(igvar-l-sup:D, (((igvar-l-sup:P, (igvar-l-sup:Y, igvar-l-sup:Q)), (igvar-l-sup:S, ((igvar-l-sup:G, (igvar-l-sup:I, igvar-l-sup:H)), (igvar-l-sup:L, ((igvar-l-sup:O, (igvar-l-sup:N, igvar-l-sup:M)), ((igvar-l-sup:T, ((igvar-l-sup:X, (igvar-l-sup:U, (igvar-l-sup:W, igvar-l-sup:V))), (igvar-l-sup:K, igvar-l-sup:J))), (igvar-l-sup:Z, igvar-l-sup:R))))))), ((igvar-l-sup:B, (igvar-l-sup:C, igvar-l-sup:A)), (igvar-l-sup:F, igvar-l-sup:E)))) Core Residues: 94 Core RMSD: 1.574 Raw Score: 144.801 Reference structure: igvar-l-sup:D igvar-l-sup:A QS------VLTQP----------------------------------------------- 7 igvar-l-sup:B --S-----VLTQP----------------------------------------------- 7 igvar-l-sup:C ---ES---VLTQP----------------------------------------------- 7 igvar-l-sup:D -----AS-VLTQP----------------------------------------------- 7 igvar-l-sup:E -------SALTQP----------------------------------------------- 7 igvar-l-sup:F --------ELTQP----------------------------------------------- 7 igvar-l-sup:G --------DIVLTQSP-------------------------------------------- 8 igvar-l-sup:H --------QIVLT---QSP----------------------------------------- 8 igvar-l-sup:I --------EIVLT------QSP-------------------------------------- 8 igvar-l-sup:J --------DIQMT---------QSP----------------------------------- 8 igvar-l-sup:K --------DIQMT------------QSP-------------------------------- 8 igvar-l-sup:L --------DIQMT---------------QSP----------------------------- 8 igvar-l-sup:M --------DIQMT------------------QSP-------------------------- 8 igvar-l-sup:N --------DIQMT---------------------QSP----------------------- 8 igvar-l-sup:O --------DIELT------------------------QTP-------------------- 8 igvar-l-sup:P --------DIQMT---------------------------QIP----------------- 8 igvar-l-sup:Q --------DIQMT------------------------------QTT-------------- 8 igvar-l-sup:R --------DIELT---------------------------------QSP----------- 8 igvar-l-sup:S --------DVVMT------------------------------------QTP-------- 8 igvar-l-sup:T --------DVLMT---------------------------------------QTP----- 8 igvar-l-sup:U --------DIVMT------------------------------------------QSP-- 8 igvar-l-sup:V --------DIVMT---------------------------------------------QS 7 igvar-l-sup:W --------DIVMT----------------------------------------------- 5 igvar-l-sup:X --------DIVMT----------------------------------------------- 5 igvar-l-sup:Y --------DIVMT----------------------------------------------- 5 igvar-l-sup:Z --------DIVLT----------------------------------------------- 5 igvar-l-sup:A -------------PSASGTPGQRVTISCSGTSS----------NIGSS------------ 30 igvar-l-sup:B -------------PSASGTPGQRVTISCSGS--SS--------NIGE-N----------- 32 igvar-l-sup:C -------------PSASGTPGQRVTISCTGS----AT------DIGS--N---------- 32 igvar-l-sup:D -------------PSVSGAPGQRVTISCTGS------SSN---IGAG---H--------- 33 igvar-l-sup:E -------------PSASGSLGQSVTISCTGT---------SSDVGGY----N-------- 33 igvar-l-sup:F -------------PSVSVSPGQTARITCSAN------------ALPN-----Q------- 30 igvar-l-sup:G -------------AIMSASPGEKVTMTCSAS------------SSVN------------- 31 igvar-l-sup:H -------------AIMSASPGEKVTMTCSAS------------SSVY------------- 30 igvar-l-sup:I -------------AITAASLGQKVTITCSAS------------SSVS------------- 30 igvar-l-sup:J -------------SSLSASVGDRVTITCQAS------------QDII------K------ 31 igvar-l-sup:K -------------SSLSASVGDRVTITCQAS------------QDIS-------N----- 31 igvar-l-sup:L -------------STLSASVGDRVTITCRAS------------QSIS--------R---- 31 igvar-l-sup:M -------------ASLSASVGETVTITCRAS------------GNIH---------N--- 31 igvar-l-sup:N -------------SSLSASVGDRVTITCRAS------------GNIH----------N-- 31 igvar-l-sup:O -------------VSLSASVGETVTITCRAS------------ENIY-----------S- 31 igvar-l-sup:P -------------SSLSASLGDRVSISCRAS------------QDIN------------N 31 igvar-l-sup:Q -------------SSLSASLGDRVTISCRAS------------QDIY------------- 36 igvar-l-sup:R -------------SYLVASPGETITINCRAS------------KSIS------------- 30 igvar-l-sup:S -------------LSLPVSLGDQASISCRSS------------QSLV------------- 30 igvar-l-sup:T -------------LSLPVSLGDQASISCRSN------------QTIL------------- 27C igvar-l-sup:U -------------SSLSVSAGERVTMSCKSS------------QSLL------------- 30 igvar-l-sup:V P------------SSLTVTAGEKVTMSCTSS------------QSLF------------- 27C igvar-l-sup:W -QSP---------SSLTVTTGEKVTMTCKSS------------QSLL------------- 30 igvar-l-sup:X ----QSP------DSLAVSLGERATINCKSS------------QSVL------------- 27C igvar-l-sup:Y -------QSP---KFMSTSVGDRVTITCKAS------------QDVS------------- 30 igvar-l-sup:Z ----------QSPATLSVTPGNSVSLSCRAS------------QSIG------------- 30 igvar-l-sup:A --------------------------------------------TVNWYQQLPGMAPKLL 46 igvar-l-sup:B --------------------------------------------SVTWYQHLSGTAPKLL 48 igvar-l-sup:C --------------------------------------------SVIWYQQVPGKAPKLL 48 igvar-l-sup:D --------------------------------------------NVKWYQQLPGTAPKLL 49 igvar-l-sup:E --------------------------------------------YVSWYQQHAGKAPKVI 49 igvar-l-sup:F --------------------------------------------YAYWYQQKPGRAPVMV 46 igvar-l-sup:G --------------------------------------------YMYWYQQKSGTSPKRW 47 igvar-l-sup:H --------------------------------------------YMYWYQQKPGSSPRLL 46 igvar-l-sup:I --------------------------------------------SLHWYQQKSGTSPKPW 46 igvar-l-sup:J --------------------------------------------YLNWYQQTPGKAPKLL 47 igvar-l-sup:K --------------------------------------------YLAWYQQKPGKAPELR 47 igvar-l-sup:L --------------------------------------------WLAWYQQKPGKVPKLL 47 igvar-l-sup:M --------------------------------------------YLAWYQQKQGKSPQLL 47 igvar-l-sup:N --------------------------------------------YLAWYQQKPGKAPKLL 47 igvar-l-sup:O --------------------------------------------YLAWYQQKQGKSPQFL 47 igvar-l-sup:P --------------------------------------------FLNWYQQKPDGTIKLL 47 igvar-l-sup:Q N-------------------------------------------YLNWYQQKPDGTVKLL 53 igvar-l-sup:R -K------------------------------------------SLAWYQEKPGKTNNLL 47 igvar-l-sup:S --HSQGNT------------------------------------YLRWYLQKPGQSPKVL 52 igvar-l-sup:T --------LSDGDT------------------------------YLEWYLQKPGQSPKLL 47 igvar-l-sup:U --------------NSGNQKN-----------------------FLAWYQQKPGQPPKLL 53 igvar-l-sup:V ---------------------NSGKQKN----------------YLTWYQQKPGQPPKVL 47 igvar-l-sup:W ----------------------------NSRTQKN---------YLTWYQQKPGQSPKLL 53 igvar-l-sup:X -----------------------------------YSSNSKN--YLAWYQQKPGQPPKLL 47 igvar-l-sup:Y ------------------------------------------T-AVVWYQQKPGQSPKLL 47 igvar-l-sup:Z -------------------------------------------NNLHWYQQKSHESPRLL 47 igvar-l-sup:A IYRD-------------------------------------------------------- 50 igvar-l-sup:B I---YED----------------------------------------------------- 52 igvar-l-sup:C I------YYN-------------------------------------------------- 52 igvar-l-sup:D I----------------------------------------------------------- 50 igvar-l-sup:E I---------YEV----------------------------------------------- 53 igvar-l-sup:F I------------YKD-------------------------------------------- 50 igvar-l-sup:G I---------------YDT----------------------------------------- 51 igvar-l-sup:H I------------------YDT-------------------------------------- 50 igvar-l-sup:I I---------------------YEI----------------------------------- 50 igvar-l-sup:J I------------------------YEA-------------------------------- 51 igvar-l-sup:K I---------------------------YDA----------------------------- 51 igvar-l-sup:L I------------------------------YKA-------------------------- 51 igvar-l-sup:M V---------------------------------YYT----------------------- 51 igvar-l-sup:N I------------------------------------YYT-------------------- 51 igvar-l-sup:O V---------------------------------------YNA----------------- 51 igvar-l-sup:P I------------------------------------------YFTS------------- 52 igvar-l-sup:Q I----------------------------------------------YYT---------- 57 igvar-l-sup:R I-------------------------------------------------YSG------- 51 igvar-l-sup:S I----------------------------------------------------YKV---- 56 igvar-l-sup:T