((kinase-sup:O, (kinase-sup:B, kinase-sup:A)), ((kinase-sup:C, ((kinase-sup:H, (kinase-sup:G, kinase-sup:F)), (kinase-sup:E, kinase-sup:D))), (kinase-sup:N, ((kinase-sup:I, (kinase-sup:K, kinase-sup:J)), (kinase-sup:M, kinase-sup:L))))) Core Residues: 167 Core RMSD: 0.505 Raw Score: 267.211 Reference structure: kinase-sup:A kinase-sup:A NVVG-------------------------------------------------------- 9 kinase-sup:B ----MELRVG-------------------------------------------------- 9 kinase-sup:C ----------WKQAEDIR------------------------------------------ 17 kinase-sup:D ------------------FY---------------------------------------- 16 kinase-sup:E --------------------KGSEQESVKEFLAKAKEDFLKKWENPAQNTAHL------- 40 kinase-sup:F -----------------------------------------------------YDNYVFD 5921 kinase-sup:G ------------------------------------------------------------ 23 kinase-sup:H ------------------------------------------------------------ 18 kinase-sup:I ------------------------------------------------------------ 45 kinase-sup:J ------------------------------------------------------------ 4 kinase-sup:K ------------------------------------------------------------ 6 kinase-sup:L ------------------------------------------------------------ 1 kinase-sup:M ------------------------------------------------------------ 5 kinase-sup:N ------------------------------------------------------------ 7 kinase-sup:O ------------------------------------------------------------ 175 kinase-sup:A ------------------------------------------------------------ 9 kinase-sup:B ------------------------------------------------------------ 9 kinase-sup:C ------------------------------------------------------------ 17 kinase-sup:D ------------------------------------------------------------ 16 kinase-sup:E ------------------------------------------------------------ 40 kinase-sup:F IWKQYYPQPVEIKHDHVL------------------------------------------ 5939 kinase-sup:G ------------------INDYDKFYEDIWKKYVPQPVEVKQGSVY-------------- 50 kinase-sup:H ----------------------------------------------KELY---------- 21 kinase-sup:I --------------------------------------------------DNQFYSVEVG 54 kinase-sup:J ------------------------------------------------------------ 4 kinase-sup:K ------------------------------------------------------------ 6 kinase-sup:L ------------------------------------------------------------ 1 kinase-sup:M ------------------------------------------------------------ 5 kinase-sup:N ------------------------------------------------------------ 7 kinase-sup:O ------------------------------------------------------------ 175 kinase-sup:A ------------------------------------------------------------ 9 kinase-sup:B ------------------------------------------------------------ 9 kinase-sup:C ------------------------------------------------------------ 17 kinase-sup:D ------------------------------------------------------------ 16 kinase-sup:E ------------------------------------------------------------ 40 kinase-sup:F ------------------------------------------------------------ 5939 kinase-sup:G ------------------------------------------------------------ 50 kinase-sup:H ------------------------------------------------------------ 21 kinase-sup:I DSTFTVL----------------------------------------------------- 61 kinase-sup:J -------ERPTFYRQELNKTIWEVP----------------------------------- 21 kinase-sup:K -------------------------AAGPEMVRGQVFDVG-------------------- 20 kinase-sup:L ----------------------------------------M------------------- 1 kinase-sup:M -----------------------------------------GLCRAD------------- 10 kinase-sup:N -----------------------------------------------SKARVYADVNVLR 19 kinase-sup:O ------------------------------------------------------------ 175 kinase-sup:A ---------------------------------------------VHYKVGRRIGEGSFG 24 kinase-sup:B ---------------------------------------------NRYRLGRKIGSGSFG 24 kinase-sup:C ---------------------------------------------DIYDFRDVLGTGAFS 32 kinase-sup:D ---------------------------------------------ENYEPKEILGRGVSS 31 kinase-sup:E ---------------------------------------------DQFERIKTLGTGSFG 55 kinase-sup:F ---------------------------------------------DHYDIHEELGTGAFG 5954 kinase-sup:G ---------------------------------------------DYYDILEELGSGAFG 65 kinase-sup:H ---------------------------------------------EKYMIAEDLGRGEFG 36 kinase-sup:I ---------------------------------------------KRYQNLKPIGSGAQG 76 kinase-sup:J ---------------------------------------------ERYQNLSPVGSGAYG 36 kinase-sup:K ---------------------------------------------PRYTNLSYIGEGAYG 35 kinase-sup:L ---------------------------------------------ENFQKVEKIGEGTYG 16 kinase-sup:M ---------------------------------------------QQYECVAEIGEGAYG 25 kinase-sup:N PKEYWDYEALTVQWGEQ----------------------------DDYEVVRKVGRGKYS 51 kinase-sup:O -----------------TTLKDLIYDMTTSGSGSGLPLLVQRTIARTIVLQESIGKGRFG 217 kinase-sup:A VIFEGTNLLN-----------------------------------------NQQVAIKFE 43 kinase-sup:B DIYLGTD---IAA--------------------------------------GEEVAIKLE 43 kinase-sup:C EVILAED------KRT-----------------------------------QKLVAIKCI 51 kinase-sup:D VVRRCIH---------KPT--------------------------------CKEYAVKII 50 kinase-sup:E RVMLVKH------------KET-----------------------------GNHFAMKIL 74 kinase-sup:F VVHRVTE---------------RAT--------------------------GNNFAAKFV 5973 