Topaz is a pipeline for particle picking in cryo-electron micrographs using neural networks and positive-unlabeled learning.
Bepler, T., Morin, A., Rapp, M., Brasch, J., Shapiro, L., Noble, A.J.*, Berger, B.* (2019). Positive-unlabeled convolutional neural networks for particle picking in cryo-electron micrographs. Nature Methods. https://doi.org/10.1038/s41592-019-0575-8