ELT R_OBS MU SIGMA ALPHA THETA Pi_SUM OBS_SAMPLES OBS_SNV EXP_SNV PVAL_SNV_BURDEN PVAL_SAMPLE_BURDEN ABL1 313 368.69924545288086 13.94468992571952 699.0798335720351 0.4560410299807646 0.004526126559656482 1 1 1.4429702776738182 0.5930884355364767 0.5930884355364767 ABL2 300 304.34314346313477 13.45544743069569 511.6002597771823 0.5143884505217591 0.002312942562982249 0 0 0.6086768905462517 0.7278664311024927 0.7278664311024927 AKT1 167 159.5340232849121 9.786965402799641 265.71160911373073 0.5191600093500307 0.0010176671842295935 0 0 0.1403839737340707 0.5654716472521555 0.5654716472521555 AKT2 202 188.74470901489258 12.218584405252477 238.62051886578817 0.6839517161674761 0.0005926450229121807 0 0 0.09672257963600708 0.5460871967431598 0.5460871967431598 AKT3 309 339.81290435791016 18.2891235934675 345.2184074121812 0.8511465941220046 8.306784546788259e-05 0 0 0.02440794728453527 0.5120558200542874 0.5120558200542874 ALK 1559 1578.5362930297852 42.09171756080833 1406.4226363495054 0.9705036362519387 0.003681916779251713 4 4 5.025589165658095 0.6508558843932593 0.6508558843932593 ALOX12B 178 204.96492385864258 11.21280806693768 334.14142052275577 0.5304050791305701 0.0059496359736318175 0 0 1.0544558077245405 0.8255195709678321 0.8255195709678321 APC 445 401.927978515625 16.96862914118675 561.0518020027832 0.6194463816384588 0.007109366404776928 1 1 2.4707999259496796 0.810502835662995 0.810502835662995 ARHGAP26 835 878.6911163330078 23.3766911273471 1412.883632500741 0.5377597395532197 0.00021954098999162134 0 0 0.16680547342907504 0.5768137155941739 0.5768137155941739 ARID1A 294 285.3458480834961 14.374111393131882 394.0770135064913 0.6261074878948094 0.0014192110037918604 0 0 0.3501684152890369 0.64766051137859 0.64766051137859 ASXL1 275 255.09576416015625 13.945268554944823 334.620643490284 0.6591874955617335 0.024711793350737775 7 7 5.450871626156013 0.2464788654252279 0.2464788654252279 ATM 798 833.221662902832 39.009240136149835 456.2323996826041 1.5791844978482785 0.006001342020480222 2 2 4.3238176903533 0.8664082805302586 0.8664082805302586 AURKA 163 218.41205596923828 17.24497197676006 160.4088140856729 1.1773533453785066 0.004593192610180255 0 0 0.86746049887108 0.7895001988108382 0.7895001988108382 BAP1 102 100.40973663330078 8.51217634171953 139.14590564575394 0.623970186425537 0.004076797985305187 0 0 0.3539594102883804 0.6488905047314443 0.6488905047314443 BCL2L1 128 128.46842193603516 8.66503078078621 219.81258786181203 0.5053616401507507 0.0008516529314619017 0 0 0.09460573808186838 0.5451249738997762 0.5451249738997762 BCL6 70 67.64957427978516 7.33490514755249 85.06308546742792 0.6876736435118802 0.006650433365172424 0 0 0.38902136868707154 0.6608394520840224 0.6608394520840224 BIRC2 140 183.42687072753907 24.75994652067673 54.88156781252156 2.8899803563989535 0.005476001858994221 0 0 0.8685303261651978 0.7887845727762673 0.7887845727762673 BRAF 624 574.1626129150391 20.129812941613526 813.5614110567892 0.6102432888387144 0.00028156385691106535 1 1 0.1397881181759048 0.06968096173322741 0.06968096173322741 BRCA1 562 519.9906959533691 15.92314404533663 1066.4328101844687 0.4216193340726052 0.016519312658084213 5 5 7.427556931021237 0.8056340213201866 0.8056340213201866 BRCA2 555 626.8575439453125 20.095903306936453 973.0219752000178 0.5570634330566394 0.03537761054088155 14 17 19.17590178321316 0.6769627663076971 0.8812500100889772 CARD11 499 531.0818099975586 22.50934870792014 556.6689465004133 0.8249409735123279 0.004651370998893226 2 2 2.1359980440949196 0.4945076125016832 0.4945076125016832 CBL 306 326.9156494140625 13.908212804384164 552.4955282746051 0.5116410559668761 0.0022336956748661868 1 1 0.6314197431097239 0.30019728430890225 0.30019728430890225 CBLB 806 819.9350814819336 25.538733200799612 1030.7663553022605 0.6878245569306642 0.0005266213789854527 0 0 0.373367401777073 0.6557705979735924 0.6557705979735924 CBLC 178 188.9005889892578 11.374629146847093 275.79864747319573 0.592242573065254 0.010197043881412338 1 1 1.665582094874784 0.6526645642804025 0.6526645642804025 CCND1 139 124.45777893066406 19.005810693449433 42.881630892095 2.5096270991800846 0.001094636966480804 0 0 0.11780144018050355 0.5554919475745336 0.5554919475745336 CCNE1 160 162.02246856689453 9.761126414541543 275.5184046122461 0.5084907686815598 0.009734544971485834 1 1 1.3637957848129463 0.5693707045008117 0.5693707045008117 CD79B 93 80.50835418701172 8.981246948242188 80.35420733509615 0.8663447949703428 0.02005361329680608 1 1 1.3960212457057382 0.5775230235430353 0.5775230235430353 CDC42EP2 61 55.98795700073242 5.998034477233887 