kinase-sup:G VVHRCVE------------------KAT-----------------------GRVFVAKFI 84 kinase-sup:H IVHRCVE---------------------TSS--------------------KKTYMAKFV 55 kinase-sup:I IVCAAYD------------------------AVL-----------------DRNVAIKKL 95 kinase-sup:J SVCAAFD---------------------------TKT--------------GHRVAVKKL 55 kinase-sup:K MVCSAYD------------------------------NLN-----------KVRVAIKKI 54 kinase-sup:L VVYKARN---------------------------------KLT--------GEVVALKKI 35 kinase-sup:M KVFKARD------------------------------------LKNG----GRFVALKRV 45 kinase-sup:N EVFEGIN----------------------------------------VNN-NEKCIIKIL 70 kinase-sup:O EVWRGKW-------------------------------------------RGEEVAVKIF 234 kinase-sup:A PRRSDAPQLRD------------------------------------------------- 54 kinase-sup:B CV---------KTKHPQLHI---------------------------------------- 54 kinase-sup:C AK------------------EN-------------------------------------- 65 kinase-sup:D DV--------------------TGGGSFSAEEVQELREATLK------------------ 72 kinase-sup:E DK----------------------------------------QKVVKLKQIEHTLN---- 90 kinase-sup:F MT------------------------------------------------------PHES 5979 kinase-sup:G NT---------------------------------------------------------- 86 kinase-sup:H KV---------------------------------------------------------- 57 kinase-sup:I SR---------------------------------------------------------- 97 kinase-sup:J SR---------------------------------------------------------- 57 kinase-sup:K SP---------------------------------------------------------- 56 kinase-sup:L RT---------------------------------------------------------- 41 kinase-sup:M RV---------------------------------------------------------- 47 kinase-sup:N KP---------------------------------------------------------- 72 kinase-sup:O SS---------------------------------------------------------- 236 kinase-sup:A ------------------------------------------------------------ 54 kinase-sup:B ------------------------------------------------------------ 54 kinase-sup:C ------------------------------------------------------------ 65 kinase-sup:D ------------------------------------------------------------ 72 kinase-sup:E ------------------------------------------------------------ 90 kinase-sup:F DKETVRK----------------------------------------------------- 5986 kinase-sup:G -------PYPLDKYTVKN------------------------------------------ 97 kinase-sup:H ------------------KGTDQVLVKK-------------------------------- 67 kinase-sup:I ----------------------------PFQNQTHAKRAYR------------------- 110 kinase-sup:J -----------------------------------------PFQSIIHAKRTYR------ 70 kinase-sup:K ------------------------------------------------------FEHQTY 62 kinase-sup:L ------------------------------------------------------------ 41 kinase-sup:M ------------------------------------------------------------ 47 kinase-sup:N ------------------------------------------------------------ 72 kinase-sup:O ------------------------------------------------------------ 236 kinase-sup:A ----------------------------------------------------EYRTYKLL 62 kinase-sup:B ----------------------------------------------------ESKIY--- 59 kinase-sup:C ----------------------------------------------------EIAVL--- 70 kinase-sup:D ----------------------------------------------------EVDIL--- 77 kinase-sup:E ----------------------------------------------------EKRIL--- 95 kinase-sup:F ----------------------------------------------------EIQTM--- 5991 kinase-sup:G ----------------------------------------------------EISIM--- 102 kinase-sup:H ----------------------------------------------------EISIL--- 72 kinase-sup:I ----------------------------------------------------ELVLM--- 115 kinase-sup:J ----------------------------------------------------ELRLL--- 75 kinase-sup:K CQRTLR----------------------------------------------EIKIL--- 73 kinase-sup:L ------EGVPSTAIREISL---------------------------------LKELN--- 59 kinase-sup:M -------------------QTGEEGMPLSTIREVAV----------------LRHLE--- 69 kinase-sup:N ------------------------------------VKKKKIKR--------EIKIL--- 85 kinase-sup:O --------------------------------------------REERSWFREAEIY--- 249 kinase-sup:A AG--------------------------------------------------------CT 66 kinase-sup:B --KMMQG---------------------------------------------------GV 66 kinase-sup:C -------HKIK-----------------------------------------------HP 76 kinase-sup:D -----------RKVSG------------------------------------------HP 84 kinase-sup:E ----------------QAVN--------------------------------------FP 101 kinase-sup:F --------------------SVLR----------------------------------HP 5997 kinase-sup:G ------------------------NQLH------------------------------HP 108 kinase-sup:H ----------------------------NIAR--------------------------HR 78 kinase-sup:I --------------------------------KCVN----------------------HK 121 kinase-sup:J ------------------------------------KHMK------------------HE 81 kinase-sup:K ----------------------------------------LRFR--------------HE 79 kinase-sup:L ----------------------------------------------------------HP 61 kinase-sup:M --------------------------------------------TFE-----------HP 74 kinase-sup:N -----------------------------------------------QNLCG------GP 92 kinase-sup:O ----------------------------------------------------QTVMLRHE 257 kinase-sup:A GIPNVYYFGQEGLHN--------------------------------------------- 81 