Topologically associating domains (TADs) are contiguous segments of the genome where the genomic elements are in frequent contact with each other. Gene pairs that cooccupy a TAD are often functionally related and more likely to be coexpressed than random gene pairs, The TAD Map (bioRxiv preprint) provides a consensus estimate of the TAD layout for human and mouse, aggregated from multiple experimental datasets. It also provides tools to map any single-cell RNA-seq dataset to TAD signatures, where gene expression is mapped to TAD activation probabilities in each cell. It is described in the bioRxiv preprint, Deciphering the species-level structure of topologically associating domains by Rohit Singh and Bonnie Berger.

Estimated TAD Scaffold and Gene groups:

pip install tadmap