87.13072448824485 0.5556249489607926 0.007968962999323096 0 0 0.38579347136190467 0.6597549090473679 0.6597549090473679 CDC73 249 269.86703872680664 14.836480648144658 330.85514925213084 0.7052943236859001 0.00014050101802054335 0 0 0.032785948906891155 0.5161263718006358 0.5161263718006358 CDH1 297 274.89952087402344 14.561338523032624 356.40629720969923 0.6669404486027614 0.009111000032303125 5 5 2.1657008864992764 0.0465637445677492 0.0465637445677492 CDK4 61 59.04027557373047 6.19516658782959 90.82193986558336 0.5621031840521369 0.0007572924271425307 1 1 0.03866076408248232 0.019325504604497407 0.019325504604497407 CDK6 251 281.88646697998047 15.563469597454457 328.04665186069803 0.7430141080956595 0.0005160495160171728 0 0 0.1257836070671141 0.5590865490101875 0.5590865490101875 CDK8 134 142.78156280517578 9.350142011768389 233.1888862855592 0.5294472857160013 0.00014197793026868495 0 0 0.01752876889621248 0.5086876932055139 0.5086876932055139 CDKN2A.p14arf 203 160.64028930664062 12.910776297304038 154.81186505852867 0.8972401062115841 0.006496802587523137 1 1 0.9024280611017348 0.410930496975845 0.410930496975845 CDKN2A.p16INK4a 247 166.69680786132812 13.130415069241078 161.174991901739 0.8943099642227583 0.006427621387626725 2 2 0.9264799258393405 0.15255243449765482 0.15255243449765482 CDKN2B 74 73.45878601074219 7.04019832611084 108.87237738931545 0.5834242594150028 0.003440587265853088 0 0 0.21854192676708042 0.5980670753524187 0.5980670753524187 CDKN2C 85 78.38217163085938 9.841509819030762 63.43239704198484 1.068475606830666 0.0006701142427841924 0 0 0.0454176420932372 0.5221930846490442 0.5221930846490442 CEBPA 69 64.96675109863281 6.054477691650391 115.14071737623402 0.4878885893915005 0.012223745651780586 1 1 0.6866792066099782 0.32361803504004727 0.32361803504004727 CHEK1 241 270.5784378051758 14.747260976979007 336.63838785737755 0.6950050975016513 0.005752831994259919 0 0 1.3459636132170782 0.869505891215826 0.869505891215826 CHEK2 305 381.206063079834 15.046398751090234 641.8809176508825 0.5135275855324489 0.0034921940473695433 1 1 1.1511094265637496 0.5014868138942832 0.5014868138942832 CREBBP 707 660.5876083374023 19.866529426065014 1105.6478752528405 0.5166209697032542 0.0015765839769440553 1 1 0.9005461510252839 0.4106178205779645 0.4106178205779645 CRKL 170 188.72262954711914 9.894435765069318 363.80267783117574 0.44855585603850745 0.000237057791506998 0 0 0.03868447046987848 0.5189719018378139 0.5189719018378139 CSF1R 260 265.568058013916 12.962375417265731 419.74205537564745 0.5470812067007597 0.016118354449130703 3 3 3.701305928579843 0.6095006322863057 0.6095006322863057 CTNNB1 298 198.96324920654297 11.283082556403473 310.949739751669 0.5532750807050861 0.0005181265607143562 0 0 0.08913887813983001 0.5426348924260029 0.5426348924260029 CYLD 344 363.7966079711914 16.78876422668122 469.547822135671 0.6699420812189624 0.0019103425071453975 1 1 0.6009361467391043 0.2868924557772835 0.2868924557772835 DAXX 53 63.04509353637695 5.847662448883057 116.23528798986257 0.46899880985971315 0.028825003636907053 0 0 1.5713723514076556 0.8950207631971953 0.8950207631971953 DDR2 404 427.16414642333984 19.130766585677364 498.5685060117387 0.7408467764913835 0.0011251995188533578 0 0 0.41560692421268963 0.6699730548622687 0.6699730548622687 DICER1 303 311.2045669555664 14.650816269693266 451.1991566475622 0.5963979276076566 0.004165142924285449 0 0 1.1208159778778481 0.8367664627660346 0.8367664627660346 DIS3 160 185.0285987854004 10.455603069951266 313.1695618472305 0.5108786557692006 0.004116414596030256 2 2 0.6585919418331561 0.08556251609771617 0.08556251609771617 DNMT1 389 407.9320602416992 16.52885862350236 609.1018905794692 0.5791036930239601 0.008199102442088404 7 7 2.8920952665187722 0.01930490509206964 0.01930490509206964 DNMT3A 439 417.37299728393555 15.890143666144631 689.9109671711776 0.5231060496490282 0.0007007570722455685 0 0 0.25290084525238804 0.6117095683425771 0.6117095683425771 DNMT3B 248 248.30680084228516 12.909810633293091 369.94527542816496 0.5803761703627173 0.0054096707766871695 2 2 1.1614964673957495 0.21793547761846613 0.21793547761846613 EGFR 686 608.7431182861328 19.966962850666334 929.488689582385 0.5663023950793266 0.004719524583299419 4 4 2.4842240417543864 0.17309757683739146 0.17309757683739146 EIF4EBP1 54 60.289100646972656 5.534670829772949 118.65717857102784 0.4393425143305555 0.003707381148834732 1 1 0.1932700174807432 0.09607572323873559 0.09607572323873559 EP300 331 353.06505966186523 14.045198614067052 631.9077930576829 0.48312495688254736 0.0031265983102368657 1 1 0.9545205277954921 