kinase-sup:B GIPTIRWCGA-----EGDYN---------------------------------------- 81 kinase-sup:C NIVALDDIYE----------SGGHL----------------------------------- 91 kinase-sup:D NIIQLKDTYE---------------TNTFF------------------------------ 99 kinase-sup:E FLVKLEYSFK--------------------DNSNL------------------------- 116 kinase-sup:F TLVNLHDAFE-------------------------DDNEM-------------------- 6012 kinase-sup:G KLINLHDAFE------------------------------DKYEM--------------- 123 kinase-sup:H NILHLHESFE-----------------------------------SMEEL---------- 93 kinase-sup:I NIISLLNVFT----------------------------------------PQKTLEEFQD 141 kinase-sup:J NVIGLLDVFT-------------------------------------------------- 91 kinase-sup:K NIIGINDIIR-------------------------------------------------- 89 kinase-sup:L NIVKLLDVIH-------------------------------------------------- 71 kinase-sup:M NVVRLFDVCT-------------------------------------------------- 84 kinase-sup:N NIVKLLDIVR-------------------------------------------------- 102 kinase-sup:O NILGFIAADN-------------------------------------------------- 267 kinase-sup:A -----------------------------------------------------VLVIDLL 88 kinase-sup:B -----------------------------------------------------VMVMELL 88 kinase-sup:C -----------------------------------------------------YLIMQLV 98 kinase-sup:D -----------------------------------------------------FLVFDLM 106 kinase-sup:E -----------------------------------------------------YMVMEYV 123 kinase-sup:F -----------------------------------------------------VMIYEFM 6019 kinase-sup:G -----------------------------------------------------VLILEFL 130 kinase-sup:H -----------------------------------------------------VMIFEFI 100 kinase-sup:I V----------------------------------------------------YLVMELM 149 kinase-sup:J -PARSLEEFNDV-----------------------------------------YLVTHLM 109 kinase-sup:K ------------APTIEQMKDV-------------------------------YIVQDLM 106 kinase-sup:L ----------------------TENKL--------------------------YLVFEFL 83 kinase-sup:M ---------------------------VSRTDRETKL----------------TLVFEHV 101 kinase-sup:N -------------------------------------DQHSKTP---------SLIFEYV 116 kinase-sup:O --------------------------------------------KDNGTWTQLWLVSDYH 283 kinase-sup:A G----------------------PSLEDLLDLCGRKF----------------------- 103 kinase-sup:B -G---------------------PSLEDLF-------NFCSRKF---------------- 103 kinase-sup:C --SG-------------------GELFDRI--------------VEKGFY---------- 113 kinase-sup:D ----KK-----------------GELFDYL--------------------TEKVTL---- 121 kinase-sup:E ------PG---------------GEMFSHL--------------------------RRIG 136 kinase-sup:F --------SG-------------GELFEKV------------------------------ 6028 kinase-sup:G ----------SG-----------GELFDRI------------------------------ 139 kinase-sup:H ------------SG---------LDIFERI------------------------------ 109 kinase-sup:I --------------D--------ANLCQVI------------------------------ 157 kinase-sup:J ---------------G-------ADLNNIV------------------------------ 117 kinase-sup:K ----------------E------TDLYKLL------------------------------ 114 kinase-sup:L -----------------H-----QDLKKFM------------------------------ 91 kinase-sup:M ------------------D----QDLTTYL------------------------------ 109 kinase-sup:N -------------------NN--TDFKVLY------------------------------ 125 kinase-sup:O ---------------------EHGSLFDYL------------------------------ 292 kinase-sup:A ------------------------------------------------------------ 103 kinase-sup:B ------------------------------------------------------------ 103 kinase-sup:C ------------------------------------------------------------ 113 kinase-sup:D ------------------------------------------------------------ 121 kinase-sup:E RF---------------------------------------------------------- 138 kinase-sup:F --ADEHNKM--------------------------------------------------- 6035 kinase-sup:G ---------AAEDYKM-------------------------------------------- 146 kinase-sup:H ----------------NTSAFEL------------------------------------- 116 kinase-sup:I -----------------------QMEL--------------------------------- 161 kinase-sup:J ---------------------------KCQKL---------------------------- 122 kinase-sup:K --------------------------------KTQHL----------------------- 119 kinase-sup:L -------------------------------------DASALTGI--------------- 99 kinase-sup:M ---------------------------------------------DKVPEPGV------- 117 kinase-sup:N -----------------------------------------------------PTL---- 128 kinase-sup:O --------------------------------------------------------NRYT 296 kinase-sup:A -SVKTVAMAAKQMLARVQSIHEK----------------------SLVYRDIK------- 133 kinase-sup:B -SLKTVLLLADQMISRIEYIHS-K---------------------NFIHRDV-K------ 133 kinase-sup:C -TERDASRLIFQVLDAVKYLHD--L--------------------GIVHRDL--K----- 143 kinase-sup:D -SEKETRKIMRALLEVICALHK---L-------------------NIVHRDL---K---- 151 kinase-sup:E -SEPHARFYAAQIVLTFEYLHS----L------------------DLIYRDL----K--- 168 kinase-sup:F -SEDEAVEYMRQVCKGLCHMHE-----N-----------------NYVHLDL-----K-- 6065 kinase-sup:G -SEAEVINYMRQACEGLKHMHE------H----------------SIVHLDI------K- 176 kinase-sup:H -NEREIVSYVHQVCEALQFLHS-------H---------------NIGHFDI-------R 146 kinase-sup:I -DHERMSYLLYQMLCGIKHLHS--------A--------------GIIHRDL-------- 190 kinase-sup:J -TDDHVQFLIYQILRGLKYIHS---------A-------------DIIHRDL-------- 151 kinase-sup:K -SNDHICYFLYQILRGLKYIHS----------A------------NVLHRDL-------- 148 kinase-sup:L -PLPLIKSYLFQLLQGLAFCHS-----------H-----------RVLHRDL-------- 128 kinase-sup:M -PTETIKDMMFQLLRGLDFLHS------------H----------RVVHRDL-------- 146 kinase-sup:N -TDYDIRYYIYELLKALDYCHS-------------Q---------GIMHRDV-------- 157 kinase-sup:O VTVEGMIKLALSTASGLAHLHM--------------EIVGTQGKPAIAHRDL-------- 334 kinase-sup:A -------PDNFLIGRPNSKNAN-------------------------------------- 148 kinase-sup:B -------PDNFLMG--------LGKKGN-------------------------------- 148 kinase-sup:C -------PENLLYY--------------SLDEDS-------------------------- 156 kinase-sup:D -------PENILLD--------------------DDM----------------------- 161 kinase-sup:E -------PENLLID-----------------------QQG-------------------- 178 kinase-sup:F -------PENIMFT--------------------------TKRSN--------------- 6077 kinase-sup:G -------PENIMCE-------------------------------TKKAS---------- 188 kinase-sup:H -------PENIIYQ------------------------------------TRRSS----- 158 kinase-sup:I K------PSNIVVK-----------------------------------------SDC-- 201 kinase-sup:J -K-----PSNLAVN--------------------------------------------ED 161 kinase-sup:K --K----PSNLLLN---------------------------------------------- 156 kinase-sup:L ---K---PQNLLIN---------------------------------------------- 136 kinase-sup:M ----K--PQNILVT---------------------------------------------- 154 kinase-sup:N -----K-PHNVMID---------------------------------------------- 165 kinase-sup:O ------KSKNILVK---------------------------------------------- 342 kinase-sup:A -----------------MIYVVDFGMVKFYRDPVTKQHIPYREKKNLSGT---------- 181 kinase-sup:B -----------------LVYIIDF--------------------------GLAKKYRDAR 165 kinase-sup:C -----------------KIMISDF------------------------------------ 163 kinase-sup:D -----------------NIKLTDF------------------------------------ 168 kinase-sup:E -----------------YIQVTDF------------------------------------ 185 kinase-sup:F -----------------ELKLIDF------------------------------------ 6084 kinase-sup:G -----------------SVKIIDF------------------------------------ 195 kinase-sup:H -----------------TIKIIEF------------------------------------ 165 kinase-sup:I -----------------TLKILDF------------------------------------ 208 kinase-sup:J C----------------ELKILDF------------------------------------ 169 kinase-sup:K -TTC-------------DLKICDF------------------------------------ 166 kinase-sup:L ----TEG----------AIKLADF------------------------------------ 146 kinase-sup:M -------SSG-------QIKLADF------------------------------------ 164 kinase-sup:N ----------HELR---KLRLIDW------------------------------------ 176 kinase-sup:O --------------KNGTCCIADL------------------------------------ 352 kinase-sup:A ------------------------------------------------------------ 181 kinase-sup:B THQHIPYRENKNLTGT-------------------------------------------- 181 kinase-sup:C ------------------------------------------------------------ 163 kinase-sup:D ----------------GFSCQLDPGEKLREVCGT-------------------------- 186 kinase-sup:E ----------------------------------GFAKRVKGRTWTLCGT---------- 201 kinase-sup:F --------------------------------------------------GLTAHLDPKQ 6094 kinase-sup:G ------------------------------------------------------------ 195 kinase-sup:H ------------------------------------------------------------ 165 kinase-sup:I ------------------------------------------------------------ 208 kinase-sup:J ------------------------------------------------------------ 169 kinase-sup:K ------------------------------------------------------------ 166 kinase-sup:L ------------------------------------------------------------ 146 kinase-sup:M ------------------------------------------------------------ 164 kinase-sup:N ------------------------------------------------------------ 176 kinase-sup:O ------------------------------------------------------------ 352 kinase-sup:A ------------------------------------------------------------ 181 kinase-sup:B ------------------------------------------------------------ 181 kinase-sup:C ------------------------------------------------------------ 163 kinase-sup:D ------------------------------------------------------------ 186 kinase-sup:E ------------------------------------------------------------ 201 kinase-sup:F SVKVTTGT---------------------------------------------------- 6102 kinase-sup:G --------GLATKLNPDEIVKVTTAT---------------------------------- 213 kinase-sup:H --------------------------GQARQLKPGDNFRLLFTA---------------- 183 kinase-sup:I --------------------------------------------GLASFMMTPYVVT--- 226 kinase-sup:J ---------------------------------------------------------GLA 172 kinase-sup:K ------------------------------------------------------------ 166 kinase-sup:L ------------------------------------------------------------ 146 kinase-sup:M ------------------------------------------------------------ 164 kinase-sup:N ------------------------------------------------------------ 176 kinase-sup:O ------------------------------------------------------------ 352 kinase-sup:A ------------------------------------------------------------ 181 kinase-sup:B ------------------------------------------------------------ 181 kinase-sup:C ------------------------------------------------------------ 163 kinase-sup:D ------------------------------------------------------------ 186 kinase-sup:E ------------------------------------------------------------ 