The following data was calculated using an automated search for amphipathic strands in a non-redundant sequence database. Conditional probabilities for alignment of buried residues. Value in row i, column j = 100 * P(seeing res. i, given that it is aligned with res. j) A C D E F G H I K L M N P Q R S T V W Y A 5.8 5.5 8.9 19.5 7.5 3.6 12.6 7.8 5.5 8.8 5.4 10.0 6.9 4.6 2.9 6.7 8.4 7.8 7.9 7.4 C 2.2 11.1 3.5 2.4 2.8 4.3 3.1 2.5 5.5 2.8 1.4 3.3 13.9 2.3 2.9 4.3 4.2 2.2 6.1 3.0 D 1.0 1.0 0.8 0.8 0.6 2.1 1.5 0.8 0.8 0.3 0.9 5.0 4.6 0.8 5.8 3.0 0.6 0.8 0.8 0.3 E 1.6 0.5 0.6 4.8 0.9 0.3 3.1 0.6 11.1 0.4 1.4 0.6 0.6 0.6 0.6 1.2 0.6 0.1 0.6 0.6 F 9.9 9.0 7.1 14.6 11.9 13.8 11.1 8.4 11.1 9.1 11.8 5.0 11.6 13.9 8.8 14.1 11.4 9.0 8.8 11.1 G 2.0 6.0 10.7 2.4 5.9 6.5 7.9 3.6 4.3 3.6 2.9 1.6 13.9 2.3 2.9 3.0 6.0 4.4 2.6 5.2 H 1.6 1.0 1.7 4.8 1.1 1.8 6.3 0.6 0.9 0.6 0.9 1.6 0.9 2.3 0.9 3.7 1.2 0.2 0.8 0.9 I 17.6 14.1 16.0 17.0 14.3 14.1 11.1 20.5 16.6 17.8 18.8 11.6 9.3 13.9 5.8 15.4 8.4 17.7 15.9 15.7 K 0.2 0.5 0.2 4.8 0.3 0.2 0.2 0.2 0.2 0.4 0.2 0.2 0.2 2.3 2.9 0.6 0.2 0.2 0.2 0.2 L 18.9 14.6 7.1 12.1 14.7 13.8 11.1 17.0 27.7 18.0 16.8 13.3 9.3 11.6 5.8 13.5 15.0 16.0 13.2 16.6 M 2.2 1.5 3.5 7.3 3.7 2.1 3.1 3.5 3.1 3.3 5.9 1.6 2.3 9.3 2.9 0.6 4.2 2.9 2.6 3.3 N 1.2 1.0 5.3 0.9 0.4 0.3 1.5 0.6 0.9 0.7 0.4 0.9 2.3 4.6 2.9 1.2 3.6 0.7 4.4 0.3 P 0.6 3.0 3.5 0.6 0.7 2.1 0.6 0.3 0.6 0.3 0.4 1.6 0.6 2.3 0.6 1.2 0.6 0.2 3.5 0.6 Q 0.4 0.5 0.6 0.6 0.9 0.3 1.5 0.5 5.5 0.4 1.9 3.3 2.3 0.6 2.9 1.8 0.6 0.6 1.7 0.3 R 0.2 0.5 3.5 0.5 0.4 0.3 0.5 0.1 5.5 0.1 0.4 1.6 0.5 2.3 0.5 0.6 2.4 0.6 1.7 1.5 S 2.2 3.5 8.9 4.8 3.6 1.8 9.5 2.3 5.5 2.1 0.4 3.3 4.6 6.9 2.9 8.6 0.6 1.6 4.4 2.1 T 2.9 3.5 1.7 2.4 2.9 3.6 3.1 1.2 2.5 2.4 3.4 10.0 2.3 2.3 11.7 0.6 2.4 3.0 1.7 3.3 V 22.2 15.1 21.4 4.8 19.3 22.1 6.3 22.2 16.6 21.1 19.8 16.6 6.9 20.9 26.4 13.5 25.3 25.4 12.3 19.7 W 1.8 3.5 1.7 1.7 1.5 1.0 1.5 1.6 1.7 1.4 1.4 8.3 9.3 4.6 5.8 3.0 1.2 1.0 3.5 2.7 Y 