0.4311272615321319 0.4311272615321319 EPHA3 1625 1591.1051864624023 45.77122512692427 1208.405542911342 1.138530386041814 0.0008454657448766365 2 2 1.163197207525375 0.21836010126464944 0.21836010126464944 EPHA5 2424 2423.9445037841797 55.03778554746848 1939.650315932269 1.0805818637316063 0.0004922422288429896 0 0 1.0317155688362232 0.8217536074012755 0.8217536074012755 EPHA6 2284 2310.3109130859375 56.252255558077024 1686.789841585486 1.1843168162088589 0.0007426509307200621 2 2 1.4835889926186843 0.3118485673600738 0.3118485673600738 EPHA7 947 1036.3046035766602 36.720943840380116 796.4292176959266 1.1251195901741642 0.0001892497466238079 0 0 0.1695825562220633 0.5779838454931282 0.5779838454931282 EPHA8 260 289.9376220703125 15.128476280360244 367.2981729774953 0.68256536578218 0.0019279046505673002 0 0 0.4833353581495271 0.6915405238192436 0.6915405238192436 EPHB1 1061 1066.196257019043 40.096629859502634 707.0637367691759 1.3038782252039585 0.00019299483199515917 0 0 0.17792676245658606 0.5814887718364312 0.5814887718364312 EPHB4 183 205.1724090576172 11.90891497299491 296.8202500443352 0.5977008513400129 0.004634905038988865 0 0 0.8222771873327869 0.7800351449752044 0.7800351449752044 EPHB6 88 93.49292755126953 9.467881202697754 97.51062007154474 0.8290587059289857 0.020816864365520528 4 4 1.682877542127526 0.06103788008222705 0.06103788008222705 ERBB2 251 243.66199111938477 12.606589291539402 373.5772055063629 0.5639828046391866 0.0057341795404010736 1 1 1.2081407102832382 0.5204282078705561 0.5204282078705561 ERBB3 198 184.35169219970703 10.71557857410467 295.9804366065551 0.5385705046682193 0.006985135315075911 1 1 1.1134748068891251 0.4883603151517748 0.4883603151517748 ERBB4 2954 3124.540596008301 64.48932123199296 2347.452058646998 1.1509272779584694 0.0003266214885511741 0 0 0.8824484987919332 0.7930814118336782 0.7930814118336782 ERG 501 560.2198333740234 22.819028871299952 602.7297723742408 0.8037005747019794 0.00044085323849460254 0 0 0.21355559725451595 0.5961310980795469 0.5961310980795469 ESR1 775 673.9690933227539 29.623646749429653 517.6103144168537 1.1258888093576989 0.0018376954026129923 1 1 1.0709568014762383 0.4736183334060282 0.4736183334060282 ETV1 435 490.8694305419922 25.757178684236393 363.19126251516695 1.1686623100596112 0.0002621838981691887 1 1 0.11128341543829702 0.055532195243333804 0.055532195243333804 ETV6 268 297.9983100891113 14.77299971177808 406.90237411719806 0.6332599476277427 0.0004919433609427584 0 0 0.12676149378482365 0.559519425603848 0.559519425603848 EZH2 280 260.55427169799805 13.685466361032796 362.47427706032016 0.6215548341614798 0.0007810669073419923 0 0 0.17597253025486287 0.5806615839101503 0.5806615839101503 FAM46C 75 70.95051574707031 8.615581512451172 67.81752281083038 0.9046322741719555 0.0047585605612856085 0 0 0.2919373092221598 0.6263582876373219 0.6263582876373219 FAS 167 209.55740356445312 11.064897190509841 358.68337837713887 0.5051847132260401 0.013160399289221615 1 1 2.38468224467018 0.7971763656933946 0.7971763656933946 FBXW7 167 134.3011589050293 8.893962678403406 228.01788612852997 0.509294854370533 0.0026488285076584793 0 0 0.30760404723433604 0.6323206050592263 0.6323206050592263 FGFR1 182 241.1216278076172 12.606599300528442 365.8275728831465 0.5699256122143361 0.002179152259405235 1 1 0.4543412682455283 0.2208703319152029 0.2208703319152029 FGFR2 631 638.7192268371582 21.121485022039167 914.4734055730323 0.6039449480810172 0.00039576725136848353 0 0 0.21857892589373568 0.5981594810351748 0.5981594810351748 FGFR3 115 99.33756256103516 7.73144137935021 165.084410915928 0.5203144395404379 0.009208537274903863 2 2 0.7909747013128781 0.11734420127896075 0.11734420127896075 FGFR4 117 117.30685806274414 8.72149758773768 180.91087562599154 0.5606827185293473 0.011428076433141858 0 0 1.1591909514880308 0.8425488689295564 0.8425488689295564 FH 247 263.23863983154297 17.253970533924697 232.76687293710506 0.977883029153461 0.0037928066245679045 0 0 0.8633139969159082 0.7887819239174758 0.7887819239174758 FLCN 140 159.64404678344727 9.613335611596186 275.77649504970316 0.5005574431908311 0.003618877134820663 1 1 0.49955695513068843 0.24156650635042504 0.24156650635042504 FLT1 1408 1437.2544250488281 38.59402454233214 1386.8425935506305 0.8961174330284526 0.0033972562635772876 5 5 4.222021161011482 0.332520535844358 0.332520535844358 FLT3 812 832.0660705566406 29.82271667373091 778.432968065685 0.924261867046723 0.0053471135896271125 5 5 3.8471194074027 0.2666389683023281 0.2666389683023281 FOXL2 79 72.2826156616211 6.8992719650268555 109.76431963753417 0.5694178972187168 