201 kinase-sup:F ------------------------------------------------------------ 6102 kinase-sup:G ------------------------------------------------------------ 213 kinase-sup:H ------------------------------------------------------------ 183 kinase-sup:I ------------------------------------------------------------ 226 kinase-sup:J RHTDDEMTGYVAT----------------------------------------------- 185 kinase-sup:K -------------GLARVADPDHDHTGFLTEYVAT------------------------- 188 kinase-sup:L -----------------------------------GLARAFGVPVRTYTHEVVT------ 165 kinase-sup:M ------------------------------------------------------GLARIY 170 kinase-sup:N ------------------------------------------------------------ 176 kinase-sup:O ------------------------------------------------------------ 352 kinase-sup:A -----------------------------------------------------ARYMSIN 188 kinase-sup:B -----------------------------------------------------ARYASIN 188 kinase-sup:C -----------------------------------------------------PGYVAPE 188 kinase-sup:D -----------------------------------------------------PSYLAPE 193 kinase-sup:E -----------------------------------------------------PEYLAPE 208 kinase-sup:F -----------------------------------------------------AEFAAPE 6109 kinase-sup:G -----------------------------------------------------AEFAAPE 220 kinase-sup:H -----------------------------------------------------PEYYAPE 190 kinase-sup:I -----------------------------------------------------RYYRAPE 233 kinase-sup:J -----------------------------------------------------RWYRAPE 192 kinase-sup:K -----------------------------------------------------RWYRAPE 195 kinase-sup:L -----------------------------------------------------LWYRAPE 172 kinase-sup:M SFQMALTSVVVT-----------------------------------------LWYRAPE 189 kinase-sup:N ------------GLAEFYHPGKEYNVRVAS-----------------------RYFKGPE 201 kinase-sup:O ------------------------------GLAVRHDSATDTIDIAPNHRVGTKRYMAPE 382 kinase-sup:A THLGREQ----------------------------------------------------- 195 kinase-sup:B THLG---IEQ-------------------------------------------------- 195 kinase-sup:C VLAQ------KPY----------------------------------------------- 195 kinase-sup:D IIEC---------SMNDNHPGY-------------------------------------- 206 kinase-sup:E IILS------------------KGY----------------------------------- 215 kinase-sup:F VAEG---------------------KPV-------------------------------- 6116 kinase-sup:G IVDR------------------------EPV----------------------------- 227 kinase-sup:H VHQH---------------------------DVV-------------------------- 197 kinase-sup:I VILG------------------------------MGY----------------------- 240 kinase-sup:J IMLN---------------------------------WMHY------------------- 200 kinase-sup:K IMLN-------------------------------------SKGY--------------- 203 kinase-sup:L ILLG-----------------------------------------CKYY----------- 180 kinase-sup:M VLLQ---------------------------------------------SSY-------- 196 kinase-sup:N LLVD------------------------------------------------LQDY---- 209 kinase-sup:O VLDD----------------------------------------------------SINM 390 kinase-sup:A -----SRRDDLEALGHVFMYFLRGS----------------------------------- 215 kinase-sup:B -----SRRDDLESLGYVLMYFNL--GS--------------------------------- 215 kinase-sup:C -----SKAVDCWSIGVIAYILLC----GY------------------------------- 215 kinase-sup:D -----GKEVDMWSTGVIMYTLLA------GS----------------------------- 226 kinase-sup:E -----NKAVDWWALGVLIYEMAA--------GY--------------------------- 235 kinase-sup:F -----GYYTDMWSVGVLSYILLS----------GL------------------------- 6136 kinase-sup:G -----GFYTDMWAIGVLGYVLLS------------GL----------------------- 247 kinase-sup:H -----STATDMWSLGTLVYVLLS--------------GI--------------------- 217 kinase-sup:I -----KENVDIWSVGCIMGEMVR----------------HK------------------- 260 kinase-sup:J -----NQTVDIWSVGCIMAELLT------------------GR----------------- 220 kinase-sup:K -----TKSIDIWSVGCILAEMLS--------------------NR--------------- 223 kinase-sup:L -----STAVDIWSLGCIFAEMVT----------------------RR------------- 200 kinase-sup:M -----ATPVDLWSVGCIFAEMFR------------------------RK----------- 216 kinase-sup:N -----DYSLDMWSLGCMFAGMIF--------------------------RKE-------- 230 kinase-sup:O KHFESFKRADIYAMGLVFWEIAR-----------------------------RCSIGGIH 421 kinase-sup:A --------LPWQGLKAATNKQ---------------KYERIGEKKQSTPLRELCAGFP-- 250 kinase-sup:B --------LPWQG--------L--------------KYERISEKKM------------ST 240 kinase-sup:C --------PPFYD---------E-------------NDAKLFEQIL-------------- 231 kinase-sup:D --------PPFWH----------R------------KQMLMLRMIM-------------- 242 kinase-sup:E --------PPFFA-----------D-----------QPIQIYEKIV-------------- 251 kinase-sup:F --------SPFGG------------E----------NDDETLRNVK-------------- 6152 kinase-sup:G --------SPFAG-------------E---------DDLETLQNVK-------------- 263 kinase-sup:H --------NPFLA--------------E--------TNQQIIENIM-------------- 233 kinase-sup:I --------ILFPG---------------R-------DYIDQWNKVI-------------- 276 kinase-sup:J --------TLFPG----------------T------DHIDQLKLIL-------------- 236 kinase-sup:K --------PIFPG-----------------K-----HYLDQLNHIL-------------- 239 kinase-sup:L --------ALFPG------------------D----SEIDQLFRIF-------------- 216 kinase-sup:M --------PLFRG-------------------S---SDVDQLGKIL-------------- 232 kinase-sup:N --------PFFYG--------------------H--DNHDQLVKIA-------------- 246 