:2.7.1.48] synonym: "uridine kinase reaction" EXACT [] synonym: "uridine monophosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine phosphokinase activity" EXACT [EC:2.7.1.48] synonym: "uridine-cytidine kinase activity" EXACT [EC:2.7.1.48] xref: EC:2.7.1.48 xref: MetaCyc:URIDINEKIN-RXN is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0004850 name: uridine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: uridine + phosphate = uracil + alpha-D-ribose 1-phosphate." [EC:2.4.2.3] subset: gosubset_prok synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.3] synonym: "UPase activity" EXACT [EC:2.4.2.3] synonym: "UPH" RELATED [EC:2.4.2.3] synonym: "UrdPase activity" EXACT [EC:2.4.2.3] synonym: "uridine:phosphate alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.3] xref: EC:2.4.2.3 xref: MetaCyc:URPHOS-RXN xref: Reactome:15196 "uridine phosphorylase activity" is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0004851 name: uroporphyrin-III C-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2 S-adenosyl-L-methionine + uroporphyrin III = 2 S-adenosyl-L-homocysteine + precorrin-2." [EC:2.1.1.107] subset: gosubset_prok synonym: "adenosylmethionine-uroporphyrinogen III methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "CobA" RELATED [EC:2.1.1.107] synonym: "CysG" RELATED [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine-dependent uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrin-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "S-adenosyl-L-methionine:uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "SirA" RELATED [EC:2.1.1.107] synonym: "SUMT activity" EXACT [EC:2.1.1.107] synonym: "urogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III C-methyltransferase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methylase activity" EXACT [EC:2.1.1.107] synonym: "uroporphyrinogen-III methyltransferase activity" EXACT [EC:2.1.1.107] xref: EC:2.1.1.107 xref: MetaCyc:UROPORIIIMETHYLTRANSA-RXN is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0004852 name: uroporphyrinogen-III synthase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxymethylbilane = uroporphyrinogen-III + H2O." [EC:4.2.1.75] subset: gosubset_prok synonym: "hydroxymethylbilane hydro-lyase (cyclizing) activity" EXACT [EC:4.2.1.75] synonym: "hydroxymethylbilane hydro-lyase (cyclizing; uroporphyrinogen-III-forming)" EXACT [EC:4.2.1.75] synonym: "porphobilinogenase activity" EXACT [EC:4.2.1.75] synonym: "URO-synthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen isomerase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthase activity" EXACT [EC:4.2.1.75] synonym: "uroporphyrinogen-III cosynthetase activity" EXACT [EC:4.2.1.75] xref: EC:4.2.1.75 xref: MetaCyc:UROGENIIISYN-RXN xref: Reactome:15200 "uroporphyrinogen-III synthase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0004853 name: uroporphyrinogen decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: uroporphyrinogen-III = coproporphyrinogen + 4 CO2." [EC:4.1.1.37] subset: gosubset_prok synonym: "porphyrinogen carboxy-lyase activity" EXACT [EC:4.1.1.37] synonym: "porphyrinogen decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen III decarboxylase activity" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase (coproporphyrinogen-III-forming)" EXACT [EC:4.1.1.37] synonym: "uroporphyrinogen-III carboxy-lyase activity" EXACT [EC:4.1.1.37] xref: EC:4.1.1.37 xref: MetaCyc:UROGENDECARBOX-RXN xref: Reactome:15202 "uroporphyrinogen decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0004854 name: xanthine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + NAD+ + H2O = urate + NADH + H+." [EC:1.17.1.4] subset: gosubset_prok synonym: "NAD-xanthine dehydrogenase activity" EXACT [EC:1.17.1.4] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.1.4] synonym: "xanthine-NAD oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD(+) oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine/NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] synonym: "xanthine:NAD+ oxidoreductase activity" EXACT [EC:1.17.1.4] xref: EC:1.17.1.4 xref: MetaCyc:RXN0-901 is_a: GO:0016726 ! oxidoreductase activity, acting on CH or CH2 groups, NAD or NADP as acceptor [Term] id: GO:0004855 name: xanthine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: xanthine + H2O + O2 = urate + H2O2." [EC:1.17.3.2] subset: gosubset_prok synonym: "hypoxanthine-xanthine oxidase activity" BROAD [EC:1.17.3.2] synonym: "schardinger enzyme" RELATED [EC:1.17.3.2] synonym: "Schardinger enzyme activity" RELATED [EC:1.17.3.2] synonym: "xanthine oxidoreductase activity" BROAD [EC:1.17.3.2] synonym: "xanthine:O(2) oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:O2 oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:oxygen oxidoreductase activity" EXACT [EC:1.17.3.2] synonym: "xanthine:xanthine oxidase activity" EXACT [EC:1.17.3.2] xref: EC:1.17.3.2 xref: MetaCyc:XANTHINE-OXIDASE-RXN xref: Reactome:15204 "xanthine oxidase activity" xref: UM-BBD_enzymeID:e0781 is_a: GO:0016727 ! oxidoreductase activity, acting on CH or CH2 groups, oxygen as acceptor [Term] id: GO:0004856 name: xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-xylulose = ADP + D-xylulose 5-phosphate." [EC:2.7.1.17] subset: gosubset_prok synonym: "ATP:D-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.17] synonym: "D-xylulokinase activity" EXACT [EC:2.7.1.17] synonym: "xylulokinase (phosphorylating)" EXACT [EC:2.7.1.17] synonym: "xylulose kinase activity" EXACT [EC:2.7.1.17] xref: EC:2.7.1.17 xref: MetaCyc:XYLULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0004857 name: enzyme inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an enzyme." [GOC:ai] subset: gosubset_prok is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0004858 name: dUTP pyrophosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of dUTP pyrophosphatase." [GOC:mah] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004170 ! dUTP diphosphatase activity [Term] id: GO:0004859 name: phospholipase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a phospholipase, an enzyme that catalyzes of the hydrolysis of a phospholipid." [GOC:ai, GOC:rl] is_a: GO:0055102 ! lipase inhibitor activity relationship: negatively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0004860 name: protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein kinase, an enzyme which phosphorylates a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0019210 ! kinase inhibitor activity is_a: GO:0019887 ! protein kinase regulator activity relationship: negatively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0004861 name: cyclin-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cyclin-dependent protein kinase." [GOC:mah] synonym: "CDK inhibitor" RELATED [] synonym: "cyclin dependent kinase inhibitor" RELATED [] synonym: "cyclin dependent protein kinase inhibitor activity" EXACT [] synonym: "cyclin-dependent kinase inhibitor" RELATED [] xref: Reactome:15226 "cyclin-dependent protein kinase inhibitor activity" is_a: GO:0016538 ! cyclin-dependent protein kinase regulator activity is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity relationship: negatively_regulates GO:0004693 ! cyclin-dependent protein kinase activity [Term] id: GO:0004862 name: cAMP-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a cAMP-dependent protein kinase." [GOC:mah] xref: Reactome:15228 "cAMP-dependent protein kinase inhibitor activity" is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity relationship: negatively_regulates GO:0004691 ! cAMP-dependent protein kinase activity [Term] id: GO:0004864 name: phosphoprotein phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a protein phosphatase, an enzyme that hydrolyzes phosphate groups from phosphorylated proteins." [GOC:ai] synonym: "protein phosphatase inhibitor activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0019212 ! phosphatase inhibitor activity relationship: negatively_regulates GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0004865 name: protein serine/threonine phosphatase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a serine/threonine protein phosphatase, an enzyme that catalyzes the reaction: protein serine/threonine phosphate + H20 = protein serine/threonine + phosphate." [GOC:dph, GOC:tb] is_a: GO:0004864 ! phosphoprotein phosphatase inhibitor activity [Term] id: GO:0004866 name: endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of an endopeptidase, any enzyme that hydrolyzes nonterminal peptide bonds in polypeptides." [GOC:jl] subset: gosubset_prok synonym: "alpha-2 macroglobulin" RELATED [] synonym: "endoproteinase inhibitor" EXACT [] synonym: "proteinase inhibitor" BROAD [] is_a: GO:0030414 ! peptidase inhibitor activity is_a: GO:0061135 ! endopeptidase regulator activity relationship: negatively_regulates GO:0004175 ! endopeptidase activity relationship: part_of GO:0010951 ! negative regulation of endopeptidase activity [Term] id: GO:0004867 name: serine-type endopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of serine-type endopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain; a serine residue (and a histidine residue) are at the active center of the enzyme." [GOC:ai] subset: gosubset_prok synonym: "serine protease inhibitor activity" EXACT [] synonym: "serine proteinase inhibitor activity" EXACT [] synonym: "serpin activity" NARROW [] xref: Reactome:15233 "serine-type endopeptidase inhibitor activity" is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0004252 ! serine-type endopeptidase activity [Term] id: GO:0004868 name: serpin namespace: molecular_function def: "OBSOLETE. A superfamily of proteins, many of which inhibit serine proteinases and exhibit a high degree of homology with classical serine proteinase inhibitors such as alpha1-antitrypsin or antithrombin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0004867 [Term] id: GO:0004869 name: cysteine-type endopeptidase inhibitor activity namespace: molecular_function alt_id: GO:0004870 def: "Stops, prevents or reduces the activity of a cysteine-type endopeptidase, any enzyme that hydrolyzes peptide bonds in polypeptides by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "cysteine protease inhibitor activity" EXACT [GOC:dph, GOC:tb] synonym: "thiol protease inhibitor" EXACT [] is_a: GO:0004866 ! endopeptidase inhibitor activity relationship: negatively_regulates GO:0008234 ! cysteine-type peptidase activity [Term] id: GO:0004871 name: signal transducer activity namespace: molecular_function def: "Mediates the transfer of a signal from the outside to the inside of a cell by means other than the introduction of the signal molecule itself into the cell." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Ligands do NOT have the molecular function 'signal transducer activity'. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0060089 ! molecular transducer activity relationship: part_of GO:0007165 ! signal transduction [Term] id: GO:0004872 name: receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "receptor guanylate cyclase activity" NARROW [] is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0004873 name: asialoglycoprotein receptor activity namespace: molecular_function def: "The mediation of the endocytosis of plasma glycoproteins from which the terminal sialic acid residue on their complex carbohydrate moieties has been removed; recognizes the terminal galactose and N-acetylgalactosamine units; the complex of receptor and ligand is internalized and transported to a sorting organelle where disassociation occurs, the receptor being recycled to the cell membrane." [PMID:11278827] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004874 name: aryl hydrocarbon receptor activity namespace: molecular_function def: "Combining with an aryl hydrocarbon to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity [Term] id: GO:0004875 name: complement receptor activity namespace: molecular_function def: "Combining with any component or product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that the complement cascade includes all of the components involved in the classical complement pathway, the alternative complement pathway, and the lectin complement pathway, as well as the common components of all three pathways. is_a: GO:0001848 ! complement binding is_a: GO:0004888 ! transmembrane receptor activity relationship: part_of GO:0002430 ! complement receptor mediated signaling pathway [Term] id: GO:0004876 name: complement component C3a receptor activity namespace: molecular_function def: "Combining with the C3a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004877 name: complement component C3b receptor activity namespace: molecular_function def: "Combining with the C3b product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001850 ! complement component C3a binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004878 name: complement component C5a receptor activity namespace: molecular_function def: "Combining with the C5a product of the complement cascade to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001856 ! complement component C5a binding is_a: GO:0004875 ! complement receptor activity [Term] id: GO:0004879 name: ligand-dependent nuclear receptor activity namespace: molecular_function def: "A ligand-dependent receptor found in the nucleus of the cell." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "nuclear hormone receptor" NARROW [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0004880 name: juvenile hormone receptor activity namespace: molecular_function def: "Combining with juvenile hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity relationship: part_of GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0004882 name: androgen receptor activity namespace: molecular_function def: "Combining with an androgen to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity relationship: part_of GO:0030521 ! androgen receptor signaling pathway [Term] id: GO:0004883 name: glucocorticoid receptor activity namespace: molecular_function def: "Combining with a glucocorticoid to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity relationship: part_of GO:0042921 ! glucocorticoid receptor signaling pathway relationship: part_of GO:0043402 ! glucocorticoid mediated signaling pathway [Term] id: GO:0004884 name: ecdysteroid hormone receptor activity namespace: molecular_function def: "Combining with ecdysteroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0003707 ! steroid hormone receptor activity relationship: part_of GO:0035076 ! ecdysone receptor-mediated signaling pathway [Term] id: GO:0004886 name: retinoid-X receptor activity namespace: molecular_function def: "Combining with 9-cis retinoic acid to initiate a change in cell activity." [PMID:17132853] synonym: "RXR" EXACT [] is_a: GO:0003708 ! retinoic acid receptor activity [Term] id: GO:0004887 name: thyroid hormone receptor activity namespace: molecular_function def: "Combining with thyroid hormone to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. is_a: GO:0004879 ! ligand-dependent nuclear receptor activity [Term] id: GO:0004888 name: transmembrane receptor activity namespace: molecular_function def: "Combining with an extracellular or intracellular messenger to initiate a change in cell activity, and spanning to the membrane of either the cell or an organelle." [GOC:go_curators, Wikipedia:Transmembrane_receptor] subset: gosubset_prok is_a: GO:0004872 ! receptor activity [Term] id: GO:0004889 name: nicotinic acetylcholine-activated cation-selective channel activity namespace: molecular_function alt_id: GO:0016904 is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0004890 name: GABA-A receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-A receptors function as chloride channels." [PMID:8974333] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'chloride channel activity ; GO:0005254' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004892 name: B cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0003823 [Term] id: GO:0004894 name: T cell receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes a receptor type, and not an activity. is_obsolete: true consider: GO:0032394 consider: GO:0032395 consider: GO:0042605 [Term] id: GO:0004895 name: cell adhesion receptor activity namespace: molecular_function def: "OBSOLETE. Combining with cell adhesion molecules to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0004896 name: cytokine receptor activity namespace: molecular_function alt_id: GO:0004907 def: "Combining with a cytokine to initiate a change in cell activity." [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor activity" RELATED [] synonym: "IL receptor" NARROW [] synonym: "interleukin receptor activity" NARROW [] is_a: GO:0004888 ! transmembrane receptor activity is_a: GO:0019955 ! cytokine binding relationship: part_of GO:0019221 ! cytokine-mediated signaling pathway [Term] id: GO:0004897 name: ciliary neurotrophic factor receptor activity namespace: molecular_function def: "Combining with ciliary neurotrophic factor to initiate a change in cell activity." [GOC:mah] synonym: "CNTF receptor activity" EXACT [GOC:mah] synonym: "gp130" NARROW [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004898 name: gp130 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004897 consider: GO:0004915 consider: GO:0004921 consider: GO:0005062 [Term] id: GO:0004900 name: erythropoietin receptor activity namespace: molecular_function def: "Combining with erythropoietin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004901 name: granulocyte macrophage colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030525 def: "Combining with granulocyte macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-2" RELATED [] synonym: "GM-CSF receptor activity" EXACT [] synonym: "GMC-SF receptor activity" EXACT [] synonym: "granulocyte macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004900 ! erythropoietin receptor activity [Term] id: GO:0004902 name: granulocyte colony-stimulating factor receptor activity namespace: molecular_function alt_id: GO:0030524 def: "Combining with granulocyte colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "granulocyte colony stimulating factor receptor activity" EXACT [] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004903 name: growth hormone receptor activity namespace: molecular_function def: "Combining with growth hormone to initiate a change in cell activity." [GOC:ai] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004904 name: interferon receptor activity namespace: molecular_function def: "Combining with an interferon to initiate a change in cell activity." [GOC:ai] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019961 ! interferon binding [Term] id: GO:0004905 name: type I interferon receptor activity namespace: molecular_function def: "Combining with a type I interferon to initiate a change in cell activity. Type I interferons include the interferon-alpha, beta, delta, epsilon, zeta, kappa, tau, and omega gene families." [GOC:add, ISBN:0126896631, PMID:15546383, PMID:16681834] synonym: "interferon-alpha receptor activity" NARROW [] synonym: "interferon-alpha/beta receptor activity" NARROW [] synonym: "interferon-beta receptor activity" NARROW [] synonym: "interferon-delta receptor activity" NARROW [] synonym: "interferon-epsilon receptor activity" NARROW [] synonym: "interferon-kappa receptor activity" NARROW [] synonym: "interferon-omega receptor activity" NARROW [] synonym: "interferon-tau receptor activity" NARROW [] synonym: "interferon-zeta receptor activity" NARROW [] is_a: GO:0004904 ! interferon receptor activity is_a: GO:0019962 ! type I interferon binding [Term] id: GO:0004906 name: interferon-gamma receptor activity namespace: molecular_function def: "Combining with interferon-gamma to initiate a change in cell activity. Interferon-gamma is also known as type II interferon." [GOC:add, GOC:ai, ISBN:0126896631, PMID:15546383] synonym: "type II interferon receptor activity" EXACT [] is_a: GO:0004904 ! interferon receptor activity is_a: GO:0019964 ! interferon-gamma binding [Term] id: GO:0004908 name: interleukin-1 receptor activity namespace: molecular_function def: "Combining with interleukin-1 to initiate a change in cell activity. Interleukin-1 is produced mainly by activated macrophages and is involved in the inflammatory response." [GOC:jl] synonym: "IL-1 receptor activity" EXACT [] synonym: "IL-1R" EXACT [] xref: Wikipedia:Interleukin-1_receptor is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019966 ! interleukin-1 binding [Term] id: GO:0004909 name: interleukin-1, Type I, activating receptor activity namespace: molecular_function alt_id: GO:0019967 def: "Combining with interleukin-1 to initiate a change in cell activity via signaling pathways and mediated by adaptor proteins." [PMID:15062641, PMID:18613828] synonym: "IL-1 type I, activating binding" EXACT [] synonym: "IL-1 type I, activating receptor" EXACT [] synonym: "interleukin-1 activating receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 Type I receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, Type I, activating binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004910 name: interleukin-1, Type II, blocking receptor activity namespace: molecular_function alt_id: GO:0019968 def: "Combining with interleukin-1 to initiate a change in cell activity by inhibiting the activity of type I interleukin receptors." [PMID:15062641, PMID:18613828] synonym: "IL-1 type II, blocking binding" EXACT [] synonym: "IL-1 type II, blocking receptor" EXACT [] synonym: "interleukin-1 blocking receptor activity" EXACT [GOC:mah] synonym: "interleukin-1 Type II receptor activity" EXACT [GOC:mah] synonym: "interleukin-1, Type II, blocking binding" RELATED [] is_a: GO:0004908 ! interleukin-1 receptor activity [Term] id: GO:0004911 name: interleukin-2 receptor activity namespace: molecular_function def: "Combining with interleukin-2 to initiate a change in cell activity." [GOC:jl] synonym: "IL-2 receptor activity" EXACT [GOC:mah] synonym: "IL-2R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019976 ! interleukin-2 binding [Term] id: GO:0004912 name: interleukin-3 receptor activity namespace: molecular_function def: "Combining with interleukin-3 to initiate a change in cell activity." [GOC:jl] synonym: "IL-3 receptor activity" EXACT [GOC:mah] synonym: "IL-3R" EXACT [] xref: Wikipedia:Interleukin-3_receptor is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019978 ! interleukin-3 binding [Term] id: GO:0004913 name: interleukin-4 receptor activity namespace: molecular_function def: "Combining with interleukin-4 to initiate a change in cell activity." [GOC:jl] synonym: "IL-4 receptor activity" EXACT [GOC:mah] synonym: "IL-4R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019979 ! interleukin-4 binding [Term] id: GO:0004914 name: interleukin-5 receptor activity namespace: molecular_function def: "Combining with interleukin-5 to initiate a change in cell activity." [GOC:jl] synonym: "IL-5 receptor activity" EXACT [GOC:mah] synonym: "IL-5R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019980 ! interleukin-5 binding [Term] id: GO:0004915 name: interleukin-6 receptor activity namespace: molecular_function def: "Combining with interleukin-6 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" NARROW [] synonym: "IL-6 receptor activity" EXACT [GOC:mah] synonym: "IL-6R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019981 ! interleukin-6 binding [Term] id: GO:0004917 name: interleukin-7 receptor activity namespace: molecular_function def: "Combining with interleukin-7 to initiate a change in cell activity." [GOC:jl] synonym: "IL-7 receptor activity" EXACT [GOC:mah] synonym: "IL-7R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019982 ! interleukin-7 binding [Term] id: GO:0004918 name: interleukin-8 receptor activity namespace: molecular_function def: "Combining with interleukin-8 to initiate a change in cell activity." [GOC:jl] synonym: "IL-8 receptor activity" EXACT [GOC:mah] synonym: "IL-8R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0016494 ! C-X-C chemokine receptor activity is_a: GO:0019959 ! interleukin-8 binding [Term] id: GO:0004919 name: interleukin-9 receptor activity namespace: molecular_function def: "Combining with interleukin-9 to initiate a change in cell activity." [GOC:jl] synonym: "IL-9 receptor activity" EXACT [GOC:mah] synonym: "IL-9R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019983 ! interleukin-9 binding [Term] id: GO:0004920 name: interleukin-10 receptor activity namespace: molecular_function def: "Combining with interleukin-10 to initiate a change in cell activity." [GOC:jl] synonym: "IL-10 receptor activity" EXACT [GOC:mah] synonym: "IL-10R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019969 ! interleukin-10 binding [Term] id: GO:0004921 name: interleukin-11 receptor activity namespace: molecular_function def: "Combining with interleukin-11 to initiate a change in cell activity." [GOC:jl] synonym: "gp130" NARROW [] synonym: "IL-11 receptor activity" EXACT [GOC:mah] synonym: "IL-11R" EXACT [] is_a: GO:0004896 ! cytokine receptor activity is_a: GO:0019970 ! interleukin-11 binding [Term] id: GO:0004923 name: leukemia inhibitory factor receptor activity namespace: molecular_function alt_id: GO:0004899 def: "Combining with leukemia inhibitory factor to initiate a change in cell activity." [GOC:mah] synonym: "leukemia inhibitory factor receptor beta-protein activity" NARROW [GOC:mah] synonym: "LIF receptor activity" EXACT [GOC:mah] is_a: GO:0004897 ! ciliary neurotrophic factor receptor activity is_a: GO:0005062 ! hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity [Term] id: GO:0004924 name: oncostatin-M receptor activity namespace: molecular_function def: "Combining with oncostatin-M to initiate a change in cell activity." [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004925 name: prolactin receptor activity namespace: molecular_function def: "Combining with prolactin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004896 ! cytokine receptor activity [Term] id: GO:0004926 name: non-G-protein coupled 7TM receptor activity namespace: molecular_function subset: gosubset_prok synonym: "non G protein coupled 7TM receptor activity" EXACT [] synonym: "non-G-protein-coupled 7TM receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004927 name: sevenless receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true consider: GO:0004714 consider: GO:0004926 consider: GO:0008288 [Term] id: GO:0004928 name: frizzled receptor activity namespace: molecular_function def: "OBSOLETE. Combining with a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true replaced_by: GO:0042813 consider: GO:0016055 [Term] id: GO:0004929 name: frizzled-2 receptor activity namespace: molecular_function def: "OBSOLETE. Combining with to a member of the Wnt-family of signaling molecules to initiate a change in cell activity." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product rather than an activity. is_obsolete: true replaced_by: GO:0042813 consider: GO:0007223 [Term] id: GO:0004930 name: G-protein coupled receptor activity namespace: molecular_function alt_id: GO:0016526 def: "A receptor that binds an extracellular ligand and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph, GOC:tb, http://www.iuphar-db.org] subset: gosubset_prok synonym: "G protein coupled receptor activity" EXACT [] synonym: "G protein linked receptor activity" EXACT [] synonym: "G-protein coupled receptor activity, unknown ligand" EXACT [] synonym: "G-protein linked receptor activity" EXACT [] synonym: "G-protein-coupled receptor activity" EXACT [] synonym: "GPCR activity" EXACT [] synonym: "ligand-dependent GPCR activity" EXACT [] synonym: "orphan G protein coupled receptor activity" EXACT [] synonym: "orphan G-protein coupled receptor activity" EXACT [] synonym: "orphan GPCR activity" EXACT [] xref: Reactome:35 "G-protein coupled receptor activity" is_a: GO:0004888 ! transmembrane receptor activity relationship: part_of GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0004931 name: extracellular ATP-gated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when extracellular ATP has been bound by the channel complex or one of its constituent parts." [GOC:bf, GOC:mah, PMID:9755289] comment: Note that this term refers to an activity and not a gene product. Consider also annotating to the molecular function term 'purinergic nucleotide receptor activity ; GO:0001614'. synonym: "P2X activity" RELATED [] synonym: "purinoceptor" BROAD [] synonym: "purinoreceptor" BROAD [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity is_a: GO:0035381 ! ATP-gated ion channel activity [Term] id: GO:0004932 name: mating-type factor pheromone receptor activity namespace: molecular_function def: "Combining with a mating-type factor pheromone to initiate a change in cell activity." [GOC:dph] subset: gosubset_prok is_a: GO:0016503 ! pheromone receptor activity [Term] id: GO:0004933 name: mating-type a-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type a-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity [Term] id: GO:0004934 name: mating-type alpha-factor pheromone receptor activity namespace: molecular_function def: "Combining with the mating-type alpha-factor pheromone to initiate a change in cell activity." [GOC:mah] synonym: "class D G protein coupled receptor activity" BROAD [] synonym: "class D G-protein coupled receptor activity" BROAD [] synonym: "class D G-protein-coupled receptor activity" BROAD [] synonym: "class D GPCR activity" BROAD [] is_a: GO:0004932 ! mating-type factor pheromone receptor activity [Term] id: GO:0004935 name: adrenoceptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity." [GOC:mah, IUPHAR_GPCR:1274] synonym: "adrenergic receptor" EXACT [] xref: Wikipedia:Adrenergic_receptor is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004936 name: alpha-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenoceptor activity [Term] id: GO:0004937 name: alpha1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha1-adrenergic receptors; the activity involves transmitting the signal to the Gq alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha1 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004938 name: alpha2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of alpha2-adrenergic receptors; the activity involves transmitting the signal to the Gi alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "alpha2 adrenoceptor" EXACT [] is_a: GO:0004936 ! alpha-adrenergic receptor activity [Term] id: GO:0004939 name: beta-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein." [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] synonym: "beta adrenoceptor" EXACT [] is_a: GO:0004935 ! adrenoceptor activity [Term] id: GO:0004940 name: beta1-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta1-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta1 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004941 name: beta2-adrenergic receptor activity namespace: molecular_function def: "Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta2-adrenergic receptors." [GOC:mah, IUPHAR_GPCR:1274] synonym: "beta2 adrenoceptor" EXACT [] is_a: GO:0004939 ! beta-adrenergic receptor activity [Term] id: GO:0004942 name: anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004943 name: C3a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C3a to initiate a change in cell activity." [GOC:mah] is_a: GO:0004942 ! anaphylatoxin receptor activity [Term] id: GO:0004944 name: C5a anaphylatoxin receptor activity namespace: molecular_function def: "Combining with anaphylatoxin C5a to initiate a change in cell activity." [GOC:mah] is_a: GO:0004942 ! anaphylatoxin receptor activity [Term] id: GO:0004945 name: angiotensin type II receptor activity namespace: molecular_function is_a: GO:0001595 ! angiotensin receptor activity [Term] id: GO:0004946 name: bombesin receptor activity namespace: molecular_function def: "Combining with bombesin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity relationship: part_of GO:0031989 ! bombesin receptor signaling pathway [Term] id: GO:0004947 name: bradykinin receptor activity namespace: molecular_function def: "Combining with bradykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004948 name: calcitonin receptor activity namespace: molecular_function def: "Combining with calcitonin to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004949 name: cannabinoid receptor activity namespace: molecular_function def: "Combining with cannabinoids to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1279] synonym: "cannaboid receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004950 name: chemokine receptor activity namespace: molecular_function def: "Combining with chemokines, small chemoattractant molecules normally used to stimulate leukocytes, to initiate a change in cell activity." [IUPHAR_GPCR:1280, PMID:8662823] is_a: GO:0001637 ! G-protein chemoattractant receptor activity is_a: GO:0019956 ! chemokine binding [Term] id: GO:0004951 name: cholecystokinin receptor activity namespace: molecular_function def: "Combining with a cholecystokinin, any of a group of related neuropeptides secreted by the upper intestinal mucosa and also found in the central nervous system, to initiate a change in cell activity." [GOC:ai, GOC:mah, http://cancerweb.ncl.ac.uk/] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004952 name: dopamine receptor activity namespace: molecular_function def: "Combining with the neurotransmitter dopamine to initiate a change in cell activity." [IUPHAR_GPCR:1282] is_a: GO:0008227 ! G-protein coupled amine receptor activity is_a: GO:0035240 ! dopamine binding [Term] id: GO:0004953 name: icosanoid receptor activity namespace: molecular_function def: "Combining with an icosanoid to initiate a change in cell activity." [GOC:dph] synonym: "eicosanoid receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004954 name: prostanoid receptor activity namespace: molecular_function def: "Combining with a prostanoid, any compound based on or derived from the prostanoate structure, to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004953 ! icosanoid receptor activity [Term] id: GO:0004955 name: prostaglandin receptor activity namespace: molecular_function def: "Combining with a prostaglandin (PG) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004956 name: prostaglandin D receptor activity namespace: molecular_function def: "Combining with prostaglandin D (PGD(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGD receptor activity" RELATED [] synonym: "PGD(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004957 name: prostaglandin E receptor activity namespace: molecular_function def: "Combining with prostaglandin E (PGE(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGE receptor activity" RELATED [] synonym: "PGE(2) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004958 name: prostaglandin F receptor activity namespace: molecular_function def: "Combining with prostaglandin F (PGF (2-alpha)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "PGF receptor activity" RELATED [] synonym: "PGF(2-alpha) receptor activity" EXACT [] is_a: GO:0004955 ! prostaglandin receptor activity [Term] id: GO:0004960 name: thromboxane receptor activity namespace: molecular_function def: "Combining with a thromboxane (TXA) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA receptor activity" EXACT [] is_a: GO:0004954 ! prostanoid receptor activity [Term] id: GO:0004961 name: thromboxane A2 receptor activity namespace: molecular_function def: "Combining with thromboxane A2 (TXA(2)) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "TXA(2) receptor activity" EXACT [] is_a: GO:0004960 ! thromboxane receptor activity [Term] id: GO:0004962 name: endothelin receptor activity namespace: molecular_function def: "Combining with endothelin to initiate a change in cell activity." [GOC:dph, IUPHAR_GPCR:1283] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004963 name: follicle-stimulating hormone receptor activity namespace: molecular_function def: "Combining with follicle-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "follicle stimulating hormone receptor activity" EXACT [] synonym: "FSH receptor activity" EXACT [] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004964 name: luteinizing hormone receptor activity namespace: molecular_function alt_id: GO:0004976 def: "Combining with luteinizing hormone (also called lutropin) to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:18848524, PMID:1922095] synonym: "LH receptor" EXACT [PMID:18848524] synonym: "LHR" EXACT [PMID:18848524] synonym: "lutropin receptor" EXACT [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lutropin-choriogonadotropic hormone receptor" RELATED [PMID:1922095] is_a: GO:0016500 ! protein-hormone receptor activity relationship: part_of GO:0042700 ! luteinizing hormone signaling pathway [Term] id: GO:0004965 name: GABA-B receptor activity namespace: molecular_function def: "Combining with the amino acid gamma-aminobutyric acid (GABA, 4-aminobutyrate) to initiate a change in cell activity. GABA-B receptors are G-protein coupled receptors." [GOC:ai, IUPHAR_RECEPTOR:1276] is_a: GO:0008066 ! glutamate receptor activity is_a: GO:0016917 ! GABA receptor activity [Term] id: GO:0004966 name: galanin receptor activity namespace: molecular_function def: "Combining with galanin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004967 name: glucagon receptor activity namespace: molecular_function def: "Combining with glucagon to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004968 name: gonadotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with gonadotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004969 name: histamine receptor activity namespace: molecular_function def: "Combining with histamine to initiate a change in cell activity. Histamine is a physiologically active amine, found in plant and animal tissue and released from mast cells as part of an allergic reaction in humans." [GOC:ai] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004970 name: ionotropic glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity through the regulation of ion channels." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'glutamate-gated ion channel activity ; GO:0005234' and 'cation channel activity ; GO:0005261'. subset: gosubset_prok is_a: GO:0008066 ! glutamate receptor activity [Term] id: GO:0004971 name: alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. is_a: GO:0004970 ! ionotropic glutamate receptor activity [Term] id: GO:0004972 name: N-methyl-D-aspartate selective glutamate receptor activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'ionotropic glutamate receptor activity ; GO:0004970' and 'cation channel activity ; GO:0005261'. synonym: "NMDA receptor" EXACT [] xref: Wikipedia:NMDA_receptor is_a: GO:0004970 ! ionotropic glutamate receptor activity [Term] id: GO:0004973 name: N-methyl-D-aspartate receptor-associated protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005102 consider: GO:0005515 [Term] id: GO:0004974 name: leukotriene receptor activity namespace: molecular_function def: "Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide moiety based on cysteine." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004977 name: melanocortin receptor activity namespace: molecular_function def: "Combining with melanocortin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004978 name: adrenocorticotropin receptor activity namespace: molecular_function def: "Combining with adrenocorticotropin to initiate a change in cell activity." [GOC:ai] synonym: "ACTH receptor activity" EXACT [] synonym: "adrenocorticotropic hormone receptor activity" EXACT [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity is_a: GO:0042562 ! hormone binding [Term] id: GO:0004979 name: beta-endorphin receptor activity namespace: molecular_function def: "Combining with beta-endorphin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004980 name: melanocyte-stimulating hormone receptor activity namespace: molecular_function def: "Combining with melanocyte-stimulating hormone to initiate a change in cell activity." [GOC:jl, PMID:7581459] synonym: "melanocyte stimulating hormone receptor activity" EXACT [] synonym: "melanophore-stimulating hormone receptor activity" EXACT [] synonym: "MSH receptor activity" BROAD [] synonym: "MSHR activity" BROAD [] is_a: GO:0004977 ! melanocortin receptor activity is_a: GO:0042562 ! hormone binding [Term] id: GO:0004981 name: muscarinic acetylcholine receptor activity namespace: molecular_function def: "Combining with acetylcholine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of muscarinic receptors." [GOC:mah, IUPHAR_GPCR:1271] is_a: GO:0016907 ! G-protein coupled acetylcholine receptor activity relationship: part_of GO:0007213 ! muscarinic acetylcholine receptor signaling pathway [Term] id: GO:0004982 name: N-formyl peptide receptor activity namespace: molecular_function def: "Combining with an N-formyl peptide to initiate a change in cell activity." [GOC:ai] synonym: "Fmet-leu-phe receptor" EXACT [] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004983 name: neuropeptide Y receptor activity namespace: molecular_function def: "Combining with neuropeptide Y to initiate a change in cell activity." [PMID:9315606] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004984 name: olfactory receptor activity namespace: molecular_function def: "Combining with airborne compounds to initiate a change in cell activity. These receptors are used for the sense of smell." [GOC:dph] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004985 name: opioid receptor activity namespace: molecular_function def: "Combining with an opioid, any narcotic derived from or resembling opium, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004986 name: delta-opioid receptor activity namespace: molecular_function is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004987 name: kappa-opioid receptor activity namespace: molecular_function is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004988 name: mu-opioid receptor activity namespace: molecular_function is_a: GO:0004985 ! opioid receptor activity [Term] id: GO:0004989 name: octopamine receptor activity namespace: molecular_function def: "Combining with the biogenic amine octopamine to initiate a change in cell activity. Octopamine is found in both vertebrates and invertebrates and can have properties both of a hormone and a neurotransmitter and acts as an adrenergic agonist." [GOC:ai, http://cancerweb.ncl.ac.uk/] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004990 name: oxytocin receptor activity namespace: molecular_function def: "Combining with oxytocin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0004991 name: parathyroid hormone receptor activity namespace: molecular_function def: "Combining with parathyroid hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004992 name: platelet activating factor receptor activity namespace: molecular_function def: "Combining with platelet activating factor to initiate a change in cell activity." [GOC:mah] synonym: "PAF receptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004993 name: serotonin receptor activity namespace: molecular_function alt_id: GO:0001585 def: "Combining with the biogenic amine serotonin, a neurotransmitter and hormone found in vertebrates, invertebrates and plants, to initiate a change in cell activity." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "5-HT receptor" EXACT [] synonym: "5-hydroxytryptamine receptor" EXACT [] xref: Wikipedia:5-HT_receptor is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0004994 name: somatostatin receptor activity namespace: molecular_function def: "Combining with somatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity [Term] id: GO:0004995 name: tachykinin receptor activity namespace: molecular_function def: "Combining with tachykinin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008188 ! neuropeptide receptor activity relationship: part_of GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0004996 name: thyroid-stimulating hormone receptor activity namespace: molecular_function def: "Combining with thyroid-stimulating hormone to initiate a change in cell activity." [GOC:mah] synonym: "thyroid stimulating hormone receptor activity" EXACT [] synonym: "thyrotropin receptor" EXACT [] synonym: "TSH receptor activity" EXACT [] xref: Wikipedia:Thyrotropin_receptor is_a: GO:0016500 ! protein-hormone receptor activity [Term] id: GO:0004997 name: thyrotropin-releasing hormone receptor activity namespace: molecular_function def: "Combining with thyrotropin-releasing hormone to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0004998 name: transferrin receptor activity namespace: molecular_function def: "Combining with transferrin to initiate a change in cell activity." [GOC:mah] subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0004999 name: vasoactive intestinal polypeptide receptor activity namespace: molecular_function def: "Combining with vasoactive intestinal polypeptide to initiate a change in cell activity." [GOC:mah] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0005000 name: vasopressin receptor activity namespace: molecular_function def: "Combining with vasopressin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0005001 name: transmembrane receptor protein tyrosine phosphatase activity namespace: molecular_function is_a: GO:0004725 ! protein tyrosine phosphatase activity is_a: GO:0019198 ! transmembrane receptor protein phosphatase activity [Term] id: GO:0005003 name: ephrin receptor activity namespace: molecular_function def: "Combining with an ephrin to initiate a change in cell activity." [GOC:mah] synonym: "Eph receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005004 name: GPI-linked ephrin receptor activity namespace: molecular_function synonym: "GPI-linked Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005005 name: transmembrane-ephrin receptor activity namespace: molecular_function synonym: "transmembrane-Eph receptor activity" EXACT [] is_a: GO:0005003 ! ephrin receptor activity [Term] id: GO:0005006 name: epidermal growth factor receptor activity namespace: molecular_function alt_id: GO:0005023 def: "Combining with an epidermal growth factor to initiate a change in cell activity." [GOC:bf] subset: gosubset_prok synonym: "EGF receptor activity" EXACT [] synonym: "EGFR" EXACT [] synonym: "TGF-alpha receptor activity" EXACT [] synonym: "transforming growth factor-alpha receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0005007 name: fibroblast growth factor receptor activity namespace: molecular_function def: "Combining with fibroblast growth factor to initiate a change in cell activity." [GOC:mah] synonym: "FGF receptor activity" EXACT [] synonym: "FGFR" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0008543 ! fibroblast growth factor receptor signaling pathway [Term] id: GO:0005008 name: hepatocyte growth factor receptor activity namespace: molecular_function def: "Combining with hepatocye growth factor to initiate a change in cell activity." [GOC:mah] synonym: "HGF receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0048012 ! hepatocyte growth factor receptor signaling pathway [Term] id: GO:0005009 name: insulin receptor activity namespace: molecular_function def: "Combining with insulin to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0008286 ! insulin receptor signaling pathway [Term] id: GO:0005010 name: insulin-like growth factor receptor activity namespace: molecular_function def: "Combining with an insulin-like growth factor to initiate a change in cell activity." [GOC:mah] synonym: "IGF receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0048009 ! insulin-like growth factor receptor signaling pathway [Term] id: GO:0005011 name: macrophage colony-stimulating factor receptor activity namespace: molecular_function def: "Combining with macrophage colony-stimulating factor to initiate a change in cell activity." [GOC:mah] synonym: "CSF-1" NARROW [] synonym: "Fms" NARROW [] synonym: "macrophage colony stimulating factor receptor activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005012 name: Neu/ErbB-2 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a class of receptor rather than an activity. is_obsolete: true consider: GO:0043125 [Term] id: GO:0005013 name: neurotrophin TRK receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0019838 consider: GO:0043121 [Term] id: GO:0005014 name: neurotrophin TRKA receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048404 consider: GO:0048406 [Term] id: GO:0005015 name: neurotrophin TRKB receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048403 consider: GO:0048404 consider: GO:0048405 [Term] id: GO:0005016 name: neurotrophin TRKC receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jid] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0004714 consider: GO:0007165 consider: GO:0048404 [Term] id: GO:0005017 name: platelet-derived growth factor receptor activity namespace: molecular_function def: "Combining with platelet-derived growth factor to initiate a change in cell activity." [GOC:mah] synonym: "PDGF receptor activity" EXACT [] synonym: "PDGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0048008 ! platelet-derived growth factor receptor signaling pathway [Term] id: GO:0005018 name: platelet-derived growth factor alpha-receptor activity namespace: molecular_function synonym: "PDGF alpha-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor receptor activity [Term] id: GO:0005019 name: platelet-derived growth factor beta-receptor activity namespace: molecular_function synonym: "PDGF beta-receptor activity" EXACT [] is_a: GO:0005017 ! platelet-derived growth factor receptor activity [Term] id: GO:0005020 name: stem cell factor receptor activity namespace: molecular_function def: "Combining with stem cell factor, a cytokine that stimulates mast cell growth and differentiation, to initiate a change in cell activity." [GOC:jl, PMID:10698217] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0005021 name: vascular endothelial growth factor receptor activity namespace: molecular_function def: "Combining with vascular endothelial growth factor to initiate a change in cell activity." [GOC:mah] synonym: "VEGF receptor activity" EXACT [] synonym: "VEGFR activity" EXACT [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity relationship: part_of GO:0048010 ! vascular endothelial growth factor receptor signaling pathway [Term] id: GO:0005024 name: transforming growth factor beta receptor activity namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity." [GOC:mah] synonym: "TGF-beta receptor activity" EXACT [] synonym: "TGFbeta receptor activity" EXACT [] synonym: "TGFbetaR" EXACT [] is_a: GO:0004675 ! transmembrane receptor protein serine/threonine kinase activity [Term] id: GO:0005025 name: transforming growth factor beta receptor activity, type I namespace: molecular_function def: "Combining with a complex of transforming growth factor beta and a type II TGF-beta receptor to initiate a change in cell activity." [GOC:mah, Reactome:REACT_6945.1] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "type I TGF-beta receptor activity" EXACT [] synonym: "type I TGFbeta receptor activity" EXACT [] synonym: "type I transforming growth factor beta receptor activity" EXACT [] is_a: GO:0005024 ! transforming growth factor beta receptor activity [Term] id: GO:0005026 name: transforming growth factor beta receptor activity, type II namespace: molecular_function def: "Combining with transforming growth factor beta to initiate a change in cell activity; upon ligand binding, binds to and catalyzes the phosphorylation of a type I TGF-beta receptor." [GOC:mah, Reactome:REACT_6872.1] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "type II TGF-beta receptor activity" EXACT [] synonym: "type II TGFbeta receptor activity" EXACT [] synonym: "type II transforming growth factor beta receptor activity" EXACT [] xref: Reactome:11166 "transforming growth factor beta receptor activity, type II" is_a: GO:0005024 ! transforming growth factor beta receptor activity [Term] id: GO:0005027 name: NGF/TNF (6 C-domain) receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a protein family rather than a molecular function. is_obsolete: true consider: GO:0005031 [Term] id: GO:0005028 name: CD40 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0042615 [Term] id: GO:0005029 name: CD27 receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it describes the receptor type, and not an activity. is_obsolete: true consider: GO:0042614 [Term] id: GO:0005030 name: neurotrophin receptor activity namespace: molecular_function def: "Combining with neurotrophin, any of a family of growth factors that block apoptosis in neurons and thus promote nerve growth, to initiate a change in cell activity." [GOC:jl, http://www.mercksource.com/] is_a: GO:0004872 ! receptor activity is_a: GO:0043121 ! neurotrophin binding [Term] id: GO:0005031 name: tumor necrosis factor receptor activity namespace: molecular_function alt_id: GO:0005032 alt_id: GO:0005033 def: "Combining with tumor necrosis factor, a proinflammatory cytokine produced by monocytes and macrophages, to initiate a change in cell function." [GOC:jl, http://lookwayup.com/] synonym: "NGF/TNF (6 C-domain) receptor activity" NARROW [] synonym: "TNF receptor activity" EXACT [] synonym: "TNF receptor activity, type I" NARROW [] synonym: "TNF receptor activity, type II" NARROW [] synonym: "tumor necrosis factor receptor activity, type I" NARROW [] synonym: "tumor necrosis factor receptor activity, type II" NARROW [] is_a: GO:0005035 ! death receptor activity is_a: GO:0043120 ! tumor necrosis factor binding relationship: part_of GO:0033209 ! tumor necrosis factor-mediated signaling pathway [Term] id: GO:0005034 name: osmosensor activity namespace: molecular_function def: "Sensing extracellular osmolarity to initiate a change in cell activity, and spanning the membrane of the cell." [GOC:dph, GOC:tb] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005035 name: death receptor activity namespace: molecular_function is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005037 name: death receptor adaptor protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005038 name: death receptor interacting protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005039 name: death receptor-associated factor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0005123 consider: GO:0005515 [Term] id: GO:0005040 name: decoy death receptor activity namespace: molecular_function is_a: GO:0005035 ! death receptor activity [Term] id: GO:0005041 name: low-density lipoprotein receptor activity namespace: molecular_function alt_id: GO:0008032 def: "Combining with a low-density lipoprotein to initiate a change in cell activity." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "LDL receptor" EXACT [] xref: Wikipedia:LDL_receptor is_a: GO:0030169 ! low-density lipoprotein binding is_a: GO:0030228 ! lipoprotein receptor activity [Term] id: GO:0005042 name: netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemotaxis when activated." [GOC:dph] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005043 name: repulsive netrin receptor activity namespace: molecular_function def: "A transmembrane receptor activity that responds to the netrin family of ligands and results in chemorepulsion when activated." [GOC:dph] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005044 name: scavenger receptor activity namespace: molecular_function def: "Combining with acetylated low-density lipoproteins, advanced glycation end products, or other polyanionic ligands to initiate a change in cell activity." [PMID:11790542, PMID:12379907, PMID:12621157] comment: Note that many gene products that are called scavenger receptors have a broad range of potential ligands and also can be annotated to 'pattern recognition receptor activity ; GO:0008329' or its child terms, or to 'lipoprotein receptor activity ; GO:0030228' or its child terms. subset: gosubset_prok synonym: "macrophage receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005045 name: endoplasmic reticulum receptor activity namespace: molecular_function def: "OBSOLETE. A receptor in the endoplasmic reticulum." [GOC:ai] comment: This term was made obsolete because it represents cellular component and molecular function information. is_obsolete: true replaced_by: GO:0004872 replaced_by: GO:0005783 [Term] id: GO:0005046 name: KDEL sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a KDEL sequence, the C terminus tetrapeptide sequence Lys-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum." [GOC:ai] synonym: "KDEL receptor activity" NARROW [] is_a: GO:0046923 ! ER retention sequence binding [Term] id: GO:0005047 name: signal recognition particle binding namespace: molecular_function def: "Interacting selectively and non-covalently with the signal recognition particle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the cellular component term 'signal recognition particle, endoplasmic reticulum targeting ; GO:0005786'. subset: gosubset_prok synonym: "docking protein" BROAD [] synonym: "signal recognition particle receptor" NARROW [] xref: Reactome:11266 "signal recognition particle binding" is_a: GO:0043021 ! ribonucleoprotein binding [Term] id: GO:0005048 name: signal sequence binding namespace: molecular_function alt_id: GO:0008249 def: "Interacting selectively and non-covalently with a signal sequence, a specific peptide sequence found on protein precursors or mature proteins that dictates where the mature protein is localized." [GOC:ai] subset: gosubset_prok synonym: "leader sequence binding" NARROW [] synonym: "protein signal sequence binding" NARROW [] synonym: "signal sequence receptor" NARROW [] xref: Reactome:11268 "signal sequence binding" is_a: GO:0042277 ! peptide binding [Term] id: GO:0005049 name: nuclear export signal receptor activity namespace: molecular_function def: "Combining with a nuclear export signal to initiate a change in cell activity." [GOC:ai] synonym: "NES receptor" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005050 name: peroxisome receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. is_obsolete: true consider: GO:0004872 consider: GO:0005777 [Term] id: GO:0005052 name: peroxisome matrix targeting signal-1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 1 peroxisome targeting signal, a tripeptide with the consensus sequence (S/A/C)-(K/R/H)-L." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-1 binding" EXACT [] synonym: "peroxisome targeting signal-1 receptor" NARROW [] synonym: "PEX5" NARROW [] synonym: "PTS1 receptor" NARROW [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005053 name: peroxisome matrix targeting signal-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type 2 peroxisome targeting signal, a nonapeptide with a broad consensus sequence of (R/K)-(L/V/I)-(XXXXX)-(H/Q)-(L/A/F)." [GOC:mah, PMID:11687502] synonym: "peroxisome targeting signal-2 binding" EXACT [] synonym: "peroxisome targeting signal-2 receptor" NARROW [] synonym: "PEX7" NARROW [] synonym: "PTS2 receptor" EXACT [] is_a: GO:0000268 ! peroxisome targeting sequence binding [Term] id: GO:0005054 name: peroxisome integral membrane receptor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular component. synonym: "Pas20p" RELATED [] is_obsolete: true consider: GO:0004872 consider: GO:0005778 [Term] id: GO:0005055 name: laminin receptor activity namespace: molecular_function def: "Combining with a laminin, a glycoprotein that constitutes the majority of proteins in the basement membrane, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'cell adhesion molecule binding ; GO:0050839' and 'receptor binding ; GO:0005102' and the biological process term 'cell adhesion ; GO:0007155'. subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005056 name: tiggrin receptor activity namespace: molecular_function is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0005057 name: receptor signaling protein activity namespace: molecular_function synonym: "receptor signalling protein activity" EXACT [] is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0005061 name: aryl hydrocarbon receptor nuclear translocator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005062 name: hematopoietin/interferon-class (D200-domain) cytokine receptor signal transducer activity namespace: molecular_function synonym: "gp130" NARROW [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005065 name: heterotrimeric G-protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a cellular component and not a molecular function. is_obsolete: true replaced_by: GO:0005834 [Term] id: GO:0005066 name: transmembrane receptor protein tyrosine kinase signaling protein activity namespace: molecular_function synonym: "transmembrane receptor protein tyrosine kinase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005068 name: transmembrane receptor protein tyrosine kinase adaptor protein activity namespace: molecular_function def: "The binding activity of a molecule that brings together a transmembrane receptor protein kinase and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] xref: Reactome:11343 "transmembrane receptor protein tyrosine kinase adaptor protein activity" is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0005069 name: transmembrane receptor protein tyrosine kinase docking protein activity namespace: molecular_function is_a: GO:0005066 ! transmembrane receptor protein tyrosine kinase signaling protein activity [Term] id: GO:0005070 name: SH3/SH2 adaptor activity namespace: molecular_function def: "Interacting selectively and non-covalently and simultaneously with one or more signal transduction molecules, usually acting as a scaffold to bring these molecules into close proximity either using their own SH2/SH3 domains (e.g. Grb2) or those of their target molecules (e.g. SAM68)." [GOC:mah, GOC:so] synonym: "SH3/SH2 adaptor protein activity" NARROW [] is_a: GO:0004871 ! signal transducer activity is_a: GO:0030674 ! protein binding, bridging is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0005071 name: transmembrane receptor protein serine/threonine kinase signaling protein activity namespace: molecular_function synonym: "transmembrane receptor protein serine/threonine kinase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005072 name: transforming growth factor beta receptor, cytoplasmic mediator activity namespace: molecular_function def: "Activity of any of the molecules that transmit the signal from a TGF-beta receptor through the cytoplasm to the nucleus." [GOC:hjd] comment: Note that this term and its children are useful for annotating proteins of the SMAD family. synonym: "TGF-beta receptor, cytoplasmic mediator activity" EXACT [] synonym: "TGFbeta receptor, cytoplasmic mediator activity" EXACT [] is_a: GO:0005071 ! transmembrane receptor protein serine/threonine kinase signaling protein activity [Term] id: GO:0005073 name: common-partner SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. is_obsolete: true replaced_by: GO:0030616 [Term] id: GO:0005074 name: inhibitory SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it names a family of gene products. is_obsolete: true replaced_by: GO:0030617 [Term] id: GO:0005075 name: pathway-specific SMAD protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a family of gene products. is_obsolete: true replaced_by: GO:0030618 [Term] id: GO:0005076 name: receptor signaling protein serine/threonine kinase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine kinase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005077 name: MAP-kinase anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to MAP kinase and anchors it to a particular subcellular location." [GOC:ai] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "MAP-kinase anchor protein activity" EXACT [] is_obsolete: true replaced_by: GO:0008104 replaced_by: GO:0051019 [Term] id: GO:0005078 name: MAP-kinase scaffold activity namespace: molecular_function def: "Functions as a physical support for the assembly of a multiprotein mitogen-activated protein kinase (MAPK) complex. MAPK scaffold proteins have binding sites for MAPK pathway kinases as well as for upstream signaling proteins." [PMID:12511654] synonym: "MAP-kinase scaffold protein activity" EXACT [] is_a: GO:0030159 ! receptor signaling complex scaffold activity [Term] id: GO:0005079 name: protein kinase A anchoring activity namespace: molecular_function def: "OBSOLETE. Binds to protein kinase A and anchors it to a particular subcellular location." [PMID:10354567] comment: This term was made obsolete because it represents a combination of process and function information. synonym: "A-kinase anchor protein activity" EXACT [] synonym: "AKAP activity" EXACT [] is_obsolete: true replaced_by: GO:0008104 replaced_by: GO:0051018 [Term] id: GO:0005080 name: protein kinase C binding namespace: molecular_function def: "Interacting selectively and non-covalently with protein kinase C." [GOC:jl] synonym: "PKC binding" EXACT [] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0005081 name: receptor signaling protein serine/threonine phosphatase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine phosphatase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005082 name: receptor signaling protein tyrosine phosphatase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein tyrosine phosphatase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0005083 name: small GTPase regulator activity namespace: molecular_function def: "Modulates the rate of GTP hydrolysis by a small monomeric GTPase." [GOC:mah] subset: gosubset_prok synonym: "small GTPase regulatory/interacting protein activity" RELATED [] is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005085 name: guanyl-nucleotide exchange factor activity namespace: molecular_function alt_id: GO:0008433 alt_id: GO:0019839 def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:kd, GOC:mah] subset: gosubset_prok synonym: "GEF" EXACT [] synonym: "GNRP" NARROW [] synonym: "guanyl-nucleotide release factor activity" EXACT [] synonym: "guanyl-nucleotide releasing factor" EXACT [] xref: Reactome:11431 "guanyl-nucleotide exchange factor activity" is_a: GO:0030695 ! GTPase regulator activity [Term] id: GO:0005086 name: ARF guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with the GTPase ARF. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:11434 "ARF guanyl-nucleotide exchange factor activity" is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005087 name: Ran guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ran family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "RCC1" EXACT [] xref: Reactome:11435 "Ran guanyl-nucleotide exchange factor activity" xref: Wikipedia:RCC1 is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0005088 name: Ras guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ras superfamily. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:11436 "Ras guanyl-nucleotide exchange factor activity" is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005089 name: Rho guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Rho family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] synonym: "Rho guanine nucleotide exchange factor" EXACT [] synonym: "RhoGEF" EXACT [] xref: Reactome:11437 "Rho guanyl-nucleotide exchange factor activity" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0005090 name: Sar guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Sar family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005085 ! guanyl-nucleotide exchange factor activity [Term] id: GO:0005091 name: guanyl-nucleotide exchange factor adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a guanyl-nucleotide exchange factor and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0005092 name: GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from a GTPase, thereby preventing GTP from binding." [GOC:mah] synonym: "GDI" EXACT [] is_a: GO:0005083 ! small GTPase regulator activity relationship: positively_regulates GO:0019003 ! GDP binding [Term] id: GO:0005093 name: Rab GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rab, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005094 name: Rho GDP-dissociation inhibitor activity namespace: molecular_function def: "Prevents the dissociation of GDP from the small GTPase Rho, thereby preventing GTP from binding." [GOC:mah] is_a: GO:0005092 ! GDP-dissociation inhibitor activity [Term] id: GO:0005095 name: GTPase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of any enzyme that catalyzes the hydrolysis of GTP to GDP and orthophosphate." [GOC:ai] synonym: "GIP" BROAD [] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0030695 ! GTPase regulator activity relationship: negatively_regulates GO:0003924 ! GTPase activity [Term] id: GO:0005096 name: GTPase activator activity namespace: molecular_function def: "Increases the activity of a GTPase, an enzyme that catalyzes the hydrolysis of GTP." [GOC:mah] subset: gosubset_prok synonym: "GAP activity" EXACT [] xref: Reactome:11473 "GTPase activator activity" is_a: GO:0008047 ! enzyme activator activity is_a: GO:0030695 ! GTPase regulator activity relationship: positively_regulates GO:0003924 ! GTPase activity [Term] id: GO:0005097 name: Rab GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rab family." [GOC:mah] synonym: "Rab GAP activity" EXACT [GOC:pg] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005098 name: Ran GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ran family." [GOC:mah] synonym: "Ran GAP activity" EXACT [GOC:pg] synonym: "RanGAP" RELATED [] is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005099 name: Ras GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Ras superfamily." [GOC:mah] synonym: "Ras GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0005100 name: Rho GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Rho family." [GOC:mah] synonym: "Rho GAP activity" EXACT [GOC:pg] xref: Reactome:12052 "Rho GTPase activator activity" is_a: GO:0005099 ! Ras GTPase activator activity [Term] id: GO:0005101 name: Sar GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by a GTPase of the Sar family." [GOC:mah] comment: Note that the name Sar derives from 'secretion-associated, Ras-related'. synonym: "Sar GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0005102 name: receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with one or more specific sites on a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function." [GOC:bf, GOC:ceb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "receptor ligand" NARROW [] synonym: "receptor-associated protein activity" RELATED [] xref: Wikipedia:Ligand_(biochemistry) is_a: GO:0005515 ! protein binding [Term] id: GO:0005104 name: fibroblast growth factor receptor binding namespace: molecular_function alt_id: GO:0001521 alt_id: GO:0005162 def: "Interacting selectively and non-covalently with the fibroblast growth factor receptor (FGFR)." [GOC:ceb] comment: Note that branchless is the Drosophila gene encoding fibroblast growth factor. synonym: "FGF receptor binding" EXACT [] synonym: "FGFR binding" EXACT [] synonym: "FGFR ligand" NARROW [] synonym: "fibroblast growth factor" BROAD [] synonym: "fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005105 name: type 1 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 1 fibroblast growth factor receptor (FGFR1)." [GOC:ceb, GOC:fb_curators] comment: Note that breathless is the Drosophila gene encoding the type 1 fibroblast growth factor receptor (FGFR1). synonym: "breathless binding" NARROW [] synonym: "breathless ligand" NARROW [] synonym: "FGFR1 binding" BROAD [] synonym: "FGFR1 ligand" NARROW [] synonym: "type 1 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005106 name: ephrin namespace: molecular_function def: "OBSOLETE. A class of proteins that interact with the ephrin receptors." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0046875 [Term] id: GO:0005107 name: GPI-linked ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0046658 consider: GO:0046875 [Term] id: GO:0005108 name: transmembrane ephrin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005887 consider: GO:0046875 [Term] id: GO:0005109 name: frizzled binding namespace: molecular_function def: "Interacting selectively and non-covalently with the frizzled (fz) receptor." [GOC:ceb] synonym: "frizzled ligand" NARROW [] synonym: "fz binding" EXACT [] synonym: "fz ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0005110 name: frizzled-2 binding namespace: molecular_function def: "Interacting selectively and non-covalently with frizzled-2 (fz2)." [GOC:ceb] synonym: "frizzled-2 ligand" NARROW [] synonym: "fz2 binding" EXACT [] synonym: "fz2 ligand" NARROW [] is_a: GO:0001664 ! G-protein-coupled receptor binding [Term] id: GO:0005111 name: type 2 fibroblast growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the type 2 fibroblast growth factor receptor (FGFR2)." [GOC:fb_curators] comment: Note that heartless is the Drosophila gene encoding the type 2 fibroblast growth factor receptor (FGFR2). synonym: "FGFR2 binding" EXACT [] synonym: "FGFR2 ligand" NARROW [] synonym: "heartless binding" EXACT [] synonym: "heartless ligand" NARROW [] synonym: "type 2 fibroblast growth factor receptor ligand" NARROW [] is_a: GO:0005104 ! fibroblast growth factor receptor binding [Term] id: GO:0005112 name: Notch binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Notch (N) protein, a surface receptor." [GOC:ceb] synonym: "N binding" EXACT [] synonym: "N ligand" NARROW [] synonym: "Notch ligand" NARROW [] synonym: "Notch receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005113 name: patched binding namespace: molecular_function def: "Interacting selectively and non-covalently with the patched (ptc) protein, a receptor for hedgehog proteins." [GOC:ceb, PMID:11731473] synonym: "patched ligand" NARROW [] synonym: "ptc binding" EXACT [] synonym: "ptc ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005114 name: type II transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a type II transforming growth factor beta receptor." [GOC:ceb, GOC:mah, PMID:11252892] synonym: "punt binding" NARROW [] synonym: "punt ligand" NARROW [] synonym: "TGF-beta type II binding" EXACT [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor type II binding" EXACT [] synonym: "type II TGF-beta binding" EXACT [] is_a: GO:0005160 ! transforming growth factor beta receptor binding [Term] id: GO:0005115 name: receptor tyrosine kinase-like orphan receptor binding namespace: molecular_function def: "Interaction with the receptor tyrosine kinase-like orphan receptor (Ror)." [GOC:ceb] synonym: "receptor tyrosine kinase-like orphan receptor ligand" NARROW [] synonym: "Ror binding" BROAD [] synonym: "Ror ligand" RELATED [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005117 name: wishful thinking binding namespace: molecular_function def: "Interacting selectively and non-covalently with wishful thinking (Wit), a type II bone morphogenic protein receptor." [GOC:ceb, PMID:11856529] synonym: "SE20 receptor binding" NARROW [] synonym: "wishful thinking ligand" NARROW [] synonym: "Wit binding" EXACT [] synonym: "Wit ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005118 name: sevenless binding namespace: molecular_function def: "Interacting selectively and non-covalently with the sevenless (sev) protein, a receptor tyrosine kinase." [FB:gn0003366, GOC:ceb] synonym: "sev binding" EXACT [] synonym: "sev ligand" NARROW [] synonym: "sevenless ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005119 name: smoothened binding namespace: molecular_function def: "Interacting selectively and non-covalently with the smoothened (smo) protein, which interacts with patched to transmit hedgehog signals." [GOC:ceb, PMID:11731473] synonym: "smo binding" EXACT [] synonym: "smo ligand" NARROW [] synonym: "smoothened ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005121 name: Toll binding namespace: molecular_function def: "Interacting selectively and non-covalently with the Toll protein, a transmembrane receptor." [GOC:ceb] synonym: "Tl binding" EXACT [] synonym: "Toll ligand" NARROW [] synonym: "Toll receptor binding" EXACT [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005122 name: torso binding namespace: molecular_function def: "Interacting selectively and non-covalently with the torso (tor) protein, a receptor tyrosine kinase." [FB:gn0003733, GOC:ceb] synonym: "tor binding" EXACT [] synonym: "tor ligand" NARROW [] synonym: "torso ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005123 name: death receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any member of the death receptor (DR) family. The DR family falls within the tumor necrosis factor receptor superfamily and is characterized by a cytoplasmic region of ~80 residues termed the death domain (DD)." [GOC:ceb, GOC:rl, PMID:15654015] synonym: "APO binding" NARROW [GOC:rl] synonym: "death receptor adaptor protein activity" RELATED [] synonym: "death receptor interacting protein activity" RELATED [] synonym: "death receptor ligand" NARROW [] synonym: "death receptor-associated factor activity" RELATED [] synonym: "DR binding" NARROW [GOC:rl] synonym: "EDAR binding" NARROW [GOC:rl] synonym: "FAS binding" NARROW [GOC:rl] synonym: "KILLER binding" NARROW [GOC:rl] synonym: "NGFR binding" NARROW [GOC:rl] synonym: "TNFR1 binding" NARROW [GOC:rl] synonym: "TRAIL binding" NARROW [GOC:rl] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005124 name: scavenger receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with scavenger receptors, a family of proteins that are expressed on myeloid cells and are involved in the uptake of effete cellular components and foreign particles." [GOC:ceb] synonym: "scavenger receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005125 name: cytokine activity namespace: molecular_function def: "Functions to control the survival, growth, differentiation and effector function of tissues and cells." [ISBN:0198599471] synonym: "autocrine activity" RELATED [GOC:rl] synonym: "paracrine activity" RELATED [GOC:rl] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005126 name: cytokine receptor binding namespace: molecular_function def: "Interacting selectively with a cytokine receptor." [GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor binding" EXACT [GOC:add, GOC:mah] synonym: "hematopoietin/interferon-class (D200-domain) cytokine receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005127 name: ciliary neurotrophic factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the ciliary neurotrophic factor receptor." [GOC:ai] synonym: "ciliary neurotrophic factor" NARROW [] synonym: "ciliary neurotrophic factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005128 name: erythropoietin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the erythropoietin receptor." [GOC:ai] synonym: "erythropoietin" NARROW [] synonym: "erythropoietin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005129 name: granulocyte macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "GM-CSF receptor ligand" NARROW [] synonym: "GMC-SF receptor ligand" NARROW [] synonym: "granulocyte macrophage colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte macrophage colony-stimulating factor" NARROW [] synonym: "granulocyte macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005130 name: granulocyte colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the granulocyte colony-stimulating factor receptor." [GOC:ai] synonym: "G-CSF receptor ligand" EXACT [] synonym: "GC-SF receptor ligand" EXACT [] synonym: "granulocyte colony stimulating factor receptor binding" EXACT [] synonym: "granulocyte colony-stimulating factor" NARROW [] synonym: "granulocyte colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005131 name: growth hormone receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the growth hormone receptor." [GOC:ai] synonym: "growth hormone" NARROW [] synonym: "growth hormone receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0051427 ! hormone receptor binding [Term] id: GO:0005132 name: interferon-alpha/beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-alpha/beta receptor." [GOC:ai] synonym: "interferon-alpha/beta" NARROW [] synonym: "interferon-alpha/beta receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005133 name: interferon-gamma receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interferon-gamma receptor." [GOC:ai] synonym: "interferon-gamma" NARROW [] synonym: "interferon-gamma receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005134 name: interleukin-2 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-2 receptor." [GOC:ai] synonym: "IL-2" NARROW [] synonym: "interleukin-2 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005135 name: interleukin-3 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-3 receptor." [GOC:ai] synonym: "IL-3" NARROW [] synonym: "interleukin-3 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005136 name: interleukin-4 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-4 receptor." [GOC:ai] synonym: "IL-4" NARROW [] synonym: "interleukin-4 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005137 name: interleukin-5 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-5 receptor." [GOC:ai] synonym: "IL-5" NARROW [] synonym: "interleukin-5 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005138 name: interleukin-6 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-6 receptor." [GOC:ai] synonym: "IL-6" NARROW [] synonym: "interleukin-6 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005139 name: interleukin-7 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-7 receptor." [GOC:ai] synonym: "IL-7" NARROW [] synonym: "interleukin-7 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005140 name: interleukin-9 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-9 receptor." [GOC:ai] synonym: "IL-9" NARROW [] synonym: "interleukin-9 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005141 name: interleukin-10 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-10 receptor." [GOC:ai] synonym: "IL-10" NARROW [] synonym: "interleukin-10 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005142 name: interleukin-11 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-11 receptor." [GOC:ai] synonym: "IL-11" NARROW [] synonym: "interleukin-11 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005143 name: interleukin-12 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-12 receptor." [GOC:ai] synonym: "IL-12" NARROW [] synonym: "interleukin-12 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005144 name: interleukin-13 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-13 receptor." [GOC:ai] synonym: "IL-13" NARROW [] synonym: "interleukin-13 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005145 name: interleukin-14 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-14 receptor." [GOC:ai] synonym: "IL-14" NARROW [] synonym: "interleukin-14 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005146 name: leukemia inhibitory factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the leukemia inhibitory factor receptor." [GOC:ai] synonym: "leukemia inhibitory factor" NARROW [] synonym: "leukemia inhibitory factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005147 name: oncostatin-M receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the oncostatin-M receptor." [GOC:ai] synonym: "oncostatin-M" NARROW [] synonym: "oncostatin-M receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005148 name: prolactin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the prolactin receptor." [GOC:ai] synonym: "prolactin" NARROW [] synonym: "prolactin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005149 name: interleukin-1 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-1 receptor." [GOC:go_curators] synonym: "IL-1" NARROW [] synonym: "interleukin-1 receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005150 name: interleukin-1, Type I receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type I interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type I" NARROW [] synonym: "interleukin-1, Type I receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005151 name: interleukin-1, Type II receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a Type II interleukin-1 receptor." [GOC:ai] synonym: "IL-1 type II" NARROW [] synonym: "interleukin-1, Type II receptor ligand" NARROW [] is_a: GO:0005149 ! interleukin-1 receptor binding [Term] id: GO:0005152 name: interleukin-1 receptor antagonist activity namespace: molecular_function def: "Blocks the binding of interleukin-1 to the interleukin-1 receptor complex." [GOC:ebc] synonym: "IL-1ra" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0030353 ! fibroblast growth factor receptor antagonist activity [Term] id: GO:0005153 name: interleukin-8 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the interleukin-8 receptor." [GOC:go_curators] synonym: "IL-8" NARROW [] synonym: "interleukin-8 receptor ligand" NARROW [] is_a: GO:0045236 ! CXCR chemokine receptor binding [Term] id: GO:0005154 name: epidermal growth factor receptor binding namespace: molecular_function alt_id: GO:0008185 def: "Interacting selectively and non-covalently with the epidermal growth factor receptor." [GOC:ai] synonym: "EGF" NARROW [] synonym: "EGF receptor binding" EXACT [] synonym: "EGF receptor ligand" NARROW [] synonym: "EGFR binding" EXACT [] synonym: "epidermal growth factor" NARROW [] synonym: "epidermal growth factor receptor ligand" NARROW [] synonym: "TGF-alpha receptor binding" EXACT [] synonym: "TGFalpha receptor binding" EXACT [] synonym: "transforming growth factor alpha" NARROW [] synonym: "transforming growth factor alpha receptor binding" EXACT [] synonym: "transforming growth factor alpha receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005155 name: epidermal growth factor receptor activating ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor activating ligand activity" EXACT [] synonym: "EGFR activating ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0030297 consider: GO:0045741 [Term] id: GO:0005156 name: epidermal growth factor receptor inhibiting ligand activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:dph, GOC:mah, GOC:tb] comment: This term was made obsolete because it represents both a biological process and a molecular function. synonym: "EGF receptor inhibiting ligand activity" EXACT [] synonym: "EGFR inhibiting ligand activity" EXACT [] is_obsolete: true replaced_by: GO:0005154 consider: GO:0007175 consider: GO:0030293 [Term] id: GO:0005157 name: macrophage colony-stimulating factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the macrophage colony-stimulating factor receptor." [GOC:ai] synonym: "macrophage colony stimulating factor receptor binding" EXACT [] synonym: "macrophage colony-stimulating factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005158 name: insulin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the insulin receptor." [GOC:ai] synonym: "insulin receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding is_a: GO:0032403 ! protein complex binding [Term] id: GO:0005159 name: insulin-like growth factor receptor binding namespace: molecular_function alt_id: GO:0005067 def: "Interacting selectively and non-covalently with the insulin-like growth factor receptor." [GOC:jl] synonym: "IGF receptor binding" EXACT [] synonym: "insulin-like growth factor" NARROW [] synonym: "insulin-like growth factor receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005160 name: transforming growth factor beta receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the transforming growth factor beta receptor." [GOC:ai] synonym: "activin" RELATED [] synonym: "inhibin" RELATED [] synonym: "TGF-beta receptor binding" EXACT [] synonym: "TGFbeta receptor binding" EXACT [] synonym: "transforming growth factor beta" NARROW [] synonym: "transforming growth factor beta ligand binding to type I receptor" RELATED [] synonym: "transforming growth factor beta ligand binding to type II receptor" RELATED [] synonym: "transforming growth factor beta receptor anchoring activity" RELATED [] synonym: "transforming growth factor beta receptor ligand" NARROW [] xref: Reactome:4078 "transforming growth factor beta receptor binding" is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005161 name: platelet-derived growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the platelet-derived growth factor receptor." [GOC:ai] synonym: "PDGF" NARROW [] synonym: "PDGF receptor binding" EXACT [] synonym: "PDGFR binding" EXACT [] synonym: "platelet-derived growth factor" NARROW [] synonym: "platelet-derived growth factor receptor ligand" NARROW [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005163 name: nerve growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the nerve growth factor receptor." [GOC:ai, PMID:15654015] synonym: "nerve growth factor receptor ligand" NARROW [] synonym: "neurotrophin" NARROW [] synonym: "NGF receptor binding" EXACT [] is_a: GO:0005123 ! death receptor binding is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005164 name: tumor necrosis factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the tumor necrosis factor receptor." [GOC:ai] synonym: "TNF receptor binding" EXACT [] synonym: "tumor necrosis factor" NARROW [] synonym: "tumor necrosis factor receptor ligand" NARROW [] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005165 name: neurotrophin receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin receptor." [GOC:ai] synonym: "neurotrophin" NARROW [] synonym: "neurotrophin receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005166 name: neurotrophin p75 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin p75 receptor." [GOC:ai] synonym: "neurotrophin p75 receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005167 name: neurotrophin TRK receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a neurotrophin TRK receptor." [GOC:ai] synonym: "neurotrophin TRK receptor ligand" NARROW [] is_a: GO:0005165 ! neurotrophin receptor binding [Term] id: GO:0005168 name: neurotrophin TRKA receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKA receptor." [GOC:ai] synonym: "neurotrophin TRKA receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005169 name: neurotrophin TRKB receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKB receptor." [GOC:ai] synonym: "neurotrophin TRKB receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005170 name: neurotrophin TRKC receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the neurotrophin TRKC receptor." [GOC:ai] synonym: "neurotrophin TRKC receptor ligand" NARROW [] is_a: GO:0005167 ! neurotrophin TRK receptor binding [Term] id: GO:0005171 name: hepatocyte growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the hepatocyte growth factor receptor." [GOC:ai] synonym: "hepatocyte growth factor" NARROW [] synonym: "hepatocyte growth factor receptor ligand" NARROW [] synonym: "HGF receptor binding" EXACT [] is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005172 name: vascular endothelial growth factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with any vascular endothelial growth factor receptor." [GOC:ai] synonym: "vascular endothelial growth factor" NARROW [] synonym: "vascular endothelial growth factor receptor ligand" NARROW [] synonym: "VEGF receptor binding" EXACT [] synonym: "VEGFR binding" EXACT [] is_a: GO:0005126 ! cytokine receptor binding is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0005173 name: stem cell factor receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the stem cell factor receptor (SCFR), a type III transmembrane kinase receptor." [GOC:jl, PMID:10698217] synonym: "KIT binding" NARROW [] synonym: "SCF" NARROW [] synonym: "SCFR binding" EXACT [] synonym: "stem cell factor" NARROW [] synonym: "stem cell factor receptor ligand" NARROW [] is_a: GO:0005126 ! cytokine receptor binding [Term] id: GO:0005174 name: CD40 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with CD40, a receptor found on the surface of all B-lymphocytes." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005175 name: CD27 receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a CD27, a receptor found on the surface of T cells and some B cells and NK cells." [GOC:jl, ISBN:0120781859] is_a: GO:0032813 ! tumor necrosis factor receptor superfamily binding [Term] id: GO:0005176 name: ErbB-2 class receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the protein-tyrosine kinase receptor Neu/ErbB-2/HER2." [GOC:jl] synonym: "ErbB-2 class receptor ligand" NARROW [] synonym: "HER2 receptor binding" EXACT [] synonym: "HER2 receptor ligand" NARROW [] synonym: "Neu receptor binding" EXACT [] synonym: "Neu receptor ligand" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005177 name: neuroligin namespace: molecular_function def: "OBSOLETE. A class of ligands for neurexins." [GOC:ai] is_obsolete: true consider: GO:0042043 [Term] id: GO:0005178 name: integrin binding namespace: molecular_function def: "Interacting selectively and non-covalently with an integrin." [GOC:ceb] synonym: "integrin ligand" NARROW [] is_a: GO:0005102 ! receptor binding is_a: GO:0032403 ! protein complex binding [Term] id: GO:0005179 name: hormone activity namespace: molecular_function def: "The action characteristic of a hormone, any substance formed in very small amounts in one specialized organ or group of cells and carried (sometimes in the bloodstream) to another organ or group of cells in the same organism, upon which it has a specific regulatory action. The term was originally applied to agents with a stimulatory physiological action in vertebrate animals (as opposed to a chalone, which has a depressant action). Usage is now extended to regulatory compounds in lower animals and plants, and to synthetic substances having comparable effects; all bind receptors and trigger some biological process." [GOC:dph, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "cAMP generating peptide activity" NARROW [] synonym: "glycopeptide hormone" NARROW [] synonym: "lipopeptide hormone" NARROW [] synonym: "peptide hormone" NARROW [] is_a: GO:0005102 ! receptor binding [Term] id: GO:0005180 name: peptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005181 name: glycopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005182 name: lipopeptide hormone namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a type of hormone rather than a molecular function. is_obsolete: true consider: GO:0005179 [Term] id: GO:0005183 name: gonadotropin hormone-releasing hormone activity namespace: molecular_function def: "The action characteristic of gonadotropin hormone-releasing hormone (GnRH), any of a family of decapeptide amide hormones that are released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, GnRH causes the release of follicle-stimulating hormone and luteinizing hormone by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GnRH activity" EXACT [ISBN:0198506732] synonym: "LH/FSH-RF" EXACT [ISBN:0198506732] synonym: "LHRH activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing factor activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone-releasing hormone activity" EXACT [ISBN:0198506732] synonym: "luteinizing hormone/follicle-stimulating hormone releasing factor activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0005184 name: neuropeptide hormone activity namespace: molecular_function def: "The action characteristic of a neuropeptide hormone, any peptide hormone that acts in the central nervous system. A neuropeptide is any of several types of molecules found in brain tissue, composed of short chains of amino acids; they include endorphins, enkephalins, vasopressin, and others. They are often localized in axon terminals at synapses and are classified as putative neurotransmitters, although some are also hormones." [GOC:mah] synonym: "neurohormone" EXACT [] xref: Wikipedia:Neurohormone is_a: GO:0005179 ! hormone activity [Term] id: GO:0005185 name: neurohypophyseal hormone activity namespace: molecular_function is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0005186 name: pheromone activity namespace: molecular_function def: "The activity of binding to and activating specific cell surface receptors, thereby inducing behavioral, developmental, or physiological response(s) from a responding organism or cell. The substance may be released or retained on the cell surface. Pheromones may serve as a specific attractant, social communicator, or sexual stimulant." [GOC:sgd_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005102 ! receptor binding [Term] id: GO:0005187 name: storage protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0005188 name: larval serum protein (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. synonym: "arylphorin" NARROW [] is_obsolete: true [Term] id: GO:0005189 name: milk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005190 name: seminal fluid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005191 name: acidic epididymal glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005192 name: urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005193 name: major urinary protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005194 name: cell adhesion molecule activity namespace: molecular_function def: "OBSOLETE. Mediates the adhesion of the cell to other cells or to the extracellular matrix." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents gene products involved in the biological process of cell adhesion. is_obsolete: true consider: GO:0005102 consider: GO:0005515 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0005198 name: structural molecule activity namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0003674 ! molecular_function [Term] id: GO:0005199 name: structural constituent of cell wall namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cell wall." [GOC:mah] subset: gosubset_prok is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005200 name: structural constituent of cytoskeleton namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a cytoskeletal structure." [GOC:mah] subset: gosubset_prok is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005201 name: extracellular matrix structural constituent namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the extracellular matrix." [GOC:mah] subset: gosubset_prok synonym: "extracellular matrix glycoprotein" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005202 name: collagen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005581 [Term] id: GO:0005203 name: proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. is_obsolete: true [Term] id: GO:0005204 name: chondroitin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005205 name: chondroitin sulfate/dermatan sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) of a gene product, not a molecular function. synonym: "chondroitin sulphate/dermatan sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005206 name: heparin sulfate proteoglycan namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "heparin sulphate proteoglycan" EXACT [] is_obsolete: true [Term] id: GO:0005207 name: extracellular matrix glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes localization and modification rather than activity. is_obsolete: true consider: GO:0005201 [Term] id: GO:0005208 name: amyloid protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005209 name: plasma protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005211 name: plasma glycoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes modification and presence in body fluids rather than an activity. is_obsolete: true [Term] id: GO:0005212 name: structural constituent of eye lens namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the lens of an eye." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005213 name: structural constituent of chorion namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chorion. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] synonym: "structural protein of chorion" NARROW [] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0005214 name: structural constituent of chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a chitin-based cuticle. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] is_a: GO:0042302 ! structural constituent of cuticle [Term] id: GO:0005215 name: transporter activity namespace: molecular_function alt_id: GO:0005478 def: "Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells." [GOC:ai, GOC:df] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "small-molecule carrier or transporter" RELATED [] xref: Reactome:1391 "transporter activity" is_a: GO:0003674 ! molecular_function relationship: part_of GO:0006810 ! transport [Term] id: GO:0005216 name: ion channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of an ion (by an energy-independent process) by passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:cy, GOC:mtg_transport, ISBN:0815340729] subset: goslim_generic subset: gosubset_prok is_a: GO:0015075 ! ion transmembrane transporter activity is_a: GO:0022838 ! substrate-specific channel activity [Term] id: GO:0005217 name: intracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005218 name: intracellular ligand-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a specific intracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005219 name: ryanodine-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when a ryanodine class ligand has been bound by the channel complex or one of its constituent parts." [GOC:dph, GOC:tb] synonym: "caffeine-sensitive calcium-release channel" RELATED [] synonym: "ryanodine receptor" NARROW [] is_a: GO:0005218 ! intracellular ligand-gated calcium channel activity [Term] id: GO:0005220 name: inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a channel that opens when inositol 1,4,5-trisphosphate has been bound by the channel complex or one of its constituent parts." [GOC:mah, PMID:8660280] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0008095 ! inositol-1,4,5-trisphosphate receptor activity is_a: GO:0015278 ! calcium-release channel activity [Term] id: GO:0005221 name: intracellular cyclic nucleotide activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cyclic nucleotide has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity is_a: GO:0043855 ! cyclic nucleotide-gated ion channel activity [Term] id: GO:0005222 name: intracellular cAMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cAMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] synonym: "intracellular 3',5' cAMP activated cation channel activity" EXACT [] synonym: "intracellular 3',5'-cAMP activated cation channel activity" EXACT [] synonym: "intracellular adenosine 3',5'-cyclophosphate activated cation channel activity" EXACT [] synonym: "intracellular cyclic AMP activated cation channel activity" EXACT [] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005223 name: intracellular cGMP activated cation channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a cation by a channel that opens when intracellular cGMP has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport] is_a: GO:0005221 ! intracellular cyclic nucleotide activated cation channel activity [Term] id: GO:0005224 name: ATP-binding and phosphorylation-dependent chloride channel activity namespace: molecular_function is_a: GO:0005217 ! intracellular ligand-gated ion channel activity is_a: GO:0005254 ! chloride channel activity [Term] id: GO:0005225 name: volume-sensitive anion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an anion by a volume-sensitive channel. An anion is a negatively charged ion. A volume-sensitive channel is a channel that responds to changes in the volume of a cell." [GOC:dph, GOC:tb] synonym: "volume-regulated channel" BROAD [] is_a: GO:0005253 ! anion channel activity relationship: part_of GO:0044070 ! regulation of anion transport [Term] id: GO:0005227 name: calcium activated cation channel activity namespace: molecular_function def: "Catalysis of the calcium concentration-regulatable energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport] synonym: "intracellular calcium-activated potassium channel" NARROW [] synonym: "polycystin" NARROW [] is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005228 name: intracellular sodium activated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of potassium by a channel that opens in response to stimulus by a sodium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism. Sodium activated potassium channels have distinctive properties, including a large single channel conductance, subconductance states, and a block of single channel currents at positive potentials, similar to inward rectification." [GOC:mtg_transport, PMID:12628167] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005229 name: intracellular calcium activated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of chloride by a channel that opens in response to stimulus by a calcium ion or ions. Transport by a channel involves catalysis of facilitated diffusion of a solute (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel, without evidence for a carrier-mediated mechanism." [GOC:mtg_transport] is_a: GO:0005254 ! chloride channel activity is_a: GO:0022839 ! ion gated channel activity [Term] id: GO:0005230 name: extracellular ligand-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when a specific extracellular ligand has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005231 name: excitatory extracellular ligand-gated ion channel activity namespace: molecular_function subset: gosubset_prok xref: Reactome:4230 "excitatory extracellular ligand-gated ion channel activity" is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005232 name: serotonin-activated cation-selective channel activity namespace: molecular_function comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'serotonin receptor activity ; GO:0004993'. synonym: "5-hydroxytryptamine-gated receptor-channel" EXACT [] is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity is_a: GO:0005261 ! cation channel activity [Term] id: GO:0005234 name: extracellular-glutamate-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. subset: gosubset_prok is_a: GO:0005231 ! excitatory extracellular ligand-gated ion channel activity [Term] id: GO:0005237 name: inhibitory extracellular ligand-gated ion channel activity namespace: molecular_function is_a: GO:0005230 ! extracellular ligand-gated ion channel activity [Term] id: GO:0005240 name: glycine receptor-associated protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a molecular function. is_obsolete: true consider: GO:0005515 [Term] id: GO:0005241 name: inward rectifier channel namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true consider: GO:0005242 [Term] id: GO:0005242 name: inward rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an inwardly-rectifying voltage-gated channel. An inwardly rectifying current-voltage relation is one where at any given driving force the inward flow of K+ ions exceeds the outward flow for the opposite driving force. The inward-rectification is due to a voltage-dependent block of the channel pore by a specific ligand or ligands, and as a result the macroscopic conductance depends on the difference between membrane voltage and the K+ equilibrium potential rather than on membrane voltage itself." [GOC:cb, GOC:mah, PMID:14977398] subset: gosubset_prok synonym: "Kir channel activity" EXACT [GOC:cb] is_a: GO:0005249 ! voltage-gated potassium channel activity is_a: GO:0015276 ! ligand-gated ion channel activity [Term] id: GO:0005243 name: gap junction channel activity namespace: molecular_function alt_id: GO:0015285 alt_id: GO:0015286 def: "A wide pore channel activity that enables a direct cytoplasmic connection from one cell to an adjacent cell. The gap junction can pass large solutes as well as electrical signals between cells. Gap junctions consist of two gap junction hemi-channels, or connexons, one contributed by each membrane through which the gap junction passes." [GOC:dgh, GOC:mtg_transport, ISBN:0815340729] synonym: "connexin" RELATED [] synonym: "innexin" NARROW [] synonym: "innexin channel activity" EXACT [] synonym: "intercellular channel" BROAD [] xref: Reactome:13185 "gap junction channel activity" is_a: GO:0022829 ! wide pore channel activity [Term] id: GO:0005244 name: voltage-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a voltage-gated channel. An ion is an atom or group of atoms carrying an electric charge by virtue of having gained or lost one or more electrons." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated ion channel activity" EXACT [] synonym: "voltage-dependent ion channel activity" EXACT [] is_a: GO:0005216 ! ion channel activity is_a: GO:0022832 ! voltage-gated channel activity relationship: part_of GO:0034765 ! regulation of ion transmembrane transport [Term] id: GO:0005245 name: voltage-gated calcium channel activity namespace: molecular_function alt_id: GO:0010173 def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel." [GOC:mtg_transport, GOC:tb, ISBN:0815340729] synonym: "depolarization-activated calcium channel" BROAD [] synonym: "depolarization-activated voltage gated calcium channel activity" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel" EXACT [] synonym: "depolarization-activated voltage-gated calcium channel activity" EXACT [] synonym: "voltage gated calcium channel activity" EXACT [] synonym: "voltage-dependent calcium channel activity" EXACT [] synonym: "voltage-gated calcium ion channel activity" EXACT [] synonym: "voltage-sensitive calcium channel" EXACT [] xref: Reactome:13187 "voltage-gated calcium channel activity" is_a: GO:0005262 ! calcium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity relationship: part_of GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity [Term] id: GO:0005246 name: calcium channel regulator activity namespace: molecular_function def: "Modulates the activity of a calcium channel." [GOC:mah] is_a: GO:0016247 ! channel regulator activity relationship: regulates GO:0005262 ! calcium channel activity [Term] id: GO:0005247 name: voltage-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated chloride channel activity" EXACT [] synonym: "voltage-dependent chloride channel activity" EXACT [] is_a: GO:0005254 ! chloride channel activity is_a: GO:0008308 ! voltage-gated anion channel activity [Term] id: GO:0005248 name: voltage-gated sodium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a sodium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage gated sodium channel activity" EXACT [] synonym: "voltage-dependent sodium channel activity" EXACT [] synonym: "voltage-gated sodium ion channel activity" EXACT [] synonym: "voltage-sensitive sodium channel" EXACT [] is_a: GO:0005272 ! sodium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005249 name: voltage-gated potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "voltage gated potassium channel activity" EXACT [] synonym: "voltage-dependent potassium channel activity" EXACT [] synonym: "voltage-gated potassium ion channel activity" EXACT [] synonym: "voltage-sensitive potassium channel" EXACT [] is_a: GO:0005267 ! potassium channel activity is_a: GO:0022843 ! voltage-gated cation channel activity [Term] id: GO:0005250 name: A-type (transient outward) potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an outwardly-rectifying voltage-gated channel that produces a transient outward current upon a step change in membrane potential." [GOC:mah, PMID:5575340] is_a: GO:0015271 ! outward rectifier potassium channel activity [Term] id: GO:0005251 name: delayed rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by a delayed rectifying voltage-gated channel. A delayed rectifying current-voltage relation is one where channel activation kinetics are time-dependent, and activation is slow." [GOC:mah, PMID:11343411, PMID:2462513] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005252 name: open rectifier potassium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a potassium ion by an open rectifier voltage-gated channel. An open rectifier current-voltage relationship is one in which the direction of rectification depends on the external potassium ion concentration." [GOC:mah, PMID:8917578] is_a: GO:0005249 ! voltage-gated potassium channel activity [Term] id: GO:0005253 name: anion channel activity namespace: molecular_function def: "Catalysis of the energy-independent passage of anions across a lipid bilayer down a concentration gradient." [GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0005216 ! ion channel activity is_a: GO:0008509 ! anion transmembrane transporter activity [Term] id: GO:0005254 name: chloride channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a chloride (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok xref: Reactome:4244 "chloride channel activity" is_a: GO:0005253 ! anion channel activity relationship: part_of GO:0006821 ! chloride transport [Term] id: GO:0005260 name: channel-conductance-controlling ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate. An animal enzyme that is active in forming a chloride channel, the absence of which brings about cystic fibrosis. It is also involved in the functioning of other transmembrane channels." [EC:3.6.3.49] synonym: "ATP phosphohydrolase (channel-conductance-controlling)" EXACT [EC:3.6.3.49] synonym: "cystic fibrosis transmembrane conductance regulator" NARROW [] synonym: "cystic-fibrosis membrane-conductance-regulating protein activity" NARROW [EC:3.6.3.49] xref: EC:3.6.3.49 xref: MetaCyc:3.6.3.49-RXN is_a: GO:0005254 ! chloride channel activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0005261 name: cation channel activity namespace: molecular_function alt_id: GO:0015281 alt_id: GO:0015338 def: "Catalysis of the energy-independent passage of cations across a lipid bilayer down a concentration gradient." [GOC:def, GOC:dph, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "cation diffusion facilitator activity" EXACT [] synonym: "nonselective cation channel activity" EXACT [] xref: Reactome:13089 "cation channel activity" is_a: GO:0005216 ! ion channel activity is_a: GO:0008324 ! cation transmembrane transporter activity [Term] id: GO:0005262 name: calcium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a calcium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] xref: Reactome:13088 "calcium channel activity" is_a: GO:0005261 ! cation channel activity relationship: part_of GO:0070588 ! calcium ion transmembrane transport [Term] id: GO:0005267 name: potassium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a potassium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok is_a: GO:0005261 ! cation channel activity relationship: part_of GO:0006813 ! potassium ion transport [Term] id: GO:0005272 name: sodium channel activity namespace: molecular_function def: "Catalysis of facilitated diffusion of a sodium ion (by an energy-independent process) involving passage through a transmembrane aqueous pore or channel without evidence for a carrier-mediated mechanism." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005261 ! cation channel activity relationship: part_of GO:0006814 ! sodium ion transport [Term] id: GO:0005274 name: allantoin uptake transmembrane transporter activity namespace: molecular_function alt_id: GO:0015206 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: allantoin(out) + H+(out) = allantoin(in) + H+(in) by secondary active transport." [GOC:mtg_transport, ISBN:0815340729, TC:2.A.39.3.1] synonym: "allantoin permease activity" RELATED [] synonym: "allantoin/allantoate transporter" BROAD [] is_a: GO:0015391 ! nucleobase:cation symporter activity is_a: GO:0015563 ! uptake transmembrane transporter activity relationship: part_of GO:0015720 ! allantoin transport [Term] id: GO:0005275 name: amine transmembrane transporter activity namespace: molecular_function alt_id: GO:0005279 def: "Catalysis of the transfer of amines, including polyamines, from one side of the membrane to the other. Amines are organic compounds that are weakly basic in character and contain an amino (-NH2) or substituted amino group." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "amine/amide/polyamine channel activity" BROAD [] synonym: "amine/polyamine transmembrane transporter activity" EXACT [] synonym: "amino acid-polyamine transmembrane transporter activity" EXACT [] is_a: GO:0022804 ! active transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0015837 ! amine transport [Term] id: GO:0005276 name: hydrogen:vesicular amine antiporter activity namespace: molecular_function xref: Reactome:13287 "hydrogen:vesicular amine antiporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0005277 name: acetylcholine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of acetylcholine from one side of the membrane to the other. Acetylcholine is an acetic acid ester of the organic base choline and functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions." [GOC:ai] xref: Reactome:13291 "acetylcholine transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0005326 ! neurotransmitter transporter activity relationship: part_of GO:0015870 ! acetylcholine transport [Term] id: GO:0005278 name: acetylcholine:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: H+(out) + acetylcholine(in) = H+(in) + acetylcholine(out)." [TC:2.A.1.2.13] synonym: "acetylcholine:proton antiporter activity" EXACT [] is_a: GO:0005277 ! acetylcholine transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity [Term] id: GO:0005280 name: hydrogen:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + H+(out) = amino acid(in) + H+(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter" BROAD [] is_a: GO:0005416 ! cation:amino acid symporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0005281 name: general amino acid permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "general amino acid transporter" BROAD [] is_obsolete: true replaced_by: GO:0015171 [Term] id: GO:0005283 name: sodium:amino acid symporter activity namespace: molecular_function alt_id: GO:0005285 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + Na+(out) = amino acid(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "sodium/amino acid transporter activity" BROAD [] synonym: "sodium/excitatory amino acid cotransporter activity" BROAD [] synonym: "sodium/excitatory amino acid symporter activity" EXACT [] synonym: "sodium:amino acid transporter activity" BROAD [] synonym: "threonine/serine:sodium symporter activity" NARROW [] is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005416 ! cation:amino acid symporter activity [Term] id: GO:0005284 name: insulin-activated sodium:amino acid symporter activity namespace: molecular_function synonym: "insulin-activated sodium/amino acid transporter activity" EXACT [] synonym: "insulin-activated sodium:amino acid transporter activity" EXACT [] is_a: GO:0005283 ! sodium:amino acid symporter activity [Term] id: GO:0005287 name: high affinity basic amino acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of basic amino acids from one side of a membrane to the other. Acidic amino acids have a pH above 7. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity basic amino acid transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity [Term] id: GO:0005289 name: high affinity arginine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of arginine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity arginine transporter activity" BROAD [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0015181 ! arginine transmembrane transporter activity [Term] id: GO:0005290 name: L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "histidine/arginine/lysine/ornithine porter activity" NARROW [] synonym: "L-histidine transporter activity" BROAD [] is_a: GO:0015174 ! basic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015817 ! histidine transport [Term] id: GO:0005291 name: high affinity L-histidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-histidine from one side of a membrane to the other. L-histidine is 2-amino-3-(1H-imidazol-4-yl)propanoic acid. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity histidine permease activity" RELATED [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0005290 ! L-histidine transmembrane transporter activity [Term] id: GO:0005292 name: high affinity lysine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of lysine from one side of a membrane to the other. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high affinity lysine transporter activity" BROAD [] is_a: GO:0005287 ! high affinity basic amino acid transmembrane transporter activity is_a: GO:0015189 ! L-lysine transmembrane transporter activity [Term] id: GO:0005294 name: neutral L-amino acid secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a neutral L-amino acid from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "neutral L-amino acid porter activity" RELATED [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005295 name: neutral amino acid:sodium symporter activity namespace: molecular_function alt_id: GO:0005282 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neutral amino acid(out) + Na+(out) = neutral amino acid(in) + Na+(in)." [TC:2.A.23.3.1] synonym: "neutral amino acid-sodium cotransporter" BROAD [] synonym: "sodium/neutral amino acid transporter" BROAD [] is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity [Term] id: GO:0005297 name: hydrogen:proline symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + H+(out) = proline(in) + H+(in)." [GOC:ai] synonym: "hydrogen/proline transporter" BROAD [] is_a: GO:0005280 ! hydrogen:amino acid symporter activity is_a: GO:0015193 ! L-proline transmembrane transporter activity [Term] id: GO:0005298 name: proline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: proline(out) + Na+(out) = proline(in) + Na+(in)." [TC:2.A.22.2.1] subset: gosubset_prok synonym: "sodium/proline symporter activity" EXACT [] xref: Reactome:13406 "proline:sodium symporter activity" is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015193 ! L-proline transmembrane transporter activity [Term] id: GO:0005300 name: high-affinity tryptophan transmembrane transporter activity namespace: molecular_function def: "Catalysis of the high-affinity transfer of L-tryptophan from one side of a membrane to the other. Tryptophan is 2-amino-3-(1H-indol-3-yl)propanoic acid." [GOC:mtg_transport, ISBN:0815340729] synonym: "high-affinity tryptophan transporter activity" BROAD [] is_a: GO:0015196 ! L-tryptophan transmembrane transporter activity [Term] id: GO:0005301 name: valine/tyrosine/tryptophan permease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "hydrogen/valine-tyrosine-tryptophan transporter" EXACT [] is_obsolete: true consider: GO:0005302 consider: GO:0005304 consider: GO:0015196 consider: GO:0022857 [Term] id: GO:0005302 name: L-tyrosine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015508 def: "Catalysis of the transfer of L-tyrosine from one side of a membrane to the other. L-tyrosine is 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "L-tyrosine permease activity" EXACT [] synonym: "L-tyrosine transporter activity" BROAD [] synonym: "valine/tyrosine/tryptophan permease activity" RELATED [] is_a: GO:0015173 ! aromatic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015828 ! tyrosine transport [Term] id: GO:0005304 name: L-valine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-valine from one side of a membrane to the other. L-valine is 2-amino-3-methylbutanoic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] synonym: "isoleucine/valine:sodium symporter activity" NARROW [] synonym: "L-valine transporter activity" BROAD [] synonym: "leucine/isoleucine/valine porter activity" NARROW [] synonym: "leucine/valine/isoleucine permease activity" NARROW [] synonym: "valine/tyrosine/tryptophan permease activity" NARROW [] is_a: GO:0015175 ! neutral amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015829 ! valine transport [Term] id: GO:0005307 name: choline:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: choline(out) + Na+(out) = choline(in) + Na+(in)." [TC:2.A.22.3.5] synonym: "sodium/choline symporter activity" EXACT [] is_a: GO:0015220 ! choline transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005308 name: creatine transporter activity namespace: molecular_function def: "Enables the directed movement of creatine into, out of, within or between cells. Creatine is a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:ai] is_a: GO:0051184 ! cofactor transporter activity relationship: part_of GO:0015881 ! creatine transport [Term] id: GO:0005309 name: creatine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: creatine(out) + Na+(out) = creatine(in) + Na+(in)." [TC:2.A.22.3.4] synonym: "sodium/chloride-dependent creatine transporter" BROAD [] xref: Reactome:14013 "creatine:sodium symporter activity" is_a: GO:0005308 ! creatine transporter activity is_a: GO:0005328 ! neurotransmitter:sodium symporter activity [Term] id: GO:0005310 name: dicarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0005312 alt_id: GO:0015365 def: "Catalysis of the transfer of dicarboxylic acids from one side of the membrane to the other. A dicarboxylic acid is an organic acid with two COOH groups." [GOC:ai] subset: gosubset_prok synonym: "dicarboxylate (succinate/fumarate/malate) antiporter activity" NARROW [] synonym: "dicarboxylate carrier" NARROW [] synonym: "dicarboxylic acid permease activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] xref: Reactome:14021 "dicarboxylic acid transmembrane transporter activity" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0006835 ! dicarboxylic acid transport [Term] id: GO:0005311 name: sodium:dicarboxylate/tricarboxylate symporter activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: (dicarboxylate or tricarboxylate)(out) + Na+(out) = (dicarboxylate or tricarboxylate)(in) + Na+(in)." [TC:2.A.47.1.5] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "sodium:dicarboxylate/tricarboxylate cotransporter activity" BROAD [] is_obsolete: true consider: GO:0005310 consider: GO:0005343 consider: GO:0015142 [Term] id: GO:0005313 name: L-glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of L-glutamate from one side of a membrane to the other. L-glutamate is the anion of 2-aminopentanedioic acid." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "glutamate/aspartate porter activity" NARROW [] synonym: "glutamate/aspartate:sodium symporter activity" NARROW [] synonym: "L-glutamate transporter activity" BROAD [] xref: Reactome:13352 "L-glutamate transmembrane transporter activity" is_a: GO:0015172 ! acidic amino acid transmembrane transporter activity is_a: GO:0015179 ! L-amino acid transmembrane transporter activity relationship: part_of GO:0015813 ! L-glutamate transport [Term] id: GO:0005314 name: high-affinity glutamate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glutamate(out) + H+(out) = glutamate(in) + H+(in)." [TC:2.A.3.10.5] synonym: "high-affinity glutamate transporter activity" BROAD [] xref: Reactome:13351 "high-affinity glutamate transmembrane transporter activity" is_a: GO:0005313 ! L-glutamate transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005315 name: inorganic phosphate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005317 def: "Catalysis of the transfer of a inorganic phosphate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005316 name: high affinity inorganic phosphate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: HPO42-(out) + Na+(out) = HPO42-(in) + Na+(in)." [TC:2.A.20.2.2] synonym: "sodium/phosphate cotransporter activity" BROAD [] is_a: GO:0005436 ! sodium:phosphate symporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005318 name: phosphate:hydrogen symporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] synonym: "phosphate:proton symporter activity" EXACT [] is_obsolete: true consider: GO:0015317 [Term] id: GO:0005319 name: lipid transporter activity namespace: molecular_function def: "Enables the directed movement of lipids into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "apolipoprotein" RELATED [] synonym: "lipophorin" NARROW [] xref: Reactome:7042 "lipid transporter activity" is_a: GO:0022892 ! substrate-specific transporter activity relationship: part_of GO:0006869 ! lipid transport [Term] id: GO:0005320 name: apolipoprotein namespace: molecular_function alt_id: GO:0015907 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005319 [Term] id: GO:0005321 name: high-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "HDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005322 name: low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "LDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005323 name: very-low-density lipoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. synonym: "VLDL" EXACT [] is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0005324 name: long-chain fatty acid transporter activity namespace: molecular_function def: "Enables the directed movement of long-chain fatty acids into, out of, within or between cells. Long-chain fatty acids have a chain length of greater than 12 carbons." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "plasma membrane long-chain fatty acid transporter" NARROW [] xref: Reactome:14049 "long-chain fatty acid transporter activity" is_a: GO:0015245 ! fatty acid transporter activity relationship: part_of GO:0015909 ! long-chain fatty acid transport [Term] id: GO:0005325 name: peroxisomal fatty acyl CoA transporter activity namespace: molecular_function alt_id: GO:0008562 def: "Catalysis of the reaction: ATP + H2O + fatty acyl CoA(cis) = ADP + phosphate + fatty acyl CoA(trans). The transport of fatty acyl CoA into and out of peroxisomes." [EC:3.6.3.47] synonym: "ATP phosphohydrolase (fatty-acyl-CoA-transporting)" EXACT [EC:3.6.3.47] synonym: "fatty-acyl-CoA-transporting ATPase" BROAD [] xref: EC:3.6.3.47 xref: Reactome:14052 "peroxisomal fatty acyl CoA transporter activity" is_a: GO:0005324 ! long-chain fatty acid transporter activity is_a: GO:0015607 ! fatty acyl CoA transporter activity relationship: part_of GO:0015910 ! peroxisomal long-chain fatty acid import [Term] id: GO:0005326 name: neurotransmitter transporter activity namespace: molecular_function def: "Enables the directed movement of a neurotransmitter into, out of, within or between cells. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: gosubset_prok synonym: "neurotransmitter transmembrane transporter activity" EXACT [GOC:mah] xref: Reactome:13292 "neurotransmitter transporter activity" is_a: GO:0022857 ! transmembrane transporter activity relationship: part_of GO:0006836 ! neurotransmitter transport [Term] id: GO:0005328 name: neurotransmitter:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: neurotransmitter(out) + Na+(out) = neurotransmitter(in) + Na+(in)." [TC:2.A.22.-.-] subset: gosubset_prok synonym: "sodium/neurotransmitter symporter activity" EXACT [] is_a: GO:0005326 ! neurotransmitter transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005329 name: dopamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of dopamine from one side of the membrane to the other. Dopamine is a catecholamine neurotransmitter and a metabolic precursor of noradrenaline and adrenaline." [GOC:ai] is_a: GO:0008504 ! monoamine transmembrane transporter activity relationship: part_of GO:0015872 ! dopamine transport [Term] id: GO:0005330 name: dopamine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: dopamine(out) + Na+(out) = dopamine(in) + Na+(in)." [TC:2.A.22.1.3] synonym: "sodium/dopamine symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0005329 ! dopamine transmembrane transporter activity [Term] id: GO:0005332 name: gamma-aminobutyric acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: gamma-aminobutyric acid(out) + Na+(out) = gamma-aminobutyric acid(in) + Na+(in)." [TC:2.A.22.3.2] comment: See also the molecular function term 'neurotransmitter:sodium symporter activity ; GO:0005328'. synonym: "4-aminobutanoate:sodium symporter activity" EXACT [] synonym: "4-aminobutyrate:sodium symporter activity" EXACT [] synonym: "betaine/GABA:sodium symporter activity" EXACT [] synonym: "GABA:sodium symporter activity" EXACT [] synonym: "sodium/chloride-dependent GABA transporter activity" BROAD [] xref: Reactome:14075 "gamma-aminobutyric acid:sodium symporter activity" is_a: GO:0005283 ! sodium:amino acid symporter activity is_a: GO:0015185 ! L-gamma-aminobutyric acid transmembrane transporter activity [Term] id: GO:0005333 name: norepinephrine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of norepinephrine from one side of the membrane to the other. Norepinephrine (3,4-dihydroxyphenyl-2-aminoethanol) is a hormone secreted by the adrenal medulla and a neurotransmitter in the sympathetic peripheral nervous system and in some tracts of the CNS. It is also the biosynthetic precursor of epinephrine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "levarterenol transporter activity" EXACT [] synonym: "noradrenaline transporter activity" EXACT [] xref: Wikipedia:Norepinephrine_transporter is_a: GO:0008504 ! monoamine transmembrane transporter activity relationship: part_of GO:0015874 ! norepinephrine transport [Term] id: GO:0005334 name: norephinephrine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: norepinephrine(out) + Na+(out) = norepinephrine(in) + Na+(in)." [TC:2.A.22.1.2] synonym: "noradrenaline:sodium symporter activity" EXACT [] synonym: "sodium/norepinephrine symporter activity" EXACT [] xref: Reactome:14077 "norephinephrine:sodium symporter activity" is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0005333 ! norepinephrine transmembrane transporter activity [Term] id: GO:0005335 name: serotonin:sodium symporter activity namespace: molecular_function alt_id: GO:0005336 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: serotonin(out) + Na+(out) = serotonin(in) + Na+(in)." [TC:2.A.22.1.1] synonym: "sodium/serotonin symporter activity" EXACT [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity [Term] id: GO:0005337 name: nucleoside transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular nucleoside transmembrane transporter activity" NARROW [] xref: Reactome:14083 "nucleoside transmembrane transporter activity" is_a: GO:0015932 ! nucleobase, nucleoside, nucleotide and nucleic acid transmembrane transporter activity relationship: part_of GO:0015858 ! nucleoside transport [Term] id: GO:0005338 name: nucleotide-sugar transmembrane transporter activity namespace: molecular_function alt_id: GO:0005339 def: "Catalysis of the transfer of a nucleotide-sugar from one side of the membrane to the other. A nucleotide-sugar is any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [GOC:ai, GOC:mtg_transport, ISBN:0815340729, PMID:15034926] is_a: GO:0015144 ! carbohydrate transmembrane transporter activity relationship: part_of GO:0015780 ! nucleotide-sugar transport [Term] id: GO:0005340 name: nucleotide-sulfate transmembrane transporter activity namespace: molecular_function alt_id: GO:0005341 def: "Catalysis of the transfer of nucleotide-sulfate from one side of a membrane to the other." [GOC:mtg_transport] synonym: "nucleotide-sulphate transporter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity [Term] id: GO:0005342 name: organic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic acids, any acidic compound containing carbon in covalent linkage, from one side of the membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0015849 ! organic acid transport [Term] id: GO:0005343 name: organic acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: organic acid(out) + Na+(out) = organic acid(in) + Na+(in)." [TC:2.A.28.1.1] subset: gosubset_prok synonym: "sodium/chloride-dependent organic acid cotransporter activity" RELATED [] synonym: "sodium:dicarboxylate/tricarboxylate symporter activity" NARROW [] is_a: GO:0005342 ! organic acid transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005344 name: oxygen transporter activity namespace: molecular_function alt_id: GO:0015033 def: "Enables the directed movement of oxygen into, out of, within or between cells." [GOC:ai] subset: gosubset_prok synonym: "globin" NARROW [] synonym: "hemerythrin" NARROW [] synonym: "hemocyanin" NARROW [] synonym: "oxygen-carrying" NARROW [] is_a: GO:0022892 ! substrate-specific transporter activity relationship: part_of GO:0015671 ! oxygen transport [Term] id: GO:0005345 name: purine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015205 ! nucleobase transmembrane transporter activity relationship: part_of GO:0006863 ! purine transport [Term] id: GO:0005346 name: purine ribonucleotide transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a purine ribonucleotide, any compound consisting of a purine ribonucleoside (a purine organic base attached to a ribose sugar) esterified with (ortho)phosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0015216 ! purine nucleotide transmembrane transporter activity relationship: part_of GO:0015868 ! purine ribonucleotide transport [Term] id: GO:0005347 name: ATP transmembrane transporter activity namespace: molecular_function alt_id: GO:0005348 def: "Catalysis of the transfer of ATP, adenosine triphosphate, from one side of a membrane to the other." [GOC:ai] is_a: GO:0000295 ! adenine nucleotide transmembrane transporter activity relationship: part_of GO:0015867 ! ATP transport [Term] id: GO:0005350 name: pyrimidine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyrimidines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0015205 ! nucleobase transmembrane transporter activity relationship: part_of GO:0015855 ! pyrimidine transport [Term] id: GO:0005351 name: sugar:hydrogen symporter activity namespace: molecular_function alt_id: GO:0005403 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + H+(out) = sugar(in) + H+(in)." [TC:2.A.1.1.-] subset: gosubset_prok synonym: "cation/sugar symporter activity" BROAD [] synonym: "hydrogen:sugar symporter activity" EXACT [] synonym: "hydrogen:sugar transporter activity" BROAD [] synonym: "proton:sugar symporter activity" EXACT [] synonym: "sugar porter activity" RELATED [] synonym: "sugar transporter" BROAD [] synonym: "sugar:hydrogen ion symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0051119 ! sugar transmembrane transporter activity [Term] id: GO:0005352 name: alpha-glucoside:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: alpha-glucoside(out) + H+(out) = alpha-glucoside(in) + H+(in). Alpha-glucosides include trehalose, maltose, turanose, isomaltose, alpha-methylglucoside, maltotriose, palatinose, trehalose and melezitose." [TC:2.A.1.1.11] synonym: "general alpha-glucoside transporter activity" BROAD [] synonym: "general alpha-glucoside:hydrogen symporter activity" EXACT [] synonym: "general alpha-glucoside:proton symporter activity" EXACT [] is_a: GO:0005402 ! cation:sugar symporter activity is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity [Term] id: GO:0005353 name: fructose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015585 alt_id: GO:0019192 def: "Catalysis of the transfer of fructose from one side of the membrane to the other. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "fructose permease activity" EXACT [] synonym: "fructose porter activity" EXACT [] xref: Reactome:7701 "fructose transmembrane transporter activity" is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015755 ! fructose transport [Term] id: GO:0005354 name: galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of galactose from one side of the membrane to the other. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015757 ! galactose transport [Term] id: GO:0005355 name: glucose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015579 def: "Catalysis of the transfer of the hexose monosaccharide glucose from one side of the membrane to the other." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "galactose/glucose (methylgalactoside) porter activity" NARROW [] synonym: "glucose permease activity" EXACT [] synonym: "lactose/glucose efflux transporter activity" NARROW [] xref: Reactome:14118 "glucose transmembrane transporter activity" is_a: GO:0015149 ! hexose transmembrane transporter activity relationship: part_of GO:0015758 ! glucose transport [Term] id: GO:0005356 name: hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "hydrogen:glucose transporter activity" RELATED [] is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0009679 ! hexose:hydrogen symporter activity [Term] id: GO:0005357 name: constitutive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "constitutive hydrogen/glucose transporter activity" BROAD [] synonym: "constitutive hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005358 name: high-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. This activity is constitutive and therefore always present, regardless of demand. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mtg_transport] synonym: "high-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "high-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005359 name: low-affinity hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "low-affinity hydrogen/glucose transporter activity" BROAD [] synonym: "low-affinity hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005360 name: insulin-responsive hydrogen:glucose symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose + H+ = glucose + H+, in response to a stimulus by insulin. Symporter activity enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy." [GOC:mtg_transport] synonym: "insulin-responsive hydrogen:glucose transporter activity" RELATED [] synonym: "transepithelial hydrogen/glucose transporter activity" RELATED [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005361 name: transepithelial hydrogen:glucose symporter activity namespace: molecular_function synonym: "transepithelial hydrogen/glucose transporter activity" BROAD [] synonym: "transepithelial hydrogen:glucose transporter activity" BROAD [] is_a: GO:0005356 ! hydrogen:glucose symporter activity [Term] id: GO:0005362 name: low-affinity glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.21.3.-] synonym: "low-affinity glucose-sodium cotransporter activity" BROAD [] xref: Reactome:14138 "low-affinity glucose:sodium symporter activity" is_a: GO:0005412 ! glucose:sodium symporter activity [Term] id: GO:0005363 name: maltose transmembrane transporter activity namespace: molecular_function alt_id: GO:0015581 def: "Catalysis of the transfer of maltose from one side of the membrane to the other. Maltose is the disaccharide 4-O-alpha-D-glucopyranosyl-D-glucopyranose, an intermediate in the enzymatic breakdown of glycogen and starch." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "maltose porter activity" EXACT [] is_a: GO:0015151 ! alpha-glucoside transmembrane transporter activity is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015768 ! maltose transport [Term] id: GO:0005364 name: maltose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: maltose(out) + H+(out) = maltose(in) + H+(in)." [TC:2.A.1.1.10] synonym: "hydrogen/maltose transporter activity" BROAD [] synonym: "maltose permease" BROAD [] synonym: "maltose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0005363 ! maltose transmembrane transporter activity [Term] id: GO:0005365 name: myo-inositol transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of myo-inositol from one side of the membrane to the other. Myo-inositol is 1,2,3,4,5/4,6-cyclohexanehexol, a growth factor for animals and microorganisms." [GOC:ai] subset: gosubset_prok synonym: "vitamin Bh transporter activity" EXACT [] is_a: GO:0015166 ! polyol transmembrane transporter activity relationship: part_of GO:0015798 ! myo-inositol transport [Term] id: GO:0005366 name: myo-inositol:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + H+(out) = myo-inositol(in) + H+(in)." [TC:2.A.1.1.8] synonym: "hydrogen/myo-inositol transporter activity" BROAD [] synonym: "myo-inositol:proton symporter activity" EXACT [] xref: Reactome:14152 "myo-inositol:hydrogen symporter activity" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity [Term] id: GO:0005367 name: myo-inositol:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: myo-inositol(out) + Na+(out) = myo-inositol(in) + Na+(in)." [TC:2.A.21.4.-] synonym: "myo-inositol-sodium cotransporter activity" BROAD [] xref: Reactome:14154 "myo-inositol:sodium symporter activity" is_a: GO:0005365 ! myo-inositol transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005368 name: taurine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of taurine from one side of the membrane to the other. Taurine (2-aminoethanesulfonic acid) is a sulphur-containing amino acid derivative which is important in the metabolism of fats." [GOC:ai] subset: gosubset_prok is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0008028 ! monocarboxylic acid transmembrane transporter activity relationship: part_of GO:0015734 ! taurine transport [Term] id: GO:0005369 name: taurine:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: taurine(out) + Na+(out) = taurine(in) + Na+(in)." [TC:2.A.22.3.3] synonym: "sodium/chloride-dependent taurine transporter" BROAD [] is_a: GO:0005328 ! neurotransmitter:sodium symporter activity is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0005368 ! taurine transmembrane transporter activity [Term] id: GO:0005371 name: tricarboxylate secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0005370 def: "Catalysis of the transfer of tricarboxylate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "citrate carrier" EXACT [] synonym: "tricarboxylate carrier activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005372 name: water transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of water (H2O) from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0006833 ! water transport [Term] id: GO:0005373 name: heavy metal ion porter activity namespace: molecular_function def: "OBSOLETE. A transporter of heavy metal ions that utilizes a carrier-mediated process to catalyze uniport, symport or antiport between aqueous phases on either side of a lipid membrane." [GOC:ai] comment: This term was made obsolete because it represents a gene product and not a molecular function. synonym: "metal ion transporter" BROAD [] is_obsolete: true consider: GO:0015291 consider: GO:0046873 [Term] id: GO:0005375 name: copper ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005378 alt_id: GO:0005379 alt_id: GO:0005380 def: "Catalysis of the transfer of copper (Cu) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "intracellular copper ion transporter" NARROW [] synonym: "plasma membrane copper transporter" NARROW [] xref: Reactome:7026 "copper ion transmembrane transporter activity" is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0035434 ! copper ion transmembrane transport [Term] id: GO:0005376 name: plasma membrane copper transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005375 consider: GO:0005886 [Term] id: GO:0005377 name: intracellular copper ion transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. synonym: "intracellular copper transporter" EXACT [] is_obsolete: true replaced_by: GO:0005375 replaced_by: GO:0005622 [Term] id: GO:0005381 name: iron ion transmembrane transporter activity namespace: molecular_function alt_id: GO:0005382 alt_id: GO:0016033 def: "Catalysis of the transfer of iron (Fe) ions from one side of a membrane to the other." [GOC:ai] subset: gosubset_prok synonym: "iron transporter activity" EXACT [] synonym: "multicopper ferroxidase iron transport mediator activity" RELATED [] synonym: "transmembrane iron ion permease activity" EXACT [] synonym: "transmembrane iron permease activity" EXACT [] synonym: "zinc, iron permease activity" RELATED [] xref: Reactome:10390 "iron ion transmembrane transporter activity" is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0005384 name: manganese ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of manganese (Mn) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0071421 ! manganese ion transmembrane transport [Term] id: GO:0005385 name: zinc ion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of zinc (Zn) ions from one side of a membrane to the other." [GOC:df] subset: gosubset_prok synonym: "cobalt, zinc uptake permease activity" NARROW [] synonym: "zinc, cadmium uptake permease activity" NARROW [] synonym: "zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity" NARROW [] synonym: "zinc, iron permease activity" NARROW [] xref: Reactome:14183 "zinc ion transmembrane transporter activity" is_a: GO:0015082 ! di-, tri-valent inorganic cation transmembrane transporter activity is_a: GO:0046915 ! transition metal ion transmembrane transporter activity relationship: part_of GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0005388 name: calcium-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Ca2+(cis) = ADP + phosphate + Ca2+(trans)." [EC:3.6.3.8] subset: gosubset_prok synonym: "ATP phosphohydrolase (Ca2+-transporting)" EXACT [EC:3.6.3.8] synonym: "Ca(2+)-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-pumping ATPase activity" EXACT [EC:3.6.3.8] synonym: "Ca2+-transporting ATPase activity" EXACT [EC:3.6.3.8] synonym: "calcium ABC transporter" NARROW [] synonym: "calcium efflux ATPase" NARROW [] synonym: "calcium pump" BROAD [] synonym: "calcium transporting ATPase activity" EXACT [] synonym: "calcium-translocating P-type ATPase activity" NARROW [EC:3.6.3.8] synonym: "plasma membrane Ca-ATPase" NARROW [EC:3.6.3.8] synonym: "sarco(endo)plasmic reticulum Ca2+-ATPase" NARROW [EC:3.6.3.8] synonym: "sarcoplasmic reticulum ATPase" NARROW [] xref: EC:3.6.3.8 xref: MetaCyc:3.6.3.8-RXN is_a: GO:0015085 ! calcium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism is_a: GO:0019829 ! cation-transporting ATPase activity [Term] id: GO:0005391 name: sodium:potassium-exchanging ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in)." [EC:3.6.3.9] subset: gosubset_prok synonym: "(Na+ + K+)-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "(Na+ + K+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "ATP phosphohydrolase (Na+/K+-exchanging)" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+,K+ pump" RELATED [EC:3.6.3.9] synonym: "Na+,K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "na+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-activated ATPase activity" EXACT [EC:3.6.3.9] synonym: "Na,K-pump" RELATED [EC:3.6.3.9] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase activity" EXACT [] synonym: "sodium/potassium-transporting ATPase activity" EXACT [EC:3.6.3.9] synonym: "sodium:potassium exchanging ATPase activity" EXACT [] xref: EC:3.6.3.9 xref: MetaCyc:3.6.3.9-RXN is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0005395 name: eye pigment precursor transporter activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O + eye pigment precursor(in) = ADP + phosphate + eye pigment precursor(out)." [TC:3.A.1.204.1] is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0005396 name: transmembrane conductance regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because its meaning was ambiguous, it was undefined and its position in the tree wrong. is_obsolete: true consider: GO:0043267 [Term] id: GO:0005400 name: peroxisomal membrane transporter namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0005215 consider: GO:0005777 [Term] id: GO:0005402 name: cation:sugar symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sugar(out) + cation(out) = sugar(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/sugar symporter activity" EXACT [] synonym: "sugar:cation symporter activity" EXACT [] is_a: GO:0015294 ! solute:cation symporter activity relationship: part_of GO:0034219 ! carbohydrate transmembrane transport [Term] id: GO:0005412 name: glucose:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose(out) + Na+(out) = glucose(in) + Na+(in)." [TC:2.A.21.3.-] synonym: "sodium/glucose symporter activity" EXACT [] xref: Reactome:14139 "glucose:sodium symporter activity" is_a: GO:0005355 ! glucose transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005415 name: nucleoside:sodium symporter activity namespace: molecular_function alt_id: GO:0008522 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nucleoside(out) + Na+(out) = nucleoside(in) + Na+(in)." [GOC:ai] subset: gosubset_prok synonym: "nucleoside-sodium cotransporter activity" BROAD [] synonym: "sodium-dependent nucleoside transporter activity" BROAD [] xref: Reactome:14944 "nucleoside:sodium symporter activity" is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0005416 name: cation:amino acid symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: amino acid(out) + cation(out) = amino acid(in) + cation(in)." [GOC:ai] subset: gosubset_prok synonym: "cation/amino acid symporter activity" EXACT [] is_a: GO:0015171 ! amino acid transmembrane transporter activity is_a: GO:0015294 ! solute:cation symporter activity [Term] id: GO:0005427 name: proton-dependent oligopeptide secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a oligopeptide from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by proton movement." [GOC:mtg_transport, OMIM:600544] subset: gosubset_prok synonym: "hydrogen/oligopeptide symporter" RELATED [] synonym: "proton-dependent oligopeptide transporter activity" EXACT [] is_a: GO:0015322 ! secondary active oligopeptide transmembrane transporter activity [Term] id: GO:0005429 name: chromaffin granule amine transmembrane transporter activity namespace: molecular_function is_a: GO:0005275 ! amine transmembrane transporter activity relationship: part_of GO:0015841 ! chromaffin granule amine transport [Term] id: GO:0005430 name: synaptic vesicle amine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amines across synaptic vesicle membranes." [GOC:ai] is_a: GO:0005275 ! amine transmembrane transporter activity relationship: part_of GO:0015842 ! synaptic vesicle amine transport [Term] id: GO:0005432 name: calcium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in)." [GOC:curators, PMID:16371597] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" RELATED [] synonym: "sodium/calcium exchanger" EXACT [] synonym: "sodium:calcium exchange" RELATED [] xref: Reactome:14991 "calcium:sodium antiporter activity" is_a: GO:0015368 ! calcium:cation antiporter activity [Term] id: GO:0005436 name: sodium:phosphate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + phosphate(out) = Na+(in) + phosphate(in)." [GOC:ai] subset: gosubset_prok synonym: "sodium/phosphate symporter activity" EXACT [] is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015114 ! phosphate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0005451 name: monovalent cation:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: monovalent cation(out) + H+(in) = monovalent cation(in) + H+(out)." [GOC:ai] subset: gosubset_prok synonym: "monovalent cation:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015299 ! solute:hydrogen antiporter activity is_a: GO:0015491 ! cation:cation antiporter activity [Term] id: GO:0005452 name: inorganic anion exchanger activity namespace: molecular_function xref: Reactome:15027 "inorganic anion exchanger activity" is_a: GO:0015380 ! anion exchanger activity [Term] id: GO:0005456 name: CMP-sialic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a CMP-sialic acid from one side of the membrane to the other. CMP-sialic acid is a substance composed of sialic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015782 ! CMP-sialic acid transport [Term] id: GO:0005457 name: GDP-fucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-fucose from one side of the membrane to the other. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015783 ! GDP-fucose transport [Term] id: GO:0005458 name: GDP-mannose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a GDP-mannose from one side of the membrane to the other. GDP-mannose is a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015784 ! GDP-mannose transport [Term] id: GO:0005459 name: UDP-galactose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-galactose from one side of the membrane to the other. UDP-galactose is a substance composed of galactose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015785 ! UDP-galactose transport [Term] id: GO:0005460 name: UDP-glucose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucose from one side of the membrane to the other. UDP-glucose is a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015786 ! UDP-glucose transport [Term] id: GO:0005461 name: UDP-glucuronic acid transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-glucuronic acid from one side of the membrane to the other. UDP-glucuronic acid is a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] xref: Reactome:15054 "UDP-glucuronic acid transmembrane transporter activity" is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015787 ! UDP-glucuronic acid transport [Term] id: GO:0005462 name: UDP-N-acetylglucosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a UDP-N-acetylglucosamine from one side of the membrane to the other. N-acetylglucosamine is a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015788 ! UDP-N-acetylglucosamine transport [Term] id: GO:0005463 name: UDP-N-acetylgalactosamine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a N-acetylgalactosamine from one side of the membrane to the other. N-acetylgalactosamine is a substance composed of N-acetylgalactosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai, GOC:mtg_transport, ISBN:0815340729] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015789 ! UDP-N-acetylgalactosamine transport [Term] id: GO:0005464 name: UDP-xylose transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of UDP-xylose from one side of the membrane to the other. UDP-xylose is a substance composed of xylose in glycosidic linkage with uridine diphosphate." [GOC:ai] is_a: GO:0015165 ! pyrimidine nucleotide sugar transmembrane transporter activity relationship: part_of GO:0015790 ! UDP-xylose transport [Term] id: GO:0005468 name: small-molecule carrier or transporter namespace: molecular_function alt_id: GO:0005453 alt_id: GO:0005454 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not provide a useful functional classification. is_obsolete: true consider: GO:0005215 [Term] id: GO:0005469 name: succinate:fumarate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + fumarate(in) = succinate(in) + fumarate(out)." [TC:2.A.29.13.1] is_a: GO:0015138 ! fumarate transmembrane transporter activity is_a: GO:0015141 ! succinate transmembrane transporter activity is_a: GO:0015297 ! antiporter activity [Term] id: GO:0005471 name: ATP:ADP antiporter activity namespace: molecular_function alt_id: GO:0005349 def: "Catalysis of the reaction: ATP(out) + ADP(in) = ATP(in) + ADP(out)." [TC:2.A.29.1.1] subset: gosubset_prok synonym: "adenine nucleotide translocase" EXACT [] synonym: "ADP/ATP translocase" EXACT [] synonym: "ATP/ADP exchange" EXACT [] synonym: "ATP/ADP exchanger" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0005472 name: FAD carrier activity namespace: molecular_function synonym: "flavin adenine dinucleotide carrier activity" EXACT [] synonym: "flavin-adenine dinucleotide carrier activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0005476 name: carnitine:acyl carnitine antiporter activity namespace: molecular_function def: "Catalysis of the reaction: carnitine (mitochondrial) + acyl carnitine (cytoplasm) = carnitine (cytoplasm) + acyl carnitine (mitochondrial)." [PMID:9032458] synonym: "carnitine/acyl carnitine carrier activity" EXACT [] synonym: "carnitine:acyl carnitine carrier activity" EXACT [] synonym: "fatty acyl carnitine carrier" EXACT [] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0005477 name: pyruvate secondary active transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of pyruvate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "pyruvate carrier activity" RELATED [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0050833 ! pyruvate transmembrane transporter activity [Term] id: GO:0005479 name: vacuolar assembly namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0007033 [Term] id: GO:0005480 name: vesicle transport namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0016192 [Term] id: GO:0005481 name: vesicle fusion namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true consider: GO:0006906 consider: GO:0007086 consider: GO:0016189 consider: GO:0016192 consider: GO:0019817 [Term] id: GO:0005482 name: vesicle targeting namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true consider: GO:0006903 consider: GO:0016080 [Term] id: GO:0005483 name: soluble NSF attachment protein activity namespace: molecular_function def: "Interacting selectively and non-covalently with both N-ethylmaleimide-sensitive fusion protein (NSF) and a cis-SNARE complex (i.e. a SNARE complex in which all proteins are associated with the same membrane) and increasing the ATPase activity of NSF, thereby allowing ATP hydrolysis by NSF to disassemble the cis-SNARE complex." [GOC:mah, PMID:14570579, PMID:15556857] synonym: "SNAP" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005484 name: SNAP receptor activity namespace: molecular_function alt_id: GO:0005485 alt_id: GO:0005486 def: "Acting as a marker to identify a membrane and interacting selectively with one or more SNAREs on another membrane to mediate membrane fusion." [GOC:mah, PMID:14570579] synonym: "Q-SNARE activity" NARROW [] synonym: "R-SNARE activity" NARROW [] synonym: "SNAP-25" NARROW [] synonym: "SNARE" EXACT [] synonym: "t-SNARE activity" NARROW [] synonym: "v-SNARE activity" NARROW [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005487 name: nucleocytoplasmic transporter activity namespace: molecular_function def: "Enables the directed movement of substances between the nucleus and the cytoplasm of a cell." [GOC:ai] xref: Reactome:15116 "nucleocytoplasmic transporter activity" is_a: GO:0005215 ! transporter activity relationship: part_of GO:0006913 ! nucleocytoplasmic transport [Term] id: GO:0005488 name: binding namespace: molecular_function def: "The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule." [GOC:ceb, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: For ligands that bind to signal transducing receptors, consider the molecular function term 'receptor binding ; GO:0005102' and its children. subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "ligand" NARROW [] xref: Wikipedia:Binding_(molecular) is_a: GO:0003674 ! molecular_function [Term] id: GO:0005489 name: electron transporter activity namespace: molecular_function def: "OBSOLETE. Enables the directed movement of electrons into, out of, within or between cells." [GOC:ai] comment: This term was made obsolete because the activity described by the definition does not exist. synonym: "class I cytochrome c" RELATED [] synonym: "class II cytochrome c" RELATED [] synonym: "class IIa cytochrome c" RELATED [] synonym: "class IIb cytochrome c" RELATED [] synonym: "class III cytochrome c" RELATED [] synonym: "class IV cytochrome c" RELATED [] synonym: "cytochrome b" RELATED [] synonym: "cytochrome b5" RELATED [] synonym: "cytochrome c3 (tetraheme)" RELATED [] synonym: "cytochrome c554" RELATED [] synonym: "cytochrome c7 (triheme)" RELATED [] synonym: "cytochrome d" RELATED [] synonym: "diheme class I cytochrome c" RELATED [] synonym: "electron transfer carrier" RELATED [] synonym: "flavin-containing electron transporter" RELATED [] synonym: "flavodoxin" RELATED [] synonym: "high-molecular-weight cytochrome c (hexadecaheme)" RELATED [] synonym: "monoheme class I cytochrome c" RELATED [] synonym: "nonaheme cytochrome c" RELATED [] synonym: "respiratory chain cytochrome b6" RELATED [] synonym: "Rieske iron-sulfur protein" RELATED [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0005490 name: cytochrome P450 namespace: molecular_function def: "OBSOLETE. A cytochrome b that has a sulfur atom ligated to the iron of the prosthetic group (heme-thiolate); enzymes:typically monooxygenases acting on lipophilic substrates." [ISBN:0198547684] comment: This term was made obsolete because its definition was changed and because it represents a gene product. is_obsolete: true [Term] id: GO:0005496 name: steroid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0008289 ! lipid binding [Term] id: GO:0005497 name: androgen binding namespace: molecular_function def: "Interacting selectively and non-covalently with any androgen, male sex hormones." [GOC:jl, http://cancerweb.ncl.ac.uk/] is_a: GO:0005496 ! steroid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005499 name: vitamin D binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin D, any of a group of related, fat-soluble compounds that are derived from delta-5,7 steroids and play a central role in calcium metabolism. Specific forms of vitamin D include calciferol (ergocalciferol; vitamin D2) and cholecalciferol (calciol; vitamin D3)." [ChEBI:27300, GOC:mah, ISBN:0471331309] synonym: "calciferol binding" NARROW [] synonym: "cholecalciferol binding" NARROW [] synonym: "ergocalciferol binding" NARROW [] is_a: GO:0005496 ! steroid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005500 name: juvenile hormone binding namespace: molecular_function def: "Interacting selectively and non-covalently with juvenile hormone, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0005501 name: retinoid binding namespace: molecular_function def: "Interacting selectively and non-covalently with retinoids, any member of a class of isoprenoids that contain or are derived from four prenyl groups linked head-to-tail. Retinoids include retinol and retinal and structurally similar natural derivatives or synthetic compounds, but need not have vitamin A activity." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019840 ! isoprenoid binding [Term] id: GO:0005502 name: 11-cis retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with 11-cis retinal, an isomer of retinal that plays an important role in the visual process in most vertebrates. 11-cis retinal combines with opsin in the rods (scotopsin) to form rhodopsin or visual purple. Retinal is one of the three compounds that makes up vitamin A." [http://cancerweb.ncl.ac.uk/] synonym: "11-cis retinaldehyde binding" EXACT [] synonym: "vitamin A binding" BROAD [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005503 name: all-trans retinal binding namespace: molecular_function def: "Interacting selectively and non-covalently with all-trans retinal, a compound that plays an important role in the visual process in most vertebrates. All-trans retinal (trans r., visual yellow) results from the bleaching of rhodopsin by light, in which the 11-cis form is converted to the all-trans form. Retinal is one of the forms of vitamin A." [http://cancerweb.ncl.ac.uk/] synonym: "all-trans retinaldehyde binding" EXACT [] synonym: "trans retinal binding" EXACT [] synonym: "visual yellow binding" EXACT [] synonym: "vitamin A binding" BROAD [] synonym: "xanthopsin" RELATED [] is_a: GO:0016918 ! retinal binding [Term] id: GO:0005504 name: fatty acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008289 ! lipid binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0005505 name: heavy metal binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with a heavy metal, a metal that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0046872 [Term] id: GO:0005506 name: iron ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with iron (Fe) ions." [GOC:ai] subset: gosubset_prok synonym: "iron binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005507 name: copper ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with copper (Cu) ions." [GOC:ai] subset: gosubset_prok synonym: "copper binding" EXACT [] synonym: "copper/cadmium binding" BROAD [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0005508 name: copper/cadmium binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a composite function. is_obsolete: true consider: GO:0005507 consider: GO:0046870 [Term] id: GO:0005509 name: calcium ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with calcium ions (Ca2+)." [GOC:ai] subset: goslim_generic subset: gosubset_prok synonym: "calcium ion storage activity" RELATED [] xref: Reactome:15962 "calcium ion binding" is_a: GO:0046872 ! metal ion binding [Term] id: GO:0005513 name: detection of calcium ion namespace: biological_process def: "The series of events in which a calcium ion stimulus is received by a cell and converted into a molecular signal." [GOC:pg] synonym: "Ca2+ ion detection" EXACT [] synonym: "calcium ion detection" EXACT [] synonym: "calcium ion sensing" EXACT [] synonym: "detection of Ca2+ ion" EXACT [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0051592 ! response to calcium ion [Term] id: GO:0005514 name: calcium ion storage activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0005509 replaced_by: GO:0051208 [Term] id: GO:0005515 name: protein binding namespace: molecular_function alt_id: GO:0045308 def: "Interacting selectively and non-covalently with any protein or protein complex (a complex of two or more proteins that may include other nonprotein molecules)." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "alpha-2 macroglobulin receptor-associated protein activity" RELATED [] synonym: "protein amino acid binding" EXACT [] synonym: "protein degradation tagging activity" RELATED [] synonym: "protein folding chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "protein tagging activity" RELATED [] xref: Reactome:6125 "protein binding" is_a: GO:0005488 ! binding [Term] id: GO:0005516 name: calmodulin binding namespace: molecular_function def: "Interacting selectively and non-covalently with calmodulin, a calcium-binding protein with many roles, both in the calcium-bound and calcium-free states." [GOC:krc] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0005517 name: calmodulin inhibitor activity namespace: molecular_function def: "OBSOLETE. This term was not defined before being made obsolete." [GOC:tb] comment: This term was made obsolete because it refers to a non-existent molecular function term, 'calmodulin activity'. is_obsolete: true consider: GO:0005516 [Term] id: GO:0005518 name: collagen binding namespace: molecular_function def: "Interacting selectively and non-covalently with collagen, a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005515 ! protein binding [Term] id: GO:0005519 name: cytoskeletal regulatory protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein involved in modulating the reorganization of the cytoskeleton." [GOC:go_curators, PMID:15163540] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005520 name: insulin-like growth factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with an insulin-like growth factor, any member of a group of polypeptides that are structurally homologous to insulin and share many of its biological activities, but are immunologically distinct from it." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "IGF binding" EXACT [] is_a: GO:0019838 ! growth factor binding [Term] id: GO:0005521 name: lamin binding namespace: molecular_function def: "Interacting selectively and non-covalently with lamin; any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lamin/chromatin binding" BROAD [] is_a: GO:0005515 ! protein binding [Term] id: GO:0005522 name: profilin binding namespace: molecular_function def: "Interacting selectively and non-covalently with profilin, an actin-binding protein that forms a complex with G-actin and prevents it from polymerizing to form F-actin." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0005515 ! protein binding [Term] id: GO:0005523 name: tropomyosin binding namespace: molecular_function def: "Interacting selectively and non-covalently with tropomyosin, a protein associated with actin filaments both in cytoplasm and, in association with troponin, in the thin filament of striated muscle." [http://cancerweb.ncl.ac.uk/] is_a: GO:0008092 ! cytoskeletal protein binding [Term] id: GO:0005524 name: ATP binding namespace: molecular_function def: "Interacting selectively and non-covalently with ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:1403 "ATP binding" is_a: GO:0032559 ! adenyl ribonucleotide binding [Term] id: GO:0005525 name: GTP binding namespace: molecular_function def: "Interacting selectively and non-covalently with GTP, guanosine triphosphate." [GOC:ai] subset: gosubset_prok xref: Reactome:12514 "GTP binding" is_a: GO:0032561 ! guanyl ribonucleotide binding [Term] id: GO:0005527 name: macrolide binding namespace: molecular_function def: "Interacting selectively and non-covalently with a macrolide, any of a large group of structurally related antibiotics produced by Streptomyces species." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008144 ! drug binding [Term] id: GO:0005528 name: FK506 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the immunosuppressant FK506." [GOC:jl] synonym: "FK506-sensitive peptidyl-prolyl cis-trans isomerase" RELATED [] is_a: GO:0005527 ! macrolide binding [Term] id: GO:0005529 name: sugar binding namespace: molecular_function def: "Interacting selectively and non-covalently with any mono-, di- or trisaccharide carbohydrate." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030246 ! carbohydrate binding [Term] id: GO:0005530 name: lectin namespace: molecular_function def: "OBSOLETE. Lectins are proteins obtained particularly from the seeds of leguminous plants, but also from many other plant and animal sources, that have binding sites for specific mono or oligosaccharides in cell walls or membranes. They thereby change the physiology of the membrane to cause agglutination, mitosis, or other biochemical changes in the cell." [http://cancerweb.ncl.ac.uk/] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005529 consider: GO:0007157 [Term] id: GO:0005531 name: galactose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0005534 consider: GO:0007157 [Term] id: GO:0005532 name: mannose binding lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "mannose receptor" RELATED [] is_obsolete: true consider: GO:0005537 consider: GO:0007157 [Term] id: GO:0005533 name: N-acetylgalactosamine lectin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true consider: GO:0007157 consider: GO:0046871 [Term] id: GO:0005534 name: galactose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the aldohexose galactose (galacto-hexose), a common constituent of many oligo- and polysaccharides." [ChEBI:28260, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005536 name: glucose binding namespace: molecular_function def: "Interacting selectively and non-covalently with the D- or L-enantiomer of glucose." [ChEBI:17234, GOC:jl] subset: gosubset_prok is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005537 name: mannose binding namespace: molecular_function def: "Interacting selectively and non-covalently with mannose, a monosaccharide hexose, stereoisomeric with glucose, that occurs naturally only in polymerized forms called mannans." [ChEBI:37684, GOC:jl, ISBN:0192800981] subset: gosubset_prok synonym: "mannose binding lectin" RELATED [] is_a: GO:0048029 ! monosaccharide binding [Term] id: GO:0005539 name: glycosaminoglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with any glycan (polysaccharide) containing a substantial proportion of aminomonosaccharide residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0005540 name: hyaluronic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with hyaluronic acid, a polymer composed of repeating dimeric units of glucuronic acid and N-acetyl glucosamine." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "hyaluronan binding" EXACT [] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0005541 name: acyl-CoA or acyl binding namespace: molecular_function def: "OBSOLETE. Interacting selectively with acyl-CoA or acyl, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty acyl group, or any group formally derived by removal of a hydroxyl group from the acid function of an organic acid." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it was replaced by more appropriate terms. is_obsolete: true consider: GO:0000035 consider: GO:0000062 [Term] id: GO:0005542 name: folic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with folic acid, pteroylglutamic acid. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "folate binding" EXACT [] synonym: "vitamin B9 binding" EXACT [] synonym: "vitamin M binding" EXACT [] is_a: GO:0016597 ! amino acid binding is_a: GO:0019842 ! vitamin binding [Term] id: GO:0005543 name: phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0008289 ! lipid binding [Term] id: GO:0005544 name: calcium-dependent phospholipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with phospholipids, a class of lipids containing phosphoric acid as a mono- or diester, in the presence of calcium." [GOC:jl] subset: gosubset_prok is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0005545 name: phosphatidylinositol binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0035091 ! phosphoinositide binding [Term] id: GO:0005546 name: phosphatidylinositol-4,5-bisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-4,5-bisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 4' and 5' positions." [GOC:bf, GOC:jl] is_a: GO:0035091 ! phosphoinositide binding [Term] id: GO:0005547 name: phosphatidylinositol-3,4,5-trisphosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-3,4,5-trisphosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3', 4' and 5' positions." [GOC:bf, GOC:jl] is_a: GO:0035091 ! phosphoinositide binding [Term] id: GO:0005548 name: phospholipid transporter activity namespace: molecular_function alt_id: GO:0008497 def: "Enables the directed movement of phospholipids into, out of, within or between cells. Phospholipids are a class of lipids containing phosphoric acid as a mono- or diester." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:7040 "phospholipid transporter activity" is_a: GO:0005319 ! lipid transporter activity relationship: part_of GO:0015914 ! phospholipid transport [Term] id: GO:0005549 name: odorant binding namespace: molecular_function def: "Interacting selectively and non-covalently with an odorant, any substance capable of stimulating the sense of smell." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0005550 name: pheromone binding namespace: molecular_function def: "Interacting selectively and non-covalently with a pheromone, a substance, or characteristic mixture of substances, that is secreted and released by an organism and detected by a second organism of the same or a closely related species, in which it causes a specific reaction, such as a definite behavioral reaction or a developmental process." [GOC:ai] is_a: GO:0005549 ! odorant binding [Term] id: GO:0005551 name: ubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0016567 consider: GO:0031386 [Term] id: GO:0005552 name: polyubiquitin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true consider: GO:0000209 [Term] id: GO:0005553 name: ubiquitin-ribosomal protein fusion protein namespace: molecular_function def: "OBSOLETE. A protein encoded by some ubiquitin genes which consists of a single copy of ubiquitin fused to a ribosomal protein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it describes a gene product. is_obsolete: true [Term] id: GO:0005555 name: blood group antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005557 name: lymphocyte antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005558 name: minor histocompatibility antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0005559 name: ribozyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005561 name: nucleic acid namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005562 name: RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005563 name: transfer RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030533 [Term] id: GO:0005564 name: cytosolic tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005565 name: mitochondrial tRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005566 name: ribosomal RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0003735 consider: GO:0005840 [Term] id: GO:0005567 name: cytosolic ribosomal RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005568 name: mitochondrial rRNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO rather than being made obsolete and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005569 name: small nucleolar RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0030555 [Term] id: GO:0005570 name: small nuclear RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents gene products. is_obsolete: true consider: GO:0000375 consider: GO:0017069 [Term] id: GO:0005571 name: untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005572 name: RNA polymerase II transcribed untranslated RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005573 name: telomerase RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0000332 [Term] id: GO:0005574 name: DNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: Note that this term was deleted from GO and was restored to the ontology in Feb 2003 to ensure that the ID is not reused. is_obsolete: true [Term] id: GO:0005575 name: cellular_component namespace: cellular_component alt_id: GO:0008372 def: "The part of a cell or its extracellular environment in which a gene product is located. A gene product may be located in one or more parts of a cell and its location may be as specific as a particular macromolecular complex, that is, a stable, persistent association of macromolecules that function together." [GOC:go_curators] comment: Note that, in addition to forming the root of the cellular component ontology, this term is recommended for use for the annotation of gene products whose cellular component is unknown. Note that when this term is used for annotation, it indicates that no information was available about the cellular component of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cellular component" EXACT [] synonym: "cellular component unknown" NARROW [] xref: NIF_Subcellular:sao1337158144 disjoint_from: GO:0003674 ! molecular_function [Term] id: GO:0005576 name: extracellular region namespace: cellular_component def: "The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite." [GOC:go_curators] comment: Note that this term is intended to annotate gene products that are not uniformly attached to the cell surface. For gene products from multicellular organisms which are secreted from a cell but retained within the organism (i.e. released into the interstitial fluid or blood), consider the cellular component term 'extracellular space ; GO:0005615'. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "extracellular" EXACT [] xref: Wikipedia:Extracellular is_a: GO:0005575 ! cellular_component [Term] id: GO:0005577 name: fibrinogen complex namespace: cellular_component def: "A highly soluble, elongated protein complex found in blood plasma and involved in clot formation. It is converted into fibrin monomer by the action of thrombin. In the mouse, fibrinogen is a hexamer, 46 nm long and 9 nm maximal diameter, containing two sets of nonidentical chains (alpha, beta, and gamma) linked together by disulfide bonds." [ISBN:0198547684] synonym: "fibrinogen" EXACT [] synonym: "fibrinogen alpha chain" NARROW [] synonym: "fibrinogen beta chain" NARROW [] synonym: "fibrinogen gamma chain" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005578 name: proteinaceous extracellular matrix namespace: cellular_component def: "A layer consisting mainly of proteins (especially collagen) and glycosaminoglycans (mostly as proteoglycans) that forms a sheet underlying or overlying cells such as endothelial and epithelial cells. The proteins are secreted by cells in the vicinity. An example of this component is found in Mus musculus." [GOC:mtg_sensu, ISBN:0198547684] subset: goslim_generic subset: goslim_goa subset: goslim_plant is_a: GO:0031012 ! extracellular matrix [Term] id: GO:0005579 name: membrane attack complex namespace: cellular_component def: "A protein complex produced by sequentially activated components of the complement cascade inserted into a target cell membrane and forming a pore leading to cell lysis via ion and water flow." [GOC:add, ISBN:0198547684, ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] synonym: "MAC" EXACT [] synonym: "membrane attack complex protein alphaM chain" NARROW [] synonym: "membrane attack complex protein beta2 chain" NARROW [] synonym: "TCC" EXACT [] synonym: "terminal complement complex" EXACT [] xref: Wikipedia:Complement_membrane_attack_complex is_a: GO:0044459 ! plasma membrane part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005580 name: membrane attack complex protein alphaM chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0005581 name: collagen namespace: cellular_component def: "Any of the various assemblies in which collagen chains form a left-handed triple helix; may assemble into higher order structures." [GOC:mah, ISBN:0721639976] synonym: "other collagen" RELATED [] xref: Wikipedia:Collagen is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005582 name: collagen type XV namespace: cellular_component def: "A collagen homotrimer of alpha1(XV) chains; a chondroitin sulfate proteoglycan often found in specialized basement membranes." [PMID:11158616, PMID:11937714] is_a: GO:0005581 ! collagen [Term] id: GO:0005583 name: fibrillar collagen namespace: cellular_component def: "Any collagen polymer in which collagen triple helices associate to form fibrils." [GOC:mah, ISBN:0721639976] is_a: GO:0005581 ! collagen [Term] id: GO:0005584 name: collagen type I namespace: cellular_component def: "A collagen trimer containing alpha(I) chains. The most common form of type I collagen is a heterotrimer containing two alpha1(I) chains and one alpha2(I) chain; homotrimers containing three alpha1(I) chains are also found. Type I collagen triple helices associate to form banded fibrils." [GOC:mah, GOC:sl, ISBN:0721639976] xref: Wikipedia:Collagen_type_I is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005585 name: collagen type II namespace: cellular_component def: "A collagen homotrimer of alpha1(II) chains; type II collagen triple helices associate to form fibrils." [ISBN:0721639976] xref: Wikipedia:Collagen_type_II is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005586 name: collagen type III namespace: cellular_component def: "A collagen homotrimer of alpha1(III) chains; type III collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005587 name: collagen type IV namespace: cellular_component def: "A collagen heterotrimer containing type IV alpha chains; [alpha1(IV)]2alpha2(IV) trimers are commonly observed, although more type IV alpha chains exist and may be present in type IV trimers; type IV collagen triple helices associate to form nets within basement membranes." [ISBN:0721639976] xref: Wikipedia:Collagen_type_IV is_a: GO:0030935 ! sheet-forming collagen relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0005588 name: collagen type V namespace: cellular_component def: "A collagen heterotrimer containing type V alpha chains; [alpha1(V)]2alpha2(V) and alpha1(V)alpha2(V)alpha3(V) trimers have been observed; type V collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005589 name: collagen type VI namespace: cellular_component def: "A collagen heterotrimer containing type VI alpha chains in alpha1(VI)alpha2(VI)alpha3(VI) trimers; type VI collagen triple helices associate to form beaded fibrils." [ISBN:0721639976] is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005590 name: collagen type VII namespace: cellular_component def: "A collagen homotrimer of alpha1(VII) chains; type VII collagen triple helices form antiparallel dimer, which in turn associate laterally to form anchoring fibrils that connect type IV collagen in the basal lamina to plaques in the underlying connective tissue." [ISBN:0721639976] is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005591 name: collagen type VIII namespace: cellular_component def: "A collagen heterotrimer containing type VIII alpha chains; [alpha1(VIII)2]alpha2(VIII) and alpha1(VIII)[alpha2(VIII)]2 trimers have been observed; type VIII collagen triple helices associate to form regular hexagonal nets." [ISBN:0721639976] is_a: GO:0005598 ! short-chain collagen [Term] id: GO:0005592 name: collagen type XI namespace: cellular_component def: "A collagen heterotrimer containing type XI alpha chains in alpha1(XI)alpha2(XI)alpha3(XI) trimers; type XI collagen triple helices associate to form fibrils." [ISBN:0721639976] is_a: GO:0005583 ! fibrillar collagen [Term] id: GO:0005593 name: FACIT collagen namespace: cellular_component def: "Any collagen polymer associated with collagen fibrils and in which the collagen monomers contain two or more relatively short triple-helical domains connected by non-triple-helical sequences; the acronym FACIT stands for fibril-associated collagen with interrupted triple helix." [ISBN:0198599587] xref: Wikipedia:FACIT_collagen is_a: GO:0030934 ! anchoring collagen [Term] id: GO:0005594 name: collagen type IX namespace: cellular_component def: "A collagen heterotrimer containing type IX alpha chains in alpha1(IX)alpha2(IX)alpha3(IX) trimers; type IX collagen triple helices associate to form a structure that links glycosaminoglycans to type II collagen fibrils." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005595 name: collagen type XII namespace: cellular_component def: "A collagen homotrimer of alpha1(XII) chains; type XII collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005596 name: collagen type XIV namespace: cellular_component def: "A collagen homotrimer of alpha1(XIV) chains; type XIV collagen triple helices may link sheet-forming or fibrillar collagens to other structures." [ISBN:0721639976] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005597 name: collagen type XVI namespace: cellular_component def: "A collagen trimer containing alpha(XVI) chains; type XVI trimers can associate with microfibrils." [GOC:mah, PMID:12782140] is_a: GO:0005593 ! FACIT collagen [Term] id: GO:0005598 name: short-chain collagen namespace: cellular_component def: "Any assembly of collagen in which the collagen chains are relatively short compared to the fibrillar collagens." [ISBN:0198599587] is_a: GO:0030935 ! sheet-forming collagen [Term] id: GO:0005599 name: collagen type X namespace: cellular_component def: "A collagen homotrimer of alpha1(X) chains; type X collagen triple helices may form nets." [ISBN:0721639976] is_a: GO:0005598 ! short-chain collagen [Term] id: GO:0005600 name: collagen type XIII namespace: cellular_component def: "A collagen homotrimer of alpha1(XIII) chains; type X collagen triple helices span lipid bilayer membranes." [ISBN:0721639976] is_a: GO:0030936 ! transmembrane collagen [Term] id: GO:0005601 name: classical-complement-pathway C3/C5 convertase complex namespace: cellular_component def: "A heterodimeric protein complex that catalyzes the cleavage of complement components C3 and C5, and acts in the classical pathway of complement activation; consists of one monomer of C2a and one monomer of C4b; C2a is the catalytic subunit, but cannot catalyze cleavage alone." [BRENDA:3.4.21.43, GOC:mah, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Complement.html] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005602 name: complement component C1 complex namespace: cellular_component def: "A protein complex composed of six subunits of C1q, each formed of the three homologous polypeptide chains C1QA, C1QB, and C1QB, and tetramer of two C1QR and two C1QS polypeptide chains." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] synonym: "complement component C1q complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005603 name: complement component C2 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because prior to cleavage, complement component C2 is a single polypeptide rather than a complex, and after cleavage the products do not remain physically associated; there is thus no known biological entitiy corresponding to "complement C2 complex". is_obsolete: true [Term] id: GO:0005604 name: basement membrane namespace: cellular_component def: "A thin layer of dense material found in various animal tissues interposed between the cells and the adjacent connective tissue. It consists of the basal lamina plus an associated layer of reticulin fibers." [ISBN:0198547684] comment: Note that this term has no relationship to 'membrane ; GO:0016020' because the basement membrane is not a lipid bilayer. xref: Wikipedia:Basement_membrane is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005605 name: basal lamina namespace: cellular_component def: "A thin sheet of proteoglycans and glycoproteins, especially laminin, secreted by cells as an extracellular matrix." [ISBN:0198547684] synonym: "basement lamina" EXACT [] xref: NIF_Subcellular:sao1397492660 xref: Wikipedia:Basal_lamina is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005604 ! basement membrane [Term] id: GO:0005606 name: laminin-1 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005607 name: laminin-2 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0005608 name: laminin-3 complex namespace: cellular_component def: "A laminin complex composed of alpha1, beta2 and gamma1 polypeptide chains." [MEDLINE:95005761] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005609 name: laminin-4 complex namespace: cellular_component def: "A laminin complex composed of alpha2, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005610 name: laminin-5 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta3 and gamma2 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005611 name: laminin-6 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta1 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005612 name: laminin-7 complex namespace: cellular_component def: "A laminin complex composed of alpha3, beta2 and gamma1 polypeptide chains." [GOC:jl, PMID:10842354] is_a: GO:0043256 ! laminin complex [Term] id: GO:0005613 name: laminin receptor protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is out of date. It seems to be referring to the non-integrin 34/67kDa laminin receptor, which new research has shown to actually be a ribosomal protein of the SP2 family. is_obsolete: true consider: GO:0008305 [Term] id: GO:0005614 name: interstitial matrix namespace: cellular_component def: "A type of extracellular matrix found in interstitial connective tissue, characterized by the presence of fibronectins, proteoglycans, and types I, III, V, VI, VII and XII collagens." [PMID:8450001] is_a: GO:0005578 ! proteinaceous extracellular matrix [Term] id: GO:0005615 name: extracellular space namespace: cellular_component def: "That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid." [ISBN:0198547684] comment: Note that for multicellular organisms, the extracellular space refers to everything outside a cell, but still within the organism (excluding the extracellular matrix). Gene products from a multi-cellular organism are secreted from a cell into the interstitial fluid or blood can therefore be annotated to this term. subset: goslim_generic subset: goslim_goa subset: goslim_plant synonym: "intercellular space" RELATED [] xref: NIF_Subcellular:sao1425028079 is_a: GO:0044421 ! extracellular region part [Term] id: GO:0005616 name: larval serum protein complex namespace: cellular_component def: "A multisubunit protein complex which, in Drosophila, is a heterohexamer of three subunits, alpha, beta and gamma. The complex is thought to store amino acids for synthesis of adult proteins." [GOC:jl, PMID:6781759] is_a: GO:0043234 ! protein complex is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0005617 name: larval serum protein-1 namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "LSP1" EXACT [] is_obsolete: true [Term] id: GO:0005618 name: cell wall namespace: cellular_component def: "The rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal, and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. In plants it is made of cellulose and, often, lignin; in fungi it is composed largely of polysaccharides; in bacteria it is composed of peptidoglycan." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cell_wall is_a: GO:0030312 ! external encapsulating structure [Term] id: GO:0005619 name: ascospore wall namespace: cellular_component def: "The specialized cell wall of the ascospore (spore), which is the product of meiotic division. Examples of this component are found in Fungi." [GOC:vw, ISBN:0879693568] synonym: "fungal-type spore wall" BROAD [GOC:mah] is_a: GO:0009277 ! fungal-type cell wall is_a: GO:0031160 ! spore wall [Term] id: GO:0005621 name: cellular bud scar namespace: cellular_component def: "Crater-like ring of chitinous scar tissue located on the surface of the mother cell. It is formed after the newly emerged daughter cell separates thereby marking the site of cytokinesis and septation. The number of bud scars that accumulate on the surface of a cell is a useful determinant of replicative age." [GOC:rn, PMID:14600225, PMID:2005820] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009277 ! fungal-type cell wall [Term] id: GO:0005622 name: intracellular namespace: cellular_component def: "The living contents of a cell; the matter contained within (but not including) the plasma membrane, usually taken to exclude large vacuoles and masses of secretory or ingested material. In eukaryotes it includes the nucleus and cytoplasm." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "internal to cell" EXACT [] synonym: "nucleocytoplasm" RELATED [GOC:mah] synonym: "protoplasm" EXACT [] synonym: "protoplast" RELATED [GOC:mah] xref: Wikipedia:Intracellular is_a: GO:0044464 ! cell part [Term] id: GO:0005623 name: cell namespace: cellular_component def: "The basic structural and functional unit of all organisms. Includes the plasma membrane and any external encapsulating structures such as the cell wall and cell envelope." [GOC:go_curators] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao1813327414 xref: Wikipedia:Cell_(biology) is_a: GO:0005575 ! cellular_component [Term] id: GO:0005624 name: membrane fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that includes the plasma and other membranes." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: goslim_candida subset: goslim_yeast subset: gosubset_prok is_a: GO:0005626 ! insoluble fraction [Term] id: GO:0005625 name: soluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "soluble" BROAD [] is_a: GO:0000267 ! cell fraction [Term] id: GO:0005626 name: insoluble fraction namespace: cellular_component def: "That fraction of cells, prepared by disruptive biochemical methods, that is not soluble in water." [GOC:ma] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. subset: gosubset_prok synonym: "particle-bound" RELATED [] is_a: GO:0000267 ! cell fraction [Term] id: GO:0005627 name: ascus namespace: cellular_component def: "OBSOLETE. A sac-like fruiting body (ascomycete Fungi); contains ascospores (typically eight in number)." [ISBN:0198547684] comment: This term was made obsolete because it is a type of cell rather than a cellular component. To update annotations, consider the external ontology term 'ascus ; FAO:0000014'. is_obsolete: true [Term] id: GO:0005628 name: prospore membrane namespace: cellular_component def: "The prospore membrane is a double-membraned structure that extends from the cytoplasmic face of the spindle pole bodies to encompass the spindle pole bodies and the four nuclear lobes that are formed during meiosis. It helps isolate the meiotic nuclei from the cytoplasm during spore formation and serves as a foundation for the formation of the spore walls. An example of this component is found in Schizosaccharomyces pombe." [ISBN:0879693649] subset: gosubset_prok synonym: "ascospore-type prospore membrane" EXACT [GOC:mah] synonym: "forespore membrane" RELATED [] synonym: "FSM" EXACT [] is_a: GO:0016020 ! membrane relationship: part_of GO:0042764 ! ascospore-type prospore [Term] id: GO:0005630 name: dityrosine layer of spore wall namespace: cellular_component def: "The outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005631 name: chitosan layer of spore wall namespace: cellular_component def: "The second outermost layer of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005632 name: inner layer of spore wall namespace: cellular_component def: "Either of the two innermost layers of the spore wall, as described in Saccharomyces." [ISBN:0879693568] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0005619 ! ascospore wall [Term] id: GO:0005633 name: ascus lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in an ascus or ascospore. May include associated proteins." [GOC:mah, PMID:12702293] synonym: "ascus lipid droplet" EXACT [GOC:curators] is_a: GO:0005811 ! lipid particle [Term] id: GO:0005634 name: nucleus namespace: cellular_component def: "A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "cell nucleus" EXACT [] xref: NIF_Subcellular:sao1702920020 xref: Wikipedia:Cell_nucleus is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005635 name: nuclear envelope namespace: cellular_component alt_id: GO:0005636 def: "The double lipid bilayer enclosing the nucleus and separating its contents from the rest of the cytoplasm; includes the intermembrane space, a gap of width 20-40 nm (also called the perinuclear space)." [ISBN:0198547684] subset: goslim_generic subset: goslim_plant xref: Wikipedia:Nuclear_envelope is_a: GO:0031967 ! organelle envelope is_a: GO:0044428 ! nuclear part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005637 name: nuclear inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the nuclear envelope." [GOC:ma] synonym: "inner envelope" BROAD [] xref: NIF_Subcellular:sao1612527463 is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031965 ! nuclear membrane [Term] id: GO:0005638 name: lamin filament namespace: cellular_component def: "Any of a group of intermediate-filament proteins that form the fibrous matrix on the inner surface of the nuclear envelope. They are classified as lamins A, B and C." [ISBN:0198547684] synonym: "type V intermediate filament" EXACT [] is_a: GO:0005882 ! intermediate filament is_a: GO:0044428 ! nuclear part intersection_of: GO:0005882 ! intermediate filament intersection_of: part_of GO:0005652 ! nuclear lamina relationship: part_of GO:0005652 ! nuclear lamina [Term] id: GO:0005639 name: integral to nuclear inner membrane namespace: cellular_component def: "Located such that some or all of the gene product itself penetrates at least one phospholipid bilayer of the nuclear inner membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] is_a: GO:0031229 ! intrinsic to nuclear inner membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0005640 name: nuclear outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the nuclear envelope; continuous with the endoplasmic reticulum of the cell and sometimes studded with ribosomes." [ISBN:0198547684] synonym: "outer envelope" BROAD [] synonym: "perinuclear membrane" EXACT [] xref: NIF_Subcellular:sao1617136075 is_a: GO:0031965 ! nuclear membrane is_a: GO:0031968 ! organelle outer membrane is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear membrane-endoplasmic reticulum network [Term] id: GO:0005641 name: nuclear envelope lumen namespace: cellular_component alt_id: GO:0005653 def: "The region between the two lipid bilayers of the nuclear envelope; 20-40 nm wide." [GOC:ai] comment: Note that this term should not be confused with the cellular component term 'perinuclear region ; GO:0048471'. synonym: "nuclear intermembrane space" EXACT [] synonym: "nuclear membrane lumen" RELATED [] synonym: "perinuclear space" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044428 ! nuclear part relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005642 name: annulate lamellae namespace: cellular_component def: "Stacks of endoplasmic reticulum (ER) membranes containing a high density of nuclear pores, thought to form from excess nuclear membrane components, that have been described in a number of different cells. Annulate lamellar membranes are continuous with and embedded within the ER." [PMID:12631728] is_a: GO:0044425 ! membrane part relationship: part_of GO:0042175 ! nuclear membrane-endoplasmic reticulum network [Term] id: GO:0005643 name: nuclear pore namespace: cellular_component alt_id: GO:0005644 def: "Any of the numerous similar discrete openings in the nuclear envelope of a eukaryotic cell, where the inner and outer nuclear membranes are joined." [ISBN:0198547684] subset: goslim_pir synonym: "NPC" EXACT [] synonym: "nuclear pore complex" EXACT [] synonym: "nuclear pore membrane protein" NARROW [] xref: NIF_Subcellular:sao220861693 xref: Wikipedia:Nuclear_pore is_a: GO:0044428 ! nuclear part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005635 ! nuclear envelope [Term] id: GO:0005645 name: RAN-binding protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0008536 consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005646 name: importin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005647 name: importin, alpha-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-alpha" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005648 name: importin, beta-subunit namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta1" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005649 name: transportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "karyopherin-beta2" EXACT [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005650 name: importin, alpha-subunit transport factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. synonym: "CAS" RELATED [] is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005651 name: exportin namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005634 consider: GO:0005643 consider: GO:0005737 [Term] id: GO:0005652 name: nuclear lamina namespace: cellular_component def: "The fibrous, electron-dense layer lying on the nucleoplasmic side of the inner membrane of a cell nucleus, composed of lamin filaments. The polypeptides of the lamina are thought to be concerned in the dissolution of the nuclear envelope and its re-formation during mitosis. The lamina is composed of lamin A and lamin C filaments cross-linked into an orthogonal lattice, which is attached via lamin B to the inner nuclear membrane through interactions with a lamin B receptor, an IFAP, in the membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] xref: NIF_Subcellular:sao1455996588 xref: Wikipedia:Nuclear_lamina is_a: GO:0044428 ! nuclear part relationship: part_of GO:0034399 ! nuclear periphery [Term] id: GO:0005654 name: nucleoplasm namespace: cellular_component def: "That part of the nuclear content other than the chromosomes or the nucleolus." [GOC:ma, ISBN:0124325653] subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao661522542 xref: Wikipedia:Nucleoplasm is_a: GO:0044428 ! nuclear part relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005655 name: nucleolar ribonuclease P complex namespace: cellular_component def: "A ribonuclease P complex located in the nucleolus of a eukaryotic cell, where it catalyzes the 5' endonucleolytic cleavage of precursor tRNAs to yield mature tRNAs. Eukaryotic nucleolar ribonuclease P complexes generally contain a single RNA molecule that is necessary but not sufficient for catalysis, and several protein molecules." [GOC:mah, PMID:12045094] synonym: "nucleolar RNase P complex" EXACT [] is_a: GO:0030681 ! multimeric ribonuclease P complex is_a: GO:0044452 ! nucleolar part intersection_of: GO:0030677 ! ribonuclease P complex intersection_of: part_of GO:0005730 ! nucleolus [Term] id: GO:0005656 name: pre-replicative complex namespace: cellular_component def: "A protein-DNA complex assembled at eukaryotic DNA replication origins during late mitosis and G1, allowing the origin to become competent, or 'licensed', for replication. The complex normally includes the origin recognition complex (ORC), Cdc6, Cdt1 and the MiniChromosome Maintenance (Mcm2-7) proteins." [PMID:15222894] synonym: "pre-RC" EXACT [] is_a: GO:0032993 ! protein-DNA complex is_a: GO:0044451 ! nucleoplasm part relationship: has_part GO:0000808 ! origin recognition complex relationship: has_part GO:0042555 ! MCM complex [Term] id: GO:0005657 name: replication fork namespace: cellular_component def: "The Y-shaped region of a replicating DNA molecule, resulting from the separation of the DNA strands and in which the synthesis of new strands takes place. Also includes associated protein complexes." [GOC:mah, ISBN:0198547684] subset: gosubset_prok synonym: "replication focus" RELATED [] xref: Wikipedia:Replication_fork is_a: GO:0044427 ! chromosomal part [Term] id: GO:0005658 name: alpha DNA polymerase:primase complex namespace: cellular_component def: "A complex of four polypeptides, comprising large and small DNA polymerase alpha subunits and two primase subunits, which catalyzes the synthesis of an RNA primer on the lagging strand of replicating DNA; the smaller of the two primase subunits alone can catalyze oligoribonucleotide synthesis." [GOC:mah, PMID:11395402] synonym: "DNA polymerase alpha:primase complex" EXACT [] synonym: "heterotetrameric polymerase alpha holoenzyme" EXACT [] synonym: "pol-prim" RELATED [] synonym: "primosome" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005660 name: delta-DNA polymerase cofactor complex namespace: cellular_component def: "OBSOLETE. A complex of proteins that interacts with delta-DNA polymerase, promoting elongation. In humans it is a heteropentamer of subunits of 140/145, 40, 38, 37 and 36.5 kDa, which form a complex with the proliferating cell nuclear antigen (PCNA) in the presence of ATP." [GOC:jl] comment: This term was made obsolete because it refers to two distinct complexes, PCNA and Replication factor C (RFC), the latter of which is already represented as a separate, unrelated GO term (DNA replication factor C complex ; GO:0005663). In addition, the phrase 'delta-DNA polymerase cofactor' to represent both PCNA and RFC is not used in current literature. synonym: "delta DNA polymerase cofactor complex" EXACT [] is_obsolete: true replaced_by: GO:0005663 replaced_by: GO:0043626 [Term] id: GO:0005662 name: DNA replication factor A complex namespace: cellular_component def: "A conserved heterotrimeric complex that binds nonspecifically to single-stranded DNA and is required for multiple processes in eukaryotic DNA metabolism, including DNA replication, DNA repair, and recombination. In all eukaryotic organisms examined the complex is composed of subunits of approximately 70, 30, and 14 kDa." [PMID:9242902] synonym: "replication protein A" EXACT [] synonym: "RPA" EXACT [] synonym: "single-stranded DNA-binding protein complex" RELATED [] synonym: "SSB" RELATED [] xref: Wikipedia:Replication_protein_A is_a: GO:0043234 ! protein complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0005663 name: DNA replication factor C complex namespace: cellular_component def: "A complex of five polypeptides in eukaryotes, and two in prokaryotes, that loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA, thereby permitting processive DNA synthesis catalyzed by DNA polymerase." [PMID:14614842, PMID:14646196, PMID:16172520] subset: goslim_pir subset: gosubset_prok synonym: "activator 1 complex" EXACT [] synonym: "RFC complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005657 ! replication fork [Term] id: GO:0005664 name: nuclear origin of replication recognition complex namespace: cellular_component def: "A multisubunit complex that is located at the replication origins of a chromosome in the nucleus." [GOC:elh] synonym: "eukaryotic ORC" EXACT [] synonym: "nuclear ORC" EXACT [] is_a: GO:0000808 ! origin recognition complex is_a: GO:0044454 ! nuclear chromosome part [Term] id: GO:0005665 name: DNA-directed RNA polymerase II, core complex namespace: cellular_component def: "RNA polymerase II, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces mRNAs, snoRNAs, and some of the snRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The largest subunit of RNA polymerase II contains an essential carboxyl-terminal domain (CTD) composed of a variable number of heptapeptide repeats (YSPTSPS). The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerases I and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "RNA polymerase II complex" BROAD [] synonym: "RNAP II complex" BROAD [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex intersection_of: GO:0000428 ! DNA-directed RNA polymerase complex intersection_of: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005666 name: DNA-directed RNA polymerase III complex namespace: cellular_component def: "RNA polymerase III, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces 5S rRNA, tRNAs and some of the small nuclear RNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase I and others of which are also found in RNA polymerases I and II. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase III activity" RELATED [] is_a: GO:0044451 ! nucleoplasm part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005667 name: transcription factor complex namespace: cellular_component def: "A protein complex, distinct from RNA polymerase, that associates with DNA at promoters or at cis-acting regulatory sequences, by direct binding or by interaction with other DNA-binding polypeptides or complexes, and regulates transcription." [GOC:mah] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005668 name: RNA polymerase transcription factor SL1 complex namespace: cellular_component def: "A RNA polymerase I-specific transcription factor complex that contains the TATA-box-binding protein (TBP) and at least three TBP-associated factors including proteins known in mammals as TAFI110, TAFI63 and TAFI48." [PMID:15691654] synonym: "selectivity factor SL1 complex" EXACT [GOC:mah] synonym: "TIF-IB" EXACT [CORUM:480, PMID:15691654] is_a: GO:0000120 ! RNA polymerase I transcription factor complex [Term] id: GO:0005669 name: transcription factor TFIID complex namespace: cellular_component def: "A complex composed of TATA binding protein (TBP) and TBP associated factors (TAFs); the total mass is typically about 800 kDa. Most of the TAFs are conserved across species. In TATA-containing promoters for RNA polymerase II (Pol II), TFIID is believed to recognize at least two distinct elements, the TATA element and a downstream promoter element. TFIID is also involved in recognition of TATA-less Pol II promoters. Binding of TFIID to DNA is necessary but not sufficient for transcription initiation from most RNA polymerase II promoters." [GOC:krc, GOC:mah, ISBN:0471953393, ISBN:0879695501] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005670 name: transcription-activating factor, 30kD namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005669 [Term] id: GO:0005671 name: Ada2/Gcn5/Ada3 transcription activator complex namespace: cellular_component def: "A multiprotein complex that possesses histone acetyltransferase and is involved in regulation of transcription. The budding yeast complex includes Gcn5p, two proteins of the Ada family, and two TBP-associate proteins (TAFs); analogous complexes in other species have analogous compositions, and usually contain homologs of the yeast proteins." [PMID:10637607] is_a: GO:0000123 ! histone acetyltransferase complex [Term] id: GO:0005672 name: transcription factor TFIIA complex namespace: cellular_component def: "A component of the transcription machinery of RNA Polymerase II. In humans, TFIIA is a heterotrimer composed of an alpha (P35), beta (P19) and gamma subunits (P12)." [GOC:jl, PMID:17560669] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005673 name: transcription factor TFIIE complex namespace: cellular_component def: "A transcription factor which in humans consists of a complex of two alpha and two beta chains. Recruits TFIIH to the initiation complex and helps activate both RNA polymerase II and TFIIH." [GOC:jl, PMID:16547462] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005674 name: transcription factor TFIIF complex namespace: cellular_component def: "A general transcription initiation factor which in humans consists of a heterodimer of an alpha and a beta subunit. Helps recruit RNA polymerase II to the initiation complex and promotes translation elongation." [GOC:jl, PMID:7597077] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005675 name: holo TFIIH complex namespace: cellular_component def: "A complex that contains kinase activity directed towards the C-terminal Domain (CTD) of the largest subunit of RNA polymerase II and is essential for initiation at RNA polymerase II promoters in vitro. In S. cerevisiae, it is composed of the 5-subunit core (Rad3p, Tfb1p, Tfb2p, Ssl1p and Tfb4p), Ssl2p, and TFIIK (Kin28p, Ccl1p, and Tfb3p). All of the subunits have equivalents in humans: the 5 subunit core is composed of ERCC2, p62, p55, p44, p34; the equivalent of the TFIIK subcomplex is composed of MO15, Mat1, and a cyclin; the human equivalent of Ssl2p is XPB." [GOC:krc, PMID:14500720, PMID:7813015] is_a: GO:0005667 ! transcription factor complex relationship: part_of GO:0016591 ! DNA-directed RNA polymerase II, holoenzyme [Term] id: GO:0005677 name: chromatin silencing complex namespace: cellular_component def: "Any protein complex that mediates changes in chromatin structure that result in transcriptional silencing." [GOC:mah] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0005678 name: chromatin assembly complex namespace: cellular_component def: "Any protein complex that acts in the formation of nucleosomes or higher order chromatin structure." [GOC:mah] synonym: "nucleosome assembly complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005680 name: anaphase-promoting complex namespace: cellular_component def: "A ubiquitin ligase complex that degrades mitotic cyclins and anaphase inhibitory protein, thereby triggering sister chromatid separation and exit from mitosis. Substrate recognition by APC occurs through degradation signals, the most common of which is termed the Dbox degradation motif, originally discovered in cyclin B." [GOC:jh, PMID:10465783, PMID:10611969] comment: Note that the synonym 'APC' should not be confused with the abbreviation for the adenomatous polyposis coli gene and protein. synonym: "anaphase promoting complex" EXACT [] synonym: "APC" BROAD [] synonym: "cyclosome" EXACT [] xref: Wikipedia:Anaphase-promoting_complex is_a: GO:0000152 ! nuclear ubiquitin ligase complex [Term] id: GO:0005681 name: spliceosomal complex namespace: cellular_component def: "Any of a series of ribonucleoprotein complexes that contain RNA and small nuclear ribonucleoproteins (snRNPs), and are formed sequentially during the splicing of a messenger RNA primary transcript to excise an intron." [GOC:mah, ISBN:0198547684, PMID:19239890] subset: goslim_pir synonym: "spliceosome complex" EXACT [] xref: Wikipedia:Spliceosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005682 name: U5 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U5." [GOC:krc, GOC:mah] synonym: "snRNP U5" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005683 name: U7 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains the U7 snRNA and is required for the 3'-end processing of replication-dependent histone pre-mRNAs." [PMID:12872004] synonym: "snRNP U7" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005684 name: U2-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron that has canonical consensus sequences near the 5' and 3' ends." [GOC:krc, GOC:mah, PMID:11343900] synonym: "GT-AG spliceosome" NARROW [GOC:krc, GOC:mah] synonym: "major (U2-type) spliceosomal complex" EXACT [GOC:krc, GOC:mah] synonym: "major spliceosomal complex" EXACT [GOC:krc, GOC:mah] is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005685 name: U1 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U1." [GOC:krc, GOC:mah] synonym: "snRNP U1" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005686 name: U2 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U2." [GOC:krc, GOC:mah] synonym: "17S U2 snRNP" NARROW [] synonym: "snRNP U2" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005687 name: U4 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4." [GOC:krc, GOC:mah] synonym: "snRNP U4" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005688 name: U6 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6." [GOC:krc, GOC:mah] synonym: "snRNP U6" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005689 name: U12-type spliceosomal complex namespace: cellular_component def: "Any spliceosomal complex that forms during the splicing of a messenger RNA primary transcript to excise an intron; the series of U12-type spliceosomal complexes is involved in the splicing of the majority of introns that contain atypical AT-AC terminal dinucleotides, as well as other non-canonical introns. The entire splice site signal, not just the terminal dinucleotides, is involved in determining which spliceosome utilizes the site." [GOC:krc, GOC:mah, PMID:11574683, PMID:11971955] synonym: "AT-AC spliceosomal complex" NARROW [GOC:krc, GOC:mah] synonym: "minor (U12-type) spliceosomal complex" EXACT [GOC:mah] synonym: "minor spliceosomal complex" EXACT [GOC:krc, GOC:mah] xref: Wikipedia:Minor_spliceosome is_a: GO:0005681 ! spliceosomal complex [Term] id: GO:0005690 name: U4atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U4atac." [GOC:krc, GOC:mah] synonym: "snRNP U4atac" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005691 name: U6atac snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U6atac." [GOC:krc, GOC:mah] synonym: "snRNP U6atac" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005692 name: U11 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U11." [GOC:krc, GOC:mah] synonym: "12S U11 snRNP" NARROW [] synonym: "snRNP U11" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005693 name: U12 snRNP namespace: cellular_component def: "A ribonucleoprotein complex that contains small nuclear RNA U12." [GOC:krc, GOC:mah] synonym: "snRNP U12" EXACT [GOC:mah] is_a: GO:0030532 ! small nuclear ribonucleoprotein complex [Term] id: GO:0005694 name: chromosome namespace: cellular_component def: "A structure composed of a very long molecule of DNA and associated proteins (e.g. histones) that carries hereditary information." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "chromatid" RELATED [] synonym: "interphase chromosome" NARROW [] synonym: "prophase chromosome" NARROW [] xref: Wikipedia:Chromosome is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005695 name: chromatid namespace: cellular_component def: "OBSOLETE. One of the two daughter strands of a duplicated chromosome that become apparent between early prophase and metaphase in mitosis and between diplotene and second metaphase in meiosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is not a unique subcellular component, i.e. the difference between this term and 'chromosome' is based on temporal and process distinctions. is_obsolete: true consider: GO:0000793 consider: GO:0000794 consider: GO:0005694 [Term] id: GO:0005696 name: telomere namespace: cellular_component def: "OBSOLETE. A complex of DNA and protein that seals the end of a chromosome. The telomeric DNA consists of simple tandemly repeated sequences specific for each species. Typically one strand is G-rich and the other C-rich. The G-rich strand forms a 3'-terminal overhang, the length of which varies with species. The single strand overhang is bound by a variety of proteins, including telomere capping proteins that bind to the single-stranded DNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11352055] comment: This term was made obsolete because the definition was too sequence oriented and too restrictive. is_obsolete: true consider: GO:0000781 consider: GO:0000782 [Term] id: GO:0005697 name: telomerase holoenzyme complex namespace: cellular_component def: "Telomerase is a ribonucleoprotein enzyme complex, with a minimal catalytic core composed of a catalytic reverse transcriptase subunit and an RNA subunit that provides the template for telomeric DNA addition. In vivo, the holoenzyme complex often contains additional subunits." [PMID:11884619] subset: goslim_pir is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0005698 name: centromere namespace: cellular_component def: "OBSOLETE. The region of a eukaryotic chromosome that is attached to the spindle during nuclear division. It is defined genetically as the region of the chromosome that always segregates at the first division of meiosis; the region of the chromosome in which no crossing over occurs. At the start of M phase, each chromosome consists of two sister chromatids with a constriction at a point which forms the centromere. During late prophase two kinetochores assemble on each centromere, one kinetochore on each sister chromatid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it is a genetically defined region and not a specific subcellular localization. is_obsolete: true consider: GO:0000775 [Term] id: GO:0005700 name: polytene chromosome namespace: cellular_component def: "A type of chromosome in a polyploid cell, formed when multiple copies of homologous chromosomes are aligned side by side to give a giant chromosome in which distinct chromosome bands are readily visible." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Polytene_chromosome is_a: GO:0005694 ! chromosome [Term] id: GO:0005701 name: polytene chromosome chromocenter namespace: cellular_component def: "A region at which the centric regions of polytene chromosomes are joined together." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome chromocentre" EXACT [] is_a: GO:0010369 ! chromocenter intersection_of: GO:0010369 ! chromocenter intersection_of: part_of GO:0005700 ! polytene chromosome relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005702 name: polytene chromosome weak point namespace: cellular_component def: "A region of the polytene chromosome where the diameter is considerably decreased, probably resulting from local differences in chromosome organization." [GOC:bf, ISBN:0120649012] synonym: "constriction" BROAD [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005703 name: polytene chromosome puff namespace: cellular_component def: "A swelling at a site along the length of a polytene chromosome, thought to be the site of active transcription." [GOC:bf, ISBN:0120649012] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005704 name: polytene chromosome band namespace: cellular_component def: "A stretch of densely packed chromatin along the polytene chromosome, visible as a morphologically distinct band." [GOC:bf, PMID:11361342] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005705 name: polytene chromosome interband namespace: cellular_component def: "A stretch of less tightly packed chromatin along the polytene chromosome, found between bands." [GOC:bf, PMID:11361342] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005706 name: polytene chromosome ectopic fiber namespace: cellular_component def: "A thread-like connection joining two regions of ectopically paired polytene chromosomes." [GOC:bf, ISBN:0120649012] synonym: "polytene chromosome ectopic fibre" EXACT [] is_a: GO:0044427 ! chromosomal part relationship: part_of GO:0005700 ! polytene chromosome [Term] id: GO:0005707 name: interphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during interphase of the cell cycle. Chromosomes are usually decondensed during interphase and each long DNA molecule in a chromosome is divided into a large number of discrete domains that are folded differently." [GOC:ai, ISBN:0815316194] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0005694 [Term] id: GO:0005708 name: mitotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of mitosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005709 name: prophase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during prophase." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0005694 [Term] id: GO:0005710 name: metaphase chromosome namespace: cellular_component def: "OBSOLETE. A chromosome found in the cell during metaphase. Typically, sister chromatids are held together at their centromeres and chromosomes are covered with a large number of molecules, including ribonucleoproteins." [GOC:ai] comment: This term was made obsolete because it is based on a temporal division of the cell cycle. is_obsolete: true consider: GO:0000793 consider: GO:0000794 [Term] id: GO:0005711 name: meiotic chromosome namespace: cellular_component def: "OBSOLETE. A chromosome involved in the process of meiosis." [GOC:ai] comment: This term was made obsolete because it is based on a process. is_obsolete: true consider: GO:0000794 [Term] id: GO:0005712 name: chiasma namespace: cellular_component def: "A connection formed between chromatids, visible during meiosis, thought to be the point of the interchange involved in crossing-over." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Chiasma_(genetics) is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005713 name: recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes." [GOC:elh] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000794 ! condensed nuclear chromosome [Term] id: GO:0005714 name: early recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in leptotene or zygotene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005715 name: late recombination nodule namespace: cellular_component def: "An electron dense structure that is associated with meiotic chromosomes in pachytene during meiosis I." [GOC:elh] is_a: GO:0005713 ! recombination nodule [Term] id: GO:0005719 name: nuclear euchromatin namespace: cellular_component def: "The dispersed less dense form of chromatin in the interphase nucleus. It exists in at least two forms, a some being in the form of transcriptionally active chromatin which is the least condensed, while the rest is inactive euchromatin which is more condensed than active chromatin but less condensed than heterochromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000791 ! euchromatin intersection_of: GO:0000791 ! euchromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005720 name: nuclear heterochromatin namespace: cellular_component def: "A condensed form of chromatin, occurring in the nucleus during interphase, that stains strongly with basophilic dyes. The DNA of heterochromatin is typically replicated at a later stage in the cell-division cycle than euchromatin." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0000790 ! nuclear chromatin is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome [Term] id: GO:0005721 name: centromeric heterochromatin namespace: cellular_component def: "A region of heterochromatin located near the centromere of a chromosome." [PMID:12019236] synonym: "centric heterochromatin" EXACT [] is_a: GO:0000792 ! heterochromatin intersection_of: GO:0000792 ! heterochromatin intersection_of: part_of GO:0000775 ! chromosome, centromeric region relationship: part_of GO:0000775 ! chromosome, centromeric region [Term] id: GO:0005722 name: beta-heterochromatin namespace: cellular_component def: "A diffusely banded region of heterochromatin located between euchromatin and alpha-heterochromatin in the polytene chromosome chromocenter; normally replicated during polytenization." [PMID:11404334, PMID:8878678] is_a: GO:0005721 ! centromeric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005723 name: alpha-heterochromatin namespace: cellular_component def: "A small, compact region of heterochromatin located in the middle of the polytene chromosome chromocenter, which undergoes little or no replication during polytenization." [PMID:8878678] is_a: GO:0005721 ! centromeric heterochromatin relationship: part_of GO:0005701 ! polytene chromosome chromocenter [Term] id: GO:0005724 name: nuclear telomeric heterochromatin namespace: cellular_component def: "Heterochromatic regions of the chromosome found at the telomeres of a chromosome in the nucleus." [GOC:ai] is_a: GO:0005720 ! nuclear heterochromatin is_a: GO:0031933 ! telomeric heterochromatin intersection_of: GO:0031933 ! telomeric heterochromatin intersection_of: part_of GO:0000228 ! nuclear chromosome relationship: part_of GO:0000784 ! nuclear chromosome, telomeric region [Term] id: GO:0005725 name: intercalary heterochromatin namespace: cellular_component def: "Any of the regions of heterochromatin that form a reproducible set of dense bands scattered along the euchromatic arms in polytene chromosomes." [PMID:14579245] is_a: GO:0005720 ! nuclear heterochromatin [Term] id: GO:0005726 name: perichromatin fibrils namespace: cellular_component def: "Structures of variable diameter visible in the nucleoplasm by electron microscopy, mainly observed near the border of condensed chromatin. The fibrils are enriched in RNA, and are believed to be sites of pre-mRNA splicing and polyadenylylation representing the in situ form of nascent transcripts." [PMID:14731598] is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000790 ! nuclear chromatin [Term] id: GO:0005727 name: extrachromosomal circular DNA namespace: cellular_component def: "Circular DNA structures that are not part of a chromosome." [GOC:ai] subset: gosubset_prok is_a: GO:0044424 ! intracellular part relationship: part_of GO:0046821 ! extrachromosomal DNA [Term] id: GO:0005728 name: extrachromosomal rDNA circle namespace: cellular_component def: "Circular DNA molecules encoding ribosomal RNA that are replicated independently of chromosomal replication. These molecules originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats." [GOC:mah, PMID:12044934] synonym: "extrachromosomal ribosomal DNA circle" EXACT [] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005729 name: 2-micrometer circle DNA namespace: cellular_component def: "A plasmid commonly found in Saccharomyces, inherited in a non-Mendelian manner and often present in 100-400 copies." [PMID:12073320] is_a: GO:0005727 ! extrachromosomal circular DNA [Term] id: GO:0005730 name: nucleolus namespace: cellular_component def: "A small, dense body one or more of which are present in the nucleus of eukaryotic cells. It is rich in RNA and protein, is not bounded by a limiting membrane, and is not seen during mitosis. Its prime function is the transcription of the nucleolar DNA into 45S ribosomal-precursor RNA, the processing of this RNA into 5.8S, 18S, and 28S components of ribosomal RNA, and the association of these components with 5S RNA and proteins synthesized outside the nucleolus. This association results in the formation of ribonucleoprotein precursors; these pass into the cytoplasm and mature into the 40S and 60S subunits of the ribosome." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast xref: NIF_Subcellular:sao1820400233 xref: Wikipedia:Nucleolus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044428 ! nuclear part intersection_of: GO:0043232 ! intracellular non-membrane-bounded organelle intersection_of: part_of GO:0031981 ! nuclear lumen relationship: part_of GO:0031981 ! nuclear lumen [Term] id: GO:0005731 name: nucleolus organizer region namespace: cellular_component def: "A region of a chromosome where nucleoli form during interphase, and where genes encoding the largest rRNA precursor transcript are tandemly arrayed." [PMID:14504406] synonym: "NOR" EXACT [] synonym: "nucleolus organiser region" EXACT [] synonym: "nucleolus organizer complex" RELATED [] xref: Wikipedia:Nucleolus_organizer_region is_a: GO:0030874 ! nucleolar chromatin is_a: GO:0043234 ! protein complex [Term] id: GO:0005732 name: small nucleolar ribonucleoprotein complex namespace: cellular_component def: "A ribonucleoprotein complex that contains a small nucleolar RNA (snoRNA) and associated proteins, and is found in eukaryotic cells. Most are involved in a step of processing of rRNA: cleavage, 2'-O-methylation, or pseudouridylation. The majority, though not all, fall into one of two classes, box C/D type or box H/ACA type." [GOC:krc, GOC:mah, ISBN:0879695897] subset: goslim_pir synonym: "small nucleolar ribonucleoprotein" EXACT [] synonym: "snoRNP" EXACT [] is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0005733 name: small nucleolar RNA namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. synonym: "snoRNA" EXACT [] is_obsolete: true [Term] id: GO:0005734 name: box C + D snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005735 name: box H + ACA snoRNP protein namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0005736 name: DNA-directed RNA polymerase I complex namespace: cellular_component def: "RNA polymerase I, one of three nuclear DNA-directed RNA polymerases found in all eukaryotes, is a multisubunit complex; typically it produces rRNAs. Two large subunits comprise the most conserved portion including the catalytic site and share similarity with other eukaryotic and bacterial multisubunit RNA polymerases. The remainder of the complex is composed of smaller subunits (generally ten or more), some of which are also found in RNA polymerase III and others of which are also found in RNA polymerases II and III. Although the core is competent to mediate ribonucleic acid synthesis, it requires additional factors to select the appropriate template." [GOC:krc, GOC:mtg_sensu] synonym: "DNA-directed RNA polymerase I activity" RELATED [] is_a: GO:0044452 ! nucleolar part is_a: GO:0055029 ! nuclear DNA-directed RNA polymerase complex [Term] id: GO:0005737 name: cytoplasm namespace: cellular_component def: "All of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [ISBN:0198547684] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoplasm is_a: GO:0044424 ! intracellular part [Term] id: GO:0005739 name: mitochondrion namespace: cellular_component def: "A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "mitochondria" EXACT [] xref: NIF_Subcellular:sao1860313010 xref: Wikipedia:Mitochondrion is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005740 name: mitochondrial envelope namespace: cellular_component def: "The double lipid bilayer enclosing the mitochondrion and separating its contents from the cell cytoplasm; includes the intermembrane space." [GOC:ai, GOC:pz] subset: goslim_candida subset: goslim_yeast is_a: GO:0031967 ! organelle envelope is_a: GO:0044429 ! mitochondrial part [Term] id: GO:0005741 name: mitochondrial outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the mitochondrial envelope." [GOC:ai] synonym: "outer mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1289741256 xref: Wikipedia:Outer_mitochondrial_membrane is_a: GO:0031966 ! mitochondrial membrane is_a: GO:0031968 ! organelle outer membrane [Term] id: GO:0005742 name: mitochondrial outer membrane translocase complex namespace: cellular_component def: "A large complex of the mitochondrial outer membrane that mediates transport of proteins into all mitochondrial compartments." [PMID:12581629] synonym: "GIP complex" NARROW [] synonym: "TOM complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005741 ! mitochondrial outer membrane [Term] id: GO:0005743 name: mitochondrial inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae." [GOC:ai] synonym: "inner mitochondrial membrane" EXACT [] xref: NIF_Subcellular:sao1371347282 xref: Wikipedia:Inner_mitochondrial_membrane is_a: GO:0019866 ! organelle inner membrane is_a: GO:0031966 ! mitochondrial membrane [Term] id: GO:0005744 name: mitochondrial inner membrane presequence translocase complex namespace: cellular_component def: "The protein transport machinery of the mitochondrial inner membrane that contains three essential Tim proteins: Tim17 and Tim23 are thought to build a preprotein translocation channel while Tim44 interacts transiently with the matrix heat-shock protein Hsp70 to form an ATP-driven import motor." [EC:3.6.3.51, PMID:8851659] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. subset: goslim_pir synonym: "mitochondrial inner membrane pre-sequence translocase complex" EXACT [] synonym: "mitochondrial inner membrane translocase complex" EXACT [] synonym: "Tim23 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005745 name: m-AAA complex namespace: cellular_component def: "Protease complex of the mitochondrial inner membrane that is involved in mitochondrial protein turnover and in processing of proteins imported into mitochondria." [PMID:12417197] is_a: GO:0043234 ! protein complex is_a: GO:0044455 ! mitochondrial membrane part relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005746 name: mitochondrial respiratory chain namespace: cellular_component def: "The protein complexes that form the mitochondrial electron transport system (the respiratory chain), associated with the inner mitochondrial membrane. The respiratory chain complexes transfer electrons from an electron donor to an electron acceptor and are associated with a proton pump to create a transmembrane electrochemical gradient." [GOC:curators, GOC:ecd, ISBN:0198547684] synonym: "mitochondrial electron transport chain" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0070469 ! respiratory chain relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005747 name: mitochondrial respiratory chain complex I namespace: cellular_component alt_id: GO:0005748 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. It contains about 25 different polypeptide subunits, including NADH dehydrogenase (ubiquinone), flavin mononucleotide and several different iron-sulfur clusters containing non-heme iron. The iron undergoes oxidation-reduction between Fe(II) and Fe(III), and catalyzes proton translocation linked to the oxidation of NADH by ubiquinone." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045271 ! respiratory chain complex I intersection_of: GO:0045271 ! respiratory chain complex I intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005749 name: mitochondrial respiratory chain complex II namespace: cellular_component alt_id: GO:0008136 alt_id: GO:0009362 alt_id: GO:0019738 alt_id: GO:0030390 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the four polypeptide subunits of succinate dehydrogenase, flavin-adenine dinucleotide and iron-sulfur. Catalyzes the oxidation of succinate by ubiquinone. Connects the TCA cycle with the respiratory chain." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial fumarate reductase complex" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045257 ! succinate dehydrogenase complex (ubiquinone) is_a: GO:0045283 ! fumarate reductase complex intersection_of: GO:0045283 ! fumarate reductase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005750 name: mitochondrial respiratory chain complex III namespace: cellular_component alt_id: GO:0015008 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains about 10 polypeptide subunits including four redox centers: cytochrome b/b6, cytochrome c1 and an 2Fe-2S cluster. Catalyzes the oxidation of ubiquinol by oxidized cytochrome c1." [GOC:mtg_sensu, ISBN:0198547684] synonym: "mitochondrial complex III" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc(1) complex" EXACT [GOC:mcc] synonym: "mitochondrial cytochrome bc1 complex" EXACT [GOC:mcc] synonym: "mitochondrial electron transport complex III" RELATED [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome c oxidoreductase complex" EXACT [GOC:mcc] synonym: "mitochondrial ubiquinol-cytochrome-c reductase complex" EXACT [GOC:mcc] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045275 ! respiratory chain complex III intersection_of: GO:0045275 ! respiratory chain complex III intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005751 name: mitochondrial respiratory chain complex IV namespace: cellular_component alt_id: GO:0005752 def: "A protein complex located in the mitochondrial inner membrane that forms part of the mitochondrial respiratory chain. Contains the 13 polypeptide subunits of cytochrome c oxidase, including cytochrome a and cytochrome a3. Catalyzes the oxidation of reduced cytochrome c by dioxygen (O2)." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045277 ! respiratory chain complex IV intersection_of: GO:0045277 ! respiratory chain complex IV intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005746 ! mitochondrial respiratory chain [Term] id: GO:0005753 name: mitochondrial proton-transporting ATP synthase complex namespace: cellular_component alt_id: GO:0016470 def: "A proton-transporting ATP synthase complex found in the mitochondrial membrane." [GOC:mah, GOC:mtg_sensu] synonym: "mitochondrial respiratory chain complex V" EXACT [] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045259 ! proton-transporting ATP synthase complex intersection_of: GO:0045259 ! proton-transporting ATP synthase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005743 ! mitochondrial inner membrane [Term] id: GO:0005754 name: mitochondrial proton-transporting ATP synthase, catalytic core namespace: cellular_component def: "The hexamer, comprising three alpha and three beta subunits, that possesses the catalytic activity of the mitochondrial hydrogen-transporting ATP synthase." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045267 ! proton-transporting ATP synthase, catalytic core intersection_of: GO:0045267 ! proton-transporting ATP synthase, catalytic core intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005755 name: hydrogen-transporting ATP synthase, coupling factor CF(0) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. is_obsolete: true consider: GO:0045263 [Term] id: GO:0005756 name: mitochondrial proton-transporting ATP synthase, central stalk namespace: cellular_component def: "One of two stalks that connect the catalytic core of the hydrogen-transporting ATP synthase to the mitochondrial membrane-associated F0 proteins; rotates within the catalytic core during catalysis." [GOC:mtg_sensu, PMID:10838056] is_a: GO:0044455 ! mitochondrial membrane part is_a: GO:0045269 ! proton-transporting ATP synthase, central stalk intersection_of: GO:0045269 ! proton-transporting ATP synthase, central stalk intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0000275 ! mitochondrial proton-transporting ATP synthase complex, catalytic core F(1) [Term] id: GO:0005757 name: mitochondrial permeability transition pore complex namespace: cellular_component def: "A protein complex that connects the inner and outer membranes of animal mitochondria and acts as a pore that can open transiently to allow free diffusion of solutes between the mitochondrial matrix and the cytosol." [PMID:10393078] synonym: "mitochondrial PT pore complex" EXACT [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0046930 ! pore complex relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005758 name: mitochondrial intermembrane space namespace: cellular_component alt_id: GO:0031971 def: "The region between the inner and outer lipid bilayers of the mitochondrial envelope." [GOC:mah] synonym: "mitochondrial envelope lumen" EXACT [] synonym: "mitochondrial membrane lumen" RELATED [] xref: NIF_Subcellular:sao118944228 is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005740 ! mitochondrial envelope [Term] id: GO:0005759 name: mitochondrial matrix namespace: cellular_component def: "The gel-like material, with considerable fine structure, that lies in the matrix space, or lumen, of a mitochondrion. It contains the enzymes of the tricarboxylic acid cycle and, in some organisms, the enzymes concerned with fatty acid oxidation." [GOC:as, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mitochondrial stroma" NARROW [] xref: NIF_Subcellular:sao1804523077 xref: Wikipedia:Mitochondrial_matrix is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0031980 ! mitochondrial lumen [Term] id: GO:0005760 name: gamma DNA polymerase complex namespace: cellular_component def: "A DNA polymerase complex consisting of a large subunit, responsible for the catalytic activities, and a small accessory subunit. Functions in the replication and repair of mitochondrial DNA." [GOC:jl, PMID:12045093] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044429 ! mitochondrial part relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005761 name: mitochondrial ribosome namespace: cellular_component def: "A ribosome found in the mitochondrion of a eukaryotic cell; contains a characteristic set of proteins distinct from those of cytosolic ribosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "55S ribosome, mitochondrial" NARROW [] is_a: GO:0000313 ! organellar ribosome is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005762 name: mitochondrial large ribosomal subunit namespace: cellular_component def: "The larger of the two subunits of a mitochondrial ribosome. Two sites on the ribosomal large subunit are involved in translation: the aminoacyl site (A site) and peptidyl site (P site)." [GOC:mcc] synonym: "39S ribosomal subunit, mitochondrial" NARROW [] is_a: GO:0000315 ! organellar large ribosomal subunit is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0015934 ! large ribosomal subunit intersection_of: part_of GO:0005761 ! mitochondrial ribosome relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005763 name: mitochondrial small ribosomal subunit namespace: cellular_component def: "The smaller of the two subunits of a mitochondrial ribosome." [GOC:mcc] synonym: "28S ribosomal subunit, mitochondrial" NARROW [] synonym: "mitochondrial ribosomal small subunit complex" EXACT [] synonym: "mitochondrial ribosomal SSU complex" EXACT [] is_a: GO:0000314 ! organellar small ribosomal subunit is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0015935 ! small ribosomal subunit intersection_of: part_of GO:0005761 ! mitochondrial ribosome relationship: part_of GO:0005761 ! mitochondrial ribosome [Term] id: GO:0005764 name: lysosome namespace: cellular_component def: "A small lytic vacuole that has cell cycle-independent morphology and is found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_plant xref: NIF_Subcellular:sao585356902 xref: Wikipedia:Lysosome is_a: GO:0000323 ! lytic vacuole [Term] id: GO:0005765 name: lysosomal membrane namespace: cellular_component def: "The lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm." [GOC:ai] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0005764 ! lysosome [Term] id: GO:0005766 name: primary lysosome namespace: cellular_component def: "A lysosome before it has fused with a vesicle or vacuole." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: NIF_Subcellular:sao1140587416 is_a: GO:0005764 ! lysosome [Term] id: GO:0005767 name: secondary lysosome namespace: cellular_component def: "Vacuole formed by the fusion of a lysosome with an organelle (autosome) or with a primary phagosome." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: NIF_Subcellular:sao1549842807 is_a: GO:0005764 ! lysosome [Term] id: GO:0005768 name: endosome namespace: cellular_component def: "A membrane-bounded organelle that carries materials newly ingested by endocytosis. It passes many of the materials to lysosomes for degradation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_pir subset: goslim_plant xref: NIF_Subcellular:sao1720343330 xref: Wikipedia:Endosome is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005769 name: early endosome namespace: cellular_component def: "Small irregularly shaped intracellular vesicles to which endocytosed molecules are initially delivered." [GOC:rb] is_a: GO:0005768 ! endosome [Term] id: GO:0005770 name: late endosome namespace: cellular_component def: "A prelysosomal endocytic organelle differentiated from early endosomes by lower lumenal pH and different protein composition. Late endosomes are more spherical than early endosomes and are mostly juxtanuclear, being concentrated near the microtubule organizing center." [PMID:11964142, PMID:2557062] synonym: "prevacuolar compartment" EXACT [] synonym: "PVC" BROAD [] is_a: GO:0005768 ! endosome [Term] id: GO:0005771 name: multivesicular body namespace: cellular_component def: "A type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm." [PMID:11566881] synonym: "multivesicular endosome" EXACT [PMID:12122203] synonym: "MVB" EXACT [] synonym: "MVE" EXACT [PMID:12122203] xref: NIF_Subcellular:sao2045955158 is_a: GO:0005770 ! late endosome [Term] id: GO:0005773 name: vacuole namespace: cellular_component def: "A closed structure, found only in eukaryotic cells, that is completely surrounded by unit membrane and contains liquid material. Cells contain one or several vacuoles, that may have different functions from each other. Vacuoles have a diverse array of functions. They can act as a storage organelle for nutrients or waste products, as a degradative compartment, as a cost-effective way of increasing cell size, and as a homeostatic regulator controlling both turgor pressure and pH of the cytosol." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "vacuolar carboxypeptidase Y" RELATED [] xref: Wikipedia:Vacuole is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005774 name: vacuolar membrane namespace: cellular_component def: "The lipid bilayer surrounding the vacuole and separating its contents from the cytoplasm of the cell." [GOC:ai] subset: gosubset_prok is_a: GO:0031090 ! organelle membrane is_a: GO:0044437 ! vacuolar part [Term] id: GO:0005775 name: vacuolar lumen namespace: cellular_component def: "The volume enclosed within the vacuolar membrane." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0044437 ! vacuolar part is_a: GO:0070013 ! intracellular organelle lumen intersection_of: GO:0031974 ! membrane-enclosed lumen intersection_of: part_of GO:0005773 ! vacuole [Term] id: GO:0005776 name: autophagic vacuole namespace: cellular_component def: "A double-membrane-bounded compartment in which endogenous cellular material is sequestered; known as autophagosome in yeast." [ISBN:0198547684, PMID:11099404] synonym: "autophagosome" EXACT [] is_a: GO:0005773 ! vacuole [Term] id: GO:0005777 name: peroxisome namespace: cellular_component alt_id: GO:0019818 def: "A small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules; contains some enzymes that produce and others that degrade hydrogen peroxide (H2O2)." [ISBN:0815316194] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast synonym: "peroxisome vesicle" BROAD [] xref: NIF_Subcellular:sao499555322 xref: Wikipedia:Peroxisome is_a: GO:0042579 ! microbody [Term] id: GO:0005778 name: peroxisomal membrane namespace: cellular_component def: "The lipid bilayer surrounding a peroxisome." [GOC:mah] synonym: "peroxisome membrane" EXACT [] is_a: GO:0031903 ! microbody membrane is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005779 name: integral to peroxisomal membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a peroxisomal membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:mah] is_a: GO:0031231 ! intrinsic to peroxisomal membrane is_a: GO:0031301 ! integral to organelle membrane [Term] id: GO:0005780 name: extrinsic to intraperoxisomal membrane namespace: cellular_component def: "Loosely bound to the intraperoxisomal surface of the peroxisomal membrane, but not integrated into the hydrophobic region." [GOC:mah] synonym: "intra-peroxisomal peripheral membrane" RELATED [] is_a: GO:0031312 ! extrinsic to organelle membrane is_a: GO:0044439 ! peroxisomal part relationship: part_of GO:0005778 ! peroxisomal membrane [Term] id: GO:0005781 name: peroxisome targeting signal receptor complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a single polypeptide rather than a complex; all known peroxisome targeting signal receptors are monomeric. is_obsolete: true consider: GO:0000268 consider: GO:0006625 consider: GO:0044439 [Term] id: GO:0005782 name: peroxisomal matrix namespace: cellular_component alt_id: GO:0031909 def: "The volume contained within the membranes of a peroxisome; in many cells the matrix contains a crystalloid core largely composed of urate oxidase." [GOC:curators, ISBN:0815316194] synonym: "peroxisomal lumen" EXACT [] is_a: GO:0031907 ! microbody lumen is_a: GO:0044439 ! peroxisomal part [Term] id: GO:0005783 name: endoplasmic reticulum namespace: cellular_component def: "The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "ER" EXACT [] xref: NIF_Subcellular:sao1036339110 xref: Wikipedia:Endoplasmic_reticulum is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005784 name: Sec61 translocon complex namespace: cellular_component def: "A translocon complex that contains a core heterotrimer of conserved alpha, beta and gamma subunits, and may contain additional proteins (translocon-associated proteins or TRAPs); in budding yeast the core proteins are Sec61p, Sbh1p, and Sss1p. The Sec61 translocon complex functions in cotranslational and posttranslational translocation events." [GOC:mah, PMID:18166647] subset: goslim_pir synonym: "Sec61p-Sbh1p-Sss1p complex" NARROW [GOC:mah] is_a: GO:0071256 ! translocon complex [Term] id: GO:0005785 name: signal recognition particle receptor complex namespace: cellular_component def: "A transmembrane heterodimeric protein located in the membrane of the rough endoplasmic reticulum. Both subunits contain GTPase domains with which signal recognition particle interacts. In the presence of GTP and SRP receptor, SRP is released from the ribosome-nascent chain complex." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "docking protein complex" RELATED [] synonym: "SR complex" EXACT [] is_a: GO:0043235 ! receptor complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0030867 ! rough endoplasmic reticulum membrane [Term] id: GO:0005786 name: signal recognition particle, endoplasmic reticulum targeting namespace: cellular_component alt_id: GO:0005855 def: "A ribonucleoprotein particle of 325 kDa composed of a 7S (300 nucleotide) RNA molecule and a complex of six different polypeptides. This binds both to the N-terminal signal peptide for proteins destined for the endoplasmic reticulum as they emerge from the large ribosomal subunit and also to the ribosome. This binding arrests further translation thereby preventing the proteins from being released into the cytosol. The SRP-ribosome complex then diffuses to the endoplasmic reticulum where it is bound to the signal recognition particle receptor, which allows resumption of protein synthesis and facilitates the passage of the growing polypeptide chain through the translocon. Through a process involving GTP hydrolysis, the SRP-SRP receptor complex dissociates and SRP returns to the cytosol. Of the six polypeptides of SRP the 54 kDa subunit (SRP54) is the central player. It contains an N-terminal GTPase domain and a C-terminal domain that binds directly to the signal peptide and the SRP RNA. Examples of this component are found in Mus musculus, Saccharomyces cerevisiae and Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "signal sequence receptor complex" EXACT [] synonym: "SRP" EXACT [] xref: Wikipedia:Signal_recognition_particle is_a: GO:0048500 ! signal recognition particle [Term] id: GO:0005787 name: signal peptidase complex namespace: cellular_component def: "A protein complex that is located in the endoplasmic reticulum membrane and cleaves the signal sequence from precursor proteins following their transport out of the cytoplasmic space." [GOC:sgd_curators, PMID:1846444, PMID:7615509] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0005788 name: endoplasmic reticulum lumen namespace: cellular_component alt_id: GO:0016022 def: "The volume enclosed by the membranes of the endoplasmic reticulum." [ISBN:0198547684] synonym: "cisternal lumen" EXACT [] synonym: "endoplasmic reticulum cisterna" EXACT [] synonym: "ER cisterna" EXACT [] synonym: "ER lumen" EXACT [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005789 name: endoplasmic reticulum membrane namespace: cellular_component def: "The lipid bilayer surrounding the endoplasmic reticulum." [GOC:mah] synonym: "ER membrane" EXACT [] is_a: GO:0031090 ! organelle membrane is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0042175 ! nuclear membrane-endoplasmic reticulum network [Term] id: GO:0005790 name: smooth endoplasmic reticulum namespace: cellular_component def: "The smooth endoplasmic reticulum (ER) has with no ribosomes attached to it. The smooth is the recipient of the proteins synthesized in the rough ER. Those proteins to be exported are passed to the Golgi complex, the resident proteins are returned to the rough ER and the lysosomal proteins after phosphorylation of their mannose residues are passed to the lysosomes. Glycosylation of the glycoproteins also continues. The smooth ER is the site of synthesis of lipids, including the phospholipids. The membranes of the smooth ER also contain enzymes that catalyze a series of reactions to detoxify both lipid-soluble drugs and harmful products of metabolism. Large quantities of certain compounds such as phenobarbital cause an increase in the amount of the smooth ER." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "SER" EXACT [] synonym: "smooth ER" EXACT [] xref: NIF_Subcellular:sao710427438 xref: Wikipedia:Endoplasmic_reticulum#Smooth_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum is_a: GO:0071212 ! subsynaptic reticulum [Term] id: GO:0005791 name: rough endoplasmic reticulum namespace: cellular_component def: "The rough (or granular) endoplasmic reticulum (ER) has ribosomes adhering to the outer surface; the ribosomes are the site of translation of the mRNA for those proteins which are either to be retained within the cisternae (ER-resident proteins), the proteins of the lysosomes, or the proteins destined for export from the cell. Glycoproteins undergo their initial glycosylation within the cisternae." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "RER" EXACT [] synonym: "rough ER" EXACT [] xref: NIF_Subcellular:sao1881364067 xref: Wikipedia:Endoplasmic_reticulum#Rough_endoplasmic_reticulum is_a: GO:0005783 ! endoplasmic reticulum is_a: GO:0071212 ! subsynaptic reticulum [Term] id: GO:0005792 name: microsome namespace: cellular_component def: "Any of the small, heterogeneous, artifactual, vesicular particles, 50-150 nm in diameter, that are formed when some eukaryotic cells are homogenized and that sediment on centrifugation at 100000 g." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that this term refers to disrupted cells, and does not necessarily correspond to any specific structure(s) in an intact cell. synonym: "microsomal membrane" RELATED [] xref: Wikipedia:Microsome is_a: GO:0042598 ! vesicular fraction [Term] id: GO:0005793 name: ER-Golgi intermediate compartment namespace: cellular_component def: "A complex system of membrane-bounded compartments located between endoplasmic reticulum (ER) and the Golgi complex, with a distinctive membrane protein composition; involved in ER-to-Golgi transport." [PMID:16723730] synonym: "endoplasmic reticulum-Golgi intermediate compartment" EXACT [] synonym: "ERGIC" EXACT [] synonym: "pre-Golgi intermediate compartment" EXACT [] synonym: "vesicular-tubular cluster" EXACT [Wikipedia:Vesicular-tubular_cluster] xref: Wikipedia:Vesicular-tubular_cluster is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005794 name: Golgi apparatus namespace: cellular_component def: "A compound membranous cytoplasmic organelle of eukaryotic cells, consisting of flattened, ribosome-free vesicles arranged in a more or less regular stack. The Golgi apparatus differs from the endoplasmic reticulum in often having slightly thicker membranes, appearing in sections as a characteristic shallow semicircle so that the convex side (cis or entry face) abuts the endoplasmic reticulum, secretory vesicles emerging from the concave side (trans or exit face). In vertebrate cells there is usually one such organelle, while in invertebrates and plants, where they are known usually as dictyosomes, there may be several scattered in the cytoplasm. The Golgi apparatus processes proteins produced on the ribosomes of the rough endoplasmic reticulum; such processing includes modification of the core oligosaccharides of glycoproteins, and the sorting and packaging of proteins for transport to a variety of cellular locations. Three different regions of the Golgi are now recognized both in terms of structure and function: cis, in the vicinity of the cis face, trans, in the vicinity of the trans face, and medial, lying between the cis and trans regions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that the Golgi apparatus can be located in various places in the cytoplasm. In plants and lower animal cells, the Golgi apparatus exists as many copies of discrete stacks dispersed throughout the cytoplasm, while the Golgi apparatus of interphase mammalian cells is a juxtanuclear, often pericentriolar reticulum, where the discrete Golgi stacks are stitched together to form a compact and interconnected ribbon, sometimes called the Golgi ribbon. subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast synonym: "Golgi" BROAD [] synonym: "Golgi complex" EXACT [] synonym: "Golgi ribbon" NARROW [] xref: NIF_Subcellular:sao451912436 xref: Wikipedia:Golgi_apparatus is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005795 name: Golgi stack namespace: cellular_component alt_id: GO:0016940 def: "The set of thin, flattened membrane-bounded compartments, called cisternae, that form the central portion of the Golgi complex. The stack usually comprises cis, medial, and trans cisternae; the cis- and trans-Golgi networks are not considered part of the stack." [GOC:mah, ISBN:0815316194] synonym: "dictyosome" NARROW [] synonym: "Golgi cisternae" EXACT [] is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005796 name: Golgi lumen namespace: cellular_component def: "The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks." [GOC:mah] is_a: GO:0044431 ! Golgi apparatus part is_a: GO:0070013 ! intracellular organelle lumen [Term] id: GO:0005797 name: Golgi medial cisterna namespace: cellular_component def: "The middle Golgi cisterna (or cisternae)." [ISBN:0815316194] is_a: GO:0031985 ! Golgi cisterna [Term] id: GO:0005798 name: Golgi-associated vesicle namespace: cellular_component def: "Any vesicle associated with the Golgi complex and involved in mediating transport within the Golgi or between the Golgi and other parts of the cell." [GOC:mah] comment: Note that this definition includes vesicles that are transiently associated with the Golgi. synonym: "Golgi vesicle" RELATED [] xref: NIF_Subcellular:sao819927218 is_a: GO:0016023 ! cytoplasmic membrane-bounded vesicle is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005799 name: coatomer namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its position and synonym implied that it confused a coated vesicle with the coat itself. synonym: "COPI vesicle" RELATED [] is_obsolete: true consider: GO:0030126 consider: GO:0030137 [Term] id: GO:0005800 name: COPII vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030134 [Term] id: GO:0005801 name: cis-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the convex side of the Golgi apparatus, which abuts the endoplasmic reticulum." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815316194] synonym: "cis Golgi network" EXACT [] synonym: "forming face" RELATED [] synonym: "Golgi cis face" RELATED [] synonym: "Golgi cis-face" RELATED [] is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005802 name: trans-Golgi network namespace: cellular_component def: "The network of interconnected tubular and cisternal structures located at the side of the Golgi apparatus distal to the endoplasmic reticulum, from which secretory vesicles emerge. The trans-Golgi network is important in the later stages of protein secretion where it is thought to play a key role in the sorting and targeting of secreted proteins to the correct destination." [GOC:vw, ISBN:0815316194] synonym: "Golgi trans face" RELATED [] synonym: "Golgi trans-face" RELATED [] synonym: "late Golgi" RELATED [GOC:mah] synonym: "maturing face" RELATED [] synonym: "TGN" EXACT [] synonym: "trans Golgi network" EXACT [] xref: NIF_Subcellular:sao9456487 is_a: GO:0044431 ! Golgi apparatus part [Term] id: GO:0005803 name: secretory vesicle namespace: cellular_component def: "OBSOLETE. A small subcellular vesicle, or granule, surrounded by a single-layered membrane; formed from the Golgi apparatus and contains a highly concentrated protein destined for secretion." [ISBN:0198547684] comment: This term was made obsolete because it was being used to describe two different components. synonym: "transition vesicle" NARROW [] is_obsolete: true consider: GO:0030133 consider: GO:0030141 [Term] id: GO:0005804 name: secretory vesicle membrane namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its parent was made obsolete. is_obsolete: true consider: GO:0030658 consider: GO:0030667 [Term] id: GO:0005805 name: ER-Golgi transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030134 [Term] id: GO:0005806 name: Golgi-ER transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030142 [Term] id: GO:0005808 name: Golgi-plasma membrane transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; a personal communication from John Armstrong indicated that a replacement term was not required, as TGN-Golgi transport is likely to be mediated by tubules rather than vesicles. is_obsolete: true consider: GO:0030133 [Term] id: GO:0005809 name: Golgi-vacuole transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true consider: GO:0030133 [Term] id: GO:0005810 name: endocytotic transport vesicle namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology suggested that a new term was required. is_obsolete: true replaced_by: GO:0030139 [Term] id: GO:0005811 name: lipid particle namespace: cellular_component def: "Any particle of coalesced lipids in the cytoplasm of a cell. May include associated proteins." [GOC:mah] comment: Note that this term does not refer to vesicles, but instead to structures in which lipids do not necessarily form bilayers. subset: goslim_generic synonym: "adiposome" EXACT [] synonym: "lipid body" EXACT [] synonym: "lipid droplet" EXACT [] is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005813 name: centrosome namespace: cellular_component def: "A structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle." [GOC:mah, ISBN:0198547684] subset: goslim_pir xref: Wikipedia:Centrosome is_a: GO:0005815 ! microtubule organizing center is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005814 name: centriole namespace: cellular_component def: "A cellular organelle, found close to the nucleus in many eukaryotic cells, consisting of a small cylinder with microtubular walls, 300-500 nm long and 150-250 nm in diameter. It contains nine short, parallel, peripheral microtubular fibrils, each fibril consisting of one complete microtubule fused to two incomplete microtubules. Cells usually have two centrioles, lying at right angles to each other. At division, each pair of centrioles generates another pair and the twin pairs form the pole of the mitotic spindle." [ISBN:0198547684] xref: NIF_Subcellular:sao95019936 xref: Wikipedia:Centriole is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0005815 name: microtubule organizing center namespace: cellular_component def: "A cytoplasmic structure that can catalyze gamma-tubulin-dependent microtubule nucleation and that can anchor microtubules by interacting with their minus ends, plus ends or sides." [ISBN:0815316194, PMID:17245416] subset: goslim_candida subset: goslim_generic subset: goslim_yeast synonym: "microtubule organising centre" EXACT [] synonym: "MTOC" EXACT [] xref: Wikipedia:Microtubule_organizing_center is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005816 name: spindle pole body namespace: cellular_component def: "The microtubule organizing center in fungi; functionally homologous to the animal cell centrosome." [ISBN:0879693568] xref: Wikipedia:Spindle_pole_body is_a: GO:0005815 ! microtubule organizing center relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005817 name: centrosomal mitotic factor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:clt] comment: This term was made obsolete because it was not defined. is_obsolete: true [Term] id: GO:0005818 name: aster namespace: cellular_component def: "An array of microtubules emanating from a spindle pole MTOC that do not connect to kinetochores." [GOC:clt] is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005819 name: spindle namespace: cellular_component def: "The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart." [ISBN:0198547684] xref: Wikipedia:Spindle_apparatus is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005821 name: intermediate layer of spindle pole body namespace: cellular_component def: "Structure between the central and outer plaques of the spindle pole body." [PMID:9215630] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005822 name: inner plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the inner plaque is in the nucleus." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005823 name: central plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the central plaque is embedded in the nuclear envelope." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005824 name: outer plaque of spindle pole body namespace: cellular_component def: "One of three laminate structures that form the spindle pole body; the outer plaque is in the cytoplasm." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005825 name: half bridge of spindle pole body namespace: cellular_component def: "Structure adjacent to the plaques of the spindle pole body." [ISBN:0879693568] is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005816 ! spindle pole body [Term] id: GO:0005826 name: actomyosin contractile ring namespace: cellular_component alt_id: GO:0030480 def: "A cytoskeletal structure composed of actin filaments and myosin that forms beneath the plasma membrane of many cells, including animal cells and yeast cells, in a plane perpendicular to the axis of the spindle, i.e. the cell division plane. Ring contraction is associated with centripetal growth of the membrane that divides the cytoplasm of the two daughter cells. In animal cells, the contractile ring is located inside the plasma membrane at the location of the cleavage furrow. In budding fungal cells, e.g. mitotic S. cerevisiae cells, the contractile ring forms beneath the plasma membrane at the mother-bud neck before mitosis." [GOC:expert_jrp, GOC:sgd_curators, ISBN:0805319409, ISBN:0815316194] synonym: "actomyosin ring" RELATED [] synonym: "CAR" EXACT [] synonym: "constriction ring" RELATED [] synonym: "contractile actomyosin ring" EXACT [] synonym: "cytokinetic ring" NARROW [] is_a: GO:0032155 ! cell division site part is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part is_a: GO:0070938 ! contractile ring relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005827 name: polar microtubule namespace: cellular_component def: "Any of the spindle microtubules that come from each pole and overlap at the spindle midzone. This interdigitating structure consisting of antiparallel microtubules is responsible for pushing the poles of the spindle apart." [ISBN:0815316194] synonym: "pole-to-pole microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule intersection_of: GO:0005876 ! spindle microtubule intersection_of: part_of GO:0000922 ! spindle pole relationship: part_of GO:0000922 ! spindle pole [Term] id: GO:0005828 name: kinetochore microtubule namespace: cellular_component def: "Any of the spindle microtubules that attach to the kinetochores of chromosomes by their plus ends, and maneuver the chromosomes during mitotic or meiotic chromosome segregation." [ISBN:0815316194] synonym: "pole-to-kinetochore microtubule" EXACT [] is_a: GO:0005876 ! spindle microtubule [Term] id: GO:0005829 name: cytosol namespace: cellular_component def: "The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes." [GOC:hgd, GOC:jl] subset: goslim_generic subset: goslim_plant subset: gosubset_prok xref: NIF_Subcellular:sao101633890 xref: Wikipedia:Cytosol is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005831 name: steroid hormone aporeceptor complex namespace: cellular_component def: "A protein complex consisting of a steroid receptor associated with nonreceptor proteins, minimally a dimer of Hsp90 and a monomer of hsp56/FKBP59; forms in the absence of bound ligand." [PMID:7493981] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005832 name: chaperonin-containing T-complex namespace: cellular_component def: "A multisubunit ring-shaped complex that mediates protein folding in the cytosol without a cofactor." [GOC:sgd_curators, PMID:11580267] synonym: "CCT particle" EXACT [] synonym: "TriC" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005833 name: hemoglobin complex namespace: cellular_component def: "An iron-containing, oxygen carrying complex. In vertebrates it is made up of two pairs of associated globin polypeptide chains, each chain carrying a noncovalently bound heme prosthetic group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "haemoglobin complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005834 name: heterotrimeric G-protein complex namespace: cellular_component def: "Any of a family of heterotrimeric GTP-binding and hydrolyzing proteins; they belong to a superfamily of GTPases that includes monomeric proteins such as EF-Tu and RAS. Heterotrimeric G-proteins consist of three subunits; the alpha subunit contains the guanine nucleotide binding site and possesses GTPase activity; the beta and gamma subunits are tightly associated and function as a beta-gamma heterodimer; extrinsic plasma membrane proteins (cytoplasmic face) that function as a complex to transduce signals from G-protein coupled receptors to an effector protein." [ISBN:0198547684] comment: See also the molecular function term 'G-protein coupled receptor activity ; GO:0004930'. subset: gosubset_prok synonym: "heterotrimeric G-protein GTPase activity" RELATED [] synonym: "heterotrimeric G-protein GTPase, alpha-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, beta-subunit" NARROW [] synonym: "heterotrimeric G-protein GTPase, gamma-subunit" NARROW [] is_a: GO:0019897 ! extrinsic to plasma membrane is_a: GO:0043234 ! protein complex [Term] id: GO:0005835 name: fatty acid synthase complex namespace: cellular_component alt_id: GO:0031373 alt_id: GO:0031374 def: "A multienzyme complex that catalyses the synthesis of fatty acids from acetyl CoA." [GOC:pd, GOC:sgd_curators, ISBN:0716746840] subset: goslim_pir subset: gosubset_prok synonym: "cytosolic FAS complex" EXACT [] synonym: "cytosolic fatty acid synthase complex" EXACT [] synonym: "cytosolic type I FAS complex" EXACT [] synonym: "cytosolic type I fatty acid synthase complex" EXACT [] synonym: "FAS complex" EXACT [] synonym: "fatty acid synthetase complex" EXACT [] synonym: "holo-[acyl-carrier-protein] synthase complex" RELATED [] xref: Wikipedia:Fatty_acid_synthetase_complex is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005836 name: fatty-acyl-CoA synthase complex namespace: cellular_component def: "A protein complex that possesses fatty-acyl-CoA synthase activity." [BRENDA:2.3.1.86, GOC:mah] comment: Note that fatty acid synthetases of vertebrates and yeast are stable enzyme complexes of multifunctional polypeptide chains, whereas the fatty acid synthetases of plants and E. coli consist of non-associated individual enzymes. is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005837 name: 26S proteasome namespace: cellular_component def: "OBSOLETE. A large multisubunit protease found in the cytosol that recognizes, unfolds, and digests protein substrates that have been marked for degradation by the attachment of a ubiquitin moiety. Individual subcomplexes of the complete 26S proteasome are involved in these different tasks: the ATP-dependent 19S caps are believed to unfold substrates and feed them to the actual protease, the 20S proteasome." [PMID:10410804] comment: This term was made obsolete because its definition was inaccurate. is_obsolete: true consider: GO:0000502 [Term] id: GO:0005838 name: proteasome regulatory particle namespace: cellular_component def: "A multisubunit complex, which caps one or both ends of the proteasome core complex. This complex recognizes and unfolds ubiquitinated proteins, and translocates them to the proteasome core complex." [GOC:mtg_sensu, GOC:rb] synonym: "19S regulatory particle" NARROW [] synonym: "modulator complex" RELATED [CORUM:28] synonym: "PA700 proteasome activator" NARROW [] synonym: "PA700-dependent proteasome activator" EXACT [CORUM:28] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0005839 name: proteasome core complex namespace: cellular_component alt_id: GO:0000503 def: "A multisubunit barrel shaped endoprotease complex, which is the core of the proteasome complex." [GOC:rb, PMID:10806206] synonym: "20S core complex" NARROW [] synonym: "20S proteasome" NARROW [GOC:cjk] synonym: "macropain" EXACT [] synonym: "PA28gamma-20S proteasome" NARROW [CORUM:194] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0000502 ! proteasome complex [Term] id: GO:0005840 name: ribosome namespace: cellular_component def: "An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "ribosomal RNA" RELATED [] xref: NIF_Subcellular:sao1429207766 xref: Wikipedia:Ribosome is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0043232 ! intracellular non-membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005844 name: polysome namespace: cellular_component def: "Several ribosomes bound to one mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir synonym: "polyribosome" EXACT [] xref: Wikipedia:Polysome is_a: GO:0030529 ! ribonucleoprotein complex [Term] id: GO:0005845 name: mRNA cap binding complex namespace: cellular_component def: "Any protein complex that binds to an mRNA cap at any time in the lifetime of the mRNA." [GOC:jid] synonym: "mRNA cap complex" RELATED [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005846 name: nuclear cap binding complex namespace: cellular_component def: "A conserved heterodimeric protein complex that binds to the 5' terminal cap structure m7G(5')ppp(5')N of nascent eukaryotic RNA polymerase II transcripts such as pre-mRNA and U snRNA. The consists of proteins known as CBP20 and CBP80, binds to cap structures in the nucleus, and is involved in pre-mRNA splicing, 3'-end formation, and RNA nuclear export." [PMID:16043498] comment: Note that this complex can be found in the cytoplasm as well as the nucleus. synonym: "CBC" RELATED [] synonym: "mRNA cap binding complex" NARROW [] synonym: "NCBP-NIP1 complex" NARROW [] synonym: "snRNA cap binding complex" NARROW [] is_a: GO:0034518 ! RNA cap binding complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005847 name: mRNA cleavage and polyadenylation specificity factor complex namespace: cellular_component def: "A multisubunit complex that binds to the canonical AAUAAA hexamer and to U-rich upstream sequence elements on the pre-mRNA, thereby stimulating the otherwise weakly active and nonspecific polymerase to elongate efficiently RNAs containing a poly(A) signal." [PMID:14749727] synonym: "CFII complex" RELATED [] synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "CPF complex" NARROW [] synonym: "CPSF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005848 name: mRNA cleavage stimulating factor complex namespace: cellular_component def: "A protein complex required for mRNA cleavage but not for poly(A) addition." [GOC:mah, PMID:10357856] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "CstF complex" NARROW [] is_a: GO:0005849 ! mRNA cleavage factor complex [Term] id: GO:0005849 name: mRNA cleavage factor complex namespace: cellular_component def: "Any macromolecular complex involved in cleavage or polyadenylation of mRNA molecules." [GOC:mah, PMID:10357856] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0005850 name: eukaryotic translation initiation factor 2 complex namespace: cellular_component def: "Complex of three heterogeneous polypeptide chains, that form a ternary complex with initiator methionyl-tRNA and GTP. This ternary complex binds to free 40S subunit, which subsequently binds the 5' end of mRNA." [PMID:10216940] synonym: "eIF-2" EXACT [] synonym: "eIF2" EXACT [GOC:mah] xref: Wikipedia:EIF-2 is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005851 name: eukaryotic translation initiation factor 2B complex namespace: cellular_component def: "A multisubunit guanine nucleotide exchange factor which catalyzes the exchange of GDP bound to initiation factor eIF2 for GTP, generating active eIF2-GTP. In humans, it is composed of five subunits, alpha, beta, delta, gamma and epsilon." [PMID:9438375] synonym: "eIF-2B" EXACT [] synonym: "eif2B" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005852 name: eukaryotic translation initiation factor 3 complex namespace: cellular_component def: "A complex of several polypeptides that plays at least two important roles in protein synthesis: First, eIF3 binds to the 40S ribosome and facilitates loading of the Met-tRNA/eIF2.GTP ternary complex to form the 43S preinitiation complex. Subsequently, eIF3 apparently assists eIF4 in recruiting mRNAs to the 43S complex. The eIF3 complex contains five conserved core subunits, and may contain several additional proteins; the non-core subunits are thought to mediate association of the complex with specific sets of mRNAs." [PMID:15904532] synonym: "eIF-3" EXACT [] synonym: "eIF3" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005853 name: eukaryotic translation elongation factor 1 complex namespace: cellular_component def: "A multisubunit nucleotide exchange complex that binds GTP and aminoacyl-tRNAs, and catalyzes their codon-dependent placement at the A-site of the ribosome. In humans, the complex is composed of four subunits, alpha, beta, delta and gamma." [GOC:jl, PMID:10216950] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005854 name: nascent polypeptide-associated complex namespace: cellular_component def: "A heterodimeric protein complex that can reversibly bind to ribosomes, and is located in direct proximity to newly synthesized polypeptide chains as they emerge from the ribosome." [PMID:12475173, PMID:7568149] synonym: "NAC" EXACT [] synonym: "NACA" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005856 name: cytoskeleton namespace: cellular_component def: "Any of the various filamentous elements that form the internal framework of cells, and typically remain after treatment of the cells with mild detergent to remove membrane constituents and soluble components of the cytoplasm. The term embraces intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles." [GOC:mah, ISBN:0198547684, PMID:16959967] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok xref: Wikipedia:Cytoskeleton is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0005858 name: axonemal dynein complex namespace: cellular_component def: "A dynein complex found in eukaryotic cilia and flagella; the motor domain heads interact with adjacent microtubules to generate a sliding force which is converted to a bending motion. May contain two or three dynein heavy chains as well as several light chains." [ISBN:0815316194] synonym: "axonemal dynein heavy chain" NARROW [] synonym: "axonemal dynein intermediate chain" NARROW [] synonym: "axonemal dynein intermediate light chain" NARROW [] synonym: "axonemal dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex is_a: GO:0044447 ! axoneme part intersection_of: GO:0030286 ! dynein complex intersection_of: part_of GO:0005930 ! axoneme [Term] id: GO:0005859 name: muscle myosin complex namespace: cellular_component def: "A filament of myosin found in a muscle cell of any type." [GOC:mah] is_a: GO:0016460 ! myosin II complex is_a: GO:0044449 ! contractile fiber part intersection_of: GO:0016460 ! myosin II complex intersection_of: part_of GO:0043292 ! contractile fiber [Term] id: GO:0005861 name: troponin complex namespace: cellular_component def: "A complex of accessory proteins (typically troponin T, troponin I and troponin C) found associated with actin in muscle thin filaments; involved in calcium regulation of muscle contraction." [ISBN:0815316194] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005862 name: muscle thin filament tropomyosin namespace: cellular_component def: "A form of the tropomyosin dimer found associated with actin and the troponin complex in muscle thin filaments." [ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0005865 ! striated muscle thin filament [Term] id: GO:0005863 name: striated myosin muscle thick filament namespace: cellular_component def: "Bipolar filaments formed of polymers of a muscle-specific myosin II isoform, found in the middle of sarcomeres in myofibrils." [GOC:mtg_muscle, ISBN:0815316194] is_a: GO:0005859 ! muscle myosin complex is_a: GO:0032982 ! myosin filament relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005865 name: striated muscle thin filament namespace: cellular_component def: "Filaments formed of actin and associated proteins; attached to Z discs at either end of sarcomeres in myofibrils." [ISBN:0815316194] is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044449 ! contractile fiber part relationship: part_of GO:0015629 ! actin cytoskeleton relationship: part_of GO:0030017 ! sarcomere [Term] id: GO:0005868 name: cytoplasmic dynein complex namespace: cellular_component def: "Any dynein complex that catalyzes movement along a cytoplasmic microtubule; cytoplasmic dynein complexes participates in many transport activities in eukaryotes, such as mRNA localization, intermediate filament transport, nuclear envelope breakdown, apoptosis, transport of centrosomal proteins, mitotic spindle assembly, virus transport, kinetochore functions, and movement of signaling and spindle checkpoint proteins. Subunits associated with the dynein heavy chain mediate association between dynein heavy chain and cargoes,and may include light chains and light intermediate chains." [GOC:mah, PMID:12600311] synonym: "cytoplasmic dynein heavy chain" NARROW [] synonym: "cytoplasmic dynein intermediate chain" NARROW [] synonym: "cytoplasmic dynein intermediate light chain" NARROW [] synonym: "cytoplasmic dynein light chain" NARROW [] is_a: GO:0030286 ! dynein complex is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0030286 ! dynein complex intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005869 name: dynactin complex namespace: cellular_component def: "A 20S multiprotein assembly of total mass about 1.2 MDa that activates dynein-based activity in vivo. A large structural component of the complex is an actin-like 40 nm filament composed of actin-related protein, to which other components attach." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005875 ! microtubule associated complex relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005870 name: actin capping protein of dynactin complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, nucleates the polymerization of actin monomers but does not sever actin filaments, and which is a part of the dynactin complex." [GOC:jl, PMID:18221362, PMID:18544499] is_a: GO:0008290 ! F-actin capping protein complex intersection_of: GO:0008290 ! F-actin capping protein complex intersection_of: part_of GO:0005869 ! dynactin complex relationship: part_of GO:0005869 ! dynactin complex [Term] id: GO:0005871 name: kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work." [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html] is_a: GO:0005875 ! microtubule associated complex [Term] id: GO:0005872 name: minus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the minus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005873 name: plus-end kinesin complex namespace: cellular_component def: "Any complex that includes a dimer of molecules from the kinesin superfamily and any associated proteins, and moves towards the plus end of a microtubule." [GOC:mah] is_a: GO:0005871 ! kinesin complex [Term] id: GO:0005874 name: microtubule namespace: cellular_component def: "Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle." [ISBN:0879693568] xref: NIF_Subcellular:sao1846835077 xref: Wikipedia:Microtubule is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005875 name: microtubule associated complex namespace: cellular_component def: "Any multimeric complex connected to a microtubule." [GOC:jl] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0005876 name: spindle microtubule namespace: cellular_component def: "Any microtubule that is part of a mitotic or meiotic spindle; anchored at one spindle pole." [ISBN:0815316194] is_a: GO:0005874 ! microtubule intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005819 ! spindle relationship: part_of GO:0005819 ! spindle [Term] id: GO:0005879 name: axonemal microtubule namespace: cellular_component def: "A microtubule in the axoneme of a cilium or flagellum; an axoneme contains nine modified doublet microtubules surrounding a pair of single microtubules." [ISBN:0815316194] is_a: GO:0005874 ! microtubule is_a: GO:0044447 ! axoneme part intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005930 ! axoneme [Term] id: GO:0005880 name: nuclear microtubule namespace: cellular_component def: "Any microtubule in the nucleus of a cell." [GOC:mah] is_a: GO:0005874 ! microtubule is_a: GO:0044428 ! nuclear part intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005634 ! nucleus [Term] id: GO:0005881 name: cytoplasmic microtubule namespace: cellular_component def: "Any microtubule in the cytoplasm of a cell." [GOC:mah] synonym: "non-spindle-associated astral microtubule" NARROW [] is_a: GO:0005874 ! microtubule is_a: GO:0044444 ! cytoplasmic part intersection_of: GO:0005874 ! microtubule intersection_of: part_of GO:0005737 ! cytoplasm [Term] id: GO:0005882 name: intermediate filament namespace: cellular_component def: "A cytoskeletal structure that forms a distinct elongated structure, characteristically 10 nm in diameter, that occurs in the cytoplasm of eukaryotic cells. Intermediate filaments form a fibrous system, composed of chemically heterogeneous subunits and involved in mechanically integrating the various components of the cytoplasmic space. Intermediate filaments may be divided into five chemically distinct classes: Type I, acidic keratins; Type II, basic keratins; Type III, including desmin, vimentin and others; Type IV, neurofilaments and related filaments; and Type V, lamins." [http://www.cytochemistry.net/Cell-biology/intermediate_filaments.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "intermediate filament associated protein" RELATED [] synonym: "type I intermediate filament associated protein" RELATED [] synonym: "type II intermediate filament associated protein" RELATED [] xref: NIF_Subcellular:sao952483289 xref: Wikipedia:Intermediate_filament is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0045111 ! intermediate filament cytoskeleton [Term] id: GO:0005883 name: neurofilament namespace: cellular_component def: "A type of intermediate filament found in the core of neuronal axons. Neurofilaments are heteropolymers composed of three type IV polypeptides: NF-L, NF-M, and NF-H (for low, middle, and high molecular weight). Neurofilaments are responsible for the radial growth of an axon and determine axonal diameter." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363, ISBN:0815316194] synonym: "type IV intermediate filament" EXACT [] xref: NIF_Subcellular:sao1316272517 xref: Wikipedia:Neurofilament is_a: GO:0005882 ! intermediate filament is_a: GO:0033267 ! axon part intersection_of: GO:0005882 ! intermediate filament intersection_of: part_of GO:0030424 ! axon relationship: part_of GO:0060053 ! neurofilament cytoskeleton [Term] id: GO:0005884 name: actin filament namespace: cellular_component def: "A filamentous structure formed of a two-stranded helical polymer of the protein actin and associated proteins. Actin filaments are a major component of the contractile apparatus of skeletal muscle and the microfilaments of the cytoskeleton of eukaryotic cells. The filaments, comprising polymerized globular actin molecules, appear as flexible structures with a diameter of 5-9 nm. They are organized into a variety of linear bundles, two-dimensional networks, and three dimensional gels. In the cytoskeleton they are most highly concentrated in the cortex of the cell just beneath the plasma membrane." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10666339] synonym: "microfilament" EXACT [] xref: NIF_Subcellular:sao1588493326 xref: Wikipedia:Actin is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005885 name: Arp2/3 protein complex namespace: cellular_component def: "A stable protein complex that contains two actin-related proteins, Arp2 and Arp3, and five novel proteins (ARPC1-5), and functions in the nucleation of branched actin filaments." [GOC:jl, GOC:vw, PMID:12479800] is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0005886 name: plasma membrane namespace: cellular_component alt_id: GO:0005904 def: "The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins." [ISBN:0716731363] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "bacterial inner membrane" NARROW [] synonym: "cell membrane" EXACT [] synonym: "cytoplasmic membrane" EXACT [] synonym: "inner endospore membrane" NARROW [] synonym: "juxtamembrane" BROAD [] synonym: "plasma membrane lipid bilayer" NARROW [GOC:mah] synonym: "plasmalemma" EXACT [] xref: NIF_Subcellular:sao1663586795 xref: Wikipedia:Cell_membrane is_a: GO:0016020 ! membrane [Term] id: GO:0005887 name: integral to plasma membrane namespace: cellular_component def: "Penetrating at least one phospholipid bilayer of a plasma membrane. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] subset: gosubset_prok is_a: GO:0016021 ! integral to membrane is_a: GO:0031226 ! intrinsic to plasma membrane [Term] id: GO:0005888 name: proteoglycan integral to plasma membrane namespace: cellular_component def: "OBSOLETE. Penetrating at least one phospholipid bilayer of a plasma membrane and consisting of proteoglycan. Also refers to the state of being buried in the bilayer with no exposure outside the bilayer." [GOC:go_curators] comment: This term was made obsolete because it describes the composition (i.e. proteoglycan) and not the location of a gene product. is_obsolete: true replaced_by: GO:0005887 [Term] id: GO:0005889 name: hydrogen:potassium-exchanging ATPase complex namespace: cellular_component def: "A protein complex that possesses hydrogen:potassium-exchanging ATPase activity; characterized in animal cells, where it maintains ionic gradients of Na+ and K+ at the expense of ATP hydrolysis; The complex contains two obligatory subunits, the catalytic alpha subunit and a glycosylated beta subunit; two additional subunits, gamma and channel-inducing factor (CHIF), may also be present." [PMID:11756431] synonym: "hydrogen/potassium-exchanging ATPase complex" EXACT [] synonym: "proton pump" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005890 name: sodium:potassium-exchanging ATPase complex namespace: cellular_component def: "Sodium:potassium-exchanging ATPases are tetrameric proteins, consisting of two large alpha subunits and two smaller beta subunits. The alpha subunits bear the active site and penetrate the membrane, while the beta subunits carry oligosaccharide groups and face the cell exterior." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sodium pump" BROAD [] synonym: "sodium/potassium-exchanging ATPase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005891 name: voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential." [GOC:mah] subset: goslim_pir synonym: "voltage gated calcium channel complex" EXACT [] synonym: "voltage-dependent calcium channel complex" EXACT [] synonym: "voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0034704 ! calcium channel complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0005892 name: nicotinic acetylcholine-gated receptor-channel complex namespace: cellular_component def: "A protein complex that acts as an acetylcholine receptor, and forms a transmembrane channel through which ions may pass in response to ligand binding. The complex is a homo- or heteropentamer of subunits that are members of a neurotransmitter receptor superfamily." [GOC:mah, PMID:12381728, PMID:15579462] synonym: "nicotinic acetylcholine receptor" BROAD [] is_a: GO:0034702 ! ion channel complex is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005893 name: interleukin-2 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-2; comprises alpha, beta, and gamma subunits." [GOC:mah, PMID:3116143, PMID:8266078] synonym: "IL-2 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005894 name: interleukin-3 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-3 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-5." [PMID:11839579] synonym: "IL-3 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005895 name: interleukin-5 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-3; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-5 receptor, whereas the beta chain is shared with the receptors for granulocyte-macrophage colony-stimulating factor and interleukin-3." [GOC:mah, PMID:11312115, PMID:11839579] synonym: "IL-5 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005896 name: interleukin-6 receptor complex namespace: cellular_component def: "A hexameric protein complex consisting of two molecules each of interleukin-6, interleukin-6 receptor alpha chain, and gp-130." [PMID:8083235] synonym: "IL-6 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005897 name: interleukin-9 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-9; comprises an alpha and a beta subunit. The alpha chain is specific to the interleukin-9 receptor, whereas the beta chain is shared with the receptors for several other interleukins." [GOC:mah, PMID:10642536] synonym: "IL-9 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005898 name: interleukin-13 receptor complex namespace: cellular_component def: "A protein complex that binds interleukin-13; consists of two chains, interleukin-13 receptor alpha1 chain and interleukin-4 receptor alpha chain." [PMID:8552669, PMID:9013879] synonym: "IL-13 receptor complex" EXACT [GOC:add] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005899 name: insulin receptor complex namespace: cellular_component def: "A disulfide-bonded, heterotetrameric receptor complex. The alpha chains are entirely extracellular, while each beta chain has one transmembrane domain. The ligand binds to the alpha subunit extracellular domain and the kinase is associated with the beta subunit intracellular domain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005900 name: oncostatin-M receptor complex namespace: cellular_component def: "A heterodimeric receptor for the cytokine oncostatin-M (OSM). In humans the receptor complex is made up of the gene products gp130 and OSMR-beta." [GOC:jl, PMID:8999038] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0005901 name: caveola namespace: cellular_component alt_id: GO:0016599 def: "A membrane raft that forms small pit, depression, or invagination that communicates with the outside of a cell and extends inward, indenting the cytoplasm and the cell membrane. Examples include any of the minute pits or incuppings of the cell membrane formed during pinocytosis. Such caveolae may be pinched off to form free vesicles within the cytoplasm." [GOC:mah, http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "caveolae" EXACT [] synonym: "caveolar membrane" RELATED [] xref: Wikipedia:Caveolae is_a: GO:0044459 ! plasma membrane part is_a: GO:0045121 ! membrane raft [Term] id: GO:0005902 name: microvillus namespace: cellular_component def: "Thin cylindrical membrane-covered projections on the surface of an animal cell containing a core bundle of actin filaments. Present in especially large numbers on the absorptive surface of intestinal cells." [ISBN:0813516194] comment: Note that this term refers to a projection from a single cell, and should not be confused with 'microvillus' as used to refer to a multicellular structure such as that found in the placenta. subset: goslim_pir xref: Wikipedia:Microvillus is_a: GO:0042995 ! cell projection [Term] id: GO:0005903 name: brush border namespace: cellular_component def: "Dense covering of microvilli on the apical surface of epithelial cells in tissues such as the intestine, kidney, and choroid plexus; the microvilli aid absorption by increasing the surface area of the cell." [GOC:sl, ISBN:0815316194] subset: goslim_pir xref: Wikipedia:Brush_border is_a: GO:0042995 ! cell projection [Term] id: GO:0005905 name: coated pit namespace: cellular_component def: "A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:10559856, PMID:17284835] is_a: GO:0044425 ! membrane part relationship: part_of GO:0012505 ! endomembrane system [Term] id: GO:0005906 name: clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was positioned incorrectly, so the replacement term has a definition different from what this term appeared to mean. synonym: "adaptin" RELATED [] is_obsolete: true replaced_by: GO:0030119 [Term] id: GO:0005907 name: HA1 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP1" RELATED [] is_obsolete: true consider: GO:0030121 [Term] id: GO:0005908 name: HA2 clathrin adaptor namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete as part of a general reorganization of vesicle and vesicle coat terms; its position in the ontology was erroneous. synonym: "AP2" RELATED [] is_obsolete: true consider: GO:0030122 [Term] id: GO:0005911 name: cell-cell junction namespace: cellular_component def: "A cell junction that forms a connection between two cells; excludes direct cytoplasmic junctions such as ring canals." [GOC:dgh, GOC:hb, GOC:mah] synonym: "intercellular junction" EXACT [] xref: NIF_Subcellular:sao1922892319 is_a: GO:0030054 ! cell junction [Term] id: GO:0005912 name: adherens junction namespace: cellular_component def: "A cell junction at which anchoring proteins (cadherins or integrins) extend through the plasma membrane and are attached to actin filaments." [GOC:mah, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_a.html, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0070161 ! anchoring junction [Term] id: GO:0005913 name: cell-cell adherens junction namespace: cellular_component def: "An adherens junction which connects two cells to each other." [GOC:hb] is_a: GO:0005911 ! cell-cell junction is_a: GO:0005912 ! adherens junction [Term] id: GO:0005914 name: spot adherens junction namespace: cellular_component def: "A small junction assembled during the cellularization stage of insect embyrogenesis; spot adherens junctions later fuse to form the zonula adherens." [PMID:11700298] synonym: "dense plaque" BROAD [] synonym: "punctum adherens" EXACT [] is_a: GO:0005913 ! cell-cell adherens junction [Term] id: GO:0005915 name: zonula adherens namespace: cellular_component def: "A cell-cell adherens junction which forms a continuous belt near the apex of epithelial cells." [ISBN:0815316208] synonym: "adhesion belt" EXACT [] synonym: "belt desmosome" EXACT [] synonym: "fascia adhaerens" EXACT [] synonym: "intermediate junction" EXACT [] synonym: "zonula adhaerens" EXACT [] xref: NIF_Subcellular:sao1400623473 is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005916 name: fascia adherens namespace: cellular_component def: "A cell-cell junction that contains the transmembrane protein N-cadherin, which interacts with identical molecules from neighboring cells to form a tight mechanical intercellular link; forms a large portion of the intercalated disc, the structure at which myofibrils terminate in cardiomyocytes." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, PMID:11732910] xref: Wikipedia:Fascia_adherens is_a: GO:0005913 ! cell-cell adherens junction relationship: part_of GO:0014704 ! intercalated disc [Term] id: GO:0005917 name: nephrocyte junction namespace: cellular_component def: "A tissue-specific adherens junction found in kidney cells." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] is_a: GO:0005913 ! cell-cell adherens junction [Term] id: GO:0005918 name: septate junction namespace: cellular_component def: "A cell-cell junction that forms a continuous band around each cell in an epithelium; within the septate junction the membranes of adjacent cells maintain a constant distance of approximately 15 nm; found in invertebrates." [ISBN:0815332181, PMID:11700298] synonym: "septate desmosome" RELATED [] xref: NIF_Subcellular:sao427941916 is_a: GO:0070160 ! occluding junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005919 name: pleated septate junction namespace: cellular_component def: "A septate junction in which regular arrays of electron-dense septae span the intermembrane space." [PMID:11700298] synonym: "pleated desmosome" RELATED [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005920 name: smooth septate junction namespace: cellular_component def: "A septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions." [PMID:11700298] synonym: "zonula continua" EXACT [] is_a: GO:0005918 ! septate junction [Term] id: GO:0005921 name: gap junction namespace: cellular_component def: "A cell-cell junction that is composed of an array of small channels that permit small molecules to pass from one cell to another. At gap junctions, the membranes of two adjacent cells are separated by a uniform narrow gap of about 2-4 nm that is spanned by channel-forming proteins called connexins, which form hexagonal tubes called connexons." [GOC:mah, GOC:mtg_muscle, http://www.vivo.colostate.edu/hbooks/cmb/cells/pmemb/junctions_g.html, ISBN:0815332181] synonym: "communicating junction" EXACT [] synonym: "macula communicans" EXACT [] synonym: "zonula communicans" EXACT [] xref: NIF_Subcellular:sao118541872 xref: Wikipedia:Gap_junction is_a: GO:0005911 ! cell-cell junction [Term] id: GO:0005922 name: connexon complex namespace: cellular_component def: "An assembly of six molecules of connexin, made in the Golgi apparatus and subsequently transported to the plasma membrane, where docking of two connexons on apposed plasma membranes across the extracellular space forms a gap junction." [PMID:11146276] xref: NIF_Subcellular:sao445019788 is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005921 ! gap junction [Term] id: GO:0005923 name: tight junction namespace: cellular_component def: "An occluding cell-cell junction that is composed of a branching network of sealing strands that completely encircles the apical end of each cell in an epithelial sheet; the outer leaflets of the two interacting plasma membranes are seen to be tightly apposed where sealing strands are present. Each sealing strand is composed of a long row of transmembrane adhesion proteins embedded in each of the two interacting plasma membranes." [GOC:mah, ISBN:0815332181] synonym: "zonula occludens" EXACT [] xref: NIF_Subcellular:sao1939999134 xref: Wikipedia:Tight_junction is_a: GO:0070160 ! occluding junction relationship: part_of GO:0043296 ! apical junction complex [Term] id: GO:0005924 name: cell-substrate adherens junction namespace: cellular_component def: "An adherens junction which connects a cell to the extracellular matrix." [GOC:hb] synonym: "hemi-adherens junction" RELATED [] is_a: GO:0005912 ! adherens junction is_a: GO:0030055 ! cell-substrate junction [Term] id: GO:0005925 name: focal adhesion namespace: cellular_component alt_id: GO:0008357 def: "Small region on the surface of a cell that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments." [ISBN:0124325653, ISBN:0815316208] synonym: "focal contact" EXACT [] synonym: "hemi-adherens junction" RELATED [] xref: Wikipedia:Focal_adhesion is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005926 name: connecting hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction, also known as a hemiadherens junction (HAJ) that forms one of a pair of junctions in opposing cells that are separated by only 30-40nm, with a thin line of extracellular electron-dense material in between; found where muscles attach to epidermal cells directly (in insects)." [http://flybase.bio.indiana.edu/allied-data/lk/interactive-fly/aignfam/junction.htm] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005927 name: muscle tendon junction namespace: cellular_component def: "A cell-substrate junction found at the terminal anchorage site of skeletal muscle cells to tendons." [GOC:mtg_muscle, PMID:12842007] synonym: "myotendinous junction" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005928 name: apical hemi-adherens junction namespace: cellular_component def: "A cell-substrate adherens junction found in the apical region of a cell, such as those found in cuticle-secreting epithelia, which connect the apical membrane to the cuticle." [GOC:mah, PMID:11700298] synonym: "apical cell-substrate adherens junction" EXACT [GOC:mah] synonym: "apical dense plaque" EXACT [] is_a: GO:0005924 ! cell-substrate adherens junction [Term] id: GO:0005929 name: cilium namespace: cellular_component def: "A specialized eukaryotic organelle that consists of a filiform extrusion of the cell surface. Each cilium is bounded by an extrusion of the cytoplasmic membrane, and contains a regular longitudinal array of microtubules, anchored basally in a centriole." [GOC:kmv, ISBN:0198547684] subset: goslim_generic subset: goslim_pir xref: NIF_Subcellular:sao787716553 xref: Wikipedia:Cilium is_a: GO:0042995 ! cell projection [Term] id: GO:0005930 name: axoneme namespace: cellular_component def: "The bundle of microtubules and associated proteins that forms the core of cilia and flagella in eukaryotic cells and is responsible for their movements." [ISBN:0198547684] xref: Wikipedia:Axoneme is_a: GO:0044422 ! organelle part is_a: GO:0044424 ! intracellular part is_a: GO:0044463 ! cell projection part relationship: part_of GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0005931 name: nexin complex namespace: cellular_component def: "A protein complex found in the axoneme of eukaryotic cilia and flagella. It forms interconnections between the microtubule outer doublets that surround the inner central pair of microtubules." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043234 ! protein complex is_a: GO:0044447 ! axoneme part [Term] id: GO:0005932 name: microtubule basal body namespace: cellular_component def: "A short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium or flagellum that is similar in structure to a centriole. The basal body serves as a nucleation site for axoneme growth." [GOC:clt] xref: NIF_Subcellular:sao11978067 is_a: GO:0005815 ! microtubule organizing center is_a: GO:0044463 ! cell projection part intersection_of: GO:0005815 ! microtubule organizing center intersection_of: part_of GO:0042995 ! cell projection [Term] id: GO:0005933 name: cellular bud namespace: cellular_component def: "A protuberance from a cell of an organism that reproduces by budding, which will grow larger and become a separate daughter cell after nuclear division, cytokinesis, and cell wall formation (when appropriate). The daughter cell may completely separate from the mother cell, or the mother and daughter cells may remain associated." [GOC:sgd_curators] subset: goslim_candida subset: goslim_pir subset: goslim_yeast is_a: GO:0044464 ! cell part [Term] id: GO:0005934 name: cellular bud tip namespace: cellular_component def: "The end of a cellular bud distal to the site of attachment to the mother cell." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005935 name: cellular bud neck namespace: cellular_component def: "The constriction between the mother cell and daughter cell (bud) in an organism that reproduces by budding." [GOC:mah] is_a: GO:0030427 ! site of polarized growth relationship: part_of GO:0005933 ! cellular bud [Term] id: GO:0005936 name: shmoo namespace: cellular_component def: "OBSOLETE. The characteristic projection formed in response to mating pheromone by cells of Saccharomyces and other fungi with similar life cycles. Named after the Al Capp cartoon character, whose shape it resembles." [GOC:mah, GOC:mcc] comment: This term was made obsolete because it represents a type of whole cell rather than a cellular component. To update annotations, consider the external ontology term 'shmoo ; FAO:0001023'. is_obsolete: true consider: GO:0001400 consider: GO:0005937 [Term] id: GO:0005937 name: mating projection namespace: cellular_component def: "The projection formed by unicellular fungi in response to mating pheromone." [GOC:mcc] subset: goslim_pir synonym: "conjugation tube" NARROW [] synonym: "shmoo" NARROW [] is_a: GO:0042995 ! cell projection [Term] id: GO:0005938 name: cell cortex namespace: cellular_component def: "The region of a cell that lies just beneath the plasma membrane and often, but not always, contains a network of actin filaments and associated proteins." [GOC:mah, ISBN:0815316194] subset: goslim_candida subset: goslim_yeast synonym: "cell periphery" RELATED [] synonym: "peripheral cytoplasm" RELATED [] xref: Wikipedia:Cell_cortex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005940 name: septin ring namespace: cellular_component alt_id: GO:0030481 def: "A tight ring-shaped structure that forms in the division plane at the site of cytokinesis; composed of members of the conserved family of filament-forming proteins called septins as well as septin-associated proteins. This type of septin structure is observed at the bud neck of budding fungal cells, at the site of cell division in animal cells, at the junction between the mother cell and a pseudohyphal projection, and also within hyphae of filamentous fungi at sites where a septum will form." [GOC:krc, GOC:mah, PMID:16009555, PMID:16151244] xref: Wikipedia:Septin_ring is_a: GO:0032156 ! septin cytoskeleton is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part [Term] id: GO:0005941 name: unlocalized protein complex namespace: cellular_component def: "OBSOLETE. Used as a holding place for cellular components whose precise localization is, as yet, unknown, or has not been determined by GO (the latter is the major reason for nodes to have this parent); this term should not be used for annotation of gene products." [GOC:ma] comment: This term was made obsolete because it was originally intended only as a temporary parent for protein complex terms for which no more specific parents had been found. This term no longer has any children: All protein complex terms are is_a 'protein complex ; GO:0043234' and nearly all have been placed under parents to yield more specific paths traversing a part_of relationship. In other words, the term has been superseded by other terms and relationships in the cellular component ontology, and is no longer needed. is_obsolete: true [Term] id: GO:0005942 name: phosphoinositide 3-kinase complex namespace: cellular_component def: "A complex containing a heterodimer of a catalytic subunit and a regulatory (adaptor) subunit of any phosphoinositide 3-kinase (PI3K)." [GOC:bf] subset: goslim_pir synonym: "1-phosphatidylinositol 3-kinase complex" EXACT [] synonym: "phosphatidylinositol 3-kinase complex" EXACT [CORUM:429] synonym: "PI3-kinase p85-subunit alpha- PI3-kinase p110 complex" NARROW [CORUM:2575] synonym: "PI3K complex" EXACT [] synonym: "PIK3C3-PIK3R4 complex" NARROW [CORUM:429] synonym: "PIK3CA-PIK3R1 complex" NARROW [CORUM:439] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005943 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex namespace: cellular_component alt_id: GO:0035030 def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IA phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IA complex" EXACT [] synonym: "class IA PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IA" EXACT [] is_a: GO:0005942 ! phosphoinositide 3-kinase complex [Term] id: GO:0005944 name: 1-phosphatidylinositol-4-phosphate 3-kinase, class IB complex namespace: cellular_component alt_id: GO:0035031 def: "A heterodimeric protein complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic Class IB phosphoinositide 3-kinase (PI3K) subunit of 110-120 kDa and an associated regulatory subunit that is larger than, and unrelated to, the p85 proteins present in class IA complexes. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2] and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. Class IB PI3Ks are stimulated by G-proteins and do not interact with the SH2-domain containing adaptors that bind to Class IA PI3Ks." [PMID:9255069, PMID:9759495] synonym: "1-phosphatidylinositol-4-phosphate kinase, class IB complex" RELATED [] synonym: "class IB PI3K complex" EXACT [] synonym: "phosphoinositide 3-kinase complex, class IB" EXACT [] is_a: GO:0005942 ! phosphoinositide 3-kinase complex [Term] id: GO:0005945 name: 6-phosphofructokinase complex namespace: cellular_component def: "A protein complex that possesses 6-phosphofructokinase activity; homodimeric, homooctameric, and allosteric homotetrameric forms are known." [GOC:mah, GOC:vw, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0005946 name: alpha,alpha-trehalose-phosphate synthase complex (UDP-forming) namespace: cellular_component def: "A protein complex that possesses alpha,alpha-trehalose-phosphate synthase (UDP-forming) and trehalose-phosphatase activities, and thus catalyzes two reactions in trehalose biosynthesis. In the complex identified in Saccharomyces, Tps1p has alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity, Tps2p has trehalose 6-phosphate phosphatase activity; Tps3p is a regulatory subunit, and an additional subunit, Tsl1p, may be present." [PMID:9837904] comment: See also the molecular function term 'alpha,alpha-trehalose-phosphate synthase (UDP-forming) activity ; GO:0003825'. synonym: "trehalose-6-phosphate synthase complex" EXACT [] synonym: "trehalose-6-phosphate synthase/phosphatase" EXACT [] synonym: "UDP-glucose-glucosephosphate glucosyltransferase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005947 name: mitochondrial alpha-ketoglutarate dehydrogenase complex namespace: cellular_component def: "Mitochondrial complex that possesses alpha-ketoglutarate dehydrogenase activity." [GOC:mah, GOC:mtg_sensu] synonym: "2-oxoglutarate dehydrogenase complex" BROAD [] is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045240 ! dihydrolipoyl dehydrogenase complex intersection_of: GO:0045240 ! dihydrolipoyl dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005948 name: acetolactate synthase complex namespace: cellular_component def: "A dimeric (a large and a small chain) or tetrameric (two large and two small chains) enzyme complex. Catalyzes the formation of acetolactate from pyruvate." [BRENDA:2.2.1.6, GOC:jl, PMID:16458324, PMID:8756689] comment: See also the molecular function term 'acetolactate synthase activity ; GO:0003984'. subset: gosubset_prok synonym: "acetohydroxyacid synthase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005949 name: aminoadipate-semialdehyde dehydrogenase complex namespace: cellular_component def: "OBSOLETE. A heterodimeric enzyme composed of an alpha and beta subunit. Catalyzes the formation of L-2-aminoadipate from L-2-aminoadipate 6-semialdehyde." [EC:1.2.1.31] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide that is not part of a complex with other gene products. is_obsolete: true [Term] id: GO:0005950 name: anthranilate synthase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two components I and two components II. Catalyzes the formation of anthranilate, pyruvate and L-glutamate from chorismate and L-glutamine." [EC:4.1.3.27, MetaCyc:ANTHRANSYN-CPLX, PMID:4886290] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005951 name: carbamoyl-phosphate synthase complex namespace: cellular_component def: "A protein complex that catalyzes the formation of carbamoyl phosphate; comprises a small subunit that binds and cleaves glutamine, and a large subunit that accepts the ammonia moiety cleaved from glutamine, binds all of the remaining substrates and effectors, and carries out all of the other catalytic events." [PMID:8626695] comment: Note that in higher eukaryotes, carbamoyl-phosphate synthase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok synonym: "arginine-specific carbamoyl phosphate synthetase complex" NARROW [] synonym: "carbamoyl phosphate synthase complex" EXACT [] synonym: "carbamoyl-phosphate synthase arginine-specific complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005952 name: cAMP-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex, composed of regulatory and catalytic subunits, that catalyzes protein phosphorylation. Inactive forms of the enzyme have two regulatory chains and two catalytic chains; activation by cAMP produces two active catalytic monomers and a regulatory dimer." [EC:2.7.11.11, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase complex" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase complex" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase complex" EXACT [] synonym: "cyclic AMP-dependent protein kinase complex" EXACT [] synonym: "PKA" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005953 name: CAAX-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme, composed of an alpha and a beta subunit. Participates in the post-translational C-terminal modification of several small GTPases, allowing their targeting to the membrane." [PMID:9781874] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005954 name: calcium- and calmodulin-dependent protein kinase complex namespace: cellular_component def: "An enzyme complex which in eukaryotes is composed of four different chains: alpha, beta, gamma, and delta. The different isoforms assemble into homo- or heteromultimeric holoenzymes composed of 8 to 12 subunits. Catalyzes the phosphorylation of proteins to O-phosphoproteins." [EC:2.7.11.17] synonym: "calcium/calmodulin-dependent protein kinase complex" EXACT [] synonym: "CAMK2" EXACT [] synonym: "CaMKII" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005955 name: calcineurin complex namespace: cellular_component def: "A heterodimeric calcium ion and calmodulin dependent protein phosphatase composed of catalytic and regulatory subunits; the regulatory subunit is very similar in sequence to calmodulin." [ISBN:019859951] synonym: "calcium-dependent protein serine/threonine phosphatase complex" NARROW [] synonym: "protein phosphatase type 2B complex" EXACT [] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005956 name: protein kinase CK2 complex namespace: cellular_component def: "A protein complex that possesses protein serine/threonine kinase activity, and contains two catalytic alpha subunits and two regulatory beta subunits. Protein kinase CK2 complexes are found in nearly every subcellular compartment, and can phosphorylate many protein substrates in addition to casein." [GOC:mah, PMID:10994779] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. synonym: "casein kinase II complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005957 name: debranching enzyme namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is ambiguous (there are several debranching enzymes) and because it probably represents the glycogen debranching enzyme which is a single gene product and not a complex. is_obsolete: true consider: GO:0043033 [Term] id: GO:0005958 name: DNA-dependent protein kinase-DNA ligase 4 complex namespace: cellular_component alt_id: GO:0005959 def: "A large protein complex which is involved in the repair of DNA double-strand breaks and, in mammals, V(D)J recombination events. It consists of the DNA-dependent protein kinase catalytic subunit (DNA-PKcs), the DNA end-binding heterodimer Ku, the nuclear phosphoprotein XRCC4 or a homolog thereof, and DNA ligase IV." [GOC:jl, GOC:mah, PMID:10854421, PMID:12235392, PMID:17072889] is_a: GO:0044428 ! nuclear part is_a: GO:0070419 ! nonhomologous end joining complex [Term] id: GO:0005960 name: glycine cleavage complex namespace: cellular_component alt_id: GO:0005961 alt_id: GO:0070015 def: "A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T." [GOC:mah, MetaCyc:GCVMULTI-CPLX] subset: goslim_pir subset: gosubset_prok synonym: "glycine cleavage system" EXACT [] synonym: "glycine decarboxylase complex" EXACT [] synonym: "glycine dehydrogenase (decarboxylating) complex" EXACT [] synonym: "glycine dehydrogenase complex (decarboxylating)" RELATED [] synonym: "glycine synthase complex" EXACT [] xref: Wikipedia:Glycine_decarboxylase_complex is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005962 name: mitochondrial isocitrate dehydrogenase complex (NAD+) namespace: cellular_component def: "Mitochondrial complex that possesses isocitrate dehydrogenase (NAD+) activity." [GOC:mah, GOC:mtg_sensu] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The function of this complex is represented by the molecular function term 'isocitrate dehydrogenase (NAD+) activity ; GO:0004449'. is_a: GO:0030062 ! mitochondrial tricarboxylic acid cycle enzyme complex is_a: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) intersection_of: GO:0045242 ! isocitrate dehydrogenase complex (NAD+) intersection_of: part_of GO:0005739 ! mitochondrion [Term] id: GO:0005963 name: magnesium-dependent protein serine/threonine phosphatase complex namespace: cellular_component def: "An enzyme complex that catalyzes the removal of serine- or threonine-bound phosphate groups from a wide range of phosphoproteins, including a number of enzymes that have been phosphorylated under the action of a kinase." [EC:3.1.3.16] is_a: GO:0008287 ! protein serine/threonine phosphatase complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0005964 name: phosphorylase kinase complex namespace: cellular_component def: "An enzyme complex that catalyzes the phosphorylation of phosphorylase b to form phosphorylase a." [EC:2.7.11.19] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005965 name: protein farnesyltransferase complex namespace: cellular_component def: "A protein complex that possesses protein farnesyltransferase activity." [GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005966 name: cyclic-nucleotide phosphodiesterase complex namespace: cellular_component def: "An enzyme complex that catalyzes the hydrolysis of bonds in a cyclic nucleotide." [EC:3.1.4.-] synonym: "photoreceptor cyclic-nucleotide phosphodiesterase complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0005967 name: mitochondrial pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA in eukaryotes; includes subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). The This Eukaryotic form usually contains more subunits than its bacterial counterpart; for example, one known complex contains 30 E1 dimers, 60 E2 monomers, and 6 E3 dimers as well as a few copies of pyruvate dehydrogenase kinase and pyruvate dehydrogenase phosphatase." [GOC:mtg_sensu, ISBN:0471331309 "Biochemical Pathways", ISBN:0716720094] comment: Note that this term represents a location and not a function; the activity possessed by this complex is mentioned in the definition for the purpose of describing and distinguishing the complex. The functions of this complex are represented by the molecular function terms 'pyruvate dehydrogenase (lipoamide) activity ; GO:0004739', 'dihydrolipoamide S-acetyltransferase activity ; GO:0004742', and 'dihydrolipoamide dehydrogenase activity ; GO:0004148'. synonym: "pyruvate dehydrogenase complex (lipoamide)" BROAD [] is_a: GO:0044429 ! mitochondrial part is_a: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0005968 name: Rab-protein geranylgeranyltransferase complex namespace: cellular_component def: "A heterodimeric enzyme complex, which in mammals is composed of an alpha and a beta subunit, and which associates with an accessory protein Rep (Rab escort protein). Catalyzes of the transfer of a geranyl-geranyl moiety from geranylgeranyl pyrophosphate to a Rab protein." [GOC:jl, PMID:11886217] synonym: "GGTase-II complex" EXACT [] synonym: "Rab geranylgeranyltransferase complex" EXACT [] synonym: "RAB-protein geranylgeranyltransferase complex" EXACT [] synonym: "RabGGTase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005969 name: serine-pyruvate aminotransferase complex namespace: cellular_component alt_id: GO:0005970 def: "An enzyme complex that catalyzes the formation of hydroxypyruvate and alanine from serine and pyruvate." [EC:2.6.1.51] synonym: "serine-pyruvate aminotransferase, type 1 complex" NARROW [] synonym: "serine-pyruvate aminotransferase, type 2B complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005971 name: ribonucleoside-diphosphate reductase complex namespace: cellular_component def: "An enzyme complex composed of 2-4 or more subunits, which usually contains nonheme iron and requires ATP for catalysis. Catalyzes the formation of 2'-deoxyribonucleoside diphosphate and thioredoxin disulfide from ribonucleoside diphosphate and thioredoxin." [BRENDA:1.17.4.1] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0005972 name: fibrinogen alpha chain namespace: cellular_component alt_id: GO:0008005 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005973 name: fibrinogen beta chain namespace: cellular_component alt_id: GO:0008006 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005974 name: fibrinogen gamma chain namespace: cellular_component alt_id: GO:0008007 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true consider: GO:0005577 [Term] id: GO:0005975 name: carbohydrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. Includes the formation of carbohydrate derivatives by the addition of a carbohydrate residue to another molecule." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "carbohydrate metabolism" EXACT [] xref: Reactome:562514 "Metabolism of carbohydrates" xref: Reactome:588140 "Metabolism of carbohydrates" xref: Reactome:608908 "Metabolism of carbohydrates" xref: Reactome:633590 "Metabolism of carbohydrates" xref: Reactome:645266 "Metabolism of carbohydrates" xref: Reactome:655598 "Metabolism of carbohydrates" xref: Reactome:660921 "Metabolism of carbohydrates" xref: Reactome:666669 "Metabolism of carbohydrates" xref: Reactome:672761 "Metabolism of carbohydrates" xref: Reactome:678515 "Metabolism of carbohydrates" xref: Reactome:683472 "Metabolism of carbohydrates" xref: Reactome:689675 "Metabolism of carbohydrates" xref: Reactome:701412 "Metabolism of carbohydrates" xref: Reactome:71387 "Metabolism of carbohydrates" xref: Reactome:715983 "Metabolism of carbohydrates" xref: Reactome:720654 "Metabolism of carbohydrates" xref: Reactome:727930 "Metabolism of carbohydrates" xref: Reactome:730900 "Metabolism of carbohydrates" xref: Reactome:732992 "Metabolism of carbohydrates" xref: Reactome:733837 "Metabolism of carbohydrates" xref: Reactome:735540 "Metabolism of carbohydrates" xref: Reactome:736526 "Metabolism of carbohydrates" xref: Reactome:738451 "Metabolism of carbohydrates" xref: Wikipedia:Carbohydrate_metabolism is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0005976 name: polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polysaccharides, a polymer of more than 20 monosaccharide residues joined by glycosidic linkages." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok synonym: "glycan metabolic process" EXACT [] synonym: "glycan metabolism" EXACT [] synonym: "polysaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0005977 name: glycogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues in alpha(1->4) glycosidic linkage, joined together by alpha(1->6) glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen metabolism" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0006112 ! energy reserve metabolic process [Term] id: GO:0005978 name: glycogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen anabolism" EXACT [] synonym: "glycogen biosynthesis" EXACT [] synonym: "glycogen formation" EXACT [] synonym: "glycogen synthesis" EXACT [] xref: MetaCyc:GLYCOGENSYNTH-PWY xref: Reactome:562639 "Glycogen synthesis" xref: Reactome:588264 "Glycogen synthesis" xref: Reactome:609018 "Glycogen synthesis" xref: Reactome:633708 "Glycogen synthesis" xref: Reactome:645489 "Glycogen synthesis" xref: Reactome:655696 "Glycogen synthesis" xref: Reactome:661050 "Glycogen synthesis" xref: Reactome:666743 "Glycogen synthesis" xref: Reactome:672848 "Glycogen synthesis" xref: Reactome:678651 "Glycogen synthesis" xref: Reactome:683527 "Glycogen synthesis" xref: Reactome:689729 "Glycogen synthesis" xref: Reactome:701460 "Glycogen synthesis" xref: Reactome:70302 "Glycogen synthesis" xref: Reactome:716031 "Glycogen synthesis" xref: Reactome:720726 "Glycogen synthesis" xref: Reactome:728080 "Glycogen synthesis" xref: Reactome:730981 "Glycogen synthesis" xref: Reactome:735609 "Glycogen synthesis" xref: Reactome:736560 "Glycogen synthesis" xref: Reactome:738521 "Glycogen synthesis" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0005979 name: regulation of glycogen biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glycogen anabolism" EXACT [] synonym: "regulation of glycogen biosynthesis" EXACT [] synonym: "regulation of glycogen formation" EXACT [] synonym: "regulation of glycogen synthesis" EXACT [] is_a: GO:0010962 ! regulation of glucan biosynthetic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005978 ! glycogen biosynthetic process relationship: regulates GO:0005978 ! glycogen biosynthetic process [Term] id: GO:0005980 name: glycogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycogen breakdown" EXACT [] synonym: "glycogen catabolism" EXACT [] synonym: "glycogen degradation" EXACT [] xref: MetaCyc:GLYCOCAT-PWY xref: Reactome:562512 "Glycogen breakdown (glycogenolysis)" xref: Reactome:588138 "Glycogen breakdown (glycogenolysis)" xref: Reactome:608906 "Glycogen breakdown (glycogenolysis)" xref: Reactome:633588 "Glycogen breakdown (glycogenolysis)" xref: Reactome:645648 "Glycogen breakdown (glycogenolysis)" xref: Reactome:655596 "Glycogen breakdown (glycogenolysis)" xref: Reactome:661154 "Glycogen breakdown (glycogenolysis)" xref: Reactome:666667 "Glycogen breakdown (glycogenolysis)" xref: Reactome:672759 "Glycogen breakdown (glycogenolysis)" xref: Reactome:678774 "Glycogen breakdown (glycogenolysis)" xref: Reactome:683701 "Glycogen breakdown (glycogenolysis)" xref: Reactome:689914 "Glycogen breakdown (glycogenolysis)" xref: Reactome:701682 "Glycogen breakdown (glycogenolysis)" xref: Reactome:70221 "Glycogen breakdown (glycogenolysis)" xref: Reactome:716259 "Glycogen breakdown (glycogenolysis)" xref: Reactome:720803 "Glycogen breakdown (glycogenolysis)" xref: Reactome:728208 "Glycogen breakdown (glycogenolysis)" xref: Reactome:731042 "Glycogen breakdown (glycogenolysis)" xref: Reactome:735644 "Glycogen breakdown (glycogenolysis)" xref: Reactome:736588 "Glycogen breakdown (glycogenolysis)" xref: Reactome:738553 "Glycogen breakdown (glycogenolysis)" is_a: GO:0005977 ! glycogen metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005981 name: regulation of glycogen catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glycogen." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glycogen breakdown" EXACT [] synonym: "regulation of glycogen catabolism" EXACT [] synonym: "regulation of glycogen degradation" EXACT [] is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process is_a: GO:0070873 ! regulation of glycogen metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005980 ! glycogen catabolic process relationship: regulates GO:0005980 ! glycogen catabolic process [Term] id: GO:0005982 name: starch metabolic process namespace: biological_process def: "The chemical reactions and pathways involving starch, the most important reserve polysaccharide in plants. It is a glucan consisting of two components, amylose and amylopectin, which are both glucose homopolymers. Starch is synthesized as a temporary storage form of carbon and can be catabolized to produce sucrose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "starch metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process [Term] id: GO:0005983 name: starch catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of starch, the most important reserve polysaccharide in plants." [GOC:ai] subset: gosubset_prok synonym: "starch breakdown" EXACT [] synonym: "starch catabolism" EXACT [] synonym: "starch degradation" EXACT [] xref: MetaCyc:PWY-842 is_a: GO:0005982 ! starch metabolic process is_a: GO:0009251 ! glucan catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0005984 name: disaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any disaccharide, sugars composed of two monosaccharide units." [GOC:jl, ISBN:01928006X] subset: gosubset_prok synonym: "disaccharide metabolism" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005985 name: sucrose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0005986 name: sucrose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose anabolism" EXACT [] synonym: "sucrose biosynthesis" EXACT [] synonym: "sucrose formation" EXACT [] synonym: "sucrose synthesis" EXACT [] xref: MetaCyc:SUCSYN-PWY is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005987 name: sucrose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose, the disaccharide fructofuranosyl-glucopyranoside." [GOC:go_curators] subset: gosubset_prok synonym: "sucrose breakdown" EXACT [] synonym: "sucrose catabolism" EXACT [] synonym: "sucrose degradation" EXACT [] is_a: GO:0005985 ! sucrose metabolic process is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005988 name: lactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005989 name: lactose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose anabolism" EXACT [] synonym: "lactose biosynthesis" EXACT [] synonym: "lactose formation" EXACT [] synonym: "lactose synthesis" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005990 name: lactose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lactose, the disaccharide galactopyranosyl-glucose." [GOC:go_curators] subset: gosubset_prok synonym: "lactose breakdown" EXACT [] synonym: "lactose catabolism" EXACT [] synonym: "lactose degradation" EXACT [] is_a: GO:0005988 ! lactose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005991 name: trehalose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose metabolic process" EXACT [] synonym: "mycose metabolism" EXACT [] synonym: "mykose metabolic process" EXACT [] synonym: "mykose metabolism" EXACT [] synonym: "trehalose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0016137 ! glycoside metabolic process [Term] id: GO:0005992 name: trehalose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose biosynthesis" EXACT [] synonym: "mycose biosynthetic process" EXACT [] synonym: "mykose biosynthesis" EXACT [] synonym: "mykose biosynthetic process" EXACT [] synonym: "trehalose anabolism" EXACT [] synonym: "trehalose biosynthesis" EXACT [] synonym: "trehalose formation" EXACT [] synonym: "trehalose synthesis" EXACT [] xref: MetaCyc:PWY-881 xref: MetaCyc:TREHALOSESYN-PWY xref: MetaCyc:TRESYN-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0046351 ! disaccharide biosynthetic process [Term] id: GO:0005993 name: trehalose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi." [GOC:jl, ISBN:0028623819] subset: gosubset_prok synonym: "mycose catabolic process" EXACT [] synonym: "mycose catabolism" EXACT [] synonym: "mykose catabolic process" EXACT [] synonym: "mykose catabolism" EXACT [] synonym: "trehalose breakdown" EXACT [] synonym: "trehalose catabolism" EXACT [] synonym: "trehalose degradation" EXACT [] xref: MetaCyc:TREDEGLOW-PWY is_a: GO:0005991 ! trehalose metabolic process is_a: GO:0016139 ! glycoside catabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005994 name: melibiose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] subset: gosubset_prok synonym: "melibiose metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process [Term] id: GO:0005995 name: melibiose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of melibiose, the disaccharide 6-O-alpha-D-galactopyranosyl-D-glucose." [ISBN:0198547684] subset: gosubset_prok synonym: "melibiose breakdown" EXACT [] synonym: "melibiose catabolism" EXACT [] synonym: "melibiose degradation" EXACT [] is_a: GO:0005994 ! melibiose metabolic process is_a: GO:0046352 ! disaccharide catabolic process [Term] id: GO:0005996 name: monosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monosaccharide metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0005997 name: xylulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process [Term] id: GO:0005998 name: xylulose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose breakdown" EXACT [] synonym: "xylulose catabolism" EXACT [] synonym: "xylulose degradation" EXACT [] xref: MetaCyc:XYLCAT-PWY is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019323 ! pentose catabolic process [Term] id: GO:0005999 name: xylulose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xylulose, the ketopentose threo-2-pentulose." [ISBN:0198547684] subset: gosubset_prok synonym: "xylulose anabolism" EXACT [] synonym: "xylulose biosynthesis" EXACT [] synonym: "xylulose formation" EXACT [] synonym: "xylulose synthesis" EXACT [] xref: Reactome:163754 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:563086 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:588697 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:609439 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:634137 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:645647 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:655976 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:661153 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:666937 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:673060 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:678773 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:683702 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:689913 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:701681 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:716258 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:720805 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:728207 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:731043 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:733088 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:733909 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:735643 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:736587 "Insulin effects increased synthesis of Xylulose-5-Phosphate" xref: Reactome:738554 "Insulin effects increased synthesis of Xylulose-5-Phosphate" is_a: GO:0005997 ! xylulose metabolic process is_a: GO:0019322 ! pentose biosynthetic process [Term] id: GO:0006000 name: fructose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose, the ketohexose arabino-2-hexulose. Fructose exists in a open chain form or as a ring compound. D-fructose is the sweetest of the sugars and is found free in a large number of fruits and honey." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose metabolism" EXACT [] xref: Wikipedia:Fructose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006001 name: fructose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructose, the ketohexose arabino-2-hexulose." [GOC:ai] subset: gosubset_prok synonym: "fructose breakdown" EXACT [] synonym: "fructose catabolism" EXACT [] synonym: "fructose degradation" EXACT [] xref: Reactome:562938 "Fructose catabolism" xref: Reactome:588559 "Fructose catabolism" xref: Reactome:609436 "Fructose catabolism" xref: Reactome:633990 "Fructose catabolism" xref: Reactome:645550 "Fructose catabolism" xref: Reactome:655973 "Fructose catabolism" xref: Reactome:672971 "Fructose catabolism" xref: Reactome:683698 "Fructose catabolism" xref: Reactome:701678 "Fructose catabolism" xref: Reactome:70350 "Fructose catabolism" xref: Reactome:716177 "Fructose catabolism" xref: Reactome:728204 "Fructose catabolism" xref: Reactome:731041 "Fructose catabolism" xref: Reactome:733062 "Fructose catabolism" is_a: GO:0006000 ! fructose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006002 name: fructose 6-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 6-phosphate, also known as F6P. The D-enantiomer is an important intermediate in glycolysis, gluconeogenesis, and fructose metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose 6-phosphate metabolism" EXACT [] is_a: GO:0006000 ! fructose metabolic process [Term] id: GO:0006003 name: fructose 2,6-bisphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructose 2,6-bisphosphate. The D enantiomer is an important regulator of the glycolytic and gluconeogenic pathways. It inhibits fructose 1,6-bisphosphatase and activates phosphofructokinase." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fructose 2,6-bisphosphate metabolism" EXACT [] is_a: GO:0006000 ! fructose metabolic process [Term] id: GO:0006004 name: fucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fucose, or 6-deoxygalactose, which has two enantiomers, D-fucose and L-fucose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fucose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006005 name: L-fucose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-fucose (6-deoxy-L-galactose)." [GOC:jl] subset: gosubset_prok synonym: "L-fucose anabolism" EXACT [] synonym: "L-fucose biosynthesis" EXACT [] synonym: "L-fucose formation" EXACT [] synonym: "L-fucose synthesis" EXACT [] is_a: GO:0042353 ! fucose biosynthetic process is_a: GO:0042354 ! L-fucose metabolic process [Term] id: GO:0006006 name: glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cellular glucose metabolic process" EXACT [GOC:vw] synonym: "glucose metabolism" EXACT [] xref: Reactome:562513 "Glucose metabolism" xref: Reactome:588139 "Glucose metabolism" xref: Reactome:608907 "Glucose metabolism" xref: Reactome:633589 "Glucose metabolism" xref: Reactome:645265 "Glucose metabolism" xref: Reactome:655597 "Glucose metabolism" xref: Reactome:660920 "Glucose metabolism" xref: Reactome:666668 "Glucose metabolism" xref: Reactome:672760 "Glucose metabolism" xref: Reactome:678514 "Glucose metabolism" xref: Reactome:683471 "Glucose metabolism" xref: Reactome:689674 "Glucose metabolism" xref: Reactome:701411 "Glucose metabolism" xref: Reactome:70326 "Glucose metabolism" xref: Reactome:715982 "Glucose metabolism" xref: Reactome:720653 "Glucose metabolism" xref: Reactome:727929 "Glucose metabolism" xref: Reactome:730899 "Glucose metabolism" xref: Reactome:732991 "Glucose metabolism" xref: Reactome:733836 "Glucose metabolism" xref: Reactome:735539 "Glucose metabolism" xref: Reactome:736525 "Glucose metabolism" xref: Reactome:738450 "Glucose metabolism" is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006007 name: glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucose, the aldohexose gluco-hexose." [GOC:ai] subset: gosubset_prok synonym: "glucose breakdown" EXACT [] synonym: "glucose catabolism" EXACT [] synonym: "glucose degradation" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0019320 ! hexose catabolic process [Term] id: GO:0006009 name: glucose 1-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into glucose 1-phosphate to produce glucose bisphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0019255 ! glucose 1-phosphate metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0006011 name: UDP-glucose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucose metabolism" EXACT [] is_a: GO:0006006 ! glucose metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006012 name: galactose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactose, the aldohexose galacto-hexose. D-galactose is widely distributed in combined form in plants, animals and microorganisms as a constituent of oligo- and polysaccharides; it also occurs in galactolipids and as its glucoside in lactose and melibiose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "galactose metabolism" EXACT [] xref: Wikipedia:Galactose is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006013 name: mannose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannose metabolism" EXACT [] is_a: GO:0019318 ! hexose metabolic process [Term] id: GO:0006014 name: D-ribose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving D-ribose (ribo-pentose). As beta-D-ribofuranose, D-ribose forms the glycose moiety of all ribonucleosides, ribonucleotides and ribonucleic acids, and also of ribose phosphates, various glycosides, some coenzymes and some forms of vitamin B12." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "D-ribose metabolism" EXACT [] is_a: GO:0019321 ! pentose metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006015 name: 5-phosphoribose 1-diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 5-phosphoribose 1-diphosphate, also known as 5-phosphoribosyl-1-pyrophosphate." [GOC:ai] subset: gosubset_prok synonym: "5-phosphoribose 1-diphosphate anabolism" EXACT [] synonym: "5-phosphoribose 1-diphosphate biosynthesis" EXACT [] synonym: "5-phosphoribose 1-diphosphate formation" EXACT [] synonym: "5-phosphoribose 1-diphosphate synthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthesis" EXACT [] synonym: "5-phosphoribosyl-1-pyrophosphate biosynthetic process" EXACT [] synonym: "PRPP biosynthetic process" EXACT [] xref: MetaCyc:PWY0-661 xref: Reactome:563088 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:588699 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:609441 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:634138 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:645649 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:655978 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:661155 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:666938 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:673061 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:678775 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:683703 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:689915 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:701683 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:716260 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:720806 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:728210 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:731044 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:733090 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:733910 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:735645 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:736589 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:73843 "5-Phosphoribose 1-diphosphate biosynthesis" xref: Reactome:738556 "5-Phosphoribose 1-diphosphate biosynthesis" is_a: GO:0046390 ! ribose phosphate biosynthetic process is_a: GO:0046391 ! 5-phosphoribose 1-diphosphate metabolic process [Term] id: GO:0006016 name: 2-deoxyribose 1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 2-deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-deoxyribose 1-phosphate anabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate biosynthesis" EXACT [] synonym: "2-deoxyribose 1-phosphate formation" EXACT [] synonym: "2-deoxyribose 1-phosphate synthesis" EXACT [] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process [Term] id: GO:0006017 name: deoxyribose 1,5-bisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of deoxyribose 1,5-bisphosphate, the diphosphorylated sugar 1,5-diphospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "deoxyribose 1,5-bisphosphate anabolism" EXACT [] synonym: "deoxyribose 1,5-bisphosphate biosynthesis" EXACT [] synonym: "deoxyribose 1,5-bisphosphate formation" EXACT [] synonym: "deoxyribose 1,5-bisphosphate synthesis" EXACT [] is_a: GO:0046385 ! deoxyribose phosphate biosynthetic process is_a: GO:0046387 ! deoxyribose 1,5-bisphosphate metabolic process [Term] id: GO:0006018 name: 2-deoxyribose 1-phosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyribose 1-phosphate, the phosphorylated sugar 1-phospho-2-deoxyribose." [GOC:ai] subset: gosubset_prok synonym: "2-deoxyribose 1-phosphate breakdown" EXACT [] synonym: "2-deoxyribose 1-phosphate catabolism" EXACT [] synonym: "2-deoxyribose 1-phosphate degradation" EXACT [] synonym: "deoxyribose 1-phosphate catabolic process" EXACT [GOC:mah] is_a: GO:0046384 ! 2-deoxyribose 1-phosphate metabolic process is_a: GO:0046386 ! deoxyribose phosphate catabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0006019 name: deoxyribose 5-phosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into deoxyribose 5-phosphate to produce deoxyribose bisphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0046389 ! deoxyribose 5-phosphate metabolic process is_a: GO:0046835 ! carbohydrate phosphorylation [Term] id: GO:0006020 name: inositol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684] subset: gosubset_prok synonym: "inositol metabolism" EXACT [] synonym: "myo-inositol metabolic process" NARROW [] synonym: "myo-inositol metabolism" NARROW [] synonym: "vitamin Bh metabolic process" EXACT [] synonym: "vitamin Bh metabolism" EXACT [] xref: Wikipedia:Inositol is_a: GO:0019751 ! polyol metabolic process is_a: GO:0044262 ! cellular carbohydrate metabolic process [Term] id: GO:0006021 name: inositol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inositol, 1,2,3,4,5,6-cyclohexanehexol, a growth factor for animals and microorganisms." [ChEBI:24848, ISBN:0198547684] subset: gosubset_prok synonym: "inositol anabolism" EXACT [] synonym: "inositol biosynthesis" EXACT [] synonym: "inositol formation" EXACT [] synonym: "inositol synthesis" EXACT [] synonym: "myo-inositol biosynthesis" NARROW [] synonym: "myo-inositol biosynthetic process" NARROW [] synonym: "vitamin Bh biosynthesis" EXACT [] synonym: "vitamin Bh biosynthetic process" EXACT [] is_a: GO:0006020 ! inositol metabolic process is_a: GO:0034637 ! cellular carbohydrate biosynthetic process is_a: GO:0046173 ! polyol biosynthetic process [Term] id: GO:0006022 name: aminoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan metabolism" EXACT [] is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0006023 name: aminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan anabolism" EXACT [] synonym: "aminoglycan biosynthesis" EXACT [] synonym: "aminoglycan formation" EXACT [] synonym: "aminoglycan synthesis" EXACT [] is_a: GO:0000271 ! polysaccharide biosynthetic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006024 name: glycosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosaminoglycans, any of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] subset: gosubset_prok synonym: "glycosaminoglycan anabolism" EXACT [] synonym: "glycosaminoglycan biosynthesis" EXACT [] synonym: "glycosaminoglycan formation" EXACT [] synonym: "glycosaminoglycan synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006025 name: galactosaminoglycan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] subset: gosubset_prok synonym: "galactosaminoglycan anabolism" EXACT [] synonym: "galactosaminoglycan biosynthesis" EXACT [] synonym: "galactosaminoglycan formation" EXACT [] synonym: "galactosaminoglycan synthesis" EXACT [] is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006026 name: aminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aminoglycans, any polymer containing amino groups that consists of more than about 10 monosaccharide residues joined to each other by glycosidic linkages." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminoglycan breakdown" EXACT [] synonym: "aminoglycan catabolism" EXACT [] synonym: "aminoglycan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006027 name: glycosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycosaminoglycans, any one of a group of polysaccharides that contain amino sugars." [ISBN:0192800981] subset: gosubset_prok synonym: "glycosaminoglycan breakdown" EXACT [] synonym: "glycosaminoglycan catabolism" EXACT [] synonym: "glycosaminoglycan degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0030203 ! glycosaminoglycan metabolic process [Term] id: GO:0006028 name: galactosaminoglycan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosaminoglycans, any of a group of polysaccharides that contain amino sugars derived from the galactose." [GOC:ai] subset: gosubset_prok synonym: "galactosaminoglycan breakdown" EXACT [] synonym: "galactosaminoglycan catabolism" EXACT [] synonym: "galactosaminoglycan degradation" EXACT [] is_a: GO:0006027 ! glycosaminoglycan catabolic process is_a: GO:0046350 ! galactosaminoglycan metabolic process [Term] id: GO:0006029 name: proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proteoglycans, any glycoprotein in which the carbohydrate units are glycosaminoglycans." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proteoglycan metabolism" EXACT [] synonym: "proteoglycan sulfate transfer" NARROW [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006030 name: chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine metabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine metabolism" EXACT [] synonym: "chitin metabolism" EXACT [] is_a: GO:0006022 ! aminoglycan metabolic process [Term] id: GO:0006031 name: chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine biosynthesis" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine biosynthetic process" EXACT [] synonym: "chitin anabolism" EXACT [] synonym: "chitin biosynthesis" EXACT [] synonym: "chitin formation" EXACT [] synonym: "chitin synthesis" EXACT [] is_a: GO:0006023 ! aminoglycan biosynthetic process is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006032 name: chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "beta-1,4-linked N-acetylglucosamine catabolic process" EXACT [] synonym: "beta-1,4-linked N-acetylglucosamine catabolism" EXACT [] synonym: "chitin breakdown" EXACT [] synonym: "chitin catabolism" EXACT [] synonym: "chitin degradation" EXACT [] is_a: GO:0006026 ! aminoglycan catabolic process is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006033 name: chitin localization namespace: biological_process def: "A process by which chitin is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of chitin localization" EXACT [] is_a: GO:0033037 ! polysaccharide localization [Term] id: GO:0006034 name: cuticle chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process [Term] id: GO:0006035 name: cuticle chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin anabolism" EXACT [] synonym: "cuticle chitin biosynthesis" EXACT [] synonym: "cuticle chitin formation" EXACT [] synonym: "cuticle chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006034 ! cuticle chitin metabolic process relationship: part_of GO:0040003 ! chitin-based cuticle development [Term] id: GO:0006036 name: cuticle chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cuticle chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in cuticles." [GOC:ai] synonym: "cuticle chitin breakdown" EXACT [] synonym: "cuticle chitin catabolism" EXACT [] synonym: "cuticle chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006034 ! cuticle chitin metabolic process [Term] id: GO:0006037 name: cell wall chitin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] subset: gosubset_prok synonym: "cell wall chitin metabolism" EXACT [] is_a: GO:0006030 ! chitin metabolic process is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0006038 name: cell wall chitin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] synonym: "cell wall chitin anabolism" EXACT [] synonym: "cell wall chitin biosynthesis" EXACT [] synonym: "cell wall chitin formation" EXACT [] synonym: "cell wall chitin synthesis" EXACT [] is_a: GO:0006031 ! chitin biosynthetic process is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0070592 ! cell wall polysaccharide biosynthetic process [Term] id: GO:0006039 name: cell wall chitin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cell wall chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues, found in the walls of cells." [GOC:ai] subset: gosubset_prok synonym: "cell wall chitin breakdown" EXACT [] synonym: "cell wall chitin catabolism" EXACT [] synonym: "cell wall chitin degradation" EXACT [] is_a: GO:0006032 ! chitin catabolic process is_a: GO:0006037 ! cell wall chitin metabolic process is_a: GO:0016998 ! cell wall macromolecule catabolic process [Term] id: GO:0006040 name: amino sugar metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino sugar, sugars containing an amino group in place of a hydroxyl group." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "amino sugar metabolism" EXACT [] synonym: "aminosaccharide metabolic process" EXACT [] synonym: "aminosaccharide metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process [Term] id: GO:0006041 name: glucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine metabolic process" EXACT [] synonym: "chitosamine metabolism" EXACT [] synonym: "glucosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006042 name: glucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine biosynthesis" EXACT [] synonym: "chitosamine biosynthetic process" EXACT [] synonym: "glucosamine anabolism" EXACT [] synonym: "glucosamine biosynthesis" EXACT [] synonym: "glucosamine formation" EXACT [] synonym: "glucosamine synthesis" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:0046349 ! amino sugar biosynthetic process [Term] id: GO:0006043 name: glucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosamine (2-amino-2-deoxyglucopyranose), an aminodeoxysugar that occurs in combined form in chitin." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chitosamine catabolic process" EXACT [] synonym: "chitosamine catabolism" EXACT [] synonym: "glucosamine breakdown" EXACT [] synonym: "glucosamine catabolism" EXACT [] synonym: "glucosamine degradation" EXACT [] xref: MetaCyc:GLUAMCAT-PWY is_a: GO:0006041 ! glucosamine metabolic process is_a: GO:0046348 ! amino sugar catabolic process [Term] id: GO:0006044 name: N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006041 ! glucosamine metabolic process [Term] id: GO:0006045 name: N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine anabolism" EXACT [] synonym: "N-acetylglucosamine biosynthesis" EXACT [] synonym: "N-acetylglucosamine formation" EXACT [] synonym: "N-acetylglucosamine synthesis" EXACT [] is_a: GO:0006042 ! glucosamine biosynthetic process is_a: GO:0006044 ! N-acetylglucosamine metabolic process [Term] id: GO:0006046 name: N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide moiety of a glycoprotein." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylglucosamine breakdown" EXACT [] synonym: "N-acetylglucosamine catabolism" EXACT [] synonym: "N-acetylglucosamine degradation" EXACT [] is_a: GO:0006043 ! glucosamine catabolic process is_a: GO:0006044 ! N-acetylglucosamine metabolic process [Term] id: GO:0006047 name: UDP-N-acetylglucosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylglucosamine metabolism" EXACT [] is_a: GO:0006044 ! N-acetylglucosamine metabolic process is_a: GO:0009225 ! nucleotide-sugar metabolic process [Term] id: GO:0006048 name: UDP-N-acetylglucosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-GlcNAc biosynthesis" EXACT [] synonym: "UDP-GlcNAc biosynthetic process" EXACT [] synonym: "UDP-N-acetylglucosamine anabolism" EXACT [] synonym: "UDP-N-acetylglucosamine biosynthesis" EXACT [] synonym: "UDP-N-acetylglucosamine formation" EXACT [] synonym: "UDP-N-acetylglucosamine synthesis" EXACT [] xref: MetaCyc:UDPNAGSYN-PWY is_a: GO:0006045 ! N-acetylglucosamine biosynthetic process is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process [Term] id: GO:0006049 name: UDP-N-acetylglucosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-N-acetylglucosamine, a substance composed of N-acetylglucosamine, a common structural unit of oligosaccharides, in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-N-acetylglucosamine breakdown" EXACT [] synonym: "UDP-N-acetylglucosamine catabolism" EXACT [] synonym: "UDP-N-acetylglucosamine degradation" EXACT [] is_a: GO:0006046 ! N-acetylglucosamine catabolic process is_a: GO:0006047 ! UDP-N-acetylglucosamine metabolic process [Term] id: GO:0006050 name: mannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosomine, 2-amino-2-deoxymannose; the D-isomer is a constituent of neuraminic acids as well as mucolipids and mucoproteins." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "mannosamine metabolism" EXACT [] is_a: GO:0006040 ! amino sugar metabolic process [Term] id: GO:0006051 name: N-acetylmannosamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine metabolism" EXACT [] is_a: GO:0006050 ! mannosamine metabolic process [Term] id: GO:0006052 name: N-acetylmannosamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine anabolism" EXACT [] synonym: "N-acetylmannosamine biosynthesis" EXACT [] synonym: "N-acetylmannosamine formation" EXACT [] synonym: "N-acetylmannosamine synthesis" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046347 ! mannosamine biosynthetic process [Term] id: GO:0006053 name: N-acetylmannosamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of N-acetylmannosamine, the acetylated derivative of mannosamine, 2-amino-2-deoxymannose." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylmannosamine breakdown" EXACT [] synonym: "N-acetylmannosamine catabolism" EXACT [] synonym: "N-acetylmannosamine degradation" EXACT [] is_a: GO:0006051 ! N-acetylmannosamine metabolic process is_a: GO:0046346 ! mannosamine catabolic process [Term] id: GO:0006054 name: N-acetylneuraminate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving N-acetylneuraminate, the anion of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-acetylneuraminate metabolism" EXACT [] synonym: "sialic acid metabolic process" BROAD [] synonym: "sialic acid metabolism" BROAD [] is_a: GO:0006040 ! amino sugar metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006055 name: CMP-N-acetylneuraminate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP-N-acetylneuraminate, a substance composed of 5-(acetylamino)-3,5-dideoxy-D-glycero-D-galacto-non-3-ulosonic acid in glycosidic linkage with cytidine monophosphate." [GOC:ai] subset: gosubset_prok synonym: "CMP-N-acetylneuraminate anabolism" EXACT [] synonym: "CMP-N-acetylneuraminate biosynthesis" EXACT [] synonym: "CMP-N-acetylneuraminate formation" EXACT [] synonym: "CMP-N-acetylneuraminate synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0046380 ! N-acetylneuraminate biosynthetic process is_a: GO:0046381 ! CMP-N-acetylneuraminate metabolic process [Term] id: GO:0006056 name: mannoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein metabolism" EXACT [] is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006057 name: mannoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein anabolism" EXACT [] synonym: "mannoprotein biosynthesis" EXACT [] synonym: "mannoprotein formation" EXACT [] synonym: "mannoprotein synthesis" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006058 name: mannoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mannoproteins, any protein that contains covalently bound mannose residues other than as a moiety of nucleic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mannoprotein breakdown" EXACT [] synonym: "mannoprotein catabolism" EXACT [] synonym: "mannoprotein degradation" EXACT [] is_a: GO:0006056 ! mannoprotein metabolic process is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006059 name: hexitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hexitols, any alditol with a chain of six carbon atoms in the molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "hexitol metabolism" EXACT [] synonym: "sugar alcohol (hexitol) metabolic process" EXACT [] synonym: "sugar alcohol (hexitol) metabolism" EXACT [] is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006060 name: sorbitol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol metabolism" EXACT [] xref: MetaCyc:P461-PWY is_a: GO:0006059 ! hexitol metabolic process [Term] id: GO:0006061 name: sorbitol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol anabolism" EXACT [] synonym: "sorbitol biosynthesis" EXACT [] synonym: "sorbitol formation" EXACT [] synonym: "sorbitol synthesis" EXACT [] is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019406 ! hexitol biosynthetic process [Term] id: GO:0006062 name: sorbitol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sorbitol (D-glucitol), one of the ten stereoisomeric hexitols. It can be derived from glucose by reduction of the aldehyde group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sorbitol breakdown" EXACT [] synonym: "sorbitol catabolism" EXACT [] synonym: "sorbitol degradation" EXACT [] xref: MetaCyc:SORBDEG-PWY is_a: GO:0006060 ! sorbitol metabolic process is_a: GO:0019407 ! hexitol catabolic process [Term] id: GO:0006063 name: uronic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving uronic acid, any monocarboxylic acid formally derived by oxidizing to a carboxyl group the terminal hydroxymethylene group of either an aldose with four or more carbon atoms in the molecule, or of any glycoside derived from such an aldose." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "uronic acid metabolism" EXACT [] is_a: GO:0005996 ! monosaccharide metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006064 name: glucuronate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glucuronate breakdown" EXACT [] synonym: "glucuronate catabolism" EXACT [] synonym: "glucuronate degradation" EXACT [] is_a: GO:0016052 ! carbohydrate catabolic process is_a: GO:0019585 ! glucuronate metabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0006065 name: UDP-glucuronate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-glucuronate, a substance composed of glucuronic acid in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucuronate anabolism" EXACT [] synonym: "UDP-glucuronate biosynthesis" EXACT [] synonym: "UDP-glucuronate formation" EXACT [] synonym: "UDP-glucuronate synthesis" EXACT [] xref: MetaCyc:PWY-4841 xref: Reactome:173599 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:563398 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:589017 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:609743 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:634437 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:645901 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:656219 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:661349 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:667135 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:673274 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:678958 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:683885 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:690137 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:701884 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:716458 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:720958 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:728420 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:733150 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:733960 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:735691 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:736637 "Formation of the active cofactor, UDP-glucuronate" xref: Reactome:738631 "Formation of the active cofactor, UDP-glucuronate" is_a: GO:0046398 ! UDP-glucuronate metabolic process is_a: GO:0046399 ! glucuronate biosynthetic process [Term] id: GO:0006066 name: alcohol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alcohols, any of a class of compounds containing one or more hydroxyl groups attached to a saturated carbon atom." [ChEBI:30879, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "alcohol metabolism" EXACT [] is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006067 name: ethanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol metabolism" EXACT [] is_a: GO:0034308 ! monohydric alcohol metabolic process [Term] id: GO:0006068 name: ethanol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol breakdown" EXACT [] synonym: "ethanol catabolism" EXACT [] synonym: "ethanol degradation" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0034310 ! monohydric alcohol catabolic process [Term] id: GO:0006069 name: ethanol oxidation namespace: biological_process def: "An ethanol metabolic process by which ethanol is converted to acetyl-CoA via acetaldehyde and acetate." [GOC:mah, MetaCyc:PWY66-161, MetaCyc:PWY66-162, MetaCyc:PWY66-21] subset: gosubset_prok xref: Reactome:562650 "Ethanol oxidation" xref: Reactome:588275 "Ethanol oxidation" xref: Reactome:609029 "Ethanol oxidation" xref: Reactome:633719 "Ethanol oxidation" xref: Reactome:645332 "Ethanol oxidation" xref: Reactome:655706 "Ethanol oxidation" xref: Reactome:660975 "Ethanol oxidation" xref: Reactome:666750 "Ethanol oxidation" xref: Reactome:672855 "Ethanol oxidation" xref: Reactome:678573 "Ethanol oxidation" xref: Reactome:683535 "Ethanol oxidation" xref: Reactome:689737 "Ethanol oxidation" xref: Reactome:701468 "Ethanol oxidation" xref: Reactome:71384 "Ethanol oxidation" xref: Reactome:716039 "Ethanol oxidation" xref: Reactome:727989 "Ethanol oxidation" xref: Reactome:730922 "Ethanol oxidation" xref: Reactome:733027 "Ethanol oxidation" xref: Reactome:733862 "Ethanol oxidation" xref: Reactome:735584 "Ethanol oxidation" xref: Reactome:736543 "Ethanol oxidation" xref: Reactome:738497 "Ethanol oxidation" is_a: GO:0006067 ! ethanol metabolic process [Term] id: GO:0006070 name: octanol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving octanol, the 8-carbon alcohol with the formula C8H17OH." [GOC:go_curators] subset: gosubset_prok synonym: "octanol metabolism" EXACT [] is_a: GO:0034308 ! monohydric alcohol metabolic process [Term] id: GO:0006071 name: glycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol metabolism" EXACT [] xref: MetaCyc:GLYCEROLMETAB-PWY is_a: GO:0019400 ! alditol metabolic process [Term] id: GO:0006072 name: glycerol-3-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol-3-phosphate metabolism" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0006796 ! phosphate metabolic process is_a: GO:0019637 ! organophosphate metabolic process [Term] id: GO:0006073 name: cellular glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucans, polysaccharides consisting only of glucose residues." [ISBN:0198547684] subset: gosubset_prok synonym: "cellular glucan metabolism" EXACT [] is_a: GO:0044042 ! glucan metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0006074 name: 1,3-beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "1,3-beta-glucan metabolism" EXACT [] synonym: "beta-1,3 glucan metabolic process" EXACT [] synonym: "beta-1,3 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006075 name: 1,3-beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,3 glucans, compounds composed of glucose residues linked by 1,3-beta-D-glucosidic bonds." [GOC:ai] synonym: "1,3-beta-glucan anabolism" EXACT [] synonym: "1,3-beta-glucan biosynthesis" EXACT [] synonym: "1,3-beta-glucan formation" EXACT [] synonym: "1,3-beta-glucan synthesis" EXACT [] synonym: "beta-1,3 glucan anabolism" EXACT [] synonym: "beta-1,3 glucan biosynthesis" EXACT [] synonym: "beta-1,3 glucan biosynthetic process" EXACT [] synonym: "beta-1,3 glucan formation" EXACT [] synonym: "beta-1,3 glucan synthesis" EXACT [] is_a: GO:0006074 ! 1,3-beta-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006076 name: 1,3-beta-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-1,3 glucans." [GOC:ai] subset: gosubset_prok synonym: "1,3-beta-glucan breakdown" EXACT [] synonym: "1,3-beta-glucan catabolism" EXACT [] synonym: "1,3-beta-glucan degradation" EXACT [] synonym: "beta-1,3 glucan breakdown" EXACT [] synonym: "beta-1,3 glucan catabolic process" EXACT [] synonym: "beta-1,3 glucan catabolism" EXACT [] synonym: "beta-1,3 glucan degradation" EXACT [] is_a: GO:0006074 ! 1,3-beta-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006077 name: 1,6-beta-glucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving beta-1,6 glucans, compounds composed of glucose residues linked by 1,6-beta-D-glucosidic bonds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "1,6-beta-glucan metabolism" EXACT [] synonym: "beta-1,6 glucan metabolic process" EXACT [] synonym: "beta-1,6 glucan metabolism" EXACT [] is_a: GO:0051273 ! beta-glucan metabolic process [Term] id: GO:0006078 name: 1,6-beta-glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of beta-1,6 glucans." [GOC:ai] synonym: "1,6-beta-glucan anabolism" EXACT [] synonym: "1,6-beta-glucan biosynthesis" EXACT [] synonym: "1,6-beta-glucan formation" EXACT [] synonym: "1,6-beta-glucan synthesis" EXACT [] synonym: "beta-1,6 glucan anabolism" EXACT [] synonym: "beta-1,6 glucan biosynthesis" EXACT [] synonym: "beta-1,6 glucan biosynthetic process" EXACT [] synonym: "beta-1,6 glucan formation" EXACT [] synonym: "beta-1,6 glucan synthesis" EXACT [] is_a: GO:0006077 ! 1,6-beta-glucan metabolic process is_a: GO:0051274 ! beta-glucan biosynthetic process [Term] id: GO:0006079 name: 1,6-beta-glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of beta-1,6 glucans." [GOC:ai] subset: gosubset_prok synonym: "1,6-beta-glucan breakdown" EXACT [] synonym: "1,6-beta-glucan catabolism" EXACT [] synonym: "1,6-beta-glucan degradation" EXACT [] synonym: "beta-1,6 glucan breakdown" EXACT [] synonym: "beta-1,6 glucan catabolic process" EXACT [] synonym: "beta-1,6 glucan catabolism" EXACT [] synonym: "beta-1,6 glucan degradation" EXACT [] is_a: GO:0006077 ! 1,6-beta-glucan metabolic process is_a: GO:0051275 ! beta-glucan catabolic process [Term] id: GO:0006080 name: substituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a mannan backbone composed of D-mannose unites, substituted with D-glucose and/or D-galactose units." [GOC:tair_curators] subset: gosubset_prok synonym: "substituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0006081 name: cellular aldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "aldehyde metabolism" EXACT [] synonym: "alkanal metabolic process" EXACT [] synonym: "alkanal metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006082 name: organic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "organic acid metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006083 name: acetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetate, the anion of acetic acid." [GOC:go_curators] subset: gosubset_prok synonym: "acetate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006084 name: acetyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [ISBN:0198547684] subset: gosubset_prok synonym: "acetyl coenzyme A metabolic process" EXACT [] synonym: "acetyl coenzyme A metabolism" EXACT [] synonym: "acetyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006085 name: acetyl-CoA biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA, a derivative of coenzyme A in which the sulfhydryl group is acetylated." [GOC:go_curators] subset: gosubset_prok synonym: "acetyl-CoA anabolism" EXACT [] synonym: "acetyl-CoA biosynthesis" EXACT [] synonym: "acetyl-CoA formation" EXACT [] synonym: "acetyl-CoA synthesis" EXACT [] xref: MetaCyc:PWY-5173 is_a: GO:0006084 ! acetyl-CoA metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process [Term] id: GO:0006086 name: acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "acetyl-CoA anabolism from pyruvate" EXACT [] synonym: "acetyl-CoA formation from pyruvate" EXACT [] synonym: "acetyl-CoA synthesis from pyruvate" EXACT [] synonym: "pyruvate dehydrogenase pathway" EXACT [] xref: MetaCyc:PYRUVDEHYD-PWY is_a: GO:0006085 ! acetyl-CoA biosynthetic process is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0006087 name: pyruvate dehydrogenase bypass namespace: biological_process subset: gosubset_prok is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0006088 name: acetate to acetyl-CoA namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0003987 [Term] id: GO:0006089 name: lactate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lactate, the anion of lactic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "2-hydroxypropanoate metabolic process" EXACT [] synonym: "2-hydroxypropanoate metabolism" EXACT [] synonym: "alpha-hydroxypropionate metabolic process" EXACT [] synonym: "alpha-hydroxypropionate metabolism" EXACT [] synonym: "lactate metabolism" EXACT [] is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006090 name: pyruvate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyruvate, 2-oxopropanoate." [GOC:go_curators] subset: gosubset_prok synonym: "pyruvate metabolism" EXACT [] xref: MetaCyc:P41-PWY xref: Reactome:562552 "Pyruvate metabolism" xref: Reactome:588178 "Pyruvate metabolism" xref: Reactome:608946 "Pyruvate metabolism" xref: Reactome:633628 "Pyruvate metabolism" xref: Reactome:645254 "Pyruvate metabolism" xref: Reactome:655635 "Pyruvate metabolism" xref: Reactome:660912 "Pyruvate metabolism" xref: Reactome:666689 "Pyruvate metabolism" xref: Reactome:672785 "Pyruvate metabolism" xref: Reactome:678506 "Pyruvate metabolism" xref: Reactome:683463 "Pyruvate metabolism" xref: Reactome:690081 "Pyruvate metabolism" xref: Reactome:701403 "Pyruvate metabolism" xref: Reactome:70268 "Pyruvate metabolism" xref: Reactome:715974 "Pyruvate metabolism" xref: Reactome:720645 "Pyruvate metabolism" xref: Reactome:728385 "Pyruvate metabolism" xref: Reactome:730896 "Pyruvate metabolism" xref: Reactome:732983 "Pyruvate metabolism" xref: Reactome:733833 "Pyruvate metabolism" xref: Wikipedia:Pyruvic_acid is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0006091 name: generation of precursor metabolites and energy namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances." [GOC:jl] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "energy pathways" BROAD [] synonym: "intermediary metabolism" RELATED [GOC:mah] synonym: "metabolic energy generation" RELATED [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006094 name: gluconeogenesis namespace: biological_process def: "The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "glucose biosynthesis" EXACT [] synonym: "glucose biosynthetic process" EXACT [] xref: MetaCyc:GLUCONEO-PWY xref: Reactome:562563 "Gluconeogenesis" xref: Reactome:588189 "Gluconeogenesis" xref: Reactome:608957 "Gluconeogenesis" xref: Reactome:633639 "Gluconeogenesis" xref: Reactome:645267 "Gluconeogenesis" xref: Reactome:655646 "Gluconeogenesis" xref: Reactome:660922 "Gluconeogenesis" xref: Reactome:666697 "Gluconeogenesis" xref: Reactome:672793 "Gluconeogenesis" xref: Reactome:678516 "Gluconeogenesis" xref: Reactome:683473 "Gluconeogenesis" xref: Reactome:689676 "Gluconeogenesis" xref: Reactome:701413 "Gluconeogenesis" xref: Reactome:70263 "Gluconeogenesis" xref: Reactome:715984 "Gluconeogenesis" xref: Reactome:720655 "Gluconeogenesis" xref: Reactome:727931 "Gluconeogenesis" xref: Reactome:730905 "Gluconeogenesis" xref: Reactome:733061 "Gluconeogenesis" xref: Reactome:733897 "Gluconeogenesis" xref: Reactome:735541 "Gluconeogenesis" xref: Reactome:736527 "Gluconeogenesis" xref: Reactome:738452 "Gluconeogenesis" xref: Wikipedia:Gluconeogenesis is_a: GO:0006006 ! glucose metabolic process is_a: GO:0006090 ! pyruvate metabolic process is_a: GO:0019319 ! hexose biosynthetic process [Term] id: GO:0006096 name: glycolysis namespace: biological_process alt_id: GO:0019641 alt_id: GO:0019642 def: "The chemical reactions and pathways resulting in the breakdown of a monosaccharide (generally glucose) into pyruvate, with the concomitant production of a small amount of ATP. Pyruvate may be converted to ethanol, lactate, or other small molecules, or fed into the TCA cycle." [ISBN:0716720094] subset: gosubset_prok synonym: "anaerobic glycolysis" RELATED [] synonym: "Embden-Meyerhof pathway" EXACT [] synonym: "Embden-Meyerhof-Parnas pathway" EXACT [] synonym: "modifed Embden-Meyerhof pathway" RELATED [] xref: MetaCyc:ANAGLYCOLYSIS-PWY xref: MetaCyc:GLYCOLYSIS xref: MetaCyc:P341-PWY xref: MetaCyc:PWY-1042 xref: MetaCyc:PWY-5484 xref: Reactome:562562 "Glycolysis" xref: Reactome:588188 "Glycolysis" xref: Reactome:608956 "Glycolysis" xref: Reactome:633638 "Glycolysis" xref: Reactome:645264 "Glycolysis" xref: Reactome:655645 "Glycolysis" xref: Reactome:660919 "Glycolysis" xref: Reactome:666696 "Glycolysis" xref: Reactome:672792 "Glycolysis" xref: Reactome:678513 "Glycolysis" xref: Reactome:683470 "Glycolysis" xref: Reactome:689673 "Glycolysis" xref: Reactome:701410 "Glycolysis" xref: Reactome:70171 "Glycolysis" xref: Reactome:715981 "Glycolysis" xref: Reactome:720652 "Glycolysis" xref: Reactome:727928 "Glycolysis" xref: Reactome:730898 "Glycolysis" xref: Reactome:732990 "Glycolysis" xref: Reactome:733835 "Glycolysis" xref: Reactome:735538 "Glycolysis" xref: Reactome:736524 "Glycolysis" xref: Reactome:738449 "Glycolysis" xref: Wikipedia:Glycolysis is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006091 ! generation of precursor metabolites and energy [Term] id: GO:0006097 name: glyoxylate cycle namespace: biological_process def: "A modification of the TCA cycle occurring in some plants and microorganisms, in which isocitrate is cleaved to glyoxylate and succinate. Glyoxylate can then react with acetyl-CoA to form malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyoxylate bypass" EXACT [] xref: MetaCyc:GLYOXYLATE-BYPASS xref: Wikipedia:Glyoxylate_cycle is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0046487 ! glyoxylate metabolic process [Term] id: GO:0006098 name: pentose-phosphate shunt namespace: biological_process def: "The process by which glucose is oxidized, coupled to NADPH synthesis. Glucose 6-P is oxidized with the formation of carbon dioxide (CO2), ribulose 5-phosphate and reduced NADP; ribulose 5-P then enters a series of reactions interconverting sugar phosphates. The pentose phosphate pathway is a major source of reducing equivalents for biosynthesis reactions and is also important for the conversion of hexoses to pentoses." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:PENTOSE-P-PWY] subset: gosubset_prok synonym: "hexose monophosphate pathway" EXACT [] synonym: "pentose phosphate pathway" EXACT [] synonym: "pentose phosphate shunt" EXACT [] synonym: "pentose-phosphate pathway" EXACT [] xref: MetaCyc:PENTOSE-P-PWY xref: Reactome:562637 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:588483 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:609016 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:633706 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:645321 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:655694 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:660968 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:666742 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:672847 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:678569 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:683526 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:689728 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:701459 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:71336 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:716030 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:720804 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:727980 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:730916 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:733020 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:733908 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:735579 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:736538 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Reactome:738489 "Pentose phosphate pathway (hexose monophosphate shunt)" xref: Wikipedia:Pentose_phosphate_pathway is_a: GO:0006007 ! glucose catabolic process is_a: GO:0006740 ! NADPH regeneration [Term] id: GO:0006099 name: tricarboxylic acid cycle namespace: biological_process def: "A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citric acid cycle" EXACT [] synonym: "Krebs cycle" EXACT [] synonym: "TCA cycle" EXACT [] xref: MetaCyc:P105-PWY xref: MetaCyc:P42-PWY xref: MetaCyc:TCA xref: Reactome:562554 "Citric acid cycle (TCA cycle)" xref: Reactome:588180 "Citric acid cycle (TCA cycle)" xref: Reactome:608948 "Citric acid cycle (TCA cycle)" xref: Reactome:633630 "Citric acid cycle (TCA cycle)" xref: Reactome:645256 "Citric acid cycle (TCA cycle)" xref: Reactome:655637 "Citric acid cycle (TCA cycle)" xref: Reactome:660914 "Citric acid cycle (TCA cycle)" xref: Reactome:666691 "Citric acid cycle (TCA cycle)" xref: Reactome:672787 "Citric acid cycle (TCA cycle)" xref: Reactome:678508 "Citric acid cycle (TCA cycle)" xref: Reactome:683465 "Citric acid cycle (TCA cycle)" xref: Reactome:689664 "Citric acid cycle (TCA cycle)" xref: Reactome:701405 "Citric acid cycle (TCA cycle)" xref: Reactome:71403 "Citric acid cycle (TCA cycle)" xref: Reactome:715976 "Citric acid cycle (TCA cycle)" xref: Reactome:720647 "Citric acid cycle (TCA cycle)" xref: Reactome:727922 "Citric acid cycle (TCA cycle)" xref: Reactome:730926 "Citric acid cycle (TCA cycle)" xref: Reactome:732985 "Citric acid cycle (TCA cycle)" xref: Reactome:733880 "Citric acid cycle (TCA cycle)" xref: Reactome:735532 "Citric acid cycle (TCA cycle)" xref: Reactome:736518 "Citric acid cycle (TCA cycle)" xref: Reactome:738443 "Citric acid cycle (TCA cycle)" xref: Wikipedia:Tricarboxylic_acid_cycle is_a: GO:0046356 ! acetyl-CoA catabolic process relationship: part_of GO:0009060 ! aerobic respiration [Term] id: GO:0006100 name: tricarboxylic acid cycle intermediate metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving intermediates of the tricarboxylic acid cycle." [GOC:ai] comment: This term was made obsolete because it is a grouping term that is not useful, but has caused true path violations. synonym: "citric acid cycle intermediate metabolic process" EXACT [] synonym: "citric acid cycle intermediate metabolism" EXACT [] synonym: "Krebs cycle intermediate metabolic process" EXACT [] synonym: "Krebs cycle intermediate metabolism" EXACT [] synonym: "TCA intermediate metabolic process" EXACT [] synonym: "TCA intermediate metabolism" EXACT [] synonym: "tricarboxylic acid cycle intermediate metabolism" EXACT [] is_obsolete: true consider: GO:0006099 consider: GO:0006101 consider: GO:0006103 consider: GO:0006104 consider: GO:0006105 consider: GO:0006106 consider: GO:0006107 consider: GO:0006108 [Term] id: GO:0006101 name: citrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving citrate, 2-hydroxy-1,2,3-propanetricarboyxlate. Citrate is widely distributed in nature and is an important intermediate in the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "citrate metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006102 name: isocitrate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isocitrate, the anion of isocitric acid, 1-hydroxy-1,2,3-propanetricarboxylic acid. Isocitrate is an important intermediate in the TCA cycle and the glycoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isocitrate metabolism" EXACT [] is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006103 name: 2-oxoglutarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxoglutarate, the dianion of 2-oxoglutaric acid. It is a key constituent of the TCA cycle and a key intermediate in amino-acid metabolism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "2-ketoglutarate metabolic process" EXACT [] synonym: "2-ketoglutarate metabolism" EXACT [] synonym: "2-oxoglutarate metabolism" EXACT [] synonym: "alpha-ketoglutarate metabolic process" EXACT [] synonym: "alpha-ketoglutarate metabolism" EXACT [] synonym: "alpha-oxoglutarate metabolic process" EXACT [] synonym: "alpha-oxoglutarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006104 name: succinyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinyl-CoA, a compound composed of the monovalent acyl group 3-carboxypropanoyl, derived from succinic acid by loss of one OH group, linked to coenzyme A." [GOC:ai] subset: gosubset_prok synonym: "succinyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006105 name: succinate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving succinate, also known as butanedioate or ethane dicarboxylate, the dianion of succinic acid. Succinate is an important intermediate in metabolism and a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "succinate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006106 name: fumarate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fumarate, the anion of trans-1,2-ethenedicarboxylic acid, the diastereoisomer of maleate. It is a key intermediate in metabolism and is formed in the TCA cycle from succinate and converted into malate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fumarate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006107 name: oxaloacetate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oxaloacetate, the anion of oxobutanedioic acid, an important intermediate in metabolism, especially as a component of the TCA cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oxaloacetate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006108 name: malate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving malate, the anion of hydroxybutanedioic acid, a chiral hydroxydicarboxylic acid. The (+) enantiomer is an important intermediate in metabolism as a component of both the TCA cycle and the glyoxylate cycle." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "malate metabolism" EXACT [] is_a: GO:0043648 ! dicarboxylic acid metabolic process [Term] id: GO:0006109 name: regulation of carbohydrate metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving carbohydrates." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of carbohydrate metabolism" EXACT [] is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005975 ! carbohydrate metabolic process relationship: regulates GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0006110 name: regulation of glycolysis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of glycolysis." [GOC:go_curators] subset: gosubset_prok is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0043467 ! regulation of generation of precursor metabolites and energy is_a: GO:0043471 ! regulation of cellular carbohydrate catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006096 ! glycolysis relationship: regulates GO:0006096 ! glycolysis [Term] id: GO:0006111 name: regulation of gluconeogenesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gluconeogenesis, the formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of glucose biosynthesis" BROAD [] synonym: "regulation of glucose biosynthetic process" BROAD [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010906 ! regulation of glucose metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006094 ! gluconeogenesis relationship: regulates GO:0006094 ! gluconeogenesis [Term] id: GO:0006112 name: energy reserve metabolic process namespace: biological_process def: "The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "energy reserve metabolism" EXACT [] xref: Reactome:163685 "Integration of energy metabolism" xref: Reactome:562556 "Integration of energy metabolism" xref: Reactome:588182 "Integration of energy metabolism" xref: Reactome:608950 "Integration of energy metabolism" xref: Reactome:633632 "Integration of energy metabolism" xref: Reactome:645258 "Integration of energy metabolism" xref: Reactome:655639 "Integration of energy metabolism" xref: Reactome:660916 "Integration of energy metabolism" xref: Reactome:666693 "Integration of energy metabolism" xref: Reactome:672789 "Integration of energy metabolism" xref: Reactome:678510 "Integration of energy metabolism" xref: Reactome:683467 "Integration of energy metabolism" xref: Reactome:689667 "Integration of energy metabolism" xref: Reactome:701407 "Integration of energy metabolism" xref: Reactome:715978 "Integration of energy metabolism" xref: Reactome:720649 "Integration of energy metabolism" xref: Reactome:727925 "Integration of energy metabolism" xref: Reactome:730902 "Integration of energy metabolism" xref: Reactome:732987 "Integration of energy metabolism" xref: Reactome:733839 "Integration of energy metabolism" xref: Reactome:735535 "Integration of energy metabolism" xref: Reactome:736521 "Integration of energy metabolism" xref: Reactome:738446 "Integration of energy metabolism" is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006113 name: fermentation namespace: biological_process def: "The anaerobic enzymatic conversion of organic compounds, especially carbohydrates, to other compounds, especially to ethyl alcohol, yielding energy in the form of adenosine triphosphate (ATP)." [http://cancerweb.ncl.ac.uk/] subset: goslim_pir subset: gosubset_prok xref: MetaCyc:FERMENTATION-PWY xref: Wikipedia:Fermentation_(biochemistry) is_a: GO:0015980 ! energy derivation by oxidation of organic compounds [Term] id: GO:0006114 name: glycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerol anabolism" EXACT [] synonym: "glycerol biosynthesis" EXACT [] synonym: "glycerol formation" EXACT [] synonym: "glycerol synthesis" EXACT [] is_a: GO:0006071 ! glycerol metabolic process is_a: GO:0019401 ! alditol biosynthetic process relationship: part_of GO:0006113 ! fermentation [Term] id: GO:0006115 name: ethanol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ethanol, CH3-CH2-OH, a colorless, water-miscible, flammable liquid produced by alcoholic fermentation." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ethanol anabolism" EXACT [] synonym: "ethanol biosynthesis" EXACT [] synonym: "ethanol formation" EXACT [] synonym: "ethanol synthesis" EXACT [] is_a: GO:0006067 ! ethanol metabolic process is_a: GO:0034309 ! monohydric alcohol biosynthetic process [Term] id: GO:0006116 name: NADH oxidation namespace: biological_process def: "A metabolic process that results in the oxidation of reduced nicotinamide adenine dinucleotide, NADH, to the oxidized form, NAD." [GOC:ai] subset: gosubset_prok synonym: "NAD (reduced) dehydrogenation" EXACT [] synonym: "NAD (reduced) oxidation" EXACT [] synonym: "NADH dehydrogenation" EXACT [] synonym: "reduced NAD dehydrogenation" EXACT [] synonym: "reduced NAD oxidation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide dehydrogenation" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide oxidation" EXACT [] is_a: GO:0006734 ! NADH metabolic process [Term] id: GO:0006117 name: acetaldehyde metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetaldehyde, a colorless, flammable liquid intermediate in the metabolism of alcohol." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "acetaldehyde metabolism" EXACT [] synonym: "ethanal metabolic process" EXACT [] synonym: "ethanal metabolism" EXACT [] is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0006118 name: electron transport namespace: biological_process def: "OBSOLETE. The transport of electrons from an electron donor to an electron acceptor." [http://cancerweb.ncl.ac.uk/] comment: This term was made obsolete because it describes a molecular function. synonym: "6-phosphofructokinase reduction" RELATED [] synonym: "dihydrobiopterin reduction" RELATED [] synonym: "dihydrolipoamide reduction" RELATED [] synonym: "dihydrolipoylprotein reduction" RELATED [] synonym: "dihydropteridine reduction" RELATED [] synonym: "electron transfer" EXACT [] synonym: "other pathways of electron transport" RELATED [] synonym: "oxidized glutathione reduction" RELATED [] synonym: "protein-disulfide reduction" RELATED [] is_obsolete: true replaced_by: GO:0055114 consider: GO:0016491 consider: GO:0022904 [Term] id: GO:0006119 name: oxidative phosphorylation namespace: biological_process def: "The phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0471331309 "Biochemical Pathways"] subset: goslim_pir subset: gosubset_prok synonym: "respiratory-chain phosphorylation" EXACT [] xref: Wikipedia:Oxidative_phosphorylation is_a: GO:0006091 ! generation of precursor metabolites and energy is_a: GO:0016310 ! phosphorylation [Term] id: GO:0006120 name: mitochondrial electron transport, NADH to ubiquinone namespace: biological_process def: "The transfer of electrons from NADH to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex I." [ISBN:0716731363] synonym: "complex I (NADH to ubiquinone)" RELATED [] synonym: "oxidative phosphorylation, NADH to ubiquinone" EXACT [] xref: Reactome:163217 "NADH enters the respiratory chain at Complex I" xref: Reactome:555607 "NADH enters the respiratory chain at Complex I" xref: Reactome:581589 "NADH enters the respiratory chain at Complex I" xref: Reactome:604133 "NADH enters the respiratory chain at Complex I" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006121 name: mitochondrial electron transport, succinate to ubiquinone namespace: biological_process def: "The transfer of electrons from succinate to ubiquinone that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex II." [ISBN:0716731363] synonym: "complex II (succinate to ubiquinone)" RELATED [] synonym: "mitochondrial electron transport, succinate to coenzyme Q" EXACT [] synonym: "oxidative phosphorylation, succinate to ubiquinone" EXACT [] xref: Reactome:163213 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:165642 "Transfer of electrons through the bovine succinate dehydrogenase complex" xref: Reactome:561702 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:587327 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:608316 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:632830 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:644869 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:655260 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:660705 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:666473 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:672531 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:678316 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:683228 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:700890 "Transfer of electrons through the succinate dehydrogenase complex" xref: Reactome:727662 "Transfer of electrons through the succinate dehydrogenase complex" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006122 name: mitochondrial electron transport, ubiquinol to cytochrome c namespace: biological_process def: "The transfer of electrons from ubiquinol to cytochrome c that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex III." [ISBN:0716731363] synonym: "complex III (ubiquinone to cytochrome c)" RELATED [] xref: Reactome:164651 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:548955 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:575733 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:599009 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:622398 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:640268 "Electron transfer from ubiquinol to cytochrome c of complex III" xref: Reactome:650952 "Electron transfer from ubiquinol to cytochrome c of complex III" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006123 name: mitochondrial electron transport, cytochrome c to oxygen namespace: biological_process def: "The transfer of electrons from cytochrome c to oxygen that occurs during oxidative phosphorylation, mediated by the multisubunit enzyme known as complex IV." [ISBN:0716731363] synonym: "complex IV (reduction of O2)" RELATED [] xref: Reactome:163214 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:548927 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:575700 "Electron transfer from reduced cytochrome c to molecular oxygen" xref: Reactome:598982 "Electron transfer from reduced cytochrome c to molecular oxygen" is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0042775 ! mitochondrial ATP synthesis coupled electron transport [Term] id: GO:0006124 name: ferredoxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ferredoxin, any simple, nonenzymatic iron-sulfur protein that is characterized by having equal numbers of atoms of iron and labile sulfur. Iron and sulfur atoms are present in one or two clusters of two or four atoms of each." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ferredoxin metabolism" EXACT [] is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006125 name: thioredoxin pathway namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is not clear what it is intended to represent. synonym: "thioredoxin reduction" NARROW [] xref: MetaCyc:THIOREDOX-PWY is_obsolete: true consider: GO:0045454 [Term] id: GO:0006126 name: other pathways of electron transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true replaced_by: GO:0022900 [Term] id: GO:0006127 name: glycerophosphate shuttle namespace: biological_process def: "The process of transferring reducing equivalents from the cytosol into the mitochondria; NADH is used to synthesise glycerol 3-phosphate in the cytosol; this compound is then transported into the mitochondria where it is converted to dihydroxyacetone phosphate (DHAP) using FAD; DHAP then returns to the cytosol to complete the cycle." [GOC:jl, GOC:mtg_electron_transport, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok is_a: GO:0006839 ! mitochondrial transport relationship: part_of GO:0022904 ! respiratory electron transport chain [Term] id: GO:0006128 name: oxidized glutathione reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string represents a molecular function and not a biological pathway. is_obsolete: true consider: GO:0004362 consider: GO:0006749 consider: GO:0022900 [Term] id: GO:0006129 name: protein-disulfide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. synonym: "protein-disulphide reduction" EXACT [] is_obsolete: true consider: GO:0019153 consider: GO:0022900 [Term] id: GO:0006130 name: 6-phosphofructokinase reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string was ambiguous and the term may represent a molecular function. is_obsolete: true consider: GO:0003872 consider: GO:0022900 [Term] id: GO:0006131 name: dihydrolipoamide reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004148 consider: GO:0022900 consider: GO:0051068 [Term] id: GO:0006132 name: dihydrolipoylprotein reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004148 consider: GO:0022900 [Term] id: GO:0006133 name: 5,10-methylenetetrahydrofolate oxidation namespace: biological_process def: "OBSOLETE." [GOC:mtg_electron_transport] comment: This term was made obsolete because it is defined as a function term and is in the process ontology. is_obsolete: true consider: GO:0004487 consider: GO:0004488 consider: GO:0004489 consider: GO:0033738 [Term] id: GO:0006134 name: dihydrobiopterin reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0022900 consider: GO:0047040 consider: GO:0051066 [Term] id: GO:0006135 name: dihydropteridine reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004155 consider: GO:0022900 consider: GO:0051067 [Term] id: GO:0006139 name: nucleobase, nucleoside, nucleotide and nucleic acid metabolic process namespace: biological_process alt_id: GO:0055134 def: "Any cellular metabolic process involving nucleobases, nucleosides, nucleotides and nucleic acids." [GOC:ai] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolic process" EXACT [] synonym: "cellular nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] synonym: "nucleobase, nucleoside, nucleotide and nucleic acid metabolism" EXACT [] is_a: GO:0034641 ! cellular nitrogen compound metabolic process is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0006140 name: regulation of nucleotide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleotides." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleotide metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009117 ! nucleotide metabolic process relationship: regulates GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006141 name: regulation of purine base metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving purines." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of purine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006144 ! purine base metabolic process relationship: regulates GO:0006144 ! purine base metabolic process [Term] id: GO:0006142 name: regulation of pyrimidine base metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pyrimidines." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of pyrimidine base metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006206 ! pyrimidine base metabolic process relationship: regulates GO:0006206 ! pyrimidine base metabolic process [Term] id: GO:0006143 name: purine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0006144 consider: GO:0006163 consider: GO:0042278 [Term] id: GO:0006144 name: purine base metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] subset: gosubset_prok synonym: "purine base metabolism" EXACT [] synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] xref: Reactome:562516 "Purine metabolism" xref: Reactome:588142 "Purine metabolism" xref: Reactome:608910 "Purine metabolism" xref: Reactome:633592 "Purine metabolism" xref: Reactome:645224 "Purine metabolism" xref: Reactome:655600 "Purine metabolism" xref: Reactome:660888 "Purine metabolism" xref: Reactome:666671 "Purine metabolism" xref: Reactome:672763 "Purine metabolism" xref: Reactome:678495 "Purine metabolism" xref: Reactome:683444 "Purine metabolism" xref: Reactome:689640 "Purine metabolism" xref: Reactome:701375 "Purine metabolism" xref: Reactome:715946 "Purine metabolism" xref: Reactome:720638 "Purine metabolism" xref: Reactome:727896 "Purine metabolism" xref: Reactome:730887 "Purine metabolism" xref: Reactome:733019 "Purine metabolism" xref: Reactome:733857 "Purine metabolism" xref: Reactome:735516 "Purine metabolism" xref: Reactome:736512 "Purine metabolism" xref: Reactome:738420 "Purine metabolism" xref: Reactome:73847 "Purine metabolism" is_a: GO:0009112 ! nucleobase metabolic process [Term] id: GO:0006145 name: purine base catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators] subset: gosubset_prok synonym: "purine base breakdown" EXACT [] synonym: "purine base catabolism" EXACT [] synonym: "purine base degradation" EXACT [] is_a: GO:0006144 ! purine base metabolic process is_a: GO:0046113 ! nucleobase catabolic process [Term] id: GO:0006146 name: adenine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenine, 6-aminopurine, one of the 5 main bases found in nucleic acids and a component of numerous important derivatives of its corresponding ribonucleoside, adenosine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "adenine breakdown" EXACT [] synonym: "adenine catabolism" EXACT [] synonym: "adenine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046083 ! adenine metabolic process [Term] id: GO:0006147 name: guanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important." [GOC:go_curators] subset: gosubset_prok synonym: "guanine breakdown" EXACT [] synonym: "guanine catabolism" EXACT [] synonym: "guanine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006148 name: inosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of inosine, hypoxanthine riboside, a nucleoside found free but not in combination in nucleic acids except in the anticodons of some tRNAs." [GOC:go_curators] subset: gosubset_prok synonym: "inosine breakdown" EXACT [] synonym: "inosine catabolism" EXACT [] synonym: "inosine degradation" EXACT [] is_a: GO:0046102 ! inosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006149 name: deoxyinosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyinosine, hypoxanthine deoxyriboside." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyinosine breakdown" EXACT [] synonym: "deoxyinosine catabolism" EXACT [] synonym: "deoxyinosine degradation" EXACT [] is_a: GO:0046094 ! deoxyinosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006150 name: hypoxanthine oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine to xanthine and thence to uric acid." [GOC:mah, PMID:3196295] subset: gosubset_prok is_a: GO:0009114 ! hypoxanthine catabolic process [Term] id: GO:0006151 name: xanthine oxidation namespace: biological_process def: "The oxidation of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:jl] subset: gosubset_prok is_a: GO:0009115 ! xanthine catabolic process [Term] id: GO:0006152 name: purine nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside, one of a family of organic molecules consisting of a purine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:go_curators] subset: gosubset_prok synonym: "purine nucleoside breakdown" EXACT [] synonym: "purine nucleoside catabolism" EXACT [] synonym: "purine nucleoside degradation" EXACT [] is_a: GO:0009164 ! nucleoside catabolic process is_a: GO:0042278 ! purine nucleoside metabolic process [Term] id: GO:0006153 name: purine nucleosidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0008477 [Term] id: GO:0006154 name: adenosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of adenosine, adenine riboside, a ribonucleoside found widely distributed in cells of every type as the free nucleoside and in combination in nucleic acids and various nucleoside coenzymes." [GOC:go_curators] subset: gosubset_prok synonym: "adenosine breakdown" EXACT [] synonym: "adenosine catabolism" EXACT [] synonym: "adenosine degradation" EXACT [] is_a: GO:0046085 ! adenosine metabolic process is_a: GO:0046130 ! purine ribonucleoside catabolic process [Term] id: GO:0006155 name: adenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004000 [Term] id: GO:0006156 name: adenosine phosphorolysis namespace: biological_process subset: gosubset_prok is_a: GO:0006154 ! adenosine catabolic process [Term] id: GO:0006157 name: deoxyadenosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyadenosine, 2-deoxyribosyladenine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyadenosine breakdown" EXACT [] synonym: "deoxyadenosine catabolism" EXACT [] synonym: "deoxyadenosine degradation" EXACT [] is_a: GO:0046090 ! deoxyadenosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006158 name: deoxyadenosine deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0046936 [Term] id: GO:0006159 name: deoxyadenosine phosphorolysis namespace: biological_process subset: gosubset_prok is_a: GO:0006157 ! deoxyadenosine catabolic process [Term] id: GO:0006160 name: guanosine phosphorolysis namespace: biological_process subset: gosubset_prok is_a: GO:0008617 ! guanosine metabolic process [Term] id: GO:0006161 name: deoxyguanosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyguanosine, a nucleoside consisting of the base guanine and the sugar deoxyribose." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "deoxyguanosine breakdown" EXACT [] synonym: "deoxyguanosine catabolism" EXACT [] synonym: "deoxyguanosine degradation" EXACT [] is_a: GO:0042453 ! deoxyguanosine metabolic process is_a: GO:0046124 ! purine deoxyribonucleoside catabolic process [Term] id: GO:0006162 name: purine/pyrimidine nucleoside diphosphate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004748 [Term] id: GO:0006163 name: purine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine metabolic process" NARROW [] synonym: "purine metabolism" NARROW [] synonym: "purine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006164 name: purine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleotide anabolism" EXACT [] synonym: "purine nucleotide biosynthesis" EXACT [] synonym: "purine nucleotide formation" EXACT [] synonym: "purine nucleotide synthesis" EXACT [] xref: MetaCyc:DENOVOPURINE2-PWY is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0006165 name: nucleoside diphosphate phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a nucleoside diphosphate to produce a nucleoside triphosphate." [GOC:ai] subset: gosubset_prok is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0046939 ! nucleotide phosphorylation [Term] id: GO:0006166 name: purine ribonucleoside salvage namespace: biological_process def: "Any process which produces a purine nucleoside from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok xref: MetaCyc:P121-PWY is_a: GO:0043101 ! purine salvage is_a: GO:0043174 ! nucleoside salvage is_a: GO:0046129 ! purine ribonucleoside biosynthetic process [Term] id: GO:0006167 name: AMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of AMP, adenosine monophosphate." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "AMP anabolism" EXACT [] synonym: "AMP biosynthesis" EXACT [] synonym: "AMP formation" EXACT [] synonym: "AMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006168 name: adenine salvage namespace: biological_process def: "Any process that generates adenine, 6-aminopurine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine salvage pathway" EXACT [] synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine base salvage is_a: GO:0046084 ! adenine biosynthetic process [Term] id: GO:0006169 name: adenosine salvage namespace: biological_process def: "Any process that generates adenosine, adenine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine, hypoxanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046086 ! adenosine biosynthetic process [Term] id: GO:0006170 name: dAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dAMP, deoxyadenosine monophosphate (2'-deoxyadenosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dAMP anabolism" EXACT [] synonym: "dAMP biosynthesis" EXACT [] synonym: "dAMP formation" EXACT [] synonym: "dAMP synthesis" EXACT [] is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046053 ! dAMP metabolic process [Term] id: GO:0006171 name: cAMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP biosynthesis" EXACT [] synonym: "3',5' cAMP biosynthetic process" EXACT [] synonym: "3',5'-cAMP biosynthesis" EXACT [] synonym: "3',5'-cAMP biosynthetic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthesis" EXACT [] synonym: "adenosine 3',5'-cyclophosphate biosynthetic process" EXACT [] synonym: "cAMP anabolism" EXACT [] synonym: "cAMP biosynthesis" EXACT [] synonym: "cAMP formation" EXACT [] synonym: "cAMP synthesis" EXACT [] synonym: "cyclic AMP biosynthesis" EXACT [] synonym: "cyclic AMP biosynthetic process" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006172 name: ADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ADP, adenosine 5'-diphosphate." [GOC:ai] subset: gosubset_prok synonym: "ADP anabolism" EXACT [] synonym: "ADP biosynthesis" EXACT [] synonym: "ADP formation" EXACT [] synonym: "ADP synthesis" EXACT [] is_a: GO:0009180 ! purine ribonucleoside diphosphate biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006173 name: dADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dADP, deoxyadenosine diphosphate (2'-deoxyadenosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dADP anabolism" EXACT [] synonym: "dADP biosynthesis" EXACT [] synonym: "dADP formation" EXACT [] synonym: "dADP synthesis" EXACT [] is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006174 name: dADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dADP, deoxyadenosine diphosphate, to produce dATP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046056 ! dADP metabolic process [Term] id: GO:0006175 name: dATP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dATP anabolism" EXACT [] synonym: "dATP biosynthesis" EXACT [] synonym: "dATP formation" EXACT [] synonym: "dATP synthesis" EXACT [] is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046060 ! dATP metabolic process [Term] id: GO:0006176 name: dATP biosynthetic process from ADP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dATP, deoxyadenosine triphosphate (2'-deoxyadenosine 5'-triphosphate) from other compounds, including ADP, adenosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dATP anabolism from ADP" EXACT [] synonym: "dATP formation from ADP" EXACT [] synonym: "dATP synthesis from ADP" EXACT [] is_a: GO:0006175 ! dATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006177 name: GMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GMP, guanosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP anabolism" EXACT [] synonym: "GMP biosynthesis" EXACT [] synonym: "GMP formation" EXACT [] synonym: "GMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046037 ! GMP metabolic process [Term] id: GO:0006178 name: guanine salvage namespace: biological_process def: "Any process that generates guanine, 2-amino-6-hydroxypurine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0043096 ! purine base salvage is_a: GO:0046099 ! guanine biosynthetic process [Term] id: GO:0006179 name: guanosine salvage namespace: biological_process def: "Any process that generates guanosine, guanine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "guanine, xanthine and their nucleoside salvage" BROAD [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046114 ! guanosine biosynthetic process [Term] id: GO:0006180 name: deoxyguanosine salvage namespace: biological_process def: "Any process that generates deoxyguanosine from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043098 ! purine deoxyribonucleoside salvage [Term] id: GO:0006181 name: dGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGMP, deoxyguanosine monophosphate (2'-deoxyguanosine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGMP anabolism" EXACT [] synonym: "dGMP biosynthesis" EXACT [] synonym: "dGMP formation" EXACT [] synonym: "dGMP synthesis" EXACT [] is_a: GO:0009171 ! purine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046054 ! dGMP metabolic process [Term] id: GO:0006182 name: cGMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cyclic GMP, guanosine 3',5'-phosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cGMP anabolism" EXACT [] synonym: "cGMP biosynthesis" EXACT [] synonym: "cGMP formation" EXACT [] synonym: "cGMP synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009190 ! cyclic nucleotide biosynthetic process is_a: GO:0046068 ! cGMP metabolic process [Term] id: GO:0006183 name: GTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GTP anabolism" EXACT [] synonym: "GTP biosynthesis" EXACT [] synonym: "GTP formation" EXACT [] synonym: "GTP synthesis" EXACT [] is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046039 ! GTP metabolic process [Term] id: GO:0006184 name: GTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of GTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GTP breakdown" EXACT [] synonym: "GTP catabolism" EXACT [] synonym: "GTP degradation" EXACT [] synonym: "GTP hydrolysis" NARROW [] is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046039 ! GTP metabolic process [Term] id: GO:0006185 name: dGDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGDP, deoxyguanosine diphosphate, (2'-deoxyguanosine 5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGDP anabolism" EXACT [] synonym: "dGDP biosynthesis" EXACT [] synonym: "dGDP formation" EXACT [] synonym: "dGDP synthesis" EXACT [] is_a: GO:0009183 ! purine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006186 name: dGDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dGDP, deoxyguanosine diphosphate, to produce dGTP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046066 ! dGDP metabolic process [Term] id: GO:0006187 name: dGTP biosynthetic process from dGDP namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dGTP, deoxyguanosine triphosphate (2'-deoxyguanosine 5'-triphosphate) from other compounds, including gGDP, deoxyguanosine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGTP anabolism from dGDP" EXACT [] synonym: "dGTP formation from dGDP" EXACT [] synonym: "dGTP synthesis from dGDP" EXACT [] is_a: GO:0046066 ! dGDP metabolic process is_a: GO:0046071 ! dGTP biosynthetic process [Term] id: GO:0006188 name: IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IMP anabolism" EXACT [] synonym: "IMP biosynthesis" EXACT [] synonym: "IMP formation" EXACT [] synonym: "IMP synthesis" EXACT [] is_a: GO:0009168 ! purine ribonucleoside monophosphate biosynthetic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006189 name: 'de novo' IMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate." [GOC:mah, ISBN:0716720094] subset: gosubset_prok synonym: "'de novo' IMP anabolism" EXACT [] synonym: "'de novo' IMP biosynthesis" EXACT [] synonym: "'de novo' IMP formation" EXACT [] synonym: "'de novo' IMP synthesis" EXACT [] synonym: "'de novo' purine biosynthesis" BROAD [] synonym: "'de novo' purine biosynthetic process" BROAD [] is_a: GO:0006188 ! IMP biosynthetic process [Term] id: GO:0006190 name: inosine salvage namespace: biological_process def: "Any process that generates inosine, hypoxanthine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "adenine, hypoxanthine and their nucleoside salvage" RELATED [] synonym: "guanine, xanthine and their nucleoside salvage" RELATED [] is_a: GO:0006166 ! purine ribonucleoside salvage is_a: GO:0046103 ! inosine biosynthetic process [Term] id: GO:0006191 name: deoxyinosine salvage namespace: biological_process def: "Any process that generates deoxyinosine from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043098 ! purine deoxyribonucleoside salvage is_a: GO:0046095 ! deoxyinosine biosynthetic process [Term] id: GO:0006192 name: IDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into IDP, inosine (5'-)diphosphate, to produce ITP." [GOC:ai] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046707 ! IDP metabolic process [Term] id: GO:0006193 name: ITP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ITP, inosine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ITP breakdown" EXACT [] synonym: "ITP catabolism" EXACT [] synonym: "ITP degradation" EXACT [] synonym: "ITP hydrolysis" EXACT [] is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046041 ! ITP metabolic process [Term] id: GO:0006194 name: dIDP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into dIDP, deoxyinosine diphosphate, to produce dITP." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0009216 ! purine deoxyribonucleoside triphosphate biosynthetic process [Term] id: GO:0006195 name: purine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleotide breakdown" EXACT [] synonym: "purine nucleotide catabolism" EXACT [] synonym: "purine nucleotide degradation" EXACT [] xref: Reactome:562533 "Purine catabolism" xref: Reactome:588159 "Purine catabolism" xref: Reactome:608927 "Purine catabolism" xref: Reactome:633609 "Purine catabolism" xref: Reactome:645239 "Purine catabolism" xref: Reactome:655614 "Purine catabolism" xref: Reactome:661056 "Purine catabolism" xref: Reactome:666683 "Purine catabolism" xref: Reactome:672942 "Purine catabolism" xref: Reactome:678500 "Purine catabolism" xref: Reactome:683452 "Purine catabolism" xref: Reactome:689648 "Purine catabolism" xref: Reactome:701390 "Purine catabolism" xref: Reactome:715961 "Purine catabolism" xref: Reactome:720843 "Purine catabolism" xref: Reactome:727910 "Purine catabolism" xref: Reactome:733110 "Purine catabolism" xref: Reactome:733920 "Purine catabolism" xref: Reactome:735519 "Purine catabolism" xref: Reactome:736561 "Purine catabolism" xref: Reactome:738432 "Purine catabolism" xref: Reactome:74259 "Purine catabolism" is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006196 name: AMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of AMP, adenosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "AMP breakdown" EXACT [] synonym: "AMP catabolism" EXACT [] synonym: "AMP degradation" EXACT [] is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046033 ! AMP metabolic process [Term] id: GO:0006197 name: adenylate deaminase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0003876 [Term] id: GO:0006198 name: cAMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "3',5' cAMP catabolic process" EXACT [] synonym: "3',5' cAMP catabolism" EXACT [] synonym: "3',5'-cAMP catabolic process" EXACT [] synonym: "3',5'-cAMP catabolism" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolic process" EXACT [] synonym: "adenosine 3',5'-cyclophosphate catabolism" EXACT [] synonym: "cAMP breakdown" EXACT [] synonym: "cAMP catabolism" EXACT [] synonym: "cAMP degradation" EXACT [] synonym: "cyclic AMP catabolic process" EXACT [] synonym: "cyclic AMP catabolism" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009214 ! cyclic nucleotide catabolic process is_a: GO:0046058 ! cAMP metabolic process [Term] id: GO:0006199 name: ADP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051061 [Term] id: GO:0006200 name: ATP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:ai] subset: gosubset_prok synonym: "ATP breakdown" EXACT [] synonym: "ATP catabolism" EXACT [] synonym: "ATP degradation" EXACT [] synonym: "ATP hydrolysis" NARROW [] xref: Wikipedia:ATP_hydrolysis is_a: GO:0009207 ! purine ribonucleoside triphosphate catabolic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006201 name: GMP catabolic process to IMP namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP breakdown to IMP" EXACT [] synonym: "GMP degradation to IMP" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006202 name: GMP catabolic process to guanine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of guanosine monophosphate into other compounds, including guanine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GMP breakdown to guanine" EXACT [] synonym: "GMP degradation to guanine" EXACT [] is_a: GO:0046038 ! GMP catabolic process is_a: GO:0046098 ! guanine metabolic process [Term] id: GO:0006203 name: dGTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dGTP breakdown" EXACT [] synonym: "dGTP catabolism" EXACT [] synonym: "dGTP degradation" EXACT [] is_a: GO:0009217 ! purine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046070 ! dGTP metabolic process [Term] id: GO:0006204 name: IMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of IMP, inosine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IMP breakdown" EXACT [] synonym: "IMP catabolism" EXACT [] synonym: "IMP degradation" EXACT [] is_a: GO:0009169 ! purine ribonucleoside monophosphate catabolic process is_a: GO:0046040 ! IMP metabolic process [Term] id: GO:0006205 name: pyrimidine metabolic process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0006206 consider: GO:0006213 consider: GO:0006220 [Term] id: GO:0006206 name: pyrimidine base metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] subset: gosubset_prok synonym: "pyrimidine base metabolism" EXACT [] synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] xref: Reactome:562519 "Pyrimidine metabolism" xref: Reactome:588145 "Pyrimidine metabolism" xref: Reactome:608913 "Pyrimidine metabolism" xref: Reactome:633595 "Pyrimidine metabolism" xref: Reactome:645227 "Pyrimidine metabolism" xref: Reactome:655611 "Pyrimidine metabolism" xref: Reactome:660899 "Pyrimidine metabolism" xref: Reactome:666682 "Pyrimidine metabolism" xref: Reactome:672772 "Pyrimidine metabolism" xref: Reactome:678499 "Pyrimidine metabolism" xref: Reactome:683454 "Pyrimidine metabolism" xref: Reactome:689659 "Pyrimidine metabolism" xref: Reactome:701378 "Pyrimidine metabolism" xref: Reactome:715949 "Pyrimidine metabolism" xref: Reactome:720678 "Pyrimidine metabolism" xref: Reactome:727899 "Pyrimidine metabolism" xref: Reactome:730895 "Pyrimidine metabolism" xref: Reactome:733072 "Pyrimidine metabolism" xref: Reactome:733900 "Pyrimidine metabolism" xref: Reactome:735527 "Pyrimidine metabolism" xref: Reactome:736516 "Pyrimidine metabolism" xref: Reactome:738431 "Pyrimidine metabolism" xref: Reactome:73848 "Pyrimidine metabolism" is_a: GO:0009112 ! nucleobase metabolic process [Term] id: GO:0006207 name: 'de novo' pyrimidine base biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine bases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors." [GOC:mah, ISBN:0716720094] subset: gosubset_prok synonym: "'de novo' pyrimidine base anabolism" EXACT [] synonym: "'de novo' pyrimidine base biosynthesis" EXACT [] synonym: "'de novo' pyrimidine base formation" EXACT [] synonym: "'de novo' pyrimidine base synthesis" EXACT [] is_a: GO:0019856 ! pyrimidine base biosynthetic process [Term] id: GO:0006208 name: pyrimidine base catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine bases, 1,3-diazine, organic nitrogenous bases." [GOC:go_curators] subset: gosubset_prok synonym: "pyrimidine base breakdown" EXACT [] synonym: "pyrimidine base catabolism" EXACT [] synonym: "pyrimidine base degradation" EXACT [] is_a: GO:0006206 ! pyrimidine base metabolic process is_a: GO:0046113 ! nucleobase catabolic process [Term] id: GO:0006209 name: cytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytosine, 4-amino-2-hydroxypyrimidine, a pyrimidine derivative that is one of the five main bases found in nucleic acids; it occurs widely in cytidine derivatives." [GOC:go_curators] subset: gosubset_prok synonym: "cytosine breakdown" EXACT [] synonym: "cytosine catabolism" EXACT [] synonym: "cytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019858 ! cytosine metabolic process [Term] id: GO:0006210 name: thymine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thymine, 5-methyluracil, one of the two major pyrimidine bases present (as thymidine) in DNA but not found in RNA other than (as ribothymidine) in transfer RNA, where it is a minor base." [GOC:go_curators] subset: gosubset_prok synonym: "thymine breakdown" EXACT [] synonym: "thymine catabolism" EXACT [] synonym: "thymine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019859 ! thymine metabolic process [Term] id: GO:0006211 name: 5-methylcytosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 5-methylcytosine, a methylated base of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "5-methylcytosine breakdown" EXACT [] synonym: "5-methylcytosine catabolism" EXACT [] synonym: "5-methylcytosine degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019857 ! 5-methylcytosine metabolic process [Term] id: GO:0006212 name: uracil catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uracil, 2,4-dioxopyrimidine, one of the pyrimidine bases occurring in RNA, but not in DNA." [GOC:go_curators] subset: gosubset_prok synonym: "uracil breakdown" EXACT [] synonym: "uracil catabolism" EXACT [] synonym: "uracil degradation" EXACT [] is_a: GO:0006208 ! pyrimidine base catabolic process is_a: GO:0019860 ! uracil metabolic process [Term] id: GO:0006213 name: pyrimidine nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any pyrimidine nucleoside, one of a family of organic molecules consisting of a pyrimidine base covalently bonded to ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0006214 name: thymidine catabolic process namespace: biological_process alt_id: GO:0006215 def: "The chemical reactions and pathways resulting in the breakdown of thymidine, deoxyribosylthymine thymine 2-deoxyriboside, a deoxynucleoside very widely distributed but occurring almost entirely as phosphoric esters in deoxynucleotides and deoxyribonucleic acid, DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyribosylthymine catabolic process" EXACT [] synonym: "deoxyribosylthymine catabolism" EXACT [] synonym: "thymidine breakdown" EXACT [] synonym: "thymidine catabolism" EXACT [] synonym: "thymidine degradation" EXACT [] is_a: GO:0046104 ! thymidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006216 name: cytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytidine, cytosine riboside, a widely distributed nucleoside." [GOC:ai] subset: gosubset_prok synonym: "cytidine breakdown" EXACT [] synonym: "cytidine catabolism" EXACT [] synonym: "cytidine degradation" EXACT [] is_a: GO:0046087 ! cytidine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006217 name: deoxycytidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxycytidine, 2-deoxyribosylcytosine, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxycytidine breakdown" EXACT [] synonym: "deoxycytidine catabolism" EXACT [] synonym: "deoxycytidine degradation" EXACT [] is_a: GO:0046092 ! deoxycytidine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006218 name: uridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of uridine, uracil riboside, a ribonucleoside very widely distributed but occurring almost entirely as phosphoric esters in ribonucleotides and ribonucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "uridine breakdown" EXACT [] synonym: "uridine catabolism" EXACT [] synonym: "uridine degradation" EXACT [] is_a: GO:0046108 ! uridine metabolic process is_a: GO:0046133 ! pyrimidine ribonucleoside catabolic process [Term] id: GO:0006219 name: deoxyuridine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of deoxyuridine, 2-deoxyribosyluracil, one of the four major nucleosides of DNA." [GOC:go_curators] subset: gosubset_prok synonym: "deoxyuridine breakdown" EXACT [] synonym: "deoxyuridine catabolism" EXACT [] synonym: "deoxyuridine degradation" EXACT [] is_a: GO:0046096 ! deoxyuridine metabolic process is_a: GO:0046127 ! pyrimidine deoxyribonucleoside catabolic process [Term] id: GO:0006220 name: pyrimidine nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine metabolic process" BROAD [] synonym: "pyrimidine metabolism" BROAD [] synonym: "pyrimidine nucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006221 name: pyrimidine nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleotide anabolism" EXACT [] synonym: "pyrimidine nucleotide biosynthesis" EXACT [] synonym: "pyrimidine nucleotide formation" EXACT [] synonym: "pyrimidine nucleotide synthesis" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0006222 name: UMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UMP anabolism" EXACT [] synonym: "UMP biosynthesis" EXACT [] synonym: "UMP formation" EXACT [] synonym: "UMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046049 ! UMP metabolic process [Term] id: GO:0006223 name: uracil salvage namespace: biological_process def: "Any process that generates uracil, 2,4-dioxopyrimidine, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0019860 ! uracil metabolic process is_a: GO:0043100 ! pyrimidine base salvage [Term] id: GO:0006224 name: uridine kinase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004849 [Term] id: GO:0006225 name: UDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UDP anabolism" EXACT [] synonym: "UDP biosynthesis" EXACT [] synonym: "UDP formation" EXACT [] synonym: "UDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006226 name: dUMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUMP, deoxyuridine monophosphate (2'-deoxyuridine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUMP anabolism" EXACT [] synonym: "dUMP biosynthesis" EXACT [] synonym: "dUMP formation" EXACT [] synonym: "dUMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046078 ! dUMP metabolic process [Term] id: GO:0006227 name: dUDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUDP, deoxyuridine diphosphate (2'-deoxy-5'-uridylyl phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUDP anabolism" EXACT [] synonym: "dUDP biosynthesis" EXACT [] synonym: "dUDP formation" EXACT [] synonym: "dUDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006228 name: UTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UTP, uridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UTP anabolism" EXACT [] synonym: "UTP biosynthesis" EXACT [] synonym: "UTP formation" EXACT [] synonym: "UTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046051 ! UTP metabolic process [Term] id: GO:0006229 name: dUTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dUTP, deoxyuridine (5'-)triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUTP anabolism" EXACT [] synonym: "dUTP biosynthesis" EXACT [] synonym: "dUTP formation" EXACT [] synonym: "dUTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046080 ! dUTP metabolic process [Term] id: GO:0006230 name: TMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TMP, ribosylthymine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TMP anabolism" EXACT [] synonym: "TMP biosynthesis" EXACT [] synonym: "TMP formation" EXACT [] synonym: "TMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046044 ! TMP metabolic process [Term] id: GO:0006231 name: dTMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTMP anabolism" EXACT [] synonym: "dTMP biosynthesis" EXACT [] synonym: "dTMP formation" EXACT [] synonym: "dTMP synthesis" EXACT [] is_a: GO:0009177 ! pyrimidine deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0046073 ! dTMP metabolic process [Term] id: GO:0006232 name: TDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TDP anabolism" EXACT [] synonym: "TDP biosynthesis" EXACT [] synonym: "TDP formation" EXACT [] synonym: "TDP synthesis" EXACT [] is_a: GO:0009194 ! pyrimidine ribonucleoside diphosphate biosynthetic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006233 name: dTDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTDP anabolism" EXACT [] synonym: "dTDP biosynthesis" EXACT [] synonym: "dTDP formation" EXACT [] synonym: "dTDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006234 name: TTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of TTP, ribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TTP anabolism" EXACT [] synonym: "TTP biosynthesis" EXACT [] synonym: "TTP formation" EXACT [] synonym: "TTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046046 ! TTP metabolic process [Term] id: GO:0006235 name: dTTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dTTP, deoxyribosylthymine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTTP anabolism" EXACT [] synonym: "dTTP biosynthesis" EXACT [] synonym: "dTTP formation" EXACT [] synonym: "dTTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046075 ! dTTP metabolic process [Term] id: GO:0006236 name: cytidine salvage namespace: biological_process def: "Any process that generates cytidine, cytosine riboside, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043097 ! pyrimidine nucleoside salvage is_a: GO:0046088 ! cytidine biosynthetic process [Term] id: GO:0006237 name: deoxycytidine salvage namespace: biological_process def: "Any process that generates deoxycytidine, 2-deoxyribosylcytosine, from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok is_a: GO:0043099 ! pyrimidine deoxyribonucleoside salvage is_a: GO:0046093 ! deoxycytidine biosynthetic process [Term] id: GO:0006238 name: CMP salvage namespace: biological_process def: "Any process that generates CMP, cytidine monophosphate, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "cytidine monophosphate salvage" EXACT [] is_a: GO:0009224 ! CMP biosynthetic process is_a: GO:0010138 ! pyrimidine ribonucleotide salvage [Term] id: GO:0006239 name: dCMP salvage namespace: biological_process def: "Any process that generates dCMP, deoxycytidine monophosphate from derivatives of it, without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "deoxycytidine monophosphate salvage" EXACT [] is_a: GO:0010139 ! pyrimidine deoxyribonucleotide salvage is_a: GO:0046064 ! dCMP biosynthetic process [Term] id: GO:0006240 name: dCDP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCDP anabolism" EXACT [] synonym: "dCDP biosynthesis" EXACT [] synonym: "dCDP formation" EXACT [] synonym: "dCDP synthesis" EXACT [] is_a: GO:0009197 ! pyrimidine deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006241 name: CTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CTP anabolism" EXACT [] synonym: "CTP biosynthesis" EXACT [] synonym: "CTP formation" EXACT [] synonym: "CTP synthesis" EXACT [] is_a: GO:0009209 ! pyrimidine ribonucleoside triphosphate biosynthetic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006242 name: dCTP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCTP anabolism" EXACT [] synonym: "dCTP biosynthesis" EXACT [] synonym: "dCTP formation" EXACT [] synonym: "dCTP synthesis" EXACT [] is_a: GO:0009212 ! pyrimidine deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006243 name: CTP deamination namespace: biological_process subset: gosubset_prok is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006244 name: pyrimidine nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine nucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose or ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleotide breakdown" EXACT [] synonym: "pyrimidine nucleotide catabolism" EXACT [] synonym: "pyrimidine nucleotide degradation" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006245 name: TDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of TDP, ribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TDP breakdown" EXACT [] synonym: "TDP catabolism" EXACT [] synonym: "TDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0046043 ! TDP metabolic process [Term] id: GO:0006246 name: dTDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dTDP, deoxyribosylthymine diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dTDP breakdown" EXACT [] synonym: "dTDP catabolism" EXACT [] synonym: "dTDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046072 ! dTDP metabolic process [Term] id: GO:0006247 name: TTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051064 [Term] id: GO:0006248 name: CMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CMP breakdown" EXACT [] synonym: "CMP catabolism" EXACT [] synonym: "CMP degradation" EXACT [] is_a: GO:0009175 ! pyrimidine ribonucleoside monophosphate catabolic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0006249 name: dCMP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCMP, deoxycytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCMP breakdown" EXACT [] synonym: "dCMP catabolism" EXACT [] synonym: "dCMP degradation" EXACT [] is_a: GO:0009178 ! pyrimidine deoxyribonucleoside monophosphate catabolic process is_a: GO:0046063 ! dCMP metabolic process [Term] id: GO:0006250 name: CDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051063 [Term] id: GO:0006251 name: dCDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCDP, deoxycytidine 5'-diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCDP breakdown" EXACT [] synonym: "dCDP catabolism" EXACT [] synonym: "dCDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046062 ! dCDP metabolic process [Term] id: GO:0006252 name: CTP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051065 [Term] id: GO:0006253 name: dCTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dCTP, deoxycytidine triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dCTP breakdown" EXACT [] synonym: "dCTP catabolism" EXACT [] synonym: "dCTP degradation" EXACT [] is_a: GO:0009213 ! pyrimidine deoxyribonucleoside triphosphate catabolic process is_a: GO:0046065 ! dCTP metabolic process [Term] id: GO:0006254 name: CTP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of CTP, cytidine 5'-triphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CTP breakdown" EXACT [] synonym: "CTP catabolism" EXACT [] synonym: "CTP degradation" EXACT [] synonym: "CTP hydrolysis" EXACT [] is_a: GO:0009210 ! pyrimidine ribonucleoside triphosphate catabolic process is_a: GO:0046036 ! CTP metabolic process [Term] id: GO:0006255 name: UDP reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0051062 [Term] id: GO:0006256 name: UDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP, uridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "UDP breakdown" EXACT [] synonym: "UDP catabolism" EXACT [] synonym: "UDP degradation" EXACT [] is_a: GO:0009195 ! pyrimidine ribonucleoside diphosphate catabolic process is_a: GO:0046048 ! UDP metabolic process [Term] id: GO:0006257 name: dUDP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of dUDP, deoxyuridine (5'-)diphosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dUDP breakdown" EXACT [] synonym: "dUDP catabolism" EXACT [] synonym: "dUDP degradation" EXACT [] is_a: GO:0009198 ! pyrimidine deoxyribonucleoside diphosphate catabolic process is_a: GO:0046077 ! dUDP metabolic process [Term] id: GO:0006258 name: UDP-glucose catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of UDP-glucose, uridinediphosphoglucose, a substance composed of glucose in glycosidic linkage with uridine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "UDP-glucose breakdown" EXACT [] synonym: "UDP-glucose catabolism" EXACT [] synonym: "UDP-glucose degradation" EXACT [] is_a: GO:0006011 ! UDP-glucose metabolic process is_a: GO:0009227 ! nucleotide-sugar catabolic process is_a: GO:0044275 ! cellular carbohydrate catabolic process [Term] id: GO:0006259 name: DNA metabolic process namespace: biological_process alt_id: GO:0055132 def: "Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cellular DNA metabolism" EXACT [] synonym: "DNA metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0090304 ! nucleic acid metabolic process [Term] id: GO:0006260 name: DNA replication namespace: biological_process alt_id: GO:0055133 def: "The cellular metabolic process whereby new strands of DNA are synthesized. The template for replication can either be an existing DNA molecule or RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process terms 'DNA-dependent DNA replication ; GO:0006261' and 'RNA-dependent DNA replication ; GO:0006278'. subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "DNA biosynthesis" RELATED [] synonym: "DNA biosynthetic process" RELATED [] synonym: "DNA synthesis" RELATED [] xref: Reactome:176101 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:176116 "Recruitment and activation of Chk1" xref: Reactome:176175 "Stalling of DNA replication fork and RPA binding" xref: Reactome:176187 "Activation of ATR in response to replication stress" xref: Reactome:176250 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:176264 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:176298 "Activation of claspin" xref: Reactome:176318 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:539624 "Activation of claspin" xref: Reactome:543879 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:554696 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:559584 "Recruitment and activation of Chk1" xref: Reactome:559733 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:559766 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:560829 "Stalling of DNA replication fork and RPA binding" xref: Reactome:562757 "Activation of ATR in response to replication stress" xref: Reactome:580487 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:585496 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:585525 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:586578 "Stalling of DNA replication fork and RPA binding" xref: Reactome:588884 "Activation of ATR in response to replication stress" xref: Reactome:591405 "Activation of claspin" xref: Reactome:595080 "Binding of ATR-ATRIP to the RPA-ssDNA complex" xref: Reactome:603307 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:606663 "Recruitment and activation of Chk1" xref: Reactome:606740 "Recruitment of Rad17-RFC complex to DNA" xref: Reactome:606762 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:607579 "Stalling of DNA replication fork and RPA binding" xref: Reactome:609113 "Activation of ATR in response to replication stress" xref: Reactome:612899 "Activation of claspin" xref: Reactome:627290 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:630930 "Recruitment and activation of Chk1" xref: Reactome:633809 "Activation of ATR in response to replication stress" xref: Reactome:642014 "Loading of claspin onto DNA during replication origin firing" xref: Reactome:643959 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:645776 "Activation of ATR in response to replication stress" xref: Reactome:654425 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:656152 "Activation of ATR in response to replication stress" xref: Reactome:661296 "Activation of ATR in response to replication stress" xref: Reactome:667074 "Activation of ATR in response to replication stress" xref: Reactome:672160 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:673223 "Activation of ATR in response to replication stress" xref: Reactome:677963 "Recruitment of the Rad9-Hus1-Rad1 complex to DNA" xref: Reactome:678907 "Activation of ATR in response to replication stress" xref: Wikipedia:DNA_replication is_a: GO:0006259 ! DNA metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0006261 name: DNA-dependent DNA replication namespace: biological_process alt_id: GO:0006262 alt_id: GO:0006263 def: "The process whereby new strands of DNA are synthesized, using parental DNA as a template for the DNA-dependent DNA polymerases that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0006264 name: mitochondrial DNA replication namespace: biological_process def: "The process whereby new strands of DNA are synthesized in the mitochondrion." [GOC:ai] synonym: "mitochondrial DNA synthesis" RELATED [] synonym: "mtDNA replication" EXACT [] synonym: "mtDNA synthesis" RELATED [] synonym: "replication of mitochondrial DNA" EXACT [] is_a: GO:0006261 ! DNA-dependent DNA replication is_a: GO:0032042 ! mitochondrial DNA metabolic process [Term] id: GO:0006265 name: DNA topological change namespace: biological_process def: "The process by which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number." [ISBN:071673706X, ISBN:0935702490] comment: Note that the synonym 'DNA underwinding' should not be confused with 'DNA unwinding ; GO:0006268', which refers to DNA strand separation, and is a type of geometric change. GO:0006265 refers to alteration of the superhelical density of double-stranded DNA. Note that DNA topological change and DNA geometric change (GO:0032392) are distinct, but are usually coupled in vivo. subset: gosubset_prok synonym: "DNA underwinding" NARROW [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006266 name: DNA ligation namespace: biological_process def: "The re-formation of a broken phosphodiester bond in the DNA backbone, carried out by DNA ligase." [ISBN:0815316194] subset: goslim_pir subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006267 name: pre-replicative complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at eukaryotic DNA replication origins during late M phase; its presence is required for replication initiation." [GOC:mah] synonym: "pre-replicative complex formation" EXACT [] is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006268 name: DNA unwinding involved in replication namespace: biological_process def: "The process by which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication." [ISBN:071673706X, ISBN:0815316194] comment: Note that this term refers to a geometric change in DNA conformation, and should not be confused with 'DNA topological change ; GO:0006265'. subset: gosubset_prok synonym: "DNA unwinding during replication" RELATED [GOC:dph, GOC:tb] synonym: "DNA unwinding factor" RELATED [] is_a: GO:0032508 ! DNA duplex unwinding relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006269 name: DNA replication, synthesis of RNA primer namespace: biological_process def: "The synthesis of a short RNA polymer, usually 4-15 nucleotides long, using one strand of unwound DNA as a template; the RNA then serves as a primer from which DNA polymerases extend synthesis." [PMID:11395402] subset: gosubset_prok synonym: "replication priming" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0032774 ! RNA biosynthetic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006270 name: DNA-dependent DNA replication initiation namespace: biological_process def: "The process by which DNA replication is started; this involves the separation of a stretch of the DNA double helix, the recruitment of DNA polymerases and the initiation of polymerase action." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok xref: Reactome:563385 "DNA replication initiation" xref: Reactome:589005 "DNA replication initiation" xref: Reactome:634424 "DNA replication initiation" xref: Reactome:645888 "DNA replication initiation" xref: Reactome:656208 "DNA replication initiation" xref: Reactome:661338 "DNA replication initiation" xref: Reactome:667122 "DNA replication initiation" xref: Reactome:673263 "DNA replication initiation" xref: Reactome:678949 "DNA replication initiation" xref: Reactome:683869 "DNA replication initiation" xref: Reactome:68952 "DNA replication initiation" xref: Reactome:690123 "DNA replication initiation" xref: Reactome:701871 "DNA replication initiation" xref: Reactome:716445 "DNA replication initiation" xref: Reactome:720953 "DNA replication initiation" xref: Reactome:728403 "DNA replication initiation" xref: Reactome:731182 "DNA replication initiation" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006271 name: DNA strand elongation involved in DNA replication namespace: biological_process def: "The process by which a DNA strand is synthesized from template DNA during replication by the action of polymerases, which add nucleotides to the 3' end of the nascent DNA strand." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok synonym: "DNA replication elongation" EXACT [] synonym: "DNA strand elongation during DNA replication" RELATED [GOC:dph, GOC:tb] xref: Reactome:563192 "DNA strand elongation" xref: Reactome:588798 "DNA strand elongation" xref: Reactome:609583 "DNA strand elongation" xref: Reactome:634229 "DNA strand elongation" xref: Reactome:645719 "DNA strand elongation" xref: Reactome:656049 "DNA strand elongation" xref: Reactome:661224 "DNA strand elongation" xref: Reactome:667003 "DNA strand elongation" xref: Reactome:673142 "DNA strand elongation" xref: Reactome:678837 "DNA strand elongation" xref: Reactome:683773 "DNA strand elongation" xref: Reactome:689999 "DNA strand elongation" xref: Reactome:69190 "DNA strand elongation" xref: Reactome:701769 "DNA strand elongation" xref: Reactome:716345 "DNA strand elongation" xref: Reactome:720860 "DNA strand elongation" xref: Reactome:728288 "DNA strand elongation" xref: Reactome:731114 "DNA strand elongation" xref: Reactome:733116 "DNA strand elongation" xref: Reactome:733926 "DNA strand elongation" xref: Reactome:736602 "DNA strand elongation" xref: Reactome:738581 "DNA strand elongation" is_a: GO:0022616 ! DNA strand elongation relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006272 name: leading strand elongation namespace: biological_process def: "The synthesis of DNA from a template strand in the 5' to 3' direction; leading strand elongation is continuous as it proceeds in the same direction as the replication fork." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok is_a: GO:0006271 ! DNA strand elongation involved in DNA replication relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer [Term] id: GO:0006273 name: lagging strand elongation namespace: biological_process def: "The synthesis of DNA from a template strand in a net 3' to 5' direction. Lagging strand DNA elongation proceeds by discontinuous synthesis of short stretches of DNA, known as Okazaki fragments, from RNA primers; these fragments are then joined by DNA ligase. Although each segment of nascent DNA is synthesized in the 5' to 3' direction, the overall direction of lagging strand synthesis is 3' to 5', mirroring the progress of the replication fork." [ISBN:071673706X, ISBN:0815316194] subset: gosubset_prok is_a: GO:0006271 ! DNA strand elongation involved in DNA replication relationship: has_part GO:0006269 ! DNA replication, synthesis of RNA primer [Term] id: GO:0006274 name: DNA replication termination namespace: biological_process def: "The process by which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet." [GOC:mah, PMID:10209736, PMID:12009298] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006261 ! DNA-dependent DNA replication [Term] id: GO:0006275 name: regulation of DNA replication namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051052 ! regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006260 ! DNA replication relationship: regulates GO:0006260 ! DNA replication [Term] id: GO:0006276 name: plasmid maintenance namespace: biological_process def: "The maintenance of the integrity of extrachromosomal plasmid DNA; includes processes that ensure plasmids are retained in the daughter cells after cell division." [GOC:ai] subset: goslim_pir subset: gosubset_prok is_a: GO:0009987 ! cellular process [Term] id: GO:0006277 name: DNA amplification namespace: biological_process def: "The process by which the number of copies of a gene is increased in certain cells as extra copies of DNA are made in response to certain signals of cell development or of stress from the environment." [ISBN:0721601464] subset: gosubset_prok is_a: GO:0006260 ! DNA replication [Term] id: GO:0006278 name: RNA-dependent DNA replication namespace: biological_process def: "The process whereby new strands of DNA are synthesized, using RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:162589 "Reverse Transcription of HIV RNA" xref: Reactome:164516 "Minus-strand DNA synthesis" xref: Reactome:164525 "Plus-strand DNA synthesis" is_a: GO:0006260 ! DNA replication [Term] id: GO:0006279 name: premeiotic DNA synthesis namespace: biological_process def: "The replication of DNA that precedes meiotic cell division." [GOC:ai] synonym: "meiotic DNA replication" EXACT [] synonym: "meiotic DNA synthesis" EXACT [] synonym: "premeiotic DNA replication" EXACT [] is_a: GO:0006260 ! DNA replication [Term] id: GO:0006280 name: mutagenesis namespace: biological_process def: "OBSOLETE. The process by which genetic material undergoes a detectable and heritable structural change. There are three categories of mutation: genome mutations, involving addition or subtraction of one or more whole chromosomes; chromosome mutations, which alter the structure of chromosomes; and gene mutations, where the structure of a gene is altered at the molecular level." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because mutagenesis is not a valid biological process in which gene products would normally participate. Rather, mutations arise from DNA replication errors or damage by an extrinsic agent. subset: gosubset_prok is_obsolete: true consider: GO:0006281 consider: GO:0051276 [Term] id: GO:0006281 name: DNA repair namespace: biological_process def: "The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway." [PMID:11563486] subset: goslim_pir subset: goslim_pombe subset: gosubset_prok xref: Reactome:562607 "DNA Repair" xref: Reactome:563286 "DNA Damage Reversal" xref: Reactome:588233 "DNA Repair" xref: Reactome:588900 "DNA Damage Reversal" xref: Reactome:608996 "DNA Repair" xref: Reactome:609618 "DNA Damage Reversal" xref: Reactome:633679 "DNA Repair" xref: Reactome:634321 "DNA Damage Reversal" xref: Reactome:645289 "DNA Repair" xref: Reactome:645795 "DNA Damage Reversal" xref: Reactome:655665 "DNA Repair" xref: Reactome:656116 "DNA Damage Reversal" xref: Reactome:660947 "DNA Repair" xref: Reactome:666721 "DNA Repair" xref: Reactome:667057 "DNA Damage Reversal" xref: Reactome:672819 "DNA Repair" xref: Reactome:673211 "DNA Damage Reversal" xref: Reactome:678542 "DNA Repair" xref: Reactome:683504 "DNA Repair" xref: Reactome:683825 "DNA Damage Reversal" xref: Reactome:689703 "DNA Repair" xref: Reactome:690064 "DNA Damage Reversal" xref: Reactome:701436 "DNA Repair" xref: Reactome:701827 "DNA Damage Reversal" xref: Reactome:716007 "DNA Repair" xref: Reactome:716402 "DNA Damage Reversal" xref: Reactome:720669 "DNA Repair" xref: Reactome:727957 "DNA Repair" xref: Reactome:728333 "DNA Damage Reversal" xref: Reactome:730992 "DNA Repair" xref: Reactome:733052 "DNA Repair" xref: Reactome:733131 "DNA Damage Reversal" xref: Reactome:733896 "DNA Repair" xref: Reactome:733937 "DNA Damage Reversal" xref: Reactome:735617 "DNA Repair" xref: Reactome:735669 "DNA Damage Reversal" xref: Reactome:736566 "DNA Repair" xref: Reactome:736623 "DNA Damage Reversal" xref: Reactome:738526 "DNA Repair" xref: Reactome:738603 "DNA Damage Reversal" xref: Reactome:73894 "DNA Repair" xref: Reactome:73942 "DNA Damage Reversal" xref: Wikipedia:DNA_repair is_a: GO:0006259 ! DNA metabolic process is_a: GO:0006974 ! response to DNA damage stimulus [Term] id: GO:0006282 name: regulation of DNA repair namespace: biological_process def: "Any process that modulates the frequency, rate or extent of DNA repair." [GOC:go_curators] subset: gosubset_prok is_a: GO:0051052 ! regulation of DNA metabolic process is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006281 ! DNA repair relationship: regulates GO:0006281 ! DNA repair [Term] id: GO:0006283 name: transcription-coupled nucleotide-excision repair namespace: biological_process def: "The nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway." [PMID:10197977, PMID:11900249] subset: gosubset_prok synonym: "TC-NER" EXACT [PMID:10197977] synonym: "TCR" RELATED [GOC:vw, PMID:18794354] synonym: "transcription-coupled NER" EXACT [GOC:mah] synonym: "transcription-coupled repair" EXACT [GOC:vw, PMID:18794354] xref: Reactome:562605 "Transcription-coupled NER (TC-NER)" xref: Reactome:588231 "Transcription-coupled NER (TC-NER)" xref: Reactome:608994 "Transcription-coupled NER (TC-NER)" xref: Reactome:633677 "Transcription-coupled NER (TC-NER)" xref: Reactome:645287 "Transcription-coupled NER (TC-NER)" xref: Reactome:655663 "Transcription-coupled NER (TC-NER)" xref: Reactome:660945 "Transcription-coupled NER (TC-NER)" xref: Reactome:666719 "Transcription-coupled NER (TC-NER)" xref: Reactome:672817 "Transcription-coupled NER (TC-NER)" xref: Reactome:678540 "Transcription-coupled NER (TC-NER)" xref: Reactome:683502 "Transcription-coupled NER (TC-NER)" xref: Reactome:689701 "Transcription-coupled NER (TC-NER)" xref: Reactome:701434 "Transcription-coupled NER (TC-NER)" xref: Reactome:716005 "Transcription-coupled NER (TC-NER)" xref: Reactome:720667 "Transcription-coupled NER (TC-NER)" xref: Reactome:727955 "Transcription-coupled NER (TC-NER)" xref: Reactome:731103 "Transcription-coupled NER (TC-NER)" xref: Reactome:733126 "Transcription-coupled NER (TC-NER)" xref: Reactome:733936 "Transcription-coupled NER (TC-NER)" xref: Reactome:736616 "Transcription-coupled NER (TC-NER)" xref: Reactome:738596 "Transcription-coupled NER (TC-NER)" xref: Reactome:73937 "Transcription-coupled NER (TC-NER)" is_a: GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006284 name: base-excision repair namespace: biological_process def: "In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase." [ISBN:0815316194] subset: gosubset_prok synonym: "BER" EXACT [] xref: Reactome:562874 "Base Excision Repair" xref: Reactome:588495 "Base Excision Repair" xref: Reactome:609391 "Base Excision Repair" xref: Reactome:633929 "Base Excision Repair" xref: Reactome:645498 "Base Excision Repair" xref: Reactome:655859 "Base Excision Repair" xref: Reactome:661133 "Base Excision Repair" xref: Reactome:666918 "Base Excision Repair" xref: Reactome:673040 "Base Excision Repair" xref: Reactome:678760 "Base Excision Repair" xref: Reactome:683601 "Base Excision Repair" xref: Reactome:689830 "Base Excision Repair" xref: Reactome:701552 "Base Excision Repair" xref: Reactome:716136 "Base Excision Repair" xref: Reactome:720733 "Base Excision Repair" xref: Reactome:728091 "Base Excision Repair" xref: Reactome:730991 "Base Excision Repair" xref: Reactome:733051 "Base Excision Repair" xref: Reactome:733904 "Base Excision Repair" xref: Reactome:735616 "Base Excision Repair" xref: Reactome:736565 "Base Excision Repair" xref: Reactome:738525 "Base Excision Repair" xref: Reactome:73884 "Base Excision Repair" xref: Wikipedia:Base_excision_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006285 name: base-excision repair, AP site formation namespace: biological_process def: "The formation of an AP site, a deoxyribose sugar with a missing base, by DNA glycosylase which recognizes an altered base in DNA and catalyzes its hydrolytic removal. This sugar phosphate is the substrate recognized by the AP endonuclease, which cuts the DNA phosphodiester backbone at the 5' side of the altered site to leave a gap which is subsequently repaired." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:563042 "Base-Excision Repair, AP Site Formation" xref: Reactome:588661 "Base-Excision Repair, AP Site Formation" xref: Reactome:609390 "Base-Excision Repair, AP Site Formation" xref: Reactome:634095 "Base-Excision Repair, AP Site Formation" xref: Reactome:645618 "Base-Excision Repair, AP Site Formation" xref: Reactome:655944 "Base-Excision Repair, AP Site Formation" xref: Reactome:661132 "Base-Excision Repair, AP Site Formation" xref: Reactome:666917 "Base-Excision Repair, AP Site Formation" xref: Reactome:673039 "Base-Excision Repair, AP Site Formation" xref: Reactome:678759 "Base-Excision Repair, AP Site Formation" xref: Reactome:683679 "Base-Excision Repair, AP Site Formation" xref: Reactome:689889 "Base-Excision Repair, AP Site Formation" xref: Reactome:701654 "Base-Excision Repair, AP Site Formation" xref: Reactome:716234 "Base-Excision Repair, AP Site Formation" xref: Reactome:720787 "Base-Excision Repair, AP Site Formation" xref: Reactome:728185 "Base-Excision Repair, AP Site Formation" xref: Reactome:731029 "Base-Excision Repair, AP Site Formation" xref: Reactome:733083 "Base-Excision Repair, AP Site Formation" xref: Reactome:733903 "Base-Excision Repair, AP Site Formation" xref: Reactome:735628 "Base-Excision Repair, AP Site Formation" xref: Reactome:736573 "Base-Excision Repair, AP Site Formation" xref: Reactome:738537 "Base-Excision Repair, AP Site Formation" xref: Reactome:73929 "Base-Excision Repair, AP Site Formation" is_a: GO:0006308 ! DNA catabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006286 name: base-excision repair, base-free sugar-phosphate removal namespace: biological_process def: "Excision of the sugar phosphate residue at an AP site, i.e. a deoxyribose sugar with a missing base, by a phosphodiesterase enzyme." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:110375 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:549292 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:576063 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:622737 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:724934 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" xref: Reactome:737632 "Excision of the abasic sugar phosphate (dRP) residue at the strand break" is_a: GO:0006308 ! DNA catabolic process is_a: GO:0016311 ! dephosphorylation relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006287 name: base-excision repair, gap-filling namespace: biological_process def: "Repair of the damaged strand by the combined action of an apurinic endouclease that degrades a few bases on the damaged strand and a polymerase that synthesizes a 'patch' in the 5' to 3' direction, using the undamaged strand as a template." [ISBN:1550091131] subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006288 name: base-excision repair, DNA ligation namespace: biological_process def: "The ligation by DNA ligase of DNA strands. Ligation occurs after polymerase action to fill the gap left by the action of endonucleases during base-excision repair." [ISBN:1550091131] subset: gosubset_prok xref: Reactome:110370 "Ligation of DNA at sites of patch replacement" xref: Reactome:548458 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:554511 "Ligation of DNA at sites of patch replacement" xref: Reactome:575374 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:580311 "Ligation of DNA at sites of patch replacement" xref: Reactome:622152 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:627193 "Ligation of DNA at sites of patch replacement" xref: Reactome:671193 "Ligation of DNA at sites of patch replacement" xref: Reactome:677128 "Ligation of DNA at sites of patch replacement" xref: Reactome:682217 "Ligation of DNA at sites of patch replacement" xref: Reactome:698699 "Ligation of DNA at sites of patch replacement" xref: Reactome:712729 "Ligation of DNA at sites of patch replacement" xref: Reactome:724757 "DNA ligation via the single-nucleotide replacement pathway" xref: Reactome:73931 "DNA ligation via the single-nucleotide replacement pathway" is_a: GO:0051103 ! DNA ligation involved in DNA repair relationship: part_of GO:0006284 ! base-excision repair [Term] id: GO:0006289 name: nucleotide-excision repair namespace: biological_process alt_id: GO:0045001 def: "A DNA repair process in which a small region of the strand surrounding the damage is removed from the DNA helix as an oligonucleotide. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. Nucleotide excision repair recognizes a wide range of substrates, including damage caused by UV irradiation (pyrimidine dimers and 6-4 photoproducts) and chemicals (intrastrand cross-links and bulky adducts)." [PMID:10197977] comment: Note that although intrastrand cross-link repair is not exactly synonymous with nucleotide excision repair, nucleotide excision repair includes the repair of intrastrand cross-links. The synonym field is being used to reflect the broad substrate specificity of nucleotide excision repair. subset: gosubset_prok synonym: "interstrand crosslink repair" NARROW [] synonym: "intrastrand cross-link repair" RELATED [] synonym: "NER" EXACT [] synonym: "pyrimidine-dimer repair, DNA damage excision" EXACT [] xref: Reactome:562606 "Nucleotide Excision Repair" xref: Reactome:588232 "Nucleotide Excision Repair" xref: Reactome:608995 "Nucleotide Excision Repair" xref: Reactome:633678 "Nucleotide Excision Repair" xref: Reactome:645288 "Nucleotide Excision Repair" xref: Reactome:655664 "Nucleotide Excision Repair" xref: Reactome:660946 "Nucleotide Excision Repair" xref: Reactome:666720 "Nucleotide Excision Repair" xref: Reactome:672818 "Nucleotide Excision Repair" xref: Reactome:678541 "Nucleotide Excision Repair" xref: Reactome:683503 "Nucleotide Excision Repair" xref: Reactome:689702 "Nucleotide Excision Repair" xref: Reactome:701435 "Nucleotide Excision Repair" xref: Reactome:716006 "Nucleotide Excision Repair" xref: Reactome:720668 "Nucleotide Excision Repair" xref: Reactome:727956 "Nucleotide Excision Repair" xref: Reactome:731104 "Nucleotide Excision Repair" xref: Reactome:733124 "Nucleotide Excision Repair" xref: Reactome:733934 "Nucleotide Excision Repair" xref: Reactome:736614 "Nucleotide Excision Repair" xref: Reactome:738594 "Nucleotide Excision Repair" xref: Reactome:73885 "Nucleotide Excision Repair" is_a: GO:0006281 ! DNA repair [Term] id: GO:0006290 name: pyrimidine dimer repair namespace: biological_process def: "The repair of UV-induced T-T, C-T and C-C dimers." [ISBN:0815316194] subset: gosubset_prok is_a: GO:0006281 ! DNA repair [Term] id: GO:0006291 name: pyrimidine-dimer repair, DNA damage excision namespace: biological_process def: "OBSOLETE. The excision of damaged DNA during pyrimidine-dimer repair. A large multienzyme complex scans the DNA for a distortion in the double helix rather than for a specific base change. Once a bulky lesion is found, the phosphodiester backbone of the abnormal strand is cleaved on both sides of the distortion, and the portion of the strand containing the lesion (an oligonucleotide) is peeled away from the DNA double helix by a DNA helicase enzyme." [ISBN:0815316194] comment: This term was made obsolete because this process can be subdivided into multiple processes. is_obsolete: true consider: GO:0006289 [Term] id: GO:0006292 name: pyrimidine-dimer repair, DNA damage recognition namespace: biological_process def: "OBSOLETE. The location of pyrimidine dimers by a large multienzyme complex that scans the DNA for distortions in the double helix caused by pyrimidine dimers." [ISBN:0815316194] comment: This term was made obsolete because it is a substrate specific DNA repair process. is_obsolete: true consider: GO:0000715 consider: GO:0000716 [Term] id: GO:0006293 name: nucleotide-excision repair, preincision complex stabilization namespace: biological_process def: "The stabilization of the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage as well as the unwound DNA. The stabilization of the protein-DNA complex ensures proper positioning of the preincision complex before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok xref: Reactome:109953 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:543883 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:570981 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:617719 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:638170 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:649082 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:663439 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:669197 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:675335 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:680626 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:686076 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:694638 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:707401 "Binding of ERCC1-XPF to preincision complex" xref: Reactome:723437 "Binding of ERCC1-XPF to preincision complex" is_a: GO:0031334 ! positive regulation of protein complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006294 name: nucleotide-excision repair, preincision complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of proteins on DNA to form the multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage. This assembly occurs before the phosphodiester backbone of the damaged strand is cleaved 3' and 5' of the site of DNA damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, preincision complex formation" EXACT [] xref: Reactome:559734 "Recruitment of repair factors to form preincision complex" xref: Reactome:585497 "Recruitment of repair factors to form preincision complex" xref: Reactome:606741 "Recruitment of repair factors to form preincision complex" xref: Reactome:73936 "Recruitment of repair factors to form preincision complex" is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006295 name: nucleotide-excision repair, DNA incision, 3'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 3' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision precedes the incision formed 5' to the site of damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, DNA incision, 3' to lesion" EXACT [] xref: Reactome:537391 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:564128 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:589656 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:610643 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:634902 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:646416 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:656494 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:661643 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:667457 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:673544 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:679271 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:684247 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:690749 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:702696 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:721348 "3'- incision of DNA by XPG in GG-NER" xref: Reactome:73938 "3'- incision of DNA by XPG in GG-NER" is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006296 name: nucleotide-excision repair, DNA incision, 5'-to lesion namespace: biological_process def: "The endonucleolytic cleavage of the damaged strand of DNA 5' to the site of damage. The incision occurs at the junction of single-stranded DNA and double-stranded DNA that is formed when the DNA duplex is unwound. The incision follows the incision formed 3' to the site of damage." [GOC:elh, PMID:10197977] subset: gosubset_prok synonym: "nucleotide-excision repair, DNA incision, 5' to lesion" EXACT [] xref: Reactome:537575 "5'-incision of DNA by ERCC1-XPF in GG-NER" xref: Reactome:564315 "5'-incision of DNA by ERCC1-XPF in GG-NER" xref: Reactome:73939 "5'-incision of DNA by ERCC1-XPF in GG-NER" is_a: GO:0033683 ! nucleotide-excision repair, DNA incision [Term] id: GO:0006297 name: nucleotide-excision repair, DNA gap filling namespace: biological_process def: "Repair of the gap in the DNA helix by DNA polymerase and DNA ligase after the portion of the strand containing the lesion has been removed by pyrimidine-dimer repair enzymes." [ISBN:0815316194] subset: gosubset_prok xref: Reactome:563269 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:588878 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:609597 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:634303 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:645771 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:656098 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:661268 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:667042 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:673188 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:678880 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:683809 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:690041 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:701807 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:716382 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:720869 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:728319 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:731138 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:733122 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:733932 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:736612 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:738592 "Gap-filling DNA repair synthesis and ligation in GG-NER" xref: Reactome:74969 "Gap-filling DNA repair synthesis and ligation in GG-NER" is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006289 ! nucleotide-excision repair [Term] id: GO:0006298 name: mismatch repair namespace: biological_process alt_id: GO:0006300 def: "A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11687886] subset: gosubset_prok synonym: "long patch mismatch repair system" NARROW [] synonym: "mismatch repair, MutL-like pathway" RELATED [] synonym: "MMR" EXACT [] synonym: "MutS/MutL/MutH pathway" RELATED [] xref: Wikipedia:DNA_mismatch_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006299 name: short patch mismatch repair system namespace: biological_process def: "OBSOLETE. The repair of mismatched DNA where the gap to be repaired is only one nucleotide. DNA polymerase is the preferred polymerase in short patch repair, performing gap filling DNA synthesis and removal of the 5'-deoxyribose phosphate of the abasic site." [PMID:10660619, PMID:10878254] comment: This term was made obsolete because 'short patch' is a relative statement, often used ambiguously, and does not necessarily represent a process; the processes it can stand for are base excision repair, nucleotide excision repair, transcription-coupled nucleotide excision repair, and mismatch repair. is_obsolete: true consider: GO:0006284 consider: GO:0006289 [Term] id: GO:0006301 name: postreplication repair namespace: biological_process def: "The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication. Includes pathways that remove replication-blocking lesions in conjunction with DNA replication." [GOC:elh] subset: gosubset_prok xref: Wikipedia:Postreplication_repair is_a: GO:0006281 ! DNA repair [Term] id: GO:0006302 name: double-strand break repair namespace: biological_process def: "The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix." [GOC:elh] subset: gosubset_prok xref: Reactome:562636 "Double-Strand Break Repair" xref: Reactome:588262 "Double-Strand Break Repair" xref: Reactome:609255 "Double-Strand Break Repair" xref: Reactome:633955 "Double-Strand Break Repair" xref: Reactome:645534 "Double-Strand Break Repair" xref: Reactome:655879 "Double-Strand Break Repair" xref: Reactome:661065 "Double-Strand Break Repair" xref: Reactome:666843 "Double-Strand Break Repair" xref: Reactome:672958 "Double-Strand Break Repair" xref: Reactome:678676 "Double-Strand Break Repair" xref: Reactome:683625 "Double-Strand Break Repair" xref: Reactome:689850 "Double-Strand Break Repair" xref: Reactome:701575 "Double-Strand Break Repair" xref: Reactome:716159 "Double-Strand Break Repair" xref: Reactome:720744 "Double-Strand Break Repair" xref: Reactome:728103 "Double-Strand Break Repair" xref: Reactome:731006 "Double-Strand Break Repair" xref: Reactome:733060 "Double-Strand Break Repair" xref: Reactome:733895 "Double-Strand Break Repair" xref: Reactome:736611 "Double-Strand Break Repair" xref: Reactome:738591 "Double-Strand Break Repair" xref: Reactome:73890 "Double-Strand Break Repair" is_a: GO:0006281 ! DNA repair [Term] id: GO:0006303 name: double-strand break repair via nonhomologous end joining namespace: biological_process def: "The repair of a double-strand break in DNA in which the two broken ends are rejoined with little or no sequence complementarity. Information at the DNA ends may be lost due to the modification of broken DNA ends." [PMID:10827453] subset: gosubset_prok synonym: "NHEJ" EXACT [] xref: Reactome:562896 "Nonhomologous End-joining (NHEJ)" xref: Reactome:588517 "Nonhomologous End-joining (NHEJ)" xref: Reactome:609256 "Nonhomologous End-joining (NHEJ)" xref: Reactome:633954 "Nonhomologous End-joining (NHEJ)" xref: Reactome:645535 "Nonhomologous End-joining (NHEJ)" xref: Reactome:655878 "Nonhomologous End-joining (NHEJ)" xref: Reactome:661064 "Nonhomologous End-joining (NHEJ)" xref: Reactome:666842 "Nonhomologous End-joining (NHEJ)" xref: Reactome:672957 "Nonhomologous End-joining (NHEJ)" xref: Reactome:678675 "Nonhomologous End-joining (NHEJ)" xref: Reactome:701576 "Nonhomologous End-joining (NHEJ)" xref: Reactome:716160 "Nonhomologous End-joining (NHEJ)" xref: Reactome:728102 "Nonhomologous End-joining (NHEJ)" xref: Reactome:73889 "Nonhomologous End-joining (NHEJ)" is_a: GO:0000726 ! non-recombinational repair is_a: GO:0006302 ! double-strand break repair [Term] id: GO:0006304 name: DNA modification namespace: biological_process def: "The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties." [GOC:jl, GOC:ma] subset: goslim_pir subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0006305 name: DNA alkylation namespace: biological_process def: "The addition of alkyl groups to many positions on all four bases of DNA. Alkylating agents can also modify the bases of incoming nucleotides in the course of DNA synthesis." [ISBN:0716735970] subset: gosubset_prok is_a: GO:0006304 ! DNA modification [Term] id: GO:0006306 name: DNA methylation namespace: biological_process def: "The covalent transfer of a methyl group to either N-6 of adenine or C-5 or N-4 of cytosine." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:DNA_methylation is_a: GO:0006305 ! DNA alkylation is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006307 name: DNA dealkylation involved in DNA repair namespace: biological_process def: "The repair of alkylation damage, e.g. the removal of the alkyl group at the O6-position of guanine by O6-alkylguanine-DNA alkyltransferase (AGT)." [PMID:10946226] subset: gosubset_prok xref: Reactome:112122 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:112126 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:555087 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:563317 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:563318 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:563319 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:580977 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:588932 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:588933 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:588934 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:603683 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:609652 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:609653 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:609654 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:627707 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:634347 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:634348 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:634349 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:642313 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:652856 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:665364 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:673209 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:673210 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:682371 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:688215 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:690077 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:690078 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:690079 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:701825 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:701826 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:716400 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:716401 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:726147 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:732561 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:733622 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:735079 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:736621 "ABH2 mediated Reversal of Alkylation Damage" xref: Reactome:736622 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:737959 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:738611 "ABH3 mediated Reversal of Alkylation Damage" xref: Reactome:738612 "Reversal of Alkylation Damage By DNA Dioxygenases" xref: Reactome:73892 "MGMT/hAGT mediated DNA Damage Reversal" xref: Reactome:73943 "Reversal of Alkylation Damage By DNA Dioxygenases" is_a: GO:0035510 ! DNA dealkylation relationship: part_of GO:0006281 ! DNA repair [Term] id: GO:0006308 name: DNA catabolic process namespace: biological_process def: "The cellular DNA metabolic process resulting in the breakdown of DNA, deoxyribonucleic acid, one of the two main types of nucleic acid, consisting of a long unbranched macromolecule formed from one or two strands of linked deoxyribonucleotides, the 3'-phosphate group of each constituent deoxyribonucleotide being joined in 3',5'-phosphodiester linkage to the 5'-hydroxyl group of the deoxyribose moiety of the next one." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "DNA breakdown" EXACT [] synonym: "DNA catabolism" EXACT [] synonym: "DNA degradation" EXACT [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006309 name: DNA fragmentation involved in apoptotic nuclear change namespace: biological_process alt_id: GO:0008178 def: "The cleavage of DNA during apoptosis, which usually occurs in two stages: cleavage into fragments of about 50 kbp followed by cleavage between nucleosomes to yield 200 bp fragments." [GOC:dph, GOC:mah, GOC:tb, ISBN:0721639976] synonym: "DNA catabolic process during apoptosis" EXACT [] synonym: "DNA catabolism during apoptosis" EXACT [] synonym: "DNA fragmentation" BROAD [] synonym: "endonucleolytic DNA catabolic process involved in apoptosis" EXACT [] xref: Reactome:140342 "Apoptosis induced DNA fragmentation" xref: Reactome:562910 "Apoptosis induced DNA fragmentation" xref: Reactome:588531 "Apoptosis induced DNA fragmentation" xref: Reactome:609272 "Apoptosis induced DNA fragmentation" xref: Reactome:633965 "Apoptosis induced DNA fragmentation" xref: Reactome:645527 "Apoptosis induced DNA fragmentation" is_a: GO:0000737 ! DNA catabolic process, endonucleolytic is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis relationship: part_of GO:0030262 ! apoptotic nuclear change [Term] id: GO:0006310 name: DNA recombination namespace: biological_process def: "Any process by which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Intrachromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok is_a: GO:0006259 ! DNA metabolic process [Term] id: GO:0006311 name: meiotic gene conversion namespace: biological_process def: "The cell cycle process whereby genetic information is transferred from one helix to another. It often occurs in association with general genetic recombination events, and is believed to be a straightforward consequence of the mechanisms of general recombination and DNA repair. For example, meiosis might yield three copies of the maternal version of an allele and only one copy of the paternal allele, indicating that one of the two copies of the paternal allele has been changed to a copy of the maternal allele." [ISBN:0815316194] synonym: "gene conversion without reciprocal crossover" EXACT [] is_a: GO:0006310 ! DNA recombination is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0006312 name: mitotic recombination namespace: biological_process def: "The exchange, reciprocal or nonreciprocal, of genetic material between one DNA molecule and a homologous region of DNA that occurs during mitotic cell cycles." [GOC:elh] xref: Wikipedia:Mitotic_crossover is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006313 name: transposition, DNA-mediated namespace: biological_process alt_id: GO:0006317 alt_id: GO:0006318 def: "Any process involved in a type of transpositional recombination which occurs via a DNA intermediate." [GOC:jp, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:1555812090] subset: gosubset_prok synonym: "Class II transposition" EXACT [] synonym: "cut-and-paste transposition" EXACT [] synonym: "DNA transposition" EXACT [GOC:dph] synonym: "P-element excision" NARROW [] synonym: "P-element transposition" NARROW [] synonym: "Tc1/mariner transposition" NARROW [] synonym: "Tc3 transposition" NARROW [] is_a: GO:0006310 ! DNA recombination is_a: GO:0032196 ! transposition [Term] id: GO:0006314 name: intron homing namespace: biological_process def: "Lateral transfer of an intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron." [PMID:10487208] subset: gosubset_prok is_a: GO:0006310 ! DNA recombination [Term] id: GO:0006315 name: homing of group II introns namespace: biological_process def: "Lateral transfer of a group II intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group II introns are self-splicing introns with a conserved secondary structure." [GOC:mcc, ISBN:0716743663, PMID:10487208] subset: gosubset_prok is_a: GO:0006314 ! intron homing [Term] id: GO:0006316 name: movement of group I intron namespace: biological_process def: "Lateral transfer of a group I intron to a homologous allele that lacks the intron, mediated by a site-specific endonuclease encoded within the mobile intron; group I introns are self-splicing introns that use guanosine as a cofactor in the splicing reaction." [GOC:mcc, ISBN:0716743663, PMID:10487208] subset: gosubset_prok is_a: GO:0006314 ! intron homing [Term] id: GO:0006323 name: DNA packaging namespace: biological_process def: "Any process by which DNA and associated proteins are formed into a compact, orderly structure." [GOC:mah, ISBN:0815316194] subset: goslim_pir synonym: "DNA organisation" EXACT [GOC:curators] synonym: "DNA organization" EXACT [GOC:curators] is_a: GO:0016043 ! cellular component organization is_a: GO:0071103 ! DNA conformation change [Term] id: GO:0006324 name: S-phase-specific histone modification namespace: biological_process def: "The covalent alteration of one or more amino acid residues within a histone protein that takes place during, and results in a modification pattern characteristic of, S phase of the cell cycle." [GOC:mah, PMID:9990026] is_a: GO:0016570 ! histone modification relationship: part_of GO:0051320 ! S phase [Term] id: GO:0006325 name: chromatin organization namespace: biological_process def: "Any process that results in the specification, formation or maintenance of the physical structure of eukaryotic chromatin." [GOC:mah] synonym: "establishment or maintenance of chromatin architecture" EXACT [GOC:mah] is_a: GO:0051276 ! chromosome organization [Term] id: GO:0006326 name: bent DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003681 [Term] id: GO:0006327 name: random coil binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0003695 [Term] id: GO:0006328 name: AT binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003680 [Term] id: GO:0006329 name: satellite DNA binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003696 [Term] id: GO:0006330 name: single-stranded DNA binding namespace: biological_process alt_id: GO:0006331 alt_id: GO:0006332 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0003697 [Term] id: GO:0006333 name: chromatin assembly or disassembly namespace: biological_process def: "The formation or destruction of chromatin structures." [GOC:mah] synonym: "chromatin assembly/disassembly" EXACT [] is_a: GO:0006325 ! chromatin organization [Term] id: GO:0006334 name: nucleosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a nucleosome, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] synonym: "histone chaperone" RELATED [GOC:vw] synonym: "nucleosome modeling" EXACT [] is_a: GO:0034728 ! nucleosome organization is_a: GO:0065004 ! protein-DNA complex assembly relationship: part_of GO:0031497 ! chromatin assembly [Term] id: GO:0006335 name: DNA replication-dependent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes on newly replicated DNA, coupled to strand elongation." [GOC:mah] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034723 ! DNA replication-dependent nucleosome organization [Term] id: GO:0006336 name: DNA replication-independent nucleosome assembly namespace: biological_process def: "The formation of nucleosomes outside the context of DNA replication." [GOC:mah] synonym: "transcription-coupled nucleosome assembly" EXACT [] is_a: GO:0006334 ! nucleosome assembly is_a: GO:0034724 ! DNA replication-independent nucleosome organization [Term] id: GO:0006337 name: nucleosome disassembly namespace: biological_process def: "The controlled breakdown of nucleosomes, the beadlike structural units of eukaryotic chromatin composed of histones and DNA." [GOC:mah] is_a: GO:0032986 ! protein-DNA complex disassembly is_a: GO:0034728 ! nucleosome organization relationship: part_of GO:0031498 ! chromatin disassembly [Term] id: GO:0006338 name: chromatin remodeling namespace: biological_process def: "Dynamic structural changes to eukaryotic chromatin occurring throughout the cell division cycle. These changes range from the local changes necessary for transcriptional regulation to global changes necessary for chromosome segregation." [GOC:jid, PMID:12697820] synonym: "chromatin modeling" EXACT [] synonym: "chromatin modelling" EXACT [] synonym: "chromatin remodelling" EXACT [] is_a: GO:0016568 ! chromatin modification [Term] id: GO:0006339 name: positive regulation of transcription of homeotic gene (trithorax group) namespace: biological_process def: "OBSOLETE. Any process that activates or increases the frequency, rate or extent of transcription of homeotic genes of the trithorax group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006340 name: negative regulation of transcription of homeotic gene (Polycomb group) namespace: biological_process def: "OBSOLETE. Any process that stops, prevents or reduces the frequency, rate or extent of transcription of homeotic genes of the Polycomb group." [GOC:go_curators] comment: This term was made obsolete because it relates to a specific gene family rather than a process. is_obsolete: true consider: GO:0006342 consider: GO:0048096 [Term] id: GO:0006341 name: chromatin insulator sequence binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0043035 [Term] id: GO:0006342 name: chromatin silencing namespace: biological_process alt_id: GO:0016440 def: "Repression of transcription by altering the structure of chromatin, e.g. by conversion of large regions of DNA into an inaccessible state often called heterochromatin." [GOC:mah, PMID:10219245] comment: Note that this process is the opposite of chromatin-mediated maintenance of transcription. This regulation is exemplified by members of the Polycomb group, which maintain the inactive state of homeotic gene transcription. synonym: "chromatin-mediated maintenance of transcriptional inactivation" EXACT [] synonym: "chromatin-mediated silencing" EXACT [] synonym: "heterochromatic silencing" RELATED [] synonym: "TGS" EXACT [] synonym: "transcriptional gene silencing" EXACT [] is_a: GO:0016458 ! gene silencing is_a: GO:0045814 ! negative regulation of gene expression, epigenetic is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent [Term] id: GO:0006343 name: establishment of chromatin silencing namespace: biological_process def: "The initial formation of a transcriptionally silent chromatin structure such as heterochromatin." [GOC:mah] synonym: "establishment of heterochromatic silencing" RELATED [] is_a: GO:0006338 ! chromatin remodeling relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006344 name: maintenance of chromatin silencing namespace: biological_process def: "The maintenance of chromatin in a transciptionally silent state such as heterochromatin." [GOC:mah] synonym: "maintenance of heterochromatic silencing" RELATED [] is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0006342 ! chromatin silencing [Term] id: GO:0006345 name: loss of chromatin silencing namespace: biological_process def: "The process leading to expression of genes that are typically not expressed due to silencing by regulatory proteins." [GOC:go_curators] is_a: GO:0031936 ! negative regulation of chromatin silencing [Term] id: GO:0006346 name: methylation-dependent chromatin silencing namespace: biological_process def: "Repression of transcription by methylation of DNA, leading to the formation of heterochromatin." [GOC:mah] synonym: "methylation-dependent heterochromatic silencing" EXACT [] is_a: GO:0006342 ! chromatin silencing is_a: GO:0016569 ! covalent chromatin modification [Term] id: GO:0006348 name: chromatin silencing at telomere namespace: biological_process def: "Repression of transcription of telomeric DNA by altering the structure of chromatin." [PMID:10219245] synonym: "heterochromatic silencing at telomere" EXACT [] synonym: "telomeric silencing" EXACT [GOC:bf] is_a: GO:0006342 ! chromatin silencing [Term] id: GO:0006349 name: regulation of gene expression by genetic imprinting namespace: biological_process def: "Heritable alterations in the activity of a gene that depend on whether it passed through the paternal or the maternal germline, but that are not encoded by DNA itself." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11498578] synonym: "regulation of gene expression by DNA imprinting" EXACT [GOC:mah] xref: Wikipedia:Genomic_imprinting is_a: GO:0040029 ! regulation of gene expression, epigenetic is_a: GO:0071514 ! genetic imprinting [Term] id: GO:0006350 name: transcription namespace: biological_process alt_id: GO:0061018 def: "The cellular synthesis of either RNA on a template of DNA or DNA on a template of RNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cellular transcription" EXACT [] xref: Reactome:504046 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:562664 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:562665 "Transcription" xref: Reactome:588289 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:588290 "Transcription" xref: Reactome:609132 "Transcription" xref: Reactome:609248 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:633828 "Transcription" xref: Reactome:633948 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:645418 "Transcription" xref: Reactome:645572 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:655785 "Transcription" xref: Reactome:655870 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:660999 "Transcription" xref: Reactome:661089 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:666778 "Transcription" xref: Reactome:666840 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:672886 "Transcription" xref: Reactome:672953 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:678603 "Transcription" xref: Reactome:678668 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:683555 "Transcription" xref: Reactome:683607 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:689763 "Transcription" xref: Reactome:689841 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:701501 "Transcription" xref: Reactome:701563 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:716073 "Transcription" xref: Reactome:716147 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:720856 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:720857 "Transcription" xref: Reactome:728020 "Transcription" xref: Reactome:728101 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:730946 "Transcription" xref: Reactome:730998 "RNA Polymerase I, RNA Polymerase III, and Mitochondrial Transcription" xref: Reactome:74159 "Transcription" xref: Wikipedia:Transcription_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0090304 ! nucleic acid metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006351 name: transcription, DNA-dependent namespace: biological_process alt_id: GO:0061022 def: "The cellular synthesis of RNA on a template of DNA." [GOC:jl] subset: gosubset_prok synonym: "cellular transcription, DNA-dependent" EXACT [] is_a: GO:0006350 ! transcription is_a: GO:0032774 ! RNA biosynthetic process [Term] id: GO:0006352 name: transcription initiation namespace: biological_process def: "Any process involved in the assembly of the RNA polymerase complex at the promoter region of a DNA template, resulting in the subsequent synthesis of RNA from that promoter." [GOC:jid] subset: gosubset_prok synonym: "RNA polymerase complex assembly at promoter" EXACT [] is_a: GO:0006461 ! protein complex assembly relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006353 name: transcription termination namespace: biological_process def: "The process by which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA." [ISBN:0716720094] subset: gosubset_prok synonym: "transcriptional complex disassembly" EXACT [] is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006354 name: RNA elongation namespace: biological_process def: "The extension of an RNA molecule after transcription initiation by the addition of ribonucleotides catalyzed by an RNA polymerase." [GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "transcription elongation" BROAD [] synonym: "transcriptional elongation" BROAD [] is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006355 name: regulation of transcription, DNA-dependent namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular DNA-dependent transcription." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of cellular transcription, DNA-dependent" EXACT [] synonym: "transcriptional control" BROAD [] is_a: GO:0045449 ! regulation of transcription is_a: GO:0051252 ! regulation of RNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006351 ! transcription, DNA-dependent relationship: regulates GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006356 name: regulation of transcription from RNA polymerase I promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase I promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol I promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006360 ! transcription from RNA polymerase I promoter relationship: regulates GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006357 name: regulation of transcription from RNA polymerase II promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol II promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006366 ! transcription from RNA polymerase II promoter relationship: regulates GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006358 name: regulation of transcription from RNA polymerase II promoter, global namespace: biological_process def: "Any process that modulates the frequency, rate or extent of global transcription from Pol II promoter." [GOC:go_curators] synonym: "global transcription regulation from Pol II promoter" EXACT [] synonym: "regulation of global transcription from Pol II promoter" EXACT [] is_a: GO:0006357 ! regulation of transcription from RNA polymerase II promoter [Term] id: GO:0006359 name: regulation of transcription from RNA polymerase III promoter namespace: biological_process def: "Any process that modulates the frequency, rate or extent of transcription from an RNA ploymerase III promoter." [GOC:go_curators] synonym: "regulation of transcription from Pol III promoter" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006383 ! transcription from RNA polymerase III promoter relationship: regulates GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006360 name: transcription from RNA polymerase I promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase I (Pol I), originating at a Pol I-specific promoter." [GOC:jl] synonym: "transcription from Pol I promoter" EXACT [] xref: Reactome:562663 "RNA Polymerase I Transcription" xref: Reactome:588288 "RNA Polymerase I Transcription" xref: Reactome:609247 "RNA Polymerase I Transcription" xref: Reactome:633947 "RNA Polymerase I Transcription" xref: Reactome:645571 "RNA Polymerase I Transcription" xref: Reactome:655869 "RNA Polymerase I Transcription" xref: Reactome:661088 "RNA Polymerase I Transcription" xref: Reactome:666839 "RNA Polymerase I Transcription" xref: Reactome:672952 "RNA Polymerase I Transcription" xref: Reactome:678667 "RNA Polymerase I Transcription" xref: Reactome:683606 "RNA Polymerase I Transcription" xref: Reactome:689840 "RNA Polymerase I Transcription" xref: Reactome:701562 "RNA Polymerase I Transcription" xref: Reactome:716146 "RNA Polymerase I Transcription" xref: Reactome:728100 "RNA Polymerase I Transcription" xref: Reactome:730997 "RNA Polymerase I Transcription" xref: Reactome:73864 "RNA Polymerase I Transcription" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006361 name: transcription initiation from RNA polymerase I promoter namespace: biological_process def: "A transcription initiation process that results in RNA synthesis by RNA polymerase I." [GOC:mah] synonym: "transcription initiation from Pol I promoter" EXACT [] xref: Reactome:562661 "RNA Polymerase I Transcription Initiation" xref: Reactome:562662 "RNA Polymerase I Promoter Clearance" xref: Reactome:563273 "RNA Polymerase I Promoter Escape" xref: Reactome:563347 "RNA Polymerase I Promoter Opening" xref: Reactome:588286 "RNA Polymerase I Transcription Initiation" xref: Reactome:588287 "RNA Polymerase I Promoter Clearance" xref: Reactome:588887 "RNA Polymerase I Promoter Escape" xref: Reactome:588964 "RNA Polymerase I Promoter Opening" xref: Reactome:609245 "RNA Polymerase I Transcription Initiation" xref: Reactome:609246 "RNA Polymerase I Promoter Clearance" xref: Reactome:609605 "RNA Polymerase I Promoter Escape" xref: Reactome:633945 "RNA Polymerase I Transcription Initiation" xref: Reactome:633946 "RNA Polymerase I Promoter Clearance" xref: Reactome:634308 "RNA Polymerase I Promoter Escape" xref: Reactome:634375 "RNA Polymerase I Promoter Opening" xref: Reactome:645569 "RNA Polymerase I Transcription Initiation" xref: Reactome:645570 "RNA Polymerase I Promoter Clearance" xref: Reactome:655867 "RNA Polymerase I Transcription Initiation" xref: Reactome:655868 "RNA Polymerase I Promoter Clearance" xref: Reactome:656108 "RNA Polymerase I Promoter Escape" xref: Reactome:661086 "RNA Polymerase I Transcription Initiation" xref: Reactome:661087 "RNA Polymerase I Promoter Clearance" xref: Reactome:666837 "RNA Polymerase I Transcription Initiation" xref: Reactome:666838 "RNA Polymerase I Promoter Clearance" xref: Reactome:667048 "RNA Polymerase I Promoter Escape" xref: Reactome:672950 "RNA Polymerase I Transcription Initiation" xref: Reactome:672951 "RNA Polymerase I Promoter Clearance" xref: Reactome:673190 "RNA Polymerase I Promoter Escape" xref: Reactome:678665 "RNA Polymerase I Transcription Initiation" xref: Reactome:678666 "RNA Polymerase I Promoter Clearance" xref: Reactome:678882 "RNA Polymerase I Promoter Escape" xref: Reactome:683604 "RNA Polymerase I Transcription Initiation" xref: Reactome:683605 "RNA Polymerase I Promoter Clearance" xref: Reactome:683811 "RNA Polymerase I Promoter Escape" xref: Reactome:689838 "RNA Polymerase I Transcription Initiation" xref: Reactome:689839 "RNA Polymerase I Promoter Clearance" xref: Reactome:701560 "RNA Polymerase I Transcription Initiation" xref: Reactome:701561 "RNA Polymerase I Promoter Clearance" xref: Reactome:701809 "RNA Polymerase I Promoter Escape" xref: Reactome:701842 "RNA Polymerase I Promoter Opening" xref: Reactome:716144 "RNA Polymerase I Transcription Initiation" xref: Reactome:716145 "RNA Polymerase I Promoter Clearance" xref: Reactome:716384 "RNA Polymerase I Promoter Escape" xref: Reactome:716417 "RNA Polymerase I Promoter Opening" xref: Reactome:728098 "RNA Polymerase I Transcription Initiation" xref: Reactome:728099 "RNA Polymerase I Promoter Clearance" xref: Reactome:728325 "RNA Polymerase I Promoter Escape" xref: Reactome:730995 "RNA Polymerase I Transcription Initiation" xref: Reactome:730996 "RNA Polymerase I Promoter Clearance" xref: Reactome:73728 "RNA Polymerase I Promoter Opening" xref: Reactome:73762 "RNA Polymerase I Transcription Initiation" xref: Reactome:73772 "RNA Polymerase I Promoter Escape" xref: Reactome:73854 "RNA Polymerase I Promoter Clearance" is_a: GO:0006352 ! transcription initiation relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006362 name: RNA elongation from RNA polymerase I promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase I-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase I." [GOC:mah] synonym: "RNA elongation from Pol I promoter" EXACT [] xref: Reactome:563152 "RNA Polymerase I Chain Elongation" xref: Reactome:588763 "RNA Polymerase I Chain Elongation" xref: Reactome:609489 "RNA Polymerase I Chain Elongation" xref: Reactome:634195 "RNA Polymerase I Chain Elongation" xref: Reactome:656027 "RNA Polymerase I Chain Elongation" xref: Reactome:666983 "RNA Polymerase I Chain Elongation" xref: Reactome:673124 "RNA Polymerase I Chain Elongation" xref: Reactome:678820 "RNA Polymerase I Chain Elongation" xref: Reactome:683752 "RNA Polymerase I Chain Elongation" xref: Reactome:701747 "RNA Polymerase I Chain Elongation" xref: Reactome:716323 "RNA Polymerase I Chain Elongation" xref: Reactome:728266 "RNA Polymerase I Chain Elongation" xref: Reactome:73777 "RNA Polymerase I Chain Elongation" is_a: GO:0006354 ! RNA elongation relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006363 name: termination of RNA polymerase I transcription namespace: biological_process alt_id: GO:0019223 def: "The process by which the synthesis of an RNA molecule by RNA polymerase I using a DNA template is completed; typically occurs within U-rich regions." [GOC:mah, PMID:12944462] synonym: "RNA polymerase I transcription termination" EXACT [] synonym: "transcription termination from Pol I promoter" EXACT [] synonym: "transcription termination from RNA polymerase I promoter" EXACT [] xref: Reactome:563131 "RNA Polymerase I Transcription Termination" xref: Reactome:588743 "RNA Polymerase I Transcription Termination" xref: Reactome:609698 "RNA Polymerase I Transcription Termination" xref: Reactome:634179 "RNA Polymerase I Transcription Termination" xref: Reactome:701847 "RNA Polymerase I Transcription Termination" xref: Reactome:73863 "RNA Polymerase I Transcription Termination" is_a: GO:0006353 ! transcription termination relationship: part_of GO:0006360 ! transcription from RNA polymerase I promoter [Term] id: GO:0006364 name: rRNA processing namespace: biological_process alt_id: GO:0006365 def: "Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules." [GOC:curators] subset: gosubset_prok synonym: "35S primary transcript processing" NARROW [] is_a: GO:0016072 ! rRNA metabolic process is_a: GO:0034470 ! ncRNA processing relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006366 name: transcription from RNA polymerase II promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II-specific promoter. Includes transcription of messenger RNA (mRNA) and certain small nuclear RNAs (snRNAs)." [GOC:jl, ISBN:0321000382] synonym: "transcription from Pol II promoter" EXACT [] xref: Reactome:562778 "RNA Polymerase II Transcription" xref: Reactome:588394 "RNA Polymerase II Transcription" xref: Reactome:609131 "RNA Polymerase II Transcription" xref: Reactome:633827 "RNA Polymerase II Transcription" xref: Reactome:645417 "RNA Polymerase II Transcription" xref: Reactome:655784 "RNA Polymerase II Transcription" xref: Reactome:660998 "RNA Polymerase II Transcription" xref: Reactome:666777 "RNA Polymerase II Transcription" xref: Reactome:672885 "RNA Polymerase II Transcription" xref: Reactome:678602 "RNA Polymerase II Transcription" xref: Reactome:683554 "RNA Polymerase II Transcription" xref: Reactome:689762 "RNA Polymerase II Transcription" xref: Reactome:701500 "RNA Polymerase II Transcription" xref: Reactome:716072 "RNA Polymerase II Transcription" xref: Reactome:728019 "RNA Polymerase II Transcription" xref: Reactome:730945 "RNA Polymerase II Transcription" xref: Reactome:73857 "RNA Polymerase II Transcription" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006367 name: transcription initiation from RNA polymerase II promoter namespace: biological_process def: "A transcription initiation process that results in RNA synthesis by RNA polymerase II." [GOC:mah] synonym: "transcription initiation from Pol II promoter" EXACT [] xref: Reactome:167161 "HIV-1 Transcription Initiation" xref: Reactome:562993 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:563299 "RNA Polymerase II Transcription Initiation" xref: Reactome:588609 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:588916 "RNA Polymerase II Transcription Initiation" xref: Reactome:609352 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:609632 "RNA Polymerase II Transcription Initiation" xref: Reactome:634044 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:634330 "RNA Polymerase II Transcription Initiation" xref: Reactome:645573 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:645803 "RNA Polymerase II Transcription Initiation" xref: Reactome:655909 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:656130 "RNA Polymerase II Transcription Initiation" xref: Reactome:666870 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:667062 "RNA Polymerase II Transcription Initiation" xref: Reactome:672989 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:673205 "RNA Polymerase II Transcription Initiation" xref: Reactome:678706 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:678896 "RNA Polymerase II Transcription Initiation" xref: Reactome:683643 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:683830 "RNA Polymerase II Transcription Initiation" xref: Reactome:701612 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:701821 "RNA Polymerase II Transcription Initiation" xref: Reactome:716196 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:716396 "RNA Polymerase II Transcription Initiation" xref: Reactome:728145 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:728339 "RNA Polymerase II Transcription Initiation" xref: Reactome:73779 "RNA Polymerase II Transcription Pre-Initiation" xref: Reactome:75953 "RNA Polymerase II Transcription Initiation" is_a: GO:0006352 ! transcription initiation relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006368 name: RNA elongation from RNA polymerase II promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase II-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase II." [GOC:mah] synonym: "RNA elongation from Pol II promoter" EXACT [] xref: Reactome:112382 "Formation of RNA Pol II elongation complex" xref: Reactome:113418 "Formation of the Early Elongation Complex" xref: Reactome:167169 "HIV-1 Transcription Elongation" xref: Reactome:562815 "RNA Polymerase II Promoter Escape" xref: Reactome:562819 "RNA Polymerase II Transcription Elongation" xref: Reactome:563144 "Formation of the Early Elongation Complex" xref: Reactome:563239 "Formation of RNA Pol II elongation complex" xref: Reactome:588431 "RNA Polymerase II Promoter Escape" xref: Reactome:588435 "RNA Polymerase II Transcription Elongation" xref: Reactome:588755 "Formation of the Early Elongation Complex" xref: Reactome:588846 "Formation of RNA Pol II elongation complex" xref: Reactome:609173 "RNA Polymerase II Promoter Escape" xref: Reactome:609177 "RNA Polymerase II Transcription Elongation" xref: Reactome:609481 "Formation of the Early Elongation Complex" xref: Reactome:609567 "Formation of RNA Pol II elongation complex" xref: Reactome:633867 "RNA Polymerase II Promoter Escape" xref: Reactome:633871 "RNA Polymerase II Transcription Elongation" xref: Reactome:634187 "Formation of the Early Elongation Complex" xref: Reactome:634398 "Formation of RNA Pol II elongation complex" xref: Reactome:645449 "RNA Polymerase II Promoter Escape" xref: Reactome:645453 "RNA Polymerase II Transcription Elongation" xref: Reactome:645715 "Formation of the Early Elongation Complex" xref: Reactome:645748 "Formation of RNA Pol II elongation complex" xref: Reactome:655812 "RNA Polymerase II Promoter Escape" xref: Reactome:655816 "RNA Polymerase II Transcription Elongation" xref: Reactome:656018 "Formation of the Early Elongation Complex" xref: Reactome:656079 "Formation of RNA Pol II elongation complex" xref: Reactome:666796 "RNA Polymerase II Promoter Escape" xref: Reactome:667024 "Formation of the Early Elongation Complex" xref: Reactome:667025 "RNA Polymerase II Transcription Elongation" xref: Reactome:672907 "RNA Polymerase II Promoter Escape" xref: Reactome:673172 "Formation of the Early Elongation Complex" xref: Reactome:673173 "RNA Polymerase II Transcription Elongation" xref: Reactome:678621 "RNA Polymerase II Promoter Escape" xref: Reactome:678867 "Formation of the Early Elongation Complex" xref: Reactome:678868 "RNA Polymerase II Transcription Elongation" xref: Reactome:683561 "RNA Polymerase II Promoter Escape" xref: Reactome:683794 "Formation of the Early Elongation Complex" xref: Reactome:683795 "RNA Polymerase II Transcription Elongation" xref: Reactome:689780 "RNA Polymerase II Promoter Escape" xref: Reactome:690021 "Formation of the Early Elongation Complex" xref: Reactome:690022 "RNA Polymerase II Transcription Elongation" xref: Reactome:701502 "RNA Polymerase II Promoter Escape" xref: Reactome:701740 "Formation of the Early Elongation Complex" xref: Reactome:701741 "RNA Polymerase II Transcription Elongation" xref: Reactome:716074 "RNA Polymerase II Promoter Escape" xref: Reactome:716316 "Formation of the Early Elongation Complex" xref: Reactome:716317 "RNA Polymerase II Transcription Elongation" xref: Reactome:728038 "RNA Polymerase II Promoter Escape" xref: Reactome:728042 "RNA Polymerase II Transcription Elongation" xref: Reactome:728304 "Formation of the Early Elongation Complex" xref: Reactome:730947 "RNA Polymerase II Promoter Escape" xref: Reactome:73776 "RNA Polymerase II Promoter Escape" xref: Reactome:75955 "RNA Polymerase II Transcription Elongation" is_a: GO:0006354 ! RNA elongation relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006369 name: termination of RNA polymerase II transcription namespace: biological_process alt_id: GO:0019224 def: "The process by which the synthesis of an RNA molecule by RNA polymerase II using a DNA template is completed." [GOC:mah] synonym: "RNA polymerase II transcription termination" EXACT [] synonym: "transcription termination from Pol II promoter" EXACT [] synonym: "transcription termination from RNA polymerase II promoter" EXACT [] xref: Reactome:109688 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:167168 "HIV-1 Transcription Termination" xref: Reactome:563047 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:563048 "RNA Polymerase II Transcription Termination" xref: Reactome:609396 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:609397 "RNA Polymerase II Transcription Termination" xref: Reactome:634099 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:634100 "RNA Polymerase II Transcription Termination" xref: Reactome:645621 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:645622 "RNA Polymerase II Transcription Termination" xref: Reactome:655945 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:655946 "RNA Polymerase II Transcription Termination" xref: Reactome:701657 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:701658 "RNA Polymerase II Transcription Termination" xref: Reactome:716237 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:716238 "RNA Polymerase II Transcription Termination" xref: Reactome:728188 "Cleavage of Growing Transcript in the Termination Region" xref: Reactome:728189 "RNA Polymerase II Transcription Termination" xref: Reactome:73856 "RNA Polymerase II Transcription Termination" is_a: GO:0006353 ! transcription termination relationship: part_of GO:0006366 ! transcription from RNA polymerase II promoter [Term] id: GO:0006370 name: mRNA capping namespace: biological_process def: "Addition of the 7-methylguanosine cap to the 5' end of a nascent messenger RNA transcript." [GOC:mah, PMID:9266685] synonym: "5' end capping" BROAD [] synonym: "5' mRNA capping" EXACT [] synonym: "5'-end mRNA processing" EXACT [] synonym: "5'-end processing" BROAD [] xref: Reactome:563014 "mRNA Capping" xref: Reactome:588632 "mRNA Capping" xref: Reactome:609367 "mRNA Capping" xref: Reactome:634069 "mRNA Capping" xref: Reactome:645595 "mRNA Capping" xref: Reactome:655918 "mRNA Capping" xref: Reactome:661118 "mRNA Capping" xref: Reactome:666895 "mRNA Capping" xref: Reactome:673017 "mRNA Capping" xref: Reactome:678737 "mRNA Capping" xref: Reactome:683669 "mRNA Capping" xref: Reactome:689879 "mRNA Capping" xref: Reactome:701636 "mRNA Capping" xref: Reactome:716214 "mRNA Capping" xref: Reactome:72086 "mRNA Capping" xref: Reactome:728167 "mRNA Capping" xref: Reactome:731022 "mRNA Capping" is_a: GO:0006397 ! mRNA processing is_a: GO:0009452 ! RNA capping [Term] id: GO:0006371 name: mRNA splicing namespace: biological_process def: "OBSOLETE. The process in which excision of introns from the primary transcript of messenger RNA (mRNA) is followed by ligation of the two exon termini exposed by removal of each intron, so that mRNA consisting only of the joined exons is produced." [GOC:krc, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents several different processes. is_obsolete: true consider: GO:0000372 consider: GO:0000373 consider: GO:0000374 consider: GO:0000394 consider: GO:0000398 [Term] id: GO:0006372 name: lariat formation, 5'-splice site cleavage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0000350 consider: GO:0000386 [Term] id: GO:0006373 name: 3'-splice site cleavage, exon ligation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0000386 consider: GO:0000388 consider: GO:0000393 [Term] id: GO:0006376 name: mRNA splice site selection namespace: biological_process def: "Selection of a splice site by components of the assembling spliceosome." [GOC:krc, ISBN:0879695897] synonym: "spliceosomal commitment complex biosynthesis" NARROW [] synonym: "spliceosomal commitment complex formation" NARROW [] synonym: "spliceosomal E complex biosynthesis" NARROW [] synonym: "spliceosomal E complex formation" NARROW [] is_a: GO:0022618 ! ribonucleoprotein complex assembly relationship: part_of GO:0000245 ! spliceosome assembly [Term] id: GO:0006377 name: MATa1 (A1) pre-mRNA splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the MATa1 (A1) pre-mRNA, but a recycling defect exacerbated by the presence of two introns within the same gene. is_obsolete: true consider: GO:0000244 [Term] id: GO:0006378 name: mRNA polyadenylation namespace: biological_process def: "The enzymatic addition of a sequence of 40-200 adenylyl residues at the 3' end of a eukaryotic mRNA primary transcript." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cleavage and polyadenylylation specificity factor activity" NARROW [] synonym: "mRNA polyadenylylation" EXACT [] is_a: GO:0031124 ! mRNA 3'-end processing is_a: GO:0043631 ! RNA polyadenylation [Term] id: GO:0006379 name: mRNA cleavage namespace: biological_process def: "Any process by which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner." [GOC:mah] subset: gosubset_prok synonym: "cleavage and polyadenylylation specificity factor activity" RELATED [] synonym: "cleavage stimulation factor activity" RELATED [] synonym: "pre-mRNA cleavage factor activity" RELATED [] is_a: GO:0006397 ! mRNA processing is_a: GO:0090305 ! nucleic acid phosphodiester bond hydrolysis [Term] id: GO:0006380 name: poly-A binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0008143 [Term] id: GO:0006382 name: adenosine to inosine editing namespace: biological_process def: "The conversion of an adenosine residue to inosine in an RNA molecule by deamination." [PMID:11092837] subset: gosubset_prok xref: Reactome:562976 "mRNA Editing: A to I Conversion" xref: Reactome:588592 "mRNA Editing: A to I Conversion" xref: Reactome:609334 "mRNA Editing: A to I Conversion" xref: Reactome:634023 "mRNA Editing: A to I Conversion" xref: Reactome:645557 "mRNA Editing: A to I Conversion" xref: Reactome:655898 "mRNA Editing: A to I Conversion" xref: Reactome:661079 "mRNA Editing: A to I Conversion" xref: Reactome:666862 "mRNA Editing: A to I Conversion" xref: Reactome:672980 "mRNA Editing: A to I Conversion" xref: Reactome:678697 "mRNA Editing: A to I Conversion" xref: Reactome:689860 "mRNA Editing: A to I Conversion" xref: Reactome:701602 "mRNA Editing: A to I Conversion" xref: Reactome:716187 "mRNA Editing: A to I Conversion" xref: Reactome:720757 "mRNA Editing: A to I Conversion" xref: Reactome:75064 "mRNA Editing: A to I Conversion" is_a: GO:0016553 ! base conversion or substitution editing [Term] id: GO:0006383 name: transcription from RNA polymerase III promoter namespace: biological_process def: "The synthesis of RNA from a DNA template by RNA polymerase III (Pol III), originating at a Pol III-specific promoter." [GOC:jl] subset: gosubset_prok synonym: "transcription from Pol III promoter" EXACT [] xref: Reactome:112054 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:112055 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:112149 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:112153 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:112155 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:112156 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:113442 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:113446 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:113451 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:113705 "RNA Polymerase III Productive Transcription" xref: Reactome:553289 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:560132 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:560220 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:560222 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:560224 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:560225 "RNA Polymerase III Productive Transcription" xref: Reactome:560226 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:560229 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:560230 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:560231 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:560232 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:562991 "RNA Polymerase III Transcription" xref: Reactome:579176 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:585907 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:585985 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:585987 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:585989 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:585990 "RNA Polymerase III Productive Transcription" xref: Reactome:585991 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:585994 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:585995 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:585996 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:585997 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:588607 "RNA Polymerase III Transcription" xref: Reactome:602247 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:607033 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:607099 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:607101 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:607103 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:607104 "RNA Polymerase III Productive Transcription" xref: Reactome:607108 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:607114 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:607115 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:607116 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:607117 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:609350 "RNA Polymerase III Transcription" xref: Reactome:626042 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:631432 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:631495 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:631497 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:631499 "RNA Polymerase III Abortive Initiation At Type 3 Open Promoters" xref: Reactome:631500 "RNA Polymerase III Productive Transcription" xref: Reactome:631501 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:631504 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:631505 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:631506 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:631507 "RNA Polymerase III Simple Start Sequence Initiation At Type 3 Promoters" xref: Reactome:634042 "RNA Polymerase III Transcription" xref: Reactome:641616 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:644217 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:644257 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:644259 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:644260 "RNA Polymerase III Productive Transcription" xref: Reactome:644261 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:644263 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:644264 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:644265 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:645576 "RNA Polymerase III Transcription" xref: Reactome:652228 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:654676 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:654735 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:654736 "RNA Polymerase III Productive Transcription" xref: Reactome:654741 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:654742 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:656086 "RNA Polymerase III Transcription" xref: Reactome:659391 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:660490 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:660510 "RNA Polymerase III Productive Transcription" xref: Reactome:660511 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:661092 "RNA Polymerase III Transcription" xref: Reactome:667034 "RNA Polymerase III Transcription" xref: Reactome:671065 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:672305 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:672326 "RNA Polymerase III Productive Transcription" xref: Reactome:672327 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:672992 "RNA Polymerase III Transcription" xref: Reactome:677028 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:678105 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:678139 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:678141 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:678142 "RNA Polymerase III Productive Transcription" xref: Reactome:678146 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:678151 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:678152 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:678153 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:678709 "RNA Polymerase III Transcription" xref: Reactome:682099 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:683032 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:683053 "RNA Polymerase III Productive Transcription" xref: Reactome:683054 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:683802 "RNA Polymerase III Transcription" xref: Reactome:687833 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:689157 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:689179 "RNA Polymerase III Productive Transcription" xref: Reactome:689180 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:690027 "RNA Polymerase III Transcription" xref: Reactome:698437 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:700464 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:700509 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:700511 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:700512 "RNA Polymerase III Productive Transcription" xref: Reactome:700516 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:700521 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:700522 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:700523 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:701615 "RNA Polymerase III Transcription" xref: Reactome:712391 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:714965 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:715007 "RNA Polymerase III Abortive Initiation At Type 1 Open Promoters" xref: Reactome:715009 "RNA Polymerase III Abortive Initiation At Type 2 Open Promoters" xref: Reactome:715010 "RNA Polymerase III Productive Transcription" xref: Reactome:715014 "RNA Polymerase III Promoter Opening at Type 1 Promoters" xref: Reactome:715019 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:715020 "RNA Polymerase III Simple Start Sequence Initiation At Type 1 Promoters" xref: Reactome:715021 "RNA Polymerase III Simple Start Sequence Initiation At Type 2 Promoters" xref: Reactome:716199 "RNA Polymerase III Transcription" xref: Reactome:719442 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:720336 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:720354 "RNA Polymerase III Productive Transcription" xref: Reactome:720355 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:720855 "RNA Polymerase III Transcription" xref: Reactome:725746 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:727409 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:727445 "RNA Polymerase III Productive Transcription" xref: Reactome:727446 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:728148 "RNA Polymerase III Transcription" xref: Reactome:730082 "Initiation of RNA Polymerase III Productive Transcription" xref: Reactome:730608 "Resumption of RNA Polymerase III Productive Transcription" xref: Reactome:730629 "RNA Polymerase III Productive Transcription" xref: Reactome:730630 "RNA Polymerase III Retractive RNase Activity at U-tract Pause Sites" xref: Reactome:731131 "RNA Polymerase III Transcription" xref: Reactome:74158 "RNA Polymerase III Transcription" xref: Reactome:76060 "RNA Polymerase III Promoter Opening at Type 1 Promoters" is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0006384 name: transcription initiation from RNA polymerase III promoter namespace: biological_process def: "A transcription initiation process that results in RNA synthesis by RNA polymerase III." [GOC:mah] synonym: "transcription initiation from Pol III promoter" EXACT [] is_a: GO:0006352 ! transcription initiation relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006385 name: RNA elongation from RNA polymerase III promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation at an RNA polymerase III-specific promoter by the addition of ribonucleotides catalyzed by RNA polymerase III." [GOC:mah] synonym: "RNA elongation from Pol III promoter" EXACT [] xref: Reactome:563247 "RNA Polymerase III Chain Elongation" xref: Reactome:588857 "RNA Polymerase III Chain Elongation" xref: Reactome:609576 "RNA Polymerase III Chain Elongation" xref: Reactome:634282 "RNA Polymerase III Chain Elongation" xref: Reactome:645756 "RNA Polymerase III Chain Elongation" xref: Reactome:656085 "RNA Polymerase III Chain Elongation" xref: Reactome:661260 "RNA Polymerase III Chain Elongation" xref: Reactome:667033 "RNA Polymerase III Chain Elongation" xref: Reactome:673181 "RNA Polymerase III Chain Elongation" xref: Reactome:678872 "RNA Polymerase III Chain Elongation" xref: Reactome:683801 "RNA Polymerase III Chain Elongation" xref: Reactome:690026 "RNA Polymerase III Chain Elongation" xref: Reactome:701800 "RNA Polymerase III Chain Elongation" xref: Reactome:716375 "RNA Polymerase III Chain Elongation" xref: Reactome:720854 "RNA Polymerase III Chain Elongation" xref: Reactome:728308 "RNA Polymerase III Chain Elongation" xref: Reactome:731130 "RNA Polymerase III Chain Elongation" xref: Reactome:73780 "RNA Polymerase III Chain Elongation" is_a: GO:0006354 ! RNA elongation relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006386 name: termination of RNA polymerase III transcription namespace: biological_process alt_id: GO:0019225 def: "The process by which transcription by RNA polymerase III is terminated; Pol III has an intrinsic ability to terminate transcription upon incorporation of 4 to 6 contiguous U residues." [GOC:mah, PMID:12944462] synonym: "RNA polymerase III transcription termination" EXACT [] synonym: "transcription termination from Pol III promoter" EXACT [] synonym: "transcription termination from RNA polymerase III promoter" EXACT [] xref: Reactome:112466 "RNA Polymerase III Transcriptional Pause at Terminator Sequence" xref: Reactome:112480 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:113454 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:560245 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:563374 "RNA Polymerase III Transcription Termination" xref: Reactome:586013 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:588995 "RNA Polymerase III Transcription Termination" xref: Reactome:607125 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:609715 "RNA Polymerase III Transcription Termination" xref: Reactome:631522 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:634412 "RNA Polymerase III Transcription Termination" xref: Reactome:644271 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:645872 "RNA Polymerase III Transcription Termination" xref: Reactome:654748 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:656191 "RNA Polymerase III Transcription Termination" xref: Reactome:660515 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:661331 "RNA Polymerase III Transcription Termination" xref: Reactome:667114 "RNA Polymerase III Transcription Termination" xref: Reactome:672331 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:673257 "RNA Polymerase III Transcription Termination" xref: Reactome:678157 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:678944 "RNA Polymerase III Transcription Termination" xref: Reactome:683058 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:683865 "RNA Polymerase III Transcription Termination" xref: Reactome:689184 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:690118 "RNA Polymerase III Transcription Termination" xref: Reactome:700527 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:701864 "RNA Polymerase III Transcription Termination" xref: Reactome:715030 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:716438 "RNA Polymerase III Transcription Termination" xref: Reactome:720359 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:720941 "RNA Polymerase III Transcription Termination" xref: Reactome:727450 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:728395 "RNA Polymerase III Transcription Termination" xref: Reactome:730632 "RNA Polymerase III Termination and release of transcribed mRNA" xref: Reactome:731180 "RNA Polymerase III Transcription Termination" xref: Reactome:73980 "RNA Polymerase III Transcription Termination" is_a: GO:0006353 ! transcription termination relationship: part_of GO:0006383 ! transcription from RNA polymerase III promoter [Term] id: GO:0006387 name: snRNA capping namespace: biological_process is_a: GO:0009452 ! RNA capping is_a: GO:0016180 ! snRNA processing [Term] id: GO:0006388 name: tRNA splicing, via endonucleolytic cleavage and ligation namespace: biological_process def: "Splicing of tRNA substrates via recognition of the folded RNA structure that brings the 5' and 3' splice sites into proximity and cleavage of the RNA at both the 3' and 5' splice sites by an endonucleolytic mechanism, followed by ligation of the exons." [GOC:krc, ISBN:0879695897, PMID:9582290] comment: Note that while typically associated with tRNA splicing, splicing via endonucleolytic cleavages and subsequent ligation of the free exon ends is known to be used for some non-tRNA substrates, e.g. HAC1 (YFL031W) in S. cerevisiae and an intron in the 23S rRNA of the Archaeal species Desulfurococcus mobilis. subset: gosubset_prok synonym: "tRNA-Y splicing" NARROW [] is_a: GO:0000394 ! RNA splicing, via endonucleolytic cleavage and ligation is_a: GO:0008033 ! tRNA processing [Term] id: GO:0006389 name: tRNA-Y splicing namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it does not represent a process unique to splicing of the tyrosyl (Y) tRNA. is_obsolete: true consider: GO:0006388 [Term] id: GO:0006390 name: transcription from mitochondrial promoter namespace: biological_process def: "The synthesis of RNA from a mitochondrial DNA template, usually by a specific mitochondrial RNA polymerase." [GOC:jl] synonym: "mitochondrial transcription" EXACT [] xref: Reactome:562923 "Transcription from mitochondrial promoters" xref: Reactome:588544 "Transcription from mitochondrial promoters" xref: Reactome:609296 "Transcription from mitochondrial promoters" xref: Reactome:633979 "Transcription from mitochondrial promoters" xref: Reactome:645887 "Transcription from mitochondrial promoters" xref: Reactome:656207 "Transcription from mitochondrial promoters" xref: Reactome:75944 "Transcription from mitochondrial promoters" is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0007005 ! mitochondrion organization [Term] id: GO:0006391 name: transcription initiation from mitochondrial promoter namespace: biological_process def: "A transcription initiation process that takes place at a promoter on the mitochondrial chromosome, and results in RNA synthesis by a mitochondrial RNA polymerase." [GOC:mah] xref: Reactome:163282 "Mitochondrial transcription initiation" xref: Reactome:562934 "Mitochondrial transcription initiation" xref: Reactome:588555 "Mitochondrial transcription initiation" xref: Reactome:609295 "Mitochondrial transcription initiation" xref: Reactome:645886 "Mitochondrial transcription initiation" xref: Reactome:656206 "Mitochondrial transcription initiation" is_a: GO:0006352 ! transcription initiation relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006392 name: RNA elongation from mitochondrial promoter namespace: biological_process def: "The extension of an RNA molecule after transcription initiation at mitochondrial promoter by the addition of ribonucleotides catalyzed by a mitchondrial RNA polymerase." [GOC:mah] is_a: GO:0006354 ! RNA elongation relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006393 name: termination of mitochondrial transcription namespace: biological_process def: "The process by which the synthesis of an RNA molecule using a mitochondrial DNA template is completed." [GOC:mah] synonym: "mitochondrial transcription termination" EXACT [] synonym: "RNA transcription termination from mitochondrial promoter" EXACT [] xref: Reactome:163316 "Mitochondrial transcription termination" xref: Reactome:562922 "Mitochondrial transcription termination" xref: Reactome:588543 "Mitochondrial transcription termination" xref: Reactome:633978 "Mitochondrial transcription termination" is_a: GO:0006353 ! transcription termination relationship: part_of GO:0006390 ! transcription from mitochondrial promoter [Term] id: GO:0006396 name: RNA processing namespace: biological_process alt_id: GO:0006394 def: "Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules." [GOC:mah] subset: goslim_pir subset: gosubset_prok xref: Wikipedia:Post-transcriptional_modification is_a: GO:0016070 ! RNA metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006397 name: mRNA processing namespace: biological_process def: "Any process involved in the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide." [GOC:mah] subset: gosubset_prok synonym: "mRNA maturation" RELATED [] is_a: GO:0006396 ! RNA processing is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006398 name: histone mRNA 3'-end processing namespace: biological_process def: "Any process involved in forming the mature 3' end of a histone mRNA molecule." [GOC:mah] synonym: "histone mRNA 3' end processing" EXACT [] is_a: GO:0008334 ! histone mRNA metabolic process is_a: GO:0031124 ! mRNA 3'-end processing [Term] id: GO:0006399 name: tRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tRNA, transfer RNA, a class of relatively small RNA molecules responsible for mediating the insertion of amino acids into the sequence of nascent polypeptide chains during protein synthesis. Transfer RNA is characterized by the presence of many unusual minor bases, the function of which has not been completely established." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "tRNA metabolism" EXACT [] is_a: GO:0034660 ! ncRNA metabolic process [Term] id: GO:0006400 name: tRNA modification namespace: biological_process alt_id: GO:0016549 def: "The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically." [GOC:curators] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. Parallel changes were made for substrate (e.g. tRNA, rRNA, etc.) specific child terms of 'RNA editing'. subset: gosubset_prok synonym: "tRNA editing" NARROW [GOC:hjd] is_a: GO:0008033 ! tRNA processing is_a: GO:0009451 ! RNA modification [Term] id: GO:0006401 name: RNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "RNA breakdown" EXACT [] synonym: "RNA catabolism" EXACT [] synonym: "RNA degradation" EXACT [] is_a: GO:0016070 ! RNA metabolic process is_a: GO:0044265 ! cellular macromolecule catabolic process [Term] id: GO:0006402 name: mRNA catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mRNA, messenger RNA, which is responsible for carrying the coded genetic 'message', transcribed from DNA, to sites of protein assembly at the ribosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "mRNA breakdown" EXACT [] synonym: "mRNA catabolism" EXACT [] synonym: "mRNA decay" RELATED [GOC:ascb_2010, GOC:dph, GOC:tb] synonym: "mRNA degradation" EXACT [] is_a: GO:0006401 ! RNA catabolic process is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0006403 name: RNA localization namespace: biological_process def: "A process by which RNA is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of RNA localization" EXACT [] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0006404 name: RNA import into nucleus namespace: biological_process def: "The import of RNA from the cytoplasm to the nucleus." [GOC:ma] synonym: "RNA import into cell nucleus" EXACT [] synonym: "RNA transport from cytoplasm to nucleus" EXACT [] synonym: "RNA-nucleus import" EXACT [] is_a: GO:0050658 ! RNA transport is_a: GO:0051170 ! nuclear import [Term] id: GO:0006405 name: RNA export from nucleus namespace: biological_process def: "The directed movement of RNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "RNA export from cell nucleus" EXACT [] synonym: "RNA export out of nucleus" EXACT [] synonym: "RNA transport from nucleus to cytoplasm" EXACT [] synonym: "RNA-nucleus export" EXACT [] xref: Reactome:158441 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:158447 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:158481 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:159101 "Recruitment of TAP to the EJC" xref: Reactome:559752 "Recruitment of TAP to the EJC" xref: Reactome:560085 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:561901 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:561903 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:585511 "Recruitment of TAP to the EJC" xref: Reactome:585867 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:587526 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:587528 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:631054 "Recruitment of TAP to the EJC" xref: Reactome:631393 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:632980 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:632983 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:643947 "Recruitment of TAP to the EJC" xref: Reactome:644196 "Release of the Mature intronless derived mRNA, TAP, and Aly/Ref from the NPC" xref: Reactome:644942 "Transport of the Mature Intronless Transcript Derived Histone mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:644944 "Transport of the Mature intronless transcript derived mRNA:TAP:Aly/Ref Complex through the NPC" xref: Reactome:654413 "Recruitment of TAP to the EJC" is_a: GO:0050658 ! RNA transport is_a: GO:0051168 ! nuclear export [Term] id: GO:0006406 name: mRNA export from nucleus namespace: biological_process def: "The directed movement of mRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "mRNA export from cell nucleus" EXACT [] synonym: "mRNA export out of nucleus" EXACT [] synonym: "mRNA transport from nucleus to cytoplasm" EXACT [] synonym: "mRNA-nucleus export" EXACT [] xref: Reactome:111439 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:158484 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:159046 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:159050 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:159234 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:159236 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:548662 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:548668 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:548672 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:559905 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:560090 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:560094 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:561899 "Transport of the export-competent complex through the NPC" xref: Reactome:561905 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:563135 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:563136 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:563365 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:575460 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:575464 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:585680 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:585871 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:587524 "Transport of the export-competent complex through the NPC" xref: Reactome:588747 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:588748 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:588986 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:608496 "Transport of the export-competent complex through the NPC" xref: Reactome:609741 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:609742 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:631175 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:631399 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:631403 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:632977 "Transport of the export-competent complex through the NPC" xref: Reactome:632987 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:634399 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:634400 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:634405 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:640138 "Docking of Mature Histone mRNA complex:TAP at the NPC" xref: Reactome:640144 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:640148 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" xref: Reactome:644064 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:644201 "Release of the Mature intronless transcript derived Histone mRNA:SLBP:eIF4E Complex" xref: Reactome:644205 "Release of the SLBP independent Histone mRNA from the NPC" xref: Reactome:644940 "Transport of the export-competent complex through the NPC" xref: Reactome:644946 "Transport of the Mature IntronlessTranscript Derived Histone mRNA:SLBP:TAP:Aly/Ref complex through the NPC" xref: Reactome:645685 "Transport of Mature mRNAs Derived from Intronless Transcripts" xref: Reactome:645686 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:645863 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:656180 "Transport of Mature mRNA derived from an Intron-Containing Transcript" xref: Reactome:656181 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:72202 "Transport of Mature Transcript to Cytoplasm" xref: Reactome:75096 "Docking of the TAP:EJC Complex with the NPC" xref: Reactome:75097 "Transport of the export-competent complex through the NPC" xref: Reactome:75098 "Release from the NPC and Disassembly of the mRNP" xref: Reactome:77587 "Docking of Mature Replication Dependent Histone mRNA with the NPC" xref: Reactome:77594 "Docking of the Mature intronless derived transcript derived mRNA, TAP and Aly/Ref at the NPC" is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051028 ! mRNA transport [Term] id: GO:0006407 name: rRNA export from nucleus namespace: biological_process def: "The directed movement of rRNA from the nucleus to the cytoplasm; the rRNA is usually in the form of ribonucleoproteins." [GOC:ma, GOC:mah] synonym: "rRNA export from cell nucleus" EXACT [] synonym: "rRNA export out of nucleus" EXACT [] synonym: "rRNA transport from nucleus to cytoplasm" EXACT [] synonym: "rRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051029 ! rRNA transport relationship: part_of GO:0042254 ! ribosome biogenesis [Term] id: GO:0006408 name: snRNA export from nucleus namespace: biological_process def: "The directed movement of snRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "snRNA export from cell nucleus" EXACT [] synonym: "snRNA export out of nucleus" EXACT [] synonym: "snRNA transport from nucleus to cytoplasm" EXACT [] synonym: "snRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051030 ! snRNA transport [Term] id: GO:0006409 name: tRNA export from nucleus namespace: biological_process def: "The directed movement of tRNA from the nucleus to the cytoplasm." [GOC:ma] synonym: "tRNA export from cell nucleus" EXACT [] synonym: "tRNA export out of nucleus" EXACT [] synonym: "tRNA transport from nucleus to cytoplasm" EXACT [] synonym: "tRNA-nucleus export" EXACT [] is_a: GO:0006405 ! RNA export from nucleus is_a: GO:0051031 ! tRNA transport [Term] id: GO:0006410 name: transcription, RNA-dependent namespace: biological_process def: "The cellular synthesis of DNA on a template of RNA." [GOC:jl] subset: gosubset_prok synonym: "reverse transcription" EXACT [] xref: Wikipedia:Reverse_transcription is_a: GO:0006350 ! transcription [Term] id: GO:0006412 name: translation namespace: biological_process alt_id: GO:0006416 alt_id: GO:0006453 alt_id: GO:0043037 def: "The cellular metabolic process by which a protein is formed, using the sequence of a mature mRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA. Translation ends with the release of a polypeptide chain from the ribosome." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "protein anabolism" EXACT [] synonym: "protein biosynthesis" EXACT [] synonym: "protein biosynthetic process" EXACT [GOC:curators] synonym: "protein formation" EXACT [] synonym: "protein synthesis" EXACT [] synonym: "protein translation" EXACT [] xref: Reactome:562867 "Translation" xref: Reactome:588488 "Translation" xref: Reactome:609228 "Translation" xref: Reactome:633921 "Translation" xref: Reactome:645493 "Translation" xref: Reactome:655854 "Translation" xref: Reactome:661054 "Translation" xref: Reactome:666829 "Translation" xref: Reactome:672940 "Translation" xref: Reactome:678656 "Translation" xref: Reactome:683587 "Translation" xref: Reactome:689823 "Translation" xref: Reactome:701538 "Translation" xref: Reactome:716122 "Translation" xref: Reactome:720729 "Translation" xref: Reactome:72766 "Translation" xref: Reactome:728084 "Translation" xref: Reactome:730987 "Translation" xref: Reactome:733094 "Translation" xref: Reactome:733914 "Translation" xref: Reactome:735677 "Translation" xref: Wikipedia:Translation_(genetics) is_a: GO:0034645 ! cellular macromolecule biosynthetic process is_a: GO:0044267 ! cellular protein metabolic process relationship: part_of GO:0010467 ! gene expression [Term] id: GO:0006413 name: translational initiation namespace: biological_process alt_id: GO:0006440 alt_id: GO:0006454 def: "The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA, and an initiation complex that contains the first aminoacyl-tRNA." [ISBN:019879276X] subset: gosubset_prok synonym: "biopolymerisation" BROAD [] synonym: "biopolymerization" BROAD [] synonym: "protein synthesis initiation" BROAD [] synonym: "translation initiation" EXACT [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006414 name: translational elongation namespace: biological_process alt_id: GO:0006442 alt_id: GO:0006455 def: "The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis." [GOC:ems] subset: gosubset_prok synonym: "protein synthesis elongation" BROAD [] synonym: "translation elongation" EXACT [] xref: Reactome:156842 "Eukaryotic Translation Elongation" xref: Reactome:562866 "Eukaryotic Translation Elongation" xref: Reactome:588487 "Eukaryotic Translation Elongation" xref: Reactome:609227 "Eukaryotic Translation Elongation" xref: Reactome:633920 "Eukaryotic Translation Elongation" xref: Reactome:645492 "Eukaryotic Translation Elongation" xref: Reactome:655853 "Eukaryotic Translation Elongation" xref: Reactome:661053 "Eukaryotic Translation Elongation" xref: Reactome:666828 "Eukaryotic Translation Elongation" xref: Reactome:672939 "Eukaryotic Translation Elongation" xref: Reactome:678655 "Eukaryotic Translation Elongation" xref: Reactome:683586 "Eukaryotic Translation Elongation" xref: Reactome:689822 "Eukaryotic Translation Elongation" xref: Reactome:701537 "Eukaryotic Translation Elongation" xref: Reactome:716121 "Eukaryotic Translation Elongation" xref: Reactome:720728 "Eukaryotic Translation Elongation" xref: Reactome:728083 "Eukaryotic Translation Elongation" xref: Reactome:730986 "Eukaryotic Translation Elongation" xref: Reactome:733098 "Eukaryotic Translation Elongation" xref: Reactome:733916 "Eukaryotic Translation Elongation" xref: Reactome:735676 "Eukaryotic Translation Elongation" is_a: GO:0034645 ! cellular macromolecule biosynthetic process relationship: part_of GO:0006412 ! translation [Term] id: GO:0006415 name: translational termination namespace: biological_process alt_id: GO:0006443 alt_id: GO:0006456 def: "The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code)." [GOC:hjd, ISBN:019879276X] subset: gosubset_prok synonym: "protein synthesis termination" BROAD [] synonym: "translation termination" EXACT [] synonym: "translational complex disassembly" EXACT [] xref: Reactome:141667 "GTP bound eRF3:eRF1 complex binds the peptidyl-tRNA:mRNA:Ribosome complex" xref: Reactome:141671 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:141673 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:141687 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:141691 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:141696 "Eukaryotic Translation Termination" xref: Reactome:141698 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:552838 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:552841 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:559090 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:563227 "Eukaryotic Translation Termination" xref: Reactome:578659 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:578662 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:584738 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:588833 "Eukaryotic Translation Termination" xref: Reactome:601809 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:601812 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:606255 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:609555 "Eukaryotic Translation Termination" xref: Reactome:625557 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:625560 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:630535 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:634261 "Eukaryotic Translation Termination" xref: Reactome:641358 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:641361 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:643693 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:645741 "Eukaryotic Translation Termination" xref: Reactome:651959 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:651962 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:654200 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:656068 "Eukaryotic Translation Termination" xref: Reactome:659222 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:659225 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:660194 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:661245 "Eukaryotic Translation Termination" xref: Reactome:667016 "Eukaryotic Translation Termination" xref: Reactome:670886 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:670889 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:672035 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:673161 "Eukaryotic Translation Termination" xref: Reactome:676872 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:676875 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:677826 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:678860 "Eukaryotic Translation Termination" xref: Reactome:681986 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:681989 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:682827 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:683789 "Eukaryotic Translation Termination" xref: Reactome:687669 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:687672 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:688885 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:690015 "Eukaryotic Translation Termination" xref: Reactome:698110 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:698113 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:699992 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:701785 "Eukaryotic Translation Termination" xref: Reactome:711990 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:711993 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:714337 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:716360 "Eukaryotic Translation Termination" xref: Reactome:719309 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:719312 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:720037 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:720842 "Eukaryotic Translation Termination" xref: Reactome:725511 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:725514 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:727018 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:72764 "Eukaryotic Translation Termination" xref: Reactome:728296 "Eukaryotic Translation Termination" xref: Reactome:729993 "GTP bound eRF3:eRF1 complex binds the peptidyl tRNA:mRNA:80S Ribosome complex" xref: Reactome:729996 "GTP Hydrolysis by eRF3 bound to the eRF1:mRNA:polypeptide:80S Ribosome complex" xref: Reactome:730487 "Polypeptide release from the eRF3-GDP:eRF1:mRNA:80S Ribosome complex" xref: Reactome:731122 "Eukaryotic Translation Termination" is_a: GO:0043624 ! cellular protein complex disassembly relationship: part_of GO:0006412 ! translation [Term] id: GO:0006417 name: regulation of translation namespace: biological_process alt_id: GO:0006445 def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of proteins by the translation of mRNA." [GOC:isa_complete] subset: gosubset_prok synonym: "regulation of protein anabolism" EXACT [] synonym: "regulation of protein biosynthesis" EXACT [] synonym: "regulation of protein formation" EXACT [] synonym: "regulation of protein synthesis" EXACT [] is_a: GO:0010556 ! regulation of macromolecule biosynthetic process is_a: GO:0010608 ! posttranscriptional regulation of gene expression is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0032268 ! regulation of cellular protein metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006412 ! translation relationship: regulates GO:0006412 ! translation [Term] id: GO:0006418 name: tRNA aminoacylation for protein translation namespace: biological_process def: "The synthesis of aminoacyl tRNA by the formation of an ester bond between the 3'-hydroxyl group of the most 3' adenosine of the tRNA, to be used in ribosome-mediated polypeptide synthesis." [GOC:ma] subset: gosubset_prok synonym: "tRNA charging" NARROW [] xref: MetaCyc:TRNA-CHARGING-PWY xref: Reactome:379716 "Cytosolic tRNA aminoacylation" xref: Reactome:379724 "tRNA Aminoacylation" xref: Reactome:379726 "Mitochondrial tRNA aminoacylation" xref: Reactome:562852 "Cytosolic tRNA aminoacylation" xref: Reactome:562853 "tRNA Aminoacylation" xref: Reactome:562854 "Mitochondrial tRNA aminoacylation" xref: Reactome:588472 "Cytosolic tRNA aminoacylation" xref: Reactome:588473 "tRNA Aminoacylation" xref: Reactome:588474 "Mitochondrial tRNA aminoacylation" xref: Reactome:609213 "Cytosolic tRNA aminoacylation" xref: Reactome:609214 "tRNA Aminoacylation" xref: Reactome:609215 "Mitochondrial tRNA aminoacylation" xref: Reactome:633906 "Cytosolic tRNA aminoacylation" xref: Reactome:633907 "tRNA Aminoacylation" xref: Reactome:633908 "Mitochondrial tRNA aminoacylation" xref: Reactome:645483 "Cytosolic tRNA aminoacylation" xref: Reactome:645484 "tRNA Aminoacylation" xref: Reactome:645485 "Mitochondrial tRNA aminoacylation" xref: Reactome:655844 "Cytosolic tRNA aminoacylation" xref: Reactome:655845 "tRNA Aminoacylation" xref: Reactome:655846 "Mitochondrial tRNA aminoacylation" xref: Reactome:661041 "Cytosolic tRNA aminoacylation" xref: Reactome:661042 "tRNA Aminoacylation" xref: Reactome:661044 "Mitochondrial tRNA aminoacylation" xref: Reactome:666818 "Cytosolic tRNA aminoacylation" xref: Reactome:666819 "tRNA Aminoacylation" xref: Reactome:666820 "Mitochondrial tRNA aminoacylation" xref: Reactome:672929 "Cytosolic tRNA aminoacylation" xref: Reactome:672930 "tRNA Aminoacylation" xref: Reactome:672931 "Mitochondrial tRNA aminoacylation" xref: Reactome:678642 "Cytosolic tRNA aminoacylation" xref: Reactome:678643 "tRNA Aminoacylation" xref: Reactome:678644 "Mitochondrial tRNA aminoacylation" xref: Reactome:683575 "Cytosolic tRNA aminoacylation" xref: Reactome:683576 "tRNA Aminoacylation" xref: Reactome:683577 "Mitochondrial tRNA aminoacylation" xref: Reactome:689811 "Cytosolic tRNA aminoacylation" xref: Reactome:689812 "tRNA Aminoacylation" xref: Reactome:689813 "Mitochondrial tRNA aminoacylation" xref: Reactome:701526 "Cytosolic tRNA aminoacylation" xref: Reactome:701527 "tRNA Aminoacylation" xref: Reactome:701528 "Mitochondrial tRNA aminoacylation" xref: Reactome:716110 "Cytosolic tRNA aminoacylation" xref: Reactome:716111 "tRNA Aminoacylation" xref: Reactome:716112 "Mitochondrial tRNA aminoacylation" xref: Reactome:720720 "Cytosolic tRNA aminoacylation" xref: Reactome:720721 "tRNA Aminoacylation" xref: Reactome:720723 "Mitochondrial tRNA aminoacylation" xref: Reactome:728074 "Cytosolic tRNA aminoacylation" xref: Reactome:728075 "tRNA Aminoacylation" xref: Reactome:728076 "Mitochondrial tRNA aminoacylation" xref: Reactome:730975 "Cytosolic tRNA aminoacylation" xref: Reactome:730976 "tRNA Aminoacylation" xref: Reactome:730977 "Mitochondrial tRNA aminoacylation" xref: Reactome:733041 "Cytosolic tRNA aminoacylation" xref: Reactome:733042 "tRNA Aminoacylation" xref: Reactome:733044 "Mitochondrial tRNA aminoacylation" xref: Reactome:733886 "Cytosolic tRNA aminoacylation" xref: Reactome:733887 "tRNA Aminoacylation" xref: Reactome:733889 "Mitochondrial tRNA aminoacylation" xref: Reactome:735604 "Cytosolic tRNA aminoacylation" xref: Reactome:735605 "tRNA Aminoacylation" xref: Reactome:735607 "Mitochondrial tRNA aminoacylation" xref: Reactome:736556 "Cytosolic tRNA aminoacylation" xref: Reactome:736557 "tRNA Aminoacylation" xref: Reactome:736559 "Mitochondrial tRNA aminoacylation" xref: Reactome:738516 "Cytosolic tRNA aminoacylation" xref: Reactome:738517 "tRNA Aminoacylation" xref: Reactome:738519 "Mitochondrial tRNA aminoacylation" is_a: GO:0043039 ! tRNA aminoacylation relationship: part_of GO:0006412 ! translation [Term] id: GO:0006419 name: alanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling alanine to alanyl-tRNA, catalyzed by alanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006420 name: arginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling arginine to arginyl-tRNA, catalyzed by arginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006421 name: asparaginyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling asparagine to asparaginyl-tRNA, catalyzed by asparaginyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006422 name: aspartyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling aspartate to aspartyl-tRNA, catalyzed by aspartyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006423 name: cysteinyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling cysteine to cysteinyl-tRNA, catalyzed by cysteinyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006424 name: glutamyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamate to glutamyl-tRNA, catalyzed by glutamyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006425 name: glutaminyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glutamine to glutaminyl-tRNA, catalyzed by glutaminyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'- adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006426 name: glycyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006427 name: histidyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling histidine to histidyl-tRNA, catalyzed by histidyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006428 name: isoleucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling isoleucine to isoleucyl-tRNA, catalyzed by isoleucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006429 name: leucyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006430 name: lysyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling lysine to lysyl-tRNA, catalyzed by lysyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006431 name: methionyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling methionine to methionyl-tRNA, catalyzed by methionyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006432 name: phenylalanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006433 name: prolyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling proline to prolyl-tRNA, catalyzed by prolyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mah, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006434 name: seryl-tRNA aminoacylation namespace: biological_process def: "The process of coupling serine to seryl-tRNA, catalyzed by seryl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006435 name: threonyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling threonine to threonyl-tRNA, catalyzed by threonyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006436 name: tryptophanyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006437 name: tyrosyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling tyrosine to tyrosyl-tRNA, catalyzed by tyrosyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006438 name: valyl-tRNA aminoacylation namespace: biological_process def: "The process of coupling valine to valyl-tRNA, catalyzed by valyl-tRNA synthetase. In tRNA aminoacylation, the amino acid is first activated by linkage to AMP and then transferred to either the 2'- or the 3'-hydroxyl group of the 3'-adenosine residue of the tRNA." [GOC:mcc, ISBN:0716730510] subset: gosubset_prok is_a: GO:0006418 ! tRNA aminoacylation for protein translation [Term] id: GO:0006439 name: aminoacyl-tRNA hydrolase reaction namespace: biological_process def: "OBSOLETE. Hydrolysis of the peptidyl-tRNA by aminoacyl-tRNA hydrolase upon termination of translation. Analogous to usual peptidyl transfer during elongation, except that the acceptor is H2O instead of an aminoacyl-tRNA." [ISBN:019879276X] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004045 [Term] id: GO:0006441 name: binding to mRNA cap namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0000339 [Term] id: GO:0006446 name: regulation of translational initiation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational initiation." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006413 ! translational initiation relationship: regulates GO:0006413 ! translational initiation [Term] id: GO:0006447 name: regulation of translational initiation by iron namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the translation of certain mRNAs involved in iron metabolism; regulated by the concentration of iron." [GOC:jl] subset: gosubset_prok is_a: GO:0006446 ! regulation of translational initiation [Term] id: GO:0006448 name: regulation of translational elongation namespace: biological_process def: "Any process that modulates the frequency, rate, extent or accuracy of translational elongation." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006414 ! translational elongation relationship: regulates GO:0006414 ! translational elongation [Term] id: GO:0006449 name: regulation of translational termination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of translational termination." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation is_a: GO:0043244 ! regulation of protein complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006415 ! translational termination relationship: regulates GO:0006415 ! translational termination [Term] id: GO:0006450 name: regulation of translational fidelity namespace: biological_process alt_id: GO:0000029 def: "Any process that modulates the ability of the translational apparatus to interpret the genetic code." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of translational accuracy" EXACT [] is_a: GO:0006448 ! regulation of translational elongation is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0006451 name: translational readthrough namespace: biological_process def: "The continuation of translation beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons." [GOC:jsg] subset: gosubset_prok synonym: "natural nonsense suppression" RELATED [] is_a: GO:0006414 ! translational elongation is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006452 name: translational frameshifting namespace: biological_process def: "A mechanism whereby different proteins may result from a single mRNA molecule, due to a change in the parsing of three nucleotides per codon relative to an initiating AUG codon." [GOC:hjd, ISBN:0195094425] subset: gosubset_prok xref: Wikipedia:Translational_frameshift is_a: GO:0006417 ! regulation of translation [Term] id: GO:0006457 name: protein folding namespace: biological_process alt_id: GO:0007022 alt_id: GO:0007024 alt_id: GO:0007025 def: "The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure." [GOC:go_curators, GOC:rb] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "alpha-tubulin folding" NARROW [GOC:mah] synonym: "beta-tubulin folding" NARROW [GOC:mah] synonym: "chaperone activity" RELATED [] synonym: "chaperonin ATPase activity" RELATED [] synonym: "chaperonin-mediated tubulin folding" NARROW [GOC:mah] synonym: "co-chaperone activity" RELATED [] synonym: "co-chaperonin activity" RELATED [] synonym: "glycoprotein-specific chaperone activity" RELATED [] synonym: "non-chaperonin molecular chaperone ATPase activity" RELATED [] synonym: "protein complex assembly, multichaperone pathway" RELATED [] xref: Reactome:389960 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:389967 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:390466 "Chaperonin-mediated protein folding" xref: Reactome:392033 "Cooperation of Prefoldin and TriC/CCT in actin and tubulin folding" xref: Reactome:562669 "Chaperonin-mediated protein folding" xref: Reactome:562838 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:588294 "Chaperonin-mediated protein folding" xref: Reactome:588458 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:609194 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:609196 "Chaperonin-mediated protein folding" xref: Reactome:633727 "Chaperonin-mediated protein folding" xref: Reactome:633890 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:645341 "Chaperonin-mediated protein folding" xref: Reactome:645470 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:655715 "Chaperonin-mediated protein folding" xref: Reactome:655833 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:661021 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:661023 "Chaperonin-mediated protein folding" xref: Reactome:666760 "Chaperonin-mediated protein folding" xref: Reactome:666803 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:672868 "Chaperonin-mediated protein folding" xref: Reactome:672914 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:678582 "Chaperonin-mediated protein folding" xref: Reactome:678628 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:683539 "Chaperonin-mediated protein folding" xref: Reactome:683568 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:689746 "Chaperonin-mediated protein folding" xref: Reactome:689798 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:701477 "Chaperonin-mediated protein folding" xref: Reactome:701509 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:716048 "Chaperonin-mediated protein folding" xref: Reactome:716095 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:720706 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:720708 "Chaperonin-mediated protein folding" xref: Reactome:727999 "Chaperonin-mediated protein folding" xref: Reactome:728061 "Formation of tubulin folding intermediates by CCT/TriC" xref: Reactome:730929 "Chaperonin-mediated protein folding" xref: Reactome:730967 "Formation of tubulin folding intermediates by CCT/TriC" xref: Wikipedia:Protein_folding is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006458 name: 'de novo' protein folding namespace: biological_process def: "The process of assisting in the folding of a nascent peptide chain into its correct tertiary structure." [GOC:mb] subset: gosubset_prok synonym: "nascent chain protein folding" EXACT [] is_a: GO:0006457 ! protein folding [Term] id: GO:0006459 name: binding unfolded ER proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0005783 consider: GO:0051082 [Term] id: GO:0006460 name: peptidyl-prolyl isomerase B reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0003755 [Term] id: GO:0006461 name: protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex." [GOC:ai] subset: goslim_pombe subset: gosubset_prok synonym: "chaperone activity" RELATED [] synonym: "protein complex biosynthesis" EXACT [] synonym: "protein complex formation" EXACT [] is_a: GO:0065003 ! macromolecular complex assembly relationship: part_of GO:0070271 ! protein complex biogenesis [Term] id: GO:0006462 name: protein complex assembly, multichaperone pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the string was ambiguous and the original meaning of the term was hence unknown. is_obsolete: true consider: GO:0006457 consider: GO:0051131 [Term] id: GO:0006463 name: steroid hormone receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a steroid hormone receptor complex, an intracellular receptor that binds steroid hormones. The complex is often a dimer, and forms after the steroid has bound the receptor." [GOC:jl, Wikipedia:Steroid_hormone_receptor] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0006464 name: protein modification process namespace: biological_process def: "The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification)." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "process resulting in protein modification" RELATED [] synonym: "protein tagging activity" RELATED [] xref: Reactome:163841 "Post-translational protein modification" xref: Reactome:562539 "Post-translational protein modification" xref: Reactome:588165 "Post-translational protein modification" xref: Reactome:608933 "Post-translational protein modification" xref: Reactome:633615 "Post-translational protein modification" xref: Reactome:645242 "Post-translational protein modification" xref: Reactome:655618 "Post-translational protein modification" xref: Reactome:660902 "Post-translational protein modification" xref: Reactome:666686 "Post-translational protein modification" xref: Reactome:672775 "Post-translational protein modification" xref: Reactome:678503 "Post-translational protein modification" xref: Reactome:683750 "Post-translational protein modification" xref: Reactome:689651 "Post-translational protein modification" xref: Reactome:701393 "Post-translational protein modification" xref: Reactome:715964 "Post-translational protein modification" xref: Reactome:720643 "Post-translational protein modification" xref: Reactome:727913 "Post-translational protein modification" xref: Reactome:730892 "Post-translational protein modification" xref: Reactome:733100 "Post-translational protein modification" xref: Reactome:733918 "Post-translational protein modification" is_a: GO:0043412 ! macromolecule modification is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0006465 name: signal peptide processing namespace: biological_process def: "The proteolytic removal of a signal peptide from a protein during or after transport to a specific location in the cell." [GOC:mah, ISBN:0815316194] subset: gosubset_prok synonym: "leader peptide processing" EXACT [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0044267 ! cellular protein metabolic process is_a: GO:0051605 ! protein maturation by peptide bond cleavage [Term] id: GO:0006466 name: protein disulfide-isomerase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it presents a molecular function. synonym: "protein disulphide-isomerase reaction" EXACT [] is_obsolete: true replaced_by: GO:0003756 [Term] id: GO:0006467 name: protein thiol-disulfide exchange namespace: biological_process def: "Oxidation of two organic sulfhydryl groups (thiols) by a disulfide compound to form a disulfide bond." [GOC:jsg] subset: gosubset_prok synonym: "disulphide bond biosynthesis" EXACT [] synonym: "disulphide bond formation" EXACT [] synonym: "protein thiol-disulphide exchange" EXACT [] is_a: GO:0006457 ! protein folding is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0006468 name: protein amino acid phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a protein." [GOC:hb] subset: gosubset_prok is_a: GO:0016310 ! phosphorylation is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0006469 name: negative regulation of protein kinase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of protein kinase activity." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of protein kinase activity" EXACT [] synonym: "down-regulation of protein kinase activity" EXACT [] synonym: "downregulation of protein kinase activity" EXACT [] synonym: "inhibition of protein kinase activity" NARROW [] is_a: GO:0033673 ! negative regulation of kinase activity is_a: GO:0045859 ! regulation of protein kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004672 ! protein kinase activity relationship: negatively_regulates GO:0004672 ! protein kinase activity [Term] id: GO:0006470 name: protein amino acid dephosphorylation namespace: biological_process def: "The process of removing one or more phosphoric residues from a protein." [GOC:hb] subset: gosubset_prok is_a: GO:0016311 ! dephosphorylation is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0006471 name: protein amino acid ADP-ribosylation namespace: biological_process def: "The transfer, from NAD, of ADP-ribose to protein amino acids." [RESID:AA0040, RESID:AA0168, RESID:AA0169, RESID:AA0231, RESID:AA0237, RESID:AA0295] subset: gosubset_prok xref: RESID:AA0040 xref: RESID:AA0168 xref: RESID:AA0169 xref: RESID:AA0231 xref: RESID:AA0237 xref: RESID:AA0295 is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0006473 name: protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok is_a: GO:0043543 ! protein amino acid acylation [Term] id: GO:0006474 name: N-terminal protein amino acid acetylation namespace: biological_process def: "The acetylation of the N-terminal amino acid of proteins." [GOC:ai] subset: gosubset_prok synonym: "N(alpha)-terminal acetylation" NARROW [PMID:11013267] is_a: GO:0006473 ! protein amino acid acetylation is_a: GO:0018409 ! peptide or protein amino-terminal blocking [Term] id: GO:0006475 name: internal protein amino acid acetylation namespace: biological_process def: "The addition of an acetyl group to a non-terminal amino acid in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006473 ! protein amino acid acetylation [Term] id: GO:0006476 name: protein amino acid deacetylation namespace: biological_process def: "The removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid." [GOC:ai] subset: gosubset_prok is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0006477 name: protein amino acid sulfation namespace: biological_process def: "The addition of a sulfate group as an ester to a protein amino acid." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "protein amino acid sulphation" EXACT [] is_a: GO:0043687 ! post-translational protein modification is_a: GO:0051923 ! sulfation [Term] id: GO:0006478 name: peptidyl-tyrosine sulfation namespace: biological_process def: "The posttranslational sulfation of peptidyl-tyrosine residues to form peptidyl-O4'-sulfo-L-tyrosine." [RESID:AA0172] subset: gosubset_prok synonym: "peptidyl-tyrosine sulphation" EXACT [] xref: RESID:AA0172 is_a: GO:0006477 ! protein amino acid sulfation is_a: GO:0018212 ! peptidyl-tyrosine modification [Term] id: GO:0006479 name: protein amino acid methylation namespace: biological_process def: "The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:ai] subset: gosubset_prok is_a: GO:0008213 ! protein amino acid alkylation is_a: GO:0043414 ! macromolecule methylation [Term] id: GO:0006480 name: N-terminal protein amino acid methylation namespace: biological_process def: "The methylation of the N-terminal amino acid of a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0006479 ! protein amino acid methylation is_a: GO:0018409 ! peptide or protein amino-terminal blocking [Term] id: GO:0006481 name: C-terminal protein amino acid methylation namespace: biological_process def: "The methylation of the C-terminal amino acid of a protein." [GOC:ai] subset: gosubset_prok is_a: GO:0006479 ! protein amino acid methylation is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking [Term] id: GO:0006482 name: protein amino acid demethylation namespace: biological_process def: "The removal of a methyl group, from a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom." [GOC:mah] subset: gosubset_prok is_a: GO:0008214 ! protein amino acid dealkylation is_a: GO:0070988 ! demethylation [Term] id: GO:0006483 name: peptidyl-aspartic acid/asparagine hydroxylation namespace: biological_process def: "OBSOLETE. The hydroxylation of peptidyl-aspartic acid or asparagine." [GOC:ai] comment: This term was made obsolete because it is a redundant grouping term. synonym: "aspartic acid/asparagine hydroxylation" EXACT [] is_obsolete: true consider: GO:0042264 consider: GO:0042265 [Term] id: GO:0006484 name: protein cysteine-thiol oxidation namespace: biological_process def: "OBSOLETE. Oxidation of two cysteine sulfhydryl groups (thiols) in one protein by a disulfide bond in a second protein to form a disulfide bond in the first protein and two reduced sulfhydryls in the second. The oxidized cysteines linked by a disulfide bond is known as cystine." [http://micro.magnet.fsu.edu/aminoacids/pages/cystine.html, http://www.indstate.edu/thcme/mwking/pentose-phosphate-pathway.html, RESID:AA0025] comment: This term was made obsolete because it represents a single activity. is_obsolete: true consider: GO:0003756 [Term] id: GO:0006486 name: protein amino acid glycosylation namespace: biological_process def: "A protein modification process that results in the addition of a sugar unit to a protein amino acid, e.g. the addition of glycan chains to proteins." [http://cancerweb.ncl.ac.uk/] subset: goslim_pombe subset: gosubset_prok is_a: GO:0006464 ! protein modification process is_a: GO:0043413 ! macromolecule glycosylation is_a: GO:0044262 ! cellular carbohydrate metabolic process relationship: part_of GO:0009101 ! glycoprotein biosynthetic process [Term] id: GO:0006487 name: protein amino acid N-linked glycosylation namespace: biological_process def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan." [RESID:AA0151, RESID:AA0156, RESID:AA0327] subset: gosubset_prok synonym: "N-glycan biosynthesis" RELATED [] synonym: "N-glycan metabolism" RELATED [] xref: RESID:AA0151 xref: RESID:AA0156 xref: RESID:AA0327 is_a: GO:0006486 ! protein amino acid glycosylation [Term] id: GO:0006488 name: dolichol-linked oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichol-linked oligosaccharide, usually by a stepwise addition of glycosyl chains to endoplasmic reticulum membrane-bound dolichol-P." [GOC:jl, ISBN:0471331309 "Biochemical Pathways"] subset: gosubset_prok synonym: "dolichol-linked oligosaccharide anabolism" EXACT [] synonym: "dolichol-linked oligosaccharide biosynthesis" EXACT [] synonym: "dolichol-linked oligosaccharide formation" EXACT [] synonym: "dolichol-linked oligosaccharide synthesis" EXACT [] synonym: "N-linked glycan precursor biosynthesis" EXACT [PMID:8666161] synonym: "N-linked glycan precursor biosynthetic process" EXACT [PMID:8666161] synonym: "oligosaccharide-PP-dolichol assembly" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process relationship: part_of GO:0006487 ! protein amino acid N-linked glycosylation [Term] id: GO:0006489 name: dolichyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dolichyl diphosphate, a diphosphorylated dolichol derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "dolichyl diphosphate anabolism" EXACT [] synonym: "dolichyl diphosphate biosynthesis" EXACT [] synonym: "dolichyl diphosphate formation" EXACT [] synonym: "dolichyl diphosphate synthesis" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0019408 ! dolichol biosynthetic process is_a: GO:0046465 ! dolichyl diphosphate metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006490 name: oligosaccharide-lipid intermediate assembly namespace: biological_process def: "The cellular metabolic process by which an intermediate molecule of dolichol-P-man or dolicol-P-Glc is assembled to be used in N-linked glycosylation." [GOC:dph, GOC:hjd, GOC:isa_complete] subset: gosubset_prok is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0051691 ! cellular oligosaccharide metabolic process relationship: part_of GO:0006488 ! dolichol-linked oligosaccharide biosynthetic process [Term] id: GO:0006491 name: N-glycan processing namespace: biological_process alt_id: GO:0006492 def: "The conversion of N-linked glycan (N = nitrogen) structures from the initially transferred oligosaccharide to a mature form, by the actions of glycosidases and glycosyltransferases. The early processing steps are conserved and play roles in glycoprotein folding and trafficking." [ISBN:0879695595, PMID:12736198] subset: gosubset_prok synonym: "N-glycan catabolism" RELATED [] synonym: "N-glycan degradation" RELATED [] synonym: "N-linked glycoprotein maturation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process relationship: part_of GO:0006487 ! protein amino acid N-linked glycosylation [Term] id: GO:0006493 name: protein amino acid O-linked glycosylation namespace: biological_process def: "A protein amino acid glycosylation process in which a sugar unit is added to a protein via the hydroxyl group of peptidyl-serine, peptidyl-threonine, peptidyl-hydroxylysine, or peptidyl-hydroxyproline, or via the phenol group of peptidyl-tyrosine, forming an O-glycan." [ISBN:0879695595, RESID:AA0153, RESID:AA0154, RESID:AA0155, RESID:AA0157, RESID:AA0212] subset: gosubset_prok xref: RESID:AA0153 xref: RESID:AA0154 xref: RESID:AA0155 xref: RESID:AA0157 xref: RESID:AA0212 is_a: GO:0006486 ! protein amino acid glycosylation [Term] id: GO:0006494 name: protein amino acid terminal glycosylation namespace: biological_process def: "A protein amino acid glycosylation process in which a sugar unit is added to a free alpha-amino or alpha-carboxyl terminal of a peptide." [GOC:jsg] subset: gosubset_prok is_a: GO:0006486 ! protein amino acid glycosylation [Term] id: GO:0006495 name: terminal O-glycosylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators, GOC:jsg] comment: This term was made obsolete because there is no evidence for the existence of this process. is_obsolete: true [Term] id: GO:0006496 name: protein amino acid terminal N-glycosylation namespace: biological_process def: "The glycosylation of a nitrogen atom of a free alpha amino terminal of a peptide." [GOC:jsg] comment: Note that the only known alpha amino glycosylation is on an asparagine; see UniProtKB:P58522. However, this feature is not differentiated from normal N-glycosylation of asparagine. subset: gosubset_prok is_a: GO:0006487 ! protein amino acid N-linked glycosylation is_a: GO:0006494 ! protein amino acid terminal glycosylation [Term] id: GO:0006497 name: protein amino acid lipidation namespace: biological_process alt_id: GO:0042050 def: "The covalent or non-covalent attachment of lipid moieties to an amino acid in a protein." [GOC:jl] subset: gosubset_prok synonym: "lipid:protein modification" EXACT [] synonym: "protein lipidation" EXACT [] xref: RESID:AA0059 xref: RESID:AA0060 xref: RESID:AA0077 xref: RESID:AA0078 xref: RESID:AA0079 xref: RESID:AA0080 xref: RESID:AA0102 xref: RESID:AA0103 xref: RESID:AA0104 xref: RESID:AA0106 xref: RESID:AA0107 xref: RESID:AA0158 xref: RESID:AA0159 xref: RESID:AA0160 xref: RESID:AA0161 xref: RESID:AA0162 xref: RESID:AA0163 xref: RESID:AA0166 xref: RESID:AA0223 xref: RESID:AA0290 xref: RESID:AA0307 xref: RESID:AA0308 xref: RESID:AA0309 xref: RESID:AA0316 is_a: GO:0006464 ! protein modification process relationship: part_of GO:0042158 ! lipoprotein biosynthetic process [Term] id: GO:0006498 name: N-terminal protein lipidation namespace: biological_process def: "The covalent or non-covalent attachment of a lipid moiety to the amino terminus of a protein." [GOC:jl] subset: gosubset_prok is_a: GO:0006497 ! protein amino acid lipidation is_a: GO:0018409 ! peptide or protein amino-terminal blocking [Term] id: GO:0006499 name: N-terminal protein myristoylation namespace: biological_process def: "The covalent or non-covalent attachment of a myristoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018319 ! protein amino acid myristoylation [Term] id: GO:0006500 name: N-terminal protein palmitoylation namespace: biological_process def: "The covalent or non-covalent attachment of a palmitoyl moiety to the N-terminal amino acid residue of a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0006498 ! N-terminal protein lipidation is_a: GO:0018318 ! protein amino acid palmitoylation [Term] id: GO:0006501 name: C-terminal protein lipidation namespace: biological_process def: "The covalent or non-covalent attachment of a lipid moiety to the carboxy terminus of a protein." [GOC:jl] subset: gosubset_prok xref: Reactome:163125 "Synthesis of GPI-anchored proteins" xref: Reactome:562538 "Synthesis of GPI-anchored proteins" xref: Reactome:588164 "Synthesis of GPI-anchored proteins" xref: Reactome:608932 "Synthesis of GPI-anchored proteins" xref: Reactome:633614 "Synthesis of GPI-anchored proteins" xref: Reactome:645241 "Synthesis of GPI-anchored proteins" xref: Reactome:655617 "Synthesis of GPI-anchored proteins" xref: Reactome:660901 "Synthesis of GPI-anchored proteins" xref: Reactome:666685 "Synthesis of GPI-anchored proteins" xref: Reactome:672774 "Synthesis of GPI-anchored proteins" xref: Reactome:678502 "Synthesis of GPI-anchored proteins" xref: Reactome:689650 "Synthesis of GPI-anchored proteins" xref: Reactome:701392 "Synthesis of GPI-anchored proteins" xref: Reactome:715963 "Synthesis of GPI-anchored proteins" xref: Reactome:720642 "Synthesis of GPI-anchored proteins" xref: Reactome:727912 "Synthesis of GPI-anchored proteins" xref: Reactome:730891 "Synthesis of GPI-anchored proteins" is_a: GO:0006497 ! protein amino acid lipidation is_a: GO:0018410 ! peptide or protein carboxyl-terminal blocking [Term] id: GO:0006502 name: C-terminal protein prenylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a prenyl moiety to the carboxy terminus of a protein; geranyl, farnesyl, or geranylgeranyl groups may be added." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018346 [Term] id: GO:0006503 name: C-terminal protein farnesylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a farnesyl moiety to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018347 [Term] id: GO:0006504 name: C-terminal protein geranylgeranylation namespace: biological_process def: "OBSOLETE. The covalent or non-covalent attachment of a geranylgeranyl moiety to the carboxy terminus of a protein." [GOC:jl] comment: This term was made obsolete because the process is not exclusive to the carboxy terminus of a protein. is_obsolete: true replaced_by: GO:0018348 [Term] id: GO:0006505 name: GPI anchor metabolic process namespace: biological_process alt_id: GO:0046472 def: "The chemical reactions and pathways involving glycosylphosphatidylinositol anchors, molecular mechanisms for attaching membrane proteins to the lipid bilayer of cell membranes. Structurally they consist of a molecule of phosphatidylinositol to which is linked, via the C-6 hydroxyl of the inositol, a carbohydrate chain. This chain is in turn linked to the protein through an ethanolamine phosphate moiety, the amino group of which is in amide linkage with the C-terminal carboxyl of the protein chain, the phosphate group being esterified to the C-6 hydroxyl of the terminal mannose of the core carbohydrate chain." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycosylphosphatidylinositol metabolic process" EXACT [] synonym: "glycosylphosphatidylinositol metabolism" EXACT [] synonym: "GPI anchor metabolism" EXACT [] synonym: "GPI/GSI anchor metabolic process" BROAD [] synonym: "GPI/GSI anchor metabolism" BROAD [] is_a: GO:0030384 ! phosphoinositide metabolic process [Term] id: GO:0006506 name: GPI anchor biosynthetic process namespace: biological_process alt_id: GO:0015998 def: "The chemical reactions and pathways resulting in the formation of a glycosylphosphatidylinositol (GPI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The phosphatidylinositol moiety is linked via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via an ethanolamine phosphate moiety, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GPI anchors have variants on this canonical linkage." [GOC:go_curators, ISBN:0198547684] subset: gosubset_prok synonym: "glycosylphosphatidylinositol biosynthesis" EXACT [] synonym: "glycosylphosphatidylinositol biosynthetic process" EXACT [] synonym: "GPI anchor anabolism" EXACT [] synonym: "GPI anchor biosynthesis" EXACT [] synonym: "GPI anchor formation" EXACT [] synonym: "GPI anchor synthesis" EXACT [] synonym: "GPI/GSI anchor biosynthesis" BROAD [] synonym: "GPI/GSI anchor biosynthetic process" BROAD [] is_a: GO:0006497 ! protein amino acid lipidation is_a: GO:0006505 ! GPI anchor metabolic process is_a: GO:0046489 ! phosphoinositide biosynthetic process [Term] id: GO:0006507 name: GPI anchor release namespace: biological_process subset: gosubset_prok is_a: GO:0006505 ! GPI anchor metabolic process [Term] id: GO:0006508 name: proteolysis namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with the hydrolysis of peptide bonds." [GOC:jsg, GOC:mah] subset: goslim_pir subset: gosubset_prok synonym: "ATP-dependent proteolysis" NARROW [GOC:mah] synonym: "peptidolysis" EXACT [] xref: Reactome:159782 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:563351 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:588968 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:609692 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:634380 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Reactome:645849 "Removal of aminoterminal propeptides from gamma-carboxylated proteins" xref: Wikipedia:Proteolysis is_a: GO:0019538 ! protein metabolic process [Term] id: GO:0006509 name: membrane protein ectodomain proteolysis namespace: biological_process def: "The proteolytic cleavage of transmembrane proteins and release of their ectodomain (extracellular domain)." [GOC:jl, http://www.copewithcytokines.de/] subset: gosubset_prok synonym: "membrane protein solubilization" RELATED [] synonym: "receptor shedding" RELATED [] is_a: GO:0033619 ! membrane protein proteolysis [Term] id: GO:0006510 name: ATP-dependent proteolysis namespace: biological_process def: "OBSOLETE. The hydrolysis of a peptide bond or bonds within a protein using energy from the hydrolysis of ATP." [GOC:jl] comment: This term was made obsolete because it represents a molecular function. synonym: "ATP-dependent peptidolysis" EXACT [] is_obsolete: true replaced_by: GO:0004176 consider: GO:0006508 consider: GO:0051603 consider: GO:0051605 [Term] id: GO:0006511 name: ubiquitin-dependent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of a ubiquitin moiety, or multiple ubiquitin moieties, to the protein." [GOC:go_curators] synonym: "ubiquitin-dependent protein breakdown" EXACT [] synonym: "ubiquitin-dependent protein catabolism" EXACT [] synonym: "ubiquitin-dependent protein degradation" EXACT [] synonym: "ubiquitin-dependent proteolysis" EXACT [] is_a: GO:0019941 ! modification-dependent protein catabolic process [Term] id: GO:0006512 name: ubiquitin cycle namespace: biological_process def: "OBSOLETE. The cyclical process by which one or more ubiquitin moieties are added to (ubiquitination) and removed from (deubiquitination) a protein." [PMID:11917093] comment: This term was made obsolete because it implies that every protein that is ubiquitinated is also subsequently deubiquinitated, which is not true. Also, the process ontology does not include analogous terms for other small modifiers. is_obsolete: true [Term] id: GO:0006513 name: protein monoubiquitination namespace: biological_process def: "Addition of a single ubiquitin moiety to a protein." [GOC:ai] synonym: "protein monoubiquitinylation" EXACT [] synonym: "protein monoubiquitylation" EXACT [] is_a: GO:0016567 ! protein ubiquitination [Term] id: GO:0006515 name: misfolded or incompletely synthesized protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of misfolded or attenuated proteins." [GOC:jl] subset: gosubset_prok synonym: "degradation of misfolded or incompletely synthesized proteins" EXACT [] synonym: "misfolded or incompletely synthesized protein breakdown" EXACT [] synonym: "misfolded or incompletely synthesized protein catabolism" EXACT [] synonym: "misfolded or incompletely synthesized protein degradation" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0006516 name: glycoprotein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein breakdown" EXACT [] synonym: "glycoprotein catabolism" EXACT [] synonym: "glycoprotein degradation" EXACT [] is_a: GO:0009057 ! macromolecule catabolic process is_a: GO:0009100 ! glycoprotein metabolic process [Term] id: GO:0006517 name: protein deglycosylation namespace: biological_process def: "The removal of sugar residues from a glycosylated protein." [GOC:mah] subset: gosubset_prok synonym: "glycoprotein deglycosylation" EXACT [] is_a: GO:0006464 ! protein modification process is_a: GO:0006516 ! glycoprotein catabolic process [Term] id: GO:0006518 name: peptide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] subset: goslim_pir subset: gosubset_prok synonym: "peptide metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006519 name: cellular amino acid and derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents, and compounds derived from amino acids, as carried out by individual cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "amino acid and derivative metabolism" EXACT [GOC:curators] xref: Reactome:562581 "Metabolism of amino acids and derivatives" xref: Reactome:588207 "Metabolism of amino acids and derivatives" xref: Reactome:608968 "Metabolism of amino acids and derivatives" xref: Reactome:633650 "Metabolism of amino acids and derivatives" xref: Reactome:645278 "Metabolism of amino acids and derivatives" xref: Reactome:655655 "Metabolism of amino acids and derivatives" xref: Reactome:660930 "Metabolism of amino acids and derivatives" xref: Reactome:666705 "Metabolism of amino acids and derivatives" xref: Reactome:672801 "Metabolism of amino acids and derivatives" xref: Reactome:678525 "Metabolism of amino acids and derivatives" xref: Reactome:683481 "Metabolism of amino acids and derivatives" xref: Reactome:689685 "Metabolism of amino acids and derivatives" xref: Reactome:701421 "Metabolism of amino acids and derivatives" xref: Reactome:71291 "Metabolism of amino acids and derivatives" xref: Reactome:715992 "Metabolism of amino acids and derivatives" xref: Reactome:720719 "Metabolism of amino acids and derivatives" xref: Reactome:727939 "Metabolism of amino acids and derivatives" xref: Reactome:730911 "Metabolism of amino acids and derivatives" xref: Reactome:732997 "Metabolism of amino acids and derivatives" xref: Reactome:733843 "Metabolism of amino acids and derivatives" xref: Reactome:735551 "Metabolism of amino acids and derivatives" xref: Reactome:736532 "Metabolism of amino acids and derivatives" xref: Reactome:738461 "Metabolism of amino acids and derivatives" is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044238 ! primary metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006520 name: cellular amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pombe subset: gosubset_prok synonym: "amino acid metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid metabolism" EXACT [] is_a: GO:0006519 ! cellular amino acid and derivative metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process is_a: GO:0044106 ! cellular amine metabolic process [Term] id: GO:0006521 name: regulation of cellular amino acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving amino acids." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of amino acid metabolism" EXACT [] xref: Reactome:350562 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:562600 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:588226 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:609232 "Regulation of ornithine decarboxylase (ODC)" xref: Reactome:633672 "Regulation of ornithine decarboxylase (ODC)" is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0033238 ! regulation of cellular amine metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006520 ! cellular amino acid metabolic process relationship: regulates GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006522 name: alanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine metabolism" EXACT [] is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0006523 name: alanine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine anabolism" EXACT [] synonym: "alanine biosynthesis" EXACT [] synonym: "alanine formation" EXACT [] synonym: "alanine synthesis" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009079 ! pyruvate family amino acid biosynthetic process [Term] id: GO:0006524 name: alanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alanine, 2-aminopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "alanine breakdown" EXACT [] synonym: "alanine catabolism" EXACT [] synonym: "alanine degradation" EXACT [] is_a: GO:0006522 ! alanine metabolic process is_a: GO:0009080 ! pyruvate family amino acid catabolic process [Term] id: GO:0006525 name: arginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine metabolism" EXACT [] xref: Wikipedia:Arginine is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006526 name: arginine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "arginine anabolism" EXACT [] synonym: "arginine biosynthesis" EXACT [] synonym: "arginine formation" EXACT [] synonym: "arginine synthesis" EXACT [] xref: MetaCyc:ARGININE-SYN4-PWY xref: MetaCyc:ARGSYN-PWY xref: MetaCyc:ARGSYNBSUB-PWY is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006527 name: arginine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine, 2-amino-5-(carbamimidamido)pentanoic acid." [ChEBI:29016, GOC:go_curators] subset: gosubset_prok synonym: "arginine breakdown" EXACT [] synonym: "arginine catabolism" EXACT [] synonym: "arginine degradation" EXACT [] is_a: GO:0006525 ! arginine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006528 name: asparagine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine metabolism" EXACT [] xref: MetaCyc:ASPARAGINESYN-PWY is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006529 name: asparagine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine anabolism" EXACT [] synonym: "asparagine biosynthesis" EXACT [] synonym: "asparagine formation" EXACT [] synonym: "asparagine synthesis" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0006530 name: asparagine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of asparagine, 2-amino-3-carbamoylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "asparagine breakdown" EXACT [] synonym: "asparagine catabolism" EXACT [] synonym: "asparagine degradation" EXACT [] is_a: GO:0006528 ! asparagine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006531 name: aspartate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate metabolism" EXACT [] is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006532 name: aspartate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate anabolism" EXACT [] synonym: "aspartate biosynthesis" EXACT [] synonym: "aspartate formation" EXACT [] synonym: "aspartate synthesis" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0006533 name: aspartate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aspartate, the anion derived from aspartic acid, 2-aminobutanedioic acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aspartate breakdown" EXACT [] synonym: "aspartate catabolism" EXACT [] synonym: "aspartate degradation" EXACT [] is_a: GO:0006531 ! aspartate metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006534 name: cysteine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine metabolism" EXACT [] xref: Wikipedia:Cysteine_metabolism is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006535 name: cysteine biosynthetic process from serine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cysteine from other compounds, including serine." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine anabolism from serine" EXACT [] synonym: "cysteine formation from serine" EXACT [] synonym: "cysteine synthesis from serine" EXACT [] xref: MetaCyc:CYSTSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0019344 ! cysteine biosynthetic process [Term] id: GO:0006536 name: glutamate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate metabolism" EXACT [] synonym: "glutamic acid metabolic process" EXACT [] synonym: "glutamic acid metabolism" EXACT [] xref: Wikipedia:Glutamic_acid is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006537 name: glutamate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate anabolism" EXACT [] synonym: "glutamate biosynthesis" EXACT [] synonym: "glutamate biosynthesis, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthesis, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate dehydrogenase (NAD(P)+)" NARROW [] synonym: "glutamate biosynthetic process, using glutamate synthase (NADPH)" NARROW [] synonym: "glutamate formation" EXACT [] synonym: "glutamate synthesis" EXACT [] synonym: "glutamic acid biosynthesis" EXACT [] synonym: "glutamic acid biosynthetic process" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006538 name: glutamate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, the anion of 2-aminopentanedioic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown" EXACT [] synonym: "glutamate catabolism" EXACT [] synonym: "glutamate degradation" EXACT [] synonym: "glutamic acid catabolic process" EXACT [] synonym: "glutamic acid catabolism" EXACT [] is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006539 name: glutamate catabolic process via 2-oxoglutarate namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamate, via the intermediate 2-oxoglutarate." [GOC:go_curators] subset: gosubset_prok synonym: "glutamate breakdown via 2-oxoglutarate" EXACT [] synonym: "glutamate catabolic process via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolic process via alpha-oxoglutarate" EXACT [] synonym: "glutamate catabolism via 2-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-ketoglutarate" EXACT [] synonym: "glutamate catabolism via alpha-oxoglutarate" EXACT [] synonym: "glutamate degradation via 2-oxoglutarate" EXACT [] is_a: GO:0006103 ! 2-oxoglutarate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006540 name: glutamate decarboxylation to succinate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes." [PMID:12740438] subset: gosubset_prok synonym: "4-aminobutyrate shunt" EXACT [] synonym: "GABA shunt" EXACT [] synonym: "gamma-aminobutyrate shunt" EXACT [] xref: MetaCyc:GLUDEG-I-PWY xref: MetaCyc:PWY-4321 is_a: GO:0006105 ! succinate metabolic process is_a: GO:0006538 ! glutamate catabolic process [Term] id: GO:0006541 name: glutamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0006542 name: glutamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine anabolism" EXACT [] synonym: "glutamine biosynthesis" EXACT [] synonym: "glutamine formation" EXACT [] synonym: "glutamine synthesis" EXACT [] xref: MetaCyc:GLNSYN-PWY is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process [Term] id: GO:0006543 name: glutamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutamine, 2-amino-4-carbamoylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "glutamine breakdown" EXACT [] synonym: "glutamine catabolism" EXACT [] synonym: "glutamine degradation" EXACT [] is_a: GO:0006541 ! glutamine metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process [Term] id: GO:0006544 name: glycine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006545 name: glycine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine anabolism" EXACT [] synonym: "glycine biosynthesis" EXACT [] synonym: "glycine formation" EXACT [] synonym: "glycine synthesis" EXACT [] xref: MetaCyc:GLYCINE-SYN2-PWY is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006546 name: glycine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycine, aminoethanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "glycine breakdown" EXACT [] synonym: "glycine catabolism" EXACT [] synonym: "glycine degradation" EXACT [] is_a: GO:0006544 ! glycine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006547 name: histidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine metabolism" EXACT [] xref: Wikipedia:Histidine is_a: GO:0009075 ! histidine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006548 name: histidine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of histidine, 2-amino-3-(1H-imidazol-4-yl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "histidine breakdown" EXACT [] synonym: "histidine catabolism" EXACT [] synonym: "histidine degradation" EXACT [] xref: Reactome:562620 "Histidine catabolism" xref: Reactome:588246 "Histidine catabolism" xref: Reactome:609004 "Histidine catabolism" xref: Reactome:633693 "Histidine catabolism" xref: Reactome:655680 "Histidine catabolism" xref: Reactome:673162 "Histidine catabolism" xref: Reactome:701786 "Histidine catabolism" xref: Reactome:70921 "Histidine catabolism" xref: Reactome:716361 "Histidine catabolism" xref: Reactome:720844 "Histidine catabolism" xref: Reactome:727970 "Histidine catabolism" is_a: GO:0006547 ! histidine metabolic process is_a: GO:0009077 ! histidine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006549 name: isoleucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006550 name: isoleucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine breakdown" EXACT [] synonym: "isoleucine catabolism" EXACT [] synonym: "isoleucine degradation" EXACT [] xref: MetaCyc:ILEUDEG-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006551 name: leucine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006552 name: leucine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine breakdown" EXACT [] synonym: "leucine catabolism" EXACT [] synonym: "leucine degradation" EXACT [] xref: MetaCyc:LEU-DEG2-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006553 name: lysine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine metabolism" EXACT [] xref: Wikipedia:Lysine is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006554 name: lysine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine breakdown" EXACT [] synonym: "lysine catabolism" EXACT [] synonym: "lysine degradation" EXACT [] xref: Reactome:562595 "Lysine catabolism" xref: Reactome:588221 "Lysine catabolism" xref: Reactome:608982 "Lysine catabolism" xref: Reactome:633664 "Lysine catabolism" xref: Reactome:645284 "Lysine catabolism" xref: Reactome:655661 "Lysine catabolism" xref: Reactome:660943 "Lysine catabolism" xref: Reactome:666717 "Lysine catabolism" xref: Reactome:672815 "Lysine catabolism" xref: Reactome:678538 "Lysine catabolism" xref: Reactome:683581 "Lysine catabolism" xref: Reactome:689817 "Lysine catabolism" xref: Reactome:701532 "Lysine catabolism" xref: Reactome:71064 "Lysine catabolism" xref: Reactome:716116 "Lysine catabolism" xref: Reactome:727953 "Lysine catabolism" xref: Reactome:730982 "Lysine catabolism" xref: Reactome:733045 "Lysine catabolism" xref: Reactome:735608 "Lysine catabolism" xref: Reactome:738520 "Lysine catabolism" is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006555 name: methionine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "methionine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000096 ! sulfur amino acid metabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006556 name: S-adenosylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethionine, S-(5'-adenosyl)-L-methionine, an important intermediate in one-carbon metabolism." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "S-adenosyl methionine biosynthesis" EXACT [] synonym: "S-adenosyl methionine biosynthetic process" EXACT [] synonym: "S-adenosylmethionine anabolism" EXACT [] synonym: "S-adenosylmethionine biosynthesis" EXACT [] synonym: "S-adenosylmethionine formation" EXACT [] synonym: "S-adenosylmethionine synthesis" EXACT [] synonym: "SAM biosynthetic process" EXACT [] xref: MetaCyc:SAM-PWY is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046500 ! S-adenosylmethionine metabolic process relationship: part_of GO:0000097 ! sulfur amino acid biosynthetic process [Term] id: GO:0006557 name: S-adenosylmethioninamine biosynthetic process namespace: biological_process alt_id: GO:0006745 def: "The chemical reactions and pathways resulting in the formation of S-adenosylmethioninamine, (5-deoxy-5-adenosyl)(3-aminopropyl) methylsulfonium salt." [GOC:mah, MetaCyc:S-ADENOSYLMETHIONINAMINE] subset: gosubset_prok synonym: "S-adenosylmethioninamine anabolism" EXACT [] synonym: "S-adenosylmethioninamine biosynthesis" EXACT [] synonym: "S-adenosylmethioninamine formation" EXACT [] synonym: "S-adenosylmethioninamine synthesis" EXACT [] is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046499 ! S-adenosylmethioninamine metabolic process [Term] id: GO:0006558 name: L-phenylalanine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [ChEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-phenylalanine metabolism" EXACT [] synonym: "phenylalanine metabolic process" BROAD [] synonym: "phenylalanine metabolism" BROAD [] is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006559 name: L-phenylalanine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylalanine, 2-amino-3-phenylpropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "L-phenylalanine breakdown" EXACT [] synonym: "L-phenylalanine catabolism" EXACT [] synonym: "L-phenylalanine degradation" EXACT [] synonym: "phenylalanine catabolic process" BROAD [] synonym: "phenylalanine catabolism" BROAD [] xref: Reactome:562621 "Phenylalanine and tyrosine catabolism" xref: Reactome:588247 "Phenylalanine and tyrosine catabolism" xref: Reactome:609005 "Phenylalanine and tyrosine catabolism" xref: Reactome:633694 "Phenylalanine and tyrosine catabolism" xref: Reactome:645308 "Phenylalanine and tyrosine catabolism" xref: Reactome:655681 "Phenylalanine and tyrosine catabolism" xref: Reactome:666731 "Phenylalanine and tyrosine catabolism" xref: Reactome:673150 "Phenylalanine and tyrosine catabolism" xref: Reactome:678561 "Phenylalanine and tyrosine catabolism" xref: Reactome:683518 "Phenylalanine and tyrosine catabolism" xref: Reactome:689720 "Phenylalanine and tyrosine catabolism" xref: Reactome:701452 "Phenylalanine and tyrosine catabolism" xref: Reactome:71182 "Phenylalanine and tyrosine catabolism" xref: Reactome:716023 "Phenylalanine and tyrosine catabolism" xref: Reactome:727971 "Phenylalanine and tyrosine catabolism" xref: Reactome:733009 "Phenylalanine and tyrosine catabolism" xref: Reactome:735674 "Phenylalanine and tyrosine catabolism" xref: Reactome:736536 "Phenylalanine and tyrosine catabolism" xref: Reactome:738482 "Phenylalanine and tyrosine catabolism" is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0006560 name: proline metabolic process namespace: biological_process def: "The chemical reactions and pathways involving proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline metabolism" EXACT [] is_a: GO:0009064 ! glutamine family amino acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006561 name: proline biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline anabolism" EXACT [] synonym: "proline biosynthesis" EXACT [] synonym: "proline formation" EXACT [] synonym: "proline synthesis" EXACT [] xref: MetaCyc:PROSYN-PWY xref: MetaCyc:PWY-3341 is_a: GO:0006560 ! proline metabolic process is_a: GO:0009084 ! glutamine family amino acid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process [Term] id: GO:0006562 name: proline catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "proline breakdown" EXACT [] synonym: "proline catabolism" EXACT [] synonym: "proline degradation" EXACT [] xref: Reactome:563264 "Proline catabolism" xref: Reactome:588873 "Proline catabolism" xref: Reactome:609588 "Proline catabolism" xref: Reactome:634297 "Proline catabolism" xref: Reactome:645766 "Proline catabolism" xref: Reactome:656093 "Proline catabolism" xref: Reactome:661315 "Proline catabolism" xref: Reactome:667038 "Proline catabolism" xref: Reactome:673185 "Proline catabolism" xref: Reactome:678875 "Proline catabolism" xref: Reactome:683806 "Proline catabolism" xref: Reactome:690104 "Proline catabolism" xref: Reactome:701848 "Proline catabolism" xref: Reactome:70688 "Proline catabolism" xref: Reactome:716422 "Proline catabolism" xref: Reactome:728314 "Proline catabolism" xref: Reactome:735661 "Proline catabolism" xref: Reactome:738585 "Proline catabolism" is_a: GO:0006560 ! proline metabolic process is_a: GO:0009065 ! glutamine family amino acid catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006563 name: L-serine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0006564 name: L-serine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine anabolism" EXACT [] synonym: "L-serine biosynthesis" EXACT [] synonym: "L-serine formation" EXACT [] synonym: "L-serine synthesis" EXACT [] xref: MetaCyc:SERSYN-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009070 ! serine family amino acid biosynthetic process [Term] id: GO:0006565 name: L-serine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of L-serine, the L-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid." [ChEBI:17115, GOC:ai, GOC:jsg] subset: gosubset_prok synonym: "L-serine breakdown" EXACT [] synonym: "L-serine catabolism" EXACT [] synonym: "L-serine degradation" EXACT [] xref: MetaCyc:SERDEG-PWY is_a: GO:0006563 ! L-serine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0006566 name: threonine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine and threonine metabolic process" BROAD [] synonym: "methionine and threonine metabolism" BROAD [] synonym: "threonine metabolism" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0006567 name: threonine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "threonine breakdown" EXACT [] synonym: "threonine catabolism" EXACT [] synonym: "threonine degradation" EXACT [] xref: MetaCyc:THREOCAT-PWY xref: UM-BBD_pathwayID:met is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0006568 name: tryptophan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "tryptophan metabolism" EXACT [] xref: Wikipedia:Tryptophan is_a: GO:0006586 ! indolalkylamine metabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006569 name: tryptophan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid." [ISBN:0198547684] subset: gosubset_prok synonym: "tryptophan breakdown" EXACT [] synonym: "tryptophan catabolic process, using tryptophanase" NARROW [] synonym: "tryptophan catabolism" EXACT [] synonym: "tryptophan catabolism, using tryptophanase" NARROW [] synonym: "tryptophan degradation" EXACT [] xref: Reactome:562593 "Tryptophan catabolism" xref: Reactome:588219 "Tryptophan catabolism" xref: Reactome:608980 "Tryptophan catabolism" xref: Reactome:633662 "Tryptophan catabolism" xref: Reactome:645282 "Tryptophan catabolism" xref: Reactome:655659 "Tryptophan catabolism" xref: Reactome:660941 "Tryptophan catabolism" xref: Reactome:666725 "Tryptophan catabolism" xref: Reactome:672812 "Tryptophan catabolism" xref: Reactome:683511 "Tryptophan catabolism" xref: Reactome:690033 "Tryptophan catabolism" xref: Reactome:701818 "Tryptophan catabolism" xref: Reactome:71240 "Tryptophan catabolism" xref: Reactome:716393 "Tryptophan catabolism" xref: Reactome:727951 "Tryptophan catabolism" xref: Reactome:738605 "Tryptophan catabolism" is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process is_a: GO:0046218 ! indolalkylamine catabolic process [Term] id: GO:0006570 name: tyrosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine metabolism" EXACT [] xref: UM-BBD_pathwayID:tyr xref: Wikipedia:Tyrosine is_a: GO:0009072 ! aromatic amino acid family metabolic process [Term] id: GO:0006571 name: tyrosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:sm] subset: gosubset_prok synonym: "tyrosine anabolism" EXACT [] synonym: "tyrosine biosynthesis" EXACT [] synonym: "tyrosine formation" EXACT [] synonym: "tyrosine synthesis" EXACT [] xref: MetaCyc:PWY-3461 is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway [Term] id: GO:0006572 name: tyrosine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tyrosine, an aromatic amino acid, 2-amino-3-(4-hydroxyphenyl)propanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "tyrosine breakdown" EXACT [] synonym: "tyrosine catabolism" EXACT [] synonym: "tyrosine degradation" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0009074 ! aromatic amino acid family catabolic process [Term] id: GO:0006573 name: valine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine metabolism" EXACT [] is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0006574 name: valine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine breakdown" EXACT [] synonym: "valine catabolism" EXACT [] synonym: "valine degradation" EXACT [] xref: MetaCyc:VALDEG-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009083 ! branched chain family amino acid catabolic process [Term] id: GO:0006575 name: cellular amino acid derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: gosubset_prok synonym: "amino acid derivative metabolic process" EXACT [GOC:curators] synonym: "cellular amino acid derivative metabolism" EXACT [] synonym: "cellular modified amino acid metabolic process" EXACT [ChEBI:25359, GOC:mah] is_a: GO:0006519 ! cellular amino acid and derivative metabolic process [Term] id: GO:0006576 name: cellular biogenic amine metabolic process namespace: biological_process def: "The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters." [GOC:jl, ISBN:0395825172] subset: gosubset_prok synonym: "biogenic amine metabolism" EXACT [] is_a: GO:0006575 ! cellular amino acid derivative metabolic process is_a: GO:0044106 ! cellular amine metabolic process [Term] id: GO:0006577 name: betaine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006578 name: betaine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine anabolism" EXACT [] synonym: "betaine biosynthesis" EXACT [] synonym: "betaine formation" EXACT [] synonym: "betaine synthesis" EXACT [] is_a: GO:0006577 ! betaine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0006579 name: betaine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any betaine, the N-trimethyl derivative of an amino acid." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "betaine breakdown" EXACT [] synonym: "betaine catabolism" EXACT [] synonym: "betaine degradation" EXACT [] is_a: GO:0006577 ! betaine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006580 name: ethanolamine metabolic process namespace: biological_process alt_id: GO:0006645 def: "The chemical reactions and pathways involving ethanolamine (2-aminoethanol), an important water-soluble base of phospholipid (phosphatidylethanolamine)." [ChEBI:16000, GOC:jl, ISBN:01928006X] subset: gosubset_prok synonym: "ethanolamine metabolism" EXACT [] is_a: GO:0042439 ! ethanolamine and derivative metabolic process [Term] id: GO:0006581 name: acetylcholine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine breakdown" EXACT [] synonym: "acetylcholine catabolism" EXACT [] synonym: "acetylcholine degradation" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042135 ! neurotransmitter catabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006582 name: melanin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving melanins, pigments largely of animal origin. High molecular weight polymers of indole quinone, they are irregular polymeric structures and are divided into three groups: allomelanins in the plant kingdom and eumelanins and phaeomelanins in the animal kingdom." [GOC:go_curators] subset: gosubset_prok synonym: "melanin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0042440 ! pigment metabolic process [Term] id: GO:0006583 name: melanin biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of melanin from other compounds, including tyrosine." [GOC:go_curators] subset: gosubset_prok synonym: "melanin anabolism from tyrosine" EXACT [] synonym: "melanin formation from tyrosine" EXACT [] synonym: "melanin synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042438 ! melanin biosynthetic process [Term] id: GO:0006584 name: catecholamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a group of physiologically important biogenic amines that possess a catechol (3,4-dihydroxyphenyl) nucleus and are derivatives of 3,4-dihydroxyphenylethylamine." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "catecholamine metabolism" EXACT [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0009712 ! catechol metabolic process [Term] id: GO:0006585 name: dopamine biosynthetic process from tyrosine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dopamine (3,4-dihydroxyphenylethylamine) from L-tyrosine, via the metabolic precursor 3,4-dihydroxy-L-phenylalanine (L-dopa). Dopamine is a catecholamine neurotransmitter and a metabolic precursor of norepinephrine and epinephrine." [GOC:bf, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "dopamine anabolism from tyrosine" EXACT [] synonym: "dopamine formation from tyrosine" EXACT [] synonym: "dopamine synthesis from tyrosine" EXACT [] is_a: GO:0006570 ! tyrosine metabolic process is_a: GO:0042416 ! dopamine biosynthetic process [Term] id: GO:0006586 name: indolalkylamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indolalkylamines, indole or indole derivatives containing a primary, secondary, or tertiary amine group." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "indolalkylamine metabolism" EXACT [] synonym: "indolamine metabolic process" BROAD [] synonym: "indolamine metabolism" BROAD [] is_a: GO:0006576 ! cellular biogenic amine metabolic process is_a: GO:0042434 ! indole derivative metabolic process [Term] id: GO:0006587 name: serotonin biosynthetic process from tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation from tryptophan of serotonin (5-hydroxytryptamine), a monoamine neurotransmitter occurring in the peripheral and central nervous systems, also having hormonal properties." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "serotonin anabolism from tryptophan" EXACT [] synonym: "serotonin formation from tryptophan" EXACT [] synonym: "serotonin synthesis from tryptophan" EXACT [] is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0042427 ! serotonin biosynthetic process [Term] id: GO:0006588 name: activation of tryptophan 5-monooxygenase activity namespace: biological_process def: "The process by which the tryptophan 5-monooxygenase enzyme is changed so that it can carry out its enzymatic activity." [GOC:dph, GOC:tb] synonym: "tryptophan hydroxylase activation" RELATED [GOC:dph, GOC:tb] is_a: GO:0032770 ! positive regulation of monooxygenase activity relationship: part_of GO:0006587 ! serotonin biosynthetic process from tryptophan [Term] id: GO:0006589 name: octopamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of octopamine, 1-(p-hydroxyphenyl)-2-aminoethanol. The D enantiomer is about one-tenth as active as norepihephrine and is found in the salivary glands of Octopus and Eledone species." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "octopamine anabolism" EXACT [] synonym: "octopamine biosynthesis" EXACT [] synonym: "octopamine formation" EXACT [] synonym: "octopamine synthesis" EXACT [] is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process is_a: GO:0046189 ! phenol biosynthetic process is_a: GO:0046333 ! octopamine metabolic process [Term] id: GO:0006590 name: thyroid hormone generation namespace: biological_process def: "The formation of either of the compounds secreted by the thyroid gland, mainly thyroxine and triiodothyronine. This is achieved by the iodination and joining of tyrosine molecules to form the precursor thyroglobin, proteolysis of this precursor gives rise to the thyroid hormones." [GOC:jl, ISBN:0716720094] comment: Note that this term does not fall under the general GO definition for biosynthetic processes, which is 'The chemical reactions and pathways resulting in the formation of... ', because thyroid hormones can only be formed by the proteolysis of a larger molecule (see term definition). The word 'generation' is therefore used in place of biosynthesis. is_a: GO:0042403 ! thyroid hormone metabolic process [Term] id: GO:0006591 name: ornithine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0006592 name: ornithine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine anabolism" EXACT [] synonym: "ornithine biosynthesis" EXACT [] synonym: "ornithine formation" EXACT [] synonym: "ornithine synthesis" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0008652 ! cellular amino acid biosynthetic process [Term] id: GO:0006593 name: ornithine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "ornithine breakdown" EXACT [] synonym: "ornithine catabolism" EXACT [] synonym: "ornithine degradation" EXACT [] is_a: GO:0006591 ! ornithine metabolic process is_a: GO:0009063 ! cellular amino acid catabolic process [Term] id: GO:0006595 name: polyamine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine metabolism" EXACT [] xref: Reactome:351202 "Metabolism of polyamines" xref: Reactome:562842 "Metabolism of polyamines" xref: Reactome:588462 "Metabolism of polyamines" xref: Reactome:609203 "Metabolism of polyamines" xref: Reactome:633896 "Metabolism of polyamines" xref: Reactome:645652 "Metabolism of polyamines" xref: Reactome:656138 "Metabolism of polyamines" xref: Reactome:661029 "Metabolism of polyamines" xref: Reactome:667065 "Metabolism of polyamines" xref: Reactome:672917 "Metabolism of polyamines" xref: Reactome:678630 "Metabolism of polyamines" xref: Reactome:683836 "Metabolism of polyamines" xref: Reactome:690074 "Metabolism of polyamines" xref: Reactome:701514 "Metabolism of polyamines" xref: Reactome:716100 "Metabolism of polyamines" xref: Reactome:720893 "Metabolism of polyamines" xref: Reactome:728349 "Metabolism of polyamines" xref: Reactome:731156 "Metabolism of polyamines" xref: Reactome:733038 "Metabolism of polyamines" xref: Reactome:733882 "Metabolism of polyamines" xref: Reactome:735601 "Metabolism of polyamines" xref: Reactome:736553 "Metabolism of polyamines" xref: Reactome:738615 "Metabolism of polyamines" is_a: GO:0006576 ! cellular biogenic amine metabolic process [Term] id: GO:0006596 name: polyamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine anabolism" EXACT [] synonym: "polyamine biosynthesis" EXACT [] synonym: "polyamine formation" EXACT [] synonym: "polyamine synthesis" EXACT [] xref: MetaCyc:POLYAMSYN-PWY xref: Reactome:351200 "Interconversion of polyamines" xref: Reactome:563291 "Interconversion of polyamines" xref: Reactome:588908 "Interconversion of polyamines" xref: Reactome:609624 "Interconversion of polyamines" xref: Reactome:634419 "Interconversion of polyamines" xref: Reactome:645880 "Interconversion of polyamines" xref: Reactome:656198 "Interconversion of polyamines" xref: Reactome:661337 "Interconversion of polyamines" xref: Reactome:667121 "Interconversion of polyamines" xref: Reactome:673262 "Interconversion of polyamines" xref: Reactome:678948 "Interconversion of polyamines" xref: Reactome:701868 "Interconversion of polyamines" xref: Reactome:716442 "Interconversion of polyamines" xref: Reactome:728402 "Interconversion of polyamines" xref: Reactome:738622 "Interconversion of polyamines" is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0006597 name: spermine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "spermine anabolism" EXACT [] synonym: "spermine biosynthesis" EXACT [] synonym: "spermine formation" EXACT [] synonym: "spermine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008215 ! spermine metabolic process [Term] id: GO:0006598 name: polyamine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyamine breakdown" EXACT [] synonym: "polyamine catabolism" EXACT [] synonym: "polyamine degradation" EXACT [] is_a: GO:0006595 ! polyamine metabolic process is_a: GO:0042402 ! cellular biogenic amine catabolic process [Term] id: GO:0006599 name: phosphagen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphagen, any of a group of guanidine phosphates that occur in muscle and can be used to regenerate ATP from ADP during muscular contraction." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphagen metabolism" EXACT [] is_a: GO:0006575 ! cellular amino acid derivative metabolic process [Term] id: GO:0006600 name: creatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving creatine (N-(aminoiminomethyl)-N-methylglycine), a compound synthesized from the amino acids arginine, glycine, and methionine that occurs in muscle." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "creatine metabolism" EXACT [] xref: Reactome:562883 "Creatine metabolism" xref: Reactome:588504 "Creatine metabolism" xref: Reactome:609239 "Creatine metabolism" xref: Reactome:633938 "Creatine metabolism" xref: Reactome:645632 "Creatine metabolism" xref: Reactome:655960 "Creatine metabolism" xref: Reactome:672948 "Creatine metabolism" xref: Reactome:689899 "Creatine metabolism" xref: Reactome:71288 "Creatine metabolism" is_a: GO:0006599 ! phosphagen metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0019752 ! carboxylic acid metabolic process [Term] id: GO:0006601 name: creatine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of creatine, N-[amino(imino)methyl]-N-methylglycine. Creatine is formed by a process beginning with amidino group transfer from L-arginine to glycine to form guanidinoacetate, followed by methyl group transfer from S-adenosyl-L-methionine to guanidinoacetate; it is then is phosphorylated to form a pool that stores high energy phosphate for the replenishment of ATP during periods of high, or fluctuating energy demand. In animals, most creatine is transported to and used in muscle." [ChEBI:16919, GOC:mah, MetaCyc:GLYCGREAT-PWY, MetaCyc:PWY-6158] subset: gosubset_prok synonym: "creatine anabolism" EXACT [] synonym: "creatine biosynthesis" EXACT [] synonym: "creatine formation" EXACT [] synonym: "creatine synthesis" EXACT [] is_a: GO:0006600 ! creatine metabolic process is_a: GO:0042396 ! phosphagen biosynthetic process [Term] id: GO:0006602 name: creatinine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of creatinine, 2-amino-1,5-dihydro-1-methyl-4H-imidazol-4-one, an end product of creatine metabolism and a normal constituent of urine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "creatinine breakdown" EXACT [] synonym: "creatinine catabolism" EXACT [] synonym: "creatinine degradation" EXACT [] is_a: GO:0042397 ! phosphagen catabolic process is_a: GO:0043605 ! cellular amide catabolic process is_a: GO:0046449 ! creatinine metabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0006603 name: phosphocreatine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphocreatine, a phosphagen of creatine present in high concentration in striated muscle which is synthesized and broken down by creatine phosphokinase to buffer ATP concentration. It acts as an immediate energy reserve for muscle." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "phosphocreatine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006604 name: phosphoarginine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphoarginine, a phosphagen of L-arginine with phosphoric acid containing the phosphoamide bond. It is a source of energy in the contraction of muscle in invertebrates, corresponding to phosphocreatine in the muscles of vertebrates." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "phosphoarginine metabolism" EXACT [] is_a: GO:0006599 ! phosphagen metabolic process [Term] id: GO:0006605 name: protein targeting namespace: biological_process def: "The process of targeting specific proteins to particular membrane-bounded subcellular organelles. Usually requires an organelle specific protein sequence motif." [GOC:ma] subset: goslim_pombe subset: gosubset_prok synonym: "nascent polypeptide association" RELATED [] synonym: "protein sorting along secretory pathway" NARROW [] xref: Wikipedia:Protein_targeting is_a: GO:0006886 ! intracellular protein transport [Term] id: GO:0006606 name: protein import into nucleus namespace: biological_process def: "The directed movement of a protein from the cytoplasm to the nucleus." [GOC:jl] synonym: "protein import into cell nucleus" EXACT [] synonym: "protein nucleus import" EXACT [] synonym: "protein targeting to nucleus" EXACT [GOC:mah] synonym: "protein transport from cytoplasm to nucleus" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0017038 ! protein import is_a: GO:0051170 ! nuclear import relationship: part_of GO:0034504 ! protein localization in nucleus [Term] id: GO:0006607 name: NLS-bearing substrate import into nucleus namespace: biological_process def: "The directed movement of a protein bearing a nuclear localization signal (NLS) from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "NLS-bearing substrate import into cell nucleus" EXACT [] synonym: "NLS-bearing substrate transport from cytoplasm to nucleus" EXACT [] synonym: "NLS-bearing substrate-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006608 name: snRNP protein import into nucleus namespace: biological_process def: "The directed movement of a small nuclear ribonucleoprotein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "snRNP protein import into cell nucleus" EXACT [] synonym: "snRNP protein transport from cytoplasm to nucleus" EXACT [] synonym: "snRNP protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006609 name: mRNA-binding (hnRNP) protein import into nucleus namespace: biological_process def: "The directed movement of a heterogeneous nuclear ribonucleoprotein complex from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:mah] synonym: "mRNA-binding (hnRNP) protein import into cell nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein transport from cytoplasm to nucleus" EXACT [] synonym: "mRNA-binding (hnRNP) protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006610 name: ribosomal protein import into nucleus namespace: biological_process def: "The directed movement of a ribosomal protein from the cytoplasm into the nucleus, across the nuclear membrane." [GOC:ai] synonym: "ribosomal protein import into cell nucleus" EXACT [] synonym: "ribosomal protein transport from cytoplasm to nucleus" EXACT [] synonym: "ribosomal protein-nucleus import" EXACT [] is_a: GO:0006606 ! protein import into nucleus [Term] id: GO:0006611 name: protein export from nucleus namespace: biological_process def: "The directed movement of a protein from the nucleus into the cytoplasm." [GOC:jl] synonym: "protein export from cell nucleus" EXACT [] synonym: "protein export out of nucleus" EXACT [] synonym: "protein transport from nucleus to cytoplasm" EXACT [] synonym: "protein-nucleus export" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0051168 ! nuclear export [Term] id: GO:0006612 name: protein targeting to membrane namespace: biological_process def: "The process of directing proteins towards a membrane, usually using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] synonym: "protein membrane targeting" EXACT [] synonym: "protein-membrane targeting" EXACT [] is_a: GO:0006605 ! protein targeting [Term] id: GO:0006613 name: cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation. The transport of most secretory proteins, particularly those with more than 100 amino acids, into the endoplasmic reticulum lumen occurs in this manner, as does the import of some proteins into mitochondria." [ISBN:0716731363, PMID:10512867, PMID:16896215] synonym: "cotranslational membrane targeting" EXACT [] synonym: "cotranslational protein membrane targeting" EXACT [] synonym: "cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane [Term] id: GO:0006614 name: SRP-dependent cotranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting" EXACT [] is_a: GO:0006613 ! cotranslational protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006615 name: SRP-dependent cotranslational protein targeting to membrane, docking namespace: biological_process def: "The process by which an SRP-bound ribosome forms a complex with the SRP receptor in the ER membrane, allowing the ribosome to bind to the membrane, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "protein docking during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, docking" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, docking" EXACT [] is_a: GO:0022615 ! protein to membrane docking relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006616 name: SRP-dependent cotranslational protein targeting to membrane, translocation namespace: biological_process def: "The process during cotranslational membrane targeting wherein proteins move across a membrane. SRP and its receptor initiate the transfer of the nascent chain across the endoplasmic reticulum (ER) membrane; they then dissociate from the chain, which is transferred to a set of transmembrane proteins, collectively called the translocon. Once the nascent chain translocon complex is assembled, the elongating chain passes directly from the large ribosomal subunit into the centers of the translocon, a protein-lined channel within the membrane. The growing chain is never exposed to the cytosol and does not fold until it reaches the ER lumen." [ISBN:0716731363] synonym: "ER translocation" BROAD [] synonym: "SRP-dependent cotranslational membrane targeting, translocation" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, translocation" EXACT [] synonym: "translocation during SRP-dependent cotranslational protein targeting to membrane" EXACT [] is_a: GO:0065002 ! intracellular protein transmembrane transport relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006617 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition namespace: biological_process def: "The process by which SRP binds to the signal peptide in a nascent protein, causing protein elongation to pause, during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence recognition during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence recognition" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence recognition" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006618 name: SRP-dependent cotranslational protein targeting to membrane, signal sequence processing namespace: biological_process def: "The removal of the signal peptide from a nascent protein during cotranslational membrane targeting." [ISBN:0815316194] synonym: "signal sequence processing during SRP-dependent cotranslational protein targeting to membrane" EXACT [] synonym: "SRP-dependent cotranslational membrane targeting, signal sequence processing" EXACT [] synonym: "SRP-dependent cotranslational protein-membrane targeting, signal sequence processing" EXACT [] is_a: GO:0006465 ! signal peptide processing relationship: part_of GO:0006614 ! SRP-dependent cotranslational protein targeting to membrane [Term] id: GO:0006619 name: SRP-independent cotranslational protein-membrane targeting namespace: biological_process def: "OBSOLETE. The targeting of proteins to a membrane that occurs during translation and is independent of SRP and signal recognition." [GOC:ai, PMID:11101515] comment: This term was made obsolete because there is no evidence for the existence of this process. synonym: "ER translocation" BROAD [] synonym: "SRP-independent cotranslational membrane targeting" EXACT [] is_obsolete: true [Term] id: GO:0006620 name: posttranslational protein targeting to membrane namespace: biological_process def: "The targeting of proteins to a membrane that occurs after their translation. Some secretory proteins exhibit posttranslational transport into the endoplasmic reticulum (ER) lumen: they are synthesized in their entirety on free cytosolic ribosomes and then released into the cytosol, where they are bound by chaperones which keep them in an unfolded state, and subsequently are translocated across the ER membrane." [ISBN:0716731363] synonym: "posttranslational membrane targeting" EXACT [] synonym: "posttranslational protein membrane targeting" EXACT [] synonym: "posttranslational protein-membrane targeting" EXACT [] synonym: "SRP-independent protein-membrane targeting" EXACT [] is_a: GO:0006612 ! protein targeting to membrane is_a: GO:0045047 ! protein targeting to ER [Term] id: GO:0006621 name: protein retention in ER lumen namespace: biological_process def: "The retention in the endoplasmic reticulum (ER) lumen of soluble resident proteins. Sorting receptors retrieve proteins with ER localization signals, such as KDEL and HDEL sequences or some transmembrane domains, that have escaped to the cis-Golgi network and return them to the ER. Abnormally folded proteins and unassembled subunits are also selectively retained in the ER." [ISBN:0716731363, PMID:12972550] synonym: "maintenance of protein location in ER lumen" BROAD [GOC:dph, GOC:tb] is_a: GO:0035437 ! maintenance of protein localization in endoplasmic reticulum [Term] id: GO:0006622 name: protein targeting to lysosome namespace: biological_process def: "The process of directing proteins towards the lysosome using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] synonym: "protein-lysosome targeting" EXACT [] is_a: GO:0006623 ! protein targeting to vacuole is_a: GO:0007041 ! lysosomal transport [Term] id: GO:0006623 name: protein targeting to vacuole namespace: biological_process def: "The process of directing proteins towards the vacuole, usually using signals contained within the protein." [http://cancerweb.ncl.ac.uk/] synonym: "protein vacuolar targeting" EXACT [] synonym: "protein-vacuolar targeting" EXACT [] synonym: "protein-vacuole targeting" EXACT [] synonym: "vacuolar protein sorting" EXACT [GOC:vw] is_a: GO:0006605 ! protein targeting is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0006624 name: vacuolar protein processing namespace: biological_process def: "The posttranslational modification of proteins in the vacuole, including proteolytic cleavage of precursors to form active enzymes." [GOC:mah] synonym: "vacuolar protein maturation" EXACT [] synonym: "vacuolar proteolysis" EXACT [] is_a: GO:0016485 ! protein processing [Term] id: GO:0006625 name: protein targeting to peroxisome namespace: biological_process def: "The process of directing proteins towards the peroxisome, usually using signals contained within the protein." [GOC:ai] synonym: "protein-peroxisome targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0043574 ! peroxisomal transport relationship: part_of GO:0007031 ! peroxisome organization [Term] id: GO:0006626 name: protein targeting to mitochondrion namespace: biological_process alt_id: GO:0043681 def: "The process of directing proteins towards and into the mitochondrion, usually mediated by mitochondrial proteins that recognize signals contained within the imported protein." [GOC:mcc, ISBN:0716731363] synonym: "mitochondrial protein import" RELATED [] synonym: "mitochondrial translocation" RELATED [] synonym: "protein import into mitochondrion" EXACT [] synonym: "protein targeting to mitochondria" EXACT [] synonym: "protein-mitochondrial targeting" EXACT [] is_a: GO:0006605 ! protein targeting is_a: GO:0006839 ! mitochondrial transport is_a: GO:0017038 ! protein import relationship: part_of GO:0007005 ! mitochondrion organization relationship: part_of GO:0070585 ! protein localization in mitochondrion [Term] id: GO:0006627 name: protein processing involved in protein targeting to mitochondrion namespace: biological_process def: "The cleavage of peptide bonds in proteins, usually near the N terminus, contributing to the process of import into the mitochondrion. Several different peptidases mediate cleavage of proteins destined for different mitochondrial compartments." [GOC:mcc, PMID:12191769] synonym: "mitochondrial processing" BROAD [] synonym: "mitochondrial protein processing during import" RELATED [GOC:dph, GOC:tb] is_a: GO:0034982 ! mitochondrial protein processing relationship: part_of GO:0006626 ! protein targeting to mitochondrion [Term] id: GO:0006628 name: mitochondrial translocation namespace: biological_process def: "OBSOLETE. The translocation of proteins across the mitochondrial membrane. In the presence of a translocating chain, the outer membrane import machinery (MOM complex) and the inner membrane import machinery (MIM complex) form translocation contact sites as a part of the membrane preprotein import machinery." [PMID:7600576] comment: This term was made obsolete because its definition was equivalent to that of the biological process term 'mitochondrial matrix protein import ; GO:0030150' while the mitochondrial translocation has a broader meaning; this led to mis-annotation. is_obsolete: true consider: GO:0006626 [Term] id: GO:0006629 name: lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids." [GOC:ma] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: gosubset_prok synonym: "lipid metabolism" EXACT [] xref: Reactome:562524 "Metabolism of lipids and lipoproteins" xref: Reactome:588150 "Metabolism of lipids and lipoproteins" xref: Reactome:608918 "Metabolism of lipids and lipoproteins" xref: Reactome:633600 "Metabolism of lipids and lipoproteins" xref: Reactome:645232 "Metabolism of lipids and lipoproteins" xref: Reactome:655606 "Metabolism of lipids and lipoproteins" xref: Reactome:660894 "Metabolism of lipids and lipoproteins" xref: Reactome:666677 "Metabolism of lipids and lipoproteins" xref: Reactome:672769 "Metabolism of lipids and lipoproteins" xref: Reactome:678523 "Metabolism of lipids and lipoproteins" xref: Reactome:683448 "Metabolism of lipids and lipoproteins" xref: Reactome:689644 "Metabolism of lipids and lipoproteins" xref: Reactome:701383 "Metabolism of lipids and lipoproteins" xref: Reactome:715954 "Metabolism of lipids and lipoproteins" xref: Reactome:720657 "Metabolism of lipids and lipoproteins" xref: Reactome:727904 "Metabolism of lipids and lipoproteins" xref: Reactome:730909 "Metabolism of lipids and lipoproteins" xref: Reactome:732978 "Metabolism of lipids and lipoproteins" xref: Reactome:733846 "Metabolism of lipids and lipoproteins" xref: Reactome:735523 "Metabolism of lipids and lipoproteins" xref: Reactome:736535 "Metabolism of lipids and lipoproteins" xref: Reactome:738426 "Metabolism of lipids and lipoproteins" xref: Reactome:73923 "Metabolism of lipids and lipoproteins" xref: Wikipedia:Lipid_metabolism is_a: GO:0044238 ! primary metabolic process [Term] id: GO:0006630 name: lipid binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0008289 [Term] id: GO:0006631 name: fatty acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis." [ISBN:0198547684] subset: gosubset_prok synonym: "fatty acid metabolism" EXACT [] xref: Reactome:546991 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:574005 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:597725 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:620859 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:639319 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:650056 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:658357 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:663914 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:669810 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:680944 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:686570 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:696038 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:709237 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:724206 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:737369 "CYP4A11 omega-hydroxylates laurate" xref: Reactome:76466 "CYP4A11 omega-hydroxylates laurate" xref: Wikipedia:Fatty_acid_metabolism is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006633 name: fatty acid biosynthetic process namespace: biological_process alt_id: GO:0000037 def: "The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fatty acid anabolism" EXACT [] synonym: "fatty acid biosynthesis" EXACT [] synonym: "fatty acid formation" EXACT [] synonym: "fatty acid synthesis" EXACT [] xref: MetaCyc:FASYN-INITIAL-PWY xref: MetaCyc:PWY-4381 xref: MetaCyc:PWY-5156 xref: Wikipedia:Fatty_acid_synthesis is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0006634 name: hexadecanal biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hexadecanal, the C16 straight chain aldehyde." [http://chemfinder.cambridgesoft.com/] subset: gosubset_prok synonym: "hexadecanal anabolism" EXACT [] synonym: "hexadecanal biosynthesis" EXACT [] synonym: "hexadecanal formation" EXACT [] synonym: "hexadecanal synthesis" EXACT [] synonym: "palmitaldehyde biosynthesis" EXACT [] synonym: "palmitaldehyde biosynthetic process" EXACT [] is_a: GO:0046184 ! aldehyde biosynthetic process is_a: GO:0046458 ! hexadecanal metabolic process [Term] id: GO:0006635 name: fatty acid beta-oxidation namespace: biological_process def: "A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:FAO-PWY] subset: gosubset_prok xref: Reactome:109339 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:109341 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:109342 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:109343 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:109998 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:547632 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:553903 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:559783 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:560108 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:560123 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:562544 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:563102 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:574696 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:579807 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:585539 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:585883 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:585898 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:588170 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:588714 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:602811 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:606771 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:607020 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:607028 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:608938 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:609580 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:621478 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:626783 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:631077 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:631415 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:631428 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:633620 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:634151 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:639769 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:641837 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:645251 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:645662 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:650518 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:654443 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:655627 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:655994 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:658506 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:660369 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:660906 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:661166 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:666149 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:667100 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:667101 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:672173 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:672779 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:673248 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:683457 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:687903 "Isomerization of 3-trans-decenoyl-CoA to form trans-dec-2-enoyl-CoA" xref: Reactome:689017 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:689655 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:690030 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:700203 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:701397 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:701858 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:714618 "Reduction of 2-trans-4-cis-decadienoyl-CoA to form 3-trans-decenoyl-CoA" xref: Reactome:715968 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:716432 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:727917 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:732135 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:732977 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:733096 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:735522 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:737452 "dehydrogenation of 4-cis-decenoyl-CoA to form 2-trans-4-cis-decadienoyl-CoA" xref: Reactome:738254 "Removal of 2 Carbon atoms from trans,cis-Lauro-2,6-dienoyl-CoA to form 4-cis-decenoyl-CoA" xref: Reactome:738255 "Removal of six carbons from Linoleoyl-CoA to form cis,cis-3,6- Dodecadienoyl-CoA" xref: Reactome:738435 "Mitochondrial Fatty Acid Beta-Oxidation" xref: Reactome:738560 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:77288 "mitochondrial fatty acid beta-oxidation of unsaturated fatty acids" xref: Reactome:77289 "Mitochondrial Fatty Acid Beta-Oxidation" is_a: GO:0009062 ! fatty acid catabolic process is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0006636 name: unsaturated fatty acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of an unsaturated fatty acid, any fatty acid containing one or more double bonds between carbon atoms." [GOC:mah, MetaCyc:PWY-762, MetaCyc:PWY-782] subset: gosubset_prok synonym: "fatty acid desaturation" RELATED [] synonym: "unsaturated fatty acid anabolism" EXACT [] synonym: "unsaturated fatty acid biosynthesis" EXACT [] synonym: "unsaturated fatty acid formation" EXACT [] synonym: "unsaturated fatty acid synthesis" EXACT [] xref: MetaCyc:PWY-762 xref: MetaCyc:PWY-782 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006637 name: acyl-CoA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acyl-CoA metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0035383 ! thioester metabolic process [Term] id: GO:0006638 name: neutral lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving neutral lipids, lipids only soluble in solvents of very low polarity." [ISBN:0198547684] subset: gosubset_prok synonym: "neutral lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006639 name: acylglycerol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acylglycerol, any mono-, di- or triester of glycerol with (one or more) fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "acylglycerol metabolism" EXACT [] synonym: "glyceride metabolic process" EXACT [] synonym: "glyceride metabolism" EXACT [] is_a: GO:0006638 ! neutral lipid metabolic process is_a: GO:0006662 ! glycerol ether metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006640 name: monoacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of monoacylglycerol, any ester of glycerol in which any one of its hydroxyl groups has been acylated with a fatty acid, the other being non-esterified." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "monoacylglycerol anabolism" EXACT [] synonym: "monoacylglycerol biosynthesis" EXACT [] synonym: "monoacylglycerol formation" EXACT [] synonym: "monoacylglycerol synthesis" EXACT [] synonym: "monoglyceride biosynthesis" EXACT [] synonym: "monoglyceride biosynthetic process" EXACT [] is_a: GO:0046462 ! monoacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006641 name: triglyceride metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triglyceride, any triester of glycerol. The three fatty acid residues may all be the same or differ in any permutation. Triglycerides are important components of plant oils, animal fats and animal plasma lipoproteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "triacylglycerol metabolic process" EXACT [] synonym: "triacylglycerol metabolism" EXACT [] synonym: "triglyceride metabolism" EXACT [] is_a: GO:0006639 ! acylglycerol metabolic process [Term] id: GO:0006642 name: triglyceride mobilization namespace: biological_process def: "The release of triglycerides, any triester of glycerol, from storage within cells or tissues, making them available for metabolism." [GOC:mah, PMID:11943743, PMID:15713625] subset: gosubset_prok synonym: "triacylglycerol mobilization" EXACT [] is_a: GO:0006641 ! triglyceride metabolic process [Term] id: GO:0006643 name: membrane lipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving membrane lipids, any lipid found in or associated with a biological membrane." [GOC:ai] subset: gosubset_prok synonym: "membrane lipid metabolism" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006644 name: phospholipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid metabolism" EXACT [] is_a: GO:0019637 ! organophosphate metabolic process is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006646 name: phosphatidylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylethanolamine anabolism" EXACT [] synonym: "phosphatidylethanolamine biosynthesis" EXACT [] synonym: "phosphatidylethanolamine formation" EXACT [] synonym: "phosphatidylethanolamine synthesis" EXACT [] is_a: GO:0046335 ! ethanolamine biosynthetic process is_a: GO:0046337 ! phosphatidylethanolamine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006647 name: phosphatidyl-N-monomethylethanolamine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidyl-N-monomethylethanolamine (PMME), a derivative of phosphatidylethanolamine with a methylated amine group." [GOC:ai] subset: gosubset_prok synonym: "phosphatidyl-N-monomethylethanolamine anabolism" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine biosynthesis" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine formation" EXACT [] synonym: "phosphatidyl-N-monomethylethanolamine synthesis" EXACT [] synonym: "PMME biosynthesis" EXACT [] synonym: "PMME biosynthetic process" EXACT [] is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process is_a: GO:0046468 ! phosphatidyl-N-monomethylethanolamine metabolic process [Term] id: GO:0006648 name: dihydrosphingosine-1-P pathway namespace: biological_process subset: gosubset_prok is_a: GO:0006646 ! phosphatidylethanolamine biosynthetic process [Term] id: GO:0006649 name: phospholipid transfer to membrane namespace: biological_process def: "The transfer of a phospholipid from its site of synthesis to the plasma membrane." [GOC:go_curators] subset: gosubset_prok is_a: GO:0015914 ! phospholipid transport relationship: part_of GO:0016044 ! cellular membrane organization [Term] id: GO:0006650 name: glycerophospholipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerophospholipids, any derivative of glycerophosphate that contains at least one O-acyl, O-alkyl, or O-alkenyl group attached to the glycerol residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycerophospholipid metabolism" EXACT [] synonym: "phosphoglyceride metabolic process" EXACT [] synonym: "phosphoglyceride metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0046486 ! glycerolipid metabolic process [Term] id: GO:0006651 name: diacylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of diacylglycerol, a glycerol molecule substituted on the 1 and 2 hydroxyl groups with long chain fatty acyl residues." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "diacylglycerol anabolism" EXACT [] synonym: "diacylglycerol biosynthesis" EXACT [] synonym: "diacylglycerol formation" EXACT [] synonym: "diacylglycerol synthesis" EXACT [] is_a: GO:0046339 ! diacylglycerol metabolic process is_a: GO:0046463 ! acylglycerol biosynthetic process [Term] id: GO:0006652 name: alpha-glycerophosphate pathway namespace: biological_process subset: gosubset_prok is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0006653 name: lecithin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lecithin, any 3-sn-phosphatidylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lecithin metabolism" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process [Term] id: GO:0006654 name: phosphatidic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidic acid, any derivative of glycerol phosphate in which both the remaining hydroxyl groups of the glycerol moiety are esterified with fatty acids." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidic acid anabolism" EXACT [] synonym: "phosphatidic acid biosynthesis" EXACT [] synonym: "phosphatidic acid formation" EXACT [] synonym: "phosphatidic acid synthesis" EXACT [] is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046473 ! phosphatidic acid metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006655 name: phosphatidylglycerol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylglycerols, any of a class of phospholipids in which the phosphatidyl group is esterified to the hydroxyl group of glycerol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylglycerol anabolism" EXACT [] synonym: "phosphatidylglycerol biosynthesis" EXACT [] synonym: "phosphatidylglycerol formation" EXACT [] synonym: "phosphatidylglycerol synthesis" EXACT [] is_a: GO:0046471 ! phosphatidylglycerol metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006656 name: phosphatidylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylcholines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylcholine anabolism" EXACT [] synonym: "phosphatidylcholine biosynthesis" EXACT [] synonym: "phosphatidylcholine formation" EXACT [] synonym: "phosphatidylcholine synthesis" EXACT [] is_a: GO:0046470 ! phosphatidylcholine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006657 name: CDP-choline pathway namespace: biological_process def: "The phosphatidylcholine biosynthetic process that begins with the phosphorylation of choline and ends with the combination of CDP-choline with diacylglycerol to form phosphatidylcholine." [ISBN:0471331309 "Biochemical Pathways", MetaCyc:PWY3O-450] subset: gosubset_prok synonym: "Kennedy pathway" EXACT [MetaCyc:PWY3O-450] synonym: "phosphatidylcholine biosynthesis from choline" EXACT [GOC:mah, MetaCyc:PWY3O-450] xref: MetaCyc:PWY3O-450 is_a: GO:0006656 ! phosphatidylcholine biosynthetic process [Term] id: GO:0006658 name: phosphatidylserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine. They are important constituents of cell membranes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine metabolism" EXACT [] is_a: GO:0006650 ! glycerophospholipid metabolic process [Term] id: GO:0006659 name: phosphatidylserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine anabolism" EXACT [] synonym: "phosphatidylserine biosynthesis" EXACT [] synonym: "phosphatidylserine formation" EXACT [] synonym: "phosphatidylserine synthesis" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006660 name: phosphatidylserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phosphatidylserines, any of a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of L-serine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylserine breakdown" EXACT [] synonym: "phosphatidylserine catabolism" EXACT [] synonym: "phosphatidylserine degradation" EXACT [] is_a: GO:0006658 ! phosphatidylserine metabolic process is_a: GO:0046475 ! glycerophospholipid catabolic process [Term] id: GO:0006661 name: phosphatidylinositol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phosphatidylinositol anabolism" EXACT [] synonym: "phosphatidylinositol biosynthesis" EXACT [] synonym: "phosphatidylinositol formation" EXACT [] synonym: "phosphatidylinositol synthesis" EXACT [] synonym: "PtdIns biosynthesis" EXACT [] synonym: "PtdIns biosynthetic process" EXACT [] is_a: GO:0046488 ! phosphatidylinositol metabolic process is_a: GO:0046489 ! phosphoinositide biosynthetic process [Term] id: GO:0006662 name: glycerol ether metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycerol ethers, any anhydride formed between two organic hydroxy compounds, one of which is glycerol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "glycerol ether metabolism" EXACT [] is_a: GO:0018904 ! organic ether metabolic process [Term] id: GO:0006663 name: platelet activating factor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of platelet activating factor, 1-O-alkyl-2-acetyl-sn-glycerol 3-phosphocholine, where alkyl = hexadecyl or octadecyl. Platelet activating factor is an inflammatory mediator released from a variety of cells in response to various stimuli." [ISBN:0198547684] synonym: "PAF biosynthesis" EXACT [] synonym: "PAF biosynthetic process" EXACT [] synonym: "platelet activating factor anabolism" EXACT [] synonym: "platelet activating factor biosynthesis" EXACT [] synonym: "platelet activating factor formation" EXACT [] synonym: "platelet activating factor synthesis" EXACT [] is_a: GO:0046469 ! platelet activating factor metabolic process is_a: GO:0046474 ! glycerophospholipid biosynthetic process [Term] id: GO:0006664 name: glycolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolipids, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide). Some substances classified as bacterial glycolipids have the sugar moiety acylated by one or more fatty acids and the glycerol moiety may be absent." [CHEBI:33563, ISBN:0198547684] subset: gosubset_prok synonym: "glycolipid metabolism" EXACT [] is_a: GO:0006643 ! membrane lipid metabolic process [Term] id: GO:0006665 name: sphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid)." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingolipid metabolism" EXACT [] xref: Reactome:428157 "Sphingolipid metabolism" xref: Reactome:562616 "Sphingolipid metabolism" xref: Reactome:588242 "Sphingolipid metabolism" xref: Reactome:609001 "Sphingolipid metabolism" xref: Reactome:633689 "Sphingolipid metabolism" xref: Reactome:645301 "Sphingolipid metabolism" xref: Reactome:655935 "Sphingolipid metabolism" xref: Reactome:660955 "Sphingolipid metabolism" xref: Reactome:666727 "Sphingolipid metabolism" xref: Reactome:672832 "Sphingolipid metabolism" xref: Reactome:678552 "Sphingolipid metabolism" xref: Reactome:683513 "Sphingolipid metabolism" xref: Reactome:689715 "Sphingolipid metabolism" xref: Reactome:701447 "Sphingolipid metabolism" xref: Reactome:716018 "Sphingolipid metabolism" xref: Reactome:720670 "Sphingolipid metabolism" xref: Reactome:727965 "Sphingolipid metabolism" xref: Reactome:730912 "Sphingolipid metabolism" xref: Reactome:733950 "Sphingolipid metabolism" xref: Reactome:738478 "Sphingolipid metabolism" is_a: GO:0006643 ! membrane lipid metabolic process [Term] id: GO:0006666 name: 3-keto-sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 3-keto-sphinganine, a derivative of sphinganine with a ketone group at C3. It is an intermediate in the synthesis of sphingosine." [GOC:ai] subset: gosubset_prok synonym: "3-keto-dihydrosphingosine metabolic process" EXACT [] synonym: "3-keto-dihydrosphingosine metabolism" EXACT [] synonym: "3-keto-sphinganine metabolism" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006667 name: sphinganine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine, D-erythro-2-amino-1,3-octadecanediol." [http://www.chem.qmul.ac.uk/iupac/lipid/lip1n2.html#p18] subset: gosubset_prok synonym: "dihydrosphingosine metabolic process" EXACT [] synonym: "dihydrosphingosine metabolism" EXACT [] synonym: "sphinganine metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006668 name: sphinganine-1-phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] subset: gosubset_prok synonym: "dihydrosphingosine-1-phosphate metabolic process" EXACT [] synonym: "dihydrosphingosine-1-phosphate metabolism" EXACT [] synonym: "sphinganine-1-phosphate metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006667 ! sphinganine metabolic process [Term] id: GO:0006669 name: sphinganine-1-phosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphinganine-1-phosphate, the phosphorylated derivative of D-erythro-2-amino-1,3-octadecanediol." [GOC:ai] subset: gosubset_prok synonym: "dihydrosphingosine-1-phosphate biosynthesis" EXACT [] synonym: "dihydrosphingosine-1-phosphate biosynthetic process" EXACT [] synonym: "sphinganine-1-phosphate anabolism" EXACT [] synonym: "sphinganine-1-phosphate biosynthesis" EXACT [] synonym: "sphinganine-1-phosphate formation" EXACT [] synonym: "sphinganine-1-phosphate synthesis" EXACT [] is_a: GO:0006668 ! sphinganine-1-phosphate metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046511 ! sphinganine biosynthetic process [Term] id: GO:0006670 name: sphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues." [GOC:ma, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "(4E)-sphing-4-enine metabolic process" EXACT [] synonym: "(4E)-sphing-4-enine metabolism" EXACT [] synonym: "sphing-4-enine metabolic process" EXACT [] synonym: "sphing-4-enine metabolism" EXACT [] synonym: "sphingosine metabolism" EXACT [] is_a: GO:0006066 ! alcohol metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006671 name: phytosphingosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving phytosphingosine, (2S,3S,4R)-2-aminooctadecane-1,3,4-triol, a constituent of many plant sphingolipids." [ChEBI:46961, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phytosphingosine metabolism" EXACT [] is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006672 name: ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ceramides, any N-acylated sphingoid." [ISBN:0198547684] subset: gosubset_prok synonym: "ceramide metabolism" EXACT [] is_a: GO:0046519 ! sphingoid metabolic process [Term] id: GO:0006673 name: inositolphosphoceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositolphosphoceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety." [http://www.chem.qmul.ac.uk/iupac/misc/glylp.html] subset: gosubset_prok synonym: "inositolphosphoceramide metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006672 ! ceramide metabolic process [Term] id: GO:0006674 name: inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving inositol phosphorylceramides, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety. The phosphate-containing moiety is the trivalent -P(O)= and the ceramide moiety of this lipid consists of phytosphingosine and a hydroxy C26 fatty acid." [http://www.cyberlipid.org/] subset: gosubset_prok synonym: "inositol phosphorylceramide metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006675 name: mannosyl-inositol phosphorylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl-inositol phosphorylceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains a phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai, MetaCyc:MIPC] subset: gosubset_prok synonym: "mannose inositol phosphoceramide metabolic process" EXACT [] synonym: "mannose inositol phosphoceramide metabolism" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolic process" EXACT [] synonym: "mannose-inositol-P-ceramide (MIPC) metabolism" EXACT [] synonym: "mannosyl-inositol-phosphorylceramide metabolism" EXACT [] synonym: "MIPC metabolic process" EXACT [] synonym: "MIPC metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006676 name: mannosyl diphosphorylinositol ceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannosyl diphosphorylinositol ceramide, any lipid with a phosphodiester bridge between an inositol residue and the ceramide moiety which contains two phosphoryl (-P(O)=) groups and a mannose derivative." [GOC:ai] subset: gosubset_prok synonym: "M(IP)2C metabolic process" EXACT [] synonym: "M(IP)2C metabolism" EXACT [] synonym: "mannosyl diphosphorylinositol ceramide metabolism" EXACT [] is_a: GO:0006673 ! inositolphosphoceramide metabolic process [Term] id: GO:0006677 name: glycosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of a monosaccharide (or derivative) by a ceramide group." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycosylceramide metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006672 ! ceramide metabolic process [Term] id: GO:0006678 name: glucosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group. They are neutral glycolipids containing equimolar amounts of fatty acid, glucose, and sphingosine or a sphingosine derivative." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glucosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process [Term] id: GO:0006679 name: glucosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glucosylceramide anabolism" EXACT [] synonym: "glucosylceramide biosynthesis" EXACT [] synonym: "glucosylceramide formation" EXACT [] synonym: "glucosylceramide synthesis" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006680 name: glucosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of glucose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "glucosylceramide breakdown" EXACT [] synonym: "glucosylceramide catabolism" EXACT [] synonym: "glucosylceramide degradation" EXACT [] is_a: GO:0006678 ! glucosylceramide metabolic process is_a: GO:0046477 ! glycosylceramide catabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006681 name: galactosylceramide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide metabolism" EXACT [] is_a: GO:0006677 ! glycosylceramide metabolic process is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0019374 ! galactolipid metabolic process [Term] id: GO:0006682 name: galactosylceramide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide anabolism" EXACT [] synonym: "galactosylceramide biosynthesis" EXACT [] synonym: "galactosylceramide formation" EXACT [] synonym: "galactosylceramide synthesis" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0006688 ! glycosphingolipid biosynthetic process is_a: GO:0019375 ! galactolipid biosynthetic process is_a: GO:0046476 ! glycosylceramide biosynthetic process [Term] id: GO:0006683 name: galactosylceramide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of galactosylceramides, any compound formed by the replacement of the glycosidic hydroxyl group of a cyclic form of galactose by a ceramide group." [GOC:ai] subset: gosubset_prok synonym: "galactosylceramide breakdown" EXACT [] synonym: "galactosylceramide catabolism" EXACT [] synonym: "galactosylceramide degradation" EXACT [] is_a: GO:0006681 ! galactosylceramide metabolic process is_a: GO:0019376 ! galactolipid catabolic process is_a: GO:0046477 ! glycosylceramide catabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006684 name: sphingomyelin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine, any of a class of phospholipids in which the amino group of sphingosine is in amide linkage with one of several fatty acids, while the terminal hydroxyl group of sphingosine is esterified to phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin metabolism" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006685 name: sphingomyelin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin breakdown" EXACT [] synonym: "sphingomyelin catabolism" EXACT [] synonym: "sphingomyelin degradation" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0009395 ! phospholipid catabolic process is_a: GO:0030149 ! sphingolipid catabolic process [Term] id: GO:0006686 name: sphingomyelin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of sphingomyelin, N-acyl-4-sphingenyl-1-O-phosphorylcholine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "sphingomyelin anabolism" EXACT [] synonym: "sphingomyelin biosynthesis" EXACT [] synonym: "sphingomyelin formation" EXACT [] synonym: "sphingomyelin synthesis" EXACT [] is_a: GO:0006684 ! sphingomyelin metabolic process is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046513 ! ceramide biosynthetic process [Term] id: GO:0006687 name: glycosphingolipid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycosphingolipids, any compound with residues of sphingoid and at least one monosaccharide." [ISBN:0198547684] subset: gosubset_prok synonym: "glycosphingolipid metabolism" EXACT [] is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0006665 ! sphingolipid metabolic process [Term] id: GO:0006688 name: glycosphingolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycosphingolipid, a compound with residues of sphingoid and at least one monosaccharide." [GOC:go_curators] subset: gosubset_prok synonym: "glycosphingolipid anabolism" EXACT [] synonym: "glycosphingolipid biosynthesis" EXACT [] synonym: "glycosphingolipid formation" EXACT [] synonym: "glycosphingolipid synthesis" EXACT [] is_a: GO:0006687 ! glycosphingolipid metabolic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0030148 ! sphingolipid biosynthetic process [Term] id: GO:0006689 name: ganglioside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ganglioside, a ceramide oligosaccharide carrying, in addition to other sugar residues, one or more sialic residues." [ISBN:0198547684] subset: gosubset_prok synonym: "ganglioside breakdown" EXACT [] synonym: "ganglioside catabolism" EXACT [] synonym: "ganglioside degradation" EXACT [] is_a: GO:0001573 ! ganglioside metabolic process is_a: GO:0046479 ! glycosphingolipid catabolic process [Term] id: GO:0006690 name: icosanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving icosanoids, any of a group of C20 polyunsaturated fatty acids." [GOC:ma] subset: gosubset_prok synonym: "eicosanoid metabolic process" EXACT [] synonym: "eicosanoid metabolism" EXACT [] synonym: "icosanoid metabolism" EXACT [] is_a: GO:0033559 ! unsaturated fatty acid metabolic process [Term] id: GO:0006691 name: leukotriene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid." [GOC:ma] subset: gosubset_prok synonym: "leukotriene metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0006692 name: prostanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostanoids, any compound based on or derived from the prostanoate structure." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "prostanoid metabolism" EXACT [] is_a: GO:0006690 ! icosanoid metabolic process [Term] id: GO:0006693 name: prostaglandin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving prostaglandins, any of a group of biologically active metabolites which contain a cyclopentane ring due to the formation of a bond between two carbons of a fatty acid. They have a wide range of biological activities." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "prostaglandin metabolism" EXACT [] is_a: GO:0006692 ! prostanoid metabolic process [Term] id: GO:0006694 name: steroid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus; includes de novo formation and steroid interconversion by modification." [GOC:go_curators] subset: gosubset_prok synonym: "steroid anabolism" EXACT [] synonym: "steroid biosynthesis" EXACT [] synonym: "steroid formation" EXACT [] synonym: "steroid synthesis" EXACT [] synonym: "steroidogenesis" EXACT [] xref: Reactome:196071 "Steroid hormone biosynthesis" xref: Reactome:562573 "Steroid hormone biosynthesis" xref: Reactome:588199 "Steroid hormone biosynthesis" xref: Reactome:608963 "Steroid hormone biosynthesis" xref: Reactome:633645 "Steroid hormone biosynthesis" xref: Reactome:645273 "Steroid hormone biosynthesis" xref: Reactome:655939 "Steroid hormone biosynthesis" xref: Reactome:661324 "Steroid hormone biosynthesis" xref: Reactome:667103 "Steroid hormone biosynthesis" xref: Reactome:673250 "Steroid hormone biosynthesis" xref: Reactome:678936 "Steroid hormone biosynthesis" xref: Reactome:683858 "Steroid hormone biosynthesis" xref: Reactome:690076 "Steroid hormone biosynthesis" xref: Reactome:701795 "Steroid hormone biosynthesis" xref: Reactome:716370 "Steroid hormone biosynthesis" xref: Reactome:720935 "Steroid hormone biosynthesis" xref: Reactome:728353 "Steroid hormone biosynthesis" xref: Reactome:731171 "Steroid hormone biosynthesis" xref: Reactome:738608 "Steroid hormone biosynthesis" xref: Wikipedia:Steroid_metabolisms#Steroid_biosynthesis is_a: GO:0008202 ! steroid metabolic process is_a: GO:0008610 ! lipid biosynthetic process [Term] id: GO:0006695 name: cholesterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol anabolism" EXACT [] synonym: "cholesterol biosynthesis" EXACT [] synonym: "cholesterol formation" EXACT [] synonym: "cholesterol synthesis" EXACT [] xref: Reactome:191273 "Cholesterol biosynthesis" xref: Reactome:191345 "Transformation of lanosterol to cholesterol" xref: Reactome:562617 "Transformation of lanosterol to cholesterol" xref: Reactome:562618 "Cholesterol biosynthesis" xref: Reactome:588243 "Transformation of lanosterol to cholesterol" xref: Reactome:588244 "Cholesterol biosynthesis" xref: Reactome:609002 "Transformation of lanosterol to cholesterol" xref: Reactome:609003 "Cholesterol biosynthesis" xref: Reactome:633690 "Transformation of lanosterol to cholesterol" xref: Reactome:633691 "Cholesterol biosynthesis" xref: Reactome:645305 "Transformation of lanosterol to cholesterol" xref: Reactome:645306 "Cholesterol biosynthesis" xref: Reactome:655677 "Transformation of lanosterol to cholesterol" xref: Reactome:655678 "Cholesterol biosynthesis" xref: Reactome:660956 "Transformation of lanosterol to cholesterol" xref: Reactome:660957 "Cholesterol biosynthesis" xref: Reactome:666728 "Transformation of lanosterol to cholesterol" xref: Reactome:666729 "Cholesterol biosynthesis" xref: Reactome:672833 "Transformation of lanosterol to cholesterol" xref: Reactome:672834 "Cholesterol biosynthesis" xref: Reactome:678553 "Transformation of lanosterol to cholesterol" xref: Reactome:678554 "Cholesterol biosynthesis" xref: Reactome:683514 "Transformation of lanosterol to cholesterol" xref: Reactome:683515 "Cholesterol biosynthesis" xref: Reactome:689716 "Transformation of lanosterol to cholesterol" xref: Reactome:689717 "Cholesterol biosynthesis" xref: Reactome:701448 "Transformation of lanosterol to cholesterol" xref: Reactome:701449 "Cholesterol biosynthesis" xref: Reactome:716019 "Transformation of lanosterol to cholesterol" xref: Reactome:716020 "Cholesterol biosynthesis" xref: Reactome:727966 "Transformation of lanosterol to cholesterol" xref: Reactome:727967 "Cholesterol biosynthesis" xref: Reactome:733036 "Cholesterol biosynthesis" xref: Reactome:733905 "Cholesterol biosynthesis" xref: Reactome:735568 "Transformation of lanosterol to cholesterol" xref: Reactome:735569 "Cholesterol biosynthesis" xref: Reactome:738479 "Transformation of lanosterol to cholesterol" xref: Reactome:738480 "Cholesterol biosynthesis" is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process [Term] id: GO:0006696 name: ergosterol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ergosterol anabolism" EXACT [] synonym: "ergosterol biosynthesis" EXACT [] synonym: "ergosterol formation" EXACT [] synonym: "ergosterol synthesis" EXACT [] is_a: GO:0008204 ! ergosterol metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0016129 ! phytosteroid biosynthetic process [Term] id: GO:0006697 name: ecdysone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone anabolism" EXACT [] synonym: "ecdysone biosynthesis" EXACT [] synonym: "ecdysone formation" EXACT [] synonym: "ecdysone synthesis" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016126 ! sterol biosynthetic process is_a: GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0006698 name: ecdysone modification namespace: biological_process def: "OBSOLETE. The covalent or conformational alteration of ecdysone, resulting in a change in its properties." [GOC:jl] comment: This term was made obsolete because it was created to cover the conversion of ecdysone to its active form ecdysterone (20-hydroxyecdysone), but this reaction is carried out in a single step by ecdysone 20-monooxygenase (EC 1.14.99.22) and so is a function rather than a process. is_obsolete: true replaced_by: GO:0004501 [Term] id: GO:0006699 name: bile acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of bile acids, any of a group of steroid carboxylic acids occurring in bile." [GOC:go_curators] synonym: "bile acid anabolism" EXACT [] synonym: "bile acid biosynthesis" EXACT [] synonym: "bile acid formation" EXACT [] synonym: "bile acid synthesis" EXACT [] xref: Reactome:192105 "Synthesis of bile acids and bile salts" xref: Reactome:193368 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:193775 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:193807 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:562520 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:562521 "Synthesis of bile acids and bile salts" xref: Reactome:562598 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:562603 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:588146 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:588147 "Synthesis of bile acids and bile salts" xref: Reactome:588224 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:588229 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:608914 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:608915 "Synthesis of bile acids and bile salts" xref: Reactome:608988 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:608992 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:633596 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:633597 "Synthesis of bile acids and bile salts" xref: Reactome:633675 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:633687 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:645228 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:645229 "Synthesis of bile acids and bile salts" xref: Reactome:645299 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:645307 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:655602 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:655603 "Synthesis of bile acids and bile salts" xref: Reactome:655675 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:655679 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:660890 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:660891 "Synthesis of bile acids and bile salts" xref: Reactome:660958 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:660959 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:666673 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:666674 "Synthesis of bile acids and bile salts" xref: Reactome:666724 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:666730 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:672765 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:672766 "Synthesis of bile acids and bile salts" xref: Reactome:672829 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:672835 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:678556 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:678557 "Synthesis of bile acids and bile salts" xref: Reactome:678559 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:678560 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:683493 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:683494 "Synthesis of bile acids and bile salts" xref: Reactome:683516 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:683517 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:689696 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:689697 "Synthesis of bile acids and bile salts" xref: Reactome:689718 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:689719 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:701379 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:701380 "Synthesis of bile acids and bile salts" xref: Reactome:701450 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:701451 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:715950 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:715951 "Synthesis of bile acids and bile salts" xref: Reactome:716021 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:716022 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:720671 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:720672 "Synthesis of bile acids and bile salts" xref: Reactome:720675 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:720676 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:727900 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:727901 "Synthesis of bile acids and bile salts" xref: Reactome:727968 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:727969 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:731190 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:731191 "Synthesis of bile acids and bile salts" xref: Reactome:733003 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:733004 "Synthesis of bile acids and bile salts" xref: Reactome:733007 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:733008 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:733951 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:733952 "Synthesis of bile acids and bile salts" xref: Reactome:735563 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:735564 "Synthesis of bile acids and bile salts" xref: Reactome:735570 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:735571 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" xref: Reactome:736633 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:736634 "Synthesis of bile acids and bile salts" xref: Reactome:738422 "Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol" xref: Reactome:738423 "Synthesis of bile acids and bile salts" xref: Reactome:738476 "Synthesis of bile acids and bile salts via 24-hydroxycholesterol" xref: Reactome:738481 "Synthesis of bile acids and bile salts via 27-hydroxycholesterol" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008206 ! bile acid metabolic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0006700 name: C21-steroid hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone anabolism" EXACT [] synonym: "C21-steroid hormone biosynthesis" EXACT [] synonym: "C21-steroid hormone formation" EXACT [] synonym: "C21-steroid hormone synthesis" EXACT [] is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006701 name: progesterone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone anabolism" EXACT [] synonym: "progesterone biosynthesis" EXACT [] synonym: "progesterone formation" EXACT [] synonym: "progesterone synthesis" EXACT [] xref: Reactome:196108 "Pregnenolone biosynthesis" xref: Reactome:562596 "Pregnenolone biosynthesis" xref: Reactome:588222 "Pregnenolone biosynthesis" xref: Reactome:608983 "Pregnenolone biosynthesis" xref: Reactome:633665 "Pregnenolone biosynthesis" xref: Reactome:655938 "Pregnenolone biosynthesis" is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006702 name: androgen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen anabolism" EXACT [] synonym: "androgen biosynthesis" EXACT [] synonym: "androgen formation" EXACT [] synonym: "androgen synthesis" EXACT [] xref: Reactome:193048 "Androgen biosynthesis" xref: Reactome:563108 "Androgen biosynthesis" xref: Reactome:588720 "Androgen biosynthesis" xref: Reactome:609458 "Androgen biosynthesis" xref: Reactome:634157 "Androgen biosynthesis" xref: Reactome:645668 "Androgen biosynthesis" xref: Reactome:656077 "Androgen biosynthesis" xref: Reactome:661323 "Androgen biosynthesis" xref: Reactome:667102 "Androgen biosynthesis" xref: Reactome:673249 "Androgen biosynthesis" xref: Reactome:678935 "Androgen biosynthesis" xref: Reactome:683857 "Androgen biosynthesis" xref: Reactome:690111 "Androgen biosynthesis" xref: Reactome:701794 "Androgen biosynthesis" xref: Reactome:716369 "Androgen biosynthesis" xref: Reactome:720934 "Androgen biosynthesis" xref: Reactome:728387 "Androgen biosynthesis" xref: Reactome:731170 "Androgen biosynthesis" xref: Reactome:738617 "Androgen biosynthesis" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006703 name: estrogen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "estrogen anabolism" EXACT [] synonym: "estrogen biosynthesis" EXACT [] synonym: "estrogen formation" EXACT [] synonym: "estrogen synthesis" EXACT [] synonym: "oestrogen biosynthesis" EXACT [] synonym: "oestrogen biosynthetic process" EXACT [] xref: Reactome:193144 "Estrogen biosynthesis" xref: Reactome:562839 "Estrogen biosynthesis" xref: Reactome:588459 "Estrogen biosynthesis" xref: Reactome:609198 "Estrogen biosynthesis" xref: Reactome:633891 "Estrogen biosynthesis" is_a: GO:0006694 ! steroid biosynthetic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006704 name: glucocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid anabolism" EXACT [] synonym: "glucocorticoid biosynthesis" EXACT [] synonym: "glucocorticoid formation" EXACT [] synonym: "glucocorticoid synthesis" EXACT [] xref: Reactome:194002 "Glucocorticoid biosynthesis" xref: Reactome:562572 "Glucocorticoid biosynthesis" xref: Reactome:588198 "Glucocorticoid biosynthesis" xref: Reactome:608962 "Glucocorticoid biosynthesis" xref: Reactome:633644 "Glucocorticoid biosynthesis" xref: Reactome:645272 "Glucocorticoid biosynthesis" xref: Reactome:656078 "Glucocorticoid biosynthesis" xref: Reactome:690075 "Glucocorticoid biosynthesis" xref: Reactome:701797 "Glucocorticoid biosynthesis" xref: Reactome:716372 "Glucocorticoid biosynthesis" xref: Reactome:728352 "Glucocorticoid biosynthesis" xref: Reactome:738607 "Glucocorticoid biosynthesis" is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006705 name: mineralocorticoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid anabolism" EXACT [] synonym: "mineralocorticoid biosynthesis" EXACT [] synonym: "mineralocorticoid formation" EXACT [] synonym: "mineralocorticoid synthesis" EXACT [] xref: Reactome:193993 "Mineralocorticoid biosynthesis" xref: Reactome:562597 "Mineralocorticoid biosynthesis" xref: Reactome:588223 "Mineralocorticoid biosynthesis" xref: Reactome:609691 "Mineralocorticoid biosynthesis" xref: Reactome:633670 "Mineralocorticoid biosynthesis" xref: Reactome:645848 "Mineralocorticoid biosynthesis" is_a: GO:0006700 ! C21-steroid hormone biosynthetic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006706 name: steroid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [GOC:go_curators] subset: gosubset_prok synonym: "steroid breakdown" EXACT [] synonym: "steroid catabolism" EXACT [] synonym: "steroid degradation" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0016042 ! lipid catabolic process [Term] id: GO:0006707 name: cholesterol catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones." [GOC:ai] synonym: "cholesterol breakdown" EXACT [] synonym: "cholesterol catabolism" EXACT [] synonym: "cholesterol degradation" EXACT [] is_a: GO:0008203 ! cholesterol metabolic process is_a: GO:0016127 ! sterol catabolic process [Term] id: GO:0006708 name: ecdysone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone breakdown" EXACT [] synonym: "ecdysone catabolism" EXACT [] synonym: "ecdysone degradation" EXACT [] is_a: GO:0008205 ! ecdysone metabolic process is_a: GO:0016127 ! sterol catabolic process is_a: GO:0046344 ! ecdysteroid catabolic process [Term] id: GO:0006709 name: progesterone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants." [GOC:jl, http://www.cogsci.princeton.edu/] synonym: "progesterone breakdown" EXACT [] synonym: "progesterone catabolism" EXACT [] synonym: "progesterone degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0042448 ! progesterone metabolic process [Term] id: GO:0006710 name: androgen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen breakdown" EXACT [] synonym: "androgen catabolism" EXACT [] synonym: "androgen degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008209 ! androgen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006711 name: estrogen catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "estrogen breakdown" EXACT [] synonym: "estrogen catabolism" EXACT [] synonym: "estrogen degradation" EXACT [] synonym: "oestrogen catabolic process" EXACT [] synonym: "oestrogen catabolism" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008210 ! estrogen metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006712 name: mineralocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid breakdown" EXACT [] synonym: "mineralocorticoid catabolism" EXACT [] synonym: "mineralocorticoid degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0008212 ! mineralocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006713 name: glucocorticoid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid breakdown" EXACT [] synonym: "glucocorticoid catabolism" EXACT [] synonym: "glucocorticoid degradation" EXACT [] is_a: GO:0008208 ! C21-steroid hormone catabolic process is_a: GO:0008211 ! glucocorticoid metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006714 name: sesquiterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving sesquiterpenoid compounds, terpenoids with three isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "sesquiterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process is_a: GO:0051761 ! sesquiterpene metabolic process [Term] id: GO:0006715 name: farnesol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the sesquiterpenoid alcohol farnesol, 3,7,11-trimethyl-2,6,10,dodecatrien-1-ol." [ISBN:0198547684] subset: gosubset_prok synonym: "farnesol anabolism" EXACT [] synonym: "farnesol biosynthesis" EXACT [] synonym: "farnesol formation" EXACT [] synonym: "farnesol synthesis" EXACT [] is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0016487 ! farnesol metabolic process is_a: GO:0034309 ! monohydric alcohol biosynthetic process [Term] id: GO:0006716 name: juvenile hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0006717 name: juvenile hormone binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true consider: GO:0005500 [Term] id: GO:0006718 name: juvenile hormone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone anabolism" EXACT [] synonym: "juvenile hormone biosynthesis" EXACT [] synonym: "juvenile hormone formation" EXACT [] synonym: "juvenile hormone synthesis" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0042446 ! hormone biosynthetic process [Term] id: GO:0006719 name: juvenile hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of juvenile hormones, the three sesquiterpenoid derivatives that function to maintain the larval state of insects at molting and that may be required for other processes, e.g. oogenesis." [GOC:go_curators, ISBN:0198547684] synonym: "juvenile hormone breakdown" EXACT [] synonym: "juvenile hormone catabolism" EXACT [] synonym: "juvenile hormone degradation" EXACT [] is_a: GO:0006716 ! juvenile hormone metabolic process is_a: GO:0016107 ! sesquiterpenoid catabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0006720 name: isoprenoid metabolic process namespace: biological_process alt_id: GO:0016096 def: "The chemical reactions and pathways involving isoprenoid compounds, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198547684] subset: gosubset_prok synonym: "isoprenoid metabolism" EXACT [] synonym: "polyisoprenoid metabolic process" NARROW [] synonym: "polyisoprenoid metabolism" NARROW [] synonym: "polyterpene metabolic process" NARROW [] synonym: "polyterpene metabolism" NARROW [] is_a: GO:0044255 ! cellular lipid metabolic process [Term] id: GO:0006721 name: terpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving terpenoids, any member of a class of compounds characterized by an isoprenoid chemical structure and including derivatives with various functional groups." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "terpenoid metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0006722 name: triterpenoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving triterpenoid compounds, terpenoids with six isoprene units." [ISBN:0198547684] subset: gosubset_prok synonym: "triterpene metabolic process" NARROW [] synonym: "triterpene metabolism" NARROW [] synonym: "triterpenoid metabolism" EXACT [] is_a: GO:0006721 ! terpenoid metabolic process [Term] id: GO:0006723 name: cuticle hydrocarbon biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of hydrocarbons that make up the cuticle, the outer layer of some animals and plants, which acts to prevent water loss." [GOC:ai] synonym: "cuticle hydrocarbon anabolism" EXACT [] synonym: "cuticle hydrocarbon biosynthesis" EXACT [] synonym: "cuticle hydrocarbon formation" EXACT [] synonym: "cuticle hydrocarbon synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process relationship: part_of GO:0042335 ! cuticle development [Term] id: GO:0006725 name: cellular aromatic compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic compounds, any organic compound characterized by one or more planar rings, each of which contains conjugated double bonds and delocalized pi electrons, as carried out by individual cells." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "aromatic compound metabolism" EXACT [] synonym: "aromatic hydrocarbon metabolic process" NARROW [] synonym: "aromatic hydrocarbon metabolism" NARROW [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006726 name: eye pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of eye pigments, any general or particular coloring matter in living organisms, found or utilized in the eye." [GOC:ai] synonym: "eye pigment anabolism" EXACT [] synonym: "eye pigment biosynthesis" EXACT [] synonym: "eye pigment formation" EXACT [] synonym: "eye pigment synthesis" EXACT [] is_a: GO:0042441 ! eye pigment metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006727 name: ommochrome biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ommochromes, any of a large group of natural polycyclic pigments commonly found in the Arthropoda, particularly in the ommatidia of the compound eye." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ommochrome anabolism" EXACT [] synonym: "ommochrome biosynthesis" EXACT [] synonym: "ommochrome formation" EXACT [] synonym: "ommochrome synthesis" EXACT [] is_a: GO:0006726 ! eye pigment biosynthetic process is_a: GO:0008055 ! ocellus pigment biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046152 ! ommochrome metabolic process [Term] id: GO:0006728 name: pteridine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pteridine, pyrazino(2,3-dipyrimidine), the parent structure of pterins and the pteroyl group." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pteridine anabolism" EXACT [] synonym: "pteridine biosynthesis" EXACT [] synonym: "pteridine formation" EXACT [] synonym: "pteridine synthesis" EXACT [] synonym: "pterin biosynthesis" NARROW [] synonym: "pterin biosynthetic process" NARROW [] is_a: GO:0019889 ! pteridine metabolic process is_a: GO:0042559 ! pteridine and derivative biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006729 name: tetrahydrobiopterin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tetrahydrobiopterin, the reduced form of biopterin (2-amino-4-hydroxy-6-(1,2-dihydroxypropyl)-pteridine). It functions as a hydroxylation coenzyme, e.g. in the conversion of phenylalanine to tyrosine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tetrahydrobiopterin anabolism" EXACT [] synonym: "tetrahydrobiopterin biosynthesis" EXACT [] synonym: "tetrahydrobiopterin formation" EXACT [] synonym: "tetrahydrobiopterin synthesis" EXACT [] is_a: GO:0042559 ! pteridine and derivative biosynthetic process is_a: GO:0046146 ! tetrahydrobiopterin metabolic process [Term] id: GO:0006730 name: one-carbon metabolic process namespace: biological_process alt_id: GO:0019753 alt_id: GO:0019754 def: "The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states." [GOC:hjd, GOC:mah, GOC:pde] subset: goslim_pir subset: gosubset_prok synonym: "one carbon metabolic process" EXACT [GOC:mah] synonym: "one carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon metabolism" EXACT [GOC:mah] synonym: "one-carbon transfer metabolic process" EXACT [GOC:mah] synonym: "one-carbon transfer metabolism" EXACT [GOC:mah] xref: UM-BBD_pathwayID:C1cyc is_a: GO:0044237 ! cellular metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006731 name: coenzyme and prosthetic group metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving coenzymes and prosthetic groups." [GOC:ai] comment: This term was made obsolete because it was replaced by more specific terms. is_obsolete: true consider: GO:0006732 consider: GO:0051189 [Term] id: GO:0006732 name: coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "coenzyme and prosthetic group metabolic process" BROAD [] synonym: "coenzyme and prosthetic group metabolism" BROAD [] synonym: "coenzyme metabolism" EXACT [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006733 name: oxidoreduction coenzyme metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coenzymes that are required, in addition to an enzyme and a substrate, for an oxidoreductase reaction to proceed." [GOC:mah] subset: gosubset_prok synonym: "oxidoreduction coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006734 name: NADH metabolic process namespace: biological_process def: "The chemical reactions and pathways involving reduced nicotinamide adenine dinucleotide (NADH), a coenzyme present in most living cells and derived from the B vitamin nicotinic acid." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (reduced) metabolic process" EXACT [] synonym: "NAD (reduced) metabolism" EXACT [] synonym: "NADH metabolism" EXACT [] synonym: "reduced NAD metabolic process" EXACT [] synonym: "reduced NAD metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide metabolism" EXACT [] is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0006735 name: NADH regeneration namespace: biological_process def: "A metabolic process by which a pool of NADH generated by the reduction of NAD+." [GOC:mah] subset: gosubset_prok synonym: "NAD (reduced) regeneration" EXACT [] synonym: "reduced NAD regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide regeneration" EXACT [] is_a: GO:0006734 ! NADH metabolic process [Term] id: GO:0006738 name: nicotinamide riboside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide riboside, the product of the formation of a glycosidic bond between ribose and nicotinamide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "N-ribosylnicotinamide catabolic process" EXACT [ChEBI:15927] synonym: "nicotinamide riboside breakdown" EXACT [] synonym: "nicotinamide riboside catabolism" EXACT [] synonym: "nicotinamide riboside degradation" EXACT [] is_a: GO:0046495 ! nicotinamide riboside metabolic process is_a: GO:0070638 ! pyridine nucleoside catabolic process [Term] id: GO:0006739 name: NADP metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; metabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NAD phosphorylation and dephosphorylation" RELATED [] synonym: "NADP (oxidized) metabolic process" EXACT [] synonym: "NADP (oxidized) metabolism" EXACT [] synonym: "NADP (reduced) metabolic process" EXACT [] synonym: "NADP (reduced) metabolism" EXACT [] synonym: "NADP metabolism" EXACT [] synonym: "NADPH metabolic process" EXACT [] synonym: "NADPH metabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "oxidized NADP metabolic process" EXACT [] synonym: "oxidized NADP metabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] synonym: "reduced NADP metabolic process" EXACT [] synonym: "reduced NADP metabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate metabolism" EXACT [] is_a: GO:0046496 ! nicotinamide nucleotide metabolic process [Term] id: GO:0006740 name: NADPH regeneration namespace: biological_process def: "A metabolic process by which a pool of NADPH generated by the reduction of NADP+." [GOC:mah] subset: gosubset_prok synonym: "NADP (reduced) regeneration" EXACT [] synonym: "reduced NADP regeneration" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate regeneration" EXACT [] xref: Reactome:389542 "NADPH regeneration" xref: Reactome:563260 "NADPH regeneration" xref: Reactome:588869 "NADPH regeneration" xref: Reactome:609579 "NADPH regeneration" xref: Reactome:634293 "NADPH regeneration" xref: Reactome:645761 "NADPH regeneration" xref: Reactome:656090 "NADPH regeneration" xref: Reactome:661262 "NADPH regeneration" xref: Reactome:667036 "NADPH regeneration" xref: Reactome:673183 "NADPH regeneration" xref: Reactome:678874 "NADPH regeneration" xref: Reactome:683805 "NADPH regeneration" xref: Reactome:690029 "NADPH regeneration" xref: Reactome:701802 "NADPH regeneration" xref: Reactome:716377 "NADPH regeneration" xref: Reactome:728313 "NADPH regeneration" xref: Reactome:731133 "NADPH regeneration" xref: Reactome:738578 "NADPH regeneration" is_a: GO:0006739 ! NADP metabolic process [Term] id: GO:0006741 name: NADP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; biosynthesis may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NADP (oxidized) biosynthesis" EXACT [] synonym: "NADP (oxidized) biosynthetic process" EXACT [] synonym: "NADP (reduced) biosynthesis" EXACT [] synonym: "NADP (reduced) biosynthetic process" EXACT [] synonym: "NADP anabolism" EXACT [] synonym: "NADP biosynthesis" EXACT [] synonym: "NADP formation" EXACT [] synonym: "NADP synthesis" EXACT [] synonym: "NADPH biosynthesis" EXACT [] synonym: "NADPH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "oxidized NADP biosynthesis" EXACT [] synonym: "oxidized NADP biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] synonym: "reduced NADP biosynthesis" EXACT [] synonym: "reduced NADP biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate biosynthetic process" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process [Term] id: GO:0006742 name: NADP catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; catabolism may be of either the oxidized form, NADP, or the reduced form, NADPH." [GOC:mah] subset: gosubset_prok synonym: "NADP (oxidized) catabolic process" EXACT [] synonym: "NADP (oxidized) catabolism" EXACT [] synonym: "NADP (reduced) catabolic process" EXACT [] synonym: "NADP (reduced) catabolism" EXACT [] synonym: "NADP breakdown" EXACT [] synonym: "NADP catabolism" EXACT [] synonym: "NADP degradation" EXACT [] synonym: "NADPH catabolic process" EXACT [] synonym: "NADPH catabolism" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "oxidized NADP catabolic process" EXACT [] synonym: "oxidized NADP catabolism" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] synonym: "reduced NADP catabolic process" EXACT [] synonym: "reduced NADP catabolism" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide phosphate catabolism" EXACT [] is_a: GO:0006739 ! NADP metabolic process is_a: GO:0019364 ! pyridine nucleotide catabolic process [Term] id: GO:0006743 name: ubiquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] subset: gosubset_prok synonym: "coenzyme Q metabolic process" EXACT [] synonym: "coenzyme Q metabolism" EXACT [] synonym: "coenzyme Q6 metabolic process" NARROW [] synonym: "coenzyme Q6 metabolism" NARROW [] synonym: "ubiquinone metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0042180 ! cellular ketone metabolic process is_a: GO:0042375 ! quinone cofactor metabolic process [Term] id: GO:0006744 name: ubiquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme." [GOC:mah] subset: gosubset_prok synonym: "coenzyme Q biosynthesis" EXACT [] synonym: "coenzyme Q biosynthetic process" EXACT [] synonym: "coenzyme Q10 biosynthesis" NARROW [] synonym: "coenzyme Q10 biosynthetic process" NARROW [] synonym: "coenzyme Q6 biosynthesis" NARROW [] synonym: "coenzyme Q6 biosynthetic process" NARROW [] synonym: "coenzyme Q8 biosynthesis" NARROW [] synonym: "coenzyme Q8 biosynthetic process" NARROW [] synonym: "coenzyme Q9 biosynthesis" NARROW [] synonym: "coenzyme Q9 biosynthetic process" NARROW [] synonym: "ubiquinone anabolism" EXACT [] synonym: "ubiquinone biosynthesis" EXACT [] synonym: "ubiquinone formation" EXACT [] synonym: "ubiquinone synthesis" EXACT [] xref: MetaCyc:UBISYN-PWY is_a: GO:0006743 ! ubiquinone metabolic process is_a: GO:0045426 ! quinone cofactor biosynthetic process [Term] id: GO:0006746 name: FADH2 metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the reduced form of flavin-adenine dinucleotide." [GOC:ai] subset: gosubset_prok synonym: "FADH2 metabolism" EXACT [] is_a: GO:0006733 ! oxidoreduction coenzyme metabolic process is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0006747 name: FAD biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "FAD anabolism" EXACT [] synonym: "FAD biosynthesis" EXACT [] synonym: "FAD formation" EXACT [] synonym: "FAD synthesis" EXACT [] synonym: "flavin adenine dinucleotide biosynthesis" EXACT [] synonym: "flavin adenine dinucleotide biosynthetic process" EXACT [] synonym: "flavin-adenine dinucleotide biosynthesis" EXACT [] synonym: "flavin-adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0006746 ! FADH2 metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0042727 ! riboflavin and derivative biosynthetic process is_a: GO:0046443 ! FAD metabolic process [Term] id: GO:0006748 name: lipoamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoamide, the functional form of lipoic acid in which the carboxyl group is attached to protein by an amide linkage to a lysine amino group." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "lipoamide metabolism" EXACT [] is_a: GO:0000273 ! lipoic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006749 name: glutathione metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins; it has a specific role in the reduction of hydrogen peroxide (H2O2) and oxidized ascorbate, and it participates in the gamma-glutamyl cycle." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione metabolism" EXACT [] synonym: "oxidized glutathione reduction" NARROW [] is_a: GO:0006518 ! peptide metabolic process is_a: GO:0006575 ! cellular amino acid derivative metabolic process is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0006790 ! sulfur metabolic process [Term] id: GO:0006750 name: glutathione biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione anabolism" EXACT [] synonym: "glutathione biosynthesis" EXACT [] synonym: "glutathione formation" EXACT [] synonym: "glutathione synthesis" EXACT [] xref: MetaCyc:GLUTATHIONESYN-PWY xref: Reactome:174403 "Glutathione synthesis" xref: Reactome:563211 "Glutathione synthesis" xref: Reactome:588816 "Glutathione synthesis" xref: Reactome:609540 "Glutathione synthesis" xref: Reactome:634247 "Glutathione synthesis" xref: Reactome:645730 "Glutathione synthesis" xref: Reactome:656057 "Glutathione synthesis" xref: Reactome:661237 "Glutathione synthesis" xref: Reactome:667007 "Glutathione synthesis" xref: Reactome:673153 "Glutathione synthesis" xref: Reactome:678852 "Glutathione synthesis" xref: Reactome:683782 "Glutathione synthesis" xref: Reactome:690008 "Glutathione synthesis" xref: Reactome:701777 "Glutathione synthesis" xref: Reactome:716351 "Glutathione synthesis" xref: Reactome:728291 "Glutathione synthesis" xref: Reactome:731117 "Glutathione synthesis" is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process is_a: GO:0043043 ! peptide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0006751 name: glutathione catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glutathione, the tripeptide glutamylcysteinylglycine, which acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins." [GOC:ai, http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glutathione breakdown" EXACT [] synonym: "glutathione catabolism" EXACT [] synonym: "glutathione degradation" EXACT [] is_a: GO:0006749 ! glutathione metabolic process is_a: GO:0009109 ! coenzyme catabolic process is_a: GO:0042219 ! cellular amino acid derivative catabolic process is_a: GO:0043171 ! peptide catabolic process is_a: GO:0044273 ! sulfur compound catabolic process [Term] id: GO:0006752 name: group transfer coenzyme metabolic process namespace: biological_process subset: gosubset_prok synonym: "group transfer coenzyme metabolism" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process [Term] id: GO:0006753 name: nucleoside phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any phosphorylated nucleoside." [GOC:mah] subset: gosubset_prok synonym: "nucleoside phosphate metabolism" EXACT [] is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0006754 name: ATP biosynthetic process namespace: biological_process alt_id: GO:0006758 def: "The chemical reactions and pathways resulting in the formation of ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ATP anabolism" EXACT [] synonym: "ATP biosynthesis" EXACT [] synonym: "ATP formation" EXACT [] synonym: "ATP synthesis" EXACT [] xref: Reactome:164832 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:164840 "ADP and Pi bind to ATPase" xref: Reactome:541036 "ADP and Pi bind to ATPase" xref: Reactome:543249 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:567825 "ADP and Pi bind to ATPase" xref: Reactome:570361 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:592734 "ADP and Pi bind to ATPase" xref: Reactome:594642 "ATP is synthesized from ADP and Pi by ATPase" xref: Reactome:614647 "ADP and Pi bind to ATPase" xref: Reactome:617074 "ATP is synthesized from ADP and Pi by ATPase" is_a: GO:0009206 ! purine ribonucleoside triphosphate biosynthetic process is_a: GO:0046034 ! ATP metabolic process [Term] id: GO:0006755 name: carbamoyl phosphate-ADP transphosphorylation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because, according to PUMA2, this "pathway" is a single reaction, corresponding to 'carbamate kinase activity ; GO:0008804' (EC:2.7.2.2). is_obsolete: true [Term] id: GO:0006756 name: AMP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into AMP, adenosine monophosphate, to produce ADP. Addition of two phosphate groups produces ATP." [GOC:ai] subset: gosubset_prok is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046033 ! AMP metabolic process is_a: GO:0046940 ! nucleoside monophosphate phosphorylation [Term] id: GO:0006757 name: ADP phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into ADP, adenosine diphosphate, to produce ATP." [GOC:ai] subset: gosubset_prok is_a: GO:0006165 ! nucleoside diphosphate phosphorylation is_a: GO:0006754 ! ATP biosynthetic process is_a: GO:0046031 ! ADP metabolic process [Term] id: GO:0006759 name: ATP regeneration namespace: biological_process subset: gosubset_prok is_a: GO:0006754 ! ATP biosynthetic process [Term] id: GO:0006760 name: folic acid and derivative metabolic process namespace: biological_process def: "The chemical reactions and pathways involving folic acid and its derivatives." [GOC:ai] subset: gosubset_prok synonym: "folate and derivative metabolic process" EXACT [] synonym: "folate and derivative metabolism" EXACT [] synonym: "folic acid and derivative metabolism" EXACT [] synonym: "vitamin B9 and derivative metabolic process" EXACT [] synonym: "vitamin B9 and derivative metabolism" EXACT [] synonym: "vitamin M and derivative metabolic process" EXACT [] synonym: "vitamin M and derivative metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0006752 ! group transfer coenzyme metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0006761 name: dihydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate." [GOC:ai] subset: gosubset_prok synonym: "7,8-dihydrofolate biosynthesis" EXACT [] synonym: "7,8-dihydrofolate biosynthetic process" EXACT [] synonym: "dihydrofolate anabolism" EXACT [] synonym: "dihydrofolate biosynthesis" EXACT [] synonym: "dihydrofolate formation" EXACT [] synonym: "dihydrofolate synthesis" EXACT [] is_a: GO:0009396 ! folic acid and derivative biosynthetic process is_a: GO:0042559 ! pteridine and derivative biosynthetic process is_a: GO:0046452 ! dihydrofolate metabolic process [Term] id: GO:0006762 name: dihydrofolate reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0004146 consider: GO:0046452 [Term] id: GO:0006766 name: vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving vitamins. Vitamin is a general term for a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body. Vitamins may be water-soluble or fat-soluble and usually serve as components of coenzyme systems." [GOC:ai] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "vitamin metabolism" EXACT [] xref: Reactome:196854 "Metabolism of vitamins and cofactors" xref: Reactome:562567 "Metabolism of vitamins and cofactors" xref: Reactome:588193 "Metabolism of vitamins and cofactors" xref: Reactome:608961 "Metabolism of vitamins and cofactors" xref: Reactome:633643 "Metabolism of vitamins and cofactors" xref: Reactome:645271 "Metabolism of vitamins and cofactors" xref: Reactome:655650 "Metabolism of vitamins and cofactors" xref: Reactome:660925 "Metabolism of vitamins and cofactors" xref: Reactome:666700 "Metabolism of vitamins and cofactors" xref: Reactome:672796 "Metabolism of vitamins and cofactors" xref: Reactome:678519 "Metabolism of vitamins and cofactors" xref: Reactome:683476 "Metabolism of vitamins and cofactors" xref: Reactome:689680 "Metabolism of vitamins and cofactors" xref: Reactome:701416 "Metabolism of vitamins and cofactors" xref: Reactome:715987 "Metabolism of vitamins and cofactors" xref: Reactome:720704 "Metabolism of vitamins and cofactors" xref: Reactome:727934 "Metabolism of vitamins and cofactors" xref: Reactome:730915 "Metabolism of vitamins and cofactors" xref: Reactome:733012 "Metabolism of vitamins and cofactors" xref: Reactome:733850 "Metabolism of vitamins and cofactors" xref: Reactome:735546 "Metabolism of vitamins and cofactors" xref: Reactome:736530 "Metabolism of vitamins and cofactors" xref: Reactome:738456 "Metabolism of vitamins and cofactors" is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0006767 name: water-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of a diverse group of vitamins that are soluble in water." [GOC:jl] subset: gosubset_prok synonym: "water-soluble vitamin metabolism" EXACT [] xref: Reactome:196849 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:562566 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:588192 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:608960 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:633642 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:645270 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:655649 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:660924 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:666699 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:672795 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:678518 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:683475 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:689679 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:701415 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:715986 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:720703 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:727933 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:730914 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:733011 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:733849 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:735545 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:736529 "Metabolism of water-soluble vitamins and cofactors" xref: Reactome:738455 "Metabolism of water-soluble vitamins and cofactors" is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006768 name: biotin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid; the (+) enantiomer is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biotin metabolism" EXACT [] synonym: "vitamin B7 metabolic process" EXACT [] synonym: "vitamin B7 metabolism" EXACT [] synonym: "vitamin H metabolic process" EXACT [] synonym: "vitamin H metabolism" EXACT [] xref: Reactome:196780 "Biotin metabolism" xref: Reactome:562999 "Biotin metabolism" xref: Reactome:588616 "Biotin metabolism" xref: Reactome:609357 "Biotin metabolism" xref: Reactome:634050 "Biotin metabolism" xref: Reactome:645582 "Biotin metabolism" xref: Reactome:655910 "Biotin metabolism" xref: Wikipedia:Biotin is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006790 ! sulfur metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043603 ! cellular amide metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006769 name: nicotinamide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving nicotinamide, pyridine-3-carboxamide, the amide of nicotinic acid. It is a member of the B complex of vitamins and occurs widely in living organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "niacin metabolic process" RELATED [] synonym: "niacin metabolism" RELATED [] synonym: "nicotinamide metabolism" EXACT [] synonym: "vitamin B3 metabolic process" BROAD [] synonym: "vitamin B3 metabolism" BROAD [] xref: MetaCyc:PWY-5083 xref: Reactome:197264 "Nicotinamide salvaging" xref: Reactome:562641 "Nicotinamide salvaging" xref: Reactome:588266 "Nicotinamide salvaging" xref: Reactome:609019 "Nicotinamide salvaging" xref: Reactome:633710 "Nicotinamide salvaging" xref: Reactome:645323 "Nicotinamide salvaging" xref: Reactome:655697 "Nicotinamide salvaging" xref: Reactome:683529 "Nicotinamide salvaging" xref: Reactome:689731 "Nicotinamide salvaging" xref: Reactome:701462 "Nicotinamide salvaging" xref: Reactome:716033 "Nicotinamide salvaging" xref: Reactome:727983 "Nicotinamide salvaging" xref: Reactome:730917 "Nicotinamide salvaging" xref: Reactome:733022 "Nicotinamide salvaging" xref: Reactome:735647 "Nicotinamide salvaging" xref: Reactome:738491 "Nicotinamide salvaging" is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0019362 ! pyridine nucleotide metabolic process is_a: GO:0043603 ! cellular amide metabolic process [Term] id: GO:0006771 name: riboflavin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin metabolism" EXACT [] synonym: "vitamin B2 metabolic process" EXACT [] synonym: "vitamin B2 metabolism" EXACT [] synonym: "vitamin G metabolic process" EXACT [] synonym: "vitamin G metabolism" EXACT [] xref: Wikipedia:Riboflavin is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0042726 ! riboflavin and derivative metabolic process [Term] id: GO:0006772 name: thiamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin metabolism" EXACT [] synonym: "thiamine metabolic process" EXACT [] synonym: "thiamine metabolism" EXACT [] synonym: "vitamin B1 metabolic process" EXACT [] synonym: "vitamin B1 metabolism" EXACT [] xref: Wikipedia:Thiamine is_a: GO:0042723 ! thiamin and derivative metabolic process [Term] id: GO:0006774 name: vitamin B12 reduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function rather than a biological process. is_obsolete: true consider: GO:0009235 consider: GO:0050453 [Term] id: GO:0006775 name: fat-soluble vitamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of any of a diverse group of vitamins that are soluble in organic solvents and relatively insoluble in water." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "fat-soluble vitamin metabolism" EXACT [] is_a: GO:0006766 ! vitamin metabolic process [Term] id: GO:0006776 name: vitamin A metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the vitamin A compounds, retinol, retinal (retinaldehyde) and retinoic acid, all of which are derivatives of beta-carotene." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "vitamin A metabolism" EXACT [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0006775 ! fat-soluble vitamin metabolic process [Term] id: GO:0006777 name: Mo-molybdopterin cofactor biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands." [http://www.sunysb.edu/biochem/BIOCHEM/facultypages/schindelin/, ISSN:09498257] subset: gosubset_prok synonym: "Mo-molybdopterin cofactor anabolism" EXACT [] synonym: "Mo-molybdopterin cofactor biosynthesis" EXACT [] synonym: "Mo-molybdopterin cofactor formation" EXACT [] synonym: "Mo-molybdopterin cofactor synthesis" EXACT [] synonym: "Moco biosynthesis" EXACT [] synonym: "Moco biosynthetic process" EXACT [] synonym: "molybdenum cofactor biosynthetic process" RELATED [] xref: MetaCyc:PWY-5354 is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0019720 ! Mo-molybdopterin cofactor metabolic process is_a: GO:0032324 ! molybdopterin cofactor biosynthetic process [Term] id: GO:0006778 name: porphyrin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any member of a large group of derivatives or analogs of porphyrin. Porphyrins consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin metabolism" EXACT [] xref: Reactome:189445 "Metabolism of porphyrins" xref: Reactome:562850 "Metabolism of porphyrins" xref: Reactome:588470 "Metabolism of porphyrins" xref: Reactome:609211 "Metabolism of porphyrins" xref: Reactome:633904 "Metabolism of porphyrins" xref: Reactome:645481 "Metabolism of porphyrins" xref: Reactome:656205 "Metabolism of porphyrins" xref: Reactome:661039 "Metabolism of porphyrins" xref: Reactome:666816 "Metabolism of porphyrins" xref: Reactome:672927 "Metabolism of porphyrins" xref: Reactome:678640 "Metabolism of porphyrins" xref: Reactome:683573 "Metabolism of porphyrins" xref: Reactome:689809 "Metabolism of porphyrins" xref: Reactome:701524 "Metabolism of porphyrins" xref: Reactome:716108 "Metabolism of porphyrins" xref: Reactome:728072 "Metabolism of porphyrins" xref: Reactome:730974 "Metabolism of porphyrins" xref: Reactome:733040 "Metabolism of porphyrins" xref: Reactome:733884 "Metabolism of porphyrins" xref: Reactome:735603 "Metabolism of porphyrins" xref: Reactome:736555 "Metabolism of porphyrins" xref: Reactome:738515 "Metabolism of porphyrins" xref: Wikipedia:Porphyrin is_a: GO:0033013 ! tetrapyrrole metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0006779 name: porphyrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin anabolism" EXACT [] synonym: "porphyrin biosynthesis" EXACT [] synonym: "porphyrin formation" EXACT [] synonym: "porphyrin synthesis" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0006780 name: uroporphyrinogen III biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of uroporphyrinogen III." [GOC:ai] subset: gosubset_prok synonym: "uroporphyrinogen III anabolism" EXACT [] synonym: "uroporphyrinogen III biosynthesis" EXACT [] synonym: "uroporphyrinogen III formation" EXACT [] synonym: "uroporphyrinogen III synthesis" EXACT [] is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046502 ! uroporphyrinogen III metabolic process relationship: part_of GO:0006779 ! porphyrin biosynthetic process [Term] id: GO:0006781 name: succinyl-CoA pathway namespace: biological_process def: "The chemical reactions that utilize succinyl-CoA in the synthesis of protoporphyrin IX." [GOC:isa_complete, ISBN:0879010479] subset: gosubset_prok synonym: "biosynthesis of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthesis of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl CoA" EXACT [] synonym: "biosynthetic process of protoporphyrin IX via succinyl-CoA" EXACT [] synonym: "succinyl CoA pathway" EXACT [] is_a: GO:0006104 ! succinyl-CoA metabolic process is_a: GO:0006779 ! porphyrin biosynthetic process relationship: part_of GO:0006780 ! uroporphyrinogen III biosynthetic process [Term] id: GO:0006782 name: protoporphyrinogen IX biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of protoporphyrinogen IX." [GOC:go_curators] subset: gosubset_prok synonym: "protoporphyrinogen IX anabolism" EXACT [] synonym: "protoporphyrinogen IX biosynthesis" EXACT [] synonym: "protoporphyrinogen IX formation" EXACT [] synonym: "protoporphyrinogen IX synthesis" EXACT [] is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0046501 ! protoporphyrinogen IX metabolic process relationship: part_of GO:0006783 ! heme biosynthetic process [Term] id: GO:0006783 name: heme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors." [GOC:jl] subset: gosubset_prok synonym: "haem biosynthesis" EXACT [] synonym: "haem biosynthetic process" EXACT [] synonym: "heme anabolism" EXACT [] synonym: "heme biosynthesis" EXACT [] synonym: "heme formation" EXACT [] synonym: "heme synthesis" EXACT [] xref: MetaCyc:HEMESYN2-PWY xref: Reactome:189451 "Heme biosynthesis" xref: Reactome:562849 "Heme biosynthesis" xref: Reactome:588469 "Heme biosynthesis" xref: Reactome:609210 "Heme biosynthesis" xref: Reactome:633903 "Heme biosynthesis" xref: Reactome:645480 "Heme biosynthesis" xref: Reactome:656204 "Heme biosynthesis" xref: Reactome:661038 "Heme biosynthesis" xref: Reactome:666815 "Heme biosynthesis" xref: Reactome:672926 "Heme biosynthesis" xref: Reactome:678639 "Heme biosynthesis" xref: Reactome:683572 "Heme biosynthesis" xref: Reactome:689808 "Heme biosynthesis" xref: Reactome:701523 "Heme biosynthesis" xref: Reactome:716107 "Heme biosynthesis" xref: Reactome:728071 "Heme biosynthesis" xref: Reactome:730973 "Heme biosynthesis" xref: Reactome:733039 "Heme biosynthesis" xref: Reactome:733883 "Heme biosynthesis" xref: Reactome:735602 "Heme biosynthesis" xref: Reactome:736554 "Heme biosynthesis" xref: Reactome:738514 "Heme biosynthesis" is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0042168 ! heme metabolic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0006784 name: heme a biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme a, a derivative of heme found in cytochrome aa3." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "haem a biosynthesis" EXACT [] synonym: "haem a biosynthetic process" EXACT [] synonym: "heme a anabolism" EXACT [] synonym: "heme a biosynthesis" EXACT [] synonym: "heme a formation" EXACT [] synonym: "heme a synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046160 ! heme a metabolic process [Term] id: GO:0006785 name: heme b biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme b, a Fe(II) porphyrin complex readily isolated from the hemoglobin of beef blood, but also found in other proteins including other hemoglobins, myoglobins, cytochromes P-450, catalases, peroxidases as well as b type cytochromes." [http://www.chem.qmul.ac.uk/iupac/bioinorg/PR.html#25] subset: gosubset_prok synonym: "haem b biosynthesis" EXACT [] synonym: "haem b biosynthetic process" EXACT [] synonym: "heme b anabolism" EXACT [] synonym: "heme b biosynthesis" EXACT [] synonym: "heme b formation" EXACT [] synonym: "heme b synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046492 ! heme b metabolic process [Term] id: GO:0006786 name: heme c biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of heme c, a derivative of heme found in cytochromes c, b4, and f." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "haem c biosynthesis" EXACT [] synonym: "haem c biosynthetic process" EXACT [] synonym: "heme c anabolism" EXACT [] synonym: "heme c biosynthesis" EXACT [] synonym: "heme c formation" EXACT [] synonym: "heme c synthesis" EXACT [] is_a: GO:0006783 ! heme biosynthetic process is_a: GO:0046162 ! heme c metabolic process [Term] id: GO:0006787 name: porphyrin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any member of a large group of derivatives or analogs of porphyrin. Porphyrin consists of a ring of four pyrrole nuclei linked each to the next at their alpha positions through a methine group." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "porphyrin breakdown" EXACT [] synonym: "porphyrin catabolism" EXACT [] synonym: "porphyrin degradation" EXACT [] is_a: GO:0006778 ! porphyrin metabolic process is_a: GO:0033015 ! tetrapyrrole catabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0006788 name: heme oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the loss of electrons from one or more atoms in heme." [GOC:mah] subset: gosubset_prok synonym: "haem oxidation" EXACT [] is_a: GO:0042168 ! heme metabolic process relationship: part_of GO:0006787 ! porphyrin catabolic process [Term] id: GO:0006789 name: bilirubin conjugation namespace: biological_process subset: gosubset_prok is_a: GO:0006787 ! porphyrin catabolic process [Term] id: GO:0006790 name: sulfur metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione." [GOC:ai] subset: gosubset_prok synonym: "sulfur metabolism" EXACT [] synonym: "sulphur metabolic process" EXACT [] synonym: "sulphur metabolism" EXACT [] xref: Wikipedia:Sulfur_metabolism is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006791 name: sulfur utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sulfur sources and then activates genes to scavenge the last traces of the primary sulfur source and to transport and metabolize alternate sulfur sources. The utilization process begins when the cell or organism detects sulfur levels, includes the activation of genes whose products detect, transport or metabolize sulfur-containing compounds, and ends when the sulfur is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: gosubset_prok synonym: "sulphur utilization" EXACT [] is_a: GO:0008150 ! biological_process relationship: has_part GO:0006790 ! sulfur metabolic process [Term] id: GO:0006792 name: regulation of sulfur utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sulfur utilization." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of sulphur utilization" EXACT [] is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006791 ! sulfur utilization relationship: regulates GO:0006791 ! sulfur utilization [Term] id: GO:0006793 name: phosphorus metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the nonmetallic element phosphorus or compounds that contain phosphorus, usually in the form of a phosphate group (PO4)." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "phosphorus metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006794 name: phosphorus utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary phosphorus source and then activates genes to scavenge the last traces of the primary phosphorus source and to transport and metabolize alternative phosphorus sources. The utilization process begins when the cell or organism detects phosphorus levels, includes the phosphorus-containing substances, and ends when phosphorus is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] subset: gosubset_prok is_a: GO:0008150 ! biological_process relationship: has_part GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006795 name: regulation of phosphorus utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phosphorus utilization." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006794 ! phosphorus utilization relationship: regulates GO:0006794 ! phosphorus utilization [Term] id: GO:0006796 name: phosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid." [GOC:ai] subset: goslim_pombe subset: gosubset_prok synonym: "phosphate metabolism" EXACT [] is_a: GO:0006793 ! phosphorus metabolic process [Term] id: GO:0006797 name: polyphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate metabolism" EXACT [] is_a: GO:0006796 ! phosphate metabolic process [Term] id: GO:0006798 name: polyphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a polyphosphate, the anion or salt of polyphosphoric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate breakdown" EXACT [] synonym: "polyphosphate catabolism" EXACT [] synonym: "polyphosphate degradation" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0006799 name: polyphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "polyphosphate anabolism" EXACT [] synonym: "polyphosphate biosynthesis" EXACT [] synonym: "polyphosphate formation" EXACT [] synonym: "polyphosphate synthesis" EXACT [] is_a: GO:0006797 ! polyphosphate metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0006800 name: oxygen and reactive oxygen species metabolic process namespace: biological_process def: "The chemical reactions and pathways involving dioxygen (O2), or any of the reactive oxygen species, e.g. superoxide anions (O2-), hydrogen peroxide (H2O2), and hydroxyl radicals (-OH)." [GOC:jl, PMID:12115731] subset: goslim_pir subset: gosubset_prok synonym: "oxygen and active oxygen species metabolism" EXACT [] synonym: "oxygen and AOS metabolism" EXACT [] synonym: "oxygen and reactive oxidative species metabolism" EXACT [] synonym: "oxygen and reactive oxygen intermediate metabolism" EXACT [] synonym: "oxygen and reactive oxygen species metabolism" EXACT [] synonym: "oxygen and ROI metabolism" EXACT [] synonym: "oxygen and ROS metabolic process" EXACT [] synonym: "oxygen and ROS metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0006801 name: superoxide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "oxygen free radical metabolic process" EXACT [] synonym: "oxygen free radical metabolism" EXACT [] synonym: "superoxide free radical metabolic process" EXACT [] synonym: "superoxide free radical metabolism" EXACT [] synonym: "superoxide metabolism" EXACT [] is_a: GO:0006800 ! oxygen and reactive oxygen species metabolic process [Term] id: GO:0006802 name: catalase reaction namespace: biological_process def: "OBSOLETE. The processes involved in the induction or activation of catalase, an enzyme that catalyzes the conversion of H2O2 into H2O." [GOC:jl, PMID:11245904] comment: This term was made obsolete because it represents a molecular function. synonym: "hydroperoxidase reaction" RELATED [] is_obsolete: true consider: GO:0004096 [Term] id: GO:0006803 name: glutathione conjugation reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0004364 [Term] id: GO:0006804 name: peroxidase reaction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0004601 [Term] id: GO:0006805 name: xenobiotic metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to living organisms. Used of chemical compounds, e.g. a xenobiotic chemical, such as a pesticide." [GOC:cab2] subset: goslim_pir subset: gosubset_prok synonym: "xenobiotic metabolism" EXACT [] xref: Reactome:140191 "Phase 1 functionalization" xref: Reactome:156580 "Phase II conjugation" xref: Reactome:156587 "Amino Acid conjugation" xref: Reactome:159424 "Conjugation of carboxylic acids" xref: Reactome:177128 "Conjugation of salicylate with glycine" xref: Reactome:177135 "Conjugation of benzoate with glycine" xref: Reactome:177162 "Conjugation of phenylacetate with glutamine" xref: Reactome:211859 "Biological oxidations" xref: Reactome:211945 "Phase 1 - Functionalization of compounds" xref: Reactome:562570 "Phase 1 - Functionalization of compounds" xref: Reactome:562571 "Biological oxidations" xref: Reactome:562602 "Phase II conjugation" xref: Reactome:562653 "Phase 1 functionalization" xref: Reactome:562966 "Conjugation of benzoate with glycine" xref: Reactome:562967 "Conjugation of carboxylic acids" xref: Reactome:562968 "Amino Acid conjugation" xref: Reactome:563326 "Conjugation of phenylacetate with glutamine" xref: Reactome:563376 "Conjugation of salicylate with glycine" xref: Reactome:588196 "Phase 1 - Functionalization of compounds" xref: Reactome:588197 "Biological oxidations" xref: Reactome:588228 "Phase II conjugation" xref: Reactome:588278 "Phase 1 functionalization" xref: Reactome:588582 "Conjugation of benzoate with glycine" xref: Reactome:588583 "Conjugation of carboxylic acids" xref: Reactome:588584 "Amino Acid conjugation" xref: Reactome:588941 "Conjugation of phenylacetate with glutamine" xref: Reactome:588997 "Conjugation of salicylate with glycine" xref: Reactome:608986 "Phase 1 - Functionalization of compounds" xref: Reactome:608987 "Biological oxidations" xref: Reactome:608991 "Phase II conjugation" xref: Reactome:609201 "Phase 1 functionalization" xref: Reactome:609323 "Conjugation of benzoate with glycine" xref: Reactome:609324 "Conjugation of carboxylic acids" xref: Reactome:609325 "Amino Acid conjugation" xref: Reactome:609664 "Conjugation of phenylacetate with glutamine" xref: Reactome:609717 "Conjugation of salicylate with glycine" xref: Reactome:633668 "Phase 1 - Functionalization of compounds" xref: Reactome:633669 "Biological oxidations" xref: Reactome:633674 "Phase II conjugation" xref: Reactome:633894 "Phase 1 functionalization" xref: Reactome:645297 "Phase II conjugation" xref: Reactome:645298 "Biological oxidations" xref: Reactome:645333 "Phase 1 - Functionalization of compounds" xref: Reactome:645473 "Phase 1 functionalization" xref: Reactome:655673 "Phase II conjugation" xref: Reactome:655674 "Biological oxidations" xref: Reactome:655707 "Phase 1 - Functionalization of compounds" xref: Reactome:655836 "Phase 1 functionalization" xref: Reactome:660976 "Phase 1 - Functionalization of compounds" xref: Reactome:660977 "Biological oxidations" xref: Reactome:661027 "Phase 1 functionalization" xref: Reactome:661239 "Phase II conjugation" xref: Reactome:666751 "Phase 1 - Functionalization of compounds" xref: Reactome:666752 "Biological oxidations" xref: Reactome:666806 "Phase 1 functionalization" xref: Reactome:667009 "Phase II conjugation" xref: Reactome:672827 "Phase II conjugation" xref: Reactome:672828 "Biological oxidations" xref: Reactome:672839 "Phase 1 - Functionalization of compounds" xref: Reactome:672858 "Phase 1 functionalization" xref: Reactome:678550 "Phase II conjugation" xref: Reactome:678551 "Biological oxidations" xref: Reactome:678574 "Phase 1 - Functionalization of compounds" xref: Reactome:678833 "Phase 1 functionalization" xref: Reactome:683499 "Phase 1 - Functionalization of compounds" xref: Reactome:683500 "Biological oxidations" xref: Reactome:683571 "Phase 1 functionalization" xref: Reactome:683784 "Phase II conjugation" xref: Reactome:689711 "Phase II conjugation" xref: Reactome:689712 "Biological oxidations" xref: Reactome:689738 "Phase 1 - Functionalization of compounds" xref: Reactome:689801 "Phase 1 functionalization" xref: Reactome:701444 "Phase II conjugation" xref: Reactome:701445 "Biological oxidations" xref: Reactome:701469 "Phase 1 - Functionalization of compounds" xref: Reactome:701512 "Phase 1 functionalization" xref: Reactome:716015 "Phase II conjugation" xref: Reactome:716016 "Biological oxidations" xref: Reactome:716040 "Phase 1 - Functionalization of compounds" xref: Reactome:716098 "Phase 1 functionalization" xref: Reactome:720946 "Phase II conjugation" xref: Reactome:720947 "Biological oxidations" xref: Reactome:727990 "Phase 1 - Functionalization of compounds" xref: Reactome:727991 "Biological oxidations" xref: Reactome:728064 "Phase 1 functionalization" xref: Reactome:728135 "Conjugation of benzoate with glycine" xref: Reactome:728136 "Conjugation of carboxylic acids" xref: Reactome:728137 "Amino Acid conjugation" xref: Reactome:728138 "Phase II conjugation" xref: Reactome:728362 "Conjugation of phenylacetate with glutamine" xref: Reactome:728399 "Conjugation of salicylate with glycine" xref: Reactome:730923 "Phase 1 - Functionalization of compounds" xref: Reactome:730924 "Biological oxidations" xref: Reactome:731119 "Phase II conjugation" xref: Reactome:733028 "Phase 1 - Functionalization of compounds" xref: Reactome:733029 "Biological oxidations" xref: Reactome:733063 "Conjugation of benzoate with glycine" xref: Reactome:733064 "Conjugation of carboxylic acids" xref: Reactome:733065 "Amino Acid conjugation" xref: Reactome:733066 "Phase II conjugation" xref: Reactome:733132 "Conjugation of phenylacetate with glutamine" xref: Reactome:733141 "Conjugation of salicylate with glycine" xref: Reactome:733863 "Phase 1 - Functionalization of compounds" xref: Reactome:733864 "Biological oxidations" xref: Reactome:733946 "Phase II conjugation" xref: Reactome:735585 "Phase 1 - Functionalization of compounds" xref: Reactome:735586 "Biological oxidations" xref: Reactome:735668 "Phase II conjugation" xref: Reactome:736544 "Phase 1 - Functionalization of compounds" xref: Reactome:736545 "Biological oxidations" xref: Reactome:736619 "Phase II conjugation" xref: Reactome:738473 "Phase II conjugation" xref: Reactome:738474 "Biological oxidations" xref: Reactome:738498 "Phase 1 - Functionalization of compounds" xref: Reactome:738513 "Phase 1 functionalization" xref: Wikipedia:Xenobiotic_metabolism is_a: GO:0044237 ! cellular metabolic process relationship: part_of GO:0071466 ! cellular response to xenobiotic stimulus [Term] id: GO:0006806 name: insecticide resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0017085 [Term] id: GO:0006807 name: nitrogen compound metabolic process namespace: biological_process def: "The chemical reactions and pathways involving various organic and inorganic nitrogenous compounds; includes nitrogen fixation, nitrification, denitrification, assimilatory/dissimilatory nitrate reduction and the interconversion of nitrogenous organic matter and ammonium." [GOC:go_curators, GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: Note that amino acid and derivative metabolism should not be annotated here. Instead use the 'amino acid and derivative metabolism' node. subset: goslim_pir subset: gosubset_prok synonym: "nitrogen compound metabolism" EXACT [] is_a: GO:0008152 ! metabolic process [Term] id: GO:0006808 name: regulation of nitrogen utilization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of nitrogen utilization." [GOC:go_curators] subset: gosubset_prok is_a: GO:0050789 ! regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019740 ! nitrogen utilization relationship: regulates GO:0019740 ! nitrogen utilization [Term] id: GO:0006809 name: nitric oxide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nitric oxide, nitrogen monoxide (NO), a colorless gas only slightly soluble in water." [GOC:ai] subset: gosubset_prok synonym: "nitric oxide anabolism" EXACT [] synonym: "nitric oxide biosynthesis" EXACT [] synonym: "nitric oxide formation" EXACT [] synonym: "nitric oxide synthesis" EXACT [] is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046209 ! nitric oxide metabolic process [Term] id: GO:0006810 name: transport namespace: biological_process alt_id: GO:0015457 alt_id: GO:0015460 def: "The directed movement of substances (such as macromolecules, small molecules, ions) into, out of, within or between cells, or within a multicellular organism by means of some external agent such as a transporter or pore." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "auxiliary transport protein activity" RELATED [GOC:mah] synonym: "small molecule transport" NARROW [] synonym: "solute:solute exchange" NARROW [] synonym: "transport accessory protein activity" RELATED [GOC:mah] is_a: GO:0051234 ! establishment of localization [Term] id: GO:0006811 name: ion transport namespace: biological_process def: "The directed movement of charged atoms or small charged molecules into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: goslim_generic subset: goslim_pir subset: gosubset_prok xref: Reactome:425393 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:563038 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:588657 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:609386 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:634091 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:645615 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:655941 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:661129 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:666914 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:673036 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:678756 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:683675 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:689885 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:701650 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:716230 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:720864 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:728337 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:731193 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:733144 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:733949 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:735654 "Transport of inorganic cations/anions and amino acids/oligopeptides" xref: Reactome:738570 "Transport of inorganic cations/anions and amino acids/oligopeptides" is_a: GO:0006810 ! transport [Term] id: GO:0006812 name: cation transport namespace: biological_process alt_id: GO:0006819 def: "The directed movement of cations, atoms or small molecules with a net positive charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006811 ! ion transport [Term] id: GO:0006813 name: potassium ion transport namespace: biological_process alt_id: GO:0015458 def: "The directed movement of potassium ions (K+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "K+ conductance" EXACT [] synonym: "low voltage-dependent potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "low voltage-gated potassium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "potassium conductance" NARROW [] synonym: "potassium ion conductance" NARROW [] synonym: "potassium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006814 name: sodium ion transport namespace: biological_process alt_id: GO:0006834 alt_id: GO:0016974 def: "The directed movement of sodium ions (Na+) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium channel auxiliary protein activity" RELATED [GOC:mah] synonym: "sodium transport" EXACT [] synonym: "sodium/potassium transport" BROAD [] synonym: "sodium:calcium exchange" NARROW [] synonym: "sodium:solute transport" NARROW [] is_a: GO:0015672 ! monovalent inorganic cation transport is_a: GO:0030001 ! metal ion transport [Term] id: GO:0006815 name: sodium/potassium transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. is_obsolete: true consider: GO:0006813 consider: GO:0006814 [Term] id: GO:0006816 name: calcium ion transport namespace: biological_process def: "The directed movement of calcium (Ca) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "calcium transport" EXACT [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] synonym: "sodium:calcium exchange" NARROW [] is_a: GO:0070838 ! divalent metal ion transport [Term] id: GO:0006817 name: phosphate transport namespace: biological_process def: "The directed movement of phosphate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006818 name: hydrogen transport namespace: biological_process def: "The directed movement of hydrogen (H2 or H+), into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0006820 name: anion transport namespace: biological_process alt_id: GO:0006822 def: "The directed movement of anions, atoms or small molecules with a net negative charge, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0006811 ! ion transport [Term] id: GO:0006821 name: chloride transport namespace: biological_process def: "The directed movement of chloride into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0006823 name: heavy metal ion transport namespace: biological_process def: "OBSOLETE. The directed movement of heavy metal ions into, out of, within or between cells. Heavy metals are those that can form a coordination bond with a protein, as opposed to an alkali or alkaline-earth metal that can only form an ionic bond; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:kd, GOC:mah] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0030001 [Term] id: GO:0006824 name: cobalt ion transport namespace: biological_process def: "The directed movement of cobalt (Co) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "cobalt transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0015674 ! di-, tri-valent inorganic cation transport [Term] id: GO:0006825 name: copper ion transport namespace: biological_process def: "The directed movement of copper (Cu) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006826 name: iron ion transport namespace: biological_process alt_id: GO:0015681 def: "The directed movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "iron transport" EXACT [] is_a: GO:0000041 ! transition metal ion transport is_a: GO:0015674 ! di-, tri-valent inorganic cation transport [Term] id: GO:0006827 name: high-affinity iron ion transport namespace: biological_process def: "The directed, high-affinity movement of iron (Fe) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] subset: gosubset_prok synonym: "high affinity iron ion transport" EXACT [] is_a: GO:0034755 ! iron ion transmembrane transport [Term] id: GO:0006828 name: manganese ion transport namespace: biological_process def: "The directed movement of manganese (Mn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006829 name: zinc ion transport namespace: biological_process def: "The directed movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "zinc transport" EXACT [GOC:mah] is_a: GO:0000041 ! transition metal ion transport [Term] id: GO:0006830 name: high-affinity zinc ion transport namespace: biological_process def: "The directed, high-affinity movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0006831 name: low-affinity zinc ion transport namespace: biological_process def: "The directed, low-affinity movement of zinc (Zn) ions into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] is_a: GO:0071577 ! zinc ion transmembrane transport [Term] id: GO:0006832 name: small molecule transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was an unnecessary grouping term. is_obsolete: true consider: GO:0006810 [Term] id: GO:0006833 name: water transport namespace: biological_process def: "The directed movement of water (H2O) into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok is_a: GO:0042044 ! fluid transport [Term] id: GO:0006835 name: dicarboxylic acid transport namespace: biological_process alt_id: GO:0006841 def: "The directed movement of dicarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sodium:dicarboxylate transport" RELATED [] is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006836 name: neurotransmitter transport namespace: biological_process def: "The directed movement of a neurotransmitter into, out of, within or between cells by means of some external agent such as a transporter or pore. Neurotransmitters are any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell." [GOC:ai] subset: goslim_pir synonym: "sodium:neurotransmitter transport" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0006837 name: serotonin transport namespace: biological_process def: "The directed movement of serotonin into, out of, within or between cells by means of some external agent such as a transporter or pore. Serotonin (5-hydroxytryptamine) is a monoamine neurotransmitter occurring in the peripheral and central nervous systems." [GOC:ai] is_a: GO:0015844 ! monoamine transport [Term] id: GO:0006838 name: allantoin/allantoate transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is a composite term that represents two individual processes. is_obsolete: true consider: GO:0015719 consider: GO:0015720 [Term] id: GO:0006839 name: mitochondrial transport namespace: biological_process def: "Transport of substances into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial alpha-ketoglutarate/malate transport" NARROW [] synonym: "mitochondrial aspartate/glutamate transport" NARROW [] synonym: "mitochondrial sodium/calcium ion exchange" NARROW [] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0006840 name: mitochondrial alpha-ketoglutarate/malate transport namespace: biological_process def: "OBSOLETE. The directed movement of alpha-ketoglutarate and malate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. synonym: "mitochondrial oxoglutarate/malate transport" EXACT [] is_obsolete: true replaced_by: GO:0006839 replaced_by: GO:0015367 replaced_by: GO:0015742 replaced_by: GO:0015743 [Term] id: GO:0006842 name: tricarboxylic acid transport namespace: biological_process def: "The directed movement of tricarboxylic acids into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006843 name: mitochondrial citrate transport namespace: biological_process def: "The directed movement of citrate, 2-hydroxy-1,2,3-propanetricarboyxlate, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015746 ! citrate transport [Term] id: GO:0006844 name: acyl carnitine transport namespace: biological_process def: "The directed movement of acyl carnitine into, out of, within or between cells by means of some external agent such as a transporter or pore. Acyl carnitine is the condensation product of a carboxylic acid and carnitine and is the transport form for a fatty acid crossing the mitochondrial membrane." [GOC:ai] is_a: GO:0051181 ! cofactor transport [Term] id: GO:0006845 name: mitochondrial aspartate/glutamate transport namespace: biological_process def: "OBSOLETE. The directed movement of aspartate and glutamate into, out of or within a mitochondrion." [GOC:ai] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true replaced_by: GO:0006839 replaced_by: GO:0015810 replaced_by: GO:0015813 [Term] id: GO:0006846 name: acetate transport namespace: biological_process def: "The directed movement of acetate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006847 name: plasma membrane acetate transport namespace: biological_process def: "The directed movement of acetate across a plasma membrane." [GOC:ai] is_a: GO:0035433 ! acetate transmembrane transport [Term] id: GO:0006848 name: pyruvate transport namespace: biological_process def: "The directed movement of pyruvate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] is_a: GO:0015711 ! organic anion transport is_a: GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0006849 name: plasma membrane pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, across a plasma membrane." [GOC:ai] is_a: GO:0006848 ! pyruvate transport [Term] id: GO:0006850 name: mitochondrial pyruvate transport namespace: biological_process def: "The directed movement of pyruvate, 2-oxopropanoate, into, out of or within a mitochondrion." [GOC:ai] is_a: GO:0006839 ! mitochondrial transport is_a: GO:0006848 ! pyruvate transport [Term] id: GO:0006851 name: mitochondrial calcium ion transport namespace: biological_process def: "The directed movement of calcium ions (Ca2+) into, out of or within a mitochondrion." [GOC:ai] synonym: "mitochondrial calcium transport" EXACT [] is_a: GO:0006816 ! calcium ion transport is_a: GO:0006839 ! mitochondrial transport [Term] id: GO:0006852 name: mitochondrial sodium/calcium ion exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents function rather than a process. synonym: "mitochondrial sodium/calcium exchange" EXACT [] is_obsolete: true replaced_by: GO:0006814 replaced_by: GO:0006816 replaced_by: GO:0006839 consider: GO:0005432 [Term] id: GO:0006853 name: carnitine shuttle namespace: biological_process def: "The transfer of acyl groups to and from acyl-CoA molecules to form O-acylcarnitine, which can exchange across the mitochondrial inner membrane with unacylated carnitine." [ISBN:0198547684] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. xref: Reactome:200425 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:563070 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:588683 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:609421 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:634122 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:645631 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:655959 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:661141 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:666926 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:673053 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:678957 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:689898 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:701882 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:716456 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Reactome:728416 "Import of palmitoyl-CoA into the mitochondrial matrix" xref: Wikipedia:Carnitine#Role_in_fatty_acid_metabolism is_a: GO:0003333 ! amino acid transmembrane transport is_a: GO:0006839 ! mitochondrial transport is_a: GO:0015879 ! carnitine transport is_a: GO:0015909 ! long-chain fatty acid transport is_a: GO:0032365 ! intracellular lipid transport [Term] id: GO:0006854 name: ATP/ADP exchange namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0005471 [Term] id: GO:0006855 name: drug transmembrane transport namespace: biological_process def: "The process whereby a drug is transported from one side of a membrane to the other." [GOC:ai, GOC:bf] subset: gosubset_prok synonym: "multidrug transport" RELATED [] is_a: GO:0015893 ! drug transport is_a: GO:0055085 ! transmembrane transport [Term] id: GO:0006856 name: eye pigment precursor transport namespace: biological_process def: "The directed movement of eye pigment precursors, the inactive forms of visual pigments, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] is_a: GO:0006810 ! transport relationship: part_of GO:0048066 ! developmental pigmentation [Term] id: GO:0006857 name: oligopeptide transport namespace: biological_process def: "The directed movement of oligopeptides into, out of, within or between cells by means of some external agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015833 ! peptide transport [Term] id: GO:0006858 name: extracellular transport namespace: biological_process def: "The transport of substances that occurs outside cells." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006810 ! transport [Term] id: GO:0006859 name: extracellular carbohydrate transport namespace: biological_process def: "The directed extracellular movement of carbohydrates." [GOC:ai] subset: gosubset_prok is_a: GO:0006858 ! extracellular transport is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0006860 name: extracellular amino acid transport namespace: biological_process def: "The directed extracellular movement of amino acids." [GOC:ai] is_a: GO:0006858 ! extracellular transport is_a: GO:0006865 ! amino acid transport [Term] id: GO:0006862 name: nucleotide transport namespace: biological_process def: "The directed movement of a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate, into, out of or within a cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015931 ! nucleobase, nucleoside, nucleotide and nucleic acid transport [Term] id: GO:0006863 name: purine transport namespace: biological_process alt_id: GO:0015852 def: "The directed movement of purines, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, into, out of, within or between cells by means of some external agent such as a transporter or pore." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0015851 ! nucleobase transport [Term] id: GO:0006864 name: pyrimidine nucleotide transport namespace: biological_process def: "The directed movement of a pyrimidine nucleotide, any compound consisting of a pyrimidine nucleoside esterified with (ortho)phosphate, into, out of or within a cell." [GOC:ai] is_a: GO:0006862 ! nucleotide transport [Term] id: GO:0006865 name: amino acid transport namespace: biological_process alt_id: GO:0006866 def: "The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: goslim_pir subset: gosubset_prok xref: Reactome:352230 "Amino acid transport across the plasma membrane" xref: Reactome:563378 "Amino acid transport across the plasma membrane" xref: Reactome:588999 "Amino acid transport across the plasma membrane" xref: Reactome:609720 "Amino acid transport across the plasma membrane" xref: Reactome:634415 "Amino acid transport across the plasma membrane" xref: Reactome:645877 "Amino acid transport across the plasma membrane" xref: Reactome:656195 "Amino acid transport across the plasma membrane" xref: Reactome:661334 "Amino acid transport across the plasma membrane" xref: Reactome:667117 "Amino acid transport across the plasma membrane" xref: Reactome:673259 "Amino acid transport across the plasma membrane" xref: Reactome:678946 "Amino acid transport across the plasma membrane" xref: Reactome:683867 "Amino acid transport across the plasma membrane" xref: Reactome:690121 "Amino acid transport across the plasma membrane" xref: Reactome:701866 "Amino acid transport across the plasma membrane" xref: Reactome:716440 "Amino acid transport across the plasma membrane" xref: Reactome:720949 "Amino acid transport across the plasma membrane" xref: Reactome:728400 "Amino acid transport across the plasma membrane" xref: Reactome:733142 "Amino acid transport across the plasma membrane" xref: Reactome:733947 "Amino acid transport across the plasma membrane" xref: Reactome:735685 "Amino acid transport across the plasma membrane" xref: Reactome:738621 "Amino acid transport across the plasma membrane" is_a: GO:0015837 ! amine transport is_a: GO:0046942 ! carboxylic acid transport [Term] id: GO:0006867 name: asparagine transport namespace: biological_process def: "The directed movement of asparagine, alpha-aminosuccinamic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-asparagine transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006868 name: glutamine transport namespace: biological_process alt_id: GO:0015815 def: "The directed movement of glutamine, 2-amino-4-carbamoylbutanoic acid, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:ai] subset: gosubset_prok synonym: "L-glutamine transport" NARROW [] is_a: GO:0015804 ! neutral amino acid transport [Term] id: GO:0006869 name: lipid transport namespace: biological_process def: "The directed movement of lipids into, out of, within or between cells by means of some external agent such as a transporter or pore. Lipids are compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0006810 ! transport relationship: part_of GO:0010876 ! lipid localization [Term] id: GO:0006873 name: cellular ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of ions at the level of a cell." [GOC:mah] subset: gosubset_prok is_a: GO:0050801 ! ion homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0006874 name: cellular calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of calcium ions at the level of a cell." [GOC:ceb, GOC:mah] synonym: "regulation of calcium ion concentration" BROAD [] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0055074 ! calcium ion homeostasis [Term] id: GO:0006875 name: cellular metal ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of metal ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "cellular heavy metal ion homeostasis" NARROW [] is_a: GO:0030003 ! cellular cation homeostasis is_a: GO:0055065 ! metal ion homeostasis [Term] id: GO:0006876 name: cellular cadmium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of cadmium ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cadmium homeostasis" BROAD [] is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0046916 ! cellular transition metal ion homeostasis is_a: GO:0055073 ! cadmium ion homeostasis [Term] id: GO:0006877 name: cellular cobalt ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of cobalt ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "cobalt homeostasis" BROAD [] is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0055068 ! cobalt ion homeostasis [Term] id: GO:0006878 name: cellular copper ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of copper ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "copper homeostasis" BROAD [] is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0055070 ! copper ion homeostasis [Term] id: GO:0006879 name: cellular iron ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of iron ions at the level of a cell." [GOC:ai, GOC:mah] subset: gosubset_prok synonym: "iron homeostasis" BROAD [] is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0055072 ! iron ion homeostasis [Term] id: GO:0006880 name: intracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an intracellular area such that they are separated from other components of a biological system." [GOC:ai] subset: gosubset_prok synonym: "intracellular iron ion retention" EXACT [] synonym: "intracellular iron ion sequestering" EXACT [] synonym: "intracellular iron ion sequestration" EXACT [] synonym: "intracellular iron ion storage" EXACT [] synonym: "intracellular retention of iron ion" EXACT [] synonym: "intracellular sequestration of iron ion" EXACT [] synonym: "intracellular storage of iron ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion is_a: GO:0051651 ! maintenance of location in cell relationship: part_of GO:0006879 ! cellular iron ion homeostasis [Term] id: GO:0006881 name: extracellular sequestering of iron ion namespace: biological_process def: "The process of binding or confining iron ions in an extracellular area such that they are separated from other components of a biological system." [GOC:ai] synonym: "extracellular iron ion retention" EXACT [] synonym: "extracellular iron ion sequestering" EXACT [] synonym: "extracellular iron ion sequestration" EXACT [] synonym: "extracellular iron ion storage" EXACT [] synonym: "extracellular retention of iron ion" EXACT [] synonym: "extracellular sequestration of iron ion" EXACT [] synonym: "extracellular storage of iron ion" EXACT [] is_a: GO:0051238 ! sequestering of metal ion relationship: part_of GO:0033212 ! iron assimilation [Term] id: GO:0006882 name: cellular zinc ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of zinc ions at the level of a cell." [GOC:ai, GOC:mah] synonym: "zinc homeostasis" BROAD [] is_a: GO:0030005 ! cellular di-, tri-valent inorganic cation homeostasis is_a: GO:0055069 ! zinc ion homeostasis [Term] id: GO:0006883 name: cellular sodium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of sodium ions at the level of a cell." [GOC:ai, GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0030004 ! cellular monovalent inorganic cation homeostasis is_a: GO:0055078 ! sodium ion homeostasis [Term] id: GO:0006884 name: cell volume homeostasis namespace: biological_process def: "Any process involved in maintaining the steady-state of a cell's volume. The cell's volume refers to the three-dimensional space occupied by a cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "regulation of cell volume" EXACT [GOC:dph, GOC:tb] is_a: GO:0019725 ! cellular homeostasis [Term] id: GO:0006885 name: regulation of pH namespace: biological_process def: "Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok synonym: "hydrogen ion homeostasis" EXACT [GOC:dph, GOC:tb] is_a: GO:0055067 ! monovalent inorganic cation homeostasis [Term] id: GO:0006886 name: intracellular protein transport namespace: biological_process def: "The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell." [GOC:mah] subset: gosubset_prok is_a: GO:0015031 ! protein transport is_a: GO:0046907 ! intracellular transport relationship: part_of GO:0034613 ! cellular protein localization [Term] id: GO:0006887 name: exocytosis namespace: biological_process alt_id: GO:0016194 alt_id: GO:0016195 def: "A process of secretion by a cell that results in the release of intracellular molecules (e.g. hormones, matrix proteins) contained within a membrane-bounded vesicle by fusion of the vesicle with the plasma membrane of a cell. This is the process whereby most molecules are secreted from eukaryotic cells." [GOC:mah, ISBN:0716731363] subset: gosubset_prok synonym: "nonselective vesicle exocytosis" RELATED [] synonym: "vesicle exocytosis" EXACT [] xref: Wikipedia:Exocytosis is_a: GO:0016192 ! vesicle-mediated transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0006888 name: ER to Golgi vesicle-mediated transport namespace: biological_process alt_id: GO:0048221 def: "The directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles. Small COP II coated vesicles form from the ER and then fuse directly with the cis-Golgi. Larger structures are transported along microtubules to the cis-Golgi." [GOC:ascb_2009, GOC:dph, GOC:jp, GOC:tb, ISBN:0716731363] synonym: "endoplasmic reticulum to Golgi transport" EXACT [] synonym: "endoplasmic reticulum to Golgi vesicle-mediated transport" EXACT [] synonym: "ER to Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi transport" EXACT [] synonym: "rough endoplasmic reticulum to cis-Golgi vesicle-mediated transport" EXACT [] synonym: "rough ER to cis-Golgi transport" EXACT [] synonym: "rough ER to cis-Golgi vesicle-mediated transport" EXACT [] xref: Reactome:199977 "ER to Golgi Transport" xref: Reactome:563016 "ER to Golgi Transport" xref: Reactome:588634 "ER to Golgi Transport" xref: Reactome:609369 "ER to Golgi Transport" xref: Reactome:634071 "ER to Golgi Transport" xref: Reactome:645597 "ER to Golgi Transport" xref: Reactome:655920 "ER to Golgi Transport" xref: Reactome:661121 "ER to Golgi Transport" xref: Reactome:666897 "ER to Golgi Transport" xref: Reactome:673019 "ER to Golgi Transport" xref: Reactome:678739 "ER to Golgi Transport" xref: Reactome:683672 "ER to Golgi Transport" xref: Reactome:689881 "ER to Golgi Transport" xref: Reactome:701638 "ER to Golgi Transport" xref: Reactome:716216 "ER to Golgi Transport" xref: Reactome:720781 "ER to Golgi Transport" xref: Reactome:728171 "ER to Golgi Transport" xref: Reactome:731025 "ER to Golgi Transport" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006889 name: regulation of calcium in ER namespace: biological_process def: "OBSOLETE. Any process that modulates the concentration of calcium in the endoplasmic reticulum." [GOC:go_curators] comment: This term was made obsolete because the term name is ambiguous and as a result, the term was incorrectly placed in the ontology (it was a descendant of 'protein transport'). is_obsolete: true consider: GO:0005783 consider: GO:0006874 [Term] id: GO:0006890 name: retrograde vesicle-mediated transport, Golgi to ER namespace: biological_process alt_id: GO:0048220 def: "The directed movement of substances from the Golgi back to the endoplasmic reticulum, mediated by vesicles bearing specific protein coats such as COPI or COG." [ISBN:0716731363, PMID:16510524] synonym: "cis-Golgi to rough endoplasmic reticulum transport" EXACT [] synonym: "cis-Golgi to rough endoplasmic reticulum vesicle-mediated transport" EXACT [] synonym: "cis-Golgi to rough ER transport" EXACT [] synonym: "cis-Golgi to rough ER vesicle-mediated transport" EXACT [] synonym: "retrograde (Golgi to ER) transport" EXACT [] synonym: "retrograde transport, Golgi to endoplasmic reticulum" EXACT [] synonym: "retrograde transport, Golgi to ER" EXACT [] synonym: "retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum" RELATED [] xref: Reactome:199983 "Golgi to ER Retrograde Transport" xref: Reactome:562881 "Golgi to ER Retrograde Transport" xref: Reactome:588502 "Golgi to ER Retrograde Transport" xref: Reactome:609237 "Golgi to ER Retrograde Transport" xref: Reactome:633936 "Golgi to ER Retrograde Transport" xref: Reactome:645503 "Golgi to ER Retrograde Transport" xref: Reactome:655863 "Golgi to ER Retrograde Transport" xref: Reactome:661060 "Golgi to ER Retrograde Transport" xref: Reactome:666834 "Golgi to ER Retrograde Transport" xref: Reactome:672946 "Golgi to ER Retrograde Transport" xref: Reactome:678661 "Golgi to ER Retrograde Transport" xref: Reactome:683686 "Golgi to ER Retrograde Transport" xref: Reactome:689834 "Golgi to ER Retrograde Transport" xref: Reactome:701556 "Golgi to ER Retrograde Transport" xref: Reactome:716140 "Golgi to ER Retrograde Transport" xref: Reactome:720791 "Golgi to ER Retrograde Transport" xref: Reactome:728095 "Golgi to ER Retrograde Transport" xref: Reactome:731033 "Golgi to ER Retrograde Transport" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006891 name: intra-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances within the Golgi, mediated by small transport vesicles. These either fuse with the cis-Golgi or with each other to form the membrane stacks known as the cis-Golgi reticulum (network)." [ISBN:0716731363] synonym: "intra-Golgi transport" EXACT [] is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006892 name: post-Golgi vesicle-mediated transport namespace: biological_process def: "The directed movement of substances from the Golgi to other parts of the cell, including organelles and the plasma membrane, mediated by small transport vesicles." [GOC:ai, GOC:mah] synonym: "post-Golgi transport" EXACT [] xref: Reactome:199992 "trans-Golgi Network Vesicle Budding" xref: Reactome:563184 "trans-Golgi Network Vesicle Budding" xref: Reactome:588983 "trans-Golgi Network Vesicle Budding" xref: Reactome:609732 "trans-Golgi Network Vesicle Budding" xref: Reactome:634219 "trans-Golgi Network Vesicle Budding" xref: Reactome:645893 "trans-Golgi Network Vesicle Budding" xref: Reactome:656213 "trans-Golgi Network Vesicle Budding" xref: Reactome:661343 "trans-Golgi Network Vesicle Budding" xref: Reactome:667127 "trans-Golgi Network Vesicle Budding" xref: Reactome:673268 "trans-Golgi Network Vesicle Budding" xref: Reactome:678952 "trans-Golgi Network Vesicle Budding" xref: Reactome:690128 "trans-Golgi Network Vesicle Budding" xref: Reactome:701876 "trans-Golgi Network Vesicle Budding" xref: Reactome:716450 "trans-Golgi Network Vesicle Budding" xref: Reactome:728409 "trans-Golgi Network Vesicle Budding" is_a: GO:0048193 ! Golgi vesicle transport [Term] id: GO:0006893 name: Golgi to plasma membrane transport namespace: biological_process def: "The directed movement of substances from the Golgi to the plasma membrane in transport vesicles that move from the trans-Golgi network to the plasma membrane, where they fuse and release their contents by exocytosis." [ISBN:0716731363] synonym: "Golgi to plasma membrane vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport [Term] id: GO:0006894 name: Golgi to secretory vesicle transport namespace: biological_process def: "OBSOLETE. The directed movement of proteins from the Golgi to one of two types of secretory vesicle. Continuously secreted proteins are sorted into transport vesicles that fuse with the plasma membrane, releasing their contents by exocytosis. Specialized secretory cells have a second secretory pathway in which soluble proteins and other substances are initially stored in secretory vesicles for later release." [ISBN:0716731363] comment: This term was made obsolete because it mixes two processes that can be better captured in separate terms. synonym: "Golgi to secretory vesicle transport, vesicle-mediated" EXACT [] is_obsolete: true consider: GO:0055107 consider: GO:0055108 [Term] id: GO:0006895 name: Golgi to endosome transport namespace: biological_process alt_id: GO:0048218 def: "The directed movement of substances from the Golgi to early sorting endosomes. Clathrin vesicles transport substances from the trans-Golgi to endosomes." [GOC:jl, ISBN:0716731363, PMID:10873832] synonym: "Golgi to endosome vesicle-mediated transport" EXACT [] synonym: "TGN to endosome transport" EXACT [] synonym: "trans-Golgi to endosome transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0016197 ! endosome transport [Term] id: GO:0006896 name: Golgi to vacuole transport namespace: biological_process def: "The directed movement of substances from the Golgi to the vacuole." [GOC:ai] synonym: "Golgi to vacuole vesicle-mediated transport" EXACT [] is_a: GO:0006892 ! post-Golgi vesicle-mediated transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0006897 name: endocytosis namespace: biological_process alt_id: GO:0016193 alt_id: GO:0016196 def: "A type of vesicle-mediated transport in which cells take up external materials or membrane constituents by the invagination of small region of the plasma membrane to form a new membrane-bounded vesicle." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0716731363] subset: gosubset_prok synonym: "nonselective vesicle endocytosis" RELATED [] synonym: "plasma membrane invagination" EXACT [] synonym: "vesicle endocytosis" EXACT [] xref: Wikipedia:Endocytosis is_a: GO:0010324 ! membrane invagination is_a: GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006898 name: receptor-mediated endocytosis namespace: biological_process def: "The uptake of external materials by cells, utilizing receptors to ensure specificity of transport. A specific receptor on the cell surface binds tightly to the extracellular macromolecule (the ligand) that it recognizes; the plasma-membrane region containing the receptor-ligand complex then undergoes endocytosis, forming a transport vesicle containing the receptor-ligand complex and excluding most other plasma-membrane proteins. Receptor-mediated endocytosis generally occurs via clathrin-coated pits and vesicles." [ISBN:0716731363] synonym: "receptor mediated endocytosis" EXACT [] xref: Reactome:171052 "LDL endocytosis" xref: Reactome:171059 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:171087 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:171106 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:171118 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:171122 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:171141 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)" xref: Reactome:174624 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:174657 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:174808 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:545428 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:545455 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:545471 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:554427 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:554436 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:554438 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:554454 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:554455 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:563266 "LDL endocytosis" xref: Reactome:572417 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:572434 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:572445 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:580247 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:580251 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:580253 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:580259 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:580260 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:588875 "LDL endocytosis" xref: Reactome:603184 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:603193 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:603198 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:603204 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:603205 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:609590 "LDL endocytosis" xref: Reactome:619332 "chylomicron remnant:apoE complex + LDLR => chylomicron remnant:apoE:LDLR complex" xref: Reactome:619354 "chylomicron remnant:apoE:LDLR complex => chylomicron remnant:apoE + LDLR" xref: Reactome:619368 "chylomicron remnant:apoE:LDLR complex [coated vesicle membrane] => chylomicron remnant:apoE:LDLR complex [endosome membrane]" xref: Reactome:627141 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:627147 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-dependent)" xref: Reactome:627149 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:627159 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:627160 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:634300 "LDL endocytosis" xref: Reactome:641950 "LDL + LDLR => LDL:LDLR complex" xref: Reactome:641957 "LDL:LDLR complex [plasma membrane] => LDL:LDLR complex [clathrin-coated vesicle] (LDLRAP1-independent)" xref: Reactome:641961 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:641967 "LDLR:LDL complex => LDLR + LDL" xref: Reactome:641968 "LDLR:LDL complex [coated vesicle membrane] => LDLR:LDL complex [endosome membrane]" xref: Reactome:645768 "LDL endocytosis" xref: Reactome:652582 "LDLR [endosome membrane] => LDLR [plasma membrane]" xref: Reactome:656095 "LDL endocytosis" xref: Wikipedia:Receptor-mediated_endocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006900 name: membrane budding namespace: biological_process alt_id: GO:0006902 def: "The evagination of a membrane, resulting in formation of a vesicle." [GOC:jid, GOC:tb] synonym: "membrane evagination" EXACT [] synonym: "nonselective vesicle assembly" RELATED [] synonym: "vesicle biosynthesis" EXACT [] synonym: "vesicle budding" RELATED [] synonym: "vesicle formation" EXACT [] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006901 name: vesicle coating namespace: biological_process def: "A protein coat is added to the vesicle to form the proper shape of the vesicle and to target the vesicle for transport to its destination." [GOC:jid] synonym: "vesicle coat assembly" BROAD [] is_a: GO:0016050 ! vesicle organization relationship: part_of GO:0006900 ! membrane budding [Term] id: GO:0006903 name: vesicle targeting namespace: biological_process def: "The process by which vesicles are directed to specific destination membranes. Targeting involves coordinated interactions among cytoskeletal elements (microtubules or actin filaments), motor proteins, molecules at the vesicle membrane and target membrane surfaces, and vesicle cargo." [GOC:mah, PMID:17335816] is_a: GO:0009987 ! cellular process relationship: part_of GO:0016192 ! vesicle-mediated transport relationship: part_of GO:0051650 ! establishment of vesicle localization [Term] id: GO:0006904 name: vesicle docking involved in exocytosis namespace: biological_process def: "The initial attachment of a vesicle membrane to a target membrane, mediated by proteins protruding from the membrane of the vesicle and the target membrane, that contributes to exocytosis." [GOC:jid] subset: gosubset_prok synonym: "vesicle docking during exocytosis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048278 ! vesicle docking relationship: part_of GO:0006887 ! exocytosis [Term] id: GO:0006905 name: vesicle transport namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because the meaning of the term is ambiguous. is_obsolete: true consider: GO:0016192 [Term] id: GO:0006906 name: vesicle fusion namespace: biological_process def: "Fusion of the membrane of a transport vesicle with its target membrane." [GOC:jid] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0016050 ! vesicle organization is_a: GO:0048284 ! organelle fusion relationship: part_of GO:0016192 ! vesicle-mediated transport [Term] id: GO:0006907 name: pinocytosis namespace: biological_process def: "The process whereby cells take in liquid material from their external environment; literally 'cell drinking'. Liquid is enclosed in vesicles, formed by invagination of the plasma membrane. These vesicles then move into the cell and pass their contents to endosomes." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "fluid-phase endocytosis" EXACT [] xref: Wikipedia:Pinocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006908 name: clathrin-independent pinocytosis namespace: biological_process is_a: GO:0006907 ! pinocytosis [Term] id: GO:0006909 name: phagocytosis namespace: biological_process def: "The process whereby phagocytes engulf external particulate material. The particles are initially contained within phagocytic vacuoles (phagosomes), which then fuse with primary lysosomes to effect digestion of the particles." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Phagocytosis is_a: GO:0006897 ! endocytosis [Term] id: GO:0006910 name: phagocytosis, recognition namespace: biological_process def: "The initial step in phagocytosis involving adhesion to bacteria, immune complexes and other particulate matter, or an apoptotic cell and based on recognition of factors such as bacterial cell wall components, opsonins like complement and antibody or protein receptors and lipids like phosphatidyl serine, and leading to intracellular signaling in the phagocytosing cell." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] comment: Note that cell surface molecules involved in the direct binding of bacteria may be also annotated to the molecular function term 'bacterial cell surface binding ; GO:0051635'. Note that cell surface molecules involved in the direct binding to opsonins such as complement components or antibodies may be also annotated to the term 'opsonin binding ; GO:0001846'. synonym: "recognition of phagocytosed substance by phagocytic cell" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006911 name: phagocytosis, engulfment namespace: biological_process def: "The internalization of bacteria, immune complexes and other particulate matter or of an apoptotic cell by phagocytosis, including the membrane and cytoskeletal processes required, which involves one of three mechanisms: zippering of pseudopods around a target via repeated receptor-ligand interactions, sinking of the target directly into plasma membrane of the phagocytosing cell, or induced uptake via an enhanced membrane ruffling of the phagocytosing cell similar to macropinocytosis." [GOC:curators, ISBN:0781735149 "Fundamental Immunology"] synonym: "phagosome biosynthesis" RELATED [] synonym: "phagosome formation" RELATED [] is_a: GO:0010324 ! membrane invagination relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0006912 name: phagosome formation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:hjd] comment: This term was made obsolete because of the ambiguity in its meaning. is_obsolete: true consider: GO:0001845 consider: GO:0006911 [Term] id: GO:0006913 name: nucleocytoplasmic transport namespace: biological_process alt_id: GO:0000063 def: "The directed movement of molecules between the nucleus and the cytoplasm." [GOC:go_curators] subset: goslim_pombe synonym: "nucleocytoplasmic shuttling" NARROW [] is_a: GO:0051169 ! nuclear transport [Term] id: GO:0006914 name: autophagy namespace: biological_process def: "The process by which cells digest parts of their own cytoplasm; allows for both recycling of macromolecular constituents under conditions of cellular stress and remodeling the intracellular structure for cell differentiation." [ISBN:0198547684, PMID:11099404, PMID:9412464] subset: goslim_pir xref: Wikipedia:Autophagy_(cellular) is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0006915 name: apoptosis namespace: biological_process alt_id: GO:0008632 def: "A form of programmed cell death that begins when a cell receives internal or external signals that trigger the activity of proteolytic caspases, proceeds through a series of characteristic stages typically including rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), and plasma membrane blebbing (but maintenance of its integrity until the final stages of the process), and ends with the death of the cell." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:18846107] synonym: "apoptotic cell death" EXACT [GOC:sl] synonym: "apoptotic program" NARROW [GOC:add] synonym: "apoptotic programmed cell death" EXACT [] synonym: "programmed cell death by apoptosis" EXACT [] synonym: "signaling (initiator) caspase activity" RELATED [] synonym: "type I programmed cell death" NARROW [] xref: Reactome:109581 "Apoptosis" xref: Reactome:193648 "NRAGE signals death through JNK" xref: Reactome:205025 "NADE modulates death signalling" xref: Reactome:205043 "NRIF signals cell death from the nucleus" xref: Reactome:562574 "NADE modulates death signalling" xref: Reactome:562736 "Apoptosis" xref: Reactome:562811 "NRAGE signals death through JNK" xref: Reactome:563213 "NRIF signals cell death from the nucleus" xref: Reactome:588200 "NADE modulates death signalling" xref: Reactome:588356 "Apoptosis" xref: Reactome:588427 "NRAGE signals death through JNK" xref: Reactome:588818 "NRIF signals cell death from the nucleus" xref: Reactome:609167 "NRAGE signals death through JNK" xref: Reactome:609274 "Apoptosis" xref: Reactome:609542 "NRIF signals cell death from the nucleus" xref: Reactome:633794 "Apoptosis" xref: Reactome:633861 "NRAGE signals death through JNK" xref: Reactome:634341 "NRIF signals cell death from the nucleus" xref: Reactome:645445 "NRAGE signals death through JNK" xref: Reactome:645529 "Apoptosis" xref: Reactome:655808 "NRAGE signals death through JNK" xref: Reactome:655895 "Apoptosis" xref: Reactome:661076 "Apoptosis" xref: Reactome:661286 "NRAGE signals death through JNK" xref: Reactome:666859 "Apoptosis" xref: Reactome:672975 "Apoptosis" xref: Reactome:673212 "NRAGE signals death through JNK" xref: Reactome:678693 "Apoptosis" xref: Reactome:683629 "Apoptosis" xref: Reactome:690116 "Apoptosis" xref: Reactome:701828 "NRAGE signals death through JNK" xref: Reactome:701861 "Apoptosis" xref: Reactome:716403 "NRAGE signals death through JNK" xref: Reactome:716435 "Apoptosis" xref: Reactome:720755 "Apoptosis" xref: Reactome:720894 "NRAGE signals death through JNK" xref: Reactome:728128 "Apoptosis" xref: Reactome:728356 "NRAGE signals death through JNK" xref: Reactome:731177 "Apoptosis" xref: Wikipedia:Apoptosis is_a: GO:0012501 ! programmed cell death [Term] id: GO:0006916 name: anti-apoptosis namespace: biological_process def: "A process which directly inhibits any of the steps required for cell death by apoptosis." [GOC:go_curators] synonym: "apoptosis inhibitor activity" RELATED [] xref: Reactome:193639 "p75NTR signals via NF-kB" xref: Reactome:563243 "p75NTR signals via NF-kB" xref: Reactome:588850 "p75NTR signals via NF-kB" xref: Reactome:609571 "p75NTR signals via NF-kB" xref: Reactome:634277 "p75NTR signals via NF-kB" xref: Reactome:645752 "p75NTR signals via NF-kB" is_a: GO:0043066 ! negative regulation of apoptosis [Term] id: GO:0006917 name: induction of apoptosis namespace: biological_process def: "A process that directly activates any of the steps required for cell death by apoptosis." [GOC:go_curators] synonym: "activation of apoptosis" EXACT [] synonym: "apoptosis activator activity" RELATED [] synonym: "apoptosis signaling" BROAD [] synonym: "commitment to apoptosis" EXACT [] synonym: "induction of apoptosis by p53" NARROW [] is_a: GO:0012502 ! induction of programmed cell death is_a: GO:0043065 ! positive regulation of apoptosis [Term] id: GO:0006918 name: induction of apoptosis by p53 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. is_obsolete: true consider: GO:0006917 [Term] id: GO:0006919 name: activation of caspase activity namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase] synonym: "caspase activation" EXACT [GOC:dph, GOC:tb] xref: Reactome:563171 "Activation of Pro-Caspase 8" xref: Reactome:588780 "Activation of Pro-Caspase 8" xref: Reactome:609508 "Activation of Pro-Caspase 8" xref: Reactome:634428 "Activation of Pro-Caspase 8" xref: Reactome:69416 "Activation of Pro-Caspase 8" xref: Reactome:75142 "Activation of Effector Caspases" is_a: GO:0043280 ! positive regulation of caspase activity relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0006920 name: commitment to apoptosis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more accurate terms were created. is_obsolete: true consider: GO:0006917 [Term] id: GO:0006921 name: cellular component disassembly involved in apoptosis namespace: biological_process def: "The breakdown of structures such as organelles, proteins, or other macromolecular structures during apoptosis." [GOC:dph, GOC:mah, GOC:tb] synonym: "disassembly of cell structures" BROAD [] xref: Reactome:562911 "Apoptotic execution phase" xref: Reactome:588532 "Apoptotic execution phase" xref: Reactome:609273 "Apoptotic execution phase" xref: Reactome:633966 "Apoptotic execution phase" xref: Reactome:645528 "Apoptotic execution phase" xref: Reactome:655894 "Apoptotic execution phase" xref: Reactome:661075 "Apoptotic execution phase" xref: Reactome:666858 "Apoptotic execution phase" xref: Reactome:672974 "Apoptotic execution phase" xref: Reactome:678692 "Apoptotic execution phase" xref: Reactome:683628 "Apoptotic execution phase" xref: Reactome:720754 "Apoptotic execution phase" xref: Reactome:728127 "Apoptotic execution phase" xref: Reactome:75153 "Apoptotic execution phase" is_a: GO:0022411 ! cellular component disassembly relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0006922 name: cleavage of lamin namespace: biological_process def: "The proteolytic degradation of lamins during apoptosis, leading to the irreversible breakdown of the nuclear lamina." [GOC:mah, ISBN:0815332181] is_a: GO:0006923 ! cleavage of cytoskeletal proteins involved in apoptosis [Term] id: GO:0006923 name: cleavage of cytoskeletal proteins involved in apoptosis namespace: biological_process def: "The proteolytic degradation of cytoskeletal proteins that contributes to apoptosis, leading to the collapse of cytoskeletal structures." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815332181] synonym: "apoptotic cleavage of cytoskeletal proteins" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process relationship: part_of GO:0006921 ! cellular component disassembly involved in apoptosis relationship: part_of GO:0007010 ! cytoskeleton organization [Term] id: GO:0006924 name: activation-induced cell death of T cells namespace: biological_process def: "A type of T cell apoptosis that occurs towards the end of the expansion phase following the initial activation of mature T cells by antigen and is triggered by T cell receptor stimulation and signals transmitted via various surface-expressed members of the TNF receptor family such as Fas ligand, Fas, and TNF and the p55 and p75 TNF receptors." [GOC:add, ISBN:0781765196, PMID:12414721, PMID:12752672] synonym: "activated T cell apoptosis" BROAD [GOC:add] synonym: "activation-induced cell death of T lymphocytes" EXACT [GOC:add] synonym: "activation-induced cell death of T-cells" EXACT [GOC:add] synonym: "activation-induced cell death of T-lymphocytes" EXACT [GOC:add] synonym: "AICD" BROAD [GOC:add] synonym: "antigen-driven apoptosis" BROAD [GOC:add] is_a: GO:0070231 ! T cell apoptosis relationship: part_of GO:0043029 ! T cell homeostasis [Term] id: GO:0006925 name: inflammatory cell apoptosis namespace: biological_process def: "The process of apoptosis in inflammatory cells, any cell participating in the inflammatory response to a foreign substance e.g. neutrophil, macrophage." [GOC:jl, http://www.mercksource.com/] synonym: "apoptosis of inflammatory cells" EXACT [] synonym: "inflammatory cell programmed cell death by apoptosis" EXACT [] synonym: "killing of inflammatory cells" EXACT [] synonym: "programmed cell death of inflammatory cells by apoptosis" EXACT [] synonym: "programmed cell death, inflammatory cells" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006926 name: virus-infected cell apoptosis namespace: biological_process def: "The process of apoptosis in cells infected with a virus." [GOC:jl] synonym: "apoptosis of virus-infected cells" EXACT [] synonym: "killing virus-infected cells" EXACT [] synonym: "programmed cell death of virus-infected cells by apoptosis" EXACT [] synonym: "programmed cell death, virus-infected cells" EXACT [] synonym: "virus-infected cell programmed cell death by apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006927 name: transformed cell apoptosis namespace: biological_process def: "The process of apoptosis in transformed cells, cells that have undergone changes manifested by escape from control mechanisms, increased growth potential, alterations in the cell surface, karyotypic abnormalities, morphological and biochemical deviations from the norm." [GOC:jl, MeSH:C04.697.152] synonym: "apoptosis of transformed cells" EXACT [] synonym: "killing transformed cells" EXACT [] synonym: "programmed cell death of transformed cells by apoptosis" EXACT [] synonym: "programmed cell death, transformed cells" EXACT [] synonym: "transformed cell programmed cell death by apoptosis" EXACT [] is_a: GO:0006915 ! apoptosis [Term] id: GO:0006928 name: cellular component movement namespace: biological_process def: "The directed, self-propelled movement of a cellular component without the involvement of an external agent such as a transporter or a pore." [GOC:dgh, GOC:dph, GOC:jl, GOC:mlg] comment: Note that in GO cellular components include whole cells (cell is_a cellular component). subset: goslim_goa subset: goslim_pir subset: gosubset_prok synonym: "cell movement" RELATED [] synonym: "cellular component motion" EXACT [GOC:dph, GOC:jl] is_a: GO:0009987 ! cellular process [Term] id: GO:0006929 name: substrate-bound cell migration namespace: biological_process def: "The orderly movement of a cell from one site to another along a substrate such as the extracellular matrix; the migrating cell forms a protrusion that attaches to the substrate." [ISBN:0815316194, PMID:11944043, PMID:14657486] is_a: GO:0016477 ! cell migration [Term] id: GO:0006930 name: substrate-bound cell migration, cell extension namespace: biological_process def: "The formation of a cell surface protrusion, such as a lamellipodium or filopodium, at the leading edge of a migrating cell." [ISBN:0815316194, PMID:11944043, PMID:14657486] is_a: GO:0030031 ! cell projection assembly relationship: part_of GO:0006929 ! substrate-bound cell migration [Term] id: GO:0006931 name: substrate-bound cell migration, cell attachment to substrate namespace: biological_process def: "The formation of adhesions that stabilize protrusions at the leading edge of a migrating cell; involves integrin activation, clustering, and the recruitment of structural and signaling components to nascent adhesions." [ISBN:0815316194, PMID:11944043, PMID:14657486] is_a: GO:0031589 ! cell-substrate adhesion relationship: part_of GO:0006929 ! substrate-bound cell migration [Term] id: GO:0006932 name: substrate-bound cell migration, cell contraction namespace: biological_process def: "The translocation of the cell body forward during cell migration, mediated by tractional force on its substrate and tension in the cortical cytoskeleton. Adhesions transmit propulsive forces and serve as traction points over which the cell moves." [ISBN:0815316194, PMID:11944043, PMID:14657486] is_a: GO:0070252 ! actin-mediated cell contraction relationship: part_of GO:0001667 ! ameboidal cell migration relationship: part_of GO:0006929 ! substrate-bound cell migration [Term] id: GO:0006933 name: negative regulation of cell adhesion involved in substrate-bound cell migration namespace: biological_process def: "The disassembly of adhesions at the front and rear of a migrating cell. At the leading edge, adhesion disassembly accompanies the formation of new protrusions; at the cell rear, it promotes tail retraction." [GOC:dph, GOC:tb, ISBN:0815316194, PMID:11944043, PMID:14657486] synonym: "substrate-bound cell migration, cell release from substrate" EXACT [GOC:dph, GOC:tb] is_a: GO:0007162 ! negative regulation of cell adhesion relationship: part_of GO:0006929 ! substrate-bound cell migration [Term] id: GO:0006934 name: substrate-bound cell migration, adhesion receptor recycling namespace: biological_process def: "The directed movement of accumulated adhesion components such as integrins from the rear of a migrating cell toward the cell front, where they are available to form new protrusions and adhesions." [PMID:11944043] is_a: GO:0001881 ! receptor recycling relationship: part_of GO:0006933 ! negative regulation of cell adhesion involved in substrate-bound cell migration [Term] id: GO:0006935 name: chemotaxis namespace: biological_process def: "The directed movement of a motile cell or organism, or the directed growth of a cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "taxis in response to chemical stimulus" EXACT [] xref: Wikipedia:Chemotaxis is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0042330 ! taxis [Term] id: GO:0006936 name: muscle contraction namespace: biological_process def: "A process whereby force is generated within muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis." [GOC:ef, GOC:mtg_muscle, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: Reactome:445355 "Smooth Muscle Contraction" xref: Reactome:562942 "Smooth Muscle Contraction" xref: Reactome:588563 "Smooth Muscle Contraction" xref: Reactome:609303 "Smooth Muscle Contraction" xref: Reactome:633994 "Smooth Muscle Contraction" xref: Reactome:645552 "Smooth Muscle Contraction" xref: Reactome:655891 "Smooth Muscle Contraction" xref: Reactome:661108 "Smooth Muscle Contraction" xref: Reactome:666886 "Smooth Muscle Contraction" xref: Reactome:673008 "Smooth Muscle Contraction" xref: Reactome:678729 "Smooth Muscle Contraction" xref: Reactome:683667 "Smooth Muscle Contraction" xref: Reactome:689873 "Smooth Muscle Contraction" xref: Reactome:701634 "Smooth Muscle Contraction" xref: Reactome:716212 "Smooth Muscle Contraction" xref: Reactome:720777 "Smooth Muscle Contraction" xref: Reactome:728161 "Smooth Muscle Contraction" xref: Reactome:731017 "Smooth Muscle Contraction" xref: Wikipedia:Muscle_contraction is_a: GO:0003012 ! muscle system process [Term] id: GO:0006937 name: regulation of muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of muscle contraction." [GOC:go_curators] is_a: GO:0090257 ! regulation of muscle system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006936 ! muscle contraction relationship: regulates GO:0006936 ! muscle contraction [Term] id: GO:0006939 name: smooth muscle contraction namespace: biological_process def: "A process whereby force is generated within smooth muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Smooth muscle differs from striated muscle in the much higher actin/myosin ratio, the absence of conspicuous sarcomeres and the ability to contract to a much smaller fraction of its resting length." [GOC:ef, GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "visceral muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006940 name: regulation of smooth muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of smooth muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006939 ! smooth muscle contraction relationship: regulates GO:0006939 ! smooth muscle contraction [Term] id: GO:0006941 name: striated muscle contraction namespace: biological_process def: "A process whereby force is generated within striated muscle tissue, resulting in the shortening of the muscle. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. Striated muscle is a type of muscle in which the repeating units (sarcomeres) of the contractile myofibrils are arranged in registry throughout the cell, resulting in transverse or oblique striations observable at the level of the light microscope." [GOC:jl, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sarcomeric muscle contraction" EXACT [] is_a: GO:0006936 ! muscle contraction [Term] id: GO:0006942 name: regulation of striated muscle contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of striated muscle contraction." [GOC:go_curators] is_a: GO:0006937 ! regulation of muscle contraction intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006941 ! striated muscle contraction relationship: regulates GO:0006941 ! striated muscle contraction [Term] id: GO:0006943 name: chemi-mechanical coupling namespace: biological_process def: "OBSOLETE. The conversion of chemical energy into mechanical work (as in the contraction of a muscle)." [GOC:jid, http://www.m-w.com] comment: This term was made obsolete because its meaning is vague, and it does not fit with other terms in GO. synonym: "mechanochemical coupling" EXACT [] is_obsolete: true consider: GO:0009612 consider: GO:0050954 [Term] id: GO:0006944 name: cellular membrane fusion namespace: biological_process def: "The cellular process that joins two lipid bilayers to form a single membrane." [GOC:mah] subset: goslim_goa xref: Wikipedia:Lipid_bilayer_fusion is_a: GO:0016044 ! cellular membrane organization is_a: GO:0061025 ! membrane fusion [Term] id: GO:0006945 name: nuclear fusion during karyogamy namespace: biological_process def: "OBSOLETE. The fusion of two haploid nuclei to form a single diploid nucleus, as seen in the yeast mating process." [PMID:9442101] comment: This term was made obsolete because it is redundant outside the context of Saccharomyces biology. is_obsolete: true consider: GO:0000741 [Term] id: GO:0006948 name: induction by virus of host cell-cell fusion namespace: biological_process def: "The process of syncytia-forming cell-cell fusion, caused by a virus." [ISBN:0781718325] synonym: "induction by virus of cell-cell fusion in host" EXACT [] synonym: "viral-induced cell-cell fusion" EXACT [] synonym: "viral-induced host cell-cell fusion" EXACT [] synonym: "viral-induced membrane fusion" NARROW [] is_a: GO:0019048 ! virus-host interaction [Term] id: GO:0006949 name: syncytium formation namespace: biological_process def: "The formation of a syncytium, a mass of cytoplasm containing several nuclei enclosed within a single plasma membrane. Syncytia are normally derived from single cells that fuse or fail to complete cell division." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir is_a: GO:0009987 ! cellular process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis [Term] id: GO:0006950 name: response to stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation)." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "response to abiotic stress" RELATED [] synonym: "response to biotic stress" RELATED [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006952 name: defense response namespace: biological_process alt_id: GO:0002217 alt_id: GO:0042829 def: "Reactions, triggered in response to the presence of a foreign body or the occurrence of an injury, which result in restriction of damage to the organism attacked or prevention/recovery from the infection caused by the attack." [GOC:go_curators] subset: gosubset_prok synonym: "antimicrobial peptide activity" RELATED [] synonym: "defence response" EXACT [] synonym: "defense/immunity protein activity" RELATED [] synonym: "physiological defense response" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0006953 name: acute-phase response namespace: biological_process def: "Process involving non-antibody proteins whose concentrations in the plasma increase in response to infection or injury of homeothermic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0002526 ! acute inflammatory response [Term] id: GO:0006954 name: inflammatory response namespace: biological_process def: "The immediate defensive reaction (by vertebrate tissue) to infection or injury caused by chemical or physical agents. The process is characterized by local vasodilation, extravasation of plasma into intercellular spaces and accumulation of white blood cells and macrophages." [GO_REF:0000022, GOC:mtg_15nov05, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was improved by GO_REF:0000022. It was moved. xref: Wikipedia:Inflammation is_a: GO:0006952 ! defense response is_a: GO:0009611 ! response to wounding [Term] id: GO:0006955 name: immune response namespace: biological_process def: "Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05] comment: This term was improved by GO_REF:0000022. It was redefined and moved. is_a: GO:0002376 ! immune system process is_a: GO:0050896 ! response to stimulus [Term] id: GO:0006956 name: complement activation namespace: biological_process def: "Any process involved in the activation of any of the steps of the complement cascade, which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes; the initial steps of complement activation involve one of three pathways, the classical pathway, the alternative pathway, and the lectin pathway, all of which lead to the terminal complement pathway." [GO_REF:0000022, GOC:add, GOC:mtg_15nov05, ISBN:0781735149 "Fundamental Immunology"] comment: This term was improved by GO_REF:0000022. It was moved. synonym: "complement activity" RELATED [] synonym: "complement response" EXACT [] xref: Reactome:166663 "Initial triggering of complement" xref: Reactome:562785 "Initial triggering of complement" xref: Reactome:588401 "Initial triggering of complement" xref: Reactome:609138 "Initial triggering of complement" xref: Reactome:634056 "Initial triggering of complement" is_a: GO:0002252 ! immune effector process is_a: GO:0002253 ! activation of immune response is_a: GO:0002541 ! activation of plasma proteins involved in acute inflammatory response is_a: GO:0006959 ! humoral immune response [Term] id: GO:0006957 name: complement activation, alternative pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the alternative pathway of the complement cascade which allows for the direct killing of microbes and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: Reactome:173736 "Alternative complement activation" xref: Reactome:563004 "Alternative complement activation" xref: Reactome:588621 "Alternative complement activation" xref: Reactome:609395 "Alternative complement activation" xref: Reactome:634055 "Alternative complement activation" is_a: GO:0006956 ! complement activation is_a: GO:0045087 ! innate immune response [Term] id: GO:0006958 name: complement activation, classical pathway namespace: biological_process def: "Any process involved in the activation of any of the steps of the classical pathway of the complement cascade which allows for the direct killing of microbes, the disposal of immune complexes, and the regulation of other immune processes." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] xref: Reactome:173623 "Classical antibody-mediated complement activation" is_a: GO:0006956 ! complement activation relationship: part_of GO:0002455 ! humoral immune response mediated by circulating immunoglobulin [Term] id: GO:0006959 name: humoral immune response namespace: biological_process def: "An immune response mediated through a body fluid." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Humoral_immunity is_a: GO:0006955 ! immune response [Term] id: GO:0006962 name: male-specific antibacterial humoral response namespace: biological_process def: "An immune response against bacteria, specific to males and mediated through a body fluid." [GOC:go_curators] is_a: GO:0019731 ! antibacterial humoral response is_a: GO:0050831 ! male-specific defense response to bacterium [Term] id: GO:0006963 name: positive regulation of antibacterial peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antibacterial peptide biosynthesis." [GOC:mah, PMID:10973475] synonym: "activation of antibacterial peptide biosynthetic process" NARROW [] synonym: "antibacterial peptide induction" EXACT [] synonym: "antibacterial polypeptide induction" EXACT [] synonym: "stimulation of antibacterial peptide biosynthetic process" NARROW [] synonym: "up regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "up-regulation of antibacterial peptide biosynthetic process" EXACT [] synonym: "upregulation of antibacterial peptide biosynthetic process" EXACT [] is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002808 ! regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process relationship: positively_regulates GO:0002780 ! antibacterial peptide biosynthetic process [Term] id: GO:0006964 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-negative bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "anti-Gram-negative bacterial peptide induction" EXACT [] synonym: "anti-Gram-negative bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria" EXACT [] is_a: GO:0002813 ! regulation of biosynthetic process of antibacterial peptides active against Gram-negative bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria relationship: positively_regulates GO:0002812 ! biosynthetic process of antibacterial peptides active against Gram-negative bacteria [Term] id: GO:0006965 name: positive regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of biosynthesis of antibacterial peptides active against Gram-positive bacteria." [GOC:mah, PMID:10973475] synonym: "activation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "anti-Gram-positive bacterial peptide induction" EXACT [] synonym: "anti-Gram-positive bacterial polypeptide induction" EXACT [] synonym: "stimulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" NARROW [] synonym: "up regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "up-regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] synonym: "upregulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria" EXACT [] is_a: GO:0002816 ! regulation of biosynthetic process of antibacterial peptides active against Gram-positive bacteria is_a: GO:0006963 ! positive regulation of antibacterial peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria relationship: positively_regulates GO:0002815 ! biosynthetic process of antibacterial peptides active against Gram-positive bacteria [Term] id: GO:0006967 name: positive regulation of antifungal peptide biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate, or extent of antifungal peptide biosynthesis." [GOC:mah] synonym: "activation of antifungal peptide biosynthetic process" NARROW [] synonym: "antifungal peptide induction" EXACT [] synonym: "antifungal polypeptide induction" EXACT [] synonym: "stimulation of antifungal peptide biosynthetic process" NARROW [] synonym: "up regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "up-regulation of antifungal peptide biosynthetic process" EXACT [] synonym: "upregulation of antifungal peptide biosynthetic process" EXACT [] is_a: GO:0002807 ! positive regulation of antimicrobial peptide biosynthetic process is_a: GO:0002810 ! regulation of antifungal peptide biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process relationship: positively_regulates GO:0002783 ! antifungal peptide biosynthetic process [Term] id: GO:0006968 name: cellular defense response namespace: biological_process alt_id: GO:0016066 alt_id: GO:0016067 def: "A defense response that is mediated by cells." [GOC:ebc] comment: Note that this term refers to any type of defense response made by any cell, whether only a single-celled organism or part of a multicellular organism; also includes responses that occur in the context of multiorganism processes. synonym: "cellular defence response" EXACT [] is_a: GO:0006952 ! defense response [Term] id: GO:0006969 name: melanotic tumor response namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:add] comment: This term was made obsolete because it was undefined and represented an abnormal process. synonym: "melanotic mass response" EXACT [] is_obsolete: true [Term] id: GO:0006970 name: response to osmotic stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell." [GOC:jl] subset: gosubset_prok synonym: "osmotic response" EXACT [] synonym: "osmotic stress response" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0006971 name: hypotonic response namespace: biological_process def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hypotonic environment, i.e. an environment with a lower concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "hypo-osmotic response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006972 name: hyperosmotic response namespace: biological_process def: "A change in state or activity of a cell or an organism or cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a hyperosmotic environment, i.e. an environment with a higher concentration of solutes than the organism or cell." [GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "HOG response" EXACT [] synonym: "hypertonic response" EXACT [] synonym: "response to hypertonicity" EXACT [GOC:mah, GOC:yaf] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0006973 name: intracellular accumulation of glycerol namespace: biological_process def: "The accumulation of glycerol within a cell, for example by increased glycerol biosynthesis combined with decreased permeability of the cell membrane to glycerol, in response to the detection of a hyperosmotic environment." [GOC:jl, PMID:11752666] is_a: GO:0019725 ! cellular homeostasis relationship: part_of GO:0071474 ! cellular hyperosmotic response [Term] id: GO:0006974 name: response to DNA damage stimulus namespace: biological_process alt_id: GO:0034984 def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism." [GOC:go_curators] subset: gosubset_prok synonym: "cellular DNA damage response" EXACT [] synonym: "cellular response to DNA damage stimulus" EXACT [] synonym: "DNA damage response" EXACT [] synonym: "response to genotoxic stress" EXACT [] is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0006975 name: DNA damage induced protein phosphorylation namespace: biological_process def: "The widespread phosphorylation of various molecules, triggering many downstream processes, that occurs in response to the detection of DNA damage." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006468 ! protein amino acid phosphorylation is_a: GO:0006974 ! response to DNA damage stimulus [Term] id: GO:0006977 name: DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, in response to the detection of DNA damage and resulting in the stopping or reduction in rate of the cell cycle." [GOC:go_curators] synonym: "positive regulation of cell cycle arrest by p53-mediated DNA damage response" EXACT [GOC:dph, GOC:mah] xref: Reactome:562958 "p53-Dependent G1 DNA Damage Response" xref: Reactome:588854 "p53-Dependent G1 DNA Damage Response" xref: Reactome:609319 "p53-Dependent G1 DNA Damage Response" xref: Reactome:634010 "p53-Dependent G1 DNA Damage Response" xref: Reactome:683632 "p53-Dependent G1 DNA Damage Response" xref: Reactome:690093 "p53-Dependent G1 DNA Damage Response" xref: Reactome:69563 "p53-Dependent G1 DNA Damage Response" xref: Reactome:701596 "p53-Dependent G1 DNA Damage Response" xref: Reactome:716181 "p53-Dependent G1 DNA Damage Response" xref: Reactome:728131 "p53-Dependent G1 DNA Damage Response" is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0071158 ! positive regulation of cell cycle arrest relationship: part_of GO:0031571 ! G1/S DNA damage checkpoint [Term] id: GO:0006978 name: DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator namespace: biological_process def: "A cascade of processes induced by the cell cycle regulator phosphoprotein p53, or an equivalent protein, resulting in the induction of the transcription of p21 (also known as WAF1, CIP1 and SDI1) or any equivalent protein, in response to the detection of DNA damage." [PMID:10967424] is_a: GO:0030330 ! DNA damage response, signal transduction by p53 class mediator is_a: GO:0042772 ! DNA damage response, signal transduction resulting in transcription [Term] id: GO:0006979 name: response to oxidative stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals." [GOC:jl, PMID:12115731] subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0006981 name: activation of SoxR protein namespace: biological_process def: "The conversion of the SoxR transcription factor to its active (oxidized) form." [GOC:jl, PMID:8816757] subset: gosubset_prok is_a: GO:0070887 ! cellular response to chemical stimulus is_a: GO:0071461 ! cellular response to redox state [Term] id: GO:0006982 name: response to lipid hydroperoxide namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid hydroperoxide stimulus. Lipid hydroperoxide is the highly reactive primary oxygenated products of polyunsaturated fatty acids." [GOC:jl, PMID:10944149] subset: gosubset_prok synonym: "response to LHPO" EXACT [] is_a: GO:0033194 ! response to hydroperoxide [Term] id: GO:0006983 name: ER overload response namespace: biological_process def: "The series of molecular signals generated by the accumulation of normal or misfolded proteins in the endoplasmic reticulum and leading to activation of transcription by NF-kappaB." [PMID:10390516] synonym: "endoplasmic reticulum overload response" EXACT [] synonym: "EOR" EXACT [] synonym: "ER-overload response" EXACT [] is_a: GO:0006984 ! ER-nucleus signaling pathway is_a: GO:0034976 ! response to endoplasmic reticulum stress is_a: GO:0071216 ! cellular response to biotic stimulus [Term] id: GO:0006984 name: ER-nucleus signaling pathway namespace: biological_process def: "Any series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation." [GOC:mah] synonym: "endoplasmic reticulum to nucleus signaling pathway" EXACT [] synonym: "endoplasmic reticulum-nuclear signaling pathway" EXACT [] synonym: "ER to nucleus signaling pathway" EXACT [] synonym: "ER to nucleus signalling pathway" EXACT [] synonym: "ER-nuclear signaling pathway" EXACT [] synonym: "ER-nuclear signalling pathway" EXACT [] is_a: GO:0023034 ! intracellular signaling pathway [Term] id: GO:0006985 name: positive regulation of NF-kappaB transcription factor activity by ER overload response namespace: biological_process def: "The conversion of inactive NF-kappaB to the active form, thereby allowing it to activate transcription of target genes, as a result of signaling from the endoplasmic reticulum." [GOC:dph, GOC:mah, GOC:tb, PMID:10390516] synonym: "EOR-mediated activation of NF-kappaB " EXACT [GOC:dph, GOC:tb] synonym: "EOR-mediated NF-kappaB activation" EXACT [] synonym: "positive regulation of NF-kappaB transcription factor activity by EOR" EXACT [GOC:dph, GOC:tb] is_a: GO:0051092 ! positive regulation of NF-kappaB transcription factor activity relationship: part_of GO:0006983 ! ER overload response [Term] id: GO:0006986 name: response to unfolded protein namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an unfolded protein stimulus." [GOC:jl] comment: Note that this term should not be confused with 'unfolded protein response ; GO:0030968', which refers to one specific response to the presence of unfolded proteins in the ER. subset: gosubset_prok synonym: "heat shock protein activity" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051789 ! response to protein stimulus [Term] id: GO:0006987 name: activation of signaling protein activity involved in unfolded protein response namespace: biological_process def: "The conversion of a specific protein, possessing protein kinase and endoribonuclease activities, to an active form as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] synonym: "unfolded protein response, activation of signaling protein activity" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of signaling protein kinase/endonuclease" EXACT [] synonym: "unfolded protein response, activation of signalling protein kinase/endonuclease" EXACT [] is_a: GO:0032075 ! positive regulation of nuclease activity is_a: GO:0045860 ! positive regulation of protein kinase activity relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006988 name: unfolded protein response, cleavage of primary transcript encoding UFP-specific transcription factor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0004521 consider: GO:0030969 [Term] id: GO:0006989 name: unfolded protein response, ligation of mRNA encoding UFP-specific transcription factor by RNA ligase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0008452 consider: GO:0030969 [Term] id: GO:0006990 name: positive regulation of gene-specific transcription involved in unfolded protein response namespace: biological_process def: "The activation of genes whose promoters contain a specific sequence elements such as the unfolded protein response element (UPRE; consensus CAGCGTG) or the ER stress-response element (ERSE; CCAAN(N)9CCACG), as a result of signaling via the unfolded protein response." [GOC:dph, GOC:mah, GOC:tb, PMID:12042763] synonym: "positive regulation of transcription of target genes involved in unfolded protein response" EXACT [GOC:dph, GOC:tb] synonym: "unfolded protein response, activation of target gene transcription" NARROW [] synonym: "unfolded protein response, positive regulation of target gene transcription" EXACT [GOC:tb] synonym: "unfolded protein response, stimulation of target gene transcription" NARROW [] synonym: "unfolded protein response, target gene transcriptional activation" BROAD [] synonym: "unfolded protein response, up regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, up-regulation of target gene transcription" EXACT [] synonym: "unfolded protein response, upregulation of target gene transcription" EXACT [] is_a: GO:0043193 ! positive regulation of gene-specific transcription is_a: GO:0045944 ! positive regulation of transcription from RNA polymerase II promoter relationship: part_of GO:0030968 ! endoplasmic reticulum unfolded protein response [Term] id: GO:0006991 name: response to sterol depletion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule." [GOC:bf, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "sterol depletion response" EXACT [GOC:dph, GOC:tb] is_a: GO:0006950 ! response to stress [Term] id: GO:0006992 name: sterol regulatory element binding protein cleavage involved in ER-nuclear sterol response pathway namespace: biological_process def: "The proteolytic release of a transcriptionally active sterol regulatory element binding protein (SREBP) from intracellular membranes, freeing it to move to the nucleus and upregulate transcription of target genes, in response to depleted sterol levels." [GOC:bf, PMID:12923525] synonym: "sterol depletion response, SREBP cleavage" EXACT [] is_a: GO:0035103 ! sterol regulatory element binding protein cleavage relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006993 name: sterol regulatory element binding protein nuclear translocation involved in sterol depletion response namespace: biological_process def: "The transfer of a sterol regulatory element binding protein (SREBP) into the nucleus across the nuclear membrane, in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] synonym: "sterol depletion response, SREBP nuclear translocation" EXACT [] synonym: "sterol depletion response, sterol regulatory element binding protein nuclear translocation" EXACT [GOC:dph, GOC:tb] is_a: GO:0035105 ! sterol regulatory element binding protein nuclear translocation relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006994 name: positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway namespace: biological_process def: "The process by which a sterol regulatory element binding protein (SREBP) mediates an increase in rate or extent of transcription of nuclear target genes in response to sterol depletion. SREBPs are transcription factors that bind sterol regulatory elements (SREs), DNA motifs found in the promoters of target genes." [GOC:bf, PMID:12923525] synonym: "positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response" EXACT [GOC:dph, GOC:tb] synonym: "sterol depletion response, SREBP target gene transcriptional activation" EXACT [GOC:dph, GOC:mtg_lung] is_a: GO:0035104 ! positive regulation of transcription via sterol regulatory element binding relationship: part_of GO:0030967 ! ER-nuclear sterol response pathway [Term] id: GO:0006995 name: cellular response to nitrogen starvation namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nitrogen." [GOC:jl] subset: gosubset_prok is_a: GO:0009267 ! cellular response to starvation is_a: GO:0043562 ! cellular response to nitrogen levels [Term] id: GO:0006996 name: organelle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an organelle within a cell. An organelle is an organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane." [GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "organelle organisation" EXACT [GOC:curators] synonym: "organelle organization and biogenesis" RELATED [GOC:dph, GOC:jl, GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0016043 ! cellular component organization [Term] id: GO:0006997 name: nucleus organization namespace: biological_process alt_id: GO:0048287 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleus." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_pir subset: goslim_yeast synonym: "nuclear morphology" RELATED [] synonym: "nuclear organisation" EXACT [GOC:curators] synonym: "nuclear organization" EXACT [GOC:curators] synonym: "nuclear organization and biogenesis" RELATED [GOC:mah] synonym: "nucleus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0006998 name: nuclear envelope organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear envelope." [GOC:dph, GOC:ems, GOC:jl, GOC:mah] synonym: "nuclear envelope organisation" EXACT [GOC:mah] synonym: "nuclear envelope organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0006997 ! nucleus organization [Term] id: GO:0006999 name: nuclear pore organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nuclear pore." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nuclear pore complex organization and biogenesis" RELATED [GOC:mah] synonym: "nuclear pore organisation" EXACT [GOC:curators] synonym: "nuclear pore organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization is_a: GO:0034621 ! cellular macromolecular complex subunit organization [Term] id: GO:0007000 name: nucleolus organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly the nucleolus." [GOC:dph, GOC:jid, GOC:jl, GOC:mah] synonym: "nucleolus organisation" EXACT [GOC:curators] synonym: "nucleolus organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006997 ! nucleus organization [Term] id: GO:0007002 name: centromere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0019237 [Term] id: GO:0007003 name: telomere binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a molecular function and not a biological process. is_obsolete: true replaced_by: GO:0042162 [Term] id: GO:0007004 name: telomere maintenance via telomerase namespace: biological_process def: "The maintenance of proper telomeric length by the addition of telomeric repeats by telomerase." [GOC:elh] synonym: "telomerase-dependent telomere maintenance" EXACT [] xref: Reactome:163090 "Elongation Of The Telomeric Chromosome End" xref: Reactome:163096 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:163099 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:163120 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:164616 "Biogenesis And Assembly Of The Telomerase RNP" xref: Reactome:164617 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:164620 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:171319 "Telomere Extension By Telomerase" xref: Reactome:541473 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:548039 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:548971 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:548992 "Elongation Of The Telomeric Chromosome End" xref: Reactome:559753 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:561812 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:562855 "Telomere Extension By Telomerase" xref: Reactome:568238 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:575020 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:575748 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:575774 "Elongation Of The Telomeric Chromosome End" xref: Reactome:585512 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:587432 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:588475 "Telomere Extension By Telomerase" xref: Reactome:593100 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:598470 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:599020 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:599046 "Elongation Of The Telomeric Chromosome End" xref: Reactome:606752 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:608415 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:609216 "Telomere Extension By Telomerase" xref: Reactome:615076 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:621807 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:622410 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:622413 "Elongation Of The Telomeric Chromosome End" xref: Reactome:631055 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:632925 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:633909 "Telomere Extension By Telomerase" xref: Reactome:657238 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:658596 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:658744 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:658745 "Elongation Of The Telomeric Chromosome End" xref: Reactome:660356 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:660724 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:661045 "Telomere Extension By Telomerase" xref: Reactome:662575 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:664236 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:664415 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:664425 "Elongation Of The Telomeric Chromosome End" xref: Reactome:666136 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:666492 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:666821 "Telomere Extension By Telomerase" xref: Reactome:668444 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:670190 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:670356 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:670366 "Elongation Of The Telomeric Chromosome End" xref: Reactome:672148 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:672550 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:672932 "Telomere Extension By Telomerase" xref: Reactome:674418 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:676214 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:676403 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:676413 "Elongation Of The Telomeric Chromosome End" xref: Reactome:677951 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:678335 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:678645 "Telomere Extension By Telomerase" xref: Reactome:679967 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:681331 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:681468 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:681478 "Elongation Of The Telomeric Chromosome End" xref: Reactome:682939 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:683249 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:683578 "Telomere Extension By Telomerase" xref: Reactome:685303 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:687016 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:687169 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:687170 "Elongation Of The Telomeric Chromosome End" xref: Reactome:689004 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:689412 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:689814 "Telomere Extension By Telomerase" xref: Reactome:692978 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:696864 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:697160 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:697163 "Elongation Of The Telomeric Chromosome End" xref: Reactome:700190 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:700914 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:701529 "Telomere Extension By Telomerase" xref: Reactome:705374 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:710417 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:710820 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:710823 "Elongation Of The Telomeric Chromosome End" xref: Reactome:714605 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:715452 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:716113 "Telomere Extension By Telomerase" xref: Reactome:722641 "Alignment Of The RNA Template On The Telomeric Chromosome End" xref: Reactome:724688 "Disassociation of Telomerase RNP and the Chromosome End" xref: Reactome:724883 "Elongation of Extended Telomeric Chromosome End" xref: Reactome:724893 "Elongation Of The Telomeric Chromosome End" xref: Reactome:727164 "Recruitment of Telomerase RNP to the Telomeric Chromosome End" xref: Reactome:727685 "Translocation Of Telomerase RNP And Alignment Of RNA Template (TERC) To Extended Single Stranded Telomeric Chromosome-End" xref: Reactome:728077 "Telomere Extension By Telomerase" is_a: GO:0006278 ! RNA-dependent DNA replication is_a: GO:0010833 ! telomere maintenance via telomere lengthening [Term] id: GO:0007005 name: mitochondrion organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrion; includes mitochondrial morphogenesis and distribution, and replication of the mitochondrial genome as well as synthesis of new mitochondrial components." [GOC:dph, GOC:jl, GOC:mah, GOC:sgd_curators, PMID:9786946] subset: goslim_generic subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "mitochondria organization" EXACT [GOC:mah] synonym: "mitochondrion organisation" EXACT [GOC:mah] synonym: "mitochondrion organization and biogenesis" RELATED [GOC:curators] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007006 name: mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a mitochondrial membrane, either of the lipid bilayer surrounding a mitochondrion." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007005 ! mitochondrion organization is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0007007 name: inner mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial inner membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial inner membrane ; GO:0005743'. synonym: "inner mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "inner mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] synonym: "mitochondrial inner membrane organization" EXACT [GOC:curators] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007008 name: outer mitochondrial membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial outer membrane." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] comment: See also the cellular component term 'mitochondrial outer membrane ; GO:0005741'. synonym: "outer mitochondrial membrane organisation" EXACT [GOC:curators] synonym: "outer mitochondrial membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007006 ! mitochondrial membrane organization [Term] id: GO:0007009 name: plasma membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the plasma membrane." [GOC:dph, GOC:jl, GOC:mah] subset: gosubset_prok synonym: "plasma membrane organisation" EXACT [GOC:curators] synonym: "plasma membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0007010 name: cytoskeleton organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_candida subset: goslim_generic subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "cytoskeletal organization and biogenesis" RELATED [GOC:mah] synonym: "cytoskeletal regulator activity" RELATED [] synonym: "cytoskeleton organisation" EXACT [GOC:curators] synonym: "cytoskeleton organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007011 name: regulation of cytoskeleton namespace: biological_process def: "OBSOLETE. Any process that modulates the frequency, rate or extent of the organization, biogenesis or maintenance of the cytoskeleton." [GOC:go_curators] comment: This term was made obsolete because cytoskeleton is neither a process nor a trait, so the term made no sense. is_obsolete: true consider: GO:0007010 [Term] id: GO:0007014 name: indirect flight muscle actin ubiquitination namespace: biological_process is_a: GO:0016567 ! protein ubiquitination is_a: GO:0030047 ! actin modification [Term] id: GO:0007015 name: actin filament organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments. Includes processes that control the spatial distribution of actin filaments, such as organizing filaments into meshworks, bundles, or other structures, as by cross-linking." [GOC:mah] synonym: "actin filament organisation" EXACT [GOC:curators] synonym: "regulation of actin filament localization" NARROW [] is_a: GO:0030036 ! actin cytoskeleton organization [Term] id: GO:0007016 name: cytoskeletal anchoring at plasma membrane namespace: biological_process def: "Process by which cytoskeletal filaments are directly or indirectly linked to the plasma membrane." [ISBN:0198599323] synonym: "cytoskeletal anchoring activity" RELATED [] is_a: GO:0007010 ! cytoskeleton organization is_a: GO:0032507 ! maintenance of protein location in cell [Term] id: GO:0007017 name: microtubule-based process namespace: biological_process def: "Any cellular process that depends upon or alters the microtubule cytoskeleton, that part of the cytoskeleton comprising microtubules and their associated proteins." [GOC:mah] is_a: GO:0009987 ! cellular process [Term] id: GO:0007018 name: microtubule-based movement namespace: biological_process def: "Movement of organelles, other microtubules and other particles along microtubules, mediated by motor proteins." [ISBN:0815316194] xref: Reactome:177479 "Axonal transport of NGF:Trk complexes" xref: Reactome:543579 "Axonal transport of NGF:Trk complexes" xref: Reactome:570717 "Axonal transport of NGF:Trk complexes" xref: Reactome:594948 "Axonal transport of NGF:Trk complexes" xref: Reactome:617481 "Axonal transport of NGF:Trk complexes" is_a: GO:0007017 ! microtubule-based process [Term] id: GO:0007019 name: microtubule depolymerization namespace: biological_process def: "The removal of tubulin heterodimers from one or both ends of a microtubule." [ISBN:0815316194] synonym: "microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "microtubule depolymerization during nuclear congression" NARROW [] synonym: "microtubule disassembly" EXACT [] is_a: GO:0031109 ! microtubule polymerization or depolymerization is_a: GO:0051261 ! protein depolymerization [Term] id: GO:0007020 name: microtubule nucleation namespace: biological_process def: "The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell." [ISBN:0815316194] xref: Wikipedia:Microtubule_nucleation is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0007021 name: tubulin complex assembly namespace: biological_process def: "The aggregation and bonding together of alpha- and beta-tubulin to form a tubulin heterodimer." [GOC:mah] synonym: "tubulin assembly" EXACT [] synonym: "tubulin folding" RELATED [] synonym: "tubulin-specific chaperone activity" RELATED [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0007023 name: post-chaperonin tubulin folding pathway namespace: biological_process def: "Completion of folding of alpha- and beta-tubulin; takes place subsequent to chaperonin-mediated partial folding; mediated by a complex of folding cofactors." [PMID:10542094] xref: Reactome:389977 "Post-chaperonin tubulin folding pathway" xref: Reactome:391548 "Post-chaperonin tubulin folding pathway" xref: Reactome:562864 "Post-chaperonin tubulin folding pathway" xref: Reactome:588485 "Post-chaperonin tubulin folding pathway" xref: Reactome:609225 "Post-chaperonin tubulin folding pathway" xref: Reactome:633918 "Post-chaperonin tubulin folding pathway" xref: Reactome:645490 "Post-chaperonin tubulin folding pathway" xref: Reactome:655851 "Post-chaperonin tubulin folding pathway" xref: Reactome:661051 "Post-chaperonin tubulin folding pathway" xref: Reactome:666826 "Post-chaperonin tubulin folding pathway" xref: Reactome:672937 "Post-chaperonin tubulin folding pathway" xref: Reactome:678652 "Post-chaperonin tubulin folding pathway" xref: Reactome:683584 "Post-chaperonin tubulin folding pathway" xref: Reactome:689820 "Post-chaperonin tubulin folding pathway" xref: Reactome:701535 "Post-chaperonin tubulin folding pathway" xref: Reactome:716119 "Post-chaperonin tubulin folding pathway" xref: Reactome:728081 "Post-chaperonin tubulin folding pathway" xref: Reactome:730984 "Post-chaperonin tubulin folding pathway" is_a: GO:0006457 ! protein folding [Term] id: GO:0007026 name: negative regulation of microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of microtubule depolymerization; prevention of depolymerization of a microtubule can result from binding by 'capping' at the plus end (e.g. by interaction with another cellular protein of structure) or by exposing microtubules to a stabilizing drug such as taxol." [GOC:mah, ISBN:0815316194] synonym: "down regulation of microtubule depolymerization" EXACT [] synonym: "down-regulation of microtubule depolymerization" EXACT [] synonym: "downregulation of microtubule depolymerization" EXACT [] synonym: "inhibition of microtubule depolymerization" NARROW [] synonym: "microtubule rescue" NARROW [GOC:dph, GOC:tb] synonym: "microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule catastrophe" NARROW [GOC:dph, GOC:tb] synonym: "negative regulation of microtubule disassembly" EXACT [] is_a: GO:0031111 ! negative regulation of microtubule polymerization or depolymerization is_a: GO:0031114 ! regulation of microtubule depolymerization is_a: GO:0043242 ! negative regulation of protein complex disassembly intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007019 ! microtubule depolymerization relationship: negatively_regulates GO:0007019 ! microtubule depolymerization [Term] id: GO:0007027 name: negative regulation of axonemal microtubule depolymerization namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the depolymerization of the specialized microtubules of the axoneme." [GOC:dph, GOC:mah] synonym: "axonemal microtubule stabilization" EXACT [] synonym: "negative regulation of microtubule depolymerization in axoneme" RELATED [GOC:dph] is_a: GO:0007026 ! negative regulation of microtubule depolymerization intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization relationship: negatively_regulates GO:0060404 ! axonemal microtubule depolymerization [Term] id: GO:0007028 name: cytoplasm organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cytoplasm. The cytoplasm is all of the contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures." [GOC:curators, GOC:dph, GOC:jl, GOC:mah] subset: goslim_generic subset: goslim_pir subset: gosubset_prok synonym: "cytoplasm organisation" EXACT [GOC:curators] synonym: "cytoplasm organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009987 ! cellular process is_a: GO:0016043 ! cellular component organization [Term] id: GO:0007029 name: endoplasmic reticulum organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endoplasmic reticulum morphology" RELATED [] synonym: "endoplasmic reticulum organisation" EXACT [GOC:curators] synonym: "endoplasmic reticulum organization and biogenesis" RELATED [GOC:mah] synonym: "ER organisation" EXACT [GOC:curators] synonym: "ER organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007030 name: Golgi organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the Golgi apparatus." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "Golgi organisation" EXACT [GOC:curators] synonym: "Golgi organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007031 name: peroxisome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a peroxisome. A peroxisome is a small, membrane-bounded organelle that uses dioxygen (O2) to oxidize organic molecules." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "peroxisome organisation" EXACT [GOC:curators] synonym: "peroxisome organization and biogenesis" RELATED [GOC:mah] synonym: "peroxisome-assembly ATPase activity" RELATED [] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007032 name: endosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of endosomes." [GOC:dph, GOC:jl, GOC:mah] subset: goslim_pir synonym: "endosome organisation" EXACT [GOC:curators] synonym: "endosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007033 name: vacuole organization namespace: biological_process alt_id: GO:0044086 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a vacuole." [GOC:mah] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast synonym: "vacuolar assembly" NARROW [GOC:mah] synonym: "vacuole biogenesis" RELATED [GOC:mah] synonym: "vacuole organisation" EXACT [GOC:curators] synonym: "vacuole organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0007034 name: vacuolar transport namespace: biological_process def: "The directed movement of substances into, out of or within a vacuole." [GOC:ai] is_a: GO:0046907 ! intracellular transport [Term] id: GO:0007035 name: vacuolar acidification namespace: biological_process def: "Any process that reduces the pH of the vacuole, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction [Term] id: GO:0007036 name: vacuolar calcium ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of calcium ions in the vacuole or between a vacuole and its surroundings." [GOC:ai, GOC:mah] is_a: GO:0006874 ! cellular calcium ion homeostasis [Term] id: GO:0007037 name: vacuolar phosphate transport namespace: biological_process def: "The directed movement of phosphates into, out of or within a vacuole." [GOC:ai] is_a: GO:0006817 ! phosphate transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007038 name: endocytosed protein transport to vacuole namespace: biological_process def: "The directed movement of proteins imported into a cell by endocytosis to the vacuole." [GOC:ai] comment: See also the biological process term 'endocytosis ; GO:0006897'. synonym: "delivery of endocytosed proteins to the vacuole" EXACT [] is_a: GO:0006886 ! intracellular protein transport is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007039 name: vacuolar protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein in the vacuole, usually by the action of vacuolar proteases." [GOC:mah] synonym: "vacuolar protein breakdown" EXACT [] synonym: "vacuolar protein catabolism" EXACT [] synonym: "vacuolar protein degradation" EXACT [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0007040 name: lysosome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosome. A lysosome is a cytoplasmic, membrane-bounded organelle that is found in most animal cells and that contains a variety of hydrolases." [GOC:mah] synonym: "lysosome organisation" EXACT [GOC:curators] synonym: "lysosome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0007033 ! vacuole organization [Term] id: GO:0007041 name: lysosomal transport namespace: biological_process def: "The directed movement of substances into, out of or within a lysosome." [GOC:ai] is_a: GO:0007034 ! vacuolar transport [Term] id: GO:0007042 name: lysosomal lumen acidification namespace: biological_process def: "Any process that reduces the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion." [GOC:jid] is_a: GO:0051452 ! intracellular pH reduction relationship: part_of GO:0007040 ! lysosome organization [Term] id: GO:0007043 name: cell-cell junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between cells." [GOC:ai] synonym: "intercellular junction assembly" EXACT [] is_a: GO:0034329 ! cell junction assembly is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0007044 name: cell-substrate junction assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate." [GOC:mah] is_a: GO:0034329 ! cell junction assembly [Term] id: GO:0007045 name: cell-substrate adherens junction assembly namespace: biological_process def: "The aggregation, arrangement, and bonding together of a set of components to form a cell-substrate adherens junction." [GOC:mah] synonym: "hemi-adherens junction assembly" RELATED [GOC:mah] is_a: GO:0007044 ! cell-substrate junction assembly [Term] id: GO:0007047 name: cellular cell wall organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis." [GOC:dph, GOC:jl, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "cell wall organization at cellular level" EXACT [GOC:mah] synonym: "cellular cell wall organisation" EXACT [GOC:curators] is_a: GO:0045229 ! external encapsulating structure organization is_a: GO:0070882 ! cellular cell wall organization or biogenesis is_a: GO:0071555 ! cell wall organization [Term] id: GO:0007048 name: oncogenesis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a pathological process. is_obsolete: true [Term] id: GO:0007049 name: cell cycle namespace: biological_process def: "The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division." [GOC:go_curators] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "cell-division cycle" EXACT [] xref: Wikipedia:Cell_cycle is_a: GO:0009987 ! cellular process [Term] id: GO:0007050 name: cell cycle arrest namespace: biological_process def: "The process by which the cell cycle is halted during one of the normal phases (G1, S, G2, M)." [GOC:dph, GOC:mah, GOC:tb] synonym: "arrest of cell cycle progression" EXACT [] synonym: "cessation of cell cycle" EXACT [] synonym: "termination of cell cycle" EXACT [] xref: Reactome:380972 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:562764 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:588381 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:609120 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:633816 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:645409 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:655777 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:661058 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:666832 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:672944 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:678659 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:683590 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:689826 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:701541 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:716125 "Energy dependent regulation of mTOR by LKB1-AMPK" xref: Reactome:728087 "Energy dependent regulation of mTOR by LKB1-AMPK" is_a: GO:0022402 ! cell cycle process is_a: GO:0045786 ! negative regulation of cell cycle [Term] id: GO:0007051 name: spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart." [GOC:mah] synonym: "spindle organisation" EXACT [GOC:curators] synonym: "spindle organization and biogenesis" RELATED [GOC:mah] is_a: GO:0000226 ! microtubule cytoskeleton organization relationship: part_of GO:0000279 ! M phase [Term] id: GO:0007052 name: mitotic spindle organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle." [GOC:mah] synonym: "mitotic spindle organisation" EXACT [GOC:curators] synonym: "mitotic spindle organization and biogenesis" RELATED [GOC:mah] synonym: "spindle organization and biogenesis during mitosis" EXACT [] is_a: GO:0007051 ! spindle organization is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007053 name: spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007054 name: spindle assembly involved in male meiosis I namespace: biological_process def: "The formation of the spindle during meiosis I of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis I spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007141 ! male meiosis I [Term] id: GO:0007055 name: spindle assembly involved male meiosis II namespace: biological_process def: "The formation of the spindle during meiosis II of a meiotic cell cycle in males. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "male meiosis II spindle assembly" RELATED [] is_a: GO:0007053 ! spindle assembly involved in male meiosis relationship: part_of GO:0007142 ! male meiosis II [Term] id: GO:0007056 name: spindle assembly involved in female meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiotic spindle assembly" RELATED [] is_a: GO:0090306 ! spindle assembly involved in meiosis relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007057 name: spindle assembly involved in female meiosis I namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis I of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis I spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007144 ! female meiosis I [Term] id: GO:0007058 name: spindle assembly involved in female meiosis II namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the spindle during meiosis II of a meiotic cell cycle in females. An example of this is found in Drosophila melanogaster." [GOC:mah] synonym: "female meiosis II spindle assembly" RELATED [] is_a: GO:0007056 ! spindle assembly involved in female meiosis relationship: part_of GO:0007147 ! female meiosis II [Term] id: GO:0007059 name: chromosome segregation namespace: biological_process def: "The process by which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets." [GOC:ai] subset: goslim_pir subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "chromosome division" EXACT [] synonym: "chromosome transmission" RELATED [] xref: Wikipedia:Chromosome_segregation is_a: GO:0009987 ! cellular process [Term] id: GO:0007060 name: male meiosis chromosome segregation namespace: biological_process def: "The cell cycle process whereby genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during the meiotic cell cycle in a male." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0045132 ! meiotic chromosome segregation relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007062 name: sister chromatid cohesion namespace: biological_process def: "The cell cycle process by which the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome." [GOC:mah, ISBN:0815316194] xref: Reactome:163048 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:558913 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:584572 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:606122 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:630389 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:643631 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:654137 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:660160 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:665902 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:671997 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:677804 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:682810 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:688837 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:720024 "Phosphorylation of the SA2 Cohesion Complex" xref: Reactome:726967 "Phosphorylation of the SA2 Cohesion Complex" is_a: GO:0022402 ! cell cycle process is_a: GO:0051276 ! chromosome organization relationship: part_of GO:0007059 ! chromosome segregation [Term] id: GO:0007063 name: regulation of sister chromatid cohesion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of sister chromatid cohesion." [GOC:go_curators] is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0033044 ! regulation of chromosome organization is_a: GO:0051983 ! regulation of chromosome segregation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007062 ! sister chromatid cohesion relationship: regulates GO:0007062 ! sister chromatid cohesion [Term] id: GO:0007064 name: mitotic sister chromatid cohesion namespace: biological_process def: "The cell cycle process whereby the sister chromatids of a replicated chromosome are joined along the entire length of the chromosome, from their formation in S phase through metaphase during a mitotic cell cycle. This cohesion cycle is critical for high fidelity chromosome transmission." [GOC:ai, GOC:rn, PMID:10827941, PMID:11389843, PMID:14623866] is_a: GO:0007062 ! sister chromatid cohesion relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007065 name: male meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a male." [GOC:ai] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007066 name: female meiosis sister chromatid cohesion namespace: biological_process def: "The joining of the sister chromatids of a replicated chromosome along the entire length of the chromosome that occurs during meiosis in a female." [GOC:ai] is_a: GO:0051177 ! meiotic sister chromatid cohesion relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007067 name: mitosis namespace: biological_process def: "A cell cycle process comprising the steps by which the nucleus of a eukaryotic cell divides; the process involves condensation of chromosomal DNA into a highly compacted form. Canonically, mitosis produces two daughter nuclei whose chromosome complement is identical to that of the mother cell." [GOC:dph, GOC:ma, GOC:mah, ISBN:0198547684] xref: Wikipedia:Mitosis is_a: GO:0000280 ! nuclear division is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0007068 name: negative regulation of transcription, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription during mitosis." [GOC:go_curators] synonym: "down regulation of transcription, mitotic" EXACT [] synonym: "down-regulation of transcription, mitotic" EXACT [] synonym: "downregulation of transcription, mitotic" EXACT [] synonym: "inhibition of transcription, mitotic" NARROW [] synonym: "mitotic repression of transcription" EXACT [] synonym: "negative regulation of transcription during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0045892 ! negative regulation of transcription, DNA-dependent is_a: GO:0045896 ! regulation of transcription, mitotic [Term] id: GO:0007069 name: negative regulation of transcription from RNA polymerase I promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase I promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase I promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase I promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol I promoter" EXACT [] synonym: "negative regulation of transcription from Pol I promoter, mitotic" EXACT [] synonym: "negative regulation of transcription from RNA polymerase I promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0007068 ! negative regulation of transcription, mitotic is_a: GO:0016479 ! negative regulation of transcription from RNA polymerase I promoter is_a: GO:0046017 ! regulation of transcription from RNA polymerase I promoter, mitotic [Term] id: GO:0007070 name: negative regulation of transcription from RNA polymerase II promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase II promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase II promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase II promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol II promoter" EXACT [] synonym: "negative regulation of transcription from Pol II promoter, mitotic" EXACT [] synonym: "negative regulation of transcription from RNA polymerase II promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0000122 ! negative regulation of transcription from RNA polymerase II promoter is_a: GO:0007068 ! negative regulation of transcription, mitotic is_a: GO:0046021 ! regulation of transcription from RNA polymerase II promoter, mitotic [Term] id: GO:0007071 name: negative regulation of transcription from RNA polymerase III promoter, mitotic namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of transcription from an RNA polymerase III promoter during mitosis." [GOC:go_curators] synonym: "down regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "down-regulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "downregulation of transcription from RNA polymerase III promoter, mitotic" EXACT [] synonym: "inhibition of transcription from RNA polymerase III promoter, mitotic" NARROW [] synonym: "mitotic repression of transcription from Pol III promoter" EXACT [] synonym: "negative regulation of transcription from Pol III promoter, mitotic" EXACT [] synonym: "negative regulation of transcription from RNA polymerase III promoter during mitosis" EXACT [GOC:dph, GOC:tb] is_a: GO:0007068 ! negative regulation of transcription, mitotic is_a: GO:0016480 ! negative regulation of transcription from RNA polymerase III promoter is_a: GO:0046023 ! regulation of transcription from RNA polymerase III promoter, mitotic [Term] id: GO:0007072 name: positive regulation of transcription on exit from mitosis namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "activation of transcription on exit from mitosis" NARROW [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process is_a: GO:0045941 ! positive regulation of transcription relationship: part_of GO:0010458 ! exit from mitosis [Term] id: GO:0007073 name: positive regulation of transcription on exit from mitosis, from RNA polymerase I promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase I promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol I promoter" NARROW [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from RNA polymerase I promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007074 name: positive regulation of transcription on exit from mitosis, from RNA polymerase II promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol II promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase II promoter" NARROW [] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007075 name: positive regulation of transcription on exit from mitosis, from RNA polymerase III promoter namespace: biological_process def: "Any process that increases the frequency, rate or extent of transcription from an RNA polymerase III promoter as the cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] synonym: "activation of transcription on exit from mitosis, from Pol III promoter" NARROW [] synonym: "activation of transcription on exit from mitosis, from RNA polymerase III promoter" NARROW [GOC:dph, GOC:tb] is_a: GO:0007072 ! positive regulation of transcription on exit from mitosis [Term] id: GO:0007076 name: mitotic chromosome condensation namespace: biological_process def: "The cell cycle process whereby chromatin structure is compacted prior to and during mitosis in eukaryotic cells." [GOC:mah, ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007077 name: mitotic nuclear envelope disassembly namespace: biological_process def: "The cell cycle process whereby the controlled breakdown of the nuclear envelope during mitotic cell division occurs." [GOC:bf] synonym: "mitotic nuclear envelope breakdown" EXACT [] synonym: "mitotic nuclear envelope catabolism" EXACT [] synonym: "mitotic nuclear envelope degradation" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051081 ! nuclear envelope disassembly relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007078 name: lamin depolymerization namespace: biological_process def: "The cell cycle process whereby lamin is depolymerized." [GOC:jid] is_a: GO:0022402 ! cell cycle process is_a: GO:0051261 ! protein depolymerization relationship: part_of GO:0007077 ! mitotic nuclear envelope disassembly [Term] id: GO:0007079 name: mitotic chromosome movement towards spindle pole namespace: biological_process alt_id: GO:0007082 def: "The cell cycle process whereby the directed movement of chromosomes from the center of the spindle towards the spindle poles occurs. This mediates by the shortening of microtubules attached to the chromosomes, during mitosis." [GOC:ai] synonym: "chromosome migration to spindle pole during mitosis" EXACT [] synonym: "chromosome movement towards spindle pole during mitosis" EXACT [] synonym: "mitotic chromosome movement" BROAD [] synonym: "mitotic chromosome movement to spindle pole" EXACT [] synonym: "mitotic sister chromosome movement towards spindle pole" EXACT [] synonym: "sister chromosome movement towards spindle pole during mitosis" EXACT [] is_a: GO:0022402 ! cell cycle process is_a: GO:0051305 ! chromosome movement towards spindle pole relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007080 name: mitotic metaphase plate congression namespace: biological_process def: "The cell cycle process whereby chromosomes are aligned at the metaphase plate, a plane halfway between the poles of the mitotic spindle, during mitosis." [GOC:mah, ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0051310 ! metaphase plate congression relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007081 name: mitotic sister-chromatid adhesion release namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous and appears to encompass two processes. is_obsolete: true consider: GO:0000070 consider: GO:0007064 [Term] id: GO:0007083 name: mitotic chromosome decondensation namespace: biological_process def: "The cell cycle process whereby chromosome structure is altered from the condensed form taken on during mitosis to the relaxed disperse form held in resting cells." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051312 ! chromosome decondensation relationship: part_of GO:0000070 ! mitotic sister chromatid segregation [Term] id: GO:0007084 name: mitotic nuclear envelope reassembly namespace: biological_process def: "The cell cycle process whereby the nuclear envelope reforms during mitotic cell division." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0031468 ! nuclear envelope reassembly relationship: part_of GO:0000278 ! mitotic cell cycle [Term] id: GO:0007085 name: nuclear membrane vesicle binding to chromatin namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0003682 [Term] id: GO:0007086 name: vesicle fusion with nuclear membrane namespace: biological_process def: "The cell cycle process whereby the joining of the lipid bilayer membrane around a vesicle with the lipid bilayer membrane around the nucleus occurs." [GOC:jid] is_a: GO:0006906 ! vesicle fusion is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007087 name: mitotic nuclear pore complex reassembly namespace: biological_process def: "The cell cycle process whereby nuclear pore complexes reform during mitotic cell division." [GOC:ai] is_a: GO:0022402 ! cell cycle process is_a: GO:0051292 ! nuclear pore complex assembly relationship: part_of GO:0007084 ! mitotic nuclear envelope reassembly [Term] id: GO:0007088 name: regulation of mitosis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mitosis." [GOC:go_curators] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process is_a: GO:0051783 ! regulation of nuclear division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007067 ! mitosis relationship: regulates GO:0007067 ! mitosis [Term] id: GO:0007089 name: traversing start control point of mitotic cell cycle namespace: biological_process alt_id: GO:0000081 def: "Passage through a cell cycle control point late in G1 phase of the mitotic cell cycle just before entry into S phase; in most organisms studied, including budding yeast and animal cells, passage through start normally commits the cell to progressing through the entire cell cycle." [GOC:mah, ISBN:0815316194] synonym: "G1 checkpoint" RELATED [] is_a: GO:0007346 ! regulation of mitotic cell cycle relationship: part_of GO:0000080 ! G1 phase of mitotic cell cycle [Term] id: GO:0007090 name: regulation of S phase of mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the frequency, rate or extent of the progression through the S phase of the mitotic cell cycle." [GOC:go_curators] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0033261 ! regulation of S phase intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000084 ! S phase of mitotic cell cycle relationship: regulates GO:0000084 ! S phase of mitotic cell cycle [Term] id: GO:0007091 name: mitotic metaphase/anaphase transition namespace: biological_process def: "The cell cycle process whereby a cell progresses from metaphase to anaphase during mitosis, triggered by the destruction of mitotic cyclins." [PMID:10465783] xref: Reactome:563142 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:588753 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:609480 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:634185 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:645842 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:656162 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:661304 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:667082 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:673231 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:678915 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:683845 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:68881 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:690097 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:720921 "Mitotic Metaphase/Anaphase Transition" xref: Reactome:728369 "Mitotic Metaphase/Anaphase Transition" is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0007092 name: activation of mitotic anaphase-promoting complex activity namespace: biological_process def: "Any process that initiates the ubiquitin ligase activity of the anaphase-promoting complex that regulates the mitotic metaphase/anaphase transition." [GOC:dph, GOC:mah, GOC:tb, PMID:10871297] synonym: "activation of ubiquitin ligase activity of anaphase promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of anaphase-promoting complex during mitotic cell cycle" EXACT [] synonym: "activation of ubiquitin ligase activity of APC during mitotic cell cycle" EXACT [] synonym: "anaphase promoting complex activation during mitotic cell cycle" EXACT [] synonym: "anaphase-promoting complex activation during mitotic cell cycle" EXACT [] synonym: "APC activation during mitotic cell cycle" EXACT [] synonym: "mitotic anaphase promoting complex activation" EXACT [] synonym: "mitotic anaphase promoting complex activator" NARROW [] synonym: "mitotic anaphase-promoting complex activation" EXACT [] synonym: "mitotic anaphase-promoting complex activator" NARROW [] synonym: "mitotic APC activation" EXACT [] synonym: "mitotic APC activator" NARROW [] xref: Reactome:162659 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:163010 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:540715 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:548695 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:567456 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:575487 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:592398 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:598813 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:614293 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:622196 "Down Regulation of Emi1 through Phosphorylation of Emi1" xref: Reactome:636296 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:647680 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:657055 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:662362 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:668231 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:674184 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:685057 "Activation of the Anaphase Promoting Complex (APC) by Plk1" xref: Reactome:722393 "Activation of the Anaphase Promoting Complex (APC) by Plk1" is_a: GO:0032436 ! positive regulation of proteasomal ubiquitin-dependent protein catabolic process is_a: GO:0045842 ! positive regulation of mitotic metaphase/anaphase transition is_a: GO:0051437 ! positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle is_a: GO:0051488 ! activation of anaphase-promoting complex activity relationship: positively_regulates GO:0031145 ! anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process relationship: positively_regulates GO:0090302 ! mitotic anaphase-promoting complex activity [Term] id: GO:0007093 name: mitotic cell cycle checkpoint namespace: biological_process def: "A signal transduction-based surveillance mechanism that ensures accurate chromosome replication and segregation by preventing progression through a mitotic cell cycle until conditions are suitable for the cell to proceed to the next stage." [GOC:mah, GOC:rn, PMID:12360190] synonym: "mitotic checkpoint" RELATED [] synonym: "regulation of mitotic cell cycle by cell cycle checkpoint" EXACT [GOC:dph, GOC:tb] is_a: GO:0000075 ! cell cycle checkpoint is_a: GO:0007165 ! signal transduction is_a: GO:0007346 ! regulation of mitotic cell cycle [Term] id: GO:0007094 name: mitotic cell cycle spindle assembly checkpoint namespace: biological_process def: "A signal transduction based surveillance mechanism that ensures the fidelity of cell division by preventing the premature advance of cells from metaphase to anaphase prior to the successful attachment of kinetochores to spindle microtubules (spindle assembly)." [GOC:rn, PMID:12360190] synonym: "Mad2-dependent checkpoint" NARROW [] synonym: "negative regulation of mitotic metaphase/anaphase transition by spindle assembly checkpoint" EXACT [GOC:dph, GOC:tb] xref: Reactome:562998 "Mitotic Spindle Checkpoint" xref: Reactome:588614 "Mitotic Spindle Checkpoint" xref: Reactome:609356 "Mitotic Spindle Checkpoint" xref: Reactome:634049 "Mitotic Spindle Checkpoint" xref: Reactome:645580 "Mitotic Spindle Checkpoint" xref: Reactome:661256 "Mitotic Spindle Checkpoint" xref: Reactome:667029 "Mitotic Spindle Checkpoint" xref: Reactome:673177 "Mitotic Spindle Checkpoint" xref: Reactome:678712 "Mitotic Spindle Checkpoint" xref: Reactome:683646 "Mitotic Spindle Checkpoint" xref: Reactome:690003 "Mitotic Spindle Checkpoint" xref: Reactome:69618 "Mitotic Spindle Checkpoint" xref: Reactome:701618 "Mitotic Spindle Checkpoint" xref: Reactome:716202 "Mitotic Spindle Checkpoint" xref: Reactome:728151 "Mitotic Spindle Checkpoint" is_a: GO:0045841 ! negative regulation of mitotic metaphase/anaphase transition is_a: GO:0071173 ! spindle assembly checkpoint is_a: GO:0071174 ! mitotic cell cycle spindle checkpoint [Term] id: GO:0007095 name: mitotic cell cycle G2/M transition DNA damage checkpoint namespace: biological_process def: "A signal transduction-based surveillance mechanism that acts during a mitotic cell cycle to ensure accurate chromosome segregation by preventing entry into mitosis in the presence of damaged DNA." [GOC:mah, PMID:10856933, PMID:11406266] synonym: "mitotic G2 checkpoint" RELATED [] is_a: GO:0007093 ! mitotic cell cycle checkpoint is_a: GO:0031572 ! G2/M transition DNA damage checkpoint [Term] id: GO:0007096 name: regulation of exit from mitosis namespace: biological_process def: "Any process involved in the progression from anaphase/telophase to G1 that is associated with a conversion from high to low mitotic CDK activity." [GOC:rn] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010458 ! exit from mitosis relationship: regulates GO:0010458 ! exit from mitosis [Term] id: GO:0007097 name: nuclear migration namespace: biological_process def: "The directed movement of the nucleus." [GOC:ai] synonym: "nucleus migration" EXACT [] is_a: GO:0040023 ! establishment of nucleus localization [Term] id: GO:0007098 name: centrosome cycle namespace: biological_process def: "The cell cycle process whereby centrosome duplication and separation takes place. The centrosome cycle can operate with a considerable degree of independence from other processes of the cell cycle." [ISBN:0815316194] is_a: GO:0022402 ! cell cycle process is_a: GO:0051297 ! centrosome organization [Term] id: GO:0007099 name: centriole replication namespace: biological_process def: "The cell cycle process whereby a daughter centriole is formed perpendicular to an existing centriole. An immature centriole contains a ninefold radially symmetric array of single microtubules; mature centrioles consist of a radial array of nine microtubule triplets, doublets, or singlets depending upon the species and cell type." [GOC:kmv, ISBN:0815316194] synonym: "centriole duplication" EXACT [] is_a: GO:0007017 ! microtubule-based process is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0051298 ! centrosome duplication [Term] id: GO:0007100 name: mitotic centrosome separation namespace: biological_process def: "Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle." [ISBN:0815316194] is_a: GO:0051299 ! centrosome separation relationship: part_of GO:0007067 ! mitosis [Term] id: GO:0007101 name: male meiosis centrosome cycle namespace: biological_process def: "Centrosome duplication and separation in the context of male meiosis." [GOC:mah] synonym: "centrosome cycle involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0007098 ! centrosome cycle relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0007103 name: spindle pole body duplication in nuclear envelope namespace: biological_process def: "Construction of a new spindle pole body adjacent to the existing spindle pole body in the nuclear envelope; usually occurs about the time of bud emergence. An example of this is found in Saccharomyces cerevisiae." [ISBN:0879693649] is_a: GO:0030474 ! spindle pole body duplication [Term] id: GO:0007105 name: cytokinesis, site selection namespace: biological_process def: "The process of marking the place where cytokinesis will occur." [GOC:clt, GOC:dph, GOC:tb] subset: gosubset_prok synonym: "actomyosin ring positioning" NARROW [] synonym: "contractile ring positioning" NARROW [] synonym: "site selection involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007106 name: cytokinesis, protein recruitment namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it was not defined. is_obsolete: true [Term] id: GO:0007107 name: membrane addition at site of cytokinesis namespace: biological_process def: "Any process involved in the net addition of membrane at the site of cytokinesis; includes vesicle recruitment and fusion, local lipid synthesis and insertion." [GOC:clt] synonym: "cytokinesis, membrane recruitment/generation" EXACT [] is_a: GO:0016044 ! cellular membrane organization is_a: GO:0032506 ! cytokinetic process [Term] id: GO:0007108 name: cytokinesis, initiation of separation namespace: biological_process def: "The process involved in starting cell separation." [GOC:clt, GOC:dph, GOC:tb] synonym: "initiation of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0007109 name: cytokinesis, completion of separation namespace: biological_process def: "The process of finishing cell separation, which results in two physically separated cells." [GOC:clt, GOC:dph, GOC:tb] synonym: "completion of separation involved in cytokinesis" EXACT [GOC:dph, GOC:tb] is_a: GO:0032506 ! cytokinetic process relationship: part_of GO:0000920 ! cytokinetic cell separation [Term] id: GO:0007110 name: cytokinesis after meiosis I namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis I, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007111 name: cytokinesis after meiosis II namespace: biological_process def: "A cell cycle process that results in the division of the cytoplasm of a cell after meiosis II, resulting in the separation of the original cell into two daughter cells." [GOC:ai] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007112 name: male meiosis cytokinesis namespace: biological_process def: "A cell cycle process that occurs as part of the male meiotic cell cycle and results in the division of the cytoplasm of a cell to produce two daughter cells." [GOC:ai] synonym: "cytokinesis after male meiosis" EXACT [GOC:dph, GOC:tb] synonym: "cytokinesis involved in male meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0033206 ! cytokinesis after meiosis [Term] id: GO:0007113 name: endomitotic cell cycle namespace: biological_process def: "A mitotic cell cycle in which chromosomes are replicated and sister chromatids separate, but spindle formation, nuclear membrane breakdown and nuclear division do not occur, resulting in an increased number of chromosomes in the cell." [GOC:curators, GOC:dos, GOC:expert_vm] synonym: "endomitosis" EXACT [] xref: Wikipedia:Mitosis#Endomitosis is_a: GO:0000278 ! mitotic cell cycle [Term] id: GO:0007114 name: cell budding namespace: biological_process def: "A form of asexual reproduction, occurring in certain bacteria and fungi (e.g. yeasts) and some primitive animals in which an individual arises from a daughter cell formed by pinching off a part of the parent cell. The budlike outgrowths so formed may sometimes remain attached to the parent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_candida subset: goslim_yeast subset: gosubset_prok synonym: "budding" BROAD [] is_a: GO:0019954 ! asexual reproduction is_a: GO:0032505 ! reproduction of a single-celled organism is_a: GO:0051301 ! cell division [Term] id: GO:0007115 name: bud site selection/establishment of cell polarity (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents two processes. is_obsolete: true consider: GO:0000282 consider: GO:0030010 [Term] id: GO:0007116 name: regulation of cell budding namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the formation and growth of cell buds." [GOC:mah] synonym: "regulation of budding" BROAD [] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007114 ! cell budding relationship: regulates GO:0007114 ! cell budding [Term] id: GO:0007117 name: budding cell bud growth namespace: biological_process def: "The process by which the bud portion of a cell that reproduces by budding irreversibly increases in size over time by accretion and biosynthetic production of matter similar to that already present." [GOC:go_curators] synonym: "bud growth" BROAD [] is_a: GO:0040007 ! growth relationship: part_of GO:0007114 ! cell budding [Term] id: GO:0007118 name: budding cell apical bud growth namespace: biological_process def: "Growth at the tip of a bud, in a cell that reproduces by budding." [GOC:go_curators] synonym: "apical bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007119 name: budding cell isotropic bud growth namespace: biological_process def: "Unlocalized bud growth such that the entire surface of the bud expands evenly, in a cell that reproduces by budding." [GOC:go_curators] synonym: "isotropic bud growth" BROAD [] is_a: GO:0007117 ! budding cell bud growth [Term] id: GO:0007120 name: axial cellular bud site selection namespace: biological_process def: "The process of defining the next site of bud emergence adjacent to the last site of bud emergence on a budding cell." [GOC:clt] synonym: "axial bud site selection" EXACT [] synonym: "axial budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007121 name: bipolar cellular bud site selection namespace: biological_process def: "The process of defining subsequent sites of bud emergence such that budding takes place at alternating poles of a budding cell." [GOC:clt] synonym: "bipolar bud site selection" EXACT [] synonym: "bipolar budding" BROAD [] synonym: "polar budding" BROAD [] is_a: GO:0000282 ! cellular bud site selection is_a: GO:0007114 ! cell budding [Term] id: GO:0007122 name: loss of asymmetric budding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. is_obsolete: true consider: GO:0006033 [Term] id: GO:0007123 name: bud scar accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a phenotype rather than a biological process. is_obsolete: true consider: GO:0000282 [Term] id: GO:0007124 name: pseudohyphal growth namespace: biological_process def: "A pattern of cell growth that occurs in conditions of nitrogen limitation and abundant fermentable carbon source. Cells become elongated, switch to a unipolar budding pattern, remain physically attached to each other, and invade the growth substrate." [GOC:krc, PMID:11104818] subset: goslim_candida subset: goslim_yeast is_a: GO:0016049 ! cell growth is_a: GO:0070783 ! growth of unicellular organism as a thread of attached cells [Term] id: GO:0007125 name: invasive growth namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it has been split into two new terms. is_obsolete: true consider: GO:0001403 consider: GO:0044409 [Term] id: GO:0007126 name: meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle, the specialized nuclear and cell division in which a single diploid cell undergoes two nuclear divisions following a single round of DNA replication in order to produce four daughter cells that contain half the number of chromosomes as the diploid cell. Meiotic division occurs during the formation of gametes from diploid organisms and at the beginning of haplophase in those organisms that alternate between diploid and haploid generations." [GOC:dph, GOC:mah, PMID:9334324] subset: goslim_pombe subset: goslim_yeast xref: Wikipedia:Meiosis is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0051327 ! M phase of meiotic cell cycle [Term] id: GO:0007127 name: meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the first phase of meiosis, in which cells divide and homologous chromosomes are paired and segregated from each other, producing two daughter cells." [GOC:dph, GOC:mah, PMID:9334324] xref: Wikipedia:Meiosis#Meiosis_I is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0007128 name: meiotic prophase I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prophase of meiosis I; divided into several stages." [GOC:dph, GOC:mah] is_a: GO:0051324 ! prophase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007129 name: synapsis namespace: biological_process def: "The cell cycle process whereby the side by side pairing and physical juxtaposition of homologous chromosomes is created at the metaphase plate." [GOC:elh] synonym: "chromosomal pairing" RELATED [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "chromosomal synapsis" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "homologous chromosome pairing at meiosis" EXACT [] xref: Wikipedia:Synapsis is_a: GO:0070192 ! chromosome organization involved in meiosis relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007130 name: synaptonemal complex assembly namespace: biological_process def: "The cell cycle process whereby the synaptonemal complex is formed. This is a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "synaptonemal complex formation" EXACT [] is_a: GO:0022607 ! cellular component assembly is_a: GO:0070192 ! chromosome organization involved in meiosis is_a: GO:0070193 ! synaptonemal complex organization relationship: part_of GO:0007129 ! synapsis [Term] id: GO:0007131 name: reciprocal meiotic recombination namespace: biological_process alt_id: GO:0000021 alt_id: GO:0007145 def: "The cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate. This results in the equal exchange of genetic material between non-sister chromatids in a pair of homologous chromosomes. These reciprocal recombinant products ensure the proper segregation of homologous chromosomes during meiosis I and create genetic diversity." [PMID:2087779] synonym: "female meiotic recombination" NARROW [] synonym: "gene conversion with reciprocal crossover" EXACT [] is_a: GO:0006310 ! DNA recombination is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007132 name: meiotic metaphase I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through metaphase of meiosis I; analogous to mitotic metaphase." [GOC:dph, GOC:mah] is_a: GO:0051323 ! metaphase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007133 name: meiotic anaphase I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase of meiosis I; analogous to mitotic anaphase." [GOC:dph, GOC:mah] is_a: GO:0051322 ! anaphase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007134 name: meiotic telophase I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through telophase of meiosis I; analogous to mitotic telophase." [GOC:dph, GOC:mah] is_a: GO:0051326 ! telophase relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0007135 name: meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the second phase of meiosis, in which cells divide and separate the two chromatids in each chromosome." [GOC:dph, GOC:mah, ISBN:0198547684] xref: Wikipedia:Meiosis#Meiosis_II is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007126 ! meiosis [Term] id: GO:0007136 name: meiotic prophase II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through prophase of meiosis II; analogous to mitotic prophase." [GOC:dph, GOC:mah] is_a: GO:0051324 ! prophase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007137 name: meiotic metaphase II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through metaphase of meiosis II; analogous to mitotic metaphase." [GOC:dph, GOC:mah] is_a: GO:0051323 ! metaphase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007138 name: meiotic anaphase II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through anaphase of meiosis II; analogous to mitotic anaphase." [GOC:dph, GOC:mah] is_a: GO:0051322 ! anaphase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007139 name: meiotic telophase II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through telophase of meiosis II; analogous to mitotic telophase." [GOC:dph, GOC:mah] is_a: GO:0051326 ! telophase relationship: part_of GO:0007135 ! meiosis II [Term] id: GO:0007140 name: male meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the male germline." [GOC:dph, GOC:mah] is_a: GO:0007126 ! meiosis [Term] id: GO:0007141 name: male meiosis I namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis I, the first meiotic division in the male germline." [GOC:dph, GOC:mah] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007142 name: male meiosis II namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through male meiosis II, the second meiotic division in the male germline." [GOC:dph, GOC:mah] is_a: GO:0022403 ! cell cycle phase relationship: part_of GO:0007140 ! male meiosis [Term] id: GO:0007143 name: female meiosis namespace: biological_process def: "A cell cycle process comprising the steps by which a cell progresses through the nuclear division phase of a meiotic cell cycle in the female germline." [GOC:dph, GOC:ems, GOC:mah] comment: Note that female germ lines can be found in female or hermaphroditic organisms, so this term can be used to annotate gene products from hermaphrodites such as those of C. elegans. See also the biological process term 'meiosis ; GO:0007126'. is_a: GO:0007126 ! meiosis [Term] id: GO:0007144 name: female meiosis I namespace: biological_process def: "The cell cycle process whereby the first meiotic division occurs in the female germline." [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007146 name: meiotic recombination nodule assembly namespace: biological_process def: "During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes." [GOC:jl, PMID:9334324] is_a: GO:0000707 ! meiotic DNA recombinase assembly [Term] id: GO:0007147 name: female meiosis II namespace: biological_process def: "The cell cycle process whereby the second meiotic division occurs in the female germline." [GOC:mah] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007143 ! female meiosis [Term] id: GO:0007149 name: colony morphology namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mcc] comment: This term was made obsolete because it describes a phenotype rather than a biological goal. is_obsolete: true [Term] id: GO:0007150 name: growth pattern namespace: biological_process def: "OBSOLETE. A process whereby cells develop a specific morphology under a specific set of circumstances." [GOC:jid] comment: This term was made obsolete because the original meaning of the term is unclear, the current definition is incorrect, and it does not describe a biological process. is_obsolete: true consider: GO:0040007 [Term] id: GO:0007154 name: cell communication namespace: biological_process def: "Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment." [GOC:mah] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Cell_signaling is_a: GO:0009987 ! cellular process [Term] id: GO:0007155 name: cell adhesion namespace: biological_process def: "The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules." [GOC:hb, GOC:pf] subset: goslim_candida subset: goslim_pir subset: goslim_pombe subset: gosubset_prok synonym: "cell adhesion molecule activity" RELATED [] xref: Wikipedia:Cell_adhesion is_a: GO:0009987 ! cellular process is_a: GO:0022610 ! biological adhesion [Term] id: GO:0007156 name: homophilic cell adhesion namespace: biological_process def: "The attachment of an adhesion molecule in one cell to an identical molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007157 name: heterophilic cell-cell adhesion namespace: biological_process def: "The attachment of an adhesion molecule in one cell to a nonidentical adhesion molecule in an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "agglutination" RELATED [GOC:mah] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007158 name: neuron cell-cell adhesion namespace: biological_process def: "The attachment of a neuron to another cell via adhesion molecules." [GOC:go_curators] synonym: "neuron adhesion" EXACT [GOC:curators] synonym: "neuronal cell adhesion" EXACT [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007159 name: leukocyte cell-cell adhesion namespace: biological_process def: "The attachment of a leukocyte to another cell via adhesion molecules." [GOC:go_curators] synonym: "leukocyte adhesion" EXACT [GOC:curators] synonym: "leukocyte cell adhesion" EXACT [] is_a: GO:0016337 ! cell-cell adhesion [Term] id: GO:0007160 name: cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules." [GOC:hb] subset: gosubset_prok is_a: GO:0031589 ! cell-substrate adhesion [Term] id: GO:0007161 name: calcium-independent cell-matrix adhesion namespace: biological_process def: "The binding of a cell to the extracellular matrix via adhesion molecules that do not require the presence of calcium for the interaction." [GOC:hb] synonym: "calcium-independent cell adhesion molecule activity" RELATED [] is_a: GO:0007160 ! cell-matrix adhesion [Term] id: GO:0007162 name: negative regulation of cell adhesion namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of cell adhesion." [GOC:go_curators] synonym: "cell adhesion receptor inhibitor activity" RELATED [] synonym: "down regulation of cell adhesion" EXACT [] synonym: "down-regulation of cell adhesion" EXACT [] synonym: "downregulation of cell adhesion" EXACT [] synonym: "inhibition of cell adhesion" NARROW [] is_a: GO:0030155 ! regulation of cell adhesion is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007155 ! cell adhesion relationship: negatively_regulates GO:0007155 ! cell adhesion [Term] id: GO:0007163 name: establishment or maintenance of cell polarity namespace: biological_process alt_id: GO:0030012 alt_id: GO:0030467 def: "Any cellular process that results in the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns." [GOC:mah] subset: goslim_pombe synonym: "establishment and/or maintenance of cell polarity" RELATED [] synonym: "establishment and/or maintenance of cell polarization" RELATED [] is_a: GO:0009987 ! cellular process [Term] id: GO:0007164 name: establishment of tissue polarity namespace: biological_process def: "Coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007165 name: signal transduction namespace: biological_process def: "The process whereby an activated receptor conveys information down the signaling pathway, resulting in a change in the function or state of a cell." [GOC:go_curators] comment: Note that in many cases the end of this process is the initiation of transcription. subset: goslim_candida subset: goslim_generic subset: goslim_plant subset: goslim_pombe subset: goslim_yeast subset: gosubset_prok synonym: "signaling cascade" EXACT [] synonym: "signalling cascade" EXACT [] xref: Reactome:212718 "EGFR interacts with phospholipase C-gamma" xref: Reactome:562812 "EGFR interacts with phospholipase C-gamma" xref: Reactome:588428 "EGFR interacts with phospholipase C-gamma" xref: Reactome:609170 "EGFR interacts with phospholipase C-gamma" xref: Reactome:633864 "EGFR interacts with phospholipase C-gamma" xref: Wikipedia:Signal_transduction is_a: GO:0023060 ! signal transmission is_a: GO:0050794 ! regulation of cellular process [Term] id: GO:0007166 name: cell surface receptor linked signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell." [GOC:mah] subset: gosubset_prok synonym: "cell surface receptor linked signal transduction" EXACT [] xref: Reactome:110437 "DILP binds to Drosophila insulin receptor (DINR)" is_a: GO:0023033 ! signaling pathway [Term] id: GO:0007167 name: enzyme linked receptor protein signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses catalytic activity or is closely associated with an enzyme such as a protein kinase." [GOC:mah, ISBN:0185316194] synonym: "enzyme linked receptor protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007168 name: receptor guanylyl cyclase signaling pathway namespace: biological_process def: "Any series of molecular signals initiated by the binding of an extracellular ligand to a receptor on the surface of the target cell, where the receptor possesses guanylyl cyclase activity." [GOC:mah] synonym: "receptor guanylyl cyclase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007169 name: transmembrane receptor protein tyrosine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:ceb] synonym: "transmembrane receptor protein tyrosine kinase signalling pathway" EXACT [] xref: Reactome:187015 "Activation of TRKA receptors" xref: Reactome:562715 "Activation of TRKA receptors" xref: Reactome:588335 "Activation of TRKA receptors" xref: Reactome:609078 "Activation of TRKA receptors" xref: Reactome:633773 "Activation of TRKA receptors" is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007170 name: transmembrane receptor protein tyrosine kinase ligand binding namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a function rather than a process. is_obsolete: true consider: GO:0030971 [Term] id: GO:0007171 name: activation of transmembrane receptor protein tyrosine kinase activity namespace: biological_process def: "Any process that initiates the activity of the inactive transmembrane receptor protein tyrosine kinase activity." [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase activation" RELATED [GOC:dph, GOC:tb] synonym: "transmembrane receptor protein tyrosine kinase dimerization" RELATED [GOC:dph, GOC:mtg_lung] is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007172 name: signal complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a complex capable of relaying a signal within a cell. Complex formation involves dimerization of a receptor protein tyrosine kinase followed by the association of several different intracellular signaling molecules with the cytoplasmic tails of the receptors." [PMID:9646862] synonym: "signal complex formation" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007173 name: epidermal growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "EGF receptor signaling pathway" EXACT [] synonym: "EGF receptor signalling pathway" EXACT [] synonym: "EGFR signaling pathway" EXACT [] synonym: "epidermal growth factor receptor signalling pathway" EXACT [] xref: Reactome:177929 "Signaling by EGFR" xref: Reactome:562703 "Signaling by EGFR" xref: Reactome:588324 "Signaling by EGFR" xref: Reactome:609068 "Signaling by EGFR" xref: Reactome:633761 "Signaling by EGFR" xref: Reactome:645371 "Signaling by EGFR" xref: Reactome:655739 "Signaling by EGFR" xref: Reactome:661185 "Signaling by EGFR" xref: Reactome:666963 "Signaling by EGFR" xref: Reactome:673098 "Signaling by EGFR" xref: Reactome:678798 "Signaling by EGFR" xref: Reactome:683726 "Signaling by EGFR" xref: Reactome:689943 "Signaling by EGFR" xref: Reactome:701718 "Signaling by EGFR" xref: Reactome:716295 "Signaling by EGFR" xref: Reactome:728238 "Signaling by EGFR" xref: Reactome:731074 "Signaling by EGFR" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0007174 name: epidermal growth factor ligand processing namespace: biological_process def: "The proteolysis of epidermal growth factor after its internalization via binding to its receptor." [GOC:isa_complete, PMID:2985587] synonym: "EGF receptor ligand processing" EXACT [] is_a: GO:0051605 ! protein maturation by peptide bond cleavage relationship: part_of GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0007175 name: negative regulation of epidermal growth factor receptor activity namespace: biological_process alt_id: GO:0007177 def: "Any process that stops, prevents or reduces the frequency, rate or extent of EGF receptor activity." [GOC:go_curators] synonym: "down regulation of epidermal growth factor receptor activity" EXACT [] synonym: "down-regulation of epidermal growth factor receptor activity" EXACT [] synonym: "downregulation of epidermal growth factor receptor activity" EXACT [] synonym: "EGF receptor downregulation" EXACT [] synonym: "inhibition of epidermal growth factor receptor activity" NARROW [] synonym: "negative regulation of EGF receptor activity" EXACT [] synonym: "negative regulation of EGFR activity" EXACT [] is_a: GO:0007176 ! regulation of epidermal growth factor receptor activity is_a: GO:0042059 ! negative regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061099 ! negative regulation of protein tyrosine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0005006 ! epidermal growth factor receptor activity relationship: negatively_regulates GO:0005006 ! epidermal growth factor receptor activity [Term] id: GO:0007176 name: regulation of epidermal growth factor receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of EGF receptor activity." [GOC:dph, GOC:go_curators] synonym: "regulation of EGF receptor activity" EXACT [] synonym: "regulation of EGFR activity" EXACT [] is_a: GO:0010469 ! regulation of receptor activity is_a: GO:0042058 ! regulation of epidermal growth factor receptor signaling pathway is_a: GO:0061097 ! regulation of protein tyrosine kinase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005006 ! epidermal growth factor receptor activity relationship: regulates GO:0005006 ! epidermal growth factor receptor activity [Term] id: GO:0007178 name: transmembrane receptor protein serine/threonine kinase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand." [GOC:mah] synonym: "transmembrane receptor protein serine/threonine kinase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007179 name: transforming growth factor beta receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transforming growth factor beta receptor binding to one of its physiological ligands." [GOC:mah] synonym: "TGF-beta receptor signaling pathway" EXACT [] synonym: "TGF-beta receptor signalling pathway" EXACT [] synonym: "TGFbeta receptor signaling pathway" EXACT [] synonym: "TGFbeta receptor signalling pathway" EXACT [] synonym: "transforming growth factor beta receptor signalling pathway" EXACT [] xref: Reactome:170834 "Signaling by TGF beta" xref: Reactome:562716 "Signaling by TGF beta" xref: Reactome:588336 "Signaling by TGF beta" xref: Reactome:609079 "Signaling by TGF beta" xref: Reactome:633774 "Signaling by TGF beta" xref: Reactome:645826 "Signaling by TGF beta" is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007180 name: transforming growth factor beta ligand binding to type II receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type II receptor" EXACT [] synonym: "TGFbeta ligand binding to type II receptor" EXACT [] is_obsolete: true consider: GO:0005026 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0007181 name: transforming growth factor beta receptor complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a ligand-bound type II transforming growth factor beta (TGF-beta) receptor dimer with a type I TGF-beta receptor dimer, following ligand binding, to form a heterotetrameric TGF-beta receptor complex." [GOC:jl, Reactome:REACT_7425, Wikipedia:TGF_beta_signaling_pathway] synonym: "TGF-beta receptor complex assembly" EXACT [] synonym: "TGF-beta:type II receptor:type I receptor complex assembly" EXACT [] synonym: "TGFbeta receptor complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007179 ! transforming growth factor beta receptor signaling pathway [Term] id: GO:0007182 name: common-partner SMAD protein phosphorylation namespace: biological_process def: "The process of introducing a phosphate group on to a common-partner SMAD protein. A common partner SMAD protein binds to pathway-restricted SMAD proteins forming a complex that translocates to the nucleus." [GOC:dph, ISBN:3527303782] synonym: "common mediator SMAD protein phosphorylation" EXACT [] is_a: GO:0006468 ! protein amino acid phosphorylation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007183 name: SMAD protein complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a protein complex that contains SMAD proteins." [GOC:isa_complete] synonym: "SMAD protein heteromerization" NARROW [GOC:mah, PMID:9670020] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007184 name: SMAD protein nuclear translocation namespace: biological_process def: "The vectorial transfer of a SMAD proteins from the cytoplasm into the nucleus, through the nuclear pore. Pathway-restricted SMAD proteins and common-partner SMAD proteins are involved in the transforming growth factor beta receptor signaling pathways." [GOC:dph] synonym: "SMAD protein import into nucleus, translocation" EXACT [GOC:dph, GOC:tb] is_a: GO:0000060 ! protein import into nucleus, translocation relationship: part_of GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0007185 name: transmembrane receptor protein tyrosine phosphatase signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a transmembrane receptor tyrosine phosphatase binding to its physiological ligand." [GOC:mah] synonym: "transmembrane receptor protein tyrosine phosphatase signalling pathway" EXACT [] is_a: GO:0007167 ! enzyme linked receptor protein signaling pathway [Term] id: GO:0007186 name: G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] synonym: "G protein coupled receptor protein signaling pathway" EXACT [] synonym: "G protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein coupled receptor protein signal transduction" EXACT [] synonym: "G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "GPCR protein signaling pathway" EXACT [] synonym: "GPCR protein signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007187 name: G-protein signaling, coupled to cyclic nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic nucleotide second messenger" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0019935 ! cyclic-nucleotide-mediated signaling [Term] id: GO:0007188 name: G-protein signaling, coupled to cAMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by modulation of adenylyl cyclase activity and a subsequent change in the concentration of cyclic AMP." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signaling, coupled to cyclic AMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cAMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cyclic AMP nucleotide second messenger" EXACT [] is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger is_a: GO:0019933 ! cAMP-mediated signaling [Term] id: GO:0007189 name: activation of adenylate cyclase activity by G-protein signaling pathway namespace: biological_process alt_id: GO:0010580 def: "Any process that initiates the activity of an inactive adenylate cyclase that is an integral part of the series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, resulting in a subsequent change in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "activation of adenylate cyclase activity involved in G-protein signaling" EXACT [] synonym: "G protein signaling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase activating pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase activating pathway" EXACT [] xref: Reactome:170660 "Adenylate cyclase activating pathway" xref: Reactome:562822 "Adenylate cyclase activating pathway" xref: Reactome:588438 "Adenylate cyclase activating pathway" xref: Reactome:609180 "Adenylate cyclase activating pathway" xref: Reactome:633874 "Adenylate cyclase activating pathway" xref: Reactome:645456 "Adenylate cyclase activating pathway" xref: Reactome:655819 "Adenylate cyclase activating pathway" is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger is_a: GO:0007190 ! activation of adenylate cyclase activity is_a: GO:0010579 ! positive regulation of adenylate cyclase activity by G-protein signaling pathway [Term] id: GO:0007190 name: activation of adenylate cyclase activity namespace: biological_process def: "Any process that initiates the activity of the inactive enzyme adenylate cyclase." [GOC:ai] synonym: "adenylate cyclase activation" EXACT [GOC:dph, GOC:tb] synonym: "adenylate cyclase activator" RELATED [] synonym: "adenylyl cyclase activation" EXACT [] xref: Reactome:170672 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:187024 "NGF-independant TRKA activation" xref: Reactome:551088 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:563003 "NGF-independant TRKA activation" xref: Reactome:577682 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:588620 "NGF-independant TRKA activation" xref: Reactome:600547 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:609359 "NGF-independant TRKA activation" xref: Reactome:624104 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:634054 "NGF-independant TRKA activation" xref: Reactome:640931 "Galpha-olf:GTP binds to adenylate cyclase and activates it" xref: Reactome:651505 "Galpha-olf:GTP binds to adenylate cyclase and activates it" is_a: GO:0045762 ! positive regulation of adenylate cyclase activity [Term] id: GO:0007191 name: activation of adenylate cyclase activity by dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:mah] synonym: "activation of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] synonym: "dopamine receptor, adenylate cyclase activating pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway is_a: GO:0023050 ! consequence of signal transmission [Term] id: GO:0007192 name: activation of adenylate cyclase activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by activation of adenylyl cyclase and a subsequent increase in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, adenylate cyclase activating pathway" RELATED [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase activating pathway" EXACT [] is_a: GO:0007189 ! activation of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007193 name: inhibition of adenylate cyclase activity by G-protein signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "G protein signaling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signaling, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signaling, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylate cyclase inhibiting pathway" EXACT [] synonym: "G-protein signalling, adenylyl cyclase inhibiting pathway" EXACT [] xref: Reactome:170670 "Adenylate cyclase inhibitory pathway" xref: Reactome:562826 "Adenylate cyclase inhibitory pathway" xref: Reactome:588442 "Adenylate cyclase inhibitory pathway" xref: Reactome:609184 "Adenylate cyclase inhibitory pathway" xref: Reactome:633878 "Adenylate cyclase inhibitory pathway" xref: Reactome:645461 "Adenylate cyclase inhibitory pathway" xref: Reactome:655824 "Adenylate cyclase inhibitory pathway" xref: Reactome:690010 "Adenylate cyclase inhibitory pathway" xref: Reactome:716353 "Adenylate cyclase inhibitory pathway" xref: Reactome:728293 "Adenylate cyclase inhibitory pathway" is_a: GO:0007188 ! G-protein signaling, coupled to cAMP nucleotide second messenger is_a: GO:0007194 ! negative regulation of adenylate cyclase activity [Term] id: GO:0007194 name: negative regulation of adenylate cyclase activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of adenylate cyclase activity." [GOC:go_curators] synonym: "adenylate cyclase inhibitor" RELATED [] synonym: "down regulation of adenylate cyclase activity" EXACT [] synonym: "down-regulation of adenylate cyclase activity" EXACT [] synonym: "downregulation of adenylate cyclase activity" EXACT [] synonym: "inhibition of adenylate cyclase activity" NARROW [] synonym: "negative regulation of adenylyl cyclase activity" EXACT [] is_a: GO:0031280 ! negative regulation of cyclase activity is_a: GO:0045761 ! regulation of adenylate cyclase activity is_a: GO:0051350 ! negative regulation of lyase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004016 ! adenylate cyclase activity relationship: negatively_regulates GO:0004016 ! adenylate cyclase activity [Term] id: GO:0007195 name: inhibition of adenylate cyclase activity by dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "dopamine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "dopamine receptor, adenylyl cyclase inhibiting pathway" EXACT [] synonym: "inhibition of adenylate cyclase activity by dopamine receptor signalling pathway" EXACT [GOC:mah] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007212 ! dopamine receptor signaling pathway is_a: GO:0023050 ! consequence of signal transmission [Term] id: GO:0007196 name: inhibition of adenylate cyclase activity by metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "metabotropic glutamate receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway [Term] id: GO:0007197 name: inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "muscarinic acetylcholine receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway [Term] id: GO:0007198 name: inhibition of adenylate cyclase activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by inhibition of adenylyl cyclase and a subsequent decrease in the concentration of cyclic AMP." [GOC:dph, GOC:mah, GOC:tb] synonym: "inhibition of adenylate cyclase activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, adenylate cyclase inhibiting pathway" EXACT [GOC:dph, GOC:tb] synonym: "serotonin receptor, adenylyl cyclase inhibiting pathway" EXACT [] is_a: GO:0007193 ! inhibition of adenylate cyclase activity by G-protein signaling pathway is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007199 name: G-protein signaling, coupled to cGMP nucleotide second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by activation of guanylyl cyclase and a subsequent increase in the concentration of cyclic GMP." [GOC:mah, ISBN:0815316194] synonym: "G protein signaling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] synonym: "G-protein signalling, coupled to cGMP nucleotide second messenger" EXACT [] is_a: GO:0007187 ! G-protein signaling, coupled to cyclic nucleotide second messenger is_a: GO:0019934 ! cGMP-mediated signaling [Term] id: GO:0007200 name: activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger namespace: biological_process def: "The series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb, ISBN:0815316194] synonym: "G protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "G-protein signaling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [GOC:dph, GOC:tb] synonym: "G-protein signalling, coupled to IP3 second messenger (phospholipase C activating)" EXACT [] synonym: "phospholipase C-activating dopamine receptor signaling pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0007202 ! activation of phospholipase C activity is_a: GO:0048015 ! phosphoinositide-mediated signaling [Term] id: GO:0007201 name: G-protein dissociation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because the dissociation of heterotrimeric G protein subunits is a consequence of a conformational change, which is in turn a consequence of ligand binding; it does not require multiple activities specifically to bring about. is_obsolete: true [Term] id: GO:0007202 name: activation of phospholipase C activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme phospolipase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:dph, GOC:mah, GOC:tb, PMID:8280098] comment: Note that this term refers to a signaling pathway, and should not be confused with function terms such as 'phospholipase activator activity ; GO:0016004'. synonym: "phospholipase C activation" EXACT [GOC:dph, GOC:tb] xref: Reactome:167021 "PLC-gamma1 signalling" xref: Reactome:562813 "PLC-gamma1 signalling" xref: Reactome:588429 "PLC-gamma1 signalling" xref: Reactome:609171 "PLC-gamma1 signalling" xref: Reactome:633865 "PLC-gamma1 signalling" xref: Reactome:645448 "PLC-gamma1 signalling" xref: Reactome:655811 "PLC-gamma1 signalling" xref: Reactome:661107 "PLC-gamma1 signalling" xref: Reactome:666885 "PLC-gamma1 signalling" xref: Reactome:673007 "PLC-gamma1 signalling" xref: Reactome:678728 "PLC-gamma1 signalling" xref: Reactome:683661 "PLC-gamma1 signalling" xref: Reactome:689777 "PLC-gamma1 signalling" xref: Reactome:701633 "PLC-gamma1 signalling" xref: Reactome:716089 "PLC-gamma1 signalling" xref: Reactome:720776 "PLC-gamma1 signalling" xref: Reactome:728056 "PLC-gamma1 signalling" xref: Reactome:730964 "PLC-gamma1 signalling" is_a: GO:0010863 ! positive regulation of phospholipase C activity [Term] id: GO:0007203 name: phosphatidylinositol-4,5-bisphosphate hydrolysis namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because hydrolysis is a reaction, not a process. is_obsolete: true consider: GO:0004435 [Term] id: GO:0007204 name: elevation of cytosolic calcium ion concentration namespace: biological_process def: "Any process that increases the concentration of calcium ions in the cytosol." [GOC:ai] synonym: "cytoplasmic calcium ion concentration elevation" BROAD [] synonym: "cytosolic calcium ion concentration elevation" EXACT [] synonym: "elevation of calcium ion concentration in cytoplasm" BROAD [] synonym: "elevation of calcium ion concentration in cytosol" EXACT [] synonym: "elevation of cytoplasmic calcium ion concentration" BROAD [] is_a: GO:0051480 ! cytosolic calcium ion homeostasis [Term] id: GO:0007205 name: activation of protein kinase C activity by G-protein coupled receptor protein signaling pathway namespace: biological_process def: "The initiation of the activity of the inactive enzyme protein kinase C as the result of a series of molecular signals generated as a consequence of a G-protein coupled receptor binding to its physiological ligand." [GOC:mah] synonym: "activation of protein kinase C activity by G-protein coupled receptor protein signalling pathway" EXACT [GOC:mah] synonym: "PKC activation" EXACT [] synonym: "protein kinase C activation" EXACT [GOC:dph, GOC:tb] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0032147 ! activation of protein kinase activity [Term] id: GO:0007206 name: activation of phospholipase C activity by metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a metabotropic glutamate receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by metabotropic glutamate receptor signalling pathway" EXACT [GOC:mah] synonym: "metabotropic glutamate receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007216 ! metabotropic glutamate receptor signaling pathway [Term] id: GO:0007207 name: activation of phospholipase C activity by muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by muscarinic acetylcholine receptor signalling pathway" EXACT [GOC:mah] synonym: "muscarinic acetylcholine receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007213 ! muscarinic acetylcholine receptor signaling pathway [Term] id: GO:0007208 name: activation of phospholipase C activity by serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by serotonin receptor signalling pathway" EXACT [GOC:mah] synonym: "serotonin receptor, phospholipase C activating pathway" EXACT [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007210 ! serotonin receptor signaling pathway [Term] id: GO:0007209 name: activation of phospholipase C activity by tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin receptor binding to its physiological ligand, followed by the activation of phospholipase C and the subsequent release of inositol trisphosphate." [GOC:dph, GOC:mah, GOC:tb] synonym: "activation of phospholipase C activity by tachykinin receptor signalling pathway" EXACT [GOC:mah] synonym: "tachykinin receptor, phospholipase C activating pathway" RELATED [GOC:dph, GOC:tb] is_a: GO:0007200 ! activation of phospholipase C activity by G-protein coupled receptor protein signaling pathway coupled to IP3 second messenger is_a: GO:0007217 ! tachykinin receptor signaling pathway [Term] id: GO:0007210 name: serotonin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a serotonin receptor binding to one of its physiological ligands." [GOC:mah] synonym: "serotonin receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007211 name: octopamine/tyramine signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an octopamine/tyramine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "octopamine/tyramine signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007212 name: dopamine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a dopamine receptor binding to one of its physiological ligands." [GOC:mah] synonym: "dopamine receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007213 name: muscarinic acetylcholine receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a muscarinic acetylcholine receptor binding to one of its physiological ligands; muscarinic acetylcholine receptors activate inhibitory G proteins and can be activated by the fungal alkaloid muscarine." [GOC:mah, ISBN:0815316194] synonym: "acetylcholine receptor signalling, muscarinic pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007214 name: gamma-aminobutyric acid signaling pathway namespace: biological_process def: "The series of molecular signals generated by the binding of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, to a cell surface receptor." [GOC:mah] synonym: "4-aminobutanoate signaling pathway" EXACT [] synonym: "4-aminobutanoate signalling pathway" EXACT [] synonym: "4-aminobutyrate signaling pathway" EXACT [] synonym: "4-aminobutyrate signalling pathway" EXACT [] synonym: "GABA signaling pathway" EXACT [] synonym: "GABA signalling pathway" EXACT [] synonym: "gamma-aminobutyric acid signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007215 name: glutamate signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor." [GOC:mah, PMID:9131252] synonym: "glutamate signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007216 name: metabotropic glutamate receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of glutamate binding to a cell surface receptor coupled to effectors through GTP-binding proteins." [GOC:mah, PMID:9131252] synonym: "metabotropic glutamate receptor signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway is_a: GO:0007215 ! glutamate signaling pathway [Term] id: GO:0007217 name: tachykinin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a tachykinin, i.e. a short peptide with the terminal sequence (Phe-X-Gly-Leu-Met-NH2), binding to a cell surface receptor." [GOC:mah, PMID:14723970] synonym: "tachykinin signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007218 name: neuropeptide signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a peptide neurotransmitter binding to a cell surface receptor." [GOC:mah, ISBN:0815316194] synonym: "neuropeptide signalling pathway" EXACT [] is_a: GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0007219 name: Notch signaling pathway namespace: biological_process alt_id: GO:0030179 def: "The series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell." [GOC:go_curators] synonym: "N signaling pathway" EXACT [] synonym: "N signalling pathway" EXACT [] synonym: "Notch receptor signaling pathway" EXACT [] synonym: "Notch receptor signalling pathway" EXACT [] synonym: "Notch signalling pathway" EXACT [] synonym: "Notch-receptor signaling pathway" EXACT [] synonym: "Notch-receptor signalling pathway" EXACT [] xref: Reactome:157118 "Signaling by Notch" xref: Reactome:563301 "Signaling by Notch" xref: Reactome:588918 "Signaling by Notch" xref: Reactome:609634 "Signaling by Notch" xref: Reactome:634332 "Signaling by Notch" xref: Reactome:645805 "Signaling by Notch" xref: Reactome:656132 "Signaling by Notch" xref: Reactome:690070 "Signaling by Notch" xref: Reactome:728341 "Signaling by Notch" xref: Reactome:731152 "Signaling by Notch" xref: Wikipedia:Notch_signaling_pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007220 name: Notch receptor processing namespace: biological_process def: "The series of successive proteolytic cleavages of the Notch protein, which result in an active form of the receptor." [PMID:12651094, PMID:14986688] synonym: "N receptor processing" EXACT [] xref: Reactome:156988 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:157212 "A third proteolytic cleavage releases NICD" xref: Reactome:563300 "A third proteolytic cleavage releases NICD" xref: Reactome:563308 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:588917 "A third proteolytic cleavage releases NICD" xref: Reactome:588925 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:609633 "A third proteolytic cleavage releases NICD" xref: Reactome:609641 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:634331 "A third proteolytic cleavage releases NICD" xref: Reactome:634340 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:645804 "A third proteolytic cleavage releases NICD" xref: Reactome:645811 "Receptor-ligand binding initiates the second proteolytic cleavage of Notch receptor" xref: Reactome:656131 "A third proteolytic cleavage releases NICD" xref: Reactome:728340 "A third proteolytic cleavage releases NICD" is_a: GO:0044267 ! cellular protein metabolic process [Term] id: GO:0007221 name: positive regulation of transcription of Notch receptor target namespace: biological_process def: "The activation of transcription of specific genes as a result of Notch signaling, mediated by the Notch intracellular domain." [PMID:12651094] synonym: "N receptor target transcription factor activation" RELATED [] synonym: "Notch receptor target transcription factor activation" RELATED [] is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter relationship: part_of GO:0007219 ! Notch signaling pathway [Term] id: GO:0007223 name: Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:bf, GOC:dph, GOC:go_curators, PMID:11532397] synonym: "frizzled-2 signaling pathway" NARROW [] synonym: "frizzled-2 signalling pathway" NARROW [] synonym: "non-canonical Wnt signaling pathway" RELATED [] is_a: GO:0035567 ! non-canonical Wnt receptor signaling pathway [Term] id: GO:0007224 name: smoothened signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened." [GOC:mah, PMID:15205520] synonym: "hedgehog signaling pathway" EXACT [] synonym: "hh signaling pathway" EXACT [] synonym: "hh signalling pathway" EXACT [] synonym: "smoothened signalling pathway" EXACT [] xref: Wikipedia:Hedgehog_signaling_pathway is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007225 name: patched ligand maturation namespace: biological_process def: "The posttranslational modification of members of the Hedgehog family of signaling proteins in order for Hedgehog to exert its biological activity. These modifications include cleavage of its signal sequence, autocatalytic protein cleavage and the attachment of sterol moieties." [PMID:15057936] synonym: "Hedgehog protein processing" NARROW [] synonym: "hh protein processing" EXACT [] synonym: "patched ligand processing" RELATED [] is_a: GO:0051604 ! protein maturation relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0007227 name: signal transduction downstream of smoothened namespace: biological_process def: "The series of molecular signals that are initiated by the transmembrane protein Smoothened. In the presence of a Hedgehog signaling molecule, the Patched protein no longer inhibits the activity of Smoothened, and Smoothened signals via the Hedgehog signaling complex to activate downstream components of the Hedgehog signaling pathway." [PMID:15057936] is_a: GO:0035557 ! intracellular signal transduction involved in cell surface receptor linked signaling relationship: part_of GO:0007224 ! smoothened signaling pathway [Term] id: GO:0007228 name: positive regulation of hh target transcription factor activity namespace: biological_process def: "Any process that increases the activity of a transcription factor that activates transcription of Hedgehog-target genes in response to Smoothened signaling. In Drosophila, Cubitus interruptus (Ci) is the only identified transcription factor so far in the Hedgehog signaling pathway. In vertebrates, members of the Gli protein family are activated in this way. Activation of the Gli/Ci transcription factor is distinct from its stabilization, when proteolytic cleavage is inhibited." [GOC:dph, GOC:tb, PMID:11912487, PMID:15057936] synonym: "activation of hh target transcription factor" EXACT [GOC:dph, GOC:tb] synonym: "positive regulation of hedgehog target transcription factor" EXACT [GOC:bf, GOC:ecd] is_a: GO:0051091 ! positive regulation of transcription factor activity relationship: part_of GO:0007227 ! signal transduction downstream of smoothened [Term] id: GO:0007229 name: integrin-mediated signaling pathway namespace: biological_process def: "Any series of molecular signals generated as a consequence of an integrin binding to one of its physiological ligands." [GOC:mah] synonym: "integrin-mediated signalling pathway" EXACT [] is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0007230 name: calcium-o-sensing receptor pathway namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not make sense. is_obsolete: true consider: GO:0019722 [Term] id: GO:0007231 name: osmosensory signaling pathway namespace: biological_process def: "The series of molecular signals initiated in response to osmotic change." [GOC:jl] subset: gosubset_prok synonym: "osmolarity sensing" EXACT [] synonym: "osmolarity sensing signaling pathway" EXACT [] synonym: "osmolarity sensing signalling pathway" EXACT [] synonym: "osmosensory signalling pathway" EXACT [] synonym: "signal transduction during osmotic stress" EXACT [] is_a: GO:0023033 ! signaling pathway is_a: GO:0071470 ! cellular response to osmotic stress [Term] id: GO:0007232 name: osmosensory signaling pathway via Sho1 osmosensor namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a Sho1 osmosensor system." [GOC:jl] synonym: "osmosensory signalling pathway via Sho1 osmosensor" EXACT [] synonym: "signal transduction during osmotic stress via Sho1 osmosensor" EXACT [] is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007234 name: osmosensory signaling pathway via two-component system namespace: biological_process def: "A series of molecular signals generated in response to osmotic change, as mediated through a two-component (phosphorelay) system." [PMID:9843501] subset: gosubset_prok synonym: "osmolarity sensing via two-component system" EXACT [] synonym: "osmolarity signaling pathway via two-component system" EXACT [] synonym: "osmolarity signalling pathway via two-component system" EXACT [] synonym: "osmosensory signalling pathway via two-component system" EXACT [] synonym: "signal transduction during osmotic stress via two-component system" EXACT [] is_a: GO:0000160 ! two-component signal transduction system (phosphorelay) is_a: GO:0007231 ! osmosensory signaling pathway [Term] id: GO:0007235 name: activation of Ypd1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007236 name: activation of Ssk1 protein namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007237 name: activation of Ssk2/Ssk22 proteins namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007238 name: activation of Pbs2 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007239 name: activation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007240 name: nuclear translocation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007241 name: inactivation of Hog1 namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it contains gene product and species specific information. is_obsolete: true [Term] id: GO:0007243 name: intracellular protein kinase cascade namespace: biological_process def: "A series of reactions that occur within the cell, mediated by protein kinases, which occurs as a result of a single trigger reaction or compound." [GOC:bf, GOC:jl, http://cancerweb.ncl.ac.uk/] synonym: "protein kinase cascade" EXACT [] xref: Reactome:163358 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:563084 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:588695 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:609437 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:634135 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:645645 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:655974 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:661151 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:666935 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:673058 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:678771 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:683699 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:689911 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:701679 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:716256 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:720801 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:728205 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:731164 "PKA-mediated phosphorylation of key metabolic factors" xref: Reactome:735641 "PKA-mediated phosphorylation of key metabolic factors" is_a: GO:0023014 ! signal transmission via phosphorylation event is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007244 name: MAPKKK cascade (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. MAPKKK cascade involved in transduction of mating pheromone signal, as described in Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007245 name: activation of MAPKKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAPKKK activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007246 name: activation of MAPKK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of a MAP kinase kinase in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007247 name: activation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Upregulation of MAP kinase activity in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true consider: GO:0000750 [Term] id: GO:0007248 name: nuclear translocation of MAPK (mating sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Movement of a MAP kinase to the nucleus in the context of transduction of mating pheromone signal, as described for Saccharomyces." [PMID:9561267] comment: This term was made obsolete because it is a gene product specific term. is_obsolete: true replaced_by: GO:0000750 [Term] id: GO:0007249 name: I-kappaB kinase/NF-kappaB cascade namespace: biological_process def: "A series of reactions initiated by the activation of the transcription factor NF-kappaB. NF-kappaB is sequestered by the inhibitor I-kappaB, and is released when I-kappaB is phosphorylated by activated I-kappaB kinase." [GOC:jl, PMID:12773372] synonym: "activation of the inhibitor of kappa kinase" RELATED [] synonym: "NF-kappaB cascade" EXACT [] synonym: "NIK-I-kappaB/NF-kappaB cascade" EXACT [] xref: Reactome:166058 "MyD88 cascade" xref: Reactome:166166 "TRAM Cascade" xref: Reactome:563252 "MyD88 cascade" xref: Reactome:588860 "MyD88 cascade" xref: Reactome:634284 "MyD88 cascade" is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0007250 name: activation of NF-kappaB-inducing kinase activity namespace: biological_process def: "The stimulation of the activity of NF-kappaB-inducing kinase through phosphorylation at specific residues." [GOC:jl, PMID:12773372] synonym: "positive regulation of NF-kappaB-inducing kinase activity" EXACT [] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0032147 ! activation of protein kinase activity is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade relationship: positively_regulates GO:0004704 ! NF-kappaB-inducing kinase activity [Term] id: GO:0007251 name: activation of the inhibitor of kappa kinase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its meaning was unclear. is_obsolete: true consider: GO:0007249 [Term] id: GO:0007252 name: I-kappaB phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into an I-kappaB protein." [GOC:jl] is_a: GO:0006468 ! protein amino acid phosphorylation relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0007253 name: cytoplasmic sequestering of NF-kappaB namespace: biological_process def: "The selective interaction of the transcription factor NF-kappaB with specific molecules in the cytoplasm, thereby inhibiting its translocation into the nucleus." [GOC:jl] synonym: "cytoplasmic NF-kappaB retention" EXACT [] synonym: "cytoplasmic NF-kappaB sequestration" EXACT [] synonym: "cytoplasmic NF-kappaB storage" EXACT [] synonym: "cytoplasmic retention of NF-kappaB" EXACT [] synonym: "cytoplasmic sequestration of NF-kappaB" EXACT [] synonym: "cytoplasmic storage of NF-kappaB" EXACT [] synonym: "maintenance of NF-kappaB location in cytoplasm" EXACT [GOC:dph, GOC:tb] is_a: GO:0042347 ! negative regulation of NF-kappaB import into nucleus is_a: GO:0042994 ! cytoplasmic sequestering of transcription factor relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0007254 name: JNK cascade namespace: biological_process def: "A cascade of protein kinase activities, culminating in the phosphorylation and activation of a member of the JUN kinase subfamily of stress-activated protein kinases, which in turn are a subfamily of mitogen-activated protein (MAP) kinases that is activated primarily by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "JNK1 cascade" NARROW [GOC:add] synonym: "JNK2 cascade" NARROW [GOC:add] synonym: "JNK3 cascade" NARROW [GOC:add] synonym: "MAPK10 cascade" NARROW [GOC:add] synonym: "MAPK8 cascade" NARROW [GOC:add] synonym: "MAPK9 cascade" NARROW [GOC:add] synonym: "SAPK cascade" BROAD [] synonym: "stress-activated protein kinase cascade" BROAD [] xref: Reactome:450321 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:562678 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:588303 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:609043 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:633736 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:645349 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" xref: Reactome:655719 "JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1" is_a: GO:0000165 ! MAPKKK cascade is_a: GO:0031098 ! stress-activated protein kinase signaling cascade [Term] id: GO:0007256 name: activation of JNKK activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase kinase (JNKK) activity in response to phosphorylation by a member of the JUN kinase kinase kinase (JNKKK) family, or another upstream kinase. JNKKs are involved in a signaling pathway that is primarily activated by cytokines and exposure to environmental stress." [GOC:bf, PMID:11790549] synonym: "activation of JUN kinase kinase activity" EXACT [] synonym: "positive regulation of JUNKK activity" BROAD [] is_a: GO:0000186 ! activation of MAPKK activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007257 name: activation of JUN kinase activity namespace: biological_process def: "The initiation of the activity of the inactive enzyme JUN kinase by phosphorylation by a JUN kinase kinase (JNKK)." [GOC:bf] synonym: "activation of SAPK activity" BROAD [] is_a: GO:0000187 ! activation of MAPK activity is_a: GO:0043507 ! positive regulation of JUN kinase activity relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007258 name: JUN phosphorylation namespace: biological_process def: "The process of introducing a phosphate group into a JUN protein." [GOC:jl] is_a: GO:0006468 ! protein amino acid phosphorylation relationship: part_of GO:0007254 ! JNK cascade [Term] id: GO:0007259 name: JAK-STAT cascade namespace: biological_process def: "Any process by which STAT proteins (Signal Transducers and Activators of Transcription) are activated by members of the JAK (janus activated kinase) family of tyrosine kinases, following the binding of cytokines to their cognate receptor. Once activated, STATs dimerize and translocate to the nucleus and modulate the expression of target genes." [GOC:jl, PMID:12039028] is_a: GO:0007243 ! intracellular protein kinase cascade [Term] id: GO:0007260 name: tyrosine phosphorylation of STAT protein namespace: biological_process def: "The process of introducing a phosphate group to a tyrosine residue of a STAT (Signal Transducer and Activator of Transcription) protein." [GOC:jl, PMID:10918594] is_a: GO:0018108 ! peptidyl-tyrosine phosphorylation relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007261 name: JAK-induced STAT protein dimerization namespace: biological_process def: "The formation of a dimer of two STAT proteins (Signal Transducers and Activators of Transcription) following their activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007262 name: STAT protein nuclear translocation namespace: biological_process def: "The transport of dimerized STAT (Signal Transducers and Activators of Transcription) proteins into the nucleus following activation by members of the janus activated kinase (JAK) family of tyrosine kinases." [GOC:jl, PMID:12039028] is_a: GO:0000060 ! protein import into nucleus, translocation relationship: part_of GO:0007259 ! JAK-STAT cascade [Term] id: GO:0007263 name: nitric oxide mediated signal transduction namespace: biological_process def: "A series of molecular signals mediated by the detection of nitric oxide (NO)." [GOC:jl] synonym: "nitric oxide-mediated signal transduction" EXACT [] synonym: "NO mediated signal transduction" EXACT [] synonym: "NO-mediated signal transduction" EXACT [] is_a: GO:0023033 ! signaling pathway [Term] id: GO:0007264 name: small GTPase mediated signal transduction namespace: biological_process def: "Any series of molecular signals in which a small monomeric GTPase relays one or more of the signals." [GOC:mah] subset: gosubset_prok synonym: "small GTPase-mediated signal transduction" EXACT [] xref: Reactome:187706 "Signalling to p38 via RIT and RIN" xref: Reactome:194315 "Signaling by Rho GTPases" xref: Reactome:562707 "Signalling to p38 via RIT and RIN" xref: Reactome:563133 "Signaling by Rho GTPases" xref: Reactome:588328 "Signalling to p38 via RIT and RIN" xref: Reactome:588745 "Signaling by Rho GTPases" xref: Reactome:609072 "Signalling to p38 via RIT and RIN" xref: Reactome:609476 "Signaling by Rho GTPases" xref: Reactome:633765 "Signalling to p38 via RIT and RIN" xref: Reactome:634181 "Signaling by Rho GTPases" xref: Reactome:645375 "Signalling to p38 via RIT and RIN" xref: Reactome:645683 "Signaling by Rho GTPases" xref: Reactome:655743 "Signalling to p38 via RIT and RIN" xref: Reactome:656013 "Signaling by Rho GTPases" xref: Reactome:661189 "Signalling to p38 via RIT and RIN" xref: Reactome:661201 "Signaling by Rho GTPases" xref: Reactome:666967 "Signalling to p38 via RIT and RIN" xref: Reactome:666978 "Signaling by Rho GTPases" xref: Reactome:673102 "Signalling to p38 via RIT and RIN" xref: Reactome:673114 "Signaling by Rho GTPases" xref: Reactome:678802 "Signalling to p38 via RIT and RIN" xref: Reactome:678814 "Signaling by Rho GTPases" xref: Reactome:683730 "Signalling to p38 via RIT and RIN" xref: Reactome:683742 "Signaling by Rho GTPases" xref: Reactome:689947 "Signalling to p38 via RIT and RIN" xref: Reactome:689961 "Signaling by Rho GTPases" xref: Reactome:701722 "Signalling to p38 via RIT and RIN" xref: Reactome:701735 "Signaling by Rho GTPases" xref: Reactome:716299 "Signalling to p38 via RIT and RIN" xref: Reactome:716312 "Signaling by Rho GTPases" xref: Reactome:720820 "Signaling by Rho GTPases" xref: Reactome:728242 "Signalling to p38 via RIT and RIN" xref: Reactome:728257 "Signaling by Rho GTPases" xref: Reactome:731078 "Signalling to p38 via RIT and RIN" is_a: GO:0035556 ! intracellular signal transduction [Term] id: GO:0007265 name: Ras protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Ras superfamily of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Ras mediated signal transduction" EXACT [] xref: Reactome:167044 "Signalling to RAS" xref: Reactome:562701 "Signalling to RAS" xref: Reactome:588322 "Signalling to RAS" xref: Reactome:609066 "Signalling to RAS" xref: Reactome:633759 "Signalling to RAS" xref: Reactome:645368 "Signalling to RAS" xref: Reactome:655736 "Signalling to RAS" xref: Reactome:661179 "Signalling to RAS" xref: Reactome:666957 "Signalling to RAS" xref: Reactome:673092 "Signalling to RAS" xref: Reactome:678792 "Signalling to RAS" xref: Reactome:683720 "Signalling to RAS" xref: Reactome:689937 "Signalling to RAS" xref: Reactome:701712 "Signalling to RAS" xref: Reactome:716289 "Signalling to RAS" xref: Reactome:728232 "Signalling to RAS" xref: Reactome:731068 "Signalling to RAS" is_a: GO:0007264 ! small GTPase mediated signal transduction [Term] id: GO:0007266 name: Rho protein signal transduction namespace: biological_process def: "A series of molecular signals within the cell that are mediated by a member of the Rho family of proteins switching to a GTP-bound active state." [GOC:bf] synonym: "Rho mediated signal transduction" EXACT [] is_a: GO:0007265 ! Ras protein signal transduction [Term] id: GO:0007267 name: cell-cell signaling namespace: biological_process def: "Any process that mediates the transfer of information from one cell to another." [GOC:mah] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "cell-cell signalling" EXACT [] synonym: "paracrine signaling" NARROW [] is_a: GO:0007154 ! cell communication is_a: GO:0023052 ! signaling [Term] id: GO:0007268 name: synaptic transmission namespace: biological_process def: "The process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse." [GOC:jl, MeSH:D009435] synonym: "neurotransmission" RELATED [GOC:dph] synonym: "regulation of synapse" RELATED [] synonym: "signal transmission across a synapse" EXACT [] xref: Reactome:112315 "Transmission across Chemical Synapses" xref: Reactome:112316 "Synaptic Transmission" xref: Reactome:562630 "Transmission across Chemical Synapses" xref: Reactome:562631 "Synaptic Transmission" xref: Reactome:588256 "Transmission across Chemical Synapses" xref: Reactome:588257 "Synaptic Transmission" xref: Reactome:609013 "Transmission across Chemical Synapses" xref: Reactome:609014 "Synaptic Transmission" xref: Reactome:633703 "Transmission across Chemical Synapses" xref: Reactome:633704 "Synaptic Transmission" xref: Reactome:645318 "Transmission across Chemical Synapses" xref: Reactome:645319 "Synaptic Transmission" xref: Reactome:655691 "Transmission across Chemical Synapses" xref: Reactome:655692 "Synaptic Transmission" xref: Reactome:660965 "Transmission across Chemical Synapses" xref: Reactome:660966 "Synaptic Transmission" xref: Reactome:666739 "Transmission across Chemical Synapses" xref: Reactome:666740 "Synaptic Transmission" xref: Reactome:672844 "Transmission across Chemical Synapses" xref: Reactome:672845 "Synaptic Transmission" xref: Reactome:678566 "Transmission across Chemical Synapses" xref: Reactome:678567 "Synaptic Transmission" xref: Reactome:683523 "Transmission across Chemical Synapses" xref: Reactome:683524 "Synaptic Transmission" xref: Reactome:689725 "Transmission across Chemical Synapses" xref: Reactome:689726 "Synaptic Transmission" xref: Reactome:701456 "Transmission across Chemical Synapses" xref: Reactome:701457 "Synaptic Transmission" xref: Reactome:716027 "Transmission across Chemical Synapses" xref: Reactome:716028 "Synaptic Transmission" xref: Reactome:720687 "Transmission across Chemical Synapses" xref: Reactome:720688 "Synaptic Transmission" xref: Reactome:727977 "Transmission across Chemical Synapses" xref: Reactome:727978 "Synaptic Transmission" xref: Reactome:730940 "Transmission across Chemical Synapses" xref: Reactome:730941 "Synaptic Transmission" xref: Reactome:733016 "Transmission across Chemical Synapses" xref: Reactome:733017 "Synaptic Transmission" xref: Reactome:733854 "Transmission across Chemical Synapses" xref: Reactome:733855 "Synaptic Transmission" xref: Reactome:735576 "Transmission across Chemical Synapses" xref: Reactome:735577 "Synaptic Transmission" xref: Reactome:738486 "Transmission across Chemical Synapses" xref: Reactome:738487 "Synaptic Transmission" xref: Wikipedia:Neurotransmission is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0019226 ! transmission of nerve impulse [Term] id: GO:0007269 name: neurotransmitter secretion namespace: biological_process def: "The regulated release of neurotransmitter into the synaptic cleft. A neurotransmitter is any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. Among the many substances that have the properties of a neurotransmitter are acetylcholine, noradrenaline, adrenaline, dopamine, glycine, gamma-aminobutyrate, glutamic acid, substance P, enkephalins, endorphins and serotonin." [GOC:dph, http://cancerweb.ncl.ac.uk] synonym: "neurotransmitter release" EXACT [] xref: Reactome:112310 "Neurotransmitter Release Cycle" xref: Reactome:168799 "Botulinum neurotoxicity" xref: Reactome:563099 "Neurotransmitter Release Cycle" xref: Reactome:588710 "Neurotransmitter Release Cycle" xref: Reactome:609453 "Neurotransmitter Release Cycle" xref: Reactome:634149 "Neurotransmitter Release Cycle" xref: Reactome:645659 "Neurotransmitter Release Cycle" xref: Reactome:655993 "Neurotransmitter Release Cycle" xref: Reactome:661165 "Neurotransmitter Release Cycle" xref: Reactome:673071 "Neurotransmitter Release Cycle" xref: Reactome:683884 "Neurotransmitter Release Cycle" xref: Reactome:690035 "Neurotransmitter Release Cycle" xref: Reactome:701694 "Neurotransmitter Release Cycle" xref: Reactome:716271 "Neurotransmitter Release Cycle" xref: Reactome:720866 "Neurotransmitter Release Cycle" xref: Reactome:728316 "Neurotransmitter Release Cycle" xref: Reactome:733128 "Neurotransmitter Release Cycle" xref: Reactome:735663 "Neurotransmitter Release Cycle" xref: Reactome:738599 "Neurotransmitter Release Cycle" is_a: GO:0001505 ! regulation of neurotransmitter levels is_a: GO:0006836 ! neurotransmitter transport is_a: GO:0023061 ! signal release is_a: GO:0032940 ! secretion by cell [Term] id: GO:0007270 name: nerve-nerve synaptic transmission namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse." [GOC:jl, MeSH:D009435] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007271 name: synaptic transmission, cholinergic namespace: biological_process def: "The process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine." [GOC:kmv] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007272 name: ensheathment of neurons namespace: biological_process def: "The process whereby glial cells envelop neuronal cell bodies and/or axons to form an insulating layer. This can take the form of myelinating or non-myelinating ensheathment." [GOC:dgh, GOC:dph, GOC:tb] synonym: "ionic insulation of neurons by glial cells" RELATED [] is_a: GO:0009987 ! cellular process relationship: part_of GO:0007399 ! nervous system development relationship: part_of GO:0019228 ! regulation of action potential in neuron [Term] id: GO:0007273 name: regulation of synapse namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term string made no sense. is_obsolete: true consider: GO:0007268 [Term] id: GO:0007274 name: neuromuscular synaptic transmission namespace: biological_process def: "The process of communication from a neuron to a muscle, across a synapse." [GOC:jl, MeSH:D009435] is_a: GO:0007268 ! synaptic transmission [Term] id: GO:0007275 name: multicellular organismal development namespace: biological_process def: "The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult)." [GOC:dph, GOC:ems, GOC:isa_complete, GOC:tb] comment: Note that this term was 'developmental process'. subset: goslim_generic subset: goslim_goa subset: goslim_plant is_a: GO:0032501 ! multicellular organismal process is_a: GO:0032502 ! developmental process [Term] id: GO:0007276 name: gamete generation namespace: biological_process alt_id: GO:0009552 def: "The generation and maintenance of gametes in a multicellular organism. A gamete is a haploid reproductive cell." [GOC:ems, GOC:mtg_sensu] synonym: "gametogenesis" RELATED [] is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0007277 name: pole cell development namespace: biological_process def: "The process whose specific outcome is the progression of the pole cell over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048468 ! cell development is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007278 name: pole cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a pole cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007279 name: pole cell formation namespace: biological_process def: "Formation of a small group of cells (pole cells) at the posterior pole of the insect blastula. They are the first cells to cellularize after the arrival of nuclei at the end of the syncytial blastula stage and are the precursors to the insect germ cells." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0003006 ! reproductive developmental process is_a: GO:0007349 ! cellularization relationship: part_of GO:0007277 ! pole cell development [Term] id: GO:0007280 name: pole cell migration namespace: biological_process def: "The directed movement of a pole cell (germline progenitors in insects) from its site of production at the posterior pole of the embryo through to the site where the gonads will form." [GOC:bf, PMID:9988212] comment: See also the Cell Ontology term 'pole cell ; CL:0000301'. is_a: GO:0008354 ! germ cell migration [Term] id: GO:0007281 name: germ cell development namespace: biological_process def: "The process whose specific outcome is the progression of an immature germ cell over time, from its formation to the mature structure (gamete). A germ cell is any reproductive cell in a multicellular organism." [GOC:go_curators] synonym: "germ-cell development" EXACT [] synonym: "primordial germ cell development" NARROW [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048468 ! cell development is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0007282 name: cystoblast division namespace: biological_process def: "The four rounds of incomplete mitosis undergone by the cystoblast to form a 16-cell cyst. Within the cyst, one cell differentiates into an oocyte while the rest become nurse cells. An example of this is found in Drosophila melanogaster." [PMID:11131529] synonym: "cystoblast cell division" EXACT [] is_a: GO:0008356 ! asymmetric cell division is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007281 ! germ cell development [Term] id: GO:0007283 name: spermatogenesis namespace: biological_process def: "The process of formation of spermatozoa, including spermatocytogenesis and spermiogenesis." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "generation of spermatozoa" EXACT systematic_synonym [] xref: Wikipedia:Spermatogenesis is_a: GO:0048232 ! male gamete generation [Term] id: GO:0007284 name: spermatogonial cell division namespace: biological_process def: "The mitotic divisions of the primary spermatogonial cell (a primordial male germ cell) to form a cyst of secondary spermatogonia (primary spermatocytes)." [GOC:bf, ISBN:0879694238] comment: See also the Cell Ontology terms 'spermatogonium ; CL:0000020' and 'primary spermatocyte ; CL:0000656'. is_a: GO:0048610 ! reproductive cellular process is_a: GO:0051301 ! cell division relationship: part_of GO:0048136 ! male germ-line cyst formation [Term] id: GO:0007285 name: primary spermatocyte growth namespace: biological_process def: "The phase of growth and gene expression that male germ cells undergo as they enter the spermatocyte stage. The cells grow in volume and transcribe most of the gene products needed for the morphological events that follow meiosis." [GOC:jid, ISBN:0879694238] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007283 ! spermatogenesis [Term] id: GO:0007286 name: spermatid development namespace: biological_process def: "The process whose specific outcome is the progression of a spermatid over time, from its formation to the mature structure." [GOC:dph, GOC:go_curators] synonym: "spermatid cell development" EXACT [] synonym: "spermiogenesis" EXACT [] xref: Wikipedia:Spermiogenesis is_a: GO:0007281 ! germ cell development relationship: part_of GO:0048515 ! spermatid differentiation [Term] id: GO:0007287 name: Nebenkern assembly namespace: biological_process def: "Fusion of mitochondria during insect spermatid differentiation to form two masses, which wrap around each other to form a densely packed sphere called the Nebenkern." [GOC:bf, ISBN:0879694238] comment: See also the cellular component term 'Nebenkern ; GO:0016006', and the fly_anatomy.ontology term 'Nebenkern ; FBbt:00004943'. synonym: "Nebenkern formation" RELATED [GOC:dph] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0008053 ! mitochondrial fusion is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007288 name: sperm axoneme assembly namespace: biological_process def: "The assembly and organization of the sperm flagellar axoneme, the bundle of microtubules and associated proteins that forms the core of the eukaryotic sperm flagellum, and is responsible for movement." [GOC:bf, ISBN:0198547684] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0035084 ! flagellar axoneme assembly is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007289 name: spermatid nucleus differentiation namespace: biological_process def: "The specialization of the spermatid nucleus during the development of a spermatid into a mature male gamete competent for fertilization." [GOC:bf, GOC:dph, GOC:jl, GOC:mah] comment: See also the Cell Ontology term 'spermatid ; CL:0000018'. synonym: "spermatid nuclear differentiation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007290 name: spermatid nucleus elongation namespace: biological_process def: "The change in shape of the spermatid nucleus from a spherical structure to an elongated organelle, during the latter part of spermatid differentiation." [GOC:bf, GOC:dph, GOC:jl, GOC:mah, ISBN:0879694238] synonym: "spermatid nuclear elongation" EXACT [] is_a: GO:0006997 ! nucleus organization is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007289 ! spermatid nucleus differentiation [Term] id: GO:0007291 name: sperm individualization namespace: biological_process def: "The resolution of the male germline syncytium or cyst into individual gametes by packaging each spermatid into its own plasma membrane." [GOC:bf, PMID:9550716] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0007349 ! cellularization relationship: part_of GO:0007286 ! spermatid development [Term] id: GO:0007292 name: female gamete generation namespace: biological_process def: "Generation of the female gamete; specialised haploid cells produced by meiosis and along with a male gamete takes part in sexual reproduction." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007276 ! gamete generation [Term] id: GO:0007293 name: germarium-derived egg chamber formation namespace: biological_process def: "Construction of a stage-1 egg chamber in the anterior part of the germarium, from the progeny of germ-line and somatic stem cells. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007294 name: germarium-derived oocyte fate determination namespace: biological_process alt_id: GO:0016350 def: "Process by which a germarium-derived cell becomes capable of differentiating autonomously into an oocyte cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maintenance of oocyte identity" RELATED [] synonym: "oocyte cell fate determination" RELATED [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0030716 ! oocyte fate determination is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0030706 ! germarium-derived oocyte differentiation [Term] id: GO:0007295 name: growth of a germarium-derived egg chamber namespace: biological_process def: "Growth of the egg chamber between the time it leaves the germarium and the onset of vitellogenesis. During this time both nurse cells and the oocyte undergo developmental changes including nuclear organization and cytoplasmic growth. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "egg chamber growth" EXACT [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048589 ! developmental growth relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007296 name: vitellogenesis namespace: biological_process def: "The production of yolk. Yolk is a mixture of materials used for embryonic nutrition." [GOC:dph, ISBN:0879694238] synonym: "yolk production" EXACT systematic_synonym [] xref: Wikipedia:Vitellogenesis is_a: GO:0007028 ! cytoplasm organization is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007292 ! female gamete generation [Term] id: GO:0007297 name: ovarian follicle cell migration namespace: biological_process def: "The directed movement of an ovarian follicle cell that takes place during oogenesis. During egg chamber formation, follicle cells migrate to envelop the germ-line cysts and move in between cysts. At stage 10B, follicle cells migrate centripetally between the nurse cells and the oocyte, enclosing the anterior of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "follicle cell migration" BROAD [] is_a: GO:0016477 ! cell migration is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007298 name: border follicle cell migration namespace: biological_process def: "The directed movement of a border cell through the nurse cells to reach the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:10822261] synonym: "border cell migration" BROAD [] is_a: GO:0007297 ! ovarian follicle cell migration [Term] id: GO:0007299 name: ovarian follicle cell-cell adhesion namespace: biological_process def: "The attachment of a somatic follicle cell to another somatic follicle cell or to its substratum, the germline cells. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12642496] synonym: "follicle cell adhesion" BROAD [] synonym: "ovarian follicle cell adhesion" EXACT [GOC:curators] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007300 name: ovarian nurse cell to oocyte transport namespace: biological_process def: "Transfer of constituents synthesized in the ovarian nurse cells to the oocyte, through the ring canals, as the egg chamber is growing. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "nurse cell to oocyte transport" BROAD [] is_a: GO:0006810 ! transport relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0007301 name: female germline ring canal formation namespace: biological_process def: "Assembly of the intercellular bridges that connect the germ-line cells of a female cyst." [ISBN:0879694238] synonym: "nurse cell ring canal formation" NARROW [] synonym: "ovarian ring canal formation" NARROW [] is_a: GO:0030725 ! germline ring canal formation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007293 ! germarium-derived egg chamber formation relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007302 name: nurse cell nucleus anchoring namespace: biological_process def: "Attachment of the nurse cell nucleus to the plasma membrane." [ISBN:0879694238] is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007303 name: cytoplasmic transport, nurse cell to oocyte namespace: biological_process def: "The directed movement of cytoplasmic constituents synthesized in the nurse cells to the oocyte." [ISBN:0879694238] is_a: GO:0016482 ! cytoplasmic transport relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0007304 name: chorion-containing eggshell formation namespace: biological_process def: "The construction of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "eggshell formation" BROAD [] is_a: GO:0030703 ! eggshell formation relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0007305 name: vitelline membrane formation in chorion-containing eggshell namespace: biological_process def: "Construction of the vitelline membrane portion of a chorion-containing eggshell. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] is_a: GO:0030704 ! vitelline membrane formation relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007306 name: eggshell chorion assembly namespace: biological_process def: "Construction of the chorion portion of the eggshell, which comprises the channels for gas exchange in an insect eggshell." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "eggshell chorion formation" EXACT [GOC:dph, GOC:tb] synonym: "insect chorion formation" RELATED [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010927 ! cellular component assembly involved in morphogenesis relationship: part_of GO:0007304 ! chorion-containing eggshell formation [Term] id: GO:0007307 name: eggshell chorion gene amplification namespace: biological_process def: "Amplification by up to 60-fold of the loci containing the chorion gene clusters. Amplification is necessary for the rapid synthesis of chorion proteins by the follicle cells, and occurs by repeated firing of one or more origins located within each gene cluster." [GOC:mtg_sensu, PMID:11157771] is_a: GO:0006277 ! DNA amplification relationship: part_of GO:0007306 ! eggshell chorion assembly [Term] id: GO:0007308 name: oocyte construction namespace: biological_process alt_id: GO:0048110 def: "The synthesis, deposition, and organization of the materials in a cell of an ovary; where the cell can then undergo meiosis and form an ovum. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:ems, GOC:mtg_sensu, GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "oocyte arrangement" EXACT [GOC:dph, GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048469 ! cell maturation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048599 ! oocyte development [Term] id: GO:0007309 name: oocyte axis specification namespace: biological_process alt_id: GO:0048111 def: "The establishment, maintenance and elaboration of an axis in the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte axis determination" RELATED [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009798 ! axis specification relationship: part_of GO:0007308 ! oocyte construction [Term] id: GO:0007310 name: oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008072 alt_id: GO:0048123 def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "oocyte dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "oocyte dorsal/ventral axis determination" RELATED [GOC:dph, GOC:tb] synonym: "oocyte dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007311 name: maternal specification of dorsal/ventral axis, oocyte, germ-line encoded namespace: biological_process alt_id: GO:0048124 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by cells of the germ line. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, germ-line encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, germ-line encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007312 name: oocyte nucleus migration involved in oocyte dorsal/ventral axis specification namespace: biological_process alt_id: GO:0008102 alt_id: GO:0048128 def: "The directed movement of the oocyte nucleus within the cell as part of the establishment and maintenance of the dorsal/ventral axis of the oocyte. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mah, GOC:mtg_sensu, GOC:tb] synonym: "oocyte axis determination, oocyte nuclear migration" EXACT [] synonym: "oocyte axis determination, oocyte nucleus migration" EXACT [] synonym: "oocyte nuclear migration during oocyte axis determination" EXACT [] synonym: "oocyte nucleus migration during oocyte axis determination" EXACT [GOC:dph, GOC:tb] synonym: "oocyte nucleus migration during oocyte axis specification" RELATED [GOC:dph, GOC:tb] is_a: GO:0007097 ! nuclear migration is_a: GO:0030722 ! establishment of oocyte nucleus localization involved in oocyte dorsal/ventral axis specification [Term] id: GO:0007313 name: maternal specification of dorsal/ventral axis, oocyte, soma encoded namespace: biological_process alt_id: GO:0048125 def: "Polarization of the oocyte along the dorsal-ventral axis, by a gene product encoded by somatic cells. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "maternal determination of dorsal/ventral axis, oocyte, soma encoded" EXACT [GOC:dph, GOC:tb] synonym: "maternal specification of dorsal-ventral axis, oocyte, soma encoded" EXACT [GOC:mah] synonym: "maternal specification of dorsoventral axis, oocyte, soma encoded" EXACT [GOC:mah] is_a: GO:0007310 ! oocyte dorsal/ventral axis specification [Term] id: GO:0007314 name: oocyte anterior/posterior axis specification namespace: biological_process alt_id: GO:0048112 def: "Polarization of the oocyte along its anterior-posterior axis. An example of this is found in Drosophila melanogaster." [GOC:dph, GOC:mtg_sensu, GOC:tb, ISBN:0879694238] synonym: "oocyte anterior/posterior axis determination" EXACT [GOC:dph, GOC:tb] is_a: GO:0007309 ! oocyte axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0008358 ! maternal determination of anterior/posterior axis, embryo [Term] id: GO:0007315 name: pole plasm assembly namespace: biological_process alt_id: GO:0048113 def: "Establishment of the specialized cytoplasm found at the poles of the egg. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu] is_a: GO:0007028 ! cytoplasm organization is_a: GO:0022607 ! cellular component assembly is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007314 ! oocyte anterior/posterior axis specification [Term] id: GO:0007316 name: pole plasm RNA localization namespace: biological_process alt_id: GO:0048116 def: "Any process by which RNA is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm RNA localization" EXACT [] synonym: "oocyte pole plasm RNA localization" EXACT [] is_a: GO:0006403 ! RNA localization relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007317 name: regulation of pole plasm oskar mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process by which oskar mRNA is transported to, or maintained in, the oocyte pole plasm." [GOC:hb] synonym: "regulation of oocyte pole plasm oskar mRNA localization" EXACT [] is_a: GO:0044087 ! regulation of cellular component biogenesis is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0051128 ! regulation of cellular component organization is_a: GO:0060281 ! regulation of oocyte development is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045451 ! pole plasm oskar mRNA localization relationship: regulates GO:0045451 ! pole plasm oskar mRNA localization [Term] id: GO:0007318 name: pole plasm protein localization namespace: biological_process alt_id: GO:0048115 def: "Any process by which a protein is transported to, or maintained in, the oocyte pole plasm. An example of this is found in Drosophila melanogaster." [GOC:ai] synonym: "establishment and maintenance of pole plasm protein localization" EXACT [] synonym: "oocyte pole plasm protein localization" EXACT [] is_a: GO:0008105 ! asymmetric protein localization relationship: part_of GO:0007315 ! pole plasm assembly [Term] id: GO:0007319 name: negative regulation of oskar mRNA translation namespace: biological_process def: "Any process that stops, prevents or reduces the rate that oskar mRNAs are effectively translated into protein." [GOC:ems] synonym: "down regulation of oskar mRNA translation" EXACT [] synonym: "down-regulation of oskar mRNA translation" EXACT [] synonym: "downregulation of oskar mRNA translation" EXACT [] synonym: "inhibition of oskar mRNA translation" NARROW [] is_a: GO:0017148 ! negative regulation of translation is_a: GO:0046011 ! regulation of oskar mRNA translation [Term] id: GO:0007320 name: insemination namespace: biological_process def: "The introduction of semen or sperm into the genital tract of a female." [ISBN:0582227089] xref: Wikipedia:Insemination is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0007620 ! copulation [Term] id: GO:0007321 name: sperm displacement namespace: biological_process def: "The physical displacement of sperm stored from previous mating encounters." [PMID:10440373] is_a: GO:0046692 ! sperm competition [Term] id: GO:0007323 name: peptide pheromone maturation namespace: biological_process alt_id: GO:0007324 alt_id: GO:0007326 alt_id: GO:0046613 def: "The generation of a mature, active peptide pheromone via processes unique to its processing and modification. An example of this process is found in Saccharomyces cerevisiae." [GOC:elh] subset: gosubset_prok synonym: "pheromone processing" EXACT [] is_a: GO:0051604 ! protein maturation [Term] id: GO:0007329 name: positive regulation of transcription from RNA polymerase II promoter by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription from an RNA polymerase II promoter." [GOC:go_curators] synonym: "activation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "positive regulation of transcription from Pol II promoter by pheromones" EXACT [] synonym: "stimulation of transcription from RNA polymerase II promoter by pheromones" NARROW [] synonym: "up regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "up-regulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] synonym: "upregulation of transcription from RNA polymerase II promoter by pheromones" EXACT [] is_a: GO:0009371 ! positive regulation of transcription by pheromones is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter is_a: GO:0046019 ! regulation of transcription from RNA polymerase II promoter by pheromones [Term] id: GO:0007336 name: bilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. is_obsolete: true [Term] id: GO:0007337 name: unilateral process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it gives no indication of what it refers to. is_obsolete: true [Term] id: GO:0007338 name: single fertilization namespace: biological_process def: "The union of male and female gametes to form a zygote." [GOC:ems, GOC:mtg_sensu] synonym: "zygote biosynthesis" BROAD [] synonym: "zygote formation" BROAD [] is_a: GO:0009566 ! fertilization [Term] id: GO:0007339 name: binding of sperm to zona pellucida namespace: biological_process def: "The process by which the sperm binds to the zona pellucida glycoprotein layer of the egg. The process begins with the attachment of the sperm plasma membrane to the zona pellucida and includes attachment of the acrosome inner membrane to the zona pellucida after the acrosomal reaction takes place." [GOC:dph, ISBN:0878932437] synonym: "ZPG binding" RELATED [] is_a: GO:0035036 ! sperm-egg recognition [Term] id: GO:0007340 name: acrosome reaction namespace: biological_process def: "The discharge, by sperm, of a single, anterior secretory granule following the sperm's attachment to the zona pellucida surrounding the oocyte. The process begins with the fusion of the outer acrosomal membrane with the sperm plasma membrane and ends with the exocytosis of the acrosomal contents into the egg." [GOC:dph, PMID:3886029] xref: Wikipedia:Acrosome_reaction is_a: GO:0017156 ! calcium ion-dependent exocytosis is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007341 name: penetration of zona pellucida namespace: biological_process def: "The infiltration by sperm of the zona pellucida to reach the oocyte. The process involves digestive enzymes from a modified lysosome called the acrosome, situated at the head of the sperm." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007342 name: fusion of sperm to egg plasma membrane namespace: biological_process def: "The binding and fusion of a sperm, having penetrated the zona pellucida, with the plasma membrane of the oocyte. Binding occurs at the posterior (post-acrosomal) region of the sperm head." [GOC:jl, http://arbl.cvmbs.colostate.edu/hbooks/pathphys/reprod/fert/fert.html] synonym: "sperm-oocyte fusion" NARROW [] is_a: GO:0045026 ! plasma membrane fusion relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007343 name: egg activation namespace: biological_process def: "The process whereby the egg becomes metabolically active, initiates protein and DNA synthesis and undergoes structural changes to its cortex and/or cytoplasm." [GOC:bf, PMID:9630751] xref: Wikipedia:Egg_activation is_a: GO:0001775 ! cell activation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007344 name: pronuclear fusion namespace: biological_process def: "The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome." [GOC:ems, ISBN:087969307X] is_a: GO:0000741 ! karyogamy is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007338 ! single fertilization [Term] id: GO:0007345 name: embryogenesis and morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of an embryo and its organized structures." [GOC:ems, ISBN:0070524300, ISBN:0140512888] comment: This term was made obsolete because more appropriate terms were created. Morphogenesis in plants also occurs outside of embryogenesis. is_obsolete: true consider: GO:0009653 consider: GO:0009790 [Term] id: GO:0007346 name: regulation of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progress through the mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] subset: goslim_pombe synonym: "control of mitotic cell cycle progression" EXACT [] synonym: "mitotic cell cycle control" EXACT [] synonym: "mitotic cell cycle modulation" EXACT [] synonym: "mitotic cell cycle regulation" EXACT [] synonym: "mitotic cell cycle regulator" RELATED [] synonym: "modulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0051726 ! regulation of cell cycle intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000278 ! mitotic cell cycle relationship: regulates GO:0000278 ! mitotic cell cycle [Term] id: GO:0007347 name: regulation of preblastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the preblastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "modulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "preblastoderm mitotic cell cycle control" EXACT [] synonym: "preblastoderm mitotic cell cycle modulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulation" EXACT [] synonym: "preblastoderm mitotic cell cycle regulator" RELATED [] synonym: "regulation of preblastoderm mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through preblastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035185 ! preblastoderm mitotic cell cycle relationship: regulates GO:0035185 ! preblastoderm mitotic cell cycle [Term] id: GO:0007348 name: regulation of syncytial blastoderm mitotic cell cycle namespace: biological_process def: "A cell cycle process that modulates the rate or extent of the progression through the syncytial blastoderm mitotic cell cycle." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of syncytial blastoderm cell cycle progression" EXACT [] synonym: "modulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "regulation of progression through syncytial blastoderm mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of syncytial blastoderm cell cycle" EXACT [] synonym: "regulation of syncytial blastoderm cell cycle progression" EXACT [] synonym: "syncytial blastoderm cell cycle control" EXACT [] synonym: "syncytial blastoderm cell cycle modulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulation" EXACT [] synonym: "syncytial blastoderm cell cycle regulator" RELATED [] is_a: GO:0009794 ! regulation of mitotic cell cycle, embryonic is_a: GO:0022402 ! cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle relationship: regulates GO:0035186 ! syncytial blastoderm mitotic cell cycle [Term] id: GO:0007349 name: cellularization namespace: biological_process alt_id: GO:0009796 def: "The separation of a multi-nucleate cell or syncytium into individual cells. An example of this is found in Drosophila melanogaster embryo development." [GOC:go_curators, GOC:mtg_sensu, ISBN:0716731363] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007350 name: blastoderm segmentation namespace: biological_process def: "The hierarchical steps resulting in the progressive subdivision of the anterior/posterior axis of the embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification is_a: GO:0035282 ! segmentation [Term] id: GO:0007351 name: tripartite regional subdivision namespace: biological_process def: "Subdivision of the embryo along the anterior/posterior axis into anterior, posterior and terminal regions." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007352 name: zygotic specification of dorsal/ventral axis namespace: biological_process def: "The specification of the dorsal/ventral axis of the embryo, through the products of genes expressed in the zygote." [GOC:bf] synonym: "zygotic determination of dorsal-ventral axis" RELATED [GOC:mah] synonym: "zygotic determination of dorsal/ventral axis" RELATED [GOC:dph] synonym: "zygotic determination of dorsoventral axis" RELATED [GOC:mah] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0007353 name: ventral/lateral system namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0009880 [Term] id: GO:0007354 name: zygotic determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by products of genes expressed in the zygote; exemplified in insects by the gap genes, pair rule genes and segment polarity gene cascade." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0007355 name: anterior region determination namespace: biological_process def: "Specification of the anterior (head and thoracic segments) of the embryo by the gap genes; exemplified in insects by the actions of hunchback gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007356 name: thorax and anterior abdomen determination namespace: biological_process def: "Specification of the central (trunk) regions of the embryo by the gap genes; exemplified in insects by the actions of the Kruppel gene product." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007357 name: positive regulation of central gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the central region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila Kruppel gene by the hunchback and bicoid gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of central gap gene" BROAD [] synonym: "activation of central gap gene transcription" NARROW [] synonym: "stimulation of central gap gene transcription" NARROW [] synonym: "up regulation of central gap gene transcription" EXACT [] synonym: "up-regulation of central gap gene transcription" EXACT [] synonym: "upregulation of central gap gene transcription" EXACT [] is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007358 name: establishment of central gap gene boundaries namespace: biological_process def: "Specification of the borders of central gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by knirps repression of Kruppel." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007356 ! thorax and anterior abdomen determination [Term] id: GO:0007359 name: posterior abdomen determination namespace: biological_process def: "The regionalization process by which the posterior (abdominal) regions of the embryo are specified by the gap genes." [GOC:dph, GOC:isa_complete, http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] comment: Note that this process is exemplified in insects by the actions of the knirps gene product. is_a: GO:0009952 ! anterior/posterior pattern formation relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007360 name: positive regulation of posterior gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors in the posterior region of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila knirps gene." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of posterior gap gene" BROAD [] synonym: "activation of posterior gap gene transcription" NARROW [] synonym: "knirps activation" NARROW [] synonym: "stimulation of posterior gap gene transcription" NARROW [] synonym: "up regulation of posterior gap gene transcription" EXACT [] synonym: "up-regulation of posterior gap gene transcription" EXACT [] synonym: "upregulation of posterior gap gene transcription" EXACT [] is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007361 name: establishment of posterior gap gene boundaries namespace: biological_process def: "Specification of the borders of posterior gap gene expression mediated largely by the effects of other gap genes; in insects this is exemplified by hunchback and tailless repression of knirps." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007359 ! posterior abdomen determination [Term] id: GO:0007362 name: terminal region determination namespace: biological_process def: "Specification of the terminal regions (the two non-segmented ends) of the embryo by the gap genes; exemplified in insects by the actions of huckebein and tailless gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0009880 ! embryonic pattern specification relationship: part_of GO:0007354 ! zygotic determination of anterior/posterior axis, embryo [Term] id: GO:0007363 name: positive regulation of terminal gap gene transcription namespace: biological_process def: "The activation of genes encoding transcription factors at the anterior and posterior ends of an insect embryo by a combination of maternal regulatory signals and interactions among themselves; exemplified by the activation of expression of the Drosophila tailless and huckebein genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "activation of terminal gap gene" BROAD [] synonym: "activation of terminal gap gene transcription" NARROW [] synonym: "stimulation of terminal gap gene transcription" NARROW [] synonym: "up regulation of terminal gap gene transcription" EXACT [] synonym: "up-regulation of terminal gap gene transcription" EXACT [] synonym: "upregulation of terminal gap gene transcription" EXACT [] is_a: GO:0010552 ! positive regulation of gene-specific transcription from RNA polymerase II promoter relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007364 name: establishment of terminal gap gene boundary namespace: biological_process def: "Specification of the borders of terminal gap gene expression mediated largely by the effects of other gap genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0007362 ! terminal region determination [Term] id: GO:0007365 name: periodic partitioning namespace: biological_process def: "The regionalization process that divides the spatial regions of an embryo into serially repeated regions." [GOC:dph, GOC:isa_complete, GOC:ma] comment: Note that examples of periodic partitions are tagmata, segments or parasegments. is_a: GO:0003002 ! regionalization relationship: part_of GO:0007350 ! blastoderm segmentation [Term] id: GO:0007366 name: periodic partitioning by pair rule gene namespace: biological_process def: "Allocation of cells to parasegments in the embryo, through the action of overlapping series of pair rule gene activities." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007367 name: segment polarity determination namespace: biological_process def: "Division of the 14 parasegments of the embryo into anterior and posterior compartments; exemplified by the actions of the segment polarity gene products." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0632030488, ISBN:0879694238] is_a: GO:0007365 ! periodic partitioning [Term] id: GO:0007368 name: determination of left/right symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to the left and right halves. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:dph, GOC:jid] is_a: GO:0009855 ! determination of bilateral symmetry [Term] id: GO:0007369 name: gastrulation namespace: biological_process def: "A complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals. The details of gastrulation vary from species to species, but usually result in the formation of the three primary germ layers, ectoderm, mesoderm and endoderm." [http://cancerweb.ncl.ac.uk/] xref: Wikipedia:Gastrulation is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0007370 name: ventral furrow formation namespace: biological_process def: "Formation of a ventral indentation (furrow) from the blastoderm epithelium, which is internalized to form a tube in the interior of the embryo, marking the start of gastrulation." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007371 name: ventral midline determination namespace: biological_process def: "The regionalization process by which the area where the ventral furrow will begin invagination is specified." [GOC:dph, GOC:isa_complete] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007370 ! ventral furrow formation [Term] id: GO:0007372 name: determination of anterior border of ventral midline namespace: biological_process is_a: GO:0007371 ! ventral midline determination [Term] id: GO:0007373 name: determination of posterior border of ventral midline namespace: biological_process is_a: GO:0007371 ! ventral midline determination [Term] id: GO:0007374 name: posterior midgut invagination namespace: biological_process def: "Formation of a cup-shaped invagination at the posterior end of the embryo, bringing the posterior midgut and hindgut primordia into the interior." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis is_a: GO:0060571 ! morphogenesis of an epithelial fold relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007375 name: anterior midgut invagination namespace: biological_process def: "Internalization of the anterior midgut into the interior of the embryo." [ISBN:08795694238] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007376 name: cephalic furrow formation namespace: biological_process def: "Formation of a partial necklace of inturning tissue on the lateral sides of the embryo, along the dorsal-ventral axis. This furrow demarcates head from thorax in the developing protostome." [ISBN:08795694238] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007377 name: germ-band extension namespace: biological_process def: "Elongation of the germ band on the ventral side of the embryo, accompanied by a halving in width. The elongation process pushes the posterior midgut invagination closed and compresses the amnioserosa further." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007378 name: amnioserosa formation namespace: biological_process def: "Formation of the amnioserosa, an epithelium that occupies a hole in the embryonic dorsal epidermis. This occurs by the transformation of a narrow strip of cells at the dorsal midline of the blastoderm from columnar to squamous cells, accompanied by a lateral shift." [ISBN:08795694238] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0010004 ! gastrulation involving germ band extension [Term] id: GO:0007379 name: segment specification namespace: biological_process def: "The process whereby segments assume individual identities; exemplified in insects by the actions of the products of the homeotic genes." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0035282 ! segmentation [Term] id: GO:0007380 name: specification of segmental identity, head namespace: biological_process def: "The specification of the characteristic structures of the head segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0007379 ! segment specification relationship: part_of GO:0035287 ! head segmentation [Term] id: GO:0007381 name: specification of segmental identity, labial segment namespace: biological_process def: "The specification of the characteristic structures of the labial segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'labial segment ; FBbt:00000014'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007382 name: specification of segmental identity, maxillary segment namespace: biological_process def: "The specification of the characteristic structures of the maxillary segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'maxillary segment ; FBbt:00000013'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035289 ! posterior head segmentation [Term] id: GO:0007383 name: specification of segmental identity, antennal segment namespace: biological_process def: "The specification of the characteristic structures of the antennal segment following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] comment: See also the fly_anatomy.ontology term 'antennal segment ; FBbt:00000009'. is_a: GO:0007380 ! specification of segmental identity, head relationship: part_of GO:0035288 ! anterior head segmentation [Term] id: GO:0007384 name: specification of segmental identity, thorax namespace: biological_process def: "The specification of the characteristic structures of the thoracic segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007385 name: specification of segmental identity, abdomen namespace: biological_process def: "The specification of the characteristic structures of the abdominal segments following establishment of segment boundaries. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [ISBN:0878932437] is_a: GO:0035292 ! specification of segmental identity, trunk [Term] id: GO:0007386 name: compartment pattern formation namespace: biological_process def: "The regionalization process by which embryonic segments are divided into compartments that will result in differences in cell differentiation." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "compartment specification" RELATED [GOC:dph] is_a: GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0007387 name: anterior compartment pattern formation namespace: biological_process def: "The process giving rise to specification of cell identity in the anterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior compartment pattern specification" RELATED [GOC:dph] is_a: GO:0007386 ! compartment pattern formation [Term] id: GO:0007388 name: posterior compartment specification namespace: biological_process def: "The process involved in the specification of cell identity in the posterior compartments of the segmented embryo." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0007386 ! compartment pattern formation [Term] id: GO:0007389 name: pattern specification process namespace: biological_process def: "Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate." [GOC:go_curators, GOC:isa_complete, ISBN:0521436125] synonym: "pattern biosynthesis" RELATED [] synonym: "pattern formation" RELATED [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007390 name: germ-band shortening namespace: biological_process def: "The spreading of the amnioserosa from its compressed state to cover the whole of the dorsal surface. Initiating in the thorax and spreading posteriorly, it is accompanied by the transition from a parasegmental to segmental division of the embryo." [GOC:bf, PMID:12147138] synonym: "germ-band retraction" EXACT [] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007391 name: dorsal closure namespace: biological_process def: "The process during Drosophila embryogenesis whereby the ectodermal cells of the lateral epithelium stretch in a coordinated fashion to internalize the amnioserosa cells and close the embryo dorsally." [PMID:9224720] is_a: GO:0016331 ! morphogenesis of embryonic epithelium relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007392 name: initiation of dorsal closure namespace: biological_process def: "Events that occur at the start of dorsal closure." [GOC:bf] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007393 name: dorsal closure, leading edge cell fate determination namespace: biological_process def: "Process by which a cell within the dorsal ectoderm becomes capable of differentiating autonomously into a leading edge cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:bf, GOC:go_curators, PMID:12147138] is_a: GO:0035028 ! leading edge cell fate determination relationship: part_of GO:0035029 ! dorsal closure, leading edge cell fate commitment [Term] id: GO:0007394 name: dorsal closure, elongation of leading edge cells namespace: biological_process def: "The change in shape of cells at the dorsal-most (leading) edge of the epidermis from being polygonal to being elongated in the dorsal/ventral axis." [PMID:12147138] is_a: GO:0009826 ! unidimensional cell growth is_a: GO:0016476 ! regulation of embryonic cell shape is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007392 ! initiation of dorsal closure [Term] id: GO:0007395 name: dorsal closure, spreading of leading edge cells namespace: biological_process def: "Dorsally-directed movement of a cell at the leading edge of the epithelium over the amnioserosa." [GOC:bf, PMID:12147138] is_a: GO:0016477 ! cell migration relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007396 name: suture of dorsal opening namespace: biological_process def: "Closure of the dorsal hole. Filopodia extending from each leading edge interdigitate at the dorsal midline and appear to prime the formation of adherens junctions between the two rows of leading edge cells. Newly formed septate junctions are also used to seal the dorsal hole." [GOC:bf, PMID:12147138] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0007391 ! dorsal closure [Term] id: GO:0007397 name: histogenesis and organogenesis namespace: biological_process def: "OBSOLETE. The generation of organized tissues or of whole organs." [GOC:ems] comment: This term was made obsolete because more appropriate terms were created. is_obsolete: true consider: GO:0009887 consider: GO:0009888 [Term] id: GO:0007398 name: ectoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the ectoderm over time, from its formation to the mature structure. In animal embryos, the ectoderm is the outer germ layer of the embryo, formed during gastrulation." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007399 name: nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state." [GOC:dgh] synonym: "pan-neural process" RELATED [] is_a: GO:0048731 ! system development [Term] id: GO:0007400 name: neuroblast fate determination namespace: biological_process alt_id: GO:0007408 alt_id: GO:0043347 alt_id: GO:0043348 def: "Process by which a cell becomes capable of differentiating autonomously into a neuroblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. An example of this process is found in Mus musculus." [GOC:go_curators] synonym: "neuroblast cell fate determination" EXACT [] synonym: "neuroblast identity determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0014017 ! neuroblast fate commitment [Term] id: GO:0007401 name: pan-neural process namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because its meaning is ambiguous. is_obsolete: true consider: GO:0007399 consider: GO:0050877 [Term] id: GO:0007402 name: ganglion mother cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a ganglion mother cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators] is_a: GO:0001709 ! cell fate determination [Term] id: GO:0007403 name: glial cell fate determination namespace: biological_process alt_id: GO:0043361 def: "Process by which a cell becomes capable of differentiating autonomously into a glial cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0021781 ! glial cell fate commitment [Term] id: GO:0007405 name: neuroblast proliferation namespace: biological_process alt_id: GO:0043349 alt_id: GO:0043350 def: "The expansion of a neuroblast population by cell division. A neuroblast is any cell that will divide and give rise to a neuron." [GOC:ai, GOC:mtg_sensu, GOC:sart] is_a: GO:0008283 ! cell proliferation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007406 name: negative regulation of neuroblast proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the proliferation of neuroblasts." [GOC:ai] synonym: "down regulation of neuroblast proliferation" EXACT [] synonym: "down-regulation of neuroblast proliferation" EXACT [] synonym: "downregulation of neuroblast proliferation" EXACT [] synonym: "inhibition of neuroblast proliferation" NARROW [] synonym: "suppression of neuroblast proliferation" EXACT [] is_a: GO:0008285 ! negative regulation of cell proliferation is_a: GO:0050768 ! negative regulation of neurogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007405 ! neuroblast proliferation relationship: negatively_regulates GO:0007405 ! neuroblast proliferation [Term] id: GO:0007407 name: neuroblast activation namespace: biological_process alt_id: GO:0043351 alt_id: GO:0043352 def: "A change in the morphology or behavior of a neuroblast resulting from exposure to an activating factor such as a cellular or soluble ligand." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001775 ! cell activation relationship: part_of GO:0048699 ! generation of neurons [Term] id: GO:0007409 name: axonogenesis namespace: biological_process alt_id: GO:0007410 def: "Generation of a long process of a neuron, that carries efferent (outgoing) action potentials from the cell body towards target cells." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "axon growth" NARROW [] synonym: "neuron long process generation" EXACT systematic_synonym [] is_a: GO:0048812 ! neuron projection morphogenesis relationship: part_of GO:0048667 ! cell morphogenesis involved in neuron differentiation [Term] id: GO:0007411 name: axon guidance namespace: biological_process alt_id: GO:0008040 def: "The process by which the migration of an axon growth cone is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "axon chemotaxis" RELATED [GOC:curators] synonym: "axon growth cone guidance" NARROW [] synonym: "axon pathfinding" EXACT [GOC:mah] xref: Reactome:422475 "Axon guidance" xref: Reactome:562709 "Axon guidance" xref: Reactome:588330 "Axon guidance" xref: Reactome:609074 "Axon guidance" xref: Reactome:633767 "Axon guidance" xref: Reactome:645377 "Axon guidance" xref: Reactome:655745 "Axon guidance" xref: Reactome:661191 "Axon guidance" xref: Reactome:666969 "Axon guidance" xref: Reactome:673104 "Axon guidance" xref: Reactome:678804 "Axon guidance" xref: Reactome:683732 "Axon guidance" xref: Reactome:689949 "Axon guidance" xref: Reactome:701724 "Axon guidance" xref: Reactome:716301 "Axon guidance" xref: Reactome:728244 "Axon guidance" xref: Reactome:731080 "Axon guidance" xref: Wikipedia:Axon_guidance is_a: GO:0006928 ! cellular component movement relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007412 name: axon target recognition namespace: biological_process def: "The process by which an axon recognizes and binds to a set of cells with which it may form stable connections." [ISBN:0878932437] is_a: GO:0007154 ! cell communication relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007413 name: axonal fasciculation namespace: biological_process def: "The collection of axons into a bundle of rods, known as a fascicle." [GOC:dgh] synonym: "fasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007414 name: axonal defasciculation namespace: biological_process def: "Separation of axons away from a bundle of axons known as a fascicle." [GOC:dgh, ISBN:039751820X] synonym: "defasciculation of neuron" RELATED [] is_a: GO:0008038 ! neuron recognition relationship: part_of GO:0007409 ! axonogenesis [Term] id: GO:0007415 name: defasciculation of motor neuron axon namespace: biological_process def: "Separation of a motor axon away from a bundle of axons known as a fascicle." [GOC:dgh] is_a: GO:0007414 ! axonal defasciculation [Term] id: GO:0007416 name: synapse assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a synapse." [GOC:mah] synonym: "synapse biogenesis" EXACT [GOC:mah] synonym: "synaptogenesis" EXACT [GOC:mah] xref: Wikipedia:Synaptogenesis is_a: GO:0022607 ! cellular component assembly is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007417 name: central nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain, spinal cord and spinal nerves. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord." [GOC:bf, GOC:jid, ISBN:0582227089] synonym: "CNS development" EXACT [] xref: Wikipedia:Neural_development is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007418 name: ventral midline development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral midline over time, from its formation to the mature structure. In protostomes (such as insects, snails and worms) as well as deuterostomes (vertebrates), the midline is an embryonic region that functions in patterning of the adjacent nervous tissue. The ventral midline in insects is a cell population extending along the ventral surface of the embryo and is the region from which cells detach to form the ventrally located nerve cords. In vertebrates, the midline is originally located dorsally. During development, it folds inwards and becomes the ventral part of the dorsally located neural tube and is then called the ventral midline, or floor plate." [GOC:bf, GOC:go_curators, PMID:12075342] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007419 name: ventral cord development namespace: biological_process def: "The process whose specific outcome is the progression of the ventral cord over time, from its formation to the mature structure. The ventral cord is one of the distinguishing traits of the central nervous system of all arthropods (such as insects, crustaceans and arachnids) as well as many other invertebrates, such as the annelid worms." [GOC:bf, GOC:go_curators, http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/S/Spemann.html] is_a: GO:0048513 ! organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007420 name: brain development namespace: biological_process def: "The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.)." [GOC:dph, GOC:jid, GOC:tb, http://cancerweb.ncl.ac.uk] is_a: GO:0048513 ! organ development relationship: part_of GO:0007417 ! central nervous system development [Term] id: GO:0007421 name: stomatogastric nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatogastric nervous system over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007422 name: peripheral nervous system development namespace: biological_process def: "The process whose specific outcome is the progression of the peripheral nervous system over time, from its formation to the mature structure. The peripheral nervous system is one of the two major divisions of the nervous system. Nerves in the PNS connect the central nervous system (CNS) with sensory organs, other organs, muscles, blood vessels and glands." [GOC:go_curators, http://cancerweb.ncl.ac.uk] is_a: GO:0048731 ! system development relationship: part_of GO:0007399 ! nervous system development [Term] id: GO:0007423 name: sensory organ development namespace: biological_process def: "The process whose specific outcome is the progression of sensory organs over time, from its formation to the mature structure." [GOC:go_curators] synonym: "sense organ development" EXACT [GOC:dph] is_a: GO:0048513 ! organ development [Term] id: GO:0007424 name: open tracheal system development namespace: biological_process def: "The process whose specific outcome is the progression of an open tracheal system over time, from its formation to the mature structure. An open tracheal system is a respiratory system, a branched network of epithelial tubes that supplies oxygen to target tissues via spiracles. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:8625828] comment: See also the fly_anatomy.ontology term 'tracheal system ; FBbt:00005024'. is_a: GO:0060541 ! respiratory system development [Term] id: GO:0007425 name: epithelial cell fate determination, open tracheal system namespace: biological_process alt_id: GO:0046846 def: "Process by which a cell becomes capable of differentiating autonomously into an epithelial cell within an open tracheal system regardless of its environment; upon determination, the cell fate cannot be reversed. Tracheal cells are set aside as 10 clusters of approximately 80 cells on each side of the embryo (termed tracheal placodes). An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11063940] synonym: "tracheal cell fate determination" BROAD [] synonym: "tracheal epithelial cell fate determination" EXACT [] synonym: "tracheal placode cell fate determination" RELATED [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007426 name: tracheal outgrowth, open tracheal system namespace: biological_process def: "The projection of branches of an open tracheal system towards their target tissues. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] is_a: GO:0035239 ! tube morphogenesis relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007427 name: epithelial cell migration, open tracheal system namespace: biological_process def: "The orderly movement of epithelial cells during development of an open tracheal system. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu] synonym: "tracheal cell migration" BROAD [] synonym: "tracheal epithelial cell migration" RELATED [] is_a: GO:0010631 ! epithelial cell migration relationship: part_of GO:0007424 ! open tracheal system development [Term] id: GO:0007428 name: primary branching, open tracheal system namespace: biological_process def: "Formation of primary branches in the open tracheal system. These form from small groups of cells that migrate out at specific positions, organizing into tubes as they migrate. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "primary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007429 name: secondary branching, open tracheal system namespace: biological_process def: "Sprouting of secondary branches in an open tracheal system. These form from the tips of primary branches and are formed by individual cells that roll up into unicellular tubes. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "secondary tracheal branching" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007430 name: terminal branching, open tracheal system namespace: biological_process def: "Formation of terminal branches in the open tracheal system. These are long cytoplasmic extensions that form fine tubules that transport oxygen directly to the tissues. An example of the process is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cmgm.stanford.edu/krasnow/research.html] synonym: "terminal branching of trachea, cytoplasmic projection extension" EXACT [] is_a: GO:0060446 ! branching involved in open tracheal system development [Term] id: GO:0007431 name: salivary gland development namespace: biological_process def: "The process whose specific outcome is the progression of the salivary gland over time, from its formation to the mature structure. Salivary glands include any of the saliva-secreting exocrine glands of the oral cavity." [GOC:jid, http://cancerweb.ncl.ac.uk] is_a: GO:0048732 ! gland development relationship: part_of GO:0035272 ! exocrine system development [Term] id: GO:0007432 name: salivary gland boundary specification namespace: biological_process def: "Determination of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [PMID:11598957] synonym: "salivary gland determination" EXACT [] is_a: GO:0010160 ! formation of organ boundary relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007433 name: larval salivary gland boundary specification namespace: biological_process def: "Determination in a larval organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007434 name: adult salivary gland boundary specification namespace: biological_process def: "Determination in an adult organism of where the salivary gland forms, the total number of salivary gland cells and how many cells are allocated to each of the specialised cell types within the salivary gland." [GOC:tb, PMID:11598957] synonym: "larval salivary gland determination" BROAD [GOC:tb] is_a: GO:0007432 ! salivary gland boundary specification [Term] id: GO:0007435 name: salivary gland morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] is_a: GO:0022612 ! gland morphogenesis relationship: part_of GO:0007431 ! salivary gland development [Term] id: GO:0007436 name: larval salivary gland morphogenesis namespace: biological_process def: "The process, occurring in the larva, by which the anatomical structures of the salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] is_a: GO:0007435 ! salivary gland morphogenesis is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007437 name: adult salivary gland morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the adult salivary gland are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] is_a: GO:0007435 ! salivary gland morphogenesis [Term] id: GO:0007438 name: oenocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the oenocyte over time, from its formation to the mature structure. The oenocytes are large secretory cells found in clusters underlying the epidermis of larval abdominal segments." [GOC:bf, PMID:11171397] is_a: GO:0048468 ! cell development relationship: part_of GO:0001742 ! oenocyte differentiation [Term] id: GO:0007439 name: ectodermal digestive tract development namespace: biological_process def: "The process whose specific outcome is the progression of the ectodermal digestive tract over time, from its formation to the mature structure. The ectodermal digestive tract includes those portions that are derived from ectoderm." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "ectodermal gut development" RELATED [GOC:dph] is_a: GO:0048729 ! tissue morphogenesis relationship: part_of GO:0048565 ! digestive tract development [Term] id: GO:0007440 name: foregut morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the foregut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007441 name: anterior midgut (ectodermal) morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the anterior midgut (ectodermal) are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] is_a: GO:0002009 ! morphogenesis of an epithelium relationship: part_of GO:0048567 ! ectodermal digestive tract morphogenesis [Term] id: GO:0007442 name: hindgut morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the hindgut are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048546 ! digestive tract morphogenesis [Term] id: GO:0007443 name: Malpighian tubule morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the Malpighian tubule are generated and organized. This process takes place entirely during the embryonic phase. Morphogenesis pertains to the creation of form. A Malpighian tubule is a fine, thin-walled excretory tubule in insects which leads into the posterior part of the gut." [GOC:bf, ISBN:0582227089] comment: See also the fly_anatomy.ontology term 'Malpighian tubule ; FBbt:00005786'. is_a: GO:0035239 ! tube morphogenesis is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0048619 ! embryonic hindgut morphogenesis [Term] id: GO:0007444 name: imaginal disc development namespace: biological_process def: "The process whose specific outcome is the progression of the imaginal disc over time, from its formation to the metamorphosis to form adult structures. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.)." [GOC:bf, http://cancerweb.ncl.ac.uk/] is_a: GO:0048513 ! organ development [Term] id: GO:0007445 name: determination of imaginal disc primordium namespace: biological_process def: "Allocation of embryonic cells to the imaginal disc founder populations, groups of cells that are committed to contribute to the formation of an imaginal disc compartment." [ISBN:0879694238] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007446 name: imaginal disc growth namespace: biological_process def: "The increase in mass of imaginal discs by cell proliferation prior to metamorphosis. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult structures (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:bf, GOC:jid, PMID:10679387] is_a: GO:0035265 ! organ growth is_a: GO:0048589 ! developmental growth relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007447 name: imaginal disc pattern formation namespace: biological_process def: "The regionalization process that results in defined areas of the imaginal disc that will undergo specific cell differentaiton. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:dph, GOC:isa_complete, GOC:jid] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007444 ! imaginal disc development [Term] id: GO:0007448 name: anterior/posterior pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis of the imaginal disc. Imaginal discs are epithelial infoldings in the larvae of holometabolous insects that rapidly develop into adult appendages during metamorphosis from larval to adult form." [GOC:bf, http://cancerweb.ncl.ac.uk] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0007449 name: proximal/distal pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, http://cancerweb.ncl.ac.uk] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0007450 name: dorsal/ventral pattern formation, imaginal disc namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis of the imaginal disc. Imaginal disks are masses of hypodermic cells, carried by the larvae of some insects after leaving the egg, from which masses the wings and legs of the adult are subsequently formed." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "dorsal-ventral pattern formation, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral pattern formation, imaginal disc" EXACT [GOC:mah] is_a: GO:0007447 ! imaginal disc pattern formation is_a: GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0007451 name: dorsal/ventral lineage restriction, imaginal disc namespace: biological_process def: "Formation and/or maintenance of a lineage boundary between dorsal and ventral compartments that cells cannot cross, thus separating the populations of cells in each compartment." [GOC:bf, PMID:10625531, PMID:9374402] synonym: "dorsal-ventral lineage restriction, imaginal disc" EXACT [GOC:mah] synonym: "dorsoventral lineage restriction, imaginal disc" EXACT [GOC:mah] is_a: GO:0035161 ! imaginal disc lineage restriction relationship: part_of GO:0007450 ! dorsal/ventral pattern formation, imaginal disc [Term] id: GO:0007453 name: clypeo-labral disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the clypeo-labral disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a clypeo-labal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the labrum, anterior and posterior cibarial plates, fish trap bristles, epistomal sclerite and clypeus." [GOC:bf, ISBN:0879694238] synonym: "clypeo-labral disc metamorphosis" EXACT [] synonym: "morphogenesis of structures derived from the clypeo-labral disc" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035213 ! clypeo-labral disc development [Term] id: GO:0007454 name: labial disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the labial disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a labial imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including parts of the proboscis." [GOC:bf, ISBN:0879694238] synonym: "labial disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035217 ! labial disc development [Term] id: GO:0007455 name: eye-antennal disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the eye-antennal disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of an eye-antennal imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the eye, antenna, head capsule and maxillary palps." [GOC:bf, ISBN:0879694238] synonym: "eye-antennal disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007458 name: progression of morphogenetic furrow involved in compound eye morphogenesis namespace: biological_process def: "The morphogenetic furrow is a dorsoventral indentation which sweeps anteriorly across the eye disc. Ommatidia begin to form along the furrow, resulting in a graded series of ommatidial development across the anterior/posterior axis of the disc." [PMID:3076112, PMID:3937883] synonym: "progression of morphogenetic furrow during compound eye morphogenesis" RELATED [GOC:dph, GOC:tb] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0007460 name: R8 cell fate commitment namespace: biological_process alt_id: GO:0007461 def: "The process whereby the R8 photoreceptor commits to its cell fate. The R8 receptor contributes the central part of the rhabdomere in the basal parts of the ommatidium." [PMID:3076112, PMID:3937883] synonym: "restriction of R8 fate" EXACT [] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045465 ! R8 cell differentiation [Term] id: GO:0007462 name: R1/R6 cell fate commitment namespace: biological_process def: "The process whereby the R1/R6 photoreceptors commit to their cell fate. R1 and R6 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048052 ! R1/R6 cell differentiation [Term] id: GO:0007463 name: R2/R5 cell fate commitment namespace: biological_process def: "The process whereby the R2/R5 photoreceptors commit to their cell fate. R2 and R5 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0048054 ! R2/R5 cell differentiation [Term] id: GO:0007464 name: R3/R4 cell fate commitment namespace: biological_process def: "The process whereby the R3/R4 photoreceptors commit to their cell fate. R3 and R4 are paired photoreceptors which contribute the outer rhabdomeres." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0042067 ! establishment of ommatidial planar polarity relationship: part_of GO:0048056 ! R3/R4 cell differentiation [Term] id: GO:0007465 name: R7 cell fate commitment namespace: biological_process def: "The process whereby the R7 photoreceptor commits to its cell fate. The R7 receptor contributes the central part of the rhabdomere in the apical parts of the ommatidium." [PMID:3076112, PMID:3937883] is_a: GO:0001752 ! compound eye photoreceptor fate commitment relationship: part_of GO:0045466 ! R7 cell differentiation [Term] id: GO:0007468 name: regulation of rhodopsin gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of rhodopsin gene expression. This includes transcriptional, translational, or posttranslational regulation." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of rhodopsin gene activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010468 ! regulation of gene expression relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0007469 name: antennal development namespace: biological_process def: "The process whose specific outcome is the progression of the antenna over time, from its formation to the mature structure. The antenna are the sensory structures on the head that are capable of detecting various environmental stimuli." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004526] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0007470 name: prothoracic disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the prothoracic disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a prothoracic imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult humerous and anterior spiracle." [GOC:bf, ISBN:0879694238] synonym: "prothoracic disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis is_a: GO:0035219 ! prothoracic disc development is_a: GO:0048569 ! post-embryonic organ development [Term] id: GO:0007471 name: prothoracic morphogenesis namespace: biological_process def: "OBSOLETE. The process by which the anatomical structures of the first or anterior segment of the insect thorax are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] comment: This term was made obsolete because it does not stipulate which anatomical part is involved in the process. is_obsolete: true consider: GO:0007470 [Term] id: GO:0007472 name: wing disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the wing disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a wing imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the wing hinge, wing blade and pleura." [GOC:bf, ISBN:0879694238] synonym: "wing disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007473 name: wing disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the wing disc, a precursor to the adult wing." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035222 ! wing disc pattern formation [Term] id: GO:0007474 name: imaginal disc-derived wing vein specification namespace: biological_process def: "The regionalization process by which the area of a imaginal disc-derived wing that will form a wing vein is specified." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu] synonym: "wing vein specification" EXACT [] is_a: GO:0003002 ! regionalization relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0007475 name: apposition of dorsal and ventral imaginal disc-derived wing surfaces namespace: biological_process def: "The coming together of the dorsal and ventral surfaces of the imaginal disc-derived wing during the conversion of a folded single layered wing disc to a flat bilayered wing." [GOC:bf, GOC:mtg_sensu] synonym: "apposition of dorsal and ventral wing surfaces" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0008587 ! imaginal disc-derived wing margin morphogenesis [Term] id: GO:0007476 name: imaginal disc-derived wing morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form. The wing is an appendage modified for flying." [GOC:bf, GOC:mtg_sensu] synonym: "wing morphogenesis" EXACT [] is_a: GO:0035114 ! imaginal disc-derived appendage morphogenesis is_a: GO:0035120 ! post-embryonic appendage morphogenesis relationship: part_of GO:0007472 ! wing disc morphogenesis [Term] id: GO:0007477 name: notum development namespace: biological_process def: "The process whose specific outcome is the progression of the dorsal part of the body over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035220 ! wing disc development [Term] id: GO:0007478 name: leg disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the leg disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a leg imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into recognizable adult structures including the leg, coxa and ventral thoracic pleura." [GOC:bf, ISBN:0879694238] synonym: "leg disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035218 ! leg disc development [Term] id: GO:0007479 name: leg disc proximal/distal pattern formation namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis of the leg imaginal disc, a precursor to the adult leg." [GOC:bf] is_a: GO:0007449 ! proximal/distal pattern formation, imaginal disc is_a: GO:0035223 ! leg disc pattern formation [Term] id: GO:0007480 name: imaginal disc-derived leg morphogenesis namespace: biological_process def: "The process by which the anatomical structures of a leg derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. A leg is a limb on which an animal walks and stands. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, http://cancerweb.ncl.ac.uk/] is_a: GO:0035109 ! imaginal disc-derived limb morphogenesis is_a: GO:0035110 ! leg morphogenesis is_a: GO:0035127 ! post-embryonic limb morphogenesis relationship: part_of GO:0007478 ! leg disc morphogenesis [Term] id: GO:0007481 name: haltere disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the haltere disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a haltere imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult capitellum, pedicel, haltere sclerite, metathoracic spiracle and metanotum." [GOC:bf, ISBN:0879694238] synonym: "haltere disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007482 name: haltere development namespace: biological_process def: "The process whose specific outcome is the progression of the haltere over time, from its formation to the mature structure. The haltere is the club-shaped 'balancers' found on each side of the metathorax among the true flies (Diptera). They are the much-modified hind wings." [GOC:jid, http://www.earthlife.net] is_a: GO:0048737 ! imaginal disc-derived appendage development relationship: part_of GO:0035216 ! haltere disc development [Term] id: GO:0007483 name: genital disc morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the genital disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of a genital imaginal disc from a monolayered epithelium in the larvae of holometabolous insects into the recognizable adult genital structures, the anal plates and the hind gut." [GOC:bf, ISBN:0879694238] synonym: "genital disc metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007484 name: imaginal disc-derived genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "genital development" BROAD [] is_a: GO:0048806 ! genitalia development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007485 name: imaginal disc-derived male genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the male genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "male genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development [Term] id: GO:0007486 name: imaginal disc-derived female genitalia development namespace: biological_process def: "The process whose specific outcome is the progression of the female genitalia over time, from formation as part of the genital disc to the mature structure. An example of this is found in Drosophila melanogaster." [GOC:ai, GOC:sensu] synonym: "female genital development" BROAD [] is_a: GO:0007484 ! imaginal disc-derived genitalia development is_a: GO:0030540 ! female genitalia development [Term] id: GO:0007487 name: analia development namespace: biological_process def: "The process whose specific outcome is the progression of the analia over time, from its formation to the mature structure. The analia is the posterior-most vertral appendage that develops from the genital disc. An example of this process is analia development in Drosophila melanogaster." [GOC:ai, GOC:mtg_sensu] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035215 ! genital disc development [Term] id: GO:0007488 name: histoblast morphogenesis namespace: biological_process def: "The process by which the anatomical structures derived from the histoblast disc are generated and organized. Morphogenesis pertains to the creation of form. This includes the transformation of histoblast cells into adult structures during pupal metamorphosis. Histoblast cells are cells founded in the embryo that are the progenitors to the adult abdomen." [GOC:bf, ISBN:0879694238] synonym: "histoblast metamorphosis" EXACT [] is_a: GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007489 name: maintenance of imaginal histoblast diploidy namespace: biological_process def: "The negative regulation of the differentiation of polytenized larval hypodermal cells from abdominal histoblasts. The abdominal histoblasts remain a small cluster of diploid cells among the polytenized larval hypodermal cells." [GOC:bf, ISBN:0879694238] is_a: GO:0045596 ! negative regulation of cell differentiation relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007490 name: tergite morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the tergite are generated and organized. Morphogenesis pertains to the creation of form. The tergite is the primary plate or sclerite forming the dorsal surface of any insect body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007491 name: sternite morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the sternite are generated and organized. Morphogenesis pertains to the creation of form. The sternite is the plate or sclerite on the underside of a body segment." [GOC:jid, http://www.earthlife.net] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007488 ! histoblast morphogenesis [Term] id: GO:0007492 name: endoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the endoderm over time, from its formation to the mature structure. The endoderm is the innermost germ layer that develops into the gastrointestinal tract, the lungs and associated tissues." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007493 name: endodermal cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into an endoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'endoderm determination'. Changed string to make it more consistent with parent term 'cell fate determination'. synonym: "endoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001711 ! endodermal cell fate commitment [Term] id: GO:0007494 name: midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the midgut over time, from its formation to the mature structure. The midgut is the middle part of the alimentary canal from the stomach, or entrance of the bile duct, to, or including, the large intestine." [GOC:jid, http://cancerweb.ncl.ac.uk] is_a: GO:0048565 ! digestive tract development [Term] id: GO:0007495 name: visceral mesoderm-endoderm interaction involved in midgut development namespace: biological_process def: "The process of cell-cell signaling between visceral mesoderm cells and endoderm cells that is involved in the differentiation of cells in the midgut." [GOC:dph, GOC:isa_complete] synonym: "visceral mesoderm/endoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007496 name: anterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the anterior midgut over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007497 name: posterior midgut development namespace: biological_process def: "The process whose specific outcome is the progression of the posterior midgut over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0007494 ! midgut development [Term] id: GO:0007498 name: mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the mesoderm over time, from its formation to the mature structure. The mesoderm is the middle germ layer that develops into muscle, bone, cartilage, blood and connective tissue." [GOC:dph, GOC:tb] is_a: GO:0009888 ! tissue development [Term] id: GO:0007499 name: ectoderm and mesoderm interaction namespace: biological_process def: "A cell-cell signaling process occurring between the two gastrulation-generated layers of the ectoderm and the mesoderm." [GOC:isa_complete] synonym: "ectoderm/mesoderm interaction" EXACT [] is_a: GO:0007267 ! cell-cell signaling relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007500 name: mesodermal cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell regardless of its environment; upon determination, the cell fate cannot be reversed." [GOC:go_curators, ISBN:0878932437] comment: Note that this term was 'mesoderm determination'. Changed string to make more consistent with parent term 'cell fate determination'. synonym: "mesoderm cell fate determination" EXACT [] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007501 name: mesodermal cell fate specification namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a mesoderm cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:go_curators] comment: Note that this term was 'fate specification in mesoderm'. String of term was changed to correspond to format of sibling terms 'endoderm cell fate specification' and 'ectoderm cell fate specification'. synonym: "mesoderm cell fate specification" EXACT [] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0001710 ! mesodermal cell fate commitment [Term] id: GO:0007502 name: digestive tract mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the digestive tract mesoderm over time, from its formation to the mature structure. The digestive tract mesoderm is portion of the middle layer of the three primary germ layers of the embryo which will go on to form part of the digestive tract of the organism." [GOC:ai] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007498 ! mesoderm development [Term] id: GO:0007503 name: fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the fat body over time, from its formation to the mature structure. A fat body is an insect gland dorsal to the insect gut, with a function analogous to that of the vertebrate liver. It is a storage organ for fats, glycogen and protein and is a major site of intermediary metabolism." [ISBN:0582227089] is_a: GO:0048513 ! organ development [Term] id: GO:0007504 name: larval fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the larval fat body over time, from its formation to the mature structure. The larval fat body consists of a bilaterally symmetrical monolayer of cells lying between the gut and the muscles of the body wall. As in other tissues of the larva, the cells of the fat body complete their divisions in the embryo and increase in size and ploidy during larval life." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0007505 name: adult fat body development namespace: biological_process def: "The process whose specific outcome is the progression of the adult fat body over time, from its formation to the mature structure. Larval fat body cells that remain at eclosion degenerate in the first 2 to 4 days of adult life, leaving behind the smaller cells of the adult fat body." [GOC:bf, ISBN:0879694238] is_a: GO:0007503 ! fat body development [Term] id: GO:0007506 name: gonadal mesoderm development namespace: biological_process def: "The process whose specific outcome is the progression of the gonadal mesoderm over time, from its formation to the mature structure. The gonadal mesoderm is the middle layer of the three primary germ layers of the embryo which will go on to form the gonads of the organism." [GOC:ai] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0007498 ! mesoderm development relationship: part_of GO:0008406 ! gonad development [Term] id: GO:0007507 name: heart development namespace: biological_process alt_id: GO:0007511 def: "The process whose specific outcome is the progression of the heart over time, from its formation to the mature structure. The heart is a hollow, muscular organ, which, by contracting rhythmically, keeps up the circulation of the blood." [GOC:jid, http://cancerweb.ncl.ac.uk] synonym: "cardiac development" RELATED [] synonym: "dorsal vessel development" NARROW [] xref: Wikipedia:Heart_development is_a: GO:0048513 ! organ development [Term] id: GO:0007508 name: larval heart development namespace: biological_process def: "The process whose specific outcome is the progression of the larval heart over time, from its formation to the mature structure. In Drosophila the larval heart (dorsal vessel) is a continuous tube of mesodormal cells that runs beneath the dorsal midline of the epidermis, divided into an anterior aorta and a posterior heart proper." [GOC:bf, ISBN:08779694238] is_a: GO:0007507 ! heart development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007509 name: mesoderm migration namespace: biological_process def: "The migration of mesodermal cells during gastrulation to help establish the multilayered body plan of the organism." [GOC:isa_complete] is_a: GO:0090130 ! tissue migration relationship: part_of GO:0001707 ! mesoderm formation [Term] id: GO:0007510 name: cardioblast cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a cardioblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] is_a: GO:0060913 ! cardiac cell fate determination relationship: part_of GO:0042684 ! cardioblast cell fate commitment [Term] id: GO:0007512 name: adult heart development namespace: biological_process def: "The process whose specific outcome is the progression of the adult heart over time, from its formation to the mature structure." [GOC:bf] synonym: "adult cardiac development" RELATED [] is_a: GO:0007507 ! heart development [Term] id: GO:0007513 name: pericardial cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized features of a pericardial cell. In insects, pericardial cells are loosely arranged non-myogenic cells that flank the cardioblasts and probably act in the filtration of hemolymph." [GOC:bf, PMID:12435360] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0007514 name: garland cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a garland cell, a small group of nephrocytes which take up waste materials from the hemolymph by endocytosis." [PMID:7588884] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0007515 name: lymph gland development namespace: biological_process def: "OBSOLETE. The process whose specific outcome is the progression of the lymph gland over time, from its formation to the mature structure. The lymph gland is a small bean-shaped organ made up of a loose meshwork of reticular tissue in which are enmeshed large numbers of lymphocytes, macrophages and accessory cells. Lymph glands are located along the lymphatic system." [GOC:jid, http://cancerweb.ncl.ac.uk] comment: This term was made obsolete because it was wrongly defined. is_obsolete: true consider: GO:0048535 consider: GO:0048542 [Term] id: GO:0007516 name: hemocyte development namespace: biological_process def: "The process whose specific outcome is the progression of the hemocyte over time, from its formation to the mature structure. Hemocytes are blood cells associated with a hemocoel (the cavity containing most of the major organs of the arthropod body) which are involved in defense and clotting of hemolymph, but not involved in transport of oxygen." [GOC:bf, GOC:mtg_sensu] synonym: "arthropod blood cell development" EXACT [] is_a: GO:0048468 ! cell development relationship: part_of GO:0042386 ! hemocyte differentiation [Term] id: GO:0007517 name: muscle organ development namespace: biological_process def: "The process whose specific outcome is the progression of the muscle over time, from its formation to the mature structure. The muscle is an organ consisting of a tissue made up of various elongated cells that are specialized to contract and thus to produce movement and mechanical work." [GOC:jid, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048513 ! organ development is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007518 name: myoblast cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a myoblast cell regardless of its environment; upon determination, the cell fate cannot be reversed. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0048625 ! myoblast cell fate commitment [Term] id: GO:0007519 name: skeletal muscle tissue development namespace: biological_process alt_id: GO:0048637 def: "The developmental sequence of events leading to the formation of adult muscle that occurs in the anima. In vertebrate skeletal muscle the main events are: the fusion of myoblasts to form myotubes that increase in size by further fusion to them of myoblasts, the formation of myofibrils within their cytoplasm and the establishment of functional neuromuscular junctions with motor neurons. At this stage they can be regarded as mature muscle fibers." [GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/] synonym: "myogenesis" RELATED [] is_a: GO:0014706 ! striated muscle tissue development relationship: part_of GO:0060538 ! skeletal muscle organ development [Term] id: GO:0007520 name: myoblast fusion namespace: biological_process def: "A process whereby non-proliferating myoblasts fuse to existing fibers or to myotubes to form new fibers. A myoblast is a mononucleate cell type that, by fusion with other myoblasts, gives rise to the myotubes that eventually develop into skeletal muscle fibers." [CL:0000056, GOC:mtg_muscle, http://cancerweb.ncl.ac.uk/] is_a: GO:0000768 ! syncytium formation by plasma membrane fusion relationship: part_of GO:0014902 ! myotube differentiation [Term] id: GO:0007521 name: muscle cell fate determination namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into a muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed." [CL:0000187, GOC:go_curators] is_a: GO:0001709 ! cell fate determination relationship: part_of GO:0042693 ! muscle cell fate commitment [Term] id: GO:0007522 name: visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the visceral muscle over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0007517 ! muscle organ development [Term] id: GO:0007523 name: larval visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007524 name: adult visceral muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult visceral muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007522 ! visceral muscle development [Term] id: GO:0007525 name: somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the somatic muscle over time, from its formation to the mature structure. Somatic muscles are striated muscle structures that connect to the exoskeleton or cuticle." [GOC:jid, GOC:mtg_muscle] is_a: GO:0061061 ! muscle structure development [Term] id: GO:0007526 name: larval somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the larval somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development is_a: GO:0048569 ! post-embryonic organ development relationship: part_of GO:0002164 ! larval development [Term] id: GO:0007527 name: adult somatic muscle development namespace: biological_process def: "The process whose specific outcome is the progression of the adult somatic muscle over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0007525 ! somatic muscle development [Term] id: GO:0007528 name: neuromuscular junction development namespace: biological_process def: "The process whose specific outcome is the progression of the neuromuscular junction over time, from its formation to the mature structure." [GOC:jid] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0048741 ! skeletal muscle fiber development [Term] id: GO:0007529 name: establishment of synaptic specificity at neuromuscular junction namespace: biological_process def: "The biological process by which a synapse between a motor neuron and a muscle is initially formed." [GOC:isa_complete] is_a: GO:0050808 ! synapse organization relationship: part_of GO:0007528 ! neuromuscular junction development [Term] id: GO:0007530 name: sex determination namespace: biological_process def: "Any process that establishes and transmits the specification of sexual status of an individual organism." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Sex-determination_system is_a: GO:0003006 ! reproductive developmental process [Term] id: GO:0007531 name: mating type determination namespace: biological_process def: "Any process that establishes and transmits the specification of mating type upon an individual. Mating types are the equivalent in microorganisms of the sexes in higher organisms." [http://www.biology-text.com/] is_a: GO:0007530 ! sex determination is_a: GO:0045165 ! cell fate commitment is_a: GO:0048610 ! reproductive cellular process [Term] id: GO:0007532 name: regulation of transcription, mating-type specific namespace: biological_process def: "Any mating-type specific process that modulates the frequency, rate or extent of transcription." [GOC:go_curators] synonym: "mating-type specific transcriptional control" EXACT [] is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0007531 ! mating type determination [Term] id: GO:0007533 name: mating type switching namespace: biological_process def: "The conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus." [PMID:9928492] synonym: "mating type switching and recombination" RELATED [] is_a: GO:0006259 ! DNA metabolic process is_a: GO:0007531 ! mating type determination is_a: GO:0022413 ! reproductive process in single-celled organism [Term] id: GO:0007534 name: gene conversion at mating-type locus namespace: biological_process def: "The conversion of the mating-type locus from one allele to another resulting from the recombinational repair of a site-specific double-strand break at the mating-type locus with information from a silent donor sequence. There is no reciprocal exchange of information because the mating-type locus copies information from the donor sequence and the donor sequence remains unchanged." [GOC:elh, PMID:9928492] is_a: GO:0006312 ! mitotic recombination relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007535 name: donor selection namespace: biological_process def: "The process by which a cell uses one locus in preference to another as the donor in mating type switching." [GOC:mah, PMID:9928492] synonym: "donor preference" RELATED [] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0007533 ! mating type switching [Term] id: GO:0007536 name: activation of recombination (HML) namespace: biological_process def: "The activation of recombination at a mating type locus, such that it is used in preference to the other donor locus for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045911 ! positive regulation of DNA recombination [Term] id: GO:0007537 name: inactivation of recombination (HML) namespace: biological_process def: "The inactivation of recombination at sequences around a mating type donor locus, with the consequence that the other donor is the only one available for mating type switching; exemplified by the HML locus and surrounding sequences on Chromosome III in Saccharomyces cerevisiae." [GOC:mah, PMID:9928492] is_a: GO:0007535 ! donor selection is_a: GO:0045910 ! negative regulation of DNA recombination [Term] id: GO:0007538 name: primary sex determination namespace: biological_process is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007539 name: primary sex determination, soma namespace: biological_process def: "The transmission of information about sexual status from the initial, general, determination to signals specific to the soma." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018993 ! somatic sex determination [Term] id: GO:0007540 name: sex determination, establishment of X:A ratio namespace: biological_process def: "The developmental process by which an organism senses the number of X chromosomes and autosomes in its genomic complement and responds to it." [GOC:isa_complete] is_a: GO:0003006 ! reproductive developmental process relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007541 name: sex determination, primary response to X:A ratio namespace: biological_process def: "The developmental process by which an organism interprets its X to autosomal chromosomal complement." [GOC:isa_complete] is_a: GO:0003006 ! reproductive developmental process relationship: part_of GO:0007539 ! primary sex determination, soma [Term] id: GO:0007542 name: primary sex determination, germ-line namespace: biological_process def: "The transmission of information about sexual status, from the initial general determination, to signals specific to the germ-line." [GOC:ems] is_a: GO:0007538 ! primary sex determination relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007543 name: sex determination, somatic-gonadal interaction namespace: biological_process def: "The process that mediates the interactions between somatic cells and gonadal cells that ultimately results in the specification of sexual status of the organism." [GOC:isa_complete] synonym: "sex determination, somatic/gonadal interaction" EXACT [] is_a: GO:0007154 ! cell communication is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007542 ! primary sex determination, germ-line [Term] id: GO:0007545 name: processes downstream of sex determination signal namespace: biological_process is_a: GO:0007530 ! sex determination relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007546 name: somatic processes downstream of sex determination signal namespace: biological_process def: "The events determining the somatic sexual phenotype after the initial transmission of that phenotype to soma-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal [Term] id: GO:0007547 name: germ-line processes downstream of sex determination signal namespace: biological_process def: "The events determining the germ-line sexual phenotype after the initial transmission of that phenotype to germ-line-specific information pathways." [GOC:ems] is_a: GO:0007545 ! processes downstream of sex determination signal relationship: part_of GO:0018992 ! germ-line sex determination [Term] id: GO:0007548 name: sex differentiation namespace: biological_process def: "The establishment of the sex of an organism by physical differentiation." [GOC:ai] xref: Wikipedia:Sexual_differentiation is_a: GO:0003006 ! reproductive developmental process [Term] id: GO:0007549 name: dosage compensation namespace: biological_process def: "Compensating for the two-fold variation in X:autosome chromosome ratios between sexes by a global activation or inactivation of all, or most of, genes on one or both of the X chromosomes." [GOC:ems, ISBN:0140512888, PMID:11498577] xref: Wikipedia:Dosage_compensation is_a: GO:0040029 ! regulation of gene expression, epigenetic [Term] id: GO:0007550 name: establishment of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. is_obsolete: true consider: GO:0007549 [Term] id: GO:0007551 name: maintenance of dosage compensation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:isa_complete] comment: This term was made obsolete because it was undefined and because there is no common mechanism of establishment of dosage compensation in different organisms. is_obsolete: true consider: GO:0007549 [Term] id: GO:0007552 name: metamorphosis namespace: biological_process alt_id: GO:0046698 alt_id: GO:0046699 def: "A biological process by which an animal physically develops after birth or hatching, involving a conspicuous and relatively abrupt change in the animal's form or structure. Examples include the change from tadpole to frog, and the change from larva to adult. An example of this is found in Drosophila melanogaster." [GOC:sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Wikipedia:Metamorphosis is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0007553 name: regulation of ecdysteroid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving ecdysteroids, a group of polyhydroxylated ketosteroids which initiate post-embryonic development, including the metamorphosis of immature forms and the development of the reproductive system and the maturation of oocytes in adult females." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "regulation of ecdysteroid metabolism" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019218 ! regulation of steroid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045455 ! ecdysteroid metabolic process relationship: regulates GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0007554 name: regulation of ecdysteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ecdysteroids." [GOC:go_curators] synonym: "regulation of ecdysteroid anabolism" EXACT [] synonym: "regulation of ecdysteroid biosynthesis" EXACT [] synonym: "regulation of ecdysteroid formation" EXACT [] synonym: "regulation of ecdysteroid synthesis" EXACT [] is_a: GO:0007553 ! regulation of ecdysteroid metabolic process is_a: GO:0010566 ! regulation of ketone biosynthetic process is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045456 ! ecdysteroid biosynthetic process relationship: regulates GO:0045456 ! ecdysteroid biosynthetic process [Term] id: GO:0007555 name: regulation of ecdysteroid secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the regulated release of ecdysteroid from a cell or group of cells." [GOC:go_curators] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045457 ! ecdysteroid secretion relationship: regulates GO:0045457 ! ecdysteroid secretion [Term] id: GO:0007556 name: regulation of juvenile hormone metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone metabolism" EXACT [] is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0032350 ! regulation of hormone metabolic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006716 ! juvenile hormone metabolic process relationship: part_of GO:0002165 ! instar larval or pupal development relationship: regulates GO:0006716 ! juvenile hormone metabolic process [Term] id: GO:0007557 name: regulation of juvenile hormone biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of juvenile hormone." [GOC:go_curators] synonym: "regulation of juvenile hormone anabolism" EXACT [] synonym: "regulation of juvenile hormone biosynthesis" EXACT [] synonym: "regulation of juvenile hormone formation" EXACT [] synonym: "regulation of juvenile hormone synthesis" EXACT [] is_a: GO:0007556 ! regulation of juvenile hormone metabolic process is_a: GO:0046885 ! regulation of hormone biosynthetic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006718 ! juvenile hormone biosynthetic process relationship: regulates GO:0006718 ! juvenile hormone biosynthetic process [Term] id: GO:0007558 name: regulation of juvenile hormone secretion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of juvenile hormone secretion." [GOC:go_curators] is_a: GO:0044060 ! regulation of endocrine process is_a: GO:0046883 ! regulation of hormone secretion intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045443 ! juvenile hormone secretion relationship: regulates GO:0045443 ! juvenile hormone secretion [Term] id: GO:0007559 name: histolysis namespace: biological_process def: "The breakdown of tissues; usually, if not always, accompanied by cell death, followed by the complete dissolution of dead tissue." [GOC:dph, GOC:ma] xref: Wikipedia:Histolysis is_a: GO:0016271 ! tissue death relationship: part_of GO:0009888 ! tissue development [Term] id: GO:0007560 name: imaginal disc morphogenesis namespace: biological_process alt_id: GO:0007452 def: "The process by which the anatomical structures derived from an imaginal disc are generated and organized. Morphogenesis pertains to the creation of form. The imaginal discs are epithelial infoldings in the larvae of holometabolous insects that develop into adult appendages (legs, antennae, wings, etc.) during metamorphosis from larval to adult form." [GOC:jid] synonym: "imaginal disc metamorphosis" EXACT [] is_a: GO:0048563 ! post-embryonic organ morphogenesis relationship: part_of GO:0007444 ! imaginal disc development relationship: part_of GO:0007552 ! metamorphosis relationship: part_of GO:0048707 ! instar larval or pupal morphogenesis [Term] id: GO:0007561 name: imaginal disc eversion namespace: biological_process def: "The eversion (turning inside out) of imaginal discs from their peripodial sacs, resulting in movement of the epithelium to the outside of the larval epidermis." [PMID:11494317] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007560 ! imaginal disc morphogenesis [Term] id: GO:0007562 name: eclosion namespace: biological_process def: "The emergence of an adult insect from a pupa case." [GOC:dgh, GOC:dos, GOC:mah, ISBN:0198600461] xref: Wikipedia:Pupa#Emergence is_a: GO:0071684 ! organism emergence from protective structure relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0007563 name: regulation of eclosion namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the emergence of an insect from a pupa-case or of a larva from an egg." [GOC:go_curators, ISBN:0198600461] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007562 ! eclosion relationship: regulates GO:0007562 ! eclosion [Term] id: GO:0007564 name: regulation of chitin-based cuticle tanning namespace: biological_process def: "Any process that modulates the frequency, rate or extent of chitin-based cuticular tanning." [GOC:go_curators, GOC:jid, GOC:mtg_sensu] synonym: "regulation of cuticle hardening" NARROW [] synonym: "regulation of cuticle tanning" EXACT [] is_a: GO:0050793 ! regulation of developmental process is_a: GO:0051239 ! regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007593 ! chitin-based cuticle tanning relationship: regulates GO:0007593 ! chitin-based cuticle tanning [Term] id: GO:0007565 name: female pregnancy namespace: biological_process def: "The set of physiological processes that allow an embryo or foetus to develop within the body of a female animal. It covers the time from fertilization of a female ovum by a male spermatozoon until birth." [ISBN:0192800825] synonym: "carrying of young" RELATED [] synonym: "gestation" EXACT [] xref: Wikipedia:Gestation is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007566 name: embryo implantation namespace: biological_process def: "Attachment of the blastocyst to the uterine lining." [GOC:isa_complete, http://www.medterms.com] synonym: "blastocyst implantation" EXACT [] is_a: GO:0022414 ! reproductive process relationship: part_of GO:0007275 ! multicellular organismal development relationship: part_of GO:0007565 ! female pregnancy [Term] id: GO:0007567 name: parturition namespace: biological_process def: "The reproductive process in which the parent is separated from its offspring either by giving birth to live young or by laying eggs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "egg laying" NARROW [] synonym: "giving birth" EXACT [] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007568 name: aging namespace: biological_process alt_id: GO:0016280 def: "The inherent decline over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:ems] synonym: "ageing" EXACT [] xref: Wikipedia:Aging is_a: GO:0032502 ! developmental process [Term] id: GO:0007569 name: cell aging namespace: biological_process def: "Progression of the cell from its inception to the end of its lifespan." [GOC:jh, PMID:12044934] synonym: "cell ageing" EXACT [] synonym: "cellular senescence" EXACT [] xref: Wikipedia:Senescence#Cellular_senescence is_a: GO:0007568 ! aging is_a: GO:0009987 ! cellular process [Term] id: GO:0007570 name: age dependent accumulation of genetic damage namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0001301 [Term] id: GO:0007571 name: age-dependent general metabolic decline namespace: biological_process def: "The process arising as the cell progresses toward the end of its lifespan that cause changes cellular metabolism, resulting in a decline in cell function; for example, a decline in the efficiency of protein synthesis." [GOC:jh, PMID:9891807] synonym: "age-dependent decreased translational activity" NARROW [] synonym: "age-dependent increased protein content" NARROW [] synonym: "age-dependent yeast cell size increase" RELATED [] synonym: "nucleolar size increase" NARROW [] is_a: GO:0032502 ! developmental process relationship: part_of GO:0007568 ! aging [Term] id: GO:0007572 name: age dependent decreased translational activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007573 name: age dependent increased protein content namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007574 name: cell aging (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. Process associated with continued cell division (budding) by the mother cell. Age is often measured by counting the number of bud scars on the cell." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process that is distinct from 'cell aging'. is_obsolete: true replaced_by: GO:0007569 [Term] id: GO:0007575 name: nucleolar size increase namespace: biological_process def: "OBSOLETE. The process of nucleolar expansion." [GOC:ai] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 consider: GO:0007576 [Term] id: GO:0007576 name: nucleolar fragmentation namespace: biological_process alt_id: GO:0046616 synonym: "nucleolar size increase" RELATED [] is_a: GO:0007000 ! nucleolus organization relationship: part_of GO:0007569 ! cell aging [Term] id: GO:0007577 name: autophagic death (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. This process is a type of programmed cell death pathway similar to apoptosis and necrosis observed in multicellular organisms. It is characterized by cellular enlargement (necrosis) and presence of many autophagic bodies along with degradation of cellular components (nucleus, Golgi, ER), protein, DNA and RNA." [GOC:sgd_curators] comment: This term was made obsolete because a more correct term has been created. is_obsolete: true consider: GO:0048102 [Term] id: GO:0007578 name: aging dependent sterility (sensu Saccharomyces) namespace: biological_process def: "OBSOLETE. A haploid's inability to mate due to the loss of silencing at the mating-type loci, resulting in expression of both of the normally silent mating-type cassettes." [GOC:sgd_curators] comment: This term was made obsolete because it reflected a trait or phenotype. is_obsolete: true consider: GO:0030466 [Term] id: GO:0007579 name: senescence factor accumulation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jh] comment: This term was made obsolete because it does not represent a process. is_obsolete: true [Term] id: GO:0007580 name: extrachromosomal circular DNA accumulation involved in cell aging namespace: biological_process def: "Increase in abundance, as cells age, of circular DNA molecules that originate in the chromosome but are excised and circularized, often by intramolecular homologous recombination between direct tandem repeats, and replicated independently of chromosomal replication." [GOC:jh, PMID:9891807] comment: Note that the term string was changed to be consistent with placement of this term in cell aging hierarchy. synonym: "extrachromosomal circular DNA accumulation during cell ageing" RELATED [] synonym: "extrachromosomal circular DNA accumulation during cell aging" RELATED [GOC:dph, GOC:tb] is_a: GO:0001301 ! progressive alteration of chromatin involved in cell aging [Term] id: GO:0007581 name: age-dependent yeast cell size increase namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:sgd_curators] comment: This term was made obsolete because it does not describe a biological process. is_obsolete: true consider: GO:0007571 [Term] id: GO:0007583 name: killer activity namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it is ambiguous; 'killer activity' could refer to several different processes. is_obsolete: true consider: GO:0042267 [Term] id: GO:0007584 name: response to nutrient namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus." [GOC:go_curators] subset: gosubset_prok synonym: "nutritional response pathway" NARROW [] synonym: "response to nutrients" EXACT [] is_a: GO:0031667 ! response to nutrient levels is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0007585 name: respiratory gaseous exchange namespace: biological_process def: "The process of gaseous exchange between an organism and its environment. In plants, microorganisms, and many small animals, air or water makes direct contact with the organism's cells or tissue fluids, and the processes of diffusion supply the organism with dioxygen (O2) and remove carbon dioxide (CO2). In larger animals the efficiency of gaseous exchange is improved by specialized respiratory organs, such as lungs and gills, which are ventilated by breathing mechanisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "breathing" BROAD [] synonym: "respiration" BROAD [] is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007586 name: digestion namespace: biological_process def: "The whole of the physical, chemical, and biochemical processes carried out by multicellular organisms to break down ingested nutrients into components that may be easily absorbed and directed into metabolism." [GOC:isa_complete, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir xref: Wikipedia:Digestion is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007587 name: sugar utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary sugar sources, usually glucose, and then activates genes to scavenge the last traces of the primary sugar source and to transport and metabolize alternate sugar sources. The utilization process begins when the cell or organism detects sugar levels, includes the activation of genes whose products detect, transport or metabolize sugars, and ends when the sugar is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process relationship: has_part GO:0005975 ! carbohydrate metabolic process relationship: has_part GO:0008643 ! carbohydrate transport relationship: has_part GO:0009730 ! detection of carbohydrate stimulus [Term] id: GO:0007588 name: excretion namespace: biological_process def: "The elimination by an organism of the waste products that arise as a result of metabolic activity. These products include water, carbon dioxide (CO2), and nitrogenous compounds." [ISBN:0192801023] subset: goslim_pir xref: Wikipedia:Excretion is_a: GO:0003008 ! system process is_a: GO:0046903 ! secretion [Term] id: GO:0007589 name: body fluid secretion namespace: biological_process def: "The controlled release of a fluid by a cell or group of cells in a multicellular organism." [GOC:ai, GOC:dph, GOC:tb] is_a: GO:0046903 ! secretion is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007590 name: fat body metabolic process (sensu Insecta) namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving the fat body. A fat body is a fat-containing cellular structure which serves as an energy reserve. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents metabolism within the fat body not of the fat body. is_obsolete: true consider: GO:0008152 consider: GO:0015032 [Term] id: GO:0007591 name: molting cycle, chitin-based cuticle namespace: biological_process def: "The periodic shedding of part or all of a chitin-based cuticle, which is then replaced by a new cuticle. An example of this is found in Drosophila melanogaster." [GOC:jl, GOC:mtg_sensu] synonym: "chitin-based cuticle molting cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0018988 ! molting cycle, protein-based cuticle [Term] id: GO:0007592 name: protein-based cuticle development namespace: biological_process def: "Synthesis and deposition of a protein-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this is found in Caenorhabditis elegans." [GOC:ems, GOC:mtg_sensu] synonym: "protein-based cuticle anabolism" EXACT [] synonym: "protein-based cuticle biosynthetic process" EXACT [] synonym: "protein-based cuticle formation" EXACT [] synonym: "protein-based cuticle synthesis" EXACT [] is_a: GO:0042335 ! cuticle development [Term] id: GO:0007593 name: chitin-based cuticle tanning namespace: biological_process alt_id: GO:0045452 def: "The cross-linking of chitin and other cuticle proteins, rendering them insoluble and hardening the cuticle. This process generally darkens the color of the cuticle." [GOC:bf, GOC:jid, GOC:mtg_sensu] synonym: "cuticle hardening" NARROW [] is_a: GO:0021700 ! developmental maturation is_a: GO:0040006 ! protein-based cuticle attachment to epithelium relationship: part_of GO:0008365 ! adult chitin-based cuticle development [Term] id: GO:0007594 name: puparial adhesion namespace: biological_process def: "The adhesion of the puparia of Diptera to their substrate; normally effected by a 'glue' secreted by the larval salivary gland and expectorated at the time of pupariation." [GOC:ma] synonym: "puparial glue" RELATED [] is_a: GO:0022609 ! multicellular organism adhesion to substrate relationship: part_of GO:0007591 ! molting cycle, chitin-based cuticle [Term] id: GO:0007595 name: lactation namespace: biological_process def: "The secretion of milk by the mammary gland." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Lactation is_a: GO:0007589 ! body fluid secretion is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0030879 ! mammary gland development [Term] id: GO:0007596 name: blood coagulation namespace: biological_process def: "The sequential process by which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers." [http://www.graylab.ac.uk/omd/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "blood clotting" EXACT [] xref: Reactome:109582 "Hemostasis" xref: Reactome:140875 "Common Pathway" xref: Reactome:140877 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:562589 "Hemostasis" xref: Reactome:562711 "Common Pathway" xref: Reactome:562712 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:588215 "Hemostasis" xref: Reactome:588332 "Common Pathway" xref: Reactome:588333 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:608976 "Hemostasis" xref: Reactome:609075 "Common Pathway" xref: Reactome:609076 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:633658 "Hemostasis" xref: Reactome:633769 "Common Pathway" xref: Reactome:633770 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:645405 "Hemostasis" xref: Reactome:645765 "Formation of Fibrin Clot (Clotting Cascade)" xref: Reactome:655773 "Hemostasis" xref: Reactome:660937 "Hemostasis" xref: Reactome:666712 "Hemostasis" xref: Reactome:672808 "Hemostasis" xref: Reactome:678532 "Hemostasis" xref: Reactome:683488 "Hemostasis" xref: Reactome:689691 "Hemostasis" xref: Reactome:701428 "Hemostasis" xref: Reactome:715999 "Hemostasis" xref: Reactome:720662 "Hemostasis" xref: Reactome:727947 "Hemostasis" xref: Reactome:731048 "Hemostasis" xref: Reactome:733105 "Hemostasis" xref: Reactome:735558 "Hemostasis" xref: Reactome:736595 "Hemostasis" xref: Reactome:738467 "Hemostasis" xref: Wikipedia:Coagulation is_a: GO:0007599 ! hemostasis is_a: GO:0050817 ! coagulation relationship: part_of GO:0042060 ! wound healing [Term] id: GO:0007597 name: blood coagulation, intrinsic pathway namespace: biological_process def: "A pathway of blood coagulation that occurs during the clotting of platelet-poor plasma, in which activation of factor X to factor Xa is effected by the combination of factor IXa + factor VIIIa + calcium ion + phospholipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process term 'blood coagulation, extrinsic pathway ; GO:0007598'. xref: Reactome:140837 "Intrinsic Pathway" xref: Reactome:563167 "Intrinsic Pathway" xref: Reactome:588777 "Intrinsic Pathway" xref: Reactome:609505 "Intrinsic Pathway" xref: Reactome:634211 "Intrinsic Pathway" xref: Reactome:645764 "Intrinsic Pathway" is_a: GO:0007596 ! blood coagulation [Term] id: GO:0007598 name: blood coagulation, extrinsic pathway namespace: biological_process def: "A pathway of blood coagulation in which the earlier stages of the cascade are bypassed and the activation of factor X to factor Xa is effected by the combination of factor VIIa + thromboplastin; this second pathway occurs when tissue extracts are present in optimal amounts and is much more rapid than the intrinsic pathway." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process term 'blood coagulation, intrinsic pathway ; GO:0007597'. xref: Reactome:140834 "Extrinsic Pathway" xref: Reactome:563168 "Extrinsic Pathway" xref: Reactome:588778 "Extrinsic Pathway" xref: Reactome:609506 "Extrinsic Pathway" xref: Reactome:634210 "Extrinsic Pathway" is_a: GO:0007596 ! blood coagulation [Term] id: GO:0007599 name: hemostasis namespace: biological_process def: "The stopping of bleeding (loss of body fluid) or the arrest of the circulation to an organ or part." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Hemostasis is_a: GO:0050878 ! regulation of body fluid levels [Term] id: GO:0007600 name: sensory perception namespace: biological_process def: "The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai, GOC:dph] xref: Wikipedia:Perception is_a: GO:0050890 ! cognition [Term] id: GO:0007601 name: visual perception namespace: biological_process def: "The series of events required for an organism to receive a visual stimulus, convert it to a molecular signal, and recognize and characterize the signal. Visual stimuli are detected in the form of photons and are processed to form an image." [GOC:ai] synonym: "sense of sight" EXACT [] synonym: "sensory visual perception" EXACT [] synonym: "vision" EXACT [] xref: Wikipedia:Visual_perception is_a: GO:0050953 ! sensory perception of light stimulus [Term] id: GO:0007602 name: phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons into a molecular signal." [GOC:go_curators] subset: gosubset_prok synonym: "opsin" RELATED [] synonym: "phototransduction, visible light, light adaptation" NARROW [] synonym: "phototrophin mediated phototransduction" NARROW [] xref: Wikipedia:Visual_phototransduction is_a: GO:0007165 ! signal transduction is_a: GO:0009583 ! detection of light stimulus is_a: GO:0051716 ! cellular response to stimulus [Term] id: GO:0007603 name: phototransduction, visible light namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from visible light into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0007602 ! phototransduction is_a: GO:0009584 ! detection of visible light [Term] id: GO:0007604 name: phototransduction, UV namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV light into a molecular signal; ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phototransduction, ultraviolet light" EXACT [] synonym: "phototransduction, ultraviolet radiation" EXACT [] synonym: "phototransduction, UV light" EXACT [] synonym: "phototransduction, UV radiation" EXACT [] synonym: "UV-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction is_a: GO:0009589 ! detection of UV is_a: GO:0034644 ! cellular response to UV [Term] id: GO:0007605 name: sensory perception of sound namespace: biological_process def: "The series of events required for an organism to receive an auditory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Sonic stimuli are detected in the form of vibrations and are processed to form a sound." [GOC:ai] synonym: "hearing" EXACT [] synonym: "perception of sound" EXACT [] xref: Wikipedia:Hearing_(sense) is_a: GO:0050954 ! sensory perception of mechanical stimulus [Term] id: GO:0007606 name: sensory perception of chemical stimulus namespace: biological_process def: "The series of events required for an organism to receive a sensory chemical stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process." [GOC:ai] synonym: "chemosensory perception" EXACT [] is_a: GO:0007600 ! sensory perception [Term] id: GO:0007607 name: taste perception namespace: biological_process def: "OBSOLETE. The series of events required for the chemical composition of a soluble stimulus to be received and converted to a molecular signal." [GOC:jl, ISBN:0395825172] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. is_obsolete: true consider: GO:0050909 consider: GO:0050912 [Term] id: GO:0007608 name: sensory perception of smell namespace: biological_process def: "The series of events required for an organism to receive an olfactory stimulus, convert it to a molecular signal, and recognize and characterize the signal. Olfaction involves the detection of chemical composition of an organism's ambient medium by chemoreceptors. This is a neurological process." [GOC:ai, http://www.onelook.com/] synonym: "olfaction" EXACT [] synonym: "scent perception" EXACT [] synonym: "sense of smell" EXACT [] synonym: "smell perception" EXACT [] xref: Wikipedia:Olfaction is_a: GO:0007606 ! sensory perception of chemical stimulus [Term] id: GO:0007610 name: behavior namespace: biological_process def: "The specific actions or reactions of an organism in response to external or internal stimuli. Patterned activity of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:ems, ISBN:0395448956] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "behavioral response to stimulus" EXACT [] synonym: "behaviour" EXACT [] synonym: "behavioural response to stimulus" EXACT [] xref: Wikipedia:Behavior is_a: GO:0050896 ! response to stimulus [Term] id: GO:0007611 name: learning or memory namespace: biological_process def: "The acquisition and processing of information and/or the storage and retrieval of this information over time." [GOC:jid, PMID:8938125] is_a: GO:0007610 ! behavior is_a: GO:0050890 ! cognition [Term] id: GO:0007612 name: learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs as the result of experience." [ISBN:0582227089, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Wikipedia:Learning is_a: GO:0007611 ! learning or memory [Term] id: GO:0007613 name: memory namespace: biological_process def: "The activities involved in the mental information processing system that receives (registers), modifies, stores, and retrieves informational stimuli. The main stages involved in the formation and retrieval of memory are encoding (processing of received information by acquisition), storage (building a permanent record of received information as a result of consolidation) and retrieval (calling back the stored information and use it in a suitable way to execute a given task)." [http://cancerweb.ncl.ac.uk/, http://www.onelook.com/, ISBN:0582227089] xref: Wikipedia:Memory is_a: GO:0007611 ! learning or memory [Term] id: GO:0007614 name: short-term memory namespace: biological_process def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information received a short time (up to about 30 minutes) ago. This type of memory is typically dependent on direct, transient effects of second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Short-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007615 name: anesthesia-resistant memory namespace: biological_process is_a: GO:0007613 ! memory [Term] id: GO:0007616 name: long-term memory namespace: biological_process def: "The activities involved in the mental information processing system that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation." [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] xref: Wikipedia:Long-term_memory is_a: GO:0007613 ! memory [Term] id: GO:0007617 name: mating behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of mating, or sexual reproduction resulting in the formation of zygotes." [GOC:ai, GOC:dph] synonym: "mating behaviour" EXACT [] xref: Wikipedia:Mating_behaviour is_a: GO:0019098 ! reproductive behavior is_a: GO:0051705 ! behavioral interaction between organisms relationship: part_of GO:0007618 ! mating [Term] id: GO:0007618 name: mating namespace: biological_process def: "The pairwise union of individuals for the purpose of sexual reproduction, ultimately resulting in the formation of zygotes." [ISBN:0387520546] is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0007619 name: courtship behavior namespace: biological_process def: "The behavioral interactions between organisms for the purpose of attracting sexual partners." [GOC:ai, GOC:dph] synonym: "courtship behaviour" EXACT [] is_a: GO:0007617 ! mating behavior is_a: GO:0023032 ! behavioral signaling [Term] id: GO:0007620 name: copulation namespace: biological_process def: "The act of sexual union between male and female, involving the transfer of sperm." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] is_a: GO:0007618 ! mating [Term] id: GO:0007621 name: negative regulation of female receptivity namespace: biological_process def: "Any process that stops, prevents or reduces the receptiveness of a female to male advances." [GOC:bf, PMID:11092827] synonym: "down regulation of female receptivity" EXACT [] synonym: "down-regulation of female receptivity" EXACT [] synonym: "downregulation of female receptivity" EXACT [] synonym: "inhibition of female receptivity" NARROW [] is_a: GO:0045924 ! regulation of female receptivity [Term] id: GO:0007622 name: rhythmic behavior namespace: biological_process def: "The specific actions or reactions of an organism that recur with measured regularity." [GOC:jl] synonym: "rhythmic behavioral response to stimulus" EXACT [] synonym: "rhythmic behaviour" EXACT [] synonym: "rhythmic behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007623 name: circadian rhythm namespace: biological_process alt_id: GO:0050895 def: "Any biological process in an organism that recurs with a regularity of approximately 24 hours." [GOC:bf, GOC:go_curators] subset: gosubset_prok synonym: "circadian process" EXACT [] synonym: "circadian response" RELATED [] synonym: "response to circadian rhythm" RELATED [] xref: Wikipedia:Circadian_rhythm is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007624 name: ultradian rhythm namespace: biological_process def: "The specific actions or reactions of an organism that recur with a regularity more frequent than every 24 hours." [GOC:jl, http://cancerweb.ncl.ac.uk/] is_a: GO:0048511 ! rhythmic process [Term] id: GO:0007625 name: grooming behavior namespace: biological_process def: "The specific actions or reactions of an organism relating to grooming, cleaning and brushing to remove dirt and parasites." [GOC:jl] synonym: "grooming behaviour" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007626 name: locomotory behavior namespace: biological_process def: "The specific movement from place to place of an organism in response to external or internal stimuli. Locomotion of a whole organism in a manner dependent upon some combination of that organism's internal state and external conditions." [GOC:dph] subset: gosubset_prok synonym: "behavior via locomotion" EXACT [] synonym: "locomotion in response to stimulus" EXACT [] synonym: "locomotory behavioral response to stimulus" EXACT [] synonym: "locomotory behaviour" EXACT [] synonym: "locomotory behavioural response to stimulus" EXACT [] is_a: GO:0007610 ! behavior [Term] id: GO:0007627 name: larval behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a larval form of an organism, an immature organism that must undergo metamorphosis to assume adult characteristics, as seen in insects." [GOC:ai, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0007628 name: adult walking behavior namespace: biological_process def: "The actions or reactions of an adult relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:jid, ISBN:0198606907] synonym: "adult walking behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007629 name: flight behavior namespace: biological_process def: "The response to external or internal stimuli that results in the locomotory process of flight. Flight is the self-propelled movement of an organism through the air." [GOC:jid, ISBN:0198606907] synonym: "flight behaviour" EXACT [] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007630 name: jump response namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to an external stimulus." [GOC:jid, ISBN:0198606907] is_a: GO:0008344 ! adult locomotory behavior [Term] id: GO:0007631 name: feeding behavior namespace: biological_process def: "Behavior associated with the intake of food." [GOC:mah] comment: See also the biological process term 'behavior ; GO:0007610'. synonym: "behavioral response to food" EXACT [] synonym: "behavioural response to food" EXACT [] synonym: "drinking" NARROW [] synonym: "eating" NARROW [] synonym: "feeding behaviour" EXACT [] xref: Wikipedia:List_of_feeding_behaviours is_a: GO:0007610 ! behavior [Term] id: GO:0007632 name: visual behavior namespace: biological_process def: "The actions or reactions of an organism in response to a visual stimulus." [GOC:jid] synonym: "behavioral response to visual stimulus" EXACT [] synonym: "behavioural response to visual stimulus" EXACT [] synonym: "visual behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009416 ! response to light stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0007633 name: pattern orientation namespace: biological_process def: "The actions or reactions of an individual in response to the orientation of a visual pattern. This is exemplified by some classes of insects which are able to detect and learn the orientation of a set of stripes and subsequently behaviorally discriminate between horizontal, vertical or 45 degree stripes." [GOC:jid, PMID:9933535] synonym: "behavioral response to pattern orientation" EXACT [] synonym: "behavioural response to pattern orientation" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007634 name: optokinetic behavior namespace: biological_process def: "The actions or reactions of an organism pertaining to movement of the eyes and of objects in the visual field, as in nystagmus." [GOC:jid, http://www.mercksource.com] synonym: "optokinetic behaviour" EXACT [] is_a: GO:0007632 ! visual behavior [Term] id: GO:0007635 name: chemosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of chemicals." [GOC:go_curators] synonym: "behavioral response to chemical stimulus" EXACT [] synonym: "behavioural response to chemical stimulus" EXACT [] synonym: "chemosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0007636 name: chemosensory jump behavior namespace: biological_process def: "The sudden, usually upward, movement off the ground or other surface through sudden muscular effort in the legs, following exposure to a chemical substance." [GOC:jid] synonym: "chemosensory jump behaviour" EXACT [] synonym: "jump response to chemical stimulus" EXACT [] is_a: GO:0007630 ! jump response is_a: GO:0007635 ! chemosensory behavior [Term] id: GO:0007637 name: proboscis extension reflex namespace: biological_process def: "The extension, through direct muscle actions, of the proboscis (the trunk-like extension of the mouthparts on the adult external head) in response to a sugar stimulus." [FB:FBrf0044924, GOC:jid, http://fbserver.gen.cam.ac.uk] synonym: "behavioral response to sugar stimulus, proboscis extension" EXACT [] synonym: "proboscis extension in response to sugar stimulus" EXACT [] is_a: GO:0007635 ! chemosensory behavior is_a: GO:0051780 ! behavioral response to nutrient is_a: GO:0060004 ! reflex [Term] id: GO:0007638 name: mechanosensory behavior namespace: biological_process def: "Behavior that is dependent upon the sensation of a mechanical stimulus." [GOC:go_curators] synonym: "behavioral response to mechanical stimulus" EXACT [] synonym: "behavioural response to mechanical stimulus" EXACT [] synonym: "mechanosensory behaviour" EXACT [] is_a: GO:0007610 ! behavior is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0007639 name: homeostasis of number of meristem cells namespace: biological_process def: "Any biological process involved in the maintenance of the steady-state of cell number within a population of cells in the meristem." [GOC:isa_complete] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048873 ! homeostasis of number of cells within a tissue [Term] id: GO:0008001 name: fibrinogen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it does not describe an activity. is_obsolete: true replaced_by: GO:0005577 [Term] id: GO:0008002 name: lamina lucida namespace: cellular_component def: "The electron-lucent layer of the basal lamina adjacent to the basal plasma membrane of the cells that rest on the lamina." [ISBN:0815316194] xref: Wikipedia:Lamina_lucida is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008003 name: lamina densa namespace: cellular_component def: "The electron-dense layer of the basal lamina; lies just below the lamina lucida." [ISBN:0815316194] xref: Wikipedia:Lamina_densa is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008004 name: lamina reticularis namespace: cellular_component def: "A layer of the basal lamina that contains collagen fibrils and connects the basal lamina to the underlying connective tissue." [ISBN:0815316194] is_a: GO:0044420 ! extracellular matrix part relationship: part_of GO:0005605 ! basal lamina [Term] id: GO:0008008 name: membrane attack complex protein beta2 chain namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0005579 [Term] id: GO:0008009 name: chemokine activity namespace: molecular_function def: "The function of a family of chemotactic pro-inflammatory activation-inducible cytokines acting primarily upon hemopoietic cells in immunoregulatory processes; all chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation." [http://www.copewithcytokines.de/cope.cgi?key=Cytokines] comment: See also the molecular function term 'cytokine activity ; GO:0005125'. is_a: GO:0005125 ! cytokine activity is_a: GO:0042379 ! chemokine receptor binding [Term] id: GO:0008010 name: structural constituent of chitin-based larval cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a larva. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of larval cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008011 name: structural constituent of pupal chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of a pupa. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of pupal cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008012 name: structural constituent of adult chitin-based cuticle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the chitin-based cuticle of an adult organism. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:mtg_sensu] synonym: "structural constituent of adult cuticle" BROAD [] is_a: GO:0005214 ! structural constituent of chitin-based cuticle [Term] id: GO:0008013 name: beta-catenin binding namespace: molecular_function def: "Interacting selectively and non-covalently with the beta subunit of the catenin complex." [GOC:bf] is_a: GO:0005515 ! protein binding [Term] id: GO:0008014 name: calcium-dependent cell adhesion molecule activity namespace: molecular_function alt_id: GO:0001538 def: "OBSOLETE. A calcium-dependent cell adhesion protein (type I membrane protein) that interacts in a homophilic manner in cell-cell interactions." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product. synonym: "cadherin" NARROW [] is_obsolete: true replaced_by: GO:0005515 replaced_by: GO:0016021 replaced_by: GO:0016339 [Term] id: GO:0008015 name: blood circulation namespace: biological_process alt_id: GO:0070261 def: "The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products." [GOC:mtg_heart, ISBN:0192800825] subset: goslim_pir synonym: "hemolymph circulation" RELATED [] is_a: GO:0003013 ! circulatory system process [Term] id: GO:0008016 name: regulation of heart contraction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of heart contraction. Heart contraction is the process by which the heart decreases in volume in a characteristic way to propel blood through the body." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of cardiac contraction" EXACT [] is_a: GO:0044057 ! regulation of system process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060047 ! heart contraction relationship: regulates GO:0060047 ! heart contraction [Term] id: GO:0008017 name: microtubule binding namespace: molecular_function def: "Interacting selectively and non-covalently with microtubules, filaments composed of tubulin monomers." [GOC:krc] synonym: "microtubule severing activity" RELATED [] synonym: "microtubule/chromatin interaction" RELATED [] is_a: GO:0015631 ! tubulin binding [Term] id: GO:0008018 name: structural protein of chorion (sensu Drosophila) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the function is covered by a parent term. is_obsolete: true replaced_by: GO:0005213 [Term] id: GO:0008019 name: macrophage receptor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because its name is ambiguous, and it was never defined. is_obsolete: true consider: GO:0005044 consider: GO:0008329 [Term] id: GO:0008020 name: G-protein coupled photoreceptor activity namespace: molecular_function alt_id: GO:0004975 def: "A G-protein coupled receptor that responds to incidental electromagnetic radiation, particularly visible light." [GOC:dph, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "G protein coupled photoreceptor activity" EXACT [] synonym: "G-protein-coupled photoreceptor activity" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009584 ! detection of visible light [Term] id: GO:0008021 name: synaptic vesicle namespace: cellular_component def: "A secretory organelle, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and is secreted these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane." [PMID:10099709] xref: NIF_Subcellular:sao1071221672 xref: Wikipedia:Synaptic_vesicle is_a: GO:0030136 ! clathrin-coated vesicle is_a: GO:0044456 ! synapse part intersection_of: GO:0031982 ! vesicle intersection_of: part_of GO:0045202 ! synapse [Term] id: GO:0008022 name: protein C-terminus binding namespace: molecular_function def: "Interacting selectively and non-covalently with a protein C-terminus, the end of any peptide chain at which the 1-carboxy function of a constituent amino acid is not attached in peptide linkage to another amino-acid residue." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "C-terminal binding" EXACT [] synonym: "C-terminal end binding" EXACT [GOC:sl] synonym: "carboxy-terminal binding" RELATED [GOC:jsg] synonym: "carboxy-terminus binding" RELATED [GOC:sl] synonym: "carboxyl-terminal binding" RELATED [GOC:jsg] synonym: "carboxyl-terminus binding" RELATED [GOC:sl] synonym: "carboxylate-terminal binding" RELATED [GOC:jsg] synonym: "carboxylate-terminus binding" NARROW [GOC:jsg] synonym: "COOH-terminal binding" NARROW [GOC:jsg] synonym: "COOH-terminus binding" NARROW [GOC:jsg, GOC:sl] is_a: GO:0005515 ! protein binding [Term] id: GO:0008023 name: transcription elongation factor complex namespace: cellular_component def: "Any protein complex that interacts with RNA polymerase II to increase (positive transcription elongation factor) or reduce (negative transcription elongation factor) the rate of transcription elongation." [GOC:jl] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044451 ! nucleoplasm part [Term] id: GO:0008024 name: positive transcription elongation factor complex b namespace: cellular_component def: "A transcription elongation factor complex that facilitates the transition from abortive to productive elongation by phosphorylating the CTD domain of the large subunit of DNA-directed RNA polymerase II, holoenzyme. Contains cyclin T and a cyclin-dependent protein kinase catalytic subunit." [PMID:10766736, PMID:16721054, PMID:17079683, PMID:19328067, PMID:7759473] comment: See also the cellular component terms 'cyclin-dependent protein kinase activating kinase holoenzyme complex ; GO:0019907' and 'DNA-directed RNA polymerase II, holoenzyme ; GO:0016591'. synonym: "P-TEFb" EXACT [PMID:7759473] is_a: GO:0008023 ! transcription elongation factor complex is_a: GO:0032806 ! carboxy-terminal domain protein kinase complex [Term] id: GO:0008025 name: diazepam binding inhibitor activity namespace: molecular_function def: "OBSOLETE. The diazepam binding inhibitor is a 10kDa 86-residue polypeptide that acts as an endogenous ligand for a mitochondrial receptor (formerly regarded as a peripheral benzodiazepine binding site) in steroidogenic cells and regulates stimulation of steroidogenesis by tropic hormones. It also binds to the GABA-A receptor and modulates glucose-dependent insulin secretion and synthesis of acyl-CoA esters." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11883709] comment: This term was made obsolete because it represents a multifunctional gene product. synonym: "DBI" EXACT [] synonym: "diazepam-binding inhibitor activity" EXACT [] is_obsolete: true consider: GO:0004857 consider: GO:0030156 consider: GO:0050796 consider: GO:0050809 consider: GO:0050810 consider: GO:0050811 consider: GO:0050812 [Term] id: GO:0008026 name: ATP-dependent helicase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate to drive the unwinding of a DNA or RNA helix." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok is_a: GO:0042623 ! ATPase activity, coupled is_a: GO:0070035 ! purine NTP-dependent helicase activity [Term] id: GO:0008028 name: monocarboxylic acid transmembrane transporter activity namespace: molecular_function alt_id: GO:0008505 def: "Catalysis of the transfer of monocarboxylic acids from one side of the membrane to the other. A monocarboxylic acid is an organic acid with one COOH group." [GOC:ai] subset: gosubset_prok synonym: "monocarboxylate carrier" NARROW [] synonym: "prostaglandin/thromboxane transporter activity" NARROW [] xref: Reactome:14156 "monocarboxylic acid transmembrane transporter activity" is_a: GO:0046943 ! carboxylic acid transmembrane transporter activity relationship: part_of GO:0015718 ! monocarboxylic acid transport [Term] id: GO:0008029 name: pentraxin receptor activity namespace: molecular_function def: "Combining with a pentraxin to initiate a change in cell activity." [GOC:add, ISBN:0781735149 "Fundamental Immunology"] comment: Note that pentraxins include such proteins as serum amyloid P component (SAP) and C-reactive protein (CRP). synonym: "pentaxin receptor" EXACT [] is_a: GO:0001847 ! opsonin receptor activity is_a: GO:0001864 ! pentraxin binding [Term] id: GO:0008030 name: neuronal pentraxin receptor activity namespace: molecular_function synonym: "neuronal pentaxin receptor" EXACT [] is_a: GO:0008029 ! pentraxin receptor activity [Term] id: GO:0008031 name: eclosion hormone activity namespace: molecular_function def: "The action characteristic of eclosion hormone, a peptide hormone that, upon receptor binding, triggers the death of certain muscles and neurons during insect metamorphosis." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008033 name: tRNA processing namespace: biological_process def: "The process by which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group." [GOC:jl, PMID:12533506] subset: gosubset_prok synonym: "tRNA maturation" EXACT [GOC:vw] is_a: GO:0006399 ! tRNA metabolic process is_a: GO:0034470 ! ncRNA processing [Term] id: GO:0008034 name: lipoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any conjugated, water-soluble protein in which the nonprotein moiety consists of a lipid or lipids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0008035 name: high-density lipoprotein binding namespace: molecular_function def: "Interacting selectively and non-covalently with high-density lipoprotein: one of the classes of lipoproteins found in blood plasma in many animals (data normally relate to humans)." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0008034 ! lipoprotein binding [Term] id: GO:0008036 name: diuretic hormone receptor activity namespace: molecular_function def: "Combining with a diuretic hormone to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity relationship: part_of GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0008037 name: cell recognition namespace: biological_process def: "The process by which a cell in a multicellular organism interprets its surroundings." [GOC:go_curators] subset: goslim_generic subset: goslim_pir is_a: GO:0009987 ! cellular process relationship: part_of GO:0032501 ! multicellular organismal process [Term] id: GO:0008038 name: neuron recognition namespace: biological_process def: "The process by which a neuronal cell in a multicellular organism interprets its surroundings." [GOC:go_curators] synonym: "neuronal cell recognition" EXACT [] is_a: GO:0008037 ! cell recognition relationship: part_of GO:0048666 ! neuron development [Term] id: GO:0008039 name: synaptic target recognition namespace: biological_process def: "The process by which a neuronal cell in a multicellular organism interprets signals produced by potential target cells, with which it may form synapses." [GOC:mah, ISBN:0878932437] synonym: "neuronal targeting" EXACT [] is_a: GO:0008038 ! neuron recognition [Term] id: GO:0008041 name: storage protein of fat body (sensu Insecta) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it describes a cellular location rather than a function. is_obsolete: true replaced_by: GO:0045735 [Term] id: GO:0008042 name: iron-sulfur electron transfer carrier namespace: molecular_function def: "OBSOLETE. An iron-sulfur protein that serves as an electron acceptor and electron donor in an electron transport system." [GOC:kd] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ferredoxin" NARROW [] synonym: "iron-sulphur electron transfer carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008043 name: intracellular ferritin complex namespace: cellular_component def: "A ferritin complex located in the cell. Intracellular ferritin complexes contain 24 subunits, in a mixture of L (light) chains and H (heavy) chains." [GOC:jl, GOC:mah, PMID:19154717] is_a: GO:0044424 ! intracellular part is_a: GO:0070288 ! ferritin complex [Term] id: GO:0008044 name: adult behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Behavior in a fully developed and mature organism, as seen in insects." [GOC:bf, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true replaced_by: GO:0030534 [Term] id: GO:0008045 name: motor axon guidance namespace: biological_process def: "The process by which the migration of an axon growth cone of a motor neuron is directed to a specific target site in response to a combination of attractive and repulsive cues." [ISBN:0878932437] synonym: "motor axon pathfinding" EXACT [GOC:mah] is_a: GO:0007411 ! axon guidance [Term] id: GO:0008046 name: axon guidance receptor activity namespace: molecular_function def: "Combining with an extracellular messenger that results in a change in cellular activity involved in axon guidance." [GOC:dph, GOC:tb] is_a: GO:0004888 ! transmembrane receptor activity relationship: part_of GO:0007411 ! axon guidance [Term] id: GO:0008047 name: enzyme activator activity namespace: molecular_function def: "Increases the activity of an enzyme." [GOC:mah] subset: gosubset_prok is_a: GO:0030234 ! enzyme regulator activity [Term] id: GO:0008048 name: calcium sensitive guanylate cyclase activator activity namespace: molecular_function is_a: GO:0030250 ! guanylate cyclase activator activity [Term] id: GO:0008049 name: male courtship behavior namespace: biological_process alt_id: GO:0016542 def: "The actions or reactions of a male, for the purpose of attracting a sexual partner. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu] synonym: "male courtship behaviour" EXACT [] is_a: GO:0060179 ! male mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008050 name: female courtship behavior namespace: biological_process def: "The actions or reactions of a female, for the purpose of attracting a sexual partner." [GOC:bf] synonym: "female courtship behaviour" EXACT [] is_a: GO:0060180 ! female mating behavior relationship: part_of GO:0007619 ! courtship behavior [Term] id: GO:0008051 name: farnesyl-diphosphate farnesyl transferase complex namespace: cellular_component def: "OBSOLETE. A complex that possesses farnesyl-diphosphate farnesyl transferase activity." [GOC:mah] comment: This term was made obsolete because there is no evidence that this enzyme ever exists as anything other than a monomer. is_obsolete: true consider: GO:0004310 [Term] id: GO:0008052 name: sensory organ boundary specification namespace: biological_process def: "The process by which boundaries between a sensory organ and the surrounding tissue are established and maintained." [GO_REF:0000021, GOC:mtg_15jun06] comment: This term was added by GO_REF:0000021. synonym: "sense organ boundary specification" EXACT [GOC:dph] is_a: GO:0010160 ! formation of organ boundary relationship: part_of GO:0007423 ! sensory organ development [Term] id: GO:0008053 name: mitochondrial fusion namespace: biological_process def: "Merging of two or more mitochondria within a cell to form a single compartment." [PMID:11038192] is_a: GO:0006944 ! cellular membrane fusion is_a: GO:0048284 ! organelle fusion is_a: GO:0070584 ! mitochondrion morphogenesis [Term] id: GO:0008054 name: cyclin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclins, proteins whose levels in a cell varies markedly during the cell cycle, and which play key roles in regulating cell cycle phase transitions." [GOC:mah, http://cancerweb.ncl.ac.uk/] synonym: "cyclin breakdown" EXACT [] synonym: "cyclin catabolism" EXACT [] synonym: "cyclin degradation" EXACT [] synonym: "degradation of cyclin" EXACT [] is_a: GO:0043161 ! proteasomal ubiquitin-dependent protein catabolic process [Term] id: GO:0008055 name: ocellus pigment biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ocellus pigments, any general or particular coloring matter in living organisms, found or utilized in the ocellus, a minute simple eye found in many invertebrates." [GOC:ai, http://cancerweb.ncl.ac.uk/] synonym: "ocellus pigment anabolism" EXACT [] synonym: "ocellus pigment biosynthesis" EXACT [] synonym: "ocellus pigment formation" EXACT [] synonym: "ocellus pigment synthesis" EXACT [] is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046158 ! ocellus pigment metabolic process [Term] id: GO:0008056 name: ocellus development namespace: biological_process def: "The process whose specific outcome is the progression of the ocellus over time, from its formation to the mature structure. The ocellus is a simple visual organ of insects." [http://fly.ebi.ac.uk/.bin/cvreport2?id=FBcv0004540] is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0035214 ! eye-antennal disc development [Term] id: GO:0008057 name: eye pigment granule organization namespace: biological_process alt_id: GO:0008059 alt_id: GO:0045318 alt_id: GO:0048751 def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the eye." [PMID:9303295] synonym: "eye pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008058 name: ocellus pigment granule organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of intracellular pigment storage granules in the ocellus." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm] synonym: "ocellus pigment granule organisation" EXACT [GOC:curators] synonym: "ocellus pigment granule organization and biogenesis" RELATED [GOC:mah] is_a: GO:0048753 ! pigment granule organization [Term] id: GO:0008060 name: ARF GTPase activator activity namespace: molecular_function def: "Increases the rate of GTP hydrolysis by the GTPase ARF." [GOC:mah] synonym: "ARF GAP activity" EXACT [GOC:pg] is_a: GO:0005083 ! small GTPase regulator activity is_a: GO:0005096 ! GTPase activator activity [Term] id: GO:0008061 name: chitin binding namespace: molecular_function def: "Interacting selectively and non-covalently with chitin, a linear polysaccharide consisting of P-1,4-linked N-acetyl-D-glucosamine residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0008062 name: eclosion rhythm namespace: biological_process def: "The timing of the emergence of the adult fly from its pupal case, which usually occurs at dawn." [PMID:11715043] is_a: GO:0048512 ! circadian behavior relationship: part_of GO:0007562 ! eclosion [Term] id: GO:0008063 name: Toll signaling pathway namespace: biological_process def: "The series of molecular signals initiated by binding of an extracellular ligand to the Toll receptor on the surface of the target cell." [GOC:go_curators, PMID:11135568, PMID:19126860] synonym: "Tl signaling pathway" EXACT [] synonym: "Tl signalling pathway" EXACT [] synonym: "Toll signalling pathway" EXACT [] xref: Reactome:166016 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:562915 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:588536 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:609739 "Toll Like Receptor 4 (TLR4) Cascade" xref: Reactome:634286 "Toll Like Receptor 4 (TLR4) Cascade" is_a: GO:0007166 ! cell surface receptor linked signaling pathway [Term] id: GO:0008064 name: regulation of actin polymerization or depolymerization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0030832 ! regulation of actin filament length intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008154 ! actin polymerization or depolymerization relationship: regulates GO:0008154 ! actin polymerization or depolymerization [Term] id: GO:0008065 name: establishment of blood-nerve barrier namespace: biological_process def: "The establishment of the barrier between the perineurium of peripheral nerves and the vascular endothelium of endoneurial capillaries. The perineurium acts as a diffusion barrier, but ion permeability at the blood-nerve barrier is still higher than at the blood-brain barrier." [GOC:dgh] synonym: "establishment of blood/nerve barrier" EXACT [] is_a: GO:0001885 ! endothelial cell development relationship: part_of GO:0007422 ! peripheral nervous system development [Term] id: GO:0008066 name: glutamate receptor activity namespace: molecular_function def: "Combining with glutamate to initiate a change in cell activity." [GOC:ai] subset: gosubset_prok is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008067 name: metabotropic glutamate, GABA-B-like receptor activity namespace: molecular_function alt_id: GO:0001643 alt_id: GO:0001645 def: "OBSOLETE. A G-protein coupled receptor that is structurally/functionally related to the metabotropic glutamate receptor." [GOC:dph, GOC:mah, GOC:tb, IUPHAR_GPCR:1285] comment: This term was made obsolete because it represents a gene product and is named based on protein features. synonym: "class C G protein coupled receptor" BROAD [] synonym: "class C G-protein coupled receptor" BROAD [] synonym: "class C GPCR" BROAD [] synonym: "class C orphan receptor activity" EXACT [] is_obsolete: true [Term] id: GO:0008068 name: extracellular-glutamate-gated chloride channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a chloride ion by a channel that opens when extracellular glutamate has been bound by the channel complex or one of its constituent parts." [GOC:mtg_transport, ISBN:0815340729] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'glutamate receptor activity ; GO:0008066'. is_a: GO:0005234 ! extracellular-glutamate-gated ion channel activity is_a: GO:0005254 ! chloride channel activity [Term] id: GO:0008069 name: dorsal/ventral axis specification, ovarian follicular epithelium namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal/ventral axis. An example of this process is found in Drosophila melanogaster." [GOC:bf, GOC:dph, GOC:mtg_sensu, GOC:tb] synonym: "dorsal-ventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination, follicular epithelium" RELATED [] synonym: "dorsal/ventral axis determination, ovarian follicular epithelium" EXACT [GOC:dph, GOC:tb] synonym: "dorsoventral axis specification, ovarian follicular epithelium" EXACT [GOC:mah] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009950 ! dorsal/ventral axis specification is_a: GO:0016334 ! establishment or maintenance of polarity of follicular epithelium is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0030707 ! ovarian follicle cell development [Term] id: GO:0008070 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, germ-line encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by cells of the germ line." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, germ-line encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008071 name: maternal determination of dorsal/ventral axis, ovarian follicular epithelium, soma encoded namespace: biological_process def: "Polarization of the ovarian follicle cells along the dorsal-ventral axis by a gene product encoded by somatic cells. An example of this process is found in Drosophila melanogaster." [GOC:mtg_sensu, ISBN:0879694238] synonym: "maternal determination of dorsal-ventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] synonym: "maternal determination of dorsal/ventral axis, follicular epithelium, soma encoded" BROAD [] synonym: "maternal determination of dorsoventral axis, ovarian follicular epithelium, soma encoded" EXACT [GOC:mah] is_a: GO:0008069 ! dorsal/ventral axis specification, ovarian follicular epithelium [Term] id: GO:0008073 name: ornithine decarboxylase inhibitor activity namespace: molecular_function def: "The stopping, prevention or reduction of the activity of the enzyme ornithine decarboxylase." [GOC:jl] is_a: GO:0004857 ! enzyme inhibitor activity is_a: GO:0042979 ! ornithine decarboxylase regulator activity relationship: negatively_regulates GO:0004586 ! ornithine decarboxylase activity [Term] id: GO:0008074 name: guanylate cyclase complex, soluble namespace: cellular_component def: "Complex that possesses guanylate cyclase activity and is not bound to a membrane." [GOC:mah] comment: See also the molecular function term 'guanylate cyclase activity ; GO:0004383'. is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008075 name: receptor guanylate cyclase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP = 3',5'-cyclic GMP + diphosphate." [EC:4.6.1.2] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0004383 consider: GO:0004872 [Term] id: GO:0008076 name: voltage-gated potassium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which potassium ions may cross a cell membrane in response to changes in membrane potential." [GOC:mah] subset: gosubset_prok synonym: "voltage gated potassium channel complex" EXACT [] synonym: "voltage-dependent potassium channel complex" EXACT [] synonym: "voltage-sensitive potassium channel complex" EXACT [] xref: NIF_Subcellular:sao371494298 is_a: GO:0034705 ! potassium channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008077 name: Hsp70/Hsp90 organizing protein activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:rb] comment: This term was made obsolete because it represents a specific gene product rather than a molecular function. synonym: "Hsp70/Hsp90 organising protein activity" EXACT [] is_obsolete: true consider: GO:0030674 [Term] id: GO:0008078 name: mesodermal cell migration namespace: biological_process def: "The orderly movement of mesodermal cells from one site to another." [GOC:ascb_2009, GOC:dph, GOC:mah, GOC:tb] synonym: "mesoderm cell migration" EXACT [] is_a: GO:0042074 ! cell migration involved in gastrulation relationship: part_of GO:0007509 ! mesoderm migration [Term] id: GO:0008079 name: translation termination factor activity namespace: molecular_function def: "Functions in the termination of translation." [GOC:ma] subset: gosubset_prok is_a: GO:0008135 ! translation factor activity, nucleic acid binding relationship: part_of GO:0006415 ! translational termination relationship: part_of GO:0045905 ! positive regulation of translational termination [Term] id: GO:0008080 name: N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- is_a: GO:0016407 ! acetyltransferase activity is_a: GO:0016410 ! N-acyltransferase activity [Term] id: GO:0008081 name: phosphoric diester hydrolase activity namespace: molecular_function alt_id: GO:0016792 def: "Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "endonuclease VIII activity" RELATED [] synonym: "phosphodiesterase" NARROW [] xref: EC:3.1.4 is_a: GO:0042578 ! phosphoric ester hydrolase activity [Term] id: GO:0008083 name: growth factor activity namespace: molecular_function def: "The function that stimulates a cell to grow or proliferate. Most growth factors have other actions besides the induction of cell growth or proliferation." [ISBN:0815316194] is_a: GO:0005102 ! receptor binding [Term] id: GO:0008084 name: imaginal disc growth factor activity namespace: molecular_function is_a: GO:0070851 ! growth factor receptor binding [Term] id: GO:0008085 name: phototransduction, visible light, light adaptation namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because the term name is ambiguous. is_obsolete: true consider: GO:0007602 [Term] id: GO:0008086 name: light-activated voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a voltage-gated channel that is activated in response to light." [GOC:mtg_transport] synonym: "light-activated voltage gated calcium channel activity" EXACT [] synonym: "light-activated voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity is_a: GO:0010461 ! light-activated ion channel activity relationship: part_of GO:0019722 ! calcium-mediated signaling [Term] id: GO:0008087 name: light-activated voltage-gated calcium channel complex namespace: cellular_component def: "A protein complex that forms a transmembrane channel through which calcium ions may cross a cell membrane in response to changes in membrane potential generated in response to a light stimulus." [GOC:mah, PMID:9223679] synonym: "light-activated voltage gated calcium channel complex" EXACT [] synonym: "light-activated voltage-dependent calcium channel complex" EXACT [] synonym: "light-activated voltage-sensitive calcium channel complex" EXACT [] is_a: GO:0005891 ! voltage-gated calcium channel complex [Term] id: GO:0008088 name: axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules in nerve cell axons." [ISBN:0815316194] synonym: "axonal transport" EXACT [] xref: Wikipedia:Axoplasmic_transport is_a: GO:0010970 ! microtubule-based transport [Term] id: GO:0008089 name: anterograde axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell body toward the cell periphery in nerve cell axons." [ISBN:0815316194] synonym: "anterograde axonal transport" EXACT [] is_a: GO:0008088 ! axon cargo transport [Term] id: GO:0008090 name: retrograde axon cargo transport namespace: biological_process def: "The directed movement of organelles or molecules along microtubules from the cell periphery toward the cell body in nerve cell axons." [ISBN:0815316194] synonym: "retrograde axonal transport" RELATED [] is_a: GO:0008088 ! axon cargo transport [Term] id: GO:0008091 name: spectrin namespace: cellular_component def: "Membrane associated dimeric protein (240 and 220 kDa) of erythrocytes. Forms a complex with ankyrin, actin and probably other components of the membrane cytoskeleton, so that there is a mesh of proteins underlying the plasma membrane, potentially restricting the lateral mobility of integral proteins." [http://cancerweb.ncl.ac.uk/] xref: NIF_Subcellular:sao536287099 xref: Wikipedia:Spectrin is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044448 ! cell cortex part relationship: part_of GO:0030864 ! cortical actin cytoskeleton [Term] id: GO:0008092 name: cytoskeletal protein binding namespace: molecular_function def: "Interacting selectively and non-covalently with any protein component of any cytoskeleton (actin, microtubule, or intermediate filament cytoskeleton)." [GOC:mah] subset: goslim_generic subset: gosubset_prok is_a: GO:0005515 ! protein binding [Term] id: GO:0008093 name: cytoskeletal adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a cytoskeletal molecule and one or more other molecules, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0008092 ! cytoskeletal protein binding is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0008094 name: DNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004011 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate in the presence of single- or double-stranded DNA; drives another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "adenosinetriphosphatase (DNA-dependent)" EXACT [] synonym: "DNA dependent ATPase activity" EXACT [] synonym: "DNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008095 name: inositol-1,4,5-trisphosphate receptor activity namespace: molecular_function def: "Combining with inositol-1,4,5-trisphosphate to initiate a change in cell activity." [GOC:ai] synonym: "IP3 receptor activity" EXACT [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008096 name: juvenile hormone epoxide hydrolase activity namespace: molecular_function xref: EC:3.3.2.- is_a: GO:0004301 ! epoxide hydrolase activity [Term] id: GO:0008097 name: 5S rRNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 5S ribosomal RNA, the smallest RNA constituent of a ribosome." [GOC:jl, ISBN:0321000382] subset: gosubset_prok is_a: GO:0019843 ! rRNA binding [Term] id: GO:0008098 name: 5S rRNA primary transcript binding namespace: molecular_function def: "Interacting selectively and non-covalently with the unprocessed 5S ribosomal RNA transcript." [GOC:jl] is_a: GO:0008097 ! 5S rRNA binding [Term] id: GO:0008100 name: lipophorin namespace: molecular_function def: "OBSOLETE. Any member of the major class of lipid-transporting proteins found in the hemolymph of insects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0005319 [Term] id: GO:0008101 name: decapentaplegic receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a decapentaplegic receptor binding to one of its physiological ligands." [GOC:ai] synonym: "decapentaplegic receptor signalling pathway" EXACT [] synonym: "dpp receptor signaling pathway" EXACT [] synonym: "dpp receptor signalling pathway" EXACT [] is_a: GO:0007178 ! transmembrane receptor protein serine/threonine kinase signaling pathway [Term] id: GO:0008103 name: oocyte microtubule cytoskeleton polarization namespace: biological_process alt_id: GO:0048129 def: "Establishment and maintenance of a specific axis of polarity of the oocyte microtubule network. The axis is set so that the minus and plus ends of the microtubules of the mid stage oocyte are positioned along the anterior cortex and at the posterior pole, respectively. An example of this is found in Drosophila melanogaster." [GOC:mtg_sensu, PMID:11807042] is_a: GO:0007017 ! microtubule-based process is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007309 ! oocyte axis specification relationship: part_of GO:0016325 ! oocyte microtubule cytoskeleton organization [Term] id: GO:0008104 name: protein localization namespace: biological_process def: "Any process by which a protein is transported to, or maintained in, a specific location." [GOC:ai] subset: gosubset_prok synonym: "establishment and maintenance of protein localization" EXACT [] is_a: GO:0033036 ! macromolecule localization [Term] id: GO:0008105 name: asymmetric protein localization namespace: biological_process def: "Any process by which a protein is transported to, or maintained in, a specific asymmetric distribution." [GOC:ma] subset: gosubset_prok synonym: "establishment and maintenance of asymmetric protein localization" EXACT [] is_a: GO:0008104 ! protein localization [Term] id: GO:0008106 name: alcohol dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: an alcohol + NADP+ = an aldehyde + NADPH + H+." [EC:1.1.1.2] subset: gosubset_prok synonym: "aldehyde reductase (NADPH) activity" EXACT [EC:1.1.1.2] synonym: "aldehyde reductase (NADPH2)" EXACT [] synonym: "NADP-aldehyde reductase activity" EXACT [] xref: EC:1.1.1.2 xref: MetaCyc:ALCOHOL-DEHYDROGENASE-NADP+-RXN is_a: GO:0004033 ! aldo-keto reductase activity [Term] id: GO:0008107 name: galactoside 2-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + beta-D-galactosyl-R = GDP + alpha-L-fucosyl-(1,2)-beta-D-galactosyl-R." [EC:2.4.1.69] subset: gosubset_prok synonym: "alpha(1,2)-L-fucosyltransferase activity" EXACT [] synonym: "alpha-(1->2)-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha-1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "blood group H alpha-2-fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "blood-group substance H-dependent fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-beta-L-fucose:beta-D-galactosyl-R 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "GDP-L-fucose:lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphospho-L-fucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-beta-D-galactosyl-alpha-2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactoside 2-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosyl-glucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-galactosylacetylglucosaminylgalactosylglucosylceramide alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-glycoprotein 2-alpha-L-fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "guanosine diphosphofucose-lactose fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "H-gene-encoded beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha-1->2 fucosyltransferase activity" NARROW [EC:2.4.1.69] synonym: "secretor-type beta-galactoside alpha1->2 fucosyltransferase activity" EXACT [EC:2.4.1.69] xref: EC:2.4.1.69 xref: MetaCyc:GALACTOSIDE-2-L-FUCOSYLTRANSFERASE-RXN is_a: GO:0031127 ! alpha(1,2)-fucosyltransferase activity [Term] id: GO:0008108 name: UDP-glucose:hexose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + alpha-D-galactose 1-phosphate = alpha-D-glucose 1-phosphate + UDP-galactose." [EC:2.7.7.12] subset: gosubset_prok synonym: "Gal-1-P uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "galactose-1-phosphate uridylyltransferase activity" BROAD [EC:2.7.7.12] synonym: "hexose 1-phosphate uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDP-glucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose-hexose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "UDPglucose:alpha-D-galactose-1-phosphate uridylyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridyl transferase activity" BROAD [EC:2.7.7.12] synonym: "uridyltransferase activity" EXACT [EC:2.7.7.12] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.12] xref: EC:2.7.7.12 xref: MetaCyc:GALACTURIDYLYLTRANS-RXN xref: Reactome:22869 "UDP-glucose:hexose-1-phosphate uridylyltransferase activity" is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008109 name: N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,6-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.150] synonym: "galbeta1->4GlcNAc-R beta1->6 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "N-acetyllactosaminide beta-1,6-N-acetylglucosaminyl-transferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-GlcNAc:Gal-R, beta-D-6-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminide beta-1,6-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.150] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->6-acetylglucosaminyltransferase" BROAD [EC:2.4.1.150] xref: EC:2.4.1.150 xref: MetaCyc:2.4.1.150-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008110 name: L-histidine:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-histidine + 2-oxoglutarate = imidazol-5-yl-pyruvate + L-glutamate." [EC:2.6.1.38] synonym: "histidine aminotransferase activity" BROAD [] synonym: "histidine transaminase activity" BROAD [EC:2.6.1.38] synonym: "histidine-2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.38] xref: EC:2.6.1.38 xref: MetaCyc:HISTTRANSAM-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008111 name: alpha-methylacyl-CoA racemase activity namespace: molecular_function def: "Catalysis of the reaction: (2S)-2-methylacyl-CoA = (2R)-2-methylacyl-CoA." [EC:5.1.99.4] subset: gosubset_prok synonym: "2-methylacyl-CoA 2-epimerase activity" EXACT [EC:5.1.99.4] xref: EC:5.1.99.4 xref: MetaCyc:5.1.99.4-RXN xref: Reactome:22891 "alpha-methylacyl-CoA racemase activity" is_a: GO:0016854 ! racemase and epimerase activity [Term] id: GO:0008112 name: nicotinamide N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinamide = S-adenosyl-L-homocysteine + 1-methylnicotinamide." [EC:2.1.1.1] subset: gosubset_prok synonym: "nicotinamide methyltransferase activity" EXACT [EC:2.1.1.1] synonym: "S-adenosyl-L-methionine:nicotinamide N-methyltransferase activity" EXACT [EC:2.1.1.1] xref: EC:2.1.1.1 xref: MetaCyc:NICOTINAMIDE-N-METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008113 name: peptide-methionine-(S)-S-oxide reductase activity namespace: molecular_function alt_id: GO:0033742 def: "Catalysis of the reactions: peptide-L-methionine + thioredoxin disulfide + H2O = peptide-L-methionine (S)-S-oxide + thioredoxin and L-methionine + thioredoxin disulfide + H2O = L-methionine (S)-S-oxide + thioredoxin." [EC:1.8.4.11, PMID:11169920] subset: gosubset_prok synonym: "methionine S-oxide reductase (S-form oxidizing) activity" EXACT [EC:1.8.4.11] synonym: "methionine S-oxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulfoxide (protein) reductase activity" EXACT [] synonym: "methionine sulfoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "methionine sulfoxide reductase activity" BROAD [EC:1.8.4.11] synonym: "methionine sulphoxide reductase A activity" EXACT [EC:1.8.4.11] synonym: "MsrA" RELATED [EC:1.8.4.11] synonym: "peptide Met(O) reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide methionine sulfoxide reductase activity" EXACT [EC:1.8.4.11] synonym: "peptide-L-methionine:thioredoxin-disulfide S-oxidoreductase [L-methionine (S)-S-oxide-forming] activity" EXACT [EC:1.8.4.11] synonym: "protein-methionine-S-oxide reductase activity" EXACT [EC:1.8.4.11] xref: EC:1.8.4.11 xref: MetaCyc:RXN-8668 xref: MetaCyc:RXN-8669 is_a: GO:0016671 ! oxidoreductase activity, acting on sulfur group of donors, disulfide as acceptor [Term] id: GO:0008114 name: phosphogluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-D-gluconate + NADP+ = 6-phospho-2-dehydro-D-gluconate + NADPH." [EC:1.1.1.43] synonym: "2-keto-6-phosphogluconate reductase activity" EXACT [EC:1.1.1.43] synonym: "6-phospho-D-gluconate:NAD(P)+ 2-oxidoreductase activity" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconate 2-dehydrogenase activity" EXACT [] synonym: "6-phosphogluconate dehydrogenase (NAD)" EXACT [EC:1.1.1.43] synonym: "6-phosphogluconic dehydrogenase activity" BROAD [EC:1.1.1.43] synonym: "gluconate 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.43] synonym: "phosphogluconate dehydrogenase activity" EXACT [EC:1.1.1.43] xref: EC:1.1.1.43 xref: MetaCyc:1.1.1.43-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008115 name: sarcosine oxidase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + H2O + O2 = glycine + formaldehyde + H2O2." [EC:1.5.3.1] subset: gosubset_prok synonym: "sarcosine:oxygen oxidoreductase (demethylating)" EXACT [EC:1.5.3.1] xref: EC:1.5.3.1 xref: MetaCyc:SARCOX-RXN is_a: GO:0016647 ! oxidoreductase activity, acting on the CH-NH group of donors, oxygen as acceptor [Term] id: GO:0008116 name: prostaglandin-I synthase activity namespace: molecular_function def: "Catalysis of the reaction: (5Z,13E)-(15S)-9-alpha,11-alpha-epidioxy-15-hydroxyprosta-5,13-dienoate = (5Z,13E)-(15S)-6,9-alpha-epoxy-11-alpha,15-dihydroxyprosta-5,13-dienoate." [EC:5.3.99.4] synonym: "(5Z,13E)-(15S)-9alpha,11alpha-epidioxy-15-hydroxyprosta-5,13-dienoate 6-isomerase activity" EXACT [EC:5.3.99.4] synonym: "cytochrome P450 CYP8A1" NARROW [] synonym: "PGI(2) synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI(2) synthetase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthase activity" EXACT [EC:5.3.99.4] synonym: "PGI2 synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostacyclin synthase activity" EXACT [EC:5.3.99.4] synonym: "prostacycline synthetase activity" EXACT [EC:5.3.99.4] synonym: "prostagladin I2 synthetase activity" EXACT [EC:5.3.99.4] xref: EC:5.3.99.4 xref: MetaCyc:PROSTAGLANDIN-I-SYNTHASE-RXN xref: Reactome:22900 "prostaglandin-I synthase activity" is_a: GO:0016860 ! intramolecular oxidoreductase activity [Term] id: GO:0008117 name: sphinganine-1-phosphate aldolase activity namespace: molecular_function alt_id: GO:0016001 def: "Catalysis of the reaction: sphinganine 1-phosphate = phosphoethanolamine + palmitaldehyde." [EC:4.1.2.27] subset: gosubset_prok synonym: "dihydrosphingosine 1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate alkanal-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming)" EXACT [EC:4.1.2.27] synonym: "sphinganine-1-phosphate palmitaldehyde-lyase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate aldolase activity" EXACT [EC:4.1.2.27] synonym: "sphingosine-1-phosphate lyase activity" EXACT [EC:4.1.2.27] xref: EC:4.1.2.27 xref: MetaCyc:SPHINGANINE-1-PHOSPHATE-ALDOLASE-RXN xref: Reactome:22901 "sphinganine-1-phosphate aldolase activity" is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008118 name: N-acetyllactosaminide alpha-2,3-sialyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CMP-N-acetylneuraminate + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein = CMP + alpha-N-acetylneuraminyl-2,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein." [EC:2.4.99.6] synonym: "alpha2->3 sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "CMP-N-acetylneuraminate:beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-glycoprotein alpha-2,3-N-acetylneuraminyltransferase activity" EXACT [EC:2.4.99.6] synonym: "cytidine monophosphoacetylneuraminate-beta-galactosyl(1->4)acetylglucosaminide alpha2->3-sialyltransferase activity" EXACT [EC:2.4.99.6] synonym: "SiaT" RELATED [EC:2.4.99.6] xref: EC:2.4.99.6 xref: MetaCyc:2.4.99.6-RXN is_a: GO:0008373 ! sialyltransferase activity [Term] id: GO:0008119 name: thiopurine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + a thiopurine = S-adenosyl-L-homocysteine + a thiopurine S-methylether." [EC:2.1.1.67] subset: gosubset_prok synonym: "6-thiopurine transmethylase activity" EXACT [EC:2.1.1.67] synonym: "mercaptopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "S-adenosyl-L-methionine:thiopurine S-methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "thiopurine methyltransferase activity" EXACT [EC:2.1.1.67] synonym: "TPMT" RELATED [EC:2.1.1.67] xref: EC:2.1.1.67 xref: MetaCyc:THIOPURINE-S-METHYLTRANSFERASE-RXN xref: Reactome:22905 "thiopurine S-methyltransferase activity" is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008120 name: ceramide glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + N-acylsphingosine = UDP + D-glucosyl-N-acylsphingosine." [EC:2.4.1.80] subset: gosubset_prok synonym: "ceramide:UDP-glucose glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "ceramide:UDPGlc glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "glucosylceramide synthase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDP-glucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "UDPglucose:N-acylsphingosine D-glucosyltransferase activity" EXACT [EC:2.4.1.80] synonym: "uridine diphosphoglucose-ceramide glucosyltransferase activity" EXACT [EC:2.4.1.80] xref: EC:2.4.1.80 xref: MetaCyc:CERAMIDE-GLUCOSYLTRANSFERASE-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008121 name: ubiquinol-cytochrome-c reductase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: CoQH2 + 2 ferricytochrome c = CoQ + 2 ferrocytochrome c + 2 H+." [EC:1.10.2.2, ISBN:0198547684] subset: gosubset_prok synonym: "coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "coenzyme QH2-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "complex III (mitochondrial electron transport) activity" NARROW [EC:1.10.2.2] synonym: "CoQH2-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "cytochrome bc1 complex" RELATED [] synonym: "dihydrocoenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "mitochondrial electron transport complex III" RELATED [EC:1.10.2.2] synonym: "QH2:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced coenzyme Q-cytochrome c reductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "reduced ubiquinone-cytochrome c reductase, complex III (mitochondrial electron transport)" RELATED [EC:1.10.2.2] synonym: "ubihydroquinol:cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c-2 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c1 oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol-cytochrome c2 reductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinol:ferricytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone--cytochrome-c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome b-c1 oxidoreductase activity" EXACT [] synonym: "ubiquinone-cytochrome c oxidoreductase activity" EXACT [EC:1.10.2.2] synonym: "ubiquinone-cytochrome c reductase activity" EXACT [EC:1.10.2.2] xref: EC:1.10.2.2 xref: MetaCyc:1.10.2.2-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0016681 ! oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor [Term] id: GO:0008123 name: cholesterol 7-alpha-monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + NADPH + H+ + O2 = 7-alpha-hydroxycholesterol + NADP+ + H2O." [EC:1.14.13.17] synonym: "cholesterol 7-alpha-hydroxylase activity" EXACT [] synonym: "cholesterol 7alpha-hydroxylase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol 7alpha-monooxygenase activity" EXACT [EC:1.14.13.17] synonym: "cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)" EXACT [EC:1.14.13.17] synonym: "cytochrome P450 CYP7A1" NARROW [] xref: EC:1.14.13.17 xref: MetaCyc:CHOLESTEROL-7-ALPHA-MONOOXYGENASE-RXN xref: Reactome:22932 "cholesterol 7-alpha-monooxygenase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008124 name: 4-alpha-hydroxytetrahydrobiopterin dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4-alpha-hydroxypterin = (6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin + H2O." [EC:4.2.1.96] subset: gosubset_prok synonym: "(6R)-6-(L-erythro-1,2-dihydroxypropyl)-5,6,7,8-tetrahydro-4a-hydroxypterin hydro-lyase [(6R)-6-(L-erythro-1,2-dihydroxypropyl)-7,8-dihydro-6H-pterin-forming]" RELATED [EC:4.2.1.96] synonym: "4-alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "4a-hydroxytetrahydrobiopterin dehydratase activity" EXACT [] synonym: "4a-hydroxytetrahydrobiopterin hydro-lyase activity" EXACT [EC:4.2.1.96] synonym: "4alpha-hydroxy-tetrahydropterin dehydratase activity" EXACT [EC:4.2.1.96] synonym: "pterin-4-alpha-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4a-carbinolamine dehydratase activity" EXACT [] synonym: "pterin-4alpha-carbinolamine dehydratase activity" EXACT [EC:4.2.1.96] synonym: "tetrahydrobiopterin dehydratase activity" EXACT [EC:4.2.1.96] xref: EC:4.2.1.96 xref: MetaCyc:RXN-7908 xref: Reactome:22934 "4-alpha-hydroxytetrahydrobiopterin dehydratase activity" is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008125 name: pancreatic elastase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin. Preferential cleavage: Ala-Xaa." [EC:3.4.21.36] comment: This term was made obsolete because it represents a gene product. synonym: "elaszym" RELATED [EC:3.4.21.36] synonym: "pancreatopeptidase E activity" EXACT [EC:3.4.21.36] synonym: "serine elastase" BROAD [EC:3.4.21.36] xref: EC:3.4.21.36 xref: MetaCyc:3.4.21.36-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008126 name: acetylesterase activity namespace: molecular_function def: "Catalysis of the reaction: an acetic ester + H2O = an alcohol + acetate." [EC:3.1.1.6] subset: gosubset_prok synonym: "acetic ester hydrolase activity" EXACT [EC:3.1.1.6] synonym: "acetic-ester acetylhydrolase activity" EXACT [EC:3.1.1.6] synonym: "C-esterase (in animal tissues)" NARROW [EC:3.1.1.6] synonym: "chloroesterase" NARROW [EC:3.1.1.6] synonym: "citrus acetylesterase" NARROW [EC:3.1.1.6] synonym: "p-nitrophenyl acetate esterase" NARROW [EC:3.1.1.6] xref: EC:3.1.1.6 xref: MetaCyc:ACETYLESTERASE-RXN xref: UM-BBD_enzymeID:e0052 is_a: GO:0034338 ! short-chain carboxylesterase activity [Term] id: GO:0008127 name: quercetin 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: quercetin + O2 = 2-protocatechuoylphloroglucinolcarboxylate + CO." [EC:1.13.11.24] synonym: "flavonol 2,4-oxygenase activity" EXACT [EC:1.13.11.24] synonym: "quercetin:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.24] synonym: "quercetinase activity" EXACT [EC:1.13.11.24] xref: EC:1.13.11.24 xref: MetaCyc:QUERCETIN-23-DIOXYGENASE-RXN xref: UM-BBD_enzymeID:e0559 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008129 name: actinidain activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins with broad specificity for peptide bonds, with preference for a residue bearing a large hydrophobic side chain at the P2 position. Does not accept Val at P1'." [EC:3.4.22.14] comment: This term was made obsolete because it represents a gene product. synonym: "actinidia anionic protease activity" NARROW [EC:3.4.22.14] synonym: "actinidin activity" EXACT [EC:3.4.22.14] synonym: "proteinase A2 of actinidia chinensis" RELATED [EC:3.4.22.14] xref: EC:3.4.22.14 xref: MetaCyc:3.4.22.14-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008130 name: neutrophil collagenase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of interstitial collagens in the triple helical domain. Unlike EC:3.4.24.7, this enzyme cleaves type III collagen more slowly than type I." [EC:3.4.24.34] comment: This term was made obsolete because it represents a gene product. synonym: "matrix metalloproteinase 8 activity" EXACT [EC:3.4.24.34] synonym: "MMP-8" EXACT [] synonym: "PMNL collagenase activity" EXACT [EC:3.4.24.34] xref: EC:3.4.24.34 xref: MetaCyc:3.4.24.34-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008131 name: amine oxidase activity namespace: molecular_function alt_id: GO:0004041 alt_id: GO:0008122 def: "Catalysis of the reaction: R-CH2-NH2 + H2O + O2 = R-CHO + NH3 + H2O2." [EC:1.4.3.21, EC:1.4.3.22, EC:1.4.3.4] subset: gosubset_prok synonym: "adrenalin oxidase" NARROW [EC:1.4.3.4] synonym: "adrenaline oxidase activity" NARROW [EC:1.4.3.4] synonym: "amine oxidase (copper-containing) activity" NARROW [] synonym: "amine oxidase (flavin-containing) activity" NARROW [] synonym: "amine oxidase (pyridoxal containing)" NARROW [EC:1.4.3.4] synonym: "amine oxygen oxidoreductase activity" EXACT [EC:1.4.3.4] synonym: "amine:oxygen oxidoreductase (deaminating) (flavin-containing)" NARROW [EC:1.4.3.4] synonym: "benzylamine oxidase" NARROW [EC:1.4.3.4] synonym: "Cu-amine oxidase activity" RELATED [EC:1.4.3.21] synonym: "DAO activity" NARROW [EC:1.4.3.4] synonym: "diamine oxidase activity" RELATED [EC:1.4.3.22] synonym: "diamino oxhydrase activity" NARROW [EC:1.4.3.4] synonym: "epinephrine oxidase" NARROW [EC:1.4.3.4] synonym: "histaminase activity" NARROW [EC:1.4.3.22] synonym: "histamine deaminase" NARROW [EC:1.4.3.21] synonym: "histamine oxidase" NARROW [EC:1.4.3.21] synonym: "MAO" RELATED [EC:1.4.3.4] synonym: "monoamine oxidase activity" NARROW [EC:1.4.3.4] synonym: "monoamine:O2 oxidoreductase (deaminating)" NARROW [EC:1.4.3.4] synonym: "semicarbazide-sensitive amine oxidase" NARROW [EC:1.4.3.22] synonym: "serotonin deaminase" NARROW [EC:1.4.3.4] synonym: "spermidine oxidase" NARROW [EC:1.4.3.4] synonym: "spermine oxidase" NARROW [EC:1.4.3.4] synonym: "SSAO" RELATED [EC:1.4.3.4] synonym: "tyraminase activity" NARROW [EC:1.4.3.4] synonym: "tyramine oxidase activity" NARROW [EC:1.4.3.4] xref: EC:1.4.3.21 xref: EC:1.4.3.22 xref: EC:1.4.3.4 xref: MetaCyc:AMINEOXID-RXN xref: Reactome:7141 "amine oxidase activity" is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0008132 name: pancreatic elastase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins, including elastin." [EC:3.4.21.36, EC:3.4.21.71] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008133 name: collagenase activity namespace: molecular_function def: "OBSOLETE. Was not defined before being made obsolete." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008134 name: transcription factor binding namespace: molecular_function def: "Interacting selectively and non-covalently with a transcription factor, any protein required to initiate or regulate transcription." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "TF binding" EXACT [] is_a: GO:0005515 ! protein binding [Term] id: GO:0008135 name: translation factor activity, nucleic acid binding namespace: molecular_function def: "Functions during translation by binding nucleic acids during polypeptide synthesis at the ribosome." [GOC:ai] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0003676 ! nucleic acid binding relationship: part_of GO:0006412 ! translation [Term] id: GO:0008137 name: NADH dehydrogenase (ubiquinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + ubiquinone = NAD+ + ubiquinol." [EC:1.6.5.3] subset: gosubset_prok synonym: "coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "complex 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "complex I (electron transport chain) activity" RELATED [EC:1.6.5.3] synonym: "complex I (mitochondrial electron transport) activity" RELATED [EC:1.6.5.3] synonym: "complex I (NADH:Q1 oxidoreductase) activity" RELATED [EC:1.6.5.3] synonym: "dihydronicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "DPNH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "electron transfer complex I activity" RELATED [EC:1.6.5.3] synonym: "mitochondrial electron transport complex 1 activity" NARROW [EC:1.6.5.3] synonym: "mitochondrial electron transport complex I activity" NARROW [EC:1.6.5.3] synonym: "NADH coenzyme Q1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-CoQ reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-Q6 oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH-ubiquinone-1 reductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase activity" EXACT [EC:1.6.5.3] synonym: "NADH:ubiquinone oxidoreductase complex activity" RELATED [EC:1.6.5.3] synonym: "reduced nicotinamide adenine dinucleotide-coenzyme Q reductase activity" EXACT [EC:1.6.5.3] synonym: "type 1 dehydrogenase activity" RELATED [EC:1.6.5.3] synonym: "ubiquinone reductase activity" EXACT [] xref: EC:1.6.5.3 xref: MetaCyc:NADH-DEHYDROG-A-RXN xref: MetaCyc:RXN0-5330 xref: Reactome:22973 "NADH dehydrogenase (ubiquinone) activity" is_a: GO:0050136 ! NADH dehydrogenase (quinone) activity [Term] id: GO:0008138 name: protein tyrosine/serine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein serine/threonine/tyrosine phosphate + H2O = protein serine/threonine/tyrosine + phosphate." [GOC:mah] subset: gosubset_prok synonym: "dual-specificity protein phosphatase" BROAD [] xref: EC:3.1.3.- is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008139 name: nuclear localization sequence binding namespace: molecular_function def: "Interacting selectively and non-covalently with a nuclear localization sequence, a specific peptide sequence that acts as a signal to localize the protein within the nucleus." [GOC:ai] synonym: "NLS binding" EXACT [] synonym: "nuclear localization signal binding" EXACT [] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0008140 name: cAMP response element binding protein binding namespace: molecular_function synonym: "3',5' cAMP response element binding protein binding" EXACT [] synonym: "3',5'-cAMP response element binding protein binding" EXACT [] synonym: "adenosine 3',5'-cyclophosphate response element binding protein binding" EXACT [] synonym: "cyclic AMP response element binding protein binding" EXACT [] is_a: GO:0003713 ! transcription coactivator activity [Term] id: GO:0008141 name: puparial glue (sensu Diptera) namespace: molecular_function def: "OBSOLETE. A glue which attaches the pupae to the substrate during metamorphosis, as in, but not restricted to, the true flies (Diptera, ncbi_taxonomy_id:7147)." [PMID:825230] comment: This term was made obsolete because it represents a gene product and not a molecular function. is_obsolete: true replaced_by: GO:0005198 replaced_by: GO:0007594 [Term] id: GO:0008142 name: oxysterol binding namespace: molecular_function def: "Interacting selectively and non-covalently with oxysterol, an oxidized form of cholesterol." [http://www.onelook.com/] is_a: GO:0032934 ! sterol binding [Term] id: GO:0008143 name: poly(A) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of adenylyl residues in an RNA molecule, such as the poly(A) tail, a sequence of adenylyl residues at the 3' end of eukaryotic mRNA." [GOC:krc, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "poly(A) binding" EXACT [GOC:mah] synonym: "poly(rA) binding" EXACT [GOC:mah] synonym: "poly-A binding" BROAD [GOC:mah] synonym: "polyadenylate binding" BROAD [GOC:mah] is_a: GO:0003729 ! mRNA binding is_a: GO:0070717 ! poly-purine tract binding [Term] id: GO:0008144 name: drug binding namespace: molecular_function def: "Interacting selectively and non-covalently with a drug, any naturally occurring or synthetic substance, other than a nutrient, that, when administered or applied to an organism, affects the structure or functioning of the organism; in particular, any such substance used in the diagnosis, prevention, or treatment of disease." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008145 name: phenylalkylamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phenylalkylamine or any of its derivatives." [GOC:jl] is_a: GO:0008144 ! drug binding [Term] id: GO:0008146 name: sulfotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate to the hydroxyl group of an acceptor, producing the sulfated derivative and 3'-phosphoadenosine 5'-phosphate." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "sulphotransferase activity" EXACT [] xref: EC:2.8.2 xref: Reactome:2397 "sulfotransferase activity" is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008147 name: structural constituent of bone namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of bone." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008148 name: negative transcription elongation factor activity namespace: molecular_function def: "Any activity that decreases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] is_a: GO:0003711 ! transcription elongation regulator activity [Term] id: GO:0008149 name: para-aminobenzoic acid (PABA) synthase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai, MetaCyc:PABASYN-CPLX] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008150 name: biological_process namespace: biological_process alt_id: GO:0000004 alt_id: GO:0007582 def: "Any process specifically pertinent to the functioning of integrated living units: cells, tissues, organs, and organisms. A process is a collection of molecular events with a defined beginning and end." [GOC:go_curators, GOC:isa_complete] comment: Note that, in addition to forming the root of the biological process ontology, this term is recommended for use for the annotation of gene products whose biological process is unknown. Note that when this term is used for annotation, it indicates that no information was available about the biological process of the gene product annotated as of the date the annotation was made; the evidence code ND, no data, is used to indicate this. subset: goslim_candida subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok synonym: "biological process" EXACT [] synonym: "biological process unknown" NARROW [] synonym: "physiological process" EXACT [] xref: Wikipedia:Biological_process disjoint_from: GO:0003674 ! molecular_function disjoint_from: GO:0005575 ! cellular_component [Term] id: GO:0008152 name: metabolic process namespace: biological_process def: "The chemical reactions and pathways, including anabolism and catabolism, by which living organisms transform chemical substances. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation." [GOC:go_curators, ISBN:0198547684] comment: Note that metabolic processes do not include single functions or processes such as protein-protein interactions, protein-nucleic acids, nor receptor-ligand interactions. subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "metabolic process resulting in cell growth" NARROW [] synonym: "metabolism" EXACT [] synonym: "metabolism resulting in cell growth" NARROW [] xref: Wikipedia:Metabolism is_a: GO:0008150 ! biological_process [Term] id: GO:0008153 name: para-aminobenzoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of para-aminobenzoic acid, an intermediate in the synthesis of folic acid, a compound which some organisms, e.g. prokaryotes, eukaryotic microbes, and plants, can synthesize de novo. Others, notably mammals, cannot. In yeast, it is present as a factor in the B complex of vitamins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", PMID:11377864, PMID:11960743] subset: gosubset_prok synonym: "4-aminobenzoic acid biosynthesis" EXACT [] synonym: "4-aminobenzoic acid biosynthetic process" EXACT [] synonym: "p-aminobenzoic acid biosynthesis" EXACT [] synonym: "p-aminobenzoic acid biosynthetic process" EXACT [] synonym: "PABA biosynthesis" EXACT [] synonym: "PABA biosynthetic process" EXACT [] synonym: "para-aminobenzoic acid anabolism" EXACT [] synonym: "para-aminobenzoic acid biosynthesis" EXACT [] synonym: "para-aminobenzoic acid formation" EXACT [] synonym: "para-aminobenzoic acid synthesis" EXACT [] synonym: "vitamin Bx biosynthesis" EXACT [] synonym: "vitamin Bx biosynthetic process" EXACT [] is_a: GO:0009396 ! folic acid and derivative biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process is_a: GO:0046482 ! para-aminobenzoic acid metabolic process [Term] id: GO:0008154 name: actin polymerization or depolymerization namespace: biological_process def: "Assembly or disassembly of actin filaments by the addition or removal of actin monomers from a filament." [GOC:mah] is_a: GO:0007015 ! actin filament organization is_a: GO:0034621 ! cellular macromolecular complex subunit organization [Term] id: GO:0008155 name: larval behavior (sensu Drosophila) namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. is_obsolete: true replaced_by: GO:0030537 [Term] id: GO:0008156 name: negative regulation of DNA replication namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of DNA replication." [GOC:go_curators] subset: gosubset_prok synonym: "DNA replication inhibitor" RELATED [] synonym: "down regulation of DNA replication" EXACT [] synonym: "down-regulation of DNA replication" EXACT [] synonym: "downregulation of DNA replication" EXACT [] synonym: "inhibition of DNA replication" NARROW [] is_a: GO:0006275 ! regulation of DNA replication is_a: GO:0010558 ! negative regulation of macromolecule biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0051053 ! negative regulation of DNA metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006260 ! DNA replication relationship: negatively_regulates GO:0006260 ! DNA replication [Term] id: GO:0008157 name: protein phosphatase 1 binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme protein phosphatase 1." [GOC:jl] is_a: GO:0019903 ! protein phosphatase binding [Term] id: GO:0008158 name: hedgehog receptor activity namespace: molecular_function def: "Combining with the hedgehog protein to initiate a change in cell activity." [GOC:go_curators] synonym: "patched activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008159 name: positive transcription elongation factor activity namespace: molecular_function def: "Any activity that increases the rate of transcription elongation, the addition of ribonucleotides to an RNA molecule following transcription initiation." [GOC:mah] is_a: GO:0003711 ! transcription elongation regulator activity [Term] id: GO:0008160 name: protein tyrosine phosphatase activator activity namespace: molecular_function def: "Increases the activity of a phosphatase, an enzyme which catalyzes of the removal of a phosphate group from a tyrosyl phenolic group of a protein." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0019211 ! phosphatase activator activity relationship: positively_regulates GO:0004725 ! protein tyrosine phosphatase activity [Term] id: GO:0008161 name: carbamate resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046681 [Term] id: GO:0008162 name: cyclodiene resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046682 [Term] id: GO:0008163 name: DDT resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046680 [Term] id: GO:0008164 name: organophosphorus resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046683 [Term] id: GO:0008165 name: pyrethroid resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0046684 [Term] id: GO:0008166 name: viral replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it covers multiple processes and is now covered by more specific terms. is_obsolete: true consider: GO:0019079 [Term] id: GO:0008167 name: sigma virus replication namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] is_obsolete: true replaced_by: GO:0019079 [Term] id: GO:0008168 name: methyltransferase activity namespace: molecular_function alt_id: GO:0004480 def: "Catalysis of the transfer of a methyl group to an acceptor molecule." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methylase" BROAD [] xref: EC:2.1.1 xref: Reactome:1062 "methyltransferase activity" is_a: GO:0016741 ! transferase activity, transferring one-carbon groups relationship: part_of GO:0032259 ! methylation [Term] id: GO:0008169 name: C-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carbon atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008170 name: N-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the nitrogen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008171 name: O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008172 name: S-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the sulfur atom of an acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.1.1.- xref: Reactome:9949 "S-methyltransferase activity" is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008173 name: RNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule." [GOC:mah] comment: Note that the methyl donor is usually S-adenosyl-L-methionine, but there is at least one exception (see GO:0030698). subset: gosubset_prok xref: EC:2.1.1.- xref: Reactome:1979 "RNA methyltransferase activity" is_a: GO:0008168 ! methyltransferase activity relationship: part_of GO:0001510 ! RNA methylation [Term] id: GO:0008174 name: mRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity relationship: part_of GO:0080009 ! mRNA methylation [Term] id: GO:0008175 name: tRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in a tRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity relationship: part_of GO:0030488 ! tRNA methylation [Term] id: GO:0008176 name: tRNA (guanine-N7-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N7-methylguanine." [EC:2.1.1.33] subset: gosubset_prok synonym: "7-methylguanine transfer ribonucleate methylase activity" EXACT [EC:2.1.1.33] synonym: "N7-methylguanine methylase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-7-N-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N7-)-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "transfer ribonucleate guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] synonym: "tRNA guanine 7-methyltransferase activity" EXACT [EC:2.1.1.33] xref: EC:2.1.1.33 xref: MetaCyc:TRNA-GUANINE-N7--METHYLTRANSFERASE-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0008177 name: succinate dehydrogenase (ubiquinone) activity namespace: molecular_function alt_id: GO:0019737 def: "Catalysis of the reaction: succinate + quinone = fumarate + quinol." [EC:1.3.5.1] subset: gosubset_prok synonym: "complex II" RELATED [EC:1.3.5.1] synonym: "fumarate reductase complex (i.e. FRD, involved in anaerobic respiration, repressed in aerobic respiration)" RELATED [EC:1.3.5.1] synonym: "menaquinol: fumarate oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "quinol:fumarate oxidoreductase activity" EXACT [] synonym: "succinate dehydrogenase complex (i. e. SDH, involved in aerobic respiration, repressed in anaerobic respiration)" RELATED [EC:1.3.5.1] synonym: "succinate:ubiquinone oxidoreductase activity" EXACT [EC:1.3.5.1] synonym: "succinic dehydrogenase activity" BROAD [EC:1.3.5.1] xref: EC:1.3.5.1 xref: MetaCyc:SUCCINATE-DEHYDROGENASE-UBIQUINONE-RXN xref: Reactome:23070 "succinate dehydrogenase (ubiquinone) activity" is_a: GO:0000104 ! succinate dehydrogenase activity is_a: GO:0016635 ! oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor [Term] id: GO:0008179 name: adenylate cyclase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme adenylate cyclase." [GOC:jl] synonym: "adenylyl cyclase binding" EXACT [] xref: Reactome:23073 "adenylate cyclase binding" is_a: GO:0019899 ! enzyme binding [Term] id: GO:0008180 name: signalosome namespace: cellular_component def: "A protein complex that catalyzes the deneddylation of proteins, including the cullin component of SCF ubiquitin E3 ligase; deneddylation increases the activity of cullin family ubiquitin ligases. The signalosome is involved in many regulatory process, including some which control development, in many species; also regulates photomorphogenesis in plants; in many species its subunits are highly similar to those of the proteasome." [PMID:11019806, PMID:12186635, PMID:14570571] synonym: "COP9 complex" NARROW [] synonym: "CSN" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044428 ! nuclear part [Term] id: GO:0008181 name: tumor suppressor namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it does not represent a true biological function, rather a pathology that occurs when a particular gene product is inactivated in some way. is_obsolete: true consider: GO:0051726 [Term] id: GO:0008184 name: glycogen phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: glycogen + phosphate = maltodextrin + alpha-D-glucose 1-phosphate." [EC:2.4.1.1, MetaCyc:GLYCOPHOSPHORYL-RXN] subset: gosubset_prok xref: MetaCyc:GLYCOPHOSPHORYL-RXN xref: Reactome:23099 "glycogen phosphorylase activity" is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0008186 name: RNA-dependent ATPase activity namespace: molecular_function alt_id: GO:0004010 def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of RNA; drives another reaction." [EC:3.6.1.3, GOC:jl] subset: gosubset_prok synonym: "RNA-dependent adenosinetriphosphatase activity" EXACT [] is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008187 name: poly-pyrimidine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with any stretch of pyrimidines (cytosine or uracil) in an RNA molecule." [GOC:jl] is_a: GO:0003727 ! single-stranded RNA binding [Term] id: GO:0008188 name: neuropeptide receptor activity namespace: molecular_function def: "Combining with a neuropeptide to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled is_a: GO:0030594 ! neurotransmitter receptor activity is_a: GO:0042923 ! neuropeptide binding relationship: part_of GO:0007218 ! neuropeptide signaling pathway [Term] id: GO:0008189 name: apoptosis inhibitor activity namespace: molecular_function def: "OBSOLETE. The function held by products which directly block any step in the process of apoptosis." [GOC:hb] comment: This term was made obsolete because it represents involvement in a biological process. is_obsolete: true replaced_by: GO:0006916 [Term] id: GO:0008190 name: eukaryotic initiation factor 4E binding namespace: molecular_function def: "Interacting selectively and non-covalently with eukaryotic initiation factor 4E, a polypeptide factor involved in the initiation of ribosome-mediated translation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "eIF4E binding" EXACT [] is_a: GO:0031369 ! translation initiation factor binding [Term] id: GO:0008191 name: metalloendopeptidase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of metalloendopeptidases, enzymes that catalyze the hydrolysis of nonterminal peptide bonds in a polypeptide chain and contain a chelated metal ion at their active sites which is essential to their catalytic activity." [GOC:ai] subset: gosubset_prok synonym: "metalloprotease inhibitor" BROAD [] synonym: "metalloproteinase inhibitor" BROAD [] is_a: GO:0004866 ! endopeptidase inhibitor activity is_a: GO:0048551 ! metalloenzyme inhibitor activity relationship: negatively_regulates GO:0004222 ! metalloendopeptidase activity [Term] id: GO:0008192 name: RNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of an RNA molecule." [GOC:mah] xref: EC:2.7.7.- is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008193 name: tRNA guanylyltransferase activity namespace: molecular_function def: "Catalysis of the posttranscriptional addition of a guanyl residue to the 5' end of a tRNA molecule; observed for His tRNAs." [PMID:1660461] xref: EC:2.7.7.- is_a: GO:0008192 ! RNA guanylyltransferase activity [Term] id: GO:0008194 name: UDP-glycosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a glycosyl group from a UDP-sugar to a small hydrophobic molecule." [InterPro:IPR004224, PMID:11846783] subset: gosubset_prok xref: Reactome:23123 "UDP-glycosyltransferase activity" is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008195 name: phosphatidate phosphatase activity namespace: molecular_function alt_id: GO:0004606 def: "Catalysis of the reaction: a 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate." [EC:3.1.3.4] synonym: "3-sn-phosphatidate phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "acid phosphatidyl phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphatase activity" EXACT [EC:3.1.3.4] synonym: "phosphatic acid phosphohydrolase activity" EXACT [EC:3.1.3.4] synonym: "phosphatidate phosphohydrolase activity" EXACT [] synonym: "phosphatidic acid phosphatase activity" EXACT [EC:3.1.3.4] xref: EC:3.1.3.4 xref: MetaCyc:PHOSPHATIDATE-PHOSPHATASE-RXN xref: Reactome:23125 "phosphatidate phosphatase activity" is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008196 name: vitellogenin receptor activity namespace: molecular_function def: "Combining with vitellogenin to initiate a change in cell activity." [GOC:ai] is_a: GO:0004872 ! receptor activity [Term] id: GO:0008197 name: yolk protein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true consider: GO:0005198 consider: GO:0045735 [Term] id: GO:0008198 name: ferrous iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferrous iron, Fe(II)." [GOC:ai] subset: gosubset_prok is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008199 name: ferric iron binding namespace: molecular_function def: "Interacting selectively and non-covalently with ferric iron, Fe(III)." [GOC:ai] subset: gosubset_prok is_a: GO:0005506 ! iron ion binding [Term] id: GO:0008200 name: ion channel inhibitor activity namespace: molecular_function def: "Stops, prevents, or reduces the activity of an ion channel." [GOC:mah] subset: gosubset_prok is_a: GO:0016248 ! channel inhibitor activity relationship: negatively_regulates GO:0005216 ! ion channel activity [Term] id: GO:0008201 name: heparin binding namespace: molecular_function def: "Interacting selectively and non-covalently with heparin, any member of a group of glycosaminoglycans found mainly as an intracellular component of mast cells and which consist predominantly of alternating alpha1-4-linked D-galactose and N-acetyl-D-glucosamine-6-sulfate residues." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "heparan sulfate binding" RELATED [] is_a: GO:0005539 ! glycosaminoglycan binding [Term] id: GO:0008202 name: steroid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus." [ISBN:0198547684] subset: gosubset_prok synonym: "steroid metabolism" EXACT [] xref: Reactome:192076 "Steroid metabolism" xref: Reactome:562523 "Steroid metabolism" xref: Reactome:588149 "Steroid metabolism" xref: Reactome:608917 "Steroid metabolism" xref: Reactome:633599 "Steroid metabolism" xref: Reactome:645231 "Steroid metabolism" xref: Reactome:655605 "Steroid metabolism" xref: Reactome:660893 "Steroid metabolism" xref: Reactome:666676 "Steroid metabolism" xref: Reactome:672768 "Steroid metabolism" xref: Reactome:678555 "Steroid metabolism" xref: Reactome:683496 "Steroid metabolism" xref: Reactome:689699 "Steroid metabolism" xref: Reactome:701382 "Steroid metabolism" xref: Reactome:715953 "Steroid metabolism" xref: Reactome:720674 "Steroid metabolism" xref: Reactome:727903 "Steroid metabolism" xref: Reactome:731172 "Steroid metabolism" xref: Reactome:733006 "Steroid metabolism" xref: Reactome:733906 "Steroid metabolism" xref: Reactome:735566 "Steroid metabolism" xref: Reactome:736632 "Steroid metabolism" xref: Reactome:738425 "Steroid metabolism" xref: Wikipedia:Steroid_metabolism is_a: GO:0006629 ! lipid metabolic process [Term] id: GO:0008203 name: cholesterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cholesterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process [Term] id: GO:0008204 name: ergosterol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ergosterol, (22E)-ergosta-5,7,22-trien-3-beta-ol, a sterol found in ergot, yeast and moulds. It is the most important of the D provitamins and is converted to vitamin D2 on irradiation with UV light." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ergosterol metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0016128 ! phytosteroid metabolic process [Term] id: GO:0008205 name: ecdysone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ecdysone, (22R)-2-beta,3-beta,14,22,25-pentahydroxycholest-7-en-6-one, an ecdysteroid found in insects. It is the inactive prohormone of the moulting hormone ecdysterone and may have intrinsic hormonal activity at other stages of insect development." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "ecdysone metabolism" EXACT [] is_a: GO:0016125 ! sterol metabolic process is_a: GO:0045455 ! ecdysteroid metabolic process [Term] id: GO:0008206 name: bile acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving bile acids, any of a group of steroid carboxylic acids occurring in bile, where they are present as the sodium salts of their amides with glycine or taurine." [GOC:go_curators] synonym: "bile acid metabolism" EXACT [] xref: Reactome:159431 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:194068 "Metabolism of bile acids and bile salts" xref: Reactome:547083 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:562522 "Metabolism of bile acids and bile salts" xref: Reactome:574106 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:588148 "Metabolism of bile acids and bile salts" xref: Reactome:597791 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:608916 "Metabolism of bile acids and bile salts" xref: Reactome:620932 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:633598 "Metabolism of bile acids and bile salts" xref: Reactome:645230 "Metabolism of bile acids and bile salts" xref: Reactome:650144 "Cytosolic chenodeoxycholoyl-CoA or choloyl-CoA are conjugated with glycine or taurine" xref: Reactome:655604 "Metabolism of bile acids and bile salts" xref: Reactome:660892 "Metabolism of bile acids and bile salts" xref: Reactome:666675 "Metabolism of bile acids and bile salts" xref: Reactome:672767 "Metabolism of bile acids and bile salts" xref: Reactome:678558 "Metabolism of bile acids and bile salts" xref: Reactome:683495 "Metabolism of bile acids and bile salts" xref: Reactome:689698 "Metabolism of bile acids and bile salts" xref: Reactome:701381 "Metabolism of bile acids and bile salts" xref: Reactome:715952 "Metabolism of bile acids and bile salts" xref: Reactome:720673 "Metabolism of bile acids and bile salts" xref: Reactome:727902 "Metabolism of bile acids and bile salts" xref: Reactome:731189 "Metabolism of bile acids and bile salts" xref: Reactome:733005 "Metabolism of bile acids and bile salts" xref: Reactome:733953 "Metabolism of bile acids and bile salts" xref: Reactome:735565 "Metabolism of bile acids and bile salts" xref: Reactome:736631 "Metabolism of bile acids and bile salts" xref: Reactome:738424 "Metabolism of bile acids and bile salts" is_a: GO:0008202 ! steroid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0008207 name: C21-steroid hormone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008208 name: C21-steroid hormone catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones." [GOC:ai] synonym: "C21-steroid hormone breakdown" EXACT [] synonym: "C21-steroid hormone catabolism" EXACT [] synonym: "C21-steroid hormone degradation" EXACT [] is_a: GO:0006706 ! steroid catabolic process is_a: GO:0008207 ! C21-steroid hormone metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0008209 name: androgen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "androgen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008210 name: estrogen metabolic process namespace: biological_process def: "The chemical reactions and pathways involving estrogens, C18 steroid hormones that can stimulate the development of female sexual characteristics. Also found in plants." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "estrogen metabolism" EXACT [] synonym: "oestrogen metabolic process" EXACT [] synonym: "oestrogen metabolism" EXACT [] is_a: GO:0008202 ! steroid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process [Term] id: GO:0008211 name: glucocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "glucocorticoid metabolism" EXACT [] synonym: "glucocorticosteroid metabolic process" EXACT [] synonym: "glucocorticosteroid metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process [Term] id: GO:0008212 name: mineralocorticoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. Mineralocorticoids act primarily on water and electrolyte balance." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "mineralocorticoid metabolism" EXACT [] is_a: GO:0008207 ! C21-steroid hormone metabolic process [Term] id: GO:0008213 name: protein amino acid alkylation namespace: biological_process def: "The addition of an alkyl group to a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ma] subset: gosubset_prok is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0008214 name: protein amino acid dealkylation namespace: biological_process def: "The removal of an alkyl group from a protein amino acid. An alkyl group is any group derived from an alkane by removal of one hydrogen atom." [GOC:ai] subset: gosubset_prok is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0008215 name: spermine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses, which is involved in nucleic acid packaging. Synthesis is regulated by ornithine decarboxylase which plays a key role in control of DNA replication." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "spermine metabolism" EXACT [] xref: Reactome:141341 "Spermine is oxidized to spermidine" xref: Reactome:560757 "Spermine is oxidized to spermidine" xref: Reactome:586508 "Spermine is oxidized to spermidine" xref: Reactome:607510 "Spermine is oxidized to spermidine" xref: Reactome:632006 "Spermine is oxidized to spermidine" xref: Reactome:644561 "Spermine is oxidized to spermidine" xref: Reactome:654939 "Spermine is oxidized to spermidine" xref: Reactome:666350 "Spermine is oxidized to spermidine" xref: Reactome:700660 "Spermine is oxidized to spermidine" xref: Reactome:715179 "Spermine is oxidized to spermidine" is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0008216 name: spermidine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:ai] subset: gosubset_prok synonym: "spermidine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0008217 name: regulation of blood pressure namespace: biological_process def: "Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure." [GOC:dph, GOC:mtg_cardio, ISBN:0721643949 "Textbook of Medical Physiology"] synonym: "blood pressure homeostasis" RELATED [] synonym: "blood pressure regulation" EXACT [] synonym: "control of blood pressure" RELATED [] xref: Wikipedia:Blood_pressure#Regulation is_a: GO:0065008 ! regulation of biological quality relationship: part_of GO:0008015 ! blood circulation [Term] id: GO:0008218 name: bioluminescence namespace: biological_process def: "The production of light by certain enzyme-catalyzed reactions in cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Bioluminescence is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0008219 name: cell death namespace: biological_process def: "A biological process that results in permanent cessation of all vital functions of a cell." [GOC:mah] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "necrosis" RELATED [] is_a: GO:0009987 ! cellular process is_a: GO:0016265 ! death [Term] id: GO:0008220 name: necrosis namespace: biological_process def: "OBSOLETE. The processes that cause necrosis, the death of tissues, in another organism." [GOC:ma] comment: This term was made obsolete because the term has been used in the literature by groups in different areas of biology with a number of varying explicit and implicit definitions, and more appropriate terms were created. is_obsolete: true consider: GO:0001906 consider: GO:0008219 consider: GO:0012501 consider: GO:0019835 [Term] id: GO:0008222 name: tumor antigen namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product, and because describing something as an 'antigen' means that an organism can produce antibodies to it, which says nothing about the gene product activity. is_obsolete: true [Term] id: GO:0008224 name: Gram-positive antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-positive bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050830 [Term] id: GO:0008225 name: Gram-negative antibacterial peptide activity namespace: molecular_function def: "OBSOLETE. Inhibits the growth of, or directly kills, Gram-negative bacterial cells." [GOC:go_curators] comment: This term was made obsolete because it describes involvement in a process and not a function. is_obsolete: true consider: GO:0050829 [Term] id: GO:0008226 name: tyramine receptor activity namespace: molecular_function def: "Combining with the biogenic amine tyramine to initiate a change in cell activity. Tyramine is a sympathomimetic amine derived from tyrosine with an action resembling that of epinephrine." [http://www.onelook.com/] is_a: GO:0008227 ! G-protein coupled amine receptor activity [Term] id: GO:0008227 name: G-protein coupled amine receptor activity namespace: molecular_function def: "A receptor that binds an extracellular amine and transmits the signal to a heterotrimeric G-protein complex. These receptors are characteristically seven-transmembrane receptors and are made up of hetero- or homodimers." [GOC:dph] subset: gosubset_prok synonym: "biogenic amine receptor" NARROW [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008228 name: opsonization namespace: biological_process def: "The process by which a microorganism (or other particulate material) is rendered more susceptible to phagocytosis by coating with an opsonin, a blood serum protein such as a complement component or antibody." [GOC:add, GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:068340007X "Stedman's Medical Dictionary", ISBN:0781735149 "Fundamental Immunology"] xref: Wikipedia:Opsonin is_a: GO:0002252 ! immune effector process relationship: part_of GO:0006909 ! phagocytosis [Term] id: GO:0008229 name: opsonin activity namespace: molecular_function def: "OBSOLETE. Binds to microorganisms or other particulate material (for example, foreign erythrocytes) to increase the susceptibility of the latter to phagocytosis." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true consider: GO:0003823 [Term] id: GO:0008230 name: ecdysone receptor holocomplex namespace: cellular_component def: "A heterodimeric complex containing the products of the insect genes Ecdysone receptor (EcR) and ultraspiracle (usp). Binding of ecdysone promotes association between the two subunits, and the receptor complex then initiates molting and metamorphosis by binding DNA and regulating the transcription of target genes." [GOC:bf, PMID:14592980] is_a: GO:0005667 ! transcription factor complex is_a: GO:0043235 ! receptor complex [Term] id: GO:0008231 name: repressor ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) plus an associated corepressor such as SMRTER, which represses transcription of target genes." [PMID:10488333] synonym: "repressor ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008232 name: activator ecdysone receptor complex namespace: cellular_component def: "A protein complex consisting of a heterodimer of Ecdysone receptor (EcR) and ultraspiracle (usp) bound to the ligand ecdysone, which activates transcription of target genes." [PMID:10488333] synonym: "activator ecdysone receptor holocomplex" RELATED [] is_a: GO:0008230 ! ecdysone receptor holocomplex [Term] id: GO:0008233 name: peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid." [GOC:jl, ISBN:0815332181] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_yeast subset: gosubset_prok synonym: "hydrolase, acting on peptide bonds" EXACT [] synonym: "peptide hydrolase activity" EXACT [] synonym: "protease activity" EXACT [] synonym: "proteinase activity" EXACT [] xref: EC:3.4 xref: Reactome:1687 "peptidase activity" is_a: GO:0016787 ! hydrolase activity [Term] id: GO:0008234 name: cysteine-type peptidase activity namespace: molecular_function alt_id: GO:0004220 def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] subset: gosubset_prok synonym: "cysteine protease activity" EXACT [] synonym: "thiol protease activity" EXACT [] xref: EC:3.4.-.- is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008235 name: metalloexopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE] subset: gosubset_prok is_a: GO:0008237 ! metallopeptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008236 name: serine-type peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine)." [http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE, ISBN:0716720094] subset: gosubset_prok synonym: "serine protease activity" EXACT [] is_a: GO:0017171 ! serine hydrolase activity is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008237 name: metallopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions." [GOC:mah, http://merops.sanger.ac.uk/about/about_9.htm#CATTYPE] subset: gosubset_prok synonym: "metalloprotease activity" EXACT [GOC:mah] synonym: "metalloproteinase activity" EXACT [GOC:mah] xref: Reactome:1795 "metallopeptidase activity" is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008238 name: exopeptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of a peptide bond not more than three residues from the N- or C-terminus of a polypeptide chain, in a reaction that requires a free N-terminal amino group, C-terminal carboxyl group or both." [http://merops.sanger.ac.uk/about/about_9.htm#EXOPEPTIDASE] subset: gosubset_prok synonym: "exoprotease activity" EXACT [] is_a: GO:0070011 ! peptidase activity, acting on L-amino acid peptides [Term] id: GO:0008239 name: dipeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of N-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008240 name: tripeptidyl-peptidase activity namespace: molecular_function def: "Catalysis of the release of an N-terminal tripeptide from a polypeptide." [GOC:mah] xref: EC:3.4.14.- xref: MetaCyc:3.4.14.10-RXN xref: MetaCyc:3.4.14.9-RXN is_a: GO:0008236 ! serine-type peptidase activity is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008241 name: peptidyl-dipeptidase activity namespace: molecular_function def: "Catalysis of the release of C-terminal dipeptides from a polypeptide chain." [GOC:mb] subset: gosubset_prok xref: EC:3.4.15 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008242 name: omega peptidase activity namespace: molecular_function def: "Catalysis of the removal of terminal peptide residues that are substituted, cyclized or linked by isopeptide bonds (peptide linkages other than those of alpha-carboxyl to alpha-amino groups)." [EC:3.4.19.-] subset: gosubset_prok synonym: "peptidase activity, acting on peptides containing modified amino acids" RELATED [] xref: EC:3.4.19 is_a: GO:0008238 ! exopeptidase activity [Term] id: GO:0008243 name: plasminogen activator activity namespace: molecular_function alt_id: GO:0004296 alt_id: GO:0004297 def: "OBSOLETE. Catalysis of the specific cleavage of an Arg-Val bond in plasminogen to form plasmin." [EC:3.4.21.68, EC:3.4.21.73] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "abbokinase activity" EXACT [EC:3.4.21.68] synonym: "cellular plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "double-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "plasminogen activator, tissue-type" RELATED [EC:3.4.21.68] synonym: "t-PA" RELATED [EC:3.4.21.68] synonym: "t-plasminogen activator activity" NARROW [] synonym: "tissue plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "tissue-type plasminogen activator activity" RELATED [EC:3.4.21.-] synonym: "tPA activity" NARROW [EC:3.4.21.-] synonym: "two-chain urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] synonym: "u-PA" RELATED [EC:3.4.21.68] synonym: "u-plasminogen activator activity" NARROW [] synonym: "uPA" RELATED [EC:3.4.21.68] synonym: "urinary esterase A" RELATED [EC:3.4.21.68] synonym: "urinary plasminogen activator activity" NARROW [EC:3.4.21.-] synonym: "urokinase activity" RELATED [EC:3.4.21.-] synonym: "urokinase plasminogen activator" RELATED [EC:3.4.21.68] synonym: "urokinase-type plasminogen activator" RELATED [EC:3.4.21.68] xref: EC:3.4.21.- xref: EC:3.4.21.68 xref: EC:3.4.21.73 xref: MetaCyc:3.4.21.68-RXN xref: MetaCyc:3.4.21.73-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008245 name: lysosomal membrane hydrogen-transporting ATPase namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "V-ATPase" RELATED [] is_obsolete: true consider: GO:0046611 [Term] id: GO:0008246 name: electron transfer flavoprotein namespace: molecular_function def: "OBSOLETE. Works in conjunction with acyl-CoA dehydrogenase to catalyze the oxidation of CoA and reduce ubiquinone. Part of the mitochondrial electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it refers to a class of gene products. synonym: "ETF" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0008247 name: 1-alkyl-2-acetylglycerophosphocholine esterase complex namespace: cellular_component def: "An enzyme complex composed of two catalytic alpha subunits, which form a catalytic dimer, and a non-catalytic, regulatory beta subunit; the catalytic dimer may be an alpha1/alpha1 or alpha2/alpha2 homodimer, or an alpha1/alpha2 heterodimer. Modulates the action of platelet-activating factor (PAF)." [GOC:jl, PMID:10542206] comment: See also the molecular function term '1-alkyl-2-acetylglycerophosphocholine esterase activity ; GO:0003847'. subset: gosubset_prok synonym: "2-acetyl-1-alkylglycerophosphocholine esterase complex" EXACT [] synonym: "platelet-activating factor acetylhydrolase complex" EXACT [] is_a: GO:0043234 ! protein complex [Term] id: GO:0008248 name: pre-mRNA splicing factor activity namespace: molecular_function def: "OBSOLETE. An activity involved in the removal of an intron from a pre-mRNA." [GOC:jl] comment: This term was made obsolete because it describes a biological process. is_obsolete: true consider: GO:0008380 [Term] id: GO:0008250 name: oligosaccharyltransferase complex namespace: cellular_component def: "A protein complex that is found in the endoplasmic reticulum membrane of eukaryotes and transfers lipid-linked oligosaccharide precursor to asparagine residues on nascent proteins. In yeast, the complex includes at least nine different subunits, whereas in mammalian cells at least three different forms of the complex have been detected." [ISBN:0879695595, PMID:15835887] synonym: "oligosaccharyl transferase complex" EXACT [] synonym: "OST complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044432 ! endoplasmic reticulum part relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0008251 name: tRNA-specific adenosine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine + H2O = inosine + NH3, in a tRNA molecule." [GOC:mah, IMG:00700] subset: gosubset_prok synonym: "tRNA-adenosine deaminase activity" EXACT [] xref: EC:3.5.4.- is_a: GO:0004000 ! adenosine deaminase activity [Term] id: GO:0008252 name: nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a nucleotide + H2O = a nucleoside + phosphate." [EC:3.1.3.31] subset: gosubset_prok synonym: "acid nucleotidase activity" EXACT [EC:3.1.3.31] synonym: "deoxyinosine-activated nucleotidase (DIAN)" EXACT [EC:3.1.3.31] synonym: "deoxyribonucleoside-activated nucleotidase (DAN)" EXACT [EC:3.1.3.31] synonym: "NSP I" RELATED [EC:3.1.3.31] synonym: "NSP II" RELATED [EC:3.1.3.31] synonym: "nucleotide phosphohydrolase activity" EXACT [EC:3.1.3.31] synonym: "nucleotide-specific phosphatase activity" EXACT [EC:3.1.3.31] xref: EC:3.1.3.31 xref: MetaCyc:NUCLEOTIDASE-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008253 name: 5'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.5] subset: gosubset_prok synonym: "5' nucleotidase activity" EXACT [] synonym: "5'-adenylic phosphatase" NARROW [EC:3.1.3.5] synonym: "5'-AMP nucleotidase" NARROW [EC:3.1.3.5] synonym: "5'-AMPase" NARROW [EC:3.1.3.5] synonym: "5'-mononucleotidase activity" EXACT [EC:3.1.3.5] synonym: "5'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.5] synonym: "adenosine 5'-phosphatase" NARROW [EC:3.1.3.5] synonym: "adenosine monophosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphatase" NARROW [EC:3.1.3.5] synonym: "AMP phosphohydrolase" NARROW [EC:3.1.3.5] synonym: "AMPase" NARROW [EC:3.1.3.5] synonym: "snake venom 5'-nucleotidase" NARROW [EC:3.1.3.5] synonym: "thimidine monophosphate nucleotidase" NARROW [EC:3.1.3.5] synonym: "UMPase" NARROW [EC:3.1.3.5] synonym: "uridine 5'-nucleotidase" NARROW [EC:3.1.3.5] xref: EC:3.1.3.5 xref: MetaCyc:5-NUCLEOTID-RXN xref: Reactome:23614 "5'-nucleotidase activity" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008254 name: 3'-nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: a 3'-ribonucleotide + H2O = a ribonucleoside + phosphate." [EC:3.1.3.6] synonym: "3' nucleotidase activity" EXACT [] synonym: "3'-mononucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-phosphatase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotidase activity" EXACT [EC:3.1.3.6] synonym: "3'-ribonucleotide phosphohydrolase activity" EXACT [EC:3.1.3.6] xref: EC:3.1.3.6 xref: MetaCyc:3-NUCLEOTID-RXN is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008255 name: ecdysis-triggering hormone activity namespace: molecular_function def: "The action characteristic of ecdysis-triggering hormone, a peptide hormone that, upon receptor binding, initiates pre-ecdysis and ecdysis (i.e. cuticle shedding) through direct action on the central nervous system." [GOC:mah, PMID:9020043] is_a: GO:0005184 ! neuropeptide hormone activity [Term] id: GO:0008256 name: protein histidine pros-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(pi)-phospho-L-histidine." [EC:2.7.13.1] subset: gosubset_prok synonym: "ATP:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "ATP:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.13.1] synonym: "HK2" RELATED [EC:2.7.13.1] synonym: "protein-histidine pros-kinase activity" EXACT [EC:2.7.13.1] xref: EC:2.7.13.1 xref: MetaCyc:2.7.13.1-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008257 name: protein histidine tele-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + protein L-histidine = ADP + protein N(tau)-phospho-L-histidine." [EC:2.7.13.2] synonym: "ATP:protein-L-histidine N-tele-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "ATP:protein-L-histidine Ntau-phosphotransferase activity" EXACT [EC:2.7.13.2] synonym: "HK3" RELATED [EC:2.7.13.2] synonym: "protein-histidine tele-kinase activity" EXACT [EC:2.7.13.2] xref: EC:2.7.13.2 xref: MetaCyc:2.7.13.2-RXN is_a: GO:0004673 ! protein histidine kinase activity [Term] id: GO:0008258 name: head involution namespace: biological_process def: "Movement of the anterior ectoderm to the interior of the embryo." [ISBN:08795694238] is_a: GO:0048598 ! embryonic morphogenesis relationship: part_of GO:0001700 ! embryonic development via the syncytial blastoderm [Term] id: GO:0008259 name: transforming growth factor beta ligand binding to type I receptor namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a function. synonym: "TGF-beta ligand binding to type I receptor" EXACT [] synonym: "TGFbeta ligand binding to type I receptor" EXACT [] is_obsolete: true consider: GO:0005025 consider: GO:0005160 consider: GO:0050431 [Term] id: GO:0008260 name: 3-oxoacid CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + a 3-oxo acid = succinate + a 3-oxo-acyl-CoA." [EC:2.8.3.5] subset: gosubset_prok synonym: "3-ketoacid CoA-transferase activity" EXACT [EC:2.8.3.5] synonym: "3-ketoacid coenzyme A transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxo-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid CoA dehydrogenase activity" EXACT [EC:2.8.3.5] synonym: "3-oxoacid coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetate succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "acetoacetyl coenzyme A-succinic thiophorase activity" EXACT [EC:2.8.3.5] synonym: "succinyl coenzyme A-acetoacetyl coenzyme A-transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-ketoacid-CoA transferase activity" EXACT [EC:2.8.3.5] synonym: "succinyl-CoA:3-oxo-acid CoA-transferase activity" EXACT [EC:2.8.3.5] xref: EC:2.8.3.5 xref: MetaCyc:3-OXOACID-COA-TRANSFERASE-RXN xref: Reactome:23643 "3-oxoacid CoA-transferase activity" is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008261 name: allatostatin receptor activity namespace: molecular_function def: "Combining with allatostatin to initiate a change in cell activity." [GOC:ai] is_a: GO:0008528 ! peptide receptor activity, G-protein coupled [Term] id: GO:0008262 name: importin-alpha export receptor activity namespace: molecular_function def: "Interacting selectively and non-covalently with importin-alpha to mediate its transfer through the nuclear pore to the cytoplasm." [GOC:mah, GOC:vw, PMID:12486120] synonym: "importin-alpha binding" RELATED [] is_a: GO:0005049 ! nuclear export signal receptor activity is_a: GO:0008565 ! protein transporter activity [Term] id: GO:0008263 name: pyrimidine-specific mismatch base pair DNA N-glycosylase activity namespace: molecular_function def: "Catalysis of the removal of mismatched pyrimidine bases in DNA. Enzymes with this activity recognize and remove pyrimidines present in mismatches by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apyrimidinic (AP) site." [GOC:elh, PMID:9224623] synonym: "G/T-mismatch-specific thymine-DNA glycosylase activity" EXACT [] is_a: GO:0000700 ! mismatch base pair DNA N-glycosylase activity [Term] id: GO:0008265 name: Mo-molybdopterin cofactor sulfurase activity namespace: molecular_function def: "Catalysis of the sulfurylation of the desulfo form of molybdenum cofactor (MoCo), a cofactor required for the activity of some enzymes, such as aldehyde oxidase." [GOC:mah, PMID:11549764] synonym: "Mo-molybdopterin cofactor sulphurase activity" EXACT [] synonym: "molybdopterin cofactor sulfurase activity" EXACT [] synonym: "molybdopterin synthase sulfurylase activity" EXACT [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008266 name: poly(U) RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with a sequence of uracil residues in an RNA molecule." [GOC:mah] synonym: "poly(U) binding" EXACT [GOC:mah] is_a: GO:0008187 ! poly-pyrimidine tract binding [Term] id: GO:0008267 name: poly-glutamine tract binding namespace: molecular_function def: "Interacting selectively and non-covalently with a polyglutamine tract, i.e. a series of consecutive glutamine residues, in a protein." [GOC:mah] is_a: GO:0005515 ! protein binding [Term] id: GO:0008268 name: receptor signaling protein tyrosine kinase signaling protein activity namespace: molecular_function synonym: "receptor signalling protein tyrosine kinase signalling protein activity" EXACT [] is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0008269 name: JAK pathway signal transduction adaptor activity namespace: molecular_function def: "The binding activity of a molecule that brings together a molecule of the JAK signal transduction pathway and one or more other molecules of the pathway, permitting them to function in a coordinated way." [GOC:mtg_MIT_16mar07] is_a: GO:0008268 ! receptor signaling protein tyrosine kinase signaling protein activity is_a: GO:0060090 ! molecular adaptor activity [Term] id: GO:0008270 name: zinc ion binding namespace: molecular_function def: "Interacting selectively and non-covalently with zinc (Zn) ions." [GOC:ai] subset: gosubset_prok synonym: "zinc binding" EXACT [] is_a: GO:0046914 ! transition metal ion binding [Term] id: GO:0008271 name: secondary active sulfate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the secondary active transfer of sulfate from one side of the membrane to the other. Secondary active transport is catalysis of the transfer of a solute from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] subset: gosubset_prok synonym: "secondary active sulphate transmembrane transporter activity" EXACT [] synonym: "sulfate porter activity" RELATED [] synonym: "sulphate porter activity" EXACT [] is_a: GO:0015116 ! sulfate transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008272 name: sulfate transport namespace: biological_process alt_id: GO:0006870 def: "The directed movement of sulfate into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:krc] subset: gosubset_prok synonym: "sulphate transport" EXACT [] is_a: GO:0015698 ! inorganic anion transport [Term] id: GO:0008273 name: calcium, potassium:sodium antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + K+(in) + Na+(out) = Ca2+(out) + K+(out) + Na+(in)." [TC:2.A.19.4.1] synonym: "potassium-dependent sodium/calcium exchanger" RELATED [] xref: Reactome:23689 "calcium, potassium:sodium antiporter activity" is_a: GO:0015368 ! calcium:cation antiporter activity [Term] id: GO:0008274 name: gamma-tubulin ring complex namespace: cellular_component def: "A multiprotein complex composed of gamma-tubulin and other non-tubulin proteins that forms a flexible open ring structure thought to be the unit of nucleation at the minus end of a microtubule." [GOC:clt, PMID:12134075] synonym: "gammaTuRC" EXACT [] is_a: GO:0000931 ! gamma-tubulin large complex [Term] id: GO:0008275 name: gamma-tubulin small complex namespace: cellular_component def: "A complex usually comprising two gamma-tubulin molecules and two conserved non-tubulin proteins. Some gamma-tubulin small complexes are thought to be the repeating unit making up the core of the gamma-tubulin ring complex." [PMID:11297925, PMID:12134075] synonym: "gammaTuSC" EXACT [] is_a: GO:0000930 ! gamma-tubulin complex [Term] id: GO:0008276 name: protein methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group (CH3-) to a protein." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity relationship: part_of GO:0006479 ! protein amino acid methylation [Term] id: GO:0008277 name: regulation of G-protein coupled receptor protein signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of G-protein coupled receptor protein signaling pathway activity." [GOC:go_curators] synonym: "regulation of G protein coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signaling pathway" EXACT [] synonym: "regulation of G-protein-coupled receptor protein signalling pathway" EXACT [] synonym: "regulation of GPCR protein signaling pathway" EXACT [] synonym: "regulation of GPCR protein signalling pathway" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway relationship: regulates GO:0007186 ! G-protein coupled receptor protein signaling pathway [Term] id: GO:0008278 name: cohesin complex namespace: cellular_component alt_id: GO:0008279 def: "A protein complex required for sister chromatid cohesion in eukaryotes." [PMID:9887095] subset: goslim_pir synonym: "14S cohesin" NARROW [] synonym: "SMC complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part [Term] id: GO:0008280 name: cohesin core heterodimer namespace: cellular_component def: "The core heterodimer of a cohesin complex; a structure required for sister chromatid cohesion in eukaryotes." [GOC:jl] synonym: "9S cohesin" NARROW [] synonym: "Smc1-Smc3 complex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044427 ! chromosomal part intersection_of: GO:0043234 ! protein complex intersection_of: part_of GO:0008278 ! cohesin complex relationship: part_of GO:0008278 ! cohesin complex [Term] id: GO:0008281 name: sulfonylurea receptor activity namespace: molecular_function def: "Combining with sulfonylurea to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function term 'potassium channel activity ; GO:0005267'. synonym: "sulphonylurea receptor activity" EXACT [] is_a: GO:0004888 ! transmembrane receptor activity [Term] id: GO:0008282 name: ATP-sensitive potassium channel complex namespace: cellular_component def: "A protein complex that comprises four pore-forming (Kir6.x) and four regulatory sulphonylurea receptor (SURx) subunits and forms a transmembrane channel through which ions may pass. The opening and closing of the channel is regulated by ATP: binding of ATP to the Kir6.2 subunit inhibits channel activity, whereas binding of Mg2+-complexed ATP or ADP to the SUR1 subunit stimulates channel activity." [PMID:16308567, PMID:16956886] is_a: GO:0034702 ! ion channel complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008283 name: cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a cell population." [GOC:mah, GOC:mb] comment: This term was moved out from being a child of 'cellular process' because it is a cell population-level process, and cellular processes are restricted to those processes that involve individual cells. subset: goslim_generic subset: goslim_pir subset: gosubset_prok is_a: GO:0008150 ! biological_process [Term] id: GO:0008284 name: positive regulation of cell proliferation namespace: biological_process def: "Any process that activates or increases the rate or extent of cell proliferation." [GOC:go_curators] subset: gosubset_prok synonym: "activation of cell proliferation" NARROW [] synonym: "stimulation of cell proliferation" NARROW [] synonym: "up regulation of cell proliferation" EXACT [] synonym: "up-regulation of cell proliferation" EXACT [] synonym: "upregulation of cell proliferation" EXACT [] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048522 ! positive regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008283 ! cell proliferation relationship: positively_regulates GO:0008283 ! cell proliferation [Term] id: GO:0008285 name: negative regulation of cell proliferation namespace: biological_process def: "Any process that stops, prevents or reduces the rate or extent of cell proliferation." [GOC:go_curators] synonym: "down regulation of cell proliferation" EXACT [] synonym: "down-regulation of cell proliferation" EXACT [] synonym: "downregulation of cell proliferation" EXACT [] synonym: "inhibition of cell proliferation" NARROW [] is_a: GO:0042127 ! regulation of cell proliferation is_a: GO:0048523 ! negative regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008283 ! cell proliferation relationship: negatively_regulates GO:0008283 ! cell proliferation [Term] id: GO:0008286 name: insulin receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the insulin receptor binding to insulin." [GOC:ceb] synonym: "daf-2 receptor signaling pathway" NARROW [] synonym: "insulin receptor signalling pathway" EXACT [] xref: Reactome:562697 "Signaling by Insulin receptor" xref: Reactome:588318 "Signaling by Insulin receptor" xref: Reactome:609062 "Signaling by Insulin receptor" xref: Reactome:633755 "Signaling by Insulin receptor" xref: Reactome:645364 "Signaling by Insulin receptor" xref: Reactome:655732 "Signaling by Insulin receptor" xref: Reactome:661013 "Signaling by Insulin receptor" xref: Reactome:666791 "Signaling by Insulin receptor" xref: Reactome:672902 "Signaling by Insulin receptor" xref: Reactome:678616 "Signaling by Insulin receptor" xref: Reactome:683597 "Signaling by Insulin receptor" xref: Reactome:689772 "Signaling by Insulin receptor" xref: Reactome:701548 "Signaling by Insulin receptor" xref: Reactome:716132 "Signaling by Insulin receptor" xref: Reactome:720902 "Signaling by Insulin receptor" xref: Reactome:728033 "Signaling by Insulin receptor" xref: Reactome:731064 "Signaling by Insulin receptor" xref: Reactome:74752 "Signaling by Insulin receptor" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway is_a: GO:0032869 ! cellular response to insulin stimulus [Term] id: GO:0008287 name: protein serine/threonine phosphatase complex namespace: cellular_component def: "A complex, normally consisting of a catalytic and a regulatory subunit, which catalyzes the removal of a phosphate group from a serine or threonine residue of a protein." [GOC:bf] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0008288 name: boss receptor activity namespace: molecular_function def: "Combining with the protein bride of sevenless (boss) to initiate a change in cell activity." [GOC:jl] synonym: "sevenless receptor activity" RELATED [] is_a: GO:0004714 ! transmembrane receptor protein tyrosine kinase activity [Term] id: GO:0008289 name: lipid binding namespace: molecular_function def: "Interacting selectively and non-covalently with a lipid." [GOC:ai] subset: goslim_candida subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: goslim_yeast subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008290 name: F-actin capping protein complex namespace: cellular_component def: "A heterodimer consisting of alpha and beta subunits that binds to and caps the barbed ends of actin filaments, thereby regulating the polymerization of actin monomers but not severing actin filaments." [GOC:go_curators, ISBN:0198599560] subset: goslim_pir is_a: GO:0043234 ! protein complex is_a: GO:0044430 ! cytoskeletal part relationship: part_of GO:0015629 ! actin cytoskeleton [Term] id: GO:0008291 name: acetylcholine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving acetylcholine, the acetic acid ester of the organic base choline. Acetylcholine is a major neurotransmitter and neuromodulator both in the central and peripheral nervous systems. It also acts as a paracrine signal in various non-neural tissues." [GOC:jl, GOC:nln, ISBN:0192800752] synonym: "acetylcholine metabolism" EXACT [] is_a: GO:0042133 ! neurotransmitter metabolic process is_a: GO:0042439 ! ethanolamine and derivative metabolic process [Term] id: GO:0008292 name: acetylcholine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of acetylcholine, the acetic acid ester of the organic base choline." [GOC:jl, ISBN:0192800752] synonym: "acetylcholine anabolism" EXACT [] synonym: "acetylcholine biosynthesis" EXACT [] synonym: "acetylcholine formation" EXACT [] synonym: "acetylcholine synthesis" EXACT [] is_a: GO:0008291 ! acetylcholine metabolic process is_a: GO:0042136 ! neurotransmitter biosynthetic process is_a: GO:0042401 ! cellular biogenic amine biosynthetic process [Term] id: GO:0008293 name: torso signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of the torso transmembrane receptor tyrosine kinase binding to its physiological ligand." [GOC:go_curators] synonym: "torso signalling pathway" EXACT [] is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008294 name: calcium- and calmodulin-responsive adenylate cyclase activity namespace: molecular_function def: "Catalysis of the reaction: ATP = 3',5'-cyclic AMP + diphosphate, stimulated by calcium-bound calmodulin." [EC:4.6.1.1, GOC:mah] synonym: "calcium- and calmodulin-responsive adenylyl cyclase activity" EXACT [] synonym: "calcium/calmodulin-responsive adenylate cyclase activity" EXACT [] xref: Reactome:23748 "calcium- and calmodulin-responsive adenylate cyclase activity" is_a: GO:0004016 ! adenylate cyclase activity [Term] id: GO:0008295 name: spermidine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of spermidine, N-(3-aminopropyl)-1,4-diaminobutane." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "spermidine anabolism" EXACT [] synonym: "spermidine biosynthesis" EXACT [] synonym: "spermidine formation" EXACT [] synonym: "spermidine synthesis" EXACT [] xref: MetaCyc:BSUBPOLYAMSYN-PWY xref: MetaCyc:POLYAMINSYN3-PWY is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0008216 ! spermidine metabolic process [Term] id: GO:0008296 name: 3'-5'-exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a DNA molecule." [GOC:mah] synonym: "3'-5' exodeoxyribonuclease activity" EXACT [] is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008297 name: single-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a single-stranded DNA molecule." [GOC:mah] subset: gosubset_prok synonym: "ssDNA-specific exodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008298 name: intracellular mRNA localization namespace: biological_process def: "Any process by which mRNA is transported to, or maintained in, a specific location within the cell." [GOC:ai] synonym: "establishment and maintenance of intracellular RNA localization" EXACT [] synonym: "intracellular mRNA positioning" NARROW [] synonym: "mRNA localization, intracellular" EXACT [] synonym: "mRNA positioning, intracellular" NARROW [] is_a: GO:0006403 ! RNA localization is_a: GO:0070727 ! cellular macromolecule localization [Term] id: GO:0008299 name: isoprenoid biosynthetic process namespace: biological_process alt_id: GO:0009241 def: "The chemical reactions and pathways resulting in the formation of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isoprenoid anabolism" EXACT [] synonym: "isoprenoid biosynthesis" EXACT [] synonym: "isoprenoid formation" EXACT [] synonym: "isoprenoid synthesis" EXACT [] synonym: "polyisoprenoid anabolism" NARROW [] synonym: "polyisoprenoid biosynthesis" NARROW [] synonym: "polyisoprenoid biosynthetic process" NARROW [] synonym: "polyisoprenoid formation" NARROW [] synonym: "polyisoprenoid synthesis" NARROW [] synonym: "polyterpene biosynthesis" NARROW [] synonym: "polyterpene biosynthetic process" NARROW [] xref: MetaCyc:POLYISOPRENSYN-PWY is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008300 name: isoprenoid catabolic process namespace: biological_process alt_id: GO:0016097 def: "The chemical reactions and pathways resulting in the breakdown of any isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "isoprenoid breakdown" EXACT [] synonym: "isoprenoid catabolism" EXACT [] synonym: "isoprenoid degradation" EXACT [] synonym: "polyisoprenoid breakdown" NARROW [] synonym: "polyisoprenoid catabolic process" NARROW [] synonym: "polyisoprenoid catabolism" NARROW [] synonym: "polyisoprenoid degradation" NARROW [] synonym: "polyterpene catabolic process" NARROW [] synonym: "polyterpene catabolism" NARROW [] is_a: GO:0006720 ! isoprenoid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0008301 name: DNA bending activity namespace: molecular_function def: "An activity that results in binding to DNA and distorting the original structure of DNA, typically a straight helix, into a bend, or increasing the bend if the original structure was intrinsically bent due to its sequence." [GOC:krc, PMID:10710711, PMID:19037758] subset: gosubset_prok is_a: GO:0003677 ! DNA binding [Term] id: GO:0008302 name: female germline ring canal formation, actin assembly namespace: biological_process def: "Recruitment and organization of actin filaments in female germline ring canals." [ISBN:0879694238] synonym: "nurse cell ring canal formation, actin assembly" NARROW [] synonym: "ovarian ring canal formation, actin assembly" NARROW [] synonym: "ring canal formation, actin assembly" BROAD [] is_a: GO:0007015 ! actin filament organization is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007301 ! female germline ring canal formation [Term] id: GO:0008303 name: caspase complex namespace: cellular_component def: "A protein complex that is located in the cytosol and acts as a cysteine-type endopeptidase are involved in apoptosis; the peptidase activity has specificity for the hydrolysis of aspartyl bonds." [GOC:mah, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008304 name: eukaryotic translation initiation factor 4 complex namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific terms were created. synonym: "eIF-4" EXACT [] is_obsolete: true replaced_by: GO:0016281 [Term] id: GO:0008305 name: integrin complex namespace: cellular_component def: "A protein complex that is composed of one alpha subunit and one beta subunit, both of which are members of the integrin superfamily of cell adhesion receptors; the complex spans the plasma membrane and binds to extracellular matrix ligands, cell-surface ligands, and soluble ligands." [PMID:17543136] subset: gosubset_prok synonym: "laminin receptor protein" RELATED [] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008306 name: associative learning namespace: biological_process def: "Learning by associating a stimulus (the cause) with a particular outcome (the effect)." [ISBN:0582227089] synonym: "classical conditioning" EXACT [] synonym: "conditional learning" EXACT [] synonym: "conditional response" EXACT [] synonym: "Pavlovian conditioning" EXACT [] xref: Wikipedia:Learning#Associative_learning is_a: GO:0007612 ! learning [Term] id: GO:0008307 name: structural constituent of muscle namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of a muscle fiber." [GOC:mah] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008308 name: voltage-gated anion channel activity namespace: molecular_function alt_id: GO:0022844 def: "Catalysis of the transmembrane transfer of an anion by a voltage-gated channel. An anion is a negatively charged ion." [GOC:mtg_transport, ISBN:0815340729] synonym: "voltage-dependent ion-selective channel activity" RELATED [] synonym: "voltage-gated ion-selective channel activity" RELATED [] is_a: GO:0005244 ! voltage-gated ion channel activity is_a: GO:0005253 ! anion channel activity relationship: part_of GO:0044070 ! regulation of anion transport [Term] id: GO:0008309 name: double-stranded DNA specific exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a double-stranded DNA molecule." [GOC:mah] is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008310 name: single-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a single-stranded DNA molecule." [GOC:mah] synonym: "ssDNA-specific 3'-5' exodeoxyribonuclease activity" EXACT [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008297 ! single-stranded DNA specific exodeoxyribonuclease activity [Term] id: GO:0008311 name: double-stranded DNA specific 3'-5' exodeoxyribonuclease activity namespace: molecular_function def: "Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of a double-stranded DNA molecule." [GOC:mah] is_a: GO:0008296 ! 3'-5'-exodeoxyribonuclease activity is_a: GO:0008309 ! double-stranded DNA specific exodeoxyribonuclease activity [Term] id: GO:0008312 name: 7S RNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with 7S RNA, the RNA component of the signal recognition particle (SRP)." [GOC:jl, PMID:6181418] subset: gosubset_prok is_a: GO:0003723 ! RNA binding [Term] id: GO:0008313 name: gurken receptor activity namespace: molecular_function def: "Combining with the ligand Gurken to initiate a change in cell activity." [GOC:bf] is_a: GO:0005006 ! epidermal growth factor receptor activity [Term] id: GO:0008314 name: gurken receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of an epidermal growth factor receptor binding to the ligand Gurken." [GOC:bf] synonym: "gurken receptor signalling pathway" EXACT [] is_a: GO:0007173 ! epidermal growth factor receptor signaling pathway [Term] id: GO:0008315 name: meiotic G2/MI transition namespace: biological_process def: "The cell cycle process whereby a cell progresses from meiotic prophase to metaphase I." [PMID:15088480] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007127 ! meiosis I [Term] id: GO:0008316 name: structural constituent of vitelline membrane namespace: molecular_function def: "The action of a molecule that contributes to the structural integrity of the vitelline membrane of an egg. An example of this is found in Drosophila melanogaster." [GOC:mah, GOC:sensu] is_a: GO:0005198 ! structural molecule activity [Term] id: GO:0008317 name: gurken receptor binding namespace: molecular_function def: "Interacting selectively and non-covalently with the gurken growth factor receptor." [GOC:ai] synonym: "gurken receptor ligand" NARROW [] is_a: GO:0005154 ! epidermal growth factor receptor binding [Term] id: GO:0008318 name: protein prenyltransferase activity namespace: molecular_function alt_id: GO:0008244 def: "Catalysis of the covalent addition of an isoprenoid group such as a farnesyl or geranylgeranyl group via thioether linkages to a cysteine residue in a protein." [GOC:mah] xref: EC:2.5.1.- is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008319 name: prenyl protein specific endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. xref: EC:3.4.24.- is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008320 name: protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a protein from one side of a membrane to the other." [GOC:jl] subset: gosubset_prok is_a: GO:0008565 ! protein transporter activity is_a: GO:0022884 ! macromolecule transmembrane transporter activity [Term] id: GO:0008321 name: Ral guanyl-nucleotide exchange factor activity namespace: molecular_function def: "Stimulates the exchange of guanyl nucleotides associated with a GTPase of the Ral family. Under normal cellular physiological conditions, the concentration of GTP is higher than that of GDP, favoring the replacement of GDP by GTP in association with the GTPase." [GOC:mah] xref: Reactome:24053 "Ral guanyl-nucleotide exchange factor activity" is_a: GO:0005088 ! Ras guanyl-nucleotide exchange factor activity [Term] id: GO:0008322 name: Pro-X carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Pro-Xaa bond to release a C-terminal amino acid." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008324 name: cation transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of cation from one side of the membrane to the other." [GOC:df, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "transmembrane cation transporter activity" EXACT [] is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0006812 ! cation transport [Term] id: GO:0008327 name: methyl-CpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/guanine dinucleotide." [GOC:jl, PMID:11746232] is_a: GO:0000166 ! nucleotide binding is_a: GO:0043565 ! sequence-specific DNA binding [Term] id: GO:0008328 name: ionotropic glutamate receptor complex namespace: cellular_component def: "A multimeric assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand-gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex." [http://www.bris.ac.uk/Depts/Synaptic/info/glutamate.html] is_a: GO:0043235 ! receptor complex is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0005887 ! integral to plasma membrane [Term] id: GO:0008329 name: pattern recognition receptor activity namespace: molecular_function def: "Combining with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity. Such molecular patterns are sometimes associated with potential pathogens." [PMID:12507420, PMID:12925128, PMID:14523544] comment: Note that this term and its child terms are intended for gene products which are directly coupled to a signal transduction pathway; gene products which recognize polymeric structures such as polysaccharides or peptidoglycans in extracellular space, but are not directly coupled to signal transduction pathway, should use the term 'pattern binding ; GO:0001871' or its child terms. Note that many gene products that are called pattern recognition receptors in the literature have a broad range of potential ligands and also can be annotated to 'scavenger receptor activity ; GO:0005044'. synonym: "macrophage receptor activity" RELATED [] is_a: GO:0004872 ! receptor activity relationship: part_of GO:0002221 ! pattern recognition receptor signaling pathway [Term] id: GO:0008330 name: protein tyrosine/threonine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: protein threonine/tyrosine phosphate + H2O = protein threonine/tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- is_a: GO:0004721 ! phosphoprotein phosphatase activity [Term] id: GO:0008331 name: high voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a high voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "high voltage gated calcium channel activity" EXACT [] synonym: "high voltage-dependent calcium channel activity" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008332 name: low voltage-gated calcium channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of a calcium ion by a low voltage-gated channel." [GOC:mtg_transport, ISBN:0815340729] synonym: "low voltage gated calcium channel activity" EXACT [] synonym: "low voltage-dependent calcium channel activity" EXACT [] synonym: "T-type channel" EXACT [] is_a: GO:0005245 ! voltage-gated calcium channel activity [Term] id: GO:0008333 name: endosome to lysosome transport namespace: biological_process def: "The directed movement of substances from endosomes to lysosomes." [GOC:ai, ISBN:0716731363] is_a: GO:0007041 ! lysosomal transport is_a: GO:0016197 ! endosome transport [Term] id: GO:0008334 name: histone mRNA metabolic process namespace: biological_process def: "The chemical reactions and pathways involving an mRNA encoding a histone." [GOC:mah] synonym: "histone mRNA metabolism" EXACT [] is_a: GO:0016071 ! mRNA metabolic process [Term] id: GO:0008335 name: female germline ring canal stabilization namespace: biological_process def: "Maintenance of the structural integrity of the ring canals connecting the female germline cyst." [GOC:curators] synonym: "nurse cell ring canal stabilization" NARROW [] synonym: "ovarian ring canal stabilization" NARROW [] is_a: GO:0031032 ! actomyosin structure organization is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007300 ! ovarian nurse cell to oocyte transport [Term] id: GO:0008336 name: gamma-butyrobetaine dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 4-trimethylammoniobutanoate + 2-oxoglutarate + O2 = 3-hydroxy-4-trimethylammoniobutanoate + succinate + CO2." [EC:1.14.11.1] subset: gosubset_prok synonym: "4-trimethylammoniobutanoate,2-oxoglutarate:oxygen oxidoreductase (3-hydroxylating)" EXACT [EC:1.14.11.1] synonym: "alpha-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "g-butyrobetaine dioxygenase activity" EXACT [] synonym: "gamma-BBH activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine hydroxylase activity" EXACT [EC:1.14.11.1] synonym: "gamma-butyrobetaine,2-oxoglutarate dioxygenase activity" EXACT [] xref: EC:1.14.11.1 xref: MetaCyc:1.14.11.1-RXN xref: Reactome:24086 "gamma-butyrobetaine dioxygenase activity" is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0008337 name: selectin namespace: molecular_function def: "OBSOLETE. A class of cell adhesion molecules that bind to carbohydrate via a lectin-like domain; integral membrane glycoproteins." [ISBN:0124325653] comment: This term was made obsolete because it describes a class of gene products. is_obsolete: true consider: GO:0005102 consider: GO:0007155 consider: GO:0016021 consider: GO:0030246 consider: GO:0050839 [Term] id: GO:0008338 name: MAP kinase 1 activity namespace: molecular_function synonym: "ERK1" EXACT [] xref: EC:2.7.11.- xref: MetaCyc:2.7.11.24-RXN is_a: GO:0004707 ! MAP kinase activity [Term] id: GO:0008339 name: MP kinase activity namespace: molecular_function synonym: "Mpk2" NARROW [] synonym: "p38" NARROW [] synonym: "SAPK2" NARROW [] xref: EC:2.7.11.- is_a: GO:0016909 ! SAP kinase activity [Term] id: GO:0008340 name: determination of adult lifespan namespace: biological_process def: "The control of viability and duration in the adult phase of the life-cycle." [GOC:ems] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0010259 ! multicellular organismal aging [Term] id: GO:0008341 name: response to cocaine (sensu Insecta) namespace: biological_process def: "OBSOLETE. A change in state or activity of a mature individual as the result of a cocaine stimulus. As in, but not restricted to, the true insects (Insecta, ncbi_taxonomy_id:50557)." [GOC:go_curators, GOC:jid] comment: This term was made obsolete because there is no clear difference between the sensu Insecta term and the generic term. is_obsolete: true consider: GO:0048148 [Term] id: GO:0008342 name: larval feeding behavior (sensu Insecta) namespace: biological_process def: "OBSOLETE. Feeding behavior in an insect larva." [GOC:jid, GOC:mah] comment: This term was made obsolete because there is no clear difference between the sensu Drosophila term and the generic term. is_obsolete: true replaced_by: GO:0030536 [Term] id: GO:0008343 name: adult feeding behavior namespace: biological_process def: "Feeding behavior in a fully developed and mature organism." [GOC:mah] comment: See also the biological process term 'feeding behavior ; GO:0007631'. synonym: "adult feeding behaviour" EXACT [] is_a: GO:0007631 ! feeding behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008344 name: adult locomotory behavior namespace: biological_process def: "Locomotory behavior in a fully developed and mature organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "adult locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030534 ! adult behavior [Term] id: GO:0008345 name: larval locomotory behavior namespace: biological_process def: "Locomotory behavior in a larval (immature) organism." [GOC:ai] comment: See also the biological process term 'locomotory behavior ; GO:0007626'. synonym: "larval locomotory behaviour" EXACT [] is_a: GO:0007626 ! locomotory behavior is_a: GO:0030537 ! larval behavior [Term] id: GO:0008346 name: larval walking behavior namespace: biological_process def: "The actions or reactions of a larval organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg." [GOC:go_curators] synonym: "larval walking behaviour" EXACT [] is_a: GO:0008345 ! larval locomotory behavior [Term] id: GO:0008347 name: glial cell migration namespace: biological_process alt_id: GO:0043359 def: "The orderly movement of a glial cell, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system." [GOC:jl, GOC:mtg_sensu] synonym: "glia cell migration" EXACT [] is_a: GO:0016477 ! cell migration relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0008348 name: negative regulation of antimicrobial humoral response namespace: biological_process alt_id: GO:0042154 alt_id: GO:0042155 def: "Any process that stops, prevents, or reduces the frequency, rate, or extent of an antimicrobial humoral response." [GOC:go_curators] synonym: "attenuation of antimicrobial humoral response" EXACT [] synonym: "down regulation of antimicrobial humoral response" EXACT [] synonym: "down-regulation of antimicrobial humoral response" EXACT [] synonym: "downregulation of antimicrobial humoral response" EXACT [] synonym: "inhibition of antimicrobial humoral response" NARROW [] is_a: GO:0002759 ! regulation of antimicrobial humoral response is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0002921 ! negative regulation of humoral immune response is_a: GO:0043901 ! negative regulation of multi-organism process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019730 ! antimicrobial humoral response relationship: negatively_regulates GO:0019730 ! antimicrobial humoral response [Term] id: GO:0008349 name: MAP kinase kinase kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of serine and threonine residues in a mitogen-activated protein kinase kinase kinase (MAPKKK), resulting in activation of MAPKKK. MAPKKK signaling pathways relay, amplify and integrate signals from the plasma membrane to the nucleus in response to a diverse range of extracellular stimuli." [GOC:bf, PMID:11790549] synonym: "MAPKKKK" EXACT [] xref: EC:2.7.11.- is_a: GO:0004702 ! receptor signaling protein serine/threonine kinase activity [Term] id: GO:0008350 name: kinetochore motor activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it includes cellular component information. is_obsolete: true consider: GO:0000776 consider: GO:0003777 [Term] id: GO:0008351 name: microtubule severing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a biological process. is_obsolete: true replaced_by: GO:0008017 replaced_by: GO:0051013 [Term] id: GO:0008352 name: katanin complex namespace: cellular_component def: "A complex possessing an activity that couples ATP hydrolysis to the severing of microtubules; usually a heterodimer comprising a catalytic subunit (often 60kDa) and a regulatory subunit (often 80 kDa)." [PMID:10910766] comment: Consider also annotating to the molecular function term 'microtubule-severing ATPase activity ; GO:0008568'. is_a: GO:0005875 ! microtubule associated complex is_a: GO:0044450 ! microtubule organizing center part relationship: part_of GO:0005813 ! centrosome [Term] id: GO:0008353 name: RNA polymerase II carboxy-terminal domain kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (DNA-directed RNA polymerase II) = ADP + phospho-(DNA-directed RNA polymerase II); phosphorylation occurs on residues in the carboxy-terminal domain (CTD) repeats." [EC:2.7.11.23, GOC:mah] synonym: "[RNA-polymerase]-subunit kinase activity" BROAD [] synonym: "ATP:DNA-directed RNA polymerase phosphotransferase activity" BROAD [EC:2.7.11.23] synonym: "CTD kinase activity" EXACT [EC:2.7.11.23] synonym: "RNA polymerase subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "RNA-polymerase-subunit kinase activity" BROAD [EC:2.7.11.23] synonym: "STK9" RELATED [EC:2.7.11.23] xref: EC:2.7.11.23 xref: MetaCyc:RNA-POLYMERASE-SUBUNIT-KINASE-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008354 name: germ cell migration namespace: biological_process def: "The orderly movement of a cell specialized to produce haploid gametes through the embryo from its site of production to the place where the gonads will form." [GOC:bf, GOC:jl] synonym: "germ-cell migration" EXACT [] synonym: "primordial germ cell migration" RELATED [] is_a: GO:0016477 ! cell migration is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007276 ! gamete generation [Term] id: GO:0008355 name: olfactory learning namespace: biological_process def: "Any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue." [ISBN:0582227089] is_a: GO:0008306 ! associative learning is_a: GO:0042048 ! olfactory behavior [Term] id: GO:0008356 name: asymmetric cell division namespace: biological_process def: "The asymmetric division of cells to produce two daughter cells with different developmental potentials. It is of fundamental significance for the generation of cell diversity." [PMID:11672519] synonym: "asymmetric cytokinesis" RELATED [] synonym: "asymmetrical cell division" EXACT [] synonym: "asymmetrical cytokinesis" RELATED [] xref: Wikipedia:Asymmetric_cell_division is_a: GO:0051301 ! cell division [Term] id: GO:0008358 name: maternal determination of anterior/posterior axis, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by gradients of maternally-transcribed gene products; exemplified in insects by the morphogens, bicoid and nanos." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] is_a: GO:0008595 ! anterior/posterior axis specification, embryo [Term] id: GO:0008359 name: regulation of bicoid mRNA localization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the process by which bicoid mRNA is transported to, or maintained in, a specific location." [GOC:hb] is_a: GO:0045995 ! regulation of embryonic development is_a: GO:0060281 ! regulation of oocyte development is_a: GO:0060341 ! regulation of cellular localization intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045450 ! bicoid mRNA localization relationship: regulates GO:0045450 ! bicoid mRNA localization [Term] id: GO:0008360 name: regulation of cell shape namespace: biological_process alt_id: GO:0045788 alt_id: GO:0045789 def: "Any process that modulates the surface configuration of a cell." [GOC:dph, GOC:go_curators, GOC:tb] subset: gosubset_prok is_a: GO:0022604 ! regulation of cell morphogenesis is_a: GO:0065008 ! regulation of biological quality [Term] id: GO:0008361 name: regulation of cell size namespace: biological_process def: "Any process that modulates the size of a cell." [GOC:go_curators] subset: gosubset_prok synonym: "cell size control" EXACT [] is_a: GO:0032535 ! regulation of cellular component size [Term] id: GO:0008362 name: chitin-based embryonic cuticle biosynthetic process namespace: biological_process def: "Synthesis, including the chemical reactions and pathways resulting in the formation of chitin and other components, and deposition of a chitin-based embryonic cuticle by the underlying epidermal epithelium. This tough, waterproof cuticle layer is essential to provide structural integrity of the larval body. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, PMID:12019232] synonym: "embryonic cuticle anabolism" BROAD [] synonym: "embryonic cuticle biosynthetic process" BROAD [] synonym: "embryonic cuticle formation" BROAD [] synonym: "embryonic cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008363 name: larval chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based larval cuticle. The insect larval cuticle is a secretion from epidermal cells that is shed at each molt. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "larval cuticle anabolism" BROAD [] synonym: "larval cuticle biosynthetic process" BROAD [] synonym: "larval cuticle formation" BROAD [] synonym: "larval cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0002168 ! instar larval development [Term] id: GO:0008364 name: pupal chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of a chitin-based pupal cuticle. At the end of the prepupal period the insect is covered by the pupal cuticle which continues to be elaborated into the pupal period. An example of this is found in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "pupal cuticle anabolism" BROAD [] synonym: "pupal cuticle formation" BROAD [] synonym: "pupal cuticle synthesis" BROAD [] is_a: GO:0042337 ! cuticle development involved in chitin-based cuticle molting cycle relationship: part_of GO:0035209 ! pupal development [Term] id: GO:0008365 name: adult chitin-based cuticle development namespace: biological_process def: "Synthesis and deposition of the chitin-based cuticle of adults following the apolysis of the pupal cuticle. The adult insect cuticle contains cuticullin, a protein epicuticle and a lamellate procuticle. An example of this process is adult chitin-based cuticle development in Drosophila melanogaster." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] synonym: "adult chitin-based cuticle anabolism" EXACT [] synonym: "adult chitin-based cuticle biosynthetic process" EXACT [] synonym: "adult chitin-based cuticle formation" EXACT [] synonym: "adult chitin-based cuticle synthesis" EXACT [] synonym: "adult cuticle anabolism" BROAD [] synonym: "adult cuticle biosynthetic process" BROAD [] synonym: "adult cuticle formation" BROAD [] synonym: "adult cuticle synthesis" BROAD [] is_a: GO:0040003 ! chitin-based cuticle development [Term] id: GO:0008366 name: axon ensheathment namespace: biological_process alt_id: GO:0042553 def: "Any process by which the axon of a neuron is insulated, and that insulation maintained, thereby preventing dispersion of the electrical signal." [GOC:jl, ISBN:0878932437] synonym: "cellular axon ensheathment" EXACT [] synonym: "cellular nerve ensheathment" RELATED [] synonym: "nerve ensheathment" RELATED [] is_a: GO:0007272 ! ensheathment of neurons [Term] id: GO:0008369 name: obsolete molecular function namespace: molecular_function def: "OBSOLETE. These are terms that have been removed from the active function ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008370 name: obsolete cellular component namespace: cellular_component def: "OBSOLETE. These are terms that have been removed from the active component ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008371 name: obsolete biological process namespace: biological_process def: "OBSOLETE. These are terms that have been removed from the active process ontology." [GOC:go_curators] comment: This term was made obsolete because it is unnecessary in the OBO flat file format. is_obsolete: true [Term] id: GO:0008373 name: sialyltransferase activity namespace: molecular_function def: "Catalysis of the formation of sialylglycoconjugates via transfer of the sialic acid group from CMP to one of several glycoconjugate acceptors." [GOC:jl, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: EC:2.4.99.- xref: MetaCyc:2.4.99.10-RXN is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008374 name: O-acyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an acyl group to an oxygen atom on the acceptor molecule." [GOC:ai] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:1150 "O-acyltransferase activity" is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008375 name: acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylglucosaminyl residue from UDP-N-acetyl-glucosamine to a sugar." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "GlcNAc transferase activity" EXACT [] xref: EC:2.4.1.- xref: MetaCyc:2.4.1.223-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008376 name: acetylgalactosaminyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an oligosaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "GalNAc transferase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008377 name: light-induced release of internally sequestered calcium ion namespace: biological_process def: "The process by which the detection of light triggers the release of internally sequestered calcium ions." [GOC:ai] synonym: "light-induced release of calcium from internal store" EXACT [] synonym: "light-induced release of internally sequestered calcium ion (Ca2+)" EXACT [] synonym: "light-induced release of internally stored calcium ion (Ca2+)" EXACT [] is_a: GO:0051283 ! negative regulation of sequestering of calcium ion relationship: part_of GO:0009586 ! rhodopsin mediated phototransduction [Term] id: GO:0008378 name: galactosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a galactosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.4.1.- xref: MetaCyc:2.4.1.151-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008379 name: thioredoxin peroxidase activity namespace: molecular_function alt_id: GO:0009031 def: "Catalysis of the reaction: thioredoxin + H2O2 = thioredoxin disulfide + H2O." [MetaCyc:RXN0-267] subset: gosubset_prok synonym: "thiol peroxidase activity" EXACT [] synonym: "TPx activity" EXACT [] synonym: "TrxPx activity" EXACT [] xref: EC:1.11.1.- xref: MetaCyc:RXN0-267 is_a: GO:0004601 ! peroxidase activity is_a: GO:0051920 ! peroxiredoxin activity [Term] id: GO:0008380 name: RNA splicing namespace: biological_process alt_id: GO:0006395 def: "The process of removing sections of the primary RNA transcript to remove sequences not present in the mature form of the RNA and joining the remaining sections to form the mature form of the RNA." [GOC:krc, GOC:mah] subset: gosubset_prok synonym: "pre-mRNA splicing factor activity" RELATED [] xref: Reactome:562936 "mRNA Splicing" xref: Reactome:588557 "mRNA Splicing" xref: Reactome:609298 "mRNA Splicing" xref: Reactome:633988 "mRNA Splicing" xref: Reactome:645548 "mRNA Splicing" xref: Reactome:655888 "mRNA Splicing" xref: Reactome:666852 "mRNA Splicing" xref: Reactome:672967 "mRNA Splicing" xref: Reactome:678686 "mRNA Splicing" xref: Reactome:689853 "mRNA Splicing" xref: Reactome:701589 "mRNA Splicing" xref: Reactome:716173 "mRNA Splicing" xref: Reactome:720747 "mRNA Splicing" xref: Reactome:72172 "mRNA Splicing" xref: Reactome:728123 "mRNA Splicing" xref: Reactome:731008 "mRNA Splicing" xref: Wikipedia:RNA_splicing is_a: GO:0006396 ! RNA processing [Term] id: GO:0008381 name: mechanically-gated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a mechanical stress." [GOC:mtg_transport, ISBN:0815340729] is_a: GO:0005216 ! ion channel activity is_a: GO:0022833 ! mechanically gated channel activity [Term] id: GO:0008384 name: IkappaB kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + IkappaB protein = ADP + IkappaB phosphoprotein." [EC:2.7.11.10] comment: Note that phosphorylation of IkappaB targets it for proteasomal degradation and allows the nuclear translocation of kB. The kinase is composed of alpha, beta and gamma subunits, of which the latter does not have kinase activity but is presumed to play a regulatory role. synonym: "ATP:IkappaB protein phosphotransferase activity" EXACT [EC:2.7.11.10] synonym: "CHUK" RELATED [EC:2.7.11.10] synonym: "ikappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "IKBKA" RELATED [EC:2.7.11.10] synonym: "IKBKB" RELATED [EC:2.7.11.10] synonym: "IKK" RELATED [EC:2.7.11.10] synonym: "IKK-1" RELATED [EC:2.7.11.10] synonym: "IKK-2" RELATED [EC:2.7.11.10] synonym: "inhibitor of NF-kappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "inhibitor of NFkappaB kinase activity" EXACT [EC:2.7.11.10] synonym: "STK12" RELATED [EC:2.7.11.10] synonym: "TANK-binding kinase 1 activity" NARROW [EC:2.7.11.10] synonym: "TBK1" RELATED [EC:2.7.11.10] xref: EC:2.7.11.10 xref: MetaCyc:2.7.11.10-RXN is_a: GO:0004674 ! protein serine/threonine kinase activity [Term] id: GO:0008385 name: IkappaB kinase complex namespace: cellular_component def: "A protein serine/threonine kinase that phosphorylates IkappaB, thereby targeting this for proteasomal degradation and allowing the nuclear translocation of kB. Composed of alpha, beta and gamma subunits, the latter not having kinase activity but presumed to play a regulatory role." [GOC:ma] synonym: "IKK complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0008386 name: cholesterol monooxygenase (side-chain-cleaving) activity namespace: molecular_function def: "Catalysis of the reaction: cholesterol + reduced adrenal ferredoxin + O2 = pregnenolone + 4-methylpentanal + oxidized adrenal ferredoxin + H2O." [EC:1.14.15.6] synonym: "C27-side chain cleavage enzyme" RELATED [EC:1.14.15.6] synonym: "cholesterol 20-22-desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C(20-22) desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol C20-22 desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol desmolase activity" EXACT [EC:1.14.15.6] synonym: "cholesterol side-chain cleavage enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol side-chain-cleaving enzyme activity" RELATED [EC:1.14.15.6] synonym: "cholesterol,reduced-adrenal-ferredoxin:oxygen oxidoreductase (side-chain-cleaving)" EXACT [EC:1.14.15.6] synonym: "Cyp11a1" NARROW [] synonym: "cytochrome P-450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome P-450scc" RELATED [EC:1.14.15.6] synonym: "cytochrome p450(scc) activity" NARROW [EC:1.14.15.6] synonym: "cytochrome p450scc" RELATED [EC:1.14.15.6] synonym: "desmolase, steroid 20-22" EXACT [EC:1.14.15.6] synonym: "enzymes, cholesterol side-chain-cleaving" RELATED [EC:1.14.15.6] synonym: "steroid 20-22 desmolase activity" BROAD [EC:1.14.15.6] synonym: "steroid 20-22-lyase activity" BROAD [EC:1.14.15.6] xref: EC:1.14.15.6 xref: MetaCyc:1.14.15.6-RXN xref: Reactome:24219 "cholesterol monooxygenase (side-chain-cleaving) activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016713 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008387 name: steroid 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 7-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP2A12" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008388 name: testosterone 15-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 15-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2A4" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008389 name: coumarin 7-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: coumarin + O2 + NADPH + H+ = hydroxycoumarin + H2O + NADP+." [Reactome:163103] synonym: "cytochrome P450 CYP2A5" NARROW [] xref: Reactome:24222 "coumarin 7-hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008390 name: testosterone 16-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: testosterone + donor-H2 + O2 = 6-alpha-hydroxytestosterone + H2O." [GOC:ai] synonym: "cytochrome P450 CYP2B10" NARROW [] synonym: "cytochrome P450 CYP2B9" NARROW [] synonym: "cytochrome P450 CYP2D10" NARROW [] synonym: "cytochrome P450 CYP2D11" NARROW [] synonym: "cytochrome P450 CYP2D9" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008391 name: arachidonic acid monooxygenase activity namespace: molecular_function synonym: "cytochrome P450 CYP2B19" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008392 name: arachidonic acid epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to a cis-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2J5" NARROW [] synonym: "cytochrome P450 CYP2J6" NARROW [] xref: Reactome:24235 "arachidonic acid epoxygenase activity" is_a: GO:0008391 ! arachidonic acid monooxygenase activity [Term] id: GO:0008393 name: fatty acid (omega-1)-hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2E1" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008394 name: olfactory-specific steroid hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2G1" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008395 name: steroid hydroxylase activity namespace: molecular_function def: "Catalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2." [ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] xref: Reactome:12240 "steroid hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0008396 name: oxysterol 7-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: an oxysterol + NADPH + O2 = 7-alpha-hydroxylated oxysterol + NADP+ + H2O." [PMID:10882791] synonym: "cytochrome P450 CYP7B1" NARROW [] xref: Reactome:24238 "oxysterol 7-alpha-hydroxylase activity" is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008397 name: sterol 12-alpha-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: a steroid + donor-H2 + O2 = 12-alpha-hydroxysteroid + H2O." [GOC:mah] synonym: "cytochrome P450 CYP8B1" NARROW [] is_a: GO:0008395 ! steroid hydroxylase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008398 name: sterol 14-demethylase activity namespace: molecular_function def: "Catalysis of the reaction: obtusifoliol + 3 O2 + 3 NADPH + 3 H+ = 4-alpha-methyl-5-alpha-ergosta-8,14,24(28)-trien-3-beta-ol + formate + 3 NADP+ + 3 H2O." [EC:1.14.13.70] subset: gosubset_prok synonym: "cytochrome P450 51 activity" NARROW [EC:1.14.13.70] synonym: "cytochrome P450 CYP51" NARROW [] synonym: "lanosterol 14-alpha-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "lanosterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "obtusufoliol 14-demethylase activity" NARROW [EC:1.14.13.70] synonym: "sterol 14-alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol 14alpha-demethylase activity" EXACT [EC:1.14.13.70] synonym: "sterol,NADPH:oxygen oxidoreductase (14-methyl cleaving)" EXACT [EC:1.14.13.70] xref: EC:1.14.13.70 xref: MetaCyc:1.14.13.70-RXN xref: Reactome:24240 "sterol 14-demethylase activity" is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen is_a: GO:0032451 ! demethylase activity [Term] id: GO:0008399 name: naphthalene hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP2F2" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008401 name: retinoic acid 4-hydroxylase activity namespace: molecular_function synonym: "cytochrome P450 CYP261" NARROW [] xref: Reactome:24496 "retinoic acid 4-hydroxylase activity" is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008403 name: 25-hydroxycholecalciferol-24-hydroxylase activity namespace: molecular_function alt_id: GO:0030344 def: "Catalysis of the hydroxylation of C-24 of 25-hydroxycholecalciferol (25-hydroxyvitamin D3) to form 24(R),25-dihydroxycholecalciferol." [ISBN:0471331309 "Biochemical Pathways"] synonym: "25-hydroxyvitamin D3 24-hydroxylase activity" EXACT [] synonym: "cytochrome P450 CYP24" NARROW [] is_a: GO:0004497 ! monooxygenase activity is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen is_a: GO:0070576 ! vitamin D 24-hydroxylase activity [Term] id: GO:0008404 name: arachidonic acid 14,15-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-14,15-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C29" NARROW [] synonym: "cytochrome P450 CYP2C39" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008405 name: arachidonic acid 11,12-epoxygenase activity namespace: molecular_function def: "Catalysis of an NADPH- and oxygen-dependent reaction that converts arachidonic acid to cis-11,12-epoxyeicosatrienoic acid." [http://lipidlibrary.aocs.org/Lipids/eic_hete/index.htm, PMID:10681399] synonym: "cytochrome P450 CYP2C38" NARROW [] is_a: GO:0008392 ! arachidonic acid epoxygenase activity [Term] id: GO:0008406 name: gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the gonad over time, from its formation to the mature structure. The gonad is an animal organ that produces gametes; in some species it also produces hormones." [GOC:ems, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0048513 ! organ development is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0045137 ! development of primary sexual characteristics [Term] id: GO:0008407 name: bristle morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the bristle are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0022416 ! bristle development [Term] id: GO:0008408 name: 3'-5' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end." [GOC:ai] subset: gosubset_prok synonym: "3'-5'-exonuclease activity" EXACT [] is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008409 name: 5'-3' exonuclease activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 5' end." [GOC:ai] subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008410 name: CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor)." [GOC:jl] subset: gosubset_prok xref: EC:2.8.3.- is_a: GO:0016782 ! transferase activity, transferring sulfur-containing groups [Term] id: GO:0008411 name: 4-hydroxybutyrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the transfer of a coenzyme A (CoA) group to 4-hydroxybutyrate." [GOC:jl] subset: gosubset_prok is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008412 name: 4-hydroxybenzoate octaprenyltransferase activity namespace: molecular_function alt_id: GO:0000043 alt_id: GO:0048043 alt_id: GO:0048044 def: "Catalysis of the reaction: farnesylfarnesylgeranyl-PP + p-hydroxybenzoate = 3-octaprenyl-4-hydroxybenzoate + diphosphate." [MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN] subset: gosubset_prok synonym: "4-HB polyprenyltransferase activity" EXACT [] synonym: "para-hydroxybenzoate transferase activity" EXACT [] synonym: "para-hydroxybenzoate-polyprenyl diphosphate transferase activity" EXACT [] synonym: "para-hydroxybenzoate:polyprenyltransferase activity" EXACT [] synonym: "PHB polyprenyl diphosphate transferase activity" EXACT [] xref: EC:2.5.1.- xref: MetaCyc:4OHBENZOATE-OCTAPRENYLTRANSFER-RXN is_a: GO:0002094 ! polyprenyltransferase activity [Term] id: GO:0008413 name: 8-oxo-7,8-dihydroguanosine triphosphate pyrophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-Oxo-GTP) = 8-oxo-7,8-dihydroguanosine phosphate (8-Oxo-GMP) + diphosphate. 8-Oxo-GTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription." [PMID:15878881] subset: gosubset_prok synonym: "7,8-dihydro-8-oxoguanine-triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanine triphosphatase activity" EXACT [] synonym: "8-oxo-7,8-dihydroguanosine triphosphatase activity" EXACT [] synonym: "8-oxo-GTPase activity" EXACT [] xref: EC:3.6.1.- is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008414 name: CDP-alcohol phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a CDP-alcohol group from one compound to another." [GOC:jl] is_a: GO:0016740 ! transferase activity [Term] id: GO:0008415 name: acyltransferase activity namespace: molecular_function def: "Catalysis of the generalized reaction: acyl-carrier + reactant = acyl-reactant + carrier." [EC:2.3.1.-, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: EC:2.3.1.- xref: Reactome:1091 "acyltransferase activity" is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008416 name: delta5-delta2,4-dienoyl-CoA isomerase activity namespace: molecular_function xref: EC:5.3.3.- is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008417 name: fucosyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a fucosyl group to an acceptor molecule, typically another carbohydrate or a lipid." [GOC:ai] subset: gosubset_prok xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008418 name: protein N-terminal asparagine amidohydrolase activity namespace: molecular_function xref: EC:3.5.1.- is_a: GO:0004067 ! asparaginase activity [Term] id: GO:0008419 name: RNA lariat debranching enzyme activity namespace: molecular_function is_a: GO:0016891 ! endoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008420 name: CTD phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phospho-(DNA-directed RNA polymerase) + H2O = (DNA-directed RNA polymerase) + phosphate." [EC:3.1.3.16] is_a: GO:0004722 ! protein serine/threonine phosphatase activity [Term] id: GO:0008421 name: long-chain fatty-acyl-glutamate deacylase activity namespace: molecular_function def: "Catalysis of the reaction: N-long-chain-fatty-acyl-L-glutamate + H2O = a fatty acid anion + L-glutamate." [EC:3.5.1.55] synonym: "long-chain acylglutamate amidase activity" EXACT [EC:3.5.1.55] synonym: "long-chain aminoacylase activity" EXACT [EC:3.5.1.55] synonym: "long-chain fatty acyl-glutamate deacylase activity" EXACT [GOC:mah] synonym: "long-chain-fatty-acyl-glutamate deacylase activity" EXACT [] synonym: "N-long-chain-fatty-acyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.55] xref: EC:3.5.1.55 xref: MetaCyc:3.5.1.55-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008422 name: beta-glucosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal, non-reducing beta-D-glucose residues with release of beta-D-glucose." [EC:3.2.1.21] subset: gosubset_prok synonym: "amygdalase activity" NARROW [EC:3.2.1.21] synonym: "amygdalinase" BROAD [EC:3.2.1.21] synonym: "arbutinase activity" EXACT [EC:3.2.1.21] synonym: "aryl-beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-1,6-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "beta-D-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "beta-glucoside glucohydrolase activity" EXACT [EC:3.2.1.21] synonym: "cellobiase activity" NARROW [EC:3.2.1.21] synonym: "elaterase activity" NARROW [EC:3.2.1.21] synonym: "emulsin" RELATED [EC:3.2.1.21] synonym: "gentiobiase activity" NARROW [EC:3.2.1.21] synonym: "gentobiase activity" NARROW [EC:3.2.1.21] synonym: "limarase activity" NARROW [EC:3.2.1.21] synonym: "p-nitrophenyl beta-glucosidase activity" EXACT [EC:3.2.1.21] synonym: "primeverosidase activity" NARROW [EC:3.2.1.21] synonym: "salicilinase activity" NARROW [EC:3.2.1.21] xref: EC:3.2.1.21 xref: MetaCyc:3.2.1.21-RXN is_a: GO:0015926 ! glucosidase activity [Term] id: GO:0008423 name: bleomycin hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the inactivation of bleomycin B2 (a cytotoxic glycometallopeptide) by hydrolysis of a peptide bond of beta-aminoalanine, but also shows general aminopeptidase activity. The specificity varies somewhat with source, but amino acid arylamides of Met, Leu and Ala are preferred." [EC:3.4.22.40] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminopeptidase C (Lactococcus lactis)" NARROW [EC:3.4.22.40] xref: EC:3.4.22.40 xref: MetaCyc:3.4.22.40-RXN is_obsolete: true replaced_by: GO:0004197 [Term] id: GO:0008424 name: glycoprotein 6-alpha-L-fucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-L-fucose + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-N-acetyl-beta-D-glucosaminyl}asparagine = GDP + N4-{N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,3)-[N-acetyl-beta-D-glucosaminyl-(1,2)-alpha-D-mannosyl-(1,6)]-beta-D-mannosyl-(1,4)-N-acetyl-beta-D-glucosaminyl-(1,4)-[alpha-L-fucosyl-(1,6)]-N-acetyl-beta-D-glucosaminyl}asparagine." [EC:2.4.1.68] synonym: "FucT" RELATED [EC:2.4.1.68] synonym: "GDP-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-Fuc:N-acetyl-beta-D-glucosaminide alpha-(1->6)fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDP-L-fucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "GDPfucose-glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] synonym: "glycoprotein fucosyltransferase activity" BROAD [EC:2.4.1.68] synonym: "guanosine diphosphofucose--glycoprotein fucosyltransferase activity" EXACT [EC:2.4.1.68] xref: EC:2.4.1.68 xref: MetaCyc:2.4.1.68-RXN is_a: GO:0046921 ! alpha(1,6)-fucosyltransferase activity [Term] id: GO:0008425 name: 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: 2-polyprenyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-methionine = 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinone + S-adenosyl-L-homocysteine." [GOC:kd, PMID:9083048] subset: gosubset_prok synonym: "2-polyprenyl-6-methoxy-1,4-benzoquinone methylase activity" EXACT [] synonym: "coenzyme Q biosynthesis methyltransferase activity" EXACT [] synonym: "coenzyme Q biosynthetic process methyltransferase activity" EXACT [] synonym: "ubiquinone biosynthesis methyltransferase activity" BROAD [] synonym: "ubiquinone biosynthetic process methyltransferase activity" BROAD [] xref: EC:2.1.1.- is_a: GO:0030580 ! quinone cofactor methyltransferase activity [Term] id: GO:0008426 name: protein kinase C inhibitor activity namespace: molecular_function alt_id: GO:0004863 def: "Stops, prevents or reduces the activity of protein kinase C, an enzyme which phosphorylates a protein." [GOC:ai] synonym: "diacylglycerol-activated phospholipid-dependent PKC inhibitor activity" EXACT [] synonym: "diacylglycerol-activated phospholipid-dependent protein kinase C inhibitor activity" EXACT [] synonym: "PKC inhibitor activity" EXACT [] is_a: GO:0030291 ! protein serine/threonine kinase inhibitor activity relationship: negatively_regulates GO:0004697 ! protein kinase C activity [Term] id: GO:0008427 name: calcium-dependent protein kinase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a calcium-dependent protein kinase." [GOC:mah] is_a: GO:0004860 ! protein kinase inhibitor activity is_a: GO:0010858 ! calcium-dependent protein kinase regulator activity [Term] id: GO:0008428 name: ribonuclease inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a ribonuclease, any enzyme that catalyzes the hydrolysis of phosphodiester bonds in chains of RNA." [GOC:ai] subset: gosubset_prok is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0004540 ! ribonuclease activity [Term] id: GO:0008429 name: phosphatidylethanolamine binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylethanolamine, any of a class of glycerophospholipids in which a phosphatidyl group is esterified to the hydroxyl group of ethanolamine." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005543 ! phospholipid binding [Term] id: GO:0008430 name: selenium binding namespace: molecular_function def: "Interacting selectively and non-covalently with selenium (Se)." [GOC:ai] subset: gosubset_prok is_a: GO:0005488 ! binding [Term] id: GO:0008431 name: vitamin E binding namespace: molecular_function def: "Interacting selectively and non-covalently with vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [http://cancerweb.ncl.ac.uk/, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] subset: gosubset_prok synonym: "alpha-tocopherol binding" NARROW [] synonym: "tocopherol binding" EXACT [] is_a: GO:0019842 ! vitamin binding [Term] id: GO:0008432 name: JUN kinase binding namespace: molecular_function def: "Interacting selectively and non-covalently with JUN kinase, an enzyme that catalyzes the phosphorylation and activation of members of the JUN family." [GOC:jl] is_a: GO:0019901 ! protein kinase binding [Term] id: GO:0008434 name: vitamin D3 receptor activity namespace: molecular_function def: "Combining with vitamin D3, cholecalciferol, to initiate a change in cell activity." [GOC:ai] comment: Note that this term represents a function and not a gene product. Consider also annotating to the molecular function term 'transcription regulator activity ; GO:0030528'. synonym: "cholecaliferol receptor activity" EXACT [] is_a: GO:0004879 ! ligand-dependent nuclear receptor activity relationship: part_of GO:0070561 ! vitamin D receptor signaling pathway [Term] id: GO:0008435 name: anticoagulant activity namespace: molecular_function def: "OBSOLETE. Functions to retard or prevent coagulation. Often used in the context of blood or milk coagulation." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0050819 [Term] id: GO:0008436 name: heterogeneous nuclear ribonucleoprotein namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it describes a cellular component rather than a molecular function. synonym: "hnRNP" EXACT [] is_obsolete: true replaced_by: GO:0030530 [Term] id: GO:0008437 name: thyrotropin-releasing hormone activity namespace: molecular_function def: "The action characteristic of thyrotropin-releasing hormone (TRH), a hormone released by the mammalian hypothalamus into the hypophyseal-portal circulation in response to neural and/or chemical stimuli. Upon receptor binding, TRH increases the secretion of thyroid-stimulating hormone by the anterior pituitary." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "thyrotropin releasing hormone activity" EXACT [] synonym: "TRH activity" EXACT [ISBN:0198506732] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008438 name: 1-phosphatidylinositol-5-phosphate kinase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: diphosphate + a purine nucleoside = phosphate + a purine mononucleotide." [EC:2.7.1.143] comment: This term was made obsolete because it is a redundant grouping term with only one child. It is also incorrectly defined and had an incorrect EC dbxref. is_obsolete: true consider: GO:0016309 [Term] id: GO:0008439 name: monophenol monooxygenase activator activity namespace: molecular_function def: "OBSOLETE. Increases the activity of the enzyme monophenol monooxygenase." [GOC:ai] comment: This term was made obsolete because it represents a gene product. synonym: "prophenol oxidase activator" RELATED [] is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008440 name: inositol trisphosphate 3-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 1D-myo-inositol 1,4,5-trisphosphate = ADP + 1D-myo-inositol 1,3,4,5-tetrakisphosphate." [EC:2.7.1.127] synonym: "1D-myo-inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ATP:1D-myo-inositol-1,4,5-trisphosphate 3-phosphotransferase activity" EXACT [EC:2.7.1.127] synonym: "inositol 1,4,5-trisphosphate 3-kinase activity" EXACT [] synonym: "inositol-trisphosphate 3-kinase activity" EXACT [] synonym: "ins(1,4,5)P(3) 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "Ins(1,4,5)P3 3-kinase activity" EXACT [EC:2.7.1.127] synonym: "IP3 3-kinase activity" NARROW [EC:2.7.1.127] synonym: "IP3K activity" NARROW [EC:2.7.1.127] xref: EC:2.7.1.127 xref: MetaCyc:2.7.1.127-RXN is_a: GO:0051766 ! inositol trisphosphate kinase activity [Term] id: GO:0008441 name: 3'(2'),5'-bisphosphate nucleotidase activity namespace: molecular_function def: "Catalysis of the reaction: adenosine 3',5'-bisphosphate + H2O = adenosine 5'-phosphate + phosphate." [EC:3.1.3.7] subset: gosubset_prok synonym: "3'(2'),5' bisphosphate nucleotidase activity" EXACT [] synonym: "3'(2'),5'-bisphosphonucleoside 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "3'-phosphoadenylylsulfate 3'-phosphatase activity" EXACT [EC:3.1.3.7] synonym: "adenosine-3'(2'),5'-bisphosphate 3'(2')-phosphohydrolase activity" EXACT [EC:3.1.3.7] synonym: "DPNPase activity" EXACT [EC:3.1.3.7] synonym: "phosphoadenylate 3'-nucleotidase activity" EXACT [EC:3.1.3.7] xref: EC:3.1.3.7 xref: MetaCyc:325-BISPHOSPHATE-NUCLEOTIDASE-RXN xref: Reactome:24620 "3'(2'),5'-bisphosphate nucleotidase activity" is_a: GO:0008252 ! nucleotidase activity [Term] id: GO:0008442 name: 3-hydroxyisobutyrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-hydroxy-2-methylpropanoate + NAD+ = 2-methyl-3-oxopropanoate + NADH + H+." [EC:1.1.1.31] subset: gosubset_prok xref: EC:1.1.1.31 xref: MetaCyc:3-HYDROXYISOBUTYRATE-DEHYDROGENASE-RXN xref: Reactome:24621 "3-hydroxyisobutyrate dehydrogenase activity" is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008443 name: phosphofructokinase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group, usually from ATP, to a fructose substrate molecule." [GOC:jl] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008444 name: CDP-diacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + glycerol 3-phosphate = CMP + 3-(3-phosphatidyl)-glycerol 1-phosphate." [EC:2.7.8.5] subset: gosubset_prok synonym: "3-phosphatidyl-1'-glycerol-3'-phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "CDP-diacylglycerol:sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol-sn-glycerol-3-phosphate 3-phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "CDPdiacylglycerol:sn-glycero-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "cytidine 5'-diphospho-1,2-diacyl-sn-glycerol (CDPdiglyceride):sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol 3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerol phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "glycerophosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] synonym: "PGP synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerol phosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerolphosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthase activity" EXACT [EC:2.7.8.5] synonym: "phosphatidylglycerophosphate synthetase activity" EXACT [EC:2.7.8.5] synonym: "sn-glycerol-3-phosphate phosphatidyltransferase activity" EXACT [EC:2.7.8.5] xref: EC:2.7.8.5 xref: MetaCyc:PHOSPHAGLYPSYN-RXN is_a: GO:0017169 ! CDP-alcohol phosphatidyltransferase activity [Term] id: GO:0008445 name: D-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: D-aspartate + H2O + O2 = oxaloacetate + NH3 + H2O2." [EC:1.4.3.1] synonym: "aspartic oxidase activity" EXACT [EC:1.4.3.1] synonym: "D-aspartate:oxygen oxidoreductase (deaminating)" EXACT [EC:1.4.3.1] synonym: "D-aspartic oxidase activity" EXACT [EC:1.4.3.1] xref: EC:1.4.3.1 xref: MetaCyc:D-ASPARTATE-OXIDASE-RXN is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008446 name: GDP-mannose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-mannose = GDP-4-dehydro-6-deoxy-D-mannose + H2O." [EC:4.2.1.47] subset: gosubset_prok synonym: "GDP-D-mannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-D-mannose dehydratase activity" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase (GDP-4-dehydro-6-deoxy-D-mannose-forming)" EXACT [EC:4.2.1.47] synonym: "GDP-mannose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.47] synonym: "GDPmannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "Gmd" RELATED [EC:4.2.1.47] synonym: "guanosine 5'-diphosphate-D-mannose oxidoreductase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose 4,6-dehydratase activity" EXACT [EC:4.2.1.47] synonym: "guanosine diphosphomannose oxidoreductase activity" EXACT [EC:4.2.1.47] xref: EC:4.2.1.47 xref: MetaCyc:GDPMANDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008447 name: L-ascorbate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: 2 L-ascorbate + O2 = 2 dehydroascorbate + 2 H2O." [EC:1.10.3.3] synonym: "AA oxidase activity" EXACT [EC:1.10.3.3] synonym: "AAO" RELATED [EC:1.10.3.3] synonym: "ascorbase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate dehydrogenase activity" EXACT [EC:1.10.3.3] synonym: "ascorbate oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] synonym: "ascorbic oxidase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:O2 oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbate:oxygen oxidoreductase activity" EXACT [EC:1.10.3.3] synonym: "L-ascorbic acid oxidase activity" EXACT [EC:1.10.3.3] xref: EC:1.10.3.3 xref: MetaCyc:L-ASCORBATE-OXIDASE-RXN is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008448 name: N-acetylglucosamine-6-phosphate deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-glucosamine 6-phosphate + H2O = D-glucosamine 6-phosphate + acetate." [EC:3.5.1.25] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylaminodeoxyglucosephosphate acetylhydrolase activity" EXACT [EC:3.5.1.25] synonym: "acetylglucosamine phosphate deacetylase activity" EXACT [EC:3.5.1.25] synonym: "N-acetyl-D-glucosamine-6-phosphate amidohydrolase activity" EXACT [EC:3.5.1.25] xref: EC:3.5.1.25 xref: MetaCyc:NAG6PDEACET-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008449 name: N-acetylglucosamine-6-sulfatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the 6-sulfate group of the N-acetyl-D-glucosamine 6-sulfate units of heparan sulfate and keratan sulfate." [EC:3.1.6.14] subset: gosubset_prok synonym: "2-acetamido-2-deoxy-D-glucose 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "acetylglucosamine 6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "chondroitinsulfatase" BROAD [EC:3.1.6.14] synonym: "glucosamine-6-sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetyl-D-glucosamine-6-sulfate 6-sulfohydrolase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine 6-sulfate sulfatase activity" EXACT [EC:3.1.6.14] synonym: "N-acetylglucosamine-6-sulphatase activity" EXACT [] synonym: "O,N-disulfate O-sulfohydrolase activity" EXACT [EC:3.1.6.14] xref: EC:3.1.6.14 xref: MetaCyc:3.1.6.14-RXN is_a: GO:0008484 ! sulfuric ester hydrolase activity [Term] id: GO:0008450 name: O-sialoglycoprotein endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of O-sialoglycoproteins; cleaves the -Arg31-Asp32- bond in glycophorin A. Does not cleave unglycosylated proteins, desialylated glycoproteins or glycoproteins that are only N-glycosylated." [EC:3.4.24.57] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "glycophorin A proteinase activity" EXACT [EC:3.4.24.57] synonym: "glycoprotease activity" RELATED [EC:3.4.24.57] synonym: "glycoproteinase activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoprotease activity" EXACT [EC:3.4.24.57] synonym: "sialoglycoproteinase activity" EXACT [EC:3.4.24.57] xref: EC:3.4.24.57 xref: MetaCyc:3.4.24.57-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008451 name: X-Pro aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of any N-terminal amino acid, including proline, that is linked with proline, even from a dipeptide or tripeptide." [EC:3.4.11.9] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminoacylproline aminopeptidase activity" EXACT [EC:3.4.11.9] synonym: "aminopeptidase P" EXACT [] synonym: "proline aminopeptidase" BROAD [EC:3.4.11.9] synonym: "Xaa-Pro aminopeptidase activity" EXACT [] xref: EC:3.4.11.9 xref: MetaCyc:3.4.11.9-RXN is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0008452 name: RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between a hydroxyl group at the end of one RNA chain and the 5'-phosphate group at the end of another." [GOC:mah] subset: gosubset_prok xref: EC:6.5.1.- is_a: GO:0016886 ! ligase activity, forming phosphoric ester bonds [Term] id: GO:0008453 name: alanine-glyoxylate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine + glyoxylate = pyruvate + glycine." [EC:2.6.1.44] subset: gosubset_prok synonym: "AGT activity" EXACT [EC:2.6.1.44] synonym: "alanine--glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "alanine-glyoxylate aminotransferase activity" EXACT [] synonym: "alanine-glyoxylic aminotransferase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine-glycine transaminase activity" EXACT [EC:2.6.1.44] synonym: "L-alanine:glyoxylate aminotransferase activity" EXACT [EC:2.6.1.44] xref: EC:2.6.1.44 xref: MetaCyc:ALANINE--GLYOXYLATE-AMINOTRANSFERASE-RXN xref: Reactome:24651 "alanine-glyoxylate transaminase activity" is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008454 name: alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + (N-acetyl-beta-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,4-(N-acetyl-D-glucosaminyl-1,2)-alpha-D-mannosyl-1,3-(beta-N-acetyl-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6)-beta-D-mannosyl-R." [EC:2.4.1.145] synonym: "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "alpha-1,3-mannosylglycoprotein beta-1,4-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "beta-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "GnTIV activity" EXACT [EC:2.4.1.145] synonym: "N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "UDP-N-acetyl-D-glucosamine:3-[2-(N-acetyl-beta-D-glucosaminyl)-alpha-D-mannosyl]-glycoprotein 4-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta-4-acetylglucosaminyltransferase IV activity" EXACT [EC:2.4.1.145] synonym: "uridine diphosphoacetylglucosamine-glycopeptide beta4-acetylglucosaminyltransferase IV" RELATED [EC:2.4.1.145] xref: EC:2.4.1.145 xref: MetaCyc:2.4.1.145-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008455 name: alpha-1,6-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,6-(N-acetyl-beta-D-glucosaminyl-1,2-alpha-D-mannosyl-1,3)-beta-D-mannosyl-R." [EC:2.4.1.143] synonym: "acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosyl-glycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "alpha-1,6-mannosylglycoprotein beta-1,2-N-acetylglucosaminyltransferase activity" EXACT [] synonym: "GnTII activity" EXACT [EC:2.4.1.143] synonym: "N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase II activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha-1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-GlcNAc:mannoside alpha1-6 acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "UDP-N-acetyl-D-glucosamine:6-(alpha-D-mannosyl)-beta-D-mannosyl-glycoprotein 2-beta-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-1,6-mannosylglycoprotein beta-1-2-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta-1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-alpha-D-mannoside beta1-2-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha-1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] synonym: "uridine diphosphoacetylglucosamine-mannoside alpha1->6-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.143] xref: EC:2.4.1.143 xref: MetaCyc:2.4.1.143-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008456 name: alpha-N-acetylgalactosaminidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-alpha-D-galactosaminides." [EC:3.2.1.49] synonym: "alpha-acetylgalactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "alpha-galactosidase B activity" RELATED [EC:3.2.1.49] synonym: "alpha-N-acetyl-D-galactosaminide N-acetylgalactosaminohydrolase activity" EXACT [EC:3.2.1.49] synonym: "alpha-NAGA activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-D-galactosaminidase activity" EXACT [EC:3.2.1.49] synonym: "N-acetyl-alpha-galactosaminidase activity" EXACT [EC:3.2.1.49] xref: EC:3.2.1.49 xref: MetaCyc:3.2.1.49-RXN is_a: GO:0015929 ! hexosaminidase activity [Term] id: GO:0008457 name: beta-galactosyl-N-acetylglucosaminylgalactosylglucosyl-ceramide beta-1,3-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide = UDP + N-acetyl-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide." [EC:2.4.1.163] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.163] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-beta-D-glucosylceramide beta-1,3-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.163] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.163] xref: EC:2.4.1.163 xref: MetaCyc:2.4.1.163-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008458 name: carnitine O-octanoyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: octanoyl-CoA + L-carnitine = CoA + L-octanoylcarnitine." [EC:2.3.1.137] synonym: "carnitine medium-chain acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "easily solubilized mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] synonym: "medium-chain/long-chain carnitine acyltransferase activity" EXACT [EC:2.3.1.137] synonym: "octanoyl-CoA:L-carnitine O-octanoyltransferase activity" EXACT [EC:2.3.1.137] synonym: "overt mitochondrial carnitine palmitoyltransferase" NARROW [EC:2.3.1.137] xref: EC:2.3.1.137 xref: MetaCyc:CARNITINE-O-OCTANOYLTRANSFERASE-RXN xref: Reactome:24659 "carnitine O-octanoyltransferase activity" is_a: GO:0016406 ! carnitine O-acyltransferase activity is_a: GO:0016414 ! O-octanoyltransferase activity [Term] id: GO:0008459 name: chondroitin 6-sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + chondroitin = adenosine 3',5'-bisphosphate + chondroitin 6'-sulfate." [EC:2.8.2.17] synonym: "3'-phosphoadenosine 5'-phosphosulfate (PAPS):chondroitin sulfate sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "3'-phosphoadenylyl-sulfate:chondroitin 6'-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-O-sulfotransferase activity" EXACT [EC:2.8.2.17] synonym: "chondroitin 6-sulphotransferase activity" EXACT [] synonym: "terminal 6-sulfotransferase activity" EXACT [EC:2.8.2.17] xref: EC:2.8.2.17 xref: MetaCyc:CHONDROITIN-6-SULFOTRANSFERASE-RXN is_a: GO:0034481 ! chondroitin sulfotransferase activity [Term] id: GO:0008460 name: dTDP-glucose 4,6-dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-D-glucose + H2O." [EC:4.2.1.46] subset: gosubset_prok synonym: "dTDP-glucose 4,6-hydro-lyase (dTDP-4-dehydro-6-deoxy-D-glucose-forming)" EXACT [EC:4.2.1.46] synonym: "dTDP-glucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-dehydratase activity" EXACT [EC:4.2.1.46] synonym: "dTDPglucose 4,6-hydro-lyase activity" EXACT [EC:4.2.1.46] synonym: "TDP-glucose oxidoreductase activity" EXACT [EC:4.2.1.46] synonym: "thymidine diphosphoglucose oxidoreductase activity" EXACT [EC:4.2.1.46] xref: EC:4.2.1.46 xref: MetaCyc:DTDPGLUCDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008462 name: endopeptidase Clp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of proteins to small peptides in the presence of ATP and magnesium. Alpha-casein is the usual test substrate. In the absence of ATP, only oligopeptides shorter than five residues are cleaved, for example, succinyl-Leu-Tyr-NHMec which is cleaved at the Tyr-NHMec bond, and Leu-Tyr-Leu-Tyr-Trp which is cleaved at the second Leu-Typ bond (cleavage of the Tyr-Leu and Tyr-Trp bonds also occurs)." [EC:3.4.21.92] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ATP-dependent Clp protease" NARROW [EC:3.4.21.92] synonym: "caseinolytic protease activity" RELATED [EC:3.4.21.92] synonym: "Clp protease" NARROW [EC:3.4.21.92] synonym: "ClpP" RELATED [EC:3.4.21.92] synonym: "endopeptidase Ti activity" RELATED [EC:3.4.21.92] synonym: "protease Ti activity" RELATED [EC:3.4.21.92] xref: EC:3.4.21.92 xref: MetaCyc:3.4.21.92-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008463 name: formylmethionine deformylase activity namespace: molecular_function def: "Catalysis of the reaction: N-formyl-L-methionine + H2O = formate + L-methionine." [EC:3.5.1.31] subset: gosubset_prok synonym: "N-formyl-L-methionine amidohydrolase activity" EXACT [EC:3.5.1.31] xref: EC:3.5.1.31 xref: MetaCyc:FORMYLMETHIONINE-DEFORMYLASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008464 name: gamma-glutamyl hydrolase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a gamma-glutamyl bond to release an unsubstituted C-terminal amino acid." [EC:3.4.19.9] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase G activity" BROAD [EC:3.4.19.9] synonym: "conjugase activity" RELATED [EC:3.4.19.9] synonym: "folate conjugase activity" RELATED [EC:3.4.19.9] synonym: "folic acid conjugase activity" EXACT [EC:3.4.19.9] synonym: "gamma-Glu-X carboxypeptidase activity" EXACT [EC:3.4.19.9] synonym: "lysosomal gamma-glutamyl carboxypeptidase activity" NARROW [EC:3.4.19.9] synonym: "poly(gamma-glutamic acid) endohydrolase activity" EXACT [EC:3.4.19.9] synonym: "poly(glutamic acid) hydrolase II" RELATED [EC:3.4.19.9] synonym: "polyglutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroyl-poly-alpha-glutamate hydrolase activity" NARROW [EC:3.4.19.9] synonym: "pteroyl-poly-gamma-glutamate hydrolase activity" EXACT [EC:3.4.19.9] synonym: "pteroylpoly-gamma-glutamyl hydrolase activity" EXACT [EC:3.4.19.9] xref: EC:3.4.19.9 xref: MetaCyc:3.4.19.9-RXN is_obsolete: true replaced_by: GO:0008242 [Term] id: GO:0008465 name: glycerate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NAD+ = hydroxypyruvate + NADH + H+." [EC:1.1.1.29] subset: gosubset_prok synonym: "hydroxypyruvate dehydrogenase activity" BROAD [EC:1.1.1.29] xref: EC:1.1.1.29 xref: MetaCyc:GLYCERATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008466 name: glycogenin glucosyltransferase activity namespace: molecular_function alt_id: GO:0047210 def: "Catalysis of the reaction: UDP-glucose + glycogenin = UDP + glucosylglycogenin." [EC:2.4.1.186] synonym: "1,4alpha-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "alpha-1,4-glucan-protein synthase (UDP-forming) activity" EXACT [] synonym: "glycogenin activity" RELATED [EC:2.4.1.186] synonym: "priming glucosyltransferase activity" RELATED [EC:2.4.1.186] synonym: "UDP-alpha-D-glucose:glycogenin alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.186] synonym: "UDP-glucose:glycogenin glucosyltransferase activity" EXACT [EC:2.4.1.186] xref: EC:2.4.1.186 xref: MetaCyc:GLYCOGENIN-GLUCOSYLTRANSFERASE-RXN xref: Reactome:24685 "glycogenin glucosyltransferase activity" is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008467 name: [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenylyl sulfate + [heparan sulfate]-glucosamine = adenosine 3',5'-bisphosphate + [heparan sulfate]-glucosamine 3-sulfate, with a substrate consensus sequence of Glc(N2S>NAc)+/-6S GlcA GlcN2S*+/-6S GlcA>IdoA+/-2S Glc(N2S/NAc)+/-6S." [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:[heparan sulfate]-glucosamine 3-sulfotransferase" BROAD [EC:2.8.2.23] synonym: "3'-phosphoadenylyl-sulfate:heparin-glucosamine 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "3-OST-1 activity" EXACT [EC:2.8.2.23] synonym: "glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparan sulfate D-glucosaminyl 3-O-sulfotransferase activity" EXACT [EC:2.8.2.23] synonym: "heparin-glucosamine 3-O-sulfotransferase activity" RELATED [] synonym: "heparin-glucosamine 3-O-sulphotransferase activity" RELATED [] synonym: "isoform/isozyme 1 (3-OST-1, HS3ST1)" RELATED [EC:2.8.2.23] xref: EC:2.8.2.23 xref: MetaCyc:2.8.2.23-RXN is_a: GO:0034483 ! heparan sulfate sulfotransferase activity [Term] id: GO:0008469 name: histone-arginine N-methyltransferase activity namespace: molecular_function alt_id: GO:0016276 def: "Catalysis of the reaction: S-adenosyl-L-methionine + histone-arginine = S-adenosyl-L-homocysteine + histone-N-methyl-arginine." [EC:2.1.1.125] synonym: "histone methyltransferase activity" BROAD [] synonym: "histone protein methylase activity" EXACT [EC:2.1.1.125] synonym: "histone protein methylase I" RELATED [EC:2.1.1.125] synonym: "histone-arginine N-methylase activity" EXACT [GOC:mah] synonym: "nuclear protein (histone) N-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "protein methylase I activity" BROAD [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine nomega-methyltransferase activity" EXACT [EC:2.1.1.125] synonym: "S-adenosyl-L-methionine:histone-arginine omega-N-methyltransferase activity" EXACT [EC:2.1.1.125] xref: EC:2.1.1.125 xref: MetaCyc:2.1.1.125-RXN is_a: GO:0016274 ! protein-arginine N-methyltransferase activity is_a: GO:0042054 ! histone methyltransferase activity relationship: part_of GO:0034969 ! histone arginine methylation [Term] id: GO:0008470 name: isovaleryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-methylbutanoyl-CoA + ETF = 3-methylbut-2-enoyl-CoA + reduced ETF." [EC:1.3.99.10] subset: gosubset_prok synonym: "3-methylbutanoyl-CoA:(acceptor) oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "3-methylbutanoyl-CoA:acceptor oxidoreductase activity" EXACT [EC:1.3.99.10] synonym: "isovaleroyl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] synonym: "isovaleryl-coenzyme A dehydrogenase activity" EXACT [EC:1.3.99.10] xref: EC:1.3.99.10 xref: MetaCyc:ISOVALERYL-COA-FAD-RXN xref: Reactome:24705 "isovaleryl-CoA dehydrogenase activity" is_a: GO:0003995 ! acyl-CoA dehydrogenase activity [Term] id: GO:0008471 name: laccase activity namespace: molecular_function def: "Catalysis of the reaction: 4 benzenediol + O2 = 4 benzosemiquinone + 2 H2O." [EC:1.10.3.2] subset: gosubset_prok synonym: "benzenediol:oxygen oxidoreductase activity" EXACT [EC:1.10.3.2] synonym: "p-diphenol oxidase activity" EXACT [EC:1.10.3.2] synonym: "urishiol oxidase activity" RELATED [EC:1.10.3.2] synonym: "urushiol oxidase activity" EXACT [EC:1.10.3.2] xref: EC:1.10.3.2 xref: MetaCyc:LACCASE-RXN xref: UM-BBD_enzymeID:e0629 is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008472 name: metallocarboxypeptidase D activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: peptidyl-L-lysine (or peptidyl-L-arginine) + H2O = peptide + L-lysine (or L-arginine). Function is activated by Co2+; inhibited by guanidinoethylmercaptosuccinic acid." [EC:3.4.17.22] comment: This term was made obsolete because it represents a gene product. synonym: "carboxypeptidase D (cattle, human, mouse, rat)" RELATED [EC:3.4.17.22] synonym: "gp180 (duck)" RELATED [EC:3.4.17.22] xref: EC:3.4.17.22 xref: MetaCyc:3.4.17.22-RXN is_obsolete: true replaced_by: GO:0004181 [Term] id: GO:0008473 name: ornithine cyclodeaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-ornithine = L-proline + NH3." [EC:4.3.1.12] subset: gosubset_prok synonym: "L-ornithine ammonia-lyase (cyclizing)" EXACT [EC:4.3.1.12] synonym: "L-ornithine ammonia-lyase (cyclizing; L-proline-forming)" EXACT [EC:4.3.1.12] synonym: "OCD activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase (deaminating) activity" EXACT [EC:4.3.1.12] synonym: "ornithine cyclase activity" EXACT [EC:4.3.1.12] xref: EC:4.3.1.12 xref: MetaCyc:ORNITHINE-CYCLODEAMINASE-RXN is_a: GO:0016841 ! ammonia-lyase activity is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008474 name: palmitoyl-(protein) hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: palmitoyl-protein + H2O = palmitate + protein." [EC:3.1.2.22] synonym: "palmitoyl-[protein] hydrolase" BROAD [EC:3.1.2.22] synonym: "palmitoyl-protein hydrolase activity" EXACT [] synonym: "palmitoyl-protein thioesterase activity" EXACT [] synonym: "palmitoyl-protein thiolesterase activity" EXACT [] xref: EC:3.1.2.22 xref: MetaCyc:3.1.2.22-RXN xref: Reactome:24711 "palmitoyl-(protein) hydrolase activity" is_a: GO:0016790 ! thiolester hydrolase activity [Term] id: GO:0008475 name: procollagen-lysine 5-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: procollagen L-lysine + 2-oxoglutarate + O2 = procollagen 5-hydroxy-L-lysine + succinate + CO2." [EC:1.14.11.4] synonym: "collagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "lysine hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysine,2-oxoglutarate 5-dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysine-2-oxoglutarate dioxygenase activity" BROAD [EC:1.14.11.4] synonym: "lysyl hydroxylase activity" BROAD [EC:1.14.11.4] synonym: "lysylprotocollagen dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "procollagen-L-lysine,2-oxoglutarate:oxygen oxidoreductase (5-hydroxylating)" EXACT [EC:1.14.11.4] synonym: "procollagen-lysine,2-oxoglutarate 5-dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine dioxygenase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysine hydroxylase activity" EXACT [EC:1.14.11.4] synonym: "protocollagen lysyl hydroxylase activity" EXACT [EC:1.14.11.4] xref: EC:1.14.11.4 xref: MetaCyc:PROCOLLAGEN-LYSINE-5-DIOXYGENASE-RXN is_a: GO:0070815 ! peptidyl-lysine 5-dioxygenase activity [Term] id: GO:0008476 name: protein-tyrosine sulfotransferase activity namespace: molecular_function def: "Catalysis of the reaction: 3'-phosphoadenosine 5'-phosphosulfate + protein tyrosine = adenosine 3',5'-bisphosphate + protein tyrosine-O-sulfate." [EC:2.8.2.20] synonym: "3'-phosphoadenylyl-sulfate:protein-tyrosine O-sulfotransferase activity" EXACT [EC:2.8.2.20] synonym: "protein-tyrosine sulphotransferase activity" EXACT [] synonym: "tyrosylprotein sulfotransferase activity" EXACT [EC:2.8.2.20] xref: EC:2.8.2.20 xref: MetaCyc:PROTEIN-TYROSINE-SULFOTRANSFERASE-RXN is_a: GO:0008146 ! sulfotransferase activity [Term] id: GO:0008477 name: purine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: a N-D-ribosylpurine + H2O = a purine + D-ribose." [EC:3.2.2.1] subset: gosubset_prok synonym: "IAG-NH activity" RELATED [EC:3.2.2.1] synonym: "IAG-nucleoside hydrolase activity" RELATED [EC:3.2.2.1] synonym: "inosine-adenosine-guanosine preferring nucleoside hydrolase activity" NARROW [EC:3.2.2.1] synonym: "N-D-ribosylpurine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "N-ribosyl purine ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "nucleosidase activity" BROAD [EC:3.2.2.1] synonym: "nucleosidase g activity" NARROW [EC:3.2.2.1] synonym: "nucleoside hydrolase activity" BROAD [EC:3.2.2.1] synonym: "purine beta-ribosidase activity" EXACT [EC:3.2.2.1] synonym: "purine nucleosidase reaction" EXACT [] synonym: "purine nucleoside hydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine ribonucleosidase activity" EXACT [EC:3.2.2.1] synonym: "purine-nucleoside ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "purine-specific nucleoside N-ribohydrolase activity" EXACT [EC:3.2.2.1] synonym: "ribonucleoside hydrolase activity" EXACT [EC:3.2.2.1] xref: EC:3.2.2.1 xref: MetaCyc:PURINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008478 name: pyridoxal kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyridoxal = ADP + pyridoxal 5'-phosphate." [EC:2.7.1.35] subset: gosubset_prok synonym: "ATP:pyridoxal 5'-phosphotransferase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal 5-phosphate-kinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxal kinase (phosphorylating)" EXACT [EC:2.7.1.35] synonym: "pyridoxal phosphokinase activity" EXACT [EC:2.7.1.35] synonym: "pyridoxamine kinase activity" RELATED [EC:2.7.1.35] synonym: "pyridoxine kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B(6) kinase activity" RELATED [EC:2.7.1.35] synonym: "vitamin B6 kinase activity" RELATED [EC:2.7.1.35] xref: EC:2.7.1.35 xref: MetaCyc:PYRIDOXKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008479 name: queuine tRNA-ribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA guanine + queuine = tRNA queuine + guanine." [EC:2.4.2.29] subset: gosubset_prok synonym: "[tRNA]-guanine:queuine tRNA-D-ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "guanine insertion enzyme activity" RELATED [EC:2.4.2.29] synonym: "guanine, queuine-tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "Q-insertase activity" EXACT [EC:2.4.2.29] synonym: "queuine transfer ribonucleate ribosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "transfer ribonucleate glycosyltransferase activity" EXACT [EC:2.4.2.29] synonym: "tRNA guanine transglycosidase activity" EXACT [EC:2.4.2.29] synonym: "tRNA transglycosylase activity" EXACT [EC:2.4.2.29] synonym: "tRNA-guanine transglycosylase activity" EXACT [EC:2.4.2.29] xref: EC:2.4.2.29 xref: MetaCyc:QUEUOSINE-TRNA-RIBOSYLTRANSFERASE-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008480 name: sarcosine dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: sarcosine + acceptor + H2O = glycine + formaldehyde + reduced acceptor." [EC:1.5.99.1] subset: gosubset_prok synonym: "monomethylglycine dehydrogenase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine N-demethylase activity" EXACT [EC:1.5.99.1] synonym: "sarcosine:(acceptor) oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] synonym: "sarcosine:acceptor oxidoreductase (demethylating)" EXACT [EC:1.5.99.1] xref: EC:1.5.99.1 xref: MetaCyc:SARCOSINE-DEHYDROGENASE-RXN is_a: GO:0016645 ! oxidoreductase activity, acting on the CH-NH group of donors [Term] id: GO:0008481 name: sphinganine kinase activity namespace: molecular_function alt_id: GO:0001728 def: "Catalysis of the reaction: ATP + sphinganine = ADP + sphinganine 1-phosphate." [EC:2.7.1.91] synonym: "ATP:sphinganine 1-phosphotransferase activity" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "dihydrosphingosine kinase activity" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase (phosphorylating)" EXACT [EC:2.7.1.91] synonym: "sphingosine kinase activity" RELATED [] xref: EC:2.7.1.91 xref: MetaCyc:SPHINGANINE-KINASE-RXN xref: Reactome:24730 "sphinganine kinase activity" is_a: GO:0001727 ! lipid kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008482 name: sulfite oxidase activity namespace: molecular_function def: "Catalysis of the reaction: SO3(2-) (sulfite) + O2 + H2O = SO4(2-) (sulfate) + H2O2." [EC:1.8.3.1] subset: gosubset_prok synonym: "sulfite:oxygen oxidoreductase activity" EXACT [EC:1.8.3.1] synonym: "sulphite oxidase activity" EXACT [] xref: EC:1.8.3.1 xref: MetaCyc:PWY-5326 xref: MetaCyc:SULFITE-OXIDASE-RXN is_a: GO:0016670 ! oxidoreductase activity, acting on sulfur group of donors, oxygen as acceptor [Term] id: GO:0008483 name: transaminase activity namespace: molecular_function def: "Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "aminotransferase activity" EXACT [] xref: EC:2.6.1 is_a: GO:0016769 ! transferase activity, transferring nitrogenous groups [Term] id: GO:0008484 name: sulfuric ester hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of any sulfuric ester bond, any ester formed from sulfuric acid, O=SO(OH)2." [GOC:ai] subset: gosubset_prok synonym: "sulfatase activity" EXACT [] synonym: "sulphuric ester hydrolase activity" EXACT [] xref: EC:3.1.6 xref: MetaCyc:ARYLSULFAT-RXN is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008486 name: diphosphoinositol-polyphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: diphospho-myo-inositol polyphosphate + H2O = myo-inositol polyphosphate + phosphate." [EC:3.6.1.52] synonym: "diphospho-myo-inositol-polyphosphate diphosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "diphosphoinositol polyphosphate phosphohydrolase activity" EXACT [] synonym: "diphosphoinositol-polyphosphate phosphohydrolase activity" EXACT [EC:3.6.1.52e] synonym: "DIPP activity" EXACT [EC:3.6.1.52e] xref: EC:3.6.1.52 xref: MetaCyc:3.6.1.52-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008487 name: prenyl-dependent CAAX protease activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008488 name: gamma-glutamyl carboxylase activity namespace: molecular_function subset: gosubset_prok xref: EC:4.1.1.- xref: Reactome:24735 "gamma-glutamyl carboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008489 name: UDP-galactose:glucosylceramide beta-1,4-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + glucosylceramide = lactosylceramide (galactosyl-beta-1,4-glucosylceramide) + UDP." [GOC:ai, PMID:9593693] synonym: "LacCer synthase activity" EXACT [] synonym: "lactosylceramide synthase activity" EXACT [] synonym: "UDP-galactose glucosylceramide beta-1,4-galactosyltransferase activity" EXACT [] is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008490 name: arsenite secondary active transmembrane transporter activity namespace: molecular_function alt_id: GO:0008491 def: "Catalysis of the transfer of arsenite from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:jl] subset: gosubset_prok synonym: "arsenite porter activity" RELATED [] is_a: GO:0015105 ! arsenite transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008492 name: cAMP generating peptide activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it describes a gene product. synonym: "cyclic AMP generating peptide activity" EXACT [] is_obsolete: true consider: GO:0004016 consider: GO:0005179 consider: GO:0046058 [Term] id: GO:0008493 name: tetracycline transporter activity namespace: molecular_function def: "Enables the directed movement of tetracycline into, out of, within or between cells. Tetracycline is a broad spectrum antibiotic that blocks binding of aminoacyl tRNA to the ribosomes of both Gram-positive and Gram-negative organisms (and those of organelles)." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "tetracyclin transporter activity" EXACT [] is_a: GO:0042895 ! antibiotic transporter activity relationship: part_of GO:0015904 ! tetracycline transport [Term] id: GO:0008494 name: translation activator activity namespace: molecular_function def: "Any of a group of soluble proteins functioning in the activation of ribosome-mediated translation of mRNA into a polypeptide." [GOC:ai] is_a: GO:0090079 ! translation regulator activity, nucleic acid binding relationship: part_of GO:0045727 ! positive regulation of translation [Term] id: GO:0008495 name: protoheme IX farnesyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "haem O synthase activity" EXACT [] synonym: "heme O synthase activity" EXACT [] synonym: "protohaem IX farnesyltransferase activity" EXACT [] xref: EC:2.5.1.- is_a: GO:0004311 ! farnesyltranstransferase activity [Term] id: GO:0008496 name: mannan endo-1,6-alpha-mannosidase activity namespace: molecular_function def: "Catalysis of the random hydrolysis of 1,6-alpha-D-mannosidic linkages in unbranched 1,6-mannans." [EC:3.2.1.101] synonym: "1,6-alpha-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "1,6-beta-D-mannan mannanohydrolase activity" EXACT [EC:3.2.1.101] synonym: "endo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-1->6-D-mannanase activity" EXACT [EC:3.2.1.101] synonym: "endo-alpha-D-mannosidase activity" EXACT [] synonym: "exo-1,6-beta-mannanase activity" EXACT [EC:3.2.1.101] synonym: "mannan endo-1,6-beta-mannosidase activity" EXACT [EC:3.2.1.101] xref: EC:3.2.1.101 xref: MetaCyc:3.2.1.101-RXN is_a: GO:0004559 ! alpha-mannosidase activity [Term] id: GO:0008498 name: phospholipid scrambling namespace: molecular_function def: "OBSOLETE. The trans-bilayer migration of phospholipids accelerated by a phospholipid scramblase upon binding calcium ions." [OMIM:604170] comment: This term was made obsolete because it represents a biological process and not a molecular function. is_obsolete: true replaced_by: GO:0017121 [Term] id: GO:0008499 name: UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-acetylglucosamine = galactose-beta-1,3-N-acetylglucosamine + UDP." [PMID:10212226] synonym: "beta-1,3-GalTase activity" BROAD [] synonym: "beta3Gal-Ts activity" BROAD [] synonym: "UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity" EXACT [] is_a: GO:0035250 ! UDP-galactosyltransferase activity is_a: GO:0048531 ! beta-1,3-galactosyltransferase activity [Term] id: GO:0008500 name: glycine-, glutamate-, thienylcyclohexylpiperidine binding namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it is a conglomeration of three terms. is_obsolete: true consider: GO:0016594 consider: GO:0016595 consider: GO:0016596 [Term] id: GO:0008502 name: melatonin receptor activity namespace: molecular_function def: "Combining with melatonin, N-acetyl-5-methoxytryptamine, to initiate a change in cell activity. Melatonin is a neuroendocrine substance that stimulates the aggregation of melanosomes in melanophores, thus lightening the skin." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008503 name: benzodiazepine receptor activity namespace: molecular_function def: "Combining with benzodiazepines, a class of drugs with hypnotic, anxiolytic, anticonvulsive, amnestic and myorelaxant properties, to initiate a change in cell activity." [GOC:jl] comment: Note that this term represents an activity and not a gene product. Consider also annotating to the molecular function terms 'chloride channel activity ; GO:0005254', 'GABA receptor activity ; GO:0016917' and 'inhibitory extracellular ligand-gated ion channel activity ; GO:0005237'. is_a: GO:0030594 ! neurotransmitter receptor activity [Term] id: GO:0008504 name: monoamine transmembrane transporter activity namespace: molecular_function alt_id: GO:0015201 def: "Catalysis of the transfer of monoamines, organic compounds that contain one amino group that is connected to an aromatic ring by an ethylene group (-CH2-CH2-), from one side of the membrane to the other." [ChEBI:25375, GOC:mah] xref: Reactome:22834 "monoamine transmembrane transporter activity" is_a: GO:0005275 ! amine transmembrane transporter activity relationship: part_of GO:0015844 ! monoamine transport [Term] id: GO:0008506 name: sucrose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + H+(out) = sucrose(in) + H+(in)." [TC:2.A.1.5.3] synonym: "hydrogen/sucrose transporter activity" BROAD [] synonym: "sucrose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0008515 ! sucrose transmembrane transporter activity [Term] id: GO:0008507 name: sodium:iodide symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: iodide(out) + Na+(out) = iodide(in) + Na+(in)." [TC:2.A.21.5.1] synonym: "sodium/iodide symporter activity" EXACT [] xref: Reactome:24854 "sodium:iodide symporter activity" is_a: GO:0015373 ! monovalent anion:sodium symporter activity [Term] id: GO:0008508 name: bile acid:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: bile acid(out) + Na+(out) = bile acid(in) + Na+(in)." [TC:2.A.28.-.-] synonym: "sodium/bile acid symporter activity" EXACT [] xref: Reactome:24856 "bile acid:sodium symporter activity" is_a: GO:0005343 ! organic acid:sodium symporter activity is_a: GO:0015125 ! bile acid transmembrane transporter activity [Term] id: GO:0008509 name: anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a negatively charged ion from one side of a membrane to the other." [GOC:def, GOC:df, GOC:mtg_transport, ISBN:0815340729] subset: gosubset_prok synonym: "anion transporter activity" EXACT [] xref: Reactome:3160 "anion transmembrane transporter activity" is_a: GO:0015075 ! ion transmembrane transporter activity relationship: part_of GO:0006820 ! anion transport [Term] id: GO:0008510 name: sodium:bicarbonate symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + HCO3-(out) = Na+(in) + HCO3-(in)." [TC:2.A.31.2.1] synonym: "sodium/bicarbonate cotransporter activity" BROAD [] synonym: "sodium:bicarbonate cotransporter activity" BROAD [] xref: Reactome:24874 "sodium:bicarbonate symporter activity" is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015106 ! bicarbonate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008511 name: sodium:potassium:chloride symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Na+(out) + K+(out) + Cl-(out) = Na+(in) + K+(in) + Cl-(in)." [TC:2.A.30.1.1] synonym: "sodium/potassium/chloride symporter activity" EXACT [] xref: Reactome:24875 "sodium:potassium:chloride symporter activity" is_a: GO:0015377 ! cation:chloride symporter activity [Term] id: GO:0008512 name: sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in)." [TC:2.A.53.-.-] synonym: "sulfate/hydrogen symporter activity" EXACT [] synonym: "sulfate:proton symporter activity" EXACT [] synonym: "sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008271 ! secondary active sulfate transmembrane transporter activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015295 ! solute:hydrogen symporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0008513 name: secondary active organic cation transmembrane transporter activity namespace: molecular_function synonym: "organic cation porter activity" RELATED [] is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008514 name: organic anion transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of organic anions from one side of a membrane to the other. Organic anions are atoms or small molecules with a negative charge which contain carbon in covalent linkage." [GOC:ai] subset: gosubset_prok is_a: GO:0008509 ! anion transmembrane transporter activity relationship: part_of GO:0015711 ! organic anion transport [Term] id: GO:0008515 name: sucrose transmembrane transporter activity namespace: molecular_function alt_id: GO:0019188 def: "Catalysis of the transfer of sucrose from one side of the membrane to the other. Sucrose is the disaccharide O-beta-D-fructofuranosyl-(2->1)-alpha-D-glucopyranoside, a sweet-tasting, non-reducing sugar isolated industrially from sugar beet or sugar cane." [GOC:mtg_transport, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0815340729] subset: gosubset_prok synonym: "sucrose permease (PTS) activity" EXACT [] synonym: "sucrose permease activity" RELATED [] is_a: GO:0015154 ! disaccharide transmembrane transporter activity relationship: part_of GO:0015770 ! sucrose transport [Term] id: GO:0008516 name: hexose uniporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) = hexose(in)." [TC:2.A.1.1.5] is_a: GO:0015149 ! hexose transmembrane transporter activity is_a: GO:0015292 ! uniporter activity [Term] id: GO:0008517 name: folic acid transporter activity namespace: molecular_function def: "Enables the directed movement of folic acid (pteroylglutamic acid) into, out of, within or between cells. Folic acid is widely distributed as a member of the vitamin B complex and is essential for the synthesis of purine and pyrimidines." [GOC:ai] synonym: "folate transporter activity" EXACT [] synonym: "vitamin B9 transporter activity" EXACT [] synonym: "vitamin M transporter activity" EXACT [] xref: Reactome:21930 "folic acid transporter activity" is_a: GO:0051183 ! vitamin transporter activity is_a: GO:0051184 ! cofactor transporter activity relationship: part_of GO:0015884 ! folic acid transport [Term] id: GO:0008518 name: reduced folate carrier activity namespace: molecular_function def: "Catalysis of the transfer of reduced folate from one side of a membrane to the other, up its concentration gradient. The transporter binds the solute and undergoes a series of conformational changes. Transport works equally well in either direction and is driven by a chemiosmotic source of energy. Chemiosmotic sources of energy include uniport, symport or antiport." [GOC:mtg_transport] synonym: "reduced folate transporter" BROAD [] is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0008519 name: ammonium transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of ammonium from one side of a membrane to the other. Ammonium is the cation NH4+ which is formed from N2 by root-nodule bacteria in leguminous plants and is an excretory product in ammonotelic animals." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Reactome:23077 "ammonium transmembrane transporter activity" is_a: GO:0015101 ! organic cation transmembrane transporter activity is_a: GO:0022890 ! inorganic cation transmembrane transporter activity relationship: part_of GO:0015696 ! ammonium transport [Term] id: GO:0008520 name: L-ascorbate:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ascorbate(out) + Na+(out) = ascorbate(in) + Na+(in)." [TC:2.A.40.6.1] synonym: "sodium-dependent L-ascorbic acid transporter" RELATED [] is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0008521 name: acetyl-CoA transporter activity namespace: molecular_function def: "Enables the directed movement of acetyl-CoA into, out of, within or between cells. Acetyl-CoA is a derivative of coenzyme A in which the sulfhydryl group is acetylated; it is a metabolite derived from several pathways (e.g. glycolysis, fatty acid oxidation, amino-acid catabolism) and is further metabolized by the tricarboxylic acid cycle. It is a key intermediate in lipid and terpenoid biosynthesis." [GOC:ai] is_a: GO:0051185 ! coenzyme transporter activity relationship: part_of GO:0015876 ! acetyl-CoA transport [Term] id: GO:0008523 name: sodium-dependent multivitamin transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: multivitamin(out) + Na+(out) = multivitamin(in) + Na+(in). Multivitamins include pantothenate, biotin and lipoate." [TC:2.A.21.5.2] xref: Reactome:24902 "sodium-dependent multivitamin transmembrane transporter activity" is_a: GO:0015370 ! solute:sodium symporter activity [Term] id: GO:0008524 name: glucose 6-phosphate:phosphate antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucose 6-phosphate(out) + phosphate(in) = glucose 6-phosphate(in) + phosphate(out)." [TC:2.A.1.-.-] is_a: GO:0015315 ! organophosphate:inorganic phosphate antiporter activity relationship: part_of GO:0005355 ! glucose transmembrane transporter activity [Term] id: GO:0008525 name: phosphatidylcholine transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylcholine into, out of, within or between cells. Phosphatidylcholine refers to a class of glycerophospholipids in which the phosphatidyl group is esterified to the hydroxyl group of choline." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008526 name: phosphatidylinositol transporter activity namespace: molecular_function def: "Enables the directed movement of phosphatidylinositol into, out of, within or between cells. Phosphatidylinositol refers to any glycophospholipids with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "phosphatidylinositol transfer" EXACT [] is_a: GO:0005548 ! phospholipid transporter activity [Term] id: GO:0008527 name: taste receptor activity namespace: molecular_function def: "Combining with soluble compounds to initiate a change in cell activity. These receptors are responsible for the sense of taste." [GOC:dph] synonym: "gustatory receptor" EXACT [] is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008528 name: peptide receptor activity, G-protein coupled namespace: molecular_function def: "Combining with an extracellular or intracellular peptide to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state." [GOC:dph, GOC:tb] synonym: "G protein coupled peptide receptor activity" EXACT [] synonym: "G-protein coupled peptide receptor activity" EXACT [] synonym: "G-protein-coupled peptide receptor activity" EXACT [] synonym: "peptide receptor activity, G protein coupled" EXACT [] is_a: GO:0001653 ! peptide receptor activity is_a: GO:0004930 ! G-protein coupled receptor activity [Term] id: GO:0008529 name: endogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an intracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0001653 consider: GO:0005622 [Term] id: GO:0008530 name: exogenous peptide receptor activity namespace: molecular_function def: "OBSOLETE. Combining with an extracellular peptide to initiate a change in cell activity." [GOC:ai] comment: This term was made obsolete because it contains both component and function information. is_obsolete: true consider: GO:0001653 consider: GO:0005576 [Term] id: GO:0008531 name: riboflavin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + riboflavin = ADP + FMN." [EC:2.7.1.26] subset: gosubset_prok synonym: "ATP:riboflavin 5'-phosphotransferase activity" EXACT [EC:2.7.1.26] synonym: "FK" RELATED [EC:2.7.1.26] synonym: "flavokinase activity" EXACT [EC:2.7.1.26] synonym: "riboflavin kinase (phosphorylating)" EXACT [EC:2.7.1.26] synonym: "riboflavine kinase activity" EXACT [EC:2.7.1.26] xref: EC:2.7.1.26 xref: MetaCyc:RIBOFLAVINKIN-RXN xref: Reactome:24927 "riboflavin kinase activity" is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008532 name: N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R = UDP + N-acetyl-beta-D-glucosaminyl-1,3-beta-D-galactosyl-1,4-N-acetyl-D-glucosaminyl-R." [EC:2.4.1.149] synonym: "galbeta1->4GlcNAc-R beta1->3 N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "GnTE activity" EXACT [EC:2.4.1.149] synonym: "N-acetyllactosamine beta(1-3)N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "poly-N-acetyllactosamine extension enzyme activity" BROAD [EC:2.4.1.149] synonym: "UDP-GlcNAc:Galbeta1->4GlcNAcbeta-rbeta1->3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-GlcNAc:GalR, beta-D-3-N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "UDP-N-acetyl-D-glucosamine:beta-D-galactosyl-1,4-N-acetyl-D-glucosamine beta-1,3-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.149] synonym: "uridine diphosphoacetylglucosamine-acetyllactosaminide beta1->3-acetylglucosaminyltransferase" BROAD [EC:2.4.1.149] xref: EC:2.4.1.149 xref: MetaCyc:2.4.1.149-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008533 name: astacin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide bonds in substrates containing five or more amino acids, preferentially with Ala in P1', and Pro in P2'." [EC:3.4.24.21] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Astacus proteinase activity" EXACT [EC:3.4.24.21] synonym: "astacus proteinase activity" NARROW [EC:3.4.24.21] synonym: "crayfish small-molecule proteinase activity" NARROW [EC:3.4.24.21] xref: EC:3.4.24.21 xref: MetaCyc:3.4.24.21-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008534 name: oxidized purine base lesion DNA N-glycosylase activity namespace: molecular_function alt_id: GO:0003907 def: "Catalysis of the removal of oxidized purine bases by cleaving the N-C1' glycosidic bond between the oxidized purine and the deoxyribose sugar. The reaction involves the formation of a covalent enzyme-substrate intermediate. Release of the enzyme and free base by a beta-elimination or a beta, gamma-elimination mechanism results in the cleavage of the DNA backbone 3' of the apurinic (AP) site." [GOC:elh, PMID:11554296] comment: Consider also annotating to the molecular function term 'DNA-(apurinic or apyrimidinic site) lyase activity ; GO:0003906'. subset: gosubset_prok synonym: "2,6-diamino-4-hydroxy-5(N-methyl)formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "2,6-diamino-4-hydroxy-5N-formamidopyrimidine-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "8-oxoguanine DNA glycosylase activity" BROAD [] synonym: "bifunctional DNA glycosylase activity" BROAD [] synonym: "deoxyribonucleate glycosidase activity" EXACT [EC:3.2.2.23] synonym: "DNA glycohydrolase [2,6-diamino-4-hydroxy-5-(N-methyl)formamidopyrimide releasing]" RELATED [EC:3.2.2.23] synonym: "DNA glycosylase/AP-lyase activity" BROAD [] synonym: "DNA glycosylase/beta-lyase activity" BROAD [] synonym: "DNA-formamidopyrimidine glycosylase activity" EXACT [] synonym: "fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "Fapy-DNA glycosylase activity" EXACT [EC:3.2.2.23] synonym: "formamidopyrimidine-DNA glycosylase activity" EXACT [] synonym: "Fpg protein" RELATED [EC:3.2.2.23] synonym: "purine-specific oxidized base lesion DNA N-glycosylase activity" RELATED [] xref: EC:3.2.2.23 xref: MetaCyc:3.2.2.23-RXN xref: Reactome:24932 "oxidized purine base lesion DNA N-glycosylase activity" is_a: GO:0000702 ! oxidized base lesion DNA N-glycosylase activity is_a: GO:0003906 ! DNA-(apurinic or apyrimidinic site) lyase activity [Term] id: GO:0008535 name: respiratory chain complex IV assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form respiratory chain complex IV (also known as cytochrome c oxidase), the terminal member of the respiratory chain of the mitochondrion and some aerobic bacteria. Cytochrome c oxidases are multi-subunit enzymes containing from 13 subunits in the mammalian mitochondrial form to 3-4 subunits in the bacterial forms." [GOC:jl, http://www.med.wright.edu/bmb/lp/lplab.htm] subset: gosubset_prok synonym: "cytochrome c oxidase biogenesis" BROAD [] synonym: "cytochrome c oxidase complex assembly" EXACT [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0008536 name: Ran GTPase binding namespace: molecular_function def: "Interacting selectively and non-covalently with Ran, a conserved Ras-like GTP-binding protein, implicated in nucleocytoplasmic transport, cell cycle progression, spindle assembly, nuclear organization and nuclear envelope (NE) assembly." [GOC:rn, PMID:12787777, PMID:14726649] synonym: "Ran protein binding" EXACT [] synonym: "Ran-binding protein" RELATED [] is_a: GO:0017016 ! Ras GTPase binding [Term] id: GO:0008537 name: proteasome activator complex namespace: cellular_component def: "A multisubunit complex that activates the hydrolysis of small nonubiquitinated peptides by binding to the proteasome core complex." [GOC:rb] synonym: "PA28" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0022624 ! proteasome accessory complex [Term] id: GO:0008538 name: proteasome activator activity namespace: molecular_function def: "OBSOLETE. Catalysis of the activation of the proteasome, a large multisubunit complex which performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:rn, PMID:10428771] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PA28" NARROW [] is_obsolete: true consider: GO:0061133 consider: GO:0061136 [Term] id: GO:0008539 name: proteasome inhibitor activity namespace: molecular_function def: "OBSOLETE. Stops, prevents or reduces the activity of the proteasome complex. The proteasome complex performs regulated ubiquitin-dependent cytosolic and nuclear proteolysis." [GOC:mah] comment: The term was made obsolete because 'proteasome' is not a valid molecular function term. synonym: "PI-31" NARROW [] is_obsolete: true consider: GO:0004866 consider: GO:0061136 [Term] id: GO:0008540 name: proteasome regulatory particle, base subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex." [GOC:mtg_sensu, GOC:rb] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008541 name: proteasome regulatory particle, lid subcomplex namespace: cellular_component def: "The subcomplex of the proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex." [GOC:rb] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part relationship: part_of GO:0005838 ! proteasome regulatory particle [Term] id: GO:0008542 name: visual learning namespace: biological_process def: "Any process in an organism in which a change in behavior of an individual in response to repeated exposure to a visual cue." [GOC:jid, ISBN:0582227089] synonym: "spatial learning" RELATED [] is_a: GO:0007632 ! visual behavior is_a: GO:0008306 ! associative learning [Term] id: GO:0008543 name: fibroblast growth factor receptor signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands." [GOC:ceb] synonym: "FGF receptor signaling pathway" EXACT [] synonym: "FGF receptor signalling pathway" EXACT [] synonym: "FGFR signaling pathway" EXACT [] synonym: "fibroblast growth factor receptor signalling pathway" EXACT [] xref: Reactome:190236 "Signaling by FGFR" xref: Reactome:190239 "FGFR3 ligand binding and activation" xref: Reactome:190241 "FGFR2 ligand binding and activation" xref: Reactome:190242 "FGFR1 ligand binding and activation" xref: Reactome:190322 "FGFR4 ligand binding and activation" xref: Reactome:190370 "FGFR1b ligand binding and activation" xref: Reactome:190371 "FGFR3b ligand binding and activation" xref: Reactome:190372 "FGFR3c ligand binding and activation" xref: Reactome:190373 "FGFR1c ligand binding and activation" xref: Reactome:190374 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:190375 "FGFR2c ligand binding and activation" xref: Reactome:190376 "FGFR ligand binding and activation" xref: Reactome:190377 "FGFR2b ligand binding and activation" xref: Reactome:562675 "Signaling by FGFR" xref: Reactome:562943 "FGFR1b ligand binding and activation" xref: Reactome:562944 "FGFR1 ligand binding and activation" xref: Reactome:562945 "FGFR ligand binding and activation" xref: Reactome:562946 "FGFR1c ligand binding and activation" xref: Reactome:562947 "FGFR2b ligand binding and activation" xref: Reactome:562948 "FGFR2 ligand binding and activation" xref: Reactome:562949 "FGFR2c ligand binding and activation" xref: Reactome:562950 "FGFR3b ligand binding and activation" xref: Reactome:562951 "FGFR3 ligand binding and activation" xref: Reactome:562952 "FGFR3c ligand binding and activation" xref: Reactome:562953 "FGFR4 ligand binding and activation" xref: Reactome:562954 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:588300 "Signaling by FGFR" xref: Reactome:588564 "FGFR1b ligand binding and activation" xref: Reactome:588565 "FGFR1 ligand binding and activation" xref: Reactome:588566 "FGFR ligand binding and activation" xref: Reactome:588567 "FGFR1c ligand binding and activation" xref: Reactome:588568 "FGFR2b ligand binding and activation" xref: Reactome:588569 "FGFR2 ligand binding and activation" xref: Reactome:588570 "FGFR2c ligand binding and activation" xref: Reactome:588571 "FGFR3b ligand binding and activation" xref: Reactome:588572 "FGFR3 ligand binding and activation" xref: Reactome:588573 "FGFR3c ligand binding and activation" xref: Reactome:588574 "FGFR4 ligand binding and activation" xref: Reactome:588575 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:609040 "Signaling by FGFR" xref: Reactome:609304 "FGFR1b ligand binding and activation" xref: Reactome:609305 "FGFR1 ligand binding and activation" xref: Reactome:609306 "FGFR ligand binding and activation" xref: Reactome:609307 "FGFR1c ligand binding and activation" xref: Reactome:609308 "FGFR2b ligand binding and activation" xref: Reactome:609309 "FGFR2 ligand binding and activation" xref: Reactome:609310 "FGFR2c ligand binding and activation" xref: Reactome:609311 "FGFR3b ligand binding and activation" xref: Reactome:609312 "FGFR3 ligand binding and activation" xref: Reactome:609313 "FGFR3c ligand binding and activation" xref: Reactome:609314 "FGFR4 ligand binding and activation" xref: Reactome:609315 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:633733 "Signaling by FGFR" xref: Reactome:633995 "FGFR1b ligand binding and activation" xref: Reactome:633996 "FGFR1 ligand binding and activation" xref: Reactome:633997 "FGFR ligand binding and activation" xref: Reactome:633998 "FGFR1c ligand binding and activation" xref: Reactome:633999 "FGFR2b ligand binding and activation" xref: Reactome:634000 "FGFR2 ligand binding and activation" xref: Reactome:634001 "FGFR2c ligand binding and activation" xref: Reactome:634002 "FGFR3b ligand binding and activation" xref: Reactome:634003 "FGFR3 ligand binding and activation" xref: Reactome:634004 "FGFR3c ligand binding and activation" xref: Reactome:634005 "FGFR4 ligand binding and activation" xref: Reactome:634006 "FGFR1c and Klotho ligand binding and activation" xref: Reactome:645347 "Signaling by FGFR" xref: Reactome:656169 "Signaling by FGFR" is_a: GO:0007169 ! transmembrane receptor protein tyrosine kinase signaling pathway [Term] id: GO:0008544 name: epidermis development namespace: biological_process def: "The process whose specific outcome is the progression of the epidermis over time, from its formation to the mature structure. The epidermis is the outer epithelial layer of a plant or animal, it may be a single layer that produces an extracellular material (e.g. the cuticle of arthropods) or a complex stratified squamous epithelium, as in the case of many vertebrate species." [GOC:go_curators, http://cancerweb.ncl.ac.uk/] synonym: "hypodermis development" RELATED [GOC:kmv, GOC:rk] is_a: GO:0009888 ! tissue development relationship: part_of GO:0007398 ! ectoderm development [Term] id: GO:0008545 name: JUN kinase kinase activity namespace: molecular_function def: "Catalysis of the phosphorylation of tyrosine and threonine residues in a c-Jun NH2-terminal kinase (JNK), a member of a subgroup of mitogen-activated protein kinases (MAPKs), which signal in response to cytokines and exposure to environmental stress. JUN kinase kinase (JNKK) is a dual-specificity protein kinase kinase and requires activation by a serine/threonine kinase JUN kinase kinase kinase." [GOC:bf, PMID:11057897, PMID:11790549] synonym: "JNKK" EXACT [] xref: EC:2.7.11.- xref: Reactome:24962 "JUN kinase kinase activity" is_a: GO:0004708 ! MAP kinase kinase activity [Term] id: GO:0008546 name: microtubule/chromatin interaction namespace: biological_process def: "OBSOLETE. Physical interaction between microtubules and chromatin via DNA binding proteins." [PMID:10322137] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true consider: GO:0003677 consider: GO:0003682 consider: GO:0008017 consider: GO:0030674 [Term] id: GO:0008547 name: protein-synthesizing GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. A GTPase involved in protein synthesis. In the initiation factor complex, it is IF-2b (98 kDa) that binds GTP and subsequently hydrolyzes it in prokaryotes. In eukaryotes, it is eIF-2 (150 kDa) that binds GTP. In the elongation phase, the GTP-hydrolyzing proteins are the EF-Tu polypeptide of the prokaryotic transfer factor (43 kDa), the eukaryotic elongation factor EF-1a (53 kDa), the prokaryotic EF-G (77 kDa), the eukaryotic EF-2 (70-110 kDa) and the signal recognition particle that play a role in endoplasmic reticulum protein synthesis (325 kDa). EF-Tu and EF1a catalyze binding of aminoacyl-tRNA to the ribosomal A-site, while EF-G and EF-2 catalyze the translocation of peptidyl-tRNA from the A-site to the P-site. GTPase activity is also involved in polypeptide release from the ribosome with the aid of the pRFs and eRFs." [EC:3.6.5.3, MetaCyc:3.6.1.48-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0006412 consider: GO:0008135 [Term] id: GO:0008548 name: signal-recognition-particle GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. Activity is associated with the signal-recognition particle, a protein and RNA-containing structure involved in endoplasmic reticulum-associated protein synthesis." [EC:3.6.5.4, MetaCyc:3.6.1.49-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0005786 [Term] id: GO:0008549 name: dynamin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An enzyme that is involved in endocytosis and is instrumental in pinching off membrane vesicles." [EC:3.6.5.5, MetaCyc:3.6.1.50-RXN] comment: This term was made obsolete because it represents a gene product. synonym: "dynamine GTPase activity" EXACT [] is_obsolete: true replaced_by: GO:0003924 consider: GO:0006897 [Term] id: GO:0008550 name: tubulin GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate. An intrinsic activity of alpha-tubulin involved in tubulin folding, division plane formation in prokaryotic cells and others." [EC:3.6.5.6, MetaCyc:3.6.1.51-RXN] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 replaced_by: GO:0007021 [Term] id: GO:0008551 name: cadmium-exporting ATPase activity namespace: molecular_function alt_id: GO:0008561 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cd2+(in) = ADP + phosphate + Cd2+(out)." [EC:3.6.3.3] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cd2+-exporting)" EXACT [EC:3.6.3.3] synonym: "cadmium exporting ATPase activity" EXACT [] synonym: "cadmium-translocating P-type ATPase activity" RELATED [EC:3.6.3.3] synonym: "Cd(2+)-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "Cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] synonym: "cd2+-exporting ATPase activity" EXACT [EC:3.6.3.3] xref: EC:3.6.3.3 xref: MetaCyc:3.6.3.3-RXN is_a: GO:0015086 ! cadmium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008552 name: zinc, cadmium, cobalt, nickel, lead-efflux ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: Me2+(in) + ATP = Me2+(out) + ADP + phosphate, where Me is Zn2+, Cd2+, Co2+, Ni2+ or Pb2+." [TC:3.A.3.6.2] comment: This term was made obsolete because it represents more than one molecular function. is_obsolete: true consider: GO:0005385 consider: GO:0015086 consider: GO:0015087 consider: GO:0015094 consider: GO:0015099 consider: GO:0015662 [Term] id: GO:0008553 name: hydrogen-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) = ADP + phosphate + H+(out); by a phosphorylative mechanism." [EC:3.6.3.6] subset: gosubset_prok synonym: "ATP phosphohydrolase (H+-exporting)" EXACT [EC:3.6.3.6] synonym: "H(+)-exporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H(+)-transporting ATPase activity" BROAD [EC:3.6.3.6] synonym: "H+-exporting ATPase activity" EXACT [EC:3.6.3.6] synonym: "H+-transporting ATPase" BROAD [EC:3.6.3.6] synonym: "hydrogen exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "proton transport ATPase activity" RELATED [EC:3.6.3.6] synonym: "proton-exporting ATPase" RELATED [EC:3.6.3.6] synonym: "proton-translocating ATPase activity" EXACT [EC:3.6.3.6] synonym: "proton-translocating P-type ATPase activity" EXACT [EC:3.6.3.6] synonym: "yeast plasma membrane ATPase" NARROW [EC:3.6.3.6] synonym: "yeast plasma membrane H+-ATPase" NARROW [EC:3.6.3.6] xref: EC:3.6.3.6 xref: MetaCyc:3.6.3.6-RXN is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008554 name: sodium-exporting ATPase activity, phosphorylative mechanism namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) = ADP + phosphate + Na+(out); by a phosphorylative mechanism." [EC:3.6.3.7] subset: gosubset_prok synonym: "ATP phosphohydrolase (Na+-exporting)" EXACT [EC:3.6.3.7] synonym: "hydrogen-/sodium-translocating ATPase activity" RELATED [] synonym: "Na(+)-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na(+)-transporting ATPase activity" BROAD [EC:3.6.3.7] synonym: "Na+-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "Na+-transporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium exporting ATPase activity, phosphorylative mechanism" EXACT [] synonym: "sodium transport ATPase activity" RELATED [EC:3.6.3.7] synonym: "sodium-exporting ATPase activity" EXACT [EC:3.6.3.7] synonym: "sodium-translocating P-type ATPase activity" RELATED [EC:3.6.3.7] xref: EC:3.6.3.7 xref: MetaCyc:3.6.3.7-RXN is_a: GO:0015081 ! sodium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008555 name: chloride-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Cl-(out) = ADP + phosphate + Cl-(in)." [EC:3.6.3.11] subset: gosubset_prok synonym: "ATP phosphohydrolase (Cl--importing)" EXACT [EC:3.6.3.11] synonym: "chloride ABC transporter" NARROW [] synonym: "chloride transporting ATPase activity" EXACT [] synonym: "chloride-motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "chloride-translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl(-)-transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--motive ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--translocating ATPase activity" EXACT [EC:3.6.3.11] synonym: "Cl--transporting ATPase activity" EXACT [EC:3.6.3.11] synonym: "cl--transporting ATPase activity" EXACT [EC:3.6.3.11] xref: EC:3.6.3.11 xref: MetaCyc:3.6.3.11-RXN is_a: GO:0015108 ! chloride transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008556 name: potassium-transporting ATPase activity namespace: molecular_function alt_id: GO:0015618 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in)." [EC:3.6.3.12] subset: gosubset_prok synonym: "ATP phosphohydrolase (K+-importing)" EXACT [EC:3.6.3.12] synonym: "K(+)-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "K(+)-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-importing ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-translocating Kdp-ATPase activity" EXACT [EC:3.6.3.12] synonym: "K+-transporting ATPase activity" EXACT [] synonym: "k+-transporting ATPase activity" EXACT [EC:3.6.3.12] synonym: "multi-subunit K+-transport ATPase" NARROW [EC:3.6.3.12] synonym: "potassium ABC transporter" NARROW [] synonym: "potassium transporting ATPase activity" EXACT [] synonym: "potassium-importing ATPase activity" NARROW [EC:3.6.3.12] synonym: "potassium-uptake-ATPase activity" EXACT [] xref: EC:3.6.3.12 is_a: GO:0015079 ! potassium ion transmembrane transporter activity is_a: GO:0015662 ! ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism [Term] id: GO:0008558 name: guanine-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + guanine(out) = ADP + phosphate + guanine(in)." [EC:3.6.3.37] synonym: "ATP phosphohydrolase (guanine-importing)" EXACT [EC:3.6.3.37] synonym: "guanine ABC transporter" NARROW [] xref: EC:3.6.3.37 xref: MetaCyc:3.6.3.37-RXN is_a: GO:0015208 ! guanine transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances [Term] id: GO:0008559 name: xenobiotic-transporting ATPase activity namespace: molecular_function alt_id: GO:0005226 alt_id: GO:0008560 def: "Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out)." [EC:3.6.3.44] subset: gosubset_prok synonym: "ATP phosphohydrolase (steroid-exporting)" EXACT [EC:3.6.3.44] synonym: "ATP phosphohydrolase (xenobiotic-exporting)" EXACT [EC:3.6.3.44] synonym: "MDR protein" RELATED [EC:3.6.3.44] synonym: "multidrug resistance exporter" RELATED [] synonym: "multidrug-resistance protein" RELATED [] synonym: "P-glycoprotein" RELATED [] synonym: "PDR protein" RELATED [EC:3.6.3.44] synonym: "pleiotropic-drug-resistance protein" RELATED [EC:3.6.3.44] synonym: "steroid ABC transporter" NARROW [] synonym: "steroid-transporting ATPase activity" EXACT [] synonym: "xenobiotic ABC transporter" NARROW [] xref: EC:3.6.3.44 xref: MetaCyc:3.6.3.44-RXN is_a: GO:0015238 ! drug transmembrane transporter activity is_a: GO:0042626 ! ATPase activity, coupled to transmembrane movement of substances is_a: GO:0042910 ! xenobiotic transporter activity [Term] id: GO:0008563 name: alpha-factor sex pheromone exporter namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O + alpha-factor(in) = ADP + phosphate + alpha-factor(out). The export of the alpha-factor sex pheromone by an ABC-type (ATP-binding cassette-type) ATPase, characterized by the presence of two similar ATP-binding domains, that does not undergo phosphorylation during the transport process." [EC:3.6.3.48] comment: This term was made obsolete because this function does not exist; alpha-factor is secreted by the classical secretion pathway and not exported. synonym: "alpha-factor-transporting ATPase" RELATED [] is_obsolete: true [Term] id: GO:0008564 name: protein-exporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the concomitant secretion of proteins." [EC:3.6.3.50] synonym: "ATP phosphohydrolase (protein-secreting)" EXACT [EC:3.6.3.50] synonym: "protein-secreting ATPase activity" EXACT [] xref: EC:3.6.3.50 xref: MetaCyc:3.6.3.50-RXN is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity [Term] id: GO:0008565 name: protein transporter activity namespace: molecular_function alt_id: GO:0015463 def: "Enables the directed movement of proteins into, out of, within or between cells." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_goa subset: gosubset_prok synonym: "enzyme transporter activity" NARROW [] synonym: "holin" RELATED [] synonym: "protein carrier activity" EXACT [] synonym: "protein transport chaperone" NARROW [GOC:dph, GOC:mah, GOC:tb] synonym: "secretin" RELATED [] is_a: GO:0022892 ! substrate-specific transporter activity relationship: part_of GO:0015031 ! protein transport [Term] id: GO:0008566 name: mitochondrial protein-transporting ATPase activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O = ADP + phosphate; drives the transport of proteins into the mitochondrion via the mitochondrial inner membrane translocase complex." [EC:3.6.3.51] comment: See also the cellular component term 'mitochondrial inner membrane presequence translocase complex ; GO:0005744'. synonym: "ATP phosphohydrolase (mitochondrial protein-importing) activity" EXACT [EC:3.6.3.51] xref: EC:3.6.3.51 xref: MetaCyc:3.6.3.51-RXN is_a: GO:0015462 ! protein-transmembrane transporting ATPase activity [Term] id: GO:0008567 name: dynein ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by dynein that provides the energy for the movement of organelles (endosomes, lysosomes, mitochondria) along microtubules to the centrosome." [EC:3.6.4.2] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true consider: GO:0003777 consider: GO:0007018 [Term] id: GO:0008568 name: microtubule-severing ATPase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + H2O = ADP + phosphate. Catalysis of the severing of a microtubule at a specific spot along its length, coupled to the hydrolysis of ATP." [EC:3.6.4.3, PMID:10910766] comment: See also the cellular component term 'katanin complex ; GO:0008352'. synonym: "ATP phosphohydrolase (tubulin-dimerizing)" EXACT [EC:3.6.4.3] synonym: "katanin activity" NARROW [EC:3.6.4.3] xref: EC:3.6.4.3 xref: MetaCyc:3.6.4.3-RXN is_a: GO:0042623 ! ATPase activity, coupled [Term] id: GO:0008569 name: minus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the minus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.5, GOC:mah] synonym: "kinesin ATP phosphohydrolase (minus-end-directed)" EXACT [EC:3.6.4.5] synonym: "minus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.5 xref: MetaCyc:3.6.4.5-RXN is_a: GO:0003777 ! microtubule motor activity [Term] id: GO:0008570 name: myosin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by myosin that provides the energy for actomyosin contraction." [EC:3.6.4.1] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true replaced_by: GO:0000146 consider: GO:0030048 [Term] id: GO:0008571 name: non-chaperonin molecular chaperone ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. This is a highly diverse group of enzymes that perform many functions that are similar to those of chaperonins. They comprise a number of heat-shock-cognate proteins. They are also active in clathrin uncoating and in the oligomerization of actin." [EC:3.6.4.10] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006457 [Term] id: GO:0008572 name: nucleoplasmin ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP required for the ATP-dependent assembly of nucleosome cores, in decondensation of sperm chromatin and in other histone-involving processes." [EC:3.6.4.11] comment: This term was made obsolete because it represents a class of gene products, and its definition incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006333 [Term] id: GO:0008573 name: peroxisome-assembly ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. ATP hydrolysis to import and assemble peroxisome components into the organelle." [EC:3.6.4.7] comment: This term was made obsolete because it incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0007031 [Term] id: GO:0008574 name: plus-end-directed microtubule motor activity namespace: molecular_function def: "Catalysis of movement along a microtubule toward the plus end, coupled to the hydrolysis of ATP (or GTP)." [EC:3.6.4.4] synonym: "kinesin activity" RELATED [EC:3.6.4.4] synonym: "kinesin ATP phosphohydrolase (plus-end-directed)" EXACT [EC:3.6.4.4] synonym: "plus-end-directed kinesin ATPase activity" BROAD [] xref: EC:3.6.4.4 xref: MetaCyc:3.6.4.4-RXN is_a: GO:0003777 ! microtubule motor activity [Term] id: GO:0008575 name: proteasome ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP for channel gating and polypeptide unfolding before proteolysis in the proteasome. Six ATPase subunits are present in the regulatory particle (RP) of 26S proteasome." [EC:3.6.4.8] comment: This term was made obsolete because it mentions a component term in the term text string. is_obsolete: true consider: GO:0016887 [Term] id: GO:0008576 name: vesicle-fusing ATPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: ATP + H2O = ADP + phosphate. The hydrolysis of ATP by an AAA-ATPase, involved in the heterotypic fusion of membrane vesicles with target membranes and the homotypic fusion of various membrane compartments." [EC:3.6.4.6] comment: This term was made obsolete because it incorporates process information. is_obsolete: true replaced_by: GO:0042623 consider: GO:0006944 consider: GO:0016192 [Term] id: GO:0008579 name: JUN kinase phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: JUN kinase serine/threonine/tyrosine phosphate + H2O = JUN kinase serine/threonine/tyrosine + phosphate." [GOC:mah] xref: EC:3.1.3.- is_a: GO:0008138 ! protein tyrosine/serine/threonine phosphatase activity [Term] id: GO:0008580 name: cytoskeletal regulator activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because 'cytoskeleton' is not an activity, and regulation of its distribution or modification belongs in the process ontology. is_obsolete: true consider: GO:0007010 [Term] id: GO:0008581 name: ubiquitin-specific protease 5 activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of the Gly76-Lys48 isopeptide bond of polyubiquitin." [ISBN:0120793709, MEROPS:c19p001] comment: This term was made obsolete because it represents a gene product. synonym: "ubiquitin isopeptidase T activity" EXACT [] is_obsolete: true replaced_by: GO:0004221 [Term] id: GO:0008582 name: regulation of synaptic growth at neuromuscular junction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of synaptic growth at neuromuscular junctions." [GOC:go_curators] is_a: GO:0048638 ! regulation of developmental growth is_a: GO:0048742 ! regulation of skeletal muscle fiber development is_a: GO:0051963 ! regulation of synaptogenesis intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0051124 ! synaptic growth at neuromuscular junction relationship: regulates GO:0051124 ! synaptic growth at neuromuscular junction [Term] id: GO:0008583 name: mystery cell fate differentiation namespace: biological_process def: "The process by which an undifferentiated cell acquires the features of a mystery cell. The mystery cells are a precluster of cells that emerge from the compound eye morphogenetic furrow, normally positioned between R3 and R4. They then disappear into the surrounding pool of undifferentiated cells and have no known fate in the mature ommatidium. An example of this process is found in Drosophila melanogaster." [ISBN:0632030488, PMID:1295747] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0001745 ! compound eye morphogenesis [Term] id: GO:0008584 name: male gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the male gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "testicular development" EXACT [GOC:sl] synonym: "testis development" EXACT [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046546 ! development of primary male sexual characteristics [Term] id: GO:0008585 name: female gonad development namespace: biological_process def: "The process whose specific outcome is the progression of the female gonad over time, from its formation to the mature structure." [GOC:jid] synonym: "ovarian development" EXACT [GOC:sl] synonym: "ovary development" EXACT [GOC:sl] is_a: GO:0008406 ! gonad development relationship: part_of GO:0046545 ! development of primary female sexual characteristics [Term] id: GO:0008586 name: imaginal disc-derived wing vein morphogenesis namespace: biological_process def: "The process by which anatomical structures of the veins on an imaginal disc-derived wing are generated and organized. Morphogenesis pertains to the creation of form." [GOC:mtg_sensu] synonym: "wing vein morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008587 name: imaginal disc-derived wing margin morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the imaginal disc-derived wing margin are generated and organized. Morphogenesis pertains to the creation of form. The wing margin is a strip of cells in the third instar disc at the boundary between the presumptive dorsal and ventral surfaces of the wing blade." [GOC:bf, GOC:mtg_sensu, ISBN:0879694238] comment: See also the fly_anatomy.ontology term 'wing margin ; FBbt:00005378'. synonym: "wing margin morphogenesis" EXACT [] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0007476 ! imaginal disc-derived wing morphogenesis [Term] id: GO:0008588 name: release of cytoplasmic sequestered NF-kappaB namespace: biological_process def: "The release of NF-kappaB from specific molecules in the cytoplasm to which it was bound, thereby allowing its translocation into the nucleus." [GOC:jl] synonym: "activation of NF-kappa B" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB retention" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB sequestering" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB sequestration" RELATED [] synonym: "negative regulation of cytoplasmic NF-kappaB storage" RELATED [] synonym: "release of NF-kappaB sequestered in cytoplasm" EXACT [] synonym: "release of NF-kappaB stored in cytoplasm" EXACT [] is_a: GO:0042346 ! positive regulation of NF-kappaB import into nucleus relationship: part_of GO:0007249 ! I-kappaB kinase/NF-kappaB cascade [Term] id: GO:0008589 name: regulation of smoothened signaling pathway namespace: biological_process alt_id: GO:0007226 alt_id: GO:0043109 def: "Any process that modulates the frequency, rate or extent of smoothened signaling." [GOC:go_curators] synonym: "regulation of hedgehog signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of hh signaling pathway" EXACT [GOC:bf, GOC:ecd] synonym: "regulation of smoothened activity" RELATED [] synonym: "regulation of smoothened by patched" RELATED [] synonym: "regulation of smoothened receptor activity by patched" RELATED [] synonym: "regulation of smoothened signalling pathway" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007224 ! smoothened signaling pathway relationship: regulates GO:0007224 ! smoothened signaling pathway [Term] id: GO:0008591 name: regulation of Wnt receptor signaling pathway, calcium modulating pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors leads to an increase in intracellular calcium and activation of protein kinase C (PKC)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "regulation of frizzled-2 signaling pathway" EXACT [] synonym: "regulation of frizzled-2 signalling pathway" EXACT [] is_a: GO:0030111 ! regulation of Wnt receptor signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway relationship: regulates GO:0007223 ! Wnt receptor signaling pathway, calcium modulating pathway [Term] id: GO:0008592 name: regulation of Toll signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Tl signaling pathway." [GOC:go_curators] synonym: "regulation of Tl signaling pathway" EXACT [] synonym: "regulation of Tl signalling pathway" EXACT [] synonym: "regulation of Toll signalling pathway" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008063 ! Toll signaling pathway relationship: regulates GO:0008063 ! Toll signaling pathway [Term] id: GO:0008593 name: regulation of Notch signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the Notch signaling pathway." [GOC:go_curators] synonym: "regulation of N signaling pathway" EXACT [] synonym: "regulation of N signalling pathway" EXACT [] synonym: "regulation of Notch signalling pathway" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007219 ! Notch signaling pathway relationship: regulates GO:0007219 ! Notch signaling pathway [Term] id: GO:0008594 name: photoreceptor cell morphogenesis namespace: biological_process def: "The process by which the structures of a photoreceptor cell are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a photoreceptor cell, a sensory cell that reacts to the presence of light. An example of this is found in Drosophila melanogaster." [GOC:jid, GOC:mah] synonym: "photoreceptor development" RELATED [] is_a: GO:0048667 ! cell morphogenesis involved in neuron differentiation relationship: part_of GO:0042461 ! photoreceptor cell development [Term] id: GO:0008595 name: anterior/posterior axis specification, embryo namespace: biological_process def: "The specification of the anterior/posterior axis of the embryo by the products of genes expressed maternally and genes expressed in the zygote." [http://fly.ebi.ac.uk/allied-data/lk/interactive-fly/aimain/1aahome.htm, ISBN:0879694238] synonym: "anterior/posterior axis determination, embryo" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0009948 ! anterior/posterior axis specification relationship: part_of GO:0007351 ! tripartite regional subdivision [Term] id: GO:0008597 name: calcium-dependent protein serine/threonine phosphatase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme calcium-dependent protein serine/threonine phosphatase." [EC:3.1.3.16, GOC:ai] synonym: "calcium-dependent protein serine/threonine phosphatase, intrinsic regulator activity" NARROW [] xref: Reactome:25079 "calcium-dependent protein serine/threonine phosphatase regulator activity" is_a: GO:0019888 ! protein phosphatase regulator activity relationship: regulates GO:0004723 ! calcium-dependent protein serine/threonine phosphatase activity [Term] id: GO:0008599 name: protein phosphatase type 1 regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 1." [GOC:ai] synonym: "protein phosphatase type 1, intrinsic regulator activity" NARROW [] xref: Reactome:25081 "protein phosphatase type 1 regulator activity" is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008601 name: protein phosphatase type 2A regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme protein phosphatase type 2A." [GOC:ai] synonym: "protein phosphatase type 2A, intrinsic regulator activity" NARROW [] is_a: GO:0019888 ! protein phosphatase regulator activity [Term] id: GO:0008603 name: cAMP-dependent protein kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme cAMP-dependent protein kinase." [GOC:ai] subset: gosubset_prok synonym: "3',5' cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "3',5'-cAMP-dependent protein kinase regulator activity" EXACT [] synonym: "adenosine 3',5'-cyclophosphate-dependent protein kinase regulator activity" EXACT [] synonym: "cAMP-dependent protein kinase, intrinsic regulator activity" NARROW [] synonym: "cyclic AMP-dependent protein kinase regulator activity" EXACT [] is_a: GO:0019887 ! protein kinase regulator activity relationship: regulates GO:0004691 ! cAMP-dependent protein kinase activity [Term] id: GO:0008605 name: protein kinase CK2 regulator activity namespace: molecular_function def: "OBSOLETE. Modulation of the activity of the enzyme protein kinase CK2." [GOC:ai] comment: This term was made obsolete because it represents a regulator of an obsolete molecular function. synonym: "casein kinase II, regulator" EXACT [] synonym: "protein kinase CK2, intrinsic regulator activity" NARROW [] is_obsolete: true replaced_by: GO:0019887 [Term] id: GO:0008607 name: phosphorylase kinase regulator activity namespace: molecular_function def: "Modulation of the activity of the enzyme phosphorylase kinase." [EC:2.7.11.19] synonym: "phosphorylase kinase, intrinsic regulator activity" NARROW [] xref: EC:2.7.1.