0.003429610576094916 0 0 0.21435672482373258 0.5963854218366198 0.5963854218366198 GATA2 167 161.4364242553711 12.254599600578912 173.54208353375506 0.8043687051277949 0.0010555947039446126 0 0 0.14735238697976824 0.568478112447209 0.568478112447209 GATA3 319 292.5018844604492 18.075273997856804 261.87109130489085 0.9658274702979899 0.0005095721153477617 1 1 0.12888214819851443 0.06427193728649001 0.06427193728649001 GNA11 144 189.6651611328125 10.438067843616903 330.16793848904354 0.49671938538464405 0.0007285743430977575 0 0 0.1194867864058322 0.55630254267268 0.55630254267268 GNAQ 185 192.8097381591797 12.111060627492574 253.45074567838742 0.6577999479275433 0.00030847779712005766 0 0 0.051429383573320386 0.52506216010945 0.52506216010945 GNAS 355 306.46598052978516 19.193307255647408 254.9558099981015 1.0393834620745321 0.027700800298656552 13 13 7.340624890095084 0.029627349203684997 0.029627349203684997 GOLPH3 163 152.69580841064453 12.28014015607478 154.61356146490388 0.8539608772946337 0.0013050269096404846 0 0 0.1723078350158911 0.5790996086079986 0.5790996086079986 GRIN2A 1011 1124.9495849609375 36.664807891670605 941.3850390266928 1.0332947219786088 0.0017982400928070333 2 2 1.7491988345744232 0.38877269258248326 0.38877269258248326 GSK3B 299 272.63123321533203 14.462272506729356 355.3678502448519 0.6633701358457963 3.946545929823843e-05 0 0 0.009303603914631153 0.5046301693201648 0.5046301693201648 HDAC2 138 152.67578125 11.300764145990517 182.52597623132476 0.723275766605664 0.007863662574768573 0 0 1.0381341176440253 0.8224210891622538 0.8224210891622538 HIF1A 323 341.2660827636719 16.02091423605359 453.74480291084427 0.6503391617329805 0.002884601785932599 0 0 0.851211414400544 0.7863809880867 0.7863809880867 HMGA2 188 195.07623291015625 14.949357025515457 170.2800201281654 0.9906017954070747 0.00681421522346652 1 1 1.1494197364338656 0.5003946091973441 0.5003946091973441 HNF1A 129 142.58739471435547 10.089509531313313 199.72027615082925 0.6173300520275361 0.007129067792768571 1 1 0.8789664970383619 0.40195690119050465 0.40195690119050465 HRAS 72 49.04119873046875 5.316126346588135 85.10039310760972 0.49829663481196584 0.0006574000307458332 0 0 0.027877205755487248 0.5137438913255248 0.5137438913255248 HSP90AA1 215 244.8876724243164 12.513258142961476 382.99494234049047 0.5528818430867256 0.007616533577542885 0 0 1.612808217812419 0.8999984006012555 0.8999984006012555 IDH1 179 135.1396026611328 10.57865045684576 163.1942079462794 0.7160384439147056 0.0014080513723587654 0 0 0.16453548704397833 0.575821015435769 0.575821015435769 IDH2 140 175.73119735717773 9.732862886443812 325.9991936499076 0.4661125383149465 0.0017059089428189899 0 0 0.2592168073100319 0.6141324043928622 0.6141324043928622 IGF1R 695 676.037899017334 22.309809481516943 918.2276444640042 0.6366183064953588 0.0018801723417673725 0 0 1.0990745368268169 0.8333008306250085 0.8333008306250085 IGFBP7 214 257.2334747314453 14.273533161939184 324.78202983826225 0.6848475961758422 0.001630611944451334 1 1 0.36269080611210686 0.17799247708106625 0.17799247708106625 IKBKE 159 183.4014778137207 11.125864137018105 271.7303555698905 0.5836105269729411 0.009468485082474392 2 2 1.5015568284670031 0.3170604132278735 0.3170604132278735 IKZF1 500 464.19293212890625 25.053866793356594 343.27922339063826 1.1692555708286834 0.0022430910353110245 0 0 0.9003344465205236 0.796543491185828 0.796543491185828 INSR 617 640.4505958557129 44.840332369334405 204.00162270744207 2.7146288186641176 0.0031632077606345453 0 0 1.751748663157109 0.9126137689096198 0.9126137689096198 IRS1 146 145.96939849853516 10.590833393271634 189.96052649703273 0.6644417249471672 0.01657186751983711 4 4 2.0916630013609305 0.11152327651567859 0.11152327651567859 IRS2 68 56.87335968017578 9.580843925476074 35.23791772996297 1.3955875614632345 0.06734685951231421 6 6 3.3119568965190056 0.09372164774941627 0.09372164774941627 JAK1 265 294.92240142822266 13.638554855363452 467.6046415610309 0.5453651615148896 0.0026816922304601083 2 2 0.6838724973577983 0.09131035019524869 0.09131035019524869 JAK2 475 534.5973052978516 19.681400612304987 737.8048873503286 0.6265326107962648 0.0012647925855254942 1 1 0.5846615310765353 0.27975348495604413 0.27975348495604413 JAK3 189 233.84190368652344 13.23819981842979 312.02314623829096 0.6480282957141164 0.015068438661073259 4 4 3.0468357006780162 0.27833062166428085 0.27833062166428085 JUN 82 73.08409881591797 7.266222953796387 101.16454984940123 0.6246733609714848 0.0005695239121389633 0 0 0.03599094936152928 0.5176724007246986 0.5176724007246986 KDR 660 667.6764068603516 