I-------------------------------------------------------YKV- 51 igvar-l-sup:U I----------------------------------------------------------Y 55 igvar-l-sup:V I----------------------------------------------------------- 48 igvar-l-sup:W I----------------------------------------------------------- 54 igvar-l-sup:X I----------------------------------------------------------- 48 igvar-l-sup:Y I----------------------------------------------------------- 48 igvar-l-sup:Z I----------------------------------------------------------- 48 igvar-l-sup:A -----------------AMRPSGVP----------------------------------- 58 igvar-l-sup:B -----------------NSRA----SGVS------------------------------- 60 igvar-l-sup:C -----------------DLLP--------SGVS--------------------------- 60 igvar-l-sup:D -----------------FHNN--------------------------------------- 54 igvar-l-sup:E -----------------NKRP------------SGVP----------------------- 61 igvar-l-sup:F -----------------TQRP----------------SGIP------------------- 58 igvar-l-sup:G -----------------SKLA--------------------SGVP--------------- 59 igvar-l-sup:H -----------------SNLA------------------------SGVP----------- 58 igvar-l-sup:I -----------------SKLA----------------------------SGVP------- 58 igvar-l-sup:J -----------------SNLQ--------------------------------AGVP--- 59 igvar-l-sup:K -----------------SNLE------------------------------------TGV 58 igvar-l-sup:L -----------------SSLE--------------------------------------- 55 igvar-l-sup:M -----------------TTLA--------------------------------------- 55 igvar-l-sup:N -----------------TTLA--------------------------------------- 55 igvar-l-sup:O -----------------KTLG--------------------------------------- 55 igvar-l-sup:P -----------------RSQS--------------------------------------- 56 igvar-l-sup:Q -----------------SRLH--------------------------------------- 61 igvar-l-sup:R -----------------STLQ--------------------------------------- 55 igvar-l-sup:S -----------------SNRF--------------------------------------- 60 igvar-l-sup:T -----------------SNRF--------------------------------------- 55 igvar-l-sup:U GA---------------STRE--------------------------------------- 61 igvar-l-sup:V --YWA------------STRE--------------------------------------- 55 igvar-l-sup:W -----YWA---------STRE--------------------------------------- 61 igvar-l-sup:X --------YWA------STRE--------------------------------------- 55 igvar-l-sup:Y -----------YWA---STRH--------------------------------------- 55 igvar-l-sup:Z --------------KYASQSI--------------------------------------- 55 igvar-l-sup:A ------------------------------------------------------------ 58 igvar-l-sup:B ------------------------------------------------------------ 60 igvar-l-sup:C ------------------------------------------------------------ 60 igvar-l-sup:D ------------------------------------------------------------ 54 igvar-l-sup:E ------------------------------------------------------------ 61 igvar-l-sup:F ------------------------------------------------------------ 58 igvar-l-sup:G ------------------------------------------------------------ 59 igvar-l-sup:H ------------------------------------------------------------ 58 igvar-l-sup:I ------------------------------------------------------------ 58 igvar-l-sup:J ------------------------------------------------------------ 59 igvar-l-sup:K P----------------------------------------------------------- 59 igvar-l-sup:L -SGVP------------------------------------------------------- 59 igvar-l-sup:M -----DGVP--------------------------------------------------- 59 igvar-l-sup:N ---------DGVP----------------------------------------------- 59 igvar-l-sup:O -------------EGVP------------------------------------------- 59 igvar-l-sup:P -----------------GVP---------------------------------------- 59 igvar-l-sup:Q --------------------SGVP------------------------------------ 65 igvar-l-sup:R ------------------------SGIP-------------------------------- 59 igvar-l-sup:S ----------------------------SGVP---------------------------- 64 