kinase-sup:O EDYQLPYYDLVPS---------------------DPSVEEMRKVVC-------------- 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B PIEVLCKGYP-------------------------------------------------- 250 kinase-sup:C ----------KAEYEFDSPYWDDIS----------------------------------- 246 kinase-sup:D -------------------------SGNYQFGSPEWDDYS-------------------- 257 kinase-sup:E ----------------------------------------SGKVRFPSHFS--------- 262 kinase-sup:F ---------------------------------------------------SCDWNMDDS 6161 kinase-sup:G ------------------------------------------------------------ 263 kinase-sup:H ------------------------------------------------------------ 233 kinase-sup:I ------------------------------------------------------------ 276 kinase-sup:J ------------------------------------------------------------ 236 kinase-sup:K ------------------------------------------------------------ 239 kinase-sup:L ------------------------------------------------------------ 216 kinase-sup:M ------------------------------------------------------------ 232 kinase-sup:N ------------------------------------------------------------ 246 kinase-sup:O ------------------------------------------------------------ 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B ------------------------------------------------------------ 250 kinase-sup:C ------------------------------------------------------------ 246 kinase-sup:D ------------------------------------------------------------ 257 kinase-sup:E ------------------------------------------------------------ 262 kinase-sup:F AFSGIS------------------------------------------------------ 6167 kinase-sup:G ------RCDWEFDEDAFSSVS--------------------------------------- 278 kinase-sup:H ---------------------NAEYTFDEEAFKEIS------------------------ 248 kinase-sup:I ------------------------------------EQLGTPCPEFMKKLQPTVRNYVEN 300 kinase-sup:J ------------------------------------------------------------ 236 kinase-sup:K ------------------------------------------------------------ 239 kinase-sup:L ------------------------------------------------------------ 216 kinase-sup:M ------------------------------------------------------------ 232 kinase-sup:N ------------------------------------------------------------ 246 kinase-sup:O ------------------------------------------------------------ 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B ------------------------------------------------------------ 250 kinase-sup:C ------------------------------------------------------------ 246 kinase-sup:D ------------------------------------------------------------ 257 kinase-sup:E ------------------------------------------------------------ 262 kinase-sup:F ------------------------------------------------------------ 6167 kinase-sup:G ------------------------------------------------------------ 278 kinase-sup:H ------------------------------------------------------------ 248 kinase-sup:I RPKYAGLTFPKLFPDSLFPADSEHNKLKA------------------------------- 329 kinase-sup:J -----------------------------RLVGTPGAELLKKISSESARNYIQSLAQMPK 267 kinase-sup:K ------------------------------------------------------------ 239 kinase-sup:L ------------------------------------------------------------ 216 kinase-sup:M ------------------------------------------------------------ 232 kinase-sup:N ------------------------------------------------------------ 246 kinase-sup:O ------------------------------------------------------------ 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B ------------------------------------------------------------ 250 kinase-sup:C ------------------------------------------------------------ 246 kinase-sup:D ------------------------------------------------------------ 257 kinase-sup:E ------------------------------------------------------------ 262 kinase-sup:F ------------------------------------------------------------ 6167 kinase-sup:G ------------------------------------------------------------ 278 kinase-sup:H ------------------------------------------------------------ 248 kinase-sup:I ------------------------------------------------------------ 329 kinase-sup:J MNFANVFIGAN------------------------------------------------- 278 kinase-sup:K -----------GILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNAD------- 281 kinase-sup:L -----------------------------------------------------RTLGTPD 223 kinase-sup:M ------------------------------------------------------------ 232 kinase-sup:N ------------------------------------------------------------ 246 kinase-sup:O ------------------------------------------------------------ 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B ------------------------------------------------------------ 250 kinase-sup:C ------------------------------------------------------------ 246 kinase-sup:D ------------------------------------------------------------ 257 kinase-sup:E ------------------------------------------------------------ 262 kinase-sup:F ------------------------------------------------------------ 6167 kinase-sup:G ------------------------------------------------------------ 278 kinase-sup:H ------------------------------------------------------------ 248 kinase-sup:I ------------------------------------------------------------ 329 kinase-sup:J ------------------------------------------------------------ 278 kinase-sup:K ------------------------------------------------------------ 