4.9 5.0 1.7 4.8 5.6 6.1 4.7 4.7 5.0 5.2 5.4 1.6 4.6 2.3 14.7 4.3 6.6 4.7 7.9 4.9 Conditional probabilities for alignment of exposed residues. Value in row i, column j = 100 * P(seeing res. i, given that it is aligned with res. j) A C D E F G H I K L M N P Q R S T V W Y A 5.4 7.6 4.0 2.9 5.0 4.0 4.7 5.0 2.8 5.5 4.4 3.6 3.1 2.0 4.1 3.4 2.7 5.4 2.1 5.9 C 2.3 10.2 0.4 0.2 2.5 0.5 0.9 0.8 0.9 1.2 0.8 1.0 1.5 0.3 1.6 1.4 1.2 1.0 2.1 1.8 D 3.8 1.2 2.4 2.1 2.5 4.0 5.2 3.5 6.7 3.2 3.5 3.6 1.5 4.8 6.4 5.3 3.7 2.1 4.3 2.7 E 5.4 1.2 4.0 5.1 7.6 4.0 5.6 5.7 15.8 6.4 10.6 9.3 7.9 7.3 13.0 5.1 8.0 6.0 7.6 4.6 F 4.6 7.6 2.4 3.8 6.7 7.6 7.1 2.4 2.6 4.0 7.0 2.5 3.1 2.7 1.1 5.3 3.6 2.9 4.3 3.7 G 2.7 1.2 2.8 1.4 5.5 3.5 4.2 3.0 0.7 4.0 6.1 4.1 1.5 1.7 2.9 2.9 1.8 2.0 3.2 3.7 H 3.8 2.5 4.5 2.5 6.3 5.2 2.8 2.8 3.0 3.0 4.4 2.0 4.7 2.7 2.2 3.4 3.3 3.4 2.1 4.9 I 8.9 5.1 6.5 5.5 4.6 8.1 6.1 13.1 6.9 9.4 9.7 5.1 6.3 6.6 6.8 7.0 5.4 7.6 7.6 5.9 K 5.8 6.4 14.7 17.9 5.9 2.3 7.5 8.1 8.6 7.7 10.6 8.8 3.1 9.4 5.9 5.3 7.2 6.5 9.8 11.8 L 10.0 7.6 6.1 6.4 8.0 11.1 6.6 9.6 6.7 10.3 5.3 3.1 14.2 6.2 5.2 6.5 4.8 10.9 7.6 6.5 M 1.9 1.2 1.6 2.5 3.3 4.0 2.3 2.4 2.2 1.2 3.5 1.5 1.5 1.3 2.0 1.4 1.0 1.4 1.0 0.6 N 2.7 2.5 2.8 3.8 2.1 4.6 1.8 2.1 3.2 1.2 2.6 3.1 3.1 4.5 4.5 3.1 3.7 1.8 4.3 4.0 P 0.7 1.2 0.4 1.0 0.8 0.5 1.4 0.8 0.3 1.9 0.8 1.0 1.0 0.6 1.1 0.4 0.7 1.2 2.1 2.4 Q 2.3 1.2 5.7 4.4 3.3 2.9 3.7 4.1 5.0 3.8 3.5 6.7 3.1 8.3 3.4 3.9 5.9 4.5 6.5 4.6 R 6.9 8.9 11.4 12.2 2.1 7.6 4.7 6.5 4.9 4.9 7.9 10.3 7.9 5.2 2.7 6.8 8.4 8.2 10.9 5.9 S 5.4 7.6 9.0 4.4 9.3 7.0 6.6 6.3 4.1 5.7 5.3 6.7 3.1 5.5 6.4 8.7 10.3 4.5 5.4 6.8 T 6.9 10.2 10.2 11.3 10.1 7.0 10.4 7.9 9.0 6.8 6.1 12.9 7.9 13.6 12.8 16.5 15.7 11.3 2.1 4.3 V 11.6 7.6 4.9 7.0 6.7 6.4 9.0 9.2 6.7 12.8 7.0 5.1 11.1 8.7 10.3 6.0 9.3 11.3 9.8 9.3 W 0.7 2.5 1.6 1.4 1.6 1.7 0.9 1.5 1.6 1.5 0.8 2.0 3.1 2.0 2.2 1.2 0.3 1.6 2.1 1.2 Y 7.3 7.6 3.6 3.2 5.0 7.0 7.5 4.1 7.1 4.5 1.7 6.7 12.6 5.2 4.3 5.3 2.1 5.4 4.3 8.6