igvar-l-sup:T --------------------------------SGVP------------------------ 59 igvar-l-sup:U ------------------------------------SGVP-------------------- 65 igvar-l-sup:V ----------------------------------------SGVP---------------- 59 igvar-l-sup:W --------------------------------------------SGVP------------ 65 igvar-l-sup:X ------------------------------------------------SGVP-------- 59 igvar-l-sup:Y ----------------------------------------------------IGVP---- 59 igvar-l-sup:Z --------------------------------------------------------SGIP 59 igvar-l-sup:A DRFSGSKSGASASLAIGGLQSEDETDYYCAAWDVS------------------------- 93 igvar-l-sup:B DRFSASKSGTSASLAISGLQPEDETDYYCAA----WDDS--------------------- 95 igvar-l-sup:C DRFSASKSGTSASLAISGLESEDEADYYCAA--------WNDS----------------- 95 igvar-l-sup:D ARFSVSKSGTSATLAITGLQAEDEADYYCQS------------YD--------------- 87 igvar-l-sup:E DRFSGSKSGNTASLTVSGLQAEDEADYYCSS--------------YEG------------ 95 igvar-l-sup:F QRFSSSTSGTTVTLTISGVQAEDEADYYCQA-----------------WD---------- 91 igvar-l-sup:G VRFSGSGSGTSYSLTISSMETEDAATYYCQQ-------------------W--------- 91 igvar-l-sup:H VRFSGSGSGTSYSLTISRMEAEDAATYYCQQ--------------------WSS------ 92 igvar-l-sup:I ARFSGSGSGTSYSLTINTMEAEDAAIYYCQQ-----------------------WT---- 91 igvar-l-sup:J SRFSGSGSGTDYTFTISSLQPEDIATYYCQQ-------------------------YQ-- 92 igvar-l-sup:K SRFSGSGSGTDFTFTISSLQPEDIATYYCQQ---------------------------YQ 92 igvar-l-sup:L SRFSGSGSGTEFTLTISSLQPDDFATYYCQQ----------------------------- 90 igvar-l-sup:M SRFSGSGSGTQYSLKINSLQPEDFGSYYCQH----------------------------- 90 igvar-l-sup:N SRFSGSGSGTDYTFTISSLQPEDIATYYCQH----------------------------- 90 igvar-l-sup:O SRFSGSGSGTQFSLKINSLLPEDFGSYYCQH----------------------------- 90 igvar-l-sup:P SRFSGSGSGTDYSLTISNLEQEDIATYFCQQ----------------------------- 90 igvar-l-sup:Q SRFSGSGSGTDYSLTISNLNQEDMATYICQQ----------------------------- 96 igvar-l-sup:R SRFSGSGSGTDFTLTISSLEPEDFAMYICQQ----------------------------- 90 igvar-l-sup:S DRFSGSGSGTDFTLKISRVEAEDLGVYFCSQ----------------------------- 95 igvar-l-sup:T DRFSGSGSGTDFTLKISRVEAEDLGVYYCFQ----------------------------- 90 igvar-l-sup:U DRFTGSGSGTDFTLTISSVQAEDLAVYYCQN----------------------------- 96 igvar-l-sup:V DRFTGSGSGTDFTLTISSVQAEDLAVYYCQN----------------------------- 90 igvar-l-sup:W DRFTGSGSGTDFTLSISGVQAEDLAVYYCQN----------------------------- 96 igvar-l-sup:X DRFSGSGSGTDFTLTISSLQAEDVAVYYCQQ----------------------------- 90 igvar-l-sup:Y DRFAGSGSGTDYTLTISSVQAEDLALYYCQQ----------------------------- 90 igvar-l-sup:Z SRFSGSGSGTDFTLSINSVETEDFGMYFCQQ----------------------------- 90 igvar-l-sup:A -----------------------------LNAYVFGTGTKVTVLGQPKAN---------- 114 igvar-l-sup:B -----------------------------LDVAVFGTGTKVTVL------GQPKANP--- 117 igvar-l-sup:C -----------------------------LDEPGFGGGTKLTVL-------------GQP 113 igvar-l-sup:D -----------------------------RSLRVFGGGTKLTVL---------------- 102 igvar-l-sup:E -----------------------------SDNFVFGTGTKVTVL---------------- 110 igvar-l-sup:F -----------------------------NSASIFGGGTKLTVL---------------- 106 igvar-l-sup:G -----------------------------GRNPTFGGGTKLEIK---------------- 107 igvar-l-sup:H -----------------------------YPPITFGVGTKLELK---------------- 107 igvar-l-sup:I -----------------------------YPLITFGAGTKLELK---------------- 106 igvar-l-sup:J -----------------------------SLPYTFGQGTKLQIT---------------- 107 igvar-l-sup:K -----------------------------NLPLTFGPGTKVDIK---------------- 107 igvar-l-sup:L -----------------------------YNSYSFGPGTKVDIK---------------- 105 igvar-l-sup:M FW---------------------------STPRTFGGGTKLEIK---------------- 107 igvar-l-sup:N --FW-------------------------STPRTFGQGTKVEIK---------------- 107 igvar-l-sup:O ----HYG----------------------TPPLTFGGGTKLEIK---------------- 108 igvar-l-sup:P -------GN--------------------ALPRTFGGGTKLEIK---------------- 107 igvar-l-sup:Q ---------GN------------------TLPFTFGSGTKLEIK---------------- 113 igvar-l-sup:R -----------HN----------------EYPWTFGGGTKLEIK---------------- 107 igvar-l-sup:S -------------ST--------------HVPWTFGGGTKLEIK---------------- 