281 kinase-sup:L EVVWPGVTSMPDYKPSFPKWARQDFSKVVPPLD--------------------------- 256 kinase-sup:M ---------------------------------DVIGLPGEEDWPRDVALPRQAFHSKSA 259 kinase-sup:N ------------------------------------------------------------ 246 kinase-sup:O ------------------------------------------------------------ 446 kinase-sup:A ------------------------------------------------------------ 250 kinase-sup:B ------------------------------------------------------------ 250 kinase-sup:C ------------------------------------------------------------ 246 kinase-sup:D ------------------------------------------------------------ 257 kinase-sup:E ------------------------------------------------------------ 262 kinase-sup:F ------------------------------------------------------------ 6167 kinase-sup:G ------------------------------------------------------------ 278 kinase-sup:H ------------------------------------------------------------ 248 kinase-sup:I ------------------------------------------------------------ 329 kinase-sup:J ------------------------------------------------------------ 278 kinase-sup:K ------------------------------------------------------------ 281 kinase-sup:L ------------------------------------------------------------ 256 kinase-sup:M QPIEKFVTDID------------------------------------------------- 270 kinase-sup:N -----------KVLGTDGLNVYLNKYRIELDPQLEALVGRHSRKPWLKFMNADNQHLVS- 294 kinase-sup:O -----------------------------------------------------------E 447 kinase-sup:A -----------------EEFYKYMHYARNLAFDATPD----------------------- 270 kinase-sup:B -----------------SEFATYLNFCRS--------LRFDDKPD--------------- 270 kinase-sup:C -----------------DSAKDFIRHLME----------------KDPEKRFT------- 266 kinase-sup:D -----------------DTVKDLVSRFLV------------------------VQPQKRY 276 kinase-sup:E -----------------SDLKDLLRNLLQ------------------------------- 274 kinase-sup:F -----------------EDGKDFIRKLLL------------------------------- 6179 kinase-sup:G -----------------PEAKDFIKNLLQ------------------------------- 290 kinase-sup:H -----------------IEAMDFVDRLLV------------------------------- 260 kinase-sup:I -----------------SQARDLLSKMLV------------------------------- 341 kinase-sup:J -----------------PLAVDLLEKMLV------------------------------- 290 kinase-sup:K -----------------SKALDLLDKMLT------------------------------- 293 kinase-sup:L -----------------EDGRSLLSQMLH------------------------------- 268 kinase-sup:M -----------------ELGKDLLLKCLT------------------------------- 282 kinase-sup:N -----------------PEAIDFLDKLLR------------------------------- 306 kinase-sup:O QKLRPNIPNRWQSCEALRVMAKIMRECWY------------------------------- 476 kinase-sup:A ------------------------------------------------------------ 270 kinase-sup:B ------------------------------------------------------------ 270 kinase-sup:C ------------------------------------------------------------ 266 kinase-sup:D T----------------------------------------------------------- 277 kinase-sup:E -VDLTKRFGNLKDG---------------------------------------------- 287 kinase-sup:F --------------ADPNTRMT-------------------------------------- 6187 kinase-sup:G ----------------------KEPRKRLT------------------------------ 298 kinase-sup:H ------------------------------KERKSRMT---------------------- 268 kinase-sup:I --------------------------------------IDPAKRIS-------------- 349 kinase-sup:J ----------------------------------------------LDSDKRIT------ 298 kinase-sup:K ------------------------------------------------------FNPHKR 299 kinase-sup:L ------------------------------------------------------------ 268 kinase-sup:M ------------------------------------------------------------ 282 kinase-sup:N ------------------------------------------------------------ 306 kinase-sup:O ------------------------------------------------------------ 476 kinase-sup:A ----------------------------------YDYLQGLFSKVLERLNTTEDENFDWN 296 kinase-sup:B ----------------------------------YSYLR--------------------- 275 kinase-sup:C ----------------------------------CEQAL--------------------- 271 kinase-sup:D ----------------------------------AEEAL--------------------- 282 kinase-sup:E ----------------------------------VNDIK--------------------- 292 kinase-sup:F ----------------------------------IHQAL--------------------- 6192 kinase-sup:G ----------------------------------VHDAL--------------------- 303 kinase-sup:H ----------------------------------ASEAL--------------------- 273 kinase-sup:I ----------------------------------VDDAL--------------------- 354 kinase-sup:J ----------------------------------AAQAL--------------------- 303 kinase-sup:K IE--------------------------------VEQAL--------------------- 306 kinase-sup:L --YDPNKRIS------------------------AKAAL--------------------- 281 kinase-sup:M ----------FNPAKRIS----------------AYSAL--------------------- 295 kinase-sup:N ------------------YDHQERLT--------ALEAM--------------------- 319 kinase-sup:O --------------------------ANGAARLTALRIK--------------------- 489 kinase-sup:A LL---------------------------------------------------------- 298 kinase-sup:B --QLFRNLFHRQGFSYDYVFDWNMLKFGASR----------------------------- 304 kinase-sup:C -------------------------------QHPWIAGDTALDKNIHQSVSEQIKKNFAK 300 kinase-sup:D ------------------------------------------------------------ 282 kinase-sup:E ------------------------------------------------------------ 292 