28.074394406758174 565.6024300128335 1.0207354705190423 0.006689813121859733 7 7 3.8622329038548693 0.07072305452328195 0.07072305452328195 KEAP1 212 186.23590698242188 10.9320225698594 290.2189706059613 0.5548761577566814 0.001983732303453379 0 0 0.31945149656817506 0.636662451744772 0.636662451744772 KIT 652 707.1291580200195 29.7945260153448 563.2802566749136 1.0855070777101594 0.00820422424020315 5 6 5.016429473217479 0.31388417814922065 0.47425268385540686 KLF6 69 97.92425537109375 11.34950065612793 74.44354516399555 1.1374221307004369 0.0049467258860684095 0 0 0.418857760540881 0.6707147846168195 0.6707147846168195 KMT2A 349 407.3869285583496 15.349573483193542 704.403581742082 0.5000851722522142 0.00631195579399502 0 0 2.2234608243684018 0.9456932189032142 0.9456932189032142 KMT2C 1140 1167.6476524353027 26.76823796289977 1902.760171503703 0.5306231598762349 0.008970620943257464 10 10 9.057175008268475 0.36059274593072355 0.36059274593072355 KMT2D 273 229.71839141845703 10.888843402980305 445.0697000076031 0.44629927451396023 0.024947440527628813 4 4 4.955416992364968 0.6389130699159303 0.6389130699159303 KRAS 367 149.98456268310548 11.399325299894013 173.11505094938767 0.7491524022354524 5.891154427771829e-05 0 0 0.007640212037255639 0.5038054662491329 0.5038054662491329 LDHA 142 139.17755126953125 10.96162660587952 161.20866208591525 0.7465162412111205 0.0015577213172958074 0 0 0.1874637919680575 0.5854252817449872 0.5854252817449872 LGR6 460 482.95530700683594 18.433851661469717 686.407007734266 0.6083922557129119 0.004446854283287842 5 5 1.857027283479755 0.026479639336413834 0.026479639336413834 MAGI2 1476 1549.2105255126953 44.15653909538228 1230.922822958917 1.0882735100574408 0.0019372411642913194 1 1 2.5950908771605548 0.8282485072261291 0.8282485072261291 MAP2K1 167 172.5284767150879 11.270605064996076 234.3295788567632 0.636637357378577 0.00044190062930415074 0 0 0.06592404560191448 0.5318946748659381 0.5318946748659381 MAP2K2 243 248.3574676513672 12.007844018030204 427.7838358218203 0.5020087602568907 0.001067240620212339 0 0 0.22919123918243567 0.6023873725163287 0.6023873725163287 MAP2K4 332 354.61034393310547 16.048724399244065 488.2269642340831 0.6280411232093501 0.00045179422354490594 0 0 0.13853213163434766 0.564673807891435 0.564673807891435 MAP3K8 174 205.42925262451172 14.74470937932908 194.11189008077713 0.9151000751014852 0.002183120243819329 0 0 0.3877915898586662 0.660591854128878 0.660591854128878 MCL1 158 141.47960662841797 8.929617959072948 251.0278636151495 0.48733808996998695 0.009630852616280194 0 0 1.1781945883760891 0.845658171814828 0.845658171814828 MDM2 308 292.43257904052734 13.163920242238058 493.49303121264035 0.5123929827526027 0.0034015211763662066 1 1 0.8601166934396846 0.3947877952026705 0.3947877952026705 MDM4 178 209.26602172851562 10.47679326808314 398.9704106140989 0.45354091688788717 0.0034525821094008925 0 0 0.6247426813135487 0.7321695729436808 0.7321695729436808 MEN1 51 54.749488830566406 6.740067481994629 65.9829377965734 0.717475150402386 0.006460307200816413 0 0 0.305838166928704 0.6314867949451843 0.6314867949451843 MET 593 626.8061813354492 21.272059593836723 868.2553326408628 0.624229450759241 0.0041441416758217975 2 2 2.246085623724745 0.5228359455444783 0.5228359455444783 MITF 509 544.3795166015625 23.70393819556428 527.4272193353786 0.8924783297945766 0.0010618182207433127 0 0 0.4998162737037745 0.6966071499387275 0.6966071499387275 MLH1 366 408.7491645812988 15.426633513689824 702.0554767212227 0.5034355612775366 0.0025113185144169116 1 1 0.8875996446881957 0.4055679269646846 0.4055679269646846 MLST8 62 59.54033279418945 7.321844577789307 66.12740860399245 0.7785530260529995 0.009374433987897633 0 0 0.48263049154684357 0.6908797617427136 0.6908797617427136 MPL 137 123.91341781616211 9.462038638568218 171.50122940078066 0.6247547138084223 0.012270541251390824 3 3 1.3147418853383674 0.09606774151178589 0.09606774151178589 MSH2 379 438.8856887817383 16.21267930781281 732.8131510024233 0.5178650573667991 0.0013620739564356608 2 2 0.5169047842892841 0.05558463883856006 0.05558463883856006 MSH6 209 204.50153350830078 12.38730229365339 272.545908040253 0.6488067302188888 0.012087822760571548 2 2 2.1374850984907847 0.4945721506124611 0.4945721506124611 MTOR 669 722.4847717285156 21.120785578646863 1170.1384766908077 0.5338876572963265 0.0005402842637150936 0 0 0.3375277305536029 0.6432165416040246 0.6432165416040246 MYB 219 268.5742835998535 14.187939264221674 358.33580947766654 0.6480860279299562 0.0022850264685516006 1 1 0.5306572526723797 0.255649285115506 0.255649285115506 