- is_a: GO:0019887 ! protein kinase regulator activity relationship: regulates GO:0004689 ! phosphorylase kinase activity [Term] id: GO:0008608 name: attachment of spindle microtubules to kinetochore namespace: biological_process def: "The process by which spindle microtubules become physically associated with the proteins making up the kinetochore complex." [GOC:vw, PMID:10322137] synonym: "amphotelic attachment" RELATED [] synonym: "bipolar attachment" RELATED [] synonym: "correction of merotelic attachment" NARROW [] synonym: "kinetochore microtubule interaction" BROAD [] synonym: "kinetochore-microtubule attachment" EXACT [GOC:ascb_2009, GOC:dph, GOC:tb] synonym: "kinetochore-microtubule interaction" BROAD [] synonym: "microtubule anchoring at kinetochore" EXACT [] synonym: "microtubule and kinetochore interaction" RELATED [] synonym: "microtubule capture" NARROW [] synonym: "prevention of merotelic attachment" NARROW [] synonym: "spindle kinetochore attachment" EXACT [] is_a: GO:0051313 ! attachment of spindle microtubules to chromosome [Term] id: GO:0008609 name: alkylglycerone-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 1-acyl-glycerone 3-phosphate + a long-chain alcohol = 1-alkyl-glycerone 3-phosphate + a long-chain acid anion." [EC:2.5.1.26] subset: gosubset_prok synonym: "1-acyl-glycerone-3-phosphate:long-chain-alcohol O-3-phospho-2-oxopropanyltransferase activity" EXACT [EC:2.5.1.26] synonym: "alkyl DHAP synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyl-DHAP" RELATED [EC:2.5.1.26] synonym: "alkyl-DHAP synthase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetone phosphate synthetase activity" EXACT [EC:2.5.1.26] synonym: "alkyldihydroxyacetonephosphate synthase activity" EXACT [EC:2.5.1.26] synonym: "DHAP-AT" RELATED [EC:2.5.1.26] synonym: "dihydroxyacetone-phosphate acyltransferase activity" EXACT [EC:2.5.1.26] xref: EC:2.5.1.26 xref: MetaCyc:ALKYLGLYCERONE-PHOSPHATE-SYNTHASE-RXN xref: Reactome:25371 "alkylglycerone-phosphate synthase activity" is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008610 name: lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent." [GOC:go_curators] subset: gosubset_prok synonym: "lipid anabolism" EXACT [] synonym: "lipid biosynthesis" EXACT [] synonym: "lipid formation" EXACT [] synonym: "lipid synthesis" EXACT [] synonym: "lipogenesis" EXACT [GOC:sl] is_a: GO:0006629 ! lipid metabolic process is_a: GO:0009058 ! biosynthetic process [Term] id: GO:0008611 name: ether lipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol." [GOC:ma, ISBN:0198547684, PMID:15337120] subset: gosubset_prok synonym: "ether lipid anabolism" EXACT [] synonym: "ether lipid biosynthesis" EXACT [] synonym: "ether lipid formation" EXACT [] synonym: "ether lipid synthesis" EXACT [] synonym: "plasmalogen biosynthetic process" NARROW [] xref: Reactome:562564 "Plasmalogen biosynthesis" xref: Reactome:588190 "Plasmalogen biosynthesis" xref: Reactome:608958 "Plasmalogen biosynthesis" xref: Reactome:633640 "Plasmalogen biosynthesis" xref: Reactome:645268 "Plasmalogen biosynthesis" xref: Reactome:655647 "Plasmalogen biosynthesis" xref: Reactome:689677 "Plasmalogen biosynthesis" xref: Reactome:701831 "Plasmalogen biosynthesis" xref: Reactome:716406 "Plasmalogen biosynthesis" xref: Reactome:728359 "Plasmalogen biosynthesis" xref: Reactome:735542 "Plasmalogen biosynthesis" xref: Reactome:738453 "Plasmalogen biosynthesis" xref: Reactome:75896 "Plasmalogen biosynthesis" is_a: GO:0045017 ! glycerolipid biosynthetic process is_a: GO:0046485 ! ether lipid metabolic process is_a: GO:0046504 ! glycerol ether biosynthetic process [Term] id: GO:0008612 name: peptidyl-lysine modification to hypusine namespace: biological_process alt_id: GO:0046515 def: "The posttranslational modification of peptidyl-lysine to form hypusine, N6-(4-amino-2-hydroxybutyl)-L-lysine." [GOC:ma, ISBN:0198547684, RESID:AA0116] subset: gosubset_prok synonym: "hypusine anabolism" EXACT [] synonym: "hypusine anabolism from peptidyl-lysine" EXACT [] synonym: "hypusine biosynthesis" EXACT [] synonym: "hypusine biosynthetic process" EXACT [] synonym: "hypusine biosynthetic process from peptidyl-lysine" EXACT [] synonym: "hypusine formation" EXACT [] synonym: "hypusine formation from peptidyl-lysine" EXACT [] synonym: "hypusine synthesis" EXACT [] synonym: "hypusine synthesis from peptidyl-lysine" EXACT [] xref: Reactome:204626 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:563148 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:588759 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:609484 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:634191 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:645693 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:656022 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:661207 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:666981 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:673122 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:678818 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:683749 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:689970 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:701745 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:716321 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:720824 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:728264 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:731095 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:733099 "Hypusine synthesis from eIF5A-lysine" xref: Reactome:733917 "Hypusine synthesis from eIF5A-lysine" xref: RESID:AA0116 is_a: GO:0018205 ! peptidyl-lysine modification is_a: GO:0046516 ! hypusine metabolic process [Term] id: GO:0008613 name: diuretic hormone activity namespace: molecular_function def: "The action characteristic of a diuretic hormone, any peptide hormone that, upon receptor binding, regulates water balance and fluid secretion." [GOC:mah, InterPro:IPR003621, PMID:8618894] is_a: GO:0005179 ! hormone activity [Term] id: GO:0008614 name: pyridoxine metabolic process namespace: biological_process alt_id: GO:0006773 def: "The chemical reactions and pathways involving pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "pyridoxine metabolism" EXACT [] is_a: GO:0042816 ! vitamin B6 metabolic process [Term] id: GO:0008615 name: pyridoxine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, one of the vitamin B6 compounds." [GOC:ai] subset: gosubset_prok synonym: "pyridoxine anabolism" EXACT [] synonym: "pyridoxine biosynthesis" EXACT [] synonym: "pyridoxine formation" EXACT [] synonym: "pyridoxine synthesis" EXACT [] xref: MetaCyc:PYRIDOXSYN-PWY is_a: GO:0008614 ! pyridoxine metabolic process is_a: GO:0042819 ! vitamin B6 biosynthetic process [Term] id: GO:0008616 name: queuosine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of queuosines, any of a series of nucleosides found in tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "queuosine anabolism" EXACT [] synonym: "queuosine biosynthesis" EXACT [] synonym: "queuosine formation" EXACT [] synonym: "queuosine synthesis" EXACT [] is_a: GO:0006400 ! tRNA modification is_a: GO:0046116 ! queuosine metabolic process is_a: GO:0046118 ! 7-methylguanosine biosynthetic process [Term] id: GO:0008617 name: guanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving guanine, guanine riboside, a nucleoside with a wide species distribution." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "guanosine metabolism" EXACT [] is_a: GO:0046128 ! purine ribonucleoside metabolic process [Term] id: GO:0008618 name: 7-methylguanosine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 7-methylguanosine, a modified nucleoside that forms a cap at the 5'-terminus of eukaryotic mRNA." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "7-methylguanosine metabolism" EXACT [] is_a: GO:0008617 ! guanosine metabolic process [Term] id: GO:0008619 name: RHEB small monomeric GTPase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: GTP + H2O = GDP + phosphate." [EC:3.6.1.47, PMID:12893813] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003924 consider: GO:0001558 consider: GO:0051726 [Term] id: GO:0008622 name: epsilon DNA polymerase complex namespace: cellular_component def: "A heterotetrameric DNA polymerase complex that catalyzes processive DNA synthesis in the absence of PCNA, but is further stimulated in the presence of PCNA. The complex contains a large catalytic subunit and three small subunits, and is best characterized in Saccharomyces, in which the subunits are named Pol2p, Dpb2p, Dpb3p, and Dpb4p. Some evidence suggests that DNA polymerase epsilon is the leading strand polymerase; it is also involved in nucleotide-excision repair and mismatch repair." [PMID:15814431, PMID:9745046] synonym: "DNA polymerase epsilon complex" EXACT [CORUM:420] is_a: GO:0042575 ! DNA polymerase complex is_a: GO:0044454 ! nuclear chromosome part relationship: part_of GO:0000109 ! nucleotide-excision repair complex relationship: part_of GO:0043601 ! nuclear replisome [Term] id: GO:0008623 name: chromatin accessibility complex namespace: cellular_component alt_id: GO:0016588 def: "A multisubunit complex that uses ATP to increase the general accessibility of DNA in chromatin. Unlike other known chromatin remodeling complexes, CHRAC can also function during chromatin assembly; it uses ATP to convert irregular chromatin into a regular array of nucleosomes with even spacing." [GOC:bf, PMID:9252192] synonym: "CHRAC" EXACT [] synonym: "ISW2 complex" NARROW [] is_a: GO:0016585 ! chromatin remodeling complex [Term] id: GO:0008624 name: induction of apoptosis by extracellular signals namespace: biological_process def: "Any process induced by extracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] xref: Reactome:109607 "Extrinsic Pathway for Apoptosis" xref: Reactome:193681 "Ceramide signalling" xref: Reactome:204998 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:549970 "FASL binds FAS Receptor" xref: Reactome:562575 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:563173 "Extrinsic Pathway for Apoptosis" xref: Reactome:563174 "FasL/ CD95L signaling" xref: Reactome:563175 "Death Receptor Signalling" xref: Reactome:563355 "Ceramide signalling" xref: Reactome:576677 "FASL binds FAS Receptor" xref: Reactome:588201 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:588782 "Extrinsic Pathway for Apoptosis" xref: Reactome:588783 "FasL/ CD95L signaling" xref: Reactome:588784 "Death Receptor Signalling" xref: Reactome:588972 "Ceramide signalling" xref: Reactome:599786 "FASL binds FAS Receptor" xref: Reactome:609168 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:609510 "Extrinsic Pathway for Apoptosis" xref: Reactome:609511 "FasL/ CD95L signaling" xref: Reactome:609512 "Death Receptor Signalling" xref: Reactome:609695 "Ceramide signalling" xref: Reactome:633862 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:634222 "Extrinsic Pathway for Apoptosis" xref: Reactome:634384 "Ceramide signalling" xref: Reactome:634430 "Death Receptor Signalling" xref: Reactome:645446 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:645853 "Ceramide signalling" xref: Reactome:655809 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:656170 "Ceramide signalling" xref: Reactome:661287 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:661314 "Ceramide signalling" xref: Reactome:667090 "Ceramide signalling" xref: Reactome:673213 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:673240 "Ceramide signalling" xref: Reactome:678924 "Ceramide signalling" xref: Reactome:701829 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:716404 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:720895 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:728357 "Cell death signalling via NRAGE, NRIF and NADE" xref: Reactome:73887 "Death Receptor Signalling" xref: Reactome:75157 "FasL/ CD95L signaling" xref: Reactome:75244 "FASL binds FAS Receptor" is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0008625 name: induction of apoptosis via death domain receptors namespace: biological_process is_a: GO:0008624 ! induction of apoptosis by extracellular signals [Term] id: GO:0008626 name: induction of apoptosis by granzyme namespace: biological_process is_a: GO:0008624 ! induction of apoptosis by extracellular signals [Term] id: GO:0008627 name: induction of apoptosis by ionic changes namespace: biological_process is_a: GO:0008624 ! induction of apoptosis by extracellular signals [Term] id: GO:0008628 name: induction of apoptosis by hormones namespace: biological_process def: "Any process induced by hormones that directly activates any of the steps required for cell death by apoptosis." [GOC:bf] is_a: GO:0008624 ! induction of apoptosis by extracellular signals is_a: GO:0035081 ! induction of programmed cell death by hormones [Term] id: GO:0008629 name: induction of apoptosis by intracellular signals namespace: biological_process def: "Any process induced by intracellular signals that directly activates any of the steps required for cell death by apoptosis." [GOC:ai] xref: Reactome:109606 "Intrinsic Pathway for Apoptosis" xref: Reactome:562735 "Intrinsic Pathway for Apoptosis" xref: Reactome:588355 "Intrinsic Pathway for Apoptosis" xref: Reactome:609328 "Intrinsic Pathway for Apoptosis" xref: Reactome:633793 "Intrinsic Pathway for Apoptosis" xref: Reactome:645868 "Intrinsic Pathway for Apoptosis" xref: Reactome:656185 "Intrinsic Pathway for Apoptosis" xref: Reactome:661329 "Intrinsic Pathway for Apoptosis" xref: Reactome:667108 "Intrinsic Pathway for Apoptosis" xref: Reactome:673255 "Intrinsic Pathway for Apoptosis" xref: Reactome:678941 "Intrinsic Pathway for Apoptosis" xref: Reactome:683863 "Intrinsic Pathway for Apoptosis" xref: Reactome:690115 "Intrinsic Pathway for Apoptosis" xref: Reactome:701860 "Intrinsic Pathway for Apoptosis" xref: Reactome:716434 "Intrinsic Pathway for Apoptosis" xref: Reactome:728391 "Intrinsic Pathway for Apoptosis" xref: Reactome:731176 "Intrinsic Pathway for Apoptosis" is_a: GO:0006917 ! induction of apoptosis [Term] id: GO:0008630 name: DNA damage response, signal transduction resulting in induction of apoptosis namespace: biological_process def: "A cascade of processes initiated by the detection of DNA damage and resulting in the induction of apoptosis (programmed cell death)." [GOC:go_curators] is_a: GO:0008629 ! induction of apoptosis by intracellular signals is_a: GO:0042770 ! DNA damage response, signal transduction [Term] id: GO:0008631 name: induction of apoptosis by oxidative stress namespace: biological_process def: "The activation, by oxidative stress, of any of the steps required for cell death by apoptosis." [GOC:ai] is_a: GO:0008629 ! induction of apoptosis by intracellular signals [Term] id: GO:0008633 name: activation of pro-apoptotic gene products namespace: biological_process def: "The conversion of proteins that induce or sustain apoptosis to an active form." [GOC:mah] synonym: "induction of pro-apoptotic gene products" RELATED [] xref: Reactome:111446 "Activation of BIM and translocation to mitochondria" xref: Reactome:111447 "Activation of BAD and translocation to mitochondria" xref: Reactome:111448 "Activation of NOXA and translocation to mitochondria" xref: Reactome:111452 "Activation and oligomerization of BAK protein" xref: Reactome:114294 "Activation, translocation and oligomerization of BAX" xref: Reactome:114452 "Activation of BH3-only proteins" xref: Reactome:139893 "Granzyme-B activates BID by cleavage" xref: Reactome:139895 "tBID activates BAK protein" xref: Reactome:139898 "Caspase-8 activates BID by cleavage" xref: Reactome:139910 "Activation of BMF and translocation to mitochondria" xref: Reactome:139915 "Activation of PUMA and translocation to mitochondria" xref: Reactome:140534 "Caspase-8 is formed from procaspase-8" xref: Reactome:544745 "Caspase-8 activates BID by cleavage" xref: Reactome:552747 "Granzyme-B activates BID by cleavage" xref: Reactome:560990 "tBID activates BAK protein" xref: Reactome:562733 "Activation of BAD and translocation to mitochondria" xref: Reactome:562734 "Activation of BH3-only proteins" xref: Reactome:563020 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:563172 "Caspase-8 is formed from procaspase-8" xref: Reactome:563312 "Activation and oligomerization of BAK protein" xref: Reactome:563313 "Activation, translocation and oligomerization of BAX" xref: Reactome:563342 "Activation of BIM and translocation to mitochondria" xref: Reactome:563343 "Activation of BMF and translocation to mitochondria" xref: Reactome:563392 "Activation of PUMA and translocation to mitochondria" xref: Reactome:571837 "Caspase-8 activates BID by cleavage" xref: Reactome:578568 "Granzyme-B activates BID by cleavage" xref: Reactome:586740 "tBID activates BAK protein" xref: Reactome:588353 "Activation of BAD and translocation to mitochondria" xref: Reactome:588354 "Activation of BH3-only proteins" xref: Reactome:588638 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:588781 "Caspase-8 is formed from procaspase-8" xref: Reactome:588927 "Activation and oligomerization of BAK protein" xref: Reactome:588928 "Activation, translocation and oligomerization of BAX" xref: Reactome:588957 "Activation of BIM and translocation to mitochondria" xref: Reactome:588958 "Activation of BMF and translocation to mitochondria" xref: Reactome:595980 "Caspase-8 activates BID by cleavage" xref: Reactome:601732 "Granzyme-B activates BID by cleavage" xref: Reactome:607713 "tBID activates BAK protein" xref: Reactome:609373 "Activation, myristolyation of BID and translocation to mitochondria" xref: Reactome:609509 "Caspase-8 is formed from procaspase-8" xref: Reactome:609646 "Activation and oligomerization of BAK protein" xref: Reactome:609679 "Activation of BMF and translocation to mitochondria" xref: Reactome:609680 "Activation of BH3-only proteins" xref: Reactome:633791 "Activation of BAD and translocation to mitochondria" xref: Reactome:633792 "Activation of BH3-only proteins" xref: Reactome:634221 "Caspase-8 is formed from procaspase-8" xref: Reactome:634343 "Activation, translocation and oligomerization of BAX" xref: Reactome:75108 "Activation, myristolyation of BID and translocation to mitochondria" is_a: GO:0043065 ! positive regulation of apoptosis relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0008634 name: negative regulation of survival gene product expression namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of survival gene product expression; survival gene products are those that antagonize the apoptotic program. Regulation can be at the transcriptional, translational, or posttranslational level." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "down regulation of survival gene product activity" BROAD [] synonym: "down-regulation of survival gene product activity" BROAD [] synonym: "downregulation of survival gene product activity" BROAD [] synonym: "inhibition of survival gene product activity" NARROW [] synonym: "negative regulation of survival gene product activity" BROAD [GOC:dph, GOC:tb] synonym: "negative regulation of survival gene products" BROAD [] is_a: GO:0010629 ! negative regulation of gene expression is_a: GO:0043065 ! positive regulation of apoptosis is_a: GO:0045884 ! regulation of survival gene product expression [Term] id: GO:0008635 name: activation of caspase activity by cytochrome c namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, mediated by cytochrome c." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase] synonym: "caspase activation via cytochrome c" EXACT [GOC:dph, GOC:tb] xref: Reactome:111459 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:563052 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:588666 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:609401 "Activation of caspases through apoptosome-mediated cleavage" xref: Reactome:634104 "Activation of caspases through apoptosome-mediated cleavage" is_a: GO:0006919 ! activation of caspase activity [Term] id: GO:0008636 name: activation of caspase activity by protein amino acid phosphorylation namespace: biological_process def: "Upregulation of the activity of a caspase, any of a group of cysteine proteases involved in apoptosis, by the addition of a phosphate group." [GOC:dph, GOC:jl, GOC:tb, Wikipedia:Caspase] synonym: "caspase activation via phosphorylation" EXACT [GOC:dph, GOC:tb] is_a: GO:0006468 ! protein amino acid phosphorylation is_a: GO:0006919 ! activation of caspase activity [Term] id: GO:0008637 name: apoptotic mitochondrial changes namespace: biological_process def: "The morphological and physiological alterations undergone by mitochondria during apoptosis." [GOC:mah] is_a: GO:0007005 ! mitochondrion organization relationship: part_of GO:0006915 ! apoptosis [Term] id: GO:0008638 name: protein tagging activity namespace: molecular_function def: "OBSOLETE. Covalent addition of a specific tagging molecule to a protein, targeting the tagged protein for some fate e.g. degradation." [GOC:jl] comment: This term was made obsolete because it represents a biological process and a molecular function. is_obsolete: true consider: GO:0005515 consider: GO:0006464 consider: GO:0031386 [Term] id: GO:0008641 name: small protein activating enzyme activity namespace: molecular_function alt_id: GO:0008642 def: "Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond." [GOC:jl, GOC:mah] subset: goslim_pir synonym: "ubiquitin-like activating enzyme activity" NARROW [] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008643 name: carbohydrate transport namespace: biological_process alt_id: GO:0006861 alt_id: GO:0008644 def: "The directed movement of carbohydrate into, out of, within or between cells by means of some external agent such as a transporter or pore. Carbohydrates are any of a group of organic compounds based of the general formula Cx(H2O)y." [GOC:ai] subset: goslim_pir subset: gosubset_prok synonym: "sugar transport" NARROW [] is_a: GO:0006810 ! transport [Term] id: GO:0008645 name: hexose transport namespace: biological_process def: "The directed movement of hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. Hexoses are any aldoses with a chain of six carbon atoms in the molecule." [GOC:ai] subset: gosubset_prok xref: Reactome:189200 "Hexose transport" xref: Reactome:562862 "Hexose transport" xref: Reactome:588482 "Hexose transport" xref: Reactome:609223 "Hexose transport" xref: Reactome:633916 "Hexose transport" xref: Reactome:645488 "Hexose transport" xref: Reactome:655850 "Hexose transport" xref: Reactome:661049 "Hexose transport" xref: Reactome:666825 "Hexose transport" xref: Reactome:672936 "Hexose transport" xref: Reactome:678649 "Hexose transport" xref: Reactome:683583 "Hexose transport" xref: Reactome:689819 "Hexose transport" xref: Reactome:701534 "Hexose transport" xref: Reactome:716118 "Hexose transport" xref: Reactome:720725 "Hexose transport" xref: Reactome:730979 "Hexose transport" xref: Reactome:735611 "Hexose transport" xref: Reactome:736635 "Hexose transport" is_a: GO:0015749 ! monosaccharide transport [Term] id: GO:0008646 name: high-affinity hexose transport namespace: biological_process def: "The directed, high-affinity movement of a hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] is_a: GO:0035428 ! hexose transmembrane transport [Term] id: GO:0008647 name: low-affinity hexose transport namespace: biological_process def: "The directed, low-affinity movement of a hexose into, out of, within or between cells by means of some external agent such as a transporter or pore. In low affinity transport the transporter is able to bind the solute only if it is only present at very low concentrations." [GOC:mah] is_a: GO:0035428 ! hexose transmembrane transport [Term] id: GO:0008648 name: tachykinin namespace: molecular_function def: "OBSOLETE. A family of hormones that stimulate secretion of saliva and cause smooth muscle contraction and vasodilation." [http://cancerweb.ncl.ac.uk/, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", ISBN:0721662544] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0005102 consider: GO:0045909 consider: GO:0045987 consider: GO:0046878 [Term] id: GO:0008649 name: rRNA methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008173 ! RNA methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity relationship: part_of GO:0031167 ! rRNA methylation [Term] id: GO:0008650 name: rRNA (uridine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing 2'-O-methyluridine." [GOC:mah] subset: gosubset_prok xref: EC:2.1.1.- is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0016436 ! rRNA (uridine) methyltransferase activity [Term] id: GO:0008651 name: actin polymerizing activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a biological process. is_obsolete: true replaced_by: GO:0030041 replaced_by: GO:0042802 [Term] id: GO:0008652 name: cellular amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amino acid biosynthetic process" EXACT [GOC:curators] synonym: "cellular amino acid anabolism" EXACT [] synonym: "cellular amino acid biosynthesis" EXACT [] synonym: "cellular amino acid formation" EXACT [] synonym: "cellular amino acid synthesis" EXACT [] xref: Reactome:562851 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:588471 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:609212 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:633905 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:645482 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:655843 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:661040 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:666817 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:672928 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:678641 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:683574 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:689810 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:701525 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:70614 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:716109 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:720718 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:728073 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:730983 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:733046 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:733885 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:735612 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:736569 "Amino acid synthesis and interconversion (transamination)" xref: Reactome:738529 "Amino acid synthesis and interconversion (transamination)" xref: Wikipedia:Amino_acid_synthesis is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0009309 ! amine biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0008653 name: lipopolysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipopolysaccharide metabolism" EXACT [] synonym: "LPS metabolic process" EXACT [] is_a: GO:0044255 ! cellular lipid metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0008654 name: phospholipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid anabolism" EXACT [] synonym: "phospholipid biosynthesis" EXACT [] synonym: "phospholipid formation" EXACT [] synonym: "phospholipid synthesis" EXACT [] xref: MetaCyc:LIPASYN-PWY xref: MetaCyc:PHOSLIPSYN-PWY xref: MetaCyc:PHOSLIPSYN2-PWY is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0008655 name: pyrimidine salvage namespace: biological_process def: "Any process that generates a pyrimidine, any nucleobase, nucleoside, nucleotide or nucleic acid that contains a pyrimidine base, from derivatives of them without de novo synthesis." [GOC:jl] subset: goslim_pir subset: gosubset_prok is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0008656 name: caspase activator activity namespace: molecular_function def: "Increases the rate of proteolysis catalyzed by a caspase." [GOC:mah] is_a: GO:0016505 ! apoptotic protease activator activity is_a: GO:0043028 ! caspase regulator activity [Term] id: GO:0008657 name: DNA topoisomerase (ATP-hydrolyzing) inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of ATP-hydrolyzing DNA topoisomerase. ATP-hydrolyzing DNA topoisomerase catalyzes the DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined; product release is coupled to ATP binding and hydrolysis; changes the linking number in multiples of 2." [GOC:mah] synonym: "DNA gyrase inhibitor activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity [Term] id: GO:0008658 name: penicillin binding namespace: molecular_function def: "Interacting selectively and non-covalently with penicillin, any antibiotic that contains the condensed beta-lactamthiazolidine ring system." [GOC:ai] subset: gosubset_prok is_a: GO:0008144 ! drug binding is_a: GO:0031406 ! carboxylic acid binding [Term] id: GO:0008659 name: (3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxytetradecanoyl-[acyl-carrier protein] = tetradecenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.-, GOC:ai] synonym: "(3R)-hydroxymyristoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "(3R)-hydroxymyristoyl-ACP dehydratase activity" EXACT [] xref: EC:4.2.1.- is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008660 name: 1-aminocyclopropane-1-carboxylate deaminase activity namespace: molecular_function alt_id: GO:0018806 def: "Catalysis of the reaction: 1-aminocyclopropane-1-carboxylate + H2O = 2-oxobutanoate + NH3." [EC:3.5.99.7] comment: Note that this function was formerly EC:4.1.99.4. subset: gosubset_prok synonym: "1-aminocyclopropane carboxylic acid deaminase activity" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate aminohydrolase (isomerizing)" EXACT [EC:3.5.99.7] synonym: "1-aminocyclopropane-1-carboxylate endolyase (deaminating) activity" EXACT [EC:3.5.99.7] synonym: "ACC deaminase activity" EXACT [EC:3.5.99.7] xref: EC:3.5.99.7 xref: MetaCyc:4.1.99.4-RXN xref: UM-BBD_enzymeID:e0274 is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008661 name: 1-deoxy-D-xylulose-5-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + D-glyceraldehyde 3-phosphate = 1-deoxy-D-xylulose 5-phosphate + CO2." [EC:2.2.1.7] subset: gosubset_prok synonym: "1-deoxy-D-xylulose-5-phosphate pyruvate-lyase (carboxylating) activity" EXACT [] synonym: "1-deoxyxylulose-5-phosphate synthase activity" EXACT [] synonym: "DOXP synthase activity" EXACT [] synonym: "DXP-synthase activity" EXACT [] synonym: "pyruvate:D-glyceraldehyde-3-phosphate acetaldehydetransferase (decarboxylating)" EXACT [EC:2.2.1.7] xref: EC:2.2.1.7 xref: MetaCyc:DXS-RXN is_a: GO:0016744 ! transferase activity, transferring aldehyde or ketonic groups [Term] id: GO:0008662 name: 1-phosphofructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose 1-phosphate = ADP + D-fructose 1,6-bisphosphate." [EC:2.7.1.56] subset: gosubset_prok synonym: "1-phosphofructokinase (phosphorylating)" EXACT [EC:2.7.1.56] synonym: "ATP:D-fructose-phosphate 6-phosphotransferase activity" EXACT [EC:2.7.1.56] synonym: "D-fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose 1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "fructose-1-phosphate kinase activity" EXACT [EC:2.7.1.56] synonym: "phosphofructokinase 1" RELATED [EC:2.7.1.56] xref: EC:2.7.1.56 xref: MetaCyc:1PFRUCTPHOSN-RXN is_a: GO:0008443 ! phosphofructokinase activity [Term] id: GO:0008663 name: 2',3'-cyclic-nucleotide 2'-phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 3'-phosphate." [EC:3.1.4.16] subset: gosubset_prok synonym: "2',3 '-cyclic AMP phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic AMP 2'-phosphohydrolase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleoside monophosphate phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2',3'-cyclic nucleotide phosphohydrolase" BROAD [EC:3.1.4.16] synonym: "2':3'-cyclic nucleotide phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "2':3'-cyclic phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide 2'-phosphodiesterase activity" EXACT [EC:3.1.4.16] synonym: "cyclic 2',3'-nucleotide phosphodiesterase" BROAD [EC:3.1.4.16] synonym: "cyclic phosphodiesterase:3'-nucleotidase activity" EXACT [EC:3.1.4.16] synonym: "nucleoside-2',3'-cyclic-phosphate 3'-nucleotidohydrolase activity" EXACT [EC:3.1.4.16] synonym: "ribonucleoside 2',3'-cyclic phosphate diesterase activity" EXACT [EC:3.1.4.16] xref: EC:3.1.4.16 xref: MetaCyc:CYCPHOSDIESTER-RXN is_a: GO:0004112 ! cyclic-nucleotide phosphodiesterase activity [Term] id: GO:0008664 name: 2'-5'-RNA ligase activity namespace: molecular_function def: "Catalysis of the formation of a phosphodiester bond between the 2'-hydroxyl group at the end of one DNA chain and the 5'-phosphate group at the end of another." [GOC:mah, PMID:8940112] subset: gosubset_prok synonym: "2'-5' RNA ligase activity" EXACT [] xref: EC:6.5.1.- is_a: GO:0008452 ! RNA ligase activity [Term] id: GO:0008665 name: 2'-phosphotransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from one compound to the 2' position of another." [GOC:jl, GOC:mah] subset: gosubset_prok xref: MetaCyc:2.7.1.160-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0008666 name: 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + 2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + H2O = CoA + N-succinyl-L-2-amino-6-oxoheptanedioate." [EC:2.3.1.117] subset: gosubset_prok synonym: "succinyl-CoA:(S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:2,3,4,5-tetrahydropyridine-2,6-dicarboxylate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "succinyl-CoA:tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate N-succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydrodipicolinate succinyltransferase activity" EXACT [EC:2.3.1.117] synonym: "tetrahydropicolinate succinylase activity" EXACT [EC:2.3.1.117] synonym: "THDP N-succinyltransferase activity" EXACT [PMID:19394346] xref: EC:2.3.1.117 xref: MetaCyc:TETHYDPICSUCC-RXN is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008667 name: 2,3-dihydro-2,3-dihydroxybenzoate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-dihydro-2,3-dihydroxybenzoate + NAD+ = 2,3-dihydroxybenzoate + NADH + H+." [EC:1.3.1.28] subset: gosubset_prok synonym: "2,3-DHB dehydrogenase activity" EXACT [EC:1.3.1.28] synonym: "2,3-dihydro-2,3-dihydroxybenzoate:NAD+ oxidoreductase activity" EXACT [EC:1.3.1.28] xref: EC:1.3.1.28 xref: MetaCyc:DHBDEHYD-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008668 name: (2,3-dihydroxybenzoyl)adenylate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-dihydroxybenzoate = diphosphate + (2,3-dihydroxybenzoyl)adenylate." [EC:2.7.7.58, MetaCyc:2.7.7.58-RXN] subset: gosubset_prok synonym: "2,3-dihydroxybenzoate-AMP ligase activity" EXACT [] synonym: "ATP:2,3-dihydroxybenzoate adenylyltransferase activity" EXACT [EC:2.7.7.58] xref: EC:2.7.7.58 xref: MetaCyc:DHBAMPLIG-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008669 name: 2,3-dihydroxy-phenylpropionate 1,2-dioxygenase activity namespace: molecular_function xref: EC:1.13.11.- is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008670 name: 2,4-dienoyl-CoA reductase (NADPH) activity namespace: molecular_function def: "Catalysis of the reaction: trans-2,3-didehydroacyl-CoA + NADP+ = trans,trans-2,3,4,5-tetradehydroacyl-CoA + NADPH + H+." [EC:1.3.1.34] subset: gosubset_prok synonym: "4-enoyl coenzyme A (reduced nicotinamide adenine dinucleotide phosphate) reductase activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH) activity" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase (NADPH2)" EXACT [EC:1.3.1.34] synonym: "4-enoyl-CoA reductase activity" EXACT [EC:1.3.1.34] synonym: "trans-2,3-didehydroacyl-CoA:NADP+ 4-oxidoreductase activity" EXACT [EC:1.3.1.34] xref: EC:1.3.1.34 xref: MetaCyc:DIENOYLCOAREDUCT-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008671 name: 2-dehydro-3-deoxygalactonokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-galactonate = ADP + 2-dehydro-3-deoxy-D-galactonate 6-phosphate." [EC:2.7.1.58] subset: gosubset_prok synonym: "2-keto-3-deoxy-galactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonate kinase (phosphorylating)" EXACT [EC:2.7.1.58] synonym: "2-keto-3-deoxygalactonokinase activity" EXACT [EC:2.7.1.58] synonym: "2-oxo-3-deoxygalactonate kinase activity" EXACT [EC:2.7.1.58] synonym: "ATP:2-dehydro-3-deoxy-D-galactonate 6-phosphotransferase activity" EXACT [EC:2.7.1.58] xref: EC:2.7.1.58 xref: MetaCyc:DEHYDDEOXGALACTKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008672 name: 2-dehydro-3-deoxyglucarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-glucarate = pyruvate + tartronate semialdehyde." [EC:4.1.2.20] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase (pyruvate-forming)" EXACT [EC:4.1.2.20] synonym: "2-dehydro-3-deoxy-D-glucarate tartronate-semialdehyde-lyase activity" EXACT [EC:4.1.2.20] synonym: "2-keto-3-deoxyglucarate aldolase activity" EXACT [EC:4.1.2.20] synonym: "alpha-keto-beta-deoxy-D-glucarate aldolase activity" EXACT [EC:4.1.2.20] xref: EC:4.1.2.20 xref: MetaCyc:KDGALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008673 name: 2-dehydro-3-deoxygluconokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2-dehydro-3-deoxy-D-gluconate = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.45] subset: gosubset_prok synonym: "2-keto-3-deoxy-D-gluconic acid kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase (phosphorylating)" EXACT [EC:2.7.1.45] synonym: "2-keto-3-deoxygluconokinase activity" EXACT [EC:2.7.1.45] synonym: "3-deoxy-2-oxo-D-gluconate kinase activity" EXACT [EC:2.7.1.45] synonym: "ATP:2-dehydro-3-deoxy-D-gluconate 6-phosphotransferase activity" EXACT [EC:2.7.1.45] synonym: "KDG kinase activity" EXACT [EC:2.7.1.45] synonym: "ketodeoxygluconokinase activity" EXACT [EC:2.7.1.45] xref: EC:2.7.1.45 xref: MetaCyc:DEOXYGLUCONOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008674 name: 2-dehydro-3-deoxy-6-phosphogalactonate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-galactonate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.21] subset: gosubset_prok synonym: "(KDPGal)aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxy-D-galactonate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.21] synonym: "2-dehydro-3-deoxyphosphogalactonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-6-phosphogalactonic acid aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-keto-3-deoxy-6-phosphogalactonic aldolase activity" EXACT [EC:4.1.2.21] synonym: "2-oxo-3-deoxygalactonate 6-phosphate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-dehydro-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "6-phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonate aldolase activity" EXACT [EC:4.1.2.21] synonym: "phospho-2-keto-3-deoxygalactonic aldolase activity" EXACT [EC:4.1.2.21] xref: EC:4.1.2.21 xref: MetaCyc:DEHYDDEOXPHOSGALACT-ALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008675 name: 2-dehydro-3-deoxy-phosphogluconate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate 6-phosphate = pyruvate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.14] subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase (pyruvate-forming)" EXACT [EC:4.1.2.14] synonym: "2-dehydro-3-deoxy-D-gluconate-6-phosphate D-glyceraldehyde-3-phosphate-lyase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxy-6-phosphogluconic aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-P-aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-keto-3-deoxygluconate-6-phosphate aldolase activity" EXACT [EC:4.1.2.14] synonym: "2-oxo-3-deoxy-6-phosphogluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "6-phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "KDPG-aldolase activity" EXACT [EC:4.1.2.14] synonym: "ODPG aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-dehydro-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconate aldolase activity" EXACT [EC:4.1.2.14] synonym: "phospho-2-keto-3-deoxygluconic aldolase activity" EXACT [EC:4.1.2.14] xref: EC:4.1.2.14 xref: MetaCyc:KDPGALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008676 name: 3-deoxy-8-phosphooctulonate synthase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + D-arabinose 5-phosphate + H2O = 2-dehydro-3-deoxy-D-octonate 8-phosphate + phosphate." [EC:2.5.1.55] comment: Note that this function was formerly EC:4.1.2.16. subset: gosubset_prok synonym: "2-dehydro-3-deoxy-D-octonate-8-phosphate D-arabinose-5-phosphate-lyase (pyruvate-phosphorylating) activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxy-phosphooctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "2-dehydro-3-deoxyphosphooctonate aldolase activity" EXACT [] synonym: "2-keto-3-deoxy-8-phosphooctonic synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonate-8-phosphate synthase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-manno-octulosonic acid 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxy-D-mannooctulosonate-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "3-deoxyoctulosonic 8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-P synthase activity" EXACT [EC:2.5.1.55] synonym: "KDO-8-phosphate synthetase activity" EXACT [EC:2.5.1.55] synonym: "KDOP synthase activity" EXACT [EC:2.5.1.55] synonym: "phospho-2-keto-3-deoxyoctonate aldolase activity" EXACT [EC:2.5.1.55] synonym: "phosphoenolpyruvate:D-arabinose-5-phosphate C-(1-carboxyvinyl)transferase (phosphate-hydrolysing, 2-carboxy-2-oxoethyl-forming)" EXACT [EC:2.5.1.55] xref: EC:2.5.1.55 xref: MetaCyc:KDO-8PSYNTH-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008677 name: 2-dehydropantoate 2-reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + NADPH + H+." [EC:1.1.1.169] subset: gosubset_prok synonym: "(R)-pantoate:NADP+ 2-oxidoreductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "2-ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "2-oxopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoate reductase activity" EXACT [EC:1.1.1.169] synonym: "ketopantoic acid reductase activity" EXACT [EC:1.1.1.169] synonym: "KPA reductase activity" EXACT [EC:1.1.1.169] xref: EC:1.1.1.169 xref: MetaCyc:2-DEHYDROPANTOATE-REDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008678 name: 2-deoxy-D-gluconate 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 2-deoxy-D-gluconate + NAD+ = 3-dehydro-2-deoxy-D-gluconate + NADH + H+." [EC:1.1.1.125] subset: gosubset_prok synonym: "2-deoxy-D-gluconate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.125] synonym: "2-deoxygluconate dehydrogenase activity" EXACT [EC:1.1.1.125] synonym: "2-keto-3-deoxygluconate oxidoreductase activity" EXACT [EC:1.1.1.125] xref: EC:1.1.1.125 xref: MetaCyc:KDUD-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008679 name: 2-hydroxy-3-oxopropionate reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-glycerate + NADP+ = 2-hydroxy-3-oxopropanoate + NADPH + H+." [EC:1.1.1.60] subset: gosubset_prok synonym: "(R)-glycerate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.60] synonym: "tartronate semialdehyde reductase activity" EXACT [EC:1.1.1.60] xref: EC:1.1.1.60 xref: MetaCyc:TSA-REDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008681 name: 2-octaprenyl-6-methoxyphenol hydroxylase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0016705 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [Term] id: GO:0008682 name: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-octoprenyl-3-methyl-6-methoxy-1,4-benzoquinone + O2 = 2-octoprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone." [MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN] xref: MetaCyc:OCTAPRENYL-METHYL-METHOXY-BENZOQ-OH-RXN is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008683 name: 2-oxoglutarate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: 2-oxoglutarate = succinate semialdehyde + CO2." [EC:4.1.1.71] subset: gosubset_prok synonym: "2-oxoglutarate carboxy-lyase (succinate-semialdehyde-forming)" EXACT [EC:4.1.1.71] synonym: "2-oxoglutarate carboxy-lyase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "alpha-ketoglutaric decarboxylase activity" EXACT [EC:4.1.1.71] synonym: "pre-2-oxoglutarate decarboxylase activity" EXACT [EC:4.1.1.71] xref: EC:4.1.1.71 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008684 name: 2-oxopent-4-enoate hydratase activity namespace: molecular_function alt_id: GO:0018821 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O." [EC:4.2.1.80] subset: gosubset_prok synonym: "2-keto-4-pentenoate (vinylpyruvate)hydratase activity" EXACT [EC:4.2.1.80] synonym: "2-keto-4-pentenoate hydratase activity" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase (2-oxopent-4-enoate-forming)" EXACT [EC:4.2.1.80] synonym: "4-hydroxy-2-oxopentanoate hydro-lyase activity" EXACT [EC:4.2.1.80] synonym: "OEH activity" EXACT [EC:4.2.1.80] xref: EC:4.2.1.80 xref: MetaCyc:2-OXOPENT-4-ENOATE-HYDRATASE-RXN xref: UM-BBD_enzymeID:e0078 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008685 name: 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol = 2-C-methyl-D-erythritol 2,4-cyclodiphosphate + CMP." [EC:4.6.1.12, GOC:mlg] subset: gosubset_prok synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing)" EXACT [EC:4.6.1.12] synonym: "2-phospho-4-(cytidine 5'-diphospho)-2-C-methyl-D-erythritol CMP-lyase (cyclizing; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate-forming)" EXACT [EC:4.6.1.12] synonym: "MECDP-synthase activity" EXACT [EC:4.6.1.12] synonym: "MECP synthase activity" EXACT [] xref: EC:4.6.1.12 xref: MetaCyc:RXN0-302 is_a: GO:0016849 ! phosphorus-oxygen lyase activity [Term] id: GO:0008686 name: 3,4-dihydroxy-2-butanone-4-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ribulose-5-phosphate = 3,4-dihydroxy-2-butanone-4-phosphate + formate." [MetaCyc:DIOHBUTANONEPSYN-RXN] subset: gosubset_prok xref: EC:4.1.99.12 xref: MetaCyc:DIOHBUTANONEPSYN-RXN is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0008687 name: 3,4-dihydroxyphenylacetate 2,3-dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3,4-dihydroxyphenylacetate + O2 = 2-hydroxy-5-carboxymethylmuconate semialdehyde." [EC:1.13.11.15] subset: gosubset_prok synonym: "3,4-dihydroxyphenylacetate:oxygen 2,3-oxidoreductase (decyclizing)" EXACT [EC:1.13.11.15] synonym: "3,4-dihydroxyphenylacetic acid 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "homoprotocatechuate 2,3-dioxygenase activity" EXACT [EC:1.13.11.15] synonym: "HPC dioxygenase activity" EXACT [EC:1.13.11.15] xref: EC:1.13.11.15 xref: MetaCyc:1.13.11.15-RXN xref: UM-BBD_enzymeID:e0125 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0008688 name: 3-(3-hydroxy-phenyl)propionate hydroxylase activity namespace: molecular_function xref: EC:1.14.13.- xref: MetaCyc:MHPHYDROXY-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008689 name: 3-demethylubiquinone-9 3-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-demethylubiquinone-9 = S-adenosyl-L-homocysteine + ubiquinone-9." [EC:2.1.1.64] subset: gosubset_prok synonym: "5-demethylubiquinone-9 methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "OMHMB-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-nonaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone 3-O-methyltransferase activity" EXACT [EC:2.1.1.64] synonym: "S-adenosyl-L-methionine:2-octaprenyl-3-methyl-5-hydroxy-6-methoxy-1,4-benzoquinone-O-methyltransferase activity" EXACT [EC:2.1.1.64] xref: EC:2.1.1.64 xref: MetaCyc:DHHB-METHYLTRANSFER-RXN is_a: GO:0008171 ! O-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008690 name: 3-deoxy-manno-octulosonate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate." [EC:2.7.7.38] subset: gosubset_prok synonym: "2-keto-3-deoxyoctonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CMP-2-keto-3-deoxyoctulosonic acid synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate diphosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] synonym: "CMP-3-deoxy-D-manno-octulosonate synthetase activity" EXACT [EC:2.7.7.38] synonym: "CMP-KDO synthetase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "CTP:3-deoxy-manno-octulosonate cytidylyltransferase activity" EXACT [] synonym: "CTP:CMP-3-deoxy-D-manno-octulosonate cytidylyltransferase activity" EXACT [EC:2.7.7.38] synonym: "cytidine monophospho-3-deoxy-D-manno-octulosonate pyrophosphorylase activity" EXACT [EC:2.7.7.38] xref: EC:2.7.7.38 xref: MetaCyc:CPM-KDOSYNTH-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008691 name: 3-hydroxybutyryl-CoA dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA + NADP+ = 3-acetoacetyl-CoA + NADPH + H+." [EC:1.1.1.157] subset: gosubset_prok synonym: "(S)-3-hydroxybutanoyl-CoA:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl coenzyme A dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "beta-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "BHBD activity" EXACT [EC:1.1.1.157] synonym: "dehydrogenase, L-3-hydroxybutyryl coenzyme A (nicotinamide adenine dinucleotide phosphate)" EXACT [EC:1.1.1.157] synonym: "L(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] synonym: "L-(+)-3-hydroxybutyryl-CoA dehydrogenase activity" EXACT [EC:1.1.1.157] xref: EC:1.1.1.157 xref: MetaCyc:3-HYDROXYBUTYRYL-COA-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008692 name: 3-hydroxybutyryl-CoA epimerase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-3-hydroxybutanoyl-CoA = (R)-3-hydroxybutanoyl-CoA." [EC:5.1.2.3] subset: gosubset_prok synonym: "3-hydroxyacyl-CoA epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutanoyl-CoA 3-epimerase activity" EXACT [EC:5.1.2.3] synonym: "3-hydroxybutyryl coenzyme A epimerase activity" EXACT [EC:5.1.2.3] xref: EC:5.1.2.3 xref: MetaCyc:OHBUTYRYL-COA-EPIM-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008693 name: 3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (3R)-3-hydroxydecanoyl-[acyl-carrier protein] = 2,3-decenoyl-[acyl-carrier protein] or 3,4-decenoyl-[acyl-carrier protein] + H2O." [EC:4.2.1.60] subset: gosubset_prok synonym: "(3R)-3-hydroxydecanoyl-acyl-carrier-protein hydro-lyase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-[acyl-carrier protein] dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-ACP dehydratase activity" EXACT [] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydrase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-ACP dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxyacyl-acyl carrier protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoate dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thioester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "beta-hydroxydecanoyl thiol ester dehydrase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-[acyl-carrier-protein] dehydratase activity" EXACT [EC:4.2.1.60] synonym: "D-3-hydroxydecanoyl-acyl-carrier-protein dehydratase activity" EXACT [EC:4.2.1.60] synonym: "FabA" RELATED [EC:4.2.1.60] synonym: "HDDase activity" EXACT [EC:4.2.1.60] xref: EC:4.2.1.60 xref: MetaCyc:3-HYDROXYDECANOYL-ACP-DEHYDR-RXN is_a: GO:0019171 ! 3-hydroxyacyl-[acyl-carrier-protein] dehydratase activity [Term] id: GO:0008694 name: 3-octaprenyl-4-hydroxybenzoate carboxy-lyase activity namespace: molecular_function alt_id: GO:0019167 def: "Catalysis of the reaction: 3-octaprenyl-4-hydroxy benzoate = 2-octaprenylphenol + CO2." [MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN] subset: gosubset_prok synonym: "3-octaprenyl-4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl 4-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "3-polyprenyl-4-hydroxybenzoate carboxy-lyase activity" EXACT [] synonym: "polyprenyl p-hydroxybenzoate decarboxylase activity" EXACT [] synonym: "PPHB decarboxylase activity" EXACT [] synonym: "UbiD" RELATED [] synonym: "UbiX" RELATED [] xref: EC:4.1.1.- xref: MetaCyc:3-OCTAPRENYL-4-OHBENZOATE-DECARBOX-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008695 name: 3-phenylpropionate dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-phenylpropionate + NADH + H+ + O2 = NAD+ + cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol." [UM-BBD_enzymeID:e0307] synonym: "3-phenylpropanoate dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "3-phenylpropanoate,NADH:oxygen oxidoreductase (2,3-hydroxylating) activity" EXACT [EC:1.14.12.19] synonym: "Hca dioxygenase activity" EXACT [EC:1.14.12.19] synonym: "HcaA1A2CD" RELATED [EC:1.14.12.19] xref: EC:1.14.12.19 xref: MetaCyc:HCAMULTI-RXN xref: UM-BBD_enzymeID:e0307 is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008696 name: 4-amino-4-deoxychorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: 4-amino-4-deoxychorismate = p-aminobenzoate + pyruvate." [MetaCyc:ADCLY-RXN] comment: Note that the name 'para-amino benzoic acid synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional 4-amino-4-deoxychorismate lyase activity was discovered. It is the lyase activity that actually produces para-aminobenzoic acid from 4-amino-4-deoxychorismate. subset: gosubset_prok synonym: "4-amino-4-deoxychorismate pyruvate-lyase (4-aminobenzoate-forming)" EXACT [EC:4.1.3.38] synonym: "4-amino-4-deoxychorismate pyruvate-lyase activity" EXACT [EC:4.1.3.38] synonym: "ADC lyase activity" EXACT [EC:4.1.3.38] synonym: "aminodeoxychorismate lyase activity" EXACT [] synonym: "enzyme X activity" RELATED [EC:4.1.3.38] synonym: "p-aminobenzoate synthetase" RELATED [] synonym: "para-aminobenzoic acid (PABA) synthase" RELATED [] synonym: "para-aminobenzoic acid synthase" RELATED [] xref: EC:4.1.3.38 xref: MetaCyc:ADCLY-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008697 name: 4-deoxy-L-threo-5-hexosulose-uronate ketol-isomerase activity namespace: molecular_function def: "Catalysis of the reaction: 4-deoxy-L-threo-5-hexosulose uronate = 3-deoxy-D-glycero-2,5-hexodiulosonate." [EC:5.3.1.17] subset: gosubset_prok synonym: "4-deoxy-L-threo-5-hexosulose-uronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.17] synonym: "4-deoxy-L-threo-5-hexulose uronate isomerase activity" EXACT [EC:5.3.1.17] synonym: "5-keto-4-deoxyuronate isomerase activity" EXACT [EC:5.3.1.17] xref: EC:5.3.1.17 xref: MetaCyc:5.3.1.17-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008700 name: 4-hydroxy-2-oxoglutarate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: 4-hydroxy-2-oxoglutarate = pyruvate + glyoxylate." [EC:4.1.3.16] subset: gosubset_prok synonym: "2-keto-4-hydroxybutyrate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-keto-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "2-oxo-4-hydroxyglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-ketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase (pyruvate-forming)" EXACT [EC:4.1.3.16] synonym: "4-hydroxy-2-oxoglutarate glyoxylate-lyase activity" EXACT [EC:4.1.3.16] synonym: "DL-4-hydroxy-2-ketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutarate aldolase activity" EXACT [EC:4.1.3.16] synonym: "hydroxyketoglutaric aldolase activity" EXACT [EC:4.1.3.16] synonym: "KHG-aldolase activity" EXACT [EC:4.1.3.16] xref: EC:4.1.3.16 xref: MetaCyc:4OH2OXOGLUTARALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008701 name: 4-hydroxy-2-oxovalerate aldolase activity namespace: molecular_function alt_id: GO:0018804 def: "Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = pyruvate + acetaldehyde." [EC:4.1.3.39] synonym: "4-hydroxy-2-ketovalerate aldolase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase (acetaldehyde-forming) activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxopentanoate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "4-hydroxy-2-oxovalerate pyruvate-lyase activity" EXACT [EC:4.1.3.39] synonym: "DmpG" RELATED [EC:4.1.3.39] synonym: "HOA" RELATED [EC:4.1.3.39] xref: EC:4.1.3.39 xref: MetaCyc:MHPELY-RXN xref: UM-BBD_enzymeID:e0077 is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008703 name: 5-amino-6-(5-phosphoribosylamino)uracil reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-amino-6-(5-phosphoribitylamino)uracil + NADP+ = 5-amino-6-(5-phosphoribosylamino)uracil + NADPH + H+." [EC:1.1.1.193] subset: gosubset_prok synonym: "5-amino-6-(5'-phosphoribosylamino)uracil reductase activity" EXACT [] synonym: "5-amino-6-(5-phosphoribitylamino)uracil:NADP+ 1'-oxidoreductase activity" EXACT [EC:1.1.1.193] synonym: "aminodioxyphosphoribosylaminopyrimidine reductase activity" EXACT [EC:1.1.1.193] xref: EC:1.1.1.193 xref: MetaCyc:RIBOFLAVINSYNREDUC-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008704 name: 5-carboxymethyl-2-hydroxymuconate delta-isomerase activity namespace: molecular_function alt_id: GO:0018843 def: "Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate." [EC:5.3.3.10] subset: gosubset_prok synonym: "2-hydroxyhepta-2,4-diene-1,7-dioate isomerase" RELATED [] synonym: "5-carboxymethyl-2-hydroxymuconate D-isomerase activity" EXACT [] synonym: "5-carboxymethyl-2-hydroxymuconate delta2,Delta4-2-oxo,Delta3-isomerase activity" EXACT [EC:5.3.3.10] synonym: "5-carboxymethyl-2-hydroxymuconic acid isomerase activity" EXACT [EC:5.3.3.10] synonym: "CHM isomerase activity" EXACT [EC:5.3.3.10] synonym: "HHDD isomerase activity" EXACT [] synonym: "hpaG-1" RELATED [] synonym: "hpaG1" RELATED [] xref: EC:5.3.3.10 xref: MetaCyc:5.3.3.10-RXN xref: UM-BBD_enzymeID:e0135 is_a: GO:0016863 ! intramolecular oxidoreductase activity, transposing C=C bonds [Term] id: GO:0008705 name: methionine synthase activity namespace: molecular_function def: "Catalysis of the reaction: 5-methyltetrahydrofolate + L-homocysteine = tetrahydrofolate + L-methionine." [EC:2.1.1.13] subset: gosubset_prok synonym: "5-methyltetrahydrofolate--homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate--homocysteine transmethylase activity" EXACT [EC:2.1.1.13] synonym: "5-methyltetrahydrofolate-homocysteine S-methyltransferase activity" EXACT [] synonym: "5-methyltetrahydrofolate:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N(5)-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "B12 N5-methyltetrahydrofolate homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "cobalamin-dependent methionine synthase activity" EXACT [EC:2.1.1.13] synonym: "MetH" RELATED [EC:2.1.1.13] synonym: "methionine synthase (cobalamin-dependent) activity" EXACT [EC:2.1.1.13] synonym: "methyltetrahydrofolate--homocysteine vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolate--homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N(5)-methyltetrahydrofolic--homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "N-methyltetrahydrofolate:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolate-homocysteine cobalamin methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "N5-methyltetrahydrofolic-homocysteine vitamin B12 transmethylase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydrofolate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamate methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "tetrahydropteroylglutamic methyltransferase activity" EXACT [EC:2.1.1.13] synonym: "vitamin B12 methyltransferase activity" EXACT [EC:2.1.1.13] xref: EC:2.1.1.13 xref: MetaCyc:HOMOCYSMETB12-RXN xref: Reactome:25894 "methionine synthase activity" is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0042084 ! 5-methyltetrahydrofolate-dependent methyltransferase activity relationship: part_of GO:0009086 ! methionine biosynthetic process [Term] id: GO:0008706 name: 6-phospho-beta-glucosidase activity namespace: molecular_function def: "Catalysis of the reaction: 6-phospho-beta-D-glucoside-(1,4)-D-glucose + H2O = D-glucose 6-phosphate + glucose." [EC:3.2.1.86] subset: gosubset_prok synonym: "6-phospho-beta-D-glucosyl-(1,4)-D-glucose glucohydrolase activity" EXACT [EC:3.2.1.86] synonym: "phospho-beta-glucosidase A" RELATED [EC:3.2.1.86] synonym: "phospho-beta-glucosidase activity" EXACT [EC:3.2.1.86] synonym: "phosphocellobiase activity" EXACT [EC:3.2.1.86] xref: EC:3.2.1.86 xref: MetaCyc:6-PHOSPHO-BETA-GLUCOSIDASE-RXN is_a: GO:0008422 ! beta-glucosidase activity [Term] id: GO:0008707 name: 4-phytase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol hexakisphosphate + H2O = 1-myo-inositol 1,2,3,4,5-pentakisphosphate + phosphate." [EC:3.1.3.26] subset: gosubset_prok synonym: "6-phytase (name based on 1L-numbering system and not 1D-numbering)" BROAD [EC:3.1.3.26] synonym: "6-phytase activity" EXACT [] synonym: "myo-inositol-hexakisphosphate 6-phosphohydrolase activity" EXACT [EC:3.1.3.26] synonym: "phytase activity" BROAD [EC:3.1.3.26] synonym: "phytate 6-phosphatase activity" EXACT [EC:3.1.3.26] xref: EC:3.1.3.26 xref: MetaCyc:6-PHYT-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008709 name: 7-alpha-hydroxysteroid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholanate + NAD+ = 3-alpha,12-alpha-dihydroxy-7-oxo-5-beta-cholanate + NADH + H+." [EC:1.1.1.159] subset: gosubset_prok synonym: "7alpha-HSDH" RELATED [EC:1.1.1.159] synonym: "7alpha-hydroxy steroid dehydrogenase activity" EXACT [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid dehydrogenase activity" EXACT [EC:1.1.1.159] synonym: "7alpha-hydroxysteroid:NAD+ 7-oxidoreductase activity" EXACT [EC:1.1.1.159] xref: EC:1.1.1.159 xref: MetaCyc:7-ALPHA-HYDROXYSTEROID-DEH-RXN is_a: GO:0033764 ! steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008710 name: 8-amino-7-oxononanoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: 6-carboxyhexanoyl-CoA + L-alanine = 8-amino-7-oxononanoate + CoA + CO2." [EC:2.3.1.47] subset: gosubset_prok synonym: "6-carboxyhexanoyl-CoA:L-alanine C-carboxyhexanoyltransferase (decarboxylating)" EXACT [EC:2.3.1.47] synonym: "7-KAP synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-amino-pelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic acid synthetase activity" EXACT [EC:2.3.1.47] synonym: "7-keto-8-aminopelargonic synthetase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-ketopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "8-amino-7-oxopelargonate synthase activity" EXACT [EC:2.3.1.47] synonym: "AONS activity" EXACT [EC:2.3.1.47] xref: EC:2.3.1.47 xref: MetaCyc:7KAPSYN-RXN is_a: GO:0016747 ! transferase activity, transferring acyl groups other than amino-acyl groups [Term] id: GO:0008711 name: ADP-L-glycero-D-manno-heptose synthase activity namespace: molecular_function def: "OBSOLETE." [GOC:curators] comment: This term was made obsolete because it represents a bifunctional gene product (e.g. E. coli RfaE). is_obsolete: true consider: GO:0033785 consider: GO:0033786 [Term] id: GO:0008712 name: ADP-glyceromanno-heptose 6-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose." [EC:5.1.3.20] subset: gosubset_prok synonym: "ADP-L-glycero-D-manno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] synonym: "ADPglyceromanno-heptose 6-epimerase activity" EXACT [EC:5.1.3.20] xref: EC:5.1.3.20 xref: MetaCyc:5.1.3.20-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008713 name: ADP-heptose-lipopolysaccharide heptosyltransferase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0008920 ! lipopolysaccharide heptosyltransferase activity [Term] id: GO:0008714 name: AMP nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + H2O = adenine + D-ribose 5-phosphate." [EC:3.2.2.4] subset: gosubset_prok synonym: "adenosine monophosphate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "adenylate nucleosidase activity" EXACT [EC:3.2.2.4] synonym: "AMP phosphoribohydrolase activity" EXACT [EC:3.2.2.4] xref: EC:3.2.2.4 xref: MetaCyc:AMP-NUCLEOSID-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008715 name: CDP-diacylglycerol diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: CDP-diacylglycerol + H2O = CMP + phosphatidate." [EC:3.6.1.26] subset: gosubset_prok synonym: "CDP diacylglycerol hydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol phosphatidylhydrolase activity" EXACT [EC:3.6.1.26] synonym: "CDP-diacylglycerol pyrophosphatase activity" EXACT [] synonym: "cytidine diphosphodiacylglycerol pyrophosphatase activity" EXACT [EC:3.6.1.26] xref: EC:3.6.1.26 xref: MetaCyc:CDPDIGLYPYPHOSPHA-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008716 name: D-alanine-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2 D-alanine = ADP + phosphate + D-alanyl-D-alanine." [EC:6.3.2.4] subset: gosubset_prok synonym: "alanine:alanine ligase (ADP-forming) activity" EXACT [EC:6.3.2.4] synonym: "alanylalanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-Ala-D-Ala synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanine:D-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.4] synonym: "D-alanyl-D-alanine synthetase activity" EXACT [EC:6.3.2.4] synonym: "D-alanylalanine synthetase activity" EXACT [EC:6.3.2.4] xref: EC:6.3.2.4 xref: MetaCyc:DALADALALIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008717 name: D-alanyl-D-alanine endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "penicillin-binding protein 7" NARROW [] synonym: "penicillin-binding protein 8" NARROW [] xref: EC:3.4.99.- is_obsolete: true replaced_by: GO:0004175 [Term] id: GO:0008718 name: D-amino-acid dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: a D-amino acid + H2O + acceptor = a 2-oxo acid + NH3 + reduced acceptor." [EC:1.4.99.1] subset: gosubset_prok synonym: "D-amino-acid:(acceptor) oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] synonym: "D-amino-acid:acceptor oxidoreductase (deaminating)" EXACT [EC:1.4.99.1] xref: EC:1.4.99.1 xref: MetaCyc:DAADEHYDROG-RXN is_a: GO:0016638 ! oxidoreductase activity, acting on the CH-NH2 group of donors [Term] id: GO:0008719 name: dihydroneopterin triphosphate 2'-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dihydroneopterin triphosphate = dihydromonapterin-triphosphate." [MetaCyc:H2NTPEPIM-RXN] subset: gosubset_prok synonym: "D-erythro-7,8-dihydroneopterin triphosphate 2'-epimerase activity" EXACT [] xref: EC:5.-.-.- xref: MetaCyc:H2NTPEPIM-RXN is_a: GO:0016853 ! isomerase activity [Term] id: GO:0008720 name: D-lactate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-lactate + NAD+ = pyruvate + NADH + H+." [EC:1.1.1.28] subset: gosubset_prok synonym: "D-lactic acid dehydrogenase activity" EXACT [EC:1.1.1.28] synonym: "D-lactic dehydrogenase activity" EXACT [EC:1.1.1.28] xref: EC:1.1.1.28 xref: MetaCyc:DLACTDEHYDROGNAD-RXN is_a: GO:0004457 ! lactate dehydrogenase activity is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008721 name: D-serine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: D-serine = pyruvate + NH3." [EC:4.3.1.18] comment: Note that this function was formerly EC:4.3.1.14. subset: gosubset_prok synonym: "D-hydroxy amino acid dehydratase activity" BROAD [EC:4.3.1.18] synonym: "D-hydroxyaminoacid dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine ammonia-lyase (pyruvate-forming)" EXACT [EC:4.3.1.18] synonym: "D-serine deaminase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydrase activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine dehydratase activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydro-lyase (deaminating) activity" EXACT [EC:4.3.1.18] synonym: "D-serine hydrolase activity" EXACT [EC:4.3.1.18] xref: EC:4.3.1.18 xref: MetaCyc:DSERDEAM-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008724 name: DNA topoisomerase IV activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-independent breakage of DNA, followed by passage and rejoining. It also catalyzes the relaxation of supercoiled DNA, and the decatenation and unknotting of DNA in vivo." [EC:5.99.1.-, PMID:11274059] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0003918 [Term] id: GO:0008725 name: DNA-3-methyladenine glycosylase I activity namespace: molecular_function def: "Catalysis of the hydrolysis of alkylated DNA; only recognizes and removes the alkylated base 3-methyladenine by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic (AP) site." [EC:3.2.2.20, GOC:elh, PMID:10872450, PMID:9224623] subset: gosubset_prok synonym: "3-methyladenine DNA glycosylase I" RELATED [EC:3.2.2.20] synonym: "alkylated-DNA glycohydrolase (releasing methyladenine and methylguanine)" BROAD [EC:3.2.2.20] synonym: "deoxyribonucleate 3-methyladenine glycosidase I" RELATED [EC:3.2.2.20] synonym: "DNA glycosidase I activity" RELATED [EC:3.2.2.20] synonym: "DNA-3-methyladenine glycosidase I activity" EXACT [EC:3.2.2.20] xref: EC:3.2.2.20 xref: MetaCyc:3.2.2.20-RXN is_a: GO:0003905 ! alkylbase DNA N-glycosylase activity [Term] id: GO:0008726 name: alkanesulfonate monooxygenase activity namespace: molecular_function def: "Catalysis of the reaction: an alkanesulfonate + O2 + FMNH2 = an aldehyde + SO3(2-) (sulfite) + H2O + FMN." [MetaCyc:RXN0-280] subset: gosubset_prok synonym: "alkanesulfonate, reduced-FMN:oxygen oxidoreductase activity" EXACT [EC:1.14.14.5] synonym: "alkanesulphonate monooxygenase activity" EXACT [] synonym: "FMNH(2)-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "FMNH(2)-dependent alkanesulfonate monooxygenase activity" EXACT [] synonym: "FMNH2-dependent aliphatic sulfonate monooxygenase activity" EXACT [EC:1.14.14.5] synonym: "SsuD" RELATED [EC:1.14.14.5] synonym: "sulfate starvation-induced protein 6 activity" RELATED [EC:1.14.14.5] xref: EC:1.14.14.5 xref: MetaCyc:RXN0-280 is_a: GO:0016712 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen [Term] id: GO:0008727 name: GDP-mannose mannosyl hydrolase activity namespace: molecular_function xref: MetaCyc:GDPMANMANHYDRO-RXN is_a: GO:0015923 ! mannosidase activity [Term] id: GO:0008728 name: GTP diphosphokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate." [EC:2.7.6.5] subset: gosubset_prok synonym: "(p)ppGpp synthetase I" RELATED [EC:2.7.6.5] synonym: "(p)ppGpp synthetase II" RELATED [EC:2.7.6.5] synonym: "ATP-GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "ATP:GTP 3'-diphosphotransferase activity" EXACT [EC:2.7.6.5] synonym: "GPSI" RELATED [EC:2.7.6.5] synonym: "GPSII" RELATED [EC:2.7.6.5] synonym: "GTP pyrophosphokinase activity" EXACT [] synonym: "guanosine 3',5'-polyphosphate synthase activity" EXACT [EC:2.7.6.5] synonym: "guanosine 5',3'-polyphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "guanosine pentaphosphate synthetase activity" EXACT [EC:2.7.6.5] synonym: "ppGpp synthetase I activity" EXACT [EC:2.7.6.5] synonym: "stringent factor activity" RELATED [EC:2.7.6.5] xref: EC:2.7.6.5 xref: MetaCyc:GTPPYPHOSKIN-RXN is_a: GO:0016778 ! diphosphotransferase activity [Term] id: GO:0008730 name: L(+)-tartrate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: (R,R)-tartrate = oxaloacetate + H2O." [EC:4.2.1.32] subset: gosubset_prok synonym: "(R,R)-tartrate hydro-lyase (oxaloacetate-forming)" EXACT [EC:4.2.1.32] synonym: "(R,R)-tartrate hydro-lyase activity" EXACT [EC:4.2.1.32] synonym: "L-(+)-tartaric acid dehydratase activity" EXACT [EC:4.2.1.32] synonym: "L-tartrate dehydratase activity" EXACT [EC:4.2.1.32] synonym: "tartaric acid dehydrase activity" EXACT [EC:4.2.1.32] synonym: "tartrate dehydratase activity" EXACT [EC:4.2.1.32] xref: EC:4.2.1.32 xref: MetaCyc:LTARTDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008732 name: L-allo-threonine aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-allo-threonine = glycine + acetaldehyde." [MetaCyc:LTAA-RXN, PMID:9228760] subset: gosubset_prok synonym: "L-allo-threonine acetaldehyde-lyase activity" EXACT [] synonym: "LtaA" RELATED [] xref: EC:4.1.2.- xref: MetaCyc:LTAA-RXN is_a: GO:0004793 ! threonine aldolase activity [Term] id: GO:0008733 name: L-arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-arabinose = L-ribulose." [EC:5.3.1.4] subset: gosubset_prok synonym: "L-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.4] synonym: "L-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.4] xref: EC:5.3.1.4 xref: MetaCyc:ARABISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008734 name: L-aspartate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate + O2 = iminosuccinate + H2O2." [EC:1.4.3.16] subset: gosubset_prok synonym: "L-aspartate:oxygen oxidoreductase" EXACT [EC:1.4.3.16] xref: EC:1.4.3.16 xref: MetaCyc:L-ASPARTATE-OXID-RXN xref: MetaCyc:RXN-9772 is_a: GO:0015922 ! aspartate oxidase activity [Term] id: GO:0008735 name: carnitine dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: L-carnitine = 4-(trimethylammonio)but-2-enoate + H2O." [EC:4.2.1.89] subset: gosubset_prok synonym: "L-carnitine dehydratase activity" EXACT [] synonym: "L-carnitine hydro-lyase [4-(trimethylammonio)but-2-enoate-forming]" RELATED [EC:4.2.1.89] synonym: "L-carnitine hydro-lyase activity" EXACT [EC:4.2.1.89] xref: EC:4.2.1.89 xref: MetaCyc:CARNDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008736 name: L-fucose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-fucose = L-fuculose." [EC:5.3.1.25] subset: gosubset_prok synonym: "L-fucose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.25] synonym: "L-fucose ketol-isomerase activity" EXACT [EC:5.3.1.25] xref: EC:5.3.1.25 xref: MetaCyc:FUCISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008737 name: L-fuculokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-fuculose = ADP + L-fuculose 1-phosphate." [EC:2.7.1.51] subset: gosubset_prok synonym: "ATP:L-fuculose 1-phosphotransferase activity" EXACT [EC:2.7.1.51] synonym: "L-fuculokinase (phosphorylating)" EXACT [EC:2.7.1.51] synonym: "L-fuculose kinase activity" EXACT [EC:2.7.1.51] xref: EC:2.7.1.51 xref: MetaCyc:FUCULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008738 name: L-fuculose-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-fuculose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.17] subset: gosubset_prok synonym: "fuculose aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose 1-phosphate aldolase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.17] synonym: "L-fuculose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.17] xref: EC:4.1.2.17 xref: MetaCyc:FUCPALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008740 name: L-rhamnose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnose = L-rhamnulose." [EC:5.3.1.14] subset: gosubset_prok synonym: "L-rhamnose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.14] synonym: "L-rhamnose ketol-isomerase activity" EXACT [EC:5.3.1.14] synonym: "rhamnose isomerase activity" EXACT [EC:5.3.1.14] xref: EC:5.3.1.14 xref: MetaCyc:RHAMNISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008741 name: ribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L(or D)-ribulose = ADP + L(or D)-ribulose 5-phosphate." [EC:2.7.1.16] subset: gosubset_prok synonym: "ATP:L(or D)-ribulose 5-phosphotransferase activity" EXACT [EC:2.7.1.16] synonym: "L-ribulokinase activity" EXACT [] synonym: "ribulokinase (phosphorylating)" EXACT [EC:2.7.1.16] xref: EC:2.7.1.16 xref: MetaCyc:RIBULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008742 name: L-ribulose-phosphate 4-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: L-ribulose 5-phosphate = D-xylose 5-phosphate." [EC:5.1.3.4] subset: gosubset_prok synonym: "AraD" RELATED [EC:5.1.3.4] synonym: "L-ribulose 5-phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] synonym: "L-ribulose-5-phosphate 4-epimerase" BROAD [EC:5.1.3.4] synonym: "L-Ru5P" RELATED [EC:5.1.3.4] synonym: "L-ru5P activity" EXACT [EC:5.1.3.4] synonym: "phosphoribulose isomerase activity" EXACT [EC:5.1.3.4] synonym: "ribulose phosphate 4-epimerase activity" EXACT [EC:5.1.3.4] xref: EC:5.1.3.4 xref: MetaCyc:RIBULPEPIM-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008743 name: L-threonine 3-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-threonine + NAD+ = L-2-amino-3-oxobutanoate + NADH + H+." [EC:1.1.1.103] subset: gosubset_prok synonym: "L-threonine dehydrogenase activity" EXACT [EC:1.1.1.103] synonym: "L-threonine:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.103] synonym: "threonine 3-dehydrogenase activity" BROAD [] synonym: "threonine dehydrogenase activity" EXACT [EC:1.1.1.103] xref: EC:1.1.1.103 xref: MetaCyc:THREODEHYD-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008744 name: L-xylulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-xylulose = ADP + L-xylulose 5-phosphate." [EC:2.7.1.53] subset: gosubset_prok synonym: "ATP:L-xylulose 5-phosphotransferase activity" EXACT [EC:2.7.1.53] synonym: "L-xylulokinase (phosphorylating)" EXACT [EC:2.7.1.53] synonym: "L-xylulose kinase activity" EXACT [EC:2.7.1.53] xref: EC:2.7.1.53 xref: MetaCyc:LYXK-RXN is_a: GO:0004856 ! xylulokinase activity [Term] id: GO:0008745 name: N-acetylmuramoyl-L-alanine amidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the link between N-acetylmuramoyl residues and L-amino acid residues in certain bacterial cell-wall glycopeptides." [EC:3.5.1.28] subset: gosubset_prok synonym: "acetylmuramoyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "murein hydrolase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramic acid L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type I" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramoyl-L-alanine amidase type II" RELATED [EC:3.5.1.28] synonym: "N-acetylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acetylmuramylalanine amidase activity" EXACT [EC:3.5.1.28] synonym: "N-acylmuramyl-L-alanine amidase activity" EXACT [EC:3.5.1.28] synonym: "peptidoglycan amidohydrolase activity" EXACT [EC:3.5.1.28] xref: EC:3.5.1.28 xref: MetaCyc:3.5.1.28-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008746 name: NAD(P) transhydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+." [EC:1.6.1.1, EC:1.6.1.2] subset: gosubset_prok synonym: "energy-linked transhydrogenase" EXACT [EC:1.6.1.1, EC:1.6.1.2] synonym: "H+-thase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADH-NADP-transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD oxidoreductase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH-NAD transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "NADPH:NAD+ transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "nicotinamide adenine dinucleotide (phosphate) transhydrogenase" BROAD [EC:1.6.1.1, EC:1.6.1.2] synonym: "pyridine nucleotide transferase" BROAD [EC:1.6.1.1, EC:1.6.1.2] xref: EC:1.6.1.- xref: Reactome:12610 "NAD(P) transhydrogenase activity" is_a: GO:0016652 ! oxidoreductase activity, acting on NADH or NADPH, NAD or NADP as acceptor [Term] id: GO:0008747 name: N-acetylneuraminate lyase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetylneuraminate = N-acetyl-D-mannosamine + pyruvate." [EC:4.1.3.3] subset: gosubset_prok synonym: "acetylneuraminate lyase activity" EXACT [EC:4.1.3.3] synonym: "acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase (N-acetyl-D-mannosamine-forming)" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminate pyruvate-lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic acid lyase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "N-acetylneuraminic lyase activity" EXACT [EC:4.1.3.3] synonym: "NALase activity" EXACT [EC:4.1.3.3] synonym: "NANA lyase activity" EXACT [EC:4.1.3.3] synonym: "neuraminate aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "neuraminic aldolase activity" EXACT [EC:4.1.3.3] synonym: "NPL" RELATED [EC:4.1.3.3] synonym: "sialate lyase activity" EXACT [EC:4.1.3.3] synonym: "sialic acid aldolase activity" EXACT [EC:4.1.3.3] synonym: "sialic aldolase activity" EXACT [EC:4.1.3.3] xref: EC:4.1.3.3 xref: MetaCyc:ACNEULY-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008748 name: N-ethylmaleimide reductase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0008750 name: NAD(P)+ transhydrogenase (AB-specific) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. The reaction is A-specific (i.e. the pro-R hydrogen is transferred from the 4-position of reduced nicotinamide cofactor) with respect to NAD+ and B-specific (i.e. the pro-S hydrogen is transferred) with respect to NADP+." [EC:1.6.1.2, http://pubs.acs.org/cgi-bin/abstract.cgi/jacsat/1991/113/i07/f-pdf/f_ja00007a002.pdf?sessid=6006l3] subset: gosubset_prok synonym: "NAD(P) transhydrogenase (AB-specific) activity" EXACT [EC:1.6.1.2] synonym: "NADPH:NAD+ oxidoreductase (AB-specific)" EXACT [EC:1.6.1.2] synonym: "pyridine nucleotide transhydrogenase activity" BROAD [EC:1.6.1.2] synonym: "transhydrogenase activity" BROAD [EC:1.6.1.2] xref: EC:1.6.1.2 xref: MetaCyc:1.6.1.2-RXN is_a: GO:0008746 ! NAD(P) transhydrogenase activity [Term] id: GO:0008751 name: NAD(P)H dehydrogenase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it is a redundant grouping term with only one child. is_obsolete: true consider: GO:0016651 [Term] id: GO:0008752 name: FMN reductase activity namespace: molecular_function def: "Catalysis of the reaction: FMNH2 + NAD(P)+ = FMN + NAD(P)H + H+." [EC:1.5.1.29] subset: gosubset_prok synonym: "flavin mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "flavine mononucleotide reductase activity" EXACT [EC:1.5.1.29] synonym: "FMNH2:NAD(P)+ oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H dehydrogenase (FMN) activity" EXACT [] synonym: "NAD(P)H(2) dehydrogenase (FMN) activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H(2):FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-dependent FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H-FMN reductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2 dehydrogenase (FMN)" EXACT [EC:1.5.1.29] synonym: "NAD(P)H2:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:flavin oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "NAD(P)H:FMN oxidoreductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide (reduced nicotinamide adenine dinucleotide (phosphate)) reductase activity" EXACT [EC:1.5.1.29] synonym: "riboflavin mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "riboflavine mononucleotide reductase activity" BROAD [EC:1.5.1.29] synonym: "SsuE" RELATED [EC:1.5.1.29] xref: EC:1.5.1.29 xref: MetaCyc:FMNREDUCT-RXN is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0008753 name: NADPH dehydrogenase (quinone) activity namespace: molecular_function def: "Catalysis of the reaction: NADPH + H+ + acceptor = NADP+ + reduced acceptor." [EC:1.6.99.6] subset: gosubset_prok synonym: "NADPH oxidase" BROAD [EC:1.6.99.6] synonym: "NADPH:(quinone-acceptor) oxidoreductase" EXACT [EC:1.6.99.6] synonym: "reduced nicotinamide adenine dinucleotide phosphate (quinone) dehydrogenase" EXACT [EC:1.6.99.6] xref: EC:1.6.99.6 xref: MetaCyc:NADPH-DEHYDROGENASE-QUINONE-RXN is_a: GO:0003959 ! NADPH dehydrogenase activity [Term] id: GO:0008754 name: O antigen ligase activity namespace: molecular_function is_a: GO:0016874 ! ligase activity [Term] id: GO:0008755 name: O antigen polymerase activity namespace: molecular_function def: "Catalysis of the polymerization of o-antigen chains. O-antigens are tetra and penta saccharide repeat units of the cell walls of Gram-negative bacteria and are a component of lipopolysaccharide." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "O-antigen polymerase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008756 name: o-succinylbenzoate-CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA." [EC:6.2.1.26] subset: gosubset_prok synonym: "2-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoate:CoA ligase (AMP-forming)" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "o-succinylbenzoyl-coenzyme A synthetase activity" EXACT [EC:6.2.1.26] synonym: "OSB-CoA synthetase activity" EXACT [EC:6.2.1.26] synonym: "osb-CoA synthetase activity" EXACT [EC:6.2.1.26] xref: EC:6.2.1.26 xref: MetaCyc:O-SUCCINYLBENZOATE-COA-LIG-RXN is_a: GO:0016405 ! CoA-ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008757 name: S-adenosylmethionine-dependent methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate." [GOC:mah] subset: gosubset_prok synonym: "S-adenosyl methionine-dependent methyltransferase activity" EXACT [] synonym: "SAM-dependent methyltransferase activity" EXACT [] is_a: GO:0008168 ! methyltransferase activity [Term] id: GO:0008758 name: UDP-2,3-diacylglucosamine hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: H2O + UDP-2,3-bis(3-hydroxymyristoyl)glucosamine = 2,3-bis(3-hydroxymyristoyl)-beta-D-glucosaminyl 1-phosphate + UMP." [MetaCyc:LIPIDXSYNTHESIS-RXN, PMID:12000770] subset: gosubset_prok xref: EC:3.6.1.- xref: MetaCyc:LIPIDXSYNTHESIS-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008759 name: UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase activity namespace: molecular_function def: "Catalysis of the removal of an acetyl moiety from the 2-N position of glucosamine in the lipid A precursor UDP-3-O-(R-3-hydroxymyristoyl)-N-acetylglucosamine." [PMID:10026271] subset: gosubset_prok xref: EC:3.5.1.- is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008760 name: UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine." [EC:2.5.1.7] subset: gosubset_prok synonym: "enoylpyruvate transferase activity" EXACT [EC:2.5.1.7] synonym: "MurA transferase activity" NARROW [EC:2.5.1.7] synonym: "phosphoenolpyruvate-UDP-acetylglucosamine-3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-2-acetamido-2-deoxy-D-glucose 2-enoyl-1-carboxyethyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:UDP-N-acetyl-D-glucosamine 1-carboxyvinyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine diphosphate N-acetylglucosamine enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphoenolpyruvate:uridine-5'-diphospho-N-acetyl-2-amino-2-deoxyglucose 3-enolpyruvyltransferase activity" EXACT [EC:2.5.1.7] synonym: "phosphopyruvate-uridine diphosphoacetylglucosamine pyruvatetransferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-UDP-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetyl-glucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvate-uridine diphospho-N-acetylglucosamine transferase activity" EXACT [EC:2.5.1.7] synonym: "pyruvic-uridine diphospho-N-acetylglucosaminyltransferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine 1-carboxyvinyl-transferase activity" EXACT [EC:2.5.1.7] synonym: "UDP-N-acetylglucosamine enoylpyruvyltransferase activity" EXACT [EC:2.5.1.7] xref: EC:2.5.1.7 xref: MetaCyc:UDPNACETYLGLUCOSAMENOLPYRTRANS-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008761 name: UDP-N-acetylglucosamine 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine = UDP-N-acetyl-D-mannosamine." [EC:5.1.3.14] subset: gosubset_prok synonym: "UDP-GlcNAc-2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetyl-D-glucosamine 2-epimerase activity" EXACT [EC:5.1.3.14] synonym: "UDP-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphate-N-acetylglucosamine-2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphospho-N-acetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] synonym: "uridine diphosphoacetylglucosamine 2'-epimerase activity" EXACT [EC:5.1.3.14] xref: EC:5.1.3.14 xref: MetaCyc:UDPGLCNACEPIM-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008762 name: UDP-N-acetylmuramate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+." [EC:1.1.1.158] subset: gosubset_prok synonym: "MurB reductase" RELATED [EC:1.1.1.158] synonym: "UDP-GlcNAc-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylenolpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylglucosamine-enoylpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "UDP-N-acetylmuramate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphospho-N-acetylglucosamine-enolpyruvate reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine diphosphoacetylpyruvoylglucosamine reductase activity" EXACT [EC:1.1.1.158] synonym: "uridine-5'-diphospho-N-acetyl-2-amino-2-deoxy-3-O-lactylglucose:NADP-oxidoreductase activity" EXACT [EC:1.1.1.158] xref: EC:1.1.1.158 xref: MetaCyc:UDPNACETYLMURAMATEDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008763 name: UDP-N-acetylmuramate-L-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl + L-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanine." [EC:6.3.2.8] subset: gosubset_prok synonym: "alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "L-Ala ligase activity" RELATED [EC:6.3.2.8] synonym: "L-alanine-adding enzyme activity" RELATED [EC:6.3.2.8] synonym: "MurC synthetase activity" NARROW [EC:6.3.2.8] synonym: "UDP-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-MurNAc:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramate:L-alanine ligase (ADP-forming)" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "UDP-N-acetylmuramyl:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "UDPMurNAc-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine 5'-diphosphate-N-acetylmuramyl-L-alanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphosphate N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] synonym: "uridine diphospho-N-acetylmuramoylalanine synthetase activity" EXACT [EC:6.3.2.8] synonym: "uridine-diphosphate-N-acetylmuramate:L-alanine ligase activity" EXACT [EC:6.3.2.8] xref: EC:6.3.2.8 xref: MetaCyc:UDP-NACMUR-ALA-LIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008764 name: UDP-N-acetylmuramoylalanine-D-glutamate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanine + D-glutamate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate." [EC:6.3.2.9] subset: gosubset_prok synonym: "D-glutamate ligase activity" RELATED [EC:6.3.2.9] synonym: "D-glutamate-adding enzyme activity" RELATED [EC:6.3.2.9] synonym: "MurD synthetase activity" EXACT [EC:6.3.2.9] synonym: "UDP-Mur-NAC-L-Ala:D-Glu ligase activity" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanine:glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.9] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] synonym: "uridine diphospho-N-acetylmuramoylalanyl-D-glutamate synthetase activity" EXACT [EC:6.3.2.9] xref: EC:6.3.2.9 xref: MetaCyc:UDP-NACMURALA-GLU-LIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008765 name: UDP-N-acetylmuramoylalanyl-D-glutamate-2,6-diaminopimelate ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamate + meso-2,6-diaminoheptanedioate = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate." [EC:6.3.2.13] subset: gosubset_prok synonym: "MurE synthetase activity" RELATED [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:(L)-meso-2,6-diaminoheptanedioate gamma-ligase (ADP-forming)" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamate:meso-2,6-diamino-heptanedioate ligase (ADP-forming) activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelate synthetase activity" EXACT [EC:6.3.2.13] synonym: "UDP-N-acetylmuramyl-tripeptide synthetase activity" EXACT [EC:6.3.2.13] xref: EC:6.3.2.13 xref: MetaCyc:UDP-NACMURALGLDAPLIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008766 name: UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate-D-alanyl-D-alanine ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminoheptanedioate + D-alanyl-D-alanine = ADP + phosphate + UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-6-carboxy-L-lysyl-D-alanyl-D-alanine." [EC:6.3.2.15] comment: Note that EC:6.3.2.15 was deleted from EC as the reaction is performed by UDP-N-acetylmuramoyl-tripeptide-D-alanyl-D-alanine ligase (EC:6.3.2.10). subset: gosubset_prok xref: EC:6.3.2.- xref: MetaCyc:UDP-NACMURALGLDAPAALIG-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008767 name: UDP-galactopyranose mutase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-D-galactopyranose = UDP-D-galacto-1,4-furanose." [EC:5.4.99.9] subset: gosubset_prok synonym: "UDP-D-galactopyranose furanomutase activity" EXACT [EC:5.4.99.9] synonym: "UDPgalactopyranose mutase activity" EXACT [EC:5.4.99.9] xref: EC:5.4.99.9 xref: MetaCyc:GALPMUT-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0008768 name: UDP-sugar diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-sugar + H2O = UMP + sugar 1-phosphate." [EC:3.6.1.45] subset: gosubset_prok synonym: "nucleosidediphosphate-sugar diphosphatase activity" EXACT [EC:3.6.1.45] synonym: "nucleosidediphosphate-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar hydrolase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar pyrophosphatase activity" EXACT [EC:3.6.1.45] synonym: "UDP-sugar sugarphosphohydrolase activity" EXACT [EC:3.6.1.45] xref: EC:3.6.1.45 xref: MetaCyc:UDPSUGARHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008769 name: X-His dipeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Xaa-His dipeptides." [EC:3.4.13.3] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "aminoacyl-histidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "aminoacylhistidine dipeptidase activity" EXACT [EC:3.4.13.3] synonym: "carnosinase activity" RELATED [EC:3.4.13.3] synonym: "dipeptidase M" RELATED [EC:3.4.13.3] synonym: "homocarnosinase activity" RELATED [EC:3.4.13.3] synonym: "Xaa-His dipeptidase activity" EXACT [] xref: EC:3.4.13.3 xref: MetaCyc:3.4.13.3-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0016805 [Term] id: GO:0008770 name: [acyl-carrier-protein] phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: [acyl-carrier protein] + H2O = 4'-phosphopantetheine + apoprotein." [EC:3.1.4.14] subset: gosubset_prok synonym: "[acyl-carrier protein] phosphodiesterase activity" EXACT [] synonym: "[acyl-carrier-protein] 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "ACP hydrolyase activity" EXACT [EC:3.1.4.14] synonym: "ACP phosphodiesterase activity" EXACT [] synonym: "AcpH" RELATED [EC:3.1.4.14] synonym: "acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] synonym: "acyl-carrier-protein phosphodiesterase activity" EXACT [EC:3.1.4.14] synonym: "holo-acyl-carrier-protein 4'-pantetheine-phosphohydrolase activity" EXACT [EC:3.1.4.14] xref: EC:3.1.4.14 xref: MetaCyc:3.1.4.14-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008771 name: [citrate (pro-3S)-lyase] ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate + (citrate (pro-3S)-lyase) (thiol form) = AMP + diphosphate + (citrate (pro-3S)-lyase) (acetyl form)." [EC:6.2.1.22] subset: gosubset_prok synonym: "acetate: SH-acyl-carrier-protein enzyme ligase (AMP)" EXACT [EC:6.2.1.22] synonym: "acetate:citrate-(pro-3S)-lyase(thiol-form) ligase (AMP-forming)" BROAD [EC:6.2.1.22] synonym: "acetate:HS-citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate (pro-3S)-lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase ligase activity" EXACT [EC:6.2.1.22] synonym: "citrate lyase synthetase activity" EXACT [EC:6.2.1.22] xref: EC:6.2.1.22 xref: MetaCyc:CITC-RXN is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008772 name: [isocitrate dehydrogenase (NADP+)] kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (isocitrate dehydrogenase (NADP)) = ADP + (isocitrate dehydrogenase (NADP)) phosphate." [EC:2.7.11.5] subset: gosubset_prok synonym: "ATP:isocitrate dehydrogenase (NADP+) phosphotransferase activity" EXACT [EC:2.7.11.5] synonym: "ICDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase activity" EXACT [EC:2.7.11.5] synonym: "IDH kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "IDH-K/P" RELATED [EC:2.7.11.5] synonym: "IDHK/P" RELATED [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase (NADP+) kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase (phosphorylating) activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase activity" EXACT [EC:2.7.11.5] synonym: "isocitrate dehydrogenase kinase/phosphatase activity" EXACT [EC:2.7.11.5] synonym: "STK3" RELATED [EC:2.7.11.5] xref: EC:2.7.11.5 xref: MetaCyc:PHOSICITDEHASE-RXN is_a: GO:0004672 ! protein kinase activity [Term] id: GO:0008773 name: [protein-PII] uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UTP + (protein-PII) = diphosphate + uridylyl-(protein-PII)." [EC:2.7.7.59] subset: gosubset_prok synonym: "PII uridylyl-transferase activity" EXACT [EC:2.7.7.59] synonym: "protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] synonym: "uridyl removing enzyme" RELATED [EC:2.7.7.59] synonym: "uridylyl removing enzyme activity" BROAD [EC:2.7.7.59] synonym: "UTP:[protein-PII] uridylyltransferase activity" EXACT [] synonym: "UTP:protein-PII uridylyltransferase activity" EXACT [EC:2.7.7.59] xref: EC:2.7.7.59 xref: MetaCyc:URITRANS-RXN is_a: GO:0070569 ! uridylyltransferase activity [Term] id: GO:0008774 name: acetaldehyde dehydrogenase (acetylating) activity namespace: molecular_function def: "Catalysis of the reaction: acetaldehyde + CoA + NAD+ = acetyl-CoA + NADH + H+." [EC:1.2.1.10] subset: gosubset_prok synonym: "acetaldehyde:NAD+ oxidoreductase (CoA-acetylating)" EXACT [EC:1.2.1.10] synonym: "acylating acetaldehyde dehydrogenase activity" EXACT [EC:1.2.1.10] synonym: "ADA" RELATED [EC:1.2.1.10] synonym: "aldehyde dehydrogenase (acylating) activity" EXACT [EC:1.2.1.10] synonym: "DmpF" RELATED [EC:1.2.1.10] xref: EC:1.2.1.10 xref: MetaCyc:ACETALD-DEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008775 name: acetate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-CoA + acetate = a fatty acid anion + acetyl-CoA." [EC:2.8.3.8] subset: gosubset_prok synonym: "acetate coenzyme A-transferase activity" EXACT [EC:2.8.3.8] synonym: "acetyl-CoA:acetoacetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "acyl-CoA:acetate CoA-transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] synonym: "butyryl coenzyme A transferase activity" EXACT [EC:2.8.3.8] synonym: "succinyl-CoA:acetate CoA transferase activity" EXACT [EC:2.8.3.8] xref: EC:2.8.3.8 xref: MetaCyc:ACECOATRANS-RXN xref: UM-BBD_enzymeID:e0012 is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008776 name: acetate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + acetate = ADP + acetyl phosphate." [EC:2.7.2.1] subset: gosubset_prok synonym: "acetate kinase (phosphorylating) activity" EXACT [EC:2.7.2.1] synonym: "acetic kinase activity" EXACT [EC:2.7.2.1] synonym: "acetokinase activity" EXACT [EC:2.7.2.1] synonym: "AckA" RELATED [EC:2.7.2.1] synonym: "AK activity" EXACT [EC:2.7.2.1] synonym: "ATP:acetate phosphotransferase activity" EXACT [EC:2.7.2.1] xref: EC:2.7.2.1 xref: MetaCyc:ACETATEKIN-RXN xref: UM-BBD_enzymeID:e0031 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008777 name: acetylornithine deacetylase activity namespace: molecular_function def: "Catalysis of the reaction: N2-acetyl-L-ornithine + H2O = acetate + L-ornithine." [EC:3.5.1.16] subset: gosubset_prok synonym: "2-N-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] synonym: "acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N-acetylornithinase activity" BROAD [EC:3.5.1.16] synonym: "N2-acetyl-L-ornithine amidohydrolase activity" EXACT [EC:3.5.1.16] xref: EC:3.5.1.16 xref: MetaCyc:ACETYLORNDEACET-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides is_a: GO:0019213 ! deacetylase activity [Term] id: GO:0008779 name: acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acyl-[acyl-carrier protein] + O-(2-acyl-sn-glycero-3-phospho)ethanolamine = [acyl-carrier protein] + O-(1-beta-acyl-2-acyl-sn-glycero-3-phospho)ethanolamine." [EC:2.3.1.40] synonym: "acyl-[acyl-carrier protein]-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-phospholipid O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-phospholipid O-acyltransferase activity" EXACT [EC:2.3.1.40] synonym: "acyl-acyl-carrier-protein:O-(2-acyl-sn-glycero-3-phospho)-ethanolamine O-acyltransferase activity" EXACT [EC:2.3.1.40] xref: EC:2.3.1.40 xref: MetaCyc:ACYLGPEACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008780 name: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: (R)-3-hydroxytetradecanoyl-[acyl-carrier protein] + UDP-N-acetylglucosamine = [acyl-carrier protein] + UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine." [EC:2.3.1.129] subset: gosubset_prok synonym: "(R)-3-hydroxytetradecanoyl-acyl-carrier-protein:UDP-N-acetylglucosamine 3-O-(3-hydroxytetradecanoyl)transferase activity" EXACT [EC:2.3.1.129] synonym: "acyl-[acyl-carrier protein]-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-ACP-UDP-N-acetylglucosamine O-acyltransferase activity" EXACT [] synonym: "acyl-acyl-carrier-protein-UDP-N-acetylglucosamine O-acyltransferase" BROAD [EC:2.3.1.129] synonym: "UDP-N-acetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] synonym: "uridine diphosphoacetylglucosamine acyltransferase activity" EXACT [EC:2.3.1.129] xref: EC:2.3.1.129 xref: MetaCyc:UDPNACETYLGLUCOSAMACYLTRANS-RXN is_a: GO:0008374 ! O-acyltransferase activity [Term] id: GO:0008781 name: N-acylneuraminate cytidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: CTP + N-acylneuraminate = diphosphate + CMP-N-acylneuraminate." [EC:2.7.7.43] subset: gosubset_prok synonym: "acetylneuraminate cytidylyltransferase activity" EXACT [EC:2.7.7.43] synonym: "acylneuraminate cytidyltransferase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NANA synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-Neu5Ac synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-NeuNAc synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate diphosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "CMP-sialic synthetase activity" EXACT [EC:2.7.7.43] synonym: "CTP:N-acylneuraminate cytidylyltransferase activity" EXACT [] synonym: "cytidine 5'-monophospho-N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5'-monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine 5-monophosphate N-acetylneuraminic acid synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphoacetylneuraminic synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate pyrophosphorylase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialate synthetase activity" EXACT [EC:2.7.7.43] synonym: "cytidine monophosphosialic acid synthetase activity" EXACT [EC:2.7.7.43] xref: EC:2.7.7.43 xref: MetaCyc:ACYLNEURAMINATE-CYTIDYLYLTRANSFERASE-RXN is_a: GO:0070567 ! cytidylyltransferase activity [Term] id: GO:0008782 name: adenosylhomocysteine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenine + S-D-ribosyl-L-homocysteine." [EC:3.2.2.9] subset: gosubset_prok synonym: "5'-methyladenosine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "AdoHcy/MTA nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosyl-L-homocysteine homocysteinylribohydrolase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine hydrolase activity" BROAD [EC:3.2.2.9] synonym: "S-adenosylhomocysteine nucleosidase activity" EXACT [EC:3.2.2.9] synonym: "S-adenosylhomocysteine/5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.9] xref: EC:3.2.2.9 xref: MetaCyc:ADENOSYLHOMOCYSTEINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008783 name: agmatinase activity namespace: molecular_function def: "Catalysis of the reaction: agmatine + H2O = putrescine + urea." [EC:3.5.3.11] subset: gosubset_prok synonym: "agmatine amidinohydrolase" BROAD [EC:3.5.3.11] synonym: "agmatine ureohydrolase activity" EXACT [EC:3.5.3.11] synonym: "SpeB" RELATED [EC:3.5.3.11] xref: EC:3.5.3.11 xref: MetaCyc:AGMATIN-RXN xref: Reactome:26116 "agmatinase activity" is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0008784 name: alanine racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-alanine = D-alanine." [EC:5.1.1.1] subset: gosubset_prok synonym: "L-alanine racemase activity" EXACT [EC:5.1.1.1] xref: EC:5.1.1.1 xref: MetaCyc:ALARACECAT-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008785 name: alkyl hydroperoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: octane hydroperoxide + NADH + H+ = H2O + NAD+ + 1-octanol." [UM-BBD_enzymeID:e0429] subset: gosubset_prok xref: EC:1.8.1.- xref: UM-BBD_enzymeID:e0429 is_a: GO:0016668 ! oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor [Term] id: GO:0008786 name: allose 6-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-allose-6-phosphate = D-allulose-6-phosphate." [MetaCyc:RXN0-303] xref: EC:5.3.1.- xref: MetaCyc:RXN0-303 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008787 name: allose kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-allose = ADP + D-allose 6-phosphate." [EC:2.7.1.55] subset: gosubset_prok synonym: "allokinase (phosphorylating)" EXACT [EC:2.7.1.55] synonym: "allokinase activity" EXACT [EC:2.7.1.55] synonym: "ATP:D-allose 6-phosphotransferase activity" EXACT [EC:2.7.1.55] synonym: "D-allokinase activity" EXACT [EC:2.7.1.55] synonym: "D-allose-6-kinase activity" EXACT [EC:2.7.1.55] xref: EC:2.7.1.55 xref: MetaCyc:ALLOSE-KINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008788 name: alpha,alpha-phosphotrehalase activity namespace: molecular_function def: "Catalysis of the reaction: alpha,alpha-trehalose 6-phosphate + H2O = D-glucose + D-glucose 6-phosphate." [EC:3.2.1.93] subset: gosubset_prok synonym: "alpha,alpha-trehalose-6-phosphate phosphoglucohydrolase activity" EXACT [EC:3.2.1.93] synonym: "phosphotrehalase activity" EXACT [EC:3.2.1.93] synonym: "trehalose-6-phosphate hydrolase activity" EXACT [EC:3.2.1.93] xref: EC:3.2.1.93 xref: MetaCyc:TRE6PHYDRO-RXN is_a: GO:0015927 ! trehalase activity [Term] id: GO:0008789 name: altronate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.7] subset: gosubset_prok synonym: "D-altronate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.7] synonym: "D-altronate hydro-lyase activity" EXACT [EC:4.2.1.7] xref: EC:4.2.1.7 xref: MetaCyc:ALTRODEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008790 name: arabinose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-arabinose = D-ribulose." [EC:5.3.1.3] synonym: "D-arabinose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose isomerase activity" NARROW [EC:5.3.1.3] synonym: "D-arabinose ketol-isomerase activity" EXACT [EC:5.3.1.3] synonym: "D-arabinose(L-fucose) isomerase activity" EXACT [EC:5.3.1.3] xref: EC:5.3.1.3 xref: MetaCyc:DARABISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008791 name: arginine N-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-arginine = CoA + N2-succinyl-L-arginine." [EC:2.3.1.109] subset: gosubset_prok synonym: "AOST activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N(2)-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine and ornithine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "arginine succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "AST activity" EXACT [EC:2.3.1.109] synonym: "AstA" RELATED [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine 2-N-succinyltransferase activity" EXACT [EC:2.3.1.109] synonym: "succinyl-CoA:L-arginine N2-succinyltransferase activity" EXACT [EC:2.3.1.109] xref: EC:2.3.1.109 xref: MetaCyc:ARGININE-N-SUCCINYLTRANSFERASE-RXN is_a: GO:0016749 ! N-succinyltransferase activity [Term] id: GO:0008792 name: arginine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-arginine = agmatine + CO2." [EC:4.1.1.19] subset: gosubset_prok synonym: "L-arginine carboxy-lyase (agmatine-forming)" EXACT [EC:4.1.1.19] synonym: "L-arginine carboxy-lyase activity" EXACT [EC:4.1.1.19] synonym: "SpeA" RELATED [EC:4.1.1.19] xref: EC:4.1.1.19 xref: MetaCyc:ARGDECARBOX-RXN xref: Reactome:26125 "arginine decarboxylase activity" is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008793 name: aromatic-amino-acid:2-oxoglutarate aminotransferase activity namespace: molecular_function def: "Catalysis of the reaction: an aromatic amino acid + 2-oxoglutarate = an aromatic oxo acid + L-glutamate." [EC:2.6.1.57] subset: gosubset_prok synonym: "ArAT" RELATED [EC:2.6.1.57] synonym: "aromatic amino acid aminotransferase activity" EXACT [EC:2.6.1.57] synonym: "aromatic amino acid transferase activity" EXACT [] synonym: "aromatic aminotransferase activity" EXACT [] synonym: "aromatic-amino-acid transaminase activity" EXACT [EC:2.6.1.57] xref: EC:2.6.1.57 xref: MetaCyc:2.6.1.57-RXN xref: UM-BBD_enzymeID:e0142 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0008794 name: arsenate reductase (glutaredoxin) activity namespace: molecular_function def: "Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione." [EC:1.20.4.1, GOC:kd, PMID:10593884] subset: gosubset_prok synonym: "glutharedoxin:arsenate oxidoreductase activity" EXACT [EC:1.20.4.1] xref: EC:1.20.4.1 xref: MetaCyc:RXN-982 xref: UM-BBD_enzymeID:e0261 is_a: GO:0030611 ! arsenate reductase activity is_a: GO:0030614 ! oxidoreductase activity, acting on phosphorus or arsenic in donors, with disulfide as acceptor [Term] id: GO:0008795 name: NAD+ synthase activity namespace: molecular_function alt_id: GO:0008749 alt_id: GO:0016965 def: "Catalysis of the reaction: ATP + deamido-NAD+ + NH3 = AMP + diphosphate + NAD+." [EC:6.3.1.5] subset: gosubset_prok synonym: "deamido-NAD+:ammonia ligase (AMP-forming)" EXACT [EC:6.3.1.5] synonym: "diphosphopyridine nucleotide synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD synthase (AMP-forming)" EXACT [] synonym: "NAD synthase activity" EXACT [] synonym: "NAD synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD(+) synthetase activity" EXACT [EC:6.3.1.5] synonym: "NAD+ synthetase activity" EXACT [EC:6.3.1.5] synonym: "nicotinamide adenine dinucleotide synthetase activity" EXACT [EC:6.3.1.5] xref: EC:6.3.1.5 xref: MetaCyc:NAD-SYNTH-NH3-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008796 name: bis(5'-nucleosyl)-tetraphosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of P(1),P(4)-bis(5'-nucleosyl)tetraphosphate into two nucleotides." [GOC:ai] subset: gosubset_prok xref: EC:3.6.1.- is_a: GO:0004551 ! nucleotide diphosphatase activity [Term] id: GO:0008797 name: aspartate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate = fumarate + NH3." [EC:4.3.1.1] subset: gosubset_prok synonym: "aspartase activity" EXACT [EC:4.3.1.1] synonym: "fumaric aminase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartase activity" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase (fumarate-forming)" EXACT [EC:4.3.1.1] synonym: "L-aspartate ammonia-lyase activity" EXACT [EC:4.3.1.1] xref: EC:4.3.1.1 xref: MetaCyc:ASPARTASE-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008798 name: beta-aspartyl-peptidase activity namespace: molecular_function def: "Catalysis of the cleavage of a beta-linked aspartic residue from the N-terminus of a polypeptide." [EC:3.4.19.5] subset: gosubset_prok synonym: "beta-aspartyl dipeptidase activity" EXACT [EC:3.4.19.5] synonym: "beta-aspartyl peptidase activity" EXACT [EC:3.4.19.5] xref: EC:3.4.19.5 xref: MetaCyc:3.4.19.5-RXN is_a: GO:0008242 ! omega peptidase activity [Term] id: GO:0008800 name: beta-lactamase activity namespace: molecular_function def: "Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid." [EC:3.5.2.6] subset: gosubset_prok synonym: "ampicillinase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactam hydrolase activity" EXACT [EC:3.5.2.6] synonym: "beta-lactamase A, B, C" RELATED [EC:3.5.2.6] synonym: "beta-lactamase AME I" RELATED [EC:3.5.2.6] synonym: "beta-lactamase I-III" RELATED [EC:3.5.2.6] synonym: "cephalosporin-beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "exopenicillinase activity" EXACT [EC:3.5.2.6] synonym: "neutrapen" RELATED [EC:3.5.2.6] synonym: "penicillin amido-beta-lactamhydrolase activity" EXACT [EC:3.5.2.6] synonym: "penicillin beta-lactamase activity" EXACT [EC:3.5.2.6] synonym: "penicillinase I, II" RELATED [EC:3.5.2.6] xref: EC:3.5.2.6 xref: MetaCyc:BETA-LACTAMASE-RXN is_a: GO:0016812 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides [Term] id: GO:0008801 name: beta-phosphoglucomutase activity namespace: molecular_function def: "Catalysis of the reaction: beta-D-glucose 1-phosphate = beta-D-glucose 6-phosphate." [EC:5.4.2.6] subset: gosubset_prok synonym: "beta-D-glucose 1,6-phosphomutase activity" EXACT [EC:5.4.2.6] xref: EC:5.4.2.6 xref: MetaCyc:BETA-PHOSPHOGLUCOMUTASE-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008802 name: betaine-aldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+." [EC:1.2.1.8] subset: gosubset_prok synonym: "BADH activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde dehydrogenase activity" EXACT [EC:1.2.1.8] synonym: "betaine aldehyde oxidase activity" EXACT [EC:1.2.1.8] synonym: "betaine-aldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.8] synonym: "BetB" RELATED [EC:1.2.1.8] xref: EC:1.2.1.8 xref: MetaCyc:BADH-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008803 name: bis(5'-nucleosyl)-tetraphosphatase (symmetrical) activity namespace: molecular_function def: "Catalysis of the reaction: P(1),P(4)-bis(5'-nucleosyl)tetraphosphate + H2O = 2 NDP." [EC:3.6.1.41, PMID:6317672] subset: gosubset_prok synonym: "1-P,4-P-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "adenosine tetraphosphate phosphodiesterase activity" EXACT [EC:3.6.1.41] synonym: "Ap(4)A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "Ap4A hydrolase activity" BROAD [EC:3.6.1.41] synonym: "bis(5'-adenosyl) tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P(1),P(4)-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphatase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine 5',5'''-P1,P4-tetraphosphate pyrophosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine polyphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosine tetraphosphatase (symmetrical)" NARROW [] synonym: "diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] synonym: "diadenosinetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphatase (symmetrical) activity" EXACT [EC:3.6.1.41] synonym: "dinucleosidetetraphosphate (symmetrical)" RELATED [EC:3.6.1.41] synonym: "P1,P4-bis(5'-nucleosyl)-tetraphosphate nucleosidebisphosphohydrolase activity" EXACT [EC:3.6.1.41] synonym: "symmetrical diadenosine tetraphosphate hydrolase activity" EXACT [EC:3.6.1.41] xref: EC:3.6.1.41 xref: MetaCyc:3.6.1.41-RXN is_a: GO:0008796 ! bis(5'-nucleosyl)-tetraphosphatase activity [Term] id: GO:0008804 name: carbamate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + NH3 + CO2 = ADP + carbamoyl phosphate." [EC:2.7.2.2] subset: gosubset_prok synonym: "ATP:carbamate phosphotransferase activity" EXACT [EC:2.7.2.2] synonym: "carbamoyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "carbamyl phosphokinase activity" EXACT [EC:2.7.2.2] synonym: "CKase activity" EXACT [EC:2.7.2.2] xref: EC:2.7.2.2 xref: MetaCyc:CARBAMATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008805 name: carbon-monoxide oxygenase activity namespace: molecular_function alt_id: GO:0018999 alt_id: GO:0047767 def: "Catalysis of the reaction: CO + H2O + ferrocytochrome b-561 = CO2 + 2 H+ + 2 ferricytochrome b-561." [EC:1.2.2.4] synonym: "carbon monoxide oxidase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide oxygenase (cytochrome b-561) activity" NARROW [EC:1.2.2.4] synonym: "carbon monoxide oxygenase activity" EXACT [] synonym: "carbon monoxide,water:cytochrome b-561 oxidoreductase activity" EXACT [EC:1.2.2.4] synonym: "carbon monoxide:methylene blue oxidoreductase activity" NARROW [EC:1.2.2.4] synonym: "carbon-monoxide dehydrogenase (cytochrome b-561)" EXACT [EC:1.2.2.4] synonym: "cytochrome b561" NARROW [] xref: EC:1.2.2.4 xref: MetaCyc:1.2.2.4-RXN xref: UM-BBD_enzymeID:e0180 xref: Wikipedia:Carbon-monoxide_dehydrogenase_(cytochrome_b-561) is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008806 name: carboxymethylenebutenolidase activity namespace: molecular_function alt_id: GO:0018735 def: "Catalysis of the reaction: 4-carboxymethylenebut-2-en-4-olide + H2O = 4 oxohex-2-enedioate." [EC:3.1.1.45] subset: gosubset_prok synonym: "4-carboxymethylenebut-2-en-4-olide lactonohydrolase activity" EXACT [EC:3.1.1.45] synonym: "carboxymethylene butenolide hydrolase activity" EXACT [EC:3.1.1.45] synonym: "dienelactone hydrolase activity" EXACT [EC:3.1.1.45] synonym: "maleylacetate enol-lactonase activity" EXACT [EC:3.1.1.45] xref: EC:3.1.1.45 xref: MetaCyc:CARBOXYMETHYLENEBUTENOLIDASE-RXN xref: UM-BBD_enzymeID:e0066 is_a: GO:0004091 ! carboxylesterase activity [Term] id: GO:0008807 name: carboxyvinyl-carboxyphosphonate phosphorylmutase activity namespace: molecular_function def: "Catalysis of the reaction: 1-carboxyvinyl carboxyphosphonate = 3-(hydrohydroxyphosphoryl)pyruvate + CO2." [EC:2.7.8.23] subset: gosubset_prok synonym: "1-carboxyvinyl carboxyphosphonate phosphorylmutase (decarboxylating)" EXACT [EC:2.7.8.23] synonym: "carboxyphosphonoenolpyruvate phosphonomutase activity" EXACT [EC:2.7.8.23] synonym: "CPEP phosphonomutase activity" EXACT [EC:2.7.8.23] xref: EC:2.7.8.23 xref: MetaCyc:2.7.8.23-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008808 name: cardiolipin synthase activity namespace: molecular_function def: "Phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol." [GOC:jl] subset: gosubset_prok synonym: "cardiolipin synthetase activity" BROAD [] synonym: "diphosphatidylglycerol synthase activity" EXACT [] xref: EC:2.7.8.- xref: MetaCyc:CARDIOLIPSYN-RXN is_a: GO:0030572 ! phosphatidyltransferase activity [Term] id: GO:0008809 name: carnitine racemase activity namespace: molecular_function def: "Catalysis of the reaction: D-carnitine = L-carnitine." [MetaCyc:CARNRACE-RXN] xref: EC:5.1.-.- xref: MetaCyc:CARNRACE-RXN is_a: GO:0016856 ! racemase and epimerase activity, acting on hydroxy acids and derivatives [Term] id: GO:0008810 name: cellulase activity namespace: molecular_function def: "Catalysis of the endohydrolysis of 1,4-beta-D-glucosidic linkages in cellulose, lichenin and cereal beta-D-glucans." [EC:3.2.1.4] subset: gosubset_prok synonym: "1,4-(1,3;1,4)-beta-D-glucan 4-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "9.5 cellulase activity" EXACT [EC:3.2.1.4] synonym: "alkali cellulase activity" EXACT [EC:3.2.1.4] synonym: "avicelase activity" BROAD [EC:3.2.1.4] synonym: "beta-1,4-endoglucan hydrolase activity" EXACT [EC:3.2.1.4] synonym: "beta-1,4-glucanase activity" BROAD [EC:3.2.1.4] synonym: "carboxymethyl cellulase activity" NARROW [EC:3.2.1.4] synonym: "celluase A" RELATED [EC:3.2.1.4] synonym: "celludextrinase activity" EXACT [EC:3.2.1.4] synonym: "cellulase A 3" RELATED [EC:3.2.1.4] synonym: "cellulosin AP" RELATED [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-D-glucanohydrolase activity" EXACT [EC:3.2.1.4] synonym: "endo-1,4-beta-glucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase activity" EXACT [EC:3.2.1.4] synonym: "endoglucanase D" RELATED [EC:3.2.1.4] synonym: "pancellase SS" RELATED [EC:3.2.1.4] xref: EC:3.2.1.4 xref: MetaCyc:RXN-2043 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0008811 name: chloramphenicol O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + chloramphenicol = CoA + chloramphenicol 3-acetate." [EC:2.3.1.28] subset: gosubset_prok synonym: "acetyl-CoA:chloramphenicol 3-O-acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "CAT I" RELATED [EC:2.3.1.28] synonym: "CAT II" RELATED [EC:2.3.1.28] synonym: "CAT III" RELATED [EC:2.3.1.28] synonym: "chloramphenicol acetylase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol acetyltransferase activity" EXACT [EC:2.3.1.28] synonym: "chloramphenicol transacetylase activity" EXACT [EC:2.3.1.28] xref: EC:2.3.1.28 xref: MetaCyc:CHLORAMPHENICOL-O-ACETYLTRANSFERASE-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008812 name: choline dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: choline + acceptor = betaine aldehyde + reduced acceptor." [EC:1.1.99.1] subset: gosubset_prok synonym: "choline oxidase activity" BROAD [EC:1.1.99.1] synonym: "choline-cytochrome c reductase activity" RELATED [EC:1.1.99.1] synonym: "choline:(acceptor) 1-oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.1] synonym: "choline:acceptor 1-oxidoreductase activity" EXACT [EC:1.1.99.1] xref: EC:1.1.99.1 xref: MetaCyc:CHD-RXN is_a: GO:0016614 ! oxidoreductase activity, acting on CH-OH group of donors [Term] id: GO:0008813 name: chorismate lyase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = 4-hydroxybenzoate + pyruvate." [EC:4.1.3.40, IMG:00552, MetaCyc:CHORPYRLY-RXN] subset: gosubset_prok synonym: "4-hydroxybenzoate synthetase activity" EXACT [] synonym: "chorismate pyruvate lyase activity" EXACT [] synonym: "chorismate pyruvate-lyase (4-hydroxybenzoate-forming) activity" EXACT [EC:4.1.3.40] synonym: "CL" RELATED [EC:4.1.3.40] synonym: "CPL" RELATED [EC:4.1.3.40] synonym: "UbiC" RELATED [EC:4.1.3.40] xref: EC:4.1.3.40 xref: MetaCyc:CHORPYRLY-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008814 name: citrate CoA-transferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + citrate = acetate + (3S)-citryl-CoA." [EC:2.8.3.10] subset: gosubset_prok synonym: "acetyl-CoA:citrate CoA-transferase activity" EXACT [EC:2.8.3.10] xref: EC:2.8.3.10 xref: MetaCyc:CITTRANS-RXN is_a: GO:0008410 ! CoA-transferase activity [Term] id: GO:0008815 name: citrate (pro-3S)-lyase activity namespace: molecular_function def: "Catalysis of the reaction: citrate = acetate + oxaloacetate." [EC:4.1.3.6] subset: gosubset_prok synonym: "citrase activity" EXACT [EC:4.1.3.6] synonym: "citratase activity" EXACT [EC:4.1.3.6] synonym: "citrate aldolase activity" EXACT [EC:4.1.3.6] synonym: "citrate lyase activity" EXACT [] synonym: "citrate oxaloacetate-lyase [(pro-3S)-CH2COO-->acetate]" RELATED [EC:4.1.3.6] synonym: "citrate oxaloacetate-lyase activity" EXACT [EC:4.1.3.6] synonym: "citric aldolase activity" EXACT [EC:4.1.3.6] synonym: "citridesmolase activity" EXACT [EC:4.1.3.6] synonym: "citritase activity" EXACT [EC:4.1.3.6] xref: EC:4.1.3.6 xref: MetaCyc:CITLY-RXN xref: Reactome:26375 "citrate (pro-3S)-lyase activity" is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008816 name: citryl-CoA lyase activity namespace: molecular_function def: "Catalysis of the reaction: (3S)-citryl-CoA = acetyl-CoA + oxaloacetate." [EC:4.1.3.34] subset: gosubset_prok synonym: "(3S)-citryl-CoA oxaloacetate-lyase (acetyl-CoA-forming)" EXACT [EC:4.1.3.34] synonym: "(3S)-citryl-CoA oxaloacetate-lyase activity" EXACT [EC:4.1.3.34] xref: EC:4.1.3.34 xref: MetaCyc:CITRYLY-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008817 name: cob(I)yrinic acid a,c-diamide adenosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + cob(I)alamin + H2O = phosphate + diphosphate + adenosylcobalamin." [EC:2.5.1.17] subset: gosubset_prok synonym: "aquacob(I)alamin adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "aquocob(I)alamin vitamin B12s adenosyltransferase activity" RELATED [EC:2.5.1.17] synonym: "ATP:cob(I)alamin Co-beta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)alamin cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:cob(I)yrinic acid-a,c-diamide cobeta-adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "ATP:corrinoid adenosyltransferase activity" EXACT [EC:2.5.1.17] synonym: "cob(I)alamin adenosyltransferase activity" EXACT [] synonym: "CobA" RELATED [EC:2.5.1.17] synonym: "vitamin B12s adenosyltransferase activity" EXACT [EC:2.5.1.17] xref: EC:2.5.1.17 xref: MetaCyc:COBALADENOSYLTRANS-RXN is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0008818 name: cobalamin 5'-phosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-GDP + alpha-ribazole-5'-phosphate = adenosylcobalamin-5'-phosphate + GMP." [MetaCyc:COBALAMIN5PSYN-RXN] subset: gosubset_prok xref: MetaCyc:COBALAMIN5PSYN-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008819 name: cobinamide kinase activity namespace: molecular_function def: "Catalysis of the reaction: cobinamide + ATP = cobinamide phosphate + ADP. This reaction is the phosphorylation of the hydroxyl group of the 1-amino-2-propanol residue of cobinamide, in the presence of ATP, to form cobinamide phosphate." [http://www.mblab.gla.ac.uk/, PMID:1655696] subset: gosubset_prok xref: EC:2.7.1.- is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008820 name: cobinamide phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: adenosylcobinamide-phosphate + GTP = adenosylcobinamide-GDP + diphosphate." [MetaCyc:COBINPGUANYLYLTRANS-RXN] subset: gosubset_prok synonym: "GTP:cobinamide phosphate guanylyltransferase activity" EXACT [] xref: MetaCyc:COBINPGUANYLYLTRANS-RXN is_a: GO:0016740 ! transferase activity [Term] id: GO:0008821 name: crossover junction endodeoxyribonuclease activity namespace: molecular_function alt_id: GO:0008844 def: "Catalysis of the endonucleolytic cleavage at a junction such as a reciprocal single-stranded crossover between two homologous DNA duplexes (Holliday junction)." [EC:3.1.22.4] synonym: "crossover junction endoribonuclease activity" EXACT [] synonym: "cruciform-cutting endonuclease activity" EXACT [EC:3.1.22.-] synonym: "endo X3" RELATED [EC:3.1.22.4] synonym: "Endo X3 activity" NARROW [EC:3.1.22.-] synonym: "endodeoxyribonuclease RUS activity" EXACT [] synonym: "endonuclease RuvC activity" NARROW [EC:3.1.22.-] synonym: "endonuclease VII activity" NARROW [EC:3.1.22.-] synonym: "endonuclease X3 activity" NARROW [EC:3.1.22.-] synonym: "Hje endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction endonuclease CCE1 activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction nuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "Holliday junction-cleaving endonuclease activity" EXACT [EC:3.1.22.-] synonym: "Holliday junction-resolving endoribonuclease activity" NARROW [EC:3.1.22.-] synonym: "resolving enzyme CCE1 activity" NARROW [EC:3.1.22.-] synonym: "RusA endonuclease activity" NARROW [EC:3.1.22.-] synonym: "RusA holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "RusA Holliday junction resolvase activity" NARROW [EC:3.1.22.-] synonym: "RuvC endonuclease activity" NARROW [EC:3.1.22.-] synonym: "SpCCe1 holliday junction resolvase" NARROW [EC:3.1.22.4] synonym: "SpCCe1 Holliday junction resolvase activity" NARROW [EC:3.1.22.-] xref: EC:3.1.22.- xref: EC:3.1.22.4 xref: MetaCyc:3.1.22.4-RXN is_a: GO:0016889 ! endodeoxyribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008822 name: crotonobetaine/carnitine-CoA ligase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a bifunctional gene product. is_obsolete: true replaced_by: GO:0051108 replaced_by: GO:0051109 [Term] id: GO:0008823 name: cupric reductase activity namespace: molecular_function xref: EC:1.16.1.- is_a: GO:0016723 ! oxidoreductase activity, oxidizing metal ions, NAD or NADP as acceptor [Term] id: GO:0008824 name: cyanate hydratase activity namespace: molecular_function def: "Catalysis of the reaction: cyanate (NCO-) + H2O = carbamate (H2N-CO-O-)." [EC:4.2.1.104] comment: Note that this function was formerly EC:4.3.99.1. subset: gosubset_prok synonym: "carbamate hydro-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanase activity" EXACT [] synonym: "cyanate aminohydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate C-N-lyase activity" EXACT [EC:4.2.1.104] synonym: "cyanate hydrolase activity" EXACT [EC:4.2.1.104] synonym: "cyanate lyase activity" EXACT [] xref: EC:4.2.1.104 xref: MetaCyc:R524-RXN xref: UM-BBD_enzymeID:e0396 is_a: GO:0016840 ! carbon-nitrogen lyase activity [Term] id: GO:0008825 name: cyclopropane-fatty-acyl-phospholipid synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + phospholipid olefinic fatty acid = S-adenosyl-L-homocysteine + phospholipid cyclopropane fatty acid." [EC:2.1.1.79] subset: gosubset_prok synonym: "CFA synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane fatty acid synthetase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthase activity" EXACT [EC:2.1.1.79] synonym: "cyclopropane synthetase activity" BROAD [EC:2.1.1.79] synonym: "S-adenosyl-L-methionine:unsaturated-phospholipid methyltransferase (cyclizing)" EXACT [EC:2.1.1.79] synonym: "unsaturated-phospholipid methyltransferase activity" BROAD [EC:2.1.1.79] xref: EC:2.1.1.79 xref: MetaCyc:2.1.1.79-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008826 name: cysteine sulfinate desulfinase activity namespace: molecular_function def: "Catalysis of the reaction: 3-sulfinoalanine = L-alanine + SO3(2-)." [MetaCyc:RXN0-279] synonym: "cysteine sulphinate desulphinase activity" EXACT [] xref: EC:4.4.1.- xref: MetaCyc:RXN0-279 is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0008827 name: cytochrome o ubiquinol oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ubiquinol + O2 = ubiquinone + 2 H2R; cytochrome O is the electron acceptor." [GOC:mah, MetaCyc:CYT-UBIQUINOL-OXID-RXN] subset: gosubset_prok xref: EC:1.10.3.- is_a: GO:0015002 ! heme-copper terminal oxidase activity is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0008828 name: dATP pyrophosphohydrolase activity namespace: molecular_function def: "Catalysis of the reaction: deoxy-ATP + H2O = dAMP + diphosphate." [MetaCyc:RXN0-384] subset: gosubset_prok xref: EC:3.6.1.- xref: MetaCyc:RXN0-384 is_a: GO:0047429 ! nucleoside-triphosphate diphosphatase activity [Term] id: GO:0008829 name: dCTP deaminase activity namespace: molecular_function def: "Catalysis of the reaction: dCTP + H2O = dUTP + NH3." [EC:3.5.4.13] subset: gosubset_prok synonym: "5-methyl-dCTP deaminase activity" EXACT [EC:3.5.4.13] synonym: "dCTP aminohydrolase activity" EXACT [EC:3.5.4.13] synonym: "deoxycytidine triphosphate deaminase activity" EXACT [EC:3.5.4.13] xref: EC:3.5.4.13 xref: MetaCyc:DCTP-DEAM-RXN xref: Reactome:26405 "dCTP deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008830 name: dTDP-4-dehydrorhamnose 3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-4-dehydro-6-deoxy-D-glucose = dTDP-4-dehydro-6-deoxy-L-mannose." [EC:5.1.3.13] subset: gosubset_prok synonym: "dTDP-4-dehydro-6-deoxy-D-glucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-4-keto-6-deoxyglucose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "dTDP-L-rhamnose synthetase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-keto-L-rhamnose-3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "TDP-4-ketorhamnose 3,5-epimerase activity" EXACT [EC:5.1.3.13] synonym: "thymidine diphospho-4-ketorhamnose 3,5-epimerase activity" RELATED [EC:5.1.3.13] xref: EC:5.1.3.13 xref: MetaCyc:DTDPDEHYDRHAMEPIM-RXN is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0008831 name: dTDP-4-dehydrorhamnose reductase activity namespace: molecular_function def: "Catalysis of the reaction: dTDP-6-deoxy-L-mannose + NADP+ = dTDP-4-dehydro-6-deoxy-L-mannose + NADPH + H+." [EC:1.1.1.133] subset: gosubset_prok synonym: "dTDP-4-keto-L-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose dehydrogenase activity" EXACT [EC:1.1.1.133] synonym: "dTDP-6-deoxy-L-mannose:NADP+ 4-oxidoreductase activity" EXACT [EC:1.1.1.133] synonym: "reductase, thymidine diphospho-4-ketorhamnose" EXACT [EC:1.1.1.133] synonym: "TDP-4-keto-rhamnose reductase activity" EXACT [EC:1.1.1.133] synonym: "thymidine diphospho-4-ketorhamnose reductase activity" EXACT [EC:1.1.1.133] xref: EC:1.1.1.133 xref: MetaCyc:DTDPDEHYRHAMREDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008832 name: dGTPase activity namespace: molecular_function def: "Catalysis of the reaction: dGTP + H2O = deoxyguanosine + triphosphate." [EC:3.1.5.1] subset: gosubset_prok synonym: "deoxy-GTPase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine 5-triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphatase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosine triphosphate triphosphohydrolase activity" EXACT [EC:3.1.5.1] synonym: "deoxyguanosinetriphosphate triphosphohydrolase activity" EXACT [] synonym: "dGTP triphosphohydrolase activity" EXACT [EC:3.1.5.1] xref: EC:3.1.5.1 xref: MetaCyc:DGTPTRIPHYDRO-RXN is_a: GO:0016793 ! triphosphoric monoester hydrolase activity [Term] id: GO:0008833 name: deoxyribonuclease IV (phage-T4-induced) activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 5'-phosphooligonucleotide end-products." [EC:3.1.21.2] subset: gosubset_prok synonym: "deoxriboendonuclease activity" EXACT [EC:3.1.21.2] synonym: "deoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "DNA-adenine-transferase activity" EXACT [EC:3.1.21.2] synonym: "E. coli endonuclease IV" RELATED [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T(4)-induced) activity" EXACT [EC:3.1.21.2] synonym: "endodeoxyribonuclease IV (phage T4-induced) activity" EXACT [EC:3.1.21.2] synonym: "endonuclease II" RELATED [EC:3.1.21.2] synonym: "endonuclease IV activity" RELATED [EC:3.1.21.2] synonym: "Escherichia coli endonuclease II" RELATED [EC:3.1.21.2] synonym: "redoxyendonuclease activity" EXACT [EC:3.1.21.2] xref: EC:3.1.21.2 xref: MetaCyc:3.1.21.2-RXN is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008834 name: di-trans,poly-cis-decaprenylcistransferase activity namespace: molecular_function def: "Catalysis of the reaction: di-trans-poly-cis-decaprenyl diphosphate + isopentenyl diphosphate = diphosphate + di-trans-poly-cis-undecaprenyl diphosphate." [EC:2.5.1.31] subset: gosubset_prok synonym: "bactoprenyl-diphosphate synthase activity" RELATED [EC:2.5.1.31] synonym: "di-trans,poly-cis-decaprenyl-diphosphate:isopentenyl-diphosphate undecaprenylcistransferase activity" EXACT [EC:2.5.1.31] synonym: "di-trans,poly-cis-undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl diphosphate synthase activity" EXACT [] synonym: "undecaprenyl diphosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl pyrophosphate synthetase activity" EXACT [EC:2.5.1.31] synonym: "undecaprenyl-diphosphate synthase activity" EXACT [EC:2.5.1.31] synonym: "UPP synthetase activity" EXACT [EC:2.5.1.31] xref: EC:2.5.1.31 xref: MetaCyc:RXN-8999 is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0008835 name: diaminohydroxyphosphoribosylaminopyrimidine deaminase activity namespace: molecular_function alt_id: GO:0008485 def: "Catalysis of the reaction: 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine + H2O = 5-amino-6-(5-phosphoribosylamino)uracil + NH3." [EC:3.5.4.26] subset: gosubset_prok synonym: "2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate deaminase activity" EXACT [] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] synonym: "2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)pyrimidine 2-aminohydrolase activity" EXACT [EC:3.5.4.26] xref: EC:3.5.4.26 xref: MetaCyc:RIBOFLAVINSYNDEAM-RXN is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008836 name: diaminopimelate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: meso-2,6-diaminoheptanedioate = L-lysine + CO2." [EC:4.1.1.20] subset: gosubset_prok synonym: "DAP decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "DAP-decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "diaminopimelic acid decarboxylase activity" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase (L-lysine-forming)" EXACT [EC:4.1.1.20] synonym: "meso-2,6-diaminoheptanedioate carboxy-lyase activity" EXACT [EC:4.1.1.20] synonym: "meso-diaminopimelate decarboxylase activity" EXACT [EC:4.1.1.20] xref: EC:4.1.1.20 xref: MetaCyc:DIAMINOPIMDECARB-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008837 name: diaminopimelate epimerase activity namespace: molecular_function def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate = meso-diaminoheptanedioate." [EC:5.1.1.7] subset: gosubset_prok synonym: "LL-2,6-diaminoheptanedioate 2-epimerase activity" EXACT [EC:5.1.1.7] xref: EC:5.1.1.7 xref: MetaCyc:DIAMINOPIMEPIM-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008838 name: diaminopropionate ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3-diaminopropionate + H2O = pyruvate + 2 NH3." [EC:4.3.1.15] subset: gosubset_prok synonym: "2,3-diaminopropionate ammonia-lyase (adding H2O; pyruvate-forming)" EXACT [EC:4.3.1.15] synonym: "2,3-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "alpha,beta-diaminopropionate ammonia-lyase activity" EXACT [EC:4.3.1.15] synonym: "diaminopropionatase activity" EXACT [EC:4.3.1.15] xref: EC:4.3.1.15 xref: MetaCyc:4.3.1.15-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008839 name: dihydrodipicolinate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2,3,4,5-tetrahydrodipicolinate + NADP+ = 2,3-dihydrodipicolinate + NADPH + H+." [EC:1.3.1.26] subset: gosubset_prok synonym: "2,3,4,5-tetrahydrodipicolinate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.3.1.26] synonym: "dihydrodipicolinic acid reductase activity" EXACT [EC:1.3.1.26] xref: EC:1.3.1.26 xref: MetaCyc:DIHYDROPICRED-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008840 name: dihydrodipicolinate synthase activity namespace: molecular_function def: "Catalysis of the reaction: L-aspartate-4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O." [EC:4.2.1.52] subset: gosubset_prok synonym: "DHDPS activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "dihydrodipicolinic acid synthase activity" EXACT [EC:4.2.1.52] synonym: "dihydropicolinate synthetase activity" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase (adding pyruvate and cyclizing)" EXACT [EC:4.2.1.52] synonym: "L-aspartate-4-semialdehyde hydro-lyase [adding pyruvate and cyclizing; (S)-2,3-dihydropyridine-2,6-dicarboxylate-forming]" RELATED [EC:4.2.1.52] xref: EC:4.2.1.52 xref: MetaCyc:DIHYDRODIPICSYN-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008841 name: dihydrofolate synthase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate." [EC:6.3.2.12] subset: gosubset_prok synonym: "7,8-dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP) activity" EXACT [EC:6.3.2.12] synonym: "7,8-dihydropteroate:L-glutamate ligase (ADP-forming)" EXACT [EC:6.3.2.12] synonym: "DHFS activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydrofolate synthetase-folylpolyglutamate synthetase activity" EXACT [EC:6.3.2.12] synonym: "dihydropteroate:L-glutamate ligase (ADP-forming) activity" EXACT [EC:6.3.2.12] synonym: "FHFS activity" EXACT [EC:6.3.2.12] synonym: "FHFS/FPGS activity" EXACT [EC:6.3.2.12] synonym: "folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity" EXACT [EC:6.3.2.12] synonym: "H(2)-folate synthetase activity" EXACT [EC:6.3.2.12] synonym: "H2-folate synthetase activity" EXACT [EC:6.3.2.12] xref: EC:6.3.2.12 xref: MetaCyc:DIHYDROFOLATESYNTH-RXN is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0008842 name: diphosphate-purine nucleoside kinase activity namespace: molecular_function def: "Catalysis of the reaction: diphosphate + a purine nucleoside = monophosphate + a purine mononucleotide." [EC:2.7.1.143] synonym: "diphosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "diphosphate:purine nucleoside phosphotransferase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-dependent nucleoside kinase activity" EXACT [EC:2.7.1.143] synonym: "pyrophosphate-purine nucleoside kinase activity" EXACT [EC:2.7.1.143] xref: EC:2.7.1.143 xref: MetaCyc:2.7.1.143-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019206 ! nucleoside kinase activity [Term] id: GO:0008843 name: endochitinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of nonterminal 1,4-beta-linkages of N-acetyl-D-glucosamine polymers of chitin and chitodextrins." [EC:3.2.1.14] is_a: GO:0004568 ! chitinase activity [Term] id: GO:0008845 name: endonuclease VIII activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [PMID:12713806] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0000703 consider: GO:0003684 consider: GO:0003906 consider: GO:0004519 consider: GO:0008081 consider: GO:0019104 [Term] id: GO:0008846 name: endopeptidase La activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of large proteins such as globin, casein and denatured serum albumin, in presence of ATP." [EC:3.4.21.53] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "ATP-dependent lon proteinase" NARROW [EC:3.4.21.53] synonym: "ATP-dependent protease La activity" EXACT [EC:3.4.21.53] synonym: "ATP-dependent serine proteinase activity" RELATED [EC:3.4.21.53] synonym: "Escherichia coli proteinase La" RELATED [EC:3.4.21.53] synonym: "Escherichia coli serine proteinase La" RELATED [EC:3.4.21.53] synonym: "gene lon protease activity" EXACT [EC:3.4.21.53] synonym: "gene lon proteins" RELATED [EC:3.4.21.53] synonym: "lon proteinase" NARROW [EC:3.4.21.53] synonym: "PIM1 protease activity" EXACT [EC:3.4.21.53] synonym: "PIM1 proteinase activity" EXACT [EC:3.4.21.53] synonym: "protease La" RELATED [EC:3.4.21.53] synonym: "proteinase La" RELATED [EC:3.4.21.53] synonym: "serine protease La" RELATED [EC:3.4.21.53] xref: EC:3.4.21.53 xref: MetaCyc:3.4.21.53-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008847 name: Enterobacter ribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage to 3'-phosphomononucleotides and 3'-phosphooligonucleotides with 2',3'-cyclic phosphate intermediates." [EC:3.1.27.6] subset: gosubset_prok synonym: "enterobacter ribonuclease activity" EXACT [EC:3.1.27.6] synonym: "Enterobacter RNase activity" EXACT [] xref: EC:3.1.27.6 xref: MetaCyc:3.1.27.6-RXN is_a: GO:0016892 ! endoribonuclease activity, producing 3'-phosphomonoesters [Term] id: GO:0008848 name: enterobactin synthetase namespace: molecular_function alt_id: GO:0008850 def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a process rather than a function. synonym: "enterochelin synthetase activity" EXACT [] synonym: "nonribosomal peptide synthetase" RELATED [] is_obsolete: true replaced_by: GO:0009239 [Term] id: GO:0008849 name: enterochelin esterase activity namespace: molecular_function def: "Catalysis of the hydrolysis of the enterochelin moiety of ferric-enterochelin to yield ultimately three molecules of N-2,3-dihydroxybenzoylserine." [PMID:4565531] synonym: "enterobactin esterase activity" EXACT [] is_a: GO:0016788 ! hydrolase activity, acting on ester bonds [Term] id: GO:0008851 name: ethanolamine ammonia-lyase activity namespace: molecular_function def: "Catalysis of the reaction: ethanolamine = acetaldehyde + NH3." [EC:4.3.1.7] subset: gosubset_prok synonym: "ethanolamine ammonia-lyase (acetaldehyde-forming) activity" EXACT [EC:4.3.1.7] synonym: "ethanolamine deaminase activity" EXACT [EC:4.3.1.7] xref: EC:4.3.1.7 xref: MetaCyc:ETHAMLY-RXN is_a: GO:0016841 ! ammonia-lyase activity [Term] id: GO:0008852 name: exodeoxyribonuclease I activity namespace: molecular_function def: "Catalysis of the degradation of single-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.1] subset: gosubset_prok synonym: "E. coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "E. coli exonuclease I activity" NARROW [EC:3.1.11.1] synonym: "Escherichia coli exonuclease I" RELATED [EC:3.1.11.1] synonym: "exonuclease I activity" RELATED [EC:3.1.11.1] xref: EC:3.1.11.1 xref: MetaCyc:3.1.11.1-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008853 name: exodeoxyribonuclease III activity namespace: molecular_function def: "Catalysis of the degradation of double-stranded DNA. It acts progressively in a 3' to 5' direction, releasing 5'-phosphomononucleotides." [EC:3.1.11.2] subset: gosubset_prok synonym: "E. coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "E. coli exonuclease III activity" NARROW [EC:3.1.11.2] synonym: "endoribonuclease III" RELATED [EC:3.1.11.2] synonym: "Escherichia coli exonuclease III" RELATED [EC:3.1.11.2] synonym: "exonuclease III activity" EXACT [EC:3.1.11.2] xref: EC:3.1.11.2 xref: MetaCyc:3.1.11.2-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008854 name: exodeoxyribonuclease V activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides." [EC:3.1.11.5] subset: gosubset_prok synonym: "E. coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "E. coli exonuclease V activity" NARROW [EC:3.1.11.5] synonym: "Escherichia coli exonuclease V" RELATED [EC:3.1.11.5] synonym: "exonuclease V activity" EXACT [EC:3.1.11.5] synonym: "gene recBC DNase activity" EXACT [EC:3.1.11.5] synonym: "gene recBC endoenzyme" RELATED [EC:3.1.11.5] synonym: "gene recBCD enzymes" RELATED [EC:3.1.11.5] synonym: "RecBC deoxyribonuclease activity" EXACT [EC:3.1.11.5] xref: EC:3.1.11.5 xref: MetaCyc:3.1.11.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008855 name: exodeoxyribonuclease VII activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield 5'-phosphomononucleotides." [EC:3.1.11.6] subset: gosubset_prok synonym: "E. coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "E. coli exonuclease VII activity" NARROW [EC:3.1.11.6] synonym: "endodeoxyribonuclease VII" RELATED [EC:3.1.11.6] synonym: "Escherichia coli exonuclease VII" RELATED [EC:3.1.11.6] synonym: "exonuclease VII activity" EXACT [EC:3.1.11.6] xref: EC:3.1.11.6 xref: MetaCyc:3.1.11.6-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008856 name: exodeoxyribonuclease X activity namespace: molecular_function def: "Catalysis of the reaction: Endonucleolytic cleavage of supercoiled plasma DNA to linear DNA duplexes." [EC:3.1.22.5] synonym: "deoxyribonuclease X activity" EXACT [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease activity" RELATED [EC:3.1.22.5] synonym: "Escherichia coli endodeoxyribonuclease X activity" NARROW [EC:3.1.22.5] xref: EC:3.1.11.- xref: MetaCyc:3.1.22.5-RXN is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008857 name: exonuclease IX activity namespace: molecular_function subset: gosubset_prok is_a: GO:0004527 ! exonuclease activity [Term] id: GO:0008858 name: exonuclease VIII activity namespace: molecular_function xref: EC:3.1.11.- is_a: GO:0016895 ! exodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008859 name: exoribonuclease II activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction." [EC:3.1.13.1, ISBN:0198547684] subset: gosubset_prok synonym: "5'-exoribonuclease activity" EXACT [EC:3.1.13.1] synonym: "BN ribonuclease activity" EXACT [EC:3.1.13.1] synonym: "Escherichia coli exo-RNase II" RELATED [EC:3.1.13.1] synonym: "ribonuclease II activity" EXACT [EC:3.1.13.1] synonym: "ribonuclease Q" RELATED [EC:3.1.13.1] synonym: "RNase II" RELATED [EC:3.1.13.1] synonym: "RNase II activity" EXACT [] xref: EC:3.1.13.1 xref: MetaCyc:3.1.13.1-RXN is_a: GO:0008408 ! 3'-5' exonuclease activity is_a: GO:0016896 ! exoribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0008860 name: ferredoxin-NAD+ reductase activity namespace: molecular_function def: "Catalysis of the reaction: reduced ferredoxin + NAD+ = oxidized ferredoxin + NADH + H+." [EC:1.18.1.3] subset: gosubset_prok synonym: "ferredoxin-linked NAD reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin-NAD reductase activity" EXACT [] synonym: "ferredoxin-nicotinamide adenine dinucleotide reductase activity" EXACT [EC:1.18.1.3] synonym: "ferredoxin:NAD+ oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NAD-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH flavodoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxin reductase activity" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinNAP reductase (component of naphthalene dioxygenase multicomponent enzyme system)" EXACT [EC:1.18.1.3] synonym: "NADH-ferredoxinTOL reductase (component of toluene dioxygenase)" EXACT [EC:1.18.1.3] synonym: "NADH2-ferredoxin oxidoreductase activity" EXACT [EC:1.18.1.3] synonym: "reductase, reduced nicotinamide adenine dinucleotide-ferredoxin" EXACT [EC:1.18.1.3] xref: EC:1.18.1.3 xref: MetaCyc:FERREDOXIN--NAD+-REDUCTASE-RXN is_a: GO:0008937 ! ferredoxin reductase activity [Term] id: GO:0008861 name: formate C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate." [EC:2.3.1.54] subset: gosubset_prok synonym: "acetyl-CoA:formate C-acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "formate acetyltransferase activity" EXACT [EC:2.3.1.54] synonym: "pyruvate formate-lyase activity" EXACT [EC:2.3.1.54] synonym: "pyruvic formate-lyase activity" EXACT [EC:2.3.1.54] xref: EC:2.3.1.54 xref: MetaCyc:PYRUVFORMLY-RXN is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008863 name: formate dehydrogenase activity namespace: molecular_function alt_id: GO:0018476 def: "Catalysis of the reaction: formate + NAD+ = CO2 + NADH + H+." [EC:1.2.1.2] subset: gosubset_prok synonym: "FDH I" RELATED [EC:1.2.1.2] synonym: "FDH II" RELATED [EC:1.2.1.2] synonym: "formate benzyl-viologen oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate dehydrogenase (NAD)" EXACT [EC:1.2.1.2] synonym: "formate hydrogenlyase" EXACT [EC:1.2.1.2] synonym: "formate-NAD oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formate:NAD+ oxidoreductase" EXACT [EC:1.2.1.2] synonym: "formic acid dehydrogenase" EXACT [EC:1.2.1.2] synonym: "formic hydrogen-lyase" EXACT [EC:1.2.1.2] synonym: "N-FDH" RELATED [EC:1.2.1.2] synonym: "NAD-dependent formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-formate dehydrogenase" EXACT [EC:1.2.1.2] synonym: "NAD-linked formate dehydrogenase" EXACT [EC:1.2.1.2] xref: EC:1.2.1.2 xref: MetaCyc:FORMATEDEHYDROG-RXN xref: UM-BBD_enzymeID:e0080 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008864 name: formyltetrahydrofolate deformylase activity namespace: molecular_function def: "Catalysis of the reaction: 10-formyltetrahydrofolate + H2O = formate + tetrahydrofolate." [EC:3.5.1.10] subset: gosubset_prok synonym: "10-formyltetrahydrofolate amidohydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyl-FH(4) hydrolase activity" EXACT [EC:3.5.1.10] synonym: "formyltetrahydrofolate hydrolase activity" EXACT [EC:3.5.1.10] xref: EC:3.5.1.10 xref: MetaCyc:FORMYLTHFDEFORMYL-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008865 name: fructokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-fructose = ADP + D-fructose 6-phosphate." [EC:2.7.1.4] subset: gosubset_prok synonym: "ATP:D-fructose 6-phosphotransferase activity" EXACT [EC:2.7.1.4] synonym: "D-fructokinase activity" EXACT [EC:2.7.1.4] synonym: "D-fructose(D-mannose)kinase activity" EXACT [EC:2.7.1.4] synonym: "fructokinase (phosphorylating)" EXACT [EC:2.7.1.4] xref: EC:2.7.1.4 xref: MetaCyc:FRUCTOKINASE-RXN is_a: GO:0004396 ! hexokinase activity [Term] id: GO:0008866 name: fructuronate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate + NAD+ = D-fructuronate + NADH + H+." [EC:1.1.1.57] subset: gosubset_prok synonym: "D-mannonate dehydrogenase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "D-mannonate:NAD+ 5-oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonate oxidoreductase activity" EXACT [EC:1.1.1.57] synonym: "mannonic dehydrogenase activity" EXACT [EC:1.1.1.57] xref: EC:1.1.1.57 xref: MetaCyc:MANNONOXIDOREDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008867 name: galactarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.42] subset: gosubset_prok synonym: "D-galactarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.42] synonym: "D-galactarate hydro-lyase activity" EXACT [EC:4.2.1.42] xref: EC:4.2.1.42 xref: MetaCyc:GALACTARDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008868 name: galactitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: galactitol-1-phosphate + NAD+ = L-tagatose 6-phosphate + NADH + H+." [EC:1.1.1.251] subset: gosubset_prok synonym: "galactitol-1-phosphate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.251] xref: EC:1.1.1.251 xref: MetaCyc:1.1.1.251-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008869 name: galactonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-galactonate = 2-dehydro-3-deoxy-D-galactonate + H2O." [EC:4.2.1.6] subset: gosubset_prok synonym: "D-galactonate dehydrase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate dehydratase activity" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase (2-dehydro-3-deoxy-D-galactonate-forming)" EXACT [EC:4.2.1.6] synonym: "D-galactonate hydro-lyase activity" EXACT [EC:4.2.1.6] xref: EC:4.2.1.6 xref: MetaCyc:GALACTONDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008870 name: galactoside O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + a beta-D-galactoside = CoA + a 6-acetyl-beta-D-galactoside." [EC:2.3.1.18] subset: gosubset_prok synonym: "acetyl-CoA:beta-D-galactoside 6-acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "galactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside acetyltransferase activity" EXACT [EC:2.3.1.18] synonym: "thiogalactoside transacetylase activity" EXACT [EC:2.3.1.18] xref: EC:2.3.1.18 xref: MetaCyc:GALACTOACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008871 name: aminoglycoside 2''-nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: nucleoside triphosphate + aminoglycoside = diphosphate + 2''-nucleotidylaminoglycoside." [EC:2.7.7.46, GOC:cb] subset: gosubset_prok synonym: "2''-aminoglycoside nucleotidyltransferase activity" EXACT [EC:2.7.7.46] synonym: "gentamicin 2''- adenylyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "gentamycin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] synonym: "NTP:gentamicin 2''-nucleotidyltransferase activity" NARROW [EC:2.7.7.46] xref: EC:2.7.7.46 xref: MetaCyc:2.7.7.46-RXN is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0008872 name: glucarate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O." [EC:4.2.1.40] subset: gosubset_prok synonym: "D-glucarate dehydratase activity" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase (5-dehydro-4-deoxy-D-glucarate-forming)" EXACT [EC:4.2.1.40] synonym: "D-glucarate hydro-lyase activity" EXACT [EC:4.2.1.40] xref: EC:4.2.1.40 xref: MetaCyc:GLUCARDEHYDRA-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008873 name: gluconate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 2-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215] subset: gosubset_prok synonym: "2-keto-D-gluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "2-ketogluconate reductase activity" EXACT [EC:1.1.1.215] synonym: "D-gluconate:NADP+ oxidoreductase activity" EXACT [EC:1.1.1.215] xref: EC:1.1.1.215 xref: MetaCyc:1.1.1.215-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008874 name: gluconate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = 5-dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.69] subset: gosubset_prok synonym: "5-keto-D-gluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-keto-D-gluconate reductase" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate 5-reductase activity" EXACT [EC:1.1.1.69] synonym: "5-ketogluconate reductase activity" EXACT [EC:1.1.1.69] synonym: "D-gluconate:NAD(P)+ 5-oxidoreductase" EXACT [EC:1.1.1.69] xref: EC:1.1.1.69 xref: MetaCyc:GLUCONATE-5-DEHYDROGENASE-RXN is_a: GO:0008875 ! gluconate dehydrogenase activity [Term] id: GO:0008875 name: gluconate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-gluconate + NADP+ = dehydro-D-gluconate + NADPH + H+." [EC:1.1.1.215, EC:1.1.1.69] subset: gosubset_prok xref: EC:1.1.1.- is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008876 name: quinoprotein glucose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose + ubiquinone = D-glucono-1,5-lactone + ubiquinol." [EC:1.1.5.2] comment: Note that this was EC:1.1.99.17. subset: gosubset_prok synonym: "D-glucose:(pyrroloquinoline-quinone) 1-oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "D-glucose:ubiquinone oxidoreductase activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (PQQ-dependent) activity" EXACT [EC:1.1.5.2] synonym: "glucose dehydrogenase (pyrroloquinoline-quinone) activity" EXACT [] synonym: "quinoprotein D-glucose dehydrogenase activity" EXACT [EC:1.1.5.2] xref: EC:1.1.5.2 xref: MetaCyc:GLUCDEHYDROG-RXN is_a: GO:0004344 ! glucose dehydrogenase activity is_a: GO:0016901 ! oxidoreductase activity, acting on the CH-OH group of donors, quinone or similar compound as acceptor [Term] id: GO:0008877 name: glucose-1-phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucose 1-phosphate + H2O = D-glucose + phosphate." [EC:3.1.3.10] subset: gosubset_prok synonym: "alpha-D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] synonym: "D-glucose-1-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.10] xref: EC:3.1.3.10 xref: MetaCyc:GLUCOSE-1-PHOSPHAT-RXN is_a: GO:0019203 ! carbohydrate phosphatase activity [Term] id: GO:0008878 name: glucose-1-phosphate adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + alpha-D-glucose 1-phosphate = diphosphate + ADP-glucose." [EC:2.7.7.27] subset: gosubset_prok synonym: "adenosine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "adenosine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADGase activity" EXACT [] synonym: "ADP glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose diphosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthase activity" EXACT [EC:2.7.7.27] synonym: "ADP-glucose synthetase activity" EXACT [EC:2.7.7.27] synonym: "ADP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ADPG pyrophosphorylase activity" EXACT [] synonym: "ATP:alpha-D-glucose-1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] synonym: "ATP:alpha-glucose-1-phosphate adenylyl transferase activity" EXACT [] synonym: "glucose 1-phosphate adenylyltransferase activity" EXACT [EC:2.7.7.27] xref: EC:2.7.7.27 xref: MetaCyc:GLUC1PADENYLTRANS-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008879 name: glucose-1-phosphate thymidylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: dTTP + alpha-D-glucose 1-phosphate = diphosphate + dTDP-glucose." [EC:2.7.7.24] subset: gosubset_prok synonym: "dTDP-glucose diphosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "dTDP-glucose synthase activity" EXACT [EC:2.7.7.24] synonym: "dTTP:alpha-D-glucose-1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "glucose 1-phosphate thymidylyltransferase activity" EXACT [EC:2.7.7.24] synonym: "TDP-glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphate glucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] synonym: "thymidine diphosphoglucose pyrophosphorylase activity" EXACT [EC:2.7.7.24] xref: EC:2.7.7.24 xref: MetaCyc:DTDPGLUCOSEPP-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0008880 name: glucuronate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucuronate = D-fructuronate." [EC:5.3.1.12] subset: gosubset_prok synonym: "D-glucuronate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "D-glucuronate ketol-isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronate isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic acid isomerase activity" EXACT [EC:5.3.1.12] synonym: "uronic isomerase activity" EXACT [EC:5.3.1.12] xref: EC:5.3.1.12 xref: MetaCyc:GLUCUROISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008881 name: glutamate racemase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate = D-glutamate." [EC:5.1.1.3] subset: gosubset_prok xref: EC:5.1.1.3 xref: MetaCyc:GLUTRACE-RXN is_a: GO:0047661 ! amino-acid racemase activity [Term] id: GO:0008882 name: [glutamate-ammonia-ligase] adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (L-glutamate:ammonia ligase (ADP-forming)) = diphosphate + adenylyl-(L-glutamate:ammonia ligase (ADP-forming))." [EC:2.7.7.42] subset: gosubset_prok synonym: "adenosine triphosphate:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:[glutamate-ammonia-ligase] adenylyltransferase activity" EXACT [] synonym: "ATP:glutamine synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "ATP:L-glutamate:ammonia ligase (ADP-forming) adenylyltransferase activity" EXACT [EC:2.7.7.42] synonym: "glutamate-ammonia-ligase adenylyltransferase activity" EXACT [] synonym: "glutamine-synthetase adenylyltransferase activity" EXACT [EC:2.7.7.42] xref: EC:2.7.7.42 xref: MetaCyc:GSADENYLATION-RXN is_a: GO:0070566 ! adenylyltransferase activity [Term] id: GO:0008883 name: glutamyl-tRNA reductase activity namespace: molecular_function def: "Catalysis of the reaction: L-glutamate 1-semialdehyde + NADP+ + tRNA(Glu) = L-glutamyl-tRNA(Glu) + NADPH + H+." [EC:1.2.1.70, MetaCyc:GLUTRNAREDUCT-RXN] subset: gosubset_prok synonym: "L-glutamate-semialdehyde: NADP+ oxidoreductase (L-glutamyl-tRNAGlu-forming)" EXACT [EC:1.2.1.70] xref: EC:1.2.1.70 xref: MetaCyc:GLUTRNAREDUCT-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008884 name: glutathionylspermidine amidase activity namespace: molecular_function def: "Catalysis of the reaction: N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + H2O = gamma-L-glutamyl-L-cysteinyl-glycine + spermidine." [EC:3.5.1.78] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine amidase activity" EXACT [EC:3.5.1.78] synonym: "glutathionylspermidine amidohydrolase (spermidine-forming) activity" EXACT [EC:3.5.1.78] synonym: "GSP amidase activity" EXACT [EC:3.5.1.78] xref: EC:3.5.1.78 xref: MetaCyc:GSPAMID-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008885 name: glutathionylspermidine synthase activity namespace: molecular_function def: "Catalysis of the reaction: gamma-L-glutamyl-L-cysteinyl-glycine + spermidine + ATP = N1-(gamma-L-glutamyl-L-cysteinyl-glycyl)-spermidine + ADP + phosphate." [EC:6.3.1.8] subset: gosubset_prok synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) [spermidine is numbered so that atom N-1 is in the amino group of the aminopropyl part of the molecule]" RELATED [EC:6.3.1.8] synonym: "gamma-L-glutamyl-L-cysteinyl-glycine:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathione:spermidine ligase (ADP-forming) activity" EXACT [EC:6.3.1.8] synonym: "glutathionylspermidine synthetase activity" EXACT [EC:6.3.1.8] synonym: "GSP synthetase activity" EXACT [EC:6.3.1.8] xref: EC:6.3.1.8 xref: MetaCyc:GSPSYN-RXN is_a: GO:0016880 ! acid-ammonia (or amide) ligase activity [Term] id: GO:0008886 name: glyceraldehyde-3-phosphate dehydrogenase (NADP+) activity namespace: molecular_function def: "Catalysis of the reaction: D-glyceraldehyde 3-phosphate + NADP+ + H2O = 3-phospho-D-glycerate + NADPH + H+." [EC:1.2.1.9] subset: gosubset_prok synonym: "D-glyceraldehyde-3-phosphate:NADP+ oxidoreductase activity" EXACT [] synonym: "dehydrogenase, glyceraldehyde phosphate (nicotinamide adenine dinucleotide phosphate)" BROAD [] synonym: "glyceraldehyde 3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde phosphate dehydrogenase (NADP)" BROAD [] synonym: "glyceraldehyde-3-phosphate dehydrogenase (NADP)" EXACT [] synonym: "glyceraldehyde-3-phosphate:NADP reductase activity" EXACT [] synonym: "NADP-glyceraldehyde phosphate dehydrogenase" BROAD [] synonym: "NADP-glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "nonphosphorylating glyceraldehyde-3-phosphate dehydrogenase activity" EXACT [] synonym: "triosephosphate dehydrogenase activity" BROAD [EC:1.2.1.9] xref: EC:1.2.1.9 xref: MetaCyc:1.2.1.9-RXN is_a: GO:0008943 ! glyceraldehyde-3-phosphate dehydrogenase activity [Term] id: GO:0008887 name: glycerate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (R)-glycerate = ADP + 3-phospho-(R)-glycerate." [EC:2.7.1.31] subset: gosubset_prok synonym: "ATP:(R)-glycerate 3-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "ATP:D-glycerate 2-phosphotransferase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate 3-kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glycerate kinase activity" EXACT [EC:2.7.1.31] synonym: "D-glyceric acid kinase activity" EXACT [EC:2.7.1.31] synonym: "GK" RELATED [EC:2.7.1.31] synonym: "glycerate kinase (phosphorylating)" EXACT [EC:2.7.1.31] synonym: "glycerate-3-kinase activity" EXACT [EC:2.7.1.31] xref: EC:2.7.1.31 xref: MetaCyc:GLY3KIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008888 name: glycerol dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glycerol + NAD+ = glycerone + NADH + H+." [EC:1.1.1.6] subset: gosubset_prok synonym: "NAD-linked glycerol dehydrogenase activity" EXACT [EC:1.1.1.6] xref: EC:1.1.1.6 xref: MetaCyc:GLYCDEH-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008889 name: glycerophosphodiester phosphodiesterase activity namespace: molecular_function def: "Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate." [EC:3.1.4.46] subset: gosubset_prok synonym: "gene hpd protein" RELATED [EC:3.1.4.46] synonym: "glycerophosphodiester glycerophosphohydrolase activity" EXACT [EC:3.1.4.46] synonym: "glycerophosphoryl diester phosphodiesterase activity" EXACT [EC:3.1.4.46] synonym: "IgD-binding protein D" RELATED [EC:3.1.4.46] xref: EC:3.1.4.46 xref: MetaCyc:GLYCPDIESTER-RXN is_a: GO:0008081 ! phosphoric diester hydrolase activity [Term] id: GO:0008890 name: glycine C-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + glycine = CoA + 2-amino-3-oxobutanoate." [EC:2.3.1.29] subset: gosubset_prok synonym: "2-amino-3-ketobutyrate CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate coenzyme A ligase activity" EXACT [EC:2.3.1.29] synonym: "2-amino-3-ketobutyrate-CoA ligase activity" EXACT [EC:2.3.1.29] synonym: "acetyl-CoA:glycine C-acetyltransferase activity" EXACT [EC:2.3.1.29] synonym: "aminoacetone synthase activity" EXACT [EC:2.3.1.29] synonym: "glycine acetyltransferase activity" EXACT [EC:2.3.1.29] xref: EC:2.3.1.29 xref: MetaCyc:AKBLIG-RXN is_a: GO:0016453 ! C-acetyltransferase activity [Term] id: GO:0008891 name: glycolate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: glycolate + O2 = glyoxylate + H2O2." [EC:1.1.3.15] subset: gosubset_prok xref: MetaCyc:RXN-969 xref: Reactome:26481 "glycolate oxidase activity" is_a: GO:0003973 ! (S)-2-hydroxy-acid oxidase activity [Term] id: GO:0008892 name: guanine deaminase activity namespace: molecular_function def: "Catalysis of the reaction: guanine + H2O = xanthine + NH3." [EC:3.5.4.3] subset: gosubset_prok synonym: "GAH activity" EXACT [EC:3.5.4.3] synonym: "guanase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminase activity" EXACT [EC:3.5.4.3] synonym: "guanine aminohydrolase activity" EXACT [EC:3.5.4.3] xref: EC:3.5.4.3 xref: MetaCyc:GUANINE-DEAMINASE-RXN xref: Reactome:26482 "guanine deaminase activity" is_a: GO:0016814 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amidines is_a: GO:0019239 ! deaminase activity [Term] id: GO:0008893 name: guanosine-3',5'-bis(diphosphate) 3'-diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 3',5'-bis(diphosphate) + H2O = guanosine 5'-diphosphate + diphosphate." [EC:3.1.7.2] subset: gosubset_prok synonym: "(ppGpp)ase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-diphosphohydrolase activity" EXACT [] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphatase activity" EXACT [EC:3.1.7.2] synonym: "guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase activity" EXACT [] synonym: "penta-phosphate guanosine-3'-diphosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "penta-phosphate guanosine-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp phosphohydrolase activity" EXACT [EC:3.1.7.2] synonym: "PpGpp-3'-pyrophosphohydrolase activity" EXACT [EC:3.1.7.2] xref: EC:3.1.7.2 xref: MetaCyc:PPGPPSYN-RXN is_a: GO:0016794 ! diphosphoric monoester hydrolase activity [Term] id: GO:0008894 name: guanosine-5'-triphosphate,3'-diphosphate diphosphatase activity namespace: molecular_function def: "Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate." [EC:3.6.1.40] subset: gosubset_prok synonym: "guanosine 5'-triphosphate 3'-diphosphate 5'-phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine 5'-triphosphate-3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphatase activity" EXACT [EC:3.6.1.40] synonym: "guanosine pentaphosphate phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] synonym: "guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase activity" EXACT [] synonym: "pppGpp 5'-phosphohydrolase activity" EXACT [EC:3.6.1.40] xref: EC:3.6.1.40 xref: MetaCyc:PPPGPPHYDRO-RXN is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0008897 name: holo-[acyl-carrier-protein] synthase activity namespace: molecular_function alt_id: GO:0008958 def: "Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form." [EC:2.7.8.7, PMID:10320345, PMID:11867633, PMID:8939709] subset: gosubset_prok synonym: "4'-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "4'-phosphopantetheinyltransferase activity" EXACT [] synonym: "AcpS" RELATED [EC:2.7.8.7] synonym: "ACPS activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein holoprotein (holo-ACP) synthetase activity" EXACT [EC:2.7.8.7] synonym: "acyl carrier protein synthase activity" RELATED [EC:2.7.8.7] synonym: "acyl carrier protein synthetase activity" RELATED [EC:2.7.8.7] synonym: "alpha-aminoadipate reductase phosphopantetheinyl transferase activity" EXACT [] synonym: "alpha-aminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "alphaaminoadipic semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" EXACT [EC:2.7.8.7] synonym: "CoA-[4'-phosphopantetheine]:apo-acyl-carrier-protein 4'-pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "CoA:apo-acyl-carrier-protein pantetheinephosphotransferase activity" EXACT [EC:2.7.8.7] synonym: "coenzyme A:fatty acid synthetase apoenzyme 4'-phosphopantetheine transferase activity" EXACT [EC:2.7.8.7] synonym: "holo-[acyl-carrier-protein] synthase activity" NARROW [] synonym: "holo-[peptidyl-carrier protein] synthase activity" NARROW [] synonym: "holo-ACP synthase activity" RELATED [EC:2.7.8.7] synonym: "holo-ACP synthetase activity" RELATED [EC:2.7.8.7] synonym: "holo-acyl-carrier-protein synthase activity" EXACT [EC:2.7.8.7] synonym: "holosynthase activity" RELATED [EC:2.7.8.7] synonym: "L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase activity" NARROW [EC:2.7.8.7] synonym: "P-pant transferase activity" EXACT [EC:2.7.8.7] synonym: "phosphopantetheinyltransferase activity" EXACT [] synonym: "PPTase activity" EXACT [EC:2.7.8.7] xref: EC:2.7.8.7 xref: MetaCyc:HOLO-ACP-SYNTH-RXN xref: Reactome:26486 "holo-[acyl-carrier-protein] synthase activity" is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008898 name: homocysteine S-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + L-homocysteine = S-adenosyl-L-homocysteine + L-methionine." [EC:2.1.1.10] subset: gosubset_prok synonym: "adenosylmethionine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "methylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosyl-L-methionine:L-homocysteine S-methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine-homocysteine transmethylase activity" EXACT [EC:2.1.1.10] synonym: "S-adenosylmethionine:homocysteine methyltransferase activity" EXACT [EC:2.1.1.10] synonym: "S-methylmethionine homocysteine transmethylase activity" EXACT [EC:2.1.1.10] xref: EC:2.1.1.10 xref: MetaCyc:HOMOCYSTEINE-S-METHYLTRANSFERASE-RXN is_a: GO:0008172 ! S-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008899 name: homoserine O-succinyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: succinyl-CoA + L-homoserine = CoA + O-succinyl-L-homoserine." [EC:2.3.1.46] subset: gosubset_prok synonym: "homoserine O-transsuccinylase activity" BROAD [EC:2.3.1.46] synonym: "homoserine succinyltransferase activity" EXACT [EC:2.3.1.46] synonym: "succinyl-CoA:L-homoserine O-succinyltransferase activity" EXACT [EC:2.3.1.46] xref: EC:2.3.1.46 xref: MetaCyc:HOMSUCTRAN-RXN is_a: GO:0016750 ! O-succinyltransferase activity [Term] id: GO:0008900 name: hydrogen:potassium-exchanging ATPase activity namespace: molecular_function alt_id: GO:0005390 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + H+(in) + K+(out) = ADP + phosphate + H+(out) + K+(in)." [EC:3.6.3.10] subset: gosubset_prok synonym: "(K+ + H+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "ATP phosphohydrolase (H+/K+-exchanging)" EXACT [EC:3.6.3.10] synonym: "gastric H(+)/K(+) ATPase activity" NARROW [EC:3.6.3.10] synonym: "gastric H+/K+ ATPase" NARROW [EC:3.6.3.10] synonym: "H(+)/K(+)-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H(+)/K(+)-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+-K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-ATPase activity" EXACT [EC:3.6.3.10] synonym: "H+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "h+/K+-exchanging ATPase activity" EXACT [EC:3.6.3.10] synonym: "H,K-ATPase activity" EXACT [EC:3.6.3.10] synonym: "hydrogen/potassium-exchanging ATPase activity" EXACT [] synonym: "hydrogen:potassium exchanging ATPase activity" EXACT [] synonym: "proton pump activity" BROAD [EC:3.6.3.10] xref: EC:3.6.3.10 is_a: GO:0008556 ! potassium-transporting ATPase activity is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity [Term] id: GO:0008901 name: ferredoxin hydrogenase activity namespace: molecular_function alt_id: GO:0016948 alt_id: GO:0016949 alt_id: GO:0016950 alt_id: GO:0016951 def: "Catalysis of the reaction: 2 reduced ferredoxin + 2 H+ = 2 oxidized ferredoxin + H2." [EC:1.12.7.2] comment: Note that this function was formerly EC 1.12.1.1, EC 1.12.7.1, EC 1.98.1.1, EC 1.18.3.1 and EC 1.18.99.1. subset: gosubset_prok synonym: "[Fe] hydrogenase activity" EXACT [] synonym: "[Fe] hydrogenase gamma" RELATED [] synonym: "bidirectional hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) oxidizing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H(2) producing hydrogenase activity" BROAD [EC:1.12.7.2] synonym: "H2 oxidizing hydrogenase" BROAD [] synonym: "H2 producing hydrogenase" BROAD [] synonym: "hydrogen-lyase activity" BROAD [EC:1.12.7.2] synonym: "hydrogen:ferredoxin oxidoreductase activity" EXACT [] synonym: "hydrogenase (ferredoxin) activity" EXACT [EC:1.12.7.2] synonym: "hydrogenase activity" BROAD [] synonym: "hydrogenase I" RELATED [] synonym: "hydrogenase II" RELATED [] synonym: "hydrogenlyase activity" BROAD [EC:1.12.7.2] synonym: "iron hydrogenase activity" NARROW [] synonym: "iron-only hydrogenase activity" NARROW [] synonym: "Ni-Fe hydrogenase activity" NARROW [] synonym: "Ni-Fe-Se hydrogenase activity" NARROW [] synonym: "nickel hydrogenase activity" NARROW [] synonym: "nickel-iron hydrogenase activity" NARROW [] synonym: "nickel-iron-selenium hydrogenase activity" NARROW [] synonym: "uptake hydrogenase activity" BROAD [EC:1.12.7.2] xref: EC:1.12.7.2 xref: MetaCyc:HYDROG-RXN xref: UM-BBD_enzymeID:e0418 is_a: GO:0016699 ! oxidoreductase activity, acting on hydrogen as donor, iron-sulfur protein as acceptor [Term] id: GO:0008902 name: hydroxymethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-hydroxymethylpyrimidine = ADP + 4-amino-2-methyl-5-phosphomethylpyrimidine." [EC:2.7.1.49] subset: gosubset_prok synonym: "ATP:4-amino-5-hydroxymethyl-2-methylpyrimidine 5-phosphotransferase activity" EXACT [EC:2.7.1.49] synonym: "hydroxymethylpyrimidine kinase (phosphorylating)" EXACT [EC:2.7.1.49] xref: EC:2.7.1.49 xref: MetaCyc:OHMETPYRKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008903 name: hydroxypyruvate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: hydroxypyruvate = 2-hydroxy-3-oxopropanoate." [EC:5.3.1.22] subset: gosubset_prok synonym: "hydroxypyruvate aldose-ketose-isomerase activity" EXACT [EC:5.3.1.22] synonym: "hydroxypyruvate ketol-isomerase activity" EXACT [EC:5.3.1.22] xref: EC:5.3.1.22 xref: MetaCyc:RXN0-305 is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0008904 name: aminoglycoside 7''-O-phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = ADP + 7''-O-phosphoaminoglycoside." [EC:2.7.1.119, GOC:cb, GOC:mah] subset: gosubset_prok synonym: "APH(7'') activity" EXACT [EC:2.7.1.119] synonym: "ATP:hygromycin-B 7''-O-phosphotransferase activity" NARROW [EC:2.7.1.119] synonym: "destomic acid ring 7''-O-phosphotransferase activity" EXACT [] synonym: "hygromycin B kinase activity" NARROW [] synonym: "hygromycin B phosphotransferase activity" NARROW [EC:2.7.1.119] synonym: "hygromycin-B kinase activity" NARROW [] xref: EC:2.7.1.119 xref: MetaCyc:HYGROMYCIN-B-KINASE-RXN is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008905 name: mannose-phosphate guanylyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a phosphate group from GTP or GDP to a mannose molecule." [GOC:mah] subset: gosubset_prok xref: EC:2.7.7.- is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0008906 name: inosine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + inosine = ADP + IMP." [EC:2.7.1.73] subset: gosubset_prok synonym: "ATP:inosine 5'-phosphotransferase activity" EXACT [EC:2.7.1.73] synonym: "inosine kinase (phosphorylating)" EXACT [EC:2.7.1.73] synonym: "inosine-guanosine kinase activity" RELATED [EC:2.7.1.73] xref: EC:2.7.1.73 xref: MetaCyc:INOSINEKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008907 name: integrase activity namespace: molecular_function def: "Catalysis of the integration of lambdoid phage DNA during establishment, probably by forming a transient DNA-protein link." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_goa subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008908 name: isochorismatase activity namespace: molecular_function def: "Catalysis of the reaction: isochorismate + H2O = 2,3-dihydro-2,3-dihydroxybenzoate + pyruvate." [EC:3.3.2.1] subset: gosubset_prok synonym: "2,3 dihydro-2,3 dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydro-2,3-dihydroxybenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoate synthase activity" EXACT [EC:3.3.2.1] synonym: "2,3-dihydroxy-2,3-dihydrobenzoic synthase activity" EXACT [EC:3.3.2.1] synonym: "isochorismate pyruvate-hydrolase activity" EXACT [EC:3.3.2.1] xref: EC:3.3.2.1 xref: MetaCyc:ISOCHORMAT-RXN is_a: GO:0004463 ! leukotriene-A4 hydrolase activity [Term] id: GO:0008909 name: isochorismate synthase activity namespace: molecular_function def: "Catalysis of the reaction: chorismate = isochorismate." [EC:5.4.99.6] comment: Note that this function was formerly EC:5.4.99.6. subset: gosubset_prok synonym: "isochorismate hydroxymutase activity" EXACT [EC:5.4.4.2] synonym: "isochorismate mutase activity" EXACT [] synonym: "isochorismate synthetase activity" EXACT [EC:5.4.4.2] xref: EC:5.4.4.2 xref: MetaCyc:ISOCHORSYN-RXN is_a: GO:0050486 ! intramolecular transferase activity, transferring hydroxy groups [Term] id: GO:0008910 name: kanamycin kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + kanamycin = ADP + kanamycin 3'-phosphate." [EC:2.7.1.95] subset: gosubset_prok synonym: "aminoglycoside 3'-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "APH(3') activity" EXACT [EC:2.7.1.95] synonym: "ATP:kanamycin 3'-O-phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "kanamycin kinase (phosphorylating)" EXACT [EC:2.7.1.95] synonym: "neomycin phosphotransferase activity" EXACT [EC:2.7.1.95] synonym: "neomycin-kanamycin phosphotransferase activity" EXACT [EC:2.7.1.95] xref: EC:2.7.1.95 xref: MetaCyc:KANAMYCIN-KINASE-RXN is_a: GO:0034071 ! aminoglycoside phosphotransferase activity [Term] id: GO:0008911 name: lactaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-lactaldehyde + NAD+ + H2O = (S)-lactate + NADH + H+." [EC:1.2.1.22] subset: gosubset_prok synonym: "(S)-lactaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "L-lactaldehyde:NAD oxidoreductase activity" EXACT [EC:1.2.1.22] synonym: "nicotinamide adenine dinucleotide (NAD)-linked dehydrogenase activity" EXACT [EC:1.2.1.22] xref: EC:1.2.1.22 xref: MetaCyc:LACTALDDEHYDROG-RXN is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008912 name: lactaldehyde reductase activity namespace: molecular_function def: "Catalysis of the reaction: (R) (or (S))-propane-1,2-diol + NAD+ = (R) (or (S))-lactaldehyde + NADH + H+." [EC:1.1.1.77] subset: gosubset_prok synonym: "(R)[or (S)]-propane-1,2-diol:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "L-lactaldehyde:propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol oxidoreductase activity" EXACT [EC:1.1.1.77] synonym: "propanediol:nicotinamide adenine dinucleotide (NAD) oxidoreductase activity" EXACT [EC:1.1.1.77] xref: EC:1.1.1.77 xref: MetaCyc:LACTALDREDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008913 name: lauroyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a lauroyl (dodecanoyl) group from one compound to another." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "lauroyl transferase activity" EXACT [] is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008914 name: leucyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: L-leucyl-tRNA + protein = tRNA + L-leucyl-protein." [EC:2.3.2.6] subset: gosubset_prok synonym: "L-leucyl-tRNA:protein leucyltransferase activity" EXACT [EC:2.3.2.6] synonym: "L/F transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl, phenylalanine-tRNA-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein aminoacyltransferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-phenylalanine-transfer ribonucleate-protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] synonym: "leucyl/phenylalanyl-tRNA--protein transferase activity" EXACT [EC:2.3.2.6] xref: EC:2.3.2.6 xref: MetaCyc:LEUCYLTRANSFERASE-RXN is_a: GO:0016755 ! transferase activity, transferring amino-acyl groups [Term] id: GO:0008915 name: lipid-A-disaccharide synthase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine + 2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate = UDP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-2,3-bis(3-hydroxytetradecanoyl)-beta-D-glucosaminyl 1-phosphate." [EC:2.4.1.182] subset: gosubset_prok synonym: "UDP-2,3-bis(3-hydroxytetradecanoyl)glucosamine:2,3-bis-(3-hydroxytetradecanoyl)-beta-D-glucosaminyl-1-phosphate 2,3-bis(3-hydroxytetradecanoyl)-glucosaminyltransferase activity" EXACT [EC:2.4.1.182] xref: EC:2.4.1.182 xref: MetaCyc:LIPIDADISACCHARIDESYNTH-RXN is_a: GO:0008194 ! UDP-glycosyltransferase activity is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008917 name: lipopolysaccharide N-acetylglucosaminyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + lipopolysaccharide = UDP + N-acetyl-D-glucosaminyl-lipopolysaccharide." [EC:2.4.1.56] subset: gosubset_prok synonym: "LPS N-acetylglucosaminyltransferase activity" EXACT [] synonym: "UDP-N-acetyl-D-glucosamine:lipopolysaccharide N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "UDP-N-acetylglucosamine-lipopolysaccharide N-acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] synonym: "uridine diphosphoacetylglucosamine-lipopolysaccharide acetylglucosaminyltransferase activity" EXACT [EC:2.4.1.56] xref: EC:2.4.1.56 xref: MetaCyc:2.4.1.56-RXN is_a: GO:0008375 ! acetylglucosaminyltransferase activity [Term] id: GO:0008918 name: lipopolysaccharide 3-alpha-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,3 alpha-D-galactosyl-lipopolysaccharide." [EC:2.4.1.44] subset: gosubset_prok synonym: "lipopolysaccharide 1,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "lipopolysaccharide galactosyltransferase activity" EXACT [] synonym: "lipopolysaccharide-alpha-1,3-D-galactosyltransferase" NARROW [] synonym: "LPS 3-alpha-galactosyltransferase activity" EXACT [] synonym: "UDP-galactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDP-galactose:polysaccharide galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "UDPgalactose:lipopolysaccharide 3-alpha-D-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphate galactose:lipopolysaccharide alpha-3-galactosyltransferase activity" EXACT [EC:2.4.1.44] synonym: "uridine diphosphogalactose-lipopolysaccharide alpha,3-galactosyltransferase activity" EXACT [EC:2.4.1.44] xref: EC:2.4.1.44 xref: MetaCyc:2.4.1.44-RXN is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008919 name: lipopolysaccharide glucosyltransferase I activity namespace: molecular_function def: "Catalysis of the reaction: UDP-glucose + lipopolysaccharide = UDP + D-glucosyl-lipopolysaccharide." [EC:2.4.1.58] subset: gosubset_prok synonym: "lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "LPS glucosyltransferase I activity" EXACT [] synonym: "UDP-glucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] synonym: "UDPglucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphate glucose:lipopolysaccharide glucosyltransferase I" RELATED [EC:2.4.1.58] synonym: "uridine diphosphoglucose-lipopolysaccharide glucosyltransferase activity" EXACT [EC:2.4.1.58] xref: EC:2.4.1.58 xref: MetaCyc:2.4.1.58-RXN is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0008920 name: lipopolysaccharide heptosyltransferase activity namespace: molecular_function subset: gosubset_prok synonym: "LPS heptosyltransferase activity" EXACT [] is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008921 name: lipopolysaccharide-1,6-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,6 alpha-D-galactosyl-lipopolysaccharide." [GOC:ai] synonym: "LPS-1,6-galactosyltransferase activity" EXACT [] xref: EC:2.4.1.- is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0008922 name: long-chain fatty acid [acyl-carrier-protein] ligase activity namespace: molecular_function alt_id: GO:0010300 def: "Catalysis of the reaction: ATP + an acid + [acyl-carrier protein] = AMP + diphosphate + acyl-[acyl-carrier protein]." [EC:6.2.1.20] subset: gosubset_prok synonym: "acyl-[acyl-carrier-protein] synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-ACP synthetase activity" EXACT [] synonym: "acyl-acyl carrier protein synthetase" BROAD [EC:6.2.1.20] synonym: "acyl-acyl-carrier-protein synthetase activity" EXACT [EC:6.2.1.20] synonym: "acyl-acyl-carrier-proteinsynthetase activity" EXACT [EC:6.2.1.20] synonym: "long-chain fatty acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-[acyl-carrier-protein] ligase activity" EXACT [] synonym: "long-chain-fatty-acid-ACP ligase activity" EXACT [] synonym: "long-chain-fatty-acid-acyl-carrier-protein ligase activity" EXACT [EC:6.2.1.20] synonym: "long-chain-fatty-acid:acyl-carrier-protein ligase (AMP-forming) activity" EXACT [EC:6.2.1.20] synonym: "stearoyl-ACP synthetase activity" EXACT [EC:6.2.1.20] xref: EC:6.2.1.20 xref: MetaCyc:ACYLACPSYNTH-RXN is_a: GO:0015645 ! fatty acid ligase activity is_a: GO:0016878 ! acid-thiol ligase activity [Term] id: GO:0008923 name: lysine decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: L-lysine = cadaverine + CO2." [EC:4.1.1.18] subset: gosubset_prok synonym: "L-lysine carboxy-lyase (cadaverine-forming)" EXACT [EC:4.1.1.18] synonym: "L-lysine carboxy-lyase activity" EXACT [EC:4.1.1.18] xref: EC:4.1.1.18 xref: MetaCyc:LYSDECARBOX-RXN xref: MetaCyc:PWY0-461 is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008924 name: malate dehydrogenase (acceptor) activity namespace: molecular_function def: "Catalysis of the reaction: (S)-malate + acceptor = oxaloacetate + reduced acceptor." [EC:1.1.99.16] subset: gosubset_prok synonym: "(S)-malate:(acceptor) oxidoreductase activity" EXACT [EC:1.1.99.16] synonym: "(S)-malate:acceptor oxidoreductase activity" EXACT [EC:1.1.99.16] synonym: "FAD-dependent malate-vitamin K reductase activity" EXACT [] synonym: "malate-vitamin K reductase activity" EXACT [] xref: EC:1.1.99.16 xref: MetaCyc:MALATE-DEHYDROGENASE-ACCEPTOR-RXN is_a: GO:0016615 ! malate dehydrogenase activity [Term] id: GO:0008925 name: maltose O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + maltose = CoA + acetyl-maltose." [EC:2.3.1.79] subset: gosubset_prok synonym: "acetyl-CoA:maltose O-acetyltransferase activity" EXACT [EC:2.3.1.79] synonym: "maltose transacetylase activity" EXACT [EC:2.3.1.79] xref: EC:2.3.1.79 xref: MetaCyc:MALTACETYLTRAN-RXN is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0008926 name: mannitol-1-phosphate 5-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.17] subset: gosubset_prok xref: EC:1.1.1.17 xref: MetaCyc:MANNPDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0008927 name: mannonate dehydratase activity namespace: molecular_function def: "Catalysis of the reaction: D-mannonate = 2-dehydro-3-deoxy-D-gluconate + H2O." [EC:4.2.1.8] subset: gosubset_prok synonym: "altronate hydrolase activity" EXACT [EC:4.2.1.8] synonym: "altronic hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase (2-dehydro-3-deoxy-D-gluconate-forming)" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydro-lyase activity" EXACT [EC:4.2.1.8] synonym: "D-mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonate hydrolyase activity" EXACT [EC:4.2.1.8] synonym: "mannonic hydrolase activity" EXACT [EC:4.2.1.8] xref: EC:4.2.1.8 xref: MetaCyc:MANNONDEHYDRAT-RXN is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0008928 name: mannose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-mannose 1-phosphate = phosphate + GDP-mannose." [EC:2.7.7.22] subset: gosubset_prok synonym: "GDP mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "GDP-mannose pyrophosphorylase activity" RELATED [EC:2.7.7.22] synonym: "GDP:alpha-D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:D-mannose-1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "GDP:mannose-1-phosphate guanylyltransferase activity" EXACT [] synonym: "guanosine diphosphate-mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "guanosine diphosphomannose phosphorylase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate (guanosine diphosphate) guanylyltransferase activity" EXACT [EC:2.7.7.22] synonym: "mannose 1-phosphate guanylyltransferase activity" EXACT [EC:2.7.7.22] xref: EC:2.7.7.22 xref: MetaCyc:MANNPGUANYLTRANGDP-RXN is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0008929 name: methylglyoxal synthase activity namespace: molecular_function def: "Catalysis of the reaction: glycerone phosphate = methylglyoxal + phosphate." [EC:4.2.3.3] subset: gosubset_prok synonym: "glycerone-phosphate phospho-lyase (methylglyoxal-forming)" EXACT [EC:4.2.3.3] synonym: "glycerone-phosphate phospho-lyase activity" EXACT [EC:4.2.3.3] synonym: "methylglyoxal synthetase activity" EXACT [EC:4.2.3.3] xref: EC:4.2.3.3 xref: MetaCyc:METHGLYSYN-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0008930 name: methylthioadenosine nucleosidase activity namespace: molecular_function def: "Catalysis of the reaction: methylthioadenosine + H2O = adenine + 5-methylthio-D-ribose." [EC:3.2.2.16] subset: gosubset_prok synonym: "5'-methylthioadenosine nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "MeSAdo nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "methylthioadenosine methylthioribohydrolase activity" EXACT [EC:3.2.2.16] synonym: "MTA nucleosidase activity" EXACT [EC:3.2.2.16] synonym: "S-methyl-5'-thioadenosine adeninehyrolase activity" EXACT [EC:3.2.2.16] xref: EC:3.2.2.16 xref: MetaCyc:METHYLTHIOADENOSINE-NUCLEOSIDASE-RXN is_a: GO:0016799 ! hydrolase activity, hydrolyzing N-glycosyl compounds [Term] id: GO:0008931 name: murein DD-endopeptidase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008932 name: lytic endotransglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues. Acts on linkages within peptidoglycan chains (i.e. not at the ends) to produce shorter strands with 1,6-anhydromuramic acid ends." [PMID:10964424, PMID:9642199] synonym: "murein lytic endotransglycosylase E activity" NARROW [] xref: EC:2.4.99.- is_a: GO:0008933 ! lytic transglycosylase activity [Term] id: GO:0008933 name: lytic transglycosylase activity namespace: molecular_function def: "Catalysis of the specific cleavage of the beta-1,4 glycosidic linkage between N-acetylmuramyl and N-acetylglucosaminyl residues in peptidoglycan, with the concomitant formation of 1,6-anhydro-N-acetylmuramyl residues." [PMID:10964424] subset: gosubset_prok synonym: "murein transglycosylase B activity" NARROW [] synonym: "peptidoglycan lytic transglycosylase activity" EXACT [] xref: EC:3.2.1.- is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008934 name: inositol-1(or 4)-monophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: myo-inositol 1-phosphate + H2O = myo-inositol + phosphate." [EC:3.1.3.25] subset: gosubset_prok synonym: "inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "inositol monophosphate phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol phosphatase activity" BROAD [EC:3.1.3.25] synonym: "inositol-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "L-myo-inositol-1-phosphate phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol 1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol monophosphatase activity" BROAD [EC:3.1.3.25] synonym: "myo-inositol-1(or 4)-monophosphatase activity" EXACT [] synonym: "myo-inositol-1(or 4)-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-1-phosphatase activity" EXACT [EC:3.1.3.25] synonym: "myo-inositol-phosphate phosphohydrolase activity" EXACT [EC:3.1.3.25] xref: EC:3.1.3.25 xref: MetaCyc:MYO-INOSITOL-1OR-4-MONOPHOSPHATASE-RXN is_a: GO:0004437 ! inositol or phosphatidylinositol phosphatase activity [Term] id: GO:0008935 name: naphthoate synthase activity namespace: molecular_function def: "Catalysis of the reaction: O-succinylbenzoyl-CoA = 1,4-dihydroxy-2-naphthoate + CoA." [EC:4.1.3.36] subset: gosubset_prok synonym: "1,4-dihydroxy-2-naphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "DHNA synthetase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoate synthase activity" EXACT [EC:4.1.3.36] synonym: "dihydroxynaphthoic acid synthetase activity" EXACT [EC:4.1.3.36] synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing) activity" EXACT [EC:4.1.3.36] synonym: "o-succinylbenzoyl-CoA 1,4-dihydroxy-2-naphthoate-lyase (cyclizing; CoA-forming)" EXACT [EC:4.1.3.36] xref: EC:4.1.3.36 xref: MetaCyc:NAPHTHOATE-SYN-RXN is_a: GO:0016833 ! oxo-acid-lyase activity [Term] id: GO:0008936 name: nicotinamidase activity namespace: molecular_function def: "Catalysis of the reaction: nicotinamide + H2O = nicotinate + NH3." [EC:3.5.1.19] subset: gosubset_prok synonym: "NAMase activity" EXACT [EC:3.5.1.19] synonym: "namase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide amidohydrolase activity" EXACT [EC:3.5.1.19] synonym: "nicotinamide deaminase activity" EXACT [EC:3.5.1.19] synonym: "nicotine deamidase activity" EXACT [EC:3.5.1.19] synonym: "YNDase activity" EXACT [EC:3.5.1.19] xref: EC:3.5.1.19 xref: MetaCyc:NICOTINAMID-RXN xref: Reactome:1714 "nicotinamidase activity" is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008937 name: ferredoxin reductase activity namespace: molecular_function def: "Catalysis of the reactions: reduced ferredoxin + NAD(P)+ = oxidized ferredoxin + NAD(P)H + H+." [EC:1.18.1.-] subset: gosubset_prok xref: EC:1.18.1.- is_a: GO:0016731 ! oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor [Term] id: GO:0008938 name: nicotinate N-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + nicotinate = S-adenosyl-L-homocysteine + N-methylnicotinate." [EC:2.1.1.7] synonym: "furanocoumarin 8-O-methyltransferase activity" EXACT [EC:2.1.1.7] synonym: "S-adenosyl-L-methionine:nicotinate N-methyltransferase activity" EXACT [EC:2.1.1.7] xref: EC:2.1.1.7 xref: MetaCyc:NICOTINATE-N-METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0008939 name: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: beta-nicotinate D-ribonucleotide + dimethylbenzimidazole = nicotinate + N1-(5-phospho-alpha-D-ribosyl)-5,6-dimethylbenzimidazole." [EC:2.4.2.21] subset: gosubset_prok synonym: "CobT" RELATED [EC:2.4.2.21] synonym: "N(1)-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "N1-alpha-phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide (NaMN):5,6-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate mononucleotide-dimethylbenzimidazole phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate ribonucleotide:benzimidazole (adenine) phosphoribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:5,6-dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] synonym: "nicotinate-nucleotide:dimethylbenzimidazole phospho-D-ribosyltransferase activity" EXACT [EC:2.4.2.21] xref: EC:2.4.2.21 xref: MetaCyc:DMBPPRIBOSYLTRANS-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0008940 name: nitrate reductase activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + acceptor = NO3- (nitrate) + reduced acceptor." [EC:1.7.99.4] subset: gosubset_prok synonym: "nitrate reductase (acceptor)" EXACT [EC:1.7.99.4] synonym: "nitrite:(acceptor) oxidoreductase" EXACT [EC:1.7.99.4] synonym: "nitrite:acceptor oxidoreductase" EXACT [EC:1.7.99.4] synonym: "respiratory nitrate reductase activity" NARROW [EC:1.7.99.4] xref: EC:1.7.99.4 xref: MetaCyc:NITRATREDUCT-RXN is_a: GO:0016661 ! oxidoreductase activity, acting on other nitrogenous compounds as donors [Term] id: GO:0008941 name: nitric oxide dioxygenase activity namespace: molecular_function def: "Catalysis of the reaction: 2 NO + 2 O2 + NADPH + H+ = 2 NO3- + NADP+." [EC:1.14.12.17] subset: gosubset_prok synonym: "nitric oxide,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.12.17] synonym: "NOD activity" EXACT [EC:1.14.12.17] xref: EC:1.14.12.17 xref: MetaCyc:R621-RXN is_a: GO:0016708 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of two atoms of oxygen into one donor [Term] id: GO:0008942 name: nitrite reductase [NAD(P)H] activity namespace: molecular_function def: "Catalysis of the reaction: ammonium hydroxide + 3 NAD(P)+ + H2O = NO2(-) (nitrite) + 3 NAD(P)H + 3 H+." [EC:1.7.1.4] comment: Note that this function was formerly EC:1.6.6.4. subset: gosubset_prok synonym: "ammonium-hydroxide:NAD(P)+ oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "assimilatory nitrite reductase activity" RELATED [EC:1.7.1.4] synonym: "NAD(P)H2:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NAD(P)H:nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADH-nitrite oxidoreductase activity" EXACT [EC:1.7.1.4] synonym: "NADPH-nitrite reductase activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase (reduced nicotinamide adenine dinucleotide (phosphate)) activity" EXACT [EC:1.7.1.4] synonym: "nitrite reductase [NAD(P)H2]" RELATED [EC:1.7.1.4] xref: EC:1.7.1.4 xref: MetaCyc:NITRITREDUCT-RXN is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0008943 name: glyceraldehyde-3-phosphate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: glyceraldehyde 3-phosphate + (phosphate / H2O) + NAD(P)+ = (3-phospho-D-glyceroyl-phosphate / 3-phospho-D-glycerate) + NAD(P)H + H+." [EC:1.2.1.12, EC:1.2.1.13, EC:1.2.1.9] comment: Note that the reaction with phosphate as a substrate produces 3-phospho-D-glyceroyl-phosphate. subset: gosubset_prok xref: EC:1.2.1.- is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008944 name: oligopeptidase A activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of oligopeptides, with broad specificity. Gly or Ala commonly occur as P1 or P1' residues, but more distant residues are also important, as is shown by the fact that Z-Gly-Pro-Gly-Gly-Pro-Ala is cleaved at the Gly-Gly bond, but not Z-(Gly)5." [EC:3.4.24.70] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "68000-M signalpeptide hydrolase activity" EXACT [EC:3.4.24.70] xref: EC:3.4.24.70 xref: MetaCyc:3.4.24.70-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008945 name: oligopeptidase B activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Arg-Xaa and Lys-Xaa bonds in oligopeptides, even when P1' residue is proline." [EC:3.4.21.83] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Escherichia coli alkaline proteinase II" RELATED [EC:3.4.21.83] synonym: "protease II activity" EXACT [EC:3.4.21.83] xref: EC:3.4.21.83 xref: MetaCyc:3.4.21.83-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008946 name: oligonucleotidase activity namespace: molecular_function def: "Catalysis of the exonucleolytic cleavage of oligonucleotides to yield nucleoside 5'-phosphates." [EC:3.1.13.3] comment: Note that enzymes with this activity usually also hydrolyze NAD+ to NMN and AMP. subset: gosubset_prok xref: EC:3.1.13.3 xref: MetaCyc:3.1.13.3-RXN is_a: GO:0004518 ! nuclease activity [Term] id: GO:0008947 name: omptin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Xaa-Yaa in which both Xaa and Yaa are Arg or Lys." [EC:3.4.21.87] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.21.87 xref: MetaCyc:3.4.21.87-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008948 name: oxaloacetate decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxaloacetate = pyruvate + CO2." [EC:4.1.1.3] subset: gosubset_prok synonym: "oxalacetic acid decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxalate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate beta-decarboxylase activity" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase (pyruvate-forming)" EXACT [EC:4.1.1.3] synonym: "oxaloacetate carboxy-lyase activity" EXACT [EC:4.1.1.3] xref: EC:4.1.1.3 xref: MetaCyc:OXALODECARB-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008949 name: oxalyl-CoA decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: oxalyl-CoA = formyl-CoA + CO2." [EC:4.1.1.8] subset: gosubset_prok synonym: "oxalyl coenzyme A decarboxylase activity" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase (formyl-CoA-forming)" EXACT [EC:4.1.1.8] synonym: "oxalyl-CoA carboxy-lyase activity" EXACT [EC:4.1.1.8] xref: EC:4.1.1.8 xref: MetaCyc:OXALYL-COA-DECARBOXYLASE-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0008950 name: p-aminobenzoate synthetase namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:krc] comment: This term was made obsolete because it refers to two different functions, a glutamine amidotransferase that functions as an aminodeoxychorismate synthase [itself composed of two enzymatic activities, a glutaminase and a chorismate aminase (this latter is sometimes referred to as the aminodeoxychorismate synthase)] and a 4-amino-4-deoxychorismate aromatase (4-amino-4-deoxychorismate lyase). Note that the name 'para-amino benzoate synthase' was initially given to the 'aminodeoxychorismate synthase' activity before the additional lyase activity was discovered. is_obsolete: true consider: GO:0008696 consider: GO:0046820 [Term] id: GO:0008951 name: palmitoleoyl [acyl-carrier-protein]-dependent acyltransferase activity namespace: molecular_function synonym: "palmitoleoyl ACP-dependent acyltransferase activity" EXACT [] xref: EC:2.3.1.- xref: MetaCyc:PALMITOTRANS-RXN is_a: GO:0008415 ! acyltransferase activity [Term] id: GO:0008953 name: penicillin amidase activity namespace: molecular_function def: "Catalysis of the reaction: penicillin + H2O = a carboxylate + 6-aminopenicillanate." [EC:3.5.1.11] subset: gosubset_prok synonym: "alpha-acylamino-beta-lactam acylhydrolase activity" EXACT [EC:3.5.1.11] synonym: "ampicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "benzylpenicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "novozym 217" RELATED [EC:3.5.1.11] synonym: "palmitoleoyl [acyl-carrier protein]-dependent acyltransferase activity" EXACT [] synonym: "penicillin acylase activity" EXACT [EC:3.5.1.11] synonym: "penicillin amidohydrolase activity" EXACT [EC:3.5.1.11] synonym: "semacylase activity" EXACT [EC:3.5.1.11] xref: EC:3.5.1.11 xref: MetaCyc:PENICILLIN-AMIDASE-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0008954 name: peptidoglycan synthetase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008955 name: peptidoglycan glycosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-diphosphoundecaprenol + GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphosphoundecaprenol = [GlcNAc-(1,4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-diphosphoundecaprenol + undecaprenyl diphosphate." [EC:2.4.1.129] subset: gosubset_prok synonym: "bactoprenyldiphospho-N-acetylmuramoyl-(N-acetyl-D-glucosaminyl)-pentapeptide:peptidoglycan N-acetylmuramoyl-N-acetyl-D-glucosaminyltransferase activity" EXACT [EC:2.4.1.129] synonym: "penicillin binding protein (3 or 1B) activity" NARROW [EC:2.4.1.129] synonym: "peptidoglycan TGase activity" EXACT [EC:2.4.1.129] synonym: "peptidoglycan transglycosylase activity" EXACT [EC:2.4.1.129] synonym: "PG-II activity" EXACT [EC:2.4.1.129] synonym: "undecaprenyldiphospho-N-acetyl-D-glucosaminyl-(1->4)-(N-acetyl-D-muramoylpentapeptide):undecaprenyldiphospho-(N-acetyl-D-glucosaminyl-(1->4)-N-acetyl-D-muramoylpentapeptide) disaccharidetransferase activity" EXACT [EC:2.4.1.129] xref: EC:2.4.1.129 xref: MetaCyc:2.4.1.129-RXN is_a: GO:0016758 ! transferase activity, transferring hexosyl groups [Term] id: GO:0008956 name: peptidyl-dipeptidase Dcp activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of unblocked, C-terminal dipeptides from oligopeptides, with broad specificity. Does not hydrolyze bonds in which P1' is Pro, or both P1 and P1' are Gly." [EC:3.4.15.5] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "dipeptidyl carboxypeptidase (Dcp)" EXACT [EC:3.4.15.5] synonym: "dipeptidyl carboxypeptidase activity" EXACT [EC:3.4.15.5] xref: EC:3.4.15.5 xref: MetaCyc:3.4.15.5-RXN is_obsolete: true replaced_by: GO:0008235 replaced_by: GO:0008241 [Term] id: GO:0008957 name: phenylacetaldehyde dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: phenylacetaldehyde + NAD+ + H2O = phenylacetate + NADH + H+." [EC:1.2.1.39] subset: gosubset_prok synonym: "phenylacetaldehyde:NAD+ oxidoreductase activity" EXACT [EC:1.2.1.39] xref: EC:1.2.1.39 xref: MetaCyc:PHENDEHYD-RXN xref: UM-BBD_enzymeID:e0119 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0008959 name: phosphate acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate." [EC:2.3.1.8] subset: gosubset_prok synonym: "acetyl-CoA:phosphate acetyltransferase activity" EXACT [EC:2.3.1.8] synonym: "phosphoacylase activity" EXACT [EC:2.3.1.8] synonym: "phosphotransacetylase activity" EXACT [EC:2.3.1.8] synonym: "PTA" RELATED [EC:2.3.1.8] xref: EC:2.3.1.8 xref: MetaCyc:PHOSACETYLTRANS-RXN is_a: GO:0016407 ! acetyltransferase activity [Term] id: GO:0008960 name: phosphatidylglycerol-membrane-oligosaccharide glycerophosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerol + membrane-derived-oligosaccharide D-glucose = 1,2-diacyl-sn-glycerol + membrane-derived-oligosaccharide 6-(glycerophospho)-D-glucose." [EC:2.7.8.20] subset: gosubset_prok synonym: "oligosaccharide glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphatidylglycerol:membrane-derived-oligosaccharide-D-glucose glycerophosphotransferase activity" EXACT [EC:2.7.8.20] synonym: "phosphoglycerol transferase activity" RELATED [EC:2.7.8.20] synonym: "phosphoglycerol transferase I" RELATED [EC:2.7.8.20] xref: EC:2.7.8.20 xref: MetaCyc:PGLYCEROLTRANSI-RXN is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008961 name: phosphatidylglycerol-prolipoprotein diacylglyceryl transferase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0016757 ! transferase activity, transferring glycosyl groups [Term] id: GO:0008962 name: phosphatidylglycerophosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylglycerophosphate + H2O = phosphatidylglycerol + phosphate." [EC:3.1.3.27] subset: gosubset_prok synonym: "PGP phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerol phosphate phosphatase activity" EXACT [EC:3.1.3.27] synonym: "phosphatidylglycerophosphate phosphohydrolase activity" EXACT [EC:3.1.3.27] xref: EC:3.1.3.27 xref: MetaCyc:PGPPHOSPHA-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008963 name: phospho-N-acetylmuramoyl-pentapeptide-transferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine + undecaprenyl phosphate = UMP + N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine-diphosphoundecaprenol." [EC:2.7.8.13] comment: Note that EC classifies 'UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimelyl-D-alanyl-D-alanine:undecaprenyl-phosphate transferase activity ; GO:0051992' and 'phospho-N-acetylmuramoyl-pentapeptide-transferase activity ; GO:0008963' under the same EC number, EC:2.7.8.13. subset: gosubset_prok synonym: "MraY transferase activity" NARROW [EC:2.7.8.13] synonym: "phospho-MurNAc-pentapeptide transferase activity" EXACT [EC:2.7.8.13] synonym: "phospho-N-acetylmuramoyl pentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phospho-NAc-muramoyl-pentapeptide translocase (UMP) activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptide translocase activity" EXACT [EC:2.7.8.13] synonym: "phosphoacetylmuramoylpentapeptidetransferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurAc(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala):undecaprenyl-phosphate phospho-N-acetylmuramoyl-pentapeptide-transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gamma-DGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-Ala-gammaDGlu-Lys-DAla-DAla:undecaprenylphosphate transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C(55)-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-L-Ala-D-gamma-Glu-L-Lys-D-Ala-D-Ala:C55-isoprenoid alcohol transferase activity" EXACT [EC:2.7.8.13] synonym: "UDP-MurNAc-pentapeptide phosphotransferase activity" EXACT [EC:2.7.8.13] xref: EC:2.7.8.13 xref: MetaCyc:RXN-8975 is_a: GO:0016780 ! phosphotransferase activity, for other substituted phosphate groups [Term] id: GO:0008964 name: phosphoenolpyruvate carboxylase activity namespace: molecular_function def: "Catalysis of the reaction: phosphate + oxaloacetate = H2O + phosphoenolpyruvate + CO2." [EC:4.1.1.31] subset: gosubset_prok synonym: "PEP carboxylase activity" EXACT [EC:4.1.1.31] synonym: "PEPC" RELATED [EC:4.1.1.31] synonym: "PEPCase activity" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (adding phosphate; phosphoenolpyruvate-forming)" EXACT [EC:4.1.1.31] synonym: "phosphate:oxaloacetate carboxy-lyase (phosphorylating)" EXACT [EC:4.1.1.31] synonym: "phosphoenolpyruvic carboxylase activity" EXACT [EC:4.1.1.31] synonym: "phosphopyruvate (phosphate) carboxylase activity" EXACT [EC:4.1.1.31] xref: EC:4.1.1.31 xref: MetaCyc:PEPCARBOX-RXN is_a: GO:0004611 ! phosphoenolpyruvate carboxykinase activity [Term] id: GO:0008965 name: phosphoenolpyruvate-protein phosphotransferase activity namespace: molecular_function def: "Catalysis of the reaction: phosphoenolpyruvate + protein L-histidine = pyruvate + protein N(pi)-phospho-L-histidine." [EC:2.7.3.9] subset: gosubset_prok synonym: "enzyme I of the phosphotransferase system" NARROW [EC:2.7.3.9] synonym: "phosphoenolpyruvate sugar phosphotransferase enzyme I activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate--protein phosphatase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein factor phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "phosphopyruvate--protein phosphotransferase activity" EXACT [EC:2.7.3.9] synonym: "sugar--PEP phosphotransferase enzyme I activity" NARROW [EC:2.7.3.9] xref: EC:2.7.3.9 xref: MetaCyc:2.7.3.9-RXN is_a: GO:0016775 ! phosphotransferase activity, nitrogenous group as acceptor [Term] id: GO:0008966 name: phosphoglucosamine mutase activity namespace: molecular_function def: "Catalysis of the reaction: D-glucosamine 1-phosphate = D-glucosamine 6-phosphate." [EC:5.4.2.10] subset: gosubset_prok synonym: "alpha-D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] synonym: "D-glucosamine 1,6-phosphomutase activity" EXACT [EC:5.4.2.10] xref: EC:5.4.2.10 xref: MetaCyc:5.4.2.10-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008967 name: phosphoglycolate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: 2-phosphoglycolate + H2O = glycolate + phosphate." [EC:3.1.3.18] subset: gosubset_prok synonym: "2-phosphoglycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "2-phosphoglycolate phosphohydrolase activity" EXACT [EC:3.1.3.18] synonym: "P-glycolate phosphatase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycolate hydrolase activity" EXACT [EC:3.1.3.18] synonym: "phosphoglycollate phosphatase activity" EXACT [EC:3.1.3.18] xref: EC:3.1.3.18 xref: MetaCyc:GPH-RXN is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008968 name: D-sedoheptulose 7-phosphate isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-sedoheptulose-7-phosphate = D-alpha,beta-D-heptose 7-phosphate." [MetaCyc:RXN0-4301, PMID:11279237, PMID:8631969] subset: gosubset_prok synonym: "phosphoheptose isomerase activity" EXACT [] xref: MetaCyc:RXN0-4301 is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008969 name: phosphohistidine phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: phosphohistidine + H2O = histidine + phosphate." [GOC:mah] subset: gosubset_prok xref: EC:3.1.3.- is_a: GO:0016791 ! phosphatase activity [Term] id: GO:0008970 name: phospholipase A1 activity namespace: molecular_function def: "Catalysis of the reaction: phosphatidylcholine + H2O = 2-acylglycerophosphocholine + a carboxylate." [EC:3.1.1.32] subset: gosubset_prok synonym: "phosphatidylcholine 1-acylhydrolase activity" EXACT [EC:3.1.1.32] xref: EC:3.1.1.32 xref: MetaCyc:PHOSPHOLIPASE-A1-RXN is_a: GO:0004091 ! carboxylesterase activity is_a: GO:0004620 ! phospholipase activity [Term] id: GO:0008972 name: phosphomethylpyrimidine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 4-amino-2-methyl-5-phosphomethylpyrimidine = ADP + 4-amino-2-methyl-5-diphosphomethylpyrimidine." [EC:2.7.4.7] subset: gosubset_prok synonym: "ATP:4-amino-2-methyl-5-phosphomethylpyrimidine phosphotransferase activity" EXACT [EC:2.7.4.7] synonym: "hydroxymethylpyrimidine phosphokinase activity" EXACT [EC:2.7.4.7] xref: EC:2.7.4.7 xref: MetaCyc:PYRIMSYN3-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008973 name: phosphopentomutase activity namespace: molecular_function def: "Catalysis of the reaction: D-ribose 1-phosphate = D-ribose 5-phosphate." [EC:5.4.2.7] subset: gosubset_prok synonym: "alpha-D-glucose-1,6-bisphosphate:deoxy-D-ribose-1-phosphate phosphotransferase activity" EXACT [EC:5.4.2.7] synonym: "alpha-D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "D-ribose 1,5-phosphomutase activity" EXACT [EC:5.4.2.7] synonym: "deoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "deoxyribose phosphomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphodeoxyribomutase activity" RELATED [EC:5.4.2.7] synonym: "phosphoribomutase activity" EXACT [EC:5.4.2.7] xref: EC:5.4.2.7 xref: MetaCyc:PPENTOMUT-RXN is_a: GO:0016868 ! intramolecular transferase activity, phosphotransferases [Term] id: GO:0008974 name: phosphoribulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-ribulose 5-phosphate = ADP + D-ribulose 1,5-bisphosphate." [EC:2.7.1.19] subset: gosubset_prok synonym: "5-phosphoribulose kinase activity" EXACT [EC:2.7.1.19] synonym: "ATP:D-ribulose-5-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.19] synonym: "phosphopentokinase activity" RELATED [EC:2.7.1.19] synonym: "phosphoribulokinase (phosphorylating)" EXACT [EC:2.7.1.19] synonym: "PKK" RELATED [EC:2.7.1.19] synonym: "PRK" RELATED [EC:2.7.1.19] synonym: "PRuK" RELATED [EC:2.7.1.19] synonym: "ribulose phosphate kinase activity" EXACT [EC:2.7.1.19] synonym: "ribulose-5-phosphate kinase activity" EXACT [EC:2.7.1.19] xref: EC:2.7.1.19 xref: MetaCyc:PHOSPHORIBULOKINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0008975 name: pitrilysin activity namespace: molecular_function def: "OBSOLETE. Catalysis of the preferential cleavage of Tyr16-Leu17 and Phe25-Tyr26 bonds of oxidized insulin B chain. Also acts on other substrates of Molecular weight less than 7 kDa such as insulin and glucagon." [EC:3.4.24.55] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "Escherichia coli metalloproteinase Pi" RELATED [EC:3.4.24.55] synonym: "Escherichia coli protease III" RELATED [EC:3.4.24.55] synonym: "protease III activity" EXACT [EC:3.4.24.55] synonym: "protease Pi activity" EXACT [EC:3.4.24.55] synonym: "proteinase Pi" RELATED [EC:3.4.24.55] synonym: "PTR" RELATED [EC:3.4.24.55] xref: EC:3.4.24.55 xref: MetaCyc:3.4.24.55-RXN is_obsolete: true replaced_by: GO:0004222 [Term] id: GO:0008976 name: polyphosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1)." [EC:2.7.4.1] subset: gosubset_prok synonym: "ATP-polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "ATP:polyphosphate phosphotransferase activity" EXACT [EC:2.7.4.1] synonym: "polyphosphate polymerase activity" EXACT [GOC:curators] synonym: "polyphosphoric acid kinase activity" EXACT [EC:2.7.4.1] xref: EC:2.7.4.1 xref: MetaCyc:POLYPHOSPHATE-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0008977 name: prephenate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: prephenate + NAD+ = 4-hydroxyphenylpyruvate + CO2 + NADH + H+." [EC:1.3.1.12] subset: gosubset_prok synonym: "chorismate mutase--prephenate dehydrogenase activity" EXACT [EC:1.3.1.12] synonym: "hydroxyphenylpyruvate synthase activity" BROAD [EC:1.3.1.12] synonym: "prephenate:NAD+ oxidoreductase (decarboxylating)" EXACT [EC:1.3.1.12] xref: EC:1.3.1.12 xref: MetaCyc:PREPHENATEDEHYDROG-RXN is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0008978 name: prepilin peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group, the methyl donor being S-adenosyl-L-methionine." [EC:3.4.23.43] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok xref: EC:3.4.23.43 xref: MetaCyc:3.4.23.43-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0008979 name: prophage integrase activity namespace: molecular_function subset: gosubset_prok is_a: GO:0008907 ! integrase activity [Term] id: GO:0008980 name: propionate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + propanoate = ADP + propanoyl phosphate." [EC:2.7.2.15] subset: gosubset_prok synonym: "ATP:propanoate phosphotransferase activity" EXACT [] synonym: "PduW" RELATED [] synonym: "propanoate kinase activity" EXACT [] synonym: "TdcD" RELATED [] xref: EC:2.7.2.15 is_a: GO:0016301 ! kinase activity is_a: GO:0016774 ! phosphotransferase activity, carboxyl group as acceptor [Term] id: GO:0008981 name: protease IV activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008982 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase activity namespace: molecular_function alt_id: GO:0015455 alt_id: GO:0015456 def: "Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport." [EC:2.7.1.69, GOC:mtg_transport, http://www.ucs.mun.ca/~n55lrb/general_pts.html, ISBN:0815340729, TC:4.A.-.-.-] subset: gosubset_prok synonym: "enzyme II of the phosphotransferase system" NARROW [EC:2.7.1.69] synonym: "enzyme IIl4ac" RELATED [EC:2.7.1.69] synonym: "gene bglC RNA formation factors" RELATED [EC:2.7.1.69] synonym: "gene glC proteins" RELATED [EC:2.7.1.69] synonym: "group translocator activity" RELATED [EC:2.7.1.69] synonym: "PEP--sugar phosphotransferase enzyme II activity" NARROW [EC:2.7.1.69] synonym: "PEP-dependent phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphoenolpyruvate-sugar phosphotransferase enzyme II" RELATED [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphoribosyltransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphohistidinoprotein-hexose phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphoprotein factor-hexose phosophotransferase activity" EXACT [EC:2.7.1.69] synonym: "phosphotransfer-driven group translocator" EXACT [] synonym: "phosphotransferase, phosphohistidinoprotein-hexose activity" EXACT [EC:2.7.1.69] synonym: "protein, specific or class, gene bglC" RELATED [EC:2.7.1.69] synonym: "protein-Np-phosphohistidine-sugar phosphotransferase activity" EXACT [] synonym: "protein-Npi-phospho-L-histidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phospho-L-histidine:sugar Npi-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine-sugar phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "protein-Npi-phosphohistidine:sugar N-pros-phosphotransferase activity" EXACT [EC:2.7.1.69] synonym: "PTS permease activity" EXACT [EC:2.7.1.69] synonym: "PTS transporter" RELATED [EC:2.7.1.69] synonym: "ribonucleic acid formation factor, gene glC" RELATED [EC:2.7.1.69] synonym: "sucrose phosphotransferase system II" RELATED [EC:2.7.1.69] xref: EC:2.7.1.69 xref: MetaCyc:2.7.1.69-RXN is_a: GO:0015144 ! carbohydrate transmembrane transporter activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0022804 ! active transmembrane transporter activity [Term] id: GO:0008983 name: protein-glutamate O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamate = S-adenosyl-L-homocysteine + protein L-glutamate 5-methyl ester; this reaction is the methylation of peptidyl-L-glutamate to form peptidyl-L-glutamate 5-methyl ester." [EC:2.1.1.80, RESID:AA0072] subset: gosubset_prok synonym: "MCP methyltransferase I" RELATED [EC:2.1.1.80] synonym: "MCP methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein methyltransferase II" RELATED [EC:2.1.1.80] synonym: "methyl-accepting chemotaxis protein O-methyltransferase activity" NARROW [EC:2.1.1.80] synonym: "protein carboxyl-methylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxyl-O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxylmethyltransferase II" RELATED [EC:2.1.1.80] synonym: "protein carboxymethylase activity" EXACT [EC:2.1.1.80] synonym: "protein carboxymethyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein methylase II" RELATED [EC:2.1.1.80] synonym: "protein O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(aspartate)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "protein(carboxyl)methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosyl-L-methionine:protein-L-glutamate O-methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine-glutamyl methyltransferase activity" EXACT [EC:2.1.1.80] synonym: "S-adenosylmethionine:protein-carboxyl O-methyltransferase activity" EXACT [EC:2.1.1.80] xref: EC:2.1.1.80 xref: MetaCyc:CHER-RXN xref: RESID:AA0072 is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0051998 ! protein carboxyl O-methyltransferase activity [Term] id: GO:0008984 name: protein-glutamate methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein L-glutamate O(5)-methyl ester + H2O = protein L-glutamate + methanol." [EC:3.1.1.61, RESID:AA0072] subset: gosubset_prok synonym: "CheB methylesterase activity" NARROW [EC:3.1.1.61] synonym: "chemotaxis-specific methylesterase activity" NARROW [EC:3.1.1.61] synonym: "methyl-accepting chemotaxis protein methyl-esterase activity" NARROW [EC:3.1.1.61] synonym: "methylesterase CheB activity" NARROW [EC:3.1.1.61] synonym: "protein-L-glutamate-5-O-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] synonym: "protein-L-glutamate-O5-methyl-ester acylhydrolase activity" EXACT [EC:3.1.1.61] xref: EC:3.1.1.61 xref: MetaCyc:MCPMETEST-RXN xref: RESID:AA0072 is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0008985 name: pyruvate dehydrogenase (cytochrome) activity namespace: molecular_function def: "Catalysis of the reaction: pyruvate + ferricytochrome b1 + H2O = CO2 + acetate + ferrocytochrome b1." [EC:1.2.2.2] subset: gosubset_prok synonym: "pyruvate:ferricytochrome-b1 oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvate:ubiquinone-8-oxidoreductase activity" EXACT [EC:1.2.2.2] synonym: "pyruvic (cytochrome b1) dehydrogenase activity" EXACT [EC:1.2.2.2] xref: EC:1.2.2.2 xref: MetaCyc:PYRUVOXID-RXN is_a: GO:0004738 ! pyruvate dehydrogenase activity is_a: GO:0016622 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, cytochrome as acceptor [Term] id: GO:0008986 name: pyruvate, water dikinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + pyruvate + H2O = AMP + phosphoenolpyruvate + phosphate." [EC:2.7.9.2] subset: gosubset_prok synonym: "ATP:pyruvate, water phosphotransferase activity" EXACT [EC:2.7.9.2] synonym: "PEP synthase activity" EXACT [] synonym: "PEP synthetase activity" EXACT [EC:2.7.9.2] synonym: "phoephoenolpyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvate synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphoenolpyruvic synthase activity" EXACT [EC:2.7.9.2] synonym: "phosphopyruvate synthetase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate,water dikinase activity" EXACT [EC:2.7.9.2] synonym: "pyruvate-water dikinase (phosphorylating)" EXACT [EC:2.7.9.2] synonym: "water pyruvate dikinase activity" EXACT [] xref: EC:2.7.9.2 xref: MetaCyc:PEPSYNTH-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016781 ! phosphotransferase activity, paired acceptors [Term] id: GO:0008987 name: quinolinate synthetase A activity namespace: molecular_function def: "Catalysis of the reaction: iminoaspartate + dihydroxy-acetone-phosphate = quinolinate + 2 H2O + phosphate." [GOC:jl, MetaCyc:QUINOLINATE-SYNTHA-RXN] subset: gosubset_prok xref: MetaCyc:QUINOLINATE-SYNTHA-RXN is_a: GO:0003824 ! catalytic activity [Term] id: GO:0008988 name: rRNA (adenine-N6-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N6-methyladenine." [EC:2.1.1.48] subset: gosubset_prok synonym: "ErmC 23S rRNA methyltransferase" NARROW [EC:2.1.1.48] synonym: "gene ksgA methyltransferase" NARROW [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N(6)) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribonucleic acid-adenine (N6) methylase activity" EXACT [EC:2.1.1.48] synonym: "ribosomal ribonucleate adenine 6-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-6-N-)-methyltransferase activity" EXACT [EC:2.1.1.48] synonym: "S-adenosyl-L-methionine:rRNA (adenine-N6-)-methyltransferase activity" EXACT [EC:2.1.1.48] xref: EC:2.1.1.48 xref: MetaCyc:RRNA-ADENINE-N6--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016433 ! rRNA (adenine) methyltransferase activity [Term] id: GO:0008989 name: rRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N1-methylguanine." [EC:2.1.1.51] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.51] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.51] xref: EC:2.1.1.51 xref: MetaCyc:RRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008990 name: rRNA (guanine-N2-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine." [EC:2.1.1.52] subset: gosubset_prok synonym: "ribosomal ribonucleate guanine-2-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-2-N-)-methyltransferase activity" EXACT [EC:2.1.1.52] synonym: "S-adenosyl-L-methionine:rRNA (guanine-N2-)-methyltransferase activity" EXACT [EC:2.1.1.52] xref: EC:2.1.1.52 xref: MetaCyc:RRNA-GUANINE-N2--METHYLTRANSFERASE-RXN is_a: GO:0008170 ! N-methyltransferase activity is_a: GO:0016435 ! rRNA (guanine) methyltransferase activity [Term] id: GO:0008991 name: serine-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by a serine endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. xref: EC:3.4.21.- is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008992 name: repressor LexA activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of Ala-Gly bond in repressor lexA." [EC:3.4.21.88] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "LexA repressor" RELATED [EC:3.4.21.88] synonym: "repressor lexA" RELATED [EC:3.4.21.88] xref: EC:3.4.21.88 xref: MetaCyc:3.4.21.88-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0008993 name: rhamnulokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-rhamnulose = ADP + L-rhamnulose 1-phosphate." [EC:2.7.1.5] subset: gosubset_prok synonym: "ATP:L-rhamnulose 1-phosphotransferase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulokinase activity" EXACT [EC:2.7.1.5] synonym: "L-rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "rhamnulokinase (phosphorylating)" EXACT [EC:2.7.1.5] synonym: "rhamnulose kinase activity" EXACT [EC:2.7.1.5] synonym: "RhuK" RELATED [EC:2.7.1.5] xref: EC:2.7.1.5 xref: MetaCyc:RHAMNULOKIN-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0008994 name: rhamnulose-1-phosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: L-rhamnulose 1-phosphate = glycerone phosphate + (S)-lactaldehyde." [EC:4.1.2.19] subset: gosubset_prok synonym: "L-rhamnulose 1-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate lactaldehyde-lyase activity" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-1-phosphate S-lactaldehyde-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.19] synonym: "L-rhamnulose-phosphate aldolase activity" EXACT [EC:4.1.2.19] synonym: "rhamnulose phosphate aldolase activity" EXACT [EC:4.1.2.19] xref: EC:4.1.2.19 xref: MetaCyc:RHAMNULPALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0008995 name: ribonuclease E activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at 5 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok xref: MetaCyc:3.1.26.12-RXN is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008996 name: ribonuclease G activity namespace: molecular_function def: "Catalysis of the cleavage of single-stranded RNA that is monophosphorylated at its 5'-end; cleavage occurs predominantly at positions 5 and 6 nucleotides from the 5'-end and in A + U-rich regions, and is blocked by the presence of a 5'-triphosphate group." [PMID:10722715, PMID:16854990] subset: gosubset_prok is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008997 name: ribonuclease R activity namespace: molecular_function def: "Catalysis of the reaction: RNA + H2O = 5'-phosphomononucleotides. Cleaves RNA in the 3' to 5' direction, leaving an undigested core of 3-5 nucleotides." [PMID:11948193] subset: gosubset_prok xref: EC:3.1.11.- is_a: GO:0004540 ! ribonuclease activity [Term] id: GO:0008998 name: ribonucleoside-triphosphate reductase activity namespace: molecular_function def: "Catalysis of the reaction: 2'-deoxyribonucleoside triphosphate + thioredoxin disulfide + H2O = ribonucleoside triphosphate + thioredoxin." [EC:1.17.4.2] subset: gosubset_prok synonym: "2'-deoxyribonucleoside-triphosphate:oxidized-thioredoxin 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "2'-deoxyribonucleoside-triphosphate:thioredoxin-disulfide 2'-oxidoreductase activity" EXACT [EC:1.17.4.2] synonym: "ribonucleotide reductase activity" BROAD [EC:1.17.4.2] xref: EC:1.17.4.2 xref: MetaCyc:1.17.4.2-RXN is_a: GO:0016728 ! oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor [Term] id: GO:0008999 name: ribosomal-protein-alanine N-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + ribosomal-protein L-alanine = CoA + ribosomal-protein N-acetyl-L-alanine." [EC:2.3.1.128] subset: gosubset_prok synonym: "acetyl-CoA:ribosomal-protein-L-alanine N-acetyltransferase activity" EXACT [EC:2.3.1.128] synonym: "ribosomal protein S18 acetyltransferase activity" EXACT [EC:2.3.1.128] xref: EC:2.3.1.128 xref: MetaCyc:2.3.1.128-RXN is_a: GO:0004596 ! peptide alpha-N-acetyltransferase activity [Term] id: GO:0009000 name: selenocysteine lyase activity namespace: molecular_function def: "Catalysis of the reaction: L-selenocysteine + reduced acceptor = hydrogen selenide + L-alanine + acceptor." [EC:4.4.1.16] subset: gosubset_prok synonym: "L-selenocysteine selenide-lyase (L-alanine-forming)" EXACT [EC:4.4.1.16] synonym: "selenocysteine beta-lyase activity" EXACT [EC:4.4.1.16] synonym: "selenocysteine reductase activity" EXACT [EC:4.4.1.16] xref: EC:4.4.1.16 xref: MetaCyc:SELENOCYSTEINE-LYASE-RXN is_a: GO:0016846 ! carbon-sulfur lyase activity [Term] id: GO:0009001 name: serine O-acetyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: acetyl-CoA + L-serine = CoA + O-acetyl-L-serine." [EC:2.3.1.30] subset: gosubset_prok synonym: "acetyl-CoA:L-serine O-acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "L-serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "SATase activity" EXACT [EC:2.3.1.30] synonym: "serine acetyltransferase activity" EXACT [EC:2.3.1.30] synonym: "serine transacetylase activity" EXACT [EC:2.3.1.30] xref: EC:2.3.1.30 xref: MetaCyc:SERINE-O-ACETTRAN-RXN is_a: GO:0016412 ! serine O-acyltransferase activity is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0009002 name: serine-type D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the reaction: (Ac)2-L-Lys-D-alanyl-D-alanine + H2O = (Ac)2-L-Lys-D-alanine + D-alanine." [EC:3.4.16.4] subset: gosubset_prok synonym: "D-alanine carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "D-alanyl carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-carboxypeptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving peptidase activity" EXACT [EC:3.4.16.4] synonym: "D-alanyl-D-alanine-cleaving-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.16.4] synonym: "DD-peptidase activity" EXACT [EC:3.4.16.4] synonym: "DD-transpeptidase activity" EXACT [EC:3.4.16.4] xref: EC:3.4.16.4 xref: MetaCyc:3.4.16.4-RXN is_a: GO:0004185 ! serine-type carboxypeptidase activity [Term] id: GO:0009003 name: signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. is_obsolete: true replaced_by: GO:0008233 [Term] id: GO:0009004 name: signal peptidase I activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from secreted and periplasmic proteins precursor." [EC:3.4.21.89] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "bacterial leader peptidase 1" RELATED [EC:3.4.21.89] synonym: "bacterial leader peptidase I activity" NARROW [EC:3.4.21.89] synonym: "Escherichia coli leader peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "eukaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "HOSP" RELATED [EC:3.4.21.89] synonym: "leader peptidase activity" EXACT [EC:3.4.21.89] synonym: "leader peptidase I" RELATED [EC:3.4.21.89] synonym: "leader peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "leader proteinase activity" EXACT [EC:3.4.21.89] synonym: "phage-procoat-leader peptidase activity" NARROW [EC:3.4.21.89] synonym: "pilin leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic leader peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal peptidase" NARROW [EC:3.4.21.89] synonym: "prokaryotic signal proteinase" NARROW [EC:3.4.21.89] synonym: "propeptidase activity" EXACT [EC:3.4.21.89] synonym: "PuIO prepilin peptidase" NARROW [EC:3.4.21.89] synonym: "signal peptide hydrolase activity" EXACT [EC:3.4.21.89] synonym: "signal proteinase activity" EXACT [EC:3.4.21.89] synonym: "signalase activity" EXACT [EC:3.4.21.89] synonym: "SPase I activity" EXACT [EC:3.4.21.89] synonym: "SPC" RELATED [EC:3.4.21.89] xref: EC:3.4.21.89 xref: MetaCyc:3.4.21.89-RXN is_obsolete: true replaced_by: GO:0004252 [Term] id: GO:0009005 name: signal peptidase II activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of N-terminal leader sequences from membrane prolipoproteins. Hydrolyzes the terminal bond of Xaa-Xbb-Xbb-Cys, in which Xaa is hydrophobic (preferably Leu), Xbb is often Ser or Ala, Xcc is often Gly or Ala, and the Cys is alkylated on sulfur with a diacylglyceryl group." [EC:3.4.23.36] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok synonym: "leader peptidase II" RELATED [EC:3.4.23.36] synonym: "lipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "premurein leader proteinase activity" EXACT [EC:3.4.23.36] synonym: "premurein-leader peptidase activity" NARROW [EC:3.4.23.36] synonym: "prolipoprotein signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "prolipoprotein-signal peptidase activity" EXACT [EC:3.4.23.36] synonym: "SPase II activity" EXACT [EC:3.4.23.36] xref: EC:3.4.23.36 xref: MetaCyc:3.4.23.36-RXN is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009006 name: siroheme synthase activity namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because it represents three different molecular functions. synonym: "sirohaem synthase activity" EXACT [] is_obsolete: true consider: GO:0004851 consider: GO:0019354 consider: GO:0043115 consider: GO:0051266 [Term] id: GO:0009007 name: site-specific DNA-methyltransferase (adenine-specific) activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine." [EC:2.1.1.72] subset: gosubset_prok synonym: "DNA adenine methylase" BROAD [] synonym: "EcoRI methylase" NARROW [EC:2.1.1.37, EC:2.1.1.72] synonym: "modification methylase activity" RELATED [EC:2.1.1.72] synonym: "N-6 adenine-specific DNA methylase activity" EXACT [EC:2.1.1.72] synonym: "restriction-modification system activity" RELATED [EC:2.1.1.72] xref: EC:2.1.1.72 xref: MetaCyc:2.1.1.72-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0009008 ! DNA-methyltransferase activity relationship: part_of GO:0032775 ! DNA methylation on adenine [Term] id: GO:0009008 name: DNA-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to a DNA molecule." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleate methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleate methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methylase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid methyltransferase activity" EXACT [EC:2.1.1.-] synonym: "deoxyribonucleic acid modification methylase activity" RELATED [EC:2.1.1.-] synonym: "DNA methylase" BROAD [] synonym: "DNA methyltransferase activity" EXACT [] synonym: "DNA transmethylase activity" EXACT [EC:2.1.1.-] synonym: "Type II DNA methylase" RELATED [EC:2.1.1.37] xref: EC:2.1.1.- is_a: GO:0008168 ! methyltransferase activity relationship: part_of GO:0006306 ! DNA methylation [Term] id: GO:0009009 name: site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences." [GOC:elh] comment: Note that this term is not a child of 'recombinase activity ; GO:0000150' because the latter represents activities that do not break or form phosphodiester bonds. subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009010 name: sorbitol-6-phosphate 2-dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: D-sorbitol 6-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+." [EC:1.1.1.140] subset: gosubset_prok synonym: "D-glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol 6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "D-sorbitol-6-phosphate:NAD+ 2-oxidoreductase activity" EXACT [EC:1.1.1.140] synonym: "glucitol-6-phosphate dehydrogenase activity" EXACT [EC:1.1.1.140] synonym: "ketosephosphate reductase activity" EXACT [EC:1.1.1.140] synonym: "sorbitol-6-P-dehydrogenase activity" EXACT [EC:1.1.1.140] xref: EC:1.1.1.140 xref: MetaCyc:SORB6PDEHYDROG-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009011 name: starch synthase activity namespace: molecular_function def: "Catalysis of the reaction: ADP-glucose + (1,4)-alpha-D-glucosyl(n) = ADP + (1,4)-alpha-D-glucosyl(n+1)." [EC:2.4.1.21] subset: gosubset_prok synonym: "adenosine diphosphate glucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "adenosine diphosphoglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose starch synthase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose transglucosylase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose--starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADP-glucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPG starch synthetase activity" EXACT [EC:2.4.1.21] synonym: "ADPG-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose-starch glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "ADPglucose:1,4-alpha-D-glucan 4-alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.21] synonym: "glycogen synthase activity" EXACT [EC:2.4.1.21] synonym: "starch (bacterial glycogen) synthase activity" NARROW [EC:2.4.1.21] synonym: "starch synthetase activity" EXACT [EC:2.4.1.21] xref: EC:2.4.1.21 xref: MetaCyc:GLYCOGENSYN-RXN is_a: GO:0046527 ! glucosyltransferase activity [Term] id: GO:0009012 name: aminoglycoside 3''-adenylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + aminoglycoside = diphosphate + 3''-adenylylaminoglycoside." [EC:2.7.7.47, GOC:cb] subset: gosubset_prok synonym: "AAD (3'')" RELATED [EC:2.7.7.47] synonym: "ATP:streptomycin 3''-adenylyltransferase activity" NARROW [] synonym: "streptomycin 3''-adenylyltransferase activity" NARROW [] xref: EC:2.7.7.47 xref: MetaCyc:STREPTOMYCIN-3-ADENYLYLTRANSFERASE-RXN is_a: GO:0034068 ! aminoglycoside nucleotidyltransferase activity [Term] id: GO:0009013 name: succinate-semialdehyde dehydrogenase [NAD(P)+] activity namespace: molecular_function def: "Catalysis of the reaction: succinate semialdehyde + NAD(P)+ + H2O = succinate + NAD(P)H + H+." [EC:1.2.1.16] subset: gosubset_prok synonym: "succinate semialdehyde dehydrogenase (nicotinamide adenine dinucleotide (phosphate))" EXACT [EC:1.2.1.16] synonym: "succinate-semialdehyde:NAD(P)+ oxidoreductase activity" EXACT [EC:1.2.1.16] xref: EC:1.2.1.16 xref: MetaCyc:SUCCSEMIALDDEHYDROG-RXN xref: UM-BBD_enzymeID:e0020 is_a: GO:0016620 ! oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [Term] id: GO:0009014 name: succinyl-diaminopimelate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-LL-2,6-diaminoheptanedioate + H2O = succinate + LL-2,6-diaminoheptanedioate." [EC:3.5.1.18] subset: gosubset_prok synonym: "N-succinyl-L-alpha,epsilon-diaminopimelic acid deacylase activity" EXACT [EC:3.5.1.18] synonym: "N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase activity" EXACT [EC:3.5.1.18] xref: EC:3.5.1.18 xref: MetaCyc:SUCCDIAMINOPIMDESUCC-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009015 name: N-succinylarginine dihydrolase activity namespace: molecular_function def: "Catalysis of the reaction: N2-succinyl-L-arginine + 2 H2O = N2-succinyl-L-ornithine + 2 NH3 + CO." [EC:3.5.3.23] subset: gosubset_prok synonym: "2-N-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [EC:3.5.3.23] synonym: "arginine succinylhydrolase activity" EXACT [] synonym: "AruB" RELATED [] synonym: "AstB" RELATED [] synonym: "N2-succinyl-L-arginine iminohydrolase (decarboxylating)" EXACT [] synonym: "N2-succinylarginine dihydrolase activity" EXACT [] synonym: "SADH" RELATED [] synonym: "succinylarginine dihydrolase activity" EXACT [] xref: EC:3.5.3.23 xref: MetaCyc:SUCCARGDIHYDRO-RXN is_a: GO:0016813 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amidines [Term] id: GO:0009016 name: succinyldiaminopimelate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-2,6-diaminoheptanedioate + 2-oxoglutarate = N-succinyl-L-2-amino-6-oxoheptanedioate + L-glutamate." [EC:2.6.1.17] subset: gosubset_prok synonym: "N-succinyl-L-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [EC:2.6.1.17] synonym: "N-succinyl-L-diaminopimelic glutamic transaminase activity" EXACT [EC:2.6.1.17] synonym: "succinyldiaminopimelate aminotransferase activity" EXACT [] synonym: "succinyldiaminopimelate transferase activity" EXACT [EC:2.6.1.17] xref: EC:2.6.1.17 xref: MetaCyc:SUCCINYLDIAMINOPIMTRANS-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009017 name: succinylglutamate desuccinylase activity namespace: molecular_function def: "Catalysis of the reaction: N-succinyl-L-glutamate + H2O = succinate + L-glutamate." [EC:3.5.1.96] subset: gosubset_prok synonym: "AstE" RELATED [] synonym: "N-succinyl-L-glutamate amidohydrolase activity" EXACT [EC:3.5.1.96] synonym: "N2-succinylglutamate desuccinylase activity" EXACT [] synonym: "SGDS" RELATED [] xref: EC:3.5.1.96 xref: MetaCyc:SUCCGLUDESUCC-RXN is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009018 name: sucrose phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: sucrose + phosphate = D-fructose + alpha-D-glucose 1-phosphate." [EC:2.4.1.7] subset: gosubset_prok synonym: "disaccharide glucosyltransferase activity" BROAD [EC:2.4.1.7] synonym: "sucrose glucosyltransferase activity" EXACT [EC:2.4.1.7] synonym: "sucrose:phosphate alpha-D-glucosyltransferase activity" EXACT [EC:2.4.1.7] xref: EC:2.4.1.7 xref: MetaCyc:SUCROSE-PHOSPHORYLASE-RXN is_a: GO:0004645 ! phosphorylase activity [Term] id: GO:0009019 name: tRNA (guanine-N1-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N1-methylguanine." [EC:2.1.1.31] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanine-1-N-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "S-adenosyl-L-methionine:tRNA (guanine-N1-)-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "transfer ribonucleate guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] synonym: "tRNA guanine 1-methyltransferase activity" EXACT [EC:2.1.1.31] xref: EC:2.1.1.31 xref: MetaCyc:TRNA-GUANINE-N1--METHYLTRANSFERASE-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009020 name: tRNA (guanosine-2'-O-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing 2'-O-methylguanosine." [EC:2.1.1.34] subset: gosubset_prok synonym: "S-adenosyl-L-methionine:tRNA (guanosine-2'-O-)-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "S-adenosyl-L-methionine:tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "transfer ribonucleate guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) 2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (Gm18) methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA (guanosine 2')-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine 2'-methyltransferase activity" EXACT [EC:2.1.1.34] synonym: "tRNA guanosine-2'-O-methyltransferase activity" EXACT [EC:2.1.1.34] xref: EC:2.1.1.34 xref: MetaCyc:2.1.1.34-RXN is_a: GO:0016423 ! tRNA (guanine) methyltransferase activity [Term] id: GO:0009021 name: tRNA (uracil-5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing thymine." [EC:2.1.1.35] subset: gosubset_prok synonym: "m5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "M5U-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "ribothymidyl synthase activity" BROAD [EC:2.1.1.35] synonym: "RUMT activity" EXACT [EC:2.1.1.35] synonym: "S-adenosyl-L-methionine:tRNA (uracil-5-)-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "transfer RNA uracil methylase activity" EXACT [EC:2.1.1.35] synonym: "tRNA uracil 5-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m(5)U54-methyltransferase activity" EXACT [EC:2.1.1.35] synonym: "tRNA:m5U54-methyltransferase activity" EXACT [EC:2.1.1.35] xref: EC:2.1.1.35 xref: MetaCyc:TRNA-URACIL-5--METHYLTRANSFERASE-RXN is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity is_a: GO:0016300 ! tRNA (uracil) methyltransferase activity [Term] id: GO:0009022 name: tRNA nucleotidyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: tRNA(n+1) + phosphate = tRNA(n) + a nucleoside diphosphate." [EC:2.7.7.56] comment: Note that, although the enzyme to which this term refers is also known as 'ribonuclease PH', and degrades tRNA in the 3'-5' direction in vivo, the term does not have parentage in the 'nuclease activity' branch of the ontology because both GO and the Enzyme Commission define nuclease activity as a type of hydrolysis. subset: gosubset_prok synonym: "phosphate-dependent exonuclease activity" RELATED [EC:2.7.7.56] synonym: "ribonuclease PH activity" EXACT [EC:2.7.7.56] synonym: "RNase PH activity" EXACT [EC:2.7.7.56] synonym: "tRNA:phosphate nucleotidyltransferase activity" EXACT [EC:2.7.7.56] xref: EC:2.7.7.56 xref: MetaCyc:TRNA-NUCLEOTIDYLTRANSFERASE-RXN is_a: GO:0016779 ! nucleotidyltransferase activity [Term] id: GO:0009023 name: tRNA sulfurtransferase namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: L-cysteine + activated-tRNA = L-serine + tRNA containing a thionucleotide." [EC:2.8.1.4, GOC:go_curators] synonym: "tRNA sulphurtransferase activity" EXACT [] is_obsolete: true replaced_by: GO:0034227 consider: GO:0016783 [Term] id: GO:0009024 name: tagatose-6-phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + D-tagatose 6-phosphate = ADP + D-tagatose 1,6-bisphosphate." [EC:2.7.1.144] subset: gosubset_prok synonym: "ATP:D-tagatose-6-phosphate 1-phosphotransferase activity" EXACT [EC:2.7.1.144] synonym: "phosphotagatokinase activity" EXACT [EC:2.7.1.144] xref: EC:2.7.1.144 xref: MetaCyc:TAGAKIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009025 name: tagatose-bisphosphate aldolase activity namespace: molecular_function def: "Catalysis of the reaction: D-tagatose 1,6-bisphosphate = glycerone phosphate + D-glyceraldehyde 3-phosphate." [EC:4.1.2.40] subset: gosubset_prok synonym: "AgaY" RELATED [] synonym: "AgaZ" RELATED [] synonym: "D-tagatose-1,6-bisphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate D-glyceraldehyde 3-phosphate-lyase (glycerone-phosphate-forming)" EXACT [EC:4.1.2.40] synonym: "D-tagatose-1,6-bisphosphate triosephosphate lyase activity" EXACT [] synonym: "D-tagatose-1xxx,6-bisphosphate triosephosphate lyase activity" EXACT [EC:4.1.2.40] synonym: "KbaY" RELATED [] synonym: "tagatose 1,6-diphosphate aldolase activity" EXACT [EC:4.1.2.40] synonym: "tagatose-1,6-bisphosphate aldolase 1" EXACT [] xref: EC:4.1.2.40 xref: MetaCyc:TAGAALDOL-RXN is_a: GO:0016832 ! aldehyde-lyase activity [Term] id: GO:0009026 name: tagaturonate reductase activity namespace: molecular_function def: "Catalysis of the reaction: D-altronate + NAD+ = D-tagaturonate + NADH + H+." [EC:1.1.1.58] subset: gosubset_prok synonym: "altronate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "altronate oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "altronic oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-altronate:NAD+ 3-oxidoreductase activity" EXACT [EC:1.1.1.58] synonym: "D-tagaturonate reductase activity" EXACT [EC:1.1.1.58] synonym: "tagaturonate dehydrogenase activity" EXACT [EC:1.1.1.58] synonym: "TagUAR" RELATED [EC:1.1.1.58] xref: EC:1.1.1.58 xref: MetaCyc:ALTRO-OXIDOREDUCT-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009027 name: tartrate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: tartrate + NAD+ = oxaloglycolate + NADH + H+." [EC:1.1.1.93] subset: gosubset_prok synonym: "mesotartrate dehydrogenase activity" EXACT [EC:1.1.1.93] synonym: "tartrate:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.93] xref: EC:1.1.1.93 xref: MetaCyc:TARTRATE-DEHYDROGENASE-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009028 name: tartronate-semialdehyde synthase activity namespace: molecular_function def: "Catalysis of the reaction: 2 glyoxylate = tartronate semialdehyde + CO2." [EC:4.1.1.47] subset: gosubset_prok synonym: "glyoxalate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboligase activity" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing)" EXACT [EC:4.1.1.47] synonym: "glyoxylate carboxy-lyase (dimerizing; tartronate-semialdehyde-forming)" EXACT [EC:4.1.1.47] synonym: "glyoxylic carbo-ligase activity" EXACT [EC:4.1.1.47] synonym: "hydroxymalonic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronate semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] synonym: "tartronic semialdehyde carboxylase activity" EXACT [EC:4.1.1.47] xref: EC:4.1.1.47 xref: MetaCyc:GLYOCARBOLIG-RXN is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0009029 name: tetraacyldisaccharide 4'-kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl-(beta-D-1,6)-2,3-bis(3-hydroxytetradecanoyl)-D-glucosaminyl beta-phosphate = ADP + 2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-1,6-beta-D-glucosamine 1,4'-bisphosphate." [EC:2.7.1.130] subset: gosubset_prok synonym: "ATP:2,3,2',3'-tetrakis(3-hydroxytetradecanoyl)-D-glucosaminyl-beta-D-1,6-glucosaminyl-beta-phosphate 4'-O-phosphotransferase activity" EXACT [EC:2.7.1.130] synonym: "lipid-A 4'-kinase activity" RELATED [EC:2.7.1.130] xref: EC:2.7.1.130 xref: MetaCyc:TETRAACYLDISACC4KIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009030 name: thiamin phosphate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + thiamin phosphate = ADP + thiamin diphosphate." [EC:2.7.4.16] subset: gosubset_prok synonym: "ATP:thiamine-phosphate phosphotransferase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphatase activity" EXACT [EC:2.7.4.16] synonym: "thiamin monophosphokinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamin-phosphate kinase activity" EXACT [] synonym: "thiamine-monophosphate kinase activity" EXACT [EC:2.7.4.16] synonym: "thiamine-phosphate kinase activity" EXACT [] xref: EC:2.7.4.16 xref: MetaCyc:THI-P-KIN-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor [Term] id: GO:0009032 name: thymidine phosphorylase activity namespace: molecular_function def: "Catalysis of the reaction: thymidine + phosphate = thymine + 2-deoxy-D-ribose 1-phosphate." [EC:2.4.2.4] subset: gosubset_prok synonym: "animal growth regulators, blood platelet-derived endothelial cell growth factors" RELATED [EC:2.4.2.4] synonym: "blood platelet-derived endothelial cell growth factor" RELATED [EC:2.4.2.4] synonym: "deoxythymidine phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "gliostatins" RELATED [EC:2.4.2.4] synonym: "pyrimidine deoxynucleoside phosphorylase activity" EXACT [EC:2.4.2.4] synonym: "pyrimidine phosphorylase activity" BROAD [EC:2.4.2.4] synonym: "thymidine-orthophosphate deoxyribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-alpha-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] synonym: "thymidine:phosphate deoxy-D-ribosyltransferase activity" EXACT [EC:2.4.2.4] xref: EC:2.4.2.4 xref: MetaCyc:THYM-PHOSPH-RXN is_a: GO:0016763 ! transferase activity, transferring pentosyl groups [Term] id: GO:0009033 name: trimethylamine-N-oxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: NADH + H+ + trimethylamine-N-oxide = NAD+ + trimethylamine + H2O." [EC:1.6.6.9] subset: gosubset_prok synonym: "NADH:trimethylamine-N-oxide oxidoreductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine N-oxide reductase" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxidase activity" EXACT [EC:1.6.6.9] synonym: "trimethylamine oxide reductase" EXACT [EC:1.6.6.9] xref: EC:1.6.6.9 xref: MetaCyc:TMAOREDUCT-RXN is_a: GO:0016657 ! oxidoreductase activity, acting on NADH or NADPH, nitrogenous group as acceptor [Term] id: GO:0009034 name: tryptophanase activity namespace: molecular_function def: "Catalysis of the reaction: L-tryptophan + H2O = indole + pyruvate + NH3." [EC:4.1.99.1] comment: Note that this term has a MetaCyc pathway reference as the pathway only has a single step. subset: gosubset_prok synonym: "L-tryptophan indole-lyase (deaminating) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase (deaminating; pyruvate forming) activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophan indole-lyase activity" EXACT [EC:4.1.99.1] synonym: "L-tryptophanase activity" EXACT [EC:4.1.99.1] synonym: "TNase activity" EXACT [EC:4.1.99.1] synonym: "tryptophan catabolic process, using tryptophanase" RELATED [EC:4.1.99.1] synonym: "tryptophan catabolism, using tryptophanase" RELATED [EC:4.1.99.1] xref: EC:4.1.99.1 xref: MetaCyc:TRYPDEG-PWY xref: MetaCyc:TRYPTOPHAN-RXN is_a: GO:0016830 ! carbon-carbon lyase activity [Term] id: GO:0009035 name: Type I site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give random double-stranded fragments with terminal 5' or 3' protrusions; ATP is simultaneously hydrolyzed. Cleavage is dependent on the presence in the DNA of a specific recognition site. Cleavage may occur hundreds or thousands of base pairs away from the recognition site due to translocation of DNA." [EC:3.1.21.3, PMID:15788748] subset: gosubset_prok synonym: "adenosine triphosphate-dependent deoxyribonuclease activity" EXACT [EC:3.1.21.3] synonym: "ATP-dependent DNase activity" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (adenosine triphosphate-hydrolyzing)" EXACT [EC:3.1.21.3] synonym: "deoxyribonuclease (ATP- and S-adenosyl-L-methionine-dependent)" EXACT [EC:3.1.21.3] synonym: "Type I restriction enzyme activity" EXACT [] synonym: "type I site-specific deoxyribonuclease activity" EXACT [EC:3.1.21.3] xref: EC:3.1.21.3 xref: MetaCyc:3.1.21.3-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009036 name: Type II site-specific deoxyribonuclease activity namespace: molecular_function def: "Catalysis of the endonucleolytic cleavage of DNA to give specific double-stranded fragments with terminal 5'-phosphates and 3' hydroxyls. Cleavage is dependent on the presence in the DNA of a specific recognition site; cleavage occurs at or very near this recognition site." [EC:3.1.21.4, PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme activity" EXACT [] xref: EC:3.1.21.4 xref: MetaCyc:3.1.21.4-RXN is_a: GO:0015666 ! restriction endodeoxyribonuclease activity is_a: GO:0016888 ! endodeoxyribonuclease activity, producing 5'-phosphomonoesters [Term] id: GO:0009037 name: tyrosine-based site-specific recombinase activity namespace: molecular_function def: "Catalysis of the formation of new phosphodiester bonds between a pair of short, unique DNA target sequences; occurs through a phosphotyrosyl intermediate in which the target sequence is first cleaved by the nucleophilic attack by a tyrosine in the active site." [GOC:elh, PMID:11090626] subset: gosubset_prok synonym: "site-specific tyrosine recombinase activity" EXACT [] synonym: "tyrosine recombinase" BROAD [] is_a: GO:0008907 ! integrase activity is_a: GO:0009009 ! site-specific recombinase activity [Term] id: GO:0009038 name: undecaprenol kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + undecaprenol = ADP + undecaprenyl phosphate." [EC:2.7.1.66] subset: gosubset_prok synonym: "ATP:undecaprenol phosphotransferase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "C55-isoprenyl alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase (phosphorylating)" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol kinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid alcohol phosphokinase activity" EXACT [EC:2.7.1.66] synonym: "isoprenoid-alcohol kinase activity" BROAD [EC:2.7.1.66] synonym: "polyisoprenol kinase activity" EXACT [EC:2.7.1.66] xref: EC:2.7.1.66 xref: MetaCyc:UNDECAPRENOL-KINASE-RXN is_a: GO:0016301 ! kinase activity is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor [Term] id: GO:0009039 name: urease activity namespace: molecular_function def: "Catalysis of the reaction: urea + H2O = CO2 + 2 NH3." [EC:3.5.1.5] subset: gosubset_prok synonym: "urea amidohydrolase activity" EXACT [EC:3.5.1.5] xref: EC:3.5.1.5 xref: MetaCyc:UREASE-RXN xref: UM-BBD_enzymeID:e0170 is_a: GO:0016811 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides [Term] id: GO:0009040 name: ureidoglycolate dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: (S)-ureidoglycolate + NADP+ = oxalureate + NADPH + H+." [EC:1.1.1.154] subset: gosubset_prok synonym: "(S)-ureidoglycolate:NAD(P)+ oxidoreductase activity" EXACT [EC:1.1.1.154] xref: EC:1.1.1.154 xref: MetaCyc:R165-RXN is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0009041 name: uridylate kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + (d)UMP = ADP + (d)UDP." [GOC:go_curators] subset: gosubset_prok xref: EC:2.7.4.- is_a: GO:0016776 ! phosphotransferase activity, phosphate group as acceptor is_a: GO:0019201 ! nucleotide kinase activity [Term] id: GO:0009042 name: valine-pyruvate transaminase activity namespace: molecular_function def: "Catalysis of the reaction: L-valine + pyruvate = 3-methyl-2-oxobutanoate + L-alanine." [EC:2.6.1.66] subset: gosubset_prok synonym: "alanine--valine transaminase activity" EXACT [EC:2.6.1.66] synonym: "alanine-oxoisovalerate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "L-valine:pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "transaminase C activity" NARROW [EC:2.6.1.66] synonym: "valine--pyruvate aminotransferase activity" EXACT [EC:2.6.1.66] synonym: "valine-pyruvate aminotransferase activity" EXACT [] xref: EC:2.6.1.66 xref: MetaCyc:VALINE-PYRUVATE-AMINOTRANSFER-RXN is_a: GO:0008483 ! transaminase activity [Term] id: GO:0009044 name: xylan 1,4-beta-xylosidase activity namespace: molecular_function def: "Catalysis of the hydrolysis of 1,4-beta-D-xylans so as to remove successive D-xylose residues from the non-reducing termini." [EC:3.2.1.37] subset: gosubset_prok synonym: "1,4-beta-D-xylan xylohydrolase activity" EXACT [EC:3.2.1.37] synonym: "beta-D-xylopyranosidase activity" EXACT [EC:3.2.1.37] synonym: "beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-D-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-beta-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "exo-1,4-xylosidase activity" EXACT [EC:3.2.1.37] synonym: "xylobiase activity" EXACT [EC:3.2.1.37] xref: EC:3.2.1.37 xref: MetaCyc:3.2.1.37-RXN is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0009045 name: xylose isomerase activity namespace: molecular_function def: "Catalysis of the reaction: D-xylose = D-xylulose." [EC:5.3.1.5] subset: gosubset_prok synonym: "D-xylose aldose-ketose-isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose isomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketoisomerase activity" EXACT [EC:5.3.1.5] synonym: "D-xylose ketol-isomerase activity" EXACT [EC:5.3.1.5] xref: EC:5.3.1.5 xref: MetaCyc:XYLISOM-RXN is_a: GO:0016861 ! intramolecular oxidoreductase activity, interconverting aldoses and ketoses [Term] id: GO:0009046 name: zinc D-Ala-D-Ala carboxypeptidase activity namespace: molecular_function def: "Catalysis of the cleavage of the D-alanyl-D-alanine bond in (Ac)2-L-lysyl-D-alanyl-D-alanine." [EC:3.4.17.14] synonym: "D-alanyl-D-alanine hydrolase activity" EXACT [EC:3.4.17.14] synonym: "D-alanyl-D-alanine-cleaving carboxypeptidase activity" EXACT [EC:3.4.17.14] synonym: "DD-carboxypeptidase" BROAD [EC:3.4.17.14] synonym: "DD-carboxypeptidase-transpeptidase activity" EXACT [EC:3.4.17.14] synonym: "G enzyme" RELATED [EC:3.4.17.14] synonym: "Zn(2+) G peptidase activity" RELATED [EC:3.4.17.14] synonym: "Zn2+ G peptidase activity" EXACT [EC:3.4.17.14] xref: EC:3.4.17.14 xref: MetaCyc:3.4.17.14-RXN is_a: GO:0004181 ! metallocarboxypeptidase activity [Term] id: GO:0009047 name: dosage compensation, by hyperactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global hyperactivation of all, or most of, the genes on the X-chromosome in the heterogametic sex, leading to a two-fold increase in gene expression from this chromosome. An example of this is found in Drosophila melanogaster." [GOC:jl, ISBN:0140512888, PMID:11498577] is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009048 name: dosage compensation, by inactivation of X chromosome namespace: biological_process def: "Compensating for the two-fold variation in X-chromosome:autosome ratios between sexes by a global inactivation of all, or most of, the genes on one of the X-chromosomes in the XX sex." [GOC:jl, ISBN:0140512888, PMID:11498577] synonym: "Barr body formation" RELATED [] synonym: "chromosome inactivation" BROAD [] synonym: "X chromosome inactivation" EXACT [] xref: Wikipedia:X-inactivation is_a: GO:0007549 ! dosage compensation [Term] id: GO:0009049 name: aspartic-type signal peptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the cleavage of a signal peptide from a protein precursor by an aspartic endopeptidase mechanism." [GOC:mah] comment: This term was made obsolete because 'signal peptide' is difficult to define unambiguously, and because the term refers to gene products. subset: gosubset_prok xref: EC:3.4.23.- is_obsolete: true replaced_by: GO:0004190 [Term] id: GO:0009050 name: glycopeptide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glycopeptides, any compound in which carbohydrate is covalently attached to an oligopeptide composed of residues of L and/or D-amino acids. The term usually denotes a product of proteolytic degradation of a glycoprotein but includes glycated peptide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycopeptide breakdown" EXACT [] synonym: "glycopeptide catabolism" EXACT [] synonym: "glycopeptide degradation" EXACT [] is_a: GO:0006516 ! glycoprotein catabolic process is_a: GO:0043171 ! peptide catabolic process [Term] id: GO:0009051 name: pentose-phosphate shunt, oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which involves the oxidation of glucose 6-P and produces ribulose 5-P, reduced NADP+ and carbon dioxide (CO2)." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:OXIDATIVEPENT-PWY] subset: gosubset_prok synonym: "oxidative branch, pentose pathway" EXACT [] synonym: "oxidative pentose phosphate pathway" EXACT [] synonym: "pentose phosphate pathway, oxidative branch" EXACT [] synonym: "pentose phosphate shunt, oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, oxidative branch" EXACT [] xref: MetaCyc:OXIDATIVEPENT-PWY is_a: GO:0019321 ! pentose metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009052 name: pentose-phosphate shunt, non-oxidative branch namespace: biological_process def: "The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology", MetaCyc:NONOXIPENT-PWY] subset: gosubset_prok synonym: "pentose phosphate pathway, non-oxidative branch" EXACT [] synonym: "pentose phosphate shunt, non-oxidative branch" EXACT [] synonym: "pentose-phosphate pathway, non-oxidative branch" EXACT [] xref: MetaCyc:NONOXIPENT-PWY xref: MetaCyc:P21-PWY is_a: GO:0019321 ! pentose metabolic process relationship: part_of GO:0006098 ! pentose-phosphate shunt [Term] id: GO:0009055 name: electron carrier activity namespace: molecular_function alt_id: GO:0009053 alt_id: GO:0009054 def: "Any molecular entity that serves as an electron acceptor and electron donor in an electron transport system." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_generic subset: goslim_goa subset: goslim_pir subset: gosubset_prok synonym: "2Fe-2S electron transfer carrier" NARROW [] synonym: "3Fe-4S/4Fe-4S electron transfer carrier" NARROW [] synonym: "adrenodoxin-type ferredoxin" NARROW [] synonym: "amicyanin" NARROW [] synonym: "azurin" NARROW [] synonym: "bacterial-type ferredoxin" NARROW [] synonym: "chloroplast-type ferredoxin" NARROW [] synonym: "copper electron carrier" NARROW [] synonym: "dicluster bacterial-type ferredoxin" NARROW [] synonym: "electron acceptor activity" NARROW [] synonym: "electron carrier, chlorophyll electron transport system" RELATED [] synonym: "electron donor activity" NARROW [] synonym: "electron transfer flavoprotein" NARROW [] synonym: "electron transfer flavoprotein, group I" NARROW [] synonym: "electron transfer flavoprotein, group II" NARROW [] synonym: "electron transporter activity" EXACT [] synonym: "high-potential iron-sulfur carrier" NARROW [] synonym: "iron-sulfur electron transfer carrier" NARROW [] synonym: "monocluster bacterial-type ferredoxin" NARROW [] synonym: "mononuclear iron electron carrier" NARROW [] synonym: "polyferredoxin" NARROW [] synonym: "redox-active disulfide bond electron carrier" NARROW [] synonym: "rubredoxin" NARROW [] synonym: "small blue copper electron carrier" NARROW [] synonym: "thioredoxin-like 2Fe-2S ferredoxin" NARROW [] xref: Reactome:20046 "electron carrier activity" is_a: GO:0003674 ! molecular_function [Term] id: GO:0009056 name: catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of substances, including the breakdown of carbon compounds with the liberation of energy for use by the cell or organism." [ISBN:0198547684] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "breakdown" EXACT [] synonym: "catabolism" EXACT [] synonym: "degradation" EXACT [] xref: Wikipedia:Catabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009057 name: macromolecule catabolic process namespace: biological_process alt_id: GO:0043285 def: "The chemical reactions and pathways resulting in the breakdown of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer catabolic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule breakdown" EXACT [] synonym: "macromolecule catabolism" EXACT [] synonym: "macromolecule degradation" EXACT [] is_a: GO:0009056 ! catabolic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0009058 name: biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of substances; typically the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones." [GOC:curators, ISBN:0198547684] subset: goslim_generic subset: goslim_goa subset: goslim_plant subset: gosubset_prok synonym: "anabolism" EXACT [] synonym: "biosynthesis" EXACT [] synonym: "formation" EXACT [] synonym: "synthesis" EXACT [] xref: Wikipedia:Anabolism is_a: GO:0008152 ! metabolic process [Term] id: GO:0009059 name: macromolecule biosynthetic process namespace: biological_process alt_id: GO:0043284 def: "The chemical reactions and pathways resulting in the formation of a macromolecule, any molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass." [ChEBI:33694, GOC:mah] subset: gosubset_prok synonym: "biopolymer biosynthetic process" EXACT [GOC:mtg_chebi_dec09] synonym: "macromolecule anabolism" EXACT [] synonym: "macromolecule biosynthesis" EXACT [] synonym: "macromolecule formation" EXACT [] synonym: "macromolecule synthesis" EXACT [] is_a: GO:0009058 ! biosynthetic process is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0009060 name: aerobic respiration namespace: biological_process def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which requires oxygen as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] subset: gosubset_prok xref: MetaCyc:PWY-3781 xref: Wikipedia:Cellular_respiration#Aerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009061 name: anaerobic respiration namespace: biological_process def: "The enzymatic release of energy from organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor." [GOC:jl, ISBN:0140513590] subset: gosubset_prok xref: MetaCyc:ANARESP1-PWY xref: Wikipedia:Anaerobic_respiration xref: Wikipedia:Cellular_respiration#Anaerobic_respiration is_a: GO:0045333 ! cellular respiration [Term] id: GO:0009062 name: fatty acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes." [GOC:go_curators] subset: gosubset_prok synonym: "fatty acid breakdown" EXACT [] synonym: "fatty acid catabolism" EXACT [] synonym: "fatty acid degradation" EXACT [] xref: Wikipedia:Fatty_acid_degradation is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0009063 name: cellular amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents." [GOC:ai] subset: gosubset_prok synonym: "amino acid catabolic process" EXACT [GOC:curators] synonym: "cellular amino acid breakdown" EXACT [] synonym: "cellular amino acid catabolism" EXACT [] synonym: "cellular amino acid degradation" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0009310 ! amine catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process [Term] id: GO:0009064 name: glutamine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009065 name: glutamine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid breakdown" EXACT [] synonym: "glutamine family amino acid catabolism" EXACT [] synonym: "glutamine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0009066 name: aspartate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009067 name: aspartate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid anabolism" EXACT [] synonym: "aspartate family amino acid biosynthesis" EXACT [] synonym: "aspartate family amino acid formation" EXACT [] synonym: "aspartate family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0009068 name: aspartate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the aspartate family, comprising asparagine, aspartate, lysine, methionine and threonine." [GOC:ai] subset: gosubset_prok synonym: "aspartate family amino acid breakdown" EXACT [] synonym: "aspartate family amino acid catabolism" EXACT [] synonym: "aspartate family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009066 ! aspartate family amino acid metabolic process [Term] id: GO:0009069 name: serine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009070 name: serine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid anabolism" EXACT [] synonym: "serine family amino acid biosynthesis" EXACT [] synonym: "serine family amino acid formation" EXACT [] synonym: "serine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009071 name: serine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the serine family, comprising cysteine, glycine, homoserine, selenocysteine and serine." [GOC:ai] subset: gosubset_prok synonym: "serine family amino acid breakdown" EXACT [] synonym: "serine family amino acid catabolism" EXACT [] synonym: "serine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009072 name: aromatic amino acid family metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process [Term] id: GO:0009073 name: aromatic amino acid family biosynthetic process namespace: biological_process alt_id: GO:0016089 def: "The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family anabolism" EXACT [] synonym: "aromatic amino acid family biosynthesis" EXACT [] synonym: "aromatic amino acid family biosynthetic process, shikimate pathway" RELATED [] synonym: "aromatic amino acid family formation" EXACT [] synonym: "aromatic amino acid family synthesis" EXACT [] xref: MetaCyc:COMPLETE-ARO-PWY is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009074 name: aromatic amino acid family catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan)." [GOC:go_curators] subset: gosubset_prok synonym: "aromatic amino acid family breakdown" EXACT [] synonym: "aromatic amino acid family catabolism" EXACT [] synonym: "aromatic amino acid family degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009072 ! aromatic amino acid family metabolic process is_a: GO:0019439 ! aromatic compound catabolic process [Term] id: GO:0009075 name: histidine family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009076 name: histidine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid anabolism" EXACT [] synonym: "histidine family amino acid biosynthesis" EXACT [] synonym: "histidine family amino acid formation" EXACT [] synonym: "histidine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009075 ! histidine family amino acid metabolic process [Term] id: GO:0009077 name: histidine family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids of the histidine family." [GOC:ai] subset: gosubset_prok synonym: "histidine family amino acid breakdown" EXACT [] synonym: "histidine family amino acid catabolism" EXACT [] synonym: "histidine family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009075 ! histidine family amino acid metabolic process [Term] id: GO:0009078 name: pyruvate family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009079 name: pyruvate family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid anabolism" EXACT [] synonym: "pyruvate family amino acid biosynthesis" EXACT [] synonym: "pyruvate family amino acid formation" EXACT [] synonym: "pyruvate family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0009080 name: pyruvate family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any amino acid that requires pyruvate for its synthesis, e.g. alanine." [GOC:jl] subset: gosubset_prok synonym: "pyruvate family amino acid breakdown" EXACT [] synonym: "pyruvate family amino acid catabolism" EXACT [] synonym: "pyruvate family amino acid degradation" EXACT [] is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009078 ! pyruvate family amino acid metabolic process [Term] id: GO:0009081 name: branched chain family amino acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid metabolism" EXACT [] is_a: GO:0006520 ! cellular amino acid metabolic process [Term] id: GO:0009082 name: branched chain family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid anabolism" EXACT [] synonym: "branched chain family amino acid biosynthesis" EXACT [] synonym: "branched chain family amino acid formation" EXACT [] synonym: "branched chain family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0009083 name: branched chain family amino acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine." [GOC:ai] subset: gosubset_prok synonym: "branched chain family amino acid breakdown" EXACT [] synonym: "branched chain family amino acid catabolism" EXACT [] synonym: "branched chain family amino acid degradation" EXACT [] xref: Reactome:562642 "Branched-chain amino acid catabolism" xref: Reactome:588267 "Branched-chain amino acid catabolism" xref: Reactome:609021 "Branched-chain amino acid catabolism" xref: Reactome:633711 "Branched-chain amino acid catabolism" xref: Reactome:645325 "Branched-chain amino acid catabolism" xref: Reactome:655699 "Branched-chain amino acid catabolism" xref: Reactome:660970 "Branched-chain amino acid catabolism" xref: Reactome:666745 "Branched-chain amino acid catabolism" xref: Reactome:672850 "Branched-chain amino acid catabolism" xref: Reactome:678570 "Branched-chain amino acid catabolism" xref: Reactome:683530 "Branched-chain amino acid catabolism" xref: Reactome:689732 "Branched-chain amino acid catabolism" xref: Reactome:701463 "Branched-chain amino acid catabolism" xref: Reactome:70895 "Branched-chain amino acid catabolism" xref: Reactome:716034 "Branched-chain amino acid catabolism" xref: Reactome:727984 "Branched-chain amino acid catabolism" xref: Reactome:730919 "Branched-chain amino acid catabolism" xref: Reactome:733047 "Branched-chain amino acid catabolism" xref: Reactome:733859 "Branched-chain amino acid catabolism" xref: Reactome:735581 "Branched-chain amino acid catabolism" xref: Reactome:736540 "Branched-chain amino acid catabolism" xref: Reactome:738492 "Branched-chain amino acid catabolism" is_a: GO:0009063 ! cellular amino acid catabolic process is_a: GO:0009081 ! branched chain family amino acid metabolic process [Term] id: GO:0009084 name: glutamine family amino acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline." [GOC:ai] subset: gosubset_prok synonym: "glutamine family amino acid anabolism" EXACT [] synonym: "glutamine family amino acid biosynthesis" EXACT [] synonym: "glutamine family amino acid formation" EXACT [] synonym: "glutamine family amino acid synthesis" EXACT [] is_a: GO:0008652 ! cellular amino acid biosynthetic process is_a: GO:0009064 ! glutamine family amino acid metabolic process [Term] id: GO:0009085 name: lysine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, 2,6-diaminohexanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "lysine anabolism" EXACT [] synonym: "lysine biosynthesis" EXACT [] synonym: "lysine formation" EXACT [] synonym: "lysine synthesis" EXACT [] xref: MetaCyc:PWY-5097 is_a: GO:0006553 ! lysine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009086 name: methionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine anabolism" EXACT [] synonym: "methionine biosynthesis" EXACT [] synonym: "methionine formation" EXACT [] synonym: "methionine synthesis" EXACT [] is_a: GO:0000097 ! sulfur amino acid biosynthetic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009087 name: methionine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "methionine breakdown" EXACT [] synonym: "methionine catabolism" EXACT [] synonym: "methionine degradation" EXACT [] xref: UM-BBD_pathwayID:met is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009068 ! aspartate family amino acid catabolic process [Term] id: GO:0009088 name: threonine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "threonine anabolism" EXACT [] synonym: "threonine biosynthesis" EXACT [] synonym: "threonine formation" EXACT [] synonym: "threonine synthesis" EXACT [] xref: MetaCyc:HOMOSER-THRESYN-PWY xref: MetaCyc:THRESYN-PWY is_a: GO:0006566 ! threonine metabolic process is_a: GO:0009067 ! aspartate family amino acid biosynthetic process [Term] id: GO:0009089 name: lysine biosynthetic process via diaminopimelate namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate." [GOC:go_curators] subset: gosubset_prok synonym: "diaminopimelate pathway" EXACT [] synonym: "diaminopimelic acid pathway" EXACT [] synonym: "lysine anabolism via diaminopimelate" EXACT [] synonym: "lysine biosynthesis via diaminopimelic acid" EXACT [] synonym: "lysine biosynthetic process via diaminopimelic acid" EXACT [] synonym: "lysine formation via diaminopimelate" EXACT [] synonym: "lysine synthesis via diaminopimelate" EXACT [] is_a: GO:0009085 ! lysine biosynthetic process is_a: GO:0046451 ! diaminopimelate metabolic process [Term] id: GO:0009090 name: homoserine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine anabolism" EXACT [] synonym: "homoserine biosynthesis" EXACT [] synonym: "homoserine formation" EXACT [] synonym: "homoserine synthesis" EXACT [] xref: MetaCyc:HOMOSERSYN-PWY is_a: GO:0009070 ! serine family amino acid biosynthetic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009091 name: homoserine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of homoserine, alpha-amino-gamma-hydroxybutyric acid." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine breakdown" EXACT [] synonym: "homoserine catabolism" EXACT [] synonym: "homoserine degradation" EXACT [] xref: MetaCyc:HOMOCYSDEGR-PWY is_a: GO:0009071 ! serine family amino acid catabolic process is_a: GO:0009092 ! homoserine metabolic process [Term] id: GO:0009092 name: homoserine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homoserine, alpha-amino-gamma-hydroxybutyric acid, an intermediate in the biosynthesis of cystathionine, threonine and methionine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "homoserine metabolism" EXACT [] is_a: GO:0009069 ! serine family amino acid metabolic process [Term] id: GO:0009093 name: cysteine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cysteine, 2-amino-3-mercaptopropanoic acid." [GOC:go_curators] subset: gosubset_prok synonym: "cysteine breakdown" EXACT [] synonym: "cysteine catabolism" EXACT [] synonym: "cysteine degradation" EXACT [] xref: Wikipedia:Cysteine is_a: GO:0000098 ! sulfur amino acid catabolic process is_a: GO:0006534 ! cysteine metabolic process is_a: GO:0009071 ! serine family amino acid catabolic process [Term] id: GO:0009094 name: L-phenylalanine biosynthetic process namespace: biological_process alt_id: GO:0019274 alt_id: GO:0019275 def: "The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid." [ChEBI:17295, GOC:go_curators, GOC:jsg, GOC:mah] subset: gosubset_prok synonym: "L-phenylalanine anabolism" EXACT [] synonym: "L-phenylalanine biosynthesis" EXACT [] synonym: "L-phenylalanine formation" EXACT [] synonym: "L-phenylalanine synthesis" EXACT [] synonym: "phenylalanine biosynthesis" BROAD [] synonym: "phenylalanine biosynthetic process" BROAD [] synonym: "phenylalanine biosynthetic process, prephenate pathway" RELATED [] synonym: "phenylalanine biosynthetic process, shikimate pathway" RELATED [] is_a: GO:0006558 ! L-phenylalanine metabolic process is_a: GO:0009095 ! aromatic amino acid family biosynthetic process, prephenate pathway [Term] id: GO:0009095 name: aromatic amino acid family biosynthetic process, prephenate pathway namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phenylalanine and tyrosine from other compounds, including chorismate, via the intermediate prephenate." [GOC:mah, ISBN:0471331309 "Biochemical Pathways"] subset: gosubset_prok synonym: "aromatic amino acid family anabolism, prephenate pathway" EXACT [] synonym: "aromatic amino acid family formation, prephenate pathway" EXACT [] synonym: "aromatic amino acid family synthesis, prephenate pathway" EXACT [] is_a: GO:0009073 ! aromatic amino acid family biosynthetic process [Term] id: GO:0009097 name: isoleucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoleucine, (2R*,3R*)-2-amino-3-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "isoleucine anabolism" EXACT [] synonym: "isoleucine biosynthesis" EXACT [] synonym: "isoleucine formation" EXACT [] synonym: "isoleucine synthesis" EXACT [] xref: MetaCyc:ILEUSYN-PWY is_a: GO:0006549 ! isoleucine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009098 name: leucine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of leucine, 2-amino-4-methylpentanoic acid." [GOC:ai] subset: gosubset_prok synonym: "leucine anabolism" EXACT [] synonym: "leucine biosynthesis" EXACT [] synonym: "leucine formation" EXACT [] synonym: "leucine synthesis" EXACT [] xref: MetaCyc:LEUSYN-PWY is_a: GO:0006551 ! leucine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009099 name: valine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of valine, 2-amino-3-methylbutanoic acid." [GOC:ai] subset: gosubset_prok synonym: "valine anabolism" EXACT [] synonym: "valine biosynthesis" EXACT [] synonym: "valine formation" EXACT [] synonym: "valine synthesis" EXACT [] xref: MetaCyc:VALSYN-PWY is_a: GO:0006573 ! valine metabolic process is_a: GO:0009082 ! branched chain family amino acid biosynthetic process [Term] id: GO:0009100 name: glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein metabolism" EXACT [] is_a: GO:0044260 ! cellular macromolecule metabolic process [Term] id: GO:0009101 name: glycoprotein biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycoproteins, any protein that contains covalently bound glycose (i.e. monosaccharide) residues other than as a moiety of nucleic acid; the glycose occurs most commonly as oligosaccharide or fairly small polysaccharide but occasionally as monosaccharide." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycoprotein anabolism" EXACT [] synonym: "glycoprotein biosynthesis" EXACT [] synonym: "glycoprotein formation" EXACT [] synonym: "glycoprotein synthesis" EXACT [] xref: Reactome:162699 "Synthesis of dolichol-phosphate mannose" xref: Reactome:673115 "Synthesis of dolichol-phosphate mannose" xref: Reactome:701736 "Synthesis of dolichol-phosphate mannose" xref: Reactome:728260 "Synthesis of dolichol-phosphate mannose" is_a: GO:0009100 ! glycoprotein metabolic process is_a: GO:0034645 ! cellular macromolecule biosynthetic process [Term] id: GO:0009102 name: biotin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "biotin anabolism" EXACT [] synonym: "biotin biosynthesis" EXACT [] synonym: "biotin formation" EXACT [] synonym: "biotin synthesis" EXACT [] synonym: "vitamin B7 biosynthesis" EXACT [] synonym: "vitamin B7 biosynthetic process" EXACT [] synonym: "vitamin H biosynthesis" EXACT [] synonym: "vitamin H biosynthetic process" EXACT [] xref: MetaCyc:BIOTIN-SYNTHESIS-PWY is_a: GO:0006768 ! biotin metabolic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0043604 ! amide biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009103 name: lipopolysaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] subset: gosubset_prok synonym: "lipopolysaccharide anabolism" EXACT [] synonym: "lipopolysaccharide biosynthesis" EXACT [] synonym: "lipopolysaccharide formation" EXACT [] synonym: "lipopolysaccharide synthesis" EXACT [] synonym: "LPS biosynthetic process" EXACT [] is_a: GO:0008610 ! lipid biosynthetic process is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009104 name: lipopolysaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria." [GOC:ai] subset: gosubset_prok synonym: "lipopolysaccharide breakdown" EXACT [] synonym: "lipopolysaccharide catabolism" EXACT [] synonym: "lipopolysaccharide degradation" EXACT [] synonym: "LPS catabolic process" EXACT [] is_a: GO:0008653 ! lipopolysaccharide metabolic process is_a: GO:0044242 ! cellular lipid catabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0009105 name: lipoic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoic acid, 1,2-dithiolane-3-pentanoic acid, a coenzyme involved in oxidative decarboxylation of keto acids." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "lipoic acid anabolism" EXACT [] synonym: "lipoic acid biosynthesis" EXACT [] synonym: "lipoic acid formation" EXACT [] synonym: "lipoic acid synthesis" EXACT [] is_a: GO:0000273 ! lipoic acid metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009106 name: lipoate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoate metabolism" EXACT [] is_a: GO:0000273 ! lipoic acid metabolic process [Term] id: GO:0009107 name: lipoate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipoate, 1,2-dithiolane-3-pentanoate, the anion derived from lipoic acid." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipoate anabolism" EXACT [] synonym: "lipoate biosynthesis" EXACT [] synonym: "lipoate formation" EXACT [] synonym: "lipoate synthesis" EXACT [] is_a: GO:0009105 ! lipoic acid biosynthetic process is_a: GO:0009106 ! lipoate metabolic process [Term] id: GO:0009108 name: coenzyme biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] subset: gosubset_prok synonym: "coenzyme anabolism" EXACT [] synonym: "coenzyme and prosthetic group biosynthesis" BROAD [] synonym: "coenzyme and prosthetic group biosynthetic process" BROAD [] synonym: "coenzyme biosynthesis" EXACT [] synonym: "coenzyme formation" EXACT [] synonym: "coenzyme synthesis" EXACT [] xref: Reactome:196783 "Coenzyme A biosynthesis" xref: Reactome:562832 "Coenzyme A biosynthesis" xref: Reactome:588448 "Coenzyme A biosynthesis" xref: Reactome:609410 "Coenzyme A biosynthesis" xref: Reactome:633884 "Coenzyme A biosynthesis" xref: Reactome:645467 "Coenzyme A biosynthesis" xref: Reactome:655830 "Coenzyme A biosynthesis" xref: Reactome:661018 "Coenzyme A biosynthesis" xref: Reactome:666800 "Coenzyme A biosynthesis" xref: Reactome:672911 "Coenzyme A biosynthesis" xref: Reactome:678625 "Coenzyme A biosynthesis" xref: Reactome:683565 "Coenzyme A biosynthesis" xref: Reactome:689795 "Coenzyme A biosynthesis" xref: Reactome:701506 "Coenzyme A biosynthesis" xref: Reactome:716092 "Coenzyme A biosynthesis" xref: Reactome:720701 "Coenzyme A biosynthesis" xref: Reactome:728059 "Coenzyme A biosynthesis" xref: Reactome:731034 "Coenzyme A biosynthesis" xref: Reactome:733133 "Coenzyme A biosynthesis" xref: Reactome:733878 "Coenzyme A biosynthesis" xref: Reactome:735679 "Coenzyme A biosynthesis" xref: Reactome:736625 "Coenzyme A biosynthesis" xref: Reactome:738613 "Coenzyme A biosynthesis" is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051188 ! cofactor biosynthetic process [Term] id: GO:0009109 name: coenzyme catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of coenzymes, any of various nonprotein organic cofactors that are required, in addition to an enzyme and a substrate, for an enzymatic reaction to proceed." [GOC:ai] subset: gosubset_prok synonym: "coenzyme and prosthetic group catabolic process" BROAD [] synonym: "coenzyme and prosthetic group catabolism" BROAD [] synonym: "coenzyme breakdown" EXACT [] synonym: "coenzyme catabolism" EXACT [] synonym: "coenzyme degradation" EXACT [] is_a: GO:0006732 ! coenzyme metabolic process is_a: GO:0051187 ! cofactor catabolic process [Term] id: GO:0009110 name: vitamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin anabolism" EXACT [] synonym: "vitamin biosynthesis" EXACT [] synonym: "vitamin formation" EXACT [] synonym: "vitamin synthesis" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044249 ! cellular biosynthetic process is_a: GO:0044283 ! small molecule biosynthetic process [Term] id: GO:0009111 name: vitamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a vitamin, one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body." [GOC:ai] subset: gosubset_prok synonym: "vitamin breakdown" EXACT [] synonym: "vitamin catabolism" EXACT [] synonym: "vitamin degradation" EXACT [] is_a: GO:0006766 ! vitamin metabolic process is_a: GO:0044248 ! cellular catabolic process is_a: GO:0044282 ! small molecule catabolic process [Term] id: GO:0009112 name: nucleobase metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleobase, a nitrogenous base that is a constituent of a nucleic acid, e.g. the purines: adenine, guanine, hypoxanthine, xanthine and the pyrimidines: cytosine, uracil, thymine." [GOC:ma] subset: gosubset_prok synonym: "nucleobase metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0046483 ! heterocycle metabolic process is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0009113 name: purine base biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine bases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine base anabolism" EXACT [] synonym: "purine base biosynthesis" EXACT [] synonym: "purine base formation" EXACT [] synonym: "purine base synthesis" EXACT [] xref: MetaCyc:PWY-841 is_a: GO:0006144 ! purine base metabolic process is_a: GO:0046112 ! nucleobase biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process [Term] id: GO:0009114 name: hypoxanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of hypoxanthine, 6-hydroxy purine, an intermediate in the degradation of adenylate. Its ribonucleoside is known as inosine and its ribonucleotide as inosinate." [GOC:go_curators] subset: gosubset_prok synonym: "hypoxanthine breakdown" EXACT [] synonym: "hypoxanthine catabolism" EXACT [] synonym: "hypoxanthine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046100 ! hypoxanthine metabolic process [Term] id: GO:0009115 name: xanthine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of xanthine, 2,6-dihydroxypurine, a purine formed in the metabolic breakdown of guanine but not present in nucleic acids." [GOC:go_curators] subset: gosubset_prok synonym: "xanthine breakdown" EXACT [] synonym: "xanthine catabolism" EXACT [] synonym: "xanthine degradation" EXACT [] is_a: GO:0006145 ! purine base catabolic process is_a: GO:0046110 ! xanthine metabolic process [Term] id: GO:0009116 name: nucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine)." [GOC:ma] subset: goslim_pir subset: gosubset_prok synonym: "nucleoside metabolism" EXACT [] is_a: GO:0055086 ! nucleobase, nucleoside and nucleotide metabolic process [Term] id: GO:0009117 name: nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleotide, a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic nucleotides (nucleoside cyclic phosphates)." [GOC:ma] subset: goslim_pir subset: gosubset_prok synonym: "nucleotide metabolism" EXACT [] is_a: GO:0006753 ! nucleoside phosphate metabolic process [Term] id: GO:0009118 name: regulation of nucleoside metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving nucleosides." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of nucleoside metabolism" EXACT [] is_a: GO:0019219 ! regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009116 ! nucleoside metabolic process relationship: regulates GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009119 name: ribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any ribonucleoside, a nucleoside in which purine or pyrimidine base is linked to a ribose (beta-D-ribofuranose) molecule." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "ribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009120 name: deoxyribonucleoside metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "deoxyribonucleoside metabolism" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process [Term] id: GO:0009123 name: nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009124 name: nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate anabolism" EXACT [] synonym: "nucleoside monophosphate biosynthesis" EXACT [] synonym: "nucleoside monophosphate formation" EXACT [] synonym: "nucleoside monophosphate synthesis" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009125 name: nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside monophosphate breakdown" EXACT [] synonym: "nucleoside monophosphate catabolism" EXACT [] synonym: "nucleoside monophosphate degradation" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009126 name: purine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009127 name: purine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate anabolism" EXACT [] synonym: "purine nucleoside monophosphate biosynthesis" EXACT [] synonym: "purine nucleoside monophosphate formation" EXACT [] synonym: "purine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009128 name: purine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside monophosphate breakdown" EXACT [] synonym: "purine nucleoside monophosphate catabolism" EXACT [] synonym: "purine nucleoside monophosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process [Term] id: GO:0009129 name: pyrimidine nucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009130 name: pyrimidine nucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside monophosphate formation" EXACT [] synonym: "pyrimidine nucleoside monophosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009131 name: pyrimidine nucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside monophosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process [Term] id: GO:0009132 name: nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009133 name: nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate anabolism" EXACT [] synonym: "nucleoside diphosphate biosynthesis" EXACT [] synonym: "nucleoside diphosphate formation" EXACT [] synonym: "nucleoside diphosphate synthesis" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009134 name: nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside diphosphate breakdown" EXACT [] synonym: "nucleoside diphosphate catabolism" EXACT [] synonym: "nucleoside diphosphate degradation" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009135 name: purine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009136 name: purine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate anabolism" EXACT [] synonym: "purine nucleoside diphosphate biosynthesis" EXACT [] synonym: "purine nucleoside diphosphate formation" EXACT [] synonym: "purine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009137 name: purine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside diphosphate breakdown" EXACT [] synonym: "purine nucleoside diphosphate catabolism" EXACT [] synonym: "purine nucleoside diphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process [Term] id: GO:0009138 name: pyrimidine nucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009132 ! nucleoside diphosphate metabolic process [Term] id: GO:0009139 name: pyrimidine nucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside diphosphate formation" EXACT [] synonym: "pyrimidine nucleoside diphosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009140 name: pyrimidine nucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside diphosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process [Term] id: GO:0009141 name: nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009142 name: nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate anabolism" EXACT [] synonym: "nucleoside triphosphate biosynthesis" EXACT [] synonym: "nucleoside triphosphate formation" EXACT [] synonym: "nucleoside triphosphate synthesis" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009165 ! nucleotide biosynthetic process [Term] id: GO:0009143 name: nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a nucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose or ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleoside triphosphate breakdown" EXACT [] synonym: "nucleoside triphosphate catabolism" EXACT [] synonym: "nucleoside triphosphate degradation" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009166 ! nucleotide catabolic process [Term] id: GO:0009144 name: purine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009145 name: purine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate anabolism" EXACT [] synonym: "purine nucleoside triphosphate biosynthesis" EXACT [] synonym: "purine nucleoside triphosphate formation" EXACT [] synonym: "purine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009146 name: purine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine nucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine nucleoside triphosphate breakdown" EXACT [] synonym: "purine nucleoside triphosphate catabolism" EXACT [] synonym: "purine nucleoside triphosphate degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process [Term] id: GO:0009147 name: pyrimidine nucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009141 ! nucleoside triphosphate metabolic process [Term] id: GO:0009148 name: pyrimidine nucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine nucleoside triphosphate formation" EXACT [] synonym: "pyrimidine nucleoside triphosphate synthesis" EXACT [] is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009149 name: pyrimidine nucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine nucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose or deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine nucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine nucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine nucleoside triphosphate degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process [Term] id: GO:0009150 name: purine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009151 name: purine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006163 ! purine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009152 name: purine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide anabolism" EXACT [] synonym: "purine ribonucleotide biosynthesis" EXACT [] synonym: "purine ribonucleotide formation" EXACT [] synonym: "purine ribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009153 name: purine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide anabolism" EXACT [] synonym: "purine deoxyribonucleotide biosynthesis" EXACT [] synonym: "purine deoxyribonucleotide formation" EXACT [] synonym: "purine deoxyribonucleotide synthesis" EXACT [] is_a: GO:0006164 ! purine nucleotide biosynthetic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009154 name: purine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleotide breakdown" EXACT [] synonym: "purine ribonucleotide catabolism" EXACT [] synonym: "purine ribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009155 name: purine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a purine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleotide breakdown" EXACT [] synonym: "purine deoxyribonucleotide catabolism" EXACT [] synonym: "purine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006195 ! purine nucleotide catabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009156 name: ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate anabolism" EXACT [] synonym: "ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "ribonucleoside monophosphate formation" EXACT [] synonym: "ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009157 name: deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside monophosphate formation" EXACT [] synonym: "deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009158 name: ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate breakdown" EXACT [] synonym: "ribonucleoside monophosphate catabolism" EXACT [] synonym: "ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009159 name: deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009161 name: ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside monophosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009162 name: deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside monophosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009163 name: nucleoside biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "nucleoside anabolism" EXACT [] synonym: "nucleoside biosynthesis" EXACT [] synonym: "nucleoside formation" EXACT [] synonym: "nucleoside synthesis" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process [Term] id: GO:0009164 name: nucleoside catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside)." [GOC:jl] subset: gosubset_prok synonym: "nucleoside breakdown" EXACT [] synonym: "nucleoside catabolism" EXACT [] synonym: "nucleoside degradation" EXACT [] is_a: GO:0009116 ! nucleoside metabolic process is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0009165 name: nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] subset: gosubset_prok synonym: "nucleotide anabolism" EXACT [] synonym: "nucleotide biosynthesis" EXACT [] synonym: "nucleotide formation" EXACT [] synonym: "nucleotide synthesis" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0034404 ! nucleobase, nucleoside and nucleotide biosynthetic process [Term] id: GO:0009166 name: nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates)." [GOC:go_curators] subset: gosubset_prok synonym: "nucleotide breakdown" EXACT [] synonym: "nucleotide catabolism" EXACT [] synonym: "nucleotide degradation" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process is_a: GO:0034656 ! nucleobase, nucleoside and nucleotide catabolic process [Term] id: GO:0009167 name: purine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process [Term] id: GO:0009168 name: purine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate anabolism" EXACT [] synonym: "purine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside monophosphate formation" EXACT [] synonym: "purine ribonucleoside monophosphate synthesis" EXACT [] xref: Reactome:562632 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:588258 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:609015 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:633705 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:645320 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:655693 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:660967 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:666741 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:672846 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:678568 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:683525 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:689727 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:701458 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:716029 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:727979 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:731129 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:733018 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:733856 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:735578 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:736537 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:73817 "Purine ribonucleoside monophosphate biosynthesis" xref: Reactome:738488 "Purine ribonucleoside monophosphate biosynthesis" is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009169 name: purine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside monophosphate breakdown" EXACT [] synonym: "purine ribonucleoside monophosphate catabolism" EXACT [] synonym: "purine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009167 ! purine ribonucleoside monophosphate metabolic process [Term] id: GO:0009170 name: purine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009126 ! purine nucleoside monophosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009171 name: purine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "purine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009127 ! purine nucleoside monophosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009172 name: purine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside monophosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009128 ! purine nucleoside monophosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009170 ! purine deoxyribonucleoside monophosphate metabolic process [Term] id: GO:0009173 name: pyrimidine ribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009161 ! ribonucleoside monophosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009174 name: pyrimidine ribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009175 name: pyrimidine ribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009158 ! ribonucleoside monophosphate catabolic process is_a: GO:0009173 ! pyrimidine ribonucleoside monophosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009176 name: pyrimidine deoxyribonucleoside monophosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate metabolism" EXACT [] is_a: GO:0009129 ! pyrimidine nucleoside monophosphate metabolic process is_a: GO:0009162 ! deoxyribonucleoside monophosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0009177 name: pyrimidine deoxyribonucleoside monophosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate synthesis" EXACT [] is_a: GO:0009130 ! pyrimidine nucleoside monophosphate biosynthetic process is_a: GO:0009157 ! deoxyribonucleoside monophosphate biosynthetic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009178 name: pyrimidine deoxyribonucleoside monophosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside monophosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with phosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside monophosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside monophosphate degradation" EXACT [] is_a: GO:0009131 ! pyrimidine nucleoside monophosphate catabolic process is_a: GO:0009159 ! deoxyribonucleoside monophosphate catabolic process is_a: GO:0009176 ! pyrimidine deoxyribonucleoside monophosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009179 name: purine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process [Term] id: GO:0009180 name: purine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate anabolism" EXACT [] synonym: "purine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside diphosphate formation" EXACT [] synonym: "purine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process [Term] id: GO:0009181 name: purine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside diphosphate breakdown" EXACT [] synonym: "purine ribonucleoside diphosphate catabolism" EXACT [] synonym: "purine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009179 ! purine ribonucleoside diphosphate metabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process [Term] id: GO:0009182 name: purine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009135 ! purine nucleoside diphosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process [Term] id: GO:0009183 name: purine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009136 ! purine nucleoside diphosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process [Term] id: GO:0009184 name: purine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside diphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009137 ! purine nucleoside diphosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009182 ! purine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process [Term] id: GO:0009185 name: ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009186 name: deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009132 ! nucleoside diphosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009187 name: cyclic nucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide metabolism" EXACT [] is_a: GO:0009123 ! nucleoside monophosphate metabolic process [Term] id: GO:0009188 name: ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate anabolism" EXACT [] synonym: "ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "ribonucleoside diphosphate formation" EXACT [] synonym: "ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009189 name: deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside diphosphate formation" EXACT [] synonym: "deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009133 ! nucleoside diphosphate biosynthetic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009190 name: cyclic nucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide anabolism" EXACT [] synonym: "cyclic nucleotide biosynthesis" EXACT [] synonym: "cyclic nucleotide formation" EXACT [] synonym: "cyclic nucleotide synthesis" EXACT [] is_a: GO:0009124 ! nucleoside monophosphate biosynthetic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009191 name: ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside diphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside diphosphate breakdown" EXACT [] synonym: "ribonucleoside diphosphate catabolism" EXACT [] synonym: "ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009192 name: deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside diphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009134 ! nucleoside diphosphate catabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009193 name: pyrimidine ribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009185 ! ribonucleoside diphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009194 name: pyrimidine ribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009188 ! ribonucleoside diphosphate biosynthetic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009195 name: pyrimidine ribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009191 ! ribonucleoside diphosphate catabolic process is_a: GO:0009193 ! pyrimidine ribonucleoside diphosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009196 name: pyrimidine deoxyribonucleoside diphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate metabolism" EXACT [] is_a: GO:0009138 ! pyrimidine nucleoside diphosphate metabolic process is_a: GO:0009186 ! deoxyribonucleoside diphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process [Term] id: GO:0009197 name: pyrimidine deoxyribonucleoside diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate synthesis" EXACT [] is_a: GO:0009139 ! pyrimidine nucleoside diphosphate biosynthetic process is_a: GO:0009189 ! deoxyribonucleoside diphosphate biosynthetic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009198 name: pyrimidine deoxyribonucleoside diphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxynucleoside diphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with diphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside diphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside diphosphate degradation" EXACT [] is_a: GO:0009140 ! pyrimidine nucleoside diphosphate catabolic process is_a: GO:0009192 ! deoxyribonucleoside diphosphate catabolic process is_a: GO:0009196 ! pyrimidine deoxyribonucleoside diphosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009199 name: ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009200 name: deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009141 ! nucleoside triphosphate metabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009201 name: ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate anabolism" EXACT [] synonym: "ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "ribonucleoside triphosphate formation" EXACT [] synonym: "ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009202 name: deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "deoxyribonucleoside triphosphate formation" EXACT [] synonym: "deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009142 ! nucleoside triphosphate biosynthetic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process [Term] id: GO:0009203 name: ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleoside triphosphate, a glycosamine consisting of a base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleoside triphosphate breakdown" EXACT [] synonym: "ribonucleoside triphosphate catabolism" EXACT [] synonym: "ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009204 name: deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleoside triphosphate, a glycosamine consisting of a base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009143 ! nucleoside triphosphate catabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009205 name: purine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009150 ! purine ribonucleotide metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process [Term] id: GO:0009206 name: purine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate anabolism" EXACT [] synonym: "purine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine ribonucleoside triphosphate formation" EXACT [] synonym: "purine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009152 ! purine ribonucleotide biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009207 name: purine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine ribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine ribonucleoside triphosphate breakdown" EXACT [] synonym: "purine ribonucleoside triphosphate catabolism" EXACT [] synonym: "purine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009154 ! purine ribonucleotide catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009205 ! purine ribonucleoside triphosphate metabolic process [Term] id: GO:0009208 name: pyrimidine ribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009199 ! ribonucleoside triphosphate metabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process [Term] id: GO:0009209 name: pyrimidine ribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009201 ! ribonucleoside triphosphate biosynthetic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process [Term] id: GO:0009210 name: pyrimidine ribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine ribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a ribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine ribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009203 ! ribonucleoside triphosphate catabolic process is_a: GO:0009208 ! pyrimidine ribonucleoside triphosphate metabolic process is_a: GO:0009222 ! pyrimidine ribonucleotide catabolic process [Term] id: GO:0009211 name: pyrimidine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009147 ! pyrimidine nucleoside triphosphate metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0046125 ! pyrimidine deoxyribonucleoside metabolic process [Term] id: GO:0009212 name: pyrimidine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009148 ! pyrimidine nucleoside triphosphate biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process [Term] id: GO:0009213 name: pyrimidine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of pyrimidine deoxyribonucleoside triphosphate, a glycosamine consisting of a pyrimidine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009149 ! pyrimidine nucleoside triphosphate catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009211 ! pyrimidine deoxyribonucleoside triphosphate metabolic process is_a: GO:0009223 ! pyrimidine deoxyribonucleotide catabolic process [Term] id: GO:0009214 name: cyclic nucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a cyclic nucleotide, a nucleotide in which the phosphate group is in diester linkage to two positions on the sugar residue." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyclic nucleotide breakdown" EXACT [] synonym: "cyclic nucleotide catabolism" EXACT [] synonym: "cyclic nucleotide degradation" EXACT [] is_a: GO:0009125 ! nucleoside monophosphate catabolic process is_a: GO:0009187 ! cyclic nucleotide metabolic process [Term] id: GO:0009215 name: purine deoxyribonucleoside triphosphate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate metabolism" EXACT [] is_a: GO:0009144 ! purine nucleoside triphosphate metabolic process is_a: GO:0009151 ! purine deoxyribonucleotide metabolic process is_a: GO:0009200 ! deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009216 name: purine deoxyribonucleoside triphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate anabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate biosynthesis" EXACT [] synonym: "purine deoxyribonucleoside triphosphate formation" EXACT [] synonym: "purine deoxyribonucleoside triphosphate synthesis" EXACT [] is_a: GO:0009145 ! purine nucleoside triphosphate biosynthetic process is_a: GO:0009153 ! purine deoxyribonucleotide biosynthetic process is_a: GO:0009202 ! deoxyribonucleoside triphosphate biosynthetic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009217 name: purine deoxyribonucleoside triphosphate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine deoxyribonucleoside triphosphate, a glycosamine consisting of a purine base linked to a deoxyribose sugar esterified with triphosphate on its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "purine deoxyribonucleoside triphosphate breakdown" EXACT [] synonym: "purine deoxyribonucleoside triphosphate catabolism" EXACT [] synonym: "purine deoxyribonucleoside triphosphate degradation" EXACT [] is_a: GO:0009146 ! purine nucleoside triphosphate catabolic process is_a: GO:0009155 ! purine deoxyribonucleotide catabolic process is_a: GO:0009204 ! deoxyribonucleoside triphosphate catabolic process is_a: GO:0009215 ! purine deoxyribonucleoside triphosphate metabolic process [Term] id: GO:0009218 name: pyrimidine ribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009219 name: pyrimidine deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a pyrimidine deoxynucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide metabolism" EXACT [] is_a: GO:0006220 ! pyrimidine nucleotide metabolic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009220 name: pyrimidine ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide anabolism" EXACT [] synonym: "pyrimidine ribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine ribonucleotide formation" EXACT [] synonym: "pyrimidine ribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-162 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009260 ! ribonucleotide biosynthetic process [Term] id: GO:0009221 name: pyrimidine deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide anabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide biosynthesis" EXACT [] synonym: "pyrimidine deoxyribonucleotide formation" EXACT [] synonym: "pyrimidine deoxyribonucleotide synthesis" EXACT [] xref: MetaCyc:PWY0-166 is_a: GO:0006221 ! pyrimidine nucleotide biosynthetic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009265 ! 2'-deoxyribonucleotide biosynthetic process [Term] id: GO:0009222 name: pyrimidine ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine ribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine ribonucleotide breakdown" EXACT [] synonym: "pyrimidine ribonucleotide catabolism" EXACT [] synonym: "pyrimidine ribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009218 ! pyrimidine ribonucleotide metabolic process is_a: GO:0009261 ! ribonucleotide catabolic process [Term] id: GO:0009223 name: pyrimidine deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a pyrimidine deoxyribonucleotide, a compound consisting of nucleoside (a pyrimidine base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "pyrimidine deoxyribonucleotide breakdown" EXACT [] synonym: "pyrimidine deoxyribonucleotide catabolism" EXACT [] synonym: "pyrimidine deoxyribonucleotide degradation" EXACT [] is_a: GO:0006244 ! pyrimidine nucleotide catabolic process is_a: GO:0009219 ! pyrimidine deoxyribonucleotide metabolic process is_a: GO:0009264 ! deoxyribonucleotide catabolic process [Term] id: GO:0009224 name: CMP biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of CMP, cytidine monophosphate." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "CMP anabolism" EXACT [] synonym: "CMP biosynthesis" EXACT [] synonym: "CMP formation" EXACT [] synonym: "CMP synthesis" EXACT [] is_a: GO:0009174 ! pyrimidine ribonucleoside monophosphate biosynthetic process is_a: GO:0046035 ! CMP metabolic process [Term] id: GO:0009225 name: nucleotide-sugar metabolic process namespace: biological_process def: "The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "nucleotide-sugar metabolism" EXACT [] is_a: GO:0006139 ! nucleobase, nucleoside, nucleotide and nucleic acid metabolic process [Term] id: GO:0009226 name: nucleotide-sugar biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleotide-sugar anabolism" EXACT [] synonym: "nucleotide-sugar biosynthesis" EXACT [] synonym: "nucleotide-sugar formation" EXACT [] synonym: "nucleotide-sugar synthesis" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009227 name: nucleotide-sugar catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of nucleotide-sugars, any nucleotide in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "nucleotide-sugar breakdown" EXACT [] synonym: "nucleotide-sugar catabolism" EXACT [] synonym: "nucleotide-sugar degradation" EXACT [] is_a: GO:0009225 ! nucleotide-sugar metabolic process is_a: GO:0046434 ! organophosphate catabolic process [Term] id: GO:0009228 name: thiamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin anabolism" EXACT [] synonym: "thiamin biosynthesis" EXACT [] synonym: "thiamin formation" EXACT [] synonym: "thiamin synthesis" EXACT [] synonym: "thiamine biosynthesis" EXACT [] synonym: "thiamine biosynthetic process" EXACT [] synonym: "vitamin B1 biosynthesis" EXACT [] synonym: "vitamin B1 biosynthetic process" EXACT [] xref: MetaCyc:THISYN-PWY is_a: GO:0006772 ! thiamin metabolic process is_a: GO:0042724 ! thiamin and derivative biosynthetic process [Term] id: GO:0009229 name: thiamin diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of thiamin diphosphate, a derivative of thiamin (vitamin B1) which acts as a coenzyme in a range of processes including the Krebs cycle." [GOC:jl, ISBN:0140512713] subset: gosubset_prok synonym: "thiamin diphosphate anabolism" EXACT [] synonym: "thiamin diphosphate biosynthesis" EXACT [] synonym: "thiamin diphosphate formation" EXACT [] synonym: "thiamin diphosphate synthesis" EXACT [] synonym: "thiamin pyrophosphate biosynthesis" EXACT [] synonym: "thiamin pyrophosphate biosynthetic process" EXACT [] synonym: "thiamine diphosphate biosynthesis" EXACT [] synonym: "thiamine diphosphate biosynthetic process" EXACT [] synonym: "thiamine pyrophosphate biosynthesis" EXACT [] synonym: "thiamine pyrophosphate biosynthetic process" EXACT [] synonym: "TPP biosynthesis" EXACT [] synonym: "TPP biosynthetic process" EXACT [] is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0042357 ! thiamin diphosphate metabolic process is_a: GO:0042724 ! thiamin and derivative biosynthetic process [Term] id: GO:0009230 name: thiamin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of thiamin (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "thiamin breakdown" EXACT [] synonym: "thiamin catabolism" EXACT [] synonym: "thiamin degradation" EXACT [] synonym: "thiamine catabolic process" EXACT [] synonym: "thiamine catabolism" EXACT [] synonym: "vitamin B1 catabolic process" EXACT [] synonym: "vitamin B1 catabolism" EXACT [] is_a: GO:0006772 ! thiamin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042725 ! thiamin and derivative catabolic process [Term] id: GO:0009231 name: riboflavin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin anabolism" EXACT [] synonym: "riboflavin biosynthesis" EXACT [] synonym: "riboflavin formation" EXACT [] synonym: "riboflavin synthesis" EXACT [] synonym: "vitamin B2 biosynthesis" EXACT [] synonym: "vitamin B2 biosynthetic process" EXACT [] synonym: "vitamin G biosynthesis" EXACT [] synonym: "vitamin G biosynthetic process" EXACT [] xref: MetaCyc:RIBOSYN2-PWY xref: Wikipedia:Riboflavin is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process is_a: GO:0042727 ! riboflavin and derivative biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0009232 name: riboflavin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD)." [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html] subset: gosubset_prok synonym: "riboflavin breakdown" EXACT [] synonym: "riboflavin catabolism" EXACT [] synonym: "riboflavin degradation" EXACT [] synonym: "vitamin B2 catabolic process" EXACT [] synonym: "vitamin B2 catabolism" EXACT [] synonym: "vitamin G catabolic process" EXACT [] synonym: "vitamin G catabolism" EXACT [] is_a: GO:0006771 ! riboflavin metabolic process is_a: GO:0042365 ! water-soluble vitamin catabolic process is_a: GO:0042728 ! riboflavin and derivative catabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process is_a: GO:0046700 ! heterocycle catabolic process [Term] id: GO:0009233 name: menaquinone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any of the menaquinones, quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "menaquinone metabolism" EXACT [] synonym: "menatetrenone metabolic process" EXACT [] synonym: "menatetrenone metabolism" EXACT [] synonym: "multiprenylmenaquinone metabolic process" EXACT [] synonym: "multiprenylmenaquinone metabolism" EXACT [] synonym: "vitamin K2 metabolic process" EXACT [] synonym: "vitamin K2 metabolism" EXACT [] is_a: GO:0042373 ! vitamin K metabolic process [Term] id: GO:0009234 name: menaquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any of the menaquinones, any of the quinone-derived compounds synthesized by intestinal bacteria. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones have vitamin K activity and are known as vitamin K2." [GOC:jl, http://www.dentistry.leeds.ac.uk/biochem/thcme/vitamins.html#k] subset: gosubset_prok synonym: "menaquinone anabolism" EXACT [] synonym: "menaquinone biosynthesis" EXACT [] synonym: "menaquinone formation" EXACT [] synonym: "menaquinone synthesis" EXACT [] synonym: "menatetrenone biosynthesis" EXACT [] synonym: "menatetrenone biosynthetic process" EXACT [] synonym: "multiprenylmenaquinone biosynthesis" EXACT [] synonym: "multiprenylmenaquinone biosynthetic process" EXACT [] synonym: "vitamin K2 biosynthesis" EXACT [] synonym: "vitamin K2 biosynthetic process" EXACT [] xref: MetaCyc:MENAQUINONESYN-PWY is_a: GO:0009233 ! menaquinone metabolic process is_a: GO:0042371 ! vitamin K biosynthetic process [Term] id: GO:0009235 name: cobalamin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:go_curators] subset: gosubset_prok synonym: "cobalamin metabolism" EXACT [] synonym: "vitamin B12 metabolic process" EXACT [] synonym: "vitamin B12 metabolism" EXACT [] synonym: "vitamin B12 reduction" NARROW [] is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0006778 ! porphyrin metabolic process [Term] id: GO:0009236 name: cobalamin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cobalamin anabolism" EXACT [] synonym: "cobalamin biosynthesis" EXACT [] synonym: "cobalamin formation" EXACT [] synonym: "cobalamin synthesis" EXACT [] synonym: "vitamin B12 biosynthesis" EXACT [] synonym: "vitamin B12 biosynthetic process" EXACT [] is_a: GO:0006779 ! porphyrin biosynthetic process is_a: GO:0009235 ! cobalamin metabolic process is_a: GO:0042364 ! water-soluble vitamin biosynthetic process [Term] id: GO:0009237 name: siderophore metabolic process namespace: biological_process def: "The chemical reactions and pathways involving siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action." [ISBN:0198547684] subset: gosubset_prok synonym: "siderochrome metabolic process" NARROW [] synonym: "siderochrome metabolism" NARROW [] synonym: "siderophore metabolism" EXACT [] is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0009238 name: enterobactin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [ISBN:0198547684] subset: gosubset_prok synonym: "enterobactin metabolism" EXACT [] synonym: "enterochelin metabolic process" EXACT [] synonym: "enterochelin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009237 ! siderophore metabolic process [Term] id: GO:0009239 name: enterobactin biosynthetic process namespace: biological_process alt_id: GO:0031191 alt_id: GO:0031192 def: "The chemical reactions and pathways resulting in the formation of enterobactin, a catechol-derived siderochrome of Enterobacteria; enterobactin (N',N',N''-(2,6,10-trioxo-1,5,9-triacyclodecane-3,7,11-triyl)tris(2,3-dihydroxy)benzamide) is a self-triester of 2,3-dihydroxy-N-benzoyl-L-serine and a product of the shikimate pathway." [GOC:go_curators] subset: gosubset_prok synonym: "enterobactin anabolism" EXACT [] synonym: "enterobactin biosynthesis" EXACT [] synonym: "enterobactin biosynthetic process, peptide formation" NARROW [] synonym: "enterobactin biosynthetic process, peptide modification" NARROW [] synonym: "enterobactin formation" EXACT [] synonym: "enterobactin synthesis" EXACT [] synonym: "enterobactin synthetase" RELATED [] synonym: "enterochelin biosynthesis" EXACT [] synonym: "enterochelin biosynthetic process" EXACT [] xref: MetaCyc:ENTBACSYN-PWY is_a: GO:0009238 ! enterobactin metabolic process is_a: GO:0019540 ! siderophore biosynthetic process from catechol [Term] id: GO:0009240 name: isopentenyl diphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isopentenyl diphosphate, an isomer of dimethylallyl diphosphate and the key precursor of all isoprenoids." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "IPP biosynthesis" EXACT [] synonym: "IPP biosynthetic process" EXACT [] synonym: "isopentenyl diphosphate anabolism" EXACT [] synonym: "isopentenyl diphosphate biosynthesis" EXACT [] synonym: "isopentenyl diphosphate formation" EXACT [] synonym: "isopentenyl diphosphate synthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthesis" EXACT [] synonym: "isopentenyl pyrophosphate biosynthetic process" EXACT [] is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0046490 ! isopentenyl diphosphate metabolic process relationship: part_of GO:0008299 ! isoprenoid biosynthetic process [Term] id: GO:0009242 name: colanic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide." [GOC:ai] subset: gosubset_prok synonym: "colanic acid anabolism" EXACT [] synonym: "colanic acid biosynthesis" EXACT [] synonym: "colanic acid formation" EXACT [] synonym: "colanic acid synthesis" EXACT [] synonym: "M antigen biosynthesis" EXACT [] synonym: "M antigen biosynthetic process" EXACT [] xref: MetaCyc:COLANSYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046377 ! colanic acid metabolic process [Term] id: GO:0009243 name: O antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the O side chain of a lipopolysaccharide, which determines the antigenic specificity of the organism. It is made up of about 50 repeating units of a branched tetrasaccharide." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "O antigen anabolism" EXACT [] synonym: "O antigen biosynthesis" EXACT [] synonym: "O antigen formation" EXACT [] synonym: "O antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046402 ! O antigen metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009244 name: lipopolysaccharide core region biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the core region of bacterial lipopolysaccharides, which contains ten saccharide residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipopolysaccharide core region anabolism" EXACT [] synonym: "lipopolysaccharide core region biosynthesis" EXACT [] synonym: "lipopolysaccharide core region formation" EXACT [] synonym: "lipopolysaccharide core region synthesis" EXACT [] synonym: "LPS core region biosynthetic process" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process is_a: GO:0046401 ! lipopolysaccharide core region metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009245 name: lipid A biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid moiety of bacterial lipopolysaccharides, consisting of six fatty acyl chains linked to two glucosamine residues." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "lipid A anabolism" EXACT [] synonym: "lipid A biosynthesis" EXACT [] synonym: "lipid A formation" EXACT [] synonym: "lipid A synthesis" EXACT [] xref: MetaCyc:NAGLIPASYN-PWY is_a: GO:0008654 ! phospholipid biosynthetic process is_a: GO:0009247 ! glycolipid biosynthetic process is_a: GO:0046493 ! lipid A metabolic process relationship: part_of GO:0009103 ! lipopolysaccharide biosynthetic process [Term] id: GO:0009246 name: enterobacterial common antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria." [GOC:ma] subset: gosubset_prok synonym: "enterobacterial common antigen anabolism" EXACT [] synonym: "enterobacterial common antigen biosynthesis" EXACT [] synonym: "enterobacterial common antigen formation" EXACT [] synonym: "enterobacterial common antigen synthesis" EXACT [] xref: MetaCyc:ECASYN-PWY is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046378 ! enterobacterial common antigen metabolic process [Term] id: GO:0009247 name: glycolipid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glycolipid, a class of 1,2-di-O-acylglycerols joined at oxygen 3 by a glycosidic linkage to a carbohydrate part (usually a mono-, di- or tri-saccharide)." [CHEBI:33563, GOC:go_curators] subset: gosubset_prok synonym: "glycolipid anabolism" EXACT [] synonym: "glycolipid biosynthesis" EXACT [] synonym: "glycolipid formation" EXACT [] synonym: "glycolipid synthesis" EXACT [] xref: MetaCyc:PWY-401 is_a: GO:0006664 ! glycolipid metabolic process is_a: GO:0046467 ! membrane lipid biosynthetic process [Term] id: GO:0009248 name: K antigen biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a K antigen, a capsular polysaccharide antigen carried on the surface of bacterial capsules that masks somatic (O) antigens." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "K antigen anabolism" EXACT [] synonym: "K antigen biosynthesis" EXACT [] synonym: "K antigen formation" EXACT [] synonym: "K antigen synthesis" EXACT [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process is_a: GO:0046375 ! K antigen metabolic process [Term] id: GO:0009249 name: protein lipoylation namespace: biological_process def: "The addition of a lipoyl group to an amino acid residue in a protein." [GOC:mah] subset: gosubset_prok is_a: GO:0018065 ! protein-cofactor linkage [Term] id: GO:0009250 name: glucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] subset: gosubset_prok synonym: "glucan anabolism" EXACT [] synonym: "glucan biosynthesis" EXACT [] synonym: "glucan formation" EXACT [] synonym: "glucan synthesis" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0009251 name: glucan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glucans, polysaccharides consisting only of glucose residues." [GOC:go_curators] subset: gosubset_prok synonym: "glucan breakdown" EXACT [] synonym: "glucan catabolism" EXACT [] synonym: "glucan degradation" EXACT [] is_a: GO:0000272 ! polysaccharide catabolic process is_a: GO:0044042 ! glucan metabolic process [Term] id: GO:0009252 name: peptidoglycan biosynthetic process namespace: biological_process alt_id: GO:0009285 def: "The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein biosynthesis" EXACT [] synonym: "murein biosynthetic process" EXACT [] synonym: "peptidoglycan anabolism" EXACT [] synonym: "peptidoglycan biosynthesis" EXACT [] synonym: "peptidoglycan formation" EXACT [] synonym: "peptidoglycan synthesis" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006024 ! glycosaminoglycan biosynthetic process is_a: GO:0044038 ! cell wall macromolecule biosynthetic process relationship: part_of GO:0009273 ! peptidoglycan-based cell wall biogenesis [Term] id: GO:0009253 name: peptidoglycan catabolic process namespace: biological_process alt_id: GO:0009286 def: "The chemical reactions and pathways resulting in the breakdown of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls." [http://www.dsmz.de/species/murein.htm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "murein catabolic process" EXACT [] synonym: "murein catabolism" EXACT [] synonym: "peptidoglycan breakdown" EXACT [] synonym: "peptidoglycan catabolism" EXACT [] synonym: "peptidoglycan degradation" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process is_a: GO:0006027 ! glycosaminoglycan catabolic process [Term] id: GO:0009254 name: peptidoglycan turnover namespace: biological_process alt_id: GO:0009287 def: "The continual breakdown and regeneration of peptidoglycan required to maintain the cell wall." [GOC:jl] subset: gosubset_prok synonym: "murein turnover" EXACT [] is_a: GO:0000270 ! peptidoglycan metabolic process [Term] id: GO:0009255 name: Entner-Doudoroff pathway namespace: biological_process def: "A pathway that converts glucose to pyruvate and glyceraldehyde-3 phosphate by producing 6-phosphogluconate and then dehydrating it." [GOC:jl, http://cancerweb.ncl.ac.uk] subset: gosubset_prok xref: MetaCyc:ENTNER-DOUDOROFF-PWY is_a: GO:0044262 ! cellular carbohydrate metabolic process is_a: GO:0044281 ! small molecule metabolic process [Term] id: GO:0009256 name: 10-formyltetrahydrofolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF metabolic process" EXACT [] synonym: "10-formyl-THF metabolism" EXACT [] synonym: "10-formyltetrahydrofolate metabolism" EXACT [] is_a: GO:0046653 ! tetrahydrofolate metabolic process [Term] id: GO:0009257 name: 10-formyltetrahydrofolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF biosynthesis" EXACT [] synonym: "10-formyl-THF biosynthetic process" EXACT [] synonym: "10-formyltetrahydrofolate anabolism" EXACT [] synonym: "10-formyltetrahydrofolate biosynthesis" EXACT [] synonym: "10-formyltetrahydrofolate formation" EXACT [] synonym: "10-formyltetrahydrofolate synthesis" EXACT [] xref: MetaCyc:1CMET2-PWY xref: MetaCyc:PWY-3841 is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0046654 ! tetrahydrofolate biosynthetic process [Term] id: GO:0009258 name: 10-formyltetrahydrofolate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of 10-formyltetrahydrofolate, the formylated derivative of tetrahydrofolate." [GOC:ai] subset: gosubset_prok synonym: "10-formyl-THF catabolic process" EXACT [] synonym: "10-formyl-THF catabolism" EXACT [] synonym: "10-formyltetrahydrofolate breakdown" EXACT [] synonym: "10-formyltetrahydrofolate catabolism" EXACT [] synonym: "10-formyltetrahydrofolate degradation" EXACT [] is_a: GO:0009256 ! 10-formyltetrahydrofolate metabolic process is_a: GO:0009397 ! folic acid and derivative catabolic process is_a: GO:0042560 ! pteridine and derivative catabolic process [Term] id: GO:0009259 name: ribonucleotide metabolic process namespace: biological_process alt_id: GO:0009121 def: "The chemical reactions and pathways involving a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009260 name: ribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide anabolism" EXACT [] synonym: "ribonucleotide biosynthesis" EXACT [] synonym: "ribonucleotide formation" EXACT [] synonym: "ribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009261 name: ribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a ribonucleotide, a compound consisting of ribonucleoside (a base linked to a ribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "ribonucleotide breakdown" EXACT [] synonym: "ribonucleotide catabolism" EXACT [] synonym: "ribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009259 ! ribonucleotide metabolic process [Term] id: GO:0009262 name: deoxyribonucleotide metabolic process namespace: biological_process alt_id: GO:0009122 alt_id: GO:0009393 def: "The chemical reactions and pathways involving a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009117 ! nucleotide metabolic process [Term] id: GO:0009263 name: deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide anabolism" EXACT [] synonym: "deoxyribonucleotide biosynthesis" EXACT [] synonym: "deoxyribonucleotide formation" EXACT [] synonym: "deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009165 ! nucleotide biosynthetic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009264 name: deoxyribonucleotide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a deoxyribonucleotide, a compound consisting of deoxyribonucleoside (a base linked to a deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "deoxyribonucleotide breakdown" EXACT [] synonym: "deoxyribonucleotide catabolism" EXACT [] synonym: "deoxyribonucleotide degradation" EXACT [] is_a: GO:0009166 ! nucleotide catabolic process is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009265 name: 2'-deoxyribonucleotide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide anabolism" EXACT [] synonym: "2'-deoxyribonucleotide biosynthesis" EXACT [] synonym: "2'-deoxyribonucleotide formation" EXACT [] synonym: "2'-deoxyribonucleotide synthesis" EXACT [] is_a: GO:0009263 ! deoxyribonucleotide biosynthetic process is_a: GO:0009394 ! 2'-deoxyribonucleotide metabolic process [Term] id: GO:0009266 name: response to temperature stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a temperature stimulus." [GOC:hb] subset: gosubset_prok synonym: "response to thermal stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009267 name: cellular response to starvation namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment." [GOC:jl] subset: gosubset_prok is_a: GO:0031669 ! cellular response to nutrient levels is_a: GO:0033554 ! cellular response to stress is_a: GO:0042594 ! response to starvation [Term] id: GO:0009268 name: response to pH namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009269 name: response to desiccation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a desiccation stimulus, extreme dryness resulting from the prolonged deprivation of water." [GOC:jl] subset: gosubset_prok synonym: "desiccation tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009270 name: response to humidity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a humidity stimulus, moisture in the atmosphere." [GOC:jl] is_a: GO:0009415 ! response to water [Term] id: GO:0009271 name: phage shock namespace: biological_process def: "A response by bacterial cells to a variety of stresses including filamentous phage infection, mislocalization of envelope proteins, extremes of temperature, osmolarity or ethanol concentration, and the presence of proton ionophores such as carbonylcyanide m-chlorophenylhydrazone (CCCP), that involves expression of the phage shock protein operon, and acts to protect the bacterial cells from damage." [GOC:add, GOC:jl, PMID:15485810, PMID:16045608] subset: gosubset_prok is_a: GO:0006950 ! response to stress is_a: GO:0009615 ! response to virus [Term] id: GO:0009272 name: fungal-type cell wall biogenesis namespace: biological_process def: "The process by which a fungal-type cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin." [GOC:go_curators, GOC:mtg_sensu] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] synonym: "chitin- and beta-glucan-containing cell wall biogenesis" NARROW [] is_a: GO:0042546 ! cell wall biogenesis [Term] id: GO:0009273 name: peptidoglycan-based cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the peptidoglycan-based cell wall. An example of this process is found in Escherichia coli." [GOC:go_curators] subset: gosubset_prok synonym: "cell envelope biosynthesis" BROAD [] synonym: "cell envelope biosynthetic process" BROAD [] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] is_a: GO:0042546 ! cell wall biogenesis [Term] id: GO:0009274 name: peptidoglycan-based cell wall namespace: cellular_component def: "A protective structure outside the cytoplasmic membrane composed of peptidoglycan (also known as murein), a molecule made up of a glycan (sugar) backbone of repetitively alternating N-acetylglucosamine and N-acetylmuramic acid with short, attached, cross-linked peptide chains containing unusual amino acids. An example of this component is found in Escherichia coli." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "envelope" BROAD [] synonym: "murein sacculus" RELATED [] synonym: "peptidoglycan" NARROW [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009275 name: Gram-positive-bacterium-type cell wall namespace: cellular_component def: "A layer of peptidoglycan found outside of the cytoplasmic membrane. The peptidoglycan is relatively thick (20-80nm) and retains the primary stain of the Gram procedure, thus cells appear blue after Gram stain. The cell walls often contain teichoic acids (acidic anionic polysaccharides) bound to the peptidoglycan. Examples of this component are found in Gram-positive bacteria." [GOC:mlg, ISBN:0051406910, ISBN:0815108893] subset: gosubset_prok synonym: "20-80nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall of Gram-positive Bacteria" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall [Term] id: GO:0009276 name: Gram-negative-bacterium-type cell wall namespace: cellular_component def: "The peptidoglycan layer of the Gram-negative cell envelope. In Gram-negative cells the peptidoglycan is relatively thin (1-2nm) and is linked to the outer membrane by lipoproteins. In Gram-negative cells the peptidoglycan is too thin to retain the primary stain in the Gram staining procedure and therefore cells appear red after Gram stain." [GOC:mlg, ISBN:0815108893] subset: gosubset_prok synonym: "1-2nm peptidoglycan-based cell wall" EXACT [] synonym: "cell wall inner membrane" EXACT [] is_a: GO:0009274 ! peptidoglycan-based cell wall relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009277 name: fungal-type cell wall namespace: cellular_component def: "A rigid yet dynamic structure surrounding the plasma membrane that affords protection from stresses and contributes to cell morphogenesis, consisting of extensively cross-linked glycoproteins and carbohydrates. The glycoproteins may be modified with N- or O-linked carbohydrates, or glycosylphosphatidylinositol (GPI) anchors; the polysaccharides are primarily branched glucans, including beta-linked and alpha-linked glucans, and may also include chitin and other carbohydrate polymers, but not cellulose or pectin. Enzymes involved in cell wall biosynthesis are also found in the cell wall. Note that some forms of fungi develop a capsule outside of the cell wall under certain circumstances; this is considered a separate structure." [GOC:mcc, GOC:mtg_sensu, ISBN:3540601864, PMID:11283274, PMID:16927300, PMID:3319422] synonym: "beta-glucan-containing cell wall" RELATED [] synonym: "chitin- and beta-glucan-containing cell wall" NARROW [] synonym: "chitin-containing cell wall" RELATED [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009278 name: murein sacculus namespace: cellular_component def: "OBSOLETE. A peptidoglycan polymer that forms the shape-determining structure of the cell all of Gram-negative bacteria." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. is_obsolete: true consider: GO:0009276 [Term] id: GO:0009279 name: cell outer membrane namespace: cellular_component def: "A lipid bilayer that forms the outermost layer of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures." [GOC:mtg_sensu, ISBN:0135712254] subset: gosubset_prok synonym: "outer membrane of cell" EXACT [] is_a: GO:0019867 ! outer membrane is_a: GO:0044462 ! external encapsulating structure part intersection_of: GO:0019867 ! outer membrane intersection_of: part_of GO:0030313 ! cell envelope relationship: part_of GO:0030313 ! cell envelope [Term] id: GO:0009280 name: cell wall inner membrane namespace: cellular_component def: "OBSOLETE. In Gram-negative bacteria the membrane that separates the cytoplasm from the murein sacculus." [GOC:ma] comment: This term was made obsolete because it was defined inaccurately. synonym: "cytoplasmic membrane" BROAD [] is_obsolete: true consider: GO:0009276 [Term] id: GO:0009288 name: bacterial-type flagellum namespace: cellular_component def: "A motor complex composed of an extracellular helical protein filament coupled to a rotary motor embedded in the cell envelope." [GOC:jh2, GOC:mtg_sensu, PMID:7787060] subset: gosubset_prok synonym: "flagellin-based flagellum" EXACT [] is_a: GO:0019861 ! flagellum is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0009289 name: pilus namespace: cellular_component def: "A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter." [GOC:pamgo_curators] subset: goslim_pir subset: gosubset_prok synonym: "fimbria" EXACT [] synonym: "fimbriae" EXACT [] synonym: "fimbrium" EXACT [] synonym: "pili" EXACT [] xref: Wikipedia:Pilus is_a: GO:0042995 ! cell projection [Term] id: GO:0009290 name: DNA import into cell involved in transformation namespace: biological_process def: "The directed movement of DNA into a cell that contributes to the process of transformation, the uptake of foreign genetic material into a cell." [GOC:ai] subset: gosubset_prok synonym: "cellular DNA import during transformation" RELATED [] synonym: "cellular DNA uptake" BROAD [] synonym: "DNA import into cell" BROAD [] synonym: "DNA import into cell involved in transformation" RELATED [GOC:dph, GOC:tb] synonym: "DNA transport into cell during transformation" RELATED [] is_a: GO:0051027 ! DNA transport relationship: part_of GO:0009294 ! DNA mediated transformation [Term] id: GO:0009291 name: unidirectional conjugation namespace: biological_process def: "The process of unidirectional (polarized) transfer of genetic information involving direct cellular contact between a donor and recipient cell; the contact is followed by the formation of a cellular bridge that physically connects the cells; some or all of the chromosome(s) of one cell ('male') is then transferred into the other cell ('female'); unidirectional conjugation occurs between cells of different mating types. Examples of this process are found in Prokaryotes." [ISBN:0387520546] subset: gosubset_prok synonym: "mating" BROAD [] is_a: GO:0000746 ! conjugation is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009292 name: genetic transfer namespace: biological_process def: "In the absence of a sexual life cycle, the process involved in the introduction of genetic information to create a genetically different individual." [GOC:clt] subset: goslim_pir subset: gosubset_prok synonym: "genetic exchange" BROAD [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009293 name: transduction namespace: biological_process def: "The transfer of genetic information to a bacterium from a bacteriophage or between bacterial or yeast cells mediated by a phage vector." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: Wikipedia:Transduction_(genetics) is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009294 name: DNA mediated transformation namespace: biological_process def: "The introduction and uptake of foreign genetic material (DNA or RNA) into a cell, and often the expression of that genetic material." [Wikipedia:Transformation_(genetics)] subset: gosubset_prok synonym: "DNA-mediated transformation" EXACT [] is_a: GO:0009292 ! genetic transfer [Term] id: GO:0009295 name: nucleoid namespace: cellular_component def: "The region of a bacterial cell, mitochondrion or chloroplast to which the DNA is confined." [GOC:ma, ISBN:3540076689] subset: gosubset_prok xref: Wikipedia:Nucleoid is_a: GO:0043232 ! intracellular non-membrane-bounded organelle [Term] id: GO:0009296 name: flagellum assembly namespace: biological_process def: "The assembly of a flagellum. In bacteria, this is a whiplike motility appendage present on the surface of some species; in eukaryotes, flagella are threadlike protoplasmic extensions used to propel flagellates and sperm. Flagella are composed of flagellin and have the same basic structure as cilia but are longer in proportion to the cell and present in much smaller numbers." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "flagella assembly" EXACT [GOC:mah] synonym: "flagella biogenesis" RELATED [] synonym: "flagellum biogenesis" RELATED [GOC:mah] is_a: GO:0030031 ! cell projection assembly is_a: GO:0043064 ! flagellum organization [Term] id: GO:0009297 name: pilus assembly namespace: biological_process def: "The assembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. Pili are variously involved in transfer of nucleic acids, adherence to surfaces, and formation of pellicles. Is required for bacterial conjugation, or can play a role in adherence to surfaces (when it is called a fimbrium), and in the formation of pellicles." [GOC:dgh, GOC:mcc2, GOC:tb] subset: gosubset_prok synonym: "fimbria assembly" NARROW [] synonym: "fimbria biogenesis" RELATED [] synonym: "fimbriae assembly" NARROW [] synonym: "fimbriae biogenesis" RELATED [] synonym: "fimbrial assembly" NARROW [] synonym: "fimbrial biogenesis" NARROW [] synonym: "fimbrium assembly" NARROW [] synonym: "fimbrium biogenesis" RELATED [] synonym: "pili biosynthesis" EXACT [] synonym: "pili biosynthetic process" EXACT [] synonym: "pilus biogenesis" RELATED [] synonym: "pilus biosynthesis" EXACT [] synonym: "pilus formation" EXACT [GOC:dph, GOC:tb] is_a: GO:0030031 ! cell projection assembly is_a: GO:0043711 ! pilus organization [Term] id: GO:0009298 name: GDP-mannose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate." [GOC:ai] subset: gosubset_prok synonym: "GDP-mannose anabolism" EXACT [] synonym: "GDP-mannose biosynthesis" EXACT [] synonym: "GDP-mannose formation" EXACT [] synonym: "GDP-mannose synthesis" EXACT [] is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019307 ! mannose biosynthetic process is_a: GO:0019673 ! GDP-mannose metabolic process [Term] id: GO:0009299 name: mRNA transcription namespace: biological_process alt_id: GO:0061023 def: "The cellular synthesis of messenger RNA (mRNA) from a DNA template." [GOC:jl] subset: gosubset_prok synonym: "cellular mRNA transcription" EXACT [] synonym: "mRNA biosynthesis" BROAD [] synonym: "mRNA biosynthetic process" BROAD [] synonym: "mRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009300 name: antisense RNA transcription namespace: biological_process def: "The synthesis of antisense RNA, an RNA molecule complementary in sequence to another RNA or DNA molecule, which, by binding the latter, acts to inhibit its function and/or completion of synthesis, on a template of DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0042868 ! antisense RNA metabolic process [Term] id: GO:0009301 name: snRNA transcription namespace: biological_process def: "The synthesis of small nuclear RNA (snRNA) from a DNA template." [GOC:jl, ISBN:0321000382] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009302 name: snoRNA transcription namespace: biological_process def: "The synthesis of small nucleolar RNA (snoRNA) from a DNA template." [GOC:jl] is_a: GO:0006351 ! transcription, DNA-dependent is_a: GO:0016074 ! snoRNA metabolic process [Term] id: GO:0009303 name: rRNA transcription namespace: biological_process def: "The synthesis of ribosomal RNA (rRNA), any RNA that forms part of the ribosomal structure, from a DNA template." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "rRNA biosynthesis" BROAD [] synonym: "rRNA biosynthetic process" BROAD [] synonym: "rRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009304 name: tRNA transcription namespace: biological_process def: "The synthesis of transfer RNA (tRNA) from a DNA template." [GOC:jl] subset: gosubset_prok synonym: "tRNA biosynthesis" BROAD [] synonym: "tRNA biosynthetic process" BROAD [] synonym: "tRNA synthesis" BROAD [] is_a: GO:0006351 ! transcription, DNA-dependent [Term] id: GO:0009305 name: protein amino acid biotinylation namespace: biological_process def: "The addition of biotin (vitamin B7 / vitamin H) to a protein amino acid." [GOC:ai] subset: gosubset_prok is_a: GO:0043687 ! post-translational protein modification [Term] id: GO:0009306 name: protein secretion namespace: biological_process alt_id: GO:0045166 alt_id: GO:0045731 def: "The controlled release of proteins from a cell or group of cells." [GOC:ai] subset: gosubset_prok synonym: "glycoprotein secretion" NARROW [] synonym: "protein secretion during cell fate commitment" NARROW [] synonym: "protein secretion resulting in cell fate commitment" NARROW [] is_a: GO:0015031 ! protein transport is_a: GO:0032940 ! secretion by cell [Term] id: GO:0009307 name: DNA restriction-modification system namespace: biological_process def: "Any process that protect an organism from invading foreign DNA by methylation of self DNA at specific sequences and nucleolytic cleavage of unmethylated foreign DNA." [GOC:mah] subset: gosubset_prok synonym: "DNA restriction" BROAD [] is_a: GO:0006304 ! DNA modification [Term] id: GO:0009308 name: amine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving any organic compound that is weakly basic in character and contains an amino or a substituted amino group, as carried out by individual cells. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: goslim_pir subset: gosubset_prok synonym: "amine metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0009309 name: amine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine anabolism" EXACT [] synonym: "amine biosynthesis" EXACT [] synonym: "amine formation" EXACT [] synonym: "amine synthesis" EXACT [] is_a: GO:0009308 ! amine metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0009310 name: amine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of any organic compound that is weakly basic in character and contains an amino or a substituted amino group. Amines are called primary, secondary, or tertiary according to whether one, two, or three carbon atoms are attached to the nitrogen atom." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "amine breakdown" EXACT [] synonym: "amine catabolism" EXACT [] synonym: "amine degradation" EXACT [] is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0009311 name: oligosaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide metabolism" EXACT [] is_a: GO:0005975 ! carbohydrate metabolic process [Term] id: GO:0009312 name: oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide anabolism" EXACT [] synonym: "oligosaccharide biosynthesis" EXACT [] synonym: "oligosaccharide formation" EXACT [] synonym: "oligosaccharide synthesis" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016051 ! carbohydrate biosynthetic process [Term] id: GO:0009313 name: oligosaccharide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of oligosaccharides, molecules with between two and (about) 20 monosaccharide residues connected by glycosidic linkages." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "oligosaccharide breakdown" EXACT [] synonym: "oligosaccharide catabolism" EXACT [] synonym: "oligosaccharide degradation" EXACT [] is_a: GO:0009311 ! oligosaccharide metabolic process is_a: GO:0016052 ! carbohydrate catabolic process [Term] id: GO:0009314 name: response to radiation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electromagnetic radiation stimulus. Electromagnetic radiation is a propagating wave in space with electric and magnetic components. These components oscillate at right angles to each other and to the direction of propagation." [GOC:jl, Wikipedia:Electromagnetic_radiation] comment: Note that 'radiation' refers to electromagnetic radiation of any wavelength. subset: gosubset_prok synonym: "response to electromagnetic radiation stimulus" EXACT [] synonym: "response to radiation stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009315 name: drug resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0042493 [Term] id: GO:0009316 name: 3-isopropylmalate dehydratase complex namespace: cellular_component def: "A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate." [BRENDA:4.2.1.33, GOC:jl, MetaCyc:3-ISOPROPYLMALISOM-CPLX, PMID:7026530] comment: See also the molecular function term '3-isopropylmalate dehydratase activity ; GO:0003861'. subset: gosubset_prok synonym: "isopropylmalate isomerase complex" EXACT [] xref: MetaCyc:3-ISOPROPYLMALISOM-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044445 ! cytosolic part [Term] id: GO:0009317 name: acetyl-CoA carboxylase complex namespace: cellular_component def: "A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex." [GOC:jl, GOC:mah, PMID:12121720] subset: goslim_pir subset: gosubset_prok synonym: "ACCase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009318 name: exodeoxyribonuclease VII complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage in either 5' to 3' or 3' to 5' direction to yield nucleoside 5'-phosphates; it prefers single-stranded DNA." [EC:3.1.11.6] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009319 name: cytochrome o ubiquinol oxidase complex namespace: cellular_component def: "A protein complex that possesses cytochrome o ubiquinol oxidase activity; consists of four polypeptide subunits and associated prosthetic groups." [GOC:mah, MetaCyc:CYT-O-UBIOX-CPLX, PMID:11017202, PMID:3052268] comment: See also the molecular function term 'cytochrome o ubiquinol oxidase activity ; GO:0008827'. subset: gosubset_prok xref: MetaCyc:CYT-O-UBIOX-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part relationship: part_of GO:0016021 ! integral to membrane [Term] id: GO:0009320 name: phosphoribosylaminoimidazole carboxylase complex namespace: cellular_component def: "A protein complex that possesses phosphoribosylaminoimidazole carboxylase activity." [GOC:mah] comment: See also the molecular function term 'phosphoribosylaminoimidazole carboxylase activity ; GO:0004638'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009321 name: alkyl hydroperoxide reductase complex namespace: cellular_component def: "An enzyme complex, usually a homodimer, which directly reduces cellular levels of organic hydroperoxides." [BRENDA:1.11.1.15, GOC:jl, PMID:2649484] comment: See also the molecular function term 'alkyl hydroperoxide reductase activity ; GO:0008785'. is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009322 name: trimethylamine-N-oxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the reduction of trimethylamine N-oxide to trimethylamine." [EC:1.6.6.9] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009323 name: ribosomal-protein-alanine N-acetyltransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of an acetyl group to ribosomal-protein alanine, forming ribosomal-protein acetylalanine." [EC:2.3.1.128] is_a: GO:0031248 ! protein acetyltransferase complex [Term] id: GO:0009324 name: D-amino-acid dehydrogenase complex namespace: cellular_component def: "A protein complex that possesses D-amino-acid dehydrogenase activity." [GOC:mah] comment: See also the molecular function term 'D-amino-acid oxidase activity ; GO:0003884'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009325 name: nitrate reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of nitrate from nitrite with the concomitant reduction of an acceptor." [EC:1.7.99.4] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009326 name: formate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of formate to produce carbon dioxide (CO2)." [EC:1.2.1.2] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009327 name: NAD(P)+ transhydrogenase complex (AB-specific) namespace: cellular_component def: "A protein complex that possesses NAD(P)+ transhydrogenase (AB-specific) activity. Homodimeric, trimeric, and heterotetrameric complexes have been identified." [BRENDA:1.6.1.2, GOC:mah] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009328 name: phenylalanine-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of phenylalanine to tRNA(Phe), forming L-phenylalanyl-tRNA(Phe)." [EC:6.1.1.20] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009329 name: acetate CoA-transferase complex namespace: cellular_component def: "A heterotetrameric enzyme complex made up of two alpha subunits and two beta subunits. Part of the acetyl-CoA carboxylase complex. Catalyzes the transfer of a carboxyl group to form malonyl-CoA." [GOC:jl, PMID:2719476, PMID:8423010] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009330 name: DNA topoisomerase complex (ATP-hydrolyzing) namespace: cellular_component def: "Complex that possesses DNA topoisomerase (ATP-hydrolyzing) activity." [GOC:mah] comment: See also the molecular function term 'DNA topoisomerase (ATP-hydrolyzing) activity ; GO:0003918'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009331 name: glycerol-3-phosphate dehydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the dehydrogenation of sn-glycerol 3-phosphate to form glycerone phosphate." [EC:1.1.99.5] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009332 name: glutamate-tRNA ligase complex namespace: cellular_component def: "An enzyme complex that catalyzes the ligation of glutamate and tRNA(Glu) to form glutamyl-tRNA(Glu)." [EC:6.1.1.17] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009333 name: cysteine synthase complex namespace: cellular_component def: "Cysteine synthase is a multienzyme complex made up, in E. coli, of the heteromeric hexamer serine acetyltransferase and the homodimer O-acetylserine (thiol)-lyase A." [EC:4.2.99.8, MetaCyc:CYSSYNMULTI-CPLX] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009334 name: 3-phenylpropionate dioxygenase complex namespace: cellular_component def: "Enzyme complex consisting of four proteins: the two subunits of the hydroxylase component (hcaE and hcaF), a ferredoxin (hcaC) and a ferredoxin reductase (hcaD). Converts 3-phenylpropionic acid (PP) into cis-3-(3-carboxyethyl)-3,5-cyclohexadiene-1,2-diol (PP-dihydrodiol)." [GOC:jl, MetaCyc:HCAMULTI-CPLX, PMID:9603882] comment: See also the molecular function term '3-phenylpropionate dioxygenase activity ; GO:0008695'. xref: MetaCyc:HCAMULTI-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009335 name: holo-[acyl-carrier protein] synthase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the formation of holo-[acyl-carrier protein] from CoA and apo-[acyl-carrier protein]." [EC:2.7.8.7] comment: This term was made obsolete because the catalytic activity resides in a single polypeptide rather than a complex, and the complex is represented by a different GO term. synonym: "holo-ACP synthase complex" EXACT [] is_obsolete: true consider: GO:0005835 [Term] id: GO:0009336 name: sulfate adenylyltransferase complex (ATP) namespace: cellular_component def: "An enzyme complex that catalyzes the formation adenylylsulfate from sulfate and ATP." [EC:2.7.7.4] synonym: "sulphate adenylyltransferase complex (ATP)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009337 name: sulfite reductase complex (NADPH) namespace: cellular_component def: "A multisubunit iron flavoprotein, which in yeast is composed of 2 alpha and 2 beta subunits. Catalyzes the reduction of sulfite to sulfide." [BRENDA:1.8.1.2, GOC:jl] comment: See also the molecular function term 'sulfite reductase (NADPH) activity ; GO:0004783'. subset: gosubset_prok synonym: "sulphite reductase complex (NADPH)" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009338 name: exodeoxyribonuclease V complex namespace: cellular_component def: "An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA." [EC:3.1.11.5] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009339 name: glycolate oxidase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of 2-hydroxy acid to form 2-oxo acid and hydrogen peroxide (H2O2). The enzyme is a flavoprotein (FMN)." [EC:1.1.3.15] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009340 name: DNA topoisomerase IV complex namespace: cellular_component def: "A heterodimeric enzyme, which in most bacterial species is composed of two subunits, ParC and ParE. Functions in chromosome segregation and can relax supercoiled DNA." [GOC:jl, PMID:7783632] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009341 name: beta-galactosidase complex namespace: cellular_component def: "A multimeric enzyme complex that in E. coli is a heterooctamer made up of four alpha subunits and four beta subunits. Catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides." [EC:3.2.1.23, PMID:15950161] subset: gosubset_prok is_a: GO:0043234 ! protein complex [Term] id: GO:0009342 name: glutamate synthase complex (NADPH) namespace: cellular_component def: "A complex that possesses glutamate synthase (NADPH) activity." [EC:1.4.1.13, GOC:mah] subset: gosubset_prok is_a: GO:0031026 ! glutamate synthase complex [Term] id: GO:0009343 name: biotin carboxylase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of carboxybiotin-carboxyl-carrier protein from biotin-carboxyl-carrier protein and carbon dioxide (CO2)." [EC:6.3.4.14] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0009317 ! acetyl-CoA carboxylase complex [Term] id: GO:0009344 name: nitrite reductase complex [NAD(P)H] namespace: cellular_component def: "Complex that possesses nitrite reductase [NAD(P)H] activity." [GOC:mah] comment: See also the molecular function term 'nitrite reductase [NAD(P)H] activity ; GO:0008942'. is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009345 name: glycine-tRNA ligase complex namespace: cellular_component def: "A multimeric enzyme complex which, in bacteria, is usually a tetramer of two alpha and two beta chains and in eukaryotes, is usually a homodimer. Functions in the ligation of glycine and tRNA(Gly) to form glycyl-tRNA(Gly)." [EC:6.1.1.14, GOC:jl, PMID:15733854] subset: gosubset_prok synonym: "glycine-tRNA synthetase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009346 name: citrate lyase complex namespace: cellular_component def: "Citrate lyase is a multienzyme complex with three constituents: the alpha subunit, citrate-ACP transferase; the beta subunit, citryl-ACP lyase; and the gamma subunit, an acyl-carrier protein which also carries the prosthetic group components. All three subunits are required for citrate lyase enzyme activity." [EC:4.1.3.6, MetaCyc:ACECITLY-CPLX] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009347 name: aspartate carbamoyltransferase complex namespace: cellular_component def: "A multienzyme complex that catalyzes the formation N-carbamoyl-L-aspartate from carbamoyl phosphate and L-aspartate. It exhibits a variety of architectural organizations, but in all microorganisms the core catalytic component is a homotrimer of approximately 34 kDa polypeptides." [PMID:10447693] comment: Note that in eukaryotes, aspartate carbamoyltransferase is usually a single polypeptide, not a complex, and should therefore not be annotated to this component term. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009348 name: ornithine carbamoyltransferase complex namespace: cellular_component def: "A homotrimeric protein complex that catalyzes the transfer of a carbamoyl group to ornithine, forming citrulline." [EC:2.1.3.3, GOC:mah] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009349 name: riboflavin synthase complex namespace: cellular_component def: "An flavoprotein that catalyzes the reaction the breakdown of dimethyl(ribityl)lumazine to form riboflavin and ribitylamino-amino-dihydroxypyrimidine." [EC:2.5.1.9] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009350 name: ethanolamine ammonia-lyase complex namespace: cellular_component def: "An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia." [EC:4.3.1.7] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009351 name: dihydrolipoamide S-acyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of an acyl group from coenzyme A to dihydrolipoamide." [EC:2.3.1.12] comment: This term was made obsolete because dihydrolipoamide S-acyltransferase activity resides in a single polypeptide. is_obsolete: true [Term] id: GO:0009352 name: dihydrolipoyl dehydrogenase complex namespace: cellular_component def: "OBSOLETE. Complex that possesses dihydrolipoyl dehydrogenase activity." [GOC:mah] comment: This term was made obsolete because the activity dihydrolipoamide dehydrogenase is held by a single protein (Lpd1 in yeast), which is one of the components of three different complexes: 2-oxoglutarate dehydrogenase, pyruvate dehydrogenase, and branch chain amino acid dehydrogenase, so dihydrolipoamide dehydrogenase is not a complex itself. synonym: "dihydrolipoamide dehydrogenase complex" EXACT [] is_obsolete: true consider: GO:0004148 consider: GO:0045240 consider: GO:0045254 [Term] id: GO:0009353 name: mitochondrial oxoglutarate dehydrogenase complex namespace: cellular_component def: "A complex of multiple copies of three enzymatic components: oxoglutarate dehydrogenase (lipoamide) ; EC:1.2.4.2 (E1), dihydrolipoamide S-succinyltransferase ; EC:2.3.1.61 (E2) and dihydrolipoamide dehydrogenase ; EC:1.8.1.4 (E3); catalyzes the overall conversion of 2-oxoglutarate to succinyl-CoA and carbon dioxide (CO2) within the mitochondrial matrix. An example of this complex is found in Mus musculus." [GOC:mtg_sensu, MetaCyc:CPLX66-42, PMID:10848975] comment: See also the molecular functions term 'oxoglutarate dehydrogenase (succinyl-transferring) activity ; GO:0004591', 'dihydrolipoyllysine-residue succinyltransferase activity ; GO:0004149' and 'dihydrolipoyl dehydrogenase activity ; GO:0004148'. is_a: GO:0044429 ! mitochondrial part is_a: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: GO:0045252 ! oxoglutarate dehydrogenase complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009354 name: dihydrolipoamide S-succinyltransferase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the transfer of succinyl-CoA to dihydrolipoamide to form S-succinyldihydrolipoamide. The enzyme is a component of the multienzyme 2-oxoglutarate dehydrogenase complex." [EC:2.3.1.61] comment: This term was made obsolete because dihydrolipoamide S-succinyltransferase itself is not a complex, it is a component of the 2-oxoglutarate dehydrogenase complex, the activity dihydrolipoamide S-succinyltransferase is contained in a single polypeptide. is_obsolete: true consider: GO:0045252 [Term] id: GO:0009355 name: DNA polymerase V complex namespace: cellular_component def: "A DNA polymerase complex that contains two UmuD' and one UmuC subunits, and acts in translesion DNA synthesis." [PMID:10430871, PMID:10542196] is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009356 name: aminodeoxychorismate synthase complex namespace: cellular_component def: "A heterodimeric protein complex that possesses 4-amino-4-deoxychorismate synthase activity." [PMID:2251281, PMID:7592344] synonym: "4-amino-4-deoxychorismate synthase complex" RELATED [] synonym: "ADC synthase complex" EXACT [] synonym: "p-aminobenzoate synthetase complex" RELATED [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009357 name: protein-N(PI)-phosphohistidine-sugar phosphotransferase complex namespace: cellular_component def: "An enzyme complex that catalyzes the transfer of a phosphate from protein N(PI)-phosphohistidine to a sugar molecule. It is enzyme II of the phosphotransferase system." [EC:2.7.1.69] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009358 name: polyphosphate kinase complex namespace: cellular_component def: "A protein complex that possesses polyphosphate kinase activity." [GOC:mah] comment: See also the molecular function term 'polyphosphate kinase activity ; GO:0008976'. subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009359 name: Type II site-specific deoxyribonuclease complex namespace: cellular_component def: "A protein complex that functions as an endonuclease to cleave DNA at or near a specific recognition site, when that site is unmethylated. These complexes may be dimers or tetramers; it is also possible for the endonuclease to be in a complex with the corresponding methyltransferase that methylates the recognition site. DNA restriction systems such as this are used by bacteria to defend against phage and other foreign DNA that may enter a cell." [PMID:12654995] subset: gosubset_prok synonym: "Type II restriction enzyme complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009360 name: DNA polymerase III complex namespace: cellular_component def: "A DNA polymerase complex that contains two complexes of the catalytic alpha, beta, delta and epsilon polymerase/exonuclease subunits, plus the DnaX complex, a heptamer that includes the tau and gamma products of the dnaX gene and confers structural asymmetry that allows the polymerase to replicate both leading and lagging strands." [PMID:11525729, PMID:12940977] subset: gosubset_prok is_a: GO:0042575 ! DNA polymerase complex [Term] id: GO:0009361 name: succinate-CoA ligase complex (ADP-forming) namespace: cellular_component def: "A heterodimeric enzyme complex, composed of an alpha and beta chain, most usually found in (but not limited to) bacteria. Functions in the TCA cycle, hydrolyzing succinyl-CoA into succinate and CoA, thereby forming ATP." [EC:6.2.1.5, GOC:jl] subset: gosubset_prok synonym: "succinyl-CoA synthetase, ADP-forming" EXACT [CORUM:394] is_a: GO:0042709 ! succinate-CoA ligase complex [Term] id: GO:0009365 name: protein histidine kinase complex namespace: cellular_component def: "A complex that possesses protein histidine kinase activity." [GOC:mah] is_a: GO:0043234 ! protein complex [Term] id: GO:0009366 name: enterobactin synthetase complex namespace: cellular_component def: "A multienzyme complex usually composed of four proteins, EntB, EntD, EntE and EntF. Plays a role in the enterobactin biosynthesis pathway." [MetaCyc:ENTMULTI-CPLX, PMID:9485415] subset: gosubset_prok synonym: "enterochelin synthetase complex" EXACT [] xref: MetaCyc:ENTMULTI-CPLX is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009367 name: prepilin peptidase complex namespace: cellular_component def: "OBSOLETE. An enzyme complex that catalyzes the cleavage of a Gly-Phe bond to release an N-terminal, basic peptide of 5-8 residues from type IV prepilin, and then N-methylates the new N-terminal amino group." [EC:3.4.23.43] comment: This term was made obsolete because prepilin peptidase is a single gene product, and there is no evidence that it acts as a multimer. is_obsolete: true [Term] id: GO:0009368 name: endopeptidase Clp complex namespace: cellular_component def: "A protein complex comprised of members of the ClpX, ClpC, ClpD, ClpP or ClpR protein families. ClpPs are the proteolytic subunit of active complexes, and ClpA and ClpX form the regulatory subunits. Enzymatically active and inactive complexes can form." [GOC:mah, PMID:11352464] subset: goslim_pir subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009369 name: quorum sensing signal generator activity namespace: molecular_function subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0009370 name: quorum sensing response regulator activity namespace: molecular_function subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity [Term] id: GO:0009371 name: positive regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that activates or increases the rate of transcription." [GOC:go_curators] subset: gosubset_prok synonym: "activation of transcription by pheromones" NARROW [] synonym: "stimulation of transcription by pheromones" NARROW [] synonym: "up regulation of transcription by pheromones" EXACT [] synonym: "up-regulation of transcription by pheromones" EXACT [] synonym: "upregulation of transcription by pheromones" EXACT [] is_a: GO:0009373 ! regulation of transcription by pheromones is_a: GO:0045893 ! positive regulation of transcription, DNA-dependent [Term] id: GO:0009372 name: quorum sensing namespace: biological_process def: "The process by which single-celled organisms monitor their population density by detecting the concentration of small, diffusible signal molecules produced by the cells themselves." [PMID:15716452, PMID:8288518] subset: goslim_pir subset: gosubset_prok synonym: "quorum sensing system" EXACT [] xref: Wikipedia:Quorum_sensing is_a: GO:0048874 ! homeostasis of number of cells in a free-living population [Term] id: GO:0009373 name: regulation of transcription by pheromones namespace: biological_process def: "Any process involving pheromones that modulates the frequency, rate or extent of transcription." [GOC:go_curators] subset: gosubset_prok is_a: GO:0006355 ! regulation of transcription, DNA-dependent is_a: GO:0071444 ! cellular response to pheromone [Term] id: GO:0009374 name: biotin binding namespace: molecular_function def: "Interacting selectively and non-covalently with biotin (cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid), the (+) enantiomer of which is very widely distributed in cells and serves as a carrier in a number of enzymatic beta-carboxylation reactions." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "vitamin B7 binding" EXACT [] synonym: "vitamin H binding" EXACT [] is_a: GO:0019842 ! vitamin binding is_a: GO:0033293 ! monocarboxylic acid binding [Term] id: GO:0009375 name: ferredoxin hydrogenase complex namespace: cellular_component def: "An enzyme complex that catalyzes the oxidation of reduced ferredoxin. Hydrogenase contains iron-sulfur clusters, and some contain nickel; it can use molecular hydrogen for the reduction of a variety of substances." [EC:1.12.7.2] subset: gosubset_prok synonym: "hydrogenase complex" BROAD [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009376 name: HslUV protease complex namespace: cellular_component def: "A protein complex that possesses ATP-dependent protease activity; consists of an ATPase large subunit with homology to other Clp family ATPases and a peptidase small subunit related to the proteasomal beta-subunits of eukaryotes. In the E. coli complex, six identical subunits of both the ATPase, ClpY, and the protease, ClpQ, self-assemble into an oligomeric ring, and two rings of each subunit, two ClpQ rings surrounded by single ClpY rings, form a dumbbell-shaped complex." [PMID:12670962] subset: gosubset_prok synonym: "ClpYQ protease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009377 name: HslUV protease activity namespace: molecular_function def: "OBSOLETE. Catalysis of the ATP-dependent hydrolysis of peptide bonds in substrates including E. coli SulA and misfolded proteins." [GOC:mah, PMID:10368141] comment: This term was made obsolete because it represents a gene product. subset: gosubset_prok is_obsolete: true replaced_by: GO:0070011 [Term] id: GO:0009378 name: four-way junction helicase activity namespace: molecular_function def: "Catalysis of the unwinding of the DNA helix of DNA containing four-way junctions, including Holliday junctions." [GOC:jl, PMID:9442895] subset: gosubset_prok synonym: "Holliday junction helicase activity" NARROW [] is_a: GO:0003678 ! DNA helicase activity [Term] id: GO:0009379 name: Holliday junction helicase complex namespace: cellular_component def: "A DNA helicase complex that forms part of a Holliday junction resolvase complex, where the helicase activity is involved in the migration of the junction branch point. The best-characterized example is the E. coli RuvAB complex, in which a hexamer of RuvB subunits possesses helicase activity that is modulated by association with RuvA ." [PMID:16935884, PMID:9442895] subset: gosubset_prok is_a: GO:0033202 ! DNA helicase complex intersection_of: GO:0033202 ! DNA helicase complex intersection_of: part_of GO:0048476 ! Holliday junction resolvase complex relationship: part_of GO:0048476 ! Holliday junction resolvase complex [Term] id: GO:0009380 name: excinuclease repair complex namespace: cellular_component def: "Any of the protein complexes formed by the UvrABC excinuclease system, which carries out nucleotide excision repair. Three different complexes are formed by the 3 proteins as they proceed through the excision repair process. First a complex consisting of two A subunits and one B subunit bind DNA and unwind it around the damaged site. Then, the A subunits disassociate leaving behind a stable complex between subunit B and DNA. Now, subunit C binds to this B+DNA complex and causes subunit B to nick the DNA on one side of the complex while subunit C nicks the DNA on the other side of the complex. DNA polymerase I and DNA ligase can then repair the resulting gap." [GOC:mah, GOC:mlg, PMID:15192705] subset: gosubset_prok synonym: "excinuclease ABC complex" EXACT [] synonym: "UvrABC excinuclease complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0009381 name: excinuclease ABC activity namespace: molecular_function def: "Catalysis of the hydrolysis of ester linkages within deoxyribonucleic acid at sites flanking regions of damaged DNA to which the Uvr ABC excinuclease complexes bind." [GOC:mah, PMID:15192705] subset: gosubset_prok is_a: GO:0004520 ! endodeoxyribonuclease activity [Term] id: GO:0009382 name: imidazoleglycerol-phosphate synthase complex namespace: cellular_component def: "Complex that possesses imidazoleglycerol-phosphate synthase activity." [GOC:mah] comment: See also the molecular function term 'imidazoleglycerol-phosphate synthase activity ; GO:0000107'. subset: gosubset_prok synonym: "imidazoleglycerol phosphate synthase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009383 name: rRNA (cytosine-C5-)-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to cytosine to form 5-methylcytosine in small subunit ribosomal RNA." [GOC:imk, PMID:10026269, PMID:18786544] synonym: "rRNA (cytosine-C5-967)-methyltransferase activity" NARROW [] synonym: "rRNA m5C967 methyltransferase activity" NARROW [] xref: EC:2.1.1.- is_a: GO:0008169 ! C-methyltransferase activity is_a: GO:0016434 ! rRNA (cytosine) methyltransferase activity [Term] id: GO:0009384 name: N-acylmannosamine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + N-acyl-D-mannosamine = ADP + N-acyl-D-mannosamine 6-phosphate." [EC:2.7.1.60] subset: gosubset_prok synonym: "acetylamidodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "acylaminodeoxymannokinase activity" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase (phosphorylating)" EXACT [EC:2.7.1.60] synonym: "acylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acetylmannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "ATP:N-acyl-D-mannosamine 6-phosphotransferase activity" EXACT [EC:2.7.1.60] synonym: "N-acetylmannosamine kinase activity" EXACT [EC:2.7.1.60] synonym: "N-acyl-D-mannosamine kinase activity" EXACT [EC:2.7.1.60] xref: EC:2.7.1.60 xref: MetaCyc:N-ACYLMANNOSAMINE-KINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009385 name: N-acylmannosamine-6-phosphate 2-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: N-acetyl-D-mannosamine-6-phosphate = N-acetyl-D-glucosamine-6-phosphate." [MetaCyc:NANE-RXN] synonym: "N-acylmannosamine-6-P epimerase activity" EXACT [] xref: EC:5.-.-.- xref: MetaCyc:NANE-RXN is_a: GO:0016853 ! isomerase activity [Term] id: GO:0009386 name: translational attenuation namespace: biological_process def: "Translational attenuation is a regulatory mechanism analogous to ribosome-mediated transcriptional attenuation. The system requires the presence of a short ORF, called a leader peptide, encoded in the mRNA upstream of the ribosome-binding site and start codon of the gene whose translation is to be regulated. Certain conditions, such as presence of the antibiotic tetracycline in bacteria or amino acid starvation, may cause slowing or stalling of the ribosome translating the leader peptide. The stalled ribosome masks a region of the mRNA and affects which of two alternative mRNA folded structures will form, therefore controlling whether or not a ribosome will bind and initiate translation of the downstream gene. Translational attenuation is analogous to ribosome-mediated transcriptional attenuation, in which mRNA remodeling caused by ribosome stalling regulates transcriptional termination rather than translational initiation." [PMID:15694341, PMID:15805513] subset: gosubset_prok is_a: GO:0006417 ! regulation of translation [Term] id: GO:0009388 name: antisense RNA namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:mah] comment: This term was made obsolete because it represents a gene product. is_obsolete: true [Term] id: GO:0009389 name: dimethyl sulfoxide reductase activity namespace: molecular_function def: "Catalysis of the reaction: dimethyl sulfoxide + H+ = dimethyl sulfide + H2O." [UM-BBD_enzymeID:e0188] subset: gosubset_prok synonym: "dimethyl sulphoxide reductase activity" EXACT [] xref: EC:1.8.99.- xref: UM-BBD_enzymeID:e0188 is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: GO:0009390 name: dimethyl sulfoxide reductase complex namespace: cellular_component def: "An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide." [UM-BBD_enzymeID:e0188] synonym: "dimethyl sulphoxide reductase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044464 ! cell part [Term] id: GO:0009391 name: ribonucleotide reductase activating enzyme activity namespace: molecular_function xref: EC:1.97.1.- is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0009392 name: N-acetyl-anhydromuramoyl-L-alanine amidase activity namespace: molecular_function is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0009394 name: 2'-deoxyribonucleotide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a 2'-deoxyribonucleotide, a compound consisting of 2'-deoxyribonucleoside (a base linked to a 2'-deoxyribose sugar) esterified with a phosphate moiety at either the 3' or 5'-hydroxyl group of its glycose moiety." [GOC:mah] subset: gosubset_prok synonym: "2'-deoxyribonucleotide metabolism" EXACT [] is_a: GO:0009262 ! deoxyribonucleotide metabolic process [Term] id: GO:0009395 name: phospholipid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phospholipids, any lipid containing phosphoric acid as a mono- or diester." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "phospholipid breakdown" EXACT [] synonym: "phospholipid catabolism" EXACT [] synonym: "phospholipid degradation" EXACT [] is_a: GO:0006644 ! phospholipid metabolic process is_a: GO:0044242 ! cellular lipid catabolic process [Term] id: GO:0009396 name: folic acid and derivative biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of folic acid and its derivatives." [GOC:ai] subset: gosubset_prok synonym: "folate and derivative biosynthesis" EXACT [] synonym: "folate and derivative biosynthetic process" EXACT [] synonym: "folic acid and derivative anabolism" EXACT [] synonym: "folic acid and derivative biosynthesis" EXACT [] synonym: "folic acid and derivative formation" EXACT [] synonym: "folic acid and derivative synthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthesis" EXACT [] synonym: "vitamin B9 and derivative biosynthetic process" EXACT [] synonym: "vitamin M and derivative biosynthesis" EXACT [] synonym: "vitamin M and derivative biosynthetic process" EXACT [] is_a: GO:0006760 ! folic acid and derivative metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process [Term] id: GO:0009397 name: folic acid and derivative catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of folic acid and its derivatives." [GOC:ai] subset: gosubset_prok synonym: "folate and derivative catabolic process" EXACT [] synonym: "folate and derivative catabolism" EXACT [] synonym: "folic acid and derivative breakdown" EXACT [] synonym: "folic acid and derivative catabolism" EXACT [] synonym: "folic acid and derivative degradation" EXACT [] synonym: "vitamin B9 and derivative catabolic process" EXACT [] synonym: "vitamin B9 and derivative catabolism" EXACT [] synonym: "vitamin M and derivative catabolic process" EXACT [] synonym: "vitamin M and derivative catabolism" EXACT [] is_a: GO:0006760 ! folic acid and derivative metabolic process is_a: GO:0009109 ! coenzyme catabolic process [Term] id: GO:0009398 name: FMN biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "FMN anabolism" EXACT [] synonym: "FMN biosynthesis" EXACT [] synonym: "FMN formation" EXACT [] synonym: "FMN synthesis" EXACT [] is_a: GO:0006746 ! FADH2 metabolic process is_a: GO:0009108 ! coenzyme biosynthetic process is_a: GO:0009156 ! ribonucleoside monophosphate biosynthetic process is_a: GO:0042727 ! riboflavin and derivative biosynthetic process is_a: GO:0046444 ! FMN metabolic process [Term] id: GO:0009399 name: nitrogen fixation namespace: biological_process def: "The process by which nitrogen is taken from its relatively inert molecular form (N2) in the atmosphere and converted into nitrogen compounds useful for other chemical processes, such as ammonia, nitrate and nitrogen dioxide." [Wikipedia:Nitrogen_fixation] subset: gosubset_prok xref: MetaCyc:N2FIX-PWY xref: Wikipedia:Nitrogen_fixation is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0009400 name: receptor signaling protein serine/threonine phosphatase activity namespace: molecular_function synonym: "receptor signalling protein serine/threonine phosphatase activity" EXACT [] is_a: GO:0004722 ! protein serine/threonine phosphatase activity is_a: GO:0005057 ! receptor signaling protein activity [Term] id: GO:0009401 name: phosphoenolpyruvate-dependent sugar phosphotransferase system namespace: biological_process def: "The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC." [http://www.ucs.mun.ca/~n55lrb/general_pts.html] subset: gosubset_prok synonym: "PTS system" NARROW [] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0009402 name: toxin resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:jl] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009636 [Term] id: GO:0009403 name: toxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "toxin anabolism" EXACT [] synonym: "toxin biosynthesis" EXACT [] synonym: "toxin formation" EXACT [] synonym: "toxin synthesis" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009404 name: toxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:cab2] subset: goslim_pir subset: gosubset_prok synonym: "toxin metabolism" EXACT [] is_a: GO:0019748 ! secondary metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009405 name: pathogenesis namespace: biological_process def: "The set of specific processes that generate the ability of an organism to cause disease in another." [GOC:go_curators] comment: Note that this term should not be used to annotate gene products that are involved in the host response to pathogenesis. It should only be used to annotate those gene products involved in the generation of pathogenesis by the pathogen itself. subset: goslim_candida subset: goslim_goa subset: gosubset_prok synonym: "channel-forming toxin activity" RELATED [] synonym: "cytotoxin activity" RELATED [] synonym: "endotoxin activity" RELATED [] synonym: "enterotoxin activity" RELATED [] synonym: "exotoxin activity" RELATED [] synonym: "lipoprotein toxin" RELATED [] synonym: "neurotoxin activity" RELATED [] synonym: "pore-forming toxin activity" RELATED [] synonym: "toxin activity" RELATED [] synonym: "virulence" RELATED [] is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009406 name: virulence namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because it represents a phenotype rather than a biological process. is_obsolete: true consider: GO:0009405 consider: GO:0016032 [Term] id: GO:0009407 name: toxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism." [GOC:go_curators] subset: gosubset_prok synonym: "toxin breakdown" EXACT [] synonym: "toxin catabolism" EXACT [] synonym: "toxin degradation" EXACT [] is_a: GO:0009404 ! toxin metabolic process is_a: GO:0044248 ! cellular catabolic process [Term] id: GO:0009408 name: response to heat namespace: biological_process alt_id: GO:0006951 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism." [GOC:lr] subset: gosubset_prok synonym: "response to heat shock" NARROW [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009409 name: response to cold namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism." [GOC:lr] subset: gosubset_prok synonym: "freezing tolerance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009266 ! response to temperature stimulus [Term] id: GO:0009410 name: response to xenobiotic stimulus namespace: biological_process alt_id: GO:0017104 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a xenobiotic compound stimulus. Xenobiotic compounds are compounds foreign to living organisms." [GOC:jl] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009411 name: response to UV namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ultraviolet radiation (UV light) stimulus. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:hb] subset: gosubset_prok synonym: "response to ultraviolet light stimulus" EXACT [] synonym: "response to ultraviolet radiation stimulus" EXACT [] synonym: "response to UV light stimulus" EXACT [] synonym: "response to UV radiation stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009412 name: response to heavy metal namespace: biological_process def: "OBSOLETE. A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a heavy metal stimulus. Heavy metals are those metals that can form a coordination bond with a protein; this definition includes the following biologically relevant heavy metals: Cd, Co, Cu, Fe, Hg, Mn, Mo, Ni, V, W, Zn." [GOC:ai] comment: This term was made obsolete because 'heavy metal' is an ambiguous grouping term which has no set meaning (see Pure Appl. Chem. Vol. 74, No. 5, pp. 793-807, 2002, for more information). is_obsolete: true consider: GO:0010038 [Term] id: GO:0009413 name: response to flooding namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating flooding, short-term immersion in water." [GOC:lr] comment: Note that this term should not be confused with 'response to deep water ; GO:0030912'. Flooding refers to short-term immersion, whereas 'response to deep water ; GO:0030912' refers to standing in water throughout an organism's life cycle. is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009414 name: response to water deprivation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water deprivation stimulus, prolonged deprivation of water." [GOC:lr] subset: gosubset_prok synonym: "drought tolerance" RELATED [] synonym: "response to dehydration" EXACT [] synonym: "response to drought" EXACT [] synonym: "response to thirst" EXACT [] is_a: GO:0006950 ! response to stress is_a: GO:0009415 ! response to water [Term] id: GO:0009415 name: response to water namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a water stimulus." [GOC:jl] subset: gosubset_prok is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009416 name: response to light stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light stimulus, electromagnetic radiation of wavelengths classified as infrared, visible or ultraviolet light." [GOC:go_curators, ISBN:0582227089] subset: gosubset_prok is_a: GO:0009314 ! response to radiation [Term] id: GO:0009417 name: fimbrin namespace: cellular_component def: "OBSOLETE. A class of proteins that are the subunit components of fimbria." [ISBN:0914826859] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0009289 [Term] id: GO:0009418 name: pilus shaft namespace: cellular_component def: "The long, slender, mid section of a pilus." [GOC:jl] subset: gosubset_prok synonym: "fimbrial shaft" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009419 name: pilus tip namespace: cellular_component def: "The pointed extremity furthest from the cell of a pilus." [GOC:jl] subset: gosubset_prok synonym: "fimbrial tip" EXACT [] is_a: GO:0044443 ! pilus part [Term] id: GO:0009420 name: bacterial-type flagellum filament namespace: cellular_component def: "The long (approximately 20 nm), thin external structure of the flagellum, which acts as a propeller. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament" EXACT [] synonym: "flagellin-based flagellum filament" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009421 name: bacterial-type flagellum filament cap namespace: cellular_component def: "The proteinaceous structure at the distal tip of the flagellar filament. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar filament cap" EXACT [] synonym: "flagellin-based flagellum filament cap" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009420 ! bacterial-type flagellum filament [Term] id: GO:0009422 name: bacterial-type flagellum hook-filament junction namespace: cellular_component def: "The region of the flagellum where the hook and filament meet. Examples of this component are found in bacteria." [GOC:mah, GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook-filament junction" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009423 name: chorismate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the unsymmetrical ether derived from phosphoenolpyruvate and 5-phosphoshikimic acid formed as an intermediate in the biosynthesis of aromatic amino acids and many other compounds." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "chorismate anabolism" EXACT [] synonym: "chorismate biosynthesis" EXACT [] synonym: "chorismate formation" EXACT [] synonym: "chorismate synthesis" EXACT [] xref: MetaCyc:ARO-PWY is_a: GO:0043650 ! dicarboxylic acid biosynthetic process is_a: GO:0046417 ! chorismate metabolic process [Term] id: GO:0009424 name: bacterial-type flagellum hook namespace: cellular_component def: "The portion of the flagellum that connects the filament to the basal body. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar hook" EXACT [] synonym: "flagellin-based flagellum hook" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009425 name: bacterial-type flagellum basal body namespace: cellular_component def: "One of the three major substructures of the flagellin-based flagellum; a structure consisting of a rod, a series of rings, the Mot proteins, the switch complex and the flagellum-specific export apparatus. The rings anchor the flagellum to the cytoplasmic membrane (MS ring), the peptidoglycan (P ring) and the outer membrane (L ring). Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body" BROAD [] synonym: "flagellin-based flagellum basal body" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part [Term] id: GO:0009426 name: bacterial-type flagellum basal body, distal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is distal to the cell membrane; spans most of the distance between the inner and outer membranes. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009427 name: bacterial-type flagellum basal body, distal rod, L ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the outer membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, L ring" EXACT [] synonym: "flagellin-based flagellum basal body, distal rod, L ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009428 name: bacterial-type flagellum basal body, distal rod, P ring namespace: cellular_component def: "One of the rings of the flagellar basal body; anchors the basal body to the peptidoglycan layer. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, distal rod, P ring" RELATED [] synonym: "flagellin-based flagellum basal body, distal rod, P ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009426 ! bacterial-type flagellum basal body, distal rod [Term] id: GO:0009429 name: bacterial-type flagellum basal body, proximal rod namespace: cellular_component def: "The portion of the central rod of the flagellar basal body that is proximal to the cell membrane; proximal rod connects the distal rod to the flagellar motor. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:11133968, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, proximal rod" EXACT [] synonym: "flagellin-based flagellum basal body, proximal rod" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0030694 ! bacterial-type flagellum basal body, rod [Term] id: GO:0009431 name: bacterial-type flagellum basal body, MS ring namespace: cellular_component alt_id: GO:0009430 def: "One of the rings of the flagellar basal body; a double-flanged ring that anchors the basal body to the cytoplasmic membrane. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, mounting plate" BROAD [] synonym: "flagellar basal body, MS ring" EXACT [] synonym: "flagellin-based flagellum basal body, MS ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009432 name: SOS response namespace: biological_process def: "An error-prone process for repairing damaged microbial DNA." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok xref: Wikipedia:SOS_response is_a: GO:0031668 ! cellular response to extracellular stimulus is_a: GO:0033554 ! cellular response to stress [Term] id: GO:0009433 name: bacterial-type flagellum basal body, C ring namespace: cellular_component def: "Cytoplasmic ring located at the base of the flagellar basal body; acts as a rotor; includes three switch proteins, which generate torque and can change their conformational state in a bimodal fashion, so that the motor direction can switch between clockwise and counterclockwise. Examples of this component are found in bacteria." [GOC:mtg_sensu, PMID:10572114, PMID:12624192] subset: gosubset_prok synonym: "flagellar basal body, C ring" EXACT [] synonym: "flagellin-based flagellum basal body, C ring" EXACT [] is_a: GO:0044461 ! bacterial-type flagellum part relationship: part_of GO:0009425 ! bacterial-type flagellum basal body [Term] id: GO:0009434 name: microtubule-based flagellum namespace: cellular_component def: "A long, whiplike protrusion from the surface of a eukaryotic cell, whose undulations drive the cell through a liquid medium; similar in structure to a cilium. The flagellum is based on a 9+2 arrangement of microtubules." [GOC:mtg_sensu, ISBN:0815316194] comment: See also the cellular component term 'cilium ; GO:0005929'. is_a: GO:0019861 ! flagellum is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0009435 name: NAD biosynthetic process namespace: biological_process alt_id: GO:0006736 def: "The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide, a coenzyme present in most living cells and derived from the B vitamin nicotinic acid; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH." [GOC:jl, ISBN:0618254153] subset: gosubset_prok synonym: "NAD (oxidized) biosynthesis" EXACT [] synonym: "NAD (oxidized) biosynthetic process" EXACT [] synonym: "NAD (reduced) biosynthesis" EXACT [] synonym: "NAD (reduced) biosynthetic process" EXACT [] synonym: "NAD anabolism" EXACT [] synonym: "NAD biosynthesis" EXACT [] synonym: "NAD formation" EXACT [] synonym: "NAD synthesis" EXACT [] synonym: "NADH biosynthesis" EXACT [] synonym: "NADH biosynthetic process" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "oxidized NAD biosynthesis" EXACT [] synonym: "oxidized NAD biosynthetic process" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "oxidized nicotinamide adenine dinucleotide biosynthetic process" EXACT [] synonym: "reduced NAD biosynthesis" EXACT [] synonym: "reduced NAD biosynthetic process" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthesis" EXACT [] synonym: "reduced nicotinamide adenine dinucleotide biosynthetic process" EXACT [] is_a: GO:0019359 ! nicotinamide nucleotide biosynthetic process is_a: GO:0019674 ! NAD metabolic process [Term] id: GO:0009436 name: glyoxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of glyoxylate, the anion of glyoxylic acid, HOC-COOH." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glyoxylate breakdown" EXACT [] synonym: "glyoxylate catabolism" EXACT [] synonym: "glyoxylate degradation" EXACT [] xref: MetaCyc:GLYOXDEG-PWY is_a: GO:0046185 ! aldehyde catabolic process is_a: GO:0046395 ! carboxylic acid catabolic process is_a: GO:0046487 ! glyoxylate metabolic process [Term] id: GO:0009437 name: carnitine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "carnitine metabolism" EXACT [] synonym: "vitamin Bt metabolic process" EXACT [] synonym: "vitamin Bt metabolism" EXACT [] is_a: GO:0006577 ! betaine metabolic process is_a: GO:0006767 ! water-soluble vitamin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009438 name: methylglyoxal metabolic process namespace: biological_process def: "The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid." [GOC:ai, http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "methylglyoxal bypass" NARROW [] synonym: "methylglyoxal metabolism" EXACT [] synonym: "methylglyoxal pathway" NARROW [] xref: MetaCyc:METHGLYUT-PWY is_a: GO:0006081 ! cellular aldehyde metabolic process [Term] id: GO:0009439 name: cyanate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanate metabolism" EXACT [] xref: MetaCyc:CYANCAT-PWY is_a: GO:0006082 ! organic acid metabolic process is_a: GO:0034641 ! cellular nitrogen compound metabolic process [Term] id: GO:0009440 name: cyanate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyanate, NCO-, the anion of cyanic acid." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "cyanate breakdown" EXACT [] synonym: "cyanate catabolism" EXACT [] synonym: "cyanate degradation" EXACT [] is_a: GO:0009439 ! cyanate metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0009441 name: glycolate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glycolate, the anion of hydroxyethanoic acid (glycolic acid)." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "glycolate metabolism" EXACT [] xref: MetaCyc:GLYCOLATEMET-PWY is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009442 name: allantoin assimilation pathway namespace: biological_process def: "The pathways by which allantoin is processed and converted to ureidoglycolate, and then into metabolically useful substrates. E. coli are able to utilize allantoin as a sole nitrogen source under anaerobic conditions by converting it to ureidoglycolate; this may be further metabolized to produce glyoxylate and thence 3-phosphoglycerate, or alternatively oxidized to oxolureate, which can converted into oxamate and carbamoylphosphate. This may then be further metabolized to CO2, NH4+ and ATP." [MetaCyc:PWY0-41] subset: gosubset_prok synonym: "allantoin catabolic process via ureidoglycolate" EXACT [] synonym: "allantoin catabolism via ureidoglycolate" EXACT [] synonym: "allantoin degradation pathway" RELATED [] xref: MetaCyc:PWY0-41 is_a: GO:0000256 ! allantoin catabolic process [Term] id: GO:0009443 name: pyridoxal 5'-phosphate salvage namespace: biological_process def: "Any process that generates pyridoxal 5'-phosphate, the active form of vitamin B6, from derivatives of it without de novo synthesis." [GOC:jl] subset: gosubset_prok synonym: "pyridoxal 5' phosphate salvage" EXACT [] xref: MetaCyc:PLPSAL-PWY is_a: GO:0008615 ! pyridoxine biosynthetic process is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009444 name: pyruvate oxidation namespace: biological_process def: "The chemical reactions and pathways resulting in the conversion of pyruvate to acetylphosphate." [MetaCyc:PYRUVOX-PWY] subset: gosubset_prok xref: MetaCyc:PYRUVOX-PWY xref: Wikipedia:Pyruvate_decarboxylation is_a: GO:0006090 ! pyruvate metabolic process [Term] id: GO:0009445 name: putrescine metabolic process namespace: biological_process def: "The chemical reactions and pathways involving putrescine, 1,4-diaminobutane; putrescine can be formed by decarboxylation of ornithine and is the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok synonym: "putrescine metabolism" EXACT [] is_a: GO:0006595 ! polyamine metabolic process [Term] id: GO:0009446 name: putrescine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of putrescine, 1,4-diaminobutane; putrescine can be synthesized from arginine or ornithine and is the metabolic precursor of spermidine and spermine." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "putrescine anabolism" EXACT [] synonym: "putrescine biosynthesis" EXACT [] synonym: "putrescine formation" EXACT [] synonym: "putrescine synthesis" EXACT [] is_a: GO:0006596 ! polyamine biosynthetic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009447 name: putrescine catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of putrescine, 1,4-diaminobutane; putrescine is the metabolic precursor of spermidine and spermine." [GOC:ai] subset: gosubset_prok synonym: "putrescine breakdown" EXACT [] synonym: "putrescine catabolism" EXACT [] synonym: "putrescine degradation" EXACT [] is_a: GO:0006598 ! polyamine catabolic process is_a: GO:0009445 ! putrescine metabolic process [Term] id: GO:0009448 name: gamma-aminobutyric acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: See also the biological process term 'neurotransmitter metabolic process ; GO:0042133'. subset: gosubset_prok synonym: "4-aminobutanoate metabolic process" EXACT [] synonym: "4-aminobutanoate metabolism" EXACT [] synonym: "4-aminobutyrate metabolic process" EXACT [] synonym: "4-aminobutyrate metabolism" EXACT [] synonym: "GABA metabolic process" EXACT [] synonym: "GABA metabolism" EXACT [] synonym: "gamma-aminobutyric acid metabolism" EXACT [] is_a: GO:0006575 ! cellular amino acid derivative metabolic process is_a: GO:0009308 ! amine metabolic process [Term] id: GO:0009449 name: gamma-aminobutyric acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter biosynthetic process ; GO:0042136'. synonym: "4-aminobutanoate biosynthesis" EXACT [] synonym: "4-aminobutanoate biosynthetic process" EXACT [] synonym: "4-aminobutyrate biosynthesis" EXACT [] synonym: "4-aminobutyrate biosynthetic process" EXACT [] synonym: "GABA biosynthesis" EXACT [] synonym: "GABA biosynthetic process" EXACT [] synonym: "gamma-aminobutyric acid anabolism" EXACT [] synonym: "gamma-aminobutyric acid biosynthesis" EXACT [] synonym: "gamma-aminobutyric acid formation" EXACT [] synonym: "gamma-aminobutyric acid synthesis" EXACT [] is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process [Term] id: GO:0009450 name: gamma-aminobutyric acid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms." [GOC:ai] comment: See also the biological process term 'neurotransmitter catabolic process ; GO:0042135'. subset: gosubset_prok synonym: "4-aminobutanoate catabolic process" EXACT [] synonym: "4-aminobutanoate catabolism" EXACT [] synonym: "4-aminobutyrate catabolic process" EXACT [] synonym: "4-aminobutyrate catabolism" EXACT [] synonym: "GABA catabolic process" EXACT [] synonym: "GABA catabolism" EXACT [] synonym: "gamma-aminobutyric acid breakdown" EXACT [] synonym: "gamma-aminobutyric acid catabolism" EXACT [] synonym: "gamma-aminobutyric acid degradation" EXACT [] xref: MetaCyc:4AMINOBUTMETAB-PWY is_a: GO:0009448 ! gamma-aminobutyric acid metabolic process is_a: GO:0042219 ! cellular amino acid derivative catabolic process [Term] id: GO:0009451 name: RNA modification namespace: biological_process alt_id: GO:0016547 def: "The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically." [GOC:go_curators, ISBN:1555811337 "Modification and Editing of RNA"] comment: The term 'RNA editing' (GO:0016547) was merged into 'RNA modification' (GO:0009451) on the basis of statements in the preface of Modification and Editing of RNA (ISBN:1555811337) that there is no clear distinction between modification and editing. subset: gosubset_prok synonym: "RNA editing" NARROW [GOC:hjd] xref: Wikipedia:RNA_editing is_a: GO:0016070 ! RNA metabolic process is_a: GO:0043412 ! macromolecule modification [Term] id: GO:0009452 name: RNA capping namespace: biological_process def: "The sequence of enzymatic reactions by which the 5' cap structure, an inverted 7-methylguanosine linked via a 5'-5' triphosphate bridge (m7G(5')ppp(5')X) to the first transcribed residue, is added to a nascent RNA polymerase II transcript." [PMID:9266685] is_a: GO:0006396 ! RNA processing [Term] id: GO:0009453 name: energy taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to physical parameters involved in energy generation, such as light, oxygen, and oxidizable substrates." [GOC:jl, PMID:11029423] subset: gosubset_prok synonym: "energytaxis" EXACT [] synonym: "taxis in response to energy source" EXACT [] is_a: GO:0042330 ! taxis [Term] id: GO:0009454 name: aerotaxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to environmental oxygen." [GOC:jl, ISBN:0192801023] subset: gosubset_prok synonym: "taxis in response to atmospheric oxygen" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis [Term] id: GO:0009455 name: redox taxis namespace: biological_process def: "The directed movement of a motile cell or organism in response to redox potential." [GOC:jl, PMID:11029423] synonym: "redoxtaxis" EXACT [] synonym: "taxis in response to redox potential" EXACT [] synonym: "taxis in response to redox stimulus" EXACT [] is_a: GO:0006935 ! chemotaxis is_a: GO:0009453 ! energy taxis is_a: GO:0051775 ! response to redox state [Term] id: GO:0009457 name: flavodoxin namespace: molecular_function def: "OBSOLETE. A group of small electron carriers, characteristic of anaerobic bacteria, photosynthetic bacteria, cyanobacteria and eukaryotic algae. Contain flavin mononucleotide." [GOC:kd] comment: This term was made obsolete because it represents a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009458 name: cytochrome namespace: molecular_function def: "OBSOLETE. A hemeprotein whose characteristic mode of action involves transfer of reducing equivalents associated with a reversible change in oxidation state of the prosthetic group. This redox change involves a single electron, reversible equilibrium between the Fe(II) and Fe(III) states of the central iron atom." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0045153 consider: GO:0045154 consider: GO:0045155 consider: GO:0045156 consider: GO:0045157 consider: GO:0045158 [Term] id: GO:0009459 name: cytochrome a namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme a." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045154 [Term] id: GO:0009460 name: cytochrome b namespace: molecular_function def: "OBSOLETE. A cytochrome containing noncovalently bound protoheme (iron protoporphyrin IX; heme b)." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009461 name: cytochrome c namespace: molecular_function def: "OBSOLETE. A cytochrome containing heme bound to the protein by one or, more (commonly two) thioether bonds involving sulfhydryl groups of cysteine residues." [GOC:kd] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045155 [Term] id: GO:0009462 name: cytochrome d namespace: molecular_function def: "OBSOLETE. A cytochrome in which the prosthetic group is a tetrapyrrolic chelate of iron in which the degree of conjugation of double bonds is less than in porphyrin. This definition would appear to include siroheme proteins (e.g. nitrite and sulfite reductases), but these are not cytochromes." [GOC:kd, PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009463 name: cytochrome b/b6 namespace: molecular_function def: "OBSOLETE. Diheme cytochrome b; cytochrome b has the hemes b(562) and b(566) and is a component of the mitochondrial respiratory chain complex III. Cytochrome b6 is a component of bc complex acting between photosystems II and I of photosynthesis." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009464 name: cytochrome b5 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009465 name: soluble cytochrome b562 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009466 name: class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009467 name: monoheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009468 name: diheme class I cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009469 name: class II cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009470 name: class IIa cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009471 name: class III cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009472 name: cytochrome c3 (tetraheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009473 name: cytochrome c7 (triheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009474 name: nonaheme cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009475 name: high-molecular-weight cytochrome c (hexadecaheme) namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009476 name: class IV cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009477 name: cytochrome c1 namespace: molecular_function def: "OBSOLETE. A cytochrome c that is an integral component of the mitochondrial respiratory complex III. Functions as an electron donor to cytochrome c." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045153 [Term] id: GO:0009478 name: cytochrome c554 namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009479 name: cytochrome f namespace: molecular_function def: "OBSOLETE. A cytochrome c that is characteristic of green plants and transfers electrons to plastocyanin." [PMID:1655423] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0045158 [Term] id: GO:0009480 name: class IIb cytochrome c namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it represents a gene product. is_obsolete: true consider: GO:0009055 [Term] id: GO:0009481 name: aa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009482 name: ba3-type cytochrome c oxidase namespace: molecular_function alt_id: GO:0009484 def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009483 name: caa3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009485 name: cbb3-type cytochrome c oxidase namespace: molecular_function def: "OBSOLETE. Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: 4 ferrocytochrome c + O2 = 4 ferricytochrome c + 2 H2O." [EC:1.9.3.1] comment: This term was made obsolete because it describes a class of gene products rather than a molecular function. is_obsolete: true replaced_by: GO:0004129 [Term] id: GO:0009486 name: cytochrome bo3 ubiquinol oxidase activity namespace: molecular_function xref: EC:1.10.3.- is_a: GO:0008827 ! cytochrome o ubiquinol oxidase activity [Term] id: GO:0009487 name: glutaredoxin namespace: molecular_function def: "OBSOLETE. A small disulfide-containing redox protein that serves as a glutathione-disulfide oxidoreductase." [GOC:kd] comment: This term was made obsolete because it represent a gene product. is_obsolete: true consider: GO:0006467 consider: GO:0015036 consider: GO:0015038 [Term] id: GO:0009488 name: amicyanin namespace: molecular_function def: "OBSOLETE. A copper-containing protein that acts as an electron carrier between methylamine dehydrogenase and cytochrome c." [PMID:1655423] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009489 name: rubredoxin namespace: molecular_function def: "OBSOLETE. A low molecular weight mononuclear iron protein involved in electron transfer, with an iron tetrahedrally coordinated by the sulfurs of four conserved cysteine residues." [GOC:kd] comment: This term was made obsolete because it does not represent a molecular function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009490 name: mononuclear iron electron carrier namespace: molecular_function def: "OBSOLETE. A mononuclear iron entity that serves as an electron acceptor and electron donor in an electron transport system." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009491 name: redox-active disulfide bond electron carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. synonym: "redox-active disulphide bond electron carrier" EXACT [] is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009492 name: 2Fe-2S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009493 name: adrenodoxin-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009494 name: chloroplast-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009495 name: thioredoxin-like 2Fe-2S ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009496 name: plastoquinol-plastocyanin reductase activity namespace: molecular_function def: "Catalysis of the reaction: plastoquinol-1 + 2 oxidized plastocyanin = plastoquinone + 2 reduced plastocyanin." [EC:1.10.99.1] subset: gosubset_prok synonym: "cytochrome b6f" NARROW [EC:1.10.99.1] synonym: "plastoquinol/plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] synonym: "plastoquinol:oxidized-plastocyanin oxidoreductase activity" EXACT [EC:1.10.99.1] xref: EC:1.10.99.1 xref: MetaCyc:PLASTOQUINOL--PLASTOCYANIN-REDUCTASE-RXN is_a: GO:0016679 ! oxidoreductase activity, acting on diphenols and related substances as donors [Term] id: GO:0009497 name: 3Fe-4S/4Fe-4S electron transfer carrier namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it refers to a class of gene products. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009498 name: bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009499 name: monocluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009500 name: dicluster bacterial-type ferredoxin namespace: molecular_function def: "OBSOLETE (was not defined before being made obsolete)." [GOC:ai] comment: This term was made obsolete because it does not represent a function. is_obsolete: true replaced_by: GO:0009055 [Term] id: GO:0009501 name: amyloplast namespace: cellular_component def: "A plastid whose main function is to synthesize and store starch." [ISBN:0140514031] xref: Wikipedia:Amyloplast is_a: GO:0009536 ! plastid [Term] id: GO:0009502 name: photosynthetic electron transport chain namespace: cellular_component def: "OBSOLETE. A series of membrane-linked oxidation-reduction reactions in which electrons are transferred from an initial electron donor through a series of intermediates to a final electron acceptor (usually oxygen)." [GOC:mtg_electron_transport, ISBN:014051403] comment: This term was made obsolete because it represents a process. is_obsolete: true consider: GO:0009767 [Term] id: GO:0009503 name: thylakoid light-harvesting complex namespace: cellular_component def: "A thylakoid membrane complex of chlorophylls a and b together with chlorophyll a-b binding proteins. In addition, LHCs contain a number of other proteins, the function of which is speculative, together with accessory pigments. The LHCs capture and transfer energy to photosystems I and II. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0198547684] is_a: GO:0030076 ! light-harvesting complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0009504 name: cell plate namespace: cellular_component def: "The nascent cell membrane and cell wall structure that forms between two daughter nuclei near the center of a dividing plant cell. It develops at the equitorial region of the phragmoplast. It grows outwards to join with the lateral walls and form two daughter cells." [ISBN:0198547684] xref: Wikipedia:Cell_plate is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009505 name: plant-type cell wall namespace: cellular_component def: "A more or less rigid stucture lying outside the cell membrane of a cell and composed of cellulose and pectin and other organic and inorganic substances." [ISBN:0471245208] synonym: "cellulose and pectin-containing cell wall" EXACT [] is_a: GO:0005618 ! cell wall [Term] id: GO:0009506 name: plasmodesma namespace: cellular_component def: "A fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "plasmodesmata" EXACT [] xref: Wikipedia:Plasmodesma is_a: GO:0005911 ! cell-cell junction relationship: part_of GO:0055044 ! symplast [Term] id: GO:0009507 name: chloroplast namespace: cellular_component def: "A chlorophyll-containing plastid with thylakoids organized into grana and frets, or stroma thylakoids, and embedded in a stroma." [ISBN:0471245208] xref: Wikipedia:Chloroplast is_a: GO:0009536 ! plastid [Term] id: GO:0009508 name: plastid chromosome namespace: cellular_component def: "A circular DNA molecule containing plastid encoded genes." [ISBN:0943883999] is_a: GO:0000229 ! cytoplasmic chromosome is_a: GO:0044435 ! plastid part intersection_of: GO:0005694 ! chromosome intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0042646 ! plastid nucleoid [Term] id: GO:0009509 name: chromoplast namespace: cellular_component def: "A plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [ISBN:0471245208] xref: Wikipedia:Chromoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009510 name: plasmodesmatal desmotubule namespace: cellular_component alt_id: GO:0009572 def: "A tightly wound cylinder of membrane that is located within the plasmodesmal pore and runs the length of the plasmodesma. The desmotubule likely provides a rigid stability to plasmodesmata and confers a fixed diameter and pore size to the plasmodesmal canal, and is linked to the endoplasmic reticulum in each of the adjacent cell." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "desmotubule central rod" RELATED [] is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009511 name: plasmodesmatal endoplasmic reticulum namespace: cellular_component def: "Endoplasmic reticulum found in plasmodesmata, junctions connecting the cytoplasm of adjacent plant cells." [GOC:ai] synonym: "plasmodesmatal ER" EXACT [] is_a: GO:0005783 ! endoplasmic reticulum is_a: GO:0044432 ! endoplasmic reticulum part is_a: GO:0044459 ! plasma membrane part is_a: GO:0071212 ! subsynaptic reticulum relationship: part_of GO:0009510 ! plasmodesmatal desmotubule [Term] id: GO:0009512 name: cytochrome b6f complex namespace: cellular_component def: "Complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen. The complex contains a core structure of three catalytic subunits: cytochrome b, the Rieske iron sulfur protein (ISP), and cytochrome f, which are arranged in an integral membrane-bound dimeric complex; additional subunits are present, and vary among different species." [ISBN:0943883999, PMID:16228398, PMID:16352458] subset: gosubset_prok synonym: "cyt b(6)f complex" EXACT [] synonym: "cyt b6-f complex" EXACT [] synonym: "cyt b6/f complex" EXACT [] synonym: "cyt b6f complex" EXACT [] synonym: "cytochrome b(6)f complex" EXACT [] synonym: "cytochrome b6-f complex" EXACT [] synonym: "cytochrome b6/f complex" EXACT [] xref: Wikipedia:Cytochrome_b6f_complex is_a: GO:0043234 ! protein complex is_a: GO:0044436 ! thylakoid part [Term] id: GO:0009513 name: etioplast namespace: cellular_component def: "A plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [ISBN:0943883999] xref: Wikipedia:Etioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009514 name: glyoxysome namespace: cellular_component def: "A specialized form of peroxisome that contains the enzymes of the glyoxylate pathway. The glyoxysome is found in some plant cells, notably the cells of germinating seeds." [GOC:dhl, ISBN:0140514031] xref: Wikipedia:Glyoxysome is_a: GO:0005777 ! peroxisome [Term] id: GO:0009515 name: granal stacked thylakoid namespace: cellular_component def: "Appressed thylakoid membranes that are part of a granum (stacked regions). A characteristic of these appressed regions is the preferential localization of photosystem II." [GOC:lr] synonym: "chloroplast stacked thylakoid" EXACT [] is_a: GO:0009534 ! chloroplast thylakoid intersection_of: GO:0009534 ! chloroplast thylakoid intersection_of: part_of GO:0009542 ! granum relationship: part_of GO:0009542 ! granum [Term] id: GO:0009516 name: leucoplast namespace: cellular_component def: "A colorless plastid involved in the synthesis of monoterpenes." [ISBN:0943883999] xref: Wikipedia:Leucoplast is_a: GO:0009536 ! plastid [Term] id: GO:0009517 name: PSII associated light-harvesting complex II namespace: cellular_component def: "Protein-pigment complex associated with photosystem II." [GOC:lr, ISBN:0582227089] synonym: "LHCII" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009518 name: PSI associated light-harvesting complex I namespace: cellular_component def: "Protein-pigment complex associated with photosystem I." [GOC:lr] synonym: "LHCI" EXACT [] is_a: GO:0009503 ! thylakoid light-harvesting complex [Term] id: GO:0009519 name: middle lamella namespace: cellular_component def: "Layer of intercellular material, chiefly pectic substances, cementing together the primary walls of contiguous cells." [ISBN:0471245208] xref: Wikipedia:Middle_lamella is_a: GO:0044421 ! extracellular region part relationship: part_of GO:0005615 ! extracellular space [Term] id: GO:0009521 name: photosystem namespace: cellular_component alt_id: GO:0030090 def: "A complex located in a photosynthetic membrane that consists of a photoreaction center associated with accessory pigments and electron carriers. Examples of this component are found in Arabidopsis thaliana and in photosynthetic bacterial and archaeal species." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: goslim_pir subset: gosubset_prok synonym: "reaction center" NARROW [] synonym: "reaction centre" NARROW [] xref: Wikipedia:Photosystem is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0034357 ! photosynthetic membrane [Term] id: GO:0009522 name: photosystem I namespace: cellular_component def: "A photosystem that contains an iron-sulfur reaction center associated with accessory pigments and electron carriers. In cyanobacteria and chloroplasts, photosystem I functions as a light-dependent plastocyanin-ferredoxin oxidoreductase, transferring electrons from plastocyanin to ferredoxin; in photosynthetic bacteria that have only a single type I photosystem, such as the green sulfur bacteria, electrons can go either to ferredoxin (Fd) -> NAD+ or to menaquinone (MK) -> Cytb/FeS -> Cytc555 -> photosystem I (cyclic photophosphorylation)." [GOC:ds, GOC:mah, ISBN:0140514031, PMID:9821949] subset: gosubset_prok is_a: GO:0009521 ! photosystem [Term] id: GO:0009523 name: photosystem II namespace: cellular_component def: "A photosystem that contains a pheophytin-quinone reaction center with associated accessory pigments and electron carriers. In cyanobacteria and chloroplasts, in the presence of light, PSII functions as a water-plastoquinone oxidoreductase, transferring electrons from water to plastoquinone, whereas other photosynthetic bacteria carry out anoxygenic photosynthesis and oxidize other compounds to re-reduce the photoreaction center." [GOC:ds, GOC:mah, ISBN:0943088399, PMID:9821949] subset: gosubset_prok xref: Wikipedia:Photosystem_II is_a: GO:0009521 ! photosystem [Term] id: GO:0009524 name: phragmoplast namespace: cellular_component def: "Fibrous structure (light microscope view) that arises between the daughter nuclei at telophase and within which the initial partition (cell plate), dividing the mother cell in two (cytokinesis), is formed. Appears at first as a spindle connected to the two nuclei, but later spreads laterally in the form of a ring. Consists of microtubules." [ISBN:0471245208] xref: Wikipedia:Phragmoplast is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009525 name: phragmosome namespace: cellular_component def: "A flattened membranous vesicle containing cell wall components." [ISBN:0943883999] xref: Wikipedia:Phragmosome is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009526 name: plastid envelope namespace: cellular_component def: "The double lipid bilayer enclosing a plastid and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:jy] is_a: GO:0031967 ! organelle envelope is_a: GO:0044435 ! plastid part [Term] id: GO:0009527 name: plastid outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the plastid envelope." [GOC:lr] is_a: GO:0031968 ! organelle outer membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009528 name: plastid inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the plastid envelope; also faces the plastid stroma." [GOC:lr] is_a: GO:0019866 ! organelle inner membrane is_a: GO:0042170 ! plastid membrane [Term] id: GO:0009529 name: plastid intermembrane space namespace: cellular_component def: "The region between the inner and outer lipid bilayers of the plastid envelope." [GOC:lr] synonym: "plastid envelope lumen" EXACT [] is_a: GO:0031970 ! organelle envelope lumen is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0009530 name: primary cell wall namespace: cellular_component def: "A plant cell wall that is still able to expand, permitting cell growth. Primary cell walls contain more pectin than secondary walls and no lignin is present." [GOC:jid, http://cancerweb.ncl.ac.uk] is_a: GO:0009505 ! plant-type cell wall is_a: GO:0048196 ! middle lamella-containing extracellular matrix [Term] id: GO:0009531 name: secondary cell wall namespace: cellular_component def: "A plant cell wall that is no longer able to expand and so does not permit growth. Secondary cell walls contain less pectin that primary cell walls. The secondary cell is mostly composed of cellulose and is strengthened with lignin." [GOC:jid, http://cancerweb.ncl.ac.uk] xref: Wikipedia:Secondary_cell_wall is_a: GO:0009505 ! plant-type cell wall is_a: GO:0048196 ! middle lamella-containing extracellular matrix [Term] id: GO:0009532 name: plastid stroma namespace: cellular_component def: "The proteinaceous ground substance of plastids." [ISBN:047142520] is_a: GO:0044435 ! plastid part [Term] id: GO:0009533 name: chloroplast stromal thylakoid namespace: cellular_component def: "Unstacked thylakoids that connect the grana stacks through the stroma." [ISBN:0943883999] is_a: GO:0009534 ! chloroplast thylakoid intersection_of: GO:0009534 ! chloroplast thylakoid intersection_of: part_of GO:0009570 ! chloroplast stroma relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009534 name: chloroplast thylakoid namespace: cellular_component def: "Sac-like membranous structures (cisternae) in a chloroplast combined into stacks (grana) and present singly in the stroma (stroma thylakoids or frets) as interconnections between grana. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0943883999] is_a: GO:0031976 ! plastid thylakoid is_a: GO:0044434 ! chloroplast part intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0009535 name: chloroplast thylakoid membrane namespace: cellular_component def: "The pigmented membrane of a chloroplast thylakoid. An example of this component is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] is_a: GO:0044434 ! chloroplast part is_a: GO:0055035 ! plastid thylakoid membrane relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009536 name: plastid namespace: cellular_component def: "Any member of a family of organelles found in the cytoplasm of plants and some protists, which are membrane-bounded and contain DNA. Plant plastids develop from a common type, the proplastid." [GOC:jl, ISBN:0198547684] subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok xref: Wikipedia:Plastid is_a: GO:0043231 ! intracellular membrane-bounded organelle is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0009537 name: proplastid namespace: cellular_component def: "The precursor of other plastids." [ISBN:0943883999] is_a: GO:0009536 ! plastid [Term] id: GO:0009538 name: photosystem I reaction center namespace: cellular_component def: "A photochemical system containing P700, the chlorophyll a dimer that functions as a primary electron donor. Functioning as a light-dependent plastocyanin-ferredoxin oxidoreductase, it transfers electrons from plastocyanin to ferredoxin." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem I reaction centre" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009539 name: photosystem II reaction center namespace: cellular_component def: "An integral membrane complex containing P680, the chlorophyll a molecule that functions as a primary electron donor. In the light, functioning as a water-plastoquinone oxidoreductase, it transfers electrons from water to plastoquinone." [GOC:kd, ISBN:0943088399] subset: gosubset_prok synonym: "photosystem II reaction centre" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009540 name: zeaxanthin epoxidase activity namespace: molecular_function def: "Catalysis of the reactions: zeaxanthin + NAD(P)H + H+ + O2 = antheraxanthin + NAD(P)+ + H2O and antheraxanthin + NAD(P)H + H+ + O2 = violaxanthin + NAD(P)+ + H2O." [EC:1.14.13.90] synonym: "zea-epoxidase activity" EXACT [EC:1.14.13.90] synonym: "zeaxanthin,NAD(P)H:oxygen oxidoreductase activity" EXACT [EC:1.14.13.90] xref: EC:1.14.13.90 is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0009541 name: etioplast prolamellar body namespace: cellular_component def: "A three dimensional regular lattice found in etioplasts. It is composed of a continuous system of tubules but when exposed to light the symmetrical arrangement is rapidly lost as tubules become pinched off into two dimensional sections of lattice. These for perforated sheets of membrane that move apart, extend and increase, finally establishing the typical granal and intergranal lamellae of the mature chloroplast." [ISBN:0140514031] is_a: GO:0044435 ! plastid part relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009542 name: granum namespace: cellular_component def: "Distinct stack of lamellae seen within chloroplasts. Grana contain the pigments, electron transfer compounds, and enzymes essential to the light-dependent reactions of photosynthesis." [ISBN:014051403] is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009543 name: chloroplast thylakoid lumen namespace: cellular_component def: "The cavity enclosed within the chloroplast thylakoid membrane. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:006501037] is_a: GO:0031978 ! plastid thylakoid lumen is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009534 ! chloroplast thylakoid [Term] id: GO:0009544 name: chloroplast ATP synthase complex namespace: cellular_component def: "The protein complex that catalyzes the phosphorylation of ADP to ATP in chloroplasts." [ISBN:019854768] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009535 ! chloroplast thylakoid membrane [Term] id: GO:0009545 name: elaioplast namespace: cellular_component def: "A leucoplast in which oil is stored." [ISBN:0140514031] xref: Wikipedia:Elaioplast is_a: GO:0009536 ! plastid [Term] id: GO:0009546 name: plasmodesmatal cytoplasmic sleeve namespace: cellular_component def: "The space between the plasma membrane and the desmotubule of a plasmodesma." [http://biology.kenyon.edu/edwards/project/greg/pd.htm] synonym: "plasmodesmatal cytoplasmic annulus" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009547 name: plastid ribosome namespace: cellular_component def: "A ribosome contained within a plastid." [GOC:tair_curators] is_a: GO:0000313 ! organellar ribosome is_a: GO:0044435 ! plastid part intersection_of: GO:0005840 ! ribosome intersection_of: part_of GO:0009536 ! plastid relationship: part_of GO:0009532 ! plastid stroma [Term] id: GO:0009548 name: plasmodesmatal plasma membrane namespace: cellular_component def: "The portion of the plasma membrane surrounding a plasmodesma." [GOC:mah] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009506 ! plasmodesma [Term] id: GO:0009549 name: cellulose microfibril namespace: cellular_component def: "Cellulose is a straight chain polysaccharide composed of B(14) linked glucose subunits. It is a major component of plant cell walls where it is found as microfibrils laid down in orthogonal layers. Higher plant microfibrils are about 10nm in diameter and extremely long in relation to their width. The cellulose molecules are oriented parallel to the long axis of the microfibril in a paracrystalline array, which provides great tensile strength. The microfibrils are held in place by the wall matrix and their orientation is closely controlled by the cell." [GOC:jid, http://cancerweb.ncl.ac.uk, ISBN:0943088399] is_a: GO:0001527 ! microfibril is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009530 ! primary cell wall relationship: part_of GO:0009531 ! secondary cell wall [Term] id: GO:0009550 name: primary plasmodesma namespace: cellular_component def: "A plasmodesma that consists of a simple, single channel; found predominantly in young tissue and formed as a function of cell plate formation during cytokinesis." [PMID:15012255] synonym: "simple plasmodesma" EXACT [] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009551 name: secondary plasmodesma namespace: cellular_component def: "A plasmodesma with a branched structure, often with many channels leading into a larger central cavity; found in older tissues and usually derived from preexisting primary plasmodesmata." [PMID:15012255] is_a: GO:0009506 ! plasmodesma [Term] id: GO:0009553 name: embryo sac development namespace: biological_process alt_id: GO:0048230 def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation to the mature structure. The process begins with the meiosis of the megasporocyte to form four haploid megaspores. Three of the megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. The two polar nuclei fuse resulting in a mononucleate diploid endosperm mother cell. The three antipodal cells degenerate." [GOC:mtg_plant, GOC:tb] synonym: "female gametophyte development" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009554 name: megasporogenesis namespace: biological_process def: "The process by which the megasporocyte undergoes meiosis, giving rise to four haploid megaspores in the nucellus." [GOC:mtg_plant, GOC:tb] synonym: "megaspore development" EXACT [] synonym: "megaspore mother cell meiosis" EXACT [] synonym: "meiosis of the megasporocyte" EXACT [] synonym: "meiotic division of the megasporocyte" EXACT [] is_a: GO:0048236 ! plant-type spore development relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009555 name: pollen development namespace: biological_process alt_id: GO:0009564 alt_id: GO:0048231 def: "The process whose specific outcome is the progression of the pollen grain over time, from its formation to the mature structure. The process begins with the meiosis of the microsporocyte to form four haploid microspores. The nucleus of each microspore then divides by mitosis to form a two-celled organism, the pollen grain, that contains a tube cell as well as a smaller generative cell. The pollen grain is surrounded by an elaborate cell wall. In some species, the generative cell immediately divides again to give a pair of sperm cells. In most flowering plants, however this division takes place later, in the tube that develops when a pollen grain germinates." [GOC:mtg_plant, GOC:mtg_sensu, GOC:tb] synonym: "formation of generative and vegetative cells" EXACT [] synonym: "male gametophyte development" EXACT [] synonym: "male gametophyte formation" EXACT [] synonym: "microgametophyte development" EXACT [] synonym: "pollen grain formation" EXACT [] is_a: GO:0048229 ! gametophyte development [Term] id: GO:0009556 name: microsporogenesis namespace: biological_process def: "The process by which the microsporocyte undergoes meiosis, giving rise to four haploid microspores." [GOC:mtg_plant, GOC:tb] synonym: "microspore development" EXACT systematic_synonym [] is_a: GO:0048236 ! plant-type spore development relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0009557 name: antipodal cell differentiation namespace: biological_process def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of an antipodal cell." [GOC:jid, GOC:mtg_plant] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009558 name: cellularization of the embryo sac namespace: biological_process alt_id: GO:0009797 def: "The process by which the eight-nucleate single celled female gametophyte develops into the seven-celled female gametophyte. This mature structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu, ISBN:047186840X] synonym: "cellularization" BROAD [] synonym: "cellularization of megagametophyte" EXACT [] synonym: "cellularization of the female gametophyte" EXACT [] is_a: GO:0007349 ! cellularization relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009559 name: embryo sac central cell differentiation namespace: biological_process def: "The process whereby the two uncellularized polar nuclei cellularize, fuse and acquire the specialized features of a mononucleate diploid central cell." [GOC:jid, GOC:mtg_plant] synonym: "embryo sac endosperm mother cell differentiation" EXACT [] synonym: "female gametophyte central cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009560 name: embryo sac egg cell differentiation namespace: biological_process alt_id: GO:0048233 def: "The process whereby an uncellularized embryo sac nucleus cellularizes and acquires the specialized features of an egg cell. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_plant, GOC:mtg_sensu] synonym: "female gamete generation" BROAD [] synonym: "female gametophyte egg cell differentiation" EXACT [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0007292 ! female gamete generation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009561 name: megagametogenesis namespace: biological_process def: "The process whose specific outcome is the progression of the embryo sac over time, from its formation as the megaspore to the mature structure. The process begins when three of the four haploid megaspores disintegrate, and the fourth undergoes mitosis giving rise to a binucleate syncytial embryo sac. The two haploid nuclei migrate to the opposite poles of the embryo sac and then undergo two rounds of mitosis generating four haploid nuclei at each pole. One nucleus from each set of four migrates to the center of the cell. Cellularization occurs, resulting in an eight-nucleate seven-celled structure. This structure contains two synergid cells and an egg cell at the micropylar end, and three antipodal cells at the other end. A binucleate endosperm mother cell is formed at the center." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac development from the megaspore" EXACT systematic_synonym [] synonym: "megagametophyte nucleus division" EXACT [] xref: Wikipedia:Megagametogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0009553 ! embryo sac development [Term] id: GO:0009562 name: embryo sac nuclear migration namespace: biological_process def: "The directed movement of an embryo sac nucleus to the pole or center of the cell." [GOC:jl, GOC:mtg_plant] synonym: "embryo sac nucleus migration" EXACT [] synonym: "female gametophyte nuclear migration" EXACT [] synonym: "female gametophyte nucleus migration" EXACT [] synonym: "megagametophyte nuclear migration" EXACT [] synonym: "megagametophyte nucleus migration" EXACT [] is_a: GO:0007097 ! nuclear migration relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009563 name: synergid differentiation namespace: biological_process def: "The process whereby an uncellularized nucleus cellularizes and acquires the specialized features of a synergid cell." [GOC:jid] synonym: "synergid cell differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0009561 ! megagametogenesis [Term] id: GO:0009566 name: fertilization namespace: biological_process def: "The union of gametes of opposite sexes during the process of sexual reproduction to form a zygote. It involves the fusion of the gametic nuclei (karyogamy) and cytoplasm (plasmogamy)." [GOC:tb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Fertilisation is_a: GO:0022414 ! reproductive process relationship: part_of GO:0019953 ! sexual reproduction [Term] id: GO:0009567 name: double fertilization forming a zygote and endosperm namespace: biological_process def: "Fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the two polar nuclei to form the 3n primary endosperm nucleus and then develops into the endosperm. The ploidy level of the 2n zygote and 3n primary endosperm nucleus is determined by the ploidy level of the parents involved. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "double fertilization" EXACT [] is_a: GO:0009566 ! fertilization [Term] id: GO:0009568 name: amyloplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in amyloplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, PMID:11217978] synonym: "amyloplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain intersection_of: GO:0043036 ! starch grain intersection_of: part_of GO:0009501 ! amyloplast relationship: part_of GO:0009501 ! amyloplast [Term] id: GO:0009569 name: chloroplast starch grain namespace: cellular_component def: "Plant storage body for amylose and amylopectin, 1-100um in diameter, and located in chloroplasts. Also contains small amounts of enzymes, amino acids, lipids and nucleic acids. The shape of the grain varies widely amongst species, but is often spherical or disk-shaped." [GOC:jl, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "chloroplast starch granule" EXACT [] is_a: GO:0043036 ! starch grain is_a: GO:0044434 ! chloroplast part intersection_of: GO:0043036 ! starch grain intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0009570 name: chloroplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chloroplast but excluding the thylakoid space. It contains DNA, ribosomes and some temporary products of photosynthesis." [ISBN:0198547684] is_a: GO:0009532 ! plastid stroma is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009571 name: proplastid stroma namespace: cellular_component def: "The space enclosed by the double membrane of a proplastid." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009537 ! proplastid [Term] id: GO:0009573 name: chloroplast ribulose bisphosphate carboxylase complex namespace: cellular_component def: "A complex, located in the chloroplast, containing either both large and small subunits or just small subunits which carries out the activity of producing 3-phosphoglycerate from carbon dioxide and ribulose-1,5-bisphosphate. An example of this component is found in Arabidopsis thaliana." [GOC:mlg, GOC:mtg_sensu] synonym: "chloroplast RubisCO complex" EXACT [] is_a: GO:0044434 ! chloroplast part is_a: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: GO:0048492 ! ribulose bisphosphate carboxylase complex intersection_of: part_of GO:0009507 ! chloroplast relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009574 name: preprophase band namespace: cellular_component def: "A dense band of microtubules, 1-3 pm wide, that appears just beneath the cell membrane before the start of cell division in the cells of higher plants. It precedes the onset of prophase and then disappears as mitosis begins, yet it somehow determines the plane of orientation of the new cell plate forming in late telophase and marks the zone of the parental cell wall where fusion with the growing cell plate ultimately occurs." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] xref: Wikipedia:Preprophase_band is_a: GO:0044430 ! cytoskeletal part is_a: GO:0044444 ! cytoplasmic part relationship: part_of GO:0015630 ! microtubule cytoskeleton [Term] id: GO:0009575 name: chromoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a chromoplast but excluding the photosynthetic material." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009509 ! chromoplast [Term] id: GO:0009576 name: leucoplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of a leucoplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009516 ! leucoplast [Term] id: GO:0009577 name: elaioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an elaioplast." [GOC:mah] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009545 ! elaioplast [Term] id: GO:0009578 name: etioplast stroma namespace: cellular_component def: "The space enclosed by the double membrane of an etioplast but excluding the prothylakoid space. It contains the etioplast DNA." [GOC:jl] is_a: GO:0009532 ! plastid stroma relationship: part_of GO:0009513 ! etioplast [Term] id: GO:0009579 name: thylakoid namespace: cellular_component def: "A membranous cellular structure that bears the photosynthetic pigments in plants, algae, and cyanobacteria. In cyanobacteria thylakoids are of various shapes and are attached to, or continuous with, the plasma membrane. In eukaryotes they are flattened, membrane-bounded disk-like structures located in the chloroplasts; in the chloroplasts of higher plants the thylakoids form dense stacks called grana. Isolated thylakoid preparations can carry out photosynthetic electron transport and the associated phosphorylation." [GOC:ds, GOC:mtg_sensu, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: A thylakoid is not considered an organelle, but some thylakoids are part of organelles. subset: goslim_generic subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "photosynthetic membrane" RELATED [] xref: Wikipedia:Thylakoid is_a: GO:0044424 ! intracellular part [Term] id: GO:0009580 name: thylakoid (sensu Bacteria) namespace: cellular_component def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because more specific children exist. is_obsolete: true consider: GO:0030075 consider: GO:0042716 [Term] id: GO:0009581 name: detection of external stimulus namespace: biological_process def: "The series of events in which an external stimulus is received by a cell and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of external stimulus" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009582 name: detection of abiotic stimulus namespace: biological_process def: "The series of events in which an (non-living) abiotic stimulus is received by a cell and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of abiotic stimulus" RELATED [] is_a: GO:0009628 ! response to abiotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009583 name: detection of light stimulus namespace: biological_process def: "The series of events in which a light stimulus (in the form of photons) is received and converted into a molecular signal." [GOC:go_curators] subset: gosubset_prok synonym: "detection of light" EXACT [] synonym: "perception of light" RELATED [] is_a: GO:0009416 ! response to light stimulus is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus [Term] id: GO:0009584 name: detection of visible light namespace: biological_process def: "The series of events in which a visible light stimulus is received by a cell and converted into a molecular signal. A visible light stimulus is electromagnetic radiation that can be perceived visually by an organism; for organisms lacking a visual system, this can be defined as light with a wavelength within the range 380 to 780 nm." [GOC:go_curators, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "perception of visible light" RELATED [] is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009585 name: red, far-red light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from red or far-red light into a molecular signal; the red, far-red light range is defined as having a wavelength within the range 660-730 nm." [GOC:mah] subset: gosubset_prok synonym: "phytochrome signaling pathway" BROAD [] synonym: "red-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction relationship: part_of GO:0010017 ! red or far-red light signaling pathway [Term] id: GO:0009586 name: rhodopsin mediated phototransduction namespace: biological_process def: "The series of molecular signals generated as a consequence of excitation of rhodopsin by a photon and the events then required to return the rhodopsin containing cell to the unexcited state." [GOC:hb] is_a: GO:0007603 ! phototransduction, visible light is_a: GO:0050908 ! detection of light stimulus involved in visual perception [Term] id: GO:0009587 name: phototrophin mediated phototransduction namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] is_obsolete: true replaced_by: GO:0007602 [Term] id: GO:0009588 name: UV-A, blue light phototransduction namespace: biological_process def: "The sequence of reactions within a cell required to convert absorbed photons from UV-A or blue light into a molecular signal; the UV-A, blue light range is defined as having a wavelength within the range of approximately 400-500 nm." [GOC:mah] synonym: "blue-sensitive opsin" RELATED [] synonym: "short-wave-sensitive opsin" RELATED [] synonym: "violet-sensitive opsin" RELATED [] is_a: GO:0007602 ! phototransduction [Term] id: GO:0009589 name: detection of UV namespace: biological_process def: "The series of events in which an ultraviolet radiation (UV light) stimulus is received by a cell and converted into a molecular signal. Ultraviolet radiation is electromagnetic radiation with a wavelength in the range of 10 to 380 nanometers." [GOC:go_curators, GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of ultraviolet light stimulus" EXACT [] synonym: "detection of ultraviolet radiation stimulus" EXACT [] synonym: "detection of UV light stimulus" EXACT [] synonym: "detection of UV radiation stimulus" EXACT [] synonym: "perception of UV" RELATED [] is_a: GO:0009411 ! response to UV is_a: GO:0009583 ! detection of light stimulus [Term] id: GO:0009590 name: detection of gravity namespace: biological_process def: "The series of events in which a gravitational stimulus is received by a cell and converted into a molecular signal." [GOC:hb] synonym: "perception of gravity" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009582 ! detection of abiotic stimulus is_a: GO:0009629 ! response to gravity [Term] id: GO:0009591 name: perception of mechanical stimulus namespace: biological_process alt_id: GO:0007609 def: "OBSOLETE. The series of events by which a mechanical stimulus is received by a cell and converted into a molecular signal." [GOC:hb] comment: This term was made obsolete because it was not clear whether the term applied to the whole process of taste perception or just the sensory transduction stage. is_obsolete: true consider: GO:0050954 [Term] id: GO:0009593 name: detection of chemical stimulus namespace: biological_process def: "The series of events in which a chemical stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "chemoperception" EXACT [] synonym: "detection of chemical substance" EXACT [] synonym: "perception of chemical stimulus" RELATED [] synonym: "perception of chemical substance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009594 name: detection of nutrient namespace: biological_process def: "The series of events in which a nutrient stimulus is received by a cell and converted into a molecular signal." [GOC:jl] synonym: "detection of nutrients" EXACT [] synonym: "nutrient sensing" RELATED [] synonym: "perception of nutrients" RELATED [] is_a: GO:0007584 ! response to nutrient is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009595 name: detection of biotic stimulus namespace: biological_process alt_id: GO:0009596 def: "The series of events in which a biotic stimulus, one caused or produced by a living organism, is received and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of biotic stimulus" RELATED [] is_a: GO:0009607 ! response to biotic stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009597 name: detection of virus namespace: biological_process def: "The series of events in which a stimulus from a virus is received and converted into a molecular signal." [GOC:hb] subset: gosubset_prok synonym: "perception of virus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009615 ! response to virus [Term] id: GO:0009600 name: detection of nematode namespace: biological_process def: "The series of events in which a stimulus from a nematode is received and converted into a molecular signal." [GOC:hb] synonym: "perception of nematode" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009624 ! response to nematode [Term] id: GO:0009601 name: detection of insect namespace: biological_process def: "The series of events in which a stimulus from an insect is received and converted into a molecular signal." [GOC:hb] synonym: "perception of insect" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009625 ! response to insect [Term] id: GO:0009602 name: detection of symbiont namespace: biological_process def: "The series of events in which a stimulus from a symbiont (an organism living in close physical association with an organism of a different species) is received and converted into a molecular signal. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "perception of symbiont" RELATED [] is_a: GO:0009581 ! detection of external stimulus is_a: GO:0009595 ! detection of biotic stimulus is_a: GO:0009608 ! response to symbiont [Term] id: GO:0009603 name: detection of symbiotic fungus namespace: biological_process def: "The series of events in which a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of symbiotic fungi" EXACT [] synonym: "perception of symbiotic fungi" RELATED [] synonym: "perception of symbiotic fungus" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009610 ! response to symbiotic fungus is_a: GO:0016046 ! detection of fungus [Term] id: GO:0009604 name: detection of symbiotic bacterium namespace: biological_process def: "The series of events in which a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism, is received and converted into a molecular signal." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "detection of symbiotic bacteria" EXACT [] synonym: "perception of symbiotic bacteria" RELATED [] synonym: "perception of symbiotic bacterium" RELATED [] is_a: GO:0009602 ! detection of symbiont is_a: GO:0009609 ! response to symbiotic bacterium is_a: GO:0016045 ! detection of bacterium [Term] id: GO:0009605 name: response to external stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an external stimulus." [GOC:hb] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "response to environmental stimulus" EXACT [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009606 name: tropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to an external source of stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/] subset: goslim_plant xref: Wikipedia:Tropism is_a: GO:0009605 ! response to external stimulus is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0009607 name: response to biotic stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a biotic stimulus, a stimulus caused or produced by a living organism." [GOC:hb] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "response to biotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009608 name: response to symbiont namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiont, an organism living with an organism of a different species in close physical association. The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response of host to symbiont" RELATED [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009609 name: response to symbiotic bacterium namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic bacterium, a bacterium living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to symbiotic bacteria" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009617 ! response to bacterium [Term] id: GO:0009610 name: response to symbiotic fungus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a symbiotic fungus, a fungus living in close physical association with another organism." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to symbiotic fungi" EXACT [] is_a: GO:0009608 ! response to symbiont is_a: GO:0009620 ! response to fungus [Term] id: GO:0009611 name: response to wounding namespace: biological_process alt_id: GO:0002245 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to the organism." [GOC:go_curators] synonym: "physiological response to wounding" EXACT [] is_a: GO:0006950 ! response to stress [Term] id: GO:0009612 name: response to mechanical stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mechanical stimulus." [GOC:hb] subset: gosubset_prok synonym: "chemi-mechanical coupling" RELATED [] synonym: "mechanical stimulus response" EXACT [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009614 name: disease resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0051707 [Term] id: GO:0009615 name: response to virus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus." [GOC:hb] subset: gosubset_prok synonym: "response to viruses" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009616 name: virus induced gene silencing namespace: biological_process def: "Specific posttranscriptional gene inactivation ('silencing') both of viral gene(s), and host gene(s) homologous to the viral genes. This silencing is triggered by viral infection, and occurs through a specific decrease in the level of mRNA of both host and viral genes." [GOC:jl] synonym: "VIGS" EXACT [] synonym: "virus-induced gene silencing" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051607 ! defense response to virus is_a: GO:0052018 ! modulation by symbiont of RNA levels in host [Term] id: GO:0009617 name: response to bacterium namespace: biological_process alt_id: GO:0009618 alt_id: GO:0009680 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a bacterium." [GOC:hb] subset: gosubset_prok synonym: "response to bacteria" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009619 name: resistance to pathogenic bacteria namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009617 [Term] id: GO:0009620 name: response to fungus namespace: biological_process alt_id: GO:0009621 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a fungus." [GOC:hb] synonym: "response to fungi" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009622 name: resistance to pathogenic fungi namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'resistance' implies a phenotype rather than a biological process. is_obsolete: true replaced_by: GO:0009620 [Term] id: GO:0009623 name: response to parasitic fungus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a parasitic fungus, a fungus which spends all or part of its life in or on another organism from which it obtains nourishment and/or protection." [GOC:hb, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] synonym: "response to parasitic fungi" EXACT [] is_a: GO:0009610 ! response to symbiotic fungus [Term] id: GO:0009624 name: response to nematode namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a nematode." [GOC:hb] synonym: "response to nematodes" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009625 name: response to insect namespace: biological_process alt_id: GO:0043019 def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from an insect." [GOC:hb] synonym: "response to insects" EXACT [] is_a: GO:0051707 ! response to other organism [Term] id: GO:0009626 name: plant-type hypersensitive response namespace: biological_process def: "The rapid, localized death of plant cells in response to invasion by a pathogen." [ISBN:0582227089] comment: Note that term is to be used to annotate gene products in the plant. To annotate symbiont gene products that induce the hypersensitive response, consider the biological process term 'modulation by symbiont of host defense-related programmed cell death ; GO:0034053'. synonym: "HR" EXACT [] synonym: "HR-PCD" EXACT [] synonym: "plant hypersensitive response" EXACT [] is_a: GO:0033554 ! cellular response to stress is_a: GO:0034050 ! host programmed cell death induced by symbiont is_a: GO:0045087 ! innate immune response [Term] id: GO:0009627 name: systemic acquired resistance namespace: biological_process def: "The salicylic acid mediated response to a pathogen which confers broad spectrum resistance." [GOC:lr, ISBN:052143641] synonym: "salicylic acid-dependent systemic resistance" EXACT [] xref: Wikipedia:Systemic_acquired_resistance is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009628 name: response to abiotic stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abiotic (non-living) stimulus." [GOC:hb] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "response to abiotic stress" NARROW [] is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009629 name: response to gravity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gravitational stimulus." [GOC:hb] synonym: "response to gravitational stimulus" EXACT [] is_a: GO:0009628 ! response to abiotic stimulus [Term] id: GO:0009630 name: gravitropism namespace: biological_process def: "The orientation of plant parts under the stimulation of gravity." [ISBN:0198547684] synonym: "geotropism" EXACT [] xref: Wikipedia:Gravitropism is_a: GO:0009606 ! tropism is_a: GO:0009629 ! response to gravity [Term] id: GO:0009631 name: cold acclimation namespace: biological_process def: "Any process that increases freezing tolerance of an organism in response to low, nonfreezing temperatures." [GOC:syr] subset: gosubset_prok is_a: GO:0009409 ! response to cold [Term] id: GO:0009632 name: freezing tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0009409 [Term] id: GO:0009633 name: drought tolerance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'tolerance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0009414 consider: GO:0009819 [Term] id: GO:0009634 name: heavy metal sensitivity/resistance namespace: biological_process def: "OBSOLETE (was not defined before being made obsolete)." [GOC:go_curators] comment: This term was made obsolete because 'sensitivity/resistance' implies a phenotype rather than a biological process. is_obsolete: true consider: GO:0010038 [Term] id: GO:0009635 name: response to herbicide namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a herbicide stimulus. Herbicides are chemicals used to kill or control the growth of plants." [http://cancerweb.ncl.ac.uk/] subset: gosubset_prok synonym: "herbicide susceptibility/resistance" RELATED [] is_a: GO:0006950 ! response to stress is_a: GO:0009636 ! response to toxin [Term] id: GO:0009636 name: response to toxin namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxin stimulus." [GOC:lr] subset: gosubset_prok synonym: "detoxification response" NARROW [] synonym: "toxin resistance" RELATED [] synonym: "toxin susceptibility/resistance" RELATED [] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0009637 name: response to blue light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a blue light stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:ai, GOC:mtg_far_red] synonym: "response to blue light stimulus" EXACT [] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009638 name: phototropism namespace: biological_process def: "The movement of an organism, or part of an organism, in response to a light stimulus, usually toward or away from it." [GOC:jl, GOC:mtg_far_red, http://cancerweb.ncl.ac.uk/] xref: Wikipedia:Phototropism is_a: GO:0009606 ! tropism is_a: GO:0009637 ! response to blue light [Term] id: GO:0009639 name: response to red or far red light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red or far red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:ai, GOC:mtg_far_red] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009640 name: photomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation by the duration and nature of light, independent of photosynthesis." [GOC:lr] synonym: "plant development in response to light" EXACT systematic_synonym [] xref: Wikipedia:Photomorphogenesis is_a: GO:0009639 ! response to red or far red light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009641 name: shade avoidance namespace: biological_process def: "Shade avoidance is a set of responses that plants display when they are subjected to the shade of another plant. It often includes elongation, altered flowering time, increased apical dominance and altered partitioning of resources. Plants are able to distinguish between the shade of an inanimate object (e.g. a rock) and the shade of another plant due to the altered balance between red and far-red light in the shade of a plant; this balance between red and far-red light is perceived by phytochrome." [Wikipedia:Shade_avoidance] xref: Wikipedia:Shade_avoidance is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0009642 name: response to light intensity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a light intensity stimulus." [GOC:go_curators] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009643 name: photosynthetic acclimation namespace: biological_process is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009644 name: response to high light intensity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a high light intensity stimulus." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009645 name: response to low light intensity stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low light intensity stimulus. Low light intensity is defined as a level of electromagnetic radiation at or below 0.1 micromols/m2." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009646 name: response to absence of light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an absence of light stimuli." [GOC:go_curators] is_a: GO:0009642 ! response to light intensity [Term] id: GO:0009647 name: skotomorphogenesis namespace: biological_process def: "The control of plant growth, development, and differentiation in response to growth in darkness." [http://www.plantphys.net/article.php?ch=t&id=63, PMID:15012288] synonym: "etiolation" RELATED [] is_a: GO:0009646 ! response to absence of light is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0009648 name: photoperiodism namespace: biological_process def: "A change in state or activity of the organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of detection of, or exposure to, a period of light or dark of a given length, measured relative to a particular duration known as the 'critical day length'. The critical day length varies between species." [GOC:jid, GOC:pj, ISBN:0582015952, ISBN:0697037754, ISBN:0709408862] synonym: "response to day length" EXACT [] synonym: "response to night length" EXACT [] synonym: "response to photoperiod" EXACT [] xref: Wikipedia:Photoperiodism is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0009649 name: entrainment of circadian clock namespace: biological_process def: "The synchronization of a circadian rhythm to environmental time cues such as light." [GOC:jid] synonym: "regulation of circadian rhythm phase" RELATED [] is_a: GO:0009605 ! response to external stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0009650 name: UV protection namespace: biological_process def: "Any process by which an organism or cell protects itself from ultraviolet radiation (UV), which may also result in resistance to repeated exposure to UV." [GOC:jl, GOC:ml] subset: gosubset_prok synonym: "ultraviolet protection" EXACT [] synonym: "ultraviolet resistance" RELATED [] synonym: "ultraviolet tolerance" RELATED [] synonym: "UV resistance" RELATED [] synonym: "UV tolerance" RELATED [] is_a: GO:0009411 ! response to UV [Term] id: GO:0009651 name: response to salt stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of salt (particularly but not exclusively sodium and chloride ions) in the environment." [GOC:jl] subset: gosubset_prok synonym: "response to ionic osmotic stress" EXACT [] synonym: "salinity response" EXACT [] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0009652 name: thigmotropism namespace: biological_process def: "The movement of an organism, or part of an organism, such as leaves or tendrils, in response to a touch stimulus, usually toward or away from it." [GOC:jl, http://cancerweb.ncl.ac.uk/] xref: Wikipedia:Thigmotropism is_a: GO:0009606 ! tropism is_a: GO:0009612 ! response to mechanical stimulus [Term] id: GO:0009653 name: anatomical structure morphogenesis namespace: biological_process def: "The process by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators, ISBN:0521436125] subset: goslim_generic subset: goslim_plant subset: gosubset_prok synonym: "anatomical structure organization" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "morphogenesis" EXACT [] xref: Wikipedia:Morphogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0048856 ! anatomical structure development [Term] id: GO:0009654 name: oxygen evolving complex namespace: cellular_component def: "A complex, composed of a cluster of manganese, calcium and chloride ions bound to extrinsic proteins, that catalyzes the splitting of water to O2 and 4 H+. In cyanobacteria there are five extrinsic proteins in OEC (PsbO, PsbP-like, PsbQ-like, PsbU and PsbV), while in plants there are only three (PsbO, PsbP and PsbQ)." [InterPro:IPR002683] subset: gosubset_prok xref: Wikipedia:Oxygen_evolving_complex is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009655 name: PSII associated light-harvesting complex II, core complex namespace: cellular_component def: "The pigment-protein complex primarily associated to PSII in higher plants, green algae and cyanobacteria that directly transfers electrons to the reaction center." [GOC:lr] subset: gosubset_prok synonym: "PSII associated light-harvesting complex II, core complex, LHCIIa subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIIc subcomplex" NARROW [] synonym: "PSII associated light-harvesting complex II, core complex, LHCIId subcomplex" NARROW [] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009656 name: PSII associated light-harvesting complex II, peripheral complex namespace: cellular_component def: "Pigment-protein complex primarily associated to PSII in plants, green algae and cyanobacteria. Involved in state transitions that cause migration to PSI under certain environmental conditions such as high light." [GOC:lr] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009517 ! PSII associated light-harvesting complex II [Term] id: GO:0009657 name: plastid organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plastid." [GOC:mah] subset: goslim_pir synonym: "plastid organisation" EXACT [GOC:curators] synonym: "plastid organization and biogenesis" RELATED [GOC:mah] is_a: GO:0006996 ! organelle organization [Term] id: GO:0009658 name: chloroplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chloroplast." [GOC:jid] synonym: "chloroplast organisation" EXACT [GOC:curators] synonym: "chloroplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009659 name: leucoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a leucoplast. A leucoplast is a colorless plastid involved in the synthesis of monoterpenes." [GOC:jid] synonym: "leucoplast organisation" EXACT [GOC:curators] synonym: "leucoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009660 name: amyloplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an amyloplast. An amyloplast is a plastid whose main function is to synthesize and store starch." [GOC:jid] synonym: "amyloplast organisation" EXACT [GOC:curators] synonym: "amyloplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009661 name: chromoplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the chromoplast. A chromoplast is a plastid containing pigments other than chlorophyll, usually yellow and orange carotenoid pigments." [GOC:jid] synonym: "chromoplast organisation" EXACT [GOC:curators] synonym: "chromoplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009662 name: etioplast organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an etioplast. An etioplast is a plastid arrested in the development of chloroplasts from proplastids due to absence of light or low light conditions." [GOC:jid] synonym: "etioplast organisation" EXACT [GOC:curators] synonym: "etioplast organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0009663 name: plasmodesma organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a plasmodesma, a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [GOC:mah] synonym: "plasmodesma organisation" EXACT [GOC:curators] synonym: "plasmodesma organization and biogenesis" RELATED [GOC:curators] synonym: "plasmodesmata organization and biogenesis" RELATED [GOC:mah] is_a: GO:0045216 ! cell-cell junction organization [Term] id: GO:0009664 name: plant-type cell wall organization namespace: biological_process def: "A process that results in the assembly and arrangement of constituent parts of the cellulose and pectin-containing cell wall, or in the disassembly of the cellulose and pectin-containing cell wall. This process is carried out at the cellular level. An example of this process is found in Arabidopsis thaliana." [GOC:jid, GOC:mtg_sensu] synonym: "cell wall organization and biogenesis" NARROW [] synonym: "cellulose and pectin-containing cell wall organization and biogenesis" RELATED [GOC:mah] synonym: "plant-type cell wall organisation" EXACT [GOC:curators] synonym: "plant-type cell wall organization and biogenesis" RELATED [GOC:mah] is_a: GO:0071555 ! cell wall organization is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009665 name: plastid inheritance namespace: biological_process def: "The partitioning of plastids between daughter cells at cell division." [GOC:mah] is_a: GO:0009657 ! plastid organization is_a: GO:0048308 ! organelle inheritance [Term] id: GO:0009666 name: plastid outer membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the outer membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid outer membrane organisation" EXACT [GOC:curators] synonym: "plastid outer membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009667 name: plastid inner membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the inner membrane of a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid inner membrane organisation" EXACT [GOC:curators] synonym: "plastid inner membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0009668 name: plastid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of either of the lipid bilayers surrounding a plastid." [GOC:ai, GOC:dph, GOC:jl, GOC:mah] synonym: "plastid membrane organisation" EXACT [GOC:curators] synonym: "plastid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0016044 ! cellular membrane organization relationship: part_of GO:0009657 ! plastid organization [Term] id: GO:0009669 name: sucrose:monovalent cation symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sucrose(out) + monovalent cation(out) = sucrose(in) + monovalent cation(in)." [GOC:jy, TC:2.A.2.-.-, TC:2.A.2.4.1] synonym: "sucrose permease activity" RELATED [] is_a: GO:0008515 ! sucrose transmembrane transporter activity is_a: GO:0015486 ! glycoside-pentoside-hexuronide:cation symporter activity [Term] id: GO:0009670 name: triose-phosphate:phosphate antiporter activity namespace: molecular_function alt_id: GO:0015122 def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: triose-phosphate(out) + phosphate(in) = triose-phosphate(in) + phosphate(out)." [GOC:bf, GOC:jl, GOC:mtg_transport, ISBN:0815340729, TC:2.A.7.-.-] synonym: "dihydroxyacetone phosphate:phosphate antiporter activity" EXACT [] synonym: "TPT" RELATED [] synonym: "triose phosphate antiporter" EXACT [] synonym: "triose phosphate translocator" EXACT [] synonym: "triose phosphate transporter activity" EXACT [] synonym: "triose-phosphate transmembrane transporter activity" EXACT [] is_a: GO:0015145 ! monosaccharide transmembrane transporter activity is_a: GO:0015301 ! anion:anion antiporter activity relationship: part_of GO:0035436 ! triose phosphate transmembrane transport [Term] id: GO:0009671 name: nitrate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: nitrate(out) + H+(out) = nitrate(in) + H+(in)." [GOC:mah, PMID:10066586, PMID:1990981] synonym: "nitrate(chlorate):hydrogen symporter activity" EXACT [] synonym: "nitrate(chlorate):proton symporter activity" EXACT [] is_a: GO:0015078 ! hydrogen ion transmembrane transporter activity is_a: GO:0015112 ! nitrate transmembrane transporter activity is_a: GO:0015296 ! anion:cation symporter activity [Term] id: GO:0009672 name: auxin:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: auxin(out) + H+(out) = auxin(in) + H+(in)." [PMID:8688077] synonym: "auxin:proton symporter activity" EXACT [] is_a: GO:0015294 ! solute:cation symporter activity relationship: part_of GO:0015992 ! proton transport relationship: part_of GO:0060918 ! auxin transport [Term] id: GO:0009673 name: low affinity phosphate transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of phosphate from one side of the membrane to the other. In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [TC:2.A.20.-.-] is_a: GO:0015114 ! phosphate transmembrane transporter activity [Term] id: GO:0009674 name: potassium:sodium symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: K+(out) + Na+(out) = K+(in) + Na+(in)." [TC:2.A.38.3.1] synonym: "high affinity potassium transporter" RELATED [] is_a: GO:0022820 ! potassium ion symporter activity [Term] id: GO:0009675 name: high affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In high affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations." [GOC:mah] synonym: "high affinity sulfate:proton symporter activity" EXACT [] synonym: "high affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:hydrogen symporter activity [Term] id: GO:0009676 name: low affinity sulfate:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: sulfate(out) + H+(out) = sulfate(in) + H+(in). In low affinity transport the transporter is able to bind the solute only if it is present at very high concentrations." [GOC:mah, PMID:7568135] synonym: "low affinity sulfate:proton symporter activity" EXACT [] synonym: "low affinity sulphate:hydrogen symporter activity" EXACT [] is_a: GO:0008512 ! sulfate:hydrogen symporter activity [Term] id: GO:0009677 name: double fertilization forming two zygotes namespace: biological_process def: "Rudimentary double fertilization where one of the two sperm nuclei from the pollen tube fuses with the egg nucleus to form a 2n zygote, and the other fuses with the ventral canal cell nucleus to form a second zygote, which soon degenerates. An example of this process is found in the Gnetophytes, such as Welwitschia mirabilis." [GOC:mtg_sensu, GOC:tb] is_a: GO:0009566 ! fertilization [Term] id: GO:0009678 name: hydrogen-translocating pyrophosphatase activity namespace: molecular_function def: "Catalysis of the hydrolysis of pyrophosphate, which generates a proton motive force." [GOC:mtg_transport, ISBN:0815340729, TC:3.A.10.-.-] subset: gosubset_prok synonym: "proton-translocating pyrophosphatase activity" EXACT [] is_a: GO:0015405 ! P-P-bond-hydrolysis-driven transmembrane transporter activity is_a: GO:0016462 ! pyrophosphatase activity [Term] id: GO:0009679 name: hexose:hydrogen symporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: hexose(out) + H+(out) = hexose(in) + H+(in)." [TC:2.A.1.-.-] subset: gosubset_prok synonym: "hexose:proton symporter activity" EXACT [] is_a: GO:0005351 ! sugar:hydrogen symporter activity is_a: GO:0015149 ! hexose transmembrane transporter activity [Term] id: GO:0009682 name: induced systemic resistance namespace: biological_process def: "A response to non-pathogenic bacteria that confers broad spectrum systemic resistance to disease that does not depend upon salicylic acid signaling." [PMID:10234273] is_a: GO:0042742 ! defense response to bacterium is_a: GO:0045087 ! innate immune response [Term] id: GO:0009683 name: indoleacetic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving indole-3-acetic acid, a compound which functions as a growth regulator in plants." [GOC:mah] subset: gosubset_prok synonym: "IAA metabolic process" EXACT [] synonym: "indole acetic acid metabolic process" EXACT [] synonym: "indole acetic acid metabolism" EXACT [] synonym: "indoleacetic acid metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0042434 ! indole derivative metabolic process [Term] id: GO:0009684 name: indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid, a compound which functions as a growth regulator in plants." [ISBN:0387969845] subset: gosubset_prok synonym: "IAA biosynthetic process" EXACT [] synonym: "indole acetic acid biosynthesis" EXACT [] synonym: "indole acetic acid biosynthetic process" EXACT [] synonym: "indole-3-acetate biosynthesis" EXACT [] synonym: "indole-3-acetate biosynthetic process" EXACT [] synonym: "indole-acetic acid biosynthesis" EXACT [] synonym: "indole-acetic acid biosynthetic process" RELATED [] synonym: "indoleacetic acid anabolism" EXACT [] synonym: "indoleacetic acid biosynthesis" EXACT [] synonym: "indoleacetic acid formation" EXACT [] synonym: "indoleacetic acid synthesis" EXACT [] is_a: GO:0009683 ! indoleacetic acid metabolic process is_a: GO:0009851 ! auxin biosynthetic process is_a: GO:0042435 ! indole derivative biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009685 name: gibberellin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "gibberellic acid metabolic process" NARROW [] synonym: "gibberellic acid metabolism" NARROW [] synonym: "gibberellin metabolism" EXACT [] is_a: GO:0016101 ! diterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009686 name: gibberellin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of gibberellin. Gibberellins are a class of highly modified terpenes that function as plant growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "gibberellic acid anabolism" NARROW [] synonym: "gibberellic acid biosynthesis" NARROW [] synonym: "gibberellic acid biosynthetic process" NARROW [] synonym: "gibberellic acid formation" NARROW [] synonym: "gibberellic acid synthesis" NARROW [] synonym: "gibberellin biosynthesis" EXACT [] xref: MetaCyc:PWY-5035 xref: MetaCyc:PWY-5036 xref: MetaCyc:PWY-5052 xref: MetaCyc:PWY-5070 is_a: GO:0009685 ! gibberellin metabolic process is_a: GO:0016102 ! diterpenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009687 name: abscisic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "abscisic acid metabolism" EXACT [] is_a: GO:0006714 ! sesquiterpenoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process is_a: GO:0043288 ! apocarotenoid metabolic process [Term] id: GO:0009688 name: abscisic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of abscisic acid, 5-(1-hydroxy-2,6,6,trimethyl-4-oxocyclohex-2-en-1-y1)-3-methylpenta-2,4-dienoic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "abscisic acid anabolism" EXACT [] synonym: "abscisic acid biosynthesis" EXACT [] synonym: "abscisic acid formation" EXACT [] synonym: "abscisic acid synthesis" EXACT [] xref: MetaCyc:PWY-695 is_a: GO:0009687 ! abscisic acid metabolic process is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0043289 ! apocarotenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009689 name: induction of phytoalexin biosynthetic process namespace: biological_process def: "The activation of the chemical reactions and pathways resulting in the formation of phytoalexins, low-molecular mass, lipophilic antimicrobial compounds that accumulate rapidly at sites of incompatible pathogen infection." [ISBN:0943088399] synonym: "induction of phytoalexin anabolism" EXACT [] synonym: "induction of phytoalexin biosynthesis" EXACT [] synonym: "induction of phytoalexin formation" EXACT [] synonym: "induction of phytoalexin synthesis" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0052322 ! positive regulation of phytoalexin biosynthetic process [Term] id: GO:0009690 name: cytokinin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "cytokinin metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0009308 ! amine metabolic process is_a: GO:0034754 ! cellular hormone metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009691 name: cytokinin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators." [ISBN:0387969845] subset: gosubset_prok synonym: "cytokinin anabolism" EXACT [] synonym: "cytokinin biosynthesis" EXACT [] synonym: "cytokinin formation" EXACT [] synonym: "cytokinin synthesis" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009692 name: ethylene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] subset: gosubset_prok synonym: "ethene metabolic process" EXACT [] synonym: "ethene metabolism" EXACT [] synonym: "ethylene metabolism" EXACT [] xref: Reactome:549281 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:576052 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:599306 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:622726 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:640393 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:651087 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:697356 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:711033 "Ethylene is oxidized to Ethylene oxide by CYP1A1" xref: Reactome:76472 "Ethylene is oxidized to Ethylene oxide by CYP1A1" is_a: GO:0006575 ! cellular amino acid derivative metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0009693 name: ethylene biosynthetic process namespace: biological_process alt_id: GO:0042456 def: "The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator." [ISBN:0387969845] subset: gosubset_prok synonym: "ethene biosynthesis" EXACT [] synonym: "ethene biosynthesis from L-methionine" EXACT [] synonym: "ethene biosynthetic process" EXACT [] synonym: "ethene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene anabolism" EXACT [] synonym: "ethylene biosynthesis" EXACT [] synonym: "ethylene biosynthesis from L-methionine" EXACT [] synonym: "ethylene biosynthetic process from L-methionine" EXACT [] synonym: "ethylene formation" EXACT [] synonym: "ethylene synthesis" EXACT [] xref: MetaCyc:ETHYL-PWY is_a: GO:0006555 ! methionine metabolic process is_a: GO:0009692 ! ethylene metabolic process is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009694 name: jasmonic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving jasmonic acid, a fatty acid derivative with the formula (1R-(1 alpha, 2 beta(Z)))-3-oxo-2-(2-pentenyl)cyclopentaneacetic acid." [ISBN:0387969845] subset: gosubset_prok synonym: "jasmonic acid metabolism" EXACT [] is_a: GO:0031407 ! oxylipin metabolic process [Term] id: GO:0009695 name: jasmonic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of jasmonic acid, a fatty acid derivative." [ISBN:0387969845] synonym: "jasmonic acid anabolism" EXACT [] synonym: "jasmonic acid biosynthesis" EXACT [] synonym: "jasmonic acid formation" EXACT [] synonym: "jasmonic acid synthesis" EXACT [] xref: MetaCyc:PWY-735 is_a: GO:0009694 ! jasmonic acid metabolic process is_a: GO:0031408 ! oxylipin biosynthetic process [Term] id: GO:0009696 name: salicylic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] subset: gosubset_prok synonym: "salicylic acid metabolism" EXACT [] is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009697 name: salicylic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of salicylic acid (2-hydroxybenzoic acid), a derivative of benzoic acid." [ISBN:0943088399] subset: gosubset_prok synonym: "salicylate biosynthetic process" EXACT [] synonym: "salicylic acid anabolism" EXACT [] synonym: "salicylic acid biosynthesis" EXACT [] synonym: "salicylic acid formation" EXACT [] synonym: "salicylic acid synthesis" EXACT [] xref: MetaCyc:PWY-981 is_a: GO:0009696 ! salicylic acid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0009698 name: phenylpropanoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving aromatic derivatives of trans-cinnamic acid." [GOC:jl] subset: gosubset_prok synonym: "phenylpropanoid metabolism" EXACT [] xref: MetaCyc:PWY1F-467 is_a: GO:0006575 ! cellular amino acid derivative metabolic process is_a: GO:0006725 ! cellular aromatic compound metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0009699 name: phenylpropanoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of aromatic derivatives of trans-cinnamic acid." [GOC:jl] subset: gosubset_prok synonym: "phenylpropanoid anabolism" EXACT [] synonym: "phenylpropanoid biosynthesis" EXACT [] synonym: "phenylpropanoid formation" EXACT [] synonym: "phenylpropanoid synthesis" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0042398 ! cellular amino acid derivative biosynthetic process [Term] id: GO:0009700 name: indole phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole phytoalexins, any indole compound produced by plants as part of their defense response." [GOC:sm, ISBN:0198547684] synonym: "indole phytoalexin anabolism" EXACT [] synonym: "indole phytoalexin biosynthesis" EXACT [] synonym: "indole phytoalexin formation" EXACT [] synonym: "indole phytoalexin synthesis" EXACT [] is_a: GO:0042435 ! indole derivative biosynthetic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process is_a: GO:0046217 ! indole phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009701 name: isoflavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoid phytoalexins, a group of water-soluble phenolic derivatives isomeric with flavonoids that possess antibiotic activity and are produced by plant tissues in response to infection." [GOC:ai] synonym: "isoflavonoid phytoalexin anabolism" EXACT [] synonym: "isoflavonoid phytoalexin biosynthesis" EXACT [] synonym: "isoflavonoid phytoalexin formation" EXACT [] synonym: "isoflavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009716 ! flavonoid phytoalexin biosynthetic process is_a: GO:0009717 ! isoflavonoid biosynthetic process is_a: GO:0046289 ! isoflavonoid phytoalexin metabolic process [Term] id: GO:0009702 name: L-arabinokinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + L-arabinose = ADP + beta-L-arabinose 1-phosphate." [EC:2.7.1.46] synonym: "ATP:L-arabinose 1-phosphotransferase activity" EXACT [] synonym: "L-arabinokinase (phosphorylating)" EXACT [EC:2.7.1.46] xref: EC:2.7.1.46 xref: MetaCyc:L-ARABINOKINASE-RXN is_a: GO:0016773 ! phosphotransferase activity, alcohol group as acceptor is_a: GO:0019200 ! carbohydrate kinase activity [Term] id: GO:0009703 name: nitrate reductase (NADH) activity namespace: molecular_function def: "Catalysis of the reaction: NO2- (nitrite) + NAD+ + H2O = NO3- (nitrate) + NADH + H+." [EC:1.7.1.1] comment: Note that this function was formerly EC:1.6.6.1. synonym: "assimilatory NADH: nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory NADH:nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "assimilatory nitrate reductase activity" BROAD [EC:1.7.1.1] synonym: "NADH-dependent nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH-nitrate reductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate oxidoreductase activity" EXACT [EC:1.7.1.1] synonym: "NADH:nitrate reductase activity" EXACT [] synonym: "nitrate reductase (NADH(2)) activity" EXACT [EC:1.7.1.1] synonym: "nitrate reductase (NADH2)" EXACT [EC:1.7.1.1] synonym: "nitrite:NAD+ oxidoreductase activity" EXACT [EC:1.7.1.1] xref: EC:1.7.1.1 xref: MetaCyc:NITRATE-REDUCTASE-NADH-RXN is_a: GO:0008940 ! nitrate reductase activity is_a: GO:0046857 ! oxidoreductase activity, acting on other nitrogenous compounds as donors, with NAD or NADP as acceptor [Term] id: GO:0009704 name: de-etiolation namespace: biological_process def: "The greening response of plants grown in the dark (etiolated) as a result of chloroplast biogenesis and the accumulation of chlorophyll." [GOC:lr] is_a: GO:0009416 ! response to light stimulus relationship: part_of GO:0009640 ! photomorphogenesis [Term] id: GO:0009705 name: plant-type vacuole membrane namespace: cellular_component def: "The lipid bilayer surrounding a vacuole that retains the same shape regardless of cell cycle phase. The membrane separates its contents from the cytoplasm of the cell. An example of this component is found in Arabidopsis thaliana." [GOC:mtg_sensu, ISBN:0471245208] synonym: "membrane of vacuole with cell cycle-independent morphology" EXACT [] synonym: "tonoplast" EXACT [] synonym: "vacuolar membrane" BROAD [] is_a: GO:0005774 ! vacuolar membrane relationship: part_of GO:0000325 ! plant-type vacuole [Term] id: GO:0009706 name: chloroplast inner membrane namespace: cellular_component def: "The inner, i.e. lumen-facing, lipid bilayer of the chloroplast envelope; also faces the chloroplast stroma." [GOC:tb] synonym: "chloroplast inner envelope" EXACT [] is_a: GO:0009528 ! plastid inner membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009707 name: chloroplast outer membrane namespace: cellular_component def: "The outer, i.e. cytoplasm-facing, lipid bilayer of the chloroplast envelope." [GOC:tb] synonym: "chloroplast outer envelope" EXACT [] is_a: GO:0009527 ! plastid outer membrane is_a: GO:0031969 ! chloroplast membrane [Term] id: GO:0009708 name: benzyl isoquinoline alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of benzyl isoquinoline alkaloids, compounds with bicyclic N-containing aromatic rings." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "benzyl isoquinoline alkaloid anabolism" EXACT [] synonym: "benzyl isoquinoline alkaloid biosynthesis" EXACT [] synonym: "benzyl isoquinoline alkaloid formation" EXACT [] synonym: "benzyl isoquinoline alkaloid synthesis" EXACT [] is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0033075 ! isoquinoline alkaloid biosynthetic process is_a: GO:0046445 ! benzyl isoquinoline alkaloid metabolic process [Term] id: GO:0009709 name: terpenoid indole alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of terpenoid indole alkaloids, compounds formed from the condensation of tryptamine (derived from tryptophan) and secologanin (derived from geranyl pyrophosphate)." [GOC:ai, http://rycomusa.com/aspp2000/public/P29/0525.html] subset: gosubset_prok synonym: "terpenoid indole alkaloid anabolism" EXACT [] synonym: "terpenoid indole alkaloid biosynthesis" EXACT [] synonym: "terpenoid indole alkaloid formation" EXACT [] synonym: "terpenoid indole alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0042434 ! indole derivative metabolic process is_a: GO:0046447 ! terpenoid indole alkaloid metabolic process [Term] id: GO:0009710 name: tropane alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of tropane alkaloids, compounds containing the 8-methyl-8-azabicyclo(3.2.1)octane ring system." [GOC:ai, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "tropane alkaloid anabolism" EXACT [] synonym: "tropane alkaloid biosynthesis" EXACT [] synonym: "tropane alkaloid formation" EXACT [] synonym: "tropane alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0018130 ! heterocycle biosynthetic process is_a: GO:0046448 ! tropane alkaloid metabolic process [Term] id: GO:0009711 name: purine alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of purine alkaloids, compounds derived from purine and composed of an N-containing double ring structure." [GOC:ai] subset: gosubset_prok synonym: "purine alkaloid anabolism" EXACT [] synonym: "purine alkaloid biosynthesis" EXACT [] synonym: "purine alkaloid formation" EXACT [] synonym: "purine alkaloid synthesis" EXACT [] is_a: GO:0009821 ! alkaloid biosynthetic process is_a: GO:0046446 ! purine alkaloid metabolic process [Term] id: GO:0009712 name: catechol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a compound containing a pyrocatechol (1,2-benzenediol) nucleus or substituent." [GOC:sm, ISBN:0198547684] subset: gosubset_prok synonym: "catechol metabolism" EXACT [] is_a: GO:0018958 ! phenol metabolic process is_a: GO:0034311 ! diol metabolic process [Term] id: GO:0009713 name: catechol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of catechol, a compound containing a pyrocatechol nucleus or substituent." [GOC:go_curators] subset: gosubset_prok synonym: "catechol anabolism" EXACT [] synonym: "catechol biosynthesis" EXACT [] synonym: "catechol formation" EXACT [] synonym: "catechol synthesis" EXACT [] is_a: GO:0009712 ! catechol metabolic process is_a: GO:0034312 ! diol biosynthetic process [Term] id: GO:0009714 name: chalcone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving chalcones, phenyl steryl ketone or its hydroxylated derivatives." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "chalcone metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0042180 ! cellular ketone metabolic process [Term] id: GO:0009715 name: chalcone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of chalcone, phenyl steryl ketone or its hydroxylated derivatives." [GOC:go_curators] subset: gosubset_prok synonym: "chalcone anabolism" EXACT [] synonym: "chalcone biosynthesis" EXACT [] synonym: "chalcone formation" EXACT [] synonym: "chalcone synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009714 ! chalcone metabolic process is_a: GO:0042181 ! ketone biosynthetic process [Term] id: GO:0009716 name: flavonoid phytoalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoid phytoalexins, a group of water-soluble phenolic derivatives containing a flavan skeleton, which possess antibiotic activity and are produced by plant tissues in response to infection." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok synonym: "flavonoid phytoalexin anabolism" EXACT [] synonym: "flavonoid phytoalexin biosynthesis" EXACT [] synonym: "flavonoid phytoalexin formation" EXACT [] synonym: "flavonoid phytoalexin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046285 ! flavonoid phytoalexin metabolic process is_a: GO:0052315 ! phytoalexin biosynthetic process [Term] id: GO:0009717 name: isoflavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of isoflavonoids, a group of water-soluble phenolic derivatives, isomeric with flavonoids." [GOC:ai] subset: gosubset_prok synonym: "isoflavonoid anabolism" EXACT [] synonym: "isoflavonoid biosynthesis" EXACT [] synonym: "isoflavonoid formation" EXACT [] synonym: "isoflavonoid synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046287 ! isoflavonoid metabolic process [Term] id: GO:0009718 name: anthocyanin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of anthocyanins, any member of a group of intensely colored soluble glycosides of anthocyanidins." [GOC:ai] subset: gosubset_prok synonym: "anthocyanin anabolism" EXACT [] synonym: "anthocyanin biosynthesis" EXACT [] synonym: "anthocyanin formation" EXACT [] synonym: "anthocyanin synthesis" EXACT [] is_a: GO:0009813 ! flavonoid biosynthetic process is_a: GO:0046148 ! pigment biosynthetic process is_a: GO:0046283 ! anthocyanin metabolic process [Term] id: GO:0009719 name: response to endogenous stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus arising within the organism." [GOC:sm] subset: goslim_generic subset: goslim_plant subset: gosubset_prok is_a: GO:0050896 ! response to stimulus [Term] id: GO:0009720 name: detection of hormone stimulus namespace: biological_process def: "The series of events in which a hormone stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of hormone stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009725 ! response to hormone stimulus is_a: GO:0009726 ! detection of endogenous stimulus [Term] id: GO:0009721 name: detection of auxin stimulus namespace: biological_process def: "The series of events in which an auxin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of auxin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009733 ! response to auxin stimulus [Term] id: GO:0009722 name: detection of cytokinin stimulus namespace: biological_process def: "The series of events in which a cytokinin stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of cytokinin stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009735 ! response to cytokinin stimulus [Term] id: GO:0009723 name: response to ethylene stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ethylene (ethene) stimulus." [GOC:jl] synonym: "response to ethene stimulus" EXACT [] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009724 name: detection of abscisic acid stimulus namespace: biological_process def: "The series of events in which an abscisic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of abscisic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009737 ! response to abscisic acid stimulus [Term] id: GO:0009725 name: response to hormone stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus." [GOC:jl] synonym: "growth regulator" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009726 name: detection of endogenous stimulus namespace: biological_process def: "The series of events in which an endogenous stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of endogenous stimulus" RELATED [] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0051606 ! detection of stimulus [Term] id: GO:0009727 name: detection of ethylene stimulus namespace: biological_process def: "The series of events in which an ethylene (ethene) stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "detection of ethene stimulus" EXACT [] synonym: "perception of ethene stimulus" RELATED [] synonym: "perception of ethylene stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009723 ! response to ethylene stimulus [Term] id: GO:0009728 name: detection of gibberellic acid stimulus namespace: biological_process def: "The series of events in which a gibberellic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of gibberellic acid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009739 ! response to gibberellin stimulus [Term] id: GO:0009729 name: detection of brassinosteroid stimulus namespace: biological_process def: "The series of events in which a brassinosteroid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of brassinosteroid stimulus" RELATED [] is_a: GO:0009720 ! detection of hormone stimulus is_a: GO:0009741 ! response to brassinosteroid stimulus [Term] id: GO:0009730 name: detection of carbohydrate stimulus namespace: biological_process def: "The series of events in which a carbohydrate stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of carbohydrate stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0009731 name: detection of sucrose stimulus namespace: biological_process def: "The series of events in which a sucrose stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of sucrose stimulus" RELATED [] is_a: GO:0009744 ! response to sucrose stimulus is_a: GO:0034288 ! detection of disaccharide stimulus [Term] id: GO:0009732 name: detection of hexose stimulus namespace: biological_process def: "The series of events in which a stimulus from a hexose is received and converted into a molecular signal." [GOC:sm] synonym: "perception of hexose stimulus" RELATED [] is_a: GO:0009746 ! response to hexose stimulus is_a: GO:0034287 ! detection of monosaccharide stimulus [Term] id: GO:0009733 name: response to auxin stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an auxin stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009734 name: auxin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated in response to detection of auxin." [GOC:mah, GOC:sm] synonym: "auxin mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071365 ! cellular response to auxin stimulus [Term] id: GO:0009735 name: response to cytokinin stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytokinin stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009736 name: cytokinin mediated signaling pathway namespace: biological_process def: "A series of molecular signals induced by the detection of cytokinin." [GOC:sm] synonym: "cytokinin mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071368 ! cellular response to cytokinin stimulus [Term] id: GO:0009737 name: response to abscisic acid stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an abscisic acid stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009738 name: abscisic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of abscisic acid." [GOC:sm] synonym: "abscisic acid mediated signalling" EXACT [] is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071215 ! cellular response to abscisic acid stimulus [Term] id: GO:0009739 name: response to gibberellin stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gibberellin stimulus." [GOC:jl] synonym: "response to gibberellic acid stimulus" NARROW [] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009740 name: gibberellic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of gibberellic acid." [GOC:sm] synonym: "GA-signaling" EXACT [] synonym: "gibberellic acid mediated signalling" EXACT [] synonym: "gibberellic acid signaling" EXACT [] is_a: GO:0010476 ! gibberellin mediated signaling pathway is_a: GO:0071370 ! cellular response to gibberellin stimulus [Term] id: GO:0009741 name: response to brassinosteroid stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brassinosteroid stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009742 name: brassinosteroid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of brassinosteroid." [GOC:sm] synonym: "brassinosteroid mediated signalling" EXACT [] is_a: GO:0043401 ! steroid hormone mediated signaling pathway is_a: GO:0071367 ! cellular response to brassinosteroid stimulus [Term] id: GO:0009743 name: response to carbohydrate stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbohydrate stimulus." [GOC:jl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009744 name: response to sucrose stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sucrose stimulus." [GOC:jl] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0009745 name: sucrose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of sucrose." [GOC:sm] synonym: "sucrose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway is_a: GO:0071329 ! cellular response to sucrose stimulus [Term] id: GO:0009746 name: response to hexose stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hexose stimulus." [GOC:jl] is_a: GO:0034284 ! response to monosaccharide stimulus [Term] id: GO:0009747 name: hexokinase-dependent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and dependent on the detection of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-dependent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009748 name: hexokinase-independent signaling namespace: biological_process def: "A series of molecular signals mediated by hexose and independent of hexokinase." [GOC:mah, GOC:sm] synonym: "hexokinase-independent signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling [Term] id: GO:0009749 name: response to glucose stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucose stimulus." [GOC:jl] is_a: GO:0009746 ! response to hexose stimulus [Term] id: GO:0009750 name: response to fructose stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus." [GOC:jl] is_a: GO:0009746 ! response to hexose stimulus [Term] id: GO:0009751 name: response to salicylic acid stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a salicylic acid stimulus." [GOC:jl] is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009752 name: detection of salicylic acid stimulus namespace: biological_process def: "The series of events in which a salicylic acid stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "perception of salicylic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009751 ! response to salicylic acid stimulus [Term] id: GO:0009753 name: response to jasmonic acid stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus." [GOC:jl] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0009754 name: detection of jasmonic acid stimulus namespace: biological_process def: "The series of events in which a jasmonic acid stimulus is received by a cell and converted into a molecular signal. Series of events required for a jasmonic acid stimulus to be detected and converted to a signal molecule." [GOC:sm] synonym: "perception of jasmonic acid stimulus" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus is_a: GO:0009726 ! detection of endogenous stimulus is_a: GO:0009753 ! response to jasmonic acid stimulus [Term] id: GO:0009755 name: hormone-mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by the detection of a hormone." [GOC:sm] synonym: "hormone mediated signalling" EXACT [] xref: Reactome:163359 "Glucagon signaling in metabolic regulation" xref: Reactome:562672 "Glucagon signaling in metabolic regulation" xref: Reactome:588297 "Glucagon signaling in metabolic regulation" xref: Reactome:609037 "Glucagon signaling in metabolic regulation" xref: Reactome:633730 "Glucagon signaling in metabolic regulation" xref: Reactome:645344 "Glucagon signaling in metabolic regulation" xref: Reactome:655718 "Glucagon signaling in metabolic regulation" xref: Reactome:661117 "Glucagon signaling in metabolic regulation" xref: Reactome:666893 "Glucagon signaling in metabolic regulation" xref: Reactome:673015 "Glucagon signaling in metabolic regulation" xref: Reactome:678735 "Glucagon signaling in metabolic regulation" xref: Reactome:689878 "Glucagon signaling in metabolic regulation" xref: Reactome:728166 "Glucagon signaling in metabolic regulation" xref: Reactome:731020 "Glucagon signaling in metabolic regulation" is_a: GO:0023033 ! signaling pathway is_a: GO:0032870 ! cellular response to hormone stimulus [Term] id: GO:0009756 name: carbohydrate mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of carbohydrate." [GOC:sm] synonym: "carbohydrate mediated signalling" EXACT [] is_a: GO:0023033 ! signaling pathway is_a: GO:0071322 ! cellular response to carbohydrate stimulus [Term] id: GO:0009757 name: hexose mediated signaling namespace: biological_process def: "A series of molecular signals mediated by the detection of hexose." [GOC:sm] synonym: "hexose mediated signalling" EXACT [] is_a: GO:0010182 ! sugar mediated signaling pathway is_a: GO:0071331 ! cellular response to hexose stimulus [Term] id: GO:0009758 name: carbohydrate utilization namespace: biological_process def: "A series of processes that forms an integrated mechanism by which a cell or an organism detects the depletion of primary carbohydrate sources,usually glucose, and then activates genes to scavenge the last traces of the primary carbohydrate source and to transport and metabolize alternate carbohydrate sources. The utilization process begins when the cell or organism detects carbohydrate levels, includes the activation of genes whose products detect, transport or metabolize carbohydrates, and ends when the carbohydrate is incorporated into the cell or organism's metabolism." [GOC:mah, GOC:mlg] is_a: GO:0008150 ! biological_process relationship: has_part GO:0005975 ! carbohydrate metabolic process relationship: has_part GO:0008643 ! carbohydrate transport relationship: has_part GO:0009730 ! detection of carbohydrate stimulus [Term] id: GO:0009759 name: indole glucosinolate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole glucosinolates, sulfur-containing compounds that have a common structure linked to an R group derived from tryptophan." [GOC:ai] subset: gosubset_prok synonym: "indole glucosinolate anabolism" EXACT [] synonym: "indole glucosinolate biosynthesis" EXACT [] synonym: "indole glucosinolate formation" EXACT [] synonym: "indole glucosinolate synthesis" EXACT [] xref: MetaCyc:PWY-601 is_a: GO:0019761 ! glucosinolate biosynthetic process is_a: GO:0042343 ! indole glucosinolate metabolic process is_a: GO:0042435 ! indole derivative biosynthetic process [Term] id: GO:0009760 name: C4 photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) in the mesophyll cells to make a 4-carbon acid which is immediately converted to malic acid. The malic acid is then passed across to the bundle sheath cells where it is broken down again to pyruvic acid and CO2. The acid is passed back to the mesophyll cells to be used again, while the CO2 is fed into the reductive pentose-phosphate cycle (Calvin cycle) and converted into sugar and starch." [ISBN:0816017360] xref: Wikipedia:C4_carbon_fixation is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction is_a: GO:0044236 ! multicellular organismal metabolic process [Term] id: GO:0009761 name: CAM photosynthesis namespace: biological_process def: "The combination of atmospheric CO2 with a 3-carbon molecule phosphoenol pyruvate (PEP) to make malic acid. The malic acid is then passed into the vacuole where it is stored until daylight, when it is shuttled back out to be used as a substrate in the light reaction of photosynthesis." [ISBN:0582015952] xref: Wikipedia:Crassulacean_acid_metabolism is_a: GO:0015977 ! carbon fixation is_a: GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0009762 name: NADP-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NADP-malic enzyme." [PMID:11788762] xref: MetaCyc:PWY-241 is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009763 name: NAD-malic enzyme C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is NAD-malic enzyme." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009764 name: PEP carboxykinase C4 photosynthesis namespace: biological_process def: "The process of C4 photosynthesis, as it occurs in plants in which the enzyme decarboxylating C4 acids in the bundle sheath is phosphoenolpyruvate carboxykinase (PEPCK)." [PMID:11788762] is_a: GO:0009760 ! C4 photosynthesis [Term] id: GO:0009765 name: photosynthesis, light harvesting namespace: biological_process def: "Absorption and transfer of the energy absorbed from light photons between photosystem reaction centers." [GOC:sm] synonym: "energy dissipation" RELATED [] is_a: GO:0006091 ! generation of precursor metabolites and energy relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009766 name: primary charge separation namespace: biological_process def: "In the photosynthetic reaction centers, primary charge separation is initiated by the excitation of a molecule followed by the transfer of an electron to an electron acceptor molecule following energy transfer from light harvesting complexes." [ISBN:0792361431] is_a: GO:0022904 ! respiratory electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009767 name: photosynthetic electron transport chain namespace: biological_process def: "A process, occurring as part of photosynthesis, whereby light provides the energy for a series of electron carriers to operate together to transfer electrons and generate a transmembrane electrochemical gradient." [GOC:mtg_electron_transport, ISBN:0198547684] synonym: "electron carrier, chlorophyll electron transport system" EXACT [] is_a: GO:0022900 ! electron transport chain relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009768 name: photosynthesis, light harvesting in photosystem I namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem I, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009769 name: photosynthesis, light harvesting in photosystem II namespace: biological_process def: "After a photon of light is absorbed by one of the many chlorophyll molecules, in one of the light-harvesting complexes of an antenna on photosystem II, some of the absorbed energy is transferred to the pair of chlorophyll molecules in the reaction center." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0009770 name: primary charge separation in photosystem I namespace: biological_process def: "Energized reaction-center P700 chlorophylls on photosystem I donate an electron to a loosely bound Quinone acceptor molecule X, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009771 name: primary charge separation in photosystem II namespace: biological_process def: "Energized reaction-center P680 chlorophylls on photosystem II donate an electron to a loosely bound acceptor molecule, the quinone Q, on the stromal surface of the thylakoid membrane. The result is charge separation; a negative charge on the stromal side of the thylakoid membrane and a positive charge on the luminal side." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009766 ! primary charge separation [Term] id: GO:0009772 name: photosynthetic electron transport in photosystem II namespace: biological_process def: "Electrons move from the primary electron acceptor (Quinone, Q) through a chain of electron transport molecules in the thylakoid membrane until they reach the ultimate electron acceptor of Photosystem II, which is plastocyanin (PC). The electron is then passed to the P700 chlorophyll a molecules of the reaction centre of photosystem I." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009773 name: photosynthetic electron transport in photosystem I namespace: biological_process def: "Electrons move from the primary electron acceptor (Quinone, X) through a chain of electron transport molecules in the thylakoid membrane until they reach ferredoxin which passes the electron to the ultimate electron acceptor; NADP." [GOC:jid, ISBN:0716731363, ISBN:0816017360] is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009774 name: photosynthetic electron transport in plastoquinone namespace: biological_process is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009775 name: photosynthetic electron transport in cytochrome b6/f namespace: biological_process is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009776 name: photosynthetic electron transport in plastocyanin namespace: biological_process is_a: GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0009777 name: photosynthetic phosphorylation namespace: biological_process def: "Any metabolic process by which photosynthetic organisms use light energy to convert ADP to ATP without the concomitant reduction of dioxygen (O2) to water that occurs in phosphorylation." [ISBN:0198547684] synonym: "photosynthetic ATP synthesis" NARROW [] is_a: GO:0016310 ! phosphorylation relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009778 name: cyclic photosynthetic phosphorylation namespace: biological_process def: "ATP synthesis is driven by a proton gradient generated across the thylakoid membrane. Involves only photosystem I." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009779 name: noncyclic photosynthetic phosphorylation namespace: biological_process def: "ATP synthesis is linked to the transport of electrons from water to NADP+ with the production of NADPH and dioxygen (O2). Involves photosystem I and photosystem II." [ISBN:0198547684] is_a: GO:0009777 ! photosynthetic phosphorylation [Term] id: GO:0009780 name: photosynthetic NADP+ reduction namespace: biological_process def: "The process by which NADP+ is reduced to NADPH. The light reactions of photosynthesis use energy from photons to generate high-energy electrons. These electrons are used directly to reduce NADP+ to NADPH. NADPH is a relatively stable molecule and can pass on its hydrogen atom to other molecules in chemical reactions." [GOC:jid, ISBN:0716746840, ISBN:0816017360] is_a: GO:0006740 ! NADPH regeneration relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0009781 name: photosynthetic water oxidation namespace: biological_process def: "OBSOLETE. Processes by which a molecule of water is oxidized during photosynthesis. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:jid, ISBN:0716743663, ISBN:0816017360] comment: This term was made obsolete because it represents a molecular function. is_obsolete: true replaced_by: GO:0010242 [Term] id: GO:0009782 name: photosystem I antenna complex namespace: cellular_component def: "The antenna complex of photosystem I. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009522 ! photosystem I [Term] id: GO:0009783 name: photosystem II antenna complex namespace: cellular_component def: "The antenna complex of photosystem II. A photosystem has two closely linked components, an antenna containing light-absorbing pigments and a reaction center. Each antenna contains one or more light-harvesting complexes (LHCs)." [GOC:jid, ISBN:0716731363] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044436 ! thylakoid part relationship: part_of GO:0009523 ! photosystem II [Term] id: GO:0009784 name: transmembrane receptor histidine kinase activity namespace: molecular_function def: "A transmembrane receptor that perceives a stimulus and that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] subset: gosubset_prok is_a: GO:0004673 ! protein histidine kinase activity is_a: GO:0019199 ! transmembrane receptor protein kinase activity [Term] id: GO:0009785 name: blue light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of blue light by photoreceptor molecule, at a wavelength between 400nm and 470nm." [GOC:lr, GOC:sm] synonym: "blue light signalling pathway" EXACT [] is_a: GO:0030522 ! intracellular receptor mediated signaling pathway is_a: GO:0071483 ! cellular response to blue light [Term] id: GO:0009786 name: regulation of asymmetric cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of asymmetric cell division." [GOC:lr] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008356 ! asymmetric cell division relationship: regulates GO:0008356 ! asymmetric cell division [Term] id: GO:0009787 name: regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] synonym: "regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009738 ! abscisic acid mediated signaling pathway relationship: regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009788 name: negative regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction mediated by abscisic acid." [GOC:lr] synonym: "down regulation of abscisic acid mediated signaling" EXACT [] synonym: "down-regulation of abscisic acid mediated signaling" EXACT [] synonym: "downregulation of abscisic acid mediated signaling" EXACT [] synonym: "inhibition of abscisic acid mediated signaling" NARROW [] synonym: "negative regulation of abscisic acid mediated signalling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway is_a: GO:0035467 ! negative regulation of signaling pathway is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009738 ! abscisic acid mediated signaling pathway relationship: negatively_regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009789 name: positive regulation of abscisic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of abscisic acid mediated signal transduction." [GOC:lr] synonym: "activation of abscisic acid mediated signaling" NARROW [] synonym: "positive regulation of abscisic acid mediated signalling" EXACT [] synonym: "stimulation of abscisic acid mediated signaling" NARROW [] synonym: "up regulation of abscisic acid mediated signaling" EXACT [] synonym: "up-regulation of abscisic acid mediated signaling" EXACT [] synonym: "upregulation of abscisic acid mediated signaling" EXACT [] is_a: GO:0009787 ! regulation of abscisic acid mediated signaling pathway is_a: GO:0035468 ! positive regulation of signaling pathway is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009738 ! abscisic acid mediated signaling pathway relationship: positively_regulates GO:0009738 ! abscisic acid mediated signaling pathway [Term] id: GO:0009790 name: embryo development namespace: biological_process alt_id: GO:0009795 def: "The process whose specific outcome is the progression of an embryo from its formation until the end of its embryonic life stage. The end of the embryonic stage is organism-specific. For example, for mammals, the process would begin with zygote formation and end with birth. For insects, the process would begin at zygote formation and end with larval hatching. For plant zygotic embryos, this would be from zygote formation to the end of seed dormancy. For plant vegetative embryos, this would be from the initial determination of the cell or group of cells to form an embryo until the point when the embryo becomes independent of the parent plant." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] subset: goslim_generic subset: goslim_plant synonym: "embryogenesis" EXACT [] synonym: "embryogenesis and morphogenesis" BROAD [] synonym: "embryonal development" EXACT [] xref: Wikipedia:Embryogenesis is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009791 name: post-embryonic development namespace: biological_process def: "The process whose specific outcome is the progression of the organism over time, from the completion of embryonic development to the mature structure. See embryonic development." [GOC:go_curators] subset: goslim_plant is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009792 name: embryo development ending in birth or egg hatching namespace: biological_process def: "The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell." [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0009790 ! embryo development [Term] id: GO:0009793 name: embryo development ending in seed dormancy namespace: biological_process def: "The process whose specific outcome is the progression of the embryo over time, from zygote formation to the end of seed dormancy. An example of this process is found in Arabidopsis thaliana." [GOC:go_curators, GOC:mtg_sensu] synonym: "embryogenesis" BROAD [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009790 ! embryo development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009794 name: regulation of mitotic cell cycle, embryonic namespace: biological_process def: "Any process that modulates the frequency, rate or extent of replication and segregation of genetic material in the embryo." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "control of embryonic mitotic cell cycle progression" EXACT [] synonym: "embryonic mitotic cell cycle control" EXACT [] synonym: "embryonic mitotic cell cycle modulation" EXACT [] synonym: "embryonic mitotic cell cycle regulation" EXACT [] synonym: "embryonic mitotic cell cycle regulator" RELATED [] synonym: "modulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of embryonic mitotic cell cycle" EXACT [GOC:dph, GOC:tb] synonym: "regulation of embryonic mitotic cell cycle progression" EXACT [] synonym: "regulation of progression through embryonic mitotic cell cycle" EXACT [] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045448 ! mitotic cell cycle, embryonic relationship: regulates GO:0045448 ! mitotic cell cycle, embryonic [Term] id: GO:0009798 name: axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of a pattern along a line or around a point." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "axis determination" RELATED [] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009799 name: specification of symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism such that a similar arrangement in form and relationship of parts around a common axis, or around each side of a plane is created." [GOC:go_curators] synonym: "determination of symmetry" RELATED [GOC:dph] is_a: GO:0007389 ! pattern specification process [Term] id: GO:0009800 name: cinnamic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid anabolism" EXACT [] synonym: "cinnamic acid biosynthesis" EXACT [] synonym: "cinnamic acid formation" EXACT [] synonym: "cinnamic acid synthesis" EXACT [] synonym: "cinnamylic acid biosynthesis" EXACT [] synonym: "cinnamylic acid biosynthetic process" EXACT [] synonym: "phenylacrylic acid biosynthesis" EXACT [] synonym: "phenylacrylic acid biosynthetic process" EXACT [] synonym: "phenylpropenoic acid biosynthesis" EXACT [] synonym: "phenylpropenoic acid biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009801 name: cinnamic acid ester metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "cinnamic acid ester metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009802 name: cinnamic acid ester biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ester derivatives of cinnamic acid, phenylpropenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid ester anabolism" EXACT [] synonym: "cinnamic acid ester biosynthesis" EXACT [] synonym: "cinnamic acid ester formation" EXACT [] synonym: "cinnamic acid ester synthesis" EXACT [] synonym: "cinnamylic acid ester biosynthesis" EXACT [] synonym: "cinnamylic acid ester biosynthetic process" EXACT [] synonym: "phenylacrylic acid ester biosynthesis" EXACT [] synonym: "phenylacrylic acid ester biosynthetic process" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009801 ! cinnamic acid ester metabolic process relationship: part_of GO:0009803 ! cinnamic acid metabolic process [Term] id: GO:0009803 name: cinnamic acid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cinnamic acid, 3-phenyl-2-propenoic acid." [GOC:jl] subset: gosubset_prok synonym: "cinnamic acid metabolism" EXACT [] synonym: "cinnamylic acid metabolic process" EXACT [] synonym: "cinnamylic acid metabolism" EXACT [] synonym: "phenylacrylic acid metabolic process" EXACT [] synonym: "phenylacrylic acid metabolism" EXACT [] synonym: "phenylpropenoic acid metabolic process" EXACT [] synonym: "phenylpropenoic acid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0032787 ! monocarboxylic acid metabolic process [Term] id: GO:0009804 name: coumarin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "coumarin metabolism" EXACT [] xref: Reactome:211881 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:546515 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:546521 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:573558 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:573564 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:649840 "Coumarin is 7-hydroxylated by CYP2A13" xref: Reactome:649843 "Coumarin is 7-hydroxylated by CYP2A6" xref: Reactome:76453 "Coumarin is 7-hydroxylated by CYP2A6" is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0046483 ! heterocycle metabolic process [Term] id: GO:0009805 name: coumarin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of coumarins, a class of compounds derived from the phenylacrylic skeleton of cinnamic acids." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "coumarin anabolism" EXACT [] synonym: "coumarin biosynthesis" EXACT [] synonym: "coumarin formation" EXACT [] synonym: "coumarin synthesis" EXACT [] xref: MetaCyc:PWY-5176 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009804 ! coumarin metabolic process [Term] id: GO:0009806 name: lignan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] subset: gosubset_prok synonym: "lignan metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009807 name: lignan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignans, any member of a class of plant metabolites related to lignins. Lignans are usually found as phenylpropanoid dimers in which the phenylpropanoid units are linked tail to tail and thus having a 2,3 dibenzylbutane skeleton, but higher oligomers can also exist." [GOC:jl, PMID:10074466] subset: gosubset_prok synonym: "lignan anabolism" EXACT [] synonym: "lignan biosynthesis" EXACT [] synonym: "lignan formation" EXACT [] synonym: "lignan synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009806 ! lignan metabolic process [Term] id: GO:0009808 name: lignin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving lignins, a class of polymers of phenylpropanoid units." [GOC:lr, GOC:yl] subset: gosubset_prok synonym: "lignin metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009809 name: lignin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of lignins, a class of polymers formed by the dehydrogenetive radical polymerization of various phenylpropanoid monomers." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "lignin anabolism" EXACT [] synonym: "lignin biosynthesis" EXACT [] synonym: "lignin formation" EXACT [] synonym: "lignin synthesis" EXACT [] xref: MetaCyc:PWY-361 is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009808 ! lignin metabolic process [Term] id: GO:0009810 name: stilbene metabolic process namespace: biological_process def: "The chemical reactions and pathways involving stilbenes, a class of polyketides formed from a molecule of cinnamic acid and three molecules of malonyl-CoA." [ISBN:311011625] subset: gosubset_prok synonym: "stilbene metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process is_a: GO:0030638 ! polyketide metabolic process is_a: GO:0043449 ! cellular alkene metabolic process [Term] id: GO:0009811 name: stilbene biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of stilbenes, a class of polyketide compounds formed from cinnamic acid and three molecules of malonyl CoA." [GOC:tair_curators, ISBN:3110116251] subset: gosubset_prok synonym: "stilbene anabolism" EXACT [] synonym: "stilbene biosynthesis" EXACT [] synonym: "stilbene formation" EXACT [] synonym: "stilbene synthesis" EXACT [] is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009810 ! stilbene metabolic process is_a: GO:0030639 ! polyketide biosynthetic process is_a: GO:0043450 ! alkene biosynthetic process [Term] id: GO:0009812 name: flavonoid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving flavonoids, a group of water-soluble phenolic derivatives containing a flavan skeleton including flavones, flavonols and flavanoids, and anthocyanins." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "flavonoid metabolism" EXACT [] is_a: GO:0009698 ! phenylpropanoid metabolic process [Term] id: GO:0009813 name: flavonoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of flavonoids, a group of phenolic derivatives containing a flavan skeleton." [GOC:tair_curators, ISBN:0198547684] subset: gosubset_prok synonym: "flavonoid anabolism" EXACT [] synonym: "flavonoid biosynthesis" EXACT [] synonym: "flavonoid formation" EXACT [] synonym: "flavonoid synthesis" EXACT [] xref: MetaCyc:PWY1F-FLAVSYN xref: Wikipedia:Flavonoid is_a: GO:0009699 ! phenylpropanoid biosynthetic process is_a: GO:0009812 ! flavonoid metabolic process [Term] id: GO:0009814 name: defense response, incompatible interaction namespace: biological_process def: "A response of a plant to a pathogenic agent that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response incompatible interaction" EXACT [] synonym: "defence response to pathogen, incompatible interaction" EXACT [] synonym: "resistance response to pathogen" EXACT [] synonym: "response to pathogen (incompatible interaction)" EXACT [] is_a: GO:0045087 ! innate immune response is_a: GO:0051707 ! response to other organism [Term] id: GO:0009815 name: 1-aminocyclopropane-1-carboxylate oxidase activity namespace: molecular_function def: "Catalysis of the reaction: ascorbate + 1-aminocyclopropane-1-carboxylate + O2 = 2 H2O + ethene (ethylene) + L-dehydro-ascorbate + hydrocyanic acid + CO2." [EC:1.14.17.4, MetaCyc:ETHYL-RXN] synonym: "1-aminocyclopropane-1-carboxylate oxygenase (ethylene-forming)" EXACT [EC:1.14.17.4] synonym: "ACC oxidase activity" EXACT [] synonym: "aminocyclopropanecarboxylate oxidase activity" EXACT [EC:1.14.17.4] synonym: "ethene-forming enzyme" BROAD [] synonym: "ethylene-forming enzyme" BROAD [] xref: EC:1.14.17.4 xref: MetaCyc:ETHYL-RXN is_a: GO:0016641 ! oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor [Term] id: GO:0009816 name: defense response to bacterium, incompatible interaction namespace: biological_process def: "A response of an organism to a bacterium that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to bacterium, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacteria, incompatible interaction" EXACT [] synonym: "defence response to pathogenic bacterium, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic bacteria" EXACT [] synonym: "resistance response to pathogenic bacterium" EXACT [] synonym: "response to pathogenic bacteria (incompatible interaction)" EXACT [] synonym: "response to pathogenic bacterium (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042742 ! defense response to bacterium [Term] id: GO:0009817 name: defense response to fungus, incompatible interaction namespace: biological_process def: "A response of an organism to a fungus that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to fungus, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungi, incompatible interaction" EXACT [] synonym: "defence response to pathogenic fungus, incompatible interaction" EXACT [] synonym: "defense response to fungi, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic fungi" EXACT [] synonym: "resistance response to pathogenic fungus" EXACT [] synonym: "response to pathogenic fungi (incompatible interaction)" EXACT [] synonym: "response to pathogenic fungus (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0050832 ! defense response to fungus [Term] id: GO:0009818 name: defense response to protozoan, incompatible interaction namespace: biological_process def: "A response of an organism to a protozoan that prevents the occurrence or spread of disease." [GOC:lr] synonym: "defence response to pathogenic protozoa, incompatible interaction" EXACT [] synonym: "defence response to pathogenic protozoan, incompatible interaction" EXACT [] synonym: "defence response to protozoan, incompatible interaction" EXACT [] synonym: "resistance response to pathogenic protozoa" EXACT [] synonym: "resistance response to pathogenic protozoan" EXACT [] synonym: "response to pathogenic protozoa (incompatible interaction)" EXACT [] synonym: "response to pathogenic protozoan (incompatible interaction)" EXACT [] is_a: GO:0009814 ! defense response, incompatible interaction is_a: GO:0042832 ! defense response to protozoan [Term] id: GO:0009819 name: drought recovery namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, gene expression, enzyme production, etc.) as a result of prolonged deprivation of water that restores that organism to a normal (non-stressed) condition." [GOC:lr] synonym: "drought tolerance" RELATED [] is_a: GO:0009414 ! response to water deprivation [Term] id: GO:0009820 name: alkaloid metabolic process namespace: biological_process def: "The chemical reactions and pathways involving alkaloids, nitrogen containing natural products which are not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "alkaloid metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process is_a: GO:0019748 ! secondary metabolic process [Term] id: GO:0009821 name: alkaloid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of alkaloids, nitrogen-containing natural products which are not otherwise classified as nonprotein amino acids, amines, peptides, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones, or primary metabolite (such as purine or pyrimidine bases)." [EC:1.1.1.51, GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "alkaloid anabolism" EXACT [] synonym: "alkaloid biosynthesis" EXACT [] synonym: "alkaloid formation" EXACT [] synonym: "alkaloid synthesis" EXACT [] xref: UM-BBD_enzymeID:e0711 is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0009822 name: alkaloid catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of alkaloids, nitrogen containing natural products not otherwise classified as peptides, nonprotein amino acids, amines, cyanogenic glycosides, glucosinolates, cofactors, phytohormones or primary metabolites (such as purine or pyrimidine bases)." [GOC:lr, ISBN:01221146743] subset: gosubset_prok synonym: "alkaloid breakdown" EXACT [] synonym: "alkaloid catabolism" EXACT [] synonym: "alkaloid degradation" EXACT [] is_a: GO:0009820 ! alkaloid metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0009823 name: cytokinin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cytokinins, a class of adenine-derived compounds that can function in plants as plant growth regulators." [GOC:lr] subset: gosubset_prok synonym: "cytokinin breakdown" EXACT [] synonym: "cytokinin catabolism" EXACT [] synonym: "cytokinin degradation" EXACT [] is_a: GO:0009690 ! cytokinin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009824 name: adenylate dimethylallyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: delta(2)-isopentenyl diphosphate + AMP = diphosphate + N6-(delta(2)-isopentenyl)adenosine 5'-monophosphate." [EC:2.5.1.27] synonym: "2-isopentenyl-diphosphate:AMP 2-isopentenyltransferase activity" EXACT [] synonym: "2-isopentenyl-diphosphate:AMP delta2-isopentenyltransferase activity" EXACT [EC:2.5.1.27] synonym: "adenylate isopentenyltransferase activity" EXACT [] synonym: "cytokinin synthase activity" EXACT [] synonym: "dimethylallyl-diphosphate:AMP dimethylallyltransferase activity" EXACT [EC:2.5.1.27] synonym: "isopentenyltransferase activity" EXACT [] xref: EC:2.5.1.27 is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0009825 name: multidimensional cell growth namespace: biological_process def: "The process by which a cell irreversibly increases in size in two or three [spatial] dimensions or along two or three axes." [ISBN:0943088399] subset: gosubset_prok synonym: "cell growth in three dimensions" EXACT [] synonym: "cell growth in two dimensions" NARROW [] is_a: GO:0016049 ! cell growth [Term] id: GO:0009826 name: unidimensional cell growth namespace: biological_process def: "The process by which a cell irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell." [ISBN:0943088399] subset: gosubset_prok synonym: "cell elongation" NARROW [] synonym: "cell growth along one axis" EXACT [] synonym: "cell growth in one dimension" EXACT [] synonym: "cell morphogenesis by unidimensional growth" EXACT [GOC:dph, GOC:tb] synonym: "polar cell growth" EXACT [] synonym: "polarized cell growth" EXACT [] is_a: GO:0000902 ! cell morphogenesis is_a: GO:0016049 ! cell growth is_a: GO:0060560 ! developmental growth involved in morphogenesis [Term] id: GO:0009827 name: plant-type cell wall modification namespace: biological_process def: "The series of events leading to chemical and structural alterations of an existing cellulose and pectin-containing cell wall that can result in loosening, increased extensibility or disassembly. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall modification" EXACT [] is_a: GO:0009664 ! plant-type cell wall organization is_a: GO:0042545 ! cell wall modification [Term] id: GO:0009828 name: plant-type cell wall loosening namespace: biological_process def: "The series of events causing chemical and structural alterations of an existing cellulose and pectin-containing cell wall that results in greater extensibility of the wall. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing cell wall loosening" EXACT [] is_a: GO:0009827 ! plant-type cell wall modification [Term] id: GO:0009829 name: cell wall modification involved in ripening namespace: biological_process def: "The series of events resulting in chemical or structural alterations of existing cell walls that contribute to ripening." [GOC:lr] synonym: "cell wall modification during ripening" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification relationship: part_of GO:0009835 ! ripening [Term] id: GO:0009830 name: cell wall modification involved in abscission namespace: biological_process def: "A cellular process that results in the breakdown of the cell wall that contributes to the process of abscission." [GOC:dph, GOC:lr, GOC:sdb_2009, GOC:tb] synonym: "cell wall modification during abscission" RELATED [GOC:dph, GOC:tb] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0060871 ! cellular cell wall disassembly relationship: part_of GO:0009838 ! abscission [Term] id: GO:0009831 name: plant-type cell wall modification involved in multidimensional cell growth namespace: biological_process def: "The series of events that occur during cell growth that result in chemical or structural changes to existing cell walls of the type composed chiefly of cellulose and pectin. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cell wall modification during cell expansion" BROAD [] synonym: "cellulose and pectin-containing cell wall modification during multidimensional cell growth" RELATED [] is_a: GO:0009827 ! plant-type cell wall modification is_a: GO:0042547 ! cell wall modification involved in multidimensional cell growth [Term] id: GO:0009832 name: plant-type cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the cellulose and pectin-containing cell wall. An example of this is found in Arabidopsis thaliana." [GOC:go_curators, GOC:lr, GOC:mtg_sensu] synonym: "cell wall anabolism" BROAD [] synonym: "cell wall assembly" BROAD [] synonym: "cell wall biosynthetic process" BROAD [] synonym: "cell wall formation" BROAD [] synonym: "cell wall synthesis" BROAD [] synonym: "cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0042546 ! cell wall biogenesis is_a: GO:0071669 ! plant-type cell wall organization or biogenesis [Term] id: GO:0009833 name: primary cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cellulose and pectin-containing cell walls that form adjacent to the middle lamella following cell division and during cell expansion. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing primary cell wall biogenesis" EXACT [] synonym: "plant-type primary cell wall biogenesis" EXACT [] synonym: "primary cell wall anabolism" BROAD [] synonym: "primary cell wall biosynthetic process" BROAD [] synonym: "primary cell wall formation" BROAD [] synonym: "primary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009834 name: secondary cell wall biogenesis namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of inextensible cellulose and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall after cell expansion is complete. An example of this is found in Arabidopsis thaliana." [GOC:lr, GOC:mtg_sensu] synonym: "cellulose and pectin-containing secondary cell wall biogenesis" EXACT [] synonym: "plant-type secondary cell wall biogenesis" EXACT [] synonym: "secondary cell wall anabolism" BROAD [] synonym: "secondary cell wall biosynthetic process" BROAD [] synonym: "secondary cell wall formation" BROAD [] synonym: "secondary cell wall synthesis" BROAD [] is_a: GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009835 name: ripening namespace: biological_process def: "The series of events causing changes in one or more characteristics of a fruit (color, aroma, flavor, texture, hardness, cell wall structure) to make it more attractive to animals and/or aid in seed dispersal." [GOC:lr] subset: goslim_plant xref: Wikipedia:Ripening is_a: GO:0048608 ! reproductive structure development relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009836 name: ripening, climacteric namespace: biological_process def: "A ripening process that involves a burst of respiration and ethylene (ethene) evolution at the onset." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! ripening [Term] id: GO:0009837 name: ripening, non-climacteric namespace: biological_process def: "A ripening process that does not involve a respiratory burst." [GOC:lr, ISBN:0521587840] is_a: GO:0009835 ! ripening [Term] id: GO:0009838 name: abscission namespace: biological_process def: "The controlled shedding of a body part." [ISBN:0140514031] subset: goslim_plant xref: Wikipedia:Abscission is_a: GO:0032502 ! developmental process relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0009839 name: SCF complex substrate recognition subunit namespace: cellular_component def: "OBSOLETE. The portion of the SCF ubiquitin ligase complex that contains sites required for recognition (and recruitment) of the substrate to the complex." [PMID:11790542, PMID:9857172] comment: This term was made obsolete because it represents a single gene product and not a complex. is_obsolete: true replaced_by: GO:0019005 [Term] id: GO:0009840 name: chloroplastic endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the chloroplast." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0044434 ! chloroplast part intersection_of: GO:0009368 ! endopeptidase Clp complex intersection_of: part_of GO:0009570 ! chloroplast stroma relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0009841 name: mitochondrial endopeptidase Clp complex namespace: cellular_component def: "A Clp endopeptidase complex located in the mitochondrion." [GOC:mah] is_a: GO:0009368 ! endopeptidase Clp complex is_a: GO:0044429 ! mitochondrial part intersection_of: GO:0009368 ! endopeptidase Clp complex intersection_of: part_of GO:0005739 ! mitochondrion relationship: part_of GO:0005759 ! mitochondrial matrix [Term] id: GO:0009842 name: cyanelle namespace: cellular_component def: "A plastid that contains unstacked, phycobilisome-bearing thylakoid membranes and is surrounded by a peptidoglycan layer as well as a double membrane. Cyanelles are characteristic of algae in the class Glaucophyta, and may represent an ancestral form of plastid." [ISBN:052131687, ISBN:1402001894] subset: gosubset_prok synonym: "cyanoplast" EXACT [ISBN:1402001894] synonym: "muroplast" EXACT [ISBN:1402001894] is_a: GO:0009536 ! plastid [Term] id: GO:0009843 name: cyanelle thylakoid namespace: cellular_component def: "A thylakoid found in a cyanelle, which is a type of plastid found in certain algae. The cyanelle contains a photosynthetic membrane resembling that of cyanobacteria." [GOC:lr, GOC:mah, GOC:mtg_sensu] subset: gosubset_prok is_a: GO:0031976 ! plastid thylakoid intersection_of: GO:0009579 ! thylakoid intersection_of: part_of GO:0009842 ! cyanelle relationship: part_of GO:0009842 ! cyanelle [Term] id: GO:0009844 name: germination namespace: biological_process alt_id: GO:0009565 def: "OBSOLETE. The physiological and developmental changes by a seed, spore, pollen grain (microspore), or zygote that occur after release from dormancy, and encompassing events prior to and including the first visible indications of growth." [GOC:lr] comment: This term was made obsolete because it is a grouping term without biological significance. is_obsolete: true [Term] id: GO:0009845 name: seed germination namespace: biological_process def: "The physiological and developmental changes that occur in a seed commencing with water uptake (imbibition) and terminating with the elongation of the embryonic axis." [PMID:8281041] xref: Wikipedia:Germination#Seed_germination is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0090351 ! seedling development [Term] id: GO:0009846 name: pollen germination namespace: biological_process def: "The physiological and developmental changes that occur in a heterosporous plant pollen grain, beginning with hydration and terminating with the emergence of the pollen tube through the aperture." [GOC:lr, http://www.bio.uu.nl, ISBN:0943088399] is_a: GO:0032501 ! multicellular organismal process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009847 name: spore germination namespace: biological_process def: "The physiological and developmental changes that occur in a spore following release from dormancy up to the earliest signs of growth (e.g. emergence from a spore wall)." [GOC:lr] subset: gosubset_prok is_a: GO:0032502 ! developmental process [Term] id: GO:0009848 name: indoleacetic acid biosynthetic process via tryptophan namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indole-3-acetic acid that occurs through metabolism of L-tryptophan." [GOC:lm, GOC:lr, PMID:10375566] subset: gosubset_prok synonym: "IAA biosynthetic process via tryptophan" EXACT [] synonym: "indoleacetic acid anabolism via tryptophan" EXACT [] synonym: "indoleacetic acid formation via tryptophan" EXACT [] synonym: "indoleacetic acid synthesis via tryptophan" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0006568 ! tryptophan metabolic process is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009849 name: tryptophan-independent indoleacetic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of indoleacetic acid, independent of tryptophan." [GOC:go_curators, GOC:lm, GOC:lr, PMID:10375566] subset: gosubset_prok synonym: "indoleacetic acid biosynthesis, tryptophan-independent" EXACT [] synonym: "indoleacetic acid biosynthetic process, tryptophan-independent" EXACT [] synonym: "tryptophan-independent IAA biosynthetic process" EXACT [] synonym: "tryptophan-independent indoleacetic acid anabolism" EXACT [] synonym: "tryptophan-independent indoleacetic acid biosynthesis" EXACT [] synonym: "tryptophan-independent indoleacetic acid formation" EXACT [] synonym: "tryptophan-independent indoleacetic acid synthesis" EXACT [] xref: MetaCyc:PWY-581 is_a: GO:0009684 ! indoleacetic acid biosynthetic process [Term] id: GO:0009850 name: auxin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lr] subset: gosubset_prok synonym: "auxin metabolism" EXACT [] is_a: GO:0042445 ! hormone metabolic process is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0009851 name: auxin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of auxins, plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0122146743] subset: gosubset_prok synonym: "auxin anabolism" EXACT [] synonym: "auxin biosynthesis" EXACT [] synonym: "auxin formation" EXACT [] synonym: "auxin synthesis" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042446 ! hormone biosynthetic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0009852 name: auxin catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of auxins, a group of plant hormones that regulate aspects of plant growth." [GOC:lm, GOC:lr, ISBN:0198547684] subset: gosubset_prok synonym: "auxin breakdown" EXACT [] synonym: "auxin catabolism" EXACT [] synonym: "auxin degradation" EXACT [] is_a: GO:0009850 ! auxin metabolic process is_a: GO:0042447 ! hormone catabolic process [Term] id: GO:0009853 name: photorespiration namespace: biological_process def: "A light-dependent catabolic process occurring concomitantly with photosynthesis in plants (especially C3 plants) whereby dioxygen (O2) is consumed and carbon dioxide (CO2) is evolved. The substrate is glycolate formed in large quantities in chloroplasts from 2-phosphoglycolate generated from ribulose 1,5-bisphosphate by the action of ribulose-bisphosphate carboxylase; the glycolate enters the peroxisomes where it is converted by glycolate oxidase to glyoxylate which undergoes transamination to glycine. This then passes into the mitochondria where it is decarboxylated forming one molecule of serine for every two molecules of glycine. This pathway also exists in photosynthetic bacteria." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] subset: gosubset_prok xref: MetaCyc:PWY-181 xref: Wikipedia:Photorespiration is_a: GO:0043094 ! cellular metabolic compound salvage [Term] id: GO:0009854 name: oxidative photosynthetic carbon pathway namespace: biological_process def: "The reactions of the C2 pathway bring about the metabolic conversion of two molecules of 2-phosphoglycolate to one molecule of 3-phosphoglycerate, which can be used by the C3 cycle, and one molecule of carbon dioxide (CO2)." [ISBN:00943088399] subset: gosubset_prok is_a: GO:0043094 ! cellular metabolic compound salvage relationship: part_of GO:0009853 ! photorespiration [Term] id: GO:0009855 name: determination of bilateral symmetry namespace: biological_process def: "The establishment of an organism's body plan or part of an organism with respect to a single longitudinal plane. The pattern can either be symmetric, such that the halves are mirror images, or asymmetric where the pattern deviates from this symmetry." [GOC:go_curators] is_a: GO:0009799 ! specification of symmetry [Term] id: GO:0009856 name: pollination namespace: biological_process def: "The cascade of biological processes occurring in plants beginning when the pollen lands on the stigma and continuing up to, but not including, fertilization, as defined by sperm-central cell fusion." [GOC:tb, PMID:10973091] subset: goslim_plant xref: Wikipedia:Pollination is_a: GO:0022414 ! reproductive process is_a: GO:0051704 ! multi-organism process [Term] id: GO:0009858 name: compatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in unimpeded growth of the pollen tube through the stigma and style." [GOC:lr, ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009859 name: pollen hydration namespace: biological_process def: "The process by which water is taken up by pollen." [GOC:lr] is_a: GO:0006833 ! water transport relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009860 name: pollen tube growth namespace: biological_process def: "Growth of pollen via tip extension of the intine wall." [ISBN:00943088399] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009932 ! cell tip growth is_a: GO:0048588 ! developmental cell growth is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009861 name: jasmonic acid and ethylene-dependent systemic resistance namespace: biological_process def: "The jasmonic acid and ethylene (ethene) dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen." [GOC:jy, PMID:10234273] synonym: "jasmonic acid and ethene-dependent systemic resistance" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance" EXACT [] is_a: GO:0009611 ! response to wounding is_a: GO:0009814 ! defense response, incompatible interaction [Term] id: GO:0009862 name: systemic acquired resistance, salicylic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by salicylic acid involved in systemic acquired resistance." [GOC:jy] synonym: "salicylic acid mediated signaling pathway (systemic acquired resistance)" EXACT [] synonym: "systemic acquired resistance, salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0009863 ! salicylic acid mediated signaling pathway relationship: part_of GO:0009627 ! systemic acquired resistance [Term] id: GO:0009863 name: salicylic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by salicylic acid." [GOC:jy] synonym: "salicylic acid mediated signalling pathway" EXACT [] is_a: GO:0023033 ! signaling pathway is_a: GO:0071446 ! cellular response to salicylic acid stimulus [Term] id: GO:0009864 name: induced systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in induced systemic resistance." [GOC:jy] synonym: "induced systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (induced systemic resistance)" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0009867 ! jasmonic acid mediated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009865 name: pollen tube adhesion namespace: biological_process def: "The process by which the pollen tube adheres to cells of the stigma and style." [GOC:tair_curators, PMID:12602877] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0009875 ! pollen-pistil interaction relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0009866 name: induced systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in induced systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (induced systemic resistance)" EXACT [] synonym: "induced systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "induced systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "induced systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0009873 ! ethylene mediated signaling pathway relationship: part_of GO:0009682 ! induced systemic resistance [Term] id: GO:0009867 name: jasmonic acid mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by jasmonic acid." [GOC:jy] synonym: "jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0023033 ! signaling pathway is_a: GO:0071395 ! cellular response to jasmonic acid stimulus [Term] id: GO:0009868 name: jasmonic acid and ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by jasmonic acid involved in jasmonic acid/ethylene (ethene) dependent systemic resistance." [GOC:jy] synonym: "jasmonic acid and ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, jasmonic acid mediated signalling pathway" EXACT [] is_a: GO:0009867 ! jasmonic acid mediated signaling pathway is_a: GO:0032260 ! response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009869 name: incompatible pollen-pistil interaction namespace: biological_process def: "OBSOLETE. An interaction between a pollen grain and pistil that results in inhibition of pollen germination/growth." [PMID:10375566] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009870 name: defense response signaling pathway, resistance gene-dependent namespace: biological_process def: "A series of molecular signals that depends upon R-genes and is activated during defense response." [GOC:jy, GOC:mah, PMID:11418339] synonym: "defence response signaling pathway, resistance gene-dependent" EXACT [] synonym: "defence response signalling pathway, resistance gene-dependent" EXACT [] synonym: "defense response signalling pathway, resistance gene-dependent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0023033 ! signaling pathway [Term] id: GO:0009871 name: jasmonic acid and ethylene-dependent systemic resistance, ethylene mediated signaling pathway namespace: biological_process def: "The series of molecular signals mediated by ethylene (ethene) involved in jasmonic acid/ethylene dependent systemic resistance." [GOC:jy] synonym: "ethene mediated signaling pathway (jasmonic acid/ethene-dependent systemic resistance)" EXACT [] synonym: "ethylene mediated signaling pathway (jasmonic acid/ethylene-dependent systemic resistance)" EXACT [] synonym: "jasmonic acid and ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethene-dependent systemic resistance, ethene mediated signalling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signaling pathway" EXACT [] synonym: "jasmonic acid/ethylene-dependent systemic resistance, ethylene mediated signalling pathway" EXACT [] is_a: GO:0009873 ! ethylene mediated signaling pathway relationship: part_of GO:0009861 ! jasmonic acid and ethylene-dependent systemic resistance [Term] id: GO:0009872 name: gametophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009873 name: ethylene mediated signaling pathway namespace: biological_process def: "A series of molecular signals mediated by ethylene (ethene)." [GOC:jy] synonym: "ethene mediated signaling pathway" EXACT [] synonym: "ethene mediated signalling pathway" EXACT [] synonym: "ethylene mediated signalling pathway" EXACT [] is_a: GO:0000160 ! two-component signal transduction system (phosphorelay) is_a: GO:0009755 ! hormone-mediated signaling pathway is_a: GO:0071369 ! cellular response to ethylene stimulus [Term] id: GO:0009874 name: sporophytic self-incompatibility namespace: biological_process def: "OBSOLETE. A mechanism that functions to prevent self-fertilization in flowering plants that is determined by the diploid genotype of the parent plant. In sporophytic incompatibility the pollen does not germinate, consequently fertilization does not take place." [ISBN:0387987819] comment: This term was made obsolete because it represents a phenotype. is_obsolete: true [Term] id: GO:0009875 name: pollen-pistil interaction namespace: biological_process def: "The interaction between a pollen grain and pistil." [GOC:go_curators] subset: goslim_plant is_a: GO:0007154 ! cell communication is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0009876 name: pollen adhesion namespace: biological_process def: "The process by which pollen deposited on the stigma adheres to cells of the stigma." [GOC:tair_curators] is_a: GO:0016337 ! cell-cell adhesion is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0009875 ! pollen-pistil interaction [Term] id: GO:0009877 name: nodulation namespace: biological_process def: "The formation of nitrogen-fixing root nodules on plant roots." [SP_KW:KW-0536] is_a: GO:0044403 ! symbiosis, encompassing mutualism through parasitism [Term] id: GO:0009878 name: nodule morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the nodule are generated and organized. Morphogenesis pertains to the creation of form." [GOC:jid] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0009877 ! nodulation [Term] id: GO:0009879 name: determination of radial symmetry namespace: biological_process def: "The establishment of an organism's body plan or a part of an organism such that it is symmetric around a central axis." [GOC:go_curators] is_a: GO:0009799 ! specification of symmetry relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009880 name: embryonic pattern specification namespace: biological_process def: "The process that results in the patterns of cell differentiation that will arise in an embryo." [GOC:go_curators, ISBN:0521436125] synonym: "embryonic pattern biosynthesis" BROAD [] synonym: "embryonic pattern formation" BROAD [] synonym: "ventral/lateral system" RELATED [] is_a: GO:0007389 ! pattern specification process relationship: part_of GO:0009790 ! embryo development [Term] id: GO:0009881 name: photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to incidental electromagnetic radiation, particularly visible light. The response may involve a change in conformation." [GOC:ai, GOC:go_curators] subset: gosubset_prok synonym: "blue-sensitive opsin" NARROW [] synonym: "green-sensitive opsin" NARROW [] synonym: "long-wave-sensitive opsin" NARROW [] synonym: "opsin" NARROW [] synonym: "red-sensitive opsin" NARROW [] synonym: "short-wave-sensitive opsin" NARROW [] synonym: "UV-sensitive opsin" NARROW [] synonym: "violet-sensitive opsin" NARROW [] is_a: GO:0004872 ! receptor activity [Term] id: GO:0009882 name: blue light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 400-470nm. The response may involve a change in conformation." [GOC:tb] subset: gosubset_prok is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009785 ! blue light signaling pathway [Term] id: GO:0009883 name: red or far-red light photoreceptor activity namespace: molecular_function def: "The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660-730nm. The response may involve a change in conformation." [GOC:lr] synonym: "red/far-red light photoreceptor activity" EXACT [] is_a: GO:0009881 ! photoreceptor activity relationship: part_of GO:0009585 ! red, far-red light phototransduction [Term] id: GO:0009884 name: cytokinin receptor activity namespace: molecular_function def: "Combining with a cytokinin to initiate a change in cell activity." [GOC:lr] is_a: GO:0004888 ! transmembrane receptor activity relationship: part_of GO:0009736 ! cytokinin mediated signaling pathway [Term] id: GO:0009885 name: transmembrane histidine kinase cytokinin receptor activity namespace: molecular_function def: "A transmembrane receptor of cytokinins that produces a molecular signal via phosphotransfer at histidine residues." [GOC:lr] is_a: GO:0009784 ! transmembrane receptor histidine kinase activity is_a: GO:0009884 ! cytokinin receptor activity [Term] id: GO:0009886 name: post-embryonic morphogenesis namespace: biological_process def: "The process, occurring after embryonic development, by which anatomical structures are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] synonym: "post-embryonic morphogenesis of an anatomical structure" EXACT [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0009791 ! post-embryonic development [Term] id: GO:0009887 name: organ morphogenesis namespace: biological_process def: "Morphogenesis of an organ. An organ is defined as a tissue or set of tissues that work together to perform a specific function or functions. Morphogenesis is the process by which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions." [GOC:dgh, GOC:go_curators, ISBN:0471245208, ISBN:0721662544 "Dorland's Illustrated Medical Dictionary"] synonym: "histogenesis and organogenesis" BROAD [] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048513 ! organ development [Term] id: GO:0009888 name: tissue development namespace: biological_process def: "The process whose specific outcome is the progression of a tissue over time, from its formation to the mature structure." [ISBN:0471245208] synonym: "histogenesis" EXACT [] synonym: "histogenesis and organogenesis" BROAD [] xref: Wikipedia:Histogenesis is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048513 ! organ development [Term] id: GO:0009889 name: regulation of biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of anabolism" EXACT [] synonym: "regulation of biosynthesis" EXACT [] synonym: "regulation of formation" EXACT [] synonym: "regulation of synthesis" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009058 ! biosynthetic process relationship: regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009890 name: negative regulation of biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the rate of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of biosynthetic process" EXACT [] synonym: "down-regulation of biosynthetic process" EXACT [] synonym: "downregulation of biosynthetic process" EXACT [] synonym: "inhibition of biosynthetic process" NARROW [] synonym: "negative regulation of anabolism" EXACT [] synonym: "negative regulation of biosynthesis" EXACT [] synonym: "negative regulation of formation" EXACT [] synonym: "negative regulation of synthesis" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009892 ! negative regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009058 ! biosynthetic process relationship: negatively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009891 name: positive regulation of biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of biosynthetic process" NARROW [] synonym: "positive regulation of anabolism" EXACT [] synonym: "positive regulation of biosynthesis" EXACT [] synonym: "positive regulation of formation" EXACT [] synonym: "positive regulation of synthesis" EXACT [] synonym: "stimulation of biosynthetic process" NARROW [] synonym: "up regulation of biosynthetic process" EXACT [] synonym: "up-regulation of biosynthetic process" EXACT [] synonym: "upregulation of biosynthetic process" EXACT [] is_a: GO:0009889 ! regulation of biosynthetic process is_a: GO:0009893 ! positive regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009058 ! biosynthetic process relationship: positively_regulates GO:0009058 ! biosynthetic process [Term] id: GO:0009892 name: negative regulation of metabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of metabolic process" EXACT [] synonym: "down-regulation of metabolic process" EXACT [] synonym: "downregulation of metabolic process" EXACT [] synonym: "inhibition of metabolic process" NARROW [] synonym: "negative regulation of metabolism" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048519 ! negative regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008152 ! metabolic process relationship: negatively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009893 name: positive regulation of metabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways within a cell or an organism." [GOC:go_curators] subset: gosubset_prok synonym: "activation of metabolic process" NARROW [] synonym: "positive regulation of metabolism" EXACT [] synonym: "stimulation of metabolic process" NARROW [] synonym: "up regulation of metabolic process" EXACT [] synonym: "up-regulation of metabolic process" EXACT [] synonym: "upregulation of metabolic process" EXACT [] is_a: GO:0019222 ! regulation of metabolic process is_a: GO:0048518 ! positive regulation of biological process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0008152 ! metabolic process relationship: positively_regulates GO:0008152 ! metabolic process [Term] id: GO:0009894 name: regulation of catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "regulation of breakdown" EXACT [] synonym: "regulation of catabolism" EXACT [] synonym: "regulation of degradation" EXACT [] is_a: GO:0019222 ! regulation of metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009056 ! catabolic process relationship: regulates GO:0009056 ! catabolic process [Term] id: GO:0009895 name: negative regulation of catabolic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "down regulation of catabolic process" EXACT [] synonym: "down-regulation of catabolic process" EXACT [] synonym: "downregulation of catabolic process" EXACT [] synonym: "inhibition of catabolic process" NARROW [] synonym: "negative regulation of breakdown" EXACT [] synonym: "negative regulation of catabolism" EXACT [] synonym: "negative regulation of degradation" EXACT [] is_a: GO:0009892 ! negative regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009056 ! catabolic process relationship: negatively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009896 name: positive regulation of catabolic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances." [GOC:go_curators] subset: gosubset_prok synonym: "activation of catabolic process" NARROW [] synonym: "positive regulation of breakdown" EXACT [] synonym: "positive regulation of catabolism" EXACT [] synonym: "positive regulation of degradation" EXACT [] synonym: "stimulation of catabolic process" NARROW [] synonym: "up regulation of catabolic process" EXACT [] synonym: "up-regulation of catabolic process" EXACT [] synonym: "upregulation of catabolic process" EXACT [] is_a: GO:0009893 ! positive regulation of metabolic process is_a: GO:0009894 ! regulation of catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009056 ! catabolic process relationship: positively_regulates GO:0009056 ! catabolic process [Term] id: GO:0009897 name: external side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that is opposite to the side that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] synonym: "outer surface of cytoplasmic membrane" EXACT [] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009898 name: internal side of plasma membrane namespace: cellular_component def: "The side of the plasma membrane that faces the cytoplasm." [GOC:tb] subset: gosubset_prok synonym: "juxtamembrane" BROAD [] is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009899 name: ent-kaurene synthase activity namespace: molecular_function def: "Catalysis of the reaction: ent-copalyl diphosphate = ent-kaurene + diphosphate." [EC:4.2.3.19, ISBN:0943088399] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing)" EXACT [EC:4.2.3.19] synonym: "ent-copalyl-diphosphate diphosphate-lyase (cyclizing, ent-kaurene-forming)" EXACT [EC:4.2.3.19] synonym: "ent-kaurene synthase B activity" NARROW [EC:4.2.3.19] synonym: "ent-kaurene synthetase B activity" NARROW [EC:4.2.3.19] xref: EC:4.2.3.19 xref: MetaCyc:4.2.3.19-RXN is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0009900 name: dehiscence namespace: biological_process def: "The opening of an anther, fruit or other structure, which permits the escape of reproductive bodies contained within it." [ISBN:0879015322] xref: Wikipedia:Dehiscence_(botany) is_a: GO:0048609 ! reproductive process in a multicellular organism [Term] id: GO:0009901 name: anther dehiscence namespace: biological_process def: "The dehiscence of an anther to release the pollen grains contained within it." [GOC:tb] is_a: GO:0009900 ! dehiscence relationship: part_of GO:0048653 ! anther development [Term] id: GO:0009902 name: chloroplast relocation namespace: biological_process def: "The process by which chloroplasts in photosynthetic cells migrate toward illuminated sites to optimize photosynthesis and move away from excessively illuminated areas to protect the photosynthetic machinery." [PMID:11309623] synonym: "chloroplast movement" EXACT [GOC:tb, PMID:18715957] is_a: GO:0009658 ! chloroplast organization is_a: GO:0051667 ! establishment of plastid localization [Term] id: GO:0009903 name: chloroplast avoidance movement namespace: biological_process def: "The relocation process by which chloroplasts in photosynthetic cells avoid strong light and move away from it in order to preserve the photosynthetic machinery." [GOC:tb, PMID:11978863] synonym: "high-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009904 name: chloroplast accumulation movement namespace: biological_process def: "The relocation process by which chloroplasts in photosynthetic cells move toward a brighter area in a cell to optimize photosynthesis." [GOC:tb, PMID:11978863] synonym: "low-fluence-rate response" RELATED [] is_a: GO:0009902 ! chloroplast relocation [Term] id: GO:0009905 name: ent-copalyl diphosphate synthase activity namespace: molecular_function def: "Catalysis of the reaction: geranylgeranyl diphosphate = ent-copalyl diphosphate." [EC:5.5.1.13, ISBN:0943088399] synonym: "diterpene cyclase activity" BROAD [] synonym: "ent-copalyl-diphosphate lyase (decyclizing)" EXACT [EC:5.5.1.13] synonym: "ent-kaurene synthase A activity" NARROW [EC:5.5.1.13] synonym: "ent-kaurene synthetase A activity" NARROW [EC:5.5.1.13] xref: EC:5.5.1.13 xref: MetaCyc:5.5.1.13-RXN is_a: GO:0016872 ! intramolecular lyase activity [Term] id: GO:0009906 name: response to photoperiod, blue light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a blue light photoperiod stimulus. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009637 ! response to blue light is_a: GO:0009648 ! photoperiodism [Term] id: GO:0009907 name: response to photoperiod, red light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light photoperiod stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm." [GOC:go_curators, GOC:mtg_far_red] is_a: GO:0009648 ! photoperiodism is_a: GO:0010114 ! response to red light [Term] id: GO:0009908 name: flower development namespace: biological_process alt_id: GO:0048409 def: "The process whose specific outcome is the progression of the flower over time, from its formation to the mature structure. The flower is the reproductive structure in a plant, and its development begins with the transition of the vegetative or inflorescence meristem into a floral meristem." [GOC:tb, ISBN:0879015322] subset: goslim_plant is_a: GO:0009791 ! post-embryonic development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0009909 name: regulation of flower development namespace: biological_process def: "Any process that modulates the frequency, rate or extent of flower development." [GOC:go_curators] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009908 ! flower development relationship: regulates GO:0009908 ! flower development [Term] id: GO:0009910 name: negative regulation of flower development namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "down regulation of flower development" EXACT [] synonym: "down-regulation of flower development" EXACT [] synonym: "downregulation of flower development" EXACT [] synonym: "inhibition of flower development" NARROW [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048581 ! negative regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009908 ! flower development relationship: negatively_regulates GO:0009908 ! flower development [Term] id: GO:0009911 name: positive regulation of flower development namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of flower development." [GOC:go_curators] synonym: "activation of flower development" NARROW [] synonym: "stimulation of flower development" NARROW [] synonym: "up regulation of flower development" EXACT [] synonym: "up-regulation of flower development" EXACT [] synonym: "upregulation of flower development" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0048582 ! positive regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009908 ! flower development relationship: positively_regulates GO:0009908 ! flower development [Term] id: GO:0009912 name: auditory receptor cell fate commitment namespace: biological_process def: "The process by which the cellular identity of auditory hair cells is acquired and determined." [GOC:lr] synonym: "auditory hair cell fate commitment" EXACT [] is_a: GO:0060120 ! inner ear receptor cell fate commitment relationship: part_of GO:0042491 ! auditory receptor cell differentiation [Term] id: GO:0009913 name: epidermal cell differentiation namespace: biological_process alt_id: GO:0043355 def: "The process whereby a relatively unspecialized cell acquires specialized features of an epidermal cell, any of the cells making up the epidermis." [GOC:dph, GOC:go_curators, GOC:mtg_sensu, GOC:sdb_2009, GOC:tb] synonym: "hypodermal cell differentiation" RELATED [GOC:kmv, GOC:rk] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0008544 ! epidermis development [Term] id: GO:0009914 name: hormone transport namespace: biological_process def: "The directed movement of hormones into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:tb] subset: goslim_pir is_a: GO:0006810 ! transport is_a: GO:0010817 ! regulation of hormone levels [Term] id: GO:0009915 name: phloem loading namespace: biological_process def: "The process of loading sucrose into the sieve tube or companion cell of the phloem for long distance transport from source to sink." [GOC:sm] is_a: GO:0008643 ! carbohydrate transport [Term] id: GO:0009916 name: alternative oxidase activity namespace: molecular_function def: "Catalysis of the oxidation of ubiquinol by diverting electrons from the standard electron transfer chain, transferring them from ubiquinol to oxygen and generating water as the product." [ISBN:0943088399] is_a: GO:0016682 ! oxidoreductase activity, acting on diphenols and related substances as donors, oxygen as acceptor [Term] id: GO:0009917 name: sterol 5-alpha reductase activity namespace: molecular_function def: "Catalysis of the removal of a C-5 double bond in the B ring of a sterol." [ISBN:0943088399] is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009918 name: sterol delta7 reductase activity namespace: molecular_function def: "Catalysis of the reaction: 5-dehydroepisterol = 24-methylenecholesterol." [ISBN:0943088399] synonym: "sterol delta-7 reductase activity" EXACT [] xref: MetaCyc:RXN-707 is_a: GO:0016627 ! oxidoreductase activity, acting on the CH-CH group of donors [Term] id: GO:0009919 name: cytokinesis (sensu Viridiplantae) namespace: biological_process def: "OBSOLETE. The division of a cell into two daughter cells with cell walls." [GOC:tb] comment: This term was made obsolete because its meaning was changed significantly. is_obsolete: true consider: GO:0000911 [Term] id: GO:0009920 name: cell plate formation involved in plant-type cell wall biogenesis namespace: biological_process def: "The cell cycle process whereby the cell plate is formed at the equator of the spindle in the dividing cells during early telophase. An example of this is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0879015322] synonym: "cell plate formation involved in cellulose and pectin-containing cell wall biogenesis" EXACT [] is_a: GO:0000919 ! cell plate assembly is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0007067 ! mitosis relationship: part_of GO:0009832 ! plant-type cell wall biogenesis [Term] id: GO:0009921 name: auxin efflux carrier complex namespace: cellular_component def: "The protein complex associated with the plasma membrane of certain plant cells (e.g. root cortex, epidermal cells) that functions to transport auxin out of the cell." [PMID:9843496] is_a: GO:0043234 ! protein complex is_a: GO:0044459 ! plasma membrane part [Term] id: GO:0009922 name: fatty acid elongase activity namespace: molecular_function def: "Catalysis of the reaction: fatty acid (C-16 or longer) + 2-C = fatty acid (C-16 or longer + 2-C)." [GOC:tb] xref: MetaCyc:ICOSANOYL-COA-SYNTHASE-RXN is_a: GO:0004312 ! fatty acid synthase activity [Term] id: GO:0009923 name: fatty acid elongase complex namespace: cellular_component def: "A tetrameric complex of four different subunits which catalyzes the elongation of fatty acids chains 2 carbon units at a time in the synthesis of very long chain fatty acids." [GOC:tb] is_a: GO:0043234 ! protein complex relationship: part_of GO:0005789 ! endoplasmic reticulum membrane [Term] id: GO:0009924 name: octadecanal decarbonylase activity namespace: molecular_function def: "Catalysis of the reaction: octadecanal = heptadecane + CO." [EC:4.1.99.5, GOC:tb] synonym: "octadecanal alkane-lyase activity" EXACT [] xref: EC:4.1.99.5 xref: MetaCyc:OCTADECANAL-DECARBONYLASE-RXN is_a: GO:0071771 ! aldehyde decarbonylase activity [Term] id: GO:0009925 name: basal plasma membrane namespace: cellular_component def: "The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis." [GOC:go_curators] is_a: GO:0044459 ! plasma membrane part relationship: part_of GO:0016323 ! basolateral plasma membrane relationship: part_of GO:0045178 ! basal part of cell [Term] id: GO:0009926 name: auxin polar transport namespace: biological_process def: "The unidirectional movement of auxin in the stem from tip to base along the vector of gravity or basipetally." [GOC:sm] is_a: GO:0060918 ! auxin transport [Term] id: GO:0009927 name: histidine phosphotransfer kinase activity namespace: molecular_function def: "Serves as a phospho-His intermediate enabling the transfer of phospho group between a hybrid kinase and a response regulator." [PMID:11842140] subset: gosubset_prok is_a: GO:0004871 ! signal transducer activity is_a: GO:0016301 ! kinase activity [Term] id: GO:0009930 name: longitudinal side of cell surface namespace: cellular_component def: "The side of the cell parallel to the zygotic axis." [GOC:mtg_sensu, GOC:sm] is_a: GO:0044464 ! cell part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0009931 name: calcium-dependent protein serine/threonine kinase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + a protein serine/threonine = ADP + protein serine/threonine phosphate, dependent on the presence of calcium ions." [GOC:mah] is_a: GO:0004674 ! protein serine/threonine kinase activity is_a: GO:0010857 ! calcium-dependent protein kinase activity [Term] id: GO:0009932 name: cell tip growth namespace: biological_process def: "Growth that occurs specifically at the tip of a cell." [GOC:jid] is_a: GO:0009826 ! unidimensional cell growth [Term] id: GO:0009933 name: meristem structural organization namespace: biological_process def: "Organization of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm, ISBN:0198547684] synonym: "meristem organisation" BROAD [] synonym: "meristem organization" BROAD [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0009934 name: regulation of meristem structural organization namespace: biological_process def: "Any process that modulates the frequency, rate or extent of meristem organization." [GOC:jid] synonym: "regulation of meristem organisation" EXACT [] synonym: "regulation of meristem organization" BROAD [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0048509 ! regulation of meristem development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009933 ! meristem structural organization relationship: regulates GO:0009933 ! meristem structural organization [Term] id: GO:0009935 name: nutrient import namespace: biological_process def: "OBSOLETE. The directed movement of nutrients into a cell or organelle." [GOC:sm] comment: This term was made obsolete because "nutrient" is not defined, and does not have a consistent meaning. subset: gosubset_prok synonym: "nutrient uptake" EXACT [] is_obsolete: true consider: GO:0006810 [Term] id: GO:0009936 name: expansin namespace: molecular_function def: "OBSOLETE. A group of proteins located within the cell walls of plants, both dicots and grasses, that play an essential role in loosening cell walls during cell growth. They are hydrophobic, non glycosylated proteins of about 30kDa." [ISBN:0198547684] comment: This term was made obsolete because it represents a gene product. is_obsolete: true replaced_by: GO:0009505 replaced_by: GO:0016049 [Term] id: GO:0009937 name: regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gibberellic acid mediated signaling." [GOC:go_curators] synonym: "regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009938 name: negative regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "down regulation of gibberellic acid mediated signaling" EXACT [] synonym: "down-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "downregulation of gibberellic acid mediated signaling" EXACT [] synonym: "inhibition of gibberellic acid mediated signaling" NARROW [] synonym: "negative regulation of gibberellic acid mediated signalling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0035467 ! negative regulation of signaling pathway is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: negatively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009939 name: positive regulation of gibberellic acid mediated signaling pathway namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of gibberellic acid mediated signaling activity." [GOC:sm] synonym: "activation of gibberellic acid mediated signaling" NARROW [] synonym: "positive regulation of gibberellic acid mediated signalling" EXACT [] synonym: "stimulation of gibberellic acid mediated signaling" NARROW [] synonym: "up regulation of gibberellic acid mediated signaling" EXACT [] synonym: "up-regulation of gibberellic acid mediated signaling" EXACT [] synonym: "upregulation of gibberellic acid mediated signaling" EXACT [] is_a: GO:0009937 ! regulation of gibberellic acid mediated signaling pathway is_a: GO:0035468 ! positive regulation of signaling pathway is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway relationship: positively_regulates GO:0009740 ! gibberellic acid mediated signaling pathway [Term] id: GO:0009940 name: amino-terminal vacuolar sorting propeptide binding namespace: molecular_function def: "Interacting selectively and non-covalently with an amino terminal propeptide, which functions as a sorting signal to sort away the soluble vacuolar protein from Golgi to lytic vacuole via clathrin coated vesicles." [GOC:sm, PMID:10871276] is_a: GO:0010209 ! vacuolar sorting signal binding [Term] id: GO:0009941 name: chloroplast envelope namespace: cellular_component def: "The double lipid bilayer enclosing the chloroplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space." [GOC:tb] is_a: GO:0009526 ! plastid envelope is_a: GO:0044434 ! chloroplast part [Term] id: GO:0009942 name: longitudinal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the longitudinal axis. In plants, this is the axis that runs from the shoot to the root." [GOC:tb] synonym: "apical-basal pattern specification" EXACT [] synonym: "longitudinal axis determination" RELATED [GOC:dph] is_a: GO:0000578 ! embryonic axis specification is_a: GO:0003006 ! reproductive developmental process relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0009943 name: adaxial/abaxial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the adaxial / abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] synonym: "adaxial/abaxial determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009955 ! adaxial/abaxial pattern formation [Term] id: GO:0009944 name: polarity specification of adaxial/abaxial axis namespace: biological_process def: "The process resulting in the establishment of polarity along the adaxial/abaxial axis. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009943 ! adaxial/abaxial axis specification [Term] id: GO:0009945 name: radial axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of an axis that initiates at a point and radiates outward from the point." [GOC:dph, GOC:go_curators, GOC:isa_complete] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009956 ! radial pattern formation [Term] id: GO:0009946 name: proximal/distal axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "proximal/distal axis determination" RELATED [GOC:dph] synonym: "proximodistal axis specification" EXACT [] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009954 ! proximal/distal pattern formation [Term] id: GO:0009947 name: centrolateral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the centrolateral axis. In plants, this axis is duplicated and runs from the midrib to the margin of the leaf." [GOC:tb, ISBN:0865427429] synonym: "centrolateral axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification [Term] id: GO:0009948 name: anterior/posterior axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the anterior/posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "anterior/posterior axis determination" RELATED [GOC:dph] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009952 ! anterior/posterior pattern formation [Term] id: GO:0009949 name: polarity specification of anterior/posterior axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the anterior/posterior axis." [GOC:go_curators] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009948 ! anterior/posterior axis specification [Term] id: GO:0009950 name: dorsal/ventral axis specification namespace: biological_process def: "The establishment, maintenance and elaboration of the dorsal/ventral axis. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:tb] synonym: "dorsal-ventral axis specification" EXACT [GOC:mah] synonym: "dorsal/ventral axis determination" RELATED [GOC:dph] synonym: "dorsoventral axis specification" EXACT [GOC:mah] is_a: GO:0009798 ! axis specification relationship: part_of GO:0009953 ! dorsal/ventral pattern formation [Term] id: GO:0009951 name: polarity specification of dorsal/ventral axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the dorsal/ventral axis." [GOC:go_curators] synonym: "polarity specification of dorsal-ventral axis" EXACT [GOC:mah] synonym: "polarity specification of dorsoventral axis" EXACT [GOC:mah] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009950 ! dorsal/ventral axis specification [Term] id: GO:0009952 name: anterior/posterior pattern formation namespace: biological_process def: "The regionalization process by which specific areas of cell differentiation are determined along the anterior-posterior axis. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "anterior/posterior pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009953 name: dorsal/ventral pattern formation namespace: biological_process def: "The regionalization process by which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism." [GOC:dph, GOC:go_curators, GOC:isa_complete, GOC:tb] synonym: "dorsal-ventral pattern formation" EXACT [GOC:mah] synonym: "dorsal/ventral pattern specification" NARROW [] synonym: "dorsoventral pattern formation" EXACT [GOC:mah] is_a: GO:0003002 ! regionalization [Term] id: GO:0009954 name: proximal/distal pattern formation namespace: biological_process def: "The regionalization process by which specific areas of cell differentiation are determined along a proximal/distal axis. The proximal/distal axis is defined by a line that runs from main body (proximal end) of an organism outward (distal end)." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "proximal/distal pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009955 name: adaxial/abaxial pattern formation namespace: biological_process def: "The regionalization process by which differences in cell differentiation along the adaxial/abaxial are generated. Adaxial refers to being situated toward an axis of an anatomical structure. Abaxial refers to being situated away from an axis of an anatomical structure." [GOC:dph, GOC:isa_complete, GOC:tb] synonym: "adaxial/abaxial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009956 name: radial pattern formation namespace: biological_process def: "The regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur." [GOC:dph, GOC:go_curators, GOC:isa_complete] synonym: "radial pattern specification" NARROW [] is_a: GO:0003002 ! regionalization [Term] id: GO:0009957 name: epidermal cell fate specification namespace: biological_process alt_id: GO:0043356 def: "The process by which a cell becomes capable of differentiating autonomously into an epidermal cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mtg_sensu, GOC:sm] synonym: "hypodermal cell fate specification" RELATED [GOC:kmv, GOC:rk] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0009913 ! epidermal cell differentiation [Term] id: GO:0009958 name: positive gravitropism namespace: biological_process def: "The orientation of plant parts towards gravity." [GOC:sm] synonym: "root gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009959 name: negative gravitropism namespace: biological_process def: "The orientation of plant parts away from gravity." [GOC:sm] synonym: "shoot gravitropism" NARROW [] is_a: GO:0009630 ! gravitropism [Term] id: GO:0009960 name: endosperm development namespace: biological_process def: "The process whose specific outcome is the progression of the endosperm over time, from its formation to the mature structure. The endosperm is formed during fertilization and provides nutrients to the developing embryo." [GOC:sm] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009888 ! tissue development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0009961 name: response to 1-aminocyclopropane-1-carboxylic acid namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 1-aminocyclopropane-1-carboxylic acid stimulus." [GOC:jl] is_a: GO:0009725 ! response to hormone stimulus [Term] id: GO:0009962 name: regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "regulation of flavonoid anabolism" EXACT [] synonym: "regulation of flavonoid biosynthesis" EXACT [] synonym: "regulation of flavonoid formation" EXACT [] synonym: "regulation of flavonoid synthesis" EXACT [] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0080090 ! regulation of primary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009813 ! flavonoid biosynthetic process relationship: regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009963 name: positive regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "activation of flavonoid biosynthetic process" NARROW [] synonym: "positive regulation of flavonoid anabolism" EXACT [] synonym: "positive regulation of flavonoid biosynthesis" EXACT [] synonym: "positive regulation of flavonoid formation" EXACT [] synonym: "positive regulation of flavonoid synthesis" EXACT [] synonym: "stimulation of flavonoid biosynthetic process" NARROW [] synonym: "up regulation of flavonoid biosynthetic process" EXACT [] synonym: "up-regulation of flavonoid biosynthetic process" EXACT [] synonym: "upregulation of flavonoid biosynthetic process" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009813 ! flavonoid biosynthetic process relationship: positively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009964 name: negative regulation of flavonoid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of flavonoids." [GOC:tb] subset: gosubset_prok synonym: "down regulation of flavonoid biosynthetic process" EXACT [] synonym: "down-regulation of flavonoid biosynthetic process" EXACT [] synonym: "downregulation of flavonoid biosynthetic process" EXACT [] synonym: "inhibition of flavonoid biosynthetic process" NARROW [] synonym: "negative regulation of flavonoid anabolism" EXACT [] synonym: "negative regulation of flavonoid biosynthesis" EXACT [] synonym: "negative regulation of flavonoid formation" EXACT [] synonym: "negative regulation of flavonoid synthesis" EXACT [] is_a: GO:0009962 ! regulation of flavonoid biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009813 ! flavonoid biosynthetic process relationship: negatively_regulates GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0009965 name: leaf morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the leaf are generated and organized. Morphogenesis pertains to the creation of form." [GOC:go_curators] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0048366 ! leaf development [Term] id: GO:0009966 name: regulation of signal transduction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok is_a: GO:0010646 ! regulation of cell communication is_a: GO:0023051 ! regulation of signaling process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007165 ! signal transduction relationship: regulates GO:0007165 ! signal transduction [Term] id: GO:0009967 name: positive regulation of signal transduction namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "activation of signal transduction" NARROW [] synonym: "stimulation of signal transduction" NARROW [] synonym: "up regulation of signal transduction" EXACT [] synonym: "up-regulation of signal transduction" EXACT [] synonym: "upregulation of signal transduction" EXACT [] xref: Reactome:110518 "Activated DTOR also phosphorylates D4EBP" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0023056 ! positive regulation of signaling process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0007165 ! signal transduction relationship: positively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009968 name: negative regulation of signal transduction namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of signal transduction." [GOC:sm] subset: gosubset_prok synonym: "down regulation of signal transduction" EXACT [] synonym: "down-regulation of signal transduction" EXACT [] synonym: "downregulation of signal transduction" EXACT [] synonym: "inhibition of signal transduction" NARROW [] xref: Reactome:110485 "DTSC1 AND DTSC2 form a complex" is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0023057 ! negative regulation of signaling process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0007165 ! signal transduction relationship: negatively_regulates GO:0007165 ! signal transduction [Term] id: GO:0009969 name: xyloglucan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of xyloglucan, the cross-linking glycan composed of 1->4-beta-D glucan backbone substituted at regular intervals with beta-D-xylosyl-1->6 residues, which is present in the primary cell wall of most higher plants." [GOC:sm] subset: gosubset_prok synonym: "xyloglucan anabolism" EXACT [] synonym: "xyloglucan biosynthesis" EXACT [] synonym: "xyloglucan formation" EXACT [] synonym: "xyloglucan synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process [Term] id: GO:0009970 name: cellular response to sulfate starvation namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of sulfate." [GOC:sm] synonym: "cellular response to sulphate starvation" EXACT [] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0009971 name: anastral spindle assembly involved in male meiosis namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the anastral spindle in male meiotic cells." [GOC:tb, PMID:11973272] is_a: GO:0007053 ! spindle assembly involved in male meiosis is_a: GO:0055048 ! anastral spindle assembly [Term] id: GO:0009972 name: cytidine deamination namespace: biological_process def: "The removal of amino group in the presence of water." [GOC:sm] subset: gosubset_prok is_a: GO:0006216 ! cytidine catabolic process [Term] id: GO:0009973 name: adenylyl-sulfate reductase activity namespace: molecular_function def: "Catalysis of the reaction: AMP + SO3(2-) (sulfite) + acceptor = adenylyl sulfate + reduced acceptor." [EC:1.8.99.2, PMID:5421934] subset: gosubset_prok synonym: "adenosine 5'-phosphosulfate reductase" EXACT [EC:1.8.99.2] synonym: "adenosine phosphosulfate reductase activity" EXACT [EC:1.8.99.2] synonym: "adenylyl-sulphate reductase activity" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:(acceptor) oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "AMP, sulfite:acceptor oxidoreductase (adenosine-5'-phosphosulfate-forming)" EXACT [EC:1.8.99.2] synonym: "APS reductase activity" EXACT [EC:1.8.99.2] synonym: "APS-reductase" EXACT [EC:1.8.99.2] xref: EC:1.8.99.2 xref: MetaCyc:ADENYLYLSULFATE-REDUCTASE-RXN is_a: GO:0016667 ! oxidoreductase activity, acting on sulfur group of donors [Term] id: GO:0009974 name: epsilon hydroxylase activity namespace: molecular_function def: "Catalysis of the hydroxylation of zeinoxanthin to lutein. Adds hydroxy group to the epsilon ring of the alpha-carotene." [PMID:8837513] is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0009975 name: cyclase activity namespace: molecular_function def: "Catalysis of a ring closure reaction." [ISBN:0198547684] subset: goslim_pir subset: gosubset_prok is_a: GO:0003824 ! catalytic activity [Term] id: GO:0009976 name: tocopherol cyclase activity namespace: molecular_function def: "Catalysis of the reaction: alkene group + alcohol group on same molecule = cyclic ether. Substrates are 2-methyl-6-phytyl-1,4- hydroquinone (forms delta-tocopherol) and 2,3-dimethyl-5-phytyl-1,4-hydroquinone (forms gamma-tocopherol)." [PMID:12213958] is_a: GO:0009975 ! cyclase activity [Term] id: GO:0009977 name: proton motive force dependent protein transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of proteins from one side of the membrane to the other. Transportation is dependent on pH gradient across the membrane." [PMID:11526245] synonym: "delta-pH-dependent protein transporter activity" EXACT [] synonym: "pH-dependent protein transporter activity" EXACT [] is_a: GO:0015291 ! secondary active transmembrane transporter activity is_a: GO:0015450 ! P-P-bond-hydrolysis-driven protein transmembrane transporter activity [Term] id: GO:0009978 name: allene oxide synthase activity namespace: molecular_function def: "Catalysis of the reaction: 13(S)-hydroperoxylinolenate = 12,13(S)-epoxylinolenate + H2O." [EC:4.2.1.92, MetaCyc:RXN1F-19, PMID:9778849] synonym: "(9Z,11E,14Z)-(13S)-hydroperoxyoctadeca-9,11,14-trienoate 12,13-hydro-lyase [(9Z)-(13S)-12,13-epoxyoctadeca-9,11-dienoate-forming]" RELATED [EC:4.2.1.92] synonym: "HPI" RELATED [EC:4.2.1.92] synonym: "linoleate hydroperoxide isomerase" RELATED [EC:4.2.1.92] synonym: "linoleic acid hydroperoxide isomerase" RELATED [EC:4.2.1.92] xref: MetaCyc:RXN1F-19 is_a: GO:0016836 ! hydro-lyase activity [Term] id: GO:0009979 name: 16:0 monogalactosyldiacylglycerol desaturase activity namespace: molecular_function def: "Catalysis of the introduction of an omega-3 double bond into an unsaturated 16-carbon fatty acid in a monogalactosyldiacylglycerol molecule." [GOC:mah, MetaCyc:RXN-1728, MetaCyc:RXN-8304, MetaCyc:RXN-8307] is_a: GO:0042389 ! omega-3 fatty acid desaturase activity [Term] id: GO:0009980 name: glutamate carboxypeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of C-terminal glutamate residues from a wide range of N-acylating moieties, including peptidyl, aminoacyl, benzoyl, benzyloxycarbonyl, folyl and pteroyl groups." [EC:3.4.17.11, MetaCyc:3.4.17.11-RXN] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. subset: gosubset_prok synonym: "carboxypeptidase G activity" BROAD [EC:3.4.17.11] synonym: "carboxypeptidase G1 activity" RELATED [EC:3.4.17.11] synonym: "carboxypeptidase G2 activity" RELATED [EC:3.4.17.11] synonym: "glutamyl carboxypeptidase activity" EXACT [EC:3.4.17.11] synonym: "N-pteroyl-L-glutamate hydrolase activity" EXACT [EC:3.4.17.11] xref: EC:3.4.17.11 xref: MetaCyc:3.4.17.11-RXN is_obsolete: true replaced_by: GO:0004180 [Term] id: GO:0009982 name: pseudouridine synthase activity namespace: molecular_function alt_id: GO:0016439 def: "Catalysis of the reaction: RNA uridine = RNA pseudouridine. Conversion of uridine in an RNA molecule to pseudouridine by rotation of the C1'-N-1 glycosidic bond of uridine in RNA to a C1'-C5." [EC:5.4.99.12, GOC:mah] comment: Note that this term should not be confused with 'pseudouridylate synthase activity ; GO:0004730', which refers to the formation of free pseudouridine from uracil and ribose-5-phosphate. subset: gosubset_prok synonym: "transfer ribonucleate pseudouridine synthetase activity" NARROW [EC:5.4.99.12] synonym: "transfer RNA pseudouridine synthetase activity" NARROW [EC:5.4.99.12] synonym: "tRNA pseudouridylate synthase I activity" NARROW [EC:5.4.99.12] synonym: "tRNA-pseudouridine synthase activity" NARROW [] synonym: "tRNA-pseudouridine synthase I activity" NARROW [] synonym: "tRNA-uridine isomerase activity" NARROW [EC:5.4.99.12] synonym: "tRNA-uridine uracilmutase activity" NARROW [EC:5.4.99.12] xref: EC:5.4.99.12 xref: MetaCyc:TRNA-PSEUDOURIDINE-SYNTHASE-I-RXN is_a: GO:0016866 ! intramolecular transferase activity [Term] id: GO:0009983 name: tyrosine aminopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the release of N-terminal tyrosine from a peptide." [GOC:sm, ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology"] comment: This term was made obsolete because it represents a gene product, and the substrate specificity it refers to is not cleanly defined. is_obsolete: true replaced_by: GO:0004177 [Term] id: GO:0009984 name: adenylate forming enzyme activity namespace: molecular_function def: "OBSOLETE. Catalysis of the reaction: substrate + ATP = substrate-AMP + diphosphate." [PMID:12084835] comment: This term was made obsolete because it does not refer to a specific reaction but rather to a process which results in the formation of AMP. is_obsolete: true consider: GO:0046033 [Term] id: GO:0009985 name: dihydroflavonol(thiole) lyase activity namespace: molecular_function is_a: GO:0016829 ! lyase activity [Term] id: GO:0009986 name: cell surface namespace: cellular_component alt_id: GO:0009928 alt_id: GO:0009929 def: "The external part of the cell wall and/or plasma membrane." [GOC:jl, GOC:mtg_sensu, GOC:sm] comment: Note that this term is intended to annotate gene products that are attached (integrated or loosely bound) to the plasma membrane or cell wall. subset: goslim_goa subset: goslim_pir subset: gosubset_prok synonym: "cell associated" EXACT [] synonym: "cell bound" EXACT [] is_a: GO:0044464 ! cell part [Term] id: GO:0009987 name: cellular process namespace: biological_process alt_id: GO:0008151 alt_id: GO:0050875 def: "Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level." [GOC:go_curators, GOC:isa_complete] subset: goslim_goa subset: goslim_pir subset: goslim_plant subset: gosubset_prok synonym: "cell growth and/or maintenance" NARROW [] synonym: "cell physiology" EXACT [] synonym: "cellular physiological process" EXACT [] is_a: GO:0008150 ! biological_process [Term] id: GO:0009988 name: cell-cell recognition namespace: biological_process def: "Cell recognition between cells, usually involving the formation of specialized cell junctions." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009989 name: cell-matrix recognition namespace: biological_process def: "Cell recognition that involves the interaction of the cell with the extracellular matrix." [ISBN:0824072820] is_a: GO:0008037 ! cell recognition [Term] id: GO:0009990 name: contact guidance namespace: biological_process def: "Cell recognition involving the deposition of specific pathways in the extracellular matrix that guide migrating cells." [ISBN:0824072820] is_a: GO:0009989 ! cell-matrix recognition [Term] id: GO:0009991 name: response to extracellular stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus." [GOC:go_curators] subset: goslim_plant subset: gosubset_prok is_a: GO:0009605 ! response to external stimulus [Term] id: GO:0009992 name: cellular water homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of water within a cell." [GOC:dph, GOC:tb] synonym: "cellular osmoregulation" RELATED [GOC:dph, GOC:tb] is_a: GO:0006884 ! cell volume homeostasis is_a: GO:0030104 ! water homeostasis is_a: GO:0055082 ! cellular chemical homeostasis [Term] id: GO:0009994 name: oocyte differentiation namespace: biological_process def: "The process whereby a relatively unspecialized immature germ cell acquires the specialized features of a mature female gamete." [GOC:go_curators, GOC:mtg_sensu] synonym: "oocyte cell differentiation" EXACT [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048477 ! oogenesis [Term] id: GO:0009995 name: soluble molecule recognition namespace: biological_process def: "The recognition of soluble molecules in the environment." [GOC:go_curators] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0009996 name: negative regulation of cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from adopting a specific cell fate." [GOC:go_curators] synonym: "down regulation of cell fate specification" EXACT [] synonym: "down-regulation of cell fate specification" EXACT [] synonym: "downregulation of cell fate specification" EXACT [] synonym: "inhibition of cell fate specification" NARROW [] synonym: "suppression of cell fate" EXACT [] is_a: GO:0010454 ! negative regulation of cell fate commitment is_a: GO:0042659 ! regulation of cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0001708 ! cell fate specification relationship: negatively_regulates GO:0001708 ! cell fate specification [Term] id: GO:0009997 name: negative regulation of cardioblast cell fate specification namespace: biological_process alt_id: GO:0042687 def: "Any process that restricts, stops or prevents a cell from specifying into a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "down regulation of cardioblast cell fate specification" EXACT [] synonym: "down-regulation of cardioblast cell fate specification" EXACT [] synonym: "downregulation of cardioblast cell fate specification" EXACT [] synonym: "inhibition of cardioblast cell fate specification" NARROW [] synonym: "suppression of cardioblast cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042686 ! regulation of cardioblast cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042685 ! cardioblast cell fate specification relationship: negatively_regulates GO:0042685 ! cardioblast cell fate specification [Term] id: GO:0009998 name: negative regulation of retinal cone cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into a retinal cone cell." [GOC:go_curators] synonym: "down regulation of retinal cone cell fate specification" EXACT [] synonym: "down-regulation of retinal cone cell fate specification" EXACT [] synonym: "downregulation of retinal cone cell fate specification" EXACT [] synonym: "inhibition of retinal cone cell fate specification" NARROW [] synonym: "negative regulation of retina cone cell fate specification" EXACT [] synonym: "suppression of retina cone cell fate" EXACT [] synonym: "suppression of retinal cone cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042673 ! regulation of retinal cone cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042672 ! retinal cone cell fate specification relationship: negatively_regulates GO:0042672 ! retinal cone cell fate specification [Term] id: GO:0009999 name: negative regulation of auditory receptor cell fate specification namespace: biological_process def: "Any process that restricts, stops or prevents a cell from specifying into an auditory hair cell." [GOC:go_curators] synonym: "down regulation of auditory receptor cell fate specification" EXACT [] synonym: "down-regulation of auditory receptor cell fate specification" EXACT [] synonym: "downregulation of auditory receptor cell fate specification" EXACT [] synonym: "inhibition of auditory receptor cell fate specification" NARROW [] synonym: "negative regulation of auditory hair cell fate specification" EXACT [] synonym: "suppression of auditory receptor cell fate" EXACT [] synonym: "suppression of hair cell fate" EXACT [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0042669 ! regulation of auditory receptor cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0042667 ! auditory receptor cell fate specification relationship: negatively_regulates GO:0042667 ! auditory receptor cell fate specification [Term] id: GO:0010001 name: glial cell differentiation namespace: biological_process alt_id: GO:0007404 alt_id: GO:0043360 def: "The process whereby a relatively unspecialized cell acquires the specialized features of a glial cell." [GOC:go_curators, GOC:mtg_sensu] synonym: "glia cell differentiation" EXACT [] synonym: "neuroglia differentiation" EXACT [] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0042063 ! gliogenesis [Term] id: GO:0010002 name: cardioblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized mesodermal cell acquires the specialized structural and/or functional features of a cardioblast. A cardioblast is a cardiac precursor cell. It is a cell that has been committed to a cardiac fate, but will undergo more cell division rather than terminally differentiating." [GOC:go_curators] synonym: "cardiac precursor cell differentiation" EXACT [GOC:mtg_heart] synonym: "cardioblast cell differentiation" EXACT [] synonym: "cardiomyocyte generation" RELATED [] is_a: GO:0035051 ! cardiac cell differentiation [Term] id: GO:0010004 name: gastrulation involving germ band extension namespace: biological_process def: "A complex and coordinated series of cellular movements, including germ band extension, that occurs at the end of cleavage during embryonic development. An example of this process is found in Drosophila melanogaster." [GOC:go_curators, GOC:mtg_sensu] is_a: GO:0001703 ! gastrulation with mouth forming first [Term] id: GO:0010005 name: cortical microtubule, transverse to long axis namespace: cellular_component def: "Arrays of microtubules underlying and connected to the plasma membrane, in the cortical cytosol, oriented mainly with their axes transverse to the long axis of the cell (and root in plants). In plants it influences the direction of cellulose microfibril deposition." [ISBN:0943088399] is_a: GO:0055028 ! cortical microtubule [Term] id: GO:0010006 name: Toc complex namespace: cellular_component def: "Protein translocon complex at the chloroplast outer membrane." [PMID:10646606] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010007 name: magnesium chelatase complex namespace: cellular_component def: "A heterotrimeric enzyme complex composed of three subunits, all of which are required for enzyme activity, which catalyzes the chelation of Mg by proto IX in an ATP-dependent manner." [PMID:11842180] is_a: GO:0043234 ! protein complex is_a: GO:0044434 ! chloroplast part [Term] id: GO:0010008 name: endosome membrane namespace: cellular_component def: "The lipid bilayer surrounding an endosome." [GOC:mah] is_a: GO:0031090 ! organelle membrane is_a: GO:0044440 ! endosomal part [Term] id: GO:0010009 name: external side of endosome membrane namespace: cellular_component def: "The external (cytoplasmic face) of an endosome membrane." [GOC:lr] is_a: GO:0044425 ! membrane part is_a: GO:0044440 ! endosomal part relationship: part_of GO:0010008 ! endosome membrane [Term] id: GO:0010011 name: auxin binding namespace: molecular_function def: "Interacting selectively and non-covalently with auxin, plant hormones that regulate aspects of plant growth." [GOC:sm] synonym: "auxin receptor" NARROW [] is_a: GO:0042562 ! hormone binding [Term] id: GO:0010012 name: steroid 22-alpha hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: 5-alpha-campestanaol + O2 = 6-deoxocathasterone + H2O." [GOC:tb] is_a: GO:0008395 ! steroid hydroxylase activity [Term] id: GO:0010013 name: N-1-naphthylphthalamic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with N-1-naphthylphthalamic acid, an auxin transport inhibitor." [GOC:sm] is_a: GO:0008144 ! drug binding [Term] id: GO:0010014 name: meristem initiation namespace: biological_process def: "Initiation of a region of tissue in a plant that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation, thereby effecting growth and development of a plant by giving rise to more meristem or specialized tissue." [GOC:sm] is_a: GO:0032502 ! developmental process relationship: part_of GO:0009933 ! meristem structural organization [Term] id: GO:0010015 name: root morphogenesis namespace: biological_process def: "The process by which the anatomical structures of roots are generated and organized. Morphogenesis pertains to the creation of form. The root is the usually underground part of a seed plant body that originates from the hypocotyl, functions as an organ of absorption, aeration, and food storage or as a means of anchorage and support." [GOC:sm, ISBN:0877797099] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048364 ! root development [Term] id: GO:0010016 name: shoot morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the shoot are generated and organized. Morphogenesis pertains to the creation of form. The shoot is the part of a seed plant body that is usually above ground." [GOC:sm, ISBN:0877797099] is_a: GO:0009653 ! anatomical structure morphogenesis relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0010017 name: red or far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light. Red light is electromagnetic radiation of wavelength of 580-700nm. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "phytochrome signaling pathway" BROAD [] synonym: "red or far red light signalling pathway" EXACT [] synonym: "red or far-red light signaling pathway" EXACT [GOC:tb] synonym: "red/far red light signaling pathway" EXACT [] is_a: GO:0023033 ! signaling pathway is_a: GO:0071489 ! cellular response to red or far red light [Term] id: GO:0010018 name: far-red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of far red light by a photoreceptor molecule. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:lr, GOC:mtg_far_red, GOC:sm] synonym: "far red light signalling pathway" EXACT [] synonym: "far red signaling pathway" EXACT [GOC:tb] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071490 ! cellular response to far red light [Term] id: GO:0010019 name: chloroplast-nucleus signaling pathway namespace: biological_process def: "The process by which a molecular signal is transduced between the chloroplast and nucleus, such that expression of nuclear encoding photosynthetic proteins is coupled with chloroplast biogenesis." [PMID:8972595] synonym: "chloroplast-nucleus signalling pathway" EXACT [] is_a: GO:0023034 ! intracellular signaling pathway [Term] id: GO:0010020 name: chloroplast fission namespace: biological_process def: "The division of a chloroplast within a cell to form two or more separate chloroplast compartments. This division occurs independently of mitosis." [GOC:lr] synonym: "chloroplast division" EXACT [] is_a: GO:0009658 ! chloroplast organization is_a: GO:0043572 ! plastid fission [Term] id: GO:0010021 name: amylopectin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of amylopectin, the (1,4) linked alpha glucose units with alpha-(1,6) linkages." [ISBN:0943088399] subset: gosubset_prok synonym: "amylopectin anabolism" EXACT [] synonym: "amylopectin biosynthesis" EXACT [] synonym: "amylopectin formation" EXACT [] synonym: "amylopectin synthesis" EXACT [] is_a: GO:0009250 ! glucan biosynthetic process relationship: part_of GO:0019252 ! starch biosynthetic process [Term] id: GO:0010022 name: meristem determinacy namespace: biological_process def: "The process by which a meristem becomes determinate (i.e. ceases to produce lateral organs and may or may not terminally differentiate)." [GOC:lr] is_a: GO:0032502 ! developmental process relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010023 name: proanthocyanidin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of proanthocyanidin." [GOC:lm] subset: gosubset_prok synonym: "proanthocyanidin anabolism" EXACT [] synonym: "proanthocyanidin biosynthesis" EXACT [] synonym: "proanthocyanidin formation" EXACT [] synonym: "proanthocyanidin synthesis" EXACT [] xref: MetaCyc:PWY-641 is_a: GO:0009813 ! flavonoid biosynthetic process [Term] id: GO:0010024 name: phytochromobilin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytochromobilin, which involves the oxidative cleavage of heme by a heme oxygenase(HO) to form biliverdin IX alpha." [PMID:11402195] subset: gosubset_prok synonym: "phytochromobilin anabolism" EXACT [] synonym: "phytochromobilin biosynthesis" EXACT [] synonym: "phytochromobilin formation" EXACT [] synonym: "phytochromobilin synthesis" EXACT [] is_a: GO:0033014 ! tetrapyrrole biosynthetic process is_a: GO:0051188 ! cofactor biosynthetic process is_a: GO:0051202 ! phytochromobilin metabolic process [Term] id: GO:0010025 name: wax biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of wax, which includes C16 and C18 fatty acids." [ISBN:0943088399] subset: gosubset_prok synonym: "wax anabolism" EXACT [] synonym: "wax biosynthesis" EXACT [] synonym: "wax formation" EXACT [] synonym: "wax synthesis" EXACT [] xref: MetaCyc:PWY-282 is_a: GO:0006633 ! fatty acid biosynthetic process is_a: GO:0010166 ! wax metabolic process [Term] id: GO:0010026 name: trichome differentiation namespace: biological_process alt_id: GO:0048271 def: "The process whereby a relatively unspecialized epidermal cell acquires the specialized features of a trichome cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, PMID:9367433] synonym: "trichome cell differentiation" EXACT [] is_a: GO:0035315 ! hair cell differentiation relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010027 name: thylakoid membrane organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the thylakoid membrane." [GOC:dph, GOC:jl, GOC:mah, GOC:tb] comment: See also the cellular component term 'thylakoid membrane ; GO:0042651'. synonym: "thylakoid membrane organisation" EXACT [GOC:curators] synonym: "thylakoid membrane organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009668 ! plastid membrane organization [Term] id: GO:0010028 name: xanthophyll cycle namespace: biological_process def: "A cyclic series of interconversions involving three xanthophylls, violoxanthin, antheraxanthin, and zeaxanthin. The xanthophyll cycle is involved in regulating energy dissipation in light harvesting complex II." [ISBN:0122146743] subset: gosubset_prok xref: MetaCyc:PWY-1141 xref: Wikipedia:Xanthophyll#Xanthophyll_cycle is_a: GO:0016122 ! xanthophyll metabolic process [Term] id: GO:0010029 name: regulation of seed germination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of seed germination." [GOC:sm] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009845 ! seed germination relationship: regulates GO:0009845 ! seed germination [Term] id: GO:0010030 name: positive regulation of seed germination namespace: biological_process def: "Any process that activates or increase the rate of seed germination." [GOC:sm] synonym: "activation of seed germination" NARROW [] synonym: "stimulation of seed germination" NARROW [] synonym: "up regulation of seed germination" EXACT [] synonym: "up-regulation of seed germination" EXACT [] synonym: "upregulation of seed germination" EXACT [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048582 ! positive regulation of post-embryonic development is_a: GO:0051240 ! positive regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009845 ! seed germination relationship: positively_regulates GO:0009845 ! seed germination [Term] id: GO:0010031 name: circumnutation namespace: biological_process def: "The organismal movement by which the tip of a plant organ follows a spiral pattern as a consequence of growth." [GOC:mtg_MIT_16mar07, ISBN:0192801023] is_a: GO:0050879 ! multicellular organismal movement [Term] id: GO:0010032 name: meiotic chromosome condensation namespace: biological_process def: "Compaction of chromatin structure prior to meiosis in eukaryotic cells." [PMID:10072401] synonym: "chromosome condensation involved in meiotic cell cycle" EXACT [GOC:dph, GOC:tb] is_a: GO:0030261 ! chromosome condensation relationship: part_of GO:0051321 ! meiotic cell cycle [Term] id: GO:0010033 name: response to organic substance namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010034 name: response to acetate namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an acetate stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0010033 ! response to organic substance [Term] id: GO:0010035 name: response to inorganic substance namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an inorganic substance stimulus." [GOC:sm] subset: gosubset_prok is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010036 name: response to boron namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a boron stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010037 name: response to carbon dioxide namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carbon dioxide (CO2) stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010038 name: response to metal ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus." [GOC:sm] subset: gosubset_prok synonym: "heavy metal sensitivity/resistance" RELATED [] synonym: "response to heavy metal" NARROW [] synonym: "response to metal" EXACT [] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010039 name: response to iron ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron ion stimulus." [GOC:sm] synonym: "response to iron" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010040 name: response to iron(II) ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(II) ion stimulus." [GOC:sm] synonym: "response to iron(II)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010041 name: response to iron(III) ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iron(III) ion stimulus." [GOC:sm] synonym: "response to iron(III)" EXACT [] is_a: GO:0010039 ! response to iron ion [Term] id: GO:0010042 name: response to manganese ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a manganese ion stimulus." [GOC:sm] synonym: "response to manganese" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010043 name: response to zinc ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus." [GOC:sm] synonym: "response to zinc" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010044 name: response to aluminum ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an aluminum ion stimulus." [GOC:sm] synonym: "response to aluminium ion" EXACT [] synonym: "response to aluminum" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010045 name: response to nickel ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel ion stimulus." [GOC:sm] synonym: "response to nickel" EXACT [] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010046 name: response to mycotoxin namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin are a toxic chemical substance produced by fungi." [GOC:sm] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010047 name: fruit dehiscence namespace: biological_process def: "The process leading to the spontaneous opening of the fruit permitting the escape of seeds." [GOC:tb, ISBN:0471245208] is_a: GO:0009900 ! dehiscence [Term] id: GO:0010048 name: vernalization response namespace: biological_process def: "The process of thermal induction in plants in which flowering is promoted by exposure to low temperatures." [GOC:tair_curators, ISBN:0521591392] is_a: GO:0009409 ! response to cold [Term] id: GO:0010049 name: acquisition of reproductive competence namespace: biological_process def: "The process by which a plant acquires the ability to respond to a floral inductive signal." [GOC:tair_curators] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010050 name: vegetative phase change namespace: biological_process def: "Any process involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tb] is_a: GO:0009791 ! post-embryonic development [Term] id: GO:0010051 name: xylem and phloem pattern formation namespace: biological_process def: "The regionalization process that gives rise to the patterning of the conducting tissues. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "vascular tissue pattern formation" EXACT [] is_a: GO:0003002 ! regionalization [Term] id: GO:0010052 name: guard cell differentiation namespace: biological_process def: "The process whereby a guard mother cell acquires the specialized features of a guard cell." [GOC:expert_db, GOC:tb] synonym: "stomatal cell differentiation" RELATED [] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010053 name: root epidermal cell differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell in the root epidermis acquires the specialized features of a trichoblast or atrichoblast." [GOC:tb] is_a: GO:0009913 ! epidermal cell differentiation relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010054 name: trichoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of a trichoblast, a root epidermal cell that will give rise to a root hair." [GOC:tb] synonym: "trichoblast cell differentiation" EXACT [] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010055 name: atrichoblast differentiation namespace: biological_process def: "The process whereby a relatively unspecialized cell acquires the specialized features of an atrichoblast, a root epidermal cell that will not give rise to a root hair." [GOC:tb] is_a: GO:0010053 ! root epidermal cell differentiation [Term] id: GO:0010056 name: atrichoblast fate specification namespace: biological_process def: "The process involved in the specification of an atrichoblast." [GOC:tb] is_a: GO:0009957 ! epidermal cell fate specification relationship: part_of GO:0010055 ! atrichoblast differentiation [Term] id: GO:0010057 name: trichoblast fate specification namespace: biological_process def: "The process involved in the specification of a trichoblast." [GOC:tb] is_a: GO:0001708 ! cell fate specification relationship: part_of GO:0010054 ! trichoblast differentiation [Term] id: GO:0010058 name: regulation of atrichoblast fate specification namespace: biological_process def: "Any process that modulates atrichoblast fate specification." [GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045604 ! regulation of epidermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010056 ! atrichoblast fate specification relationship: regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010059 name: positive regulation of atrichoblast fate specification namespace: biological_process def: "Any process that induces or promotes atrichoblast fate specification." [GOC:tb] synonym: "activation of atrichoblast fate" NARROW [] synonym: "stimulation of atrichoblast fate" NARROW [] synonym: "up regulation of atrichoblast fate" EXACT [] synonym: "up-regulation of atrichoblast fate" EXACT [] synonym: "upregulation of atrichoblast fate" EXACT [] is_a: GO:0010058 ! regulation of atrichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010056 ! atrichoblast fate specification relationship: positively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010060 name: negative regulation of atrichoblast fate specification namespace: biological_process def: "Any process that suppresses atrichoblast fate specification." [GOC:tb] synonym: "down regulation of atrichoblast fate" EXACT [] synonym: "down-regulation of atrichoblast fate" EXACT [] synonym: "downregulation of atrichoblast fate" EXACT [] synonym: "inhibition of atrichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010058 ! regulation of atrichoblast fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010056 ! atrichoblast fate specification relationship: negatively_regulates GO:0010056 ! atrichoblast fate specification [Term] id: GO:0010061 name: regulation of trichoblast fate specification namespace: biological_process def: "Any process that modulates trichoblast fate specification." [GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0042659 ! regulation of cell fate specification is_a: GO:0045604 ! regulation of epidermal cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010057 ! trichoblast fate specification relationship: regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010062 name: negative regulation of trichoblast fate specification namespace: biological_process def: "Any process that suppresses trichoblast fate specification." [GOC:tb] synonym: "down regulation of trichoblast fate" EXACT [] synonym: "down-regulation of trichoblast fate" EXACT [] synonym: "downregulation of trichoblast fate" EXACT [] synonym: "inhibition of trichoblast fate" NARROW [] is_a: GO:0009996 ! negative regulation of cell fate specification is_a: GO:0010061 ! regulation of trichoblast fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010057 ! trichoblast fate specification relationship: negatively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010063 name: positive regulation of trichoblast fate specification namespace: biological_process def: "Any process that induces or promotes trichoblast fate specification." [GOC:tb] synonym: "activation of trichoblast fate" NARROW [] synonym: "stimulation of trichoblast fate" NARROW [] synonym: "up regulation of trichoblast fate" EXACT [] synonym: "up-regulation of trichoblast fate" EXACT [] synonym: "upregulation of trichoblast fate" EXACT [] is_a: GO:0010061 ! regulation of trichoblast fate specification is_a: GO:0042660 ! positive regulation of cell fate specification intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010057 ! trichoblast fate specification relationship: positively_regulates GO:0010057 ! trichoblast fate specification [Term] id: GO:0010064 name: embryonic shoot morphogenesis namespace: biological_process def: "The process by which the anatomical structures of embryonic shoot are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb] is_a: GO:0010016 ! shoot morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010065 name: primary meristem tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the primary meristem over time, from formation to the mature structure, as it occurs during plant embryogenesis. The primary meristem tissue is the protoderm, ground meristem and procambium." [GOC:tb, ISBN:0471245208] synonym: "primary meristem histogenesis" EXACT [] is_a: GO:0048508 ! embryonic meristem development [Term] id: GO:0010066 name: ground meristem histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the ground tissues." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010067 name: procambium histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the primary vascular tissue." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010068 name: protoderm histogenesis namespace: biological_process def: "The formation of the primary meristem or meristematic tissue that gives rise to the epidermis." [GOC:tb, ISBN:0471245208] is_a: GO:0010065 ! primary meristem tissue development [Term] id: GO:0010069 name: zygote asymmetric cytokinesis in the embryo sac namespace: biological_process def: "The division of the zygote in a plane perpendicular to the long axis of the embryo sac to produce a larger basal cell near the micropyle and a small terminal cell close to what was the central cell and is now the developing endosperm. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb, ISBN:0865427429] is_a: GO:0010070 ! zygote asymmetric cell division is_a: GO:0033205 ! cell cycle cytokinesis is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010070 name: zygote asymmetric cell division namespace: biological_process def: "The division of the zygote into two daughter cells that will adopt developmentally distinct potentials." [GOC:tb] synonym: "zygote asymmetric cytokinesis" RELATED [] is_a: GO:0008356 ! asymmetric cell division [Term] id: GO:0010071 name: root meristem specification namespace: biological_process def: "The specification of a meristem which will give rise to a primary or lateral root." [GOC:ascb_2009, GOC:dph, GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010014 ! meristem initiation relationship: part_of GO:0010015 ! root morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010072 name: primary shoot apical meristem specification namespace: biological_process def: "The specification of the meristem which will give rise to all post-embryonic above-ground structures of the plant as well as the non-root below-ground structures, such as rhizomes and tubers." [GOC:ascb_2009, GOC:dph, GOC:tair_curators, GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010014 ! meristem initiation relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0048508 ! embryonic meristem development [Term] id: GO:0010073 name: meristem maintenance namespace: biological_process def: "Any process involved in maintaining the identity, size and shape of a meristem." [GOC:tb] is_a: GO:0032502 ! developmental process relationship: part_of GO:0048507 ! meristem development [Term] id: GO:0010074 name: maintenance of meristem identity namespace: biological_process alt_id: GO:0032503 def: "The process by which an organism retains a population of meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:tb] synonym: "maintenance of meristem cell identity" EXACT [] synonym: "meristem cell maintenance" EXACT [] is_a: GO:0019827 ! stem cell maintenance relationship: part_of GO:0010073 ! meristem maintenance [Term] id: GO:0010075 name: regulation of meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a meristem." [GOC:tb] synonym: "regulation of meristem size" EXACT [GOC:tb] is_a: GO:0048509 ! regulation of meristem development is_a: GO:0048638 ! regulation of developmental growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0035266 ! meristem growth relationship: part_of GO:0010073 ! meristem maintenance relationship: regulates GO:0035266 ! meristem growth [Term] id: GO:0010076 name: maintenance of floral meristem identity namespace: biological_process def: "The process by which an organism retains a population of floral meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010077 name: maintenance of inflorescence meristem identity namespace: biological_process def: "The process by which an organism retains a population of inflorescence meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010078 name: maintenance of root meristem identity namespace: biological_process def: "The process by which an organism retains a population of root meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity relationship: part_of GO:0010015 ! root morphogenesis [Term] id: GO:0010079 name: maintenance of vegetative meristem identity namespace: biological_process def: "The process by which an organism retains a population of vegetative meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010080 name: regulation of floral meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a floral meristem." [GOC:tb] synonym: "regulation of floral meristem size" EXACT [] is_a: GO:0009909 ! regulation of flower development is_a: GO:0010075 ! regulation of meristem growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010451 ! floral meristem growth relationship: regulates GO:0010451 ! floral meristem growth [Term] id: GO:0010081 name: regulation of inflorescence meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of an inflorescence meristem." [GOC:tb] synonym: "regulation of inflorescence meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010450 ! inflorescence meristem growth relationship: regulates GO:0010450 ! inflorescence meristem growth [Term] id: GO:0010082 name: regulation of root meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a root meristem." [GOC:tb] synonym: "regulation of root meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010449 ! root meristem growth relationship: part_of GO:0010015 ! root morphogenesis relationship: regulates GO:0010449 ! root meristem growth [Term] id: GO:0010083 name: regulation of vegetative meristem growth namespace: biological_process def: "Any process involved in maintaining the size and shape of a vegetative meristem." [GOC:tb] synonym: "regulation of vegetative meristem size" EXACT [GOC:tb] is_a: GO:0010075 ! regulation of meristem growth is_a: GO:0048831 ! regulation of shoot development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010448 ! vegetative meristem growth relationship: regulates GO:0010448 ! vegetative meristem growth [Term] id: GO:0010084 name: specification of organ axis polarity namespace: biological_process def: "The process by which the polarity of an organ axis is specified." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0010085 name: polarity specification of proximal/distal axis namespace: biological_process def: "Any process resulting in the establishment of polarity along the proximal/distal axis." [GOC:tb] is_a: GO:0065001 ! specification of axis polarity relationship: part_of GO:0009946 ! proximal/distal axis specification [Term] id: GO:0010086 name: embryonic root morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the embryonic root are generated and organized. Morphogenesis pertains to the creation of form." [GOC:tb] is_a: GO:0010015 ! root morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010087 name: phloem or xylem histogenesis namespace: biological_process def: "The process whose specific outcome is the progression of phloem and/or xylem over time, from formation to the mature structure. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tb] synonym: "phloem or xylem histogenesis" EXACT [GOC:tb] synonym: "vascular tissue development" BROAD [] synonym: "vascular tissue histogenesis" EXACT [] is_a: GO:0009888 ! tissue development [Term] id: GO:0010088 name: phloem development namespace: biological_process def: "The formation of the principal food-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "phloem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010089 name: xylem development namespace: biological_process def: "The formation of the principal water-conducting tissue of a vascular plant." [GOC:tb, ISBN:0471245208] synonym: "xylem histogenesis" EXACT [GOC:tb] is_a: GO:0010087 ! phloem or xylem histogenesis [Term] id: GO:0010090 name: trichome morphogenesis namespace: biological_process alt_id: GO:0048272 def: "The process by which the structures of a hair cell (trichome) cell are generated and organized. This process occurs while the initially relatively unspecialized epidermal cell is acquiring the specialized features of a hair cell. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] synonym: "trichome cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010026 ! trichome differentiation [Term] id: GO:0010091 name: trichome branching namespace: biological_process alt_id: GO:0048274 def: "Any process involved in the formation of branches in plant hair cells. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:tair_curators] is_a: GO:0000904 ! cell morphogenesis involved in differentiation relationship: part_of GO:0010090 ! trichome morphogenesis [Term] id: GO:0010092 name: specification of organ identity namespace: biological_process def: "The regionalization process by which the identity of an organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0003002 ! regionalization relationship: part_of GO:0048645 ! organ formation [Term] id: GO:0010093 name: specification of floral organ identity namespace: biological_process def: "The process by which the identity of a floral organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010092 ! specification of organ identity relationship: part_of GO:0048449 ! floral organ formation [Term] id: GO:0010094 name: specification of carpel identity namespace: biological_process def: "The process by which a floral organ primordium acquires the carpel identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048462 ! carpel formation [Term] id: GO:0010095 name: specification of petal identity namespace: biological_process def: "The process by which a floral organ primordium acquires petal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048451 ! petal formation [Term] id: GO:0010096 name: specification of sepal identity namespace: biological_process def: "The process by which a floral organ primordium acquires sepal identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048453 ! sepal formation [Term] id: GO:0010097 name: specification of stamen identity namespace: biological_process def: "The process by which a floral organ primordium acquires stamen or staminode identity. Identity is considered to be the aggregate of characteristics by which a structure is recognized." [GOC:tair_curators] is_a: GO:0010093 ! specification of floral organ identity relationship: part_of GO:0048455 ! stamen formation [Term] id: GO:0010098 name: suspensor development namespace: biological_process def: "The process whose specific outcome is the progression of the suspensor over time, from its formation to the mature structure. The suspensor is the extension at the base of the embryo that anchors the embryo in the embryo sac and pushes it into the endosperm." [GOC:tb, ISBN:0471245208] is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010099 name: regulation of photomorphogenesis namespace: biological_process def: "Any process that modulates the rate or extent of photomorphogenesis." [GOC:tb] is_a: GO:0048580 ! regulation of post-embryonic development is_a: GO:0048583 ! regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009640 ! photomorphogenesis relationship: regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010100 name: negative regulation of photomorphogenesis namespace: biological_process def: "Any process that stops, reduces or prevents photomorphogenesis." [GOC:tb] synonym: "down regulation of photomorphogenesis" EXACT [] synonym: "down-regulation of photomorphogenesis" EXACT [] synonym: "downregulation of photomorphogenesis" EXACT [] synonym: "inhibition of photomorphogenesis" NARROW [] is_a: GO:0010099 ! regulation of photomorphogenesis is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009640 ! photomorphogenesis relationship: negatively_regulates GO:0009640 ! photomorphogenesis [Term] id: GO:0010101 name: post-embryonic root morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the post-embryonic root are generated and organized. Morphogenesis pertains to the creation of form. The post-embryonic root is the root formed after the embryonic phase has been completed." [GOC:tb] is_a: GO:0009886 ! post-embryonic morphogenesis is_a: GO:0010015 ! root morphogenesis relationship: part_of GO:0048528 ! post-embryonic root development [Term] id: GO:0010102 name: lateral root morphogenesis namespace: biological_process def: "The process by which the anatomical structures of a lateral root are generated and organized. Morphogenesis pertains to the creation of form. A lateral root is one formed from pericycle cells located on the xylem radius of the root, as opposed to the initiation of the main root from the embryo proper." [GOC:tair_curators] is_a: GO:0010101 ! post-embryonic root morphogenesis relationship: part_of GO:0048527 ! lateral root development [Term] id: GO:0010103 name: stomatal complex morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the stomatal complex are generated and organized. Morphogenesis pertains to the creation of form. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [GOC:tair_curators] is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010104 name: regulation of ethylene mediated signaling pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of ethylene (ethene) mediated signaling." [GOC:tb] synonym: "regulation of ethene mediated signaling pathway" EXACT [] synonym: "regulation of ethene mediated signalling pathway" EXACT [] synonym: "regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0035466 ! regulation of signaling pathway is_a: GO:0048583 ! regulation of response to stimulus is_a: GO:0070297 ! regulation of two-component signal transduction system (phosphorelay) intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009873 ! ethylene mediated signaling pathway relationship: regulates GO:0009873 ! ethylene mediated signaling pathway [Term] id: GO:0010105 name: negative regulation of ethylene mediated signaling pathway namespace: biological_process def: "Any process that stops or prevents ethylene (ethene) mediated signaling." [GOC:tb] synonym: "down regulation of ethylene mediated signaling pathway" EXACT [] synonym: "down-regulation of ethylene mediated signaling pathway" EXACT [] synonym: "downregulation of ethylene mediated signaling pathway" EXACT [] synonym: "inhibition of ethylene mediated signaling pathway" NARROW [] synonym: "negative regulation of ethene mediated signaling pathway" EXACT [] synonym: "negative regulation of ethene mediated signalling pathway" EXACT [] synonym: "negative regulation of ethylene mediated signalling pathway" EXACT [] is_a: GO:0010104 ! regulation of ethylene mediated signaling pathway is_a: GO:0035467 ! negative regulation of signaling pathway is_a: GO:0048585 ! negative regulation of response to stimulus is_a: GO:0070298 ! negative regulation of two-component signal transduction system (phosphorelay) intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009873 ! ethylene mediated signaling pathway relationship: negatively_regulates GO:0009873 ! ethylene mediated signaling pathway [Term] id: GO:0010106 name: cellular response to iron ion starvation namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of iron ions." [GOC:mg] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010107 name: potassium ion import namespace: biological_process def: "The directed movement of potassium ions into a cell or organelle." [GOC:sm] synonym: "potassium import" EXACT [] synonym: "potassium ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006813 ! potassium ion transport [Term] id: GO:0010108 name: detection of glutamine namespace: biological_process def: "The series of events in which a glutamine stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "glutamine detection" EXACT [] synonym: "glutamine perception" RELATED [] synonym: "glutamine sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010109 name: regulation of photosynthesis namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis." [GOC:sm] subset: gosubset_prok is_a: GO:0031323 ! regulation of cellular metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015979 ! photosynthesis relationship: regulates GO:0015979 ! photosynthesis [Term] id: GO:0010110 name: regulation of photosynthesis, dark reaction namespace: biological_process def: "Any process that modulates the frequency, rate or extent of photosynthesis dark reaction." [GOC:sm] is_a: GO:0010109 ! regulation of photosynthesis is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019685 ! photosynthesis, dark reaction relationship: regulates GO:0019685 ! photosynthesis, dark reaction [Term] id: GO:0010111 name: glyoxysome organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the glyoxysome. A glyoxysome is a microbody that contains the enzymes of the glyoxylate pathway." [GOC:tb] synonym: "glyoxysome organisation" EXACT [GOC:curators] synonym: "glyoxysome organization and biogenesis" RELATED [GOC:mah] is_a: GO:0009657 ! plastid organization [Term] id: GO:0010112 name: regulation of systemic acquired resistance namespace: biological_process def: "Any process that modulates the frequency, rate or extent of systemic acquired resistance." [GOC:sm] is_a: GO:0002831 ! regulation of response to biotic stimulus is_a: GO:0043900 ! regulation of multi-organism process is_a: GO:0045088 ! regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009627 ! systemic acquired resistance relationship: regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010113 name: negative regulation of systemic acquired resistance namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of systemic acquired resistance." [GOC:sm] synonym: "down regulation of systemic acquired resistance" EXACT [] synonym: "down-regulation of systemic acquired resistance" EXACT [] synonym: "downregulation of systemic acquired resistance" EXACT [] synonym: "inhibition of systemic acquired resistance" NARROW [] is_a: GO:0002832 ! negative regulation of response to biotic stimulus is_a: GO:0010112 ! regulation of systemic acquired resistance is_a: GO:0043901 ! negative regulation of multi-organism process is_a: GO:0045824 ! negative regulation of innate immune response intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009627 ! systemic acquired resistance relationship: negatively_regulates GO:0009627 ! systemic acquired resistance [Term] id: GO:0010114 name: response to red light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "response to red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010115 name: regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] subset: gosubset_prok synonym: "regulation of abscisic acid anabolism" EXACT [] synonym: "regulation of abscisic acid biosynthesis" EXACT [] synonym: "regulation of abscisic acid formation" EXACT [] synonym: "regulation of abscisic acid synthesis" EXACT [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009688 ! abscisic acid biosynthetic process relationship: regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010116 name: positive regulation of abscisic acid biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid." [GOC:sm] subset: gosubset_prok synonym: "activation of abscisic acid biosynthetic process" NARROW [] synonym: "positive regulation of abscisic acid anabolism" EXACT [] synonym: "positive regulation of abscisic acid biosynthesis" EXACT [] synonym: "positive regulation of abscisic acid formation" EXACT [] synonym: "positive regulation of abscisic acid synthesis" EXACT [] synonym: "stimulation of abscisic acid biosynthetic process" NARROW [] synonym: "up regulation of abscisic acid biosynthetic process" EXACT [] synonym: "up-regulation of abscisic acid biosynthetic process" EXACT [] synonym: "upregulation of abscisic acid biosynthetic process" EXACT [] is_a: GO:0010115 ! regulation of abscisic acid biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009688 ! abscisic acid biosynthetic process relationship: positively_regulates GO:0009688 ! abscisic acid biosynthetic process [Term] id: GO:0010117 name: photoprotection namespace: biological_process def: "Protection mechanism used by plants under conditions of excess energy absorption as a consequence of the light reactions of photosynthesis." [GOC:mg] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010118 name: stomatal movement namespace: biological_process def: "The process of opening or closing of stomata, which is directly related to the stomatal conductance (measuring rate of passage of either water vapor or carbon dioxide (CO2) through stomata)." [GOC:sm] subset: goslim_pir is_a: GO:0009987 ! cellular process [Term] id: GO:0010119 name: regulation of stomatal movement namespace: biological_process def: "Any process that modulates the frequency, rate or extent of stomatal movement." [GOC:sm] is_a: GO:0050794 ! regulation of cellular process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010118 ! stomatal movement relationship: regulates GO:0010118 ! stomatal movement [Term] id: GO:0010120 name: camalexin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of camalexin, an indole phytoalexin." [GOC:pz] synonym: "camalexin anabolism" EXACT [] synonym: "camalexin biosynthesis" EXACT [] synonym: "camalexin formation" EXACT [] synonym: "camalexin synthesis" EXACT [] xref: MetaCyc:CAMALEXIN-SYN is_a: GO:0009700 ! indole phytoalexin biosynthetic process is_a: GO:0019438 ! aromatic compound biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process is_a: GO:0052317 ! camalexin metabolic process [Term] id: GO:0010121 name: arginine catabolic process to proline via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including proline, via ornithine." [GOC:pz] subset: gosubset_prok synonym: "arginine breakdown to proline via ornithine" EXACT [] synonym: "arginine degradation to proline via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0019493 ! arginine catabolic process to proline [Term] id: GO:0010122 name: arginine catabolic process to alanine via ornithine namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of arginine into other compounds, including alanine, via ornithine." [GOC:pz] subset: gosubset_prok synonym: "arginine breakdown to alanine via ornithine" EXACT [] synonym: "arginine degradation to alanine via ornithine" EXACT [] xref: MetaCyc:ARGORNPROST-PWY is_a: GO:0006527 ! arginine catabolic process [Term] id: GO:0010123 name: acetate catabolic process to butyrate, ethanol, acetone and butanol namespace: biological_process def: "The anaerobic chemical reactions and pathways resulting in the breakdown of acetate to form butyrate, ethanol, acetone and butanol." [GOC:pz] subset: gosubset_prok synonym: "acetate fermentation to butyrate, ethanol, acetone and butanol" EXACT [] xref: MetaCyc:CENTFERM-PWY is_a: GO:0019654 ! acetate fermentation [Term] id: GO:0010124 name: phenylacetate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of phenylacetate." [GOC:pz] subset: gosubset_prok synonym: "phenylacetate breakdown" EXACT [] synonym: "phenylacetate catabolism" EXACT [] synonym: "phenylacetate degradation" EXACT [] xref: MetaCyc:PWY0-321 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010125 name: mycothiol biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] subset: gosubset_prok synonym: "mycothiol anabolism" EXACT [] synonym: "mycothiol biosynthesis" EXACT [] synonym: "mycothiol formation" EXACT [] synonym: "mycothiol synthesis" EXACT [] xref: MetaCyc:PWY1G-0 is_a: GO:0010126 ! mycothiol metabolic process is_a: GO:0016138 ! glycoside biosynthetic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0010126 name: mycothiol metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mycothiol, which consists of N-acetyl-L-cysteine linked to a pseudodisaccharide, D-glucosamine and myo-inositol. Mycothiol is produced in actinomycetes like mycobacteria and serves similar functions to glutathione." [GOC:pz] subset: gosubset_prok synonym: "mycothiol metabolism" EXACT [] is_a: GO:0005984 ! disaccharide metabolic process is_a: GO:0006790 ! sulfur metabolic process is_a: GO:0016137 ! glycoside metabolic process is_a: GO:0051186 ! cofactor metabolic process [Term] id: GO:0010127 name: mycothiol-dependent detoxification namespace: biological_process def: "The chemical reactions using mycothiol to convert an alkylating agent to an S-conjugate of mycothiol. The latter is cleaved to release mercapturic acid which is excreted from the cell." [GOC:pz] synonym: "mycothiol-dependent detoxification of alkylating agent" NARROW [] xref: MetaCyc:PWY1G-1 xref: MetaCyc:PWY1G-170 is_a: GO:0009636 ! response to toxin [Term] id: GO:0010128 name: benzoate catabolic process via CoA ligation namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of benzoate, by its ligation to Coenzyme A to form benzoyl-CoA, which is then broken by an aerobic or anaerobic pathway." [GOC:pz] subset: gosubset_prok synonym: "anaerobic benzoate breakdown" EXACT [] synonym: "anaerobic benzoate catabolic process" EXACT [] synonym: "anaerobic benzoate catabolism" EXACT [] synonym: "anaerobic benzoate degradation" EXACT [] xref: MetaCyc:PWY-283 is_a: GO:0018875 ! anaerobic benzoate metabolic process is_a: GO:0043639 ! benzoate catabolic process [Term] id: GO:0010129 name: anaerobic cyclohexane-1-carboxylate catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of cyclohexane-1-carboxylate, a alicyclic acid, in the absence of oxygen." [GOC:pz] subset: gosubset_prok synonym: "anaerobic cyclohexane-1-carboxylate breakdown" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate catabolism" EXACT [] synonym: "anaerobic cyclohexane-1-carboxylate degradation" EXACT [] xref: MetaCyc:PWY-301 is_a: GO:0019439 ! aromatic compound catabolic process is_a: GO:0042178 ! xenobiotic catabolic process [Term] id: GO:0010130 name: anaerobic ethylbenzene catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ethylbenzene, a benzene derivative with an ethyl group attached to the ring, which occurs in the absence of oxygen." [GOC:pz] subset: gosubset_prok synonym: "anaerobic ethylbenzene breakdown" EXACT [] synonym: "anaerobic ethylbenzene catabolism" EXACT [] synonym: "anaerobic ethylbenzene degradation" EXACT [] xref: MetaCyc:PWY-481 is_a: GO:0018913 ! anaerobic ethylbenzene metabolic process is_a: GO:0043451 ! alkene catabolic process [Term] id: GO:0010131 name: sucrose catabolic process, using invertase or sucrose synthase namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of sucrose by the enzymatic action of either invertase or sucrose synthase." [GOC:pz] subset: gosubset_prok synonym: "sucrose breakdown, using invertase or sucrose synthase" EXACT [] synonym: "sucrose catabolism, using invertase or sucrose synthase" EXACT [] synonym: "sucrose degradation, using invertase or sucrose synthase" EXACT [] xref: MetaCyc:PWY-3801 xref: MetaCyc:PWY-621 is_a: GO:0005987 ! sucrose catabolic process [Term] id: GO:0010132 name: dhurrin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of dhurrin, a cyanogenic glucoside which functions as a plant defense compound." [GOC:pz] subset: gosubset_prok synonym: "dhurrin anabolism" EXACT [] synonym: "dhurrin biosynthesis" EXACT [] synonym: "dhurrin formation" EXACT [] synonym: "dhurrin synthesis" EXACT [] xref: MetaCyc:PWY-861 is_a: GO:0019756 ! cyanogenic glycoside biosynthetic process [Term] id: GO:0010133 name: proline catabolic process to glutamate namespace: biological_process alt_id: GO:0019494 def: "The chemical reactions and pathways resulting in the breakdown of proline into other compounds, including glutamate." [GOC:pz] subset: gosubset_prok synonym: "proline breakdown to glutamate" EXACT [] synonym: "proline degradation to glutamate" EXACT [] synonym: "proline oxidation" RELATED [] xref: MetaCyc:PROUT-PWY xref: MetaCyc:PWY-4561 is_a: GO:0006536 ! glutamate metabolic process is_a: GO:0006562 ! proline catabolic process [Term] id: GO:0010134 name: sulfate assimilation via adenylyl sulfate reduction namespace: biological_process def: "The pathway by which inorganic sulfate is activated, reduced and incorporated into sulfated compounds, where the activated sulfate, adenylyl-sulfate, is reduced to sulfite by the activity of adenylyl-sulfate reductase." [EC:1.8.99.2] subset: gosubset_prok synonym: "sulphate assimilation via adenylyl sulphate reduction" EXACT [] xref: MetaCyc:SULFMETII-PWY is_a: GO:0000103 ! sulfate assimilation is_a: GO:0019419 ! sulfate reduction [Term] id: GO:0010135 name: ureide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving ureide, allantoin and allantoate, which are the organic forms of nitrogen in nitrogen fixing and transporting plants." [GOC:pz] subset: gosubset_prok synonym: "ureide metabolism" EXACT [] is_a: GO:0006807 ! nitrogen compound metabolic process [Term] id: GO:0010136 name: ureide catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of ureide, which is the organic form of nitrogen in nitrogen fixing and transporting plants with the release of ammonium." [GOC:pz] subset: gosubset_prok synonym: "ureide breakdown" EXACT [] synonym: "ureide catabolism" EXACT [] synonym: "ureide degradation" EXACT [] xref: MetaCyc:URDEGR-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044270 ! cellular nitrogen compound catabolic process [Term] id: GO:0010137 name: ureide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of ureide, the organic form of nitrogen in nitrogen fixing and transporting plants, from IMP, which is synthesized de novo during nitrogen fixation by roots." [GOC:pz] subset: gosubset_prok synonym: "ureide anabolism" EXACT [] synonym: "ureide biosynthesis" EXACT [] synonym: "ureide formation" EXACT [] synonym: "ureide synthesis" EXACT [] xref: MetaCyc:URSIN-PWY is_a: GO:0010135 ! ureide metabolic process is_a: GO:0044271 ! cellular nitrogen compound biosynthetic process [Term] id: GO:0010138 name: pyrimidine ribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine ribonucleosides from pyrimidine nucleotide breakdown are converted back to pyrimidine ribonucleotides. The salvage pathway is important where there is no de novo pyrimidine nucleotide biosynthesis." [GOC:pz] subset: gosubset_prok xref: MetaCyc:PWY0-163 is_a: GO:0009220 ! pyrimidine ribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010139 name: pyrimidine deoxyribonucleotide salvage namespace: biological_process def: "The pathway by which pyrimidine bases or pyrimidine deoxyribonucleotides from pyrimidine nucleotide breakdown are converted back to pyrimidine deoxyribonucleotides. The salvage pathway is important where there is no de novo pyrimidine deoxyribonucleotide biosynthesis." [GOC:pz] subset: gosubset_prok xref: MetaCyc:PWY0-181 is_a: GO:0009221 ! pyrimidine deoxyribonucleotide biosynthetic process is_a: GO:0032262 ! pyrimidine nucleotide salvage [Term] id: GO:0010140 name: adenine, hypoxanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which adenine, hypoxanthine and their nucleosides from purine nucleotides breakdown are converted back to purine nucleotides. The salvage pathway is important where there is no de-novo purine nucleotide biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. is_obsolete: true replaced_by: GO:0006168 replaced_by: GO:0006169 replaced_by: GO:0006190 replaced_by: GO:0043103 [Term] id: GO:0010141 name: guanine, xanthine and their nucleoside salvage namespace: biological_process def: "OBSOLETE. The pathway by which guanine, xanthine and their nucleoside from purine nucleotides breakdown are converted back to purine nucleotides. The pathway is important in cells where there is no de-novo purine nucleotides biosynthesis." [GOC:pz] comment: This term was made obsolete because it represents multiple processes that are represented elsewhere in the process ontology. is_obsolete: true replaced_by: GO:0006178 replaced_by: GO:0006179 replaced_by: GO:0006190 replaced_by: GO:0043103 [Term] id: GO:0010142 name: farnesyl diphosphate biosynthetic process, mevalonate pathway namespace: biological_process def: "The pathway that converts acetate, in the form of acetyl-CoA, to farnesyl diphosphate (FPP) through a series of mevalonate intermediates. Farnesyl diphosphate is an important substrate for other essential pathways, such as biosynthesis of sterols." [GOC:pz, MetaCyc:PWY-922] subset: gosubset_prok synonym: "Ac-MVA pathway" NARROW [PMID:14517367] synonym: "acetate-mevalonate pathway" NARROW [PMID:14517367] synonym: "farnesyl diphosphate anabolism, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate formation, mevalonate pathway" EXACT [] synonym: "farnesyl diphosphate synthesis, mevalonate pathway" EXACT [] synonym: "isoprenoid pathway" EXACT [] xref: MetaCyc:PWY-922 is_a: GO:0045337 ! farnesyl diphosphate biosynthetic process relationship: part_of GO:0016114 ! terpenoid biosynthetic process [Term] id: GO:0010143 name: cutin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of cutin, a waxy substance, which combined with cellulose forms a substance nearly impervious to water and constituting the cuticle in plants." [ISBN:0028623819] synonym: "cutin anabolism" EXACT [] synonym: "cutin biosynthesis" EXACT [] synonym: "cutin formation" EXACT [] synonym: "cutin synthesis" EXACT [] xref: MetaCyc:PWY-321 is_a: GO:0006633 ! fatty acid biosynthetic process [Term] id: GO:0010144 name: pyridoxal phosphate biosynthetic process from pyridoxamine namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, the active form of vitamin B6, from pyridoxamine." [GOC:pz] subset: gosubset_prok synonym: "pyridoxal phosphate anabolism from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate formation from pyridoxamine" EXACT [] synonym: "pyridoxal phosphate synthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthesis from pyridoxamine" EXACT [] synonym: "vitamin B6 biosynthetic process from pyridoxamine" EXACT [] is_a: GO:0042818 ! pyridoxamine metabolic process is_a: GO:0042823 ! pyridoxal phosphate biosynthetic process [Term] id: GO:0010145 name: fructan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving fructan, a polysaccharide consisting of fructose residues." [GOC:sm] subset: gosubset_prok synonym: "fructan metabolism" EXACT [] synonym: "levan metabolic process" EXACT [] is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010146 name: fructan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of fructan a polysaccharide consisting of fructose residues." [GOC:pz] subset: gosubset_prok synonym: "fructan anabolism" EXACT [] synonym: "fructan biosynthesis" EXACT [] synonym: "fructan formation" EXACT [] synonym: "fructan synthesis" EXACT [] synonym: "levan biosynthesis" EXACT [] synonym: "levan biosynthetic process" EXACT [] xref: MetaCyc:PWY-822 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010147 name: fructan catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of fructan, a polysaccharide consisting of fructose residues." [GOC:pz] subset: gosubset_prok synonym: "fructan breakdown" EXACT [] synonym: "fructan catabolism" EXACT [] synonym: "fructan degradation" EXACT [] synonym: "levan catabolic process" EXACT [] synonym: "levan catabolism" EXACT [] xref: MetaCyc:PWY-862 is_a: GO:0010145 ! fructan metabolic process is_a: GO:0044247 ! cellular polysaccharide catabolic process [Term] id: GO:0010148 name: transpiration namespace: biological_process def: "Release of water by the plant into the air as water vapor mainly through leaves." [GOC:sm, ISBN:0879015322] xref: Wikipedia:Transpiration is_a: GO:0006833 ! water transport [Term] id: GO:0010149 name: senescence namespace: biological_process def: "A preprogrammed process associated with the dismantling of an anatomical structure and an overall decline in metabolism. This may include the breakdown of organelles, membranes and other cellular components. An example of this process is found in Arabidopsis thaliana, when older leaves or floral organs are shed." [GOC:mtg_sensu, ISBN:0387987819] xref: Wikipedia:Senescence is_a: GO:0007568 ! aging [Term] id: GO:0010150 name: leaf senescence namespace: biological_process def: "The process that occurs in a leaf near the end of its active life that is associated with the dismantling of cell components and membranes, loss of functional chloroplasts, and an overall decline in metabolism." [ISBN:0387987819] is_a: GO:0010260 ! organ senescence [Term] id: GO:0010151 name: chloroplast elongation namespace: biological_process def: "Expansion of the chloroplast that usually precedes division." [GOC:lr] is_a: GO:0009658 ! chloroplast organization [Term] id: GO:0010152 name: pollen maturation namespace: biological_process def: "The final stages of microgametogenesis after the trinucleate stage has been reached resulting in viable pollen grains." [PMID:11595796] is_a: GO:0021700 ! developmental maturation relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010153 name: polar cell elongation namespace: biological_process def: "OBSOLETE. Cell expansion that results in an increase in cell size along the axis of an organ in a polarized fashion." [PMID:11978864] comment: This term was made obsolete because it did not represent a process discrete from its sibling terms. synonym: "polarity-dependent cell elongation" NARROW [] is_obsolete: true consider: GO:0042814 consider: GO:0042815 [Term] id: GO:0010154 name: fruit development namespace: biological_process def: "The process whose specific outcome is the progression of the fruit over time, from its formation to the mature structure. The fruit is a reproductive body of a seed plant." [GOC:sm] is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010155 name: regulation of proton transport namespace: biological_process def: "Any process that modulates the frequency, rate or extent of proton transport into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:sm] is_a: GO:0043269 ! regulation of ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015992 ! proton transport relationship: regulates GO:0015992 ! proton transport [Term] id: GO:0010156 name: sporocyte morphogenesis namespace: biological_process def: "OBSOLETE. Formation and development of sporocyte, the haploid spores of angiosperms which are initiated by the differentiation of a subset of floral cells into sporocytes, which then undergo meiotic divisions to form microspores and megaspores." [PMID:10465788] comment: This term was made obsolete because it was incorrectly defined. is_obsolete: true consider: GO:0048533 [Term] id: GO:0010157 name: response to chlorate namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chlorate stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010158 name: abaxial cell fate specification namespace: biological_process def: "Process by which a cell becomes capable of differentiating autonomously into an abaxial cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification [Term] id: GO:0010159 name: specification of organ position namespace: biological_process def: "The regionalization process by which information that determines the correct position at which organ primordia are formed is generated and perceived resulting in correct positioning of the new organ." [PMID:9611175] is_a: GO:0003002 ! regionalization relationship: part_of GO:0009887 ! organ morphogenesis [Term] id: GO:0010160 name: formation of organ boundary namespace: biological_process alt_id: GO:0048862 def: "The regionalization process that specifies organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues." [GOC:dph, GOC:isa_complete, PMID:9611175] synonym: "organ boundary specification" EXACT [] is_a: GO:0003002 ! regionalization is_a: GO:0048859 ! formation of anatomical boundary relationship: part_of GO:0048645 ! organ formation [Term] id: GO:0010161 name: red light signaling pathway namespace: biological_process def: "The series of molecular signals initiated upon sensing of red light by a photoreceptor molecule. Red light is electromagnetic radiation of wavelength of 580-700nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:sm] synonym: "red light signalling pathway" EXACT [] is_a: GO:0010017 ! red or far-red light signaling pathway is_a: GO:0071491 ! cellular response to red light [Term] id: GO:0010162 name: seed dormancy namespace: biological_process def: "The process by which a dormant state is induced, maintained and broken in a seed. Dormancy is characterized by a suspension of physiological activity that can be reactivated." [GOC:lr] xref: Wikipedia:Seed#Seed_dormancy_and_protection is_a: GO:0003006 ! reproductive developmental process is_a: GO:0022611 ! dormancy process is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0010431 ! seed maturation [Term] id: GO:0010163 name: high-affinity potassium ion import namespace: biological_process def: "The directed, energized, high affinity movement of potassium ions into a cell or organelle, driven by cation symport with hydrogen or sodium ions." [PMID:8893537] synonym: "high affinity potassium ion import" EXACT [] synonym: "high affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] synonym: "high-affinity potassium ion uptake" EXACT [GOC:dph, GOC:tb] is_a: GO:0006813 ! potassium ion transport is_a: GO:0034220 ! ion transmembrane transport [Term] id: GO:0010164 name: response to cesium ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cesium stimulus." [GOC:sm] synonym: "response to cesium" EXACT [GOC:mah] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010165 name: response to X-ray namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of X-ray radiation. An X-ray is a form of electromagnetic radiation with a wavelength in the range of 10 nanometers to 100 picometers (corresponding to frequencies in the range 30 PHz to 3 EHz)." [GOC:sm, Wikipedia:X-ray] synonym: "response to X-ray radiation stimulus" EXACT [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010166 name: wax metabolic process namespace: biological_process def: "The chemical reactions and pathways involving wax, a compound containing C16 and C18 fatty acids." [GOC:sm] subset: gosubset_prok synonym: "wax metabolism" EXACT [] is_a: GO:0006631 ! fatty acid metabolic process [Term] id: GO:0010167 name: response to nitrate namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrate stimulus." [GOC:sm] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010168 name: ER body namespace: cellular_component def: "A novel compartment found in plant cells that is derived from the ER. The structures have a characteristic shape and size (10 mm long and 0.5 mm wide) and are surrounded with ribosomes. They have been found in Arabidopsis thaliana and related Brassicaceae species." [PMID:11577182] synonym: "endoplasmic reticulum body" EXACT [] is_a: GO:0043231 ! intracellular membrane-bounded organelle [Term] id: GO:0010169 name: thioglucosidase complex namespace: cellular_component def: "A large (200-800 kDa) multiprotein complex formed by 70-kDa and 5-kDa myrosinases, myrosinase- binding proteins (MBPs), MBP-related proteins and myrosinase-associated proteins. The complex has been identified in Brassica napus seeds." [PMID:10682349] synonym: "myrosinase complex" EXACT [] is_a: GO:0043234 ! protein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0010170 name: glucose-1-phosphate adenylyltransferase complex namespace: cellular_component def: "Complex that catalyzes the synthesis of ADP-glucose and pyrophosphate from glucose-1-phosphate and ATP. In plants, the complex is a heterotetramer composed of two types of subunits (small and large). In bacteria, the enzyme complex is composed of four identical subunits." [GOC:tb, PMID:12748181] subset: gosubset_prok is_a: GO:0043234 ! protein complex is_a: GO:0044424 ! intracellular part [Term] id: GO:0010171 name: body morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems, ISBN:0140512888] is_a: GO:0009653 ! anatomical structure morphogenesis [Term] id: GO:0010172 name: embryonic body morphogenesis namespace: biological_process def: "The process by which the anatomical structures of the embryonic soma are generated and organized. Morphogenesis pertains to the creation of form." [GOC:ems] is_a: GO:0010171 ! body morphogenesis is_a: GO:0048598 ! embryonic morphogenesis [Term] id: GO:0010174 name: nucleoside transmembrane transporter activity, against a concentration gradient namespace: molecular_function def: "Catalysis of the transfer of a nucleoside, from one side of a membrane to the other, up a concentration gradient." [GOC:tb] synonym: "concentrative nucleoside transporter activity" EXACT [] is_a: GO:0005337 ! nucleoside transmembrane transporter activity is_a: GO:0015291 ! secondary active transmembrane transporter activity [Term] id: GO:0010175 name: sphingosine transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of amino alcohol sphingosine from one side of the membrane to the other." [GOC:tb] is_a: GO:0005275 ! amine transmembrane transporter activity is_a: GO:0015665 ! alcohol transmembrane transporter activity [Term] id: GO:0010176 name: homogentisate phytyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + phytyl diphosphate -> 2-methyl-6-phytylplastoquinol." [PMID:14512521] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010177 name: methylthioalkylmalate synthase activity namespace: molecular_function def: "Catalysis of the reaction: w-methylthio-2-oxoalkanoic acid + acetyl-CoA + H2O = 2-(w-methylthio)alkylmalate + CoA." [GOC:pz] is_a: GO:0046912 ! transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer [Term] id: GO:0010178 name: IAA-amino acid conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the cleavage of the amide bond between IAA (auxin) and the conjugated amino acid." [GOC:tb] is_a: GO:0016810 ! hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds [Term] id: GO:0010179 name: IAA-Ala conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-alanine -> indole-3-acetic acid + alanine." [GOC:tb] xref: MetaCyc:RXN-2981 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010180 name: thioglucosidase binding namespace: molecular_function def: "Interacting selectively and non-covalently with the enzyme thioglucosidase." [GOC:tb] synonym: "myrosinase binding" EXACT [] is_a: GO:0019899 ! enzyme binding [Term] id: GO:0010181 name: FMN binding namespace: molecular_function def: "Interacting selectively and non-covalently with FMN, flavin mononucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes." [GOC:tb] subset: gosubset_prok synonym: "flavin mononucleotide binding" EXACT [] is_a: GO:0000166 ! nucleotide binding is_a: GO:0050662 ! coenzyme binding [Term] id: GO:0010182 name: sugar mediated signaling pathway namespace: biological_process def: "The process by which a change in the level of a mono- or disaccharide such as glucose, fructose or sucrose triggers the expression of genes controlling metabolic and developmental processes." [PMID:9014361] synonym: "sugar mediated signalling" EXACT [] is_a: GO:0009756 ! carbohydrate mediated signaling [Term] id: GO:0010183 name: pollen tube guidance namespace: biological_process def: "The process by which the growth of pollen tube is directed towards the female gametophyte." [GOC:lr] is_a: GO:0050918 ! positive chemotaxis relationship: part_of GO:0048868 ! pollen tube development [Term] id: GO:0010184 name: cytokinin transport namespace: biological_process def: "The directed movement of cytokinins, a class of adenine-derived compounds that can function in plants as growth regulators, into, out of, within or between cells by means of some external agent such as a transporter or pore." [GOC:lr] is_a: GO:0006863 ! purine transport is_a: GO:0009914 ! hormone transport [Term] id: GO:0010185 name: regulation of cellular defense response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "regulation of cellular defence response" EXACT [] is_a: GO:0031347 ! regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006968 ! cellular defense response relationship: regulates GO:0006968 ! cellular defense response [Term] id: GO:0010186 name: positive regulation of cellular defense response namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of cellular defense response." [GOC:sm] synonym: "activation of cellular defense response" NARROW [] synonym: "positive regulation of cellular defence response" EXACT [] synonym: "stimulation of cellular defense response" NARROW [] synonym: "up regulation of cellular defense response" EXACT [] synonym: "up-regulation of cellular defense response" EXACT [] synonym: "upregulation of cellular defense response" EXACT [] is_a: GO:0010185 ! regulation of cellular defense response is_a: GO:0031349 ! positive regulation of defense response intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006968 ! cellular defense response relationship: positively_regulates GO:0006968 ! cellular defense response [Term] id: GO:0010187 name: negative regulation of seed germination namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of seed germination." [GOC:tb] synonym: "down regulation of seed germination" EXACT [] synonym: "down-regulation of seed germination" EXACT [] synonym: "downregulation of seed germination" EXACT [] synonym: "inhibition of seed germination" NARROW [] is_a: GO:0010029 ! regulation of seed germination is_a: GO:0048581 ! negative regulation of post-embryonic development is_a: GO:0051241 ! negative regulation of multicellular organismal process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009845 ! seed germination relationship: negatively_regulates GO:0009845 ! seed germination [Term] id: GO:0010188 name: response to microbial phytotoxin namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a microbial phytotoxin stimulus. A microbial phytotoxin is a chemical substance produced by microbes which is toxic to plants." [GOC:sm] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010189 name: vitamin E biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of vitamin E, tocopherol, which includes a series of eight structurally similar compounds. Alpha-tocopherol is the most active form in humans and is a powerful biological antioxidant." [GOC:mg] subset: gosubset_prok synonym: "alpha-tocopherol biosynthesis" NARROW [] synonym: "alpha-tocopherol biosynthetic process" NARROW [] synonym: "tocopherol biosynthesis" EXACT [] synonym: "tocopherol biosynthetic process" EXACT [] synonym: "vitamin E anabolism" EXACT [] synonym: "vitamin E biosynthesis" EXACT [] synonym: "vitamin E formation" EXACT [] synonym: "vitamin E synthesis" EXACT [] xref: MetaCyc:PWY-1422 is_a: GO:0042360 ! vitamin E metabolic process is_a: GO:0042362 ! fat-soluble vitamin biosynthetic process [Term] id: GO:0010190 name: cytochrome b6f complex assembly namespace: biological_process def: "Formation of cytochrome b6f complex, a complex that transfers electrons from reduced plastoquinone to oxidized plastocyanin and translocates protons from the stroma to the lumen, by the aggregation, arrangement and bonding together of its constituents." [GOC:tb] subset: gosubset_prok synonym: "cytochrome b6f complex biogenesis" EXACT [] is_a: GO:0017004 ! cytochrome complex assembly [Term] id: GO:0010191 name: mucilage metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mucilage, a gelatinous substance secreted by plants." [GOC:sm] subset: goslim_pir synonym: "mucilage metabolism" EXACT [] is_a: GO:0044237 ! cellular metabolic process [Term] id: GO:0010192 name: mucilage biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of mucilage, a gelatinous substance secreted by plants." [GOC:sm] synonym: "mucilage anabolism" EXACT [] synonym: "mucilage biosynthesis" EXACT [] synonym: "mucilage formation" EXACT [] synonym: "mucilage synthesis" EXACT [] is_a: GO:0010191 ! mucilage metabolic process is_a: GO:0044249 ! cellular biosynthetic process [Term] id: GO:0010193 name: response to ozone namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ozone stimulus." [GOC:sm] is_a: GO:0042221 ! response to chemical stimulus [Term] id: GO:0010194 name: microRNA metabolic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways involving microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it implies further processing of an end product rather than its production. is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010195 name: microRNA biosynthetic process namespace: biological_process def: "OBSOLETE. The chemical reactions and pathways resulting in the formation of microRNA, a large family of 21-22 nucleotide non-coding RNAs with presumed post-transcriptional regulatory activity." [GOC:sm] comment: This term was made obsolete because it represents a process that is not known to occur. synonym: "microRNA anabolism" EXACT [] synonym: "microRNA biosynthesis" EXACT [] synonym: "microRNA formation" EXACT [] synonym: "microRNA synthesis" EXACT [] synonym: "miRNA biosynthesis" EXACT [] synonym: "miRNA biosynthetic process" EXACT [] is_obsolete: true replaced_by: GO:0035196 [Term] id: GO:0010196 name: nonphotochemical quenching namespace: biological_process def: "The process to maintain the balance between dissipation and utilization of light energy to minimize generation of oxidizing molecules, thereby protecting the plant against photo-oxidative damage." [PMID:10667783] is_a: GO:0009416 ! response to light stimulus [Term] id: GO:0010197 name: polar nucleus fusion namespace: biological_process def: "The merging of the polar nuclei, the two nuclei contained within the same cell that are created from the mitotic division of the megaspore during angiosperm reproduction. Polar nuclear fusion takes place in the ovule, forming in the fusion nucleus and giving rise to the endosperm when fertilized." [GOC:mtg_plant, GOC:sm] is_a: GO:0000741 ! karyogamy relationship: part_of GO:0009559 ! embryo sac central cell differentiation [Term] id: GO:0010198 name: synergid death namespace: biological_process alt_id: GO:0048470 def: "Synergid cells undergo degeneration and death in response to penetration by the pollen tube. It is an active process that involves a dramatic decrease in cell volume, collapse of the vacuoles, and complete disintegration of the plasma membrane and most organelles." [GOC:isa_complete, GOC:sm, PMID:12215516] synonym: "synergid cell death" EXACT [] synonym: "synergid degeneration" EXACT [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0010623 ! developmental programmed cell death is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010199 name: organ boundary specification between lateral organs and the meristem namespace: biological_process def: "The process by which boundaries between lateral organs and the meristem is established and maintained." [PMID:12068116] synonym: "organ boundary specification" BROAD [] is_a: GO:0010160 ! formation of organ boundary [Term] id: GO:0010200 name: response to chitin namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chitin stimulus." [GOC:sm] is_a: GO:0009743 ! response to carbohydrate stimulus [Term] id: GO:0010201 name: response to continuous far red light stimulus by the high-irradiance response system namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a continuous far red light stimulus by the high-irradiance response system. Far red light is electromagnetic radiation of wavelength 700-800nm. The activity of the high-irradiance response system is characterized by stronger effects of continuous than pulsed light at equal total fluence." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010218 ! response to far red light [Term] id: GO:0010202 name: response to low fluence red light stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Low fluence red light is defined in this case as short pulses of red light followed by darkness, providing a light level of 0.001-0.1 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0009645 ! response to low light intensity stimulus is_a: GO:0010114 ! response to red light [Term] id: GO:0010203 name: response to very low fluence red light stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very low fluence red light stimulus. Red light is electromagnetic radiation of wavelength of 580-700nm. Very low fluence red light is defined in this case as short pulses of red light followed by darkness, providing light levels of less than 0.001 mmol/m2/sec." [GOC:mtg_far_red, GOC:sm] is_a: GO:0010114 ! response to red light is_a: GO:0055122 ! response to very low light intensity stimulus [Term] id: GO:0010204 name: defense response signaling pathway, resistance gene-independent namespace: biological_process def: "A series of molecular signals that is activated during defense response and does not depend upon R-genes." [GOC:mah, GOC:sm] synonym: "defence response signaling pathway, resistance gene-independent" EXACT [] synonym: "defence response signalling pathway, resistance gene-independent" EXACT [] is_a: GO:0002218 ! activation of innate immune response is_a: GO:0023033 ! signaling pathway [Term] id: GO:0010205 name: photoinhibition namespace: biological_process def: "The mechanism by which high light intensity inhibits photosynthesis through inactivation of the D1 protein of photosystem II." [GOC:mtg_electron_transport, PMID:12068126] synonym: "photosystem II inhibition" BROAD [] xref: Wikipedia:Photoinhibition is_a: GO:0009644 ! response to high light intensity is_a: GO:0043155 ! negative regulation of photosynthesis, light reaction relationship: negatively_regulates GO:0009767 ! photosynthetic electron transport chain [Term] id: GO:0010206 name: photosystem II repair namespace: biological_process def: "Proteolysis of the damaged D1 protein and re-assembly of a new D1 subunit in the Photosystem II following photoinhibition." [GOC:sm] is_a: GO:0030091 ! protein repair relationship: part_of GO:0009765 ! photosynthesis, light harvesting [Term] id: GO:0010207 name: photosystem II assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a photosystem II complex on thylakoid membrane. In plants, the photosystem II complex consists of over 20 polypeptides encoded by either nuclear or chloroplast genome." [GOC:pz] is_a: GO:0043623 ! cellular protein complex assembly relationship: part_of GO:0019684 ! photosynthesis, light reaction [Term] id: GO:0010208 name: pollen wall assembly namespace: biological_process def: "The formation of reticulate pollen wall pattern consisting of two layers, exine and intine." [PMID:11743117] synonym: "pollen wall formation" RELATED [GOC:dph, GOC:tb] is_a: GO:0010927 ! cellular component assembly involved in morphogenesis is_a: GO:0045229 ! external encapsulating structure organization relationship: part_of GO:0009555 ! pollen development [Term] id: GO:0010209 name: vacuolar sorting signal binding namespace: molecular_function def: "Interacting selectively and non-covalently with a vacuolar sorting signal, a specific peptide sequence that acts as a signal to localize the protein within the vacuole." [GOC:mah] is_a: GO:0005048 ! signal sequence binding [Term] id: GO:0010210 name: IAA-Phe conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-phenylalanine -> indole-3-acetic acid + phenylalanine." [GOC:syr] is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010211 name: IAA-Leu conjugate hydrolase activity namespace: molecular_function def: "Catalysis of the reaction: IAA-leucine -> indole-3-acetic acid + leucine." [GOC:syr] xref: MetaCyc:RXN-2982 is_a: GO:0010178 ! IAA-amino acid conjugate hydrolase activity [Term] id: GO:0010212 name: response to ionizing radiation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ionizing radiation stimulus. Ionizing radiation is radiation with sufficient energy to remove electrons from atoms and may arise from spontaneous decay of unstable isotopes, resulting in alpha and beta particles and gamma rays. Ionizing radiation also includes X-rays." [PMID:12509526] synonym: "response to ionising radiation" EXACT [] synonym: "response to ionizing radiation stimulus" EXACT [] is_a: GO:0009314 ! response to radiation [Term] id: GO:0010213 name: non-photoreactive DNA repair namespace: biological_process def: "A DNA repair process that is involved in repairing UV-induced DNA damage under non-photoreactivating conditions. The mechanism by which this repair process operates has not yet been completely elucidated." [GOC:syr] subset: gosubset_prok synonym: "light-independent DNA repair" EXACT [GOC:syr] is_a: GO:0006281 ! DNA repair [Term] id: GO:0010214 name: seed coat development namespace: biological_process def: "The process whose specific outcome is the progression of the seed coat over time, from its formation to the mature structure." [GOC:go_curators] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010215 name: cellulose microfibril organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a cellulose microfibril, any of the cellulose structures laid down in orthogonal layers in a plant cell wall." [GOC:mah, PMID:12468730] synonym: "cellulose microfibril organisation" EXACT [GOC:curators] is_a: GO:0030198 ! extracellular matrix organization relationship: part_of GO:0071668 ! plant-type cell wall assembly [Term] id: GO:0010216 name: maintenance of DNA methylation namespace: biological_process def: "Any process involved in maintaining the methylation state of a nucleotide sequence." [PMID:11898023] is_a: GO:0006259 ! DNA metabolic process relationship: part_of GO:0006306 ! DNA methylation [Term] id: GO:0010217 name: cellular aluminum ion homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of aluminum ions at the level of a cell." [GOC:lr, GOC:mah] synonym: "cellular aluminium ion homeostasis" EXACT [GOC:mah] is_a: GO:0006875 ! cellular metal ion homeostasis is_a: GO:0055079 ! aluminum ion homeostasis [Term] id: GO:0010218 name: response to far red light namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of far red light stimulus. Far red light is electromagnetic radiation of wavelength 700-800nm. An example of this response is seen at the beginning of many plant species developmental stages. These include germination, and the point when cotyledon expansion is triggered. In certain species these processes take place in response to absorption of red light by the pigment molecule phytochrome, but the signal can be reversed by exposure to far red light. During the initial phase the phytochrome molecule is only present in the red light absorbing form, but on absorption of red light it changes to a far red light absorbing form, triggering progress through development. An immediate short period of exposure to far red light entirely returns the pigment to its initial state and prevents triggering of the developmental process. A thirty minute break between red and subsequent far red light exposure renders the red light effect irreversible, and development then occurs regardless of whether far red light exposure subsequently occurs." [GOC:mtg_far_red, GOC:tb] synonym: "response to far red light stimulus" EXACT [] is_a: GO:0009639 ! response to red or far red light [Term] id: GO:0010219 name: regulation of vernalization response namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] is_a: GO:0080134 ! regulation of response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010048 ! vernalization response relationship: regulates GO:0010048 ! vernalization response [Term] id: GO:0010220 name: positive regulation of vernalization response namespace: biological_process def: "Any process that activates or induces the rate of the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "activation of vernalization response" NARROW [] synonym: "stimulation of vernalization response" NARROW [] synonym: "up regulation of vernalization response" EXACT [] synonym: "up-regulation of vernalization response" EXACT [] synonym: "upregulation of vernalization response" EXACT [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048584 ! positive regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0010048 ! vernalization response relationship: positively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010221 name: negative regulation of vernalization response namespace: biological_process def: "Any process that stops, prevents or reduces the vernalization response, by which induction of flowering is normally caused by extended exposure to cold temperatures." [GOC:sm] synonym: "down regulation of vernalization response" EXACT [] synonym: "down-regulation of vernalization response" EXACT [] synonym: "downregulation of vernalization response" EXACT [] synonym: "inhibition of vernalization response" NARROW [] is_a: GO:0010219 ! regulation of vernalization response is_a: GO:0048585 ! negative regulation of response to stimulus intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010048 ! vernalization response relationship: negatively_regulates GO:0010048 ! vernalization response [Term] id: GO:0010222 name: stem vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the stem of vascular plants." [GOC:tb] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010223 name: secondary shoot formation namespace: biological_process def: "The process that gives rise to secondary (or auxiliary or axillary) shoots in plants. This process pertains to the initial formation of a structure from unspecified parts. These secondary shoots originate from secondary meristems initiated in the axils of leaf primordia. Axillary meristems function like the shoot apical meristem of the primary shoot initating the development of lateral organs." [GOC:tb, PMID:12815068] synonym: "auxiliary shoot formation" EXACT [] synonym: "axillary shoot formation" EXACT [] is_a: GO:0010346 ! shoot formation [Term] id: GO:0010224 name: response to UV-B namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-B radiation stimulus. UV-B radiation (UV-B light) spans the wavelengths 290 to 320 nm." [GOC:tb] synonym: "response to medium wave ultraviolet light stimulus" EXACT [] synonym: "response to medium wave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-B light stimulus" EXACT [] synonym: "response to UV-B radiation stimulus" EXACT [] synonym: "response to UVB light stimulus" EXACT [] synonym: "response to UVB radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010225 name: response to UV-C namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a UV-C radiation stimulus. UV-C radiation (UV-C light) spans the wavelengths 100 to 290 nm." [GOC:tb] synonym: "response to germicidal ultraviolet light stimulus" EXACT [] synonym: "response to germicidal ultraviolet radiation stimulus" EXACT [] synonym: "response to shortwave ultraviolet light stimulus" EXACT [] synonym: "response to shortwave ultraviolet radiation stimulus" EXACT [] synonym: "response to UV-C light stimulus" EXACT [] synonym: "response to UV-C radiation stimulus" EXACT [] synonym: "response to UVC light stimulus" EXACT [] synonym: "response to UVC radiation stimulus" EXACT [] is_a: GO:0009411 ! response to UV [Term] id: GO:0010226 name: response to lithium ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus." [GOC:tb] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010227 name: floral organ abscission namespace: biological_process def: "The controlled shedding of floral organs." [PMID:12972671] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0009838 ! abscission relationship: part_of GO:0048437 ! floral organ development [Term] id: GO:0010228 name: vegetative to reproductive phase transition of meristem namespace: biological_process def: "The process involved in transforming a meristem that produces vegetative structures, such as leaves, into a meristem that produces reproductive structures, such as a flower or an inflorescence." [GOC:tb] synonym: "floral evocation" RELATED [DOI:10.1146/annurev.pp.39.060188.001135] synonym: "flowering" RELATED [] synonym: "transition from vegetative to reproductive phase" EXACT [] is_a: GO:0003006 ! reproductive developmental process relationship: part_of GO:0009791 ! post-embryonic development relationship: part_of GO:0048608 ! reproductive structure development [Term] id: GO:0010229 name: inflorescence development namespace: biological_process def: "The process whose specific outcome is the progression of an inflorescence over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048608 ! reproductive structure development [Term] id: GO:0010230 name: alternative respiration namespace: biological_process def: "Alternative respiration pathway consumes oxygen, oxidizes NADH to NAD+ and generates water. During electron flow, proton motive force is diminished resulting in fewer molecules of ATP compared to cytochrome pathway. The pathway is found in plants, algae and some protozoa." [ISBN:0943088399] is_a: GO:0045333 ! cellular respiration [Term] id: GO:0010231 name: maintenance of seed dormancy namespace: biological_process def: "Any process by which a dormant state is maintained in a seed." [PMID:9580097] is_a: GO:0009737 ! response to abscisic acid stimulus is_a: GO:0022611 ! dormancy process relationship: part_of GO:0010162 ! seed dormancy [Term] id: GO:0010232 name: vascular transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a vascular tissue or in the vascular membrane." [GOC:sm] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010233 name: phloem transport namespace: biological_process def: "The directed movement of substances, into, out of or within a cell, either in a phloem tissue or in the phloem membrane." [GOC:sm] is_a: GO:0010232 ! vascular transport [Term] id: GO:0010234 name: tapetal cell fate specification namespace: biological_process def: "The process by which a cell becomes capable of differentiating autonomously into a tapetal cell of anthers in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed." [GOC:mg] is_a: GO:0001708 ! cell fate specification is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048657 ! tapetal cell differentiation [Term] id: GO:0010235 name: guard mother cell cytokinesis namespace: biological_process def: "The stereotyped symmetric cell division by which guard mother cell give rise to stomatal guard cells." [GOC:tb] synonym: "guard mother cell division" EXACT [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010236 name: plastoquinone biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of plastoquinone, a lipid-soluble electron-transporting coenzyme present in the chloroplast." [GOC:sm] synonym: "plastoquinone anabolism" EXACT [] synonym: "plastoquinone biosynthesis" EXACT [] synonym: "plastoquinone formation" EXACT [] synonym: "plastoquinone synthesis" EXACT [] xref: MetaCyc:PWY-1581 is_a: GO:0045426 ! quinone cofactor biosynthetic process [Term] id: GO:0010238 name: response to proline namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a proline stimulus." [GOC:sm] is_a: GO:0043200 ! response to amino acid stimulus [Term] id: GO:0010239 name: chloroplast mRNA processing namespace: biological_process def: "Steps involved in processing precursor RNAs arising from transcription of operons in the chloroplast genome into mature mRNAs." [GOC:tb, PMID:9648738] is_a: GO:0006397 ! mRNA processing is_a: GO:0031425 ! chloroplast RNA processing [Term] id: GO:0010240 name: plastid pyruvate dehydrogenase complex namespace: cellular_component def: "Complex that carries out the oxidative decarboxylation of pyruvate to form acetyl-CoA; comprises subunits possessing three catalytic activities: pyruvate dehydrogenase (E1), dihydrolipoamide S-acetyltransferase (E2), and dihydrolipoamide dehydrogenase (E3). This complex is found in plant plastids and is distinct from the one found in mitochondria." [GOC:mtg_sensu, PMID:9393637] synonym: "dehydrogenase complex" BROAD [] is_a: GO:0044435 ! plastid part is_a: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: GO:0045254 ! pyruvate dehydrogenase complex intersection_of: part_of GO:0009536 ! plastid [Term] id: GO:0010241 name: ent-kaurene oxidase activity namespace: molecular_function def: "Catalysis of three successive oxidations of the 4-methyl group of ent-kaurene resulting in kaurenoic acid." [GOC:tb] synonym: "ent-kaur-16-ene,NADPH:oxygen oxidoreductase (hydroxylating) activity" EXACT [] xref: EC:1.14.13.78 xref: MetaCyc:1.14.13.78-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0010242 name: oxygen evolving activity namespace: molecular_function def: "Catalysis of the reaction: 2 H2O = O2 + 4 H+ + 4 e-. The evolution of oxygen from oxidizing water is carried out by the oxygen evolving complex in photosystem II of plants. P680+, the photochemically oxidized reaction-center chlorophyll of PSII, is a strong biological oxidant. The reduction potential of P680+ is more positive than that of water, and thus it can oxidize water to give O2 and H+ ions. The oxygen escapes as a gas while the H+ ions remain in solution inside the thylakoid vesicle." [GOC:kd, GOC:syr, PMID:17091926, PMID:7948862] synonym: "photosynthetic water oxidation" EXACT [] xref: MetaCyc:PSII-RXN xref: MetaCyc:RXN0-5265 is_a: GO:0016491 ! oxidoreductase activity [Term] id: GO:0010243 name: response to organic nitrogen namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic nitrogen stimulus. An organic nitrogen compound is formally a compound containing at least one carbon-nitrogen bond." [ChEBI:35352, PMID:9869419] synonym: "response to organonitrogen compound" EXACT [ChEBI:35352] is_a: GO:0009719 ! response to endogenous stimulus is_a: GO:0010033 ! response to organic substance [Term] id: GO:0010244 name: response to low fluence blue light stimulus by blue low-fluence system namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the detection of a low fluence blue light stimulus by the blue low-fluence system. Blue light is electromagnetic radiation with a wavelength of between 440 and 500nm. The blue low-fluence system responds to blue light at or below 0.1 micromols/m2. In certain species excitation of the blue low fluence system induces the transcription of a number of nuclear and plastid coded genes." [GOC:mtg_far_red, PMID:10398709] synonym: "response to low fluence blue light" BROAD [] synonym: "response to low fluence blue light by blf system" EXACT [] is_a: GO:0009637 ! response to blue light is_a: GO:0009645 ! response to low light intensity stimulus [Term] id: GO:0010245 name: radial microtubular system formation namespace: biological_process def: "Formation of radial microtubular systems during male meiotic cytokinesis in plants." [GOC:syr] is_a: GO:0000226 ! microtubule cytoskeleton organization [Term] id: GO:0010246 name: rhamnogalacturonan I biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan I component of pectin, a rhamnose-rich pectic polysaccharide." [GOC:pz] synonym: "rhamnogalacturonan I anabolism" EXACT [] synonym: "rhamnogalacturonan I biosynthesis" EXACT [] synonym: "rhamnogalacturonan I formation" EXACT [] synonym: "rhamnogalacturonan I synthesis" EXACT [] is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010247 name: detection of phosphate ion namespace: biological_process def: "The series of events in which a phosphate ion stimulus is received by a cell and converted into a molecular signal." [GOC:sm] synonym: "phosphate ion detection" EXACT [] synonym: "phosphate ion perception" RELATED [] synonym: "phosphate ion sensing" RELATED [] is_a: GO:0009593 ! detection of chemical stimulus [Term] id: GO:0010248 name: establishment or maintenance of transmembrane electrochemical gradient namespace: biological_process def: "The directed movement of ions to establish or maintain an electrochemical gradient across a membrane." [GOC:mah, GOC:sm] is_a: GO:0006810 ! transport [Term] id: GO:0010249 name: auxin conjugate metabolic process namespace: biological_process def: "The chemical reactions and pathways involving auxin conjugates, a bound form of auxin." [GOC:sm] synonym: "auxin conjugate metabolism" EXACT [] is_a: GO:0009850 ! auxin metabolic process [Term] id: GO:0010250 name: S-methylmethionine biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of S-methyl-methionine (SMM) from methionine and S-adenosyl-methionine (Ado-Met), catalyzed by methionine S-methyltransferase (MMT). SMM can be reconverted to methionine by donating a methyl group to homocysteine, and concurrent operation of this reaction and that mediated by MMT sets up the SMM cycle." [PMID:12692340] synonym: "S-methylmethionine anabolism" EXACT [] synonym: "S-methylmethionine biosynthesis" EXACT [] synonym: "S-methylmethionine formation" EXACT [] synonym: "S-methylmethionine synthesis" EXACT [] is_a: GO:0033477 ! S-methylmethionine metabolic process is_a: GO:0044272 ! sulfur compound biosynthetic process [Term] id: GO:0010252 name: auxin homeostasis namespace: biological_process def: "Maintenance of endogenous concentration of primary auxin steady-state, or constant level of auxin in a biological system by a number of biochemical processes including transport, biosynthesis, catabolism and conjugation." [http://diss-epsilon.slu.se/archive/00000215/] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010253 name: UDP-rhamnose biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of UDP-L-rhamnose, a substance composed of rhamnose in glycosidic linkage with uridine diphosphate." [PMID:15134748] synonym: "UDP-rhamnose anabolism" EXACT [] synonym: "UDP-rhamnose biosynthesis" EXACT [] synonym: "UDP-rhamnose formation" EXACT [] synonym: "UDP-rhamnose synthesis" EXACT [] xref: MetaCyc:PWY-3261 is_a: GO:0009226 ! nucleotide-sugar biosynthetic process is_a: GO:0019300 ! rhamnose biosynthetic process is_a: GO:0033478 ! UDP-rhamnose metabolic process [Term] id: GO:0010254 name: nectary development namespace: biological_process def: "The process whose specific outcome is the progression of the floral nectaries over time, from its formation to the mature structure." [GOC:lr] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0048856 ! anatomical structure development relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010255 name: glucose mediated signaling pathway namespace: biological_process def: "The process by which a change in the level of mono- and disaccharide glucose trigger the expression of genes controlling metabolic and developmental processes." [GOC:sm] synonym: "glucose mediated signalling" EXACT [] is_a: GO:0009757 ! hexose mediated signaling is_a: GO:0071333 ! cellular response to glucose stimulus [Term] id: GO:0010256 name: endomembrane system organization namespace: biological_process def: "A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endomembrane system." [GOC:mah, GOC:sm] synonym: "endomembrane organization" EXACT [GOC:curators] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0010257 name: NADH dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form an NADH dehydrogenase complex." [GOC:sm] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010258 name: NADH dehydrogenase complex (plastoquinone) assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NADH:plastoquinone dehydrogenase complex, which is involved in the non-photochemical reduction of plastoquinones, as well as the cyclic electron transport around photosystem I." [PMID:15608332] is_a: GO:0010257 ! NADH dehydrogenase complex assembly [Term] id: GO:0010259 name: multicellular organismal aging namespace: biological_process def: "The inherent decline of a multicellular organism over time, from the optimal fertility and viability of early maturity, that may precede death and may be preceded by other indications, such as sterility." [GOC:dph, GOC:isa_complete, GOC:mtg_sensu, GOC:sm] is_a: GO:0007568 ! aging relationship: part_of GO:0007275 ! multicellular organismal development [Term] id: GO:0010260 name: organ senescence namespace: biological_process alt_id: GO:0010261 def: "The process that occurs in an organ near the end of its active life that is associated with the dismantling of cell components and membranes, and an overall decline in metabolism. An example of this process is found in Arabidopsis thaliana." [GOC:mtg_sensu, GOC:sm] is_a: GO:0010149 ! senescence relationship: part_of GO:0048513 ! organ development [Term] id: GO:0010262 name: somatic embryogenesis namespace: biological_process def: "Initiation of a somatic embryo-an embryo arising from previously differentiated somatic cells, rather than from fused haploid gametes." [GOC:sm, PMID:9611173] is_a: GO:0009793 ! embryo development ending in seed dormancy [Term] id: GO:0010263 name: tricyclic triterpenoid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of tricyclic triterpenoid compounds, terpenoids with 6 isoprene units and 3 carbon rings." [GOC:ct] synonym: "tricyclic triterpenoid anabolism" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid biosynthesis" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid formation" EXACT [GOC:tair_curators] synonym: "tricyclic triterpenoid synthesis" EXACT [GOC:tair_curators] is_a: GO:0010683 ! tricyclic triterpenoid metabolic process is_a: GO:0016104 ! triterpenoid biosynthetic process [Term] id: GO:0010264 name: myo-inositol hexakisphosphate biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phytic acid, myo-inositol hexakisphosphate, a regulator of intracellular signaling, a highly abundant animal anti-nutrient and a phosphate and mineral storage compound in plant seeds." [ChEBI:17401, PMID:16107538] synonym: "myo-inositol hexakisphosphate anabolism" EXACT [] synonym: "myo-inositol hexakisphosphate biosynthesis" EXACT [] synonym: "myo-inositol hexakisphosphate formation" EXACT [] synonym: "myo-inositol hexakisphosphate synthesis" EXACT [] synonym: "phytate biosynthesis" EXACT [] synonym: "phytate biosynthetic process" EXACT [] is_a: GO:0032958 ! inositol phosphate biosynthetic process is_a: GO:0033517 ! myo-inositol hexakisphosphate metabolic process [Term] id: GO:0010265 name: SCF complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the SKP1-Cullin/Cdc53-F-box protein ubiquitin ligase (SCF) complex." [GOC:pz] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010266 name: response to vitamin B1 namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B1 stimulus." [GOC:pz] synonym: "response to thiamin" EXACT [] synonym: "response to thiamine" EXACT [] is_a: GO:0033273 ! response to vitamin [Term] id: GO:0010267 name: production of ta-siRNAs involved in RNA interference namespace: biological_process def: "Cleavage of double-stranded RNA to form trans-acting small interfering RNA molecules (siRNAs) of 21-23 nucleotides. ta-siRNAs arise from PolII genes and function like miRNAs to guide cleavage of target mRNAs." [GOC:tb, PMID:16129836] synonym: "RNA interference, production of ta-siRNAs" EXACT [GOC:mah] is_a: GO:0030422 ! production of siRNA involved in RNA interference [Term] id: GO:0010268 name: brassinosteroid homeostasis namespace: biological_process def: "Any process involved in the maintenance of an internal steady-state of brassinosteroids within an organism or cell." [PMID:15908602] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010269 name: response to selenium ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from selenium ion." [GOC:mg] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010270 name: photosystem II oxygen evolving complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form the oxygen evolving complex (OEC) of photosystem II on thylakoid membrane. In plants, the photosystem II OEC consists of three extrinsic nuclear-encoded polypeptides: PsbO, PsbP and PsbQ; and protects the CaMn4 cluster bound to D1 and CP43 proteins." [PMID:16282331] synonym: "OEC (PSII) ASSEMBLY" EXACT [PMID:16282331] is_a: GO:0010207 ! photosystem II assembly [Term] id: GO:0010271 name: regulation of chlorophyll catabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of chlorophyll." [PMID:16361392] is_a: GO:0031329 ! regulation of cellular catabolic process is_a: GO:0090056 ! regulation of chlorophyll metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015996 ! chlorophyll catabolic process relationship: regulates GO:0015996 ! chlorophyll catabolic process [Term] id: GO:0010272 name: response to silver ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a silver ion stimulus." [PMID:16367966] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010273 name: detoxification of copper ion namespace: biological_process def: "Any process that reduces or removes the toxicity of copper ion. These include transport of copper away from sensitive areas and to compartments or complexes whose purpose is sequestration of copper ion." [PMID:16367966] is_a: GO:0009636 ! response to toxin is_a: GO:0046688 ! response to copper ion [Term] id: GO:0010274 name: hydrotropism namespace: biological_process def: "Growth or movement in a sessile organism toward or away from water, as of the roots of a plant." [ISBN:0395825172] xref: Wikipedia:Hydrotropism is_a: GO:0009606 ! tropism [Term] id: GO:0010275 name: NAD(P)H dehydrogenase complex assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form NAD(P)H dehydrogenase complex, which is involved in electron transport from an unidentified electron donor, possibly NAD(P)H or ferredoxin(Fd) to the plastoquinone pool." [GOC:sm] synonym: "NAD(P)H dehydrogenase complex (plastoquinone) assembly" NARROW [] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010276 name: phytol kinase activity namespace: molecular_function def: "Catalysis of the reaction: phytol + CTP = phytylphosphate + CDP." [PMID:16361393] is_a: GO:0016301 ! kinase activity [Term] id: GO:0010277 name: chlorophyllide a oxygenase activity namespace: molecular_function alt_id: GO:0046407 def: "Catalysis of hydroxylation at the 7-methyl group of chlorophyllide a, according to the reactions: chlorophyllide a + O2 + NADPH + H+ = 7-hydroxychlorophyllide a + H2O + NADP+ and 7-hydroxychlorophyllide a + O2 + NADPH + H+ = chlorophyllide b + 2 H2O + NADP+." [EC:1.13.12.14, MetaCyc:RXN-7677] synonym: "CAO" RELATED [EC:1.13.12.14] synonym: "chlorophyll a oxygenase activity" EXACT [] synonym: "chlorophyll b synthetase activity" EXACT [] synonym: "chlorophyll-b synthase activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide a:oxygen 7-oxidoreductase activity" EXACT [EC:1.13.12.14] synonym: "chlorophyllide-a oxygenase activity" EXACT [EC:1.13.12.14] xref: EC:1.13.12.14 is_a: GO:0016703 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of one atom of oxygen (internal monooxygenases or internal mixed function oxidases) [Term] id: GO:0010278 name: chloroplast outer membrane translocon namespace: cellular_component def: "The protein transport machinery of the chloroplast outer membrane that contains at least three components Toc159, Toc75 and Toc34, interacts with precursor proteins which are imported into the chloroplast in a GTP dependant manner." [PMID:11299338] is_a: GO:0043234 ! protein complex is_a: GO:0044425 ! membrane part is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009707 ! chloroplast outer membrane [Term] id: GO:0010279 name: indole-3-acetic acid amido synthetase activity namespace: molecular_function def: "Catalysis of the reaction IAA + an amino acid = an IAA amide conjugate." [PMID:15659623] subset: gosubset_prok synonym: "IAA amido synthetase activity" EXACT [] synonym: "IAA amino acid conjugate synthetase activity" EXACT [GOC:kad] synonym: "IAA amino acid synthetase activity" EXACT [GOC:kad] is_a: GO:0016881 ! acid-amino acid ligase activity [Term] id: GO:0010280 name: UDP-L-rhamnose synthase activity namespace: molecular_function def: "Catalysis of the reaction UDP-D-glucose + NADPH = UDP-L-rhamnose + NADP+ + H2O." [GOC:tair_curators, PMID:14701918] synonym: "UDP-4-keto-6-deoxy-D-glucose 3,5-epimerase-4-reductase activity" NARROW [GOC:tb] is_a: GO:0003824 ! catalytic activity [Term] id: GO:0010282 name: senescence associated vacuole namespace: cellular_component def: "A lytic vacuole that is maintained at acidic pH and has different tonoplast composition compared to the central vacuole. Found during leaf senescence and develops in the peripheral cytoplasm of cells that contain chloroplast." [PMID:15743448] is_a: GO:0000323 ! lytic vacuole is_a: GO:0000325 ! plant-type vacuole [Term] id: GO:0010283 name: pinoresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: pinoresinol + NADPH = lariciresinol + NADP+." [PMID:10066819, PMID:7592828] is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010284 name: lariciresinol reductase activity namespace: molecular_function def: "Catalysis of the reaction: lariciresinol + NADPH = secoisolariciresinol + NADP+." [PMID:10066819, PMID:7592828] is_a: GO:0016628 ! oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [Term] id: GO:0010285 name: L,L-diaminopimelate aminotransferase activity namespace: molecular_function alt_id: GO:0043742 def: "Catalysis of the reaction: LL-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydropyridine-2,6-dicarboxylate + L-glutamate + H2O." [PMID:16361515] synonym: "LL-2,6-diaminoheptanedioate:2-oxoglutarate aminotransferase activity" EXACT [] synonym: "LL-DAP aminotransferase activity" EXACT [EC:2.6.1.83] synonym: "LL-DAP-AT activity" EXACT [EC:2.6.1.83] synonym: "LL-diaminopimelate aminotransferase activity" EXACT [] synonym: "LL-diaminopimelate transaminase activity" EXACT [EC:2.6.1.83] xref: EC:2.6.1.83 xref: MetaCyc:RXN-7737 is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010286 name: heat acclimation namespace: biological_process def: "Any process that increases heat tolerance of an organism in response to high temperatures." [GOC:tair_curators] is_a: GO:0009408 ! response to heat [Term] id: GO:0010287 name: plastoglobule namespace: cellular_component def: "Plastoglobules (PG) are lipoprotein particles present in chloroplasts. They are rich in non-polar lipids (triglycerides, esters) as well as in prenylquinones, plastoquinone and tocopherols. Plastoglobules are often associated with thylakoid membranes, suggesting an exchange of lipids with thylakoids." [GOC:tair_curators, PMID:16461379] is_a: GO:0044434 ! chloroplast part [Term] id: GO:0010288 name: response to lead ion namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lead ion stimulus." [GOC:tair_curators, PMID:16461380] is_a: GO:0010038 ! response to metal ion [Term] id: GO:0010289 name: homogalacturonan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of the pectidic homogalacturonan, characterized by a backbone of 1,4-linked alpha-D-GalpA residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [PMID:12913136, PMID:16540543] xref: MetaCyc:PWY-1061 is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010290 name: chlorophyll catabolite transmembrane transporter activity namespace: molecular_function def: "Enables the directed movement of chlorophyll catabolites such as non-fluorescent chlorophyll catabolites (NCCs), from one side of the membrane to the other." [PMID:9681016] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity [Term] id: GO:0010291 name: carotene beta-ring hydroxylase activity namespace: molecular_function alt_id: GO:0042411 def: "Catalysis of C3-hydroxylation of the beta-ring of various carotenes." [MetaCyc:MONOMER-12386, PMID:16492736] synonym: "beta-carotene hydroxylase activity" NARROW [] is_a: GO:0004497 ! monooxygenase activity [Term] id: GO:0010292 name: GTP:GDP antiporter activity namespace: molecular_function def: "Catalysis of the reaction: GTP(out) + GDP(in) = GTP(in) + GDP(out)." [PMID:10514379, PMID:12553910, PMID:16553903] is_a: GO:0015300 ! solute:solute antiporter activity [Term] id: GO:0010293 name: abscisic aldehyde oxidase activity namespace: molecular_function alt_id: GO:0033725 def: "Catalysis of the reaction: abscisic aldehyde + H2O + O2 = abscisate + H2O2." [EC:1.2.3.14, PMID:11050171] synonym: "AAO3" RELATED [EC:1.2.3.14] synonym: "abscisic-aldehyde oxidase activity" EXACT [EC:1.2.3.14] synonym: "abscisic-aldehyde:oxygen oxidoreductase activity" EXACT [EC:1.2.3.14] synonym: "AOdelta" RELATED [EC:1.2.3.14] xref: EC:1.2.3.14 xref: MetaCyc:1.2.3.14-RXN is_a: GO:0018488 ! aryl-aldehyde oxidase activity [Term] id: GO:0010294 name: abscisic acid glucosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: ABA + UDP-D-glucose = ABA-glucose ester + UDP." [DOI:10.1016/j.tetasy.2004.11.062] xref: MetaCyc:PWY-5272 is_a: GO:0035251 ! UDP-glucosyltransferase activity [Term] id: GO:0010295 name: (+)-abscisic acid 8'-hydroxylase activity namespace: molecular_function def: "Catalysis of the reaction: (+)-abscisate + NADPH + H+ + O2 = 8'-hydroxyabscisate + NADP+ + H2O." [EC:1.14.13.93] synonym: "(+)-ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-hydroxylase activity" EXACT [EC:1.14.13.93] synonym: "ABA 8'-Hydroxylase activity, Abscisate 8'-hydroxylase activity" RELATED [] synonym: "abscisate,NADPH:oxygen oxidoreductase (8'-hydroxylating)" EXACT [EC:1.14.13.93] synonym: "abscisic acid 8'-hydroxylase activity" EXACT [] xref: EC:1.14.13.93 xref: MetaCyc:1.14.13.93-RXN is_a: GO:0016709 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NADH or NADPH as one donor, and incorporation of one atom of oxygen [Term] id: GO:0010296 name: prenylcysteine methylesterase activity namespace: molecular_function def: "Catalysis of the reaction: protein prenyl L-cysteine methylester + H2O = protein L-cysteine + methanol." [PMID:16870359] is_a: GO:0051723 ! protein methylesterase activity [Term] id: GO:0010297 name: heteroglycan binding namespace: molecular_function def: "Interacting selectively and non-covalently with heteroglycans." [PMID:16640603] is_a: GO:0030247 ! polysaccharide binding [Term] id: GO:0010298 name: dihydrocamalexic acid decarboxylase activity namespace: molecular_function def: "Catalysis of the reaction: dihydrocamalexic acid = camalexin + CO2." [PMID:16766671] is_a: GO:0016831 ! carboxy-lyase activity [Term] id: GO:0010299 name: detoxification of cobalt ion namespace: biological_process def: "Any process that reduces or removes the toxicity of cobalt ion. These include transport of cobalt away from sensitive areas and to compartments or complexes whose purpose is sequestration of cobalt ion." [GOC:tair_curators] is_a: GO:0009636 ! response to toxin [Term] id: GO:0010301 name: xanthoxin dehydrogenase activity namespace: molecular_function alt_id: GO:0033710 def: "Catalysis of the reaction: xanthoxin + NAD+ = abscisic aldehyde + NADH + H+." [EC:1.1.1.288, PMID:12172025] synonym: "ABA2" RELATED [EC:1.1.1.288] synonym: "xanthoxin oxidase activity" EXACT [EC:1.1.1.288] synonym: "xanthoxin:NAD+ oxidoreductase activity" EXACT [EC:1.1.1.288] xref: EC:1.1.1.288 xref: MetaCyc:1.1.1.288-RXN is_a: GO:0004022 ! alcohol dehydrogenase (NAD) activity [Term] id: GO:0010302 name: 2-oxoglutarate-dependent dioxygenase activity namespace: molecular_function def: "Hydroxylase, with 2-oxoglutarate as one donor, and incorporation or reduction of one atom each of oxygen into both donors." [EC:1.14.11.-, PMID:16140259] is_a: GO:0016706 ! oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors [Term] id: GO:0010303 name: limit dextrinase activity namespace: molecular_function def: "Catalysis of the hydrolysis of (16)-alpha-D-glucosidic linkages in alpha- and beta-limit dextrins of amylopectin and glycogen, and in amylopectin and pullulan." [EC:3.2.1.142] synonym: "amylopectin-1,6-glucosidase activity" EXACT [EC:3.2.1.142] synonym: "dextrin alpha-1,6-glucanohydrolase activity" EXACT [EC:3.2.1.142] synonym: "R-enzyme" RELATED [EC:3.2.1.142] xref: EC:3.2.1.142 xref: MetaCyc:3.2.1.10-RXN xref: MetaCyc:3.2.1.142-RXN xref: MetaCyc:RXN-1824 is_a: GO:0004553 ! hydrolase activity, hydrolyzing O-glycosyl compounds [Term] id: GO:0010304 name: PSII associated light-harvesting complex II catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of one or more components of the light-harvesting complex of photosystem II." [GOC:mah, PMID:16157880] synonym: "LHCII catabolism" RELATED [] is_a: GO:0044257 ! cellular protein catabolic process [Term] id: GO:0010305 name: leaf vascular tissue pattern formation namespace: biological_process def: "Vascular tissue pattern formation as it occurs in the leaf of vascular plants." [GOC:tair_curators] is_a: GO:0010051 ! xylem and phloem pattern formation [Term] id: GO:0010306 name: rhamnogalacturonan II biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of rhamnogalacturonan II, a low molecular mass (5 - 10KDa) pectic polysaccharide, conserved in the primary walls of dicotyledenous and monocotyledenous plants and gymnosperms." [PMID:12754267] is_a: GO:0045489 ! pectin biosynthetic process [Term] id: GO:0010307 name: acetylglutamate kinase regulator activity namespace: molecular_function def: "Modulates the enzyme activity of acetylglutamate kinase." [PMID:16377628] is_a: GO:0019207 ! kinase regulator activity relationship: regulates GO:0003991 ! acetylglutamate kinase activity [Term] id: GO:0010308 name: acireductone dioxygenase (Ni2+-requiring) activity namespace: molecular_function def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 3-(methylthio)propanoate + formate + CO." [EC:1.13.11.53, PMID:16297065] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate- and CO-forming)" EXACT [EC:1.13.11.53] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.53] synonym: "ARD activity" RELATED [EC:1.13.11.53] synonym: "E-2 activity" RELATED [EC:1.13.11.53] xref: EC:1.13.11.53 is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010309 name: acireductone dioxygenase [iron(II)-requiring] activity namespace: molecular_function def: "Catalysis of reaction: 1,2-dihydroxy-5-(methylthio)pent-1-en-3-one + O2 = 4-(methylthio)-2-oxobutanoate + formate." [EC:1.13.11.54, PMID:16297065] subset: gosubset_prok synonym: "1,2-dihydroxy-3-keto-5-methylthiopentene dioxygenase activity" EXACT [] synonym: "1,2-dihydroxy-5-(methylthio)pent-1-en-3-one:oxygen oxidoreductase (formate-forming)" EXACT [EC:1.13.11.54] synonym: "2-hydroxy-3-keto-5-thiomethylpent-1-ene dioxygenase" BROAD [] synonym: "aci-reductone dioxygenase" BROAD [] synonym: "acireductone dioxygenase (Fe2+-requiring) activity" EXACT [] synonym: "acireductone dioxygenase activity" BROAD [EC:1.13.11.54] synonym: "ARD'" RELATED [] synonym: "ARD1" RELATED [] synonym: "E-2'" RELATED [] xref: EC:1.13.11.54 xref: MetaCyc:R147-RXN is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010310 name: regulation of hydrogen peroxide metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving hydrogen peroxide." [PMID:14765119] synonym: "regulation of hydrogen peroxide metabolism" EXACT [] is_a: GO:0080010 ! regulation of oxygen and reactive oxygen species metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0042743 ! hydrogen peroxide metabolic process relationship: regulates GO:0042743 ! hydrogen peroxide metabolic process [Term] id: GO:0010311 name: lateral root formation namespace: biological_process def: "The process that gives rise to a lateral root. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010102 ! lateral root morphogenesis [Term] id: GO:0010312 name: detoxification of zinc ion namespace: biological_process def: "Any process that reduces or removes the toxicity of zinc ion. These include transport of zinc away from sensitive areas and to compartments or complexes whose purpose is sequestration of zinc ion." [GOC:tair_curators] is_a: GO:0009636 ! response to toxin is_a: GO:0010043 ! response to zinc ion [Term] id: GO:0010313 name: phytochrome binding namespace: molecular_function def: "Interacting selectively and non-covalently with phytochrome." [PMID:15486102] is_a: GO:0005515 ! protein binding [Term] id: GO:0010314 name: phosphatidylinositol-5-phosphate binding namespace: molecular_function def: "Interacting selectively and non-covalently with phosphatidylinositol-5-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 5' position." [GOC:bf, GOC:tair_curators] is_a: GO:0035091 ! phosphoinositide binding [Term] id: GO:0010315 name: auxin efflux namespace: biological_process def: "The process involved in the transport of auxin out of the cell." [GOC:tair_curators] synonym: "auxin export" EXACT [] is_a: GO:0060918 ! auxin transport relationship: part_of GO:0009734 ! auxin mediated signaling pathway [Term] id: GO:0010316 name: pyrophosphate-dependent phosphofructokinase complex namespace: cellular_component def: "Heterodimeric complex that catalyzes the pyrophosphate-dependent phosphorylation of D-fructose 6-phosphate into D-fructose 1,6-bisphosphate." [PMID:2170409] subset: goslim_pir synonym: "PFK complex" RELATED [] is_a: GO:0043234 ! protein complex [Term] id: GO:0010317 name: pyrophosphate-dependent phosphofructokinase complex, alpha-subunit complex namespace: cellular_component def: "Refers to the alpha subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, alpha-subunit" RELATED [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010318 name: pyrophosphate-dependent phosphofructokinase complex, beta-subunit complex namespace: cellular_component def: "Refers to the beta subunit of the heterodimeric complex that possesses pyrophosphate-dependent phosphofructokinase activity." [PMID:2170409] synonym: "PFK complex, beta-subunit" RELATED [] is_a: GO:0043234 ! protein complex relationship: part_of GO:0010316 ! pyrophosphate-dependent phosphofructokinase complex [Term] id: GO:0010319 name: stromule namespace: cellular_component def: "Thin filamentous structure extending from the surface of all plastid types examined so far, including chloroplast, proplastid, etioplast, leucoplast, amyloplast, and chromoplast. In general, stromules are more abundant in tissues containing non-green plastids, and in cells containing smaller plastids. The primary function of stromules is still unresolved, although the presence of stromules markedly increases the plastid surface area, potentially increasing transport to and from the cytosol. Other functions of stromules, such as transfer of macromolecules between plastids and starch granule formation in cereal endosperm, may be restricted to particular tissues and cell types." [PMID:15272881, PMID:15699062, PMID:16582010] synonym: "Stroma-filled tubule" RELATED [] xref: Wikipedia:Stromule is_a: GO:0044435 ! plastid part relationship: part_of GO:0009526 ! plastid envelope [Term] id: GO:0010320 name: arginine/lysine endopeptidase activity namespace: molecular_function def: "OBSOLETE. Catalysis of the hydrolysis of peptide linkages in oligopeptides or polypeptides by a reaction mechanism in which arginine or lysine residues act as nucleophiles." [GOC:tair_curators] comment: This term was made obsolete because it was defined incorrectly: there are no known peptidases using a catalytic mechanism involving arginine and lysine, and the Arabidopsis metacaspases that prompted addition of this term are in fact cysteine-type endopeptidases. is_obsolete: true replaced_by: GO:0004175 replaced_by: GO:0004197 [Term] id: GO:0010321 name: regulation of vegetative phase change namespace: biological_process def: "Any process that modulates the frequency, rate or extent of vegetative phase change. Vegetative phase change is the set of post-embryonic processes involved in the transition of a plant from a juvenile phase of vegetative development to an adult phase of vegetative development." [GOC:tair_curators] is_a: GO:0048580 ! regulation of post-embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010050 ! vegetative phase change relationship: regulates GO:0010050 ! vegetative phase change [Term] id: GO:0010322 name: regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway relationship: regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway [Term] id: GO:0010323 name: negative regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of isopentenyl diphosphate produced via the methylerythritol (MEP) pathway (mevalonate-independent)." [PMID:16531478] synonym: "down regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "down-regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "downregulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" EXACT [] synonym: "inhibition of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway" NARROW [] is_a: GO:0010322 ! regulation of isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway is_a: GO:0010677 ! negative regulation of cellular carbohydrate metabolic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway relationship: negatively_regulates GO:0019288 ! isopentenyl diphosphate biosynthetic process, mevalonate-independent pathway [Term] id: GO:0010324 name: membrane invagination namespace: biological_process def: "The infolding of a membrane, resulting in formation of a vesicle." [GOC:tb] is_a: GO:0016044 ! cellular membrane organization [Term] id: GO:0010325 name: raffinose family oligosaccharide biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of raffinose family oligosaccharides (RFOs, such as raffinose, stachyose, verbascose and other molecules with a higher degree of galactosyl polymerization)." [GOC:tair_curators] synonym: "raffinose family oligosaccharide biosynthesis" EXACT [] is_a: GO:0009312 ! oligosaccharide biosynthetic process [Term] id: GO:0010326 name: methionine-oxo-acid transaminase activity namespace: molecular_function def: "Catalyzes the reaction: methionine + a 2-oxo acid = 4-methylthio-2-oxobutyrate + an amino acid." [PMID:17056707] is_a: GO:0008483 ! transaminase activity [Term] id: GO:0010327 name: acetyl CoA:(Z)-3-hexen-1-ol acetyltransferase activity namespace: molecular_function def: "Catalyzes the reaction: acetyl-CoA + (Z)-3-hexen-1-ol = CoA + (Z)-3-hexen-1-yl acetate." [PMID:17163883] synonym: "hexenol acetyltransferase" RELATED [] is_a: GO:0016413 ! O-acetyltransferase activity [Term] id: GO:0010328 name: auxin influx transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, into a cell." [PMID:16839804] synonym: "auxin influx facilitator" RELATED [] is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0060919 ! auxin influx [Term] id: GO:0010329 name: auxin efflux transmembrane transporter activity namespace: molecular_function def: "Catalysis of the transfer of auxin, from one side of a membrane to the other, out of a cell." [PMID:16839804] synonym: "auxin efflux carrier" RELATED [] synonym: "auxin efflux facilitator" RELATED [] is_a: GO:0015562 ! efflux transmembrane transporter activity is_a: GO:0022891 ! substrate-specific transmembrane transporter activity relationship: part_of GO:0010315 ! auxin efflux [Term] id: GO:0010330 name: cellulose synthase complex namespace: cellular_component def: "The multimeric protein complex, organized in a rosette, which catalyzes the biosynthesis of cellulose for the plant cell wall." [PMID:12514238] is_a: GO:0043234 ! protein complex [Term] id: GO:0010331 name: gibberellin binding namespace: molecular_function def: "Interacting selectively and non-covalently with gibberellins, plant hormones that regulate aspects of plant growth." [GOC:tair_curators] synonym: "gibberellic acid receptor" RELATED [] synonym: "gibberellin receptor" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0031406 ! carboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010332 name: response to gamma radiation namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gamma radiation stimulus. Gamma radiation is a form of electromagnetic radiation (EMR) or light emission of a specific frequency produced from sub-atomic particle interaction, such as electron-positron annihilation and radioactive decay. Gamma rays are generally characterized as EMR having the highest frequency and energy, and also the shortest wavelength, within the electromagnetic radiation spectrum." [GOC:tair_curators, Wikipedia:Gamma_ray] synonym: "response to gamma ray" RELATED [] synonym: "response to gamma-ray photon" RELATED [] is_a: GO:0010212 ! response to ionizing radiation [Term] id: GO:0010333 name: terpene synthase activity namespace: molecular_function def: "Catalyzing the formation of cyclic terpenes through the cyclization of linear terpenes containing varying quantities of isoprene units (i.e. isopentenyl-PP, geranyl-PP, farnesyl-PP and geranylgeranyl-PP)." [EC:4.2.3., GOC:tair_curators] is_a: GO:0016838 ! carbon-oxygen lyase activity, acting on phosphates [Term] id: GO:0010334 name: sesquiterpene synthase activity namespace: molecular_function def: "Catalyzing the formation of sesquiterpenes (terpene containing 15 carbons, i.e. three isoprene units) through the cyclization of trans,trans-farnesyl diphosphate (an allylic prenyl diphosphate intermediates of the terpene biosynthesis pathway)." [EC:4.2.3.-, GOC:tair_curators] is_a: GO:0010333 ! terpene synthase activity [Term] id: GO:0010335 name: response to non-ionic osmotic stress namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating an increase or decrease in the concentration of non-ionic solutes (e.g. mannitol, sorbitol) in the environment." [GOC:tair_curators] is_a: GO:0006970 ! response to osmotic stress [Term] id: GO:0010336 name: gibberellic acid homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady-state of gibberellic acid; may involve transport, biosynthesis, catabolism or conjugation." [PMID:17194763] synonym: "gibberellin homeostasis" BROAD [] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010337 name: regulation of salicylic acid metabolic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving salicylic acid." [PMID:14765119] synonym: "regulation of salicylic acid metabolism" RELATED [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009696 ! salicylic acid metabolic process relationship: regulates GO:0009696 ! salicylic acid metabolic process [Term] id: GO:0010338 name: leaf formation namespace: biological_process def: "The process that gives rise to a leaf. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tair_curators] is_a: GO:0048645 ! organ formation relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010339 name: external side of cell wall namespace: cellular_component def: "The side of the cell wall that is opposite to the side that faces the cell and its contents." [GOC:mtg_sensu, GOC:tb] is_a: GO:0044426 ! cell wall part relationship: part_of GO:0009986 ! cell surface [Term] id: GO:0010340 name: carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester." [PMID:17220201] is_a: GO:0008171 ! O-methyltransferase activity [Term] id: GO:0010341 name: gibberellin carboxyl-O-methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + GA = S-adenosyl-L-homocysteine + GA methyl ester." [PMID:17220201] is_a: GO:0010340 ! carboxyl-O-methyltransferase activity [Term] id: GO:0010342 name: cellularization of endosperm namespace: biological_process def: "The separation of the multi-nucleate endosperm into individual cells. In many plant species, the endosperm that nurtures the embryo in the seed initially develops as a syncytium. This syncytial phase ends with simultaneous partitioning of the multi-nucleate cytoplasm into individual cells, a process referred to as cellularization." [PMID:12421698] synonym: "endosperm cellularization" EXACT [] is_a: GO:0007349 ! cellularization [Term] id: GO:0010343 name: singlet oxygen-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by singlet oxygen. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:17075038] synonym: "light-dependent programmed cell death" BROAD [] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0010344 name: seed oilbody biogenesis namespace: biological_process def: "The cellular process by which an seed oilbody is synthesized, aggregates, and bonds together. Seed oilbodies are simple organelles comprising a matrix of triglyceride surrounded by a phospholipid monolayer embedded and covered with unique proteins called oleosins. Seed oilbodies supply the energy requirements for the growth of the seedling after germination." [GOC:jl, PMID:16877495] synonym: "oleosome biogenesis" RELATED [] synonym: "seed oil body organization" EXACT [] synonym: "spherosome biogenesis" RELATED [] is_a: GO:0044085 ! cellular component biogenesis is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010345 name: suberin biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of suberin monomers and suberin polyesters. Suberin monomers are derived from fatty acids and trans-cinnamic acids. The monomers are then cross-linked with glycerols." [PMID:17259262] xref: MetaCyc:PWY-1121 is_a: GO:0006631 ! fatty acid metabolic process is_a: GO:0009699 ! phenylpropanoid biosynthetic process [Term] id: GO:0010346 name: shoot formation namespace: biological_process def: "The process that gives rise to a shoot. This process pertains to the initial formation of a structure from unspecified parts." [GOC:tb] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010016 ! shoot morphogenesis [Term] id: GO:0010347 name: L-galactose-1-phosphate phosphatase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose-1-phosphate + H2O = L-galactose + phosphate." [PMID:15550539, PMID:16595667] xref: MetaCyc:RXNQT-4142 is_a: GO:0070456 ! galactose-1-phosphate phosphatase activity [Term] id: GO:0010348 name: lithium:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Li+(in) + H+(out) = Li+(out) + H+(in)." [PMID:17270011] synonym: "lithium:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0005451 ! monovalent cation:hydrogen antiporter activity [Term] id: GO:0010349 name: L-galactose dehydrogenase activity namespace: molecular_function def: "Catalysis of the reaction: L-galactose + NAD+ = L-galactono-1,4-lactone + NADH + H+." [PMID:12047629] synonym: "L-galactose 1-dehydrogenase activity" RELATED [] xref: MetaCyc:RXN-1884 is_a: GO:0016646 ! oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor [Term] id: GO:0010350 name: cellular response to magnesium starvation namespace: biological_process def: "A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of magnesium." [PMID:17270009] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010351 name: lithium ion transport namespace: biological_process def: "The directed movement of lithium ion into, out of, within or between cells by means of some external agent such as a transporter or pore." [PMID:17270011] synonym: "lithium transport" EXACT [] is_a: GO:0015672 ! monovalent inorganic cation transport [Term] id: GO:0010352 name: lithium ion export namespace: biological_process def: "The directed movement of lithium ion out of a cell or organelle." [PMID:17270011] synonym: "lithium export" EXACT [] synonym: "lithium ion efflux" RELATED [] is_a: GO:0010351 ! lithium ion transport [Term] id: GO:0010353 name: response to trehalose stimulus namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trehalose stimulus." [PMID:17031512] is_a: GO:0034285 ! response to disaccharide stimulus [Term] id: GO:0010354 name: homogentisate prenyltransferase activity namespace: molecular_function def: "Catalysis of the transfer of a prenyl group from one compound (donor) to homogentisic acid." [PMID:16989822] is_a: GO:0004659 ! prenyltransferase activity [Term] id: GO:0010355 name: homogentisate farnesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + farnesyl diphosphate -> 2-methyl-6-farnesylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010356 name: homogentisate geranylgeranyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + geranylgeranyl diphosphate -> 2-methyl-6-geranylgeranylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010357 name: homogentisate solanesyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: homogentisic acid + solanesyl diphosphate -> 2-methyl-6-solanesylplastoquinol." [PMID:16989822] is_a: GO:0010354 ! homogentisate prenyltransferase activity [Term] id: GO:0010358 name: leaf shaping namespace: biological_process def: "The developmental process that pertains to the organization of a leaf in three-dimensional space once the structure has initially formed." [GOC:tb, PMID:16971475] synonym: "leaf structural organization" RELATED [] is_a: GO:0048532 ! anatomical structure arrangement relationship: part_of GO:0009965 ! leaf morphogenesis [Term] id: GO:0010359 name: regulation of anion channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of anion channel activity." [PMID:17319842] subset: gosubset_prok is_a: GO:0032412 ! regulation of ion transmembrane transporter activity is_a: GO:0044070 ! regulation of anion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0005253 ! anion channel activity relationship: regulates GO:0005253 ! anion channel activity [Term] id: GO:0010360 name: negative regulation of anion channel activity namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] is_a: GO:0010359 ! regulation of anion channel activity is_a: GO:0032413 ! negative regulation of ion transmembrane transporter activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0005253 ! anion channel activity relationship: negatively_regulates GO:0005253 ! anion channel activity [Term] id: GO:0010361 name: regulation of anion channel activity by blue light namespace: biological_process def: "Any process by which the blue light modulates the frequency, rate or extent of anion channel activity." [GOC:dph, GOC:tb, PMID:17319842] synonym: "regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010359 ! regulation of anion channel activity [Term] id: GO:0010362 name: negative regulation of anion channel activity by blue light namespace: biological_process def: "Any process by which the blue light stops, prevents or reduces the frequency, rate, or extent of the anion channel activity." [PMID:17319842] synonym: "inhibition by blue light of anion channel activity" NARROW [] synonym: "negative regulation by blue light of anion channel activity" EXACT [GOC:dph, GOC:tb] is_a: GO:0010360 ! negative regulation of anion channel activity is_a: GO:0010361 ! regulation of anion channel activity by blue light [Term] id: GO:0010363 name: regulation of plant-type hypersensitive response namespace: biological_process def: "Any endogenous process that modulates the frequency, rate or extent of the plant hypersensitive response." [PMID:16255244] comment: Note that term is to be used to annotate gene products in the plant. To annotate genes in a symbiont, consider the biological process term 'modulation by symbiont of host programmed cell death ; GO:0052040'. synonym: "regulation of HR" EXACT [] synonym: "regulation of HR-PCD" EXACT [] synonym: "regulation of plant hypersensitive response" EXACT [] is_a: GO:0043067 ! regulation of programmed cell death is_a: GO:0045088 ! regulation of innate immune response is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009626 ! plant-type hypersensitive response relationship: regulates GO:0009626 ! plant-type hypersensitive response [Term] id: GO:0010364 name: regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate, or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0031335 ! regulation of sulfur amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009693 ! ethylene biosynthetic process relationship: regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010365 name: positive regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that activates or increases the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0031337 ! positive regulation of sulfur amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009693 ! ethylene biosynthetic process relationship: positively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010366 name: negative regulation of ethylene biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of an ethylene biosynthetic process." [GOC:tair_curators] is_a: GO:0010364 ! regulation of ethylene biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0031336 ! negative regulation of sulfur amino acid metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009693 ! ethylene biosynthetic process relationship: negatively_regulates GO:0009693 ! ethylene biosynthetic process [Term] id: GO:0010367 name: extracellular isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in animals are localized in the extracellular space." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0043033 ! isoamylase complex is_a: GO:0044421 ! extracellular region part intersection_of: GO:0043033 ! isoamylase complex intersection_of: part_of GO:0005576 ! extracellular region [Term] id: GO:0010368 name: chloroplast isoamylase complex namespace: cellular_component def: "A protein complex whose composition varies amongst species; in rice it probably exists in a homo-tetramer to homo-hexamer form and in Gram negative bacteria as a dimer. Functions in the hydrolysis of alpha-(1,6)-D-glucosidic branch linkages. Isoamylases in plants are intracellular and probably chloroplast localized." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0043033 ! isoamylase complex is_a: GO:0044434 ! chloroplast part intersection_of: GO:0043033 ! isoamylase complex intersection_of: part_of GO:0009507 ! chloroplast [Term] id: GO:0010369 name: chromocenter namespace: cellular_component def: "A region in which centric, heterochromatic portions of one or more chromosomes form a compact structure." [PMID:12384572, PMID:15053486, PMID:16831888] is_a: GO:0044427 ! chromosomal part [Term] id: GO:0010370 name: perinucleolar chromocenter namespace: cellular_component def: "A chromocenter adjacent to the nucleolus." [PMID:15805479] is_a: GO:0010369 ! chromocenter [Term] id: GO:0010371 name: regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0019747 ! regulation of isoprenoid metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process is_a: GO:0046890 ! regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0009686 ! gibberellin biosynthetic process relationship: regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010372 name: positive regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that activates, maintains or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "positive regulation of gibberellic acid biosynthetic process " NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0031328 ! positive regulation of cellular biosynthetic process is_a: GO:0045828 ! positive regulation of isoprenoid metabolic process is_a: GO:0046889 ! positive regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0009686 ! gibberellin biosynthetic process relationship: positively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010373 name: negative regulation of gibberellin biosynthetic process namespace: biological_process def: "Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of gibberellins." [GOC:tair_curators] synonym: "negative regulation of gibberellic acid biosynthetic process" NARROW [] is_a: GO:0010371 ! regulation of gibberellin biosynthetic process is_a: GO:0031327 ! negative regulation of cellular biosynthetic process is_a: GO:0045827 ! negative regulation of isoprenoid metabolic process is_a: GO:0051055 ! negative regulation of lipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0009686 ! gibberellin biosynthetic process relationship: negatively_regulates GO:0009686 ! gibberellin biosynthetic process [Term] id: GO:0010374 name: stomatal complex development namespace: biological_process def: "The process whose specific outcome is the progression of the stomatal complex over time from its formation to the mature structure. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0009791 ! post-embryonic development is_a: GO:0048856 ! anatomical structure development [Term] id: GO:0010375 name: stomatal complex patterning namespace: biological_process def: "The regionalization process of establishing the non-random spatial arrangement of stomatal complex on the surface of a leaf. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0003002 ! regionalization [Term] id: GO:0010376 name: stomatal complex formation namespace: biological_process def: "The process that gives rise to the stomatal complex. This process pertains to the initial formation of a structure from unspecified parts. The stomatal complex is the stomatal guard cells and their associated epidermal cells." [PMID:17259259] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010103 ! stomatal complex morphogenesis [Term] id: GO:0010377 name: guard cell fate commitment namespace: biological_process def: "The process whereby the developmental fate of a cell becomes restricted such that it will develop into a stomatal guard cell. Guard cells are located in the leaf epidermis and pairwise surround stomatal pores, which allow CO2 influx for photosynthetic carbon fixation and water loss via transpiration to the atmosphere." [PMID:17259259] synonym: "stomatal cell fate commitment" RELATED [] is_a: GO:0045165 ! cell fate commitment relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010378 name: temperature compensation of the circadian clock namespace: biological_process def: "The process by which the circadian clock maintains robust and accurate timing over a broad range of physiological temperatures. The circadian clock is an endogenous 24-h timer found in most eukaryotes and in photosynthetic bacteria. The clock drives rhythms in the physiology, biochemistry, and metabolism of the organisms." [PMID:16617099] subset: gosubset_prok synonym: "regulation of the circadian clock by temperature" RELATED [] is_a: GO:0009266 ! response to temperature stimulus is_a: GO:0042752 ! regulation of circadian rhythm [Term] id: GO:0010379 name: phaseic acid biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of phaseic acid (PA), a catabolite of the plant hormone abscisic acid (ABA)." [BioCyc:PWY-5271 "http://biocyc.org/META/NEW-IMAGE?type=PATHWAY&object=PWY-5271&detail-level=3"] xref: MetaCyc:PWY-5271 is_a: GO:0016106 ! sesquiterpenoid biosynthetic process is_a: GO:0046394 ! carboxylic acid biosynthetic process [Term] id: GO:0010380 name: regulation of chlorophyll biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors." [PMID:17291312] is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0090056 ! regulation of chlorophyll metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0015995 ! chlorophyll biosynthetic process relationship: regulates GO:0015995 ! chlorophyll biosynthetic process [Term] id: GO:0010381 name: attachment of peroxisome to chloroplast namespace: biological_process def: "The process by which a peroxisome is transported to, and/or maintained in, a location adjacent to the chloroplast." [PMID:17215364] is_a: GO:0051640 ! organelle localization [Term] id: GO:0010382 name: cellular cell wall macromolecule metabolic process namespace: biological_process def: "The chemical reactions and pathways involving macromolecules forming, or destined to form, part of a cell wall. A cell wall is a rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis, occurring at the level of the cell." [GOC:mah, GOC:tair_curators] subset: gosubset_prok synonym: "cellular cell wall macromolecule metabolism" EXACT [] is_a: GO:0044036 ! cell wall macromolecule metabolic process is_a: GO:0044260 ! cellular macromolecule metabolic process is_a: GO:0070882 ! cellular cell wall organization or biogenesis [Term] id: GO:0010383 name: cell wall polysaccharide metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall polysaccharides." [GOC:tair_curators] subset: gosubset_prok is_a: GO:0005976 ! polysaccharide metabolic process is_a: GO:0044036 ! cell wall macromolecule metabolic process [Term] id: GO:0010384 name: cell wall proteoglycan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving cell wall peptidoglycan, a group of glycoproteins that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall proteoglycan metabolism" EXACT [] is_a: GO:0006029 ! proteoglycan metabolic process is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process [Term] id: GO:0010385 name: double-stranded methylated DNA binding namespace: molecular_function def: "Interacting selectively and non-covalently with double-stranded methylated DNA. Cytosine methylation in DNA is an important mechanism for establishing stable heritable epigenetic marks." [PMID:17242155] is_a: GO:0003690 ! double-stranded DNA binding [Term] id: GO:0010386 name: lateral root primordium development namespace: biological_process def: "The process whose specific outcome is the progression of the lateral root primordium over time, which initiates the formation to the mature structure. A lateral root primordium represents an organized group of cells derived from the root pericycle that will differentiate into a new root, as opposed to the initiation of the main root from the embryo proper." [PMID:17259263] is_a: GO:0048527 ! lateral root development [Term] id: GO:0010387 name: signalosome assembly namespace: biological_process def: "The aggregation, arrangement and bonding together of a set of components to form a signalosome." [PMID:17307927] is_a: GO:0043623 ! cellular protein complex assembly [Term] id: GO:0010388 name: cullin deneddylation namespace: biological_process def: "The modification of cullins by removal of ubiquitin-like protein NEDD8 (RUB1)." [PMID:17307927] is_a: GO:0000338 ! protein deneddylation [Term] id: GO:0010389 name: regulation of G2/M transition of mitotic cell cycle namespace: biological_process def: "Any process that modulates the rate or extent of progression from G2 phase to M phase of the mitotic cell cycle." [PMID:17329565] synonym: "regulation of mitotic entry" EXACT [GOC:vw] is_a: GO:0007346 ! regulation of mitotic cell cycle is_a: GO:0010564 ! regulation of cell cycle process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0000086 ! G2/M transition of mitotic cell cycle relationship: regulates GO:0000086 ! G2/M transition of mitotic cell cycle [Term] id: GO:0010390 name: histone monoubiquitination namespace: biological_process def: "The modification of histones by addition of a single ubiquitin moiety." [PMID:17329563] is_a: GO:0006513 ! protein monoubiquitination is_a: GO:0016574 ! histone ubiquitination [Term] id: GO:0010391 name: glucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving glucomannan, a polysaccharide composed of D-glucose and D-mannose. The mannose units form the backbone structure (a linear main chain) with the D-glucose as single side-units." [GOC:tair_curators] synonym: "glucomannan metabolism" EXACT [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010392 name: galactoglucomannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactoglucomannan, a polysaccharide composed of D-glucose, D-galactose and D-mannose. The mannose units form the backbone structure (a linear main chain) decorated with a mixture of D-glucose and D-galactose side-units." [GOC:tair_curators] synonym: "galactoglucomannan metabolism" RELATED [] is_a: GO:0006080 ! substituted mannan metabolic process [Term] id: GO:0010393 name: galacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galacturonan, a pectin polymer containing a backbone of alpha-(1->4)-linked D-galacturonic acid residues." [GOC:tair_curators] synonym: "galacturonan metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010394 name: homogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving homogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues that can be methyl-esterified at C-6 and carry acetyl groups on O-2 and O-3." [GOC:tair_curators] synonym: "homogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010395 name: rhamnogalacturonan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan I (RGI), a branched pectin with a backbone of alternating alpha-(1->2)-linked rhamnose and alpha-(1->4)-linked D-galacturonic acid residues that carries neutral side-chains of predominantly beta-(1->4)-D-galactose and/or alpha-(1->5)-L-arabinose residues attached to the rhamnose residues of the RGI backbone." [GOC:tair_curators] synonym: "RGI metabolism" RELATED [] synonym: "rhamnogalacturonan I metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process is_a: GO:0052546 ! cell wall pectin metabolic process [Term] id: GO:0010396 name: rhamnogalacturonan II metabolic process namespace: biological_process def: "The chemical reactions and pathways involving rhamnogalacturonan II, a low molecular mass (5-10KDa) pectic polysaccharide. The backbone of RG-II contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010397 name: apiogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the pectic apiogalacturonan, characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted with apiose and apiobiose (D-apiofuranosyl-beta-(l->3)-D-apiose) side chains via O-2 or O-3 links." [GOC:tair_curators] synonym: "apiogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010398 name: xylogalacturonan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylogalacturonan, a pectin characterized by a backbone of alpha-(1->4)-linked D-galacturonic acid residues substituted on C-3 with beta-D-xylopyranose residues." [GOC:tair_curators] synonym: "xylogalacturonan metabolism" EXACT [] is_a: GO:0010393 ! galacturonan metabolic process [Term] id: GO:0010399 name: rhamnogalacturonan I backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the alternating alpha-(1->2)-linked rhamnose and alpha-(1->2)-linked B-galacturonic acid residues of the rhamnogalacturonan I backbone." [GOC:tair_curators] synonym: "rhamnogalacturonan I backbone metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010400 name: rhamnogalacturonan I side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of the pectin, rhamnogalacturonan I." [GOC:tair_curators] synonym: "rhamnogalacturonan I side chain metabolism" EXACT [] is_a: GO:0010395 ! rhamnogalacturonan I metabolic process [Term] id: GO:0010401 name: pectic galactan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving galactan, a polymer of D-galactosyl units that can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic galactan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010402 name: pectic arabinan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving arabinan, a polymer with an alpha-(1->5)-linked -L-arabinofuranose (Araf) backbone that can be substituted with Araf-alpha-(1->2)-, Araf-alpha-(1->3)-, and/or Araf-alpha-(1->3)-Araf-alpha-(1->3)-side chains. Arabinan can be found as a side chain of the pectin rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinan metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process is_a: GO:0031221 ! arabinan metabolic process [Term] id: GO:0010403 name: pectic arabinogalactan I metabolic process namespace: biological_process def: "The chemical reactions and pathways involving pectic arabinogalactan I, an alpha-(1->4)-linked D-galactopyranose backbone that is substituted with alpha-l-Araf residues via the O-3 of the D-galactose residues. Arabinogalactan I can be found as a side chain of rhamnogalacturonan I." [GOC:tair_curators] synonym: "pectic arabinogalactan I metabolism" EXACT [] is_a: GO:0010400 ! rhamnogalacturonan I side chain metabolic process [Term] id: GO:0010404 name: cell wall hydroxyproline-rich glycoprotein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall hydroxyproline-rich glycoprotein that consist of a core-protein backbone O-glycosylated by one or more complex carbohydrates." [GOC:tair_curators] synonym: "cell wall hydroxyproline-rich glycoprotein metabolism" EXACT [] is_a: GO:0010384 ! cell wall proteoglycan metabolic process [Term] id: GO:0010405 name: arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein of highly varying length and domain complexity. These are O-glycosylated at one or more hydroxyproline residues by arabinogalactan (AG) type II groups, which consist of (1->3)-beta-galactan and (1->6)-beta-linked galactan chains connected to each other by (1->3,1->6)-linked branch points, O-3 and O-6 positions substituted with terminal arabinosyl residues. Also, rhamnose, fucose, glucuronic and galacturonic acid can be present in the glycan structures." [GOC:tair_curators] synonym: "arabinogalactan protein metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010406 name: classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein, which is composed of a group of core protein containing Hyp, Ala, Ser, Thr and Gly as the major amino acid constituents, and the C-terminus is GPI anchored." [GOC:tair_curators] synonym: "classical-arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010407 name: non-classical arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving a cell wall arabinogalactan II glycoprotein where other amino acids besides Hyp, Ala, Ser, Thr and Gly can be present and grouped into regions, such as a Cys-rich or Asn-rich domains." [GOC:tair_curators] synonym: "non-classical arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010408 name: fasciclin-like arabinogalactan protein metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the cell wall arabinogalactan II glycoprotein variant which contains both an arabinogalactan protein (AGP) motif and a fasciclin domain." [GOC:tair_curators] synonym: "fasciclin-like arabinogalactan protein metabolism" EXACT [] is_a: GO:0010405 ! arabinogalactan protein metabolic process [Term] id: GO:0010409 name: extensin metabolic process namespace: biological_process def: "The chemical reactions and pathways involving extensins, a group of 60-90 kDNA hydroxyproline (Hyp)-rich glycoproteins whose polypeptide backbone consists of many repeats of structural Ser(Hyp)4-6 motifs, with heavily glycosylated 1-4 arabinose residues O-linked to contiguous stretches of Hyp residues, with most of the Ser residues being O-galactosylated." [GOC:tair_curators] synonym: "extensin metabolism" EXACT [] is_a: GO:0010404 ! cell wall hydroxyproline-rich glycoprotein metabolic process [Term] id: GO:0010410 name: hemicellulose metabolic process namespace: biological_process def: "The chemical reactions and pathways involving hemicelluloses, plant cell wall polysaccharides that have a backbone of 1,4-linked beta-D-pyranosyl residues in which O4 is in the equatorial orientation. Many different hemicelluloses usually occur intermixed with each molecular type representing different degrees of polymerization and contain many different sugar monomers, which can include glucose, xylose, mannose, galactose, and arabinose. Hemicelluloses also contain most of the D-pentose sugars and occasionally small amounts of L-sugars as well. Xylose is always the sugar monomer present in the largest amount, but mannuronic acid and galacturonic acid also tend to be present." [GOC:tair_curators] subset: gosubset_prok synonym: "hemicellulose metabolism" EXACT [] is_a: GO:0010383 ! cell wall polysaccharide metabolic process [Term] id: GO:0010411 name: xyloglucan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xyloglucan, the cross-linking glycan composed of (1->4)-beta-D-glucan backbone substituted at regular intervals with beta-D-xylosyl-(1->6) residues, which is present in the primary cell wall of most higher plants." [GOC:tair_curators] synonym: "xyloglucan metabolism" EXACT [] is_a: GO:0006073 ! cellular glucan metabolic process is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010410 ! hemicellulose metabolic process [Term] id: GO:0010412 name: mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving mannan, a group of polysaccharides containing a backbone composed of a polymer of D-mannose units." [GOC:tair_curators] subset: gosubset_prok synonym: "mannan metabolism" EXACT [] is_a: GO:0010382 ! cellular cell wall macromolecule metabolic process is_a: GO:0010410 ! hemicellulose metabolic process is_a: GO:0044264 ! cellular polysaccharide metabolic process [Term] id: GO:0010413 name: glucuronoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid side units." [GOC:tair_curators] synonym: "glucuronoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010414 name: glucuronoarabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-(1->4)-linked D-xylose backbone decorated with glucuronic acid and arabinose side units." [GOC:tair_curators] synonym: "glucuronoarabinoxylan metabolism" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0010416 ! arabinoxylan metabolic process [Term] id: GO:0010415 name: unsubstituted mannan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the mannan backbone, the unsubstituted polymer of D-mannose units." [GOC:tair_curators] synonym: "unsubstituted mannan metabolism" EXACT [] is_a: GO:0010412 ! mannan metabolic process [Term] id: GO:0010416 name: arabinoxylan metabolic process namespace: biological_process def: "The chemical reactions and pathways involving xylan, a polymer containing a beta-1,4-linked D-xylose backbone decorated with arabinose side units." [GOC:tair_curators] synonym: "arabinoxylan metabolism" EXACT [] is_a: GO:0045491 ! xylan metabolic process [Term] id: GO:0010417 name: glucuronoxylan biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of glucuronoxylan, a polymer containing a beta-1,4-linked D-xylose backbone substituted with glucuronic acid residues." [GOC:tair_curators] synonym: "glucuronoxylan anabolism" EXACT [] synonym: "glucuronoxylan biosynthesis" EXACT [] synonym: "glucuronoxylan formation" EXACT [] synonym: "glucuronoxylan synthesis" EXACT [] is_a: GO:0010413 ! glucuronoxylan metabolic process is_a: GO:0045492 ! xylan biosynthetic process [Term] id: GO:0010418 name: rhamnogalacturonan II backbone metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the backbone structure of pectic rhamnogalacturonan II. The back bone contains at least 8 1,4-linked alpha-D-GalpA residues." [GOC:tair_curators] synonym: "rhamnogalacturonan II backbone metabolism" EXACT [] is_a: GO:0010394 ! homogalacturonan metabolic process is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010419 name: rhamnogalacturonan II side chain metabolic process namespace: biological_process def: "The chemical reactions and pathways involving the side chains of pectic rhamnogalacturonan II. A number of structurally distinct di- and oligosaccharides can be attached to the C-3 and C-2 of the backbone, respectively." [GOC:tair_curators] synonym: "rhamnogalacturonan II side chain metabolism" EXACT [] is_a: GO:0010396 ! rhamnogalacturonan II metabolic process [Term] id: GO:0010420 name: polyprenyldihydroxybenzoate methyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosyl-L-methionine + 3-polyprenyl-4,5-dihydroxybenzoate = S-adenosyl-L-homocysteine + 3-polyprenyl-4-hydroxy-5-methoxybenzoate (or 3-polyprenyl-5-hydroxy-4-methoxybenzoate)." [PMID:9628017] is_a: GO:0008757 ! S-adenosylmethionine-dependent methyltransferase activity [Term] id: GO:0010421 name: hydrogen peroxide-mediated programmed cell death namespace: biological_process def: "Programmed cell death induced by hydrogen peroxide. Programmed cell death is the cell death resulting from activation of endogenous cellular processes." [PMID:16036580] is_a: GO:0012501 ! programmed cell death [Term] id: GO:0010422 name: regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0090030 ! regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0016132 ! brassinosteroid biosynthetic process relationship: regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010423 name: negative regulation of brassinosteroid biosynthetic process namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of brassinosteroids." [PMID:16857903] is_a: GO:0010422 ! regulation of brassinosteroid biosynthetic process is_a: GO:0090032 ! negative regulation of steroid hormone biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process relationship: negatively_regulates GO:0016132 ! brassinosteroid biosynthetic process [Term] id: GO:0010424 name: DNA methylation on cytosine within a CG sequence namespace: biological_process def: "The covalent transfer of a methyl group to C-5 or N-4 of a cytosine located within a CG sequence in a DNA molecule." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010425 name: DNA methylation on cytosine within a CNG sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within a CNG sequence in a DNA molecule. N stands for any nucleotide." [GOC:dph, GOC:tb, PMID:17239600] synonym: "cytosine methylation within a CNG sequence" EXACT [GOC:dph, GOC:tb] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010426 name: DNA methylation on cytosine within a CHH sequence namespace: biological_process def: "The covalent transfer of a methyl group, to C-5 or N-4, of a cytosine located within an asymmetric CHH sequence in a DNA molecule. H stands for an adenine, cytosine, or thymine nucleotide." [GOC:dph, GOC:mah, GOC:tb, PMID:15861207, PMID:17239600] synonym: "cytosine methylation within a CHH sequence" EXACT [GOC:mah] synonym: "cytosine methylation within a CNN sequence" EXACT [GOC:dph, GOC:tb] synonym: "DNA methylation on cytosine within a CNN sequence" EXACT [GOC:mah] is_a: GO:0032776 ! DNA methylation on cytosine [Term] id: GO:0010427 name: abscisic acid binding namespace: molecular_function def: "Interacting selectively and non-covalently with abscisic acid, plant hormones that regulate aspects of plant growth." [PMID:17347412] synonym: "ABA binding" RELATED [] synonym: "abscisate binding" RELATED [] is_a: GO:0019840 ! isoprenoid binding is_a: GO:0033293 ! monocarboxylic acid binding is_a: GO:0042562 ! hormone binding [Term] id: GO:0010428 name: methyl-CpNpG binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/guanine trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010429 name: methyl-CpNpN binding namespace: molecular_function def: "Interacting selectively and non-covalently with a methylated cytosine/unspecified/unspecified trinucleotide." [PMID:17239600] is_a: GO:0000166 ! nucleotide binding [Term] id: GO:0010430 name: fatty acid omega-oxidation namespace: biological_process def: "A fatty acid oxidation process in which the methyl group at the end of the fatty acid molecule (the omega carbon) is first oxidized to a hydroxyl group, then to an oxo group, and finally to a carboxyl group. The long chain dicarboxylates derived from omega-oxidation then enter the beta-oxidation pathway for further degradation." [MetaCyc:PWY-2724, PMID:16404574] xref: MetaCyc:PWY-2724 is_a: GO:0019395 ! fatty acid oxidation [Term] id: GO:0010431 name: seed maturation namespace: biological_process def: "A process in seed development that occurs after embryogenesis by which a quiescent state is established in a seed. Seed maturation is characterized by storage compound accumulation, acquisition of desiccation tolerance, growth arrest and the entry into a dormancy period of variable length that is broken upon germination." [PMID:16096971] is_a: GO:0048609 ! reproductive process in a multicellular organism relationship: part_of GO:0048316 ! seed development [Term] id: GO:0010432 name: bract development namespace: biological_process def: "The process whose specific outcome is the progression of the bract over time, from its formation to the mature structure. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048827 ! phyllome development [Term] id: GO:0010433 name: bract morphogenesis namespace: biological_process def: "The process by which the anatomical structure of bract are generated and organized. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence. Morphogenesis pertains to the creation of form." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0009887 ! organ morphogenesis relationship: part_of GO:0010432 ! bract development [Term] id: GO:0010434 name: bract formation namespace: biological_process def: "The process that gives rise to a bract. This process pertains to the initial formation of a structure from unspecified parts. A bract is a leaf, usually different in form from the foliage leaves, subtending a flower or inflorescence." [GOC:tb, PMID:16554366, PO:0009055] is_a: GO:0048646 ! anatomical structure formation involved in morphogenesis relationship: part_of GO:0010433 ! bract morphogenesis [Term] id: GO:0010435 name: 3-oxo-2-(2'-pentenyl)cyclopentane-1-octanoic acid (OPC-8:0) CoA ligase activity namespace: molecular_function def: "Catalysis of the reaction: ATP + 3-oxo-2-(2'-pentenyl)-cyclopentane-1-octanoic acid (OPC-8:0) + CoA = AMP + diphosphate + 3-oxo-2-(2'-pentenyl)- cyclopentane-1-octanoyl-CoA." [PMID:16963437] synonym: "OPC-8:0 CoA ligase activity" RELATED [] is_a: GO:0016405 ! CoA-ligase activity [Term] id: GO:0010436 name: carotenoid dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids." [PMID:16459333] synonym: "carotenoid-cleaving dioxygenase" RELATED [] is_a: GO:0016702 ! oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen [Term] id: GO:0010437 name: 9,10 (9', 10')-carotenoid-cleaving dioxygenase activity namespace: molecular_function def: "Catalysis of the oxidative cleavage of carotenoids at the (9, 10) and/or (9', 10') double bond." [PMID:16459333] is_a: GO:0010436 ! carotenoid dioxygenase activity [Term] id: GO:0010438 name: cellular response to sulfur starvation namespace: biological_process def: "A change in the state or activity of a cell (in terms of enzyme production, gene expression, etc.) as a result of deprivation of sulfur." [PMID:17420480] is_a: GO:0009267 ! cellular response to starvation [Term] id: GO:0010439 name: regulation of glucosinolate biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucosinolates, substituted thioglucosides found in rapeseed products and related cruciferae." [PMID:17420480] is_a: GO:0010675 ! regulation of cellular carbohydrate metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0042762 ! regulation of sulfur metabolic process is_a: GO:0043255 ! regulation of carbohydrate biosynthetic process is_a: GO:0043455 ! regulation of secondary metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0019761 ! glucosinolate biosynthetic process relationship: regulates GO:0019761 ! glucosinolate biosynthetic process [Term] id: GO:0010440 name: stomatal lineage progression namespace: biological_process def: "The process by which an unspecialized epidermal cell progresses through a series of divisions that culminate in the production of a stomatal complex." [GOC:expert_db, GOC:tb] is_a: GO:0048869 ! cellular developmental process relationship: part_of GO:0010374 ! stomatal complex development [Term] id: GO:0010441 name: guard cell development namespace: biological_process def: "The process whose specific outcome is the progression of the guard cell over time, from its formation to the mature structure." [GOC:tb] is_a: GO:0048468 ! cell development relationship: part_of GO:0010052 ! guard cell differentiation [Term] id: GO:0010442 name: guard cell morphogenesis namespace: biological_process def: "Generation and organization of the polarized cell that is capable of turgor driven movement." [GOC:expert_db, GOC:tb] synonym: "guard cell morphogenesis during differentiation" EXACT [] is_a: GO:0000904 ! cell morphogenesis involved in differentiation is_a: GO:0009886 ! post-embryonic morphogenesis relationship: part_of GO:0010441 ! guard cell development [Term] id: GO:0010443 name: meristemoid mother cell division namespace: biological_process def: "The asymmetric cell division by which a meristemoid mother cells (MMC) give rise to a meristemoid and another cell. The other cell may itself become a MMC or may generate an epidermal cell. Any cell that undergoes this type of division is a MMC." [GOC:expert_db, GOC:tb] synonym: "meristemoid division" RELATED [] is_a: GO:0000911 ! cytokinesis by cell plate formation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010444 name: guard mother cell differentiation namespace: biological_process def: "The process by which a meristemoid acquires the specialized features of a guard mother cell." [GOC:expert_db, GOC:tb] is_a: GO:0030154 ! cell differentiation relationship: part_of GO:0010440 ! stomatal lineage progression [Term] id: GO:0010445 name: nuclear dicing body namespace: cellular_component def: "A small round nuclear body, measuring 0.2-0.8 microns in diameter that is diffusely distributed throughout the nucleoplasm. Several proteins known to be involved in miRNA processing have been localized to these structures. D-bodies are thought to be involved in primary-miRNA processing and/or storage/assembly of miRNA processing complexes." [PMID:17442570] synonym: "D body" EXACT [] is_a: GO:0016604 ! nuclear body [Term] id: GO:0010446 name: response to alkalinity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH > 7." [GOC:tb] synonym: "response to alkaline pH" EXACT [] synonym: "response to basic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010447 name: response to acidity namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7." [GOC:tb] synonym: "response to acidic pH" EXACT [] is_a: GO:0009268 ! response to pH [Term] id: GO:0010448 name: vegetative meristem growth namespace: biological_process def: "The increase in size or mass of a vegetative meristem, a population of undifferentiated cells in a plant shoot which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into lateral organ primordia." [GOC:tb, ISBN:0849397928] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048367 ! shoot development [Term] id: GO:0010449 name: root meristem growth namespace: biological_process def: "The increase in size or mass of a root meristem, a population of undifferentiated cells in a plant root which maintains a continuous balance between the production of stem cells and the incorporation of their derivatives into the growth of the root." [GOC:tb] is_a: GO:0035266 ! meristem growth relationship: part_of GO:0048364 ! root development [Term] id: GO:0010450 name: inflorescence meristem growth namespace: biological_process def: "The increase in size or mass of an inflorescence meristem, a population of undifferentiated cells in a plant shoot which produces small leaves and then floral meristems, which will give rise to flowers." [GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0035266 ! meristem growth relationship: part_of GO:0010229 ! inflorescence development [Term] id: GO:0010451 name: floral meristem growth namespace: biological_process def: "The increase in size or mass of a floral meristem, a population of undifferentiated cells in a plant that gives rise to a flower." [GOC:tb] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0035266 ! meristem growth relationship: part_of GO:0009908 ! flower development [Term] id: GO:0010452 name: histone H3-K36 methylation namespace: biological_process def: "The modification of histone H3 by addition of a methyl group to lysine at position 36 of the histone." [GOC:tb] synonym: "histone H3 K36 methylation" EXACT [GOC:tb] synonym: "histone H3K36me" EXACT [GOC:tb] synonym: "histone lysine H3 K36 methylation" EXACT [GOC:tb] is_a: GO:0034968 ! histone lysine methylation [Term] id: GO:0010453 name: regulation of cell fate commitment namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0045595 ! regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0045165 ! cell fate commitment relationship: regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010454 name: negative regulation of cell fate commitment namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045596 ! negative regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0045165 ! cell fate commitment relationship: negatively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010455 name: positive regulation of cell fate commitment namespace: biological_process def: "Any process that activates, maintains or increases the frequency or rate of cell fate commitment. Cell fate commitment is the commitment of cells to specific cell fates and their capacity to differentiate into particular kinds of cells. Positional information is established through protein signals that emanate from a localized source within a cell (the initial one-cell zygote) or within a developmental field." [GOC:dph, GOC:tb] is_a: GO:0010453 ! regulation of cell fate commitment is_a: GO:0045597 ! positive regulation of cell differentiation intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0045165 ! cell fate commitment relationship: positively_regulates GO:0045165 ! cell fate commitment [Term] id: GO:0010456 name: cell proliferation in dorsal spinal cord namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of the dorsal spinal cord cell population." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0010457 name: centriole-centriole cohesion namespace: biological_process def: "The process by which the two centrioles within a centrosome remain tightly paired." [GOC:dph, GOC:tb] is_a: GO:0051297 ! centrosome organization [Term] id: GO:0010458 name: exit from mitosis namespace: biological_process def: "The cell cycle process where a cell leaves M phase. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place." [GOC:dph, GOC:tb] is_a: GO:0022402 ! cell cycle process relationship: part_of GO:0000087 ! M phase of mitotic cell cycle [Term] id: GO:0010459 name: negative regulation of heart rate namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045822 ! negative regulation of heart contraction [Term] id: GO:0010460 name: positive regulation of heart rate namespace: biological_process def: "Any process that activates or increases the frequency or rate of heart contraction." [GOC:dph, GOC:tb] is_a: GO:0002027 ! regulation of heart rate is_a: GO:0045823 ! positive regulation of heart contraction [Term] id: GO:0010461 name: light-activated ion channel activity namespace: molecular_function def: "Catalysis of the transmembrane transfer of an ion by a channel that opens in response to a light stimulus." [GOC:dph, GOC:tb] is_a: GO:0005216 ! ion channel activity [Term] id: GO:0010462 name: regulation of light-activated voltage-gated calcium channel activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of light-activated voltage-gated calcium channel activity." [GOC:dph, GOC:tb] is_a: GO:0016061 ! regulation of light-activated channel activity is_a: GO:0050848 ! regulation of calcium-mediated signaling is_a: GO:0051925 ! regulation of calcium ion transport via voltage-gated calcium channel activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity relationship: regulates GO:0008086 ! light-activated voltage-gated calcium channel activity [Term] id: GO:0010463 name: mesenchymal cell proliferation namespace: biological_process def: "The multiplication or reproduction of cells, resulting in the expansion of a mesenchymal cell population. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0008283 ! cell proliferation [Term] id: GO:0010464 name: regulation of mesenchymal cell proliferation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of mesenchymal cell proliferation. A mesenchymal cell is a cell that normally gives rise to other cells that are organized as three-dimensional masses, rather than sheets." [GOC:dph, GOC:tb] is_a: GO:0042127 ! regulation of cell proliferation intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010463 ! mesenchymal cell proliferation relationship: regulates GO:0010463 ! mesenchymal cell proliferation [Term] id: GO:0010465 name: nerve growth factor receptor activity namespace: molecular_function def: "Combining with nerve growth factor, to block apoptosis in neurons and promote nerve growth, or to initiate a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0005030 ! neurotrophin receptor activity relationship: part_of GO:0048011 ! nerve growth factor receptor signaling pathway [Term] id: GO:0010466 name: negative regulation of peptidase activity namespace: biological_process def: "Any process that stops or reduces the rate of peptidase activity, the hydrolysis of peptide bonds within proteins." [GOC:dph, GOC:tb] is_a: GO:0051346 ! negative regulation of hydrolase activity is_a: GO:0052547 ! regulation of peptidase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0008233 ! peptidase activity relationship: negatively_regulates GO:0008233 ! peptidase activity [Term] id: GO:0010467 name: gene expression namespace: biological_process def: "The process by which a gene's sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: gosubset_prok xref: Reactome:562818 "Gene Expression" xref: Reactome:588434 "Gene Expression" xref: Reactome:609176 "Gene Expression" xref: Reactome:633870 "Gene Expression" xref: Reactome:645452 "Gene Expression" xref: Reactome:655815 "Gene Expression" xref: Reactome:661043 "Gene Expression" xref: Reactome:666799 "Gene Expression" xref: Reactome:672910 "Gene Expression" xref: Reactome:678624 "Gene Expression" xref: Reactome:683564 "Gene Expression" xref: Reactome:689783 "Gene Expression" xref: Reactome:701505 "Gene Expression" xref: Reactome:716077 "Gene Expression" xref: Reactome:720722 "Gene Expression" xref: Reactome:728041 "Gene Expression" xref: Reactome:730950 "Gene Expression" xref: Reactome:733043 "Gene Expression" xref: Reactome:733888 "Gene Expression" xref: Reactome:735606 "Gene Expression" xref: Reactome:736558 "Gene Expression" xref: Reactome:738518 "Gene Expression" xref: Reactome:74160 "Gene Expression" xref: Wikipedia:Gene_expression is_a: GO:0043170 ! macromolecule metabolic process [Term] id: GO:0010468 name: regulation of gene expression namespace: biological_process def: "Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form." [GOC:dph, GOC:tb] subset: gosubset_prok synonym: "regulation of gene product expression" RELATED [GOC:curators] synonym: "regulation of protein expression" NARROW [GOC:curators] xref: Wikipedia:Regulation_of_gene_expression is_a: GO:0060255 ! regulation of macromolecule metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010467 ! gene expression relationship: regulates GO:0010467 ! gene expression [Term] id: GO:0010469 name: regulation of receptor activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of receptor activity. Receptor activity is when a molecule combines with an extracellular or intracellular messenger to initiate a change in cell activity." [GOC:dph, GOC:tb] is_a: GO:0009966 ! regulation of signal transduction is_a: GO:0065009 ! regulation of molecular function intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004872 ! receptor activity relationship: regulates GO:0004872 ! receptor activity [Term] id: GO:0010470 name: regulation of gastrulation namespace: biological_process def: "Any process that modulates the rate or extent of gastrulation. Gastrulation is the complex and coordinated series of cellular movements that occurs at the end of cleavage during embryonic development of most animals." [GOC:dph, GOC:tb] is_a: GO:0022603 ! regulation of anatomical structure morphogenesis is_a: GO:0045995 ! regulation of embryonic development intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007369 ! gastrulation relationship: regulates GO:0007369 ! gastrulation [Term] id: GO:0010471 name: GDP-galactose:mannose-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + mannose-1-phosphate = galactose-1-phosphate + GDP-mannose." [PMID:17485667] is_a: GO:0008905 ! mannose-phosphate guanylyltransferase activity [Term] id: GO:0010472 name: GDP-galactose:glucose-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + glucose-1-phosphate = galactose-1-phosphate + GDP-glucose." [PMID:17485667] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010473 name: GDP-galactose:myoinositol-1-phosphate guanyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: GDP-galactose-1-phosphate + myoinositol-1-phosphate = galactose-1-phosphate + GDP-myoinositol." [PMID:17485667] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010474 name: glucose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + D-glucose 1-phosphate = phosphate + GDP-glucose." [PMID:17462988] synonym: "GDP:Glucose-1- phosphate guanyltransferase activity " EXACT [] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010475 name: galactose-1-phosphate guanylyltransferase (GDP) activity namespace: molecular_function def: "Catalysis of the reaction: GDP + L-galactose 1-phosphate = phosphate + GDP-galactose." [PMID:17462988] is_a: GO:0070568 ! guanylyltransferase activity [Term] id: GO:0010476 name: gibberellin mediated signaling pathway namespace: biological_process def: "The series of molecular signals generated as a consequence of gibberellin stimulus." [PMID:17521411] synonym: "gibberellin-mediated signalling" EXACT [GOC:mah] is_a: GO:0009755 ! hormone-mediated signaling pathway [Term] id: GO:0010477 name: response to sulfur dioxide namespace: biological_process def: "A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sulfur dioxide (SO2) stimulus." [PMID:17425719] is_a: GO:0010035 ! response to inorganic substance [Term] id: GO:0010478 name: chlororespiration namespace: biological_process def: "A respiratory electron flow (from NAD(P)H to plastoquinone (PQ) and O2) involving both a nonphotochemical reduction and re-oxidation of PQ pool." [GOC:mtg_electron_transport, GOC:tb, PMID:17573537] is_a: GO:0022904 ! respiratory electron transport chain [Term] id: GO:0010479 name: stele development namespace: biological_process def: "The process whose specific outcome is the progression of the stele over time, from its formation to the mature structure. The stele is the central column of primary vascular tissue in the root and any tissue that it surrounds." [GOC:tb] is_a: GO:0009888 ! tissue development relationship: part_of GO:0048364 ! root development [Term] id: GO:0010480 name: microsporocyte differentiation namespace: biological_process def: "The process aimed at the progression of a microsporocyte cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A microsporocyte is a diploid (2n) cell that undergoes meiosis and forms four haploid (1n) microspores; also called microspore mother cell and, in seed plants, pollen mother cell." [CL:0000248 "Cell type ontology", PMID:16751349] synonym: "pollen mother cell differentiation" RELATED [] is_a: GO:0003006 ! reproductive developmental process is_a: GO:0030154 ! cell differentiation is_a: GO:0048610 ! reproductive cellular process relationship: part_of GO:0048653 ! anther development [Term] id: GO:0010481 name: epidermal cell division namespace: biological_process def: "Any process resulting in the physical partitioning and separation of an epidermal cell, any of the cells making up the epidermis, into daughter cells." [PMID:17450124] synonym: "hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051301 ! cell division [Term] id: GO:0010482 name: regulation of epidermal cell division namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the physical partitioning and separation of an epidermal cell into daughter cells. An epidermal cell is any of the cells that make up the epidermis." [PMID:17450124] synonym: "regulation of hypodermal cell division" RELATED [GOC:kmv, GOC:rk] is_a: GO:0051302 ! regulation of cell division intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0010481 ! epidermal cell division relationship: regulates GO:0010481 ! epidermal cell division [Term] id: GO:0010483 name: pollen tube reception namespace: biological_process def: "Interaction between the pollen tube, part of the male gametophyte, and the ovule, part of the female gametophyte, that results in the arrest of pollen tube growth, rupture of the pollen tube and the release of the sperm cells." [GOC:tb, PMID:17673660] is_a: GO:0051703 ! intraspecies interaction between organisms relationship: part_of GO:0009856 ! pollination [Term] id: GO:0010484 name: H3 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H3." [PMID:17877703] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010485 name: H4 histone acetyltransferase activity namespace: molecular_function def: "Catalysis of the addition of an acetyl group to a histone, specific for histones H4." [PMID:17877703] is_a: GO:0004402 ! histone acetyltransferase activity [Term] id: GO:0010486 name: manganese:hydrogen antiporter activity namespace: molecular_function def: "Catalysis of the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Mn2+(in) + H+(out) = Mn2+(out) + H+(in)." [PMID:17559518] synonym: "manganese:proton antiporter activity" EXACT [GOC:mah] is_a: GO:0051139 ! metal ion:hydrogen antiporter activity [Term] id: GO:0010487 name: thermospermine synthase activity namespace: molecular_function def: "Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + thermospermine." [PMID:17560575] is_a: GO:0016765 ! transferase activity, transferring alkyl or aryl (other than methyl) groups [Term] id: GO:0010488 name: UDP-galactose:N-glycan beta-1,3-galactosyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-galactose + N-glycan = galactose-beta-1,3-N-glycan + UDP." [PMID:17630273] is_a: GO:0035250 ! UDP-galactosyltransferase activity [Term] id: GO:0010489 name: UDP-4-keto-6-deoxy-glucose-3,5-epimerase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-6-deoxyglucose -> UDP-4-keto-rhamnose." [GOC:tair_curators, PMID:17190829] is_a: GO:0016857 ! racemase and epimerase activity, acting on carbohydrates and derivatives [Term] id: GO:0010490 name: UDP-4-keto-rhamnose-4-keto-reductase activity namespace: molecular_function def: "Catalysis of the reaction: UDP-4-keto-rhamnose + NADPH -> UDP-rhamnose + NADP+." [GOC:tair_curators, PMID:17190829] is_a: GO:0016616 ! oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [Term] id: GO:0010491 name: UTP:arabinose-1-phosphate uridylyltransferase activity namespace: molecular_function def: "Catalysis of the reaction: alpha-L-arabinose 1-phosphate + UTP = UDP-L-arabinose + diphosphate." [PMID:17341835] is_a: GO:0051748 ! UTP-monosaccharide-1-phosphate uridylyltransferase activity [Term] id: GO:0010492 name: maintenance of shoot apical meristem identity namespace: biological_process def: "The process by which an organism retains a population of shoot apical meristem cells, preventing the commitment of all stem cell progeny to a differentiated cell fate." [GOC:dph, GOC:tb, PMID:17461786] is_a: GO:0010074 ! maintenance of meristem identity [Term] id: GO:0010493 name: Lewis a epitope biosynthetic process namespace: biological_process def: "The chemical reactions and pathways resulting in the formation of a Lewis a epitope, a trisaccharide (Fuc-alpha-1->4(Gal-beta-1->3)GlcNAc) characteristic of plant protein N-linked oligosaccharides." [PMID:17630273] synonym: "LE A biosynthetic process" RELATED [] is_a: GO:0033692 ! cellular polysaccharide biosynthetic process [Term] id: GO:0010494 name: stress granule namespace: cellular_component def: "A dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress." [PMID:17601829] xref: Wikipedia:Stress_granule is_a: GO:0030529 ! ribonucleoprotein complex is_a: GO:0044444 ! cytoplasmic part [Term] id: GO:0010495 name: long-distance posttranscriptional gene silencing namespace: biological_process def: "A posttranscriptional gene silencing process in which the silencing signal originates in a tissue separate from the tissue in which the silencing takes place." [GOC:dph, GOC:tb, PMID:11590235, PMID:17785412] synonym: "long-distance propagation of posttranscriptional gene silencing" EXACT [GOC:dph, GOC:tb] is_a: GO:0016441 ! posttranscriptional gene silencing [Term] id: GO:0010496 name: intercellular transport namespace: biological_process def: "The movement of substances between cells in a multicellular organism." [GOC:dhl] is_a: GO:0006810 ! transport is_a: GO:0032501 ! multicellular organismal process [Term] id: GO:0010497 name: plasmodesmata-mediated intercellular transport namespace: biological_process def: "The movement of substances between cells via plasmodesmata. Plasmodesmata is a fine cytoplasmic channel, found in all higher plants, that connects the cytoplasm of one cell to that of an adjacent cell." [PMID:17601829] synonym: "plasmodesma-mediated cell-to-cell transport" EXACT [] synonym: "plasmodesma-mediated intercellular transport" EXACT [] synonym: "plasmodesmata-mediated cell-to-cell transport" EXACT [] is_a: GO:0010496 ! intercellular transport [Term] id: GO:0010498 name: proteasomal protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome." [GOC:tb] synonym: "proteasome-mediated protein catabolic process" EXACT [] synonym: "proteasome-mediated protein catabolism" EXACT [] is_a: GO:0051603 ! proteolysis involved in cellular protein catabolic process [Term] id: GO:0010499 name: proteasomal ubiquitin-independent protein catabolic process namespace: biological_process def: "The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds that is mediated by the proteasome but do not involve ubiquitin." [GOC:tb] is_a: GO:0010498 ! proteasomal protein catabolic process [Term] id: GO:0010500 name: transmitting tissue development namespace: biological_process def: "The process whose specific outcome is the progression of the transmitting tract over time, from its formation to the mature structure. The transmitting tissue is the tissue in the style of a carpel through which the pollen tube grows; it connects the stigma and the inside of ovary." [PMID:17855426] is_a: GO:0048467 ! gynoecium development [Term] id: GO:0010501 name: RNA secondary structure unwinding namespace: biological_process def: "The process by which a secondary structure of RNA are broken or 'melted'." [PMID:17169986] synonym: "RNA duplex unwinding" EXACT [GOC:ecd] is_a: GO:0016070 ! RNA metabolic process [Term] id: GO:0010502 name: plastoglobuli namespace: cellular_component def: "Lipid bodies localized within the chloroplast stroma." [PMID:17259290] is_a: GO:0044434 ! chloroplast part relationship: part_of GO:0009570 ! chloroplast stroma [Term] id: GO:0010503 name: negative regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation is_a: GO:0010516 ! negative regulation of cellular response to nitrogen starvation is_a: GO:0071157 ! negative regulation of cell cycle arrest intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation relationship: negatively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010504 name: regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that modulates the frequency, rate or extent of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010646 ! regulation of cell communication is_a: GO:0032107 ! regulation of response to nutrient levels is_a: GO:0071156 ! regulation of cell cycle arrest is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation relationship: regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010505 name: positive regulation of cell cycle arrest in response to nitrogen starvation namespace: biological_process def: "Any process that increases the frequency or rate of cell cycle arrest in response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010504 ! regulation of cell cycle arrest in response to nitrogen starvation is_a: GO:0010647 ! positive regulation of cell communication is_a: GO:0032109 ! positive regulation of response to nutrient levels is_a: GO:0071158 ! positive regulation of cell cycle arrest intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation relationship: positively_regulates GO:0030996 ! cell cycle arrest in response to nitrogen starvation [Term] id: GO:0010506 name: regulation of autophagy namespace: biological_process def: "Any process that modulates the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0031329 ! regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006914 ! autophagy relationship: regulates GO:0006914 ! autophagy [Term] id: GO:0010507 name: negative regulation of autophagy namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031330 ! negative regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006914 ! autophagy relationship: negatively_regulates GO:0006914 ! autophagy [Term] id: GO:0010508 name: positive regulation of autophagy namespace: biological_process def: "Any process that activates, maintains or increases the rate of autophagy. Autophagy is the process by which cells digest parts of their own cytoplasm." [GOC:dph, GOC:tb] is_a: GO:0010506 ! regulation of autophagy is_a: GO:0031331 ! positive regulation of cellular catabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006914 ! autophagy relationship: positively_regulates GO:0006914 ! autophagy [Term] id: GO:0010509 name: polyamine homeostasis namespace: biological_process def: "Any biological process involved in the maintenance of an internal steady-state of a polyamine." [GOC:dph, GOC:rph, GOC:tb, PMID:11161802, PMID:9761731] is_a: GO:0048878 ! chemical homeostasis [Term] id: GO:0010510 name: regulation of acetyl-CoA biosynthetic process from pyruvate namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of acetyl-CoA from pyruvate." [GOC:dph, GOC:tb] xref: Reactome:204174 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:563324 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:588939 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:609662 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:634354 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:645819 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:656140 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:673216 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:678900 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:683837 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:690080 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:701832 "Regulation of pyruvate dehydrogenase (PDH) complex" xref: Reactome:716407 "Regulation of pyruvate dehydrogenase (PDH) complex" is_a: GO:0010565 ! regulation of cellular ketone metabolic process is_a: GO:0031326 ! regulation of cellular biosynthetic process is_a: GO:0051196 ! regulation of coenzyme metabolic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate relationship: regulates GO:0006086 ! acetyl-CoA biosynthetic process from pyruvate [Term] id: GO:0010511 name: regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0071071 ! regulation of phospholipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010512 name: negative regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071072 ! negative regulation of phospholipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: negatively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010513 name: positive regulation of phosphatidylinositol biosynthetic process namespace: biological_process def: "Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of phosphatidylinositol." [GOC:dph, GOC:tb, GOC:vw] is_a: GO:0010511 ! regulation of phosphatidylinositol biosynthetic process is_a: GO:0071073 ! positive regulation of phospholipid biosynthetic process intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process relationship: positively_regulates GO:0006661 ! phosphatidylinositol biosynthetic process [Term] id: GO:0010514 name: induction of conjugation with cellular fusion namespace: biological_process def: "The process by which a cell initiates conjugation with cellular fusion. Conjugation with cellular fusion is the process that results in the union of cellular and genetic information from compatible mating types." [GOC:dph, GOC:tb] is_a: GO:0031139 ! positive regulation of conjugation with cellular fusion [Term] id: GO:0010515 name: negative regulation of induction of conjugation with cellular fusion namespace: biological_process def: "The process by which a cell decreases the rate or frequency of the initiation of conjugation with cellular fusion." [GOC:dph, GOC:tb] is_a: GO:0031138 ! negative regulation of conjugation with cellular fusion intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion relationship: negatively_regulates GO:0010514 ! induction of conjugation with cellular fusion [Term] id: GO:0010516 name: negative regulation of cellular response to nitrogen starvation namespace: biological_process def: "Any process that stops, prevents or reduces the frequency, rate or extent of a cellular response to nitrogen starvation." [GOC:dph, GOC:tb] is_a: GO:0010648 ! negative regulation of cell communication is_a: GO:0032108 ! negative regulation of response to nutrient levels is_a: GO:0080135 ! regulation of cellular response to stress intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation relationship: negatively_regulates GO:0006995 ! cellular response to nitrogen starvation [Term] id: GO:0010517 name: regulation of phospholipase activity namespace: biological_process def: "Any process that modulates the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0060191 ! regulation of lipase activity intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0004620 ! phospholipase activity relationship: regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010518 name: positive regulation of phospholipase activity namespace: biological_process def: "Any process that increases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060193 ! positive regulation of lipase activity intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0004620 ! phospholipase activity relationship: positively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010519 name: negative regulation of phospholipase activity namespace: biological_process def: "Any process that decreases the frequency, rate or extent of phospholipase activity, the hydrolysis of a phospholipid." [GOC:BHF, GOC:dph, GOC:tb] is_a: GO:0010517 ! regulation of phospholipase activity is_a: GO:0060192 ! negative regulation of lipase activity intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0004620 ! phospholipase activity relationship: negatively_regulates GO:0004620 ! phospholipase activity [Term] id: GO:0010520 name: regulation of reciprocal meiotic recombination namespace: biological_process def: "Any process that modulates the frequency, rate or extent of recombination during meiosis. Reciprocal meiotic recombination is the cell cycle process whereby double strand breaks are formed and repaired through a double Holliday junction intermediate." [GOC:dph, GOC:tb] is_a: GO:0000018 ! regulation of DNA recombination is_a: GO:0060631 ! regulation of meiosis I intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0007131 ! reciprocal meiotic recombination relationship: regulates GO:0007131 ! reciprocal meiotic recombination [Term] id: GO:0010521 name: telomerase inhibitor activity namespace: molecular_function def: "Stops, prevents or reduces the activity of a telomerase. Telomerase catalyzes the reaction: deoxynucleoside triphosphate + DNA(n) = diphosphate + DNA(n+1). Catalyzes extension of the 3'- end of a DNA strand by one deoxynucleotide at a time using an internal RNA template that encodes the telomeric repeat sequence." [GOC:dph, GOC:krc, GOC:tb] is_a: GO:0004857 ! enzyme inhibitor activity relationship: negatively_regulates GO:0003720 ! telomerase activity [Term] id: GO:0010522 name: regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that modulates the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0032844 ! regulation of homeostatic process is_a: GO:0050794 ! regulation of cellular process is_a: GO:0051924 ! regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0060402 ! calcium ion transport into cytosol relationship: regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010523 name: negative regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that decreases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0032845 ! negative regulation of homeostatic process is_a: GO:0048523 ! negative regulation of cellular process is_a: GO:0051926 ! negative regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0060402 ! calcium ion transport into cytosol relationship: negatively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010524 name: positive regulation of calcium ion transport into cytosol namespace: biological_process def: "Any process that increases the rate of the directed movement of calcium ions into the cytosol of a cell. The cytosol is that part of the cytoplasm that does not contain membranous or particulate subcellular components." [GOC:dph, GOC:tb] is_a: GO:0010522 ! regulation of calcium ion transport into cytosol is_a: GO:0032846 ! positive regulation of homeostatic process is_a: GO:0048522 ! positive regulation of cellular process is_a: GO:0051928 ! positive regulation of calcium ion transport intersection_of: GO:0065007 ! biological regulation intersection_of: positively_regulates GO:0060402 ! calcium ion transport into cytosol relationship: positively_regulates GO:0060402 ! calcium ion transport into cytosol [Term] id: GO:0010525 name: regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that modulates the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010528 ! regulation of transposition intersection_of: GO:0065007 ! biological regulation intersection_of: regulates GO:0032197 ! transposition, RNA-mediated relationship: regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010526 name: negative regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that decreases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010529 ! negative regulation of transposition intersection_of: GO:0065007 ! biological regulation intersection_of: negatively_regulates GO:0032197 ! transposition, RNA-mediated relationship: negatively_regulates GO:0032197 ! transposition, RNA-mediated [Term] id: GO:0010527 name: positive regulation of transposition, RNA-mediated namespace: biological_process def: "Any process that increases the frequency, rate or extent of RNA-mediated transposition. RNA-mediated transposition is a type of transpositional recombination which occurs via an RNA intermediate." [GOC:dph, GOC:tb] is_a: GO:0010525 ! regulation of transposition, RNA-mediated is_a: GO:0010530 ! positive regulation of transp