112 igvar-l-sup:T ---------------GS------------HVPPTFGGGTKLEIK---------------- 107 igvar-l-sup:U -----------------DH----------SYPLTFGAGTKLEIK---------------- 113 igvar-l-sup:V -------------------DY--------SNPLTFGGGTKLELK---------------- 107 igvar-l-sup:W ---------------------NY------NYPLTFGAGTKLELK---------------- 113 igvar-l-sup:X -----------------------YY----STPYSFGQGTKLEIK---------------- 107 igvar-l-sup:Y -------------------------HY--SPPWTFGGGTKLEIK---------------- 107 igvar-l-sup:Z ---------------------------SNSWPYTFGGGTKLEIK---------------- 107 igvar-l-sup:A ------------------------------------------------------------ 114 igvar-l-sup:B ------------------------------------------------------------ 117 igvar-l-sup:C K----------------------------------------------------------- 114 igvar-l-sup:D -RQPKAA----------------------------------------------------- 108 igvar-l-sup:E -------GQPKAN----------------------------------------------- 116 igvar-l-sup:F -------------GQPKAA----------------------------------------- 112 igvar-l-sup:G -------------------RAD-------------------------------------- 110 igvar-l-sup:H ----------------------RADAA--------------------------------- 112 igvar-l-sup:I ---------------------------RADAA---------------------------- 111 igvar-l-sup:J ------------------------------------------------------------ 107 igvar-l-sup:K --------------------------------RTVAA----------------------- 112 igvar-l-sup:L -------------------------------------RTVAA------------------ 110 igvar-l-sup:M ------------------------------------------RADAA------------- 112 igvar-l-sup:N -----------------------------------------------R------------ 108 igvar-l-sup:O ------------------------------------------------------------ 108 igvar-l-sup:P ------------------------------------------------RADAA------- 112 igvar-l-sup:Q -----------------------------------------------------RADAA-- 118 igvar-l-sup:R ----------------------------------------------------------R- 108 igvar-l-sup:S -----------------------------------------------------------R 113 igvar-l-sup:T ------------------------------------------------------------ 107 igvar-l-sup:U ------------------------------------------------------------ 113 igvar-l-sup:V ------------------------------------------------------------ 107 igvar-l-sup:W ------------------------------------------------------------ 113 igvar-l-sup:X ------------------------------------------------------------ 107 igvar-l-sup:Y ------------------------------------------------------------ 107 igvar-l-sup:Z ------------------------------------------------------------ 107 igvar-l-sup:A ----------------------------------- 114 igvar-l-sup:B ----------------------------------- 117 igvar-l-sup:C ----------------------------------- 114 igvar-l-sup:D ----------------------------------- 108 igvar-l-sup:E ----------------------------------- 116 igvar-l-sup:F ----------------------------------- 112 igvar-l-sup:G ----------------------------------- 110 igvar-l-sup:H ----------------------------------- 112 igvar-l-sup:I ----------------------------------- 111 igvar-l-sup:J ----------------------------------- 107 igvar-l-sup:K ----------------------------------- 112 igvar-l-sup:L ----------------------------------- 110 igvar-l-sup:M ----------------------------------- 112 igvar-l-sup:N ----------------------------------- 108 igvar-l-sup:O ----------------------------------- 108 igvar-l-sup:P ----------------------------------- 112 igvar-l-sup:Q ----------------------------------- 118 igvar-l-sup:R ----------------------------------- 108 igvar-l-sup:S ADAA------------------------------- 117 igvar-l-sup:T ----RADAA-------------------------- 112 igvar-l-sup:U ---------RADAA--------------------- 118 igvar-l-sup:V --------------RADAA---------------- 112 igvar-l-sup:W -------------------RADAA----------- 118 igvar-l-sup:X ------------------------R---------- 108 igvar-l-sup:Y -------------------------RADAA----- 112 igvar-l-sup:Z ------------------------------RADAA 112