MYC 176 170.05612182617188 13.395880775707218 161.1543356147298 0.9124492527049775 0.003287791575073345 1 1 0.48345381552355804 0.23418100713993267 0.23418100713993267 MYCN 78 83.70323181152344 9.33009147644043 80.48457397906382 0.8992656822857892 0.023032452144210853 0 0 1.6670201419926998 0.9039741792650926 0.9039741792650926 NCOA2 523 554.1361846923828 23.013760683931995 579.7727980554122 0.8264510167071483 0.0013383706836217744 0 0 0.6412854235081102 0.7365991343354501 0.7365991343354501 NF1 817 858.133470916748 22.98499503568384 1393.8654547166639 0.532344081626557 0.00046986589702459927 0 0 0.34864802538219763 0.6471638907084287 0.6471638907084287 NF2 267 279.3356056213379 12.223362905730253 522.2412612566944 0.46250193958228 0.0002442264401308921 0 0 0.05898986729262537 0.5286402690472157 0.5286402690472157 NFE2L2 202 143.85562896728516 9.919180934921373 210.33042329233083 0.5914025701234211 0.007889795364621581 2 2 0.9814112738766414 0.16737979863346936 0.16737979863346936 NFKB1 483 508.11487197875977 18.32645525862301 768.7176823340984 0.5715490124105956 0.0036638168581817885 0 0 1.6097339598779858 0.8998612001868771 0.8998612001868771 NFKB2 95 113.7198257446289 9.314946813698878 149.04300975191984 0.6597554959566672 0.007652340330253378 0 0 0.7524695070811352 0.7639528180271092 0.7639528180271092 NKX2-1 88 107.7188491821289 9.560213088989258 126.95454842934217 0.7336718956633067 0.0006455529112116992 0 0 0.060128724615216685 0.5291716413879557 0.5291716413879557 NOTCH1 337 268.9879913330078 13.659895216788414 387.76717955529017 0.5998190950408541 0.012470610153571702 1 1 2.90054119504675 0.864387333126944 0.864387333126944 NOTCH2 593 658.259375 22.559582202375513 851.3967763111214 0.6685339931457693 0.002942405066724509 2 2 1.6747807330240925 0.3674461788930189 0.3674461788930189 NOTCH3 370 396.16800689697266 19.283241557785676 422.08383310949597 0.8115945572675539 0.011771298358405017 3 3 4.032387050243032 0.6685453127238262 0.6685453127238262 NOTCH4 303 298.72198486328125 14.989700333128011 397.14442563936103 0.6503949468149905 0.018246796982104393 6 6 4.713160936693451 0.26618246031473464 0.26618246031473464 NPM1 114 152.76282501220703 10.436151746237103 214.26665591456648 0.6164836070533078 0.0003914006325287751 0 0 0.051700845739879035 0.5251905863102335 0.5251905863102335 NRAS 75 73.89339447021484 7.401847839355469 99.6623053153495 0.6411108574198069 0.00011899350293174211 0 0 0.0076030406080792 0.5037869614035249 0.5037869614035249 NTRK1 249 225.88141632080078 13.308966885620237 288.0529421285084 0.6780576654013984 0.0067444202373438365 3 3 1.3172965920554571 0.09624140439151044 0.09624140439151044 NTRK2 913 1002.4882125854492 33.18852349270079 912.3945578342133 0.9500687467393777 0.0006368576199638332 0 0 0.5520521015951804 0.7120684030306591 0.7120684030306591 NTRK3 1470 1507.1678314208984 44.51227214990876 1146.4726663252895 1.13672746775874 0.0005030510613957041 0 0 0.6555897109238689 0.7403834435299914 0.7403834435299914 PAK7 588 590.5762634277344 26.942676684814117 480.4746690683188 1.0628303183367398 0.003190897123190245 0 0 1.629473242737301 0.901713006142058 0.901713006142058 PARK2 1313 1314.7870864868164 40.949549480533044 1030.890656980345 1.1028114575376464 0.0020457015955897147 0 0 2.325713195842741 0.9510149869610758 0.9510149869610758 PARP1 310 365.6181297302246 15.201123335712866 578.5009547854945 0.5464898320377103 0.0032051203991653905 1 1 1.0132824347949396 0.4528878038940751 0.4528878038940751 PAX5 325 375.04444885253906 20.25474019854076 342.85629637241465 0.9458647821796728 8.031469716902893e-05 0 0 0.026045710624464785 0.5128542415081916 0.5128542415081916 PBRM1 652 694.0727767944336 18.594342722918345 1393.3119388880455 0.43073989258085343 0.0003765487502667155 1 1 0.22598762835345032 0.11213205063269102 0.11213205063269102 PDGFRA 488 543.9630584716797 26.379670720483062 425.2066748836306 1.1061850296724023 0.006822180958304362 2 2 3.2088623309906654 0.7249353364685751 0.7249353364685751 PDGFRB 196 188.04603576660156 12.190593231606819 237.94615115609042 0.683351168332349 0.013480837232955213 2 2 2.1919946544254856 0.5085186700617692 0.5085186700617692 PHOX2B 232 199.8005828857422 14.450551516264772 191.17216414846644 0.9037130162851875 0.008402744877851087 3 3 1.4516983121750813 0.12003232990986502 0.12003232990986502 PIK3C2G 2119 2090.669792175293 50.59485420908875 1707.4900861841245 1.0587311635064525 0.004320547109183294 11 11 7.81056826067547 0.13273104573733624 0.13273104573733624 PIK3CA 465 406.46752166748047 19.72641584203264 424.5758922739994 0.8278067469455248 0.00035375625141382367 