kinase-sup:F ------------------------------------------------------------ 6192 kinase-sup:G ------------------------------------------------------------ 303 kinase-sup:H ------------------------------------------------------------ 273 kinase-sup:I ------------------------------------------------------------ 354 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C SKWKQAFNATAVVRHM-------------------------------------------- 316 kinase-sup:D ----------------AHPFFQQYV----------------------------------- 291 kinase-sup:E -------------------------NHKWFATTDWIAIYQRKVEAPFIPKFKGPGDTSNF 327 kinase-sup:F ------------------------------------------------------------ 6192 kinase-sup:G ------------------------------------------------------------ 303 kinase-sup:H ------------------------------------------------------------ 273 kinase-sup:I ------------------------------------------------------------ 354 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E DDYEEEEIRVSINEKCGKEFSEF------------------------------------- 350 kinase-sup:F -----------------------EHPWLTPGNAPGRDSQIPSSRYTKIRDSIKTKYDAWP 6229 kinase-sup:G ------------------------------------------------------------ 303 kinase-sup:H ------------------------------------------------------------ 273 kinase-sup:I ------------------------------------------------------------ 354 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F EPLPPLGRISNYSSLRKHRPQEYSIRDAFWDRSEA------------------------- 6264 kinase-sup:G -----------------------------------EHPWLKGDHSNLTSRIPSSRYNKIR 328 kinase-sup:H ------------------------------------------------------------ 273 kinase-sup:I ------------------------------------------------------------ 354 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F ------------------------------------------------------------ 6264 kinase-sup:G QKIKEKYADWPAPQPAIGRIANFSSLRKHRPQEYQIYDSYFDRKEAV------------- 375 kinase-sup:H -----------------------------------------------QHPWLKQKIERVS 286 kinase-sup:I ------------------------------------------------------------ 354 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F ------------------------------------------------------------ 6264 kinase-sup:G ------------------------------------------------------------ 375 kinase-sup:H TKVIRTLKHRRYYHTLIKKDLNMVVSAARISCGGAIRSQKGVSVAKVKVASI-------- 338 kinase-sup:I ----------------------------------------------------QHPYINVW 362 kinase-sup:J ------------------------------------------------------------ 303 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F ------------------------------------------------------------ 6264 kinase-sup:G ------------------------------------------------------------ 375 kinase-sup:H ------------------------------------------------------------ 338 kinase-sup:I YDPAEVEAPPPQLDEREHTIEEWKELIYKEVMN--------------------------- 400 kinase-sup:J ---------------------------------AHAYFAQYHDPDDEPVADPYDQSFESR 330 kinase-sup:K ------------------------------------------------------------ 306 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F ------------------------------------------------------------ 6264 kinase-sup:G ------------------------------------------------------------ 375 kinase-sup:H ------------------------------------------------------------ 338 kinase-sup:I ------------------------------------------------------------ 400 kinase-sup:J DLLIDEWKSLTYDEVISFVPPPLD------------------------------------ 354 kinase-sup:K ------------------------AHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLK 342 kinase-sup:L ------------------------------------------------------------ 281 kinase-sup:M ------------------------------------------------------------ 295 kinase-sup:N ------------------------------------------------------------ 319 kinase-sup:O ------------------------------------------------------------ 489 kinase-sup:A ------------------------------------------------------------ 298 kinase-sup:B ------------------------------------------------------------ 304 kinase-sup:C ------------------------------------------------------------ 316 kinase-sup:D ------------------------------------------------------------ 291 kinase-sup:E ------------------------------------------------------------ 350 kinase-sup:F ------------------------------------------------------------ 6264 kinase-sup:G ------------------------------------------------------------ 375 kinase-sup:H ------------------------------------------------------------ 338 kinase-sup:I ------------------------------------------------------------ 400 kinase-sup:J ------------------------------------------------------------ 354 kinase-sup:K ELIFEETARFQPG----------------------------------------------- 355 kinase-sup:L -------------AHPFFQDVTKPVPHLRL------------------------------ 298 kinase-sup:M ------------------------------SHPYFQDLERCKEN---------------- 309 kinase-sup:N --------------------------------------------THPYFQQVRAAENS-- 333 kinase-sup:O ----------------------------------------------------------KT 491 kinase-sup:A --------- 298 kinase-sup:B --------- 304 kinase-sup:C --------- 316 kinase-sup:D --------- 291 kinase-sup:E --------- 350 kinase-sup:F --------- 6264 kinase-sup:G --------- 375 kinase-sup:H --------- 338 kinase-sup:I --------- 400 kinase-sup:J --------- 354 kinase-sup:K --------- 355 kinase-sup:L --------- 298 kinase-sup:M --------- 309 kinase-sup:N --------- 333 kinase-sup:O LSQLSQQEG 500