1 1 0.12433357349533558 0.06201521098712438 0.06201521098712438 PIK3CB 605 579.3568115234375 19.03141700778111 926.7230898301908 0.540573281959012 0.0010630595611590952 0 0 0.5325521697533387 0.7064027621841968 0.7064027621841968 PIK3CD 108 117.66049194335938 7.627345804093708 237.96574571247297 0.42753793630971476 0.015028617956438225 3 3 1.529002330769318 0.13439545353147847 0.13439545353147847 PIK3CG 457 500.84815979003906 25.85370933234396 375.2895237707414 1.153979475060393 0.005685904356528761 4 4 2.462431032890912 0.16965517996114363 0.16965517996114363 PIK3R1 315 315.91342544555664 13.682034537835928 533.1320609207006 0.5123794762060339 0.0015656957701668606 0 0 0.4276947350847947 0.6739388871604622 0.6739388871604622 PIK3R2 155 169.7697639465332 10.779094040515785 248.0596735613217 0.5917831840048174 0.008095968421003585 0 0 1.1884682759979768 0.8472232398788198 0.8472232398788198 PIK3R3 328 364.5416374206543 16.4186492473446 492.9687955824919 0.6394199076614948 0.0022376475236680444 0 0 0.7053379647032663 0.752904660898821 0.752904660898821 PLK2 76 72.55290222167969 6.9239182472229 109.80085358057899 0.5713569525629754 0.004021777478286345 0 0 0.2523081449396865 0.6113848991194913 0.6113848991194913 PNRC1 76 78.99751281738281 6.6640214920043945 140.52515015189636 0.4860912496935379 0.02068787574673413 2 2 1.4131483650616516 0.29119205660193115 0.29119205660193115 PREX2 2867 2939.3829803466797 62.74580546009672 2194.537230412329 1.1581682775297546 0.00038197697640181966 0 0 0.9708492625979838 0.8105787215119432 0.8105787215119432 PRKAR1A 147 138.23370361328125 9.269968726463551 222.3675186761032 0.5375279325799364 0.0007172524394771789 0 0 0.08573228938061542 0.5410724605178467 0.5410724605178467 PRKCI 430 417.43751525878906 17.986314260163144 538.6399968688474 0.670118057582669 0.0005211451831346964 0 0 0.18810859857547288 0.5857240330167133 0.5857240330167133 PTCH1 378 409.69124603271484 16.904264512562793 587.3822373510027 0.603106929552811 0.003252524010116627 3 3 1.1522206087696354 0.07020636134083226 0.07020636134083226 PTEN 166 132.31365203857422 10.275639854769567 165.80268699142744 0.6900356608263644 0.00013100972034019731 0 0 0.014988791537578131 0.5074381756802062 0.5074381756802062 PTPN11 292 317.4507293701172 15.429526447797324 423.29921595890596 0.6484661464137138 0.0003509621038861111 0 0 0.0963374168830478 0.5459162545155265 0.5459162545155265 PTPRD 1363 1369.9521484375 41.82641348726759 1072.7772193475992 1.1042166678356742 0.0007161370962424724 3 3 0.8483205975776763 0.03289230337281438 0.03289230337281438 PTPRS 572 622.7746276855469 22.84308113686655 743.2800167321022 0.7244975099085138 0.0026362204829990447 1 1 1.4196166492048234 0.5863243648870868 0.5863243648870868 RAF1 240 234.68759536743164 12.422780477845842 356.8967954931602 0.5685987882943071 0.0007332434583308068 0 0 0.14879789090810472 0.5691150067871001 0.5691150067871001 RARA 139 168.60281372070312 12.175882925023151 191.7470578839662 0.7603167396283628 0.005491092934826086 1 1 0.8005381907079179 0.370856842949037 0.370856842949037 RB1 650 649.3809471130371 19.98420311591856 1055.9063805216797 0.531780699882121 0.001300484945992721 0 0 0.7302361265888104 0.7590415863348267 0.7590415863348267 REL 187 209.92974090576172 12.833105308126116 267.59896129931093 0.6783408786829171 0.010357021016925257 0 0 1.8800407837776798 0.9232049071434385 0.9232049071434385 RET 403 400.13990783691406 18.766226499119348 454.64228739242765 0.7610277321709547 0.008739765099848636 8 8 3.023918424820191 0.008433100427202795 0.008433100427202795 RICTOR 343 344.5673294067383 17.39102406796731 392.55262108617404 0.7589875614634766 0.0013609726887567394 1 1 0.40549168238401884 0.19816242366491282 0.19816242366491282 RPTOR 1054 1011.6710205078125 25.55717874759059 1566.9415566606417 0.558270853252112 0.0008886909517058341 0 0 0.7774071154648391 0.7701576206566094 0.7701576206566094 RUNX1 307 357.3256301879883 16.789260404277627 452.9655844827122 0.682114694094119 0.0003130036333457912 0 0 0.09671013519373683 0.5460857580670274 0.5460857580670274 SDHB 229 231.9755096435547 12.524339637303138 343.0635697018287 0.5846904204850416 0.000823513749133759 0 0 0.16518531473747575 0.5761148527807622 0.5761148527807622 SETD2 571 587.6779899597168 18.807049679802443 976.4218911202897 0.5204276486596787 0.0069321898925857415 5 5 3.522640464981074 0.21237347282401772 0.21237347282401772 SHQ1 271 314.0004196166992 13.706037539650234 524.8517177786689 0.5173113995969365 0.0069946373561081765 1 1 1.8991264159636716 0.707663871064901 0.707663871064901 SMAD4 271 198.14374160766602 10.120575248949917 383.31015283478223 0.4469804003777111 0.00024641080098737985 0 0 0.042218086299760774 0.5206685421477887 0.5206685421477887 SMARCA4 564 543.2767906188965 18.210438220328193 890.0235741715297 0.527810572303333 0.0016482968953420633 0 0 0.774310298872888 0.769411571903154 0.769411571903154 SMARCB1 213 231.27394104003906 11.06974615519353 436.49379880636576 0.4581493409468273 0.0011128392837338823 0 0 0.2225448724429915 0.5997377574867683 0.5997377574867683 SMO 239 247.3600082397461 14.507249166059943 290.729320284931 0.7356971895682267 0.0028187780954768583 1 1 0.602904906057977 0.2877164320399105 0.2877164320399105 SOCS1 60 62.18384552001953 7.525132656097412 68.28523857766554 0.7874249797114179 0.003964376501208489 0 0 0.21316255259548197 0.5958534481096626 0.5958534481096626 SOX2 111 111.48675537109375 11.184466361999512 99.36101450777021 0.9702099010978096 0.000909277548756537 0 0 0.08765530140202976 0.5419440040160943 0.5419440040160943 SPOP 122 120.82868957519531 8.424131375689285 205.72632525411802 0.507853722377574 0.0002933606331975 0 0 0.030649990413500815 0.5150914138703996 0.5150914138703996 SRC 159 184.4766082763672 9.4508786126076 381.011636989548 0.41866003768823706 0.002255060550442889 0 0 0.3597145095746516 0.6510030140376921 0.6510030140376921 STK11 189 174.6679229736328 11.201121209739952 243.16626168447735 0.621109655951089 0.0022687121109980944 1 1 0.34265019918588036 0.16846274270650657 0.16846274270650657 SUFU 281 283.5792655944824 12.259643803993178 535.0486128596239 0.4582892542258705 0.00029450444940117134 0 0 0.07221456128936138 0.5348321026301359 0.5348321026301359 TBK1 366 420.2334442138672 16.99922532799758 611.1150288408808 0.5946016249013233 0.001120229420983315 1 1 0.4070577525486736 0.19890588867448458 0.19890588867448458 TEK 681 755.1026931762696 25.515408529764706 875.8041241929989 0.7455168719197953 0.0012490916426698738 2 2 0.8155653480531441 0.12330615151271238 0.12330615151271238 TERT 505 496.7741394042969 23.019839771763035 465.70764411293294 0.9223676367510023 0.022232301210095347 5 5 9.54996633539494 0.9356218273270951 0.9356218273270951 TET1 497 489.0178909301758 18.49258444819207 699.2851010575716 0.6046846111349605 0.02265096453231949 10 10 9.577891027073134 0.4262159772561629 0.4262159772561629 TET2 293 322.4669761657715 15.030009439287586 460.31166810901567 0.6057476036457488 0.024323124534349212 8 8 6.782082240374267 0.3065862345661038 0.3065862345661038 TGFBR2 452 440.8344078063965 17.156046118504083 660.2623890533217 0.5773210180112651 0.0015786477905821716 0 0 0.6017542605504322 0.7260000601824157 0.7260000601824157 TMPRSS2 287 279.5621795654297 13.898820606027277 404.57676414605754 0.5974972687714464 0.009274948492323236 2 2 2.2420658688254096 0.5215566171305863 0.5215566171305863 TNFAIP3 96 127.92522430419922 9.537496847288379 179.90513498213204 0.6148526807423226 0.014412619190945029 2 2 1.5942540988885958 0.34398933508838947 0.34398933508838947 TOP1 461 435.511661529541 17.57434312857431 614.1032190389802 0.6132207722957407 0.00017789419193020803 0 0 0.06699154605132693 0.5323967377734965 0.5323967377734965 TP53 775 54.73919525146484 5.528659057617188 98.02959298210779 0.48283600967479545 0.025188371247455717 2 2 1.1922214664944926 0.22700683324311982 0.22700683324311982 TP63 437 489.77112579345703 21.43322084563219 522.1694723828891 0.8110360208104925 0.00023422585973665623 1 1 0.09919424195387214 0.04951927878264516 0.04951927878264516 TSC1 207 252.65008926391602 12.920382592222277 382.37383260767297 0.5713335599760397 0.006175953709867239 0 0 1.349217394003606 0.8699699605469224 0.8699699605469224 TSC2 250 255.56520080566406 13.248558004777557 372.1056052031762 0.5938735030206433 0.00979095493373475 1 1 2.1636410488636377 0.7600058747763603 0.7600058747763603 TSHR 865 796.6045837402344 31.08035121584921 656.9219396377433 1.048545975662127 0.0026542795537689958 0 0 1.8283018804025728 0.9194526095887867 0.9194526095887867 VHL 157 124.49189376831055 10.847261486973164 131.7170295160254 0.8172550046333983 0.00668525343763723 1 1 0.7196434761278508 0.33752335373199627 0.33752335373199627 WT1 255 238.67523956298828 16.094035478811527 219.93017790423664 0.9383848440644454 0.004158002745884659 0 0 0.8581250545045032 0.7876676319190065 0.7876676319190065 YAP1 376 420.2864532470703 18.724759391471864 503.8001497776274 0.7213491807840178 0.000383917684402062 0 0 0.13952176213228604 0.5651045522447551 0.5651045522447551 YES1 347 360.4534606933594 14.13267000847892 650.5039859613381 0.4791347619194767 0.0013330442231200583 1 1 0.4154819869852349 